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1. Frozanpor F, Albiin N, Linder S, Segersvärd R, Lundell L, Arnelo U: Impact of pancreatic gland volume on fistula formation after pancreatic tail resection. JOP; 2010;11(5):439-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CONTEXT: Resection of the body and tail of the pancreas (distal pancreatectomy) is associated with high postoperative morbidity, most of which is due to leakage from the pancreatic transection surface.
  • MAIN OUTCOME MEASURES: The impact of patient, tumor, surgery, and radiology-related factors on the risk of pancreatic fistula formation were assessed by univariate and multivariate analyses.
  • RESULTS: A distal pancreatectomy was performed in 51 patients (median age: 59 years; range: 26-76 years), 22 of whom had malignant and 29 benign or premalignant disease.
  • The volume of the remaining pancreas and the technique of closure of the transected pancreas were found to affect this risk, thus allowing future preventive measures to be explored and evaluated in clinical trials.
  • [MeSH-major] Pancreas / pathology. Pancreas / surgery. Pancreatectomy / adverse effects. Pancreatic Fistula / etiology

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  • (PMID = 20818111.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Italy
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2. Miyamoto H, Molena DA, Schoeniger LO, Haodong Xu: Solitary fibrous tumor of the pancreas: a case report. Int J Surg Pathol; 2007 Jul;15(3):311-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary fibrous tumor of the pancreas: a case report.
  • Solitary fibrous tumor (SFT) is an unusual mesenchymal neoplasm that most often arises in the pleura; however, it has recently been described in a number of extrapleural sites.
  • This report describes an extremely rare case of a benign SFT arising in the pancreas.
  • Subsequent ultrasonographic studies revealed a 1.5x1.5x1.4 cm hypoechoic mass within the pancreatic body, which was later confirmed on both helical computerized tomography and magnetic resonance imaging studies.
  • An endocrine tumor was clinically suspected.
  • Microscopically, the tumor was composed of bland uniform spindle cells arranged between collagen bundles.
  • [MeSH-minor] Adult. Antigens, CD34 / genetics. Antigens, CD34 / metabolism. Female. Gene Expression Regulation, Neoplastic. Humans. Magnetic Resonance Imaging. Pancreas / pathology. Pancreas / radiography. Pancreas / ultrasonography. Proto-Oncogene Proteins c-bcl-2 / genetics. Proto-Oncogene Proteins c-bcl-2 / metabolism. Tomography, X-Ray Computed

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  • (PMID = 17652547.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Proto-Oncogene Proteins c-bcl-2
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3. Woenckhaus M, Grepmeier U, Werner B, Schulz C, Rockmann F, Wild PJ, Röckelein G, Blaszyk H, Schuierer M, Hofstaedter F, Hartmann A, Dietmaier W: Microsatellite analysis of pleural supernatants could increase sensitivity of pleural fluid cytology. J Mol Diagn; 2005 Oct;7(4):517-24
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  • A common diagnostic problem lies in distinguishing malignant from benign pleural effusions using routine cytological evaluation.
  • We studied pleural fluid samples obtained from 14 patients with histologically confirmed malignancy and from 6 patients with benign pleural effusions using 12 microsatellite markers from 8 different chromosomal regions.
  • Microsatellite analyses of pleural fluid supernatants showed genetic alterations in tumor patients only.
  • [MeSH-major] Body Fluids / metabolism. Diagnostic Tests, Routine / methods. Microsatellite Repeats / genetics. Pleura / metabolism. Pleura / pathology

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  • (PMID = 16237222.001).
  • [ISSN] 1525-1578
  • [Journal-full-title] The Journal of molecular diagnostics : JMD
  • [ISO-abbreviation] J Mol Diagn
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Genetic Markers
  • [Other-IDs] NLM/ PMC1888495
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4. Kajiwara H, Osamura Y: [Trends in gastroenteropancreatic neuroendocrine tumors]. Nihon Geka Gakkai Zasshi; 2008 May;109(3):123-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The first edition of the WHO classification included neuroendocrine tumors of the digestive organs and pancreas, but thereafter it was pointed that neuroendocrine cells are distributed throughout the body and thus that carcinoids occur in various other organs.
  • The most recent edition of the WHO classification takes into account the occurrence of neuroendocrine tumors throughout the body.
  • In addition, carcinoids were originally thought to be variants of a benign tumor type with a low malignancy rate, but thereafter metastases were observed.
  • [MeSH-minor] Antineoplastic Agents, Hormonal / therapeutic use. Digestive System Surgical Procedures. Humans. Neoplasm Staging. Octreotide / therapeutic use. Receptors, Somatostatin. World Health Organization

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  • (PMID = 18536314.001).
  • [ISSN] 0301-4894
  • [Journal-full-title] Nihon Geka Gakkai zasshi
  • [ISO-abbreviation] Nihon Geka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Receptors, Somatostatin; RWM8CCW8GP / Octreotide
  • [Number-of-references] 12
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5. Shields CJ, Delaney CP, Winter DC, Young L, Gorey TF, Fitzpatrick JM: Induction of nitric oxide synthase is a key determinant of progression to pulmonary injury in experimental pancreatitis. Surg Infect (Larchmt); 2006 Dec;7(6):501-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Pancreatitis was induced in male Sprague-Dawley rats by intraperitoneal (i.p.) injection of 20% L-arginine (500 mg/100 g of body weight).
  • Pancreatic and pulmonary pathology, neutrophil infiltration (myeloperoxidase activity), endothelial permeability (bronchoalveolar lavage, wet:dry weight ratio), NOS expression, and concentrations of pro-inflammatory cytokines (tumor necrosis factor-alpha; interleukin-6) were assessed.
  • CONCLUSIONS: Inhibition of inducible NOS encourages a more benign immunologic profile, minimizing the deleterious effects of unrestrained neutrophil sequestration subsequent to pancreatitis.
  • [MeSH-minor] Animals. Enzyme Induction. Male. Nitric Oxide / metabolism. Pancreas / immunology. Pancreas / pathology. Rats. Rats, Sprague-Dawley

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  • (PMID = 17233567.001).
  • [ISSN] 1096-2964
  • [Journal-full-title] Surgical infections
  • [ISO-abbreviation] Surg Infect (Larchmt)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 31C4KY9ESH / Nitric Oxide; EC 1.14.13.39 / Nitric Oxide Synthase
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6. Hsu SD, Wu HS, Kuo CL, Lee YT: Robotic-assisted laparoscopic resection of ectopic pancreas in the posterior wall of gastric high body: case report and review of the literature. World J Gastroenterol; 2005 Dec 28;11(48):7694-6
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  • [Title] Robotic-assisted laparoscopic resection of ectopic pancreas in the posterior wall of gastric high body: case report and review of the literature.
  • We report here a case of ectopic pancreas tissue in the gastric wall that was removed using robotic-assisted laparoscopic resection.
  • Preoperative endoscopy revealed a submucosal lesion in the posterior wall of the gastric high body.
  • A robotic-assisted laparoscopic wedge resection of the putative gastric submucosal tumor was performed.
  • The pathology results showed an ectopic pancreas.
  • The patient had an uneventful recovery and we believe that this is a valid treatment option for this benign condition.
  • [MeSH-major] Choristoma / surgery. Laparoscopy / methods. Pancreas. Robotics. Stomach Diseases / surgery

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  • (PMID = 16437703.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4727226
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7. Suzuki S, Kaji S, Koike N, Harada N, Hayashi T, Suzuki M, Hanyu F, Ban S: Pancreatic schwannoma: a case report and literature review with special reference to imaging features. JOP; 2010;11(1):31-5
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  • CONTEXT: We report the imaging features of pancreatic schwannomas, a rare benign type of pancreatic tumor.
  • CASE REPORT: A 66-year-old woman was admitted to our hospital with a pancreatic tumor indicated in medical examinations.
  • Computed tomography (CT), magnetic resonance imaging (MRI) and endoscopic ultrasonography (EUS) revealed a solid and cystic tumor, 3 cm in diameter, within the body of the pancreas.
  • A distal pancreatectomy together with a splenectomy and lymph node dissection were performed with a tentative diagnosis of mucinous cystic neoplasm of the pancreas.
  • The cut surface of the resected pancreas showed a well-demarcated, pale yellow, solid tumor within the pancreas parenchyma.
  • Histopathological examination of the tumor revealed proliferation of the spindle cells showing interlacing and palisading patterns.
  • Thus the tumor was diagnosed as a pancreatic schwannoma.
  • Imaging procedures such as CT, MRI and US are able to differentiate a pancreatic tumor, such as a pancreatic schwannoma.

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  • (PMID = 20065549.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] K2I13DR72L / Gadolinium DTPA
  • [Number-of-references] 31
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8. Nakao A, Fernández-Cruz L: Pancreatic head resection with segmental duodenectomy: safety and long-term results. Ann Surg; 2007 Dec;246(6):923-8; discussion 929-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Recently, organ-preserving pancreatic resections for benign and noninvasive IPMN located in the head of the pancreas have been described.
  • Body weight was unchanged in 80% after PHRSD and in 59% after PPPD.
  • The 5-year survival rate was 100% in patients with benign IPMN and 42% in patients with invasive IPMN.
  • Long-term outcome was satisfactory without tumor recurrence in noninvasive carcinoma.
  • PHRSD should therefore be considered as an adequate operation as an organ-preserving pancreatic resection for branch-duct type of IPMN located at the head of the pancreas.

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  • [CommentIn] Ann Surg. 2008 Sep;248(3):498-9 [18791375.001]
  • (PMID = 18043093.001).
  • [ISSN] 0003-4932
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] United States
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9. Mou YP, Chen QL, Xu XW, Wang GY, Sun XD, Zhu LH, Zhu YP, Yang P: [Laparoscopic distal pancreatectomy with preservation of the spleen]. Zhonghua Wai Ke Za Zhi; 2006 Feb 1;44(3):200-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: From Nov 2003 to Dec 2004, 2 patients with cystic lesions in the body and tail of the pancreas underwent laparoscopic distal pancreatectomy with preservation of the spleen.
  • CONCLUSION: Laparoscopic distal pancreatectomy with preservation of the spleen is safe and feasible for the management of benign tumor in the body and tail of pancreas with the advantages of reduced injury, earlier recovery and less complication.

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  • (PMID = 16635353.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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10. Christein JD, Smoot RL, Farnell MB: Central pancreatectomy: a technique for the resection of pancreatic neck lesions. Arch Surg; 2006 Mar;141(3):293-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although historically used for traumatic pancreatic transection and chronic pancreatitis, it currently is reserved for selective management of pancreatic neck lesions that are benign or have low malignant potential.
  • Our objectives were to describe the technique and determine the safety and effectiveness of central pancreatectomy in the excision of benign or low-malignant potential lesions of the pancreatic neck.
  • INTERVENTION: Patients with pancreatic neck or proximal body masses underwent central pancreatectomy at the Mayo Clinic, Rochester, Minn.
  • Mean tumor size was 2.8 cm and mean operative time was 4.8 hours with a mean blood loss of 381 mL.
  • The precise role of central pancreatectomy in the management of benign or low-malignant potential lesions of the neck of the pancreas remains in evolution.
  • [MeSH-minor] Adenoma, Islet Cell / radiography. Adenoma, Islet Cell / surgery. Cystadenoma, Serous / radiography. Cystadenoma, Serous / surgery. Female. Humans. Liposarcoma / surgery. Male. Mesenteric Veins / surgery. Middle Aged. Neoplasm Recurrence, Local / surgery. Reoperation. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 16549696.001).
  • [ISSN] 0004-0010
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Stojanovic MP, Radojkovic M, Jeremic LM, Zlatic AV, Stanojevic GZ, Jovanovic MA, Kostov MS, Katic VP: Malignant schwannoma of the pancreas involving transversal colon treated with en-bloc resection. World J Gastroenterol; 2010 Jan 7;16(1):119-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant schwannoma of the pancreas involving transversal colon treated with en-bloc resection.
  • Pancreatic schwannoma is a very uncommon tumor of the pancreas, with only 27 cases reported.
  • Most pancreatic schwannomas are benign, with only four malignant tumors reported.
  • We describe a case of giant malignant schwannoma of the pancreatic body and tail, which involved the transverse colon.
  • The tumor was treated successfully with en bloc distal splenopancreatectomy and colon resection.
  • This is believed to be the first reported radical operation for malignant schwannoma of the pancreatic body, with infiltration of the transverse colon, with excellent long-term results.
  • The authors conclude that pancreatic schwannomas should be considered in the differential diagnosis of cystic neoplasms of the pancreas, although the diagnosis can only be confirmed by microscopic examination.
  • In the case of the benign tumors, local excision is adequate, but in the case of malignant schwannoma, oncological standards must be fulfilled.
  • [MeSH-minor] Biopsy. Female. Humans. Lymph Node Excision. Neoplasm Invasiveness. Splenectomy. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • (PMID = 20039458.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2799907
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12. Yang YS, Wang XD, Ji DG, Zhang D, Xie YJ, Meng ZH, Zhang XW: [Middle segment pancreatectomy for the benign tumors of the neck and body of the pancreas (report of 15 cases)]. Zhonghua Wai Ke Za Zhi; 2010 Sep 15;48(18):1402-4
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  • [Title] [Middle segment pancreatectomy for the benign tumors of the neck and body of the pancreas (report of 15 cases)].
  • OBJECTIVE: To study the clinical application value of middle segment pancreatectomy in the treatment of benign tumors of the amphi-neck of the pancreas.
  • They all received middle segment pancreatectomy for benign tumors of the amphi-neck of the pancreas.
  • Postoperative pathology showed that in the 15 patients, 1 got solid-pseudopapillary tumor of the pancreas, 3 got non-functional islet cell tumor, 11 got cystadenoma of pancreas.
  • CONCLUSIONS: There is an exact therapeutic effect of middle segment pancreatectomy for benign tumors of the amphi-neck of the pancreas.

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  • (PMID = 21092576.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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13. França SR, Caldas D, Alcebíades V 2nd, de Oliveira CA: [Mucoepidermoid carcinoma of the thyroid: a case report and literature review]. Arq Bras Endocrinol Metabol; 2006 Oct;50(5):968-76
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  • [Transliterated title] Carcinoma mucoepidermóide de tireóide: relato de caso e revisão da literatura.
  • The mucoepidermoid carcinoma is a neoplasia that usually occurs at salivary glands, breast, pancreas and gastrointestinal tract.
  • Although the majority of cases of mucoepidermoid carcinoma of the thyroid (MECT) show a benign evolution, this paper describes a patient with an aggressive tumor.
  • [MeSH-minor] Calcitonin / analysis. Female. Humans. Middle Aged. Mucins / metabolism. Neoplasm Recurrence, Local / pathology. Prognosis. Thyroid Gland / pathology. Thyroidectomy. Whole Body Imaging

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  • (PMID = 17160225.001).
  • [ISSN] 0004-2730
  • [Journal-full-title] Arquivos brasileiros de endocrinologia e metabologia
  • [ISO-abbreviation] Arq Bras Endocrinol Metabol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Mucins; 9007-12-9 / Calcitonin
  • [Number-of-references] 26
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14. Shintaku M, Arimoto A, Sakita N: Serous cystadenocarcinoma of the pancreas. Pathol Int; 2005 Jul;55(7):436-9
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  • [Title] Serous cystadenocarcinoma of the pancreas.
  • A case of serous cystadenocarcinoma of the pancreas in an 85-year-old woman is reported.
  • The tumor extensively involved the body and tail of the pancreas and contiguously invaded the spleen.
  • The histopathology of the tumor was similar to that of serous cystadenoma, but mild nuclear hyperchromatism and atypism were noted, and the neoplastic invasion of nerve fibers in the stroma was observed.
  • The present case is the second example of this kind of neoplasm that showed direct splenic invasion.
  • Because serous cystadenocarcinoma of the pancreas exhibits bland cytological features, diligent search for the invasion of the surrounding tissue or peripheral nerves is needed for the differentiation from its benign counterpart.
  • [MeSH-minor] Aged. Aged, 80 and over. CA-125 Antigen / analysis. CA-19-9 Antigen. Carcinoembryonic Antigen / analysis. Humans. Immunohistochemistry. Matrix Metalloproteinase 1 / analysis. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 15982220.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / CA-125 Antigen; 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen; 0 / Tumor Suppressor Protein p53; EC 3.4.24.7 / Matrix Metalloproteinase 1
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15. Kubo H, Nakamura K, Itaba S, Yoshinaga S, Kinukawa N, Sadamoto Y, Ito T, Yonemasu H, Takayanagi R: Differential diagnosis of cystic tumors of the pancreas by endoscopic ultrasonography. Endoscopy; 2009 Aug;41(8):684-9
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  • [Title] Differential diagnosis of cystic tumors of the pancreas by endoscopic ultrasonography.
  • Neoplastic cystic tumors include mucinous cystic neoplasm (MCN), intraductal papillary-mucinous neoplasm (IPMN), and serous cystic neoplasm (SCN).
  • MCNs and IPMNs have the potential to progress to a malignant state, whereas SCNs are known for their almost benign behavior.
  • Thus, in order to make management decisions, it is important to distinguish between potentially malignant (MCN and IPMN), and benign (SCN and NNC) tumors.
  • The aim of this study was to retrospectively investigate the value of endoscopic ultrasonography (EUS) for the differential diagnosis of cystic tumors of the pancreas.
  • PATIENTS AND METHODS: A total of 76 patients with cystic tumors of the pancreas were preoperatively examined by EUS.
  • The EUS findings relevant to distinguishing between potentially malignant and benign were analyzed statistically.
  • RESULTS: All patients with MCNs were female and all these tumors were located in the pancreatic body/tail.
  • In univariate analysis, age, tumor size, locularity, the number of cystic formation, cystic component, and appearance were significant variables.
  • CONCLUSIONS: The characteristics of cystic tumors of the pancreas revealed by EUS are useful for their differential diagnosis.

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  • (PMID = 19670136.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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16. Yang F, Jin C, Long J, Yu XJ, Xu J, Di Y, Li J, Fu de L, Ni QX: Solid pseudopapillary tumor of the pancreas: a case series of 26 consecutive patients. Am J Surg; 2009 Aug;198(2):210-5
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  • [Title] Solid pseudopapillary tumor of the pancreas: a case series of 26 consecutive patients.
  • OBJECTIVE: Solid pseudopapillary tumor (SPT) of the pancreas, which predominantly affects young women, is a relatively indolent entity with favorable prognosis.
  • Clinicopathologic factors were compared between benign and malignant cases to determine what features of the tumor could suggest malignant potential.
  • The neoplasm was localized in the pancreatic head/neck in 14 patients and in the body/tail in 12 patients.
  • CONCLUSIONS: SPT is a rare neoplasm with low malignant potential.

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  • (PMID = 19268906.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Jordán-Pérez B, Javier-Haro F, Gómez-Herrera E, Hermosillo-Sandoval JM, Andrade-Madrid R, Prieto-Díaz Chávez E: [Cystic neoplasms of the pancreas]. Cir Cir; 2008 Jul-Aug;76(4):299-303
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  • [Title] [Cystic neoplasms of the pancreas].
  • BACKGROUND: Cystic neoplasms of the pancreas represent between 5% and 10% of all pancreatic tumors.
  • Because of the uncommon nature of this pathology, the aim of this study was to present a series of six patients who were operated on for a cystic tumor and to analyze the morphological characteristics, surgical experience and follow-up.
  • Clinical files were studied, as well as surgical and pathological registries from patients diagnosed with cystic neoplasms of the pancreas.
  • In 4/6 patients, the tumor was located within the body and tail of the pancreas.
  • After a 4-year follow-up, no tumor recurrences have been reported in the surviving patients.
  • CONCLUSIONS: The natural history of cystic neoplasms of the pancreas is generally benign, but complications may occur by direct invasion of neighboring structures.

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  • (PMID = 18778539.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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18. Hirono S, Tani M, Kawai M, Ina S, Nishioka R, Miyazawa M, Fujita Y, Uchiyama K, Yamaue H: Treatment strategy for intraductal papillary mucinous neoplasm of the pancreas based on malignant predictive factors. Arch Surg; 2009 Apr;144(4):345-9; discussion 349-50
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  • [Title] Treatment strategy for intraductal papillary mucinous neoplasm of the pancreas based on malignant predictive factors.
  • Identification of predictive factors for differentiating IPMC from benign IPMNs would assist in providing appropriate treatment.
  • PATIENTS: Fifty-four patients with IPMN who underwent surgery; histologic examination showed benign adenomas in 29, carcinoma in situ in 14, and invasive carcinoma in 11 patients.
  • MAIN OUTCOME MEASURES: Clinical data, preoperative imaging findings, cytologic findings, tumor markers in serum and pancreatic juice, and overall survival.
  • The presence of jaundice or body weight loss, main pancreatic duct type, presence of mural nodules, mural nodule size of 5 mm or larger, and CEA level in the pancreatic juice of 110 ng/mL or higher were all predictive of invasive IPMCs by univariate analysis.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Prognosis. Survival Rate

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  • (PMID = 19380648.001).
  • [ISSN] 1538-3644
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Heni M, Schott S, Horger M, Dudziak K, Thamer C, Häring HU, Fritsche A, Müssig K: [A rare cause of hypoglycaemia in a patient with type 2 diabetes]. Dtsch Med Wochenschr; 2009;134 Suppl Falldatenbank:F2
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  • Magnetic resonance imaging and selective arterial calcium stimulation test confirmed a mass in the body of the pancreas.
  • The tumor was removed surgically.
  • Pathological examination demonstrated a benign insulinoma.


20. Miura T, Igarashi Y, Okano N, Miki K, Okubo Y: Endoscopic diagnosis of intraductal papillary-mucinous neoplasm of the pancreas by means of peroral pancreatoscopy using a small-diameter videoscope and narrow-band imaging. Dig Endosc; 2010 Apr;22(2):119-23
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  • [Title] Endoscopic diagnosis of intraductal papillary-mucinous neoplasm of the pancreas by means of peroral pancreatoscopy using a small-diameter videoscope and narrow-band imaging.
  • BACKGROUND: Intraductal papillary-mucinous neoplasm (IPMN) is an intraductal tumor in which the mucin-producing epithelium shows proliferated papillary and a wide variety of pathological changes ranging from hyperplasia to adenocarcinoma.
  • Therefore, it is important to determine whether an IPMN is benign or malignant.
  • We carried out the differential diagnosis of benign lesion to malignant lesion.
  • RESULTS: Fifteen focal lesions of the 16 cases in the head of the pancreas (93.7%) and four focal lesions of the five cases in the pancreatic body (80%) were observable, whereas two lesions (adenocarcinoma in the pancreatic body, and adenoma in the uncus of pancreas) were not observable.
  • CONCLUSIONS: When combined with a videoscope and NBI, pancreatoscopy provided a clear image and was useful for evaluating whether the IPMN was benign or malignant.

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  • (PMID = 20447205.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] Australia
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21. Stern JR, Frankel WL, Ellison EC, Bloomston M: Solid serous microcystic adenoma of the pancreas. World J Surg Oncol; 2007;5:26
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  • [Title] Solid serous microcystic adenoma of the pancreas.
  • BACKGROUND: Cystic neoplasms of the pancreas are less common than solid tumors, and portend a better prognosis.
  • They can be divided into serous and mucinous subtypes, with the former behaving less aggressively and generally considered benign.
  • CASE PRESENTATION: We present a case of a 62 year-old man with a history of abdominal pain, who on CT scan was found to have a solid mass at the junction of the head and body of the pancreas.
  • It appears to behave in a benign manner, and as such, surgical resection is curative for patients with this tumor.
  • Furthermore, until more cases of solid SMA are identified to further elucidate its natural history and improve the reliability of preoperative diagnosis, surgical resection of this solid pancreatic tumor should be considered standard therapy in order to exclude malignancy.
  • [MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Biopsy, Needle. Follow-Up Studies. Humans. Immunohistochemistry. Laparoscopy / methods. Male. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Staging. Rare Diseases. Risk Assessment. Splenectomy / methods. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17338818.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1821026
  • [General-notes] NLM/ Original DateCompleted: 20070810
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22. Kang CM, Lee JW: Spleen preserving laparoscopic distal pancreatectomy with segmental resection of splenic artery in a solid pseudo papillary tumor of the pancreas. Hepatogastroenterology; 2009 Jul-Aug;56(93):1207-10
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  • [Title] Spleen preserving laparoscopic distal pancreatectomy with segmental resection of splenic artery in a solid pseudo papillary tumor of the pancreas.
  • Laparoscopic distal pancreatectomy is suitable for benign and premalignant neoplasms located in the body and tail of the pancreas.
  • In addition, spleen-preservation following distal pancreatectomy for benign or low-grade malignant disease is known to be safe.
  • We present a case of 32-year-old female patient with a solid pseudopapillary tumor of the pancreas treated by spleen-preserving laparoscopic distal pancreatectomy with segmental resection of the splenic artery and splenic vein intact.

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  • (PMID = 19760971.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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23. Demirci H, Erdamar H, Karakoc A, Akturk M, Yilmaz M, Arslan M: CA 72-4 levels in patients with type 2 diabetes mellitus. Int J Clin Pract; 2010 Jan;64(1):34-8
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  • OBJECTIVE: CA 72-4 is one of the blood group carbohydrate antigens which can be used as a tumour marker in ovarian, pancreatic and gastrointestinal carcinomas.
  • It can also be elevated in various benign conditions including pancreatitis.
  • Diabetes mellitus is a chronic disorder related with the pancreas.
  • There was no association between CA 72-4 levels and age and sex of the patients, duration of diabetes, body mass index, biochemical indicators of metabolic control (the levels of HbA(1c), fasting and postprandial glucose, serum lipids), the presence of microvascular complications (retinopathy, nephropathy, neuropathy) or treatment modalities.
  • [MeSH-major] Antigens, Tumor-Associated, Carbohydrate / metabolism. Diabetes Mellitus, Type 2 / immunology. Diabetic Angiopathies / immunology

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  • (PMID = 18205795.001).
  • [ISSN] 1742-1241
  • [Journal-full-title] International journal of clinical practice
  • [ISO-abbreviation] Int. J. Clin. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Tumor-Associated, Carbohydrate; 0 / Blood Glucose; 0 / CA-72-4 antigen; 0 / Hemoglobin A, Glycosylated; 0 / Hypoglycemic Agents; 0 / Insulin; 0 / Lipids
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24. Colovic RB, Grubor NM, Micev MT, Atkinson HD, Rankovic VI, Jagodic MM: Cystic lymphangioma of the pancreas. World J Gastroenterol; 2008 Nov 28;14(44):6873-5
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  • [Title] Cystic lymphangioma of the pancreas.
  • Lymphangioma of the pancreas is an extremely rare benign tumour of lymphatic origin, with fewer than 60 published cases.
  • Complete excision is curative, even though, depending on the tumour location, surgery may be simple or involve extensive pancreatic resection and anastomoses.
  • The authors present a 49-year-old woman in whom a polycystic septated mass, 35 mm multiply 35 mm in size, was discovered by ultrasonography (US) in the body of the pancreas during investigations for epigastric pain and nausea.
  • At surgery, a well circumscribed polycystic tumor was completely excised, with preservation of the pancreatic duct.
  • Histology confirmed a microcystic lymphangioma of the pancreas.
  • Although extremely rare, lymphangioma of the pancreas should be taken into consideration as a differential diagnosis of a pancreatic cystic lesion, especially in women.

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  • (PMID = 19058318.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 15
  • [Other-IDs] NLM/ PMC2773887
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25. Ishimori T, Patel PV, Wahl RL: Detection of unexpected additional primary malignancies with PET/CT. J Nucl Med; 2005 May;46(5):752-7
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  • This study evaluated the yield of whole-body (18)F-FDG PET/CT for the detection of unexpected (18)F-FDG-avid additional primary malignant tumors in patients being evaluated by PET/CT for known or suspected malignances.
  • METHODS: Reports from whole-body (18)F-FDG PET/CT scans from June 2001 to June 2003 were reviewed, and 1,912 patients (924 men and 988 women; mean age +/- SD, 58.9 +/- 13.9 y) who had been scanned for known or suspected malignant lesions were included in this study.
  • The sites of known or suspected primary tumors included lung (28.6%), colon or rectum (12.4%), head or neck (12.1%), lymph nodes (10.9%), breast (7.6%), gynecologic organs (7.1%), genitourinary organs (4.2%), esophagus (3.6%), skin (melanoma) (3.5%), pancreas (2.5%), bone or soft tissue (2.2%), and other sites (5.4%).
  • Lesions that were newly discovered on PET/CT, had not been previously detected by other modalities, and were atypical in location for metastases on the PET/CT study were interpreted as suggestive of a new primary malignant tumor.
  • In 8 patients, the PET-positive lesions were considered benign after clinical follow-up of at least 8 mo.
  • CONCLUSION: Whole-body PET/CT detected new, unexpected (18)F-FDG-avid primary malignant tumors in at least 1.2% of patients with cancer.
  • [MeSH-major] Neoplasms, Multiple Primary / epidemiology. Neoplasms, Multiple Primary / radionuclide imaging. Positron-Emission Tomography / statistics & numerical data. Tomography, X-Ray Computed / statistics & numerical data. Whole-Body Counting / statistics & numerical data

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  • (PMID = 15872346.001).
  • [ISSN] 0161-5505
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Wu M, Yuan S, Szporn AH, Gan L, Shtilbans V, Burstein DE: Immunocytochemical detection of XIAP in body cavity effusions and washes. Mod Pathol; 2005 Dec;18(12):1618-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunocytochemical detection of XIAP in body cavity effusions and washes.
  • Body cavity effusions may be the first manifestation of malignancy or of recurrence or relapse.
  • We performed an immunocytochemical survey of XIAP expression in cell blocks from benign and malignant body cavity effusions and washes.
  • The prevalence of staining for specific malignancies varied with the tissue of origin as follows: ovarian (13/13, 100%); lung (9/11, 82%), breast (6/13, 46%); gastric (4/7, 57%), colon (0/4, 0%), pancreas (2/3, 67%), gallbladder (1/1, 100%), fallopian tube (1/3, 33%), endometrial (6/7, 86%), mesothelioma (4/5, 80%), carcinoma of unknown primary (5/5, 100%) and hematopoietic malignancies (3/9, 33%).
  • Benign effusions (n = 35) were virtually XIAP-negative except for two cases (6%) in which histiocytes showed moderate staining.
  • XIAP immunostaining, when strong, allows for ready distinction of malignant from benign and reactive cell populations.
  • The degree of XIAP staining of tumor cells may be a means of identifying the most therapy-resistant cases (ie, those with strong XIAP expression), and allow additional triaging to XIAP-blocking drugs presently being developed and clinically tested.
  • [MeSH-major] Ascitic Fluid / chemistry. Biomarkers, Tumor / analysis. Immunoenzyme Techniques / methods. Peritoneal Lavage. Pleural Effusion, Malignant / chemistry. X-Linked Inhibitor of Apoptosis Protein / analysis

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  • (PMID = 16118627.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / X-Linked Inhibitor of Apoptosis Protein
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27. Merchant NB, Parikh AA, Kooby DA: Should all distal pancreatectomies be performed laparoscopically? Adv Surg; 2009;43:283-300
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • There are both enough experience and data (though retrospective) to confirm that LDP with or without spleen preservation appears to be a safe treatment for benign or noninvasive lesions of the pancreas.
  • Based on the fact that LDP can be performed with similar or shorter operative times, blood loss, complication rates, and length of hospital stay than ODP, it can be recommended as the treatment of choice for benign and noninvasive lesions in experienced hands when clinically indicated.
  • While this report is underpowered, it supports the notion that MIS cancer surgery may induce less of a systemic insult to the body than standard open cancer surgery.
  • Can we enucleate a small tumor off the pancreatic body by passing an endoscope through the gastric (or colonic) wall, and bring the specimen out via the mouth or anus?

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  • (PMID = 19845186.001).
  • [ISSN] 0065-3411
  • [Journal-full-title] Advances in surgery
  • [ISO-abbreviation] Adv Surg
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 95
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28. Uehara H, Tatsumi K, Masuda E, Kato M, Kizu T, Ishida T, Takakura R, Takano Y, Nakaizumi A, Ishikawa O, Takenaka A: Scraping cytology with a guidewire for pancreatic-ductal strictures. Gastrointest Endosc; 2009 Jul;70(1):52-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PATIENTS AND METHODS: Eighty-six patients with pancreatic-ductal strictures composed of 71 malignant and 15 benign diseases were evaluated.
  • Malignant diseases included 70 pancreatic carcinomas and 1 endocrine tumor; benign diseases included the following: 7 chronic pancreatitis, 3 autoimmune pancreatitis, 3 idiopathic pancreatic-ductal strictures, and 2 pancreatic cysts.
  • Sensitivities for pancreatic carcinoma in the head, body, and tail of the pancreas were 91%, 100%, and 91%, respectively.
  • Sensitivities for pancreatic carcinoma with a tumor of <20 mm, 21 to 40 mm, 41 to 60 mm, and >61 mm were 95%, 92%, 100%, and 100%, respectively.
  • CONCLUSIONS: Benign or malignant pancreatic-ductal strictures were accurately discriminated by scraping cytology with a guidewire during ERCP.
  • The technique yielded high diagnostic sensitivities in pancreatic carcinoma, regardless of the location or size of the tumor.

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  • (PMID = 19249043.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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29. Usukura M, Yoneda T, Oda N, Yamamoto Y, Takata H, Hasatani K, Takeda Y: Medical treatment of benign insulinoma using octreotide LAR: a case report. Endocr J; 2007 Feb;54(1):95-101
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  • [Title] Medical treatment of benign insulinoma using octreotide LAR: a case report.
  • In some patients with insulinoma, surgery is not possible due to either difficulties in detecting the tumor or advanced age.
  • We report a case of benign insulinoma using the long-acting octreotide formulation, octreotide long-acting repeatable (octreotide LAR), as a medical therapy.
  • An abdominal CT scan demonstrated a hypervascular tumor in the body of pancreas.
  • As the patient refused surgical resection of the pancreas tumor, we started to use the somatostatin analogue, octreotide, for treatment of hypoglycemia.

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  • (PMID = 17124362.001).
  • [ISSN] 0918-8959
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Blood Glucose; 0 / Delayed-Action Preparations; 0 / Hemoglobin A, Glycosylated; 0 / Hemoglobins; 0 / Insulin; 0 / hemoglobin A1c protein, human; RWM8CCW8GP / Octreotide
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30. Ge C, Luo X, Chen X, Guo K: Enucleation of pancreatic cystadenomas. J Gastrointest Surg; 2010 Jan;14(1):141-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • (1) the benign nature of the tumors was ascertained preoperatively and intraoperatively, (2) small tumors or larger tumors no more than 6 cm in diameter growing outwardly with small tumor beds, and (3) the main pancreatic duct was not in jeopardy of damage by enucleation.
  • The patients' demographics, tumor features, morbidity, and follow-up results were retrospectively reviewed and analyzed.
  • All cases were followed up from 23 to 67 months, which revealed no neoplasm recurrence or new onset of diabetes mellitus; one patient developed a pseudocyst in the body 30 months after enucleation.
  • CONCLUSIONS: It is safe and effective to perform enucleation for well-selected benign pancreatic cystadenomas even if the tumor size is as large as 6 cm, and the endocrine or exocrine function of the pancreas is maintained as much as possible.

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  • (PMID = 19779948.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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31. Singh N, Lo CY, Chan WF: Laparoscopic enucleation of a nonfunctioning neuroendocrine tumor at the head of the pancreas. JSLS; 2006 Apr-Jun;10(2):259-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic enucleation of a nonfunctioning neuroendocrine tumor at the head of the pancreas.
  • OBJECTIVE: Laparoscopy is a safe, feasible technique for benign pancreatic pathologies and has been increasingly reported for neuroendocrine tumors located at the body and tail of the pancreas.
  • We report a case of successful enucleation of a nonfunctioning neuroendocrine tumor located at the head of the pancreas, in a patient with multiple endocrine neoplasia type I.
  • METHODS: A 5-cm nonfunctioning neuroendocrine tumor at the pancreatic head was identified by computerized tomography scan.
  • Laparoscopic ultrasound did not reveal additional tumors on any other part of the pancreas.
  • RESULTS: Enucleation was successfully performed for this solitary tumor because of its favorable position.
  • Histology revealed an islet cell tumor.
  • CONCLUSION: Laparoscopic enucleation of neuroendocrine tumor at the pancreatic head is safe and feasible for select patients.

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  • (PMID = 16882434.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3016133
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32. Shimada K, Sakamoto Y, Esaki M, Kosuge T, Hiraoka N: Role of medial pancreatectomy in the management of intraductal papillary mucinous neoplasms and islet cell tumors of the pancreatic neck and body. Dig Surg; 2008;25(1):46-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of medial pancreatectomy in the management of intraductal papillary mucinous neoplasms and islet cell tumors of the pancreatic neck and body.
  • BACKGROUND/AIM: Medial pancreatectomy has been applied as a safe and effective alternative in benign diseases located in the pancreatic neck or body.
  • Three patients with islet cell tumor and 1 patient with solid pseudopapillary tumor had no malignant disease.
  • CONCLUSIONS: A medial pancreatectomy is a safe and effective alternative for the treatment of intraductal papillary mucinous neoplasm, islet cell tumor, or solid pseudopapillary tumor located in the neck or body of the pancreas.

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  • (PMID = 18292661.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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33. Matsumoto T, Hirano S, Yada K, Shibata K, Sasaki A, Kamimura T, Ohta M, Kitano S, Kashima K: Malignant serous cystic neoplasm of the pancreas: report of a case and review of the literature. J Clin Gastroenterol; 2005 Mar;39(3):253-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant serous cystic neoplasm of the pancreas: report of a case and review of the literature.
  • BACKGROUND: In general, serous cystic neoplasms of the pancreas are thought to be benign.
  • Malignant serous cystic neoplasm of the pancreas is a rare clinical entity.
  • CASE REPORT: We report the case of an 87-year-old woman with a serous microcystic neoplasm in the tail of the pancreas that behaved in a malignant fashion.
  • The neoplasm had also invaded the colonic mesentery and splenic hilum.
  • The pancreatic lesion was diagnosed as a large malignant serous cystic neoplasm, and the patient underwent distal pancreatectomy with splenectomy and segmental colectomy.
  • The resected specimen contained a large tumor, 12 x 9 x 8 cm, which occupied the body and tail of the pancreas.
  • Histologically, the tumor was indistinguishable from serous cystadenoma.
  • However, the tumor had invaded surrounding tissues including the splenic vein, and there were splenic invasion and a regional lymph node metastasis.
  • DISCUSSION: There are few reported cases of malignant serous cystic neoplasm, in which malignancy was histologically confirmed in the resected specimen.
  • There are no reports of a negative outcome with complete resection of the tumor.

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  • (PMID = 15718870.001).
  • [ISSN] 0192-0790
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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34. Dai MH, Zhao YP, Liao Q, Liu ZW, Guo JC, Cong L: [Laparoscopic distal pancreatectomy: current indications and surgical results]. Zhonghua Wai Ke Za Zhi; 2006 Aug 1;44(15):1022-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • 2005 with diagnosis of masses located at pancreatic body/tail.
  • Preoperative diagnosis: nine patients with cystic lesion located at pancreatic body and tail, one patient with pancreatic endocrine tumor with liver metastasis, which located at pancreatic tail.
  • The mean size of the tumor was 4.0 cm.
  • The serum levels of tumor markers (including CA19-9, CA242, CA50 and CEA) of the patients were all normal.
  • During the follow-up, nine patients with benign cystic lesions did not relapse.
  • CONCLUSIONS: Laparoscopic distal pancreatectomy was safe and feasible for benign cystic tumors located at the body or tail of the pancreas.

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  • (PMID = 17074236.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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35. Kobayashi T, Shimura T, Araki K, Ogawa A, Mochida Y, Suzuki H, Suehiro T, Kuwano H: Lymphoepithelial cyst of the pancreas: report of a case. Hepatogastroenterology; 2008 May-Jun;55(84):1107-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lymphoepithelial cyst of the pancreas: report of a case.
  • The aim of this report is to describe the clinical and pathological features of a lympoepithelial cyst of the pancreas and to recommend fine-needle aspiration biopsy for the differential diagnosis of this lesion.
  • A 55-year-old man was incidentally diagnosed as having a pancreatic tumor by abdominal ultrasonography.
  • A hypoechoic cystic lesion was detected on the surface of the pancreatic body.
  • The lesion was diagnosed as a benign cystic tumor, and enucleation of the tumor was scheduled.
  • The postoperative pathological diagnosis was a lymphoepithelial cyst of the pancreas.
  • This cyst is an unusual but benign mass that requires minimal surgery.
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Epithelium / pathology. Humans. Laparoscopy. Lymphoid Tissue / pathology. Magnetic Resonance Imaging. Male. Middle Aged. Pancreas / pathology. Pancreas / surgery. Tomography, X-Ray Computed

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  • (PMID = 18705339.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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36. Kitagawa H, Okabayashi T, Nishimori I, Kobayashi M, Sugimoto T, Akimori T, Kohsaki T, Miyaji E, Onishi S, Araki K: Rapid growth of mucinous cystic adenoma of the pancreas following pregnancy. Int J Gastrointest Cancer; 2006;37(1):45-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rapid growth of mucinous cystic adenoma of the pancreas following pregnancy.
  • At 8 mo postpartum, she became aware of an upper abdominal tumor.
  • Abdominal computed tomography and upper abdominal ultrasonography revealed a large cystic mass in the body of the pancreas.
  • The patient underwent tumor resection at 11 mo postpartum.
  • Pathological examination of the tumor revealed mucin-producing columnar epithelial cells lining the cystic wall with ovarian-type stromal tissue and no findings indicative of malignancy, giving a diagnosis of mucinous cystic adenoma of the pancreas.
  • Postpartum rapid growth of a benign mucinous cystic neoplasm might be linked to the production of female sex hormones during lactation.

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  • (PMID = 17290080.001).
  • [ISSN] 1537-3649
  • [Journal-full-title] International journal of gastrointestinal cancer
  • [ISO-abbreviation] Int J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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37. Guo KJ, Song SW, Zhao MF, Ge CL, Xu YH, Ma G, Meng FB, Guo RX, Tian YL: [Indications, technique and efficacy of organ preserving pancreatectomy]. Zhonghua Wai Ke Za Zhi; 2010 Sep 15;48(18):1375-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To discuss the proper surgical management of pancreatic benign and low-grade malignant potential neoplasm.
  • There were 9 cases underwent duodenum-preserving resection of the head of the pancreas, 29 cases underwent spleen-preserving distal pancreatectomy, 11 cases underwent middle segmental pancreatectomy, 23 cases underwent tumor extirpation of huge pancreatic cancer in pancreatic head and body.
  • RESULTS: Pancreatic fistula and biliary fistula in 1 case respectively were cured among who accepted duodenum-preserving resection of the head of the pancreas.
  • Pancreatic fistula was found in 5 cases among who accepted tumor extirpation of huge pancreatic cancer in pancreatic head and body, and liver metastasis was found in 3 cases at 6, 12, 16 months after surgery respectively.
  • CONCLUSIONS: Organ preserving pancreatectomy can obviously reduce operative injury to patients, its therapeutic effect is similar to that of classical operation, it is the first option of benign and low-grade malignant potential neoplasm.

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  • (PMID = 21092570.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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38. Oku T, Maeda M, Wada Y, Waga E, Ono K, Nagamachi Y, Fujii S, Fujita M, Misu K, Senmaru N, Suzuki Y, Nagashima K, Niitsu Y: Intraductal oncocytic papillary neoplasm having clinical characteristics of mucinous cystic neoplasm and a benign histology. JOP; 2007;8(2):206-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraductal oncocytic papillary neoplasm having clinical characteristics of mucinous cystic neoplasm and a benign histology.
  • CONTEXT: An intraductal oncocytic papillary neoplasm is a rare pancreatic tumor which was first described by Adsay et al. in 1996.
  • Imaging studies revealed a cystic mass in the body of the pancreas.
  • The cellular atypism was mild and the proliferating index was low, compatible with adenoma of an intraductal oncocytic papillary neoplasm.
  • Although no ovarian type stroma was identified, in our case, no communication to main pancreatic duct (located in the pancreatic body) and rapid growth by intracystic hemorrhage were clinical characteristics of a mucinous cystic neoplasm, but not IPMN.
  • CONCLUSION: With only 17 cases reported to date, the clinical and pathological details of an intraductal oncocytic papillary neoplasm are still unclear.
  • To our knowledge, this is the first case report of an intraductal oncocytic papillary neoplasm with the clinical characteristics of a mucinous cystic neoplasm.

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  • (PMID = 17356245.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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39. Hayashibe A, Sakamoto K, Shinbo M, Makimoto S, Nakamoto T: A resected case of multiple intraductal papillary mucinous tumors of the pancreas with US-guided ductal branch-oriented partial pancreatectomy. Pancreatology; 2005;5(4-5):462-5
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  • [Title] A resected case of multiple intraductal papillary mucinous tumors of the pancreas with US-guided ductal branch-oriented partial pancreatectomy.
  • The cystic tumor of pancreas head had a diameter of 2 cm, and the mural nodule of the cystic tumor measured only 3 mm.
  • In the pancreas body the cystic tumor was measured at 1.5 cm with the mural nodule of the cystic tumor measuring 3 mm.
  • It was believed that the tumors were benign.
  • The operation was successful, and the histopathological diagnosis of the tumors was intraductal papillary adenoma of the pancreas.

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  • [Copyright] Copyright 2005 S. Karger AG, Basel and IAP.
  • (PMID = 15985773.001).
  • [ISSN] 1424-3903
  • [Journal-full-title] Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
  • [ISO-abbreviation] Pancreatology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Mucins
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40. Kang CM, Choi SH, Hwang HK, Kim DH, Yoon CI, Lee WJ: Laparoscopic distal pancreatectomy with division of the pancreatic neck for benign and borderline malignant tumor in the proximal body of the pancreas. J Laparoendosc Adv Surg Tech A; 2010 Sep;20(7):581-6
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  • [Title] Laparoscopic distal pancreatectomy with division of the pancreatic neck for benign and borderline malignant tumor in the proximal body of the pancreas.
  • BACKGROUND: Conventional laparoscopic distal pancreatectomy (DP) is now regarded as a safe, effective treatment modality; however, pancreatic transections are mostly believed to be somewhere between the body and tail of the pancreas.
  • PATIENTS AND METHODS: Ten patients underwent laparoscopic STP with pancreatic division at the level of SMV-SV-PV confluence for benign and borderline pancreatic disease.
  • All patients had benign or borderline malignant tumors in the body near the neck of the pancreas, with a median tumor size of 3 cm (range, 1-9.2).
  • In a comparative study with laparoscopic DP, the longer segment of resected pancreas (P < 0.001), smaller amount of blood loss (P = 0.019), and high rate of spleen preservation (P = 0.019) were also noted in the laparoscopic STP group.
  • [MeSH-minor] Adult. Aged. Female. Humans. Laparoscopy. Male. Middle Aged. Pancreas / surgery. Pancreatic Neoplasms / surgery. Retrospective Studies. Young Adult

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  • (PMID = 20629517.001).
  • [ISSN] 1557-9034
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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41. Toniato A, Meduri F, Foletto M, Avogaro A, Pelizzo M: Laparoscopic treatment of benign insulinomas localized in the body and tail of the pancreas: a single-center experience. World J Surg; 2006 Oct;30(10):1916-9; discussion 1920-1
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  • [Title] Laparoscopic treatment of benign insulinomas localized in the body and tail of the pancreas: a single-center experience.
  • RESULTS: Successful laparoscopic resection was performed in 11 out of 12 patients: 4 had tumor enucleation, and 7 had distal pancreatectomy; among these latter 5 had spleen-preserving distal pancreatectomy.
  • The median tumor size was 18 mm, and all the insulinomas were benign.
  • CONCLUSIONS: The laparoscopic approach proved to be feasible and safe, although the average operative time was longer and demanded good surgical skills as well as precise localization of the tumor and definition of its nature.
  • Tumors located in the body or tail of the pancreas that are benign in nature can better benefit of laparoscopic approach.
  • [MeSH-major] Insulinoma / surgery. Laparoscopy. Pancreas. Pancreatectomy / methods. Pancreatic Neoplasms / surgery

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  • [Cites] Langenbecks Arch Surg. 2005 Apr;390(2):134-40 [15609056.001]
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  • (PMID = 16855802.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Liu H, Peng C, Zhang S, Wu Y, Fang H, Sheng H, Peng S: Strategy for the surgical management of insulinomas: analysis of 52 cases. Dig Surg; 2007;24(6):463-70
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  • Forty-eight patients with benign lesions underwent surgical treatment: 41 patients open and 7 patients laparoscopic procedures.
  • Four patients with malignant insulinomas underwent tumor resection; 3 of them underwent metastatic lesion and/or lymph node dissection.
  • On follow-up, 86% of the patients were free from symptoms, and surgical cure was achieved in 95% of the patients with benign insulinomas.
  • CONCLUSIONS: The choice of the surgical strategy for the treatment of pancreatic insulinomas depends on size and location of the tumor and the risk of malignancy.
  • The laparoscopic approach is safe and feasible for patients with benign tumors located in body or tail of the pancreas.

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  • [Copyright] Copyright (c) 2007 S. Karger AG, Basel
  • (PMID = 18057893.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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43. Ichimura T, Kondo S, Okamura K, Tanaka E, Hirano S: Total parenchymal pancreatectomy preserving the duodenum, choledochus and spleen for widespread intraductal papillary mucinous neoplasm: report of a case. Hepatogastroenterology; 2010 Jan-Feb;57(97):8-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Total parenchymal pancreatectomy preserving the duodenum, choledochus and spleen for widespread intraductal papillary mucinous neoplasm: report of a case.
  • For patients with benign or low malignant diseases of the pancreas, several organ-preserving surgical techniques of pancreatectomy have been presented for localized lesions.
  • In cases of widespread or multifocal neoplasms of the pancreas, however, it is difficult to treat with this limited pancreatectomy because of a possible risk of residual dysplastic foci.
  • We herein report a patient with widespread intraductal papillary mucinous neoplasm treated successfully with total parenchymal pancreatectomy.
  • A 73-year-old man was diagnosed as main duct intraductal papillary mucinous neoplasm.
  • A papillary tumor was located in the body of the pancreas, and intraepithelial spreading reached almost the end of the pancreas tail and nearly over the midpoint of the pancreas head.
  • We performed total parenchymal pancreatectomy, an initial surgical procedure in which almost all parenchyma of the pancreas was resected but the duodenum, the common bile duct and the spleen were preserved and no reconstruction was needed.

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  • (PMID = 20422863.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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44. Cross SE, Jin YS, Rao J, Gimzewski JK: Nanomechanical analysis of cells from cancer patients. Nat Nanotechnol; 2007 Dec;2(12):780-3
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  • Using atomic force microscopy, we report the stiffness of live metastatic cancer cells taken from the body (pleural) fluids of patients with suspected lung, breast and pancreas cancer.
  • Within the same sample, we find that the cell stiffness of metastatic cancer cells is more than 70% softer, with a standard deviation over five times narrower, than the benign cells that line the body cavity.
  • [MeSH-minor] Elasticity. Hardness. Humans. Stress, Mechanical. Tumor Cells, Cultured

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  • [CommentIn] Nat Nanotechnol. 2009 Feb;4(2):72; author reply 72-3 [19197298.001]
  • (PMID = 18654431.001).
  • [ISSN] 1748-3395
  • [Journal-full-title] Nature nanotechnology
  • [ISO-abbreviation] Nat Nanotechnol
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / 5 R21GM074509; United States / NCI NIH HHS / CA / U01CA96116
  • [Publication-type] Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
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45. Katabami T, Kato H, Shirai N, Naito S, Saito N: Successful long-term treatment with once-daily injection of low-dose octreotide in an aged patient with insulinoma. Endocr J; 2005 Oct;52(5):629-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Contrast abdominal computed tomography revealed a tumor in the body of the pancreas with blushing during the early phase, and insulinoma was diagnosed.
  • Few reports have described long-term octreotide administration for benign insulinoma.

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  • (PMID = 16284444.001).
  • [ISSN] 0918-8959
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Insulin; RWM8CCW8GP / Octreotide
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46. Ikenaga N, Yamaguchi K, Konomi H, Fujii K, Sugitani A, Tanaka M: A minute nonfunctioning islet cell tumor demonstrating malignant features. J Hepatobiliary Pancreat Surg; 2005;12(1):84-7
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  • [Title] A minute nonfunctioning islet cell tumor demonstrating malignant features.
  • We report a patient with a minute nonfunctioning islet cell tumor, 8 mm in diameter, which demonstrated malignant features by histology.
  • Ultrasonography and computed tomography demonstrated a well-defined pancreatic tumor, 8 mm in diameter, in the body of the pancreas.
  • Serum levels of pancreatic hormones were within normal limits, and thus a tentative diagnosis was nonfunctioning islet cell tumor.
  • The size of the tumor remained unchanged for 1 1/2 years, but, at this time, the serum level of CA19-9 was elevated to 253 U/ml.
  • The resected specimen showed an endocrine tumor invading both the pancreatic parenchyma and the perineural spaces outside the tumor.
  • In general, minute nonfunctioning islet cell tumors have been considered to be completely benign, but the present tumor showed clear malignant features.
  • We might have to take surgical resection into consideration even if the size of such an endocrine tumor is minute.

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  • (PMID = 15754106.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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47. Celis Zapata J, Berrospi Espinoza F, Ruiz Figueroa E, Payet Meza E, Chavez Passiuri I, Young Tabusso F: [Central pancreatectomy. Indications and perisurgical results of a pancreatic tissue conservation technique]. Rev Gastroenterol Peru; 2005 Oct-Dec;25(4):349-55
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  • [Transliterated title] Pancreatectomia central: Indicaciones y resultados peri operatorios de una técnica de conservación de tejido pancreático.
  • INTRODUCTION: Proximal or distal pancreatectomy is the standard treatment for non-resectable benign pancreatic tumors.
  • PURPOSE: Report our experience in central pancreatectomy for the treatment of benign/low malignancy potential tumors in the body and neck of the pancreas by emphasizing the indications and perisurgical results.
  • METHODS: Prospective study of patients with suspected benign tumors in the body of pancreas.
  • SURGICAL TECHNIQUE: Resection of central pancreas through a Roux-en-Y pancreatojejunal anastomosis.
  • 6 benign tumors were found in the islets of Langerhans: 3 microcystic cystadenomas, 1 mucinous cystadenoma, 1 pseudopapillary solid tumor, and 1 serous cystadenoma.
  • CONCLUSION: Some selected cases of benign/low malignancy potential tumors may be treated with central pancreatectomy and pancreatojejunal anastomosis with acceptable morbidity levels and minimum mortality levels.
  • The benefit from preserving the greatest extension of healthy pancreatic tissue as possible is translated into a preservation of the endocrine and exocrine functions of the pancreas.

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  • (PMID = 16333390.001).
  • [ISSN] 1022-5129
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Peru
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48. Shikano T, Nakao A, Kodera Y, Yamada S, Fujii T, Sugimoto H, Kanazumi N, Nomoto S, Takeda S: Middle pancreatectomy: safety and long-term results. Surgery; 2010 Jan;147(1):21-9
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  • BACKGROUND: Pancreaticoduodenectomy and distal pancreatectomy for lesions of the neck or body of the pancreas sacrifice a large amount of normal pancreatic tissue.
  • METHOD: Twenty-six patients who underwent MP for benign or low-grade malignant tumor of the pancreas between 1991 and 2006 at the Department of Surgery II, Nagoya University Graduate School of Medicine, were identified.
  • CONCLUSION: Middle pancreatectomy is a reasonable technique that is indicated for selected patients with benign or low malignant tumors in the neck and body of the pancreas.

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  • [Copyright] Copyright (c) 2010 Mosby, Inc. All rights reserved.
  • [CommentIn] Surgery. 2010 Jun;147(6):895 [20494216.001]
  • (PMID = 19682717.001).
  • [ISSN] 1532-7361
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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49. DiNorcia J, Schrope BA, Lee MK, Reavey PL, Rosen SJ, Lee JA, Chabot JA, Allendorf JD: Laparoscopic distal pancreatectomy offers shorter hospital stays with fewer complications. J Gastrointest Surg; 2010 Nov;14(11):1804-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Laparoscopic distal pancreatectomy (LDP) is increasingly performed for lesions of the body and tail of the pancreas.
  • LDP had lower blood loss (150 vs. 900 mL, p < 0.01), smaller tumor size (2.5 vs. 3.6 cm, p < 0.01), and shorter length of resected pancreas (7.7 vs. 10.0 cm, p < 0.01).
  • CONCLUSIONS: LDP can be performed safely and effectively in patients with benign or low-grade malignant neoplasms of the distal pancreas.

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  • (PMID = 20589446.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / T32 HL007854-14; United States / NHLBI NIH HHS / HL / T32 HL 007854 14; None / None / / T32 HL007854-13; United States / NHLBI NIH HHS / HL / T32 HL007854-13; None / None / / T32 HL007854-14; United States / NCRR NIH HHS / RR / L30 RR030243-01; United States / NHLBI NIH HHS / HL / T32 HL007854; United States / NCRR NIH HHS / RR / RR030243-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS284181; NLM/ PMC3081877
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50. Zhou J, Dong M, Kong F, Li Y, Tian Y: Central pancreatectomy for benign tumors of the neck and body of the pancreas: report of eight cases. J Surg Oncol; 2009 Sep 1;100(3):273-6
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  • [Title] Central pancreatectomy for benign tumors of the neck and body of the pancreas: report of eight cases.
  • BACKGROUND: To discuss the advantage of central pancreatectomy in the patients with benign tumors of the neck and body of the pancreas.
  • The operation is carried out by exposition of the pancreatic neck and body involved by the lesion.
  • RESULTS: Central pancreatectomy was done in eight patients including five mucinous cystadenomas, one serious cystadenoma, one insulinoma and one nonfunctional islet cell tumor.
  • CONCLUSION: Central pancreatectomy is a safe technique for benign tumors of the pancreatic neck and body, especially when the enucleation is very difficult.

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  • (PMID = 19267362.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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51. Iacono C, Bortolasi L, Facci E, Nifosì F, Pachera S, Ruzzenente A, Guglielmi A: The Dagradi-Serio-Iacono operation central pancreatectomy. J Gastrointest Surg; 2007 Mar;11(3):364-76
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Central pancreatectomy (CP) is a segmental pancreatic resection indicated to remove benign or low-grade malignant tumors of the isthmus and proximal part of the body of the pancreas.
  • Subsequently, the pancreatic portion harboring the tumor is isolated at its superior margin from the splenic artery after the pancreas is transacted.
  • Central pancreatectomy is a safe technique for benign or low malignant tumors of the pancreatic neck that allows curing the tumor with evident functional results without increasing the risk for the patient.

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  • (PMID = 17458612.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. Iso Y, Tagaya N, Kita J, Sawada T, Kubota K: Xanthogranulomatous lesion of the pancreas mimicking pancreatic cancer. Med Sci Monit; 2008 Nov;14(11):CS130-3
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  • [Title] Xanthogranulomatous lesion of the pancreas mimicking pancreatic cancer.
  • It is commonly accepted that Xanthogranulomatous lesion of the pancreas (XGP) is hardly distinguishable from pancreatic neoplasms.
  • CASE REPORT: An 82-year-old male was admitted to our hospital because of body weight loss.
  • Laboratory tests showed the presence of inflammation, and a Positron emission tomography (PET) revealed positive uptake in the pancreas head and tail, and spleen.
  • Intraductal ultrasonography (IOUS) showed a tumor located at the pancreas tail.
  • Under a preoperative diagnosis of intraductal papillary mucinous carcinoma (IPMC) at the pancreas tail with metastasis to the spleen, distal pancreatectomy and splenectomy were performed.
  • Although XGP is a benign condition, most cases are treated by surgery same as our case.

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  • (PMID = 18971878.001).
  • [ISSN] 1643-3750
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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53. Goh BK, Ooi LL, Kumarasinghe MP, Tan YM, Cheow PC, Chow PK, Chung YF, Wong WK: Clinicopathological features of patients with concomitant intraductal papillary mucinous neoplasm of the pancreas and pancreatic endocrine neoplasm. Pancreatology; 2006;6(6):520-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathological features of patients with concomitant intraductal papillary mucinous neoplasm of the pancreas and pancreatic endocrine neoplasm.
  • BACKGROUND/AIMS: The occurrence of concomitant pancreatic endocrine neoplasm (PEN) and intraductal papillary neoplasm (IPMN) of the pancreas has rarely been reported.
  • The median size of the endocrine neoplasms was 14 mm (range 2-30) and they occurred in the head (n = 3), body (n = 2) and tail (n = 5).
  • Seven of the PENs were classified as benign, 2 were potentially malignant, and 1 was frankly malignant with lymph node involvement.
  • The IPMNs were found in the tail (n = 4), head (n = 3), head and body (n = 1), body (n = 1) and the entire pancreas (n = 1).
  • Five of these neoplasms were benign, 2 were borderline and 3 were malignant (1 carcinoma in situ).
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. Chromogranins / metabolism. Female. Humans. Male. Middle Aged. Synaptophysin / metabolism. Tomography, X-Ray Computed. Treatment Outcome

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  • [Copyright] Copyright 2006 S. Karger AG, Basel and IAP.
  • (PMID = 17124434.001).
  • [ISSN] 1424-3903
  • [Journal-full-title] Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
  • [ISO-abbreviation] Pancreatology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromogranins; 0 / Synaptophysin
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54. Qu H, Wang CF, Zhao P, Shan Y, Zhao DB: [Local resection of pancreatic neoplasms: clinical analysis of 17 cases]. Zhonghua Yi Xue Za Zhi; 2008 May 27;88(20):1405-7
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  • RESULTS: Of the 17 tumors, 9 were located in the head, 7 located in the body, and 1 located in the tail of pancreas.
  • Pathological examination confirmed 8 tumors as nonfunctioning insulinoma, 5 as solid pseudopapillary tumor, 1 as neurilemmoma, 1 as cyst, 1 as gastrointestinal stroma tumor, and 1 as low-graded malignant tumor.
  • CONCLUSION: Capable pf preserving endocrine and exocrine functions, local resection is a feasible method for benign or low-graded malignant pancreatic neoplasms, however, with a high rate of pancreatic leakage.

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  • (PMID = 18953880.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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55. Hisa T, Ohkubo H, Shiozawa S, Ishigame H, Takamatsu M, Furutake M, Nobukawa B, Suda K: Growth process of small pancreatic carcinoma: a case report with imaging observation for 22 months. World J Gastroenterol; 2008 Mar 28;14(12):1958-60
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  • This report describes serial observations of the growth process of a small invasive ductal carcinoma (IDC) of the pancreas from imaging studies.
  • Histopathological studies showed IDC with macroscopic retention cysts proximal to an intraductal papillary-mucinous adenoma with mild atypia of the branch duct type in the pancreatic body, with no relation between the two lesions.
  • We misinterpreted the low-echoic mass as a benign intraductal mucinous-papillary neoplasm (IPMN) based on findings of other imaging studies, and the patient was followed-up.
  • The tumor volume doubling time was 252 d.

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  • (PMID = 18350642.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2700420
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56. Pauser U, da Silva MT, Placke J, Klimstra DS, Klöppel G: Cellular hamartoma resembling gastrointestinal stromal tumor: a solid tumor of the pancreas expressing c-kit (CD117). Mod Pathol; 2005 Sep;18(9):1211-6
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  • [Title] Cellular hamartoma resembling gastrointestinal stromal tumor: a solid tumor of the pancreas expressing c-kit (CD117).
  • Solid tumors of the pancreas are usually neoplastic.
  • We report on two adult patients, each with a solid tumor of the pancreas that presented with an unusual histology and seemed to follow a benign course.
  • The tumors, one located in the body and one in the tail, were well demarcated and composed of irregularly arranged but well-differentiated acini and small intralobular and interlobular ducts embedded in predominantly hypocellular fibrotic tissue that contained fascicles of cytologically bland spindle cells.
  • We propose to designate the tumors as 'cellular hamartoma resembling gastrointestinal stromal tumor.

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  • (PMID = 15803185.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Stem Cell Factor
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57. Giger U, Michel JM, Wiesli P, Schmid C, Krähenbühl L: Laparoscopic surgery for benign lesions of the pancreas. J Laparoendosc Adv Surg Tech A; 2006 Oct;16(5):452-7
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  • [Title] Laparoscopic surgery for benign lesions of the pancreas.
  • Conversion to open surgery was necessary in 6 patients because of: closeness of the lesion to the portal/mesenteric vein (n = 3), inadequate intraoperative tumor localization (n = 2), or stapler device dysfunction (n = 1).
  • CONCLUSION: Laparoscopic enucleation or distal pancreatectomy with spleen preservation for benign lesions located in the body or tail of the pancreas can be performed safely, with all the potential benefits of minimally invasive surgery.
  • Preoperative tumor localization is of utmost importance to limit pancreatic mobilization and to avoid blind pancreatic resection and conversion to open surgery.

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  • (PMID = 17004867.001).
  • [ISSN] 1557-9034
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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58. Liang H, Wang XN, Wang BG, Pan Y, Ding XW, Hao XS: [Management of nonfunctioning islet cell tumors of the pancreas]. Zhonghua Zhong Liu Za Zhi; 2007 Jun;29(6):457-60
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  • [Title] [Management of nonfunctioning islet cell tumors of the pancreas].
  • OBJECTIVE: To analyze the clinical and pathological features in order to investigate appropriate way of diagnosis and treatment for non-functional islet cell tumors of the pancreas (NFICT).
  • Twenty-eight patients were diagnosed as having non-functional islet cell carcinomas of the pancreas (NFICC) and 15 patients benign islet cell tumors.
  • Preoperatively, all of those were found to have a mass in their pancrease by ultrasonic and computed tomography examination, with 21 in the head, 10 in the body and 6 in the tail of the pancreas.
  • Multicemtric tumor were found in one patient.
  • The resectability and curative resection rate in 28 patients with nonfunctioning islet cell carcinomas of the pancreas was 78.6% and 60.7%, respectively.
  • None of the 15 patients with benign nonfunctioning islet cell tumor of the pancreas died of this disease.
  • While the overall cumulative 5- and 10-year survival rate in 28 patients with non-functional islet cell carcinomas of the pancreas was only 58.1% and 29.0%, respectively.
  • CONCLUSION: Nonfunctioning islet cell tumor of the pancreas is frequently found in young female.

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  • (PMID = 17974283.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 50SG953SK6 / Mitomycin; 80168379AG / Doxorubicin; U3P01618RT / Fluorouracil; FAM protocol
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59. Dinter DJ, Aramin N, Weiss C, Singer C, Weisser G, Schoenberg SO, Post S, Niedergethmann M: Prediction of anastomotic leakage after pancreatic head resections by dynamic magnetic resonance imaging (dMRI). J Gastrointest Surg; 2009 Apr;13(4):735-44
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  • Signal intensity (SI) measurements (aorta, body of the pancreas, muscle tissue) were performed in the axial T1-weighted sequences before and after 25 and 60 s after i.v. application of gadolinium-diethylenetriaminepentaacetic acid.
  • SI(ratio)s were classified in two groups: rapid increase (SI(ratio) >or= 1.1, early arterial value > portal-venous value, "soft" pancreas) and delayed increase (SI(ratio) <1.1, "firm" or "hard" pancreas).
  • RESULTS: Leakage of the pancreaticojejunostomy occurred more frequently (12/37 vs. two of 35, 32% vs. 6%, p = 0.006) in patients with a rapid increase and an SI(ratio) >or= 1.1 ("soft" pancreas, n = 37) compared to those with delayed perfusion (SI(ratio) <1.1, "hard" pancreas, n = 35).
  • Patients with a rapid increase had significantly better preoperative American Society of Anesthesiologists staging, lower carbohydrate antigen 19-9 values, and smaller tumor sizes.
  • Most of them had not only benign tumors but also longer postoperative hospital stay, in comparison to patients with delayed perfusion (SI(ratio) <1.1).
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anastomosis, Surgical. CA-19-9 Antigen / blood. Female. Humans. Male. Middle Aged. Multivariate Analysis. Pancreas / pathology. Predictive Value of Tests. Retrospective Studies. Risk Factors. Suture Techniques

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  • (PMID = 19057965.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CA-19-9 Antigen
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60. Ait-Ali A, Sall I, El-Kaoui H, Bouchentouf SM, El-Hjouji A, Rouibaa F, Benkirane A, Bounaim A, Zentar A, Sair K: Medial pancreatectomy for a neuroendocrine tumor invading the splenic artery and vein. JOP; 2010;11(1):75-7
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  • [Title] Medial pancreatectomy for a neuroendocrine tumor invading the splenic artery and vein.
  • A medial or central pancreatectomy is an alternative technique for benign or low-grade malignant neoplasms located to the left of the gastroduodenal artery and close to the splenomesenteric confluence.
  • A computed tomography scan showed a 4 cm heterogeneous lesion within the pancreatic body.
  • This tumor invaded the splenic artery and vein.
  • CONCLUSION: We believe that a medial or central pancreatectomy may be a safe procedure where there is involvement of the large splenic vessels by a low grade malignant pancreatic tumor and that a systematic splenectomy is not justified.
  • [MeSH-minor] Adult. Female. Humans. Neoplasm Invasiveness. Splenic Neoplasms / prevention & control. Splenic Neoplasms / secondary

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  • (PMID = 20065560.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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61. Matsukawa H, Takakura N, Shiozaki S, Aoki H: [Case of lymphoepithelial cyst of the pancreas]. Nihon Shokakibyo Gakkai Zasshi; 2008 Jun;105(6):854-9
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  • [Title] [Case of lymphoepithelial cyst of the pancreas].
  • We recently experienced a case of lymphoepithelial cyst of the pancreas, which is a rare benign pancreatic cystic tumor.
  • A 59-year-old-man was pointed out as having a pancreatic tumor based on abdominal ultrasonography findings obtained during a medical check-up.
  • Thereafter, abdominal ultrasonography, CT, and MRI studies revealed the presence of a multi-cystic tumor in the pancreas body to tail measuring 45 mm in size which had no infiltrating tendency.
  • The operative findings showed a yellowish-white colored cystic tumor covered with a thin capsule, which could be easily extirpated from the pancreas.
  • The dissected tumor, which contained a curd-like material and a condensed milky liquid, was diagnosed to be a lymphoepithelial cyst of the pancreas based on the pathological findings.
  • Similar reports of lymphoepithelial cysts arising in the pancreas have recently been increasing.
  • [MeSH-minor] Diagnosis, Differential. Diagnostic Imaging. Epithelium / pathology. Humans. Lymphoid Tissue / pathology. Male. Middle Aged. Pancreas / pathology

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  • (PMID = 18525193.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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