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1. Adhikari RC, Tuladhar A, Shrestha S, Sharma SK: Deep-seated thoracic and abdominal lesions: usefulness of ultrasound guided fine needle aspiration cytology, a 3 year experience. Nepal Med Coll J; 2010 Mar;12(1):20-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Deep-seated thoracic and abdominal lesions: usefulness of ultrasound guided fine needle aspiration cytology, a 3 year experience.
  • The aim of this study was to evaluate the overall utility of ultrasonographic guided FNAC in the diagnosis of abdominal and thoracic lesions.
  • In 264 cases (82.5%), FNAC was diagnostic with commonest diagnosis being malignant neoplasm (70.0%).
  • In liver, Metastatic adenocarcinoma is the commonest tumor, while in lung; the commonest lesion is non-small cell carcinoma.
  • Benign neoplasm (3.1%) and non neoplastic lesion (9.4%) were also diagnosed by FNAC.
  • USG guided FNAC, in conjunction with clinico-radiological parameters are accurate and safe in diagnosing deep-seated mass lesions in the thorax and abdomen.

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  • (PMID = 20677604.001).
  • [Journal-full-title] Nepal Medical College journal : NMCJ
  • [ISO-abbreviation] Nepal Med Coll J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nepal
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2. Gaissert HA, Mark EJ: Tracheobronchial gland tumors. Cancer Control; 2006 Oct;13(4):286-94
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  • Bronchial gland tumors demonstrate oncologic diversity and include benign, low-grade, and high-grade malignant tumors.
  • METHODS: We reviewed the present knowledge of bronchial gland tumors of the trachea, carina, and bronchi, including the epidemiology, presentation, evaluation, tumor types, and treatment options.
  • RESULTS: The malignant bronchial gland tumors, adenoid cystic carcinoma and mucoepidermoid carcinoma, are far more common than benign mucinous cystadenoma or pleomorphic adenoma.
  • Complete resection of localized tumors has excellent long-term results in symptomatic benign tumors.
  • [MeSH-minor] Clinical Trials as Topic. Humans. Neoplasm Staging. Salivary Gland Neoplasms / pathology. Salivary Gland Neoplasms / therapy. Thoracic Surgical Procedures. United States / epidemiology

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  • (PMID = 17075566.001).
  • [ISSN] 1073-2748
  • [Journal-full-title] Cancer control : journal of the Moffitt Cancer Center
  • [ISO-abbreviation] Cancer Control
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 49
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3. Cerfolio RJ, Bryant AS, Ojha B: Restaging patients with N2 (stage IIIa) non-small cell lung cancer after neoadjuvant chemoradiotherapy: a prospective study. J Thorac Cardiovasc Surg; 2006 Jun;131(6):1229-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • When the maximum standardized uptake value of the primary tumor is decreased by 75% or more, it is highly likely (likelihood ratio, +LR, 6.1) the patient is a complete responder; when it decreased by 55% or more, it is highly likely (+LR, 9.1) the patient is a partial responder.
  • When the maximum standardized uptake value of the N2 node initially involved with metastatic cancer is decreased by more than 50%, it is highly likely (+LR, 7.9) the node is now benign.
  • [MeSH-minor] Adult. Aged. Algorithms. Chemotherapy, Adjuvant. Female. Humans. Male. Middle Aged. Neoplasm Staging. Positron-Emission Tomography. Prospective Studies. Radiotherapy, Adjuvant. Reproducibility of Results. Tomography, X-Ray Computed

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  • [CommentIn] J Thorac Cardiovasc Surg. 2007 Jan;133(1):275-6; author reply 276-7 [17198837.001]
  • [CommentIn] J Thorac Cardiovasc Surg. 2006 Jun;131(6):1227-8 [16733149.001]
  • [ErratumIn] J Thorac Cardiovasc Surg. 2006 Sep;132(3):565-7
  • (PMID = 16733150.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] United States
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4. Kushibe K, Kawaguchi T, Nishimoto Y, Takahama M, Tojo T, Taniguchi S: Operative indications for lung cancer with satellite lesions. Asian Cardiovasc Thorac Ann; 2006 Aug;14(4):316-20
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  • In deciding the surgical treatment for lung cancer, it is important to differentiate between a small satellite lesion that is probably benign, a pulmonary metastatic lesion, or a double cancer.
  • The final diagnosis of the satellite lesions was malignant in 13 and benign in 30.
  • Two patients with stage IIb and IIIb disease on clinical staging of the main tumor had pulmonary metastases.
  • Patients with clinical stage I disease had a higher probability that the small lesions were benign or double cancers than those with advanced disease beyond clinical stage I.
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 16868106.001).
  • [ISSN] 1816-5370
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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5. Rena O, Papalia E, Ruffini E, Filosso PL, Oliaro A, Maggi G, Casadio C: The role of surgery in the management of solitary pulmonary nodule in breast cancer patients. Eur J Surg Oncol; 2007 Jun;33(5):546-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histology of SPN was primary lung cancer in 38 patients, pulmonary metastasis of breast cancer in 27, and benign condition in 14.
  • [MeSH-major] Breast Neoplasms / pathology. Lung Neoplasms / surgery. Neoplasms, Multiple Primary / surgery. Solitary Pulmonary Nodule / surgery. Thoracic Surgery, Video-Assisted
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Middle Aged. Neoplasm Metastasis. Retrospective Studies. Survival Analysis

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  • (PMID = 17267164.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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6. Folk GS, Williams SB, Foss RB, Fanburg-Smith JC: Oral and maxillofacial sclerosing epithelioid fibrosarcoma: report of five cases. Head Neck Pathol; 2007 Sep;1(1):13-20
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  • The OMF Pathology Department Registry was searched for cases coded from 1990 to the present as "SEF," "fibrosarcoma not otherwise specified" or "neoplasm of uncertain histiogenesis."
  • Tumor location included the infra-temporal fossa, buccal mucosa (recurrence extending into bone), anterior mandible (intraosseous primary, focally extending into soft tissue), and left parotid and submandibular gland (with metaplastic bone) regions.
  • Tumor sizes ranged from 1.0 to 5.7 cm, median 3.5 cm.
  • The spindled to primarily epithelioid tumor cells formed moderately cellular sheets and cords of irregularly contoured medium to large, round to oval, occasionally overlapping nuclei, indistinct nucleoli, wispy eosinophilic (retracting) cytoplasm, and distinctive cytoplasmic borders, embedded in osteoid-like stroma.
  • Immunohistochemically, the tumor cells were positive for vimentin, 1 case focally for CD34, whereas all cases were negative for S100 protein, keratins, EMA, desmin, and SMA.
  • Metastatic disease was present in 2 cases, to chest wall and lumbar/thoracic spine at 12 and 21 months, respectively.
  • The differential diagnosis for these tumors in this site includes sclerosing carcinoma, Ewing/PNET, osteosarcoma, osteoblastoma, and benign and malignant myoepithelial salivary gland tumors.
  • The collagen, focal spindle cell features, HPC-like vasculature, and weak focal CD34 reactivity in one case might have raised a possible relationship between OMFRSEF and low grade malignant solitary fibrous tumor, but the intraosseous propensity, epithelioid features and relative lack of CD34 make this a distinctive entity.
  • [MeSH-minor] Adult. Apoptosis. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Leiomyoma / diagnosis. Male. Middle Aged. Sclerosis. Solitary Fibrous Tumors / diagnosis. Young Adult

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  • [ErratumIn] Head Neck Pathol. 2013 Mar;7(1):103
  • (PMID = 20614275.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807507
  • [Keywords] NOTNLM ; Maxillofacial / Oral / Sarcoma / Sclerosing epithelioid fibrosarcoma
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7. Barbanera A, Nina P, Serchi E, Ascanio F: Aggressive recurrence of intra-extradural cervico-thoracic meningothelial meningioma. Acta Neurochir (Wien); 2007 Jan;149(1):83-6; discussion 86
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  • [Title] Aggressive recurrence of intra-extradural cervico-thoracic meningothelial meningioma.
  • Following subtotal removal, the tumour was histologically classified as meningothelial meningioma and no radiotherapy was recommended.
  • The neuroradiological workup demonstrated that the lesion was stable one year after the operation but, a few months later a tumour recurrence with huge bone destruction was detected.
  • The tumour was totally resected and a circumferential stabilization was performed.
  • The authors discuss the extremely malignant behaviour of a tumour classified as benign.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningioma / pathology. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Cervical Vertebrae. Fatal Outcome. Female. Humans. Middle Aged. Neoplasm Invasiveness. Thoracic Vertebrae

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  • (PMID = 17171297.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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8. Lee JW, Kim BS, Lee DS, Chung JK, Lee MC, Kim S, Kang WJ: 18F-FDG PET/CT in mediastinal lymph node staging of non-small-cell lung cancer in a tuberculosis-endemic country: consideration of lymph node calcification and distribution pattern to improve specificity. Eur J Nucl Med Mol Imaging; 2009 Nov;36(11):1794-802
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Between March 2004 and February 2006, all patients with NSCLC underwent FDG PET/CT and contrast-enhanced thoracic CT, and subsequent surgical resection.
  • After lymph nodes with calcification and bilateral hilar distribution were considered benign, sensitivity and specificity of PET/CT were 75% and 89% on a per-patient basis and 66% and 96% on a per-node station basis.
  • [MeSH-minor] Contrast Media. Endemic Diseases. False Positive Reactions. Female. Humans. Male. Middle Aged. Neoplasm Staging. Positron-Emission Tomography. Radiography, Thoracic. Sensitivity and Specificity. Tomography, X-Ray Computed


9. Hoffmann K, Kerner C, Wilfert W, Mueller M, Thiery J, Hauss J, Witzigmann H: Detection of disseminated pancreatic cells by amplification of cytokeratin-19 with quantitative RT-PCR in blood, bone marrow and peritoneal lavage of pancreatic carcinoma patients. World J Gastroenterol; 2007 Jan 14;13(2):257-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIM: To evaluate the diagnostic potential of cytokeratin-19 (CK-19) mRNA for the detection of disseminated tumor cells in blood, bone marrow and peritoneal lavage in patients with ductal adenocarcinoma of the pancreas.
  • METHODS: Sixty-eight patients with pancreatic cancer (n = 37), chronic pancreatitis (n = 16), and non-pancreatic benign surgical diseases (n = 15, control group) were included in the study.
  • Preoperative bone marrow aspirates and peritoneal lavage taken before mobilization of the tumor were analyzed.
  • All samples were evaluated for disseminated tumor cells by CK-19-specific nested-PCR and quantitative fluorogenic RT-PCR.
  • In 15 (40%) of the patients with pancreatic cancer, disseminated tumor cells were detected in venous blood and bone marrow and/or peritoneal lavage.
  • In the peritoneal lavage, the detection rates were correlated with the tumor size and the tumor differentiation.
  • Pancreatic cancer patients showed significantly increased detection rates of disseminated tumor cells in blood and peritoneal lavage compared to the controls and the patients with chronic pancreatitis.
  • CONCLUSION: Disseminated tumor cells can be detected in patients with pancreatic ductal adenocarcinoma by CK-19 fluorogenic RT-PCR.
  • In peritoneal lavage, detection rate is correlated with tumor stage and differentiation.
  • In the clinical use, CK-19 is suitable for the distinction between malignant and benign pancreatic disease in combination with other tumor-specific markers.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Pancreatic Ductal / diagnosis. Keratin-19 / genetics. Neoplastic Cells, Circulating / chemistry. Pancreatic Neoplasms / diagnosis. RNA, Neoplasm / analysis. Reverse Transcriptase Polymerase Chain Reaction / methods

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  • (PMID = 17226905.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Keratin-19; 0 / RNA, Messenger; 0 / RNA, Neoplasm
  • [Other-IDs] NLM/ PMC4065954
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10. Dunham CP, Curry B, Hamilton M: Malignant transformation of an intraaxial-supratentorial neurenteric cyst - case report and review of the literature. Clin Neuropathol; 2009 Nov-Dec;28(6):460-6
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  • Neurenteric cysts are "rare benign mass forming developmental abnormalities" that usually affect young adults.
  • Anatomically, neurenteric cysts most frequently arise in an intradural-extraaxial location anterior to the cervical-thoracic spinal cord.
  • Areas of direct transition between typical benign neurenteric cyst epithelia and malignant epithelia (i.e., carcinoma in situ), highlighted by an abrupt change in the Ki-67 proliferative index, were identified, and supported the primary nature of this brain neoplasm.

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  • (PMID = 19919821.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 20
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11. Komatsu T, Fukuse T, Wada H, Sakurai T: Pulmonary sclerosing hemangioma with pulmonary metastasis. Thorac Cardiovasc Surg; 2006 Aug;54(5):348-9
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  • Pulmonary sclerosing hemangioma is a relatively rare neoplasm.
  • Although it is thought to be benign, cases with lymph node metastasis or multiple pulmonary involvement have been reported in clinical settings.
  • [MeSH-minor] Aged. Female. Humans. Lymphatic Metastasis. Thoracic Surgery, Video-Assisted

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  • (PMID = 16902885.001).
  • [ISSN] 0171-6425
  • [Journal-full-title] The Thoracic and cardiovascular surgeon
  • [ISO-abbreviation] Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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12. Dim DC, Nugent SL, Peng HQ: Ganglioneuroma presenting as a paraesophageal mass lesion diagnosed by endoscopic ultrasound-guided fine needle aspiration cytology: a case report. Acta Cytol; 2010 May-Jun;54(3):321-4
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  • Ganglioneuroma is a benign, rare, soft tissue neoplasm arising from sympathetic ganglion cells, and complete surgical resection is considered to be curative.
  • Upper endosonography identified a 40x17-mm mass extrinsic to the thoracic esophagus.
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Diagnosis, Differential. Endosonography. Esophagus / pathology. Humans. Male. S100 Proteins / metabolism

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  • (PMID = 20518419.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins
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13. Levy-Faber D, Kremer R, Orlovsky M, Barak M, Best LA: [Surgical management of esophageal pathology: 6 years of experience in a single surgical department]. Harefuah; 2009 Mar;148(3):149-52, 212
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Whether benign or malignant, these diseases interfere with food swallowing.
  • RESULTS: During the study period, 186 patients were operated for esophageal pathology, 154 (83%) had malignant disease and 32 (17%) had benign disease.
  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Carcinoma, Signet Ring Cell / mortality. Carcinoma, Signet Ring Cell / pathology. Carcinoma, Signet Ring Cell / surgery. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Female. Humans. Male. Neoplasm Staging. Postoperative Complications / epidemiology. Postoperative Complications / pathology. Retrospective Studies. Survival Analysis. Survivors

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  • (PMID = 19485270.001).
  • [ISSN] 0017-7768
  • [Journal-full-title] Harefuah
  • [ISO-abbreviation] Harefuah
  • [Language] heb
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Israel
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14. Yang W, Yu J: Immunologic function of dendritic cells in esophageal cancer. Dig Dis Sci; 2008 Jul;53(7):1739-46
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  • This review concerns the immunology of dendritic cells in esophageal cancer; it describes the expression of DCs in the normal esophageal tissues and benign disease of esophagus, relations between the DCs and cancer development in esophageal cancer, and the DC-based approach to establish treatment for esophageal cancer.
  • [MeSH-minor] Antigens, Neoplasm / immunology. Esophagus / cytology. Humans

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  • (PMID = 18080193.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm
  • [Number-of-references] 49
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15. GU J, WANG X, ZHAO H, ZHU S, WEN Y, XU H, LI L, CHEN J, ZHOU Q: [Diagnosis value of the detection of CYFRA21-1 in non-small cell lung cancer]. Zhongguo Fei Ai Za Zhi; 2010 Dec;13(12):1118-21
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  • BACKGROUND AND OBJECTIVE: cytokeratin-19 fragment (CYFRA21-1) is a soluble protein in serum, and may be a useful circulating tumor marker.
  • METHODS: the levels of peripheral blood CYFRA21-1 were detected in 107 patients with NSCLC and 51 patients with benign pulmonary diseases by enzyme linked immunosorbent assay, and ROC curve was used to analyse the results.
  • RESULTS: singificant difference of peripheral blood CYFRA21-1 levels was detected between the NSCLC group and benign pulmonary disease group (Chi-Square=47.343, P < 0.001).
  • CONCLUSIONS: as a tumor marker CYFRA21-1 has relative high sensitivity and specificity for the diagnosis of NSCLC.
  • [MeSH-major] Antigens, Neoplasm / blood. Carcinoma, Non-Small-Cell Lung / blood. Carcinoma, Non-Small-Cell Lung / diagnosis. Keratin-19 / blood

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  • (PMID = 21159246.001).
  • [ISSN] 1999-6187
  • [Journal-full-title] Zhongguo fei ai za zhi = Chinese journal of lung cancer
  • [ISO-abbreviation] Zhongguo Fei Ai Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Keratin-19; 0 / antigen CYFRA21.1
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16. Shibata H, Nomori H, Uno K, Iyama K, Tomiyoshi K, Nakashima R, Sakaguchi K, Goya T, Takanami I, Koizumi K, Suzuki T, Kaji M, Horio H: 11C-acetate for positron emission tomography imaging of clinical stage IA lung adenocarcinoma: comparison with 18F-fluorodeoxyglucose for imaging and evaluation of tumor aggressiveness. Ann Nucl Med; 2009 Sep;23(7):609-16
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  • [Title] 11C-acetate for positron emission tomography imaging of clinical stage IA lung adenocarcinoma: comparison with 18F-fluorodeoxyglucose for imaging and evaluation of tumor aggressiveness.
  • BACKGROUND: To determine the usefulness of positron emission tomography (PET) with (11)C-acetate (AC) for imaging lung adenocarcinoma and evaluating its tumor aggressiveness, AC- and (18)F-fluorodeoxyglucose (FDG)-PET were compared.
  • METHODS: One hundred and sixty-nine adenocarcinomas with clinical stage IA and 53 benign nodules were examined by both AC- and FDG-PET before surgery.
  • The sensitivity and specificity for discriminating benign/adenocarcinoma were compared between AC- and FDG-PET.
  • The AC and FDG uptakes were examined to determine the relationship with tumor aggressiveness, i.e., pathological tumor stage, lymphatic, vascular, or pleural involvement, and proliferative activity determined by Ki-67 staining score.
  • While FDG uptakes were significantly higher in tumors with pathological advanced stages or those with lymphatic, vascular and/or pleural involvements than in tumors with pathological stage IA or those without these tumor involvements (p = 0.04 to p < 0.001), AC uptake did not show significant differences between the respective sub-groups except according to the tumor stage.
  • CONCLUSIONS: While AC-PET can image BAC and W/D adenocarcinoma with a higher sensitivity than FDG-PET, it cannot evaluate tumor aggressiveness of clinical stage IA lung adenocarcinoma as well as FDG-PET.
  • [MeSH-minor] Humans. Neoplasm Staging. Positron-Emission Tomography. ROC Curve. Tomography, X-Ray Computed. Tumor Burden

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  • (PMID = 19562438.001).
  • [ISSN] 1864-6433
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Acetates; 0 / carbon-11 acetate; 0Z5B2CJX4D / Fluorodeoxyglucose F18; 7440-44-0 / Carbon
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17. Mizobuchi T, Masahiro N, Iwai N, Kohno H, Okada N, Nakada S: Clear cell tumor of the lung: surgical and immunohistochemical findings. Gen Thorac Cardiovasc Surg; 2010 May;58(5):243-7
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  • [Title] Clear cell tumor of the lung: surgical and immunohistochemical findings.
  • We encountered a clear cell tumor of the lung (CCTL) that was located peripherally, adjacent to the visceral pleura.
  • The tumor could be directly observed during surgery.
  • Wedge resection was performed by video-assisted thoracic surgery.
  • The in vivo color of the tumor was red, suddenly changing to white after the tumor was clamped.
  • Immunohistochemistry revealed tumor cells positive for vimentin and melanocytic markers (HMB-45 and melan-A) and negative for epithelial membrane antigen and cytokeratin.
  • With the absence of clinical findings in both kidneys, the tumor was diagnosed as a benign CCTL.
  • [MeSH-major] Biomarkers, Tumor / analysis. Immunohistochemistry. Lung Neoplasms / chemistry. Lung Neoplasms / surgery. Perivascular Epithelioid Cell Neoplasms / chemistry. Perivascular Epithelioid Cell Neoplasms / surgery. Thoracic Surgery, Video-Assisted
  • [MeSH-minor] Aged. Antigens, Neoplasm / analysis. Female. Humans. Incidental Findings. MART-1 Antigen. Melanoma-Specific Antigens. Neoplasm Proteins / analysis. Tomography, X-Ray Computed. Treatment Outcome. Vimentin / analysis

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  • (PMID = 20449716.001).
  • [ISSN] 1863-6713
  • [Journal-full-title] General thoracic and cardiovascular surgery
  • [ISO-abbreviation] Gen Thorac Cardiovasc Surg
  • [Language] eng
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18. Li Y, Yang Z: [Research development of MDCT perfusion imaging on solitary pulmonary nodules]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi; 2008 Oct;25(5):1222-5
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  • Differentiation between benign and malignant solitary pulmonary nodules remains significant and a challenge to thoracic radiologists.
  • Recently, MDCT perfusion imaging has sparked new interest in the noninvasive assessment of pulmonary neoplasm.

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  • (PMID = 19024481.001).
  • [ISSN] 1001-5515
  • [Journal-full-title] Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
  • [ISO-abbreviation] Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 18
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19. Rom WN, Goldberg JD, Addrizzo-Harris D, Watson HN, Khilkin M, Greenberg AK, Naidich DP, Crawford B, Eylers E, Liu D, Tan EM: Identification of an autoantibody panel to separate lung cancer from smokers and nonsmokers. BMC Cancer; 2010 May 26;10:234
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  • BACKGROUND: Sera from lung cancer patients contain autoantibodies that react with tumor associated antigens (TAAs) that reflect genetic over-expression, mutation, or other anomalies of cell cycle, growth, signaling, and metabolism pathways.
  • METHODS: We performed immunoassays to detect autoantibodies to ten tumor associated antigens (TAAs) selected on the basis of previous studies showing that they had preferential specificity for certain cancers.
  • Sera examined were from lung cancer patients (22); smokers with ground-glass opacities (GGOs) (46), benign solid nodules (55), or normal CTs (35); and normal non-smokers (36).

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  • (PMID = 20504322.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / T32 ES007267; United States / NCRR NIH HHS / RR / M01RR-00096; United States / NCI NIH HHS / CA / U01CA86137; United States / NCI NIH HHS / CA / U01 CA086137-11; United States / NCI NIH HHS / CA / CA086137-11; United States / NIEHS NIH HHS / ES / T32 ES007267-18; United States / NIEHS NIH HHS / ES / ES007267-18; United States / NCI NIH HHS / CA / CA 56956; United States / NCI NIH HHS / CA / U01 CA086137
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Autoantibodies
  • [Other-IDs] NLM/ PMC2885364
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20. Haresh KP, Prabhakar R, Rath GK, Sharma DN, Julka PK, Subramani V: Adenoid cystic carcinoma of the trachea treated with PET-CT based intensity modulated radiotherapy. J Thorac Oncol; 2008 Jul;3(7):793-5
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  • Primary tumors of the trachea are rare and are usually malignant in adults and benign in children.
  • Computed tomography scan of the thorax at our hospital showed a residual disease in the primary site, size of which was same as that in the preoperative scan.
  • [MeSH-minor] Fluorodeoxyglucose F18. Humans. Male. Middle Aged. Neoplasm, Residual / radiography. Neoplasm, Residual / radionuclide imaging. Neoplasm, Residual / radiotherapy. Radiography, Interventional. Radiopharmaceuticals

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  • (PMID = 18594327.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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21. Vilos GA, Hollett-Caines J, Abu-Rafea B, Allen HH, Inculet R, Kirk ME: Leiomyosarcoma diagnosed six years after laparoscopic electromyolysis. J Obstet Gynaecol Can; 2008 Jun;30(6):500-504
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  • BACKGROUND: Making a histologic diagnosis of leiomyosarcoma in the specimen from a hysterectomy performed for suspected benign fibroids is rare.
  • [MeSH-minor] Adult. Female. Humans. Hysterectomy. Laparoscopy. Lung Neoplasms / secondary. Lung Neoplasms / surgery. Myometrium / surgery. Neoplasm Metastasis. Treatment Outcome

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  • (PMID = 18611301.001).
  • [ISSN] 1701-2163
  • [Journal-full-title] Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
  • [ISO-abbreviation] J Obstet Gynaecol Can
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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22. Kang MW, Han JH, Yu JH, Kim YH, Na MH, Yu JH, Lim SP, Lee Y, Kim JH, Kang DY, Kim JO: Multiple central endobronchial chondroid hamartoma. Ann Thorac Surg; 2007 Feb;83(2):691-3
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  • Benign neoplasm of the lung is rare, and pulmonary hamartoma is the most common form of benign neoplasm of the lung.
  • Reports of multiple endobronchial chondroid hamartomas are rare in the literature, and the awareness of this form of benign disease is important in the differential diagnosis of pulmonary neoplasms.
  • [MeSH-minor] Bronchoscopy. Humans. Male. Middle Aged. Radiography, Thoracic. Tomography, X-Ray Computed

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  • (PMID = 17258021.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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23. Massion PP, Caprioli RM: Proteomic strategies for the characterization and the early detection of lung cancer. J Thorac Oncol; 2006 Nov;1(9):1027-39
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  • Biochemical techniques focused on changes in the proteome in benign and malignant conditions have been applied to the study of lung cancer.
  • Although relatively little information is currently available about the human lung proteome, the major goals of the analysis of lung cancer are to better understand tumor biology, to define early detection biomarkers and predictors of tumor behavior, and to identify potential new therapeutic targets.
  • [MeSH-major] Biomarkers, Tumor / blood. Early Diagnosis. Lung Neoplasms / diagnosis. Proteomics / methods
  • [MeSH-minor] Disease Progression. Electrophoresis, Gel, Two-Dimensional. Female. Humans. Male. Mass Spectrometry. Neoplasm Proteins / analysis. Neoplasm Staging. Predictive Value of Tests. Prognosis. Protein Array Analysis. Sensitivity and Specificity. Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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  • (PMID = 17409991.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA102353
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
  • [Number-of-references] 95
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24. Navarrete Isidoro O, Abad Fernández A, López Vime R, Jara Chinarro B, Juretschke Moragues MA: [Pulmonary metastasis of Basal cell carcinoma of the skin]. Arch Bronconeumol; 2005 Mar;41(3):169-71
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  • [Transliterated title] Metástasis pulmonares de un carcinoma basocelular cutáneo.
  • Basal cell carcinoma of the skin is a common neoplasm usually considered benign.
  • [MeSH-minor] Adult. Biopsy. Humans. Lung / pathology. Male. Radiography, Thoracic. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 15766469.001).
  • [ISSN] 0300-2896
  • [Journal-full-title] Archivos de bronconeumología
  • [ISO-abbreviation] Arch. Bronconeumol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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25. Santini M, Fiorello A, Mansi L, Rambaldi PF, Vicidomini G, Busiello L, Messina G, Nargi P: The role of technetium-99m hexakis-2-methoxyisobutyl isonitrile in the detection of neoplastic lung lesions. Eur J Cardiothorac Surg; 2009 Feb;35(2):325-31
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  • In addition, semiquantitative analysis was made by calculating tumor/contralateral normal lung ratio (T/N).
  • Nineteen patients had a benign disease.
  • The mean size+/-standard deviation of benign nodules was 3.3+/-1.71 cm (range 2-6 cm). (99m)Tc-MIBI SPECT delineated focal lesions with an increase in tracer accumulation in 55/60 malignant lesions; in 5/60 malignant lesions was negative.
  • In patients with neoplastic lesion, the mean T/N ratio value+/-standard deviation was 1.72+/-0.35 whereas in patients with benign lesions was 1.14+/-0.25.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Epidemiologic Methods. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Tomography, Emission-Computed, Single-Photon / methods. Tomography, X-Ray Computed

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  • (PMID = 18996706.001).
  • [ISSN] 1873-734X
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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26. Attene F, Scognamillo F, Xidas A, Serventi F, Trignano M: [The role of cervical mediastinoscopy and video assisted thoracoscopy in the diagnosis and staging of thoraco-mediastinal neoplastic diseases]. Ann Ital Chir; 2009 Jan-Feb;80(1):17-24
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  • DISCUSSION: In these ten years, thanks to adequate indication for mediastinoscopy and video assisted thoracoscopy, the use of thoracotomy for diagnosis and staging of pulmonary neoplastic diseases has been reduced: thus we avoided 80% of unnecessary thoracotomies in patients affected by not resectable lung cancer, metastases (treated by atypical thoracoscopic resection) or benign diseases.
  • CONCLUSION: The minimally invasive surgical exploration of mediastinum and thoracic cavity allows to obtain all necessary informations (in terms of histology and staging) to programme an adequate therapeutic protocol, reducing postoperative pain and hospital stay, in comparison to thoracotomy.
  • [MeSH-major] Lung Neoplasms / diagnosis. Mediastinal Neoplasms / diagnosis. Mediastinoscopy. Thoracic Surgery, Video-Assisted
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Lung Diseases / diagnosis. Male. Middle Aged. Neoplasm Staging. Pneumonectomy. Prognosis. Retrospective Studies. Solitary Pulmonary Nodule / diagnosis. Treatment Outcome

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  • (PMID = 19537118.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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27. Kim HK, Choi YS, Kim K, Shim YM, Jeong SY, Lee KS, Kwon OJ, Kim J: Management of ground-glass opacity lesions detected in patients with otherwise operable non-small cell lung cancer. J Thorac Oncol; 2009 Oct;4(10):1242-6
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  • INTRODUCTION: When pure ground-glass opacity (GGO) lesions are detected in patients with otherwise operable non-small cell lung cancer, it is controversial whether to resect them simultaneously with the primary tumor or not.
  • Four of the eight lesions that were simultaneously resected at surgery for the primary tumor turned out to be malignant.
  • We tried to predict whether a lesion is benign or malignant based on its size.
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / radiography. Adenocarcinoma / surgery. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Adenocarcinoma, Bronchiolo-Alveolar / radiography. Adenocarcinoma, Bronchiolo-Alveolar / surgery. Adult. Aged. Carcinoma, Adenosquamous / pathology. Carcinoma, Adenosquamous / radiography. Carcinoma, Adenosquamous / surgery. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / radiography. Carcinoma, Squamous Cell / surgery. Female. Humans. Male. Middle Aged. Neoplasm Staging. Radiography, Interventional. Retrospective Studies. Sensitivity and Specificity. Survival Rate. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19687762.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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28. Chella B, Nosotti M, Baisi A, Lattuada E, Mazzone A, Santambrogio L: Unusual presentation of a transparietal cavernous hemangioma of the esophagus. Dis Esophagus; 2005;18(5):349-54
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  • Hemangiomas are tumors of vascular origin and represent less than 3% of benign neoplasm of the esophagus.
  • In fact, on microscopic observation of the specimen, the neoplasm appeared to be a cavernous hemangioma of the esophageal submucosa with transparietal extension.

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  • (PMID = 16197539.001).
  • [ISSN] 1120-8694
  • [Journal-full-title] Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
  • [ISO-abbreviation] Dis. Esophagus
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Kesler KA, Wilson JL, Cosgrove JA, Brooks JA, Messiha A, Fineberg NS, Einhorn LH, Brown JW: Surgical salvage therapy for malignant intrathoracic metastases from nonseminomatous germ cell cancer of testicular origin: analysis of a single-institution experience. J Thorac Cardiovasc Surg; 2005 Aug;130(2):408-15
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  • BACKGROUND: Cisplatin-based chemotherapy followed by surgical extirpation of residual benign disease represents the usual sequence of curative therapy for metastatic nonseminomatous germ cell cancer of testicular origin.
  • Occasionally, residual disease is malignant in the form of either a persistent nonseminomatous germ cell cancer tumor or degeneration into non-germ cell cancer.
  • CONCLUSIONS: Salvage thoracic surgery to remove malignant metastases from nonseminomatous germ cell cancer tumors of testicular origin can result in long-term survival in select patients.
  • [MeSH-major] Lung Neoplasms / therapy. Mediastinal Neoplasms / therapy. Neoplasms, Germ Cell and Embryonal / therapy. Testicular Neoplasms / therapy. Thoracic Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents / therapeutic use. Cisplatin / therapeutic use. Combined Modality Therapy. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Survival Analysis. Treatment Outcome


30. Gagua PO, Macharashvili LI, Kuchava VO, Gzirishvili LM, Lomidze ZT: [Diagnosis and results of surgical treatment of rare giant intrathoracic tumors]. Khirurgiia (Mosk); 2005;(12):21-4
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  • The tumor located in the mediastinum in 8 patients, in the lungs -- in 6, in the chest wall with intrathoracic growth -- in 5 patients.
  • Radical surgery is the method of choice in surgical treatment of giant benign intrathoracic tumors.
  • [MeSH-major] Hemangiosarcoma / radiography. Hemangiosarcoma / surgery. Liposarcoma / radiography. Liposarcoma / surgery. Thoracic Neoplasms / radiography. Thoracic Neoplasms / surgery. Thoracic Surgical Procedures / methods
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Tomography, X-Ray Computed

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  • (PMID = 16353021.001).
  • [ISSN] 0023-1207
  • [Journal-full-title] Khirurgiia
  • [ISO-abbreviation] Khirurgiia (Mosk)
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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31. Altorki NK, Yankelevitz DF, Vazquez MF, Kramer A, Henschke CI: Bronchioloalveolar carcinoma in small pulmonary nodules: clinical relevance. Semin Thorac Cardiovasc Surg; 2005;17(2):123-7
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  • Although the majority of these nodules are benign in etiology, a subset will harbor bronchioloalveolar carcinoma.
  • [MeSH-minor] Diagnostic Errors. Humans. Neoplasm Staging. Prevalence. Tomography, X-Ray Computed

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  • (PMID = 16087079.001).
  • [ISSN] 1043-0679
  • [Journal-full-title] Seminars in thoracic and cardiovascular surgery
  • [ISO-abbreviation] Semin. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Carretta A, Bandiera A, Melloni G, Ciriaco P, Arrigoni G, Rizzo N, Negri G, Zannini P: Solitary fibrous tumors of the pleura: Immunohistochemical analysis and evaluation of prognostic factors after surgical treatment. J Surg Oncol; 2006 Jul 1;94(1):40-4
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  • Although surgery is the treatment of choice for SFTP, tumor recurrence may occur after complete resection, even in tumors with benign histological features.
  • Mean tumor size was 10 cm.
  • Histological features were benign in 16 patients and malignant in 2.
  • A higher incidence of tumor recurrence was observed when SFTP originated from the parietal pleura, had malignant histological features and a lower expression of progesterone receptors (P < 0.05).
  • [MeSH-major] Fibroma / pathology. Fibroma / surgery. Neoplasm Recurrence, Local / pathology. Pleural Neoplasms / pathology. Pleural Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Female. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis. Receptors, Estrogen / metabolism. Receptors, Progesterone / metabolism. Survival Rate. Thoracic Surgery, Video-Assisted. Thoracotomy

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16788942.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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33. Lardinois D, Weder W, Roudas M, von Schulthess GK, Tutic M, Moch H, Stahel RA, Steinert HC: Etiology of solitary extrapulmonary positron emission tomography and computed tomography findings in patients with lung cancer. J Clin Oncol; 2005 Oct 1;23(28):6846-53
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  • Histopathologic examinations of these 32 lesions revealed a second clinically unsuspected malignancy or a recurrence of a previous diagnosed carcinoma in six patients (19%) and a benign tumor or inflammatory lesion in 26 patients (81%).
  • Benign tumors and inflammatory lesions included eight colon adenomas, four Warthin's tumors, one granuloma of the lower jaw, one adenoma of the thyroid gland, one compensatory muscle activity due to vocal chord palsy, two occurrences of arthritis, three occurrences of reflux esophagitis, two occurrences of pancreatitis, two occurrences of diverticulitis, one hemorrhoidal inflammation, and one rib fracture.
  • CONCLUSION: Solitary extrapulmonary FDG accumulations in patients with newly diagnosed lung cancer should be analyzed critically for correct staging and optimal therapy, given that up to half of the lesions may represent unrelated malignancies or benign disease.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / radionuclide imaging. Lung Neoplasms / radionuclide imaging. Neoplasm Metastasis / radionuclide imaging. Positron-Emission Tomography
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Fluorodeoxyglucose F18. Humans. Inflammation. Male. Middle Aged. Neoplasm Staging. Prospective Studies. Radiopharmaceuticals. Sensitivity and Specificity. Tomography, X-Ray Computed

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  • (PMID = 16192576.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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34. Carlini M, Giovannini C, Castaldi F, Mercadante E, Dell'Avanzato R, Zazza S, Nania A, Santeusanio G, Passeri M, Di Perna P: High risk for microcarcinoma in thyroid benign diseases. Incidence in a one year period of total thyroidectomies. J Exp Clin Cancer Res; 2005 Jun;24(2):231-6
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  • [Title] High risk for microcarcinoma in thyroid benign diseases. Incidence in a one year period of total thyroidectomies.
  • The discovery of new cases depends on the progress of the diagnostics (US scan, fine needle biopsy and cytology, CT, MRI), on the extended indications to thyroidectomy for benign disease and on the attention in pathologic examination of the specimen.
  • The clinical evolution of this disease is not well known: in spite of a high incidence reported in some autoptic series, suggesting that this tumour could have a good prognosis, some authors report an overall incidence of up to 11% of local recurrence, metastasis and mortality.
  • Aim of this study was to estimate the incidence and the clinico-pathological findings of TMC over a one year period of total thyroidectomies for diffuse benign thyroid diseases, and to evaluate, on the basis of the frequency of incidental microcarcinoma, if the surgical procedure of complete removal of the gland should be adopted in any case.
  • Total thyroidectomy confirmed to be the treatment of choice for diffuse benign diseases and appeared necessary to obtain both, diagnosis and treatment of incidental TMC.
  • [MeSH-minor] Adult. Aged. Biopsy. Female. Humans. Incidence. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Metastasis. Recurrence. Risk. Thyroidectomy. Tomography, X-Ray Computed. Ultrasonics

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  • [ErratumIn] J Exp Clin Cancer Res. 2007 Mar;26(1):2. Dell'Avanzato [corrected to Dell'Avanzato, R]
  • (PMID = 16110756.001).
  • [ISSN] 0392-9078
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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35. Sit KY, Chui WH, Wang E, Chiu SW: Multiple pulmonary metastases from benign pleomorphic adenoma. Asian Cardiovasc Thorac Ann; 2008 Jan;16(1):62-4
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  • [Title] Multiple pulmonary metastases from benign pleomorphic adenoma.
  • Metastasizing pleomorphic adenoma is a rare condition of metastasis from a histologically benign salivary gland tumor.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Incidental Findings. Lung Neoplasms / secondary. Neoplasm Recurrence, Local. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Humans. Male. Middle Aged. Radiography, Thoracic. Thoracic Surgery, Video-Assisted. Tomography, X-Ray Computed

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  • (PMID = 18245710.001).
  • [ISSN] 1816-5370
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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36. Yu K, Liu Y, Wang H, Hu S, Long C: Epidemiological and pathological characteristics of cardiac tumors: a clinical study of 242 cases. Interact Cardiovasc Thorac Surg; 2007 Oct;6(5):636-9
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  • Of primary cardiac tumors, the incidence of benign neoplasm was much higher than malignant masses (90.6% vs. 9.4%, P<0.01).
  • The most common benign cardiac tumor was myxoma (86.8%).
  • Benign non-myxoma tumors are more likely to occur in the ventricular (64.3%).
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Child. Child, Preschool. China / epidemiology. Female. Humans. Incidence. Infant. Male. Middle Aged. Neoplasm Metastasis. Prevalence. Retrospective Studies. Sex Distribution

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  • (PMID = 17670730.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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37. Ceppi P, Volante M, Ferrero A, Righi L, Rapa I, Rosas R, Berruti A, Dogliotti L, Scagliotti GV, Papotti M: Thymidylate synthase expression in gastroenteropancreatic and pulmonary neuroendocrine tumors. Clin Cancer Res; 2008 Feb 15;14(4):1059-64
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  • Similarly, in GEP tumors, a higher TS expression in poorly differentiated carcinomas than both WD-NEC and benign tumors (P < 0.01) was found.
  • [MeSH-major] Digestive System Neoplasms / enzymology. Drug Resistance, Neoplasm / physiology. Lung Neoplasms / enzymology. Neuroendocrine Tumors / enzymology. Thymidylate Synthase / biosynthesis

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  • (PMID = 18281538.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / RNA, Messenger; EC 2.1.1.45 / Thymidylate Synthase; U3P01618RT / Fluorouracil
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38. Oda M: [Completion pneumonectomy]. Kyobu Geka; 2010 Jul;63(8 Suppl):719-23
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  • The indications of CP include both benign and malignant diseases and it is more demanding technical procedure with high morbidity and mortality compared to standardized pneumonectomy.
  • [MeSH-minor] Humans. Neoplasm, Residual / surgery. Reoperation

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  • (PMID = 20715447.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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39. Nazir SA, Raza SA, Nazir S, Sherwood W, Bowker C, Lakhoo K: Challenges in the prenatal and post-natal diagnosis of mediastinal cystic hygroma: a case report. J Med Case Rep; 2008;2:256
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  • INTRODUCTION: Cystic hygroma is a benign congenital neoplasm that mostly presents as a soft-tissue mass in the posterior triangle of the neck.
  • An echocardiogram and thoracic computed tomography scan confirmed a complex multiloculated cystic mediastinal mass.

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  • (PMID = 18673546.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2518156
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40. Selch MT, Lin K, Agazaryan N, Tenn S, Gorgulho A, DeMarco JJ, DeSalles AA: Initial clinical experience with image-guided linear accelerator-based spinal radiosurgery for treatment of benign nerve sheath tumors. Surg Neurol; 2009 Dec;72(6):668-74; discussion 674-5
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  • [Title] Initial clinical experience with image-guided linear accelerator-based spinal radiosurgery for treatment of benign nerve sheath tumors.
  • Tumor location was cervical 11, lumbar 10, and thoracic 4.
  • Tumor size varied from 0.9 to 4.1 cm (median, 2.1 cm).
  • Tumor size remained stable in 18 cases, and 7 (28%) demonstrated more than 2 mm reduction in tumor size.
  • CONCLUSIONS: Results of this limited experience indicate linear accelerator-based spinal radiosurgery is feasible for treatment of benign nerve sheath tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / surgery. Neurofibromatosis 1 / diagnosis. Neurofibromatosis 1 / surgery. Neurofibromatosis 2 / diagnosis. Neurofibromatosis 2 / surgery. Neurologic Examination. Postoperative Complications / diagnosis. Young Adult

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  • [Copyright] Copyright 2009 Elsevier Inc. All rights reserved.
  • (PMID = 19608232.001).
  • [ISSN] 1879-3339
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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41. Nussbaumer P, Furrer M: [The role of video-thoracoscopy in thoracic surgery]. Ther Umsch; 2005 Feb;62(2):77-84
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  • [Title] [The role of video-thoracoscopy in thoracic surgery].
  • The widespread acceptance of minimal invasive techniques has revolutionized the practice of surgery including, thoracic surgery.
  • Within a short period of time, video-assisted thoracic surgery (VATS) has become an acceptable approach to a wide range of thoracic procedures.
  • For therapeutic procedures, VATS has also been generally accepted as the treatment for spontaneous pneumothorax, thoracic sympathectomy, treatment of loculated effusions and resection of simple mediastinal cysts and benign tumors.
  • [MeSH-major] Thoracic Surgery, Video-Assisted
  • [MeSH-minor] Aged. Carcinoma, Bronchogenic / diagnosis. Carcinoma, Bronchogenic / pathology. Carcinoma, Renal Cell. Diagnosis, Differential. Empyema, Pleural / surgery. Humans. Kidney Neoplasms. Lung / pathology. Lung / surgery. Lung Neoplasms / diagnosis. Lung Neoplasms / pathology. Lung Neoplasms / secondary. Male. Mediastinal Cyst / diagnosis. Mediastinal Cyst / surgery. Neoplasm Staging. Pleural Effusion / diagnosis. Pleural Effusion / surgery. Pneumothorax / diagnosis. Pneumothorax / surgery. Sympathectomy. Thymectomy. Tomography, X-Ray Computed

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  • (PMID = 15756915.001).
  • [ISSN] 0040-5930
  • [Journal-full-title] Therapeutische Umschau. Revue thérapeutique
  • [ISO-abbreviation] Ther Umsch
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 51
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42. Iagaru A, Chawla S, Menendez L, Conti PS: 18F-FDG PET and PET/CT for detection of pulmonary metastases from musculoskeletal sarcomas. Nucl Med Commun; 2006 Oct;27(10):795-802
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  • [(18)F]Fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) has a role in differentiating sarcomas from benign tumours and assessing the response to therapy in advanced sarcomas.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / pathology. Male. Middle Aged. Neoplasm Metastasis. Radiography, Thoracic / methods. Retrospective Studies

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  • (PMID = 16969262.001).
  • [ISSN] 0143-3636
  • [Journal-full-title] Nuclear medicine communications
  • [ISO-abbreviation] Nucl Med Commun
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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43. Suehiro K, Pritzwald-Stegmann P, Lee KM, Teoh HH, Alison PM: Mediastinal and pulmonary metastases of malignant ossifying fibromyxoid tumor. Ann Thorac Surg; 2006 Jun;81(6):2289-91
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  • [Title] Mediastinal and pulmonary metastases of malignant ossifying fibromyxoid tumor.
  • Ossifying fibromyxoid tumor is usually a benign tumor.
  • However some of these tumors with histologic and clinical evidence of malignancy have also been reported and little information is available regarding surgery for metastatic ossifying fibromyxoid tumor.
  • We present a case involving extensive excision of a huge metastatic ossifying fibromyxoid tumor occupying the upper mediastinum and upper half of the right hemithorax.
  • [MeSH-minor] Adult. Brain Neoplasms / complications. Brain Neoplasms / secondary. Diagnostic Errors. Fatal Outcome. Female. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / surgery. Humans. Lipoma / diagnosis. Neoplasm Invasiveness. Pericardium / pathology. Pericardium / surgery. Phrenic Nerve / pathology. Phrenic Nerve / surgery. Pneumonectomy. Radiotherapy, Adjuvant. Reoperation. Seizures / etiology. Skin Neoplasms / pathology. Skin Neoplasms / surgery. Superior Vena Cava Syndrome / etiology

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  • (PMID = 16731174.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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44. Jacot W, Lhermitte L, Dossat N, Pujol JL, Molinari N, Daurès JP, Maudelonde T, Mangé A, Solassol J: Serum proteomic profiling of lung cancer in high-risk groups and determination of clinical outcomes. J Thorac Oncol; 2008 Aug;3(8):840-50
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  • METHODS: In the present study, we developed a serum proteomic fingerprinting approach coupled with a three-step classification method to address two important clinical questions: (i) to determine whether or not proteomic profiling differs between lung cancer and benign lung diseases in a population of smokers and (ii) to assess the prognostic impact of this profiling in lung cancer.
  • Proteomic spectra were obtained from 170 pathologically confirmed lung cancer or smoking patients with benign chronic lung disease serum samples.
  • RESULTS: Among the 228 protein peaks differentially expressed in the whole population, 88 differed significantly between lung cancer patients and benign lung disease, with area under the curve diagnostic values ranging from 0.63 to 0.84.
  • Multiprotein classifiers based on differentially expressed peaks allowed the classification of lung cancer and benign disease with an area under the curve ranging from 0.991 to 0.994.
  • [MeSH-major] Biomarkers, Tumor / blood. Carcinoma, Non-Small-Cell Lung / blood. Lung Neoplasms / blood. Proteome / analysis
  • [MeSH-minor] Adenocarcinoma / blood. Adenocarcinoma / classification. Adenocarcinoma / secondary. Aged. Aged, 80 and over. Carcinoma, Large Cell / classification. Carcinoma, Large Cell / diagnosis. Carcinoma, Large Cell / secondary. Carcinoma, Squamous Cell / classification. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / secondary. DNA Fingerprinting / methods. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Proteomics / methods. ROC Curve. Risk Factors. Small Cell Lung Carcinoma / classification. Small Cell Lung Carcinoma / diagnosis. Small Cell Lung Carcinoma / secondary. Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization. Survival Rate

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  • (PMID = 18670301.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Proteome
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45. Ramos-Font C, Santiago Chinchilla A, Rebollo Aguirre AC, Rodríguez Fernández A, Medina Benítez A, Llamas Elvira JM: [Desmoid tumor of the thoraco-abdominal wall characterized with 18F-fluorodeoxyglucose PET/ CT scan. Correlation with magnetic resonance and bone scintigraphy. Review of the literature]. Rev Esp Med Nucl; 2009 Mar-Apr;28(2):70-3
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  • [Title] [Desmoid tumor of the thoraco-abdominal wall characterized with 18F-fluorodeoxyglucose PET/ CT scan. Correlation with magnetic resonance and bone scintigraphy. Review of the literature].
  • [Transliterated title] Tumor desmoide de la pared torácico-abdominal. Caracterización con PET-TAC con 18F-fluorodesoxiglucosa y correlación con resonancia magnética y gammagrafía ósea. Revisión de la literatura.
  • Desmoid tumours are uncommon benign tumours but with aggressive behaviour, resulting from the proliferation of well-differentiated fibroblasts.
  • When planning treatment, it is important to assess the correct tumour extent to permit curative radical surgery minimizing possible local recurrence.
  • We present the case of a patient with a desmoid tumour of the abdominal-chest wall and we review the related literature.
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness. Thoracic Wall / pathology. Thoracic Wall / radiography. Thoracic Wall / radionuclide imaging

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  • (PMID = 19406052.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] spa
  • [Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Fluorine Radioisotopes; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 22
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46. Gopalakrishnan M, Benjamin M, Kamath M, Thekkepurackal R: Cardiac myxoma mimicking extension of renal cell carcinoma. Interact Cardiovasc Thorac Surg; 2010 May;10(5):816-7
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  • Cardiac myxomas are the commonest benign tumour of the heart.
  • Since there was no single reported case of myxoma with RCC, a presumptive diagnosis of RCC with right atrial extension of tumour thrombus was made.
  • [MeSH-minor] Biopsy, Needle. Cardiac Surgical Procedures / methods. Follow-Up Studies. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Nephrectomy / methods. Risk Assessment. Treatment Outcome

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  • [Copyright] 2010 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.
  • (PMID = 20154070.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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47. Marshall AE, Martin SE, Agaram NP, Chen JH, Horn EM, Douglas-Akinwande AC, Hattab EM: A 61-year-old woman with osteomalacia and a thoracic spine lesion. Brain Pathol; 2010 Mar;20(2):499-502
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  • [Title] A 61-year-old woman with osteomalacia and a thoracic spine lesion.
  • Phosphaturic mesenchymal tumor, mixed connective tissue variant (PMT-MCT) is a rare, largely benign, mesenchymal neoplasm almost invariably associated with oncogenic osteomalacia.
  • We report a case of a 61-year-old female with long-standing osteomalacia who was found to have PMT-MCT of the thoracic spine.
  • [MeSH-major] Osteomalacia / diagnosis. Osteomalacia / pathology. Spinal Neoplasms / diagnosis. Spinal Neoplasms / pathology. Thoracic Vertebrae

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  • (PMID = 20438469.001).
  • [ISSN] 1750-3639
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
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48. Kim K, Kim HK, Park JS, Chang SW, Choi YS, Kim J, Shim YM: Video-assisted thoracic surgery lobectomy: single institutional experience with 704 cases. Ann Thorac Surg; 2010 Jun;89(6):S2118-22
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  • [Title] Video-assisted thoracic surgery lobectomy: single institutional experience with 704 cases.
  • BACKGROUND: During the past decade, video-assisted thoracic surgery (VATS) lobectomy has been performed with increasing frequency in patients with early-stage non-small cell lung cancer (NSCLC).
  • RESULTS: Between 2003 and 2008, 704 patients underwent VATS lobectomy for the following indications: NSCLC (n = 548), carcinoid tumors (n = 7), pulmonary metastases (n = 22), and benign diseases (n = 127).
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / surgery. Lung Neoplasms / surgery. Pneumonectomy / methods. Thoracic Surgery, Video-Assisted
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Feasibility Studies. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Retrospective Studies. Survival Rate. Time Factors. Young Adult

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  • [Copyright] 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20493994.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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49. Lian X, Zhao J, Hou T, Ma H, Chen Z: Benign intraspinal osteoblastoma stemming from C7 lamina in cervicothoracic junction: a case report. Spine (Phila Pa 1976); 2006 Nov 1;31(23):E895-9
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  • [Title] Benign intraspinal osteoblastoma stemming from C7 lamina in cervicothoracic junction: a case report.
  • STUDY DESIGN: A case report of a rare benign osteoblastoma successfully treated with total en bloc excision.
  • SUMMARY OF BACKGROUND DATA: A rare case of massive benign osteoblastoma stemming from left side lamina of C7 and extension to spinal canal from C6 to T1 resulting in spinal cord compressed severely is reported.
  • A massive neoplasm located in intraspinal cervicothoracic junction and the spinal cord compressed severely was shown in radiographs, MRI, and CT.
  • The neoplasm was removed totally with instrumentation performed in surgical intervention.
  • Recurrence of the tumor was not seen at the final follow-up.
  • [MeSH-minor] Adolescent. Female. Humans. Magnetic Resonance Imaging. Pain / etiology. Spinal Cord Compression / diagnosis. Spinal Cord Compression / etiology. Thoracic Vertebrae / radiography. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17077728.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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50. Storch I, Shah M, Thurer R, Donna E, Ribeiro A: Endoscopic ultrasound-guided fine-needle aspiration and Trucut biopsy in thoracic lesions: when tissue is the issue. Surg Endosc; 2008 Jan;22(1):86-90
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  • [Title] Endoscopic ultrasound-guided fine-needle aspiration and Trucut biopsy in thoracic lesions: when tissue is the issue.
  • The aims of this study are to evaluate the safety of EUS TCB in thoracic lesions and to compare the diagnostic accuracy of TCB with FNA and FNA + TCB.
  • Twenty-nine patients had malignant disease and 19 had benign disorders.
  • EUS TCB was better than FNA for benign diseases (89% vs. 63%, p = 0.04).
  • EUS-guided TCB should be considered in patients with benign disorders of the mediastinum when other modalities fail to yield a diagnosis.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cohort Studies. Female. Humans. Immunohistochemistry. Lymph Nodes / diagnostic imaging. Lymph Nodes / pathology. Male. Mediastinal Diseases / diagnostic imaging. Mediastinal Diseases / pathology. Middle Aged. Neoplasm Invasiveness / diagnostic imaging. Neoplasm Invasiveness / pathology. Probability. Retrospective Studies. Risk Assessment. Sensitivity and Specificity

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  • (PMID = 17479313.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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51. Kiroglu Y, Benek B, Yagci B, Cirak B, Tahta K: Spinal cord compression caused by vertebral hemangioma being symptomatic during pregnancy. Surg Neurol; 2009 Apr;71(4):487-92; discussion 492
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  • BACKGROUND: Hemangioma is one of the most common benign tumors of the spine, and it remains silent in the vast majority of subjects afflicted.
  • [MeSH-major] Hemangioma / pathology. Pregnancy Complications, Neoplastic / pathology. Spinal Cord Compression / etiology. Spinal Cord Compression / pathology. Spinal Neoplasms / pathology. Thoracic Vertebrae / pathology
  • [MeSH-minor] Angiography. Back Pain / etiology. Cesarean Section. Embolization, Therapeutic. Female. Humans. Magnetic Resonance Imaging. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / radiography. Neoplasm Recurrence, Local / surgery. Paraplegia / etiology. Pregnancy. Reconstructive Surgical Procedures / instrumentation. Reconstructive Surgical Procedures / methods. Reoperation. Spinal Canal / pathology. Spinal Canal / radiography. Treatment Outcome. Vertebroplasty / instrumentation. Vertebroplasty / methods. Young Adult


52. Cranshaw IM, Gikas PD, Fisher C, Thway K, Thomas JM, Hayes AJ: Clinical outcomes of extra-thoracic solitary fibrous tumours. Eur J Surg Oncol; 2009 Sep;35(9):994-8
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  • [Title] Clinical outcomes of extra-thoracic solitary fibrous tumours.
  • BACKGROUND: Extra-thoracic solitary fibrous tumours (ESFTs) have traditionally been regarded as indolent neoplasms similar to their intra-thoracic counterparts.
  • PATIENTS/METHODS: All patients with a histopathological diagnosis of solitary fibrous tumour (SFT) who presented to the Royal Marsden Hospital between 1998 and 2006 were reviewed.
  • Locoregional recurrent disease was more common in those with malignant histopathological findings compared to those with benign histopathology (6/18 vs 0/15 p 0.021).
  • The presence of malignant histopathology was the only factor to affect survival with no benign cases dying of disease and malignant cases having a median survival of 59 months (p 0.003).
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. London. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 19345055.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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53. McIntosh J, Sylvester PA, Virjee J, Callaway M, Thomas MG: Pulmonary staging in colorectal cancer--is computerised tomography the answer? Ann R Coll Surg Engl; 2005 Sep;87(5):331-3
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  • The aim of this study was to assess the value of pre-operative thoracic CT for pulmonary staging in CRC.
  • The CXRs of those patients in whom a radiological abnormality was seen on thoracic CT were reviewed blindly by an independent consultant radiologist.
  • In those patients diagnosed with CRC, nine (24%) had an abnormality on thoracic CT.
  • Four patients with positive thoracic CTs had chemotherapy and or radiotherapy with no surgery.
  • In addition, one of the patients underwent multiple, non-diagnostic thoracic investigations prior to a diagnosis of sarcoidosis being made and then proceeding to surgery.
  • An independent consultant radiologist reviewed seven out of the nine CXRs of patients with an abnormality on thoracic CT without knowledge of the clinical diagnosis, and reported three of the CXRs to be normal.
  • CONCLUSIONS: Thoracic CT appears to improve the accuracy of pulmonary staging in CRC allowing a more appropriate level of intervention.
  • However, CT is likely to identify more benign radiological abnormalities than CXR alone, and investigations should not occur to the detriment of treating the primary tumour.
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Staging / methods. Neoplasm Staging / standards. Prospective Studies. Sensitivity and Specificity


54. Li BJ, Huang XP, Wei WD, Wang JY, Su XD, Zhang X, Hong WS, Tang J, Zhang LJ, Long H, Yang MT, Rong TH: [Expression and clinical significance of cytokeratin 19 in bone marrow of patients with breast cancer]. Ai Zheng; 2005 Jun;24(6):735-9
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  • METHODS: Expression of CK19 mRNA in bone marrows of 65 breast cancer patients, 15 benign breast disease patients, and 8 healthy volunteers was detected by reverse transcription-polymerase chain reaction (RT-PCR).
  • RESULTS: Positive rate of CK19 mRNA was 33.8% in the 65 breast cancer patients, and 0 in both benign breast disease patients and healthy volunteers.
  • Expression of CK19 mRNA was positively correlated with tumor size and clinical stage (P < 0.05), but was not related to age and lymph node status (P > 0.05).
  • [MeSH-minor] Adult. Aged. Breast Neoplasms, Male / metabolism. Breast Neoplasms, Male / pathology. Carcinoembryonic Antigen / blood. Female. Fibroadenoma / blood. Fibroadenoma / metabolism. Fibroadenoma / pathology. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. RNA, Messenger / biosynthesis. RNA, Messenger / genetics

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  • (PMID = 15946491.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Keratin-19; 0 / RNA, Messenger
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55. Na JH, Kim HS, Eoh W, Kim JH, Kim JS, Kim ES: Spinal cord hemangioblastoma : diagnosis and clinical outcome after surgical treatment. J Korean Neurosurg Soc; 2007 Dec;42(6):436-40
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  • OBJECTIVE: Spinal cord hemangioblastoma is an uncommon vascular neoplasm with a benign nature and is associated with von Hippel-Lindau (VHL) disease in 20-30% of patients.
  • RESULTS: Six patients had intramedullary tumor, and the remaining patients had intradural extramedullary lesions.
  • Tumors were located in the cervical cord in five cases and in the thoracic cord in four cases.

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  • (PMID = 19096585.001).
  • [ISSN] 2005-3711
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2588179
  • [Keywords] NOTNLM ; Hemangioblastoma / Mutation analysis / Von Hippel-Lindau disease
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56. Loh JK, Lin CK, Hwang YF, Hwang SL, Kwan AL, Howng SL: Primary spinal tumors in children. J Clin Neurosci; 2005 Apr;12(3):246-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Two tumors were located primarily in the cervical cord (1 meningioma, 1 neurofibroma), five were predominantly thoracic (1 lymphoma, 1 meningioma, 1 astrocytoma, 1 fibrosarcoma and 1 osteoblastoma), one lumbar (ependymoma), and one sacral (Ewing's sarcoma).
  • Five children with benign tumors improved postoperatively.
  • Radical surgery should be considered in benign primary spinal cord tumors.
  • [MeSH-minor] Adolescent. Back Pain / etiology. Child. Child, Preschool. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Laminectomy. Male. Muscle Weakness / etiology. Neoplasm Recurrence, Local / epidemiology. Neurosurgical Procedures. Retrospective Studies. Treatment Outcome

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  • (PMID = 15851074.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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57. Kozower BD, Meyers BF, Reed CE, Jones DR, Decker PA, Putnam JB Jr: Does positron emission tomography prevent nontherapeutic pulmonary resections for clinical stage IA lung cancer? Ann Thorac Surg; 2008 Apr;85(4):1166-9; discussion 1169-70
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  • However, the benefit of PET in clinical stage IA patients has been questioned due to the lower prevalence of metastases and poor ability to discriminate benign from malignant lung lesions.
  • This study evaluates whether PET prevents nontherapeutic pulmonary resections in clinical stage IA patients by finding advanced disease or by declaring a nodule as benign.
  • The negative predictive value of PET to predict benign lesions was only 57% (16 of 28; 95% CI, 37.2 to 75.5).
  • [MeSH-minor] Aged. Biopsy, Needle. Cohort Studies. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Predictive Value of Tests. Prospective Studies. Risk Assessment. Sensitivity and Specificity. Survival Analysis. Treatment Outcome


58. Picquet J, Blin V, Dussaussoy C, Jousset Y, Papon X, Enon B: Surgical reconstruction of the superior vena cava system: indications and results. Surgery; 2009 Jan;145(1):93-9
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  • BACKGROUND: Obstruction of the superior vena cava (SVC) secondary to malignant or benign diseases is rarely treated by surgical reconstruction.
  • The underlying disease was primary bronchopulmonary malignant neoplasm in 50%, mediastinal malignant neoplasm in 21%, and symptomatic benign disease in 29%.
  • Mortality was 0% for patients with benign disease.
  • Our experience suggests that the need for SVC reconstruction should not, however, be considered as a contraindication for resection of a bronchopulmonary or mediastinal neoplasm in an otherwise potentially curable patient, provided it can be achieved in a single block with clear margins.
  • Replacement of the SVC can also be performed with low mortality and morbidity for effective treatment of SVCC secondary to benign disease that fails to respond to medical therapy.

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  • (PMID = 19081480.001).
  • [ISSN] 1532-7361
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9002-84-0 / Polytetrafluoroethylene
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59. Németh T, Furák J, Wolfárd A, Géczi T, Tiszlavicz L, Lázár G: [Surgical treatment of primary pleural tumours in our department]. Magy Seb; 2010 Apr;63(2):67-74
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  • The tumors were classified into the following groups: benign local fibrous tumors (benign LFTP; n = 15), recurrent malignant fibrous tumors (recurrent malignant LFTP; n = 2) and malignant mesotheliomas (MPM; n = 12).
  • Complete resections of benign LFTPs were performed, with additional resection of the chest wall and lobectomy in two cases.
  • [MeSH-minor] Aged. Biopsy. Carcinoma / surgery. Female. Humans. Hungary. Male. Mesothelioma / surgery. Middle Aged. Neoplasm Staging. Pleurodesis. Pneumonectomy. Retrospective Studies. Sarcoma / surgery. Thoracic Surgery, Video-Assisted. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20400397.001).
  • [ISSN] 0025-0295
  • [Journal-full-title] Magyar sebészet
  • [ISO-abbreviation] Magy Seb
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
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60. Kozlowski M, Kowalczuk O, Milewski R, Chyczewski L, Niklinski J, Laudański J: Serum vascular endothelial growth factors C and D in patients with oesophageal cancer. Eur J Cardiothorac Surg; 2010 Sep;38(3):260-7
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  • METHODS: Serum VEGF-C and sVEGF-D were measured by enzyme-linked immunoadsorbent assay (ELISA) on 149 patients with oesophageal cancer, 29 patients with benign oesophageal diseases and 30 healthy controls.
  • RESULTS: Serum VEGF-C and sVEGF-D levels were significantly higher in patients with oesophageal carcinoma than in the control group (p<0.001 and p=0.001, respectively) or in the benign oesophageal diseases group (p=0.04 and p=0.03, respectively).
  • Subgroup analysis showed that lymph node metastasis (p=0.001), stage (p=0.001), tumour depth (p=0.006), resectability (p=0.002), tumour size (p=0.01), distant metastases (p=0.01) and histological grading (p=0.04) were correlated with an elevated level of sVEGF-C.
  • Elevated levels of sVEGF-D were associated with tumour depth (p=0.002), stage (p=0.01) and lymph node metastasis (p=0.02).
  • On univariate regression analysis, tumour size, tumour depth, stage, lymph node metastases, distant metastases, resectability and sVEGF-C were found to be significant prognostic factors.
  • [MeSH-major] Biomarkers, Tumor / blood. Esophageal Neoplasms / diagnosis. Vascular Endothelial Growth Factor C / blood. Vascular Endothelial Growth Factor D / blood
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Diagnosis, Differential. Epidemiologic Methods. Esophageal Diseases / diagnosis. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Proteins / metabolism. Neoplasm Staging. Prognosis. Treatment Outcome

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  • [Copyright] Copyright 2010. Published by Elsevier B.V.
  • (PMID = 20226684.001).
  • [ISSN] 1873-734X
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Vascular Endothelial Growth Factor C; 0 / Vascular Endothelial Growth Factor D
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61. Horan G, Rafique A, Robson J, Dixon AK, Williams MV: CT of the chest can hinder the management of seminoma of the testis; it detects irrelevant abnormalities. Br J Cancer; 2007 Mar 26;96(6):882-5
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  • Overall 18 cases required additional investigations and follow-up for abnormalities subsequently found to be benign.
  • [MeSH-major] Radiography, Thoracic / methods. Seminoma / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. False Positive Reactions. Humans. Male. Middle Aged. Neoplasm Staging. Orchiectomy. Retrospective Studies. Tomography, X-Ray Computed / methods

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  • (PMID = 17375035.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
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62. Ahn Y, Chang H, Lim YS, Hah JH, Kwon TK, Sung MW, Kim KH: Primary tracheal tumors: review of 37 cases. J Thorac Oncol; 2009 May;4(5):635-8
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  • INTRODUCTION: Primary tracheal tumors are rare, and composed of various benign and malignant pathologies.
  • METHODS: From January 1989 through December 2006, 37 patients (14 with benign tumors, 23 with malignant tumors) were treated in a tertiary referral center.
  • RESULTS: Benign tumors comprised of various pathologies.
  • CONCLUSION: Papillomas were difficult to manage, however, other benign tumors were successfully treated.
  • [MeSH-minor] Adolescent. Adult. Aged. Child, Preschool. Female. Humans. Infant. Male. Medical Records. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Rate. Young Adult

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  • (PMID = 19357541.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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63. Congregado M, Merchan RJ, Gallardo G, Ayarra J, Loscertales J: Video-assisted thoracic surgery (VATS) lobectomy: 13 years' experience. Surg Endosc; 2008 Aug;22(8):1852-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Video-assisted thoracic surgery (VATS) lobectomy: 13 years' experience.
  • BACKGROUND: Major lung resection by video-assisted thoracic surgery (VATS) has been proven to be both safe and technically feasible, but is not routinely performed in most hospitals.
  • METHODS: We have performed a retrospective review included all patients undergoing major pulmonary resection by VATS at the General and Thoracic Surgery Unit, Virgen Macarena University Hospital, Seville (Spain) since 1992.
  • RESULTS: A total of 237 major pulmonary resections were performed, on 203 males and 34 males, with a mean age of 61.43 years (non-small-cell bronchogenic carcinoma: 204, benign processes: 24, carcinoid tumors: 4, and lobectomy due to metastases: 5).
  • In our experience, VATS is currently to be considered ideally indicated for certain benign processes and for T1-T2 N0 M0 bronchogenic carcinomas.
  • [MeSH-major] Lung / surgery. Thoracic Surgery, Video-Assisted
  • [MeSH-minor] Adolescent. Adult. Aged. Carcinoid Tumor / surgery. Carcinoma, Bronchogenic / surgery. Child. Female. Follow-Up Studies. Humans. Length of Stay. Lung Diseases / surgery. Lung Neoplasms / pathology. Lung Neoplasms / surgery. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local. Neoplasm Staging. Pneumonectomy / adverse effects. Retrospective Studies. Survival Analysis. Time Factors

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  • (PMID = 18157567.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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64. Abu-Omar Y, Mezue K, Ali A, Kneeshaw JD, Goddard M, Large SR: Intractable ventricular tachycardia secondary to cardiac hemangioma. Ann Thorac Surg; 2010 Oct;90(4):1347-9
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  • We report a case of intractable ventricular tachycardia in a middle-aged man developing on a background of known, presumed benign, cardiac neoplasm.
  • Appearances at histopathology were those of a benign intracardiac hemangioma.

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  • [Copyright] Copyright © 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • [CommentIn] Ann Thorac Surg. 2011 Oct;92(4):1553; author reply 1553-4 [21958830.001]
  • (PMID = 20868844.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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65. Roh JL, Ryu CH, Kim JS, Lee JS, Choi SH, Nam SY, Kim SY: Clinical significance of intrathoracic lesions detected by 18F-fluorodeoxyglucose positron emission tomography in the management of patients with head and neck cancer. Oral Oncol; 2007 Sep;43(8):757-63
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  • Few studies have used positron emission tomography (PET) to identify metastases or simultaneous thoracic malignancies in patients with head and neck cancer (HNC).
  • We retrospectively investigated the role of (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in detecting thoracic malignancies in patients with previously untreated HNC.
  • The accuracy of FDG PET and CT were drawn from patients in whom diagnosis was confirmed, by histopathology or follow-up imaging, and risk factors for thoracic malignancy were analyzed.
  • Most of the lesions (83%) with abnormal FDG uptake were benign, with thoracic malignancy confirmed in 15 patients (17%).
  • The likelihood of thoracic malignancy in the HNC patients was associated with high FDG uptake of thoracic lesions.
  • The thoracic staging by FDG PET may be helpful in therapeutic planning for these patients.
  • [MeSH-minor] Adolescent. Adult. Aged. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / radiography. Carcinoma, Squamous Cell / radionuclide imaging. Carcinoma, Squamous Cell / secondary. Female. Fluorodeoxyglucose F18. Humans. Image Interpretation, Computer-Assisted / methods. Male. Middle Aged. Neoplasm Staging. Radiopharmaceuticals. Retrospective Studies. Risk Factors. Sensitivity and Specificity. Tomography, X-Ray Computed

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  • (PMID = 17112773.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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66. Böthig R, Rogosch KU, Mach P, Mahn B, Burgdörfer H: [Testicular metastases as primary manifestation of malignant melanoma at known melanocytoma]. Aktuelle Urol; 2006 Mar;37(2):138-40
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  • The transformation of a benign, meningeal melanocytoma into a malignant melanoma has only been described once world-wide.
  • The problems in the diagnosis and therapy of this extremely rare tumor are discussed on the basis of a further patient with metastases of the testes as primary manifestation of a malignant melanoma.
  • The case history disclosed operations 10 and 3.5 year earlier for an apparently benign melanocytoma at the level of the 11th and 12th thoracic vertebrae, a local recurrence with paraparesis was known at the time of admission.
  • Sonography revealed an inhomogeneous tumor effecting the entire left testicle.
  • Radical orchiectomy is the treatment of choice for a suspected primary testicular tumor.
  • In elderly patients with unclear testicular tumors metastases from an (occult) tumor disease must be taken into consideration.
  • [MeSH-minor] Aged. Diagnosis, Differential. Disease Progression. Humans. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness / pathology. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Orchiectomy. Testis / pathology. Ultrasonography

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  • (PMID = 16625471.001).
  • [ISSN] 0001-7868
  • [Journal-full-title] Aktuelle Urologie
  • [ISO-abbreviation] Aktuelle Urol
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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67. Liu Z, Xu S, Xiao N, Song C, Zhang H, Li F: [Overexpression of IL-8 and MMP-9 confer high malignant phenotype in patients with non-small cell lung cancer]. Zhongguo Fei Ai Za Zhi; 2010 Aug;13(8):795-802
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  • BACKGROUND AND OBJECTIVE: IL-8 (interleukin-8) has been identified as a chemotactic factor, but recent found that IL-8 and matrix metalloproteinase-9 (MMP-9) are important cytokines which are closely related to the growth and metastasis of tumor.
  • The aim of this study is to explore the relationship between IL-8, MMP-9 expressions and clinical pathological features of non-small cell lung cancer (NSCLC) patients and evaluate the diagnostic potential of IL-8, MMP-9 as tumor markers.
  • METHODS: The serum levels of IL-8 and MMP-9 were detected by enzyme-linked immunosorbentassay (ELISA) in 141 NSCLC patients, 40 healthy adults and 40 patients with benign pulmonary disease.
  • The expressions of IL-8 and MMP-9 were detected by immunohistochemical method in 95 NSCLC tissues, and 21 benign disease lung tissues, 25 normal lung tissues as control.
  • RESULTS: The level of expression of IL-8 and MMP-9 in serum and tissue of NSCLC was significantly higher than that of healthy and benign respiratory disease, and the expression was gradually increased with the upgrade of clinicopathological stage.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Case-Control Studies. Female. Humans. Male. Middle Aged. Neoplasm Metastasis

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  • (PMID = 20704821.001).
  • [ISSN] 1999-6187
  • [Journal-full-title] Zhongguo fei ai za zhi = Chinese journal of lung cancer
  • [ISO-abbreviation] Zhongguo Fei Ai Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Interleukin-8; EC 3.4.24.35 / Matrix Metalloproteinase 9
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68. Piyavisetpat N, Aquino SL, Hahn PF, Halpern EF, Thrall JH: Small incidental pulmonary nodules: how useful is short-term interval CT follow-up? J Thorac Imaging; 2005 Feb;20(1):5-9
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  • PURPOSE: To determine whether short-term (<6 month) follow-up imaging by thoracic CT is necessary to evaluate small (< or =4 mm) noncalcified nodules (NCN) in patients with no history of malignancy or acute lung disease.
  • MATERIALS AND METHODS: We reviewed serial thoracic helical CT scans between 1999-2000 obtained for the evaluation or follow-up imaging of small NCNs.
  • Patients were excluded if they had a history of neoplasm, infection, pulmonary fibrosis, or immune deficiency; also excluded if nodule(s) > or =5 mm at intake, or no follow-up scan within 1 year.
  • One patient had a 19 mm benign hamartoma that grew in 9 months.
  • CONCLUSION: The chance of growth in < or =4 mm NCNs in a 3- to 6-month period in patients with no previous history of malignancy or immune disorder is small; therefore, short-term follow-up imaging (<12 month) for nodules < or =4 mm is not necessary.

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  • (PMID = 15729116.001).
  • [ISSN] 0883-5993
  • [Journal-full-title] Journal of thoracic imaging
  • [ISO-abbreviation] J Thorac Imaging
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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69. Yoon HE, Fukuhara K, Michiura T, Takada M, Imakita M, Nonaka K, Iwase K: Pulmonary nodules 10 mm or less in diameter with ground-glass opacity component detected by high-resolution computed tomography have a high possibility of malignancy. Jpn J Thorac Cardiovasc Surg; 2005 Jan;53(1):22-8
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  • OBJECTIVES: For the histological diagnosis of small lung cancers of 10 mm or less in diameter (< or =10), resection by video-assisted thoracic surgery (VATS) with computed tomography (CT)-guided marking is feasible.
  • RESULTS: The histology of all 94 nodules showed 52 primary lung cancers, 6 metastatic tumors, 5 benign tumors, 8 intrapulmonary lymph nodes, and 23 inflammatory nodules.
  • [MeSH-minor] Colorectal Neoplasms / diagnostic imaging. Colorectal Neoplasms / pathology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Patient Selection. Predictive Value of Tests. Retrospective Studies. Thoracic Surgery, Video-Assisted

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  • (PMID = 15724498.001).
  • [ISSN] 1344-4964
  • [Journal-full-title] The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi
  • [ISO-abbreviation] Jpn. J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Japan
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70. Delgado-López PD, Martín-Velasco V, Castilla-Díez JM, Fernández-Arconada O, Corrales-García EM, Galacho-Harnero A, Rodríguez-Salazar A, Pérez-Mies B: Metastatic meningioma to the eleventh dorsal vertebral body: total en bloc spondylectomy. Case report and review of the literature. Neurocirugia (Astur); 2006 Jun;17(3):240-9
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  • CASE REPORT: In March 1996, a 37 year-old male underwent surgical resection for a left occipital intraventricular benign meningioma (WHO I).
  • Workup studies failed to reveal any primary tumor.
  • Definite pathology: benign meningioma (WHO I).
  • DISCUSSION: Distant metastases from intracranial meningiomas are rare entities, arising from benign lesions in, at least, 60% of cases.
  • Enam et al proposed a specific pathological score to differentiate benign, atypic and malignant meningiomas.
  • Hematogenous (especially venous; Batson's perivertebral plexus), linfatic and cerebrospinal fluid are the main routes involved in the spreading of the tumor.
  • [MeSH-major] Meningioma / pathology. Orthopedic Procedures / methods. Spinal Neoplasms / secondary. Spinal Neoplasms / surgery. Thoracic Vertebrae
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Review Literature as Topic

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  • (PMID = 16855782.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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71. Martínez Martínez P, Moldes Rodríguez M, Moreno Mata N, Simón Adiego C, Cebollero Presmanes M, González Aragoneses F: [Immunohistochemistry and surgical approaches in solitary fibrous tumor of the pleura]. Cir Esp; 2007 Mar;81(3):155-8
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  • [Title] [Immunohistochemistry and surgical approaches in solitary fibrous tumor of the pleura].
  • [Transliterated title] Inmunohistoquímica y vías de abordaje en el tumor fibroso pleural.
  • Solitary fibrous tumor of the pleura (SFTP) is a rare, benign, slow-growing neoplasm that arises from the submesothelial cells of the pleura.
  • Usually, resection of the tumor and adjacent structures are sufficient for resolution.
  • Because of the malignant potential of this tumor, long-term follow-up is mandatory.
  • [MeSH-major] Neoplasms, Fibrous Tissue / immunology. Neoplasms, Fibrous Tissue / surgery. Pleural Neoplasms / immunology. Pleural Neoplasms / surgery. Thoracic Surgery, Video-Assisted / instrumentation

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  • (PMID = 17349242.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antigens, CD34
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72. Ferrari G, Paci M, Sgarbi G: Thymolipoma of the anterior mediastinum: videothoracoscopic removal using a bilateral approach. Thorac Cardiovasc Surg; 2006 Sep;54(6):435-7
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  • Thymolipoma, a rare benign neoplasm of the anterior mediastinum, is often asymptomatic and as a result it can become quite large before it is diagnosed.
  • We describe the case of a young woman who presented with a fatty neoplasm of the anterior mediastinum.
  • [MeSH-major] Lipoma / surgery. Mediastinal Neoplasms / surgery. Thoracic Surgery, Video-Assisted. Thymus Neoplasms / surgery

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  • (PMID = 16967386.001).
  • [ISSN] 0171-6425
  • [Journal-full-title] The Thoracic and cardiovascular surgeon
  • [ISO-abbreviation] Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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73. Al-Daraji WI: Granular perineurioma: the first report of a rare distinctive subtype of perineurioma. Am J Dermatopathol; 2008 Apr;30(2):163-8
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  • Perineurioma represents a relatively recently described neoplasm in the spectrum of benign peripheral nerve sheath tumors composed of perineurial cells staining immunohistochemically positive for epithelial membrane antigen.
  • Interestingly, the granular component of this large tumor (4.5 cm in maximum diameter) was negative for S100, but positive for NKI-C3.
  • The morphology, immunohistochemistry, and the clinical behavior for this tumor and the differential diagnoses are discussed.
  • [MeSH-minor] Adult. Biopsy, Needle. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Rare Diseases. Risk Assessment. Thoracic Wall

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  • [CommentIn] Am J Dermatopathol. 2008 Dec;30(6):636 [19033949.001]
  • (PMID = 18360122.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Georghiou GP, Vidne BA, Sahar G, Sharoni E, Fuks A, Porat E: Primary cardiac valve tumors. Asian Cardiovasc Thorac Ann; 2010 Jun;18(3):226-8
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  • In one patient, the diagnosis of cardiac valve tumor was made incidentally on transesophageal echocardiography during aortocoronary bypass surgery.
  • Four of the 7 tumors were benign, and 3 were malignant.
  • Two patients with malignant tumors were considered unsuitable for adjuvant therapy by the oncologist; both died during follow-up from local tumor recurrence.
  • Excellent early and midterm surgical results can be obtained in patients with benign cardiac valve tumors, but the prognosis for those with a malignant tumor is poor.
  • [MeSH-minor] Aged. Cardiac Surgical Procedures. Echocardiography, Transesophageal. Exercise Tolerance. Female. Humans. Immunohistochemistry. Israel / epidemiology. Male. Microscopy, Electron, Transmission. Middle Aged. Neoplasm Recurrence, Local. Prevalence. Recovery of Function. Time Factors. Treatment Outcome

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  • (PMID = 20519288.001).
  • [ISSN] 1816-5370
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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75. Okagawa T, Uchida T, Suyama M: Thymoma with spontaneous regression and disappearance of pleural effusion. Gen Thorac Cardiovasc Surg; 2007 Dec;55(12):515-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chest radiography and computed tomography (CT) on admission showed an anterior mediastinal tumor with left pleural effusion, which was diagnosed as an inoperable malignant mediastinal tumor.
  • However, 3 weeks after admission CT showed that the tumor was diminishing and the pleural effusion had disappeared without any treatment.
  • A biopsy during video-assisted thoracic surgery was then performed.
  • The intraoperative finding showed that the tumor was round, well mobilized, and did not invade adjacent structures.
  • It was then assumed to be a benign teratoma that had been ruptured into the thoracic cavity.
  • Two months later, total thymectomy was performed through a median sternotomy because the tumor was pathologically diagnosed as a thymoma.
  • [MeSH-major] Mediastinal Neoplasms / pathology. Neoplasm Regression, Spontaneous. Pleural Effusion, Malignant / etiology. Thymoma / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy, Needle. Cautery. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Necrosis. Thoracic Surgery, Video-Assisted. Thoracotomy. Thymectomy. Tomography, X-Ray Computed

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  • [Cites] Am J Surg Pathol. 2001 Aug;25(8):1086-90 [11474295.001]
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  • (PMID = 18066646.001).
  • [ISSN] 1863-6705
  • [Journal-full-title] General thoracic and cardiovascular surgery
  • [ISO-abbreviation] Gen Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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76. Veronesi G, Bellomi M, Mulshine JL, Pelosi G, Scanagatta P, Paganelli G, Maisonneuve P, Preda L, Leo F, Bertolotti R, Solli P, Spaggiari L: Lung cancer screening with low-dose computed tomography: a non-invasive diagnostic protocol for baseline lung nodules. Lung Cancer; 2008 Sep;61(3):340-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In 15 of 104 (14%) invasive diagnostic procedures, the lesion was benign.
  • [MeSH-minor] Aged. Chi-Square Distribution. Contrast Media. Disease Progression. Female. Fluorodeoxyglucose F18. Humans. Incidence. Male. Mass Screening / methods. Middle Aged. Neoplasm Staging. Positron-Emission Tomography / methods. Prospective Studies. Radiation Dosage. Radiographic Image Interpretation, Computer-Assisted. Radiopharmaceuticals. Sensitivity and Specificity. Statistics, Nonparametric

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  • (PMID = 18308420.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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77. Mansour Z, Neuville A, Massard G: Mediastinal epithelioid haemangioendothelioma: a rare mediastinal tumour. Interact Cardiovasc Thorac Surg; 2010 Jan;10(1):122-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mediastinal epithelioid haemangioendothelioma: a rare mediastinal tumour.
  • We report the case of a 35-year-old patient with an incidental finding of an asymptomatic large (9.5 cm in diameter) anterior mediastinal tumour.
  • Radiological findings favoured the diagnosis of a benign mediastinal teratoma.
  • During surgical resection, we found a tumour adhering to the surrounding tissues, and encompassing the innominate vein which was totally occluded.
  • Immunohistochemistry diagnosed a mediastinal 'epithelioid haemangioendothelioma', which is a tumour of vascular origin.
  • We believe that the tumour took origin from the innominate vein and invaded the anterior mediastinum.
  • [MeSH-minor] Adult. Diagnostic Errors. Humans. Immunohistochemistry. Incidental Findings. Male. Neoplasm Invasiveness. Sternotomy. Teratoma / diagnosis. Tomography, X-Ray Computed. Treatment Outcome. Vascular Surgical Procedures

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  • (PMID = 19833641.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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78. Sung SH, Chang JW, Kim J, Lee KS, Han J, Park SI: Solitary fibrous tumors of the pleura: surgical outcome and clinical course. Ann Thorac Surg; 2005 Jan;79(1):303-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: We conducted a retrospective review of the clinical records of patients who had undergone surgical resection for benign and malignant solitary fibrous tumors of the pleura during a 10-year period (1993 to 2003).
  • Forty-four cases (69.8%) were benign and 19 (30.2%) were malignant.
  • Symptomatic presentation and the impression of a nonpleural tumor by imaging study were found to be related to a malignant pathologic diagnosis.
  • [MeSH-major] Neoplasms, Fibrous Tissue / surgery. Pleural Neoplasms / surgery. Thoracic Surgery, Video-Assisted. Thoracotomy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Child. Child, Preschool. Female. Humans. Incidental Findings. Life Tables. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Sternum / surgery. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15620963.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 17
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79. Casanova Espinosa A, Cisneros Serrano C, Girón Moreno RM, Olivera MJ, Moreno Balsalobre R, Zamora García E: [Pleural empyema associated with endobronchial lipoma]. Arch Bronconeumol; 2005 Mar;41(3):172-4
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  • Bronchial benign tumors comprise fewer than 4% of pulmonary neoplasms.
  • Endobronchial lipoma is an extremely rare benign neoplasm accounting for only 0.1% to 0.5% of all lung tumors.
  • Clinical symptoms of lipoma depend on the location of the tumor, the severity of bronchial obstruction, and the functional and anatomical effects on the parenchyma distal to the obstruction.
  • Computed axial tomography usually reveals the adipose composition of the lipomatous tumor.
  • [MeSH-minor] Aged. Aged, 80 and over. Bronchoscopy. Community-Acquired Infections / complications. Haemophilus Infections / complications. Haemophilus influenzae. Humans. Laser Therapy. Male. Pneumonia / complications. Pulmonary Atelectasis / etiology. Radiography, Thoracic. Tomography, X-Ray Computed

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  • (PMID = 15766470.001).
  • [ISSN] 0300-2896
  • [Journal-full-title] Archivos de bronconeumología
  • [ISO-abbreviation] Arch. Bronconeumol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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80. Pass HI, Wali A, Tang N, Ivanova A, Ivanov S, Harbut M, Carbone M, Allard J: Soluble mesothelin-related peptide level elevation in mesothelioma serum and pleural effusions. Ann Thorac Surg; 2008 Jan;85(1):265-72; discussion 272
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  • METHODS: We evaluated SMRP in serum from MPM patients (n = 90), lung cancer patients (n = 170), age and tobacco-matched asbestos-exposed individuals (n = 66), and in MPM pleural effusions (n = 45), benign effusions (n = 30), and non-MPM effusions (n = 20) using the MesoMark enzyme-linked immunosorbent assay kit (Fujirebio Diagnostics, Malvern, PA).
  • The MPM pleural effusion SMRP was significantly higher than benign or other non-MPM pleural effusions (65.57 +/- 11.33 nM vs 27.46 +/- 11.25 nM [p = 0.003] and 18.99 +/- 7.48 nM [p = 0.044], respectively).
  • [MeSH-major] Biomarkers, Tumor / blood. Membrane Glycoproteins / blood. Mesothelioma / blood. Pleural Effusion, Malignant / blood. Pleural Neoplasms / blood
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Analysis of Variance. Area Under Curve. Asbestosis / blood. Asbestosis / complications. Asbestosis / mortality. Asbestosis / pathology. Case-Control Studies. Female. GPI-Linked Proteins. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Prognosis. ROC Curve. Retrospective Studies. Risk Assessment. Sensitivity and Specificity. Survival Analysis

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  • (PMID = 18154821.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / GPI-Linked Proteins; 0 / Membrane Glycoproteins; 0 / mesothelin
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81. Junming M, Cheng Y, Dong C, Jianru X, Xinghai Y, Quan H, Wei Z, Mesong Y, Dapeng F, Wen Y, Bin N, Lianshun J, Huimin L: Giant cell tumor of the cervical spine: a series of 22 cases and outcomes. Spine (Phila Pa 1976); 2008 Feb 1;33(3):280-8
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  • [Title] Giant cell tumor of the cervical spine: a series of 22 cases and outcomes.
  • STUDY DESIGN: A consecutive series of 22 giant cell tumor (GCTs) of the cervical spine which underwent surgical treatment was observed from 1990-2003.
  • Though surgical resection of GCT arising in the cervical spine is commonly regarded as a recommended treatment method, it is still a challenge to achieve satisfactory results, especially for the late or recurrent cases, and there are few large series of cases reported with long-term follow-up of this tumor that are found in special segments in the literature.
  • RESULTS: One patient with C1-C2 GCT (vertebral body and posterior element involvement) who received subtotal resection of the tumor showed aggravation of neurologic deficit and died shortly after the surgery.
  • As a kind of benign but local aggressive or low potential malignancy tumor, we should take an aggressive attitude to excise the tumor as much as possible while reserving the neural function as a precondition.
  • Unlike in the thoracic and lumbar spine, a strictly "en bloc" resection is often not a feasible option because of the involvement of critical neurovascular structures.
  • [MeSH-major] Bone Neoplasms / surgery. Cervical Vertebrae / surgery. Giant Cell Tumor of Bone / surgery. Spinal Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Diskectomy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / mortality. Neoplasm Staging. Postoperative Complications. Spinal Fusion. Survival Rate. Treatment Outcome


82. Sakurai H, Kaji M, Mukai K, Suemasu K: Ectopic hamartomatous thymoma--a truly rare neoplasm: report of a case. Surg Today; 2010;40(2):146-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ectopic hamartomatous thymoma--a truly rare neoplasm: report of a case.
  • An ectopic hamartomatous thymoma is an extremely rare benign neoplasm that commonly occurs in the lower neck region.

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  • (PMID = 20107954.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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83. Economidou F, Tzortzaki EG, Schiza S, Antoniou KM, Neofytou E, Zervou M, Lambiri I, Siafakas NM: Microsatellite DNA analysis does not distinguish malignant from benign pleural effusions. Oncol Rep; 2007 Dec;18(6):1507-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microsatellite DNA analysis does not distinguish malignant from benign pleural effusions.
  • Distinguishing malignant from benign pleural effusions using routine cytology is a common diagnostic problem.
  • The control group consisted of 22 patients with benign pleural effusions.
  • Only 14 malignancy-associated pleural effusions were cytology-positive for malignant cells (54%), whereas all benign pleural effusions were negative.
  • One out of 22 (4.5%) patients with benign pleural effusion showed LOH in marker D3S134.
  • In conclusion, genetic alterations at the level of microsatellite DNA, were detected only in very few cases of malignant pleural effusions, and in one case of benign pleural effusion.
  • [MeSH-major] DNA / genetics. DNA, Neoplasm / genetics. Microsatellite Repeats. Pleural Effusion / physiopathology. Pleural Neoplasms / physiopathology
  • [MeSH-minor] Aged. Aged, 80 and over. Chromosome Mapping. Chromosomes, Human. Female. Genomic Instability. Humans. L-Lactate Dehydrogenase / analysis. Male. Middle Aged. Neoplasm Proteins / analysis. Proteins / analysis

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  • (PMID = 17982637.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Neoplasm Proteins; 0 / Proteins; 9007-49-2 / DNA; EC 1.1.1.27 / L-Lactate Dehydrogenase
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84. Crabtree KL, Arnold PM: Spinal seeding of a pilocytic astrocytoma in an adult, initially diagnosed 18 years previously. Pediatr Neurosurg; 2010;46(1):66-70
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  • Pilocytic astrocytoma (PA) is a slow-growing, well-circumscribed grade I glioma generally considered benign, with a low recurrence rate and an excellent prognosis following complete surgical resection.
  • To our knowledge, this is the longest time reported from initial tumor resection of leptomeningeal dissemination to the distal spinal cord.
  • [MeSH-major] Astrocytoma / secondary. Brain Neoplasms / pathology. Meningeal Neoplasms / secondary. Neoplasm Seeding. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Adult. Biopsy. Child. Follow-Up Studies. Humans. Laminectomy. Lumbar Vertebrae. Magnetic Resonance Imaging. Male. Thoracic Vertebrae. Time Factors

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20516744.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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85. Meyers BF, Haddad F, Siegel BA, Zoole JB, Battafarano RJ, Veeramachaneni N, Cooper JD, Patterson GA: Cost-effectiveness of routine mediastinoscopy in computed tomography- and positron emission tomography-screened patients with stage I lung cancer. J Thorac Cardiovasc Surg; 2006 Apr;131(4):822-9; discussion 822-9
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  • METHODS: We retrospectively reviewed our thoracic surgery database for cases between May 1999 and May 2004.
  • A decision model was created using TreeAgePro software and our observed data for the prevalence of mediastinal lymph node metastases and for the rate of benign nodules.
  • Benign nodules were found in 19/248 (8%) of patients.
  • [MeSH-minor] Bromhexine. Chemotherapy, Adjuvant. Cost-Benefit Analysis. Disease Progression. Humans. Lymphatic Metastasis. Missouri. Neoplasm Staging. Positron-Emission Tomography. Quality-Adjusted Life Years. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 16580440.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] Q1J152VB1P / Bromhexine
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86. Wang XT, Sienel W, Eggeling S, Ludwig C, Stoelben E, Mueller J, Klein CA, Passlick B: Detection of disseminated tumor cells in mediastinoscopic lymph node biopsies and lymphadenectomy specimens of patients with NSCLC by quantitative RT-PCR. Eur J Cardiothorac Surg; 2005 Jul;28(1):26-32
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  • [Title] Detection of disseminated tumor cells in mediastinoscopic lymph node biopsies and lymphadenectomy specimens of patients with NSCLC by quantitative RT-PCR.
  • OBJECTIVE: Detection of disseminated tumor cells in mediastinoscopic biopsies could improve staging and might be helpful concerning indications for neoadjuvant therapy regimens.
  • This prospective study was performed to evaluate a simple and observer-independent polymerase chain reaction (PCR)-based method for the detection of disseminated tumor cells in regional lymph nodes.
  • qRT-PCR amplification of cytokeratin 19 (CK19) transcripts was applied for the detection of tumor cell-specific RNA.
  • We differentiated between illegitimate marker gene transcription and cancer-specific expression by using a cut-off value that was obtained from the analysis of 18 lymph nodes of patients with benign lung diseases.
  • RESULTS: Ninety-four (94%) lymph nodes were tumor-free by histopathology. qRT-PCR detected disseminated tumor cells in 26 (28%) of these lymph nodes.
  • All of the remaining six lymph nodes that were judged by the pathologist to contain tumor cells exhibited CK19 transcripts.
  • Twenty-three patients had a pN0 status. qRT-PCR detected disseminated tumor cells in 13 (56%) of these pN0 patients.
  • The mediastinoscopic biopsies showed disseminated tumor cells in four (21%) out of 19 histopathologically tumor-free samples.
  • CONCLUSIONS: CK19 qRT-PCR is a sensitive and specific tools for the detection of disseminated tumor cells in regional lymph nodes of patients with operable NSCLC.
  • [MeSH-minor] Aged. Biomarkers, Tumor / biosynthesis. Biomarkers, Tumor / genetics. Biopsy. Female. Humans. Keratins / biosynthesis. Keratins / genetics. Lymph Node Excision. Lymphatic Metastasis / pathology. Male. Mediastinoscopy. Mediastinum. Middle Aged. Neoplasm Staging. Prospective Studies. RNA, Neoplasm / genetics. Reverse Transcriptase Polymerase Chain Reaction / methods. Sensitivity and Specificity

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  • (PMID = 15939599.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Neoplasm; 68238-35-7 / Keratins
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87. Pedersen JH, Ashraf H, Dirksen A, Bach K, Hansen H, Toennesen P, Thorsen H, Brodersen J, Skov BG, Døssing M, Mortensen J, Richter K, Clementsen P, Seersholm N: The Danish randomized lung cancer CT screening trial--overall design and results of the prevalence round. J Thorac Oncol; 2009 May;4(5):608-14
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  • (1) Nodules smaller than 5 mm and calcified (benign) nodules were tabulated, (2) Noncalcified nodules between 5 and 15 mm were rescanned after 3 months.
  • Eleven of 17 lung cancers at baseline were treated surgically, eight of these by video assisted thoracic surgery resection.
  • [MeSH-minor] Adult. Aged. Denmark / epidemiology. Early Detection of Cancer. Epidemiologic Research Design. False Positive Reactions. Female. Humans. Male. Mass Screening. Middle Aged. Neoplasm Staging. Prevalence. Prognosis. Sensitivity and Specificity. Smoking / epidemiology

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  • [CommentIn] J Thorac Oncol. 2009 May;4(5):563-4 [19395908.001]
  • (PMID = 19357536.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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88. Thomas R, Sharma N, Burke C, Maxwell D, Howlett DC: Parotid incidentaloma detected during thoracic PET imaging: how should these lesions be managed? Br J Hosp Med (Lond); 2010 May;71(5):292-3
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  • [Title] Parotid incidentaloma detected during thoracic PET imaging: how should these lesions be managed?
  • Further investigation with ultrasound and core biopsy confirmed benign parotid neoplasm in all three cases.

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  • (PMID = 20448501.001).
  • [ISSN] 1750-8460
  • [Journal-full-title] British journal of hospital medicine (London, England : 2005)
  • [ISO-abbreviation] Br J Hosp Med (Lond)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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89. Furák J, Bács E, Grochulski R, Wolfárd A, Szoke T, Troján I, Csernay E, Lázár G: [Lobectomy performed through a video-assisted mini thoracotomy, as a new technique in our clinical practice]. Magy Seb; 2008 Feb;61(1):29-32
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  • The indications for surgery were the following: benign lesions in three cases, T1N0 squamous lung cancers proved by cytology in six patients, and another case, when the CT suggested - but cytologically not proved - T1N0 lung cancer.
  • The three benign lesions were hamartochondromas.
  • [MeSH-major] Lung Diseases / surgery. Pneumonectomy / methods. Thoracic Surgery, Video-Assisted
  • [MeSH-minor] Aged. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Chondroma / surgery. Female. Hamartoma / surgery. Humans. Lung Neoplasms / pathology. Lung Neoplasms / surgery. Male. Middle Aged. Neoplasm Staging. Retrospective Studies

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  • (PMID = 18296282.001).
  • [ISSN] 0025-0295
  • [Journal-full-title] Magyar sebészet
  • [ISO-abbreviation] Magy Seb
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
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90. Lemaire A, Nikolic I, Petersen T, Haney JC, Toloza EM, Harpole DH Jr, D'Amico TA, Burfeind WR: Nine-year single center experience with cervical mediastinoscopy: complications and false negative rate. Ann Thorac Surg; 2006 Oct;82(4):1185-9; discussion 1189-90
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  • Pathology included lung cancer (n = 1,459), metastatic disease (n = 78), lymphoma (n = 51), and other benign disease (n = 557).
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. False Negative Reactions. Female. Humans. Lymphatic Metastasis / diagnosis. Male. Middle Aged. Neck. Neoplasm Staging. Retrospective Studies

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  • (PMID = 16996905.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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91. Patriti A, Rondelli F, Gullà N, Donini A: Laparoscopic treatment of a solitary fibrous tumor of the greater omentum presenting as spontaneous haemoperitoneum. Ann Ital Chir; 2006 Jul-Aug;77(4):351-3
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  • [Title] Laparoscopic treatment of a solitary fibrous tumor of the greater omentum presenting as spontaneous haemoperitoneum.
  • CT examination confirmed the hypothesis of a vascular tumour.
  • The histological findings were diagnostic of a benign solitary fibrous tumor, an extremely rare neoplasm for a long time considered to be an exclusively thoracic lesion.
  • This is the first case of a solitary fibrous tumor presenting as haemoperitoneum and the first time it was removed laparoscopically.

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  • (PMID = 17139967.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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92. Chen G, Liu XY, Wang Z, Liu FY: Vascular endothelial growth factor C: the predicator of early recurrence in patients with N2 non-small-cell lung cancer. Eur J Cardiothorac Surg; 2010 Mar;37(3):546-51
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  • METHODS: Cancer tissue samples from 92 patients with pN2 non-small-cell lung cancer and benign lung disease tissues samples from 30 patients were examined by reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry assays to detect VEGF-C expression.
  • All patients with N2 disease were evaluated within 1 year after surgery to detect early tumour recurrence.
  • RESULTS: VEGF-C mRNA expression was observed in 64 (70%) pN2 lung cancer tissues, but was not found in benign lung disease tissues.
  • [MeSH-major] Biomarkers, Tumor / biosynthesis. Carcinoma, Non-Small-Cell Lung / metabolism. Lung Neoplasms / metabolism. Vascular Endothelial Growth Factor C / biosynthesis
  • [MeSH-minor] Adult. Aged. Brain Neoplasms / secondary. Chemotherapy, Adjuvant. Epidemiologic Methods. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. RNA, Messenger / genetics. RNA, Neoplasm / genetics. Radiotherapy, Adjuvant. Reverse Transcriptase Polymerase Chain Reaction / methods

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  • [Copyright] Copyright (c) 2009 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
  • (PMID = 19758816.001).
  • [ISSN] 1873-734X
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / VEGFC protein, human; 0 / Vascular Endothelial Growth Factor C
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93. Huang TH, Wang Z, Li Q, Li FR, Qi H, Zhou HX: [Clinical significance of enrichment and detection of circulating tumor cells in NSCLC patients with immunomagnetic beads]. Zhonghua Zhong Liu Za Zhi; 2007 Sep;29(9):676-80
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  • [Title] [Clinical significance of enrichment and detection of circulating tumor cells in NSCLC patients with immunomagnetic beads].
  • OBJECTIVE: To investigate the feasibility and clinical significance of detection of circulating tumor cells (CTCs) in peripheral blood of NSCLC patients by lung cancer cell immunomagnetic enrichment and detection kit.
  • METHODS: Four groups of patients (Group A: 18 cases with stage I lung cancer; Group B: 33 cases with stage II - IV lung cancer; Group C: 20 cases with benign pulmonary diseases; Group D: 20 healthy volunteers) were enrolled for detection of CTCs using the lung cancer cell enrichment and detection kit developed by ourselves, and compared with the results obtained using simple ICC method and the detection of CK19 mRNA and LUNX mRNA using nested PCR as control.
  • It may be helpful in diagnosis of NSCLC micrometastasis and circulating tumor cells in peripheral blood, re-determination of clinical stage and provide important information for cancer-therapy personalization.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adult. Aged. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Female. Humans. Male. Middle Aged. Neoplasm Staging. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 18246797.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / BPIFA1 protein, human; 0 / Glycoproteins; 0 / Keratin-19; 0 / Phosphoproteins; 0 / RNA, Messenger
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94. Kanauchi N, Oizumi H, Honma T, Kato H, Endo M, Suzuki J, Fukaya K, Sadahiro M: Role of diffusion-weighted magnetic resonance imaging for predicting of tumor invasiveness for clinical stage IA non-small cell lung cancer. Eur J Cardiothorac Surg; 2009 Apr;35(4):706-10; discussion 710-1
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  • [Title] Role of diffusion-weighted magnetic resonance imaging for predicting of tumor invasiveness for clinical stage IA non-small cell lung cancer.
  • Favorable results have been reported using this imaging system to differentiate between benign and malignant lesions in some organs, and to correlate with the degree of cell differentiation in lung cancer.
  • The purpose of this study was to assess the role of DWI for predicting tumor invasiveness of non-small cell lung cancers (NSCLC), especially for clinical stage IA patients.
  • We analyzed the associations between the pathological findings and the following preoperative clinical factors: age, gender, smoking history, preoperative CEA levels (<5.0 or >/=5.0ng/ml), preoperative tumor size, SUV max on PET/CT (<5.0 or >/=5.0) and DWI (positive or negative).
  • Multivariate analysis showed that DWI (p=0.005) was an independent predictive factor for tumor invasiveness.
  • CONCLUSION: Our results suggest that DWI might be a useful method for predicting tumor invasiveness for clinical stage IA NSCLC.
  • [MeSH-minor] Aged. Aged, 80 and over. Cell Differentiation. Diffusion Magnetic Resonance Imaging. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Predictive Value of Tests. Prognosis

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  • (PMID = 19216085.001).
  • [ISSN] 1873-734X
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
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95. Solli P, Spaggiari L: Indications and developments of video-assisted thoracic surgery in the treatment of lung cancer. Oncologist; 2007 Oct;12(10):1205-14
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  • [Title] Indications and developments of video-assisted thoracic surgery in the treatment of lung cancer.
  • The term video-assisted thoracic surgery (VATS) is used to describe a modern minimally invasive surgical technique that nowadays represents a valid alternative to open procedures (i.e., thoracotomy) for many chest diseases.
  • The VATS approach is presently used in many intrathoracic disorders, but while well established in benign chest disease, its role continues to evolve regarding the management of lung cancer.
  • [MeSH-major] Lung Neoplasms / surgery. Thoracic Surgery, Video-Assisted
  • [MeSH-minor] Humans. Minimally Invasive Surgical Procedures. Neoplasm Staging. Patient Care Planning. Prognosis

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  • (PMID = 17962614.001).
  • [ISSN] 1083-7159
  • [Journal-full-title] The oncologist
  • [ISO-abbreviation] Oncologist
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 105
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96. Hsu PK, Hsu HS, Lee HC, Hsieh CC, Wu YC, Wang LS, Huang BS, Hsu WH, Huang MH: Management of primary chest wall tumors: 14 years' clinical experience. J Chin Med Assoc; 2006 Aug;69(8):377-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Primary chest wall tumor is rare but it encompasses tumors of various origins.
  • Malignant and benign tumors were equally distributed.
  • Nine of 31 patients (29.0%) with benign chest wall tumors were free of symptoms whereas patients with malignant chest wall tumors were all symptomatic (p = 0.002).
  • Patients with malignant chest wall tumors were older than those with benign tumors (p < 0.001).
  • The mean largest diameter of tumors was also larger in malignant tumors than in benign tumors (p = 0.04).
  • CONCLUSION: Patients with primary malignant chest wall neoplasm were older than those with benign tumors.
  • The mean size of malignant tumors was larger than that of benign tumors.
  • [MeSH-major] Thoracic Neoplasms / therapy. Thoracic Wall

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  • (PMID = 16970274.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China (Republic : 1949- )
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97. Schaller B: Spinal meningioma: relationship between histological subtypes and surgical outcome? J Neurooncol; 2005 Nov;75(2):157-61
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  • Intraspinal meningiomas are slow growing benign tumors that produce indolent neurological deficits, which are often reversible following operation.
  • Spinal meningiomas were of high-cervical location in 9 (27%) and of low-cervico-thoracic location in 24 (73%) patients.
  • Tumor position was laterally in 19 (58%), posteriorly in 8 (24%) and anteriorly in 6 (18%) patients.
  • Following tumor resection, neurological deficits resolved in 26 of 33 patients (79%) and worsened in 7 of 33 patients (21%) all of the latter had meningiomas of the psammomatous type.
  • Posterior or lateral tumor position in the spinal canal, location below C4, age less than 60 years, and duration of preoperative symptoms seem to be correlated with a good outcome.
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Angiography. Chi-Square Distribution. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Myelography. Neoplasm Recurrence, Local. Neurologic Examination. Prognosis. Regression Analysis. Retrospective Studies. Sex Factors. Time Factors. Tomography, X-Ray Computed. Treatment Outcome. Tumor Burden. X-Rays

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  • (PMID = 16132511.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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98. Verdon F, Burnand B, Herzig L, Junod M, Pécoud A, Favrat B: Chest wall syndrome among primary care patients: a cohort study. BMC Fam Pract; 2007;8:51
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  • CWS coexisted with coronary disease in 19 and neoplasm in 6.
  • CONCLUSION: CWS is common and benign, but leads to anxiety and recurred frequently.
  • [MeSH-major] Chest Pain / epidemiology. Family Practice / statistics & numerical data. Private Practice / utilization. Thoracic Wall / physiopathology

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  • (PMID = 17850647.001).
  • [ISSN] 1471-2296
  • [Journal-full-title] BMC family practice
  • [ISO-abbreviation] BMC Fam Pract
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2072948
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99. Zhang XM, Shen CY, Li W, Zhang XM: [Surgical treatment of tumor invading important vessel]. Zhonghua Wai Ke Za Zhi; 2007 Aug 1;45(15):1044-7
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  • [Title] [Surgical treatment of tumor invading important vessel].
  • OBJECTIVE: To sum up preliminary experience of successful resection of tumor involving important vessel in 77 cases.
  • The tumor involving thoraco-abdominal cavity was in one case with malignant neuroblastoma.
  • The tumor from retro-peritoneum invaded into the whole inferior vena cava (IVC), and into two-thirds of the right atrium.
  • Tumor located in thoracic cavity were in 13 cases including IVC leiomyosarcoma in 2 cases, thymic carcinoma in 3 cases, malignant thymoma in 4 cases, malignant seminoma of superior mediastinum in 1 case, malignant lymphoma in 1 case, lung cancer in 2 cases.
  • The tumor located in abdominal cavity were in 24 cases including renal carcinoma with tumor thrombi in 11 cases, inflammatory pseudotumor of retro-peritoneum in 4 cases, malignant fibrous histiocytoma of retro-peritoneum in 1 case, non-Hodgkin's disease of retro-peritoneum in 1 case, lymph metastasis of retro-peritoneum in 2 cases, paraganglion tumor of the right adrenal gland in 1 case, ampullary carcinoma in 1 case, leiomyosarcoma of abdominal IVC in 1 case, leiomyosarcoma of pelvic cavity and IVC in 1 cases, fibrosarcoma of pelvic cavity in 1 case.
  • Tumor located in four extremities in 6 cases including osteogenic sarcoma in 3 cases, vascular endotheliosarcoma of the left iliac fossa in 1 case, neurofibroma of the left upper extremity in 1 case, lymphoma of double groin in 1 case.
  • Tumor located in neck in 33 cases including carotid body tumor in 32 cases and neurofibroma of the left upper extremity in 1 case.
  • RESULTS: Complete resection of tumor was in 72 cases, with a rate of 93.5%, palliative resection of tumor was in 5 cases with a rate of 6.5%.
  • Temporary shunt of carotid artery for neck tumor was used in 18 cases.
  • No death occurred for benign tumor.
  • CONCLUSION: The radical resection rate for tumor involving important vessel may be improved with the help of vascular technique.
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Invasiveness. Retrospective Studies. Treatment Outcome. Vena Cava, Inferior / pathology. Vena Cava, Inferior / surgery

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  • (PMID = 18005586.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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100. Alipour S, Mood NI: Intracystic breast carcinoma: case study and review. Del Med J; 2010 Dec;82(12):441-3
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  • While cystic breast disease is the most frequent cause of benign breast masses, intracystic breast cancers are rare.
  • [MeSH-minor] Biopsy. Breast / pathology. Carcinoma in Situ / pathology. Carcinoma, Ductal, Breast / pathology. Carcinoma, Papillary / pathology. Drainage. Female. Humans. Lymphatic Metastasis / pathology. Mammography. Mastectomy, Modified Radical. Middle Aged. Neoplasm Staging. Neoplasm, Residual / pathology. Radiography, Thoracic. Wound Healing

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  • (PMID = 21323091.001).
  • [ISSN] 0011-7781
  • [Journal-full-title] Delaware medical journal
  • [ISO-abbreviation] Del Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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