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1. Moore BC, Hamlin HJ, Botteri NL, Lawler AN, Mathavan KK, Guillette LJ Jr: Posthatching development of Alligator mississippiensis ovary and testis. J Morphol; 2010 May;271(5):580-95
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  • [Title] Posthatching development of Alligator mississippiensis ovary and testis.
  • We investigated ovary and testis development of Alligator mississippiensis during the first 5 months posthatch.
  • We found profound morphological changes in both ovary and testis.
  • During this same period, testicular germ cells found along the tubule margins were observed progressing from spermatogonia to round spermatids located within the center of tubules.
  • Accompanying this meiotic development, interstitial Leydig cell clusters become more visible and testicular capsules thickened.
  • During the observed testis development, the thickening tunica albuginea and widening interstitial tissues showed increasing PAS- and PAMS reactivity.
  • We observed putative intersex structures in both ovary and testis.
  • On the coelomic aspect of testes were cell clusters with germ cell morphology and at the posterior end of ovaries, we observed "medullary rests" resembling immature testis cords.

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
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  • (PMID = 20013789.001).
  • [ISSN] 1097-4687
  • [Journal-full-title] Journal of morphology
  • [ISO-abbreviation] J. Morphol.
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / R21 ES014053; United States / NICHD NIH HHS / HD / R21 HD047885; United States / NIEHS NIH HHS / ES / R21 ES014053-01A1; United States / NIEHS NIH HHS / ES / R21 ES014053-01; United States / Howard Hughes Medical Institute / / ; United States / NICHD NIH HHS / HD / R21 HD047885-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS154410; NLM/ PMC2851832
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2. Zamoner A, Barreto KP, Filho DW, Sell F, Woehl VM, Guma FC, Pessoa-Pureur R, Silva FR: Propylthiouracil-induced congenital hypothyroidism upregulates vimentin phosphorylation and depletes antioxidant defenses in immature rat testis. J Mol Endocrinol; 2008 Mar;40(3):125-35
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  • [Title] Propylthiouracil-induced congenital hypothyroidism upregulates vimentin phosphorylation and depletes antioxidant defenses in immature rat testis.
  • These alterations in intermediate filament dynamics could result in loss of Sertoli cell cytoskeletal integrity and be somewhat related to the deleterious effects of hypothyroidism in testis.
  • Moreover, we observed decreased oxygen consumption and unaltered lipid peroxidation in hypothyroid testis.
  • However, we demonstrated decreased enzymatic and non-enzymatic antioxidant defenses, supporting an increased mitochondrial reactive oxygen species (ROS) generation, contributing to biochemical changes in hypothyroid testis.
  • In addition, the changes in the testis histoarchitecture could be ascribed to cytoskeletal alterations, decreased antioxidant defenses, and increased ROS generation, leading to oxidative stress in the organ.
  • [MeSH-major] Antioxidants / metabolism. Congenital Hypothyroidism / metabolism. Propylthiouracil. Testis / metabolism. Vimentin / metabolism

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  • (PMID = 18316471.001).
  • [ISSN] 1479-6813
  • [Journal-full-title] Journal of molecular endocrinology
  • [ISO-abbreviation] J. Mol. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Reactive Oxygen Species; 0 / Vimentin; 721M9407IY / Propylthiouracil; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases
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3. Gupta Y, Kohli DV, Jain SK: Vitamin B12-mediated transport: a potential tool for tumor targeting of antineoplastic drugs and imaging agents. Crit Rev Ther Drug Carrier Syst; 2008;25(4):347-79
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  • [Title] Vitamin B12-mediated transport: a potential tool for tumor targeting of antineoplastic drugs and imaging agents.
  • The receptor for vitamin B12 is overexpressed on a number of human tumors, including cancers of the ovary, kidney, uterus, testis, brain, colon, lung, and myelocytic blood cells.
  • This review reflects the potentiality of vitamin B12 for tumor targeting of chemotherapeutic and diagnostic agents.

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  • (PMID = 18540842.001).
  • [ISSN] 0743-4863
  • [Journal-full-title] Critical reviews in therapeutic drug carrier systems
  • [ISO-abbreviation] Crit Rev Ther Drug Carrier Syst
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antineoplastic Agents; 0 / Contrast Media; 0 / Drug Carriers; 0 / Oligonucleotides, Antisense; 0 / Transcobalamins; P6YC3EG204 / Vitamin B 12; SML2Y3J35T / Colchicine
  • [Number-of-references] 153
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4. Vijayaraghavan S, Chakrabarti R, Myers K: Regulation of sperm function by protein phosphatase PP1gamma2. Soc Reprod Fertil Suppl; 2007;63:111-21
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  • The protein phosphatase isoform, PPlgamma2, with a unique C-terminus extension is highly enriched in spermatozoa and testis.

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  • (PMID = 17566266.001).
  • [ISSN] 1747-3403
  • [Journal-full-title] Society of Reproduction and Fertility supplement
  • [ISO-abbreviation] Soc Reprod Fertil Suppl
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / R0HD38520
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 14-3-3 Proteins; 0 / Chloride Channels; 0 / Contraceptive Agents, Male; 0 / PPP1R7 protein, human; EC 3.1.3.16 / Phosphoprotein Phosphatases; EC 3.1.3.16 / Protein Phosphatase 1
  • [Number-of-references] 64
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5. Manásková P, Peknicová J, Elzeinová F, Tichá M, Jonáková V: Origin, localization and binding abilities of boar DQH sperm surface protein tested by specific monoclonal antibodies. J Reprod Immunol; 2007 Jun;74(1-2):103-13
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  • The mRNA transcript of DQH protein was found in seminal vesicles and not in the testis, epididymis and prostate.

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  • (PMID = 17270277.001).
  • [ISSN] 0165-0378
  • [Journal-full-title] Journal of reproductive immunology
  • [ISO-abbreviation] J. Reprod. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / DQH sperm surface protein, Sus scrofa; 0 / Membrane Glycoproteins; 0 / Seminal Plasma Proteins
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6. Dawson PA, Pirlo KJ, Steane SE, Kunzelmann K, Chien YJ, Markovich D: Molecular cloning and characterization of the mouse Na+ sulfate cotransporter gene (Slc13a4): Structure and expression. Genes Genet Syst; 2006 Aug;81(4):265-72
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  • In this study, we identified a new mouse Na(+)-sulfate cotransporter (mNaS2), characterized its tissue distribution and determined its cDNA and gene (Slc13a4) structures. mNaS2 mRNA was expressed in placenta, brain, lung, eye, heart, testis, thymus and liver.

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  • (PMID = 17038798.001).
  • [ISSN] 1341-7568
  • [Journal-full-title] Genes & genetic systems
  • [ISO-abbreviation] Genes Genet. Syst.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anion Transport Proteins; 0 / DNA, Complementary; 0 / RNA, Messenger; 0 / SLC13A4 protein, human; 0 / Slc13a4 protein, mouse; 0 / Symporters
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7. Burrello N, Vicari E, Calogero AE: Chromosome abnormalities in spermatozoa of patients with azoospermia and normal somatic karyotype. Cytogenet Genome Res; 2005;111(3-4):363-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Since epididymal and testicular spermatozoa of azoospermic patients are frequently used for intracytoplasmic sperm injection (ICSI), many studies have been carried out to evaluate their karyotype.
  • In most of the studies, spermatozoa have been retrieved from the testis or the epididymis of patients with nonobstructive (NOA) or obstructive (OA) azoospermia, respectively.

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  • [Copyright] Copyright 2005 S. Karger AG, Basel.
  • (PMID = 16192717.001).
  • [ISSN] 1424-859X
  • [Journal-full-title] Cytogenetic and genome research
  • [ISO-abbreviation] Cytogenet. Genome Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 18
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8. Arenas-Ríos E, León-Galván MA, Mercado PE, López-Wilchis R, Cervantes DL, Rosado A: Superoxide dismutase, catalase, and glutathione peroxidase in the testis of the Mexican big-eared bat (Corynorhinus mexicanus) during its annual reproductive cycle. Comp Biochem Physiol A Mol Integr Physiol; 2007 Sep;148(1):150-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Superoxide dismutase, catalase, and glutathione peroxidase in the testis of the Mexican big-eared bat (Corynorhinus mexicanus) during its annual reproductive cycle.
  • Testis recrudescence begins in May-June, peaks in August and then undergoes a profound involution being totally regressed in November.
  • SOD total activity is very low from October to February; increases sharply one full month before testes recrudescence starts, and in August, when testis activity was at its peak, SOD is 3-4 times lower than in July.
  • The main peak of activity occurs during testicular recrudescence with an additional smaller peak, two months before the onset of recrudescence.
  • Glutathione peroxidase total activity parallels almost exactly the testis growth cycle, increases in July, reaches a peak in August and decreases through September to almost disappear in October.
  • SOD specific activity shows a pre-testicular increase of activity, maintains its activity from March to July and then descends drastically to almost nil in August, maintaining these low values until February.
  • Catalase specific activity is particularly important during the period of testicular regression.
  • GPX specific activity is low from March to July, months of testicular recrudescence; whereas its activity increases in August and peaks in November, when testes regression occurs.
  • [MeSH-major] Catalase / metabolism. Chiroptera / physiology. Glutathione Peroxidase / metabolism. Reproduction. Superoxide Dismutase / metabolism. Testis / enzymology

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  • (PMID = 17481934.001).
  • [ISSN] 1095-6433
  • [Journal-full-title] Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
  • [ISO-abbreviation] Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.11.1.6 / Catalase; EC 1.11.1.9 / Glutathione Peroxidase; EC 1.15.1.1 / Superoxide Dismutase
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9. Tang B, Hu W, Hao J, Zhu Z: Developmental expression of steroidogenic factor-1, cyp19a1a and cyp19a1b from common carp (Cyprinus carpio). Gen Comp Endocrinol; 2010 Jul 1;167(3):408-16
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  • Cyp19a1b was preferentially expressed in the brain of both sexes but also was present at much lower levels in testis, ovary and kidney (females only).
  • Although cyp19a1a expression was preferentially expressed in ovaries, it was also present at much lower levels in brain, testis, kidney and spleen (males only).
  • These developmental expression patterns in carp gonads suggest important roles of SF-1 and cyp19a1b in testis development and of cyp19a1a in ovary development.

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  • [Copyright] (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20338172.001).
  • [ISSN] 1095-6840
  • [Journal-full-title] General and comparative endocrinology
  • [ISO-abbreviation] Gen. Comp. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / Isoenzymes; 0 / Steroidogenic Factor 1; EC 1.14.14.1 / Aromatase
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10. Del Rocío Estrada-Sánchez G, Altamirano-Ley J, Ochoa-Carrillo FJ: [Normal variants and frequent pitfalls with (18)FDG PET/CT study]. Cir Cir; 2007 Nov-Dec;75(6):491-7
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  • 3) adipocytes, ovaries, testis;.
  • 5) breast, small intestine, testis, kidney, erythrocytes;.
  • 8) testis, brain;.

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  • (PMID = 18177573.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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11. El Gohary MA: Failure of fusion of epididymis and testis: a rare laparoscopic finding. Eur J Pediatr Surg; 2009 Apr;19(2):108-9
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  • [Title] Failure of fusion of epididymis and testis: a rare laparoscopic finding.
  • A case of complete separation between an abdominal testis and the epididymis discovered during diagnostic laparoscopy for impalpable testis is presented.
  • A 13-year-old boy with impalpable testis underwent diagnostic laparoscopy for impalpable testis.
  • The vas on the left side was seen entering a closed internal ring while a small testis was found completely separated and medial to the internal ring.
  • [MeSH-major] Cryptorchidism / diagnosis. Cryptorchidism / surgery. Epididymis / abnormalities. Laparoscopy. Testis / abnormalities

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  • (PMID = 19199233.001).
  • [ISSN] 1439-359X
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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12. Wang H, Zhang P, Wang CT: [Analysis of expression pattern of a novel testis-highly expressed gene Biot2-L and the primary study on its role in testis development]. Sichuan Da Xue Xue Bao Yi Xue Ban; 2009 Sep;40(5):853-6
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  • [Title] [Analysis of expression pattern of a novel testis-highly expressed gene Biot2-L and the primary study on its role in testis development].
  • OBJECTIVE: To study on the expression pattern of a novel gene, Biot2-L, in mice and its primary bio-function on the development of testis.
  • The highly expression of Biot2-L in adult testis but low or absent expressed in other tissues was observed.
  • A regular change of Biot2-L expression level during the testis development and spermatogonia was demonstrated by the results of Real-time RT-PCR.
  • CONCLUSION: Biot2-L was highly expressed in adult testis and regular changed during the testis development, which suggested that the Biot2-L would be involved in the testis development and spermatogonia.
  • [MeSH-major] Antigens, Neoplasm / genetics. Testis / growth & development. Testis / metabolism

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  • (PMID = 19950598.001).
  • [ISSN] 1672-173X
  • [Journal-full-title] Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
  • [ISO-abbreviation] Sichuan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / 1700008F21Rik protein, mouse; 0 / Antigens, Neoplasm
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13. Acharya H, Mane SB, Dhende NP, Obeidah A: Use of the processes vaginalis: A new technique for reinforcing the neourethra in hypospadias associated with undescended testis. Indian J Urol; 2009 Jul;25(3):329-31
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  • [Title] Use of the processes vaginalis: A new technique for reinforcing the neourethra in hypospadias associated with undescended testis.
  • CONTEXT: The incidence of undescended testis (UDT) along with hypospadias varies from 6 to 31%.
  • AIMS: Simultaneous repair of hypospadias and undescended testis.
  • CONCLUSIONS: In patients of undescended testis with hypospadias, simultaneous repair with the processes vaginalis flap is an ideal technique with good results.

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  • [ISSN] 1998-3824
  • [Journal-full-title] Indian journal of urology : IJU : journal of the Urological Society of India
  • [ISO-abbreviation] Indian J Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2779954
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14. Hussein MR, Abu-Dief EE, Abou El-Ghait AT, Adly MA, Abdelraheem MH: Morphological evaluation of the radioprotective effects of melatonin against X-ray-induced early and acute testis damage in Albino rats: an animal model. Int J Exp Pathol; 2006 Jun;87(3):237-50
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  • [Title] Morphological evaluation of the radioprotective effects of melatonin against X-ray-induced early and acute testis damage in Albino rats: an animal model.
  • Our knowledge about radioprotective effects of melatonin against X-ray-induced testis damage is rudimentary.
  • In this investigation, we hypothesized that melatonin can minimize germ-cell depletion and morphological features of cell damage in testis following X-ray irradiation (XRI).
  • To examine these effects, and to test our hypothesis, an animal model comprised of 60 Albino rats was established.
  • Histologically, there were marked depletions (66%) of the germinal epithelial cells, in XRI group (Groups 2 and 3), whereas these changes were almost absent in XRI testis of animals pretreated with melatonin (Group 5).
  • The number of spermatogenic cells in XRI testis of animals pretreated with melatonin (Group 5) was comparable (95%) to that of non-irradiated group (Groups 1 and 4) but significantly (P < 0.05) higher than those in XRI testis (34%, Groups 2 and 3).
  • Ultrastructurally, XRI testis (Groups 2 and 3) showed features of apoptosis (condensation of the nuclei, vacuolization of the cytoplasm, increased cytoplasmic density and apoptotic bodies).
  • These features were absent in XRI testis of animals pretreated with melatonin (Group 5).
  • Administration of melatonin (MEL) prior to irradiation can protect testis against its destructive effects.
  • [MeSH-major] Melatonin / pharmacology. Models, Animal. Radiation-Protective Agents / pharmacology. Testis / radiation effects. X-Rays / adverse effects

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  • (PMID = 16709232.001).
  • [ISSN] 0959-9673
  • [Journal-full-title] International journal of experimental pathology
  • [ISO-abbreviation] Int J Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiation-Protective Agents; JL5DK93RCL / Melatonin
  • [Other-IDs] NLM/ PMC2517365
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15. Lui WY, Mruk DD, Cheng CY: Interactions among IQGAP1, Cdc42, and the cadherin/catenin protein complex regulate Sertoli-germ cell adherens junction dynamics in the testis. J Cell Physiol; 2005 Jan;202(1):49-66
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  • [Title] Interactions among IQGAP1, Cdc42, and the cadherin/catenin protein complex regulate Sertoli-germ cell adherens junction dynamics in the testis.
  • Using testis lysates for immunoprecipitation (IP), IQGAP1 was shown to associate with E-cadherin, N-cadherin, and beta-catenin (but not beta1-integrin and nectin-2), as well as with actin and vimentin (but not alpha-tubulin).

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  • [Copyright] 2005 Wiley-Liss, Inc.
  • (PMID = 15389538.001).
  • [ISSN] 0021-9541
  • [Journal-full-title] Journal of cellular physiology
  • [ISO-abbreviation] J. Cell. Physiol.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / U01 HD45908; United States / NICHD NIH HHS / HD / U54 HD29990
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cadherins; 0 / Ctnnb1 protein, rat; 0 / Cytoskeletal Proteins; 0 / IQ motif containing GTPase activating protein 1; 0 / Macromolecular Substances; 0 / Trans-Activators; 0 / beta Catenin; 0 / ras GTPase-Activating Proteins; EC 3.6.5.2 / cdc42 GTP-Binding Protein
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16. Lu X, Yu T, Ma M, Jin C, Liu Q, Wu S, Pan L: [Effect on the testis development and StAR, CYP19a1 and CYP11a1 expression of prepubertal male rats after sub-acute exposure to DEHP]. Wei Sheng Yan Jiu; 2010 May;39(3):263-7
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  • [Title] [Effect on the testis development and StAR, CYP19a1 and CYP11a1 expression of prepubertal male rats after sub-acute exposure to DEHP].
  • OBJECTIVE: To study the effect of DEHP on testis development and the related gene expression in prepubertal male rats after 28 days exposure in order to explore the mechanism of genital toxicity.
  • After decapitation 28 days later,the organ coefficient of testis was measured.
  • Meanwhile the morphological changes of testis and epididymis were observed by HE staining under optical microscopes.
  • The total RNA of testis was extracted and cDNA synthesis was followed as the manual instruction of RT-PCR kit.
  • Both the weight and the organ coefficient of testis were also degraded, and there were statistical significance between the 1000 mg/kg DEHP group and the control (F = 105.545, P < 0.05).
  • The serious morphological changes of testis and epididymis were shown in 100, 1000 mg/kg DEHP group.
  • [MeSH-major] Aromatase / metabolism. Cholesterol Side-Chain Cleavage Enzyme / metabolism. Diethylhexyl Phthalate / toxicity. Environmental Exposure / adverse effects. Phosphoproteins / metabolism. Testis / growth & development

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  • (PMID = 20568448.001).
  • [ISSN] 1000-8020
  • [Journal-full-title] Wei sheng yan jiu = Journal of hygiene research
  • [ISO-abbreviation] Wei Sheng Yan Jiu
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Endocrine Disruptors; 0 / Phosphoproteins; 0 / steroidogenic acute regulatory protein; C42K0PH13C / Diethylhexyl Phthalate; EC 1.14.14.1 / Aromatase; EC 1.14.15.6 / Cholesterol Side-Chain Cleavage Enzyme
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17. Lin Z, Lou Y, Squires EJ: Identification of a single nucleotide polymorphism in porcine testis cytochrome P450-c17 (CYP17) and its effect on steroidogenesis. Biochem Genet; 2005 Oct;43(9-10):531-42
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  • [Title] Identification of a single nucleotide polymorphism in porcine testis cytochrome P450-c17 (CYP17) and its effect on steroidogenesis.
  • This study suggests that the synthesis of androstenone in pig testis is not directly affected by any polymorphisms in the coding region of the porcine CYP17 gene.
  • [MeSH-major] Amino Acid Substitution / genetics. Androsterone / biosynthesis. Polymorphism, Single Nucleotide. Steroid 17-alpha-Hydroxylase / genetics. Testis / metabolism

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  • (PMID = 16341769.001).
  • [ISSN] 0006-2928
  • [Journal-full-title] Biochemical genetics
  • [ISO-abbreviation] Biochem. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] C24W7J5D5R / Androsterone; EC 1.14.99.9 / Steroid 17-alpha-Hydroxylase
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18. Kempkensteffen C, Hinz S, Krause H, Jager T, Köllermann J, Weikert S, Christoph F, Schostak M, Miller K, Schrader M: Expression of splicing variants of the inhibitor of apoptosis livin in testicular germ cell tumors. Tumour Biol; 2008;29(2):76-82
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  • [Title] Expression of splicing variants of the inhibitor of apoptosis livin in testicular germ cell tumors.
  • The inhibitor of apoptosis family member livin is expressed in several neoplasms but is absent in most benign tissues.
  • Livin has therefore been evaluated as a diagnostic and prognostic marker and recently gained much attention as a target for tumor therapy.
  • We evaluated the expression of livin splicing variants in 131 testicular germ cell tumors (TGCT) compared to 20 normal testicular tissue samples using dual-color real-time RT-PCR and Western blot analysis.
  • None of the splicing variants could be detected in normal testicular tissue.
  • Livin expression was strongly related to TGCT differentiation but not to clinical tumor stage and patient age.
  • Our findings suggest livin to be implicated in testicular tumorigenesis and to be related to the histological TGCT subtype.
  • Considering that livin expression is restricted to malignant testicular tissue, it appears reasonable to conduct further investigations regarding its targeted inhibition in TGCT.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / genetics. Apoptosis / physiology. Gene Expression Regulation, Neoplastic / physiology. Inhibitor of Apoptosis Proteins / genetics. Neoplasm Proteins / genetics. Neoplasms, Germ Cell and Embryonal / genetics. Protein Splicing / genetics. Testicular Neoplasms / genetics
  • [MeSH-minor] Carcinoma, Embryonal / genetics. Carcinoma, Embryonal / metabolism. Carcinoma, Embryonal / pathology. Humans. Male. Protein Isoforms / genetics. Protein Isoforms / metabolism. Seminoma / genetics. Seminoma / metabolism. Seminoma / pathology. Testis / cytology. Testis / metabolism

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  • [Copyright] (c) 2008 S. Karger AG, Basel
  • (PMID = 18515985.001).
  • [ISSN] 1423-0380
  • [Journal-full-title] Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • [ISO-abbreviation] Tumour Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / BIRC7 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Neoplasm Proteins; 0 / Protein Isoforms
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19. Hiebert SM, Green SA, Yellon SM: Daily timed melatonin feedings mimic effects of short days on testis regression and cortisol in circulation in Siberian hamsters. Gen Comp Endocrinol; 2006 May 1;146(3):211-6
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  • [Title] Daily timed melatonin feedings mimic effects of short days on testis regression and cortisol in circulation in Siberian hamsters.
  • Melatonin treatment induced testicular regression and elevated serum cortisol, effects comparable to those in hamsters exposed to short days.
  • [MeSH-major] Diet. Hydrocortisone / blood. Melatonin / administration & dosage. Photoperiod. Testis / physiology

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  • (PMID = 16386252.001).
  • [ISSN] 0016-6480
  • [Journal-full-title] General and comparative endocrinology
  • [ISO-abbreviation] Gen. Comp. Endocrinol.
  • [Language] eng
  • [Grant] United States / PHS HHS / / 40254
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] JL5DK93RCL / Melatonin; WI4X0X7BPJ / Hydrocortisone
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20. de Souza Predes F, Diamante MA, Dolder H: Testis response to low doses of cadmium in Wistar rats. Int J Exp Pathol; 2010 Apr;91(2):125-31
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  • [Title] Testis response to low doses of cadmium in Wistar rats.
  • Quantification of these alterations, especially in the testis, was measured using morphometry.
  • The higher dose caused significant reduction in testis and epididymis weight, gonadossomatic index and length of seminiferous tubule (ST) after 7 and 56 days.
  • Scanning electron microscopy examination of the testis showed that, in the group cadmium treated (1.2 mg/kg) and killed after 56 days, the interstitial tissue presents a compact and fibrous appearance with absence of fenestrae.
  • The results show that a very small difference of Cd dose causes a sudden increase in testicular damage, apparently overpowering this tissue's natural defences.
  • [MeSH-major] Cadmium / toxicity. Testis / drug effects

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  • (PMID = 20015210.001).
  • [ISSN] 1365-2613
  • [Journal-full-title] International journal of experimental pathology
  • [ISO-abbreviation] Int J Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 00BH33GNGH / Cadmium
  • [Other-IDs] NLM/ PMC2965898
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21. Mehra BR, Thawait AP, Narang RR, Gangane NM, Vyas VJ: Adenocarcinoma of the rete testis with uncommon presentation as haematocele. Singapore Med J; 2007 Dec;48(12):e311-3
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  • [Title] Adenocarcinoma of the rete testis with uncommon presentation as haematocele.
  • Adenocarcinoma of the rete testis was encountered in a 62-year-old man.
  • The tumour was localised in the region of the testicular hilum as a greyish-white nodule that showed no involvement of the adjacent testicular parenchyma or the epididymis.
  • On microscopical examination, there was a well-differentiated adenocarcinoma separated by fibrovascular stroma, entirely confined to the testicular hilum.
  • This primary carcinoma of the rete testis presented as a haematocele.
  • [MeSH-major] Adenocarcinoma / pathology. Hematocele / pathology. Rete Testis / pathology. Testicular Neoplasms / pathology

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  • (PMID = 18043825.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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22. Hemmati S, Zarnani AH, Mahmoudi AR, Sadeghi MR, Soltanghoraee H, Akhondi MM, Tarahomi M, Jeddi-Tehrani M, Rabbani H: Ectopic Expression of Sortilin 1 (NTR-3) in Patients with Ovarian Carcinoma. Avicenna J Med Biotechnol; 2009 Jul;1(2):125-31
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  • Sortilin 1 (NTR-3) is a 95-100 kDa protein normally expressed in heart, brain, placenta, skeletal muscle, spinal cord, thyroid, and testis.
  • This finding may introduce sortilin 1 as a novel tumor marker for diagnosis of ovarian carcinoma and may signify its therapeutic value in targeted therapy.

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  • (PMID = 23407681.001).
  • [ISSN] 2008-2835
  • [Journal-full-title] Avicenna journal of medical biotechnology
  • [ISO-abbreviation] Avicenna J Med Biotechnol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC3558127
  • [Keywords] NOTNLM ; Ectopic / Expression / NTR / Ovarian carcinoma / Sortilin
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23. de Wind A, Meert V, Chahidi N, Theunis A, Somerhausen Nde S: [Retiform haemangioendothelioma: a case report]. Ann Pathol; 2009 Dec;29(6):491-4
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  • Histologically, it is characterized by distinctive arborizing blood vessels resembling "rete testis" and lined by endothelial cells with characteristic hobnail morphology.
  • Spindle cell hemangio(endothelio)ma is currently regarded as a benign reactive lesion.
  • The vascular lesions fulfilling the strict definition of hemangioendothelioma include retiform hemangioendothelioma, papillary intralymphatic angioendothelioma "Dabska's tumor", composite hemangioendothelioma and perhaps the controversial polymorphic hemangioendothelioma.
  • [MeSH-minor] Antigens, CD / analysis. Antigens, CD31 / analysis. Antigens, CD34 / analysis. Endothelium, Vascular / pathology. Humans. Male. Middle Aged. Neoplasm Metastasis. Tibia / pathology. Vascular Neoplasms / pathology

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  • (PMID = 20005438.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD31; 0 / Antigens, CD34
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24. Liu L, Ding H, Liu D, Lu Q, Rousseaux S, Wu F: [Design of oligonucleotide probes for cancer-testis genes for cancer diagnosis microarray]. Sichuan Da Xue Xue Bao Yi Xue Ban; 2009 Mar;40(2):330-3, 336
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  • [Title] [Design of oligonucleotide probes for cancer-testis genes for cancer diagnosis microarray].
  • OBJECTIVE: To design oligonucleotide probes for Cancer-testis (CT) genes for a microarray, which will be dedicated to a transcriptomic analysis of testis-specific genes in tumors and elucidation of the role of CT genes in the process of tumorigenesis.
  • CONCLUSION: The combinative use of the two probe designing tools, IDT and MEDIANTE, can successfully design oligonucleotide probes for cancer-testis genes.
  • [MeSH-major] Genes, Neoplasm. Oligonucleotide Array Sequence Analysis. Oligonucleotide Probes. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Antigens, Neoplasm / genetics. Antigens, Neoplasm / metabolism. Gene Expression Regulation, Neoplastic. Humans. Male

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  • (PMID = 19462920.001).
  • [ISSN] 1672-173X
  • [Journal-full-title] Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
  • [ISO-abbreviation] Sichuan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Oligonucleotide Probes
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25. Paronetto MP, Messina V, Bianchi E, Barchi M, Vogel G, Moretti C, Palombi F, Stefanini M, Geremia R, Richard S, Sette C: Sam68 regulates translation of target mRNAs in male germ cells, necessary for mouse spermatogenesis. J Cell Biol; 2009 Apr 20;185(2):235-49
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  • Expression of a subset of messenger mRNAs (mRNAs) is affected in the testis of knockout mice.
  • [MeSH-minor] Animals. Cell Cycle Proteins / genetics. Cell Cycle Proteins / metabolism. Female. Fertility / physiology. Gene Expression Regulation. Genes, Reporter. Male. Meiosis / physiology. Mice. Mice, Knockout. Microtubule-Associated Proteins / genetics. Microtubule-Associated Proteins / metabolism. Pregnancy. Spermatozoa / cytology. Spermatozoa / physiology. Testis / cytology. Testis / physiology

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  • (PMID = 19380878.001).
  • [ISSN] 1540-8140
  • [Journal-full-title] The Journal of cell biology
  • [ISO-abbreviation] J. Cell Biol.
  • [Language] eng
  • [Grant] Italy / Telethon / / GGP04118
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Microtubule-Associated Proteins; 0 / PF20 protein, mouse; 0 / RNA, Messenger; 0 / Spy1 protein, mouse; 155982-08-4 / Nedd1 protein, mouse
  • [Other-IDs] NLM/ PMC2700383
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26. Friborg JT, Melbye M: Cancer patterns in Inuit populations. Lancet Oncol; 2008 Sep;9(9):892-900
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  • Although malignant diseases were believed to be almost non-existent in Inuit populations during the beginning of the 20th century, the increasing life expectancy within these populations showed a distinct pattern, characterised by a high risk of Epstein-Barr virus-associated carcinomas of the nasopharynx and salivary glands, and a low risk of tumours common in white populations, including cancer of the prostate, testis, and haemopoietic system.

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  • [CommentIn] Lancet Oncol. 2008 Dec;9(12):1124 [19038761.001]
  • (PMID = 18760245.001).
  • [ISSN] 1474-5488
  • [Journal-full-title] The Lancet. Oncology
  • [ISO-abbreviation] Lancet Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 72
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27. Takahashi K, Naito M, Terayama H, Qu N, Cheng L, Tainosho S, Itoh M: Immunomorphological aspects of the tubuli recti and the surrounding interstitium in normal mice. Int J Androl; 2007 Feb;30(1):21-7
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  • The tubuli recti (TR) are immunologically special, because the lymphocytes preferably accumulate around them during the course of T-cell dependent testicular autoimmunity in mice.
  • This finding implies that the testicular interstitium around the TR is where autoreactive lymphocytes can gain access to autoimmunogenic germ cell antigens.
  • Three-dimensional analysis showed that 14-16 TR appeared to be connected to the rete testis (RT).
  • [MeSH-major] Leydig Cells / immunology. Leydig Cells / ultrastructure. Lymphocytes / immunology. Rete Testis / immunology. Rete Testis / ultrastructure

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  • (PMID = 17328721.001).
  • [ISSN] 0105-6263
  • [Journal-full-title] International journal of andrology
  • [ISO-abbreviation] Int. J. Androl.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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28. Wakle M, Khole V: A sperm cytoskeletal protein TSA70 is a novel phosphorylated member of cenexin/odf2 family. Biochem Biophys Res Commun; 2007 Mar 9;354(2):528-34
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  • Using post-vasectomy monoclonal antibody we recently identified a testis specific sperm auto-antigen called TSA70 which is post-meiotically expressed and plays a role in sperm motility and capacitation-acrosome reaction.

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  • (PMID = 17240355.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Autoantigens; 0 / Cytoskeletal Proteins; 0 / Heat-Shock Proteins; 0 / Odf2 protein, rat; 0 / testis-specific antigen 70, rat
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29. Cederroth CR, Pitetti JL, Papaioannou MD, Nef S: Genetic programs that regulate testicular and ovarian development. Mol Cell Endocrinol; 2007 Feb;265-266:3-9
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  • [Title] Genetic programs that regulate testicular and ovarian development.
  • The gonadal primordium is the only tissue in mammals that has two divergent developmental fates leading ultimately to the formation of either a testis or an ovary.
  • [MeSH-major] Gene Expression Regulation, Developmental. Ovary / embryology. Sex Determination Processes. Testis / embryology

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  • (PMID = 17208359.001).
  • [ISSN] 0303-7207
  • [Journal-full-title] Molecular and cellular endocrinology
  • [ISO-abbreviation] Mol. Cell. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Ireland
  • [Number-of-references] 28
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30. Saha S, Ramanathan A, Rangarajan PN: Regulation of Ca2+/calmodulin kinase II inhibitor alpha (CaMKIINalpha) in virus-infected mouse brain. Biochem Biophys Res Commun; 2006 Nov 17;350(2):444-9
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  • The alpha and beta isoforms of rat Ca(2+)/calmodulin kinase II inhibitor (CaMKIINalpha/beta) expressed in brain or brain and testis, respectively, are potent inhibitors of Ca(2+)/calmodulin kinase II (CaMKII) in vitro.

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  • (PMID = 17010311.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Camk2n2 protein, mouse; 0 / Carrier Proteins; 0 / RNA, Messenger; EC 2.7.11.17 / Calcium-Calmodulin-Dependent Protein Kinase Type 2; EC 2.7.11.17 / Calcium-Calmodulin-Dependent Protein Kinases
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31. Corradi HR, Schwager SL, Nchinda AT, Sturrock ED, Acharya KR: Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design. J Mol Biol; 2006 Mar 31;357(3):964-74
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  • Previously we determined the structure of testis ACE (C domain); here we present the crystal structure of the N domain of sACE (both in the presence and absence of the antihypertensive drug lisinopril) in order to aid the understanding of how these two domains differ in specificity and function.

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  • (PMID = 16476442.001).
  • [ISSN] 0022-2836
  • [Journal-full-title] Journal of molecular biology
  • [ISO-abbreviation] J. Mol. Biol.
  • [Language] eng
  • [Databank-accession-numbers] PDB/ 2C6F/ 2C6N
  • [Grant] United Kingdom / Wellcome Trust / / 070060; United Kingdom / Wellcome Trust / / 071047
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Angiotensin-Converting Enzyme Inhibitors; EC 3.4.15.1 / Peptidyl-Dipeptidase A
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32. Dobrzyńska MM, Czajka U, Słowikowska MG: Reproductive effects after exposure of male mice to vincristine and to a combination of X-rays and vincristine. Reprod Fertil Dev; 2005;17(8):759-67
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  • Both VCR and X-rays plus VCR reduced testis weight and sperm count, caused deterioration with respect to sperm morphology, and caused a slight increase in DNA damage.
  • [MeSH-minor] Animals. Comet Assay. DNA Damage. Dose-Response Relationship, Drug. Dose-Response Relationship, Radiation. Male. Mice. Organ Size. Testis / drug effects. Testis / radiation effects

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  • (PMID = 16476202.001).
  • [ISSN] 1031-3613
  • [Journal-full-title] Reproduction, fertility, and development
  • [ISO-abbreviation] Reprod. Fertil. Dev.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine
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33. Kiss A, Mikkelsen JD: Oxytocin--anatomy and functional assignments: a minireview. Endocr Regul; 2005 Sep;39(3):97-105
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  • OXY is also produced in peripheral tissues, e.g., uterus, placenta, amnion, corpus luteum, testis, and heart.

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  • (PMID = 16468232.001).
  • [ISSN] 1210-0668
  • [Journal-full-title] Endocrine regulations
  • [ISO-abbreviation] Endocr Regul
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Slovakia
  • [Chemical-registry-number] 50-56-6 / Oxytocin
  • [Number-of-references] 77
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34. Ueno M, Itoh M, Kong L, Sugihara K, Asano M, Takakura N: PSF1 is essential for early embryogenesis in mice. Mol Cell Biol; 2005 Dec;25(23):10528-32
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  • We originally cloned the mouse ortholog of PSF1 from a hematopoietic stem cell cDNA library and found that PSF1 is expressed in blastocysts, adult bone marrow, and testis, in which the stem cell system is active.


35. Amann RP: Evaluating testis function non-invasively: how epidemiologist-andrologist teams might better approach this task. Hum Reprod; 2010 Jan;25(1):22-8
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  • [Title] Evaluating testis function non-invasively: how epidemiologist-andrologist teams might better approach this task.
  • Opinions herein focus on epidemiology-based publications using semen to study testis function, but several have broader applicability.
  • [MeSH-major] Spermatogenesis. Testicular Diseases / diagnosis. Testis / physiopathology

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  • (PMID = 19887497.001).
  • [ISSN] 1460-2350
  • [Journal-full-title] Human reproduction (Oxford, England)
  • [ISO-abbreviation] Hum. Reprod.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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36. Antonangeli F, Petrungaro S, Coluccia P, Filippini A, Ziparo E, Giampietri C: Testis atrophy and reduced sperm motility in transgenic mice overexpressing c-FLIP(L). Fertil Steril; 2010 Mar 15;93(5):1407-14
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  • [Title] Testis atrophy and reduced sperm motility in transgenic mice overexpressing c-FLIP(L).
  • OBJECTIVE: To study the effect of c-FLIP overexpression in testicular germ cells.
  • DESIGN: A novel transgenic mouse model overexpressing the apoptotic modulator c-FLIP in the testis was generated.
  • INTERVENTION(S): Spermatozoa motility and testis histological, immunohistochemical, and Western blot analyses were carried out in transgenic and control derived specimens.
  • MAIN OUTCOME MEASURE(S): Testis morphology, sperm motility, and germ cell apoptosis were assayed.
  • As a consequence of such overexpression, a dramatic loss of germ cells was observed, resulting in testicular atrophy associated with reduced sperm motility.
  • CONCLUSION(S): The data show that c-FLIP(L) forced expression in haploid male germ cells has detrimental effects on spermatogenesis and sperm quality and reveal a possible mechanism underlying the onset of testicular atrophy.
  • [MeSH-major] CASP8 and FADD-Like Apoptosis Regulating Protein / metabolism. Sperm Motility. Spermatozoa / metabolism. Testis / metabolism

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  • [Copyright] Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
  • (PMID = 19285665.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / CASP8 and FADD-Like Apoptosis Regulating Protein; 0 / Cflar protein, mouse; 0 / Proteins; 0 / Stra8 protein, mouse; EC 3.4.22.- / Casp8 protein, mouse; EC 3.4.22.- / Caspase 8
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37. Celik-Ozenci C, Sahin Z, Ustunel I, Akkoyunlu G, Erdogru T, Korgun ET, Baykara M, Demir R: The Fas system may have a role in male reproduction. Fertil Steril; 2006 Apr;85 Suppl 1:1168-78
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  • OBJECTIVE: To assess what the distributions of Fas system proteins are in normal rat testicular tissue; to assess whether there is a change in these distributions and in expression levels with experimentally-induced varicocele of 9, 11, and 13 weeks; and to assess whether there is a relationship between apoptosis and the Fas system in varicocele-induced rat testis.
  • RESULT(S): In control testis, we detected the expression of FasL in spermatids, interestingly at the progressing stages of acrosome formation and in the heads of the spermatozoa being released to lumen.
  • [MeSH-major] Fertility. Membrane Glycoproteins / metabolism. Receptors, Tumor Necrosis Factor / metabolism. Testis / metabolism. Tumor Necrosis Factors / metabolism. Varicocele / metabolism

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  • (PMID = 16616089.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD95; 0 / FASLG protein, human; 0 / Fas Ligand Protein; 0 / Membrane Glycoproteins; 0 / Receptors, Tumor Necrosis Factor; 0 / Tnfrsf6 protein, rat; 0 / Tnfsf6 protein, rat; 0 / Tumor Necrosis Factors
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38. Handa R, Kale R, Harjai M, Minocha A: Single scrotal incision orchiopexy for palpable undescended testis. Asian J Surg; 2006 Jan;29(1):25-7
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  • [Title] Single scrotal incision orchiopexy for palpable undescended testis.
  • OBJECTIVE: To prospectively evaluate the Bianchi single scrotal incision technique for orchiopexy in boys with palpable undescended testis.
  • Testicular size and position were assessed at 2 and 6 weeks and 6 months.
  • CONCLUSION: Single scrotal incision orchiopexy without ligation of the patent processus vaginalis has proved to be simple, safe and effective in selected cases compared with the standard two-incision approach in the treatment of palpable undescended testis.

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  • (PMID = 16428094.001).
  • [ISSN] 1015-9584
  • [Journal-full-title] Asian journal of surgery
  • [ISO-abbreviation] Asian J Surg
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] China
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39. Brailoiu GC, Dun SL, Yin D, Yang J, Chang JK, Dun NJ: Insulin-like 6 immunoreactivity in the mouse brain and testis. Brain Res; 2005 Apr 8;1040(1-2):187-90
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  • [Title] Insulin-like 6 immunoreactivity in the mouse brain and testis.
  • Insulin-like 6 immunoreactivity (irINSL6) was detected in Leydig cells of the mouse testis.
  • The presence of irINSL6 in discrete populations of hypothalamic and brainstem neurons and in Leydig cells of the testis suggests a diverse biological function of this novel peptide.
  • [MeSH-major] Brain Chemistry / physiology. Insulin / analogs & derivatives. Insulin / analysis. Testis / chemistry

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  • (PMID = 15804440.001).
  • [ISSN] 0006-8993
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL58654; United States / NINDS NIH HHS / NS / NS18710
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Insl6 protein, mouse; 0 / Insulin; 0 / Intracellular Signaling Peptides and Proteins
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40. Li N, Sun H, Wu Q, Tao D, Zhang S, Ma Y: Cloning and expression analysis of a novel mouse zinc finger protein gene Znf313 abundantly expressed in testis. J Biochem Mol Biol; 2007 Mar 31;40(2):270-6
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  • [Title] Cloning and expression analysis of a novel mouse zinc finger protein gene Znf313 abundantly expressed in testis.
  • Revealed by Northern blot and RT-PCR, full mRNA consists of 2.16 kb and widely expresses in tissues as a single transcript, most abundantly in heart, liver, kidney and testis.
  • The expression of Znf313 in testis is detected in all development stages.
  • [MeSH-major] Gene Expression Profiling. Testis / metabolism. Transcription Factors / genetics. Transcription Factors / metabolism. Zinc Fingers

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  • (PMID = 17394778.001).
  • [ISSN] 1225-8687
  • [Journal-full-title] Journal of biochemistry and molecular biology
  • [ISO-abbreviation] J. Biochem. Mol. Biol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AL589870
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / RNA, Messenger; 0 / Transcription Factors; 0 / Znf313 protein, mouse
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41. Stukenborg JB, Colón E, Söder O: Ontogenesis of testis development and function in humans. Sex Dev; 2010 Sep;4(4-5):199-212
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  • [Title] Ontogenesis of testis development and function in humans.
  • [MeSH-major] Organogenesis. Testis / embryology

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  • (PMID = 20664245.001).
  • [ISSN] 1661-5433
  • [Journal-full-title] Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation
  • [ISO-abbreviation] Sex Dev
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Switzerland
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42. Ehrmann I, Elliott DJ: Expression and functions of the star proteins Sam68 and T-STAR in mammalian spermatogenesis. Adv Exp Med Biol; 2010;693:67-81
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  • The homologous T-STAR protein has a much more restricted anatomic expression pattern than Sam68, with highest levels seen in the testis and the developing brain.

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  • (PMID = 21189686.001).
  • [ISSN] 0065-2598
  • [Journal-full-title] Advances in experimental medicine and biology
  • [ISO-abbreviation] Adv. Exp. Med. Biol.
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / / BB/D013917/1; United Kingdom / Biotechnology and Biological Sciences Research Council / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / DNA-Binding Proteins; 0 / KHDRBS1 protein, human; 0 / KHDRBS3 protein, human; 0 / Khdrbs1 protein, mouse; 0 / Khdrbs3 protein, mouse; 0 / RNA-Binding Proteins
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43. Kamminga LM, Luteijn MJ, den Broeder MJ, Redl S, Kaaij LJ, Roovers EF, Ladurner P, Berezikov E, Ketting RF: Hen1 is required for oocyte development and piRNA stability in zebrafish. EMBO J; 2010 Nov 03;29(21):3688-700
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  • We show that zebrafish hen1 is specifically expressed in germ cells and is essential for maintaining a female germ line, whereas it is dispensable in the testis.
  • [MeSH-minor] Amino Acid Sequence. Animals. Blotting, Northern. Embryo, Nonmammalian / cytology. Embryo, Nonmammalian / metabolism. Female. Immunoprecipitation. In Situ Hybridization. Male. Molecular Sequence Data. Mutation / genetics. RNA 3' End Processing / physiology. RNA, Messenger / genetics. Retroelements. Reverse Transcriptase Polymerase Chain Reaction. Sequence Homology, Amino Acid. Subcellular Fractions. Testis / cytology. Testis / metabolism

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  • (PMID = 20859253.001).
  • [ISSN] 1460-2075
  • [Journal-full-title] The EMBO journal
  • [ISO-abbreviation] EMBO J.
  • [Language] eng
  • [Databank-accession-numbers] GEO/ GSE33582
  • [Grant] International / European Research Council / / 202819
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / RNA, Small Interfering; 0 / Retroelements; 0 / Zebrafish Proteins; 0 / Ziwi protein, zebrafish; EC 2.1.1.- / Hen1 protein, zebrafish; EC 2.1.1.- / Methyltransferases; WHI7HQ7H85 / Uridine
  • [Other-IDs] NLM/ PMC2982757
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44. Stewart MJ, Stewart P, Soonklang N, Linthong V, Hanna PJ, Duan W, Sobhon P: Spermatogenesis in the blue swimming crab, Portunus pelagicus, and evidence for histones in mature sperm nuclei. Tissue Cell; 2010 Jun;42(3):137-50
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  • The testis is composed of anterior (AT) and posterior (PT) lobes, that are partitioned into lobules by connective tissue trabecula, and further divided into zones (germinal, transformation and evacuation), each with various stages of cellular differentiation.

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20413138.001).
  • [ISSN] 1532-3072
  • [Journal-full-title] Tissue & cell
  • [ISO-abbreviation] Tissue Cell
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Histones
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45. Wajner SM, Wagner MS, Maia AL: Clinical implications of altered thyroid status in male testicular function. Arq Bras Endocrinol Metabol; 2009 Nov;53(8):976-82
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  • [Title] Clinical implications of altered thyroid status in male testicular function.
  • Although for many years the testis was thought to be a thyroid-hormone unresponsive organ, studies of the last decades have demonstrated that thyroid dysfunction is associated not only with abnormalities in morphology and function of testes, but also with decreased fertility and alterations of sexual activity in men.
  • Nowadays, the participation of triiodothyronine (T3) in the control of Sertoli and Leydig cell proliferation, testicular maturation, and steroidogenesis is widely accepted, as well as the presence of thyroid hormone transporters and receptors in testicular cells throughout the development process and in adulthood.
  • [MeSH-major] Testis / physiology. Thyroid Hormones / physiology

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  • (PMID = 20126850.001).
  • [ISSN] 1677-9487
  • [Journal-full-title] Arquivos brasileiros de endocrinologia e metabologia
  • [ISO-abbreviation] Arq Bras Endocrinol Metabol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Thyroid Hormones
  • [Number-of-references] 67
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46. Hahn Y: Molecular evolution of TEPP protein genes in metazoans. Biochem Genet; 2009 Oct;47(9-10):651-64
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  • TEPP is a gene expressed in human reproductive organs such as testis, prostate, and placenta.

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  • (PMID = 19548082.001).
  • [ISSN] 1573-4927
  • [Journal-full-title] Biochemical genetics
  • [ISO-abbreviation] Biochem. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proteins; 0 / RNA Splice Sites; 0 / TEPP protein, human
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47. Maloveryan A, Finta C, Osterlund T, Kogerman P: A possible role of mouse Fused (STK36) in Hedgehog signaling and Gli transcription factor regulation. J Cell Commun Signal; 2007 Dec;1(3-4):165-73
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  • Of the tested tissues only brain and testis showed significant expression.
  • Thus, we turned to RNAi in order to test if mFu would be important for Hedgehog signaling after all.


48. Sakudo A, Yoshimura E, Tsenkova R, Ikuta K, Onodera T: Native state of metals in non-digested tissues by partial least squares regression analysis of visible and near-infrared spectra. J Toxicol Sci; 2007 May;32(2):135-41
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  • A procedure has been used for the classification and quantification of metals on the basis of a chemometric analysis of visible and near-infrared (Vis-NIR) spectra of metals such as Cu, Mn and Fe in the brain, liver, kidney and testis of mice without digestion.
  • [MeSH-minor] Animals. Brain Chemistry. Kidney / chemistry. Least-Squares Analysis. Liver / chemistry. Male. Mice. Mice, Inbred C57BL. Testis / chemistry

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  • (PMID = 17538238.001).
  • [ISSN] 0388-1350
  • [Journal-full-title] The Journal of toxicological sciences
  • [ISO-abbreviation] J Toxicol Sci
  • [Language] eng
  • [Publication-type] Journal Article; Validation Studies
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Metals, Heavy
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49. Conrad M, Moreno SG, Sinowatz F, Ursini F, Kölle S, Roveri A, Brielmeier M, Wurst W, Maiorino M, Bornkamm GW: The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability. Mol Cell Biol; 2005 Sep;25(17):7637-44
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  • The selenoenzyme phospholipid hydroperoxide glutathione peroxidase (PHGPx) is regarded as the major molecular target of selenodeficiency in rodents, accounting for most of the histopathological and structural abnormalities of testicular tissue and male germ cells.
  • While both morphological analysis of testis and epididymis and sperm parameter measurements did not show any apparent abnormality, toluidine blue and acridine orange stainings of spermatozoa indicated defective chromatin condensation in the KO sperm isolated from the caput epididymis.

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  • (PMID = 16107710.001).
  • [ISSN] 0270-7306
  • [Journal-full-title] Molecular and cellular biology
  • [ISO-abbreviation] Mol. Cell. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromatin; 0 / Sulfhydryl Compounds; EC 1.11.1.12 / phospholipid-hydroperoxide glutathione peroxidase; EC 1.11.1.9 / Glutathione Peroxidase
  • [Other-IDs] NLM/ PMC1190272
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50. Dobrinski I: Advances and applications of germ cell transplantation. Hum Fertil (Camb); 2006 Mar;9(1):9-14
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  • When male germ line stem cells are transplanted from the testis of a fertile donor animal to the testis of an infertile recipient they can establish donor-derived spermatogenesis in the recipient testis, and the resulting sperm can transmit the genotype of the donor to the offspring of the recipient.
  • As an alternative to transplantation of isolated germ cells to a recipient testis, ectopic grafting of testis tissue from diverse mammalian donor species, including primates, into a mouse host represents a novel possibility to study spermatogenesis, to investigate the effects of toxins or drugs with the potential to enhance or suppress male fertility, and to produce fertile sperm from immature donors.
  • Therefore, transplantation of germ cells or xenografting of testis tissue are uniquely valuable approaches for the study, preservation and manipulation of male fertility in mammalian species.
  • [MeSH-minor] Animals. Humans. Infertility / surgery. Male. Testis / transplantation. Transplantation, Heterologous

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  • (PMID = 16581717.001).
  • [ISSN] 1464-7273
  • [Journal-full-title] Human fertility (Cambridge, England)
  • [ISO-abbreviation] Hum Fertil (Camb)
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / 1 R21 RR017419-01; United States / NICHD NIH HHS / HD / 1R41 HD044780-01; United States / NCRR NIH HHS / RR / 5R01RR017359-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
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51. Martins RS, Deloffre LA, Mylonas CC, Power DM, Canário AV: Developmental expression of DAX1 in the European sea bass, Dicentrarchus labrax: lack of evidence for sexual dimorphism during sex differentiation. Reprod Biol Endocrinol; 2007;5:19
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  • METHODS: A full length European sea bass DAX1 cDNA (sbDAX1) was isolated by screening a testis cDNA library.
  • RESULTS: The sbDAX1 is expressed as a single transcript in testis and ovary encoding a predicted protein of 301 amino acids.

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  • (PMID = 17537257.001).
  • [ISSN] 1477-7827
  • [Journal-full-title] Reproductive biology and endocrinology : RB&E
  • [ISO-abbreviation] Reprod. Biol. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Gonadal Steroid Hormones; 0 / RNA, Messenger; 0 / Receptors, Cytoplasmic and Nuclear
  • [Other-IDs] NLM/ PMC1891300
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52. Kim JW, Lee SH, Park YS, Jeong SH, Kim N, Lee DH, Lee HS: Transcriptome analysis of hepatitis B virus-associated small hepatocellular carcinoma by serial analysis of gene expression. Int J Oncol; 2009 Jul;35(1):129-37
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  • Seventeen genes were unequivocally matched to SAGE tags which were up-regulated 15-fold or higher in HCC compared to normal liver: four genes (fatty acid desaturase 2, alpha-L-2-fucosidase, testis-specific protein Y-encoded-like 2 and Gon-4-like) were significantly overexpressed in the HCC SAGE library compared to any other SAGE libraries of human normal tissues.
  • The significance of these genes with respect to carcinogenesis and early diagnosis of HCC needs to be elucidated in further studies.
  • [MeSH-major] Biomarkers, Tumor / genetics. Carcinoma, Hepatocellular / genetics. Gene Expression Profiling / methods. Gene Expression Regulation, Neoplastic. Hepatitis B / complications. Liver Neoplasms / genetics

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  • (PMID = 19513560.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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53. Tajchner L, Larkin JO, Bourke MG, Waldron R, Barry K, Eustace PW: Management of the acute scrotum in a district general hospital: 10-year experience. ScientificWorldJournal; 2009;9:281-6
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  • The primary objective of management is to avoid testicular loss.
  • The most common finding was torted cyst of Morgagni (63/119, 52.9%), followed by testicular torsion (41/119, 34.4%).
  • The majority of testicular torsions occurred in the pubertal group (22/41, 53.6%).
  • Only one patient in this group had an unsalvageable testis necessitating orchidectomy, a testicular loss rate in torsion of 2.4%.
  • Testicular salvage depends critically on early surgical intervention, so the delay incurred in diagnostic imaging may extend the period of ischaemia.
  • We report a low orchidectomy rate (2.4%) in testicular torsion.
  • [MeSH-major] Pain. Scrotum. Spermatic Cord Torsion / diagnosis. Testis / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Cysts / surgery. False Negative Reactions. Genital Diseases, Male / diagnosis. Genital Diseases, Male / surgery. Humans. Male. Middle Aged. Retrospective Studies. Time Factors

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  • (PMID = 19412556.001).
  • [ISSN] 1537-744X
  • [Journal-full-title] TheScientificWorldJournal
  • [ISO-abbreviation] ScientificWorldJournal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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54. Kalia S, Bansal MP: Diethyl maleate-induced oxidative stress leads to testicular germ cell apoptosis involving Bax and Bcl-2. J Biochem Mol Toxicol; 2008 Nov-Dec;22(6):371-81
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  • [Title] Diethyl maleate-induced oxidative stress leads to testicular germ cell apoptosis involving Bax and Bcl-2.
  • Testicular germ cell apoptosis is normally a continuous process throughout life.
  • However, massive testicular germ cell loss is known to result from a wide variety of cellular stresses including toxicant exposure.
  • The germ cell apoptosis was found to be increased as assessed by terminal deoxynucleotidyl transferase (TdT)-mediated deoxy-UTP biotin nick end labeling (TUNEL) staining, evaluation of histoarchitechture of testis, and germ cell numbers.
  • The prevalence and cellular localization of the above markers in testicular tissues of DEM-treated animals suggest the possible involvement of Bax/Bcl-2 in the male germ cell apoptosis.
  • [MeSH-major] Apoptosis / drug effects. Maleates / toxicity. Oxidative Stress / drug effects. Spermatozoa / cytology. Spermatozoa / drug effects. Testis / cytology. bcl-2-Associated X Protein / metabolism

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  • [Copyright] (c) 2008 Wiley Periodicals, Inc.
  • (PMID = 19110998.001).
  • [ISSN] 1099-0461
  • [Journal-full-title] Journal of biochemical and molecular toxicology
  • [ISO-abbreviation] J. Biochem. Mol. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Maleates; 0 / RNA, Messenger; 0 / bcl-2-Associated X Protein; G81WQB56OL / diethyl maleate
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55. Bastide C, Paparel P, Guillonneau B: Minimally invasive surgery in oncologic urology: a recent review. Curr Opin Urol; 2008 Mar;18(2):190-7
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  • Regarding bladder cancer, testis cancer and upper urinary tract transitional cell carcinoma, no recently published study has modified the current knowledge.

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  • (PMID = 18303542.001).
  • [ISSN] 0963-0643
  • [Journal-full-title] Current opinion in urology
  • [ISO-abbreviation] Curr Opin Urol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 56
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56. Zhang S, Huang N, Zhao XY, Wang QS, Yang Y, Cheng Y, Ju HM, Xiong WB, Ou ZR, Wu Q, Wang BY: [Effect of human beta defensin 2 on Staphylococcus aureus infection: in vivo study with transgenic mice]. Zhonghua Yi Xue Za Zhi; 2006 Jul 11;86(26):1834-6
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  • A widespread expression of HBD-2 gene was found in many tissues of the transgenic mice: trachea, lung, intestine, esophagus, testis, spleen, skin, endothelium, brain, etc.

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  • (PMID = 17054860.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / beta-Defensins
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57. Taketo T, Lee CH, Zhang J, Li Y, Lee CY, Lau YF: Expression of SRY proteins in both normal and sex-reversed XY fetal mouse gonads. Dev Dyn; 2005 Jun;233(2):612-22
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  • Sry, a single-copy gene on the Y-chromosome, acts dominantly to trigger differentiation of a testis from a gonadal primordium that otherwise develops into an ovary in mammals.
  • However, the mode of SRY action in testis determination remains largely unknown.
  • Immunofluorescent double labeling revealed that the SRY protein was detected in the Sertoli cell lineage and was swiftly down-regulated concurrently with testis cord organization.
  • Surprisingly, however, the SRY protein was detected in the entire gonad from the onset of its expression, not in parallel to the spatiotemporal pattern of testis cord organization.
  • SRY down-regulation was considerably delayed, compared with control B6.XY gonads and was not associated with testis cord organization in B6.Y(TIR) gonads.
  • We conclude that the testis-determining pathway is impaired at the site of SRY action in the B6.Y(TIR) gonad.

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc
  • (PMID = 15789443.001).
  • [ISSN] 1058-8388
  • [Journal-full-title] Developmental dynamics : an official publication of the American Association of Anatomists
  • [ISO-abbreviation] Dev. Dyn.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / 1 R01 HD38117
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / Sex-Determining Region Y Protein; 0 / Sry protein, mouse; 0 / Transcription Factors
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58. Saradha B, Mathur PP: Effect of environmental contaminants on male reproduction. Environ Toxicol Pharmacol; 2006 Jan;21(1):34-41
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  • Decreasing trend of male fertility in terms of sperm counts and sperm quality, along with other changes in male reproductive health, including congenital malformations and testicular cancer in humans, and similar problems in wildlife has been correlated to the exposure to environmental contaminants.
  • Numerous studies demonstrate the interaction of environmental toxicants with steroid receptors and thereby causing interference with developmental and functional aspects of testis, epididymis and accessory sex organs.

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  • (PMID = 21783636.001).
  • [ISSN] 1382-6689
  • [Journal-full-title] Environmental toxicology and pharmacology
  • [ISO-abbreviation] Environ. Toxicol. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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59. Mechri M, Ghozzi S, Khiari R, Bougrine F, Bouziani A, Benrais N: A rare cause of a scrotal mass: primary leiomyosarcoma of epididymis. BMJ Case Rep; 2009;2009
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  • Most masses encountered within the scrotal sac are neoplastic and occur within the testis; however a subset (2-3%) of these tumours is extra-testicular and usually arises from paratesticular tissue.
  • Tumours occurring in the paratesticular region may be clinically indistinguishable from testicular tumours, thus resulting in initial misdiagnosis.
  • In addition, the clinical findings are by no means specific to a tumour type and cannot distinguish between a benign and a malignant tumour, which results in difficulty in diagnosis and management.
  • Definite diagnosis is determined by histological evaluation.Leiomyosarcoma, the second most common paratesticular sarcoma after liposarcoma, is represented in the literature primarily as case reports.
  • We report a case of LMS arising from the epididymis and focus on clinical presentation and differential diagnosis of such tumours.

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60. Puisac B, Arnedo M, Casale CH, Ribate MP, Castiella T, Ramos FJ, Ribes A, Pérez-Cerdá C, Casals N, Hegardt FG, Pié J: Differential HMG-CoA lyase expression in human tissues provides clues about 3-hydroxy-3-methylglutaric aciduria. J Inherit Metab Dis; 2010 Aug;33(4):405-10
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  • 3-Hydroxy-3-methylglutaric aciduria is a rare human autosomal recessive disorder caused by deficiency of 3-hydroxy-3-methylglutaryl CoA lyase (HL).
  • We measured mRNA levels, protein expression and enzyme activity of human HMG-CoA lyase from liver, kidney, pancreas, testis, heart, skeletal muscle, and brain.
  • [MeSH-minor] Aged. Brain / enzymology. Enzyme Activation. Humans. Kidney / enzymology. Liver / enzymology. Male. Muscle, Skeletal / enzymology. Myocardium / enzymology. Organ Specificity. Pancreas / enzymology. RNA, Messenger / metabolism. Testis / enzymology

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  • (PMID = 20532825.001).
  • [ISSN] 1573-2665
  • [Journal-full-title] Journal of inherited metabolic disease
  • [ISO-abbreviation] J. Inherit. Metab. Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Acids; 0 / RNA, Messenger; CLA99KCD53 / Meglutol; EC 4.1.3.- / Oxo-Acid-Lyases; EC 4.1.3.4 / 3-hydroxy-3-methylglutaryl-coenzyme A lyase
  • [Other-IDs] NLM/ PMC2903694
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61. Piprek RP: Genetic mechanisms underlying male sex determination in mammals. J Appl Genet; 2009;50(4):347-60
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  • Genetic control of gonadal development proceeds through either the male or female molecular pathways, driving bipotential gonadal anlage differentiation into a testis or ovary.
  • Sertoli cells orchestrate testicular differentiation.
  • [MeSH-minor] Animals. Disorders of Sex Development. Female. Fibroblast Growth Factor 9 / genetics. Fibroblast Growth Factor 9 / physiology. Genes, sry. Male. Models, Genetic. Ovary / embryology. Paracrine Communication. Prostaglandin D2 / physiology. SOX9 Transcription Factor / genetics. Sex Determination Processes. Testis / embryology. Transcription Factors / genetics

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  • (PMID = 19875885.001).
  • [ISSN] 1234-1983
  • [Journal-full-title] Journal of applied genetics
  • [ISO-abbreviation] J. Appl. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DMRT1 protein; 0 / Fibroblast Growth Factor 9; 0 / SOX9 Transcription Factor; 0 / Transcription Factors; RXY07S6CZ2 / Prostaglandin D2
  • [Number-of-references] 126
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62. Xu ZP, Sun HX, Zhang NY: [Sperm DNA damage and assisted reproductive technology]. Zhonghua Nan Ke Xue; 2008 Mar;14(3):259-63
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  • Some treatment strategies might reduce the percentage of sperm DNA damage and increase the success rate of ART, including oral administration of antioxygen drugs, ICSI with testis sperm, sperm freezing and preservation, removing of etiological factors, traditional Chinese medicine, and so on.

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  • (PMID = 18488344.001).
  • [ISSN] 1009-3591
  • [Journal-full-title] Zhonghua nan ke xue = National journal of andrology
  • [ISO-abbreviation] Zhonghua Nan Ke Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] China
  • [Number-of-references] 37
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63. Ishii T, Yanagawa T: Stress-induced peroxiredoxins. Subcell Biochem; 2007;44:375-84
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  • Gene expression of both Prx I and II is activated by X-ray irradiation of the testis.
  • [MeSH-minor] Animals. Cells, Cultured. Enzyme Activation / drug effects. Enzyme Activation / radiation effects. Female. Humans. Male. Mitochondrial Proteins / biosynthesis. Response Elements. Testis / metabolism. Transcriptional Activation. X-Rays

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  • (PMID = 18084904.001).
  • [ISSN] 0306-0225
  • [Journal-full-title] Sub-cellular biochemistry
  • [ISO-abbreviation] Subcell. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Mitochondrial Proteins; 0 / Transcription Factors; EC 1.11.1.15 / Peroxiredoxins
  • [Number-of-references] 34
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64. Sarkar NN: Intracytoplasmic sperm injection: an assisted reproductive technique and its outcome to overcome infertility. J Obstet Gynaecol; 2007 May;27(4):347-53
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  • Spermatozoa of infertile men are surgically retrieved from the epididymis or testis.

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  • (PMID = 17654183.001).
  • [ISSN] 0144-3615
  • [Journal-full-title] Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
  • [ISO-abbreviation] J Obstet Gynaecol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 50
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65. Hughes IA, Deeb A: Androgen resistance. Best Pract Res Clin Endocrinol Metab; 2006 Dec;20(4):577-98
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  • Partial resistance to androgens is a common cause of ambiguous genitalia of the newborn, but a similar phenotype may result from several other conditions, including defects in testis determination and androgen biosynthesis.
  • Management issues in syndromes of androgen insensitivity include decisions on sex assignment, timing of gonadectomy in relation to tumour risk, and genetic and psychological counselling.

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  • (PMID = 17161333.001).
  • [ISSN] 1521-690X
  • [Journal-full-title] Best practice & research. Clinical endocrinology & metabolism
  • [ISO-abbreviation] Best Pract. Res. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Androgens; 0 / Chorionic Gonadotropin; 0 / Receptors, Androgen; 3XMK78S47O / Testosterone; 9002-67-9 / Luteinizing Hormone; 9002-68-0 / Follicle Stimulating Hormone
  • [Number-of-references] 102
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66. Wang AG, Moon HB, Chun SY, Lee TH, Yu DY, Lee DS: Orchiectomy reduces hepatotumorigenesis of H-ras12V transgenic mice via the MAPK pathway. Life Sci; 2006 Oct 19;79(21):1974-80
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  • The pathological diagnosis, sex hormone levels, expression of the H-ras12V transgene, and ras related signal pathways were determined.
  • The present study demonstrates that testis-related factors play important roles in hepatotumorigenesis in H-ras12V transgenic mice.

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  • (PMID = 16846616.001).
  • [ISSN] 0024-3205
  • [Journal-full-title] Life sciences
  • [ISO-abbreviation] Life Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 3XMK78S47O / Testosterone; EC 2.7.11.24 / Mitogen-Activated Protein Kinases; EC 3.6.5.2 / ras Proteins
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67. Nakamoto M, Suzuki A, Matsuda M, Nagahama Y, Shibata N: Testicular type Sox9 is not involved in sex determination but might be in the development of testicular structures in the medaka, Oryzias latipes. Biochem Biophys Res Commun; 2005 Aug 5;333(3):729-36
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  • [Title] Testicular type Sox9 is not involved in sex determination but might be in the development of testicular structures in the medaka, Oryzias latipes.
  • Testicular type Sox9 is the most upstream conserved gene in the sex determining cascade among vertebrate.
  • However, in medaka, only one Sox9 gene was identified as expressed in the ovary; no other Sox9 gene was reported expressed in the testis.
  • We explored the medaka genome and cloned a novel testicular type Sox9 cDNA.
  • However, at the initial stage of testicular tubules development, the expression of Sox9a2 was maintained only in XY gonads, and was remarkably reduced in XX gonads.
  • These results suggest that Sox9a2 is not involved in early sex determination and differentiation, but is involved in the later development of testicular tubules in medaka.
  • [MeSH-major] High Mobility Group Proteins / genetics. Oryzias / embryology. Sex Determination Processes. Testis / embryology. Transcription Factors / genetics

  • ZFIN. ZFIN .
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  • (PMID = 15963466.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; 0 / High Mobility Group Proteins; 0 / SOX9 Transcription Factor; 0 / Transcription Factors
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68. Luboshits G, Benayahu D: MS-KIF18A, new kinesin; structure and cellular expression. Gene; 2005 May 23;351:19-28
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  • Transcripts derived from this gene were also detected in testis and trachea, although they differed from the stroma mesenchymal cell transcript in the open reading frame (ORF) as well as in the untranslated regions (UTRs).

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  • (PMID = 15878648.001).
  • [ISSN] 0378-1119
  • [Journal-full-title] Gene
  • [ISO-abbreviation] Gene
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AY791349
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Complementary; EC 3.6.1.- / KIF18A protein, human; EC 3.6.1.- / Kinesin
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69. Santiago-Moreno J, Gómez-Brunet A, González-Bulnes A, Toledano-Díaz A, Malpaux B, López-Sebastián A: Differences in reproductive pattern between wild and domestic rams are not associated with inter-specific annual variations in plasma prolactin and melatonin concentrations. Domest Anim Endocrinol; 2005 May;28(4):416-29
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  • This study compares morphological changes, performed with real-time transrectal ultrasonography, of testis and accessory glands and seasonal endocrine changes in a wild (Mouflon) and a domesticated (Spanish Merino) breed of sheep.
  • In Mouflons, the maximum plasma testosterone concentrations, testicular diameter and vesicular gland size occurred synchronously during autumn (P<0.001).
  • In Merino rams the highest circulating levels of testosterone (P<0.05) and maximum testicular diameter (P<0.001) occurred during summer, with no seasonal variations in vesicular and bulbourethral glands.
  • The seasonal changes in plasma concentrations of prolactin were not correlated with annual variations in testicular and glandular size in neither wild nor domestic species.
  • [MeSH-minor] Animals. Male. Seasons. Testis / physiology. Testis / ultrasonography. Testosterone / blood

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  • (PMID = 15826776.001).
  • [ISSN] 0739-7240
  • [Journal-full-title] Domestic animal endocrinology
  • [ISO-abbreviation] Domest. Anim. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 3XMK78S47O / Testosterone; 9002-62-4 / Prolactin; JL5DK93RCL / Melatonin
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70. Roy BC, Aoyagi T, Sarkar S, Nomura K, Kanda H, Iwaya K, Tachibana M, Kiyama R: Pathological characterization of Kank in renal cell carcinoma. Exp Mol Pathol; 2005 Feb;78(1):41-8
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  • The Kank gene was found as a candidate tumor suppressor gene at 9p24 by loss-of-heterozygosity search in renal cell carcinoma (RCC) and seems to have a role in controlling the formation of the cytoskeleton through the polymerization of actin.
  • Here, we characterized the Kank protein in renal tubular cells as well as other glandular cells in the colon, stomach, prostate, testis, pancreas, thyroid, uterus, submandibular gland, adrenal, duodenum, and esophagus, and specific cells such as hepatic, alveolar myocardial, and glial cells by using a monoclonal antibody against Kank.
  • [MeSH-major] Carcinoma, Renal Cell / genetics. Gene Expression Regulation, Neoplastic. Kidney Neoplasms / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Female. Humans. Immunoenzyme Techniques. Kidney Tubules / metabolism. Kidney Tubules / pathology. Loss of Heterozygosity. Male. Middle Aged. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Tumor Cells, Cultured

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  • (PMID = 15596059.001).
  • [ISSN] 0014-4800
  • [Journal-full-title] Experimental and molecular pathology
  • [ISO-abbreviation] Exp. Mol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / KANK1 protein, human; 0 / RNA, Messenger; 0 / Tumor Suppressor Proteins
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71. Ungerfeld R, González-Pensado SP: Social dominance and courtship and mating behaviour in rams in non-competitive and competitive pen tests. Reprod Domest Anim; 2009 Feb;44(1):44-7
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  • A group of 19 Merino rams was used to determine: (i) if body weight, age and testis characteristics are different between high (HR) and low-ranked (LR) rams, and (ii) how the competition between HR and LR rams for oestrous ewes affect their courtship and mating behaviour.
  • Hierarchy was determined using the food competition test.
  • The five first and five last ranked rams were individually exposed to oestrous ewes in pen tests, and the frequency of different courtship behavioural units, mounts and mates, and the time from test onset to each mate was recorded.
  • Age, body weight, body condition score, scrotal circumference, and testis firmness and resilience from HR and LR were not different.
  • The number of mates per test from HR rams was lower than that observed in LR rams when tested alone.
  • In summary, there was no relation between social rank and body weight, age or testis characteristics.
  • [MeSH-minor] Age Factors. Animals. Body Weight. Male. Scrotum / anatomy & histology. Testis / anatomy & histology. Testis / physiology

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  • (PMID = 18507799.001).
  • [ISSN] 1439-0531
  • [Journal-full-title] Reproduction in domestic animals = Zuchthygiene
  • [ISO-abbreviation] Reprod. Domest. Anim.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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72. Chen B, Guo JH, Lu YN, Ying XL, Hu K, Xiang ZQ, Wang YX, Chen P, Huang YR: Leptin and varicocele-related spermatogenesis dysfunction: animal experiment and clinical study. Int J Androl; 2009 Oct;32(5):532-41
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  • The expression of leptin and its receptor in the testis of rats was not related to the weight of rat, but was inversely related to the weight of testis (r = -0.408, p = 0.009 and r = -0.433, p = 0.005, respectively), the Johnsen scores (r = -0.916, p = 0.000 and r = -0.863, p = 0.000, respectively), the seminiferous tubules diameter (r = -0.853, p = 0.000 and r = -0.870, p = 0.000, respectively) and the thickness of seminiferous epithelium (r = -0.929, p = 0.000 and r = -0.948, p = 0.000, respectively).
  • Leptin may have local effects on the function of testis and spermatogenesis.
  • [MeSH-minor] Animals. Base Sequence. DNA Primers. Enzyme-Linked Immunosorbent Assay. Immunohistochemistry. Male. Rats. Rats, Sprague-Dawley. Reverse Transcriptase Polymerase Chain Reaction. Testis / pathology

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  • (PMID = 18484972.001).
  • [ISSN] 1365-2605
  • [Journal-full-title] International journal of andrology
  • [ISO-abbreviation] Int. J. Androl.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Leptin
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73. Michailova KN, Wassilev WA, Kühnel W: Features of the peritoneal covering of the lesser pelvis with special reference to stomata regions. Ann Anat; 2005 Mar;187(1):23-33
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  • The peritoneal covering of the urinary bladder, rectum, uterus, uterine tube, ovary, broad ligament (BL) and testis in Wistar rats was examined by means of transmission and scanning electron microscopy (TEM, SEM).
  • Such cells formed an almost smooth surface over the urinary bladder or formed larger areas of the rectum and the testis surfaces.
  • Clusters of cells (macrophages, mastocytes and Lymphocytes), small vessels (blood or lymphatic) and nerve fibers (unmyelinated and rare myelinated) form highly specialized complexes in the SML of the ovary, the uterus and the testis.
  • [MeSH-minor] Animals. Female. Ligaments / ultrastructure. Male. Microscopy, Electron, Scanning. Ovary / ultrastructure. Pelvis. Rats. Rats, Wistar. Rectum / ultrastructure. Testis / ultrastructure. Urinary Bladder / ultrastructure. Uterus / ultrastructure

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  • (PMID = 15835397.001).
  • [ISSN] 0940-9602
  • [Journal-full-title] Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft
  • [ISO-abbreviation] Ann. Anat.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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74. Zeng W, Snedaker AK, Megee S, Rathi R, Chen F, Honaramooz A, Dobrinski I: Preservation and transplantation of porcine testis tissue. Reprod Fertil Dev; 2009;21(3):489-97
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  • [Title] Preservation and transplantation of porcine testis tissue.
  • Grafting of immature mammalian testis tissue to mouse hosts can preserve the male germline.
  • To make this approach applicable to a clinical or field situation, it is imperative that the testis tissue and/or spermatozoa harvested from grafted tissue are preserved successfully.
  • The aim of the present study was to evaluate protocols for the preservation of testis tissue in a porcine model.
  • Testis tissue was stored at 4 degrees C for short-term preservation or cryopreserved by slow-freezing, automated slow-freezing or vitrification for long-term storage.
  • Therefore, it is important to evaluate germ cell differentiation in vivo in addition to cell viability in vitro when optimising freezing protocols for testis tissue.

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  • (PMID = 19261226.001).
  • [ISSN] 1031-3613
  • [Journal-full-title] Reproduction, fertility, and development
  • [ISO-abbreviation] Reprod. Fertil. Dev.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / R01 RR017359; United States / NCRR NIH HHS / RR / RR017359-07; United States / NCRR NIH HHS / RR / R01 RR017359-07; United States / NCRR NIH HHS / RR / R01 RR17359-05
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Australia
  • [Other-IDs] NLM/ NIHMS105422; NLM/ PMC2669893
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75. Kashimada K, Koopman P: Sry: the master switch in mammalian sex determination. Development; 2010 Dec;137(23):3921-30
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  • SRY, the mammalian Y-chromosomal testis-determining gene, induces male sex determination.
  • Recent studies in mice reveal that the major role of SRY is to achieve sufficient expression of the related gene Sox9, in order to induce Sertoli cell differentiation, which in turn drives testis formation.

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  • (PMID = 21062860.001).
  • [ISSN] 1477-9129
  • [Journal-full-title] Development (Cambridge, England)
  • [ISO-abbreviation] Development
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Sex-Determining Region Y Protein
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76. McClusky LM: Cadmium accumulation and binding characteristics in intact Sertoli/germ cell units, and associated effects on stage-specific functions in vitro: insights from a shark testis model. J Appl Toxicol; 2008 Mar;28(2):112-21
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  • [Title] Cadmium accumulation and binding characteristics in intact Sertoli/germ cell units, and associated effects on stage-specific functions in vitro: insights from a shark testis model.
  • The testis is sensitive to Cd because of the steroid-mediated regulation of spermatogenesis, high levels of DNA synthesis and gene transcription, all of which varies in a stage-related manner.
  • Validated techniques (acridine orange vital staining to detect apoptosis and dextran-rhodamine exclusion to assess blood-testis barrier function) were recently developed and the shark testis was proposed as an alternative model for assessing stage-specific functions in living testicular tissue and to study toxicant actions on spermatogenesis.
  • Although Cd uptake in PoM cysts was more than 2-fold less than uptake in PrM cysts, the percentage dextran-rhodamine permeant PoM cysts was approximately 8-fold greater than in controls in the presence of both 10 microm CdCl2 and 30 microm CdCl2 after 4 days culture, indicating that blood-testis barrier function in PoM spermatocysts was compromised.
  • [MeSH-major] Blood-Testis Barrier / metabolism. Cadmium Chloride / metabolism. Environmental Pollutants / metabolism. Sertoli Cells / metabolism. Spermatozoa / metabolism. Squalus acanthias / metabolism. Testis / metabolism. Toxicity Tests / methods

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  • (PMID = 17557368.001).
  • [ISSN] 0260-437X
  • [Journal-full-title] Journal of applied toxicology : JAT
  • [ISO-abbreviation] J Appl Toxicol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cadmium Radioisotopes; 0 / Environmental Pollutants; J6K4F9V3BA / Cadmium Chloride
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77. Fecteau KA, Mrkonjich L, Mason JI, Mendis-Handagama SM: Detection of platelet-derived growth factor-alpha (PDGF-A) protein in cells of Leydig lineage in the postnatal rat testis. Histol Histopathol; 2006 12;21(12):1295-302
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  • [Title] Detection of platelet-derived growth factor-alpha (PDGF-A) protein in cells of Leydig lineage in the postnatal rat testis.
  • Platelet-derived growth factor-A (PDGF-A) is a locally produced growth factor in the rat testis secreted by both Sertoli cells and Leydig cells.
  • It has been suggested that PDGF-A may be involved in modulation of testosterone production and may be essential to Leydig cell differentiation, however it is not known at what stage of differentiation PDGF-A begins to be expressed in the cells of Leydig lineage in the postnatal rat testis.
  • These cells were confirmed to be the progenitor cells and not the mesenchymal or any other spindle-shaped cells in the testis interstitium by immunolocalization of 3beta-HSD and PDGF-A in the cells in adjacent sections of testis tissue from rats of postnatal days 10-14.
  • After postnatal day 10, PDGF-A was continued to be expressed in subsequent cells of the Leydig lineage through day 90 (adult), however, was not present in peritubular mesenchymal precursor cells of the Leydig cell lineage or any other spindle-shaped cells in the testis interstitium at any tested age.
  • These results revealed that PDGF-A first appears in Leydig progenitor cells in the postnatal rat testis at the onset of mesenchymal cell differentiation into progenitor cells at postnatal day 10 and suggest that a functional role(s) of PDGF-A in postnatally differentiated Leydig cells in the rat testis is established at the time of the onset of postnatal Leydig stem cell differentiation.
  • [MeSH-major] Leydig Cells / secretion. Platelet-Derived Growth Factor / analysis. Testis / cytology

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  • (PMID = 16977580.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Platelet-Derived Growth Factor; 0 / platelet-derived growth factor A
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78. Jabbour SK, Zhang Z, Arnold D, Wharam MD: Risk of second tumor in intracranial germinoma patients treated with radiation therapy: the Johns Hopkins experience. J Neurooncol; 2009 Jan;91(2):227-32
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  • [Title] Risk of second tumor in intracranial germinoma patients treated with radiation therapy: the Johns Hopkins experience.
  • BACKGROUND: We reviewed the risk of second tumor (ST), both malignant and benign, in germinoma survivors followed at the Johns Hopkins Hospital (JHH).
  • In the presence of competing events, a cumulative incidence function of ST was estimated using the minimal time interval from the date of diagnosis to the date of ST, date of death, or date of last follow-up.
  • One developed a benign falcine meningioma.
  • CONCLUSIONS: The relative contributions of RT and patient susceptibility to a ST cannot be determined but suggests the need for long-term surveillance, including testicular self-exams in male germinoma survivors.

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  • (PMID = 18813873.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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79. Naouar S, Maazoun K, Sahnoun L, Mekki M, Belghith M, Nouri A: [Polyorchidism: report of 2 cases and review of the literature]. Prog Urol; 2007 Sep;17(5):1008-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] La polyorchidie: a propos de 2 cas.
  • The authors report two cases in children aged 3 years and 5 years with left ectopic testis.
  • Surgical exploration demonstrated two testes on the left side with a third testis on the right.
  • [MeSH-major] Choristoma. Testis / pathology

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  • (PMID = 17969810.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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80. Raveendra A, Ampasala DR, Sandhya D, Thyagaraju K: Oral administration of Azadirachta indica (L.) seed kernel active principle protects rat liver hepatocytes and testis seminiferous tubules from phenobarbitol-induced damage. J Herb Pharmacother; 2007;7(3-4):259-66
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  • [Title] Oral administration of Azadirachta indica (L.) seed kernel active principle protects rat liver hepatocytes and testis seminiferous tubules from phenobarbitol-induced damage.
  • The male albino rat testis and liver showed tissue modification upon exposure to phenobarbitol (PB), 24 mg/100 g of body weight, for about 3 weeks and upon staining of their sections with hematoxylin and eosin.
  • The control rat testis showed epithelial layer having broad seminiferous tubules, spermatids, mature spermatozoa, and lumen of seminiferous tubules, and the PB-treated rat testis showed degenerative and necrotic changes in seminiferous tubules and clumping of seminiferous tubules.
  • These changes almost returned to normal conditions in rat liver and testis upon the oral administration of an antioxidant that is present in Azadirachta seed-kernel extract (ASKE, 100 mg/kg body weight).
  • The lipid peroxides were reduced in all the three cases in both liver and testis.
  • The histological studies and enzymatic analysis revealed that the potential role of ASKE in the protection of the testis and liver tissues from PB-induced damage.
  • [MeSH-major] Azadirachta. Hepatocytes / drug effects. Phenobarbital / adverse effects. Phytotherapy / methods. Plant Extracts / pharmacology. Protective Agents / pharmacology. Seminiferous Tubules / drug effects. Testis / drug effects

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  • (PMID = 18928146.001).
  • [ISSN] 1522-8940
  • [Journal-full-title] Journal of herbal pharmacotherapy
  • [ISO-abbreviation] J Herb Pharmacother
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Plant Extracts; 0 / Protective Agents; YQE403BP4D / Phenobarbital
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81. Mazhari M, Skordilis K, Pearce I: Inflammatory pseudotumour of the testis in an HIV patient. Histopathology; 2006 Apr;48(5):616-7
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  • [Title] Inflammatory pseudotumour of the testis in an HIV patient.
  • [MeSH-major] Genital Diseases, Male / pathology. Granuloma, Plasma Cell / pathology. HIV Infections / complications. Testis / pathology

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  • (PMID = 16623794.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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82. Lin CJ, Wu GC, Lee MF, Lau EL, Dufour S, Chang CF: Regulation of two forms of gonadotropin-releasing hormone receptor gene expression in the protandrous black porgy fish, Acanthopagrus schlegeli. Mol Cell Endocrinol; 2010 Jul 29;323(2):137-46
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  • The relative expressions of GnRH-Rs in the pituitary and gonad were as follows: pituitary: GnRH-R I > GnRH-R II; testicular tissue: GnRH-R I > GnRH-R II; ovarian tissue: GnRH-R I = GnRH-R II.
  • In vivo, hCG stimulated GnRH-R I and GnRH-R II expression in testis and ovary.
  • The LHRH analog also up-regulated both receptors in testis and but increased only GnRH-R II in the ovary.
  • Sex steroids (estradiol, E2 and testosterone, T) increased the expression of both receptors in the testis and ovary.

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  • [Copyright] 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20398731.001).
  • [ISSN] 1872-8057
  • [Journal-full-title] Molecular and cellular endocrinology
  • [ISO-abbreviation] Mol. Cell. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Protein Isoforms; 0 / Receptors, LHRH; 33515-09-2 / Gonadotropin-Releasing Hormone; 3XMK78S47O / Testosterone; 4TI98Z838E / Estradiol
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83. Anatol TI, Williams G, Adogwa A: A comparative study of different methods of orchidometry in a canine model. Int Urol Nephrol; 2006;38(3-4):647-52
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  • PURPOSE: An investigation was carried out to compare the testicular volumes obtained by different methods of assessment in a series of dogs.
  • A Prader orchidometer, which consists of a series of ovoid model testes inscribed with corresponding equivalent volumes, was used as an indirect method of assessing the volume of each testis.
  • Percutaneous measurements of length and width of each testis were also carried out prior to surgery under general anaesthesia, using both a sliding and a pinch type caliper.
  • After each testis was removed it was isolated and submerged in a beaker containing water in order to get a direct estimate of its volume by fluid displacement.
  • CONCLUSION: Estimates of testicular volumes obtained by orchidometer and pinch type caliper are useful for situations where a qualitative rather than quantitative assessment of testicular volume is required.
  • [MeSH-major] Testis / anatomy & histology

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84. Golestaneh N, Kokkinaki M, Pant D, Jiang J, DeStefano D, Fernandez-Bueno C, Rone JD, Haddad BR, Gallicano GI, Dym M: Pluripotent stem cells derived from adult human testes. Stem Cells Dev; 2009 Oct;18(8):1115-26
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  • We obtained testes from organ donors and using 1 g pieces of tissue (biopsy size) we demonstrate that testis germ cells (putative SSCs and/or their progenitors) reprogram to pluripotency when removed from their stem cell niche and when appropriate growth factors and reagents in embryonic stem cell medium are added.
  • [MeSH-major] Adult Stem Cells / cytology. Cell Differentiation. Cell Separation / methods. Pluripotent Stem Cells / cytology. Testis / cytology

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  • (PMID = 19281326.001).
  • [ISSN] 1557-8534
  • [Journal-full-title] Stem cells and development
  • [ISO-abbreviation] Stem Cells Dev.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / R01 HD033728
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3584510
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85. Kira S, Miyakawa H, Mori M, Hidaka S, Noguchi T, Fujisawa H: [Airway access using an endotracheal tube changer for safe extubation in an infant with a difficult airway]. Masui; 2008 Feb;57(2):167-70
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  • A 4-month-old male infant with bilateral cleft lip and palate, micrognathia, schizencephaly, undescended testis, and abnormality of chromosomes 10 was scheduled for bilateral cleft lip repair.

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  • (PMID = 18277563.001).
  • [ISSN] 0021-4892
  • [Journal-full-title] Masui. The Japanese journal of anesthesiology
  • [ISO-abbreviation] Masui
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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86. Rohrer GA, Wise TH, Ford JJ: Deciphering the pig genome to understand gamete production. Soc Reprod Fertil Suppl; 2006;62:293-301
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  • In the area of pig reproduction, a number of genome scans have identified several genomic regions associated with variation in reproductive measures ranging from ovulation rate, litter size and testis size.
  • [MeSH-minor] Animals. Female. Genetic Markers. Litter Size / genetics. Male. Ovulation / genetics. Testis / anatomy & histology

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  • (PMID = 16866325.001).
  • [ISSN] 1747-3403
  • [Journal-full-title] Society of Reproduction and Fertility supplement
  • [ISO-abbreviation] Soc Reprod Fertil Suppl
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Genetic Markers
  • [Number-of-references] 54
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87. Chen H, Xia T, Zhou L, Chen X, Gan L, Yao W, Peng Y, Yang Z: Gene organization, alternate splicing and expression pattern of porcine visfatin gene. Domest Anim Endocrinol; 2007 Apr;32(3):235-45
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  • Nested PCR showed that variants 1 and 3 were ubiquitously expressed in porcine tissues and that variant 2 was expressed in most tissues examined with exception of testis and liver.

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  • (PMID = 16857338.001).
  • [ISSN] 0739-7240
  • [Journal-full-title] Domestic animal endocrinology
  • [ISO-abbreviation] Domest. Anim. Endocrinol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ DQ001974
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytokines
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88. Su MT, Lee IW, Kuo PL: Presence of TSPY transcript and absence of transcripts of other Y chromosomal genes in a case of microscopic gonadoblastoma. Gynecol Oncol; 2006 Oct;103(1):357-60
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  • Testis-specific protein Y-encoded (TSPY) gene may participate in the oncogenesis of gonadoblastoma expression of TSPY in the tumor tissue.
  • We tested transcripts of 14 Y chromosomal genes by RT-PCR (TSPY, DAZ, BPY1 and BPY2, PRY, XKRY, CDY1 and CDY2, TTY1 and TTY2, PRKY, RBMY1, DBY and USP9Y), and only transcript of TSPY was detectable in the tumor tissue.

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  • (PMID = 16784771.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / RNA, Messenger; 0 / TSPY1 protein, human
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89. Katsu Y, Myburgh J, Kohno S, Swan GE, Guillette LJ Jr, Iguchi T: Molecular cloning of estrogen receptor alpha of the Nile crocodile. Comp Biochem Physiol A Mol Integr Physiol; 2006 Mar;143(3):340-6
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  • Expression of ERalpha was observed in the ovary and testis of juvenile Nile crocodiles.

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  • (PMID = 16455277.001).
  • [ISSN] 1095-6433
  • [Journal-full-title] Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
  • [ISO-abbreviation] Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha
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90. Cools M, Honecker F, Stoop H, Veltman JD, de Krijger RR, Steyerberg E, Wolffenbuttel KP, Bokemeyer C, Lau YF, Drop SL, Looijenga LH: Maturation delay of germ cells in fetuses with trisomy 21 results in increased risk for the development of testicular germ cell tumors. Hum Pathol; 2006 Jan;37(1):101-11
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  • [Title] Maturation delay of germ cells in fetuses with trisomy 21 results in increased risk for the development of testicular germ cell tumors.
  • Prolonged expression of octamer binding transcription factor 3/4, in combination with an increased expression of testis-specific protein, Y-encoded, might have pathogenetic relevance for the development of testicular germ cell tumors in this population.
  • [MeSH-major] Down Syndrome / complications. Fetal Development. Germ Cells / growth & development. Gonads / growth & development. Neoplasms, Germ Cell and Embryonal / complications. Testicular Neoplasms / complications

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  • (PMID = 16360422.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Cell Cycle Proteins; 0 / Octamer Transcription Factor-3; 0 / TSPY1 protein, human
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91. Imai S, Koyama J, Fujii K: Effects of 17beta-estradiol on the reproduction of Java-medaka (Oryzias javanicus), a new test fish species. Mar Pollut Bull; 2005;51(8-12):708-14
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  • [Title] Effects of 17beta-estradiol on the reproduction of Java-medaka (Oryzias javanicus), a new test fish species.
  • Thirty-three and sixty percent of male fishes exposed to 159 and 243 ng/l, respectively, had testis-ova.

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  • (PMID = 16291186.001).
  • [ISSN] 0025-326X
  • [Journal-full-title] Marine pollution bulletin
  • [ISO-abbreviation] Mar. Pollut. Bull.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 4TI98Z838E / Estradiol
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92. Guy JL, Lambert DW, Warner FJ, Hooper NM, Turner AJ: Membrane-associated zinc peptidase families: comparing ACE and ACE2. Biochim Biophys Acta; 2005 Aug 1;1751(1):2-8
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  • In contrast to the relatively ubiquitous angiotensin-converting enzyme (ACE), expression of the mammalian ACE homologue, ACE2, was initially described in the heart, kidney and testis.

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  • (PMID = 16054014.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Angiotensin-Converting Enzyme Inhibitors; 0 / Drosophila Proteins; 0 / Membrane Glycoproteins; 0 / Receptors, Virus; EC 3.4.- / Ance protein, Drosophila; EC 3.4.- / Carboxypeptidases; EC 3.4.15.1 / Peptidyl-Dipeptidase A; EC 3.4.17.- / angiotensin converting enzyme 2; EC 3.4.24.- / Metalloendopeptidases
  • [Number-of-references] 38
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93. Kokk K, Veräjänkorva E, Wu XK, Tapfer H, Põldoja E, Simovart HE, Pöllänen P: Expression of insulin signaling transmitters and glucose transporters at the protein level in the rat testis. Ann N Y Acad Sci; 2007 Jan;1095:262-73
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  • [Title] Expression of insulin signaling transmitters and glucose transporters at the protein level in the rat testis.
  • The aim of the present article is to demonstrate the distribution of IRS 1-3, glucose transporters 1-4 (GLUT 1-4), signal regulatory protein 1alpha (SIRP1alpha), PKB, and PI 3-kinase in the rat testis to see if signal transduction mediated by these proteins is active in testicular cells.
  • Wistar rats were used as donors of testis tissue.
  • IRS-1, IRS-2, GLUT 1, GLUT 2, GLUT 3, and SIRP1alpha were strongly expressed in the Sertoli cells (except GLUT 1), early spermatocytes, peritubular myoid cells, macrophage-like interstitial cells, and testicular endothelial cells in all the testes investigated by immunohistochemistry.
  • The present results suggest that proteins like insulin and certain cytokines using IRS-1, IRS-2, GLUT 1, GLUT 2, GLUT 3, PKB, and SIRP1alpha in their signal transduction can have effects on the different types of testicular cells in the rat.
  • [MeSH-major] Glucose / metabolism. Glucose Transport Proteins, Facilitative / genetics. Insulin / physiology. Signal Transduction / physiology. Testis / metabolism

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  • (PMID = 17404039.001).
  • [ISSN] 0077-8923
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glucose Transport Proteins, Facilitative; 0 / Insulin; 0 / Insulin Receptor Substrate Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / Irs1 protein, rat; 0 / Irs2 protein, rat; 0 / Irs3 protein, rat; 0 / Phosphoproteins; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; IY9XDZ35W2 / Glucose
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94. Matoba S, Kanai Y, Kidokoro T, Kanai-Azuma M, Kawakami H, Hayashi Y, Kurohmaru M: A novel Sry-downstream cellular event which preserves the readily available energy source of glycogen in mouse sex differentiation. J Cell Sci; 2005 Apr 1;118(Pt 7):1449-59
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  • Sry is transiently activated in pre-Sertoli cells of the gonadal ridge to initiate testis differentiation in mice.
  • Here we show that testis-specific glycogen accumulation in pre-Sertoli cells is one of the earliest cellular events downstream of Sry action.
  • In vitro analyses using various culture conditions suggest that testis-specific glycogen deposition is a tissue-autonomous event that can be induced even in serum-free conditions and in a culture of gonadal explants without adjacent mesonephros.
  • Active phospho-AKT (PI3K effector) showed a high degree of accumulation in gonadal somatic cells of genital ridges in a testis-specific manner, both in vitro and in vivo.
  • Therefore, these findings suggest that immediately after the onset of Sry expression, activation of the PI3K-AKT pathway promotes testis-specific glycogen storage in pre-Sertoli cells.
  • To the best of our knowledge, this is a novel Sry-downstream cellular event which preserves this readily available energy source in Sertoli cells for testis-specific morphogenesis and hormone production.
  • [MeSH-minor] Animals. Busulfan / pharmacology. Chromones / pharmacology. Enzyme Inhibitors / pharmacology. Female. Injections, Intraperitoneal. Male. Mice. Mice, Inbred ICR. Mice, Transgenic. Morpholines / pharmacology. Organ Culture Techniques / methods. Organ Specificity / physiology. Sertoli Cells / metabolism. Sex Characteristics. Sex Determination Analysis. Sex-Determining Region Y Protein. Signal Transduction / drug effects. Signal Transduction / physiology. Testis / embryology. Testis / metabolism. Testis / ultrastructure

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  • (PMID = 15769848.001).
  • [ISSN] 0021-9533
  • [Journal-full-title] Journal of cell science
  • [ISO-abbreviation] J. Cell. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chromones; 0 / DNA-Binding Proteins; 0 / Enzyme Inhibitors; 0 / Morpholines; 0 / Nuclear Proteins; 0 / Sex-Determining Region Y Protein; 0 / Sry protein, mouse; 0 / Transcription Factors; 154447-36-6 / 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; 9005-79-2 / Glycogen; G1LN9045DK / Busulfan
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95. Cavaco JE, Laurentino SS, Barros A, Sousa M, Socorro S: Estrogen receptors alpha and beta in human testis: both isoforms are expressed. Syst Biol Reprod Med; 2009 Aug;55(4):137-44
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  • [Title] Estrogen receptors alpha and beta in human testis: both isoforms are expressed.
  • The expression of estrogen receptor alpha (ERalpha) and beta (ERbeta) in human testis has been described.
  • However, some studies were unable to detect ERalpha, while others report the expression of both isoforms, with ERbeta presenting a wide distribution within somatic and germinal testicular cells.
  • This has suggested that estrogens may exert their testicular effects exclusively through ERbeta.
  • The present work aims to study the expression of ERalpha and ERbeta in testicular biopsies of men with conserved and disrupted spermatogenesis, in order to better clarify the positive cell populations.
  • Human testicular tissue was obtained from 10 men undergoing testicular biopsy for infertility relief due to azoospermia: two patients had secondary obstructive azoospermia with conserved spermatogenesis, five had Sertoli cell-only syndrome, two had hypospermatogenesis and one had meiotic arrest.
  • This study demonstrates ERalpha mRNA expression in human testis and describes its localization in somatic and germ cell subtypes.
  • These findings suggest that both ER isoforms are involved in the control of testicular function.
  • [MeSH-major] Azoospermia / metabolism. Estrogen Receptor alpha / metabolism. Estrogen Receptor beta / metabolism. Germ Cells / metabolism. Testis / metabolism

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  • (PMID = 19886769.001).
  • [ISSN] 1939-6376
  • [Journal-full-title] Systems biology in reproductive medicine
  • [ISO-abbreviation] Syst Biol Reprod Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; 0 / Estrogen Receptor beta; 0 / Protein Isoforms; 0 / RNA, Messenger
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96. Zhang W, Xia XY, Ding H, Liu P, Cai H, Li P, Xu C, Li Z: [Establishment of recipient mouse model of stem cell transplantation into testicular seminiferous tubules and improvement of transplantation techniques]. Zhonghua Nan Ke Xue; 2009 Aug;15(8):703-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Establishment of recipient mouse model of stem cell transplantation into testicular seminiferous tubules and improvement of transplantation techniques].
  • The survival rate was recorded every day, and the testis weight and spermatogenesis of testicular tubules were determined at 4, 8 and 12 weeks after the injection.
  • At 4 weeks after Busulfan treatment, the testis weight decreased apparently in Groups A, B and C, with significant differences from D (P < 0.05).
  • The improved transplantation device increased the success rate (> 90%), lowered the donor cell loss (< 50 microl cell suspension needed for both testes) and shortened the process ( < 10 min for one testis).
  • [MeSH-major] Disease Models, Animal. Seminiferous Tubules / cytology. Stem Cell Transplantation / methods. Testis

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  • (PMID = 19852270.001).
  • [ISSN] 1009-3591
  • [Journal-full-title] Zhonghua nan ke xue = National journal of andrology
  • [ISO-abbreviation] Zhonghua Nan Ke Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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97. Liu H, Li S, Zhang Y, Yan Y, Li Y: Dynamic regulation of glutamic acid decarboxylase 65 gene expression in rat testis. Acta Biochim Biophys Sin (Shanghai); 2009 Jul;41(7):545-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dynamic regulation of glutamic acid decarboxylase 65 gene expression in rat testis.
  • Here, by rapid amplification of cDNA ends method, two distinct GAD65 mRNA isoforms transcribed from two independent clusters of transcription start sites were identified in post-natal rat testis.
  • RT-PCR results revealed that the two mRNA isoforms had distinct expression patterns during post-natal testis maturation, suggesting that GAD65 gene expression was regulated by alternative promoters at the transcription level.
  • By using GAD65-specific antibodies, western blotting analysis showed that the 58-kDa GAD65, N-terminal 69 amino acids truncated form of full-length GAD65 protein, was developmentally expressed during post-natal testis maturation, suggesting that GAD65 gene expression in testis may also be regulated by post-translational processing.
  • Confocal immunofluorescence microscopy revealed that GAD65 protein was presented in Leydig cells of Day 1 testis, primary spermatocytes and spermatids of postnatal of Day 90 testis.
  • The above results suggested that GAD65 gene expression is dynamically regulated at multiple levels during post-natal testis maturation.
  • [MeSH-major] Gene Expression Regulation, Enzymologic. Glutamate Decarboxylase / genetics. Testis / enzymology

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  • (PMID = 19578718.001).
  • [ISSN] 1745-7270
  • [Journal-full-title] Acta biochimica et biophysica Sinica
  • [ISO-abbreviation] Acta Biochim. Biophys. Sin. (Shanghai)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Isoenzymes; EC 4.1.1.15 / Glutamate Decarboxylase; EC 4.1.1.15 / glutamate decarboxylase 2
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98. Thuillier R, Manku G, Wang Y, Culty M: Changes in MAPK pathway in neonatal and adult testis following fetal estrogen exposure and effects on rat testicular cells. Microsc Res Tech; 2009 Nov;72(11):773-86
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Changes in MAPK pathway in neonatal and adult testis following fetal estrogen exposure and effects on rat testicular cells.
  • In the present study, we examined the effects of fetal exposure to genistein and BPA on the Mitogen-activated protein kinase (MAPK) pathway and on testicular cell populations in neonatal and adult rat testes.
  • Transient effects were observed on germ cell populations, while the only remaining effect on adult testicular cells was an increase in Leydig cell number.
  • [MeSH-major] Estrogens / pharmacology. Leydig Cells / drug effects. Mitogen-Activated Protein Kinases / metabolism. Sertoli Cells / drug effects. Spermatocytes / drug effects. Spermatogonia / drug effects. Testis / drug effects

  • COS Scholar Universe. author profiles.
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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19565636.001).
  • [ISSN] 1097-0029
  • [Journal-full-title] Microscopy research and technique
  • [ISO-abbreviation] Microsc. Res. Tech.
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / ES 10366
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzhydryl Compounds; 0 / Estrogens; 0 / Phenols; DH2M523P0H / Genistein; EC 2.7.11.24 / Mitogen-Activated Protein Kinases; MLT3645I99 / bisphenol A
  • [Number-of-references] 60
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99. Sriraman V, Anbalagan M, Rao AJ: Hormonal regulation of Leydig cell proliferation and differentiation in rodent testis: a dynamic interplay between gonadotrophins and testicular factors. Reprod Biomed Online; 2005 Oct;11(4):507-18
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hormonal regulation of Leydig cell proliferation and differentiation in rodent testis: a dynamic interplay between gonadotrophins and testicular factors.
  • [MeSH-major] Gonadotropins / metabolism. Leydig Cells / cytology. Testis / cytology. Testis / metabolism. Testis / pathology

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  • (PMID = 16274617.001).
  • [ISSN] 1472-6483
  • [Journal-full-title] Reproductive biomedicine online
  • [ISO-abbreviation] Reprod. Biomed. Online
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Estrogens; 0 / Gonadotropins; 0 / Mesylates; 4672-49-5 / ethylene dimethanesulfonate; 67763-96-6 / Insulin-Like Growth Factor I; 9002-67-9 / Luteinizing Hormone; 9002-68-0 / Follicle Stimulating Hormone
  • [Number-of-references] 115
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100. de Gier RP: [The non-scrotal testes: current standpoints of the Paediatric Urology Workgroup of the Dutch Urological Association]. Ned Tijdschr Geneeskd; 2008 Jul 19;152(29):1606-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] De niet-scrotale testis: huidige standpunten van de Werkgroep Kinderurologie van de Nederlandse Vereniging voor Urologie.
  • However, the fact that recent studies show a diminished risk for testicular cancer if orchiopexia is performed before puberty, is a strong argument to not postpone orchiopexia until puberty or later, even if a significant proportion of these testes will descend around puberty.
  • In addition, it has not been proven that the non-scrotal position, of an acquired NST for a number of years, has no deleterious effects on the testis and its later fertility potential.
  • [MeSH-major] Cryptorchidism / surgery. Puberty / physiology. Scrotum / surgery. Testis / growth & development

  • MedlinePlus Health Information. consumer health - Puberty.
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  • [CommentIn] Ned Tijdschr Geneeskd. 2008 Nov 15;152(46):2534; author reply 2534 [19055262.001]
  • [CommentOn] Ned Tijdschr Geneeskd. 2008 Feb 2;152(5):243-5 [18333537.001]
  • [CommentOn] Ned Tijdschr Geneeskd. 2008 Feb 2;152(5):246-52 [18333538.001]
  • (PMID = 18998266.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Comment; English Abstract; Journal Article
  • [Publication-country] Netherlands
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