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1. Uehara T, Sawada M: Struma ovarii associated with Meigs syndrome. Jpn J Clin Oncol; 2007 Jan;37(1):73
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  • [Title] Struma ovarii associated with Meigs syndrome.
  • [MeSH-major] Meigs Syndrome / pathology. Meigs Syndrome / radiography. Struma Ovarii / pathology. Struma Ovarii / radiography

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  • (PMID = 17272322.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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2. Brogioni S, Viacava P, Tomisti L, Martino E, Macchia E: A special case of bilateral ovarian metastases in a woman with papillary carcinoma of the thyroid. Exp Clin Endocrinol Diabetes; 2007 Jun;115(6):397-400
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  • [Title] A special case of bilateral ovarian metastases in a woman with papillary carcinoma of the thyroid.
  • Papillary thyroid carcinoma is a slow growing tumor with low metastatic potential.
  • Ovarian metastases from papillary thyroid carcinoma are exceptional.
  • We describe a case of bilateral ovarian metastases from a papillary thyroid carcinoma associated with autoimmune thyroiditis in a 38-year-old woman who underwent thyroidectomy and cervical lymph-node dissection 7 years before, followed by 948 mCi of 131I.
  • A primary ovarian cancer could be excluded by the typical pathological aspects of a papillary thyroid carcinoma in a context of an aggressive form of thyroid cancer.
  • On the other hand, the clinical history and the absence of normal thyroid epithelium and teratomatous components could exclude a papillary thyroid carcinoma arising in struma ovarii.
  • This is a singular case of papillary thyroid carcinoma metastasizing to the ovary, combined with an autoimmune thyroiditis.
  • [MeSH-major] Carcinoma, Papillary / pathology. Ovarian Neoplasms / pathology. Ovarian Neoplasms / secondary. Thyroid Neoplasms / pathology

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  • (PMID = 17701887.001).
  • [ISSN] 0947-7349
  • [Journal-full-title] Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
  • [ISO-abbreviation] Exp. Clin. Endocrinol. Diabetes
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 13
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3. Coyne C, Nikiforov YE: RAS mutation-positive follicular variant of papillary thyroid carcinoma arising in a struma ovarii. Endocr Pathol; 2010 Jun;21(2):144-7
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  • [Title] RAS mutation-positive follicular variant of papillary thyroid carcinoma arising in a struma ovarii.
  • Struma ovarii is an ovarian mature teratoma composed exclusively or predominantly of thyroid tissue.
  • Malignant transformation of struma ovarii is rare and poorly understood, although this process is thought to be similar to carcinogenesis in malignant tumors of differentiated thyroid tissue originating in the thyroid gland.
  • Genetic alterations in the mitogen-activated protein kinase pathway, including mutations of BRAF, RAS, and RET genes, have been implicated in the development of differentiated thyroid carcinoma arising in the thyroid gland.
  • We report here a case with RAS mutation detected in a malignant struma ovarii.
  • The patient is a 38-year-old female who had a 2.4 cm ovarian cyst noted incidentally on a first trimester ultrasound.
  • She proceeded to ovarian cystectomy post-delivery, with pathologic examination detecting a papillary thyroid carcinoma, follicular variant, arising in a cystic teratoma.
  • The tumor was tested for BRAF, RAS, and RET/PTC mutations.
  • This is the first report of RAS mutation detected in the follicular variant of papillary carcinoma arising in a struma ovarii.
  • It provides evidence that tumors developing in this setting involve molecular mechanisms similar to those implicated in tumors developing in the thyroid gland.
  • [MeSH-major] Adenocarcinoma, Papillary / genetics. Neoplasms, Multiple Primary / genetics. Ovarian Neoplasms / genetics. Struma Ovarii / genetics. Thyroid Neoplasms / genetics. ras Proteins / genetics

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  • (PMID = 19898969.001).
  • [ISSN] 1559-0097
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / RET protein, human; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / ras Proteins
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4. Sibio S, Borrini F, Sammartino P, Accarpio F, Biacchi D, Caprio G, Iafrate F, Baccheschi AM, Cornali T, Di Giorgio A: Predominant Brenner tumor combined with struma ovarii containing a papillary microcarcinoma associated with benign peritoneal strumosis: report of a case and histologic features. Endocr Pathol; 2010 Sep;21(3):199-203
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  • [Title] Predominant Brenner tumor combined with struma ovarii containing a papillary microcarcinoma associated with benign peritoneal strumosis: report of a case and histologic features.
  • Brenner tumor and struma ovarii, two uncommon ovarian tumors arising alone or together with dermoid cysts or adenomas, are both rare entities.
  • Few published reports describe coexisting Brenner tumor and malignant struma ovarii.
  • The mass consisted predominantly of a Brenner tumor associated with struma ovarii containing a single small island of thyroid tissue that had undergone malignant transformation into a well-differentiated papillary carcinoma and also normal thyroid tissue that had spread to the peritoneum.
  • The patient underwent radical surgical treatment and after 7 years follow-up is disease free.
  • [MeSH-major] Brenner Tumor / pathology. Carcinoma, Papillary / pathology. Neoplasms, Multiple Primary / pathology. Ovarian Neoplasms / pathology. Peritoneal Neoplasms / secondary. Struma Ovarii / secondary

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  • (PMID = 20532676.001).
  • [ISSN] 1559-0097
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Wong LY, Diamond TH: Severe ophthalmopathy developing after treatment of coexisting malignant struma ovarii and Graves' disease. Thyroid; 2009 Oct;19(10):1125-7
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  • [Title] Severe ophthalmopathy developing after treatment of coexisting malignant struma ovarii and Graves' disease.
  • [MeSH-major] Graves Ophthalmopathy / complications. Struma Ovarii / complications
  • [MeSH-minor] Adult. Anti-Inflammatory Agents / therapeutic use. Female. Graves Disease / pathology. Graves Disease / surgery. Humans. Hyperthyroidism / etiology. Hyperthyroidism / pathology. Magnetic Resonance Imaging. Postoperative Complications / pathology. Prednisone / therapeutic use. Thyroidectomy

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  • (PMID = 19772400.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; VB0R961HZT / Prednisone
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6. Morel O, Rohmer V, Girault S, Muratet JP, Berthelot C, Jallet P: Abnormal iodine-131 uptake in a benign mucinous ovarian cystadenoma mimicking struma ovarii. Clin Nucl Med; 2007 Jan;32(1):64-6
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  • [Title] Abnormal iodine-131 uptake in a benign mucinous ovarian cystadenoma mimicking struma ovarii.
  • [MeSH-major] Cystadenoma, Mucinous / diagnosis. Iodine Radioisotopes / pharmacokinetics. Ovarian Neoplasms / diagnosis. Struma Ovarii / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Thyroid Neoplasms / surgery. Thyroidectomy

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  • (PMID = 17179812.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
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7. Schmidt J, Derr V, Heinrich MC, Crum CP, Fletcher JA, Corless CL, Nosé V: BRAF in papillary thyroid carcinoma of ovary (struma ovarii). Am J Surg Pathol; 2007 Sep;31(9):1337-43
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  • [Title] BRAF in papillary thyroid carcinoma of ovary (struma ovarii).
  • BACKGROUND: Malignant struma ovarii (MSO) are rare tumors that arise from ectopic thyroid tissue in the ovary, benign struma ovarii (BSO).
  • Most MSO are histologically classified as papillary thyroid carcinomas (PTC).
  • Oncogenic activation of BRAF (35% to 69%), RAS (10%), or RET (5% to 30%) is common in PTC, and the mutations correlate with tumor subtype, patient age, and clinical behavior.
  • Corresponding benign tissues were evaluated when available.
  • [MeSH-major] Carcinoma, Papillary / genetics. Gene Expression Regulation, Neoplastic. Mutation. Ovarian Neoplasms / genetics. Proto-Oncogene Proteins B-raf / genetics. Struma Ovarii / genetics

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  • (PMID = 17721188.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / RET protein, human; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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8. Salvatori M, Dambra DP, D'Angelo G, Conte LL, Locantore P, Zannoni G, Campo V, Campo S: A case of metastatic struma ovarii treated with 131I therapy: focus on preservation of fertility and selected review of the literature. Gynecol Endocrinol; 2008 Jun;24(6):312-9
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  • [Title] A case of metastatic struma ovarii treated with 131I therapy: focus on preservation of fertility and selected review of the literature.
  • Struma ovarii is a rare monodermal ovarian teratoma composed predominantly of mature thyroid tissue.
  • We describe herein the case of a 22-year-old woman who underwent a right salpingo-oophorectomy for struma ovarii at the age of 12 years, who was admitted 8 years later with signs and symptoms of a left pelvic tumor.
  • Laparoscopy detected a left ovarian endometriotic cyst and multiple nodules on the pelvic peritoneum, right lateral abdominal wall, diaphragm, vesical plica and liver.
  • The diagnosis was abdominal and pelvic widespread dissemination of recurrent struma ovarii, with features consistent with the follicular variant of papillary thyroid carcinoma.
  • Because of the high degree of hormonogenesis shown by the metastases, the first administration was performed following use of recombinant human (rh) thyroid-stimulating hormone (TSH) to reach adequate TSH levels.
  • We also discuss the potential role and the possible benefit of using gonadotropin-releasing hormone analogs and ovarian tissue cryopreservation to preserve fertility in women treated with 131I for pelvic metastases from malignant struma ovarii.
  • [MeSH-major] Iodine Radioisotopes / therapeutic use. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Ovarian Neoplasms / radiotherapy. Ovarian Neoplasms / surgery. Struma Ovarii / radiotherapy. Struma Ovarii / surgery

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  • (PMID = 18584410.001).
  • [ISSN] 1473-0766
  • [Journal-full-title] Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • [ISO-abbreviation] Gynecol. Endocrinol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 9002-71-5 / Thyrotropin
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9. Piragua SC, Otis CN, Prefontaine M, Pantanowitz L: Cystic struma ovarii (with macrocystic change). Int J Surg Pathol; 2008 Oct;16(4):433-4
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  • [Title] Cystic struma ovarii (with macrocystic change).
  • In this article, a case of cystic struma ovarii with macrocystic change is presented.
  • Cysts derived from struma ovarii may mimic a mucinous or serous cystadenoma.
  • A careful examination for any thyroid microfollicles within fibrous septa or areas of solid stroma is key.
  • In problematic cases, immunohistochemical staining with thyroglobulin and thyroid transcription factor-1 may be required to establish the diagnosis.
  • [MeSH-major] Cysts / pathology. Ovarian Neoplasms / pathology. Struma Ovarii / pathology

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  • (PMID = 18397898.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / thyroid nuclear factor 1
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10. Choudhary S, Fasih N, Mc Innes M, Marginean C: Imaging of ovarian teratomas: appearances and complications. J Med Imaging Radiat Oncol; 2009 Oct;53(5):480-8
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  • [Title] Imaging of ovarian teratomas: appearances and complications.
  • Ovarian teratomas are the most common germ cell neoplasm.
  • The benign cystic teratoma shows typical imaging manifestations and can be complicated by torsion, rupture and uncommonly malignant degeneration.
  • Uncommon subtypes of teratomas include the immature, which is usually malignant at diagnosis.
  • The monodermal teratomas which include the struma ovarii may also have specific imaging characteristics that should be recognised on imaging.
  • This paper aims to provide a comprehensive review describing the spectrum of imaging findings of these ovarian tumours and associated complications.
  • [MeSH-major] Diagnostic Imaging / methods. Image Enhancement / methods. Ovarian Neoplasms / diagnosis. Teratoma / diagnosis

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  • (PMID = 19788483.001).
  • [ISSN] 1754-9485
  • [Journal-full-title] Journal of medical imaging and radiation oncology
  • [ISO-abbreviation] J Med Imaging Radiat Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 35
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11. Elisei R, Romei C, Castagna MG, Lisi S, Vivaldi A, Faviana P, Marinò M, Ceccarelli C, Pacini F, Pinchera A: RET/PTC3 rearrangement and thyroid differentiation gene analysis in a struma ovarii fortuitously revealed by elevated serum thyroglobulin concentration. Thyroid; 2005 Dec;15(12):1355-61
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  • [Title] RET/PTC3 rearrangement and thyroid differentiation gene analysis in a struma ovarii fortuitously revealed by elevated serum thyroglobulin concentration.
  • Struma ovarii (SO) is usually asymptomatic and only in a few cases it is associated with thyrotoxicosis.
  • The presurgical diagnosis is very uncommon.
  • Only the hystopathologic examination is able to reveal the characteristic features of SO, with thyroid cells organized in follicles as the main tumoral tissue constituent.
  • We report the case of a 59-year-old woman who came to our observation for the fortuitous finding of elevated serum thyroglobulin (Tg) levels (600-800 ng/mL).
  • Because the thyroid function was normal and the ultrasound showed only a subcentrimetric nodule, the clinical suspicious of a SO was considered.
  • Ultrasound examination of the abdomen showed a solid mass of 2 cm in the left ovary.
  • Three months after the resection of the left ovary serum Tg levels were markedly reduced (106 ng/mL), and its values continued to decrease down to 34 ng/mL at last control.
  • The histology showed that the ovarian mass was mainly constituted of thyroid tissue (98%), with no malignant features.
  • The molecular analysis of several thyroid differentiation gene mRNAs in the SO tissue showed an abundant expression of all genes but pendrin (PDS).
  • Despite the absence of malignant features, the expression of RET/PTC3 rearrangement was found, raising the possibility of a potential malignant nature of the tumor.
  • A cancer-free period of 3-4 years, as in our patient, is not long enough to definitively exclude a late onset metastatic disease but, unfortunately, the patient died of nonmedical reasons.
  • A quite exhaustive molecular analysis of thyroid specific genes and oncogenes provided two interesting findings: the low PDS mRNA expression, which may explain the low hormonal production and the absence of thyrotoxicosis and the presence of a RET/PTC3 rearrangement, which prompts the possibility of a late malignant evolution.
  • [MeSH-major] Gene Rearrangement. Oncogene Proteins, Fusion / genetics. Ovarian Neoplasms / genetics. Protein-Tyrosine Kinases / genetics. Struma Ovarii / genetics. Thyroglobulin / blood. Thyroid Gland / pathology

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  • (PMID = 16405408.001).
  • [ISSN] 1050-7256
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Transport Proteins; 0 / Oncogene Proteins, Fusion; 0 / RNA, Messenger; 0 / SLC26A4 protein, human; 9010-34-8 / Thyroglobulin; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / ret-PTC fusion oncoproteins, human
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12. Teale E, Gouldesbrough DR, Peacey SR: Graves' disease and coexisting struma ovarii: struma expression of thyrotropin receptors and the presence of thyrotropin receptor stimulating antibodies. Thyroid; 2006 Aug;16(8):791-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Graves' disease and coexisting struma ovarii: struma expression of thyrotropin receptors and the presence of thyrotropin receptor stimulating antibodies.
  • Struma ovarii is a rare cause of hyperthyroidism and particularly rare in patients with coexisting Graves' disease.
  • We describe a 28-year-old female who presented with symptoms and signs of hyperthyroidism (free thyroxine [FT(4)] 39 pmol/L, thyrotropin [TSH] < 0.05 mU/L) and associated ophthalmopathy, consistent with Graves' disease.
  • Radioisotope scanning showed focal uptake bilaterally in the neck and believing this was the source of thyroid hormone excess, carbimazole was restarted.
  • A left ovarian mass was found on ultrasound during the investigation of unrelated nephrotic syndrome resulting from focal segmental glomerulosclerosis.
  • A 555-g struma ovarii was removed surgically.
  • Circulating TSH receptor stimulating antibodies were positive and immunohistochemical studies confirm the presence of TSH receptors on the struma ovarii.
  • The demonstration of TSH receptors on the struma ovarii increases previous speculation that struma ovarii growth and function may be augmented by the circulating TSH receptor stimulating antibodies of Graves' disease.
  • [MeSH-major] Graves Disease / complications. Graves Disease / diagnosis. Hyperthyroidism / therapy. Receptors, Thyrotropin / immunology. Receptors, Thyrotropin / metabolism. Struma Ovarii / complications. Struma Ovarii / diagnosis
  • [MeSH-minor] Adult. Antibodies / chemistry. Carbimazole / pharmacology. Female. Glomerulosclerosis, Focal Segmental / diagnosis. Humans. Hypothyroidism / etiology. Immunoassay. Nephrotic Syndrome / complications. Radioisotopes. Thyrotropin / metabolism

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  • (PMID = 16910883.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Radioisotopes; 0 / Receptors, Thyrotropin; 8KQ660G60G / Carbimazole; 9002-71-5 / Thyrotropin
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13. Sokalska A, Timmerman D, Testa AC, Van Holsbeke C, Lissoni AA, Leone FP, Jurkovic D, Valentin L: Diagnostic accuracy of transvaginal ultrasound examination for assigning a specific diagnosis to adnexal masses. Ultrasound Obstet Gynecol; 2009 Oct;34(4):462-70
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  • [Title] Diagnostic accuracy of transvaginal ultrasound examination for assigning a specific diagnosis to adnexal masses.
  • OBJECTIVES: To determine the sensitivity and specificity of subjective evaluation of gray-scale and Doppler ultrasound findings (here called pattern recognition) when used by experienced ultrasound examiners with regard to making a specific diagnosis of adnexal masses.
  • METHODS: Within the framework of a European multicenter study, the International Ovarian Tumor Analysis study, comprising nine ultrasound centers, women with at least one adnexal mass were examined with gray-scale and color Doppler ultrasonography by experienced ultrasound examiners.
  • Using pattern recognition the examiners classified each mass as benign or malignant and suggested a specific diagnosis (e.g. dermoid cyst or endometrioma).
  • RESULTS: A total of 1066 women were included, of whom 800 had a benign mass and 266 a malignant mass.
  • A specific diagnosis based on ultrasound findings was suggested in 899 (84%) tumors.
  • The sensitivity was highest for benign teratoma/dermoid cysts (86%, 100/116), hydrosalpinges (86%, 18/21), peritoneal pseudocysts (80%, 4/5) and endometriomas (77%, 153/199), and lowest for functional cysts (17%, 4/24), paraovarian/parasalpingeal cysts (14%, 3/21), benign rare tumors (11%, 1/9), adenofibromas (8%, 3/39), simple cysts (6%, 1/18) and struma ovarii (0%, 0/5).
  • Dermoid cysts, hydrosalpinges, functional cysts, paraovarian cysts, peritoneal pseudocysts, fibromas/fibrothecomas and simple cysts were never misdiagnosed as malignancies by the ultrasound examiner, whereas more than 10% of inflammatory processes, adenofibromas and rare benign tumors including struma ovarii were misdiagnosed as malignancies.
  • CONCLUSIONS: Using subjective evaluation of gray-scale and Doppler ultrasound findings it is possible to make an almost conclusive diagnosis of a dermoid cyst, endometrioma and hydrosalpinx.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Middle Aged. Ovarian Neoplasms / classification. Ovarian Neoplasms / ultrasonography. Predictive Value of Tests. Prognosis. Risk Factors. Sensitivity and Specificity. Ultrasonography, Doppler

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  • (PMID = 19685552.001).
  • [ISSN] 1469-0705
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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14. Lanzafame S, Caltabiano R, Puzzo L, Immè A: Expression of thyroid transcription factor 1 (TTF-1) in extra thyroidal sites: papillary thyroid carcinoma of branchial cleft cysts and thyroglossal duct cysts and struma ovarii. Pathologica; 2006 Dec;98(6):640-4
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  • [Title] Expression of thyroid transcription factor 1 (TTF-1) in extra thyroidal sites: papillary thyroid carcinoma of branchial cleft cysts and thyroglossal duct cysts and struma ovarii.
  • The thyroid-associated transcription factor-1 (TTF-1) is a nuclear tissue specific protein, found only in thyroid and thyroid tumors regardless of histologic type as well as in lung carcinomas.
  • Most ectopic thyroid tissue are found along the thyroglossal duct tract and around the bilateral main lobes of thyroid glands.
  • Ectopic thyroid tissue within a branchial cleft cyst is a rare abnormality and papillary carcinoma arising in this tissue is extremely rare.
  • Thyroid tissue may also be found as one of the many components of teratoma, particularly those located in the ovary.
  • The aim of this study is to evaluate, through immunohistochemistry, the expression of TTF-1 in branchial cleft cysts with ectopic normal thyroid tissue, in primary thyroid papillary carcinomas of branchial cleft cysts and thyroglossal duct cysts and in struma ovarii, in order to evaluate the expression of this antigen in extra thyroidal sites.
  • [MeSH-major] Branchioma / metabolism. Carcinoma, Papillary / metabolism. Head and Neck Neoplasms / metabolism. Nuclear Proteins / biosynthesis. Ovarian Neoplasms / metabolism. Struma Ovarii / metabolism. Thyroglossal Cyst / metabolism. Thyroid Neoplasms / metabolism. Transcription Factors / biosynthesis

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  • (PMID = 17285841.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / thyroid nuclear factor 1
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15. Dhingra KK, Jain P, Garg A, Khurana N: Coexistent struma ovarii and serous cystadenofibroma in the same ovary. Int J Gynecol Pathol; 2009 May;28(3):231-3
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  • [Title] Coexistent struma ovarii and serous cystadenofibroma in the same ovary.
  • Struma ovarii is a highly specialized and rare form of mature teratomas constituting 2% of all teratomas although small foci of thyroid tissue may be found in 5% to 15% of teratomas.
  • Coexistence of this unusual germ cell tumor with ovarian epithelial tumors has been reported rarely; however, concomitant struma ovarii and serous cystadenofibroma has been mentioned in only 1 case report in the extensively searched medical literature.
  • We report a rare occurrence of struma ovarii along with a serous cystadenofibroma in a 47-year-old woman.
  • [MeSH-major] Adenofibroma / pathology. Neoplasms, Multiple Primary / pathology. Ovarian Neoplasms / pathology. Struma Ovarii / pathology

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  • [CommentIn] Int J Gynecol Pathol. 2012 Mar;31(2):149-50 [22317871.001]
  • (PMID = 19620940.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Wirtz ED, Bothwell N, Klem C: Role of the otolaryngologist in the treatment of struma ovarii. Laryngoscope; 2010 Feb;120(2):259-60
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  • [Title] Role of the otolaryngologist in the treatment of struma ovarii.
  • Struma ovarii, a rare germ cell tumor of the ovary composed of >50% thyroid tissue, is traditionally managed by gynecologic surgeons.
  • Although struma ovarii is typically cured by simple excision, otolaryngology-head and neck surgeons may play a critical role in caring for these patients.
  • In this article, we present two cases of struma ovarii and discuss the role of the otolaryngologist.
  • [MeSH-major] Neoplasms, Multiple Primary / diagnosis. Ovarian Neoplasms / diagnosis. Struma Ovarii / diagnosis
  • [MeSH-minor] Adult. Female. Humans. Middle Aged. Otolaryngology. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / pathology. Thyroid Neoplasms / surgery

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  • (PMID = 20013844.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Flavin R, Smyth P, Crotty P, Finn S, Cahill S, Denning K, Jinghuan Li, O'Regan E, O'Leary J, Sheils O: BRAF T1799A mutation occurring in a case of malignant struma ovarii. Int J Surg Pathol; 2007 Apr;15(2):116-20
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  • [Title] BRAF T1799A mutation occurring in a case of malignant struma ovarii.
  • Struma ovarii is an extremely rare tumor that occasionally undergoes malignant transformation.
  • Because struma ovarii is composed of thyroid tissue, it is conceivable that the pathogenetic events involved in thyroid follicular transformation may take place also in struma ovarii.
  • The authors describe a case of a classical variant of papillary thyroid carcinoma arising in a struma ovarii of a 22-year-old female.
  • The tumor was heterozygous for BRAF T1799A mutation.
  • This finding would suggest that malignant struma ovarii is similar histologically and genetically to primary papillary thyroid carcinoma.
  • [MeSH-major] Carcinoma, Papillary, Follicular / genetics. Mutation. Ovarian Neoplasms / genetics. Proto-Oncogene Proteins B-raf / genetics. Struma Ovarii / genetics. Thyroid Neoplasms / genetics

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  • (PMID = 17478764.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / RNA, Neoplasm; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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18. Makni SK, Bahri I, Ellouze S, Mnif H, Ayadi L, Ghariani M, Khmiri H, Boudawara T: [Malignant struma ovarii: a case report]. J Gynecol Obstet Biol Reprod (Paris); 2005 Dec;34(8):815-8
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  • [Title] [Malignant struma ovarii: a case report].
  • [Transliterated title] Goitre ovarien malin: une observation.
  • Malignant transformation of struma ovarii is exceptional (less than 1%).
  • The histolological diagnosis of malignancy is difficult especially in the well differentiated forms.
  • We report a case of malignant struma ovarii with metastasis observed in a 65-year-old woman who died rapidly from her disease.
  • [MeSH-major] Ovarian Neoplasms / diagnosis. Struma Ovarii / diagnosis

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  • (PMID = 16319775.001).
  • [ISSN] 0368-2315
  • [Journal-full-title] Journal de gynécologie, obstétrique et biologie de la reproduction
  • [ISO-abbreviation] J Gynecol Obstet Biol Reprod (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / KRT7 protein, human; 0 / Keratin-7; 68238-35-7 / Keratins; 9010-34-8 / Thyroglobulin
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19. Robboy SJ, Shaco-Levy R, Peng RY, Snyder MJ, Donahue J, Bentley RC, Bean S, Krigman HR, Roth LM, Young RH: Malignant struma ovarii: an analysis of 88 cases, including 27 with extraovarian spread. Int J Gynecol Pathol; 2009 Sep;28(5):405-22
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  • [Title] Malignant struma ovarii: an analysis of 88 cases, including 27 with extraovarian spread.
  • Struma ovarii that display extraovarian spread or later recurrence is exceedingly rare.
  • Among 88 patients with "malignant" struma ovarii followed for prolonged periods, several features helped to predict the adverse clinical course.
  • Adhesions (graded 2 to 4+), peritoneal fluid (> or =1 L) or ovarian serosal rent were worrisome features, occurring in 74% of 27 biologically malignant tumors but only 10% of 61 clinically benign tumors.
  • The size of the strumal component rather than the overall size of the ovarian teratoma also had some predictive value.
  • Except for a papillary pattern or poorly differentiated cancer, no microscopic feature reliably predicted the clinical outcome, including those typically associated with malignancy in primary thyroid tumors.
  • Eight tumors confined initially to the ovary (stage 1) recurred.
  • [MeSH-major] Ovarian Neoplasms / pathology. Struma Ovarii / pathology

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  • (PMID = 19696610.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Deshpande V, Oliva E, Young RH: Solid pseudopapillary neoplasm of the ovary: a report of 3 primary ovarian tumors resembling those of the pancreas. Am J Surg Pathol; 2010 Oct;34(10):1514-20
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  • [Title] Solid pseudopapillary neoplasm of the ovary: a report of 3 primary ovarian tumors resembling those of the pancreas.
  • We report 3 cases of a hitherto undescribed ovarian tumor histologically and immunohistochemically identical to pancreatic solid pseudopapillary neoplasms.
  • Two tumors involved the left ovary and 1 the right ovary.
  • They ranged from 3 to 25.5 cm and were confined to the ovary.
  • The tumor cells were monotonous and the nuclei were round to oval with pale chromatin and occasional longitudinal nuclear grooves.
  • One patient has been followed for 6 years and is free of disease.
  • The tumors likely to enter into the differential diagnosis include sex-cord stromal tumors, steroid cell tumors, and struma ovarii.
  • The morphologic and immunohistochemical similarity to pancreatic solid pseudopapillary neoplasm facilitates the accurate diagnosis of this rare ovarian neoplasm.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Ovarian Neoplasms / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adolescent. Biomarkers, Tumor / metabolism. Cadherins / metabolism. Cell Nucleus / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged. Treatment Outcome. Young Adult. beta Catenin / metabolism

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  • (PMID = 20871224.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins; 0 / beta Catenin
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21. Manini C, Magistris A, Puopolo M, Montironi PL: Cystic struma ovarii: a report of three cases. Pathologica; 2010 Feb;102(1):36-8
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  • [Title] Cystic struma ovarii: a report of three cases.
  • Three cases of cystic struma ovarii in women aged 16, 20 and 40 are described.
  • All patients had an asymptomatic ovarian mass at ultrasound scan.
  • The tumours, all of which were unilateral and confined to the ovary, ranged from 7 to 10 cm in the greatest dimension.
  • In the wall of the cysts, there was a small number of thyroid follicles.
  • The paucity of thyroid follicles and the non-specific appearance of the epithelial cells required a careful sampling and immunohistochemical staining for thyroglobulin to establish an exact diagnosis.
  • The postoperative period was uneventful and thyroid function remained normal.
  • In conclusion, cystic struma is probably often underdiagnosed and should be considered when evaluating cystic ovarian tumours whose features are not obviously those of another tumour type.
  • A careful search for thyroid follicles should be undertaken.
  • [MeSH-major] Ovarian Cysts / pathology. Ovarian Neoplasms / pathology. Struma Ovarii / pathology
  • [MeSH-minor] Female. Humans. Thyroid Gland / pathology

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  • (PMID = 20731253.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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22. Silva EG, Young RH: Endometrioid neoplasms with clear cells: a report of 21 cases in which the alteration is not of typical secretory type. Am J Surg Pathol; 2007 Aug;31(8):1203-8
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  • The presence of clear cells in genital tract neoplasms often reflexly prompts the diagnosis of a clear cell tumor but clear cells may be seen in many other neoplasms.
  • One tumor formed a cystic mass in the pelvis, 1 tumor involved the right fallopian tube, 1 the endometrium, and 18 the ovary.
  • One tumor was a cystadenofibroma, 1 a borderline tumor, and 19 were adenocarcinomas.
  • The distinction from clear cell carcinoma depends on awareness of this unusual variant of endometrioid neoplasia and a lack of the distinctive patterns of clear cell carcinoma; at this time, special studies, including immunohistochemistry, do not aid significantly although certainly negative reactions, such as for thyroglobulin protein (arguing against clear cell struma ovarii) may play a role in some differential diagnostic considerations.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Carcinoma, Endometrioid / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Disease-Free Survival. Female. Follow-Up Studies. Humans. Immunohistochemistry. Middle Aged. Neoplasm Staging

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  • [ErratumIn] Am J Surg Pathol. 2007 Oct;31(10):1628
  • (PMID = 17667544.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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23. Yoo SC, Chang KH, Lyu MO, Chang SJ, Ryu HS, Kim HS: Clinical characteristics of struma ovarii. J Gynecol Oncol; 2008 Jun;19(2):135-8
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  • [Title] Clinical characteristics of struma ovarii.
  • OBJECTIVE: To evaluate the clinical characteristics of struma ovarii.
  • METHODS: Twenty-five cases of struma ovarii were reviewed retrospectively from June 1994 to April 2007.
  • Although one patient had an abnormal thyroid function test, the laboratory findings normalized after operative treatment.
  • Diagnosis by preoperative imaging studies were 8 dermoid cysts, while only 3 cases were diagnosed as struma ovarii.
  • There were 4 cases of malignant struma ovarii, and no patients with recurrent disease.
  • CONCLUSION: Struma ovarii is a rare tumor.
  • The diagnosis was confirmed by pathologic findings.
  • The treatment of benign struma ovarii is surgical resection only.
  • The cases of malignant struma ovarii may need adjuvant treatment, but recurrence is uncommon.

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  • (PMID = 19471561.001).
  • [ISSN] 2005-0380
  • [Journal-full-title] Journal of gynecologic oncology
  • [ISO-abbreviation] J Gynecol Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2676458
  • [Keywords] NOTNLM ; Dermoid tumor / Malignancy / Struma ovarii
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24. Van Holsbeke C, Van Belle V, Leone FP, Guerriero S, Paladini D, Melis GB, Greggi S, Fischerova D, De Jonge E, Neven P, Bourne T, Valentin L, Van Huffel S, Timmerman D: Prospective external validation of the 'ovarian crescent sign' as a single ultrasound parameter to distinguish between benign and malignant adnexal pathology. Ultrasound Obstet Gynecol; 2010 Jul;36(1):81-7
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  • [Title] Prospective external validation of the 'ovarian crescent sign' as a single ultrasound parameter to distinguish between benign and malignant adnexal pathology.
  • OBJECTIVE: To determine the sensitivity and specificity of the 'ovarian crescent sign' (OCS)-a rim of normal ovarian tissue seen adjacent to an ipsilateral adnexal mass-as a sonographic feature to discriminate between benign and malignant adnexal masses.
  • METHODS: The patients included were a subgroup of patients participating in the International Ovarian Tumor Analysis (IOTA) Phase 2 study, which is an international multicenter study.
  • The gold standard was the histological diagnosis of the adnexal mass.
  • The ability of the OCS to discriminate between borderline or invasively malignant vs. benign adnexal masses, as well as between invasively malignant vs. other (benign and borderline) tumors, was determined and compared with the performance of subjective evaluation of ultrasound findings by the ultrasound examiner.
  • RESULTS: The OCS was evaluated in 1377 adnexal masses from 12 centers, 938 (68%) masses being benign, 86 (6%) borderline, 305 (22%) primary invasive and 48 (3%) metastases.
  • The OCS was present in 398 (42%) of 938 benign masses, in 14 (16%) of 86 borderline tumors, in 18 (6%) of 305 primary invasive tumors (one malignant struma ovarii, one uterine clear cell adenocarcinoma and 16 epithelial carcinomas, i.e. four Stage I and 12 Stage II-IV) and in two (4%) of 48 ovarian metastases.
  • For discrimination between invasive vs. benign or borderline tumors, the sensitivity for absent OCS was 94%, the specificity was 40%, the LR+ was 1.58 and the LR- was 0.14.
  • However it is a poor discriminator between benign and malignant adnexal masses.
  • [MeSH-major] Ovarian Neoplasms / ultrasonography. Ovary / ultrasonography
  • [MeSH-minor] Adnexal Diseases / ultrasonography. Diagnosis, Differential. Female. Humans. Neoplasm Staging. Predictive Value of Tests. Prospective Studies. Sensitivity and Specificity. Ultrasonography, Doppler

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  • [Copyright] Copyright 2010 ISUOG. Published by John Wiley & Sons, Ltd.
  • (PMID = 20217895.001).
  • [ISSN] 1469-0705
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] England
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25. Cherng SC, Wang YF, Fan YM, Chen CY, Yuan YN, Cheng CY: Malignant struma ovarii with peritoneal implants and pelvic structures and liver metastases demonstrated by I-131 SPECT and low-dose CT. Clin Nucl Med; 2005 Dec;30(12):797-8
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  • [Title] Malignant struma ovarii with peritoneal implants and pelvic structures and liver metastases demonstrated by I-131 SPECT and low-dose CT.
  • [MeSH-major] Iodine Radioisotopes. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Ovarian Neoplasms / diagnosis. Struma Ovarii / diagnosis. Tomography, Emission-Computed, Single-Photon / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 16319636.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 0 / Radiopharmaceuticals
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26. Park SB, Kim JK, Kim KR, Cho KS: Imaging findings of complications and unusual manifestations of ovarian teratomas. Radiographics; 2008 Jul-Aug;28(4):969-83
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  • [Title] Imaging findings of complications and unusual manifestations of ovarian teratomas.
  • Ovarian teratomas can be associated with various complications and demonstrate a wide spectrum of clinical and imaging features.
  • The complications include torsion (16% of ovarian teratomas), rupture (1%-4%), malignant transformation (1%-2%), infection (1%), and autoimmune hemolytic anemia (<1%).
  • These complications require different therapeutic strategies; therefore, timely and accurate diagnosis of these complications is important for optimal patient treatment.
  • In cases of complicated ovarian teratomas, the clinical manifestations provide only limited information and often overlap with those of other diseases.
  • Furthermore, ovarian teratomas may have unusual clinical and imaging manifestations, thereby leading to misdiagnosis.
  • These unusual manifestations include immature teratomas, monodermal teratomas (struma ovarii), combination tumors and collision tumors containing teratomas, and mature cystic teratomas without demonstrable fat or with pure fatty components.
  • To provide adequate treatment and prevent misdiagnosis, it is necessary to be familiar with the imaging findings of both the complications and the unusual manifestations of ovarian teratomas.
  • [MeSH-major] Diagnostic Imaging / methods. Ovarian Neoplasms / complications. Ovarian Neoplasms / diagnosis. Teratoma / complications. Teratoma / diagnosis

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  • (PMID = 18635624.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 53
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27. Chiofalo MG, Misso C, Insabato L, Lastoria S, Pezzullo L: Hyperthyroidism due to coexistence of Graves' disease and Struma ovarii. Endocr Pract; 2007 May-Jun;13(3):274-6
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  • [Title] Hyperthyroidism due to coexistence of Graves' disease and Struma ovarii.
  • OBJECTIVE: To report an unusual case of persistent thyrotoxicosis after treatment of Graves' disease, because of coexistence of struma ovarii.
  • METHODS: We report the clinical history, imaging studies, laboratory and pathologic data, and treatment in a patient with persistent hyperthyroidism after surgical treatment of Graves' disease.
  • In addition, we discuss some aspects of the pathogenesis of hyperthyroidism due to functioning struma ovarii.
  • RESULTS: A 42-year-old woman underwent near-total thyroidectomy for treatment of Graves' disease.
  • Pelvic ultrasonography revealed a mass (11 by 8 by 7.1 cm) arising from the right ovary, with both solid and cystic components.
  • Abdominal surgical exploration was performed, and the final histologic diagnosis was struma ovarii.
  • The symptoms of hyperthyroidism diminished, and 3 weeks postoperatively, the thyroid hormone levels were in the hypothyroid range.
  • CONCLUSION: In patients with refractory hyperthyroidism after thyroid surgical treatment, radioiodine scanning should be performed to diagnose or exclude the functioning profile of ovarian masses.
  • [MeSH-major] Graves Disease / complications. Ovarian Neoplasms / complications. Struma Ovarii / complications. Thyrotoxicosis / etiology

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  • (PMID = 17599859.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Ezon I, Zilbert N, Pinkney L, Wei JJ, Malik R, Nadler EP: A large struma ovarii tumor removed via laparoscopy in a 16-year-old adolescent. J Pediatr Surg; 2007 Aug;42(8):E19-22
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  • [Title] A large struma ovarii tumor removed via laparoscopy in a 16-year-old adolescent.
  • Struma ovarii is rare ovarian tumor that is characterized by the presence of at least 50% thyroid tissue on histologic examination.
  • This usually benign neoplasm is predominantly found in women between the ages of 40 and 60 years and infrequently in the pediatric age group.
  • In the foregoing report, we present an unusual case of a large struma ovarii in a 16-year-old adolescent girl with abdominal pain and increasing abdominal girth.
  • We conclude that the diagnosis of struma ovarii should be considered in adolescent girls presenting with large cystic ovarian masses and that a laparoscopic approach to management is the treatment of choice.
  • [MeSH-major] Laparoscopy. Ovarian Neoplasms / surgery. Ovariectomy / methods. Struma Ovarii / surgery

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  • (PMID = 17706482.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Costa MA, Póvoa AM, Pires MC, Paiva VL, Pinto C, Martínez-de-Oliveira J: Struma ovarii: a rare form of presentation and clinical review. Acta Obstet Gynecol Scand; 2005 Aug;84(8):819-20
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  • [Title] Struma ovarii: a rare form of presentation and clinical review.
  • [MeSH-major] Ovarian Neoplasms / pathology. Ovarian Neoplasms / surgery. Struma Ovarii / pathology. Struma Ovarii / surgery

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  • (PMID = 16026413.001).
  • [ISSN] 0001-6349
  • [Journal-full-title] Acta obstetricia et gynecologica Scandinavica
  • [ISO-abbreviation] Acta Obstet Gynecol Scand
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 5
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30. Rana V, Srinivas V, Bandyopadhyay S, Ghosh SK, Singh Y: Bilateral benign non functional struma ovarii with Pseudo-Meigs' syndrome. Indian J Pathol Microbiol; 2009 Jan-Mar;52(1):94-6
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  • [Title] Bilateral benign non functional struma ovarii with Pseudo-Meigs' syndrome.
  • Bilateral presentation of benign Struma ovarii is rare and has not been reported frequently in published literature.
  • These findings were suspicious for an ovarian malignancy.
  • After surgery the diagnosis of non functional, bilateral benign Struma ovarii was made.
  • Struma ovarii is a specialized ovarian teratoma composed predominantly of mature thyroid tissue.
  • The combination of struma ovarii and elevated CA-125 levels has been reported infrequently.
  • This is a rare case of bilateral benign struma ovarii associated with Pseudo-Meigs' syndrome and elevated CA-125 levels.
  • Surgical excision of the ovarian masses induced immediate resolution of the ascites and pleural effusion and a reduction of the serum CA-125 level.
  • [MeSH-major] Meigs Syndrome / pathology. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / pathology. Struma Ovarii / complications. Struma Ovarii / diagnosis

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  • (PMID = 19136795.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / CA-125 Antigen
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31. Gkountouvas A, Nikas M, Chatjimarkou F, Thomas D, Georgiadis P, Kaldrimidis P: Thyroid cancer in Greece. A tertiary center experience. J BUON; 2010 Oct-Dec;15(4):674-8
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  • [Title] Thyroid cancer in Greece. A tertiary center experience.
  • PURPOSE: to present the frequency and distribution of histological subtypes of primary thyroid carcinoma cases diagnosed at our Department.
  • METHODS: we retrospectively analyzed the records of all patients with primary thyroid carcinoma admitted to our Department from January 01, 2002 until December 31, 2008.
  • RESULTS: of 1,607 patients with primary thyroid carcinoma 1510 (94%) suffered from differentiated thyroid carcinoma (DTC), 71 (4%) from medullary thyroid carcinoma (MTC), 10 (< 1%) from anaplastic thyroid carcinoma (ATC), 9 (<1%) from primary thyroid non Hodgkin's lymphoma, 1 (< 1%) from primary thyroid Hodgkin's lymphoma, 1 (< 1%) from squamous cell carcinoma of the thyroid, and 6 patients (< 1%) suffered from carcinoma of ectopic thyroid tissue (1 malignant struma ovarii, 2 carcinoma in thyroglossal duct remnants, and 3 patients presented with thyroid tissue carcinoma in cervical lymph nodes).
  • CONCLUSION: differentiated thyroid carcinoma is by far the most common primary malignancy of the thyroid gland.
  • Papillary thyroid carcinomas constitute the vast majority of these neoplasms.
  • Larger studies are necessary to better understand and evaluate the clinical characteristics, behavior and prevalence of thyroid cancer in our country.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Carcinoma / pathology. Carcinoma, Medullary / pathology. Carcinoma, Squamous Cell / pathology. Hodgkin Disease / pathology. Lymphoma, Non-Hodgkin / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 21229628.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] Thyroid cancer, papillary
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32. Yassa L, Sadow P, Marqusee E: Malignant struma ovarii. Nat Clin Pract Endocrinol Metab; 2008 Aug;4(8):469-72
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  • [Title] Malignant struma ovarii.
  • Pelvic ultrasonography showed a 9 cm left ovarian mass.
  • The ovarian mass proved to be a struma ovarii with numerous microscopic foci of papillary thyroid carcinoma.
  • The patient had no symptoms of hyperthyroidism, and her thyroid function and serum thyroglobulin levels were normal.
  • INVESTIGATIONS: Investigations included a pelvic ultrasound scan, histological examination of the ovarian mass and omental nodules, and lymph node sampling.
  • DIAGNOSIS: Malignant struma ovarii.
  • In addition, the patient underwent thyroid ultrasonography, which showed a 1 cm nodule that proved benign on biopsy.
  • Follow-up pelvic ultrasonography 1 year later showed no evidence of recurrent disease, and her serum thyroglobulin levels remained normal.
  • [MeSH-major] Ovarian Neoplasms / diagnosis. Struma Ovarii / diagnosis
  • [MeSH-minor] Adult. Female. Humans. Thyroglobulin / blood. Thyroid Gland / drug effects. Thyroid Gland / physiopathology. Thyroid Gland / ultrasonography. Thyrotropin / blood. Thyroxine / therapeutic use

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  • (PMID = 18560398.001).
  • [ISSN] 1745-8374
  • [Journal-full-title] Nature clinical practice. Endocrinology & metabolism
  • [ISO-abbreviation] Nat Clin Pract Endocrinol Metab
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / T32 DK007529
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 9002-71-5 / Thyrotropin; 9010-34-8 / Thyroglobulin; Q51BO43MG4 / Thyroxine
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33. McCluggage WG, Young RH: Immunohistochemistry as a diagnostic aid in the evaluation of ovarian tumors. Semin Diagn Pathol; 2005 Feb;22(1):3-32
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  • [Title] Immunohistochemistry as a diagnostic aid in the evaluation of ovarian tumors.
  • Aspects of immunohistochemistry (IHC), which are useful in the diagnosis of ovarian tumors (mostly neoplasms but also a few tumor-like lesions), are discussed.
  • One of the most common situations in which IHC may aid is in the evaluation of tumors with follicles or other patterns which bring a sex cord-stromal tumor into the differential.
  • The distinction between a sex cord tumor and an endometrioid carcinoma with sex-cord-like patterns may be greatly aided by the triad of epithelial membrane antigen (EMA), inhibin, and calretinin, the latter two being typically positive and EMA negative in sex cord tumors, the converse being typical of endometrioid carcinoma.
  • The well-known staining of the latter neoplasm for S-100 protein and HMB-45 may be very helpful in evaluating melanomas with follicular or other unusual patterns, a challenging aspect of ovarian tumor interpretation.
  • The most common monodermal teratoma, struma ovarii, usually has an overt follicular pattern and is easily recognized, but recognition of unusual appearances ranging from oxyphilic to clear cell to various patterns of malignant struma may be greatly aided by a thyroglobulin or TTF 1 stain.
  • IHC for neuroendocrine markers may assist in the diagnosis of primary and metastatic carcinoid tumor.
  • The broad differential diagnosis of glandular neoplasms with an endometrioid-pseudoendometrioid morphology, or mucinous cell type, has been the subject of much exploration in recent years, particularly the distinction between primary and metastatic neoplasms.
  • The rare differential of metastatic cervical adenocarcinoma versus primary ovarian mucinous or endometrioid carcinoma may be aided by strong p16 staining of the former.
  • Staining for alpha-fetoprotein may aid in confirming the diagnosis of endometrioid-like (and hepatoid) variants of yolk sac tumor.
  • Ependymoma of the ovary may also have an endometrioid-like glandular pattern, but positive stains for glial fibrillary acidic protein contrast with the negative results in others neoplasms with a similar pattern.
  • Immunostains may be very helpful in the evaluation of oxyphilic tumors and tumor-like lesions and in some unusual forms of clear cell neoplasia, such as clear cell struma, both subjects being reviewed herein.
  • As in tumor pathology in general, various markers may be crucial in the diagnosis of small round cell tumors of the ovary, and familiar markers of epithelial, lymphoid, leukemic, and melanocytic neoplasms may assist in the analysis of high grade tumors with a poorly differentiated carcinoma, lymphoma-granulocytic sarcoma, malignant melanoma differential.
  • The evaluation of ovarian cystic lesions may be aided by thyroglobulin or TTF 1 (cystic struma), glial fibrillary acid protein (ependymal cysts), and inhibin-calretinin (follicle cysts and unilocular granulosa cell tumors).
  • [MeSH-major] Immunohistochemistry. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Neoplasm Metastasis. Ovarian Cysts / diagnosis. Ovarian Follicle / pathology

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  • (PMID = 16512597.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 115
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34. Boutross-Tadross O, Saleh R, Asa SL: Follicular variant papillary thyroid carcinoma arising in struma ovarii. Endocr Pathol; 2007;18(3):182-6
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  • [Title] Follicular variant papillary thyroid carcinoma arising in struma ovarii.
  • Struma ovarii is a rare monodermal ovarian teratoma in which thyroid tissue is the predominant or exclusive element.
  • Malignant transformation is known to occur, usually as classical papillary thyroid carcinoma (PTC).
  • However, the recognition of follicular variant PTC raises the possibility of similar malignancy arising in struma ovarii.
  • We examined 13 cases of struma ovarii to determine if these lesions can exhibit histological, immunohistochemical, and/or molecular features of follicular variant PTC.
  • The three cases considered to be benign based on histologic and cytologic criteria were negative for CK19 and HBME-1 by immunohistochemistry, and had no evidence of BRAF mutation or ret/PTC-1 and ret/PTC-3 rearrangements.
  • These results indicate that follicular variant PTC can occur in struma ovarii and that such lesions exhibit the same morphologic and immunohistochemical profile as follicular variant PTC in thyroid.
  • The application of molecular testing to verify the diagnosis can be valuable, as these lesions may harbor ret/PTC gene rearrangements.
  • [MeSH-major] Carcinoma, Papillary / pathology. Carcinoma, Papillary, Follicular / secondary. Ovarian Neoplasms / secondary. Struma Ovarii. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. Cohort Studies. DNA Mutational Analysis. Female. Humans. Keratin-19 / metabolism. Middle Aged. Proto-Oncogene Proteins B-raf / genetics. Proto-Oncogene Proteins c-ret / genetics. Retrospective Studies

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  • (PMID = 18058267.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / HBME-1 antigen; 0 / Keratin-19; EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / RET protein, human; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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35. Ostör G, Tóth I, Hrubyné Tóth Z, Bazsa S: [Cystic struma ovarii, a rare form of ovarian tumor--case report, and review of the literature]. Orv Hetil; 2007 Dec 2;148(48):2285-7
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  • [Title] [Cystic struma ovarii, a rare form of ovarian tumor--case report, and review of the literature].
  • [Transliterated title] Cysticus struma ovarii, egy ritka ováriumtumor - esetismertetés és irodalmi áttekintés.
  • Struma ovarii represents less than 3% of ovarian teratomas.
  • It can be associated with thyroid biology abnormalities, and in exceptionally rare cases it can be malignant.
  • The authors report a case of a 31-year-old woman who underwent resection of a left ovarian cyst, presenting with the clinical features of an ovarian cancer (large pelvic mass, ascites and elevated CA-125 serum levels).
  • The pathologic diagnosis was benign struma ovarii.
  • The postoperative thyroid function remained normal.
  • [MeSH-major] Ovarian Neoplasms / diagnosis. Struma Ovarii / diagnosis

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  • (PMID = 18039620.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / CA-125 Antigen; 9002-71-5 / Thyrotropin
  • [Number-of-references] 13
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36. Marcy PY, Thariat J, Benisvy D, Azuar P: Lethal, malignant, metastatic struma ovarii. Thyroid; 2010 Sep;20(9):1037-40
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  • [Title] Lethal, malignant, metastatic struma ovarii.
  • BACKGROUND: Struma ovarii (SO) is extremely rare, with less than 200 reported cases in the medical literature.
  • SO is defined by the presence of an ovarian tumor containing thyroid tissue as the predominant cell type.
  • We report on a patient presenting with left ovarian cystic SO and lethal outcome.
  • Imaging scan analysis showed pelvic tumor recurrence and hypervascular liver metastases during follow-up as well as peritoneal carcinomatosis in the pelvis, right abdominal wall, and malignant ascites.
  • The patient died from cachexia at 37 months after diagnosis.
  • CONCLUSIONS: Such an aggressive malignant disease and lethal course of SO is rare.
  • Total thyroidectomy is mandatory to exclude a primary thyroid neoplasm and for radioiodine therapy and follow-up.
  • SO may spread to contralateral ovary, pelvic nodes, peritoneum, liver, lungs, and bones through hematogeneous spread, which is different from the dissemination pattern of papillary thyroid carcinomas.
  • Imaging highlights the mixed behavior of this ovarian tumor.
  • [MeSH-major] Carcinoid Tumor / diagnosis. Ovarian Neoplasms / diagnosis. Struma Ovarii / diagnosis

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  • (PMID = 20825300.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 9010-34-8 / Thyroglobulin
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37. Cao D, Guo S, Allan RW, Molberg KH, Peng Y: SALL4 is a novel sensitive and specific marker of ovarian primitive germ cell tumors and is particularly useful in distinguishing yolk sac tumor from clear cell carcinoma. Am J Surg Pathol; 2009 Jun;33(6):894-904
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] SALL4 is a novel sensitive and specific marker of ovarian primitive germ cell tumors and is particularly useful in distinguishing yolk sac tumor from clear cell carcinoma.
  • Ovarian primitive germ cell tumors (GCTs) are uncommon tumors and sometimes pose diagnostic challenges.
  • Among them, yolk sac tumor (YST) poses the greatest diagnostic difficulty and can be mistaken for clear cell carcinoma (CCC).
  • Here by immunohistochemistry, we investigated a novel marker SALL4 in 98 GCTs (29 YSTs, 18 dysgerminomas, 6 gonadoblastomas, 6 embryonal carcinomas, 15 immature and 12 mature teratomas, 7 carcinoid tumors, 3 strumal carcinoids, and 2 struma ovarii) with particular interest of exploring SALL4 to distinguish YST from CCC.
  • We found that SALL4 is strongly positive in more than 90% tumor cells in all YSTs, dysgerminomas, gonadoblastomas, and embryonal carcinomas.
  • Except 3 CCCs with focal SALL4 staining (<15% tumor cells), SALL4 is negative in the remaining 160 non-GCTs.
  • Three (10%) and 4 (14%) YSTs show focal (<2% tumor cells) CK7 and EMA staining, respectively.
  • CK7 and EMA are positive in all 45 CCCs but 3 (7%) and 1 (2%) cases show staining in less than 30% tumor cells, respectively.
  • Our findings indicate that SALL4 is a novel sensitive and specific marker for ovarian primitive GCTs.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Endodermal Sinus Tumor / diagnosis. Ovarian Neoplasms / diagnosis. Transcription Factors / biosynthesis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Neoplasms, Germ Cell and Embryonal / diagnosis. Neoplasms, Germ Cell and Embryonal / metabolism. Sensitivity and Specificity


38. Usta IM, Khoury NG, Khalil AM, Nassar AH: Coexistence of a round ligament dermoid cyst and struma ovarii in pregnancy. Eur J Obstet Gynecol Reprod Biol; 2006 Jun 1;126(2):271-2
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  • [Title] Coexistence of a round ligament dermoid cyst and struma ovarii in pregnancy.
  • [MeSH-major] Dermoid Cyst / diagnosis. Neoplasms, Multiple Primary / diagnosis. Ovarian Neoplasms / diagnosis. Pregnancy Complications, Neoplastic / diagnosis. Round Ligament of Uterus. Struma Ovarii / diagnosis
  • [MeSH-minor] Adult. Cesarean Section. Diagnosis, Differential. Female. Humans. Infant, Newborn. Pregnancy. Pregnancy Trimester, Third. Prenatal Diagnosis

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  • (PMID = 16412553.001).
  • [ISSN] 0301-2115
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Ireland
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39. Celestino R, Magalhães J, Castro P, Triller M, Vinagre J, Soares P, Sobrinho-Simões M: A follicular variant of papillary thyroid carcinoma in struma ovarii. Case report with unique molecular alterations. Histopathology; 2009 Oct;55(4):482-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A follicular variant of papillary thyroid carcinoma in struma ovarii. Case report with unique molecular alterations.
  • [MeSH-major] Carcinoma, Papillary / pathology. Ovarian Neoplasms / pathology. Teratoma / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Genes, ras / genetics. Humans. Mutation / genetics. Proto-Oncogene Proteins B-raf / genetics

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  • (PMID = 19817905.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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40. Balci TA, Kabasakal L: Is the I-131 whole-body scanning proper for follow-up management of the patients with malignant struma ovarii without performing the thyroidectomy? Gynecol Oncol; 2005 Nov;99(2):520
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Is the I-131 whole-body scanning proper for follow-up management of the patients with malignant struma ovarii without performing the thyroidectomy?
  • [MeSH-major] Iodine Radioisotopes. Ovarian Neoplasms / radionuclide imaging. Struma Ovarii / radionuclide imaging. Thyroid Gland / surgery

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  • [CommentOn] Gynecol Oncol. 2004 Sep;94(3):835-9 [15350384.001]
  • (PMID = 15963556.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
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41. Obeidat BR, Amarin ZO: Struma ovarii with pseudo-Meigs' syndrome and elevated CA125 levels. J Obstet Gynaecol; 2007 Jan;27(1):97-8
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  • [Title] Struma ovarii with pseudo-Meigs' syndrome and elevated CA125 levels.
  • [MeSH-major] CA-125 Antigen / blood. Meigs Syndrome / complications. Ovarian Neoplasms / blood. Ovarian Neoplasms / complications. Struma Ovarii / blood. Struma Ovarii / complications

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  • (PMID = 17365481.001).
  • [ISSN] 0144-3615
  • [Journal-full-title] Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
  • [ISO-abbreviation] J Obstet Gynaecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CA-125 Antigen
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42. Morrissey K, Winkel C, Hild S, Premkumar A, Stratton P: Struma ovarii coincident with Hashimoto's thyroiditis: an unusual cause of hyperthyroidism. Fertil Steril; 2007 Aug;88(2):497.e15-7
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  • [Title] Struma ovarii coincident with Hashimoto's thyroiditis: an unusual cause of hyperthyroidism.
  • OBJECTIVE: To report the identification of struma ovarii in a patient with a history of struma ovarii and new hyperthyroidism.
  • PATIENT(S): A woman with hyperthyroidism who has struma ovarii coincident with Hashimoto's thyroiditis.
  • MAIN OUTCOME MEASURE(S): Measurement of thyroid hormone parameters before and after surgery.
  • RESULT(S): After removal of the second struma ovarii, hyperthyroidism resolved.
  • CONCLUSION(S): In a patient with two different causes of abnormal thyroid function, it is important to seek an encompassing clinical scenario.
  • [MeSH-major] Hashimoto Disease / complications. Hyperthyroidism / complications. Ovarian Neoplasms / complications. Struma Ovarii / complications

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  • [Cites] Clin Imaging. 2000 Jan-Feb;24(1):28-33 [11120414.001]
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  • (PMID = 17276434.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 HD008728-07
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS28567; NLM/ PMC2753978
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43. Roth LM, Karseladze AI: Highly differentiated follicular carcinoma arising from struma ovarii: a report of 3 cases, a review of the literature, and a reassessment of so-called peritoneal strumosis. Int J Gynecol Pathol; 2008 Apr;27(2):213-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Highly differentiated follicular carcinoma arising from struma ovarii: a report of 3 cases, a review of the literature, and a reassessment of so-called peritoneal strumosis.
  • Struma ovarii has elicited considerable interest because of its many unique features since Ludwig Pick first elucidated its relationship to teratoma in the early part of the 20th century.
  • The most common thyroid-type malignancies to arise in struma ovarii are papillary and follicular carcinomas.
  • In this article, we describe a newly recognized neoplasm originating from struma ovarii that we interpret as follicular carcinoma with a high degree of differentiation.
  • By definition, all of these cases have an innocuous appearance resembling that of nonneoplastic thyroid tissue in both the ovary and sites of dissemination.
  • The peritoneal involvement more often was diagnosed at the same time as the ovarian struma; however, the systemic dissemination occurred subsequent to oophorectomy.
  • Our index patient with highly differentiated follicular carcinoma (HDFCO) developed peritoneal dissemination and para-aortic lymph node metastases 26 years after excision of ovarian struma.
  • Vascular invasion was not identified in any of the cases; however, the primary neoplasm extended to the surface of the ovary in 2 cases with peritoneal involvement.
  • Because of its harmless histological appearance, this form of follicular carcinoma characteristically cannot be diagnosed until the neoplasm spreads beyond the ovary, thus, showing evidence of aggressive behavior.
  • The corollary of this observation is that cases having the histological appearance of ordinary struma ovarii can rarely behave in a malignant fashion.
  • Although cases of typical thyroid-type carcinoma with extraovarian dissemination are relatively easy to diagnose, those with an innocuous histological appearance present nosological and diagnostic difficulties.
  • The differential diagnosis of peritoneal dissemination of struma includes HDFCO, the typical types of thyroid cancer, and so-called strumosis.
  • The treatment of choice for patients with HDFCO is local resection of the extraovarian tumor with subsequent thyroidectomy followed by radioactive iodine ablation.
  • [MeSH-major] Carcinoma, Papillary, Follicular / pathology. Ovarian Neoplasms / pathology. Struma Ovarii / pathology
  • [MeSH-minor] Adult. Cell Differentiation. Disease Progression. Female. Humans. Middle Aged. Neoplasm Invasiveness. Peritoneum / pathology

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  • (PMID = 18317221.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 39
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44. Loizzi V, Cormio G, Resta L, Fattizzi N, Vicino M, Selvaggi L: Pseudo-Meigs syndrome and elevated CA125 associated with struma ovarii. Gynecol Oncol; 2005 Apr;97(1):282-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pseudo-Meigs syndrome and elevated CA125 associated with struma ovarii.
  • BACKGROUND: Struma ovarii is a rare form of ovarian neoplasm composed entirely and predominantly of thyroid tissue.
  • The association of pseudo-Meigs syndrome, elevation of CA125 and hyperthyroidism to struma ovarii is a rare condition.
  • CASE: We report an unusual presentation of a postmenopausal woman with benign struma ovarii associated with pseudo-Meigs syndrome, hypertiroidism, and elevated CA125 serum level, and a large complex right pelvic mass thereby mimicking an ovarian cancer.
  • CONCLUSIONS: Struma ovarii is a rare cause of ascites, hydrothorax, elevated CA125, and hyperthyroidism.
  • This rare condition should be considered in the differential diagnosis in patients with ascites and pleural effusions but with negative cytology.
  • [MeSH-major] CA-125 Antigen / blood. Carcinoid Tumor / blood. Meigs Syndrome / blood. Ovarian Neoplasms / blood. Struma Ovarii / blood
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Hyperthyroidism / blood

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  • (PMID = 15790478.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CA-125 Antigen
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45. Tomee JF, van der Heijden PF, van den Hout JH, Brinkhuis M, Veneman TF: Papillary carcinoma in struma ovarii: an unusual presentation. Neth J Med; 2008 Jun;66(6):248-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary carcinoma in struma ovarii: an unusual presentation.
  • Struma ovarii is the presence of thyroid tissue as the major cellular component in an ovarian tumour.
  • Papillary carcinoma in struma ovarii is exceptionally rare.
  • We report a case of papillary carcinoma in struma ovarii in a postmenopausal 51-year-old female who initially presented clinically with hyperthyroidism.
  • An abdominal mass was located by radiography and pathological investigation revealed a papillary carcinoma in struma ovarii.
  • [MeSH-major] Carcinoma, Papillary / diagnosis. Ovarian Neoplasms / diagnosis. Struma Ovarii
  • [MeSH-minor] Diagnosis, Differential. Endosonography. Female. Follow-Up Studies. Humans. Middle Aged. Ovariectomy / methods. Tomography, X-Ray Computed

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  • (PMID = 18689908.001).
  • [ISSN] 0300-2977
  • [Journal-full-title] The Netherlands journal of medicine
  • [ISO-abbreviation] Neth J Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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46. Daneshbod Y, Atefi S, Daneshbod K, Ganjei-Azar P: Cytologic findings in struma ovarii. Diagn Cytopathol; 2007 Sep;35(9):612-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytologic findings in struma ovarii.
  • [MeSH-major] Ovarian Neoplasms / pathology. Struma Ovarii / pathology

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  • (PMID = 17703442.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 9010-34-8 / Thyroglobulin
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47. Roth LM, Talerman A, Wadsley J, Karseladze AI: Risk factors in thyroid-type carcinoma arising in ovarian struma: a report of 15 cases with comparison to ordinary struma ovarii. Histopathology; 2010 Jul;57(1):148-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Risk factors in thyroid-type carcinoma arising in ovarian struma: a report of 15 cases with comparison to ordinary struma ovarii.
  • [MeSH-major] Ovarian Neoplasms / pathology. Struma Ovarii / pathology

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  • (PMID = 20653787.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Letter
  • [Publication-country] England
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48. Zekri JM, Manifold IH, Wadsley JC: Metastatic struma ovarii: late presentation, unusual features and multiple radioactive iodine treatments. Clin Oncol (R Coll Radiol); 2006 Dec;18(10):768-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic struma ovarii: late presentation, unusual features and multiple radioactive iodine treatments.
  • Metastatic malignant struma ovarii is rare and there is a lack of agreement on the criteria of diagnosis and the lines of management.
  • Here we describe a patient with struma ovarii that was initially diagnosed as benign and presented 10 years later with distant metastases.
  • The case was associated with a number of unusual features and challenging management issues, such as a delayed diagnosis of recurrence, functioning metastases with treatment consequences, tumour lysis-induced thyrotoxicosis and cerebrospinal fluid rhinorrhea.
  • The diagnosis and management of struma ovarii should be led by an expert multidisciplinary team.
  • Radioactive iodine should be considered in the management of metastatic disease.
  • [MeSH-major] Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / radiotherapy. Struma Ovarii / diagnosis. Struma Ovarii / radiotherapy
  • [MeSH-minor] Adult. Brain Neoplasms / pathology. Brain Neoplasms / secondary. Diagnosis, Differential. Female. Humans. Iodine Radioisotopes / therapeutic use. Neoplasm Metastasis. Ovarian Follicle / pathology. Thyroglobulin / metabolism. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / secondary. Treatment Outcome

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  • (PMID = 17168212.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 9010-34-8 / Thyroglobulin
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49. Niculescu S, Crauciuc E, Gargu G, Niculescu D, Filip V, Ene D, Vasilescu A: [Struma ovarii]. Rev Med Chir Soc Med Nat Iasi; 2008 Apr-Jun;112(2):406-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Struma ovarii].
  • [Transliterated title] Struma ovarii.
  • Struma ovarii is a rare tumor in its pure form, but its true incidence is hard to estimate because of all the variation in the diagnostic criteria due to the fact that some authors reported it as within a teratoma and others only in its pure form.
  • In general, it is an asymptomatic tumor, "benign-like" in most of the cases, and the diagnostic is based only on the histopathological findings.
  • MATERIAL AND METHOD: This is a retrospective study of all ovarian tumors treated in our departments over a period of 11 years, from January 1, 1995 to January 1, 2006.
  • 879 tumors were removed: 88.39% benign and 11.61% malignant.
  • Struma ovarii was demonstrated in 2 patients.
  • The clinical examination and ultrasound suggested ovarian tumors, but the diagnosis was made on the histopathological findings.
  • [MeSH-major] Ovarian Neoplasms. Struma Ovarii

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  • (PMID = 19295011.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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50. Kim D, Cho HC, Park JW, Lee WA, Kim YM, Chung PS, Park SG, Ahn WS, Han SJ, Park CH: Struma ovarii and peritoneal strumosis with thyrotoxicosis. Thyroid; 2009 Mar;19(3):305-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Struma ovarii and peritoneal strumosis with thyrotoxicosis.
  • BACKGROUND: Struma ovarii is a highly specialized form of mature ovarian teratoma consisting of thyroid tissue and exhibiting all the histological features of the thyroid gland.
  • Malignant transformation of thyroid tissue in struma ovarii and metastasis are extremely uncommon.
  • In rare cases, benign thyroid tissue may spread to the peritoneal cavity, and pathologic examination of the peritoneal implants shows multiple nodules of varying sizes of mature thyroid tissue similar to struma ovarii.
  • SUMMARY: We report a 49-year-old woman with struma ovarii complicated by peritoneal strumosis with thyrotoxicosis.
  • After surgical resection of the struma ovarii and peritoneal strumosis the patient became euthyroid.
  • The relative contribution to circulating thyroid hormones by the patient's struma ovarii as compared to the peritoneal strumosis is not known.
  • [MeSH-major] Ovarian Neoplasms / complications. Peritoneal Cavity / pathology. Struma Ovarii / complications. Thyrotoxicosis / complications
  • [MeSH-minor] Female. Humans. Middle Aged. Ovary / pathology. Whole Body Imaging

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  • (PMID = 19265502.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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51. Zhang X, Axiotis C: Thyroid-type carcinoma of struma ovarii. Arch Pathol Lab Med; 2010 May;134(5):786-91
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  • [Title] Thyroid-type carcinoma of struma ovarii.
  • Struma ovarii is a monodermal variant of ovarian teratoma.
  • Thyroid-type carcinoma arising in struma ovarii is rare.
  • The most common type is papillary carcinoma, followed by typical follicular carcinoma, and the new entity of follicular carcinoma-highly differentiated follicular carcinoma of ovarian origin; other forms occur rarely.
  • Consensus on the surgical and postoperative treatment of patients with thyroid-type carcinoma arising in struma ovarii has not been reached.
  • Thyroid-type carcinomas arising in struma ovarii, especially the newly recognized entity-highly differentiated follicular carcinoma of ovarian origin-have a favorable prognosis.
  • [MeSH-major] Carcinoid Tumor / pathology. Ovarian Neoplasms / pathology. Struma Ovarii / pathology
  • [MeSH-minor] Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Diagnosis, Differential. Female. Humans

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  • (PMID = 20441513.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 29
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52. García A, Castellví J, López M, Gil A, de la Torre J, Ramón y Cajal S: Malignant struma ovarii mimic clear cell carcinoma. Arch Gynecol Obstet; 2005 Mar;271(3):251-5
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  • [Title] Malignant struma ovarii mimic clear cell carcinoma.
  • INTRODUCTION: Struma ovarii are quite unusual lesions that represent less than 3% of all teratomas and its malignant transformation is very uncommon.
  • The clinical manifestations are characteristic of pelvic tumor and the hormonal metabolism is not usually modified.
  • Radiography, employing ultrasound procedures, is the most commonly used pre-surgical detection method but only histological examination makes the diagnosis.
  • CASE REPORT: We show a case of a 22-year-old patient with an ovarian tumor that was discovered by ultrasound examination and surgically removed.
  • The histologic study revealed struma ovarii with malignant transformation towards follicular carcinoma and unlike previously published cases, had a prevalence of clear cells.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Ovarian Neoplasms / pathology. Struma Ovarii / pathology
  • [MeSH-minor] Adult. Antigens, CD57. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Neprilysin. Ovariectomy. Reverse Transcriptase Polymerase Chain Reaction. Thyroglobulin / blood

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  • (PMID = 14986024.001).
  • [ISSN] 0932-0067
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD57; 9010-34-8 / Thyroglobulin; EC 3.4.24.11 / Neprilysin
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53. Lao M, Koike J, Chauhan S, Schiano M, Plata M: Struma Ovarii with a focus of follicular variant of papillary thyroid cancer: a case report. W V Med J; 2008 Jul-Aug;104(4):12-4
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  • [Title] Struma Ovarii with a focus of follicular variant of papillary thyroid cancer: a case report.
  • BACKGROUND: Struma Ovarii is a mature ovarian teratoma that consists mainly of thyroid tissue.
  • Mature cystic teratomas may contain small amounts of thyroid tissue.
  • Carcinomatous change in Struma Ovarii is extremely rare.
  • No guidelines exist regarding the staging and treatment of malignant Struma Ovarii.
  • OBJECTIVES: To report a case of Struma Ovarii with a focus follicular variant papillary thyroid cancer.
  • Struma Ovarii with a focus of follicular variant of papillary thyroid cancer was diagnosed during the subsequent laparoscopy and ovarian cystectomy.
  • FOLLOW-UP: Tumor markers, thyroid studies, thyroid scan, and whole body scans were normal.
  • CONCLUSION: Optimal treatment and surveillance of malignant struma ovarii has yet to be determined.
  • [MeSH-major] Carcinoid Tumor / parasitology. Carcinoid Tumor / surgery. Ovarian Neoplasms / pathology. Ovarian Neoplasms / surgery. Struma Ovarii / pathology. Struma Ovarii / surgery


54. Kunstmann L, Fénichel P: [Struma ovarii, a rare form of ovarian tumor]. Gynecol Obstet Fertil; 2007 Jan;35(1):49-54
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  • [Title] [Struma ovarii, a rare form of ovarian tumor].
  • [Transliterated title] Goitre ovarien: une forme particulière de tératome de l'ovaire.
  • Struma ovarii, a rare form of ovarian tumor, represents less than 3% of ovarian teratomas.
  • Diagnosis is usually a surprise of pelvic ultrasound or histological analysis.
  • Struma ovarii can be associated with thyroid biology abnormalities, or exceptionally become malignant, and thus managed as a thyroid cancer.
  • [MeSH-major] Ovarian Neoplasms / diagnosis. Struma Ovarii / diagnosis
  • [MeSH-minor] Age Factors. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged. Prognosis

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  • (PMID = 17196426.001).
  • [ISSN] 1297-9589
  • [Journal-full-title] Gynécologie, obstétrique & fertilité
  • [ISO-abbreviation] Gynecol Obstet Fertil
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 33
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55. Roth LM, Miller AW 3rd, Talerman A: Typical thyroid-type carcinoma arising in struma ovarii: a report of 4 cases and review of the literature. Int J Gynecol Pathol; 2008 Oct;27(4):496-506
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  • [Title] Typical thyroid-type carcinoma arising in struma ovarii: a report of 4 cases and review of the literature.
  • Struma ovarii has elicited considerable interest because of its many unique features since Ludwig Pick first elucidated its relationship to teratoma in the early part of the 20th century.
  • In this article, we report 3 cases of papillary and 1 of follicular thyroid carcinoma; 2 of these cases were associated with mature cystic teratoma.
  • In regard to the occurrence of thyroid-type carcinoma in struma ovarii, precise terminology should be used, and the expression malignant struma ovarii was avoided as a diagnostic term.
  • Upon review of the literature, papillary carcinoma and follicular carcinoma are the most frequent types of malignancy to occur in ovarian struma; other forms of thyroid carcinoma occur only rarely.
  • The diagnostic criteria for cases of papillary carcinoma are similar to those described in the cervical thyroid gland and are based primarily on nuclear and architectural features.
  • In reference to follicular carcinoma, invasion into the surrounding ovarian tissue, vascular invasion, or metastasis is evidence of malignancy.
  • Histological malignancy in a struma does not necessarily equate with biological malignancy, and the majority of thyroid-type carcinomas do not spread beyond the ovary.
  • Occasionally, metastases of ovarian struma have an innocuous histological appearance, and such cases are referred to as highly differentiated follicular carcinoma of ovarian origin (HDFCO).
  • Because its histological appearance resembles that of nonneoplastic thyroid, HDFCO characteristically cannot be diagnosed until the neoplasm spreads beyond the ovary.
  • In this article, we apply the term typical thyroid carcinoma to those forms of thyroid malignancy arising in ovarian struma that closely resemble the types described in the cervical thyroid gland to distinguish them from HDFCO.
  • Typical follicular carcinoma is more aggressive than the somewhat more common papillary carcinoma, and HDFCO is the least aggressive of these tumor types.
  • Cases of thyroid-type carcinoma arising in the ovary sometimes lack evidence of preexisting struma.
  • The more aggressive thyroid-type neoplasms can arise in thyroid tissue within a mature cystic teratoma, or they may overgrow and replace the struma.
  • Primary thyroid-type carcinoma must be distinguished from rare instances of ovarian metastases that originate in the cervical thyroid gland and the less differentiated forms from other ovarian neoplasms such as clear cell adenocarcinoma and tumors with an oxyphilic appearance.
  • In the differential diagnosis with other ovarian neoplasms, cases of thyroid-type carcinoma associated with strumal carcinoid should not be diagnosed as malignant strumal carcinoid because the latter diagnosis might lead to suboptimal therapy.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Carcinoid Tumor / pathology. Carcinoma, Papillary / pathology. Ovarian Neoplasms / pathology. Struma Ovarii / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 18753973.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Guven ES, Dilbaz S, Ilhan AK, Demir OF, Haberal A: Struma ovarii complicating pregnancy. J Obstet Gynaecol; 2005 Jul;25(5):512-3
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  • [Title] Struma ovarii complicating pregnancy.
  • [MeSH-major] Ovarian Neoplasms / diagnosis. Pregnancy Complications, Neoplastic / diagnosis. Struma Ovarii / diagnosis

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  • (PMID = 16183597.001).
  • [ISSN] 0144-3615
  • [Journal-full-title] Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
  • [ISO-abbreviation] J Obstet Gynaecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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57. Iavazzo C, Vorgias G, Psarrou A, Lekka I, Katsoulis M: Late struma ovarii diagnosis many years after total thyroidectomy. A rare entity. J BUON; 2008 Oct-Dec;13(4):573-4
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  • [Title] Late struma ovarii diagnosis many years after total thyroidectomy. A rare entity.
  • We present the case of a 53-year-old lady with incidental diagnosis of struma ovarii 10 years after total thyroidectomy due to papillary thyroid carcinoma.
  • The disease was diagnosed owing to high levels of serum thyroglobulin.
  • [MeSH-major] Ovarian Neoplasms / diagnosis. Struma Ovarii / diagnosis. Thyroid Neoplasms / surgery. Thyroidectomy

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  • (PMID = 19145683.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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58. Ruel IF, Fierrard H, Vercellino L, Bernard L, Hindie E, Duron F, Toubert ME: Pulmonary metastasis of struma ovarii: a case report. Clin Nucl Med; 2010 Sep;35(9):692-4
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  • [Title] Pulmonary metastasis of struma ovarii: a case report.
  • Surgical resection of 3 nodules revealed differentiated thyroid carcinoma.
  • Thyroid and neck ultrasound was normal.
  • A review of her history revealed that this patient underwent an ovarian cyst resection 15 years ago.
  • Reexamination of pathology samples, with the help of immunohistochemical markers, concluded to a struma ovarii.
  • Struma ovarii is a rare ovarian tumor mostly benign.
  • Metastasis of malignant struma ovarii are rare.
  • Treatment of the malignant struma ovarii implies ovarian surgical resection, total thyroidectomy, and I-131 therapy.
  • [MeSH-major] Lung Neoplasms / secondary. Ovarian Neoplasms / pathology. Struma Ovarii / pathology
  • [MeSH-minor] Adult. Female. Humans. Iodine Radioisotopes / therapeutic use. Positron-Emission Tomography. Thyroid Neoplasms / secondary. Whole-Body Irradiation

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  • (PMID = 20706043.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
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59. Amalaseelan JV, Perera KA: An unusual variant of malignant struma ovarii. Ceylon Med J; 2008 Jun;53(2):55-6
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  • [Title] An unusual variant of malignant struma ovarii.
  • Struma ovarii is a highly specialised form of mature ovarian teratoma.
  • When thyroid tissue constitutes 50% or more of the ovarian neoplasm, the tumour is termed struma ovarii.
  • Malignant struma ovarii is rare and makes up 0.1-0.3% of all ovarian teratomas [2].
  • We describe a case of follicular variant of papillary carcinoma arising from struma ovarii with elevated CA-125 and pseudo-Meig syndrome.
  • [MeSH-major] Ovarian Neoplasms / pathology. Struma Ovarii / pathology

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  • (PMID = 18678124.001).
  • [ISSN] 0009-0875
  • [Journal-full-title] The Ceylon medical journal
  • [ISO-abbreviation] Ceylon Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sri Lanka
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60. Mitrou S, Manek S, Kehoe S: Cystic struma ovarii presenting as pseudo-Meigs' syndrome with elevated CA125 levels. A case report and review of the literature. Int J Gynecol Cancer; 2008 Mar-Apr;18(2):372-5
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  • [Title] Cystic struma ovarii presenting as pseudo-Meigs' syndrome with elevated CA125 levels. A case report and review of the literature.
  • Struma ovarii is a rare ovarian teratoma consisted predominantly of mature thyroid tissue.
  • Although the vast majority of strumas are benign, they can present mimicking malignancy.
  • The patient underwent laparotomy, and histology revealed a benign struma ovarii.
  • Twelve months after the removal of the tumor, the patient remained disease free, with no clinical or radiologic evidence of effusion, and normal CA125 levels.
  • This is only the fifth case in the English literature of a benign struma ovarii presenting as pseudo-Meigs' syndrome with elevated CA125.
  • Struma ovarii should be included in the differential diagnosis of a pelvic mass that presents with ascites, hydrothorax, and elevated tumor markers.
  • [MeSH-major] Meigs Syndrome / diagnosis. Ovarian Neoplasms / diagnosis. Struma Ovarii / diagnosis
  • [MeSH-minor] CA-125 Antigen / blood. Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 18334015.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CA-125 Antigen
  • [Number-of-references] 19
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61. Prasad P, Nunns D, Ubhi CS, Chaudry Z, Soomro I: A rare case of follicular thyroid carcinoma in ovarian struma. Surgeon; 2008 Oct;6(5):313-5
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  • [Title] A rare case of follicular thyroid carcinoma in ovarian struma.
  • Struma ovarii is a form of specialised mature teratoma, with predominantly mature thyroid tissue in an ovarian teratoma as seen in 2% of cases.
  • This 40-year-old female patient had an incidental finding of a pelvic mass during investigation of secondary amenorrhoea.
  • The histopathology revealed a bilateral mature teratoma of the ovary with follicular thyroid carcinoma in the right ovarian struma (malignant struma).
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Ovarian Neoplasms / pathology. Struma Ovarii / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 18939380.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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62. Ng L, Brennan B: Struma ovarii in a patient with a history of papillary thyroid carcinoma. Pathology; 2006 Oct;38(5):461-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Struma ovarii in a patient with a history of papillary thyroid carcinoma.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Ovarian Neoplasms / pathology. Struma Ovarii / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Iodine Radioisotopes / therapeutic use. Neoplasms, Second Primary. Thyroid Gland / radiation effects

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  • (PMID = 17008292.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
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63. Novac L, Niculescu M, Simionescu C, Stanescu MR, Novac M: Bilateral struma ovarii: a case mimicking an ovarian neoplasm. Eur J Gynaecol Oncol; 2008;29(4):414-6
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  • [Title] Bilateral struma ovarii: a case mimicking an ovarian neoplasm.
  • We present a case of bilateral struma ovarii which developed postoperatively and was histopathologically diagnosed after the patient was hospitalized for investigation and treatment of tumoral anexal bilateral formations.
  • Data from the literature, together with histopathologic, diagnostic and therapeutic aspects of the disease were checked again taking into account the scarcity of this lesion, especially bilaterally.
  • [MeSH-major] Ovarian Neoplasms / diagnosis. Struma Ovarii / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Treatment Outcome

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  • (PMID = 18714585.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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64. Jung SI, Kim YJ, Lee MW, Jeon HJ, Choi JS, Moon MH: Struma ovarii: CT findings. Abdom Imaging; 2008 Nov-Dec;33(6):740-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Struma ovarii: CT findings.
  • BACKGROUND: The purpose of this study was to evaluate computed tomographic findings of struma ovarii.
  • METHODS: Computed tomography (CT) scans of 13 pathologically proven struma ovarii were retrospectively reviewed by two radiologists in consensus.
  • CONCLUSIONS: On CT scans, struma ovarii appeared most often as a smooth marginated multicystic mass with a high attenuation lesion on precontrast scans and no or moderate cyst wall enhancement.
  • [MeSH-major] Ovarian Neoplasms / radiography. Struma Ovarii / radiography. Tomography, Spiral Computed / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Contrast Media. Female. Humans. Iohexol / analogs & derivatives. Middle Aged. Observer Variation. Ovary / radiography. Radiographic Image Enhancement / methods. Retrospective Studies. Young Adult

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  • (PMID = 18214583.001).
  • [ISSN] 1432-0509
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 4419T9MX03 / Iohexol; 712BAC33MZ / iopromide
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65. Jiang W, Lu X, Zhu ZL, Liu XS, Xu CJ: Struma ovarii associated with pseudo-Meigs' syndrome and elevated serum CA 125: a case report and review of the literature. J Ovarian Res; 2010;3:18
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  • [Title] Struma ovarii associated with pseudo-Meigs' syndrome and elevated serum CA 125: a case report and review of the literature.
  • The association of pseudo-Meigs' syndrome, elevation of CA 125 to the struma ovarii is a rare condition.
  • Here we report a 46-year-old case of the struma ovarii, presented with ascites, hydrothorax, right ovarian mass and elevated serum CA 125 level.
  • These findings were misdiagnosed for an ovarian malignancy at the first impression.
  • Immediate resolution of the ascites, hydrothorax and normalization of the serum CA 125 level were followed by ovarian mass removal.
  • Struma ovarii could be a rare cause of ascites, hydrothorax, ovarian mass and elevated CA 125.
  • This rare condition should be considered in the differential diagnosis in patents with ascites and pleural effusions but with negative cytology.

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  • (PMID = 20670426.001).
  • [ISSN] 1757-2215
  • [Journal-full-title] Journal of ovarian research
  • [ISO-abbreviation] J Ovarian Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2923141
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66. Bolat F, Erkanli S, Kayaselcuk F, Aslan E, Tuncer I: Malignant struma ovarii: a case report. Pathol Res Pract; 2005;201(5):409-12
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  • [Title] Malignant struma ovarii: a case report.
  • Malignant struma ovarii is a rare form of the ovarian germ cell tumors.
  • Hence, diagnosis and management of malignant struma ovarii have not been clearly defined.
  • We present the case of a 34-year-old woman with papillary carcinoma arising in struma ovarii.
  • The malignant component of this tumor was detected after laparoscopic removal, and a re-staging operation was performed afterwards.
  • In this paper, clinical features, treatment guidelines, diagnostic features, and immunohistochemical characteristics of this tumor are reviewed.
  • [MeSH-major] Carcinoma, Papillary / pathology. Ovarian Neoplasms / pathology. Struma Ovarii / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Nuclear Proteins / analysis. Review Literature as Topic. Thyroglobulin / analysis. Transcription Factors / analysis

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  • (PMID = 16047952.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / thyroid nuclear factor 1; 9010-34-8 / Thyroglobulin
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67. Salman WD, Singh M, Twaij Z: A case of papillary thyroid carcinoma in struma ovarii and review of the literature. Patholog Res Int; 2010;2010:352476
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  • [Title] A case of papillary thyroid carcinoma in struma ovarii and review of the literature.
  • Malignancy in struma ovarii is a rare form of ovarian germ cell tumour.
  • Because of its rarity, the diagnosis and management of the tumour have not been clearly defined.
  • We present a case of 67- year-old female with papillary carcinoma arising in struma ovarii and review the literature on malignancy in struma ovarii cases, focusing on management of these cases.

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  • (PMID = 21151690.001).
  • [ISSN] 2042-003X
  • [Journal-full-title] Pathology research international
  • [ISO-abbreviation] Patholog Res Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2991076
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68. Bartel TB, Juweid ME, O'dorisio T, Sivitz W, Kirby P: Scintigraphic detection of benign struma ovarii in a hyperthyroid patient. J Clin Endocrinol Metab; 2005 Jun;90(6):3771-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Scintigraphic detection of benign struma ovarii in a hyperthyroid patient.
  • [MeSH-major] Hyperthyroidism / radionuclide imaging. Ovarian Neoplasms / radionuclide imaging. Struma Ovarii / radionuclide imaging
  • [MeSH-minor] Female. Graves Disease / radiotherapy. Graves Disease / surgery. Humans. Iodine Radioisotopes / therapeutic use. Middle Aged. Ovary / radiography. Thyroidectomy. Thyrotropin / blood. Treatment Outcome

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  • (PMID = 15917485.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 9002-71-5 / Thyrotropin
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69. Hatami M, Breining D, Owers RL, Del Priore G, Goldberg GL: Malignant struma ovarii--a case report and review of the literature. Gynecol Obstet Invest; 2008;65(2):104-7
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  • [Title] Malignant struma ovarii--a case report and review of the literature.
  • BACKGROUND: Struma ovarii is a rare monodermal ovarian teratoma composed predominantly of mature thyroid tissue.
  • CASE REPORT: A 53-year-old female presented with a 19 x 5 x 5 cm pelvic mass that was treated with bilateral salpingo-oophorectomy, pelvic and para-aortic lymph node sampling, omentectomy and appendectomy and staging for an ovarian tumor.
  • Re-evaluation of the patient after surgery revealed that she was clinically euthyroid and there was no thyroid malignancy.
  • Histopathology revealed papillary thyroid carcinoma arising in struma ovarii (malignant struma ovarii).
  • CONCLUSION: Malignant struma ovarii is a very rare malignant ovarian teratoma.
  • In young patients unilateral oophorectomy and complete surgical staging should be considered when the tumor is confined to the one ovary (stage Ia).
  • Long-term follow-up for the detection of metastases or tumor recurrence by serial serum thyroglobulin and (131)I scan or positron emission tomography/computed tomography may be required in selected patients with this rare tumor.
  • [MeSH-major] Carcinoma, Papillary / pathology. Ovarian Neoplasms / pathology. Struma Ovarii / pathology. Thyroid Neoplasms / pathology

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  • [Copyright] (c) 2007 S. Karger AG, Basel.
  • (PMID = 17890867.001).
  • [ISSN] 1423-002X
  • [Journal-full-title] Gynecologic and obstetric investigation
  • [ISO-abbreviation] Gynecol. Obstet. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 23
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70. Rim SY, Kim SM, Choi HS: Struma ovarii showing clinical characteristics of ovarian malignancy. Int J Gynecol Cancer; 2005 Nov-Dec;15(6):1156-9
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  • [Title] Struma ovarii showing clinical characteristics of ovarian malignancy.
  • Struma ovarii is a rare form of ovarian neoplasm, composed entirely or predominantly of thyroid tissue and generally a benign germ cell tumor of the ovary.
  • However, the combination of struma ovarii and elevated CA125 has rarely been reported.
  • We experienced a rare case of a postmenopausal woman with benign struma ovarii associated with massive ascites, a complex pelvic mass.
  • The clinical impression was ovarian malignancy.
  • Surgical excision of the ovarian mass induced immediate resolution of the ascites and a normalization of the serum CA125 level.
  • No recurrence of the ascites or of the tumor has been observed during the 10-month follow-up.
  • Struma ovarii can mimic ovarian malignancy clinically, particularly if complex and associated with ascites and an elevated CA125 level.
  • [MeSH-major] Biomarkers, Tumor / blood. CA-125 Antigen / blood. Ovarian Neoplasms / pathology. Struma Ovarii / pathology. Teratoma / pathology

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  • (PMID = 16343201.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-125 Antigen
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71. Garg K, Soslow RA, Rivera M, Tuttle MR, Ghossein RA: Histologically bland "extremely well differentiated" thyroid carcinomas arising in struma ovarii can recur and metastasize. Int J Gynecol Pathol; 2009 May;28(3):222-30
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  • [Title] Histologically bland "extremely well differentiated" thyroid carcinomas arising in struma ovarii can recur and metastasize.
  • Struma ovarii (SO) infrequently harbor carcinomas that are histologically similar to those arising in the eutopic thyroid.
  • Eight patients presented with pelvic-related symptoms whereas 2 were incidentally discovered during pregnancy, all with disease confined to the ovary.
  • There were 8 papillary thyroid carcinomas (PTCs) (2 classic and 6 follicular variant) and 2 poorly differentiated thyroid carcinomas.
  • Two of the 10 thyroid carcinomas relapsed after an initial diagnosis of "benign" struma.
  • Both occurred in young women with ovarian cysts discovered during pregnancy.
  • The cystectomy from 1 patient showed thyroid follicles with nuclear features of the follicular variant of PTC whereas the cyst from the second patient showed thyroid follicles with subtle nuclear features, suggestive but not diagnostic of PTC.
  • Both patients presented with disseminated PTC 3 and 4 years after the initial diagnosis, involving the pelvis in both cases and also the liver parenchyma in 1 case.
  • The 2 patients received radioactive iodine therapy after thyroidectomy and are both alive with disease 6 years after diagnosis.
  • The criteria separating hyperplastic nodules from well-differentiated follicular variant of PTC in the thyroid gland seem to be applicable to thyroid-type carcinomas arising in SO.
  • [MeSH-major] Neoplasm Recurrence, Local / pathology. Neoplasms, Multiple Primary / pathology. Ovarian Neoplasms / pathology. Pregnancy Complications, Neoplastic / pathology. Struma Ovarii / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 19620939.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Isotopes
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72. Ghander C, Lussato D, Conte Devolx B, Mundler O, Taïeb D: Incidental diagnosis of struma ovarii after thyroidectomy for thyroid cancer: functional imaging studies and follow-up. Gynecol Oncol; 2006 Aug;102(2):378-80
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  • [Title] Incidental diagnosis of struma ovarii after thyroidectomy for thyroid cancer: functional imaging studies and follow-up.
  • BACKGROUND: Struma ovarii is a rare ovarian germ-cell tumor containing thyroid tissue.
  • We report an unusual case of incidental diagnosis of struma ovarii after thyroidectomy for thyroid cancer.
  • CASE: A 24-year-old woman presented with a papillary thyroid carcinoma (pT3N1).
  • After (131)I administration for thyroid remnant ablation, whole-body scan showed a thyroid bed uptake and a right pelvic uptake corresponding to an ovarian cyst on ultrasonography.
  • Histopathological analysis revealed a benign struma ovarii.
  • CONCLUSION: Only few cases of incidental scintigraphic diagnosis of struma ovarii have been described.
  • To our knowledge, it is the first case revealed after remnant ablation for thyroid carcinoma.
  • The distinction with ovarian metastasis is discussed.
  • [MeSH-major] Ovarian Neoplasms / diagnosis. Pituitary Neoplasms / surgery. Struma Ovarii / diagnosis. Thyroid Neoplasms / surgery


73. Michels A, Haugen B: Malignant struma ovarii. J Clin Endocrinol Metab; 2010 Apr;95(4):1505
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant struma ovarii.
  • [MeSH-major] Carcinoma, Papillary, Follicular / radionuclide imaging. Ovarian Neoplasms / radionuclide imaging. Struma Ovarii / radionuclide imaging

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  • (PMID = 20375218.001).
  • [ISSN] 1945-7197
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 9010-34-8 / Thyroglobulin
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74. Saito N, Hatori T, Murata N, Shibuya K, Mitsuda A, Hasegawa C, Akima M, Ikawa M, Nonaka H: A case of concomitant occurrence of struma ovarii and malignant transformation of cystic teratoma. Int J Surg Pathol; 2007 Jul;15(3):318-20
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  • [Title] A case of concomitant occurrence of struma ovarii and malignant transformation of cystic teratoma.
  • A 77-year-old woman received a total abdominal hysterectomy and bilateral salpingo-oophorectomy because of a tumor in the left ovary.
  • The solid lesion was diagnosed as struma ovarii.
  • Immunohistochemically, the tumor cells were positive for cytokeratin7, and were negative for cytokeratin20 and thyroid transcription factor-1.
  • The authors diagnosed that struma ovarii and other parats coexisted as a poorly differentiated adenocarcinoma that had arisen from a mature ovarian cystic teratoma.
  • As for the identification of the origin of adenocarcinomas arising from mature ovarian cystic teratomas, more cases need to be identified and investigated.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Ovarian Neoplasms / pathology. Struma Ovarii / pathology. Teratoma / pathology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Aged. Female. Gene Expression Regulation, Neoplastic. Humans. Keratin-7 / genetics. Keratin-7 / metabolism. Maximum Tolerated Dose

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  • (PMID = 17652549.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-7
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75. Yang CW, Liang WY, Lin JK, Chiou TJ, Lee CH, Jiang JK: Colonic metastasis from a papillary thyroid carcinoma arising in struma ovarii. Int J Colorectal Dis; 2010 Jul;25(7):913-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Colonic metastasis from a papillary thyroid carcinoma arising in struma ovarii.
  • [MeSH-major] Carcinoma, Papillary / pathology. Colonic Neoplasms / secondary. Ovarian Neoplasms / pathology. Struma Ovarii / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 20012969.001).
  • [ISSN] 1432-1262
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Germany
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76. McDougall IR: Metastatic struma ovarii: the burden of truth. Clin Nucl Med; 2006 Jun;31(6):321-4
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  • [Title] Metastatic struma ovarii: the burden of truth.
  • A 58-year-old woman was found to have metastatic thyroid cancer in her liver.
  • She had no palpable thyroid nodule and had a normal ultrasound of the thyroid.
  • By a process of elimination, a diagnosis of metastatic struma ovarii was established.
  • Treatment of metastatic thyroid cancer from struma ovarii, including removal of the normal thyroid and administration of I-131, is presented.
  • [MeSH-major] Ovarian Neoplasms / radionuclide imaging. Struma Ovarii / radionuclide imaging. Struma Ovarii / secondary. Thyroid Neoplasms / secondary
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Iodine Radioisotopes / therapeutic use. Middle Aged. Radiopharmaceuticals. Thyroidectomy. Treatment Outcome

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  • (PMID = 16714888.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 0 / Radiopharmaceuticals
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77. Paladini D, Vassallo M, Sglavo G, Nappi C: Struma ovarii associated with hyperthyroidism, elevated CA 125 and pseudo-Meigs syndrome may mimic advanced ovarian cancer. Ultrasound Obstet Gynecol; 2008 Aug;32(2):237-8
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  • [Title] Struma ovarii associated with hyperthyroidism, elevated CA 125 and pseudo-Meigs syndrome may mimic advanced ovarian cancer.
  • [MeSH-major] Adnexal Diseases / ultrasonography. Ovarian Neoplasms / ultrasonography. Struma Ovarii / ultrasonography
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Hyperthyroidism / complications. Meigs Syndrome / diagnosis. Treatment Outcome

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  • (PMID = 18618418.001).
  • [ISSN] 1469-0705
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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78. Valentin L, Ameye L, Jurkovic D, Metzger U, Lécuru F, Van Huffel S, Timmerman D: Which extrauterine pelvic masses are difficult to correctly classify as benign or malignant on the basis of ultrasound findings and is there a way of making a correct diagnosis? Ultrasound Obstet Gynecol; 2006 Apr;27(4):438-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Which extrauterine pelvic masses are difficult to correctly classify as benign or malignant on the basis of ultrasound findings and is there a way of making a correct diagnosis?
  • OBJECTIVES: To determine which extrauterine pelvic masses are difficult to correctly classify as benign or malignant on the basis of ultrasound findings, and to determine if the use of logistic regression models for calculation of individual risk of malignancy would improve the diagnostic accuracy in difficult tumors.
  • On the basis of subjective evaluation of ultrasound findings, the examiner classified each mass as being certainly benign, probably benign, unclassifiable, probably malignant or certainly malignant.
  • Even when the examiner found the mass unclassifiable (i.e. difficult mass) he or she was obliged to state whether the mass was more likely to be benign or malignant.
  • Borderline malignant tumors (n = 55) proved to be most difficult to assess with only 47% being correctly classified (i.e. classified as malignant), 29% being incorrectly classified (i.e. classified as benign) and 24% being unclassifiable vs. 90% of non-borderline tumors being correctly classified, 3% being incorrectly classified and 8% being unclassifiable (P < 0.0001).
  • Papillary cystadeno(fibro)mas, myomas and cases of struma ovarii were also more common among the unclassifiable masses than among the classifiable ones (5.6% vs. 1.1%, P = 0.008; 4.4% vs. 0.9%, P = 0.02; 4.4% vs. 0.2%, P = 0.0006).
  • CONCLUSIONS: Borderline tumors cause great diagnostic difficulties, but so do papillary cystadeno(fibro)mas, struma ovarii and some myomas.
  • [MeSH-minor] Adnexa Uteri / ultrasonography. Adolescent. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Logistic Models. Middle Aged. Prospective Studies. ROC Curve. Sensitivity and Specificity. Ultrasonography, Doppler

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  • [Copyright] Copyright 2006 ISUOG.
  • (PMID = 16526098.001).
  • [ISSN] 0960-7692
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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79. Doganay M, Gungor T, Cavkaytar S, Sirvan L, Mollamahmutoglu L: Malignant struma ovarii with a focus of papillary thyroid cancer: a case report. Arch Gynecol Obstet; 2008 Apr;277(4):371-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant struma ovarii with a focus of papillary thyroid cancer: a case report.
  • Struma ovarii is a rare form of ovarian neoplasm and its malignant transformation is even rarer.
  • Because of its rarity, there is no consensus about its diagnosis and management in the literature.
  • Postoperatively, she was diagnosed with a malignant struma ovarii.
  • Postoperative thyroid ultrasonography revealed a 0.5-cm solid nodule in the thyroid gland and total thyroidectomy was done.
  • Pathology report was nodular hyperplasia of benign character.
  • She is currently disease-free for 1 year but long-term follow-up with thyroglobulin levels is necessary due to reports of increasing recurrence rates.
  • [MeSH-major] Carcinoma, Papillary / pathology. Ovarian Neoplasms / pathology. Struma Ovarii / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Female. Humans. Hysterectomy. Middle Aged. Thyroid Gland / ultrasonography


80. Mattucci ML, Dellera A, Guerriero A, Barbieri F, Minnelli L, Furlani L: Malignant struma ovarii: a case report and review of the literature. J Endocrinol Invest; 2007 Jun;30(6):517-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant struma ovarii: a case report and review of the literature.
  • Malignant struma ovarii is a very rare disease.
  • We describe a case of malignant struma ovarii, in a 37 year-old female who presented for non cyclic, chronic pelvic pain and the presence of a right ovarian cyst with mean diameter of 7 cm.
  • The patient was treated with laparoscopic right ovariectomy and with multiple biopsies of omental, left ovary and utero-sacral ligament.
  • A Medline literature search was performed; we found 48 cases of malignant struma ovarii.
  • The therapeutic management of the disease is very different in the described case; particularly after surgical removing of the ovarian mass, the treatment is still controversial.
  • We think that the management of malignant struma ovarii could be the same than carcinoma of the thyroid, so after surgical removing of ovarian neoplasm, we recommend thyroidectomy, radiotherapy with 131I and levothyroxine suppressive therapy.
  • [MeSH-major] Ovarian Neoplasms. Struma Ovarii

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  • (PMID = 17646728.001).
  • [ISSN] 1720-8386
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
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81. Roth LM, Talerman A: The enigma of struma ovarii. Pathology; 2007 Feb;39(1):139-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The enigma of struma ovarii.
  • Since its first description in the early part of the twentieth century, struma ovarii has elicited considerable interest because of its many unique features; however, at present a number of aspects remain enigmatic.
  • Uncommon macroscopic and especially histological patterns in struma can cause difficulties in diagnosis.
  • Proliferative changes within struma can be misdiagnosed as cancer.
  • In regard to the occurrence of thyroid-type carcinoma in struma ovarii, precise terminology should be utilised, and the term 'malignant struma ovarii' should be avoided because it has been used for several different pathological entities.
  • Papillary carcinoma is the most commonly occurring thyroid-type carcinoma in ovarian struma; however, cases of follicular carcinoma are not infrequent.
  • Histological malignancy in struma does not necessarily equate with biological malignancy, and the majority of thyroid-type carcinomas do not spread beyond the ovary.
  • Strumal carcinoid, a neoplasm apparently unique to the ovary containing elements of both struma and carcinoid, has been misdiagnosed as 'malignant struma ovarii' in the past.
  • The differential diagnosis of extra-ovarian spread of struma includes the usual types of thyroid cancer, minimal deviation follicular carcinoma, and peritoneal strumosis.
  • This review emphasises articles both recent and past that have significantly advanced our knowledge of struma ovarii and related neoplasms.
  • [MeSH-major] Ovarian Neoplasms / pathology. Struma Ovarii / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans

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  • (PMID = 17365830.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 53
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82. Stekelenburg J, Brugge HG, Moll FC, Dompeling EC: [Malignant struma ovarii]. Ned Tijdschr Geneeskd; 2008 Mar 22;152(12):701-4
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  • [Title] [Malignant struma ovarii].
  • [Transliterated title] Maligne struma ovarii.
  • A 46-year-old patient underwent exploratory laparotomy due to indications of ovarian malignancy.
  • Histopathological examination of postoperative specimens revealed malignant struma ovarii, a very rare condition.
  • The patient had a low risk of disease progression (T1>1cmN0M0).
  • Management consisted of initial conservative follow-up, which included administration of thyroid-stimulating hormone (TSH) suppression therapy with levothyroxine.
  • [MeSH-major] Ovarian Neoplasms / diagnosis. Struma Ovarii / diagnosis. Thyroxine / administration & dosage

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  • [CommentIn] Ned Tijdschr Geneeskd. 2008 Jul 19;152(29):1647; author reply 1647-8 [18998275.001]
  • (PMID = 18438067.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 9002-71-5 / Thyrotropin; Q51BO43MG4 / Thyroxine
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83. Shanbhogue AK, Shanbhogue DK, Prasad SR, Surabhi VR, Fasih N, Menias CO: Clinical syndromes associated with ovarian neoplasms: a comprehensive review. Radiographics; 2010 Jul-Aug;30(4):903-19
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  • [Title] Clinical syndromes associated with ovarian neoplasms: a comprehensive review.
  • Functional ovarian neoplasms have unique clinical manifestations related to hormone overproduction and may give rise to a broad spectrum of clinical syndromes.
  • Sex cord-stromal tumors, the most common functional ovarian neoplasms, are associated with either hyperestrogenism (as in granulosa cell tumor and thecoma) or hyperandrogenism (as in Sertoli-Leydig cell tumor and Leydig cell tumor).
  • Other, less common ovarian neoplasms that may have endocrine or nonendocrine syndromic manifestations include germ cell tumors associated with the excessive production of human chorionic gonadotropin (eg, choriocarcinoma, dysgerminoma), monodermal teratomas (eg, carcinoid tumor, struma ovarii) associated with carcinoid syndrome and hyperthyroidism, and primary epithelial ovarian cancers associated with paraneoplastic syndromes.
  • The application of diagnostic algorithms based on patient demographic information, clinical manifestations, laboratory findings, and cross-sectional imaging features may help identify ovarian neoplasms in complex clinical settings.
  • [MeSH-major] Diagnostic Imaging / methods. Endocrine System Diseases / diagnosis. Ovarian Neoplasms / diagnosis. Paraneoplastic Syndromes / diagnosis

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  • (PMID = 20631359.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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84. Waugh MS, Soler AP, Robboy SJ: Silent corticotroph cell pituitary adenoma in a struma ovarii. Int J Gynecol Pathol; 2007 Jan;26(1):26-9
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  • [Title] Silent corticotroph cell pituitary adenoma in a struma ovarii.
  • This is the first report of a silent corticotroph cell pituitary adenoma arising in a struma ovarii.
  • The patient, a 79-year-old woman, was found to have an asymptomatic left-sided adnexal mass confirmed by vaginal sonography to be a complex cystic and solid tumor.
  • Pathological analysis demonstrated an 8-cm partially cystic struma ovarii in which there was a focus of predominantly basophilic adenohypophyseal cells arranged in a diffuse pattern, adjacent to mature neural tissue containing numerous Herring bodies.
  • [MeSH-major] ACTH-Secreting Pituitary Adenoma / pathology. Corticotrophs / pathology. Struma Ovarii / pathology

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  • (PMID = 17197893.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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85. Lim ST, Jeong HJ, Chung MJ, Yim CY, Sohn MH: Malignant struma ovarii demonstrated on post-therapy radioiodine scan after total thyroidectomy for papillary thyroid cancer. Clin Nucl Med; 2008 Jun;33(6):429-31
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  • [Title] Malignant struma ovarii demonstrated on post-therapy radioiodine scan after total thyroidectomy for papillary thyroid cancer.
  • [MeSH-major] Adenocarcinoma, Papillary / secondary. Adenocarcinoma, Papillary / therapy. Iodine Radioisotopes. Ovarian Neoplasms / radionuclide imaging. Ovarian Neoplasms / secondary. Thyroid Neoplasms / therapy. Thyroidectomy


86. Royo P, Alcazar JL, Virgen M, Mazaira J, Jurado M, Lopez G: B-mode and Doppler features of struma ovarii. Ultrasound Obstet Gynecol; 2008 Jan;31(1):109-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] B-mode and Doppler features of struma ovarii.
  • [MeSH-major] Ovarian Neoplasms / ultrasonography. Struma Ovarii / ultrasonography

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  • (PMID = 18098342.001).
  • [ISSN] 0960-7692
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] England
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87. Guida M, Mandato VD, Di Spiezio Sardo A, Di Carlo C, Giordano E, Nappi C: Coexistence of Graves' disease and benign struma ovarii in a patient with marked ascites and elevated CA-125 levels. J Endocrinol Invest; 2005 Oct;28(9):827-30
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  • [Title] Coexistence of Graves' disease and benign struma ovarii in a patient with marked ascites and elevated CA-125 levels.
  • BACKGROUND: Struma ovarii is the most common monodermal ovarian teratoma and consists mainly of thyroid tissue.
  • Only 5% of patients with this tumor have features of hyperthyroidism.
  • The pathophysiology of hyperthyroidism in struma ovarii is not clear.
  • CASE: We describe a case of benign struma ovarii, presenting with the clinical features of an ovarian cancer: large complex pelvic mass, large amount of ascites and markedly elevated CA-125 serum levels.
  • The patient was initially treated for Graves' disease, on the basis of ultrasonographic, laboratoristic and scintigraphic evidence.
  • A large pelvic mass was then diagnosed which, at the pathologic examination, was diagnosed as a struma ovarii.
  • CONCLUSION: The struma ovarii always has to be considered when a pelvic mass is associated with features of hyperthyroidism.
  • [MeSH-major] CA-125 Antigen / blood. Graves Disease / etiology. Graves Disease / therapy. Ovarian Neoplasms / etiology. Ovarian Neoplasms / surgery. Struma Ovarii / etiology. Struma Ovarii / surgery

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  • (PMID = 16370564.001).
  • [ISSN] 0391-4097
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / CA-125 Antigen; 554Z48XN5E / Methimazole; Q51BO43MG4 / Thyroxine
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88. Mui MP, Tam KF, Tam FK, Ngan HY: Coexistence of struma ovarii with marked ascites and elevated CA-125 levels: case report and literature review. Arch Gynecol Obstet; 2009 May;279(5):753-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Coexistence of struma ovarii with marked ascites and elevated CA-125 levels: case report and literature review.
  • INTRODUCTION: Struma ovarii is a rare form of ovarian neoplasm and consists mainly of thyroid tissue.
  • However, the combination of struma ovarii and elevated CA-125 has rarely been reported.
  • MATERIALS AND METHODS: We described a case of benign struma ovarii, presenting with the clinical features of ovarian cancer: large complex pelvic mass, gross ascites and markedly elevated serum CA-125 levels.
  • Surgical excision of the ovarian mass was followed by rapid resolution of the ascites and reduction of the serum CA-125 level.
  • CONCLUSION: Struma ovarii can mimic ovarian malignancy clinically, when presented with ascites and an elevated CA-125 level.
  • [MeSH-major] Ascites / blood. CA-125 Antigen / blood. Struma Ovarii / blood
  • [MeSH-minor] Biomarkers, Tumor / blood. Female. Humans. Middle Aged. Ovarian Neoplasms / blood. Ovarian Neoplasms / complications. Ovarian Neoplasms / pathology

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  • (PMID = 18807056.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-125 Antigen
  • [Number-of-references] 23
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89. Janszen EW, van Doorn HC, Ewing PC, de Krijger RR, de Wilt JH, Kam BL, de Herder WW: [Malignant struma ovarii]. Ned Tijdschr Geneeskd; 2008 Jul 19;152(29):1647; author reply 1647-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Malignant struma ovarii].
  • [Transliterated title] Maligne struma ovarii.
  • [MeSH-major] Decision Making. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / surgery. Struma Ovarii / diagnosis. Struma Ovarii / surgery

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  • [CommentOn] Ned Tijdschr Geneeskd. 2008 Mar 22;152(12):701-4 [18438067.001]
  • (PMID = 18998275.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Comment; Letter
  • [Publication-country] Netherlands
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90. Macdonald W, Armstrong J: Benign struma ovarii in a patient with invasive papillary thyroid cancer: detection with I-131 SPECT-CT. Clin Nucl Med; 2007 May;32(5):380-2
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  • [Title] Benign struma ovarii in a patient with invasive papillary thyroid cancer: detection with I-131 SPECT-CT.
  • [MeSH-major] Iodine Radioisotopes. Ovarian Neoplasms / secondary. Ovary / radionuclide imaging. Struma Ovarii / diagnosis. Struma Ovarii / radionuclide imaging. Tomography, Emission-Computed, Single-Photon / methods
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / radionuclide imaging. Aged. Carcinoma, Papillary / pathology. Female. Humans. Thyroglobulin / metabolism. Thyroid Neoplasms / pathology. Thyroidectomy. Thyrotropin / metabolism. Tomography, X-Ray Computed / methods

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  • (PMID = 17452868.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 9002-71-5 / Thyrotropin; 9010-34-8 / Thyroglobulin
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91. Kunstmann L, Bständig B, Brucker-Davis F, Mouroux J, Rigot P, Fenichel P: [Malignant struma ovarii: false positive PET image for suspected metastasis due to sarcoidosis]. Ann Endocrinol (Paris); 2007 Feb;68(1):51-4
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  • [Title] [Malignant struma ovarii: false positive PET image for suspected metastasis due to sarcoidosis].
  • [Transliterated title] Goitre ovarien malin: faux positif du TEP-scan lié à une sarcoïdose.
  • Struma ovarii is an ovarian teratoma mainly composed of thyroid tissue, which can become malignant with possible peritoneal dissemination or even distant metastases.
  • Therapeutic management follows protocols used for thyroid cancer.
  • We report the first use of (18)F-fluorodeoxyglucose positron emission tomography (PET) in the follow-up of malignant struma ovarii with persistently elevated serum thyroglobulin level and negative diagnostic iodine 131 whole body scan after thyroidectomy and four courses of 131 iodine.
  • [MeSH-major] Ovarian Neoplasms / radionuclide imaging. Positron-Emission Tomography. Sarcoidosis / radionuclide imaging
  • [MeSH-minor] Adult. False Positive Reactions. Female. Fluorodeoxyglucose F18. Humans. Radiopharmaceuticals. Thyroid Gland / pathology

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  • (PMID = 17313936.001).
  • [ISSN] 0003-4266
  • [Journal-full-title] Annales d'endocrinologie
  • [ISO-abbreviation] Ann. Endocrinol. (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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92. Wolff EF, Hughes M, Merino MJ, Reynolds JC, Davis JL, Cochran CS, Celi FS: Expression of benign and malignant thyroid tissue in ovarian teratomas and the importance of multimodal management as illustrated by a BRAF-positive follicular variant of papillary thyroid cancer. Thyroid; 2010 Sep;20(9):981-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of benign and malignant thyroid tissue in ovarian teratomas and the importance of multimodal management as illustrated by a BRAF-positive follicular variant of papillary thyroid cancer.
  • BACKGROUND: The most common type of ovarian germ cell tumor is the teratoma.
  • Thyroid tissue, both benign and malignant, may be a component of an ovarian teratoma.
  • Here we review this topic and illustrate major features by presenting multimodal management of a patient with BRAF-positive disseminated follicular thyroid cancer arising in an ovarian teratoma.
  • SUMMARY: Malignant thyroid tissue is often difficult to distinguish from benign thyroid tissue arising in ovarian teratomas.
  • Preoperatively, an elevated thyroglobulin (Tg) level, laboratory or clinical evidence of hyperthyroidism, or ultrasonography appearance of "struma pearl" should prompt referral to oncologist for surgical management of a possibly malignant ovarian teratoma.
  • Postoperatively, tumor tissue should be referred to pathologists experienced with differentiating benign from malignant struma ovarii.
  • We cared for woman with disseminated thyroid cancer arising in an ovarian teratoma whose history illustrates the complexity of managing ovarian teratomas with malignant thyroid tissue.
  • At age 33 she had an intraoperative rupture of an ovarian cyst, thought to be struma ovarii.
  • During her next pregnancy, pelvic masses were noted; biopsies revealed well-differentiated papillary thyroid carcinoma, follicular variant.
  • She then developed abdominal pain and, on computed tomography, was found to have multiple intraabdominal foci of disease.
  • The tumor was found to be BRAF mutation positive (K601E).
  • CONCLUSIONS: Aggressive multimodal management appears to be the most promising approach for malignant thyroid tissue arising in ovarian teratomas.


93. Yücesoy G, Cakiroglu Y, Muezzinoglu B, Besnili B, Yucesoy I: Malignant struma ovarii: a case report. J Korean Med Sci; 2010 Feb;25(2):327-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant struma ovarii: a case report.
  • We present a case of a 40-yr-old woman diagnosed with a primary malignant struma ovarii.
  • Pre-operative tumor markers and routine biochemistry were unremarkable.
  • Post-operatively, she was diagnosed with a malignant struma ovarii through the usage of histopathological criteria similar to the guidelines for primary thyroid gland disease.
  • Although, left ovary and lymph nodes were histopathologically normal, she was offered thyroidectomy but she refused to accept the offer.
  • She is free of the disease for 18 months.
  • [MeSH-major] Ovarian Neoplasms / diagnosis. Struma Ovarii / diagnosis

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  • (PMID = 20119594.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 9010-34-8 / Thyroglobulin
  • [Other-IDs] NLM/ PMC2811308
  • [Keywords] NOTNLM ; Struma Ovarii / Thyroglobulin / Whole Body Imaging
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94. McGill JF, Sturgeon C, Angelos P: Metastatic struma ovarii treated with total thyroidectomy and radioiodine ablation. Endocr Pract; 2009 Mar;15(2):167-73
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  • [Title] Metastatic struma ovarii treated with total thyroidectomy and radioiodine ablation.
  • OBJECTIVE: To present a rare case of metastatic struma ovarii, review the related literature, and discuss the management.
  • METHODS: A case report of a patient with metastatic struma ovarii is presented.
  • We conducted a MEDLINE search of the English-language literature seeking additional cases of metastatic struma ovarii.
  • In addition to the current case, the previous 40 cases of metastatic struma ovarii were reviewed and analyzed.
  • All patients underwent resection of the primary tumor.
  • The most common sites of involvement for struma ovarii metastatic disease have been the peritoneum, mesentery, and omentum.
  • After primary tumor resection, a wide range of additional treatments have been used, including chemotherapy, resection of metastatic disease, external beam radiation therapy, and radioiodine ablation.
  • CONCLUSION: In cases of metastatic struma ovarii, we recommend total thyroidectomy in conjunction with radioiodine scanning and radioiodine ablation.
  • Thyroglobulin levels should be followed as a tumor marker, and diagnostic radioiodine scans should be performed to screen for residual or recurrent disease.
  • Although this treatment strategy is well established for thyroid cancer, long-term outcomes of this treatment for struma ovarii are still unknown.
  • [MeSH-major] Iodine Radioisotopes / therapeutic use. Neoplasm Metastasis / radiotherapy. Struma Ovarii / radiotherapy. Struma Ovarii / surgery. Thyroidectomy / methods

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  • (PMID = 19289330.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
  • [Number-of-references] 38
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95. Halpenny DF, O'Brien J, Ibrahim MM, Crotty R, Torreggiani WC: An unusual cause of pelvic pain: struma ovarii. JBR-BTR; 2009 Sep-Oct;92(5):239-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An unusual cause of pelvic pain: struma ovarii.
  • Following excision, histological examination revealed a lesion with mature teratomatous elements but with a significant component (> 50%) being composed of mature thyroid tissue.
  • A 2cm area within the lesion had the morphological pattern of a classical papillary thyroid carcinoma.
  • A diagnosis of struma ovarii was made.
  • Struma ovarii is a rare ovarian neoplasm generally arising in a teratoma and accounts for less than 1% all ovarian neoplasms.
  • Here we present the above case of struma ovarii in a young patient and discuss the radiological characteristics of the disease.
  • [MeSH-major] Ovarian Neoplasms / complications. Pelvic Pain / etiology. Struma Ovarii / complications
  • [MeSH-minor] Ablation Techniques. Diagnosis, Differential. Dysmenorrhea / etiology. Female. Follow-Up Studies. Humans. Iodine Radioisotopes. Magnetic Resonance Imaging. Ovary / pathology. Ovary / surgery. Ovary / ultrasonography. Rare Diseases. Thyroid Gland / surgery. Thyroid Gland / ultrasonography. Thyroidectomy. Young Adult

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  • (PMID = 19999326.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
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96. Shaco-Levy R, Bean SM, Bentley RC, Robboy SJ: Natural history of biologically malignant struma ovarii: analysis of 27 cases with extraovarian spread. Int J Gynecol Pathol; 2010 May;29(3):212-27
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Natural history of biologically malignant struma ovarii: analysis of 27 cases with extraovarian spread.
  • The natural history of 27 cases of biologically malignant struma ovarii from a series of 88 cases of histologically malignant or histologically proliferative struma ovarii is described.
  • The tumors measured 5 to 24.5 cm and were more than 50% thyroid tissue in all but 2 cases.
  • The microscopic diagnosis of the thyroid tissue was follicular adenoma in 17 cases (63%), papillary carcinoma in 7 (26%), unremarkable in 2 (7%), and follicular carcinoma in 1 case (4%).
  • Clinical features predictive of biologic malignancy were the presence of adhesions, peritoneal fluid (> or = 1 L), or a serosal rent in the struma ovarii (including cystectomy).
  • On last follow-up 3 patients (11%) had no evidence of disease, 9 (33%) were alive with disease, 5 (19%) died of other causes, and 10 patients (37%) died of the disease.
  • Death from disease occurred 1.5 to 32 years after diagnosis (mean=14 yr).
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Ovarian Neoplasms / pathology. Struma Ovarii / pathology

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  • (PMID = 20407319.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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97. Porpora MG, Pallante D, Ferro A, Alò PL, Cosmi EV: Asymptomatic struma ovarii: a case report. Clin Exp Obstet Gynecol; 2005;32(3):197-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Asymptomatic struma ovarii: a case report.
  • Struma ovarii is a rare ovarian neoplasm.
  • This tumor is generally benign, although malignant transformation has been reported.
  • The preoperative diagnosis is generally difficult.
  • Thyroid hormones may be produced and in a few cases asymptomatic women may develop definitive clinical hypothyroidism after resection of struma ovarii.
  • We report a case of a 39-year-old woman who underwent laparoscopic resection of an asymptomatic right ovarian mass.
  • The pathologic diagnosis was struma ovarii.
  • The postoperative period was uneventful and her thyroid function remained normal.
  • [MeSH-major] Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / surgery. Struma Ovarii / diagnosis. Struma Ovarii / surgery
  • [MeSH-minor] Adult. Female. Humans. Laparoscopy. Ovary / surgery. Ovary / ultrasonography. Treatment Outcome

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  • (PMID = 16433164.001).
  • [ISSN] 0390-6663
  • [Journal-full-title] Clinical and experimental obstetrics & gynecology
  • [ISO-abbreviation] Clin Exp Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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98. Netters FJ, van Oven MW, van Loon AJ, Hoogenberg K: [Struma ovarii during pregnancy]. Ned Tijdschr Geneeskd; 2008 Jun 7;152(23):1335-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Struma ovarii during pregnancy].
  • [Transliterated title] Struma ovarii tijdens de zwangerschap.
  • At 16-weeks gestation a left-sided unilateral ovarian cyst was discovered.
  • Histological examination showed a struma ovarii, a rare mature ovarian teratoma mainly consisting of thyroid tissue.
  • [MeSH-major] Ovarian Neoplasms / surgery. Pregnancy Complications, Neoplastic / surgery. Struma Ovarii / surgery

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  • (PMID = 18661861.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
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99. López Gallardo G, Del Rey MD, Aguirre Sánchez-Covisa M: Thyrotoxicosis and low iodine uptake in a woman with graves' disease. Endocrinol Nutr; 2008 Oct;55(9):436-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thyrotoxicosis and low iodine uptake in a woman with graves' disease.
  • Thyrotoxicosis factitia is defined as thyrotoxicosis resulting from exogenous ingestion of thyroid hormone, usually in patients with a psychiatric disorder.
  • Diagnosis can be difficult and this entity should be suspected in patients with high free tiroxine (T4) concentrations, low or suppressed thyroglobulin concentrations, normal urinary iodide excretion and low or suppressed (131)I uptake.
  • To establish the differential diagnosis, thyrotoxicosis factitia must be distinguished from several diseases with low (131)I uptake, such as Graves' disease, subacute thyroiditis, hyperthyroidism due to excessive iodine intake, struma ovarii and metastasis from thyroid cancer.

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  • [Copyright] Copyright © 2008 Sociedad Española de Endocrinología y Nutrición. Published by Elsevier Espana. All rights reserved.
  • (PMID = 22974457.001).
  • [ISSN] 1575-0922
  • [Journal-full-title] Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición
  • [ISO-abbreviation] Endocrinol Nutr
  • [Language] eng; spa
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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100. Takeuchi K, Ohbayashi C, Kitazawa S, Ohara N, Maruo T: Coexistence of brenner tumor and struma ovarii: case report. Eur J Gynaecol Oncol; 2005;26(1):109-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Coexistence of brenner tumor and struma ovarii: case report.
  • It is generally accepted that Brenner tumors are derived directly from ovarian surface epithelium, which undergoes metaplasia to form the typical urothelial-like components, whereas some investigators assume that Brenner tumors arise from immature germ cells.
  • CASE: We describe a well-documented case of the coexistence of struma ovarii regarded as a form of teratoma and Brenner tumor in the same ovary.
  • Immunohistologically, not only columnar cells of thyroid follicles, but also transitional cells of Brenner nests were positive for thyroglobulin.
  • CONCLUSIONS: In the present case, Brenner tumors and thyroid elements coexisted and were positive for thyroglobulin.
  • While there is strong evidence that pure Brenner tumors originate mostly from the ovarian surface, at least Brenner tumors associated with teratomatous elements may have a germ cell origin.
  • [MeSH-major] Brenner Tumor / diagnosis. Neoplasms, Multiple Primary / diagnosis. Ovarian Neoplasms / diagnosis. Struma Ovarii / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Uterine Hemorrhage / etiology

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  • (PMID = 15755015.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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