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1. Aydinli U, Ozturk C, Bayram S, Sarihan S, Evrensel T, Yilmaz HS: Evaluation of lung cancer metastases to the spine. Acta Orthop Belg; 2006 Oct;72(5):592-7
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  • A variety of benign and malignant tumours may arise in the lung, but the vast majority is bronchogenic carcinomas (90 to 95%).
  • Between the years 1995 and 2003, 168 lung cancer patients with metastatic spinal tumour who had received radiotherapy and chemotherapy were retrospectively evaluated.
  • Squamous cell carcinoma and adenocarcinoma are the lung cancers that mostly metastasise to vertebrae.
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Carcinoma, Bronchogenic / pathology. Carcinoma, Squamous Cell / pathology. Female. Humans. Male. Middle Aged. Retrospective Studies. Thoracic Vertebrae

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  • (PMID = 17152424.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
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2. Pepper T, Shekar K, Singh M, Brennan PA: Squamous cell carcinoma arising in mucosal plasmacytosis. Br J Oral Maxillofac Surg; 2010 Apr;48(3):208-10
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  • [Title] Squamous cell carcinoma arising in mucosal plasmacytosis.
  • The authors present an unusual case of invasive squamous cell carcinoma (SCC) developing in a pre-existing plasmacytosis of the lip.
  • The roles of chronic inflammation, immunosuppression, and smoking in the pathogenesis of this tumour are briefly discussed.
  • The authors highlight a significant side effect of the use of immunosuppressive drugs in benign conditions.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Lip Diseases / pathology. Lip Neoplasms / pathology. Lymphocytosis / pathology. Plasma Cells / pathology

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  • [Copyright] 2009 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20045232.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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3. Oremek GM, Sauer-Eppel H, Bruzdziak TH: Value of tumour and inflammatory markers in lung cancer. Anticancer Res; 2007 Jul-Aug;27(4A):1911-5
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  • [Title] Value of tumour and inflammatory markers in lung cancer.
  • The aim of this study was to evaluate the individual diagnostic utility of tumour and inflammatory markers in patients with different pulmonary diseases.
  • The usefulness of neuron-specific enolase (NSE), carcino-embryonic antigen (CEA), serum pro-gastrin releasing peptide (ProGRP) and CYFRA 21-1, as tumour markers, and C-reactive protein (CRP) and tumour necrosis factor-alpha (TNFalpha) as inflammatory markers for diagnosis, treatment and monitoring of patients with different pulmonary afflictions was investigated.
  • Moreover, serum marker levels were analyzed in 139 patients with different pulmonary malignancies: 29 patients with adenocarcinoma, 30 patients with squamous cell carcinoma, 80 patients with small cell lung cancer (SCLC).
  • All tumour markers showed significantly elevated values in malignant diseases.
  • The levels of ProGRP in patients with benign diseases were significantly higher than those in the healthy group (35.4 +/- 6.6 compared with 21.3 +/- 9.2 pg/ml respectively).
  • The elevation was significantly higher than that of the benign reference group.
  • Serum CRP levels were significantly higher in patients with SCLC (38.5 +/- 7.6 mg/dl) than in the benign reference group.
  • In conclusion, when serum tumour markers are abnormally elevated in patients with lung cancer, CEA, CYFRA 21-1, NSE and ProGRP are useful clinical markers, good indicators of disease extent and may have important prognostic value.
  • [MeSH-major] Biomarkers, Tumor / blood. Inflammation / blood. Lung Neoplasms / diagnosis
  • [MeSH-minor] Antigens, Neoplasm / blood. Area Under Curve. C-Reactive Protein / analysis. Carcinoembryonic Antigen / blood. Carcinoma, Non-Small-Cell Lung / blood. Carcinoma, Non-Small-Cell Lung / diagnosis. Carcinoma, Small Cell / blood. Carcinoma, Small Cell / diagnosis. Carcinoma, Squamous Cell / blood. Carcinoma, Squamous Cell / diagnosis. Humans. Immunoassay. Keratin-19. Keratins / blood. Lung Diseases / blood. Lung Diseases / diagnosis. Peptide Fragments / blood. Peptides / blood. Phosphopyruvate Hydratase / blood. ROC Curve. Recombinant Proteins / blood. Sensitivity and Specificity. Tumor Necrosis Factor-alpha / blood

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  • (PMID = 17649794.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen; 0 / Keratin-19; 0 / Peptide Fragments; 0 / Peptides; 0 / Recombinant Proteins; 0 / Tumor Necrosis Factor-alpha; 0 / antigen CYFRA21.1; 0 / pro-gastrin-releasing peptide (31-98); 68238-35-7 / Keratins; 9007-41-4 / C-Reactive Protein; EC 4.2.1.11 / Phosphopyruvate Hydratase
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4. Chao MW, Gibbs P: Squamous cell carcinoma arising in a giant condyloma acuminatum (Buschke-Lowenstein tumour). Asian J Surg; 2005 Jul;28(3):238-40
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  • [Title] Squamous cell carcinoma arising in a giant condyloma acuminatum (Buschke-Lowenstein tumour).
  • Giant condyloma acuminatum (GCA) is a tumour that primarily affects the genital and perianal areas.
  • Despite the histologically benign appearance, it behaves in a malignant fashion, destroying adjacent tissues, and is regarded as an entity intermediate between an ordinary condyloma acuminatum and squamous cell carcinoma.
  • Primary anorectal lesions account for only a small number of GCA cases and, as with squamous cell carcinoma, the human papilloma virus is the causative agent.
  • The hallmark of GCA is the high rate of local recurrence and transformation into squamous cell carcinoma.


5. Bandyopadhyay A, Das TK, Raha K, Hati GC, Mitra PK, Dasgupta A: A study of fine needle aspiration cytology of salivary gland lesions with histopathological corroboration. J Indian Med Assoc; 2005 Jun;103(6):312-4, 316
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  • All smears were evaluated according to cell size, amount of cytoplasm, cytologic atypia and presence of lymphocytes. (a) Variable cytologic appearances of pleomorphic salivary adenoma were observed. (b) Cellular pleomorphic adenoma and adenoid cystic carcinoma showed basaloid cell features. (c) Tumours with intermediate size cells and bland cytology included low grade muco-epidermoid carcinoma and cystic lesions. (d) Warthin's tumour, oncocytoma, salivary duct carcinoma and high grade muco-epidermoid carcinoma revealed large cells and abundant cytoplasm with or without atypia.
  • A major diagnostic categories were inflammatory lesions (n = 7 5), cystic lesions (n = 9), benign tumours (n = 81), malignant neoplasms (n = 1 8) and normal acinar pattern (n = 2).
  • Malignant tumours included muco-epidermoid carcinoma (n = 5), adenoid cystic carcinoma (n = 3), acinic cell carcinoma (n = 2), adenocarcinoma (n= 2), squamous cell carcinoma (n = 1), undifferentiated carcinoma (n= 4) and malignant lymphoma (n = 1).
  • Histopathological correlation was possible in 40% of benign and 80% of malignant neoplasms.

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  • (PMID = 16225156.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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6. Van Lierop AC, Fagan JJ: Parotidectomy in Cape Town--a review of pathology and management. S Afr J Surg; 2007 Aug;45(3):96-8, 100, 102-3
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  • Pleomorphic adenoma was the most common benign tumour and metastatic cutaneous squamous cell carcinoma (SCC) was the most common malignancy.
  • Warthin's tumour had an equal gender distribution.

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  • [CommentIn] S Afr J Surg. 2007 Nov;45(4):152; author reply 152 [18069585.001]
  • (PMID = 17892188.001).
  • [ISSN] 0038-2361
  • [Journal-full-title] South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie
  • [ISO-abbreviation] S Afr J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] South Africa
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7. Kozlowski M, Kowalczuk O, Milewski R, Chyczewski L, Niklinski J, Laudański J: Serum vascular endothelial growth factors C and D in patients with oesophageal cancer. Eur J Cardiothorac Surg; 2010 Sep;38(3):260-7
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  • METHODS: Serum VEGF-C and sVEGF-D were measured by enzyme-linked immunoadsorbent assay (ELISA) on 149 patients with oesophageal cancer, 29 patients with benign oesophageal diseases and 30 healthy controls.
  • RESULTS: Serum VEGF-C and sVEGF-D levels were significantly higher in patients with oesophageal carcinoma than in the control group (p<0.001 and p=0.001, respectively) or in the benign oesophageal diseases group (p=0.04 and p=0.03, respectively).
  • Subgroup analysis showed that lymph node metastasis (p=0.001), stage (p=0.001), tumour depth (p=0.006), resectability (p=0.002), tumour size (p=0.01), distant metastases (p=0.01) and histological grading (p=0.04) were correlated with an elevated level of sVEGF-C.
  • Elevated levels of sVEGF-D were associated with tumour depth (p=0.002), stage (p=0.01) and lymph node metastasis (p=0.02).
  • On univariate regression analysis, tumour size, tumour depth, stage, lymph node metastases, distant metastases, resectability and sVEGF-C were found to be significant prognostic factors.
  • [MeSH-major] Biomarkers, Tumor / blood. Esophageal Neoplasms / diagnosis. Vascular Endothelial Growth Factor C / blood. Vascular Endothelial Growth Factor D / blood
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Diagnosis, Differential. Epidemiologic Methods. Esophageal Diseases / diagnosis. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Proteins / metabolism. Neoplasm Staging. Prognosis. Treatment Outcome

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  • [Copyright] Copyright 2010. Published by Elsevier B.V.
  • (PMID = 20226684.001).
  • [ISSN] 1873-734X
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Vascular Endothelial Growth Factor C; 0 / Vascular Endothelial Growth Factor D
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8. Niedzielska I, Sypniewski D, Mazurek U, Wilczok T, Niedzielski Z, Wziatek-Kuczmik D: Differential diagnosis of gingival hyperplasia based on IFN-gamma-stimulated gene expression using RT-PCR. Folia Biol (Praha); 2007;53(1):23-6
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  • Epulus is a benign gingival tumour of unknown aetiopathogenesis.
  • The literature does not present any molecular analysis of the tumour characteristics.
  • The purpose of the present study was to compare benign (epulus) and malignant (cancer) gingival hyperplasias with regard to the activity of the genes of apoptosis, proliferation, and inflammation using RT-PCR.
  • The investigation involved 70 patients with epuli and 15 patients with gingival squamous cell carcinoma.
  • Each subject had specimens collected from the tumour, tissue margin (incision line), and healthy tissue.
  • Correlations have been disclosed between apoptosis and proliferation genes expression in giant cell epuli and high-differentiated gingival squamous cell carcinoma.
  • In RT-PCR molecular analysis, giant cell epulus shows characteristics of a neoplastic lesion, while other epulus types seem to be inflammatory tumours.
  • [MeSH-minor] Diagnosis, Differential. Gene Expression Profiling. Humans. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17328839.001).
  • [ISSN] 0015-5500
  • [Journal-full-title] Folia biologica
  • [ISO-abbreviation] Folia Biol. (Praha)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 82115-62-6 / Interferon-gamma
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9. Kim JE, Kim HJ, Choi JM, Lee KH, Kim TY, Cho BK, Jung JY, Chung KY, Cho D, Park HJ: The antimicrobial peptide human cationic antimicrobial protein-18/cathelicidin LL-37 as a putative growth factor for malignant melanoma. Br J Dermatol; 2010 Nov;163(5):959-67
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  • METHODS: Human cationic antimicrobial protein-18 (hCAP-18)/LL-37 production in several cell lines including HaCaT, a chronic myelogenous leukaemia (CML) cell line and various melanoma cell lines was examined using reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay.
  • Immunohistochemical analysis of melanoma, nonmelanoma skin cancer and precancerous and benign skin lesions was performed.
  • After adding LL-37 to a melanoma cell line, tumour cell proliferation, migration and invasion were investigated.
  • RESULTS: Human malignant melanoma cell lines overexpressed hCAP-18/LL-37 mRNA and peptide compared with HaCaT and CML cell lines.
  • Immunohistochemistry showed that the peptide was strongly expressed in malignant melanoma and moderately expressed in squamous cell carcinoma, whereas basal cell carcinoma, precancerous lesions and seborrhoeic keratosis showed no or weak expression.
  • LL-37 also stimulated melanoma cell proliferation, migration and invasion in vitro.
  • LL-37 promoted melanoma cell proliferation, migration and invasion in vitro.
  • [MeSH-major] Antimicrobial Cationic Peptides / metabolism. Melanoma / metabolism. Neoplasm Proteins / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Line, Tumor / metabolism. Cell Movement / physiology. Cell Proliferation. Enzyme-Linked Immunosorbent Assay. Female. Humans. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology. Male. Middle Aged. Neoplasm Invasiveness / pathology. Precancerous Conditions / metabolism. RNA, Messenger / metabolism

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  • [Copyright] © 2010 The Authors. BJD © 2010 British Association of Dermatologists.
  • (PMID = 20977442.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimicrobial Cationic Peptides; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 143108-26-3 / CAP18 lipopolysaccharide-binding protein
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10. Parkins GE, Armah GA, Tettey Y: Orofacial tumours and tumour-like lesions in Ghana: a 6-year prospective study. Br J Oral Maxillofac Surg; 2009 Oct;47(7):550-4
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  • [Title] Orofacial tumours and tumour-like lesions in Ghana: a 6-year prospective study.
  • A total of 182 patients with orofacial tumours and tumour-like lesions who attended the oral and maxillofacial surgical department of the Korle-Bu Teaching Hospital, Accra, were studied from 1 January 1998 to 31 December 2003.
  • Both malignant and benign tumours were recorded and were more common among men (99/182, 54%) in whom they were seen most often between the ages of 41 and 70 years.
  • A total of 108 tumours were diagnosed as malignant (59%), 27 (15%) as benign odontogenic tumours, and 47 (26%) as benign non-odontogenic and tumour-like lesions.
  • Malignant tumours were usually detected in men between the ages of 41 and 70 years (43% of all men); whilst benign tumours were evenly distributed between the sexes with more among girls in the 11-20 year age group.
  • The most common malignant tumours were squamous cell carcinoma (SCC), (69/108, 64%) and lymphomas (18/108, 17%).
  • The predominant benign odontogenic and non-odontogenic tumours were ameloblastoma and fibro-osseous lesions, respectively.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Ameloblastoma / epidemiology. Carcinoma, Squamous Cell / epidemiology. Child. Child, Preschool. Female. Follow-Up Studies. Ghana / epidemiology. Humans. Lymphoma / epidemiology. Male. Mandibular Neoplasms / epidemiology. Maxillary Neoplasms / epidemiology. Middle Aged. Odontogenic Tumors / epidemiology. Palatal Neoplasms / epidemiology. Prospective Studies. Sex Factors. Young Adult

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  • (PMID = 19111945.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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11. Faleiro-Rodrigues C, Macedo-Pinto IM, Maia SS, Vieira RH, Lopes CS: Biological relevance of E-cadherin-catenin complex proteins in primary epithelial ovarian tumours. Gynecol Obstet Invest; 2005;60(2):75-83
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  • Immunohistochemistry was used to evaluate the expression of these proteins in 154 epithelial ovarian tumours, consisting of 17 benign, 33 borderline and 104 malignant tumours.
  • The immunoexpression pattern of beta-catenin associated with histological type and tumour differentiation (p = 0.005, p = 0.025, respectively).
  • The preserved phenotype of beta-catenin associated with endometrioid carcinomas, while reduced beta-catenin associated with poorly differentiated serous and clear cell carcinomas.
  • Although the reduced phenotype was the most frequent immunoexpression observed for all proteins of the E-cadherin-catenin complex in epithelial ovarian tumours, only beta-catenin showed a significant difference between benign, borderline and malignant tumours (p = 0.045), since borderline and malignant tumours most frequently showed the reduced phenotype.
  • The immunohistochemical profile of beta-catenin was shown to be of biological relevance: reduced beta-catenin was correlated with loss of tumour differentiation and serous carcinomas that are known to depict aggressive biological behaviour in epithelial ovarian tumours.
  • [MeSH-minor] Adenocarcinoma, Mucinous / metabolism. Adenocarcinoma, Mucinous / pathology. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Desmoplakins. Female. Humans. Immunohistochemistry. Middle Aged. alpha Catenin. beta Catenin. gamma Catenin

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  • [Copyright] Copyright (c) 2005 S. Karger AG, Basel.
  • (PMID = 15785075.001).
  • [ISSN] 0378-7346
  • [Journal-full-title] Gynecologic and obstetric investigation
  • [ISO-abbreviation] Gynecol. Obstet. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / CTNNA1 protein, human; 0 / CTNNB1 protein, human; 0 / Cadherins; 0 / Cytoskeletal Proteins; 0 / Desmoplakins; 0 / JUP protein, human; 0 / Trans-Activators; 0 / alpha Catenin; 0 / beta Catenin; 0 / gamma Catenin
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12. Cheah PL, Looi LM: Significance of Bcl-2 and Bax proteins in cervical carcinogenesis: an immunohistochemical study in squamous cell carcinoma and squamous intraepithelial lesions. Malays J Pathol; 2006 Jun;28(1):1-5
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  • [Title] Significance of Bcl-2 and Bax proteins in cervical carcinogenesis: an immunohistochemical study in squamous cell carcinoma and squamous intraepithelial lesions.
  • Sixteen low grade (LSIL), 22 high grade (HSIL) squamous intraepithelial lesions, 28 invasive (13 stage I and 15 stage II-IV) squamous cell carcinoma (SCC) and 15 benign cervices were immunohistochemically studied for involvement of Bcl-2 and Bax proteins in cervical carcinogenesis.
  • Bcl-2 was upregulated (p < 0.05) in HSIL and Bax in SCC when compared with benign cervical squamous epithelium.
  • Bcl-2 expression was confined to the lower third of the epithelium in the benign cervices and LSIL.
  • SCCs showed "diffuse" (evenly distributed) or "basal" (intensified staining around the periphery of the invading tumour nests) expression of Bcl-2.
  • Benign cervical squamous epithelium, LSIL, HSIL and SCC showed a generally diffuse Bax expression.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Squamous Cell / metabolism. Cervical Intraepithelial Neoplasia / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. Uterine Cervical Neoplasms / metabolism. bcl-2-Associated X Protein / metabolism

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  • (PMID = 17694953.001).
  • [ISSN] 0126-8635
  • [Journal-full-title] The Malaysian journal of pathology
  • [ISO-abbreviation] Malays J Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Malaysia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / bcl-2-Associated X Protein
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13. Shanks JH, Iczkowski KA: Divergent differentiation in urothelial carcinoma and other bladder cancer subtypes with selected mimics. Histopathology; 2009 Jun;54(7):885-900
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  • A variety of unusual architectural patterns of urothelial carcinoma, such as the nested, microcystic and inverted variants, can be mistaken for reactive processes or benign tumours.
  • Others such as the micropapillary, plasmacytoid and discohesive variants, can mimic metastatic tumour from other sites.
  • In addition, urothelial carcinoma has a propensity to demonstrate divergent differentiation with glandular, squamous, small cell neuroendocrine, lymphoepithelioma-like, sarcomatoid or other elements.
  • Pure squamous carcinoma or adenocarcinoma (the latter in particular) can be difficult to distinguish from contiguous or metastatic spread.
  • Sarcomatoid carcinoma and its differential diagnosis with other spindle cell lesions of urinary tract will be covered in a separate review.
  • [MeSH-minor] Adenocarcinoma, Clear Cell / diagnosis. Adenocarcinoma, Clear Cell / pathology. Adenoma / diagnosis. Adenoma / pathology. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / pathology. Carcinoma, Transitional Cell / diagnosis. Carcinoma, Transitional Cell / pathology. Cell Differentiation. Cystitis / diagnosis. Cystitis / pathology. Diagnosis, Differential. Giant Cell Tumors / diagnosis. Giant Cell Tumors / pathology. Humans. Neoplasm Metastasis / diagnosis. Neoplasm Metastasis / pathology. Neoplasms, Squamous Cell / diagnosis. Neoplasms, Squamous Cell / pathology. Neuroendocrine Tumors / diagnosis. Neuroendocrine Tumors / pathology. Radiation Injuries / diagnosis. Radiation Injuries / pathology. Urothelium / pathology

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  • (PMID = 19178589.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 152
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14. Aïda AK, Sana BS, Essia S, Carole GB, Ahlem LB, Amel T, Sabah MR: [Malignant degeneration of mature benign teratoma of the ovary: a case report]. Tunis Med; 2005 Nov;83(11):710-3
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  • [Title] [Malignant degeneration of mature benign teratoma of the ovary: a case report].
  • [Transliterated title] Degenerescence maligne des teratomes matures benins de l'ovaire: a propos d'un nouveau cas.
  • Malignant transformation of ovarian mature benign teratomas is an uncommon complication which often occurs in the postmenopausal period.
  • Clinical presentation is similar to that of benign ovarian cysts.
  • The diagnosis of malignant transformation is often made per-operatively by the break of the capsule and the adhesions of the tumor or during histological examination.
  • All histological forms can be met, but squamous cell carcinoma accounts for 75% of all cases.
  • We report the case of a 70-year-old woman who had a squamous cell carcinoma which developed on a teratoma of the ovary, for whom the disease was fatal.
  • The survival rate for this kind of ovarian tumour is reduced, with 15 to 30% survival after 5 years, irrespective of stages and histological types.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Neoplasms, Multiple Primary / pathology. Ovarian Neoplasms / pathology. Teratoma / pathology
  • [MeSH-minor] Aged. Cell Transformation, Neoplastic / pathology. Diagnosis, Differential. Fatal Outcome. Female. Humans. Lymphatic Metastasis / pathology. Ovarian Cysts / diagnosis


15. Oon HH, Kumarasinghe SP: Subungual squamous cell carcinoma masquerading as a melanotic macule. Singapore Med J; 2008 Mar;49(3):e76-7
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  • [Title] Subungual squamous cell carcinoma masquerading as a melanotic macule.
  • Subungual squamous cell carcinoma is a rare condition.
  • Diagnosis is often delayed because it presents with minimal nail changes and mimics a number of benign nail conditions.
  • Histology from a punch biopsy revealed a well-differentiated squamous cell carcinoma.
  • Physicians should have a high index of clinical suspicion as early nail biopsy and prompt tumour clearance can preserve joint function.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Nail Diseases / diagnosis. Skin Neoplasms / diagnosis


16. Tytherleigh MG, Birtle AJ, Cohen CE, Glynne-Jones R, Livingstone J, Gilbert J: Combined surgery and chemoradiation as a treatment for the Buschke-Löwenstein tumour. Surgeon; 2006 Dec;4(6):378-83
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  • [Title] Combined surgery and chemoradiation as a treatment for the Buschke-Löwenstein tumour.
  • BACKGROUND: The Buschke-Löwenstein tumour (BLT) or giant condyloma acuminata is a rare disease which affects the anogenital region.
  • Although histologically benign, it behaves in a malignant fashion, infiltrating the surrounding tissues.
  • The morbidity and mortality from this tumour is high, as is the risk of recurrence following treatment.
  • It lies on the continuum between the benign condylomata acuminata and squamous cell carcinoma.
  • Chemoradiation remains the mainstay of treatment for anal cancers but has not been routinely employed in the management of the BLT without squamous cell carcinoma transformation.
  • CONCLUSION: Pre-operative chemoradiation has proved to be useful in management for histologically proven benign BLT
  • [MeSH-minor] Abdominal Neoplasms / secondary. Abdominal Neoplasms / therapy. Adult. Anus Neoplasms / secondary. Anus Neoplasms / therapy. Carcinoma in Situ / pathology. Carcinoma in Situ / therapy. Carcinoma, Squamous Cell / therapy. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Fatal Outcome. Fluorouracil / administration & dosage. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Radiotherapy, Adjuvant. Rectal Neoplasms / secondary. Rectal Neoplasms / therapy

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  • (PMID = 17152203.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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17. Andreadis D, Epivatianos A, Mireas G, Nomikos A, Poulopoulos A, Yiotakis J, Barbatis C: Immunohistochemical detection of E-cadherin in certain types of salivary gland tumours. J Laryngol Otol; 2006 Apr;120(4):298-304
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  • MATERIAL AND METHODS: Archival formalin-fixed, paraffin-embedded sections of 54 benign and 56 malignant tumours and 24 samples of normal and inflamed salivary gland tissue were studied immunohistochemically using an Envision/horseraddish peroxidase (HRP) technique.
  • RESULTS: In normal and inflamed salivary gland samples, E-cadherin was expressed at the membrane of acinar, myoepithelial and ductal cells located at cell-cell contact points.
  • Furthermore, a weak to moderate loss of expression which was related to tissue tumour subtype was seen in malignant tumours such as: adenoid cystic carcinomas; polymorphous low-grade adenocarcinomas; acinic cell carcinomas; and mucoepidermoid low-grade, epithelial-myoepithelial, lymphoepithelial and squamous low-grade carcinomas.
  • Moderate to extreme loss or alternative cytoplasmic non-functional expression were observed in cases of salivary ductal carcinoma, carcinosarcoma, myoepithelial carcinoma, oncocytic adenocarcinoma, unspecified adenocarcinoma and squamous high-grade carcinomas.
  • [MeSH-major] Adenocarcinoma / chemistry. Biomarkers, Tumor / analysis. Cadherins / analysis. Carcinoma, Adenoid Cystic / chemistry. Carcinoma, Ductal / chemistry. Salivary Gland Neoplasms / metabolism

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  • (PMID = 16623973.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins
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18. Brennan PA, Davies B, Poller D, Mead Z, Bayne D, Puxeddu R, Oeppen RS: Fine needle aspiration cytology (FNAC) of salivary gland tumours: repeat aspiration provides further information in cases with an unclear initial cytological diagnosis. Br J Oral Maxillofac Surg; 2010 Jan;48(1):26-9
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  • METHODS: A retrospective study of 135 patients who had FNAC followed by definitive excision for a suspected salivary gland tumour.
  • The sensitivity (84%) and specificity (93%) of repeat FNAC in distinguishing benign from malignant tumours was similar to initial FNAC (70% and 95%, respectively).
  • [MeSH-minor] Adenolymphoma / pathology. Adenoma / pathology. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / secondary. Cytodiagnosis. Diagnosis, Differential. Humans. Lymphoma / pathology. Parotid Neoplasms / pathology. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity. Submandibular Gland Neoplasms / pathology. Ultrasonography, Interventional

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  • [Copyright] Copyright 2009 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 19233526.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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19. Nasir L, Campo MS: Bovine papillomaviruses: their role in the aetiology of cutaneous tumours of bovids and equids. Vet Dermatol; 2008 Oct;19(5):243-54
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  • In cattle BPVs induce benign tumours of cutaneous or mucosal epithelia, called papillomas or warts.
  • Cattle papillomas are benign tumours and generally regress without eliciting any serious clinical problems in the host, but occasionally persist and provide the focus for malignant transformation to squamous cell carcinoma, as in the case of cancer of the urinary bladder and cancer of the upper alimentary canal.
  • These tumours are the most common dermatological tumour of equids worldwide.
  • The purpose of this review is to discuss the biology of BPV, the biology of bovine tumours and equine sarcoids, and present the current understanding of BPV in tumour pathogenesis in its natural host, cattle, and in its heterologous host, equids.

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  • (PMID = 18927950.001).
  • [ISSN] 1365-3164
  • [Journal-full-title] Veterinary dermatology
  • [ISO-abbreviation] Vet. Dermatol.
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / / ; United Kingdom / Medical Research Council / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 140
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20. Schmidt JM, North SM, Freeman KP, Ramiro-Ibañez F: Feline paediatric oncology: retrospective assessment of 233 tumours from cats up to one year (1993 to 2008). J Small Anim Pract; 2010 Jun;51(6):306-11
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  • OBJECTIVES: To determine which types of tumour occur in cats up to the age of 12 months based on biopsies submitted to Idexx Laboratories, Wetherby, UK.
  • Tumours were categorised as haematopoietic (n=73, 31%), malignant epithelial (n=44; 19%), malignant mesenchymal (n=38; 16%), benign epithelial (n=37; 16%), benign mesenchymal (n=30, 13%) and miscellaneous (n=11; 5%).
  • The most frequent tumours were lymphoma (n=51; 22%), soft-tissue sarcoma (n=34; 15%), mast cell tumour (n=22; 9%) and squamous cell carcinoma (n=16; 7%).
  • The most common tumour site was the skin and soft tissues (41% of tumours).

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  • (PMID = 20492453.001).
  • [ISSN] 1748-5827
  • [Journal-full-title] The Journal of small animal practice
  • [ISO-abbreviation] J Small Anim Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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21. Heal C, Buettner P, Raasch B, Browning S: Minor skin excisions in general practice in North Queensland. Aust Fam Physician; 2006 Oct;35(10):825-8
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  • We excised more squamous cell carcinomas than basal cell carcinomas (0.74:1).
  • Our number needed to treat (benign or dysplastic naevi excised per melanoma) was 8.4.
  • Mean age for excision of melanoma, basal cell carcinoma and squamous cell carcinoma was 55, 60.9 and 63.8 years respectively.
  • Relative tumour density was greatest in the face, scalp and neck region for all skin cancers.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Family Practice. Skin Neoplasms / surgery

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  • (PMID = 17019461.001).
  • [ISSN] 0300-8495
  • [Journal-full-title] Australian family physician
  • [ISO-abbreviation] Aust Fam Physician
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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22. Cathenis K, Hamerlijnck R, Vermassen F, Van Nooten G, Muysoms F: Concomitant cardiac surgery and pulmonary resection. Acta Chir Belg; 2009 May-Jun;109(3):306-11
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  • Histology of the pulmonary lesion was squamous cell carcinoma in 14 patients (52%), adenocarcinoma in 10 (37%), large cell neuroendocrine tumour in 1 (3%) and typical carcinoid in 1 (3%).
  • A benign lesion was found in 1 patient (3%).


23. Alrubaiy L, Ahmed W, Sutton J: Benign endoscopic biopsies may be a red herring. BMJ Case Rep; 2009;2009
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  • [Title] Benign endoscopic biopsies may be a red herring.
  • Repeated endoscopies showed extensive candidiasis with an exophytic mass like a shelf of tumour.
  • Biopsies failed to show any neoplasm.
  • The resected mass was sent for histopathology which showed a well differentiated squamous cell carcinoma of the oesophagus which locally invaded the lung.

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  • (PMID = 21686577.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3030219
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24. Kross KW, Heimdal JH, Olsnes C, Olofsson J, Aarstad HJ: Co-culture of head and neck squamous cell carcinoma spheroids with autologous monocytes predicts prognosis. Scand J Immunol; 2008 Apr;67(4):392-9
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  • [Title] Co-culture of head and neck squamous cell carcinoma spheroids with autologous monocytes predicts prognosis.
  • Co-culture of monocytes with autologous fragment (F) spheroids originating from malignant (M) tumour or benign (B) control mucosa of head and neck squamous cell carcinoma (HNSCC) yields interleukin (IL)-6 and monocyte chemo-attractant protein (MCP)-1 secretion.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / immunology. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / immunology. Monocytes / immunology
  • [MeSH-minor] Biomarkers / metabolism. Chemokine CCL2 / metabolism. Coculture Techniques. Humans. Interleukin-6 / metabolism. Prognosis. Recurrence. Spheroids, Cellular. Tumor Cells, Cultured


25. Rafindadi AH, Samaila MO: Histopathologic analysis of epidermal skin tumours and tumour-like lesions in Ahmadu Bello University Teaching Hospital, Zaria. Niger Postgrad Med J; 2006 Dec;13(4):354-6
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  • [Title] Histopathologic analysis of epidermal skin tumours and tumour-like lesions in Ahmadu Bello University Teaching Hospital, Zaria.
  • OBJECTIVE: A histopathologic analysis of epidermal skin tumours and tumour-like lesions seen between 1991 - 2000 in the Department of Pathology, Ahmadu Bello University Teaching Hospital [A.B.U.T.H], Zaria is presented.
  • Malignant tumours constituted 72.5%; benign tumours 18.3% and tumour-like lesions 9.2%.
  • The commonest malignant lesion was squamous cell carcinoma, which constituted 68.3% of all the lesions with a male to female ratio of 1.7:1.
  • CONCLUSION: It is concluded that epidermal tumours and tumour-like lesions are not uncommon in Zaria and they show a male preponderance with squamous cell carcinoma being the commonest epidermal tumour and it also predominantly affects males.
  • [MeSH-minor] Age Distribution. Carcinoma, Basal Cell / epidemiology. Carcinoma, Squamous Cell / epidemiology. Epidermal Cyst / epidemiology. Female. Hospitals, Teaching. Humans. Keratoacanthoma / epidemiology. Keratosis, Seborrheic / epidemiology. Male. Nigeria / epidemiology. Retrospective Studies

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  • (PMID = 17203131.001).
  • [ISSN] 1117-1936
  • [Journal-full-title] The Nigerian postgraduate medical journal
  • [ISO-abbreviation] Niger Postgrad Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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26. Thomsen JB, Sørensen JA, Krogdahl A: Sentinel lymph nodes in cancer of the oral cavity -- isolated tumour cells. J Oral Pathol Med; 2005 Feb;34(2):65-9
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  • [Title] Sentinel lymph nodes in cancer of the oral cavity -- isolated tumour cells.
  • BACKGROUND: Sentinel lymph node biopsy, step sectioning and immunohistochemistry have changed detection of tumour deposits.
  • Isolated tumour cells (ITC) are detected more frequently than earlier because of a changed level of detection.
  • Benign inclusions and dendritic cells did not cause problems, but can mimic ITC.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Mouth Neoplasms / pathology. Sentinel Lymph Node Biopsy

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  • (PMID = 15641984.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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27. den Bakker MA, Ansink AC, Ewing-Graham PC: "Cutaneous-type" angiosarcoma arising in a mature cystic teratoma of the ovary. J Clin Pathol; 2006 Jun;59(6):658-60
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  • Benign and malignant somatic tumours arising in mature cystic teratomas of the ovary are a rare but recognised phenomenon.
  • Squamous cell carcinoma is the most common somatic malignancy arising in ovarian teratomas, although many other types of tumour have been described.

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  • (PMID = 16731607.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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28. Meer S, Altini M: CK7+/CK20- immunoexpression profile is typical of salivary gland neoplasia. Histopathology; 2007 Jul;51(1):26-32
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  • The tumours included pleomorphic adenoma (n = 24), myoepithelioma (n = 9), papillary cystadenoma (n = 3), oncocytoma (n = 2), adenoid cystic carcinoma (n = 22), mucoepidermoid carcinoma (n = 21), polymorphous low-grade adenocarcinoma (n = 21), carcinoma ex-pleomorphic adenoma (n = 11), acinic cell carcinoma (n = 17), epimyoepithelial carcinoma (n = 7), oncocytic carcinoma (n = 3), hyalinizing clear cell carcinoma (n = 1), papillary cystadenocarcinoma (n = 1), salivary duct carcinoma (n = 3), adenocarcinoma (not otherwise specified) (n = 4) and squamous carcinoma (n = 4).
  • The results were expressed semiquantitatively, according to the estimated percentage of positive tumour cells: 1+, 5-25%; 2+, 26-75%; and 3+, 76-100%.
  • Squamous carcinoma showed negative CK7/20 immunoexpression.
  • CONCLUSIONS: Although the CK7/20 immunoprofile is not useful in distinguishing the various types of salivary gland neoplasms or between benign and malignant salivary gland tumours, it may facilitate differentiation of primary salivary gland neoplasia from metastatic tumours and squamous carcinoma, and the diagnosis of metastatic salivary gland tumours.
  • [MeSH-minor] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / metabolism. Adenoma, Pleomorphic / pathology. Carcinoma, Acinar Cell / diagnosis. Carcinoma, Acinar Cell / metabolism. Carcinoma, Acinar Cell / pathology. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / metabolism. Carcinoma, Mucoepidermoid / pathology. Diagnosis, Differential. Gene Expression Regulation, Neoplastic. Humans. Salivary Glands / metabolism. Salivary Glands / pathology

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  • (PMID = 17593078.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Keratin-20; 0 / Keratin-7
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29. Linecker A, Kermer C, Sulzbacher I, Angelberger P, Kletter K, Dudczak R, Ewers R, Becherer A: Uptake of (18)F-FLT and (18)F-FDG in primary head and neck cancer correlates with survival. Nuklearmedizin; 2008;47(2):80-5; quiz N12
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  • Tumour tracer uptake was determined by standardized uptake value (SUV) normalized to body weight and /non-tumor ratios (T/N). (18)F-FDG and (18)F-FLT uptake were compared with histopathologic and immunohistochemical results.
  • RESULTS: 19 patients had malignant tumours; one patient had a benign cystadenoma (so called Warthin's tumour) of the parotid gland.
  • One negative lesion turned out to be a malignant T1 stage squamous cell carcinoma in both PET scans, the Warthin's tumour was false positive with (18)F-FDG but showed only faint uptake with (18)F-FLT, resulting in a sensitivity of 95 % for both tracers.

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  • (PMID = 18392317.001).
  • [ISSN] 0029-5566
  • [Journal-full-title] Nuklearmedizin. Nuclear medicine
  • [ISO-abbreviation] Nuklearmedizin
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Dideoxynucleosides; 0 / Fluorine Radioisotopes; 0 / Radioisotopes; 0Z5B2CJX4D / Fluorodeoxyglucose F18; PG53R0DWDQ / alovudine
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30. Hafidh MA, Lacy PD, Hughes JP, Duffy G, Timon CV: Evaluation of the impact of addition of PET to CT and MR scanning in the staging of patients with head and neck carcinomas. Eur Arch Otorhinolaryngol; 2006 Sep;263(9):853-9
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  • The addition of whole body positron emission tomography (PET) to the investigation of patients with newly diagnosed head and neck squamous cell carcinoma (HNSCC) was assessed over a 6-month period.
  • SUV levels above 5 were considered indicative of the presence of tumour, values below 3 indicative of benign aetiology and values equal to and between 3 and 5 were considered equivocal.
  • None of the three imaging modalities was able to identify the tumour site in the three patients with unknown primaries.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Head and Neck Neoplasms / pathology. Magnetic Resonance Imaging / methods. Positron-Emission Tomography / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prospective Studies. ROC Curve. Sensitivity and Specificity

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  • (PMID = 16724209.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
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31. Setoyama T, Natsugoe S, Okumura H, Matsumoto M, Uchikado Y, Aikou T: Isolated tumour cells in blood and E-cadherin expression in oesophageal squamous cell cancer. Br J Surg; 2007 Aug;94(8):984-91
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  • [Title] Isolated tumour cells in blood and E-cadherin expression in oesophageal squamous cell cancer.
  • BACKGROUND: Patients with oesophageal squamous cell carcinoma have a high rate of recurrence, even after curative resection.
  • The aim of this study was to examine the correlation between the presence of isolated tumour cells (ITCs) in the blood and recurrence, and between the presence of ITCs and E-cadherin expression in the primary tumour in these patients.
  • METHODS: Blood samples obtained immediately before and after resection in 125 patients with oesophageal squamous cell carcinoma were examined by real-time reverse transcription-polymerase chain reaction using carcinoembryonic antigen mRNA.
  • Blood samples from 28 healthy volunteers and 42 patients with benign diseases were used as controls.
  • ITC positivity correlated significantly with tumour depth, lymph node metastasis, stage, lymphatic invasion and venous invasion.
  • Multivariable analysis revealed that tumour depth and ITC positivity were independent factors for a shortened haematogenous disease-free interval.
  • A significant correlation was found between ITC positivity and reduced E-cadherin expression in the primary tumour (P < 0.001).
  • CONCLUSION: Examination of ITCs in the blood is useful for predicting haematogenous recurrence in patients with oesophageal squamous cell carcinoma.
  • [MeSH-major] Cadherins / metabolism. Carcinoma, Squamous Cell / surgery. Esophageal Neoplasms / surgery. Neoplastic Cells, Circulating
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoembryonic Antigen / metabolism. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Survival Analysis. Tumor Cells, Cultured

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  • [Copyright] Copyright (c) 2007 British Journal of Surgery Society Ltd.
  • (PMID = 17410638.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cadherins; 0 / Carcinoembryonic Antigen; 0 / RNA, Messenger
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32. Driemel O, Dahse R, Berndt A, Pistner H, Hakim SG, Zardi L, Reichert TE, Kosmehl H: High-molecular tenascin-C as an indicator of atypical cells in oral brush biopsies. Clin Oral Investig; 2007 Mar;11(1):93-9
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  • Tumour-invasion like wound healing is characterised by the formation of an extracellular matrix with a high tenascin-C content.
  • Analysis using antibody BC2 indicates that especially the high-molecular tenascin-C (hm tn-C) variants are typically tumour-associated, while distribution in normal tissue is restrictive.
  • Conventional cytology produced four false-positives when identifying atypical cells in brush biopsies of inflammatory/benign hyperproliferative mucosa (specificity 96%), while 10 in 52 carcinomas and three of eight recurrences were not identified (sensitivity 78%).
  • [MeSH-major] Biomarkers, Tumor / analysis. Biopsy / methods. Carcinoma, Squamous Cell / pathology. Mouth Neoplasms / pathology. Tenascin / analysis
  • [MeSH-minor] Epithelial Cells / pathology. Humans. Immunoenzyme Techniques. Mouth Mucosa / pathology. Neoplasm Invasiveness / pathology. Prospective Studies. Sensitivity and Specificity

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  • (PMID = 17111122.001).
  • [ISSN] 1432-6981
  • [Journal-full-title] Clinical oral investigations
  • [ISO-abbreviation] Clin Oral Investig
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tenascin
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33. Glynn F, Keogh IJ, Ali TA, Timon CI, Donnelly M: Routine nasopharyngeal biopsy in adults presenting with isolated serous otitis media: is it justified? J Laryngol Otol; 2006 Jun;120(6):439-41
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  • The four patients with suspicious-looking masses were all found to have malignancies (two squamous cell carcinomas, one B-cell non-Hodgkin lymphoma and one adenocarcinoma).
  • All other patients with masses were found to have benign lymphoid hyperplasia.
  • We would advocate a high index of suspicion of a nasopharyngeal tumour in adults presenting with SOM.

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  • (PMID = 16772052.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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34. Lauwers P, Hendriks J, Van Schil P: Lobectomy of the right lower lobe for lung cancer. Multimed Man Cardiothorac Surg; 2005 Jan 1;2005(628):mmcts.2004.000059
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  • Lobectomy is the treatment of choice for primary non-small cell lung cancer (NSCLC), provided that the patient is fit enough to undergo surgery, the primary tumour is confined to one lobe and there are no distant metastases.
  • Other indications for lobectomy include metastatic disease (with multiple nodules in one lobe or central localisation of metastasis), centrally located benign tumours (such as hamartoma), extensive infectious diseases (such as lung abcess, bronchiectasis), and congenital anomalies (such as congenital cystic adenomatoid malformation-CCAM).
  • A lobectomy of the right lower lobe for squamous cell carcinoma is presented in a 66-year old patient.

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  • (PMID = 24414724.001).
  • [Journal-full-title] Multimedia manual of cardiothoracic surgery : MMCTS
  • [ISO-abbreviation] Multimed Man Cardiothorac Surg
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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35. Woenckhaus M, Klein-Hitpass L, Grepmeier U, Merk J, Pfeifer M, Wild P, Bettstetter M, Wuensch P, Blaszyk H, Hartmann A, Hofstaedter F, Dietmaier W: Smoking and cancer-related gene expression in bronchial epithelium and non-small-cell lung cancers. J Pathol; 2006 Oct;210(2):192-204
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  • [Title] Smoking and cancer-related gene expression in bronchial epithelium and non-small-cell lung cancers.
  • Gene expression in surgically resected and microdissected samples of non-small-cell lung cancers (18 squamous cell carcinomas and nine adenocarcinomas), matched normal bronchial epithelium, and peripheral lung tissue from both smokers (n = 22) and non-smokers (n = 5) was studied using the Affymetrix U133A array.
  • Hierarchical cluster analysis clearly distinguished between benign and malignant tissue and between squamous cell carcinomas and adenocarcinomas.
  • One gene is a tumour suppressor gene (HLF); two genes act as oncogenes (FGFR3 and LMO3); two genes are involved in matrix degradation (MMP12 and PTHLH); three genes are related to cell differentiation (SPRR1B, RTN1, and MUC7); and five genes have not been well characterized to date.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / genetics. Lung Neoplasms / genetics. Smoking / adverse effects
  • [MeSH-minor] Adenocarcinoma / etiology. Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adult. Aged. Bronchi / metabolism. Carcinoma, Squamous Cell / etiology. Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / pathology. Cluster Analysis. Female. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Neoplasm Proteins / metabolism. Neoplasm Staging. Oligonucleotide Array Sequence Analysis / methods. Pulmonary Alveoli / metabolism. Reverse Transcriptase Polymerase Chain Reaction / methods


36. Panchal L, Vaideeswar P, Kathpal D, Madiwale CV, Prabhat DP: Sino-nasal epithelial tumours: a pathological study of 69 cases. J Postgrad Med; 2005 Jan-Mar;51(1):30-4; discussion 34-5
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  • The tumours were classified as benign or malignant.
  • Twenty were benign and 49 malignant; occurring predominantly in males.
  • Benign lesions included four squamous papillomas and 16 inverted papillomas, with recurrence in three inverted papillomas (21%).
  • Squamous cell carcinomas were the commonest among malignant tumours and four of these were associated with inverted or cylindrical cell papilloma.
  • The second most frequent malignant tumour was adenoid cystic carcinoma with eight cases.
  • Other rare types included the variants of squamous carcinoma, adenocarcinomas of the non-enteric type, muco-epidermoid carcinoma and undifferentiated carcinomas.
  • Inverted papillomas and squamous cell carcinomas are the most frequent neoplasms.

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  • (PMID = 15793335.001).
  • [ISSN] 0022-3859
  • [Journal-full-title] Journal of postgraduate medicine
  • [ISO-abbreviation] J Postgrad Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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37. Pavićević R, Bubanović G, Franjević A, Stancić-Rokotov D, Samarzija M: CYFRA 21-1 in non-small cell lung cancer--standardisation and application during diagnosis. Coll Antropol; 2008 Jun;32(2):485-98
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  • [Title] CYFRA 21-1 in non-small cell lung cancer--standardisation and application during diagnosis.
  • There is no ideal tumour marker at present.
  • Standardisation is achieved by determining the reference range in asymptomatic population, benign and malignant lung diseases, and benign and malignant diseases of other organs.
  • The cut-off level of CYFRA 21-1 for non-small cell lung cancer (NSCLC) is 1.72 ng/mL in the Croatian population.
  • It is based on the clinically applicable sensitivity of 78% and specificity of 95% in benign lung diseases.
  • For clinicians the level of CYFRA 21-1 is an early sign of NSCLC in relation to all the benign lung diseases and all the benign diseases of other organs, of which it was confirmed that they can influence the above level, provided that NSCLC is verified using standard diagnostic methods.
  • This research has involved 343 healthy persons, 474 patients with a benign disease and 4440 patients with a malignant disease, 2453 of whom suffer from NSCLC.
  • The sensitivity of CYFRA 21-1 in NSCLC is 78%, in squamous cell lung cancer (SQC) 84.6%, in adenocarcinomas (AD) 74.3% and in large cell lung cancer (LCC) 75.3%.
  • The level of CYFRA 21-1 differs significantly between healthy persons, benign and malignant diseases (p<10(-3)).
  • [MeSH-major] Antigens, Neoplasm / blood. Biomarkers, Tumor / blood. Carcinoma, Non-Small-Cell Lung / diagnosis. Keratins / blood. Lung Neoplasms / diagnosis

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  • (PMID = 18756899.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Croatia
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Keratin-19; 0 / antigen CYFRA21.1; 68238-35-7 / Keratins
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38. Kohrenhagen N, Voelker HU, Kapp M, Dietl J, Kämmerer U: The expression of galectin-1 in vulvar neoplasia. Anticancer Res; 2010 May;30(5):1547-52
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  • Galectin-1, a member of an ubiquitous expressed beta-galactoside-binding family that comprises over 140 members to date, has been shown to be involved in many physiological and pathological processes, such as tumour progression, by promoting cancer cell invasion and metastasis, in apoptosis, embryogenesis and immunobiology.
  • As the result of these findings, galectin-1 has been described as a potential marker for tumour progression in some malignancies.
  • In this study, the expression pattern of galectin-1 was determined in 73 formalin-fixed, paraffin-embedded vulvar tissues by a standard immunohistochemical method: 12 benign vulvar specimen, 41 vulvar intraepithelial lesions (VIN), according to their differentiation were subdivided into VIN I, II and III and 20 invasive squamous cell carcinomas (ISCC).
  • The immunohistochemical analyses showed that the intensity of galectin-1 expression on stromal cells next to the neoplastic cells steadily increased according to the pathological grade: benign vulvar tissue <VIN I<VIN II<VIN II<VIN III<ISCC (p<0.0001).
  • [MeSH-minor] Apoptosis. Carcinoma, Squamous Cell / metabolism. Disease Progression. Female. Humans. Immune System. Immunohistochemistry / methods. Neoplasm Invasiveness. Neoplasm Metastasis. Vulva / metabolism

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  • (PMID = 20592339.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Galectin 1
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39. Morgan JL, Khan HN, Lambertz MM: Oesophageal stenting in a district general hospital. Surgeon; 2009 Aug;7(4):203-5
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  • Most common causes were advanced adenocarcinoma (34; 60%) and squamous cell carcinoma (16; 28%).
  • Other rarer causes were benign stricture of the oesophagus, lung carcinoma, non-Hodgkin's lymphoma and salivary gland tumour.

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  • (PMID = 19736885.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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40. Li Q, Gao C, Juzi JT, Hao X: Analysis of 82 cases of retroperitoneal schwannoma. ANZ J Surg; 2007 Apr;77(4):237-40
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  • Two patients (2.4%) had multiple schwannomas and two others had a simultaneous malignancy (adenocarcinoma of the ascending colon and squamous-cell carcinoma of the lung, respectively).
  • Pathological results showed 81 (98.8%) were benign schwannoma and 1 (1.2%) was a malignant one.
  • The tumour size ranged from 3 to 22 cm.
  • One benign schwannoma recurred 3 years after the operation.
  • CONCLUSION: Most of the retroperitoneal schwannomas are benign.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Diagnostic Imaging. Female. Humans. Infant. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 17388825.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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41. Chakraborty S, Swanson BJ, Bonthu N, Batra SK: Aberrant upregulation of MUC4 mucin expression in cutaneous condyloma acuminatum and squamous cell carcinoma suggests a potential role in the diagnosis and therapy of skin diseases. J Clin Pathol; 2010 Jul;63(7):579-84
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  • [Title] Aberrant upregulation of MUC4 mucin expression in cutaneous condyloma acuminatum and squamous cell carcinoma suggests a potential role in the diagnosis and therapy of skin diseases.
  • METHODS: A total of 330 tissue spots representing the normal skin, and benign and malignant cutaneous diseases, were analysed after staining with the monoclonal antibody to human MUC4 (clone 8G7).
  • RESULTS: While the normal epidermis showed a negative to weak-positive expression of MUC4, its expression was significantly upregulated in squamous cell carcinomas (SCCs) where the intensity of staining correlated negatively with tumour grade and positively with age.
  • Malignant melanoma, basal cell carcinoma and cutaneous cysts were negative.

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  • [Cites] J Am Acad Dermatol. 2000 Jan;42(1 Pt 2):4-7 [10607349.001]
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  • (PMID = 20591909.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA078590-13; United States / NCI NIH HHS / CA / U01 CA111294; United States / NCI NIH HHS / CA / R01 CA78590; United States / NCI NIH HHS / CA / P50 CA127297; United States / NCI NIH HHS / CA / R01 CA078590; United States / NCI NIH HHS / CA / R01 CA131944; United States / NCI NIH HHS / CA / R01 CA 133774; United States / NCI NIH HHS / CA / R01 CA133774
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MUC4 protein, human; 0 / Mucin-4; 0 / Neoplasm Proteins
  • [Other-IDs] NLM/ NIHMS224552; NLM/ PMC2920126
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42. Münz M, Zeidler R, Gires O: The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABP. Cancer Lett; 2005 Jul 8;225(1):151-7
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  • [Title] The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABP.
  • The epithelial cell adhesion molecule, EpCAM, is a transmembrane glycoprotein associated with both benign and malignant proliferation.
  • In cancer cells, expression levels of this tumour-associated antigen correlate positively with the grade of dysplasia and are also a negative prognostic factor for breast cancer patients.
  • De novo expression of EpCAM resulted in the rapid upregulation of the proto-oncogene c-Myc along with enhanced cell proliferation and metabolism.
  • Additionally, E-FABP levels correlated with the amount of EpCAM in permanent squamous cell carcinoma lines and in vivo in primary head and neck carcinomas.
  • Taken together, these results provide further evidence for the direct involvement of EpCAM in signalling processes, gene regulation, and cellular metabolism supporting its important role in tumour biology.
  • [MeSH-major] Antigens, Neoplasm / physiology. Carcinoma, Squamous Cell / genetics. Cell Adhesion Molecules / physiology. Gene Expression Regulation, Neoplastic
  • [MeSH-minor] Antigens, Differentiation. Carrier Proteins. Cell Proliferation. Epithelial Cells. Fatty Acid-Binding Proteins. Fatty Acids. Genes, myc. Humans. Proteome. Signal Transduction. Tumor Cells, Cultured. Up-Regulation

  • Gene Ontology. gene/protein/disease-specific - Gene Ontology annotations from this paper .
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  • (PMID = 15922867.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antigens, Differentiation; 0 / Antigens, Neoplasm; 0 / Carrier Proteins; 0 / Cell Adhesion Molecules; 0 / EPCAM protein, human; 0 / FABP5 protein, human; 0 / Fatty Acid-Binding Proteins; 0 / Fatty Acids; 0 / Proteome
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43. Abu-Eid R, Landini G: Morphometrical differences between pseudo-epitheliomatous hyperplasia in granular cell tumours and squamous cell carcinomas. Histopathology; 2006 Mar;48(4):407-16
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  • [Title] Morphometrical differences between pseudo-epitheliomatous hyperplasia in granular cell tumours and squamous cell carcinomas.
  • AIM: Granular cell tumour (GCT) is a benign tumour which occasionally induces pseudo-epitheliomatous hyperplasia (PEH) of the covering epithelium, mimicking squamous cell carcinoma (SCC) invasion.
  • The cell-wise discrimination between the two entities using cellular morphology was 76% but when the two approaches were combined, the correct discrimination was 96%.
  • Characterization of these differences may help to elucidate some of the mechanisms of tumour infiltration and metastasis.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Granular Cell Tumor / pathology. Mouth Neoplasms / pathology

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  • (PMID = 16487362.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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44. Li X, Qiao Z, Long X, Wei J, Cheng Y: Serum concentration of AMDL DR-70 for the diagnosis and prognosis of carcinoma of the tongue. Br J Oral Maxillofac Surg; 2005 Dec;43(6):513-5
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  • The aim of this study was to discover the clinical value of the tumour marker AMDL DR-70 in a group of patients with cancer of the tongue.
  • Serum concentrations of AMDL DR-70 were estimated by enzyme linked immuno-sorbent assay in 52 patients with carcinoma of the tongue and compared with 40 controls and 42 patients with benign lesions in the tongue.
  • Thirty-nine patients with carcinoma of the tongue had results above 6 mg/L (75%), compared with 3/40 (7%) in healthy controls and 4/42 (10%) in those with benign tumours.
  • [MeSH-major] Biomarkers, Tumor / analysis. Biomarkers, Tumor / blood. Carcinoma, Squamous Cell / diagnosis. Fibrin Fibrinogen Degradation Products / analysis. Fibrinogen / analysis. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Female. Fibroma / blood. Follow-Up Studies. Hemangioma / blood. Humans. Male. Middle Aged. Neoplasm Staging. Neurofibroma / blood. Prognosis. Reagent Kits, Diagnostic. Sensitivity and Specificity. Survival Rate

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  • (PMID = 16188352.001).
  • [ISSN] 0266-4356
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Fibrin Fibrinogen Degradation Products; 0 / Reagent Kits, Diagnostic; 9001-32-5 / Fibrinogen
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45. Biswas D, Crank S: Aetiopathology of maxillary swelling--a 3-year prospective study. Eur Arch Otorhinolaryngol; 2007 Nov;264(11):1295-9
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  • A wide variety of lesions and not necessarily a malignant tumour can cause maxillary swelling.
  • Maxillary swelling was found to be caused by malignant tumours in 54.2%, benign neoplasms in 22.9% and non-neoplastic lesions in 22.9%.
  • Overall squamous cell carcinoma (22.9%) was the commonest lesion, tumour of vascular origin was the commonest benign neoplasm and odontogenic cyst was the commonest among the non-neoplastic lesions.

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  • (PMID = 17611767.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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46. Martín-Ezquerra G, Salgado R, Toll A, Gilaberte M, Baró T, Alameda Quitllet F, Yébenes M, Solé F, Garcia-Muret M, Espinet B, Pujol RM: Multiple genetic copy number alterations in oral squamous cell carcinoma: study of MYC, TP53, CCDN1, EGFR and ERBB2 status in primary and metastatic tumours. Br J Dermatol; 2010 Nov;163(5):1028-35
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  • [Title] Multiple genetic copy number alterations in oral squamous cell carcinoma: study of MYC, TP53, CCDN1, EGFR and ERBB2 status in primary and metastatic tumours.
  • In oral squamous cell carcinoma (OSCC) multiple cytogenetic abnormalities have been reported, but their practical significance remains uncertain.
  • The genetic and protein status of the CCND1, MYC, EGFR, ERBB2 oncogenes and the TP53 tumour suppressor gene were assessed by fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC).
  • Overexpression of p53, Myc, Cyclin D1, c-erbB-2 and epidermal growth factor receptor (EGFR) was more prevalent in malignant samples than benign samples (P < 0·05).
  • Evaluation of the genetic status of TP53, MYC, CCND1, ERBB2 and EGFR may be an additional diagnostic tool in distinguishing benign from malignant oral lesions in histopathologically challenging cases.
  • [MeSH-major] Carcinoma, Squamous Cell / genetics. Gene Dosage. Mouth Neoplasms / genetics. Oncogenes / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Biopsy. Cyclin D1 / genetics. Cyclin D1 / metabolism. Female. Genes, p53 / genetics. Humans. Lymph Nodes. Male. Middle Aged. Neoplasm Metastasis / genetics. Proto-Oncogene Proteins c-myc / genetics. Proto-Oncogene Proteins c-myc / metabolism. Receptor, Epidermal Growth Factor / genetics. Receptor, Epidermal Growth Factor / metabolism. Receptor, ErbB-2 / genetics. Receptor, ErbB-2 / metabolism


47. Ponnamperuma RM, King KE, Elsir T, Glick AB, Wahl GM, Nister M, Weinberg WC: The transcriptional regulatory function of p53 is essential for suppression of mouse skin carcinogenesis and can be dissociated from effects on TGF-beta-mediated growth regulation. J Pathol; 2009 Oct;219(2):263-74
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  • Transcriptional regulation by p53 is critical for p53-mediated tumour suppression; however, p53-mediated transactivation has been dissociated from p53-mediated biological processes including apoptosis, DNA repair, and differentiation.
  • We applied in vitro endpoints correlated with epithelial tumourigenesis and an in vivo assay of tumour phenotype to assess whether loss of p53-mediated transcriptional regulation underlies the malignant phenotype of p53(-/-)/v-ras(Ha)-overexpressing keratinocytes.
  • The p53(QS - val135) allele did not confer a dominant-negative phenotype, as p53(+/QS - val135) keratinocytes senesced normally in response to v-ras(Ha) expression and formed benign tumours.
  • Furthermore, TGF-beta enhances p53QS-induced activation of a dual p53-TGF-beta responsive reporter in a keratinocyte cell line.
  • These findings support an essential role for p53-mediated transcriptional regulation in suppressing malignancies arising from ras-induced skin tumours, consistent with previous findings in spontaneous carcinogenesis in other organs, and highlight the potential importance of senescence for tumour suppression in vivo.

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  • [Copyright] 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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  • (PMID = 19718706.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA100845; United States / NCI NIH HHS / CA / R01 CA100845-05; United States / FDA HHS / BO / Z01 BO04006-06
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Transforming Growth Factor beta; 0 / Tumor Suppressor Protein p53
  • [Other-IDs] NLM/ NIHMS146961; NLM/ PMC4208754
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48. Molina R, Auge JM, Escudero JM, Marrades R, Viñolas N, Carcereny E, Ramirez J, Filella X: Mucins CA 125, CA 19.9, CA 15.3 and TAG-72.3 as tumor markers in patients with lung cancer: comparison with CYFRA 21-1, CEA, SCC and NSE. Tumour Biol; 2008;29(6):371-80
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  • [Title] Mucins CA 125, CA 19.9, CA 15.3 and TAG-72.3 as tumor markers in patients with lung cancer: comparison with CYFRA 21-1, CEA, SCC and NSE.
  • Tumor marker serum levels were prospectively studied in 289 patients with suspected, but unconfirmed, lung cancer and in 513 patients with lung cancer [417 non-small cell lung cancer (NSCLC) patients and 96 small cell lung cancer (SCLC) patients].
  • In patients with benign disease, abnormal serum levels were found for the following tumor markers: CEA (in 6.6% of patients); CA 19.9 (6.2%); CA 125 (28.7%); NSE (0.7%); CYFRA (8.7%); TAG-72.3 (4.2%); SCC (3.5%), and CA 15.3 (3.5%).
  • Excluding patients with renal failure or liver diseases, tumor marker specificity improved with abnormal levels in 0.5% for NSE, 0.9% for SCC, 2.8% for CEA, CA 15.3 and TAG-72.3, 3.8% for CA 19.9, 4.2% for CYFRA and 21.4% for CA 125.
  • Tumor marker sensitivity was related to cancer histology and tumor extension.
  • Likewise, significantly higher CEA (p < 0.0001), TAG-72.3 (p < 0.001), CA 15.3 (p < 0.0001) and CA 125 (p < 0.01) were found in adenocarcinomas than in squamous tumors.
  • Using a combination of 3 tumor markers (CEA, CYFRA 21-1 in all histologies, SCC in squamous tumors and CA 15.3 in adenocarcinomas), a high sensitivity may be achieved in all histological types.
  • Tumor markers may be useful in the histological differentiation of NSCLC and SCLC.
  • [MeSH-major] Antigens, Neoplasm / blood. Biomarkers, Tumor / blood. Lung Neoplasms / blood

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 19060513.001).
  • [ISSN] 1423-0380
  • [Journal-full-title] Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • [ISO-abbreviation] Tumour Biol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor
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49. Kondo T, Matsuyoshi A, Matsuyoshi H, Goto R, Ono K, Honda Y, Iyama K, Tsuruzoe K, Miyamura N, Araki E: A case of primary thyroid squamous cell cancer: transformation from benign tumour associated with chronic thyroiditis? BMJ Case Rep; 2009;2009
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  • [Title] A case of primary thyroid squamous cell cancer: transformation from benign tumour associated with chronic thyroiditis?
  • Primary squamous cell cancer of the thyroid gland (SCT) is a rare malignant tumour and is associated with a high mortality.

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  • (PMID = 21686450.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3029573
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50. Parkins GE, Armah G, Ampofo P: Tumours and tumour-like lesions of the lower face at Korle Bu Teaching Hospital, Ghana--an eight year study. World J Surg Oncol; 2007;5:48
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  • [Title] Tumours and tumour-like lesions of the lower face at Korle Bu Teaching Hospital, Ghana--an eight year study.
  • RESULTS: A total of 394 patients with oro-facial swellings were retrieved from the registry out of which 210 had lower face tumour and tumour-like lesions.
  • Seventy eight (45.6%) of the patients presented with lesions that were classified as malignant of which 54 (62%) were diagnosed as squamous cell carcinoma (SCC).
  • Sixty-two (36.3%) had benign odontogenic tumours and thirty-one (18.1%) had non-odontogenic tumour-like lesions.
  • Fifty-four (62%) of malignant tumours were squamous cell carcinoma; 58 (93.6%) of the benign odontogenic tumours were classified as ameloblastoma.
  • The mean age at presentation of all lesions was 40.4 years with over 50% of benign lesions in patients aged between 11 and 30 years.
  • CONCLUSION: Tumours and tumour-like lesions of the lower face comprising the mandible, tongue and adjacent structures are a diverse group of neoplasm and are seen commonly in practice of Maxillofacial surgery.
  • Both malignant and benign tumours are seen in the Ghanaian population.
  • In the present study, SCC and ameloblastoma were the commonest malignant and benign odontogenic tumours seen respectively; the two representing more than 65% of all tumours.

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  • (PMID = 17484780.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1885260
  • [General-notes] NLM/ Original DateCompleted: 20070813
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51. Aoyagi S, Izumi K, Hata H, Kawasaki H, Shimizu H: Usefulness of real-time tissue elastography for detecting lymph-node metastases in squamous cell carcinoma. Clin Exp Dermatol; 2009 Dec;34(8):e744-7
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  • [Title] Usefulness of real-time tissue elastography for detecting lymph-node metastases in squamous cell carcinoma.
  • Histologically, the metastatic tumour cells were located asymmetrically in a small section of the cortical area of the right node, and this result was comparable with the elastographic findings.
  • It has high predictive values in the differentiation of benign and malignant superficial lymph nodes in patients with clinically node-negative skin cancer.
  • More cases are needed to validate this efficiency in differentiating benign from malignant lymph-node status, but if confirmed, it may have an important role in the diagnosis of high-risk cutaneous squamous cell carcinoma.
  • [MeSH-major] Bowen's Disease / pathology. Carcinoma, Squamous Cell / secondary. Skin Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Elasticity Imaging Techniques. Female. Humans. Lymphatic Metastasis. Neoplasm Staging


52. Jiang Y, Chen Y, Gao L, Ye Q, Alonso MA: [Expression pattern of MAL in normal epithelial cells, benign tumor, and squamous cell carcinoma of larynx]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2009 May;23(10):451-3
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  • [Title] [Expression pattern of MAL in normal epithelial cells, benign tumor, and squamous cell carcinoma of larynx].
  • METHOD: Use the immunohistochemical technique to analyze the distribution of MAL in normal laryngeal epithelial cells, polyp of vocal cords, laryngeal atypical hyperplasia and laryngeal squamous cell carcinoma.
  • Comparatively, MAL expression is significantly down regulated in laryngeal atypical hyperplasia and laryngeal squamous cell carcinomas (P < 0.05).
  • MAL, therefore, is a potential marker for early diagnosis of laryngeal squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Laryngeal Mucosa / metabolism. Laryngeal Neoplasms / metabolism. Membrane Transport Proteins / metabolism. Myelin Proteins / metabolism. Proteolipids / metabolism

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  • (PMID = 19670627.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / MAL protein, human; 0 / Membrane Transport Proteins; 0 / Myelin Proteins; 0 / Myelin and Lymphocyte-Associated Proteolipid Proteins; 0 / Proteolipids
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53. Rong BG, Chen WL, Ding YP, Xie G, Chen Y, Wang TD: [Surgical approaches to the skull base neoplasms]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2005 Apr;40(4):291-4
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  • Eleven surgical approaches including midfacial degloving, frontal coronal discission, nasal eversion, maxillary swing, partial maxillary resection, total resection of orbit, mandibular swing, combination of front, temple, preauricular, post aureum, neck, and transoral approaches were used to resect the tumor which involved fossae pterygopalatine, paranasal sinuses, nasopharynx, antero, meso and posterobasilar region, lobi frontalis and lobi temporalis of cerebrum.
  • In 29 patients with benign tumor including 11 cases of meningioma, 3 cases of chondroma, 1 case of hemangio-meningioma, 1 case of cavernous hemangioma, 2 cases of osteodysplasia fibromas, 9 cases of neurofibroma, 1 case of glomus jugular tumor, 1 case of neurilemmoma, 19 have survived over 5 years and the longest one has survived over 8 years.
  • For 50 patients with malignant tumor including 3 cases of well-differentiated squamous cell carcinoma, 17 cases of moderately differentiated squamous cell carcinoma, 11 cases of poorly differentiated squamous cell carcinoma, 1 case of undifferentiated carcinoma, 2 cases of chondrosarcoma, 5 cases of canceration of papilloma, 2 cases of adenocarcinoma, 1 case of esthesioneuroblastoma, 2 cases of malignant fibrohistiocytoma, 1 case of fibrosarcoma, 2 cases of malignant mixed tumour, 3 cases of sarcoma survival rates of 3 and 5 years were 59.2% (29/49), 38.5% (10/26) respectively.
  • CONCLUSION: In order to resect the tumor completely and reduce the complication and malformation as far as possible, different surgical approaches must be designed according to the pathological changes characters and involved area,and the surgeon should select the shortest approach, avoid to damage the important neurovascular structure, and resect the tumor through the natural anatomy space by the shelter incision.

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  • (PMID = 16008265.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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54. Płachcińska A, Mikołajczak R, Kozak J, Rzeszutek K, Kuśmierek J: Comparative analysis of 99mTc-depreotide and 99mTc-EDDA/HYNIC-TOC thorax scintigrams acquired for the purpose of differential diagnosis of solitary pulmonary nodules. Nucl Med Rev Cent East Eur; 2006;9(1):24-9
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  • BACKGROUND: Aiming at comparison of diagnostic efficacy of 2 radiopharmaceuticals: 99mTc-depreotide (Neospect, Amersham) and 99mTc-EDDA/HYNIC-Tyr3-octreotide (Tektrotyd, Polatom), in differentiation between malignant and benign etiology of solitary pulmonary nodules (SPNs), radionuclide studies with 2 radiotracers were performed in 18 patients.
  • Additionally, uptake intensity of both radiotracers in nodules was assessed semiquantitatively, using a tumour-to-background ratio.
  • Verification of scintigraphic results was based in 14 cases upon a pathological examination of tumour samples (histopathology) and in the remaining 4 - on clinical observation and bacteriological studies.
  • In 6 patients a malignant etiology--lung cancer--was revealed (5--adenocarcinoma, 1--squamous cell) and the other 12 cases turned out to be benign (4 hamartomas, 3 tuberculomas, a tuberculous infiltrate, an alien body with inflammatory reaction, a hyperplasia of lymphatic tissue and 2 cases of unknown etiology, from which one had a stable size and the other resolved during a 6 month observation period).
  • From among 12 cases of benign etiology 6 99mTc-depreotide scintigrams were true negative, 1--equivocal and 5--false positive, whereas 6 99mTc-EDDA/HYNIC-TOC scintigrams were true negative, 4--equivocal and 2 false positive.
  • Moreover, 99mTc-depreotide additionally revealed mediastinal and hilar lesions in 9 patients with benign lesions and 99mTc-EDDA/HYNIC-TOC - in 8.
  • However, mean values of tumour-to-lung-background ratio were equal for both radiotracers (2.2 in malignant and 1.4 in benign lesions, respectively).

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  • (PMID = 16791800.001).
  • [ISSN] 1506-9680
  • [Journal-full-title] Nuclear medicine review. Central & Eastern Europe
  • [ISO-abbreviation] Nucl Med Rev Cent East Eur
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Organotechnetium Compounds; 0 / Radiopharmaceuticals; 0 / technetium Tc 99m hydrazinonicotinyl-Tyr(3)-octreotide; 51110-01-1 / Somatostatin; 5657-17-0 / EDDA; 9G34HU7RV0 / Edetic Acid; 9M48M2SF02 / technetium Tc 99m depreotide; RWM8CCW8GP / Octreotide
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55. Hussein MR, Elsers DA, Fadel SA, Omar AE: Clinicopathological features of melanocytic skin lesions in Egypt. Eur J Cancer Prev; 2006 Feb;15(1):64-8
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  • The lesions examined included 12 benign naevi (BN), 10 dysplastic naevi (DN), and 21 cutaneous malignant melanomas (CMMs).
  • The mean tumour thickness (Breslow) was 6+/-0.5 mm.
  • In Egypt, CMM is the third most common cutaneous neoplasm following squamous and basal cell carcinomas.

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  • (PMID = 16374232.001).
  • [ISSN] 0959-8278
  • [Journal-full-title] European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
  • [ISO-abbreviation] Eur. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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56. Garnett MR, Puget S, Grill J, Sainte-Rose C: Craniopharyngioma. Orphanet J Rare Dis; 2007;2:18
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  • Craniopharyngiomas are benign slow growing tumours that are located within the sellar and para sellar region of the central nervous system.
  • The point prevalence of this tumour is approximately 2/100,000.
  • Craniopharyngiomas are thought to arise from epithelial remnants of the craniopharyngeal duct or Rathke's pouch (adamantinomatous type) or from metaplasia of squamous epithelial cell rests that are remnants of the part of the stomadeum that contributed to the buccal mucosa (squamous papillary type).
  • The neuroradiological diagnosis is mainly based on the three components of the tumour (cystic, solid and calcified) in the characteristic sellar/para sellar location.
  • The current treatment is gross total excision of the tumour, if there is no hypothalamic invasion or, in the presence of hypothalamic invasion, a sub-total resection with post-operative radiotherapy.

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  • (PMID = 17425791.001).
  • [ISSN] 1750-1172
  • [Journal-full-title] Orphanet journal of rare diseases
  • [ISO-abbreviation] Orphanet J Rare Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 43
  • [Other-IDs] NLM/ PMC1855047
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57. Ferri E, Iaderosa GA, Armato E: Atypical fibroxanthoma of the external ear in a cardiac transplant recipient: case report and the causal role of the immunosuppressive therapy. Auris Nasus Larynx; 2008 Jun;35(2):260-3
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  • Atypical fibroxanthoma (AF) is an unusual cutaneous fibrohistiocytic tumour that is most commonly found in ENT sun-exposed areas of elderly males.
  • Although this neoplasm is benign, it may mimic spindle cell carcinoma, squamous cell carcinoma, melanoma and soft tissue sarcoma on histologic examination.
  • We present a case of a cardiac transplant recipient who developed, after multiple cutaneous squamous tumours, an AF of external ear following the prolonged immunosuppressive treatment with cyclosporin.
  • [MeSH-major] Ear Neoplasms / pathology. Ear, External. Heart Transplantation. Histiocytoma, Benign Fibrous / pathology

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  • (PMID = 17804184.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cyclosporins; 0 / Immunosuppressive Agents
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58. Lago-Méndez L, Blanco-Carrión A, Diniz-Freitas M, Gándara-Vila P, García-García A, Gándara-Rey JM: Rhomboid glossitis in atypical location: case report and differential diagnosis. Med Oral Patol Oral Cir Bucal; 2005 Mar-Apr;10(2):123-7
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  • Median rhomboid glossitis (MRG) is an uncommon benign abnormality of the tongue, most frequently affecting men.
  • Other diagnoses considered but ruled out on the basis of the clinical and histopathological findings were haemangioma, pyogenic granuloma, amyloidosis, granular cell tumour, and squamous cell carcinoma.
  • [MeSH-minor] Amyloidosis / diagnosis. Antifungal Agents / therapeutic use. Candida albicans / isolation & purification. Candidiasis, Oral / diagnosis. Diagnosis, Differential. Granular Cell Tumor / diagnosis. Granuloma, Pyogenic / diagnosis. Hemangioma / diagnosis. Humans. Male. Middle Aged. Tongue Neoplasms / diagnosis

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  • (PMID = 15735544.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antifungal Agents
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59. Handisurya A, Rieger A, Bago-Horvath Z, Schellenbacher C, Bankier A, Salat A, Stingl G, Kirnbauer R: Rapid progression of an anal Buschke-Lowenstein tumour into a metastasising squamous cell carcinoma in an HIV-infected patient. Sex Transm Infect; 2009 Aug;85(4):261-3
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  • [Title] Rapid progression of an anal Buschke-Lowenstein tumour into a metastasising squamous cell carcinoma in an HIV-infected patient.
  • BACKGROUND: Buschke-Löwenstein tumour (BLT) of the anogenitalia is a locally invasive, destructively growing verrucous carcinoma that does not metastasise.
  • Histologically BLT resembles benign condylomata acuminata.
  • Nevertheless, the tumour grows relentlessly and may rarely progress into squamous cell cancer (SCC).
  • Six months later, the tumour had progressed into an ulcerated SCC that destroyed the rectum and perineum, with metastases to the inguinal lymph nodes.
  • Whereas highly active antiretroviral therapy (HAART) effectively suppressed HIV replication, radiochemotherapy plus anti-EGFR antibody did not halt tumour progression, and the patient died from tumour-cachexia.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma, Squamous Cell / secondary. HIV Infections / complications. Immunocompromised Host
  • [MeSH-minor] Anal Canal / pathology. Anal Canal / virology. Anti-HIV Agents / therapeutic use. Cachexia / etiology. Fatal Outcome. Groin. HIV Seropositivity / drug therapy. Humans. Lymph Nodes / pathology. Male. Middle Aged. Neoplasm Invasiveness


60. Munir N, Bradley PJ: Diagnosis and management of neoplastic lesions of the submandibular triangle. Oral Oncol; 2008 Mar;44(3):251-60
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  • Review of submandibular triangle neoplasms (benign and malignant) treated at a tertiary referral centre in the United Kingdom (1986-2004).
  • Forty nine benign and 58 malignant neoplasms of the submandibular triangle were reviewed.
  • Pleomorphic adenoma (n=37) were the most common benign neoplasms.
  • The mainstay treatment for both benign and malignant lesions was surgical either by extracapsular excision of the gland/lesion or selective levels I, IIa and III neck dissection.
  • Benign tumours manifest a mild course of disease and have an excellent prognosis following adequate excision.
  • The adequacy of primary surgery is crucial and would support the approach of a more radical excision primarily with a selective levels I, IIa and III neck dissection; ensuring a definitive operation for benign lesions, avoiding the risks of tumour spillage associated with a more limited excision; and removing the primary echelon of lymph nodes at risk of metastasis if the pathology in fact turns out to be malignant; without a significantly higher morbidity in comparison with an extracapsular gland/lesion excision.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / surgery. Child. Female. Humans. Lymphoma, Non-Hodgkin / diagnosis. Lymphoma, Non-Hodgkin / surgery. Male. Middle Aged. Retrospective Studies. Submandibular Gland Neoplasms / diagnosis. Submandibular Gland Neoplasms / surgery. Treatment Outcome

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  • (PMID = 17467329.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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61. Ge MJ, Shi D, Wu QC, Wang M, Li LB: Observation of circulating tumour cells in patients with non-small cell lung cancer by real-time fluorescent quantitative reverse transcriptase-polymerase chain reaction in peroperative period. J Cancer Res Clin Oncol; 2006 Apr;132(4):248-56
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  • [Title] Observation of circulating tumour cells in patients with non-small cell lung cancer by real-time fluorescent quantitative reverse transcriptase-polymerase chain reaction in peroperative period.
  • METHODS: Exploiting cytokeratin 19 (CK19)/carcinoembryonic antigen (CEA) mRNA as markers, 69 peripheral blood samples were collected from 23 consecutive patients with non-small cell lung cancer (NSCLC) who underwent surgical resection with curative intention in preoperative, intraoperative and postoperative period, respectively.
  • Additionally, the ten patients with benign lung disease served as control subjects undergoing surgical resection.
  • The values between adenocarcinoma and squamous carcinoma were strikingly different (4.9110+/-1.0315 vs. 4.1891+/-0.4126, t=2.364, P=0.028).
  • Surprisingly, circulating epithelial cells were detected in two patients resected for benign lung disease. (2) The CEA diagnostic test: the level of CEA mRNA ascended continuously within this period.
  • Both patients with benign lung disease served as control subjects undergoing surgical resection and the volunteers were negative.
  • CONCLUSIONS: A considerable proportion of patients who appear to have resectable NSCLC might be regarded as having systemic disease, which is often undetectable by current tumour staging method.
  • The CK19-expressing epithelial cells are released intraoperatively into the circulation, meanwhile CEA-expressing tumour cells are disseminated mostly postoperatively.
  • Surgical manipulation could promote the release of tumour cells into the bloodstream, but the ligation of pulmonary vein before the ligation of the pulmonary artery may partly prevent such release during surgery.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / pathology. Carcinoma, Non-Small-Cell Lung / surgery. Lung Neoplasms / pathology. Lung Neoplasms / surgery. Neoplastic Cells, Circulating. Reverse Transcriptase Polymerase Chain Reaction / methods

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  • (PMID = 16320073.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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62. Wenghoefer M, Pantelis A, Dommisch H, Reich R, Martini M, Allam JP, Novak N, Bergé S, Jepsen S, Winter J: Decreased gene expression of human beta-defensin-1 in the development of squamous cell carcinoma of the oral cavity. Int J Oral Maxillofac Surg; 2008 Jul;37(7):660-3
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  • [Title] Decreased gene expression of human beta-defensin-1 in the development of squamous cell carcinoma of the oral cavity.
  • The aim of this study was to investigate the gene expression of human beta-defensin-1, -2, -3 (hBD-1, -2, -3), interleukin-1beta, tumour necrosis factor-alpha and cyclooxygenase-2 in oral squamous cell carcinoma (OSCC) compared to benign and premalignant lesions as well as healthy controls.
  • RNA was extracted according to standard protocols and transcripts of hBD-1, -2, -3, interleukin-1beta, tumour necrosis factor-alpha and cyclooxygenase-2 were analysed by real-time polymerase chain reaction.
  • [MeSH-major] Anti-Infective Agents / analysis. Carcinoma, Squamous Cell / pathology. Mouth Neoplasms / pathology. beta-Defensins / analysis
  • [MeSH-minor] Cyclooxygenase 2 / analysis. Disease Progression. Fibroma / genetics. Fibroma / pathology. Gene Expression Regulation, Neoplastic / genetics. Gingiva / anatomy & histology. Humans. Interleukin-1beta / analysis. Leukoplakia, Oral / genetics. Leukoplakia, Oral / pathology. Precancerous Conditions / genetics. Precancerous Conditions / pathology. Reverse Transcriptase Polymerase Chain Reaction. Tumor Necrosis Factor-alpha / analysis

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  • (PMID = 18346877.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Anti-Infective Agents; 0 / DEFB1 protein, human; 0 / DEFB4A protein, human; 0 / Interleukin-1beta; 0 / Tumor Necrosis Factor-alpha; 0 / beta-Defensins; 0 / beta-defensin 3, human; EC 1.14.99.1 / Cyclooxygenase 2
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63. Fiorella R, Di Nicola V, Fiorella ML, Spinelli DA, Coppola F, Luperto P, Madami L: Major salivary gland diseases. Multicentre study. Acta Otorhinolaryngol Ital; 2005 Jun;25(3):182-90
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  • Benign tumours account for 80% of case histories with a relationship 1:4 M/F, the most frequent being pleomorphic adenoma (57.3% of cases), followed by Warthin's tumour (32.4%), this rating not having been confirmed in case histories (8-10%) in the literature.
  • Surgical treatment of benign tumours consisted, in 50% of cases, in superficial paroditectomy and in approximately 30% of total paroditectomy.
  • When no clinically evident lymph nodes were present (NO) considering the tumour histotype, two thirds of patients underwent surgery or radiotherapy, while in the remainder the wait-and-see attitude was prefered.
  • Oncological results obtained were compared with those reported in the literature: in fact for all benign neoplasms relapse ratings are about 5%, while for malignant tumours the worst prognosis was in squamous cell carcinoma with median of 37.7 on survival and metastasis rate of 16.5%.
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Neoplasm Staging. Otorhinolaryngologic Surgical Procedures. Surveys and Questionnaires

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  • (PMID = 16450775.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2639866
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64. Al-Shaham AA, Samher AA: Cemento-ossifying fibroma of the maxilla. J Plast Surg Hand Surg; 2010 Dec;44(6):318-21
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  • Despite the fact that cemento-ossifying fibromas of the maxilla may be quite large and locally aggressive, en-bloc excision is achieved by gentle blunt dissection, with the whole tumour mass peeled out from the adjacent structures.
  • In 1992 The World Health Organization adopted a new classification that included these fibromas as benign osseous tumours.
  • She had visual disturbances and nasal obstruction, and was treated successfully by surgical en-bloc resection of the tumour through an infraorbital transverse incision.
  • The differential diagnosis included fibrous dysplasia, osteoid osteoma, osteoblastoma, chronic sclerosing osteomyelitis, ameloblastoma, squamous cell carcinoma of the maxillary sinus, calcifying epithelial odontogenic tumour (Pindborg tumour) and calcifying odontogenic cyst (Gorlin cyst).
  • [MeSH-minor] Adult. Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Neoplasm Invasiveness / pathology. Neoplasm Staging. Risk Assessment. Surgical Procedures, Operative / methods. Time Factors. Tomography, X-Ray Computed / methods. Treatment Outcome

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  • (PMID = 21446812.001).
  • [ISSN] 2000-6764
  • [Journal-full-title] Journal of plastic surgery and hand surgery
  • [ISO-abbreviation] J Plast Surg Hand Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
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65. Acevedo-Henao CM, Talagas M, Marianowski R, Pradier O: Recurrent inverted papilloma with intracranial and temporal fossa involvement: A case report and review of the literature. Cancer Radiother; 2010 Jun;14(3):202-5
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  • Inverted papilloma (IP) is a rare nasosinusal benign tumour, with epithelium surface inversion to inside the stroma.
  • As a conclusion, inverted papilloma is a benign tumour with an aggressive course, tendency to recurrence and progression to malignancy.
  • [MeSH-minor] Carcinoma, Squamous Cell / etiology. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Combined Modality Therapy. Disease Progression. Ear, Middle / pathology. Facial Paralysis / etiology. Fatal Outcome. Hearing Loss, Conductive / etiology. Humans. Male. Middle Aged. Nasal Obstruction / etiology. Neoplasm Invasiveness / pathology. Neoplasm Recurrence, Local / surgery. Petrous Bone / pathology. Petrous Bone / surgery. Radiotherapy, Conformal. Reoperation. Temporal Lobe / pathology. Temporal Lobe / surgery

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  • [Copyright] 2010 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.
  • (PMID = 20418144.001).
  • [ISSN] 1769-6658
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 21
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66. Vandecaveye V, De Keyzer F, Hermans R: Diffusion-weighted magnetic resonance imaging in neck lymph adenopathy. Cancer Imaging; 2008;8:173-80
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  • In patients with head and neck squamous cell carcinoma (SCC), nodal metastases are an adverse prognostic factor compromising long term patient survival.
  • Next to evaluation of the primary tumour, both modalities facilitate detection of non-palpable lymph nodes (LN).
  • However, both modalities rely on size-related and morphological criteria to differentiate between benign and malignant lymph nodes, decreasing the sensitivity for detection of small metastases.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / secondary. Diffusion Magnetic Resonance Imaging / methods. Echo-Planar Imaging / methods. Head and Neck Neoplasms / diagnosis. Lymph Nodes / pathology. Lymphatic Diseases / pathology
  • [MeSH-minor] Biopsy, Needle. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Immunohistochemistry. Lymphatic Metastasis. Male. Neck / pathology. Neoplasm Staging. Postoperative Care / methods. Preoperative Care / methods. Radiotherapy, Adjuvant. Sensitivity and Specificity. Surgical Procedures, Operative / methods. Survival Rate. Treatment Outcome

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  • (PMID = 18824423.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 27
  • [Other-IDs] NLM/ PMC2556503
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67. Bugatti L, Filosa G: Dermatoscopic features of cutaneous atypical fibroxanthoma: three cases. Clin Exp Dermatol; 2009 Dec;34(8):e898-900
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  • Atypical fibroxanthoma (AFX) is an uncommon, low-grade, malignant, spindle-cell tumour of fibrohistiocytic histogenesis, which can mimic other malignant skin tumours, such as basal and squamous cell carcinoma (CC), melanoma, and Merkel cell carcinoma (MCC).
  • [MeSH-major] Dermoscopy / methods. Histiocytoma, Benign Fibrous / pathology. Melanoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 20055861.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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68. Ramani P, Thomas G, Ahmed S: Use of Rt-PCR in detecting disseminated cancer cells after incisional biopsy among oral squamous cell carcinoma patients. J Cancer Res Ther; 2005 Apr-Jun;1(2):92-7
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  • [Title] Use of Rt-PCR in detecting disseminated cancer cells after incisional biopsy among oral squamous cell carcinoma patients.
  • PURPOSE: Tumour metastasis is the most clinically significant and enigmatic aspect of tumour behavior and is an unequivocal hallmark of malignancy.
  • AIMS: This study examined whether cancer cell dissemination results from incisional biopsy in the peripheral blood by using Cytokeratin 19(CK-19) as the marker for Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR).
  • MATERIALS AND METHODS: The study population consisted of n=10 patients who were clinically diagnosed for oral squamous cell carcinoma and who had not undergone any previous biopsies.
  • 5 patients who were to undergo incisional biopsies for benign conditions served as controls.
  • [MeSH-major] Biopsy / adverse effects. Carcinoma, Squamous Cell / pathology. Keratin-19 / genetics. Mouth Neoplasms / pathology. Neoplastic Cells, Circulating. Reverse Transcriptase Polymerase Chain Reaction / methods


69. Lui PC, Tse GM, Tan PH, Jayaram G, Putti TC, Chaiwun B, Chan NH, Lau PP, Mak KL, Khin AT: Fine-needle aspiration cytology of metaplastic carcinoma of the breast. J Clin Pathol; 2007 May;60(5):529-33
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  • BACKGROUND: Metaplastic carcinoma of the breast encompasses a heterogeneous group of tumours with variable components of sarcomatoid, squamous or poorly differentiated carcinomas.
  • METHODS: 17 cases of fine-needle aspirates of histologically proven metaplastic carcinomas (4 monophasic spindle cell carcinomas, 4 squamous cell carcinomas and 11 biphasic tumours) were reviewed, with an emphasis on the presence of poorly differentiated carcinoma, squamous cell carcinoma, atypical spindle cells, benign stromal fragments and necrosis.
  • If the tumours were analysed according to the constituting components histologically, 7, 15 and 8 cases, respectively, possess poorly differentiated carcinoma cells, sarcomatoid malignant cells and squamous carcinoma cells, whereas these components were cytologically identified in 11, 10 and 7 cases, respectively.
  • Dual tumour populations were identified in only 5 of the 11 biphasic carcinomas in the cytological preparations; and the stromal material was cytologically identified in the only case with chondroid stroma.
  • The identification of dual components, unequivocal squamous carcinoma cells and chondroid stroma is helpful for diagnosis, but it is uncommon.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma / pathology. Carcinoma, Squamous Cell / pathology. Mixed Tumor, Malignant / pathology
  • [MeSH-minor] Adult. Aged. Biopsy, Fine-Needle. Cell Differentiation. Female. Humans. Metaplasia / pathology. Middle Aged. Retrospective Studies

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  • (PMID = 16798932.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1994547
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70. Sato T, Indo H, Kawabata Y, Kobayashi T, Suenaga S, Iwashita Y, Nitta T, Sugihara K, Majima HJ: Thallium-201 chloride (Tl-201) accumulation and Na+/K+-ATPase expression in tumours of the head and neck. Dentomaxillofac Radiol; 2005 Jul;34(4):212-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: The purpose of this report was to evaluate the relationship between the tumour retention index of thallium-201 chloride (Tl-201) scintigraphy and the Na+/K+-ATPase expression in tumours of the head and neck.
  • METHODS: Tl-201 scintigraphy was performed in 146 patients (129 with malignant tumours, ten with benign tumours and seven with inflammation).
  • The tumour retention index was obtained from the early and delayed dynamic Tl-201 scans.
  • The Na+/K+-ATPase expression was evaluated immunohistochemically in 61 of 129 patients with malignant tumour.
  • Furthermore, another 22 patients with benign tumour were evaluated immunohistochemically as a benign control.
  • Comparison of the correlations between the grade of histopathological differentiation of tumour, the tumour retention index of Tl-201 scintigraphy and the Na+/K+-ATPase expression was performed.
  • RESULTS: The grade of histopathological differentiation of tumour, the tumour retention index of Tl-201 scintigraphy and the expression of Na+/K+-ATPase showed a good correlation indicating that Na+/K+-ATPase plays an important role in transportation for Tl-201 to go through the tumour cell membrane.
  • CONCLUSIONS: Na+/K+-ATPase is one of the most important factors for Tl-201 accumulation in tumour.
  • [MeSH-minor] Adenocarcinoma / enzymology. Adenocarcinoma / pathology. Adenocarcinoma / radionuclide imaging. Adenolymphoma / enzymology. Adenolymphoma / pathology. Adenolymphoma / radionuclide imaging. Adenoma, Pleomorphic / enzymology. Adenoma, Pleomorphic / pathology. Adenoma, Pleomorphic / radionuclide imaging. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / enzymology. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / radionuclide imaging. Female. Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 15961594.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0 / Thallium Radioisotopes; 7791-12-0 / thallium chloride; AD84R52XLF / Thallium; EC 3.6.3.9 / Sodium-Potassium-Exchanging ATPase
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71. Righi L, Volante M, Rapa I, Scagliotti GV, Papotti M: Neuro-endocrine tumours of the lung. A review of relevant pathological and molecular data. Virchows Arch; 2007 Aug;451 Suppl 1:S51-9
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  • In the former group, a continuum of lesions is recognised ranging from benign typical carcinoids to atypical carcinoids (having a low-grade behaviour, although often associated with regional and distant metastases), to the highly aggressive poorly differentiated carcinomas of the small and large cell types.
  • In the mixed tumour group, the NE component is extensively represented in association with any of the non-small cell carcinoma subtypes (so-called combined carcinomas), or the NE component is restricted to a cell population scattered among adenocarcinoma cells (or more rarely within squamous or large cell carcinomas).
  • The molecular profile of NE tumours has been widely investigated to identify features helpful for the diagnosis, prognosis and even therapy for this special lung tumour category.
  • Specific chromosomal alterations, oncogene mutations and cell cycle molecule disregulation has been documented in NE tumours of the lung, as well as the expression of specific receptors or enzymes implicated in the response to biotherapies or to chemotherapeutic agents.

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  • (PMID = 17684766.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Number-of-references] 63
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72. Sato T, Kawabata Y, Kobayashi Y, Suenaga S, Indo H, Kawano K, Iwashita Y, Morita Y, Majima HJ: Scintigraphy for interpretation of malignant tumours of the head and neck: comparison of technetium-99m-hexakis-2-methoxyisobutylisonitrile (Tc-MIBI) and thallium-201-chloride (Tl-201). Dentomaxillofac Radiol; 2005 Sep;34(5):268-73
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  • METHODS: Dynamic and static scintigraphic imaging with 99Tc(m)-MIBI and Tl-201 were performed on patients with a variety of malignant and benign tumours.
  • Factors of the grade of the static scan, the blood flow index, the early and delayed retention indexes, and the tumour retention index were obtained from the scintigraphy.
  • In addition to these factors, the grade of tissue differentiation and tumour size were evaluated to clarify the difference between 99Tc(m)-MIBI and Tl-201 for the diagnosis of malignant tumours of the head and neck.
  • RESULTS: 99Tc(m)-MIBI accumulation depended upon the blood flow index in the early static scan, but this accumulation did not correlate with tumour size.
  • The accumulation in most subjects decreased in the delayed static scan, and the tumour retention index had a tendency to decrease with the grade of tissue differentiation.
  • Tl-201 accumulation depended upon the blood flow index in the early static scan similar to 99Tc(m)-MIBI, and the accumulation correlated with tumour size, unlike 99Tc(m)-MIBI.
  • The tumour retention index had a tendency to increase with the grade of tissue differentiation.
  • Thus, the tumour retention indexes showed opposite behaviours between 99Tc(m)-MIBI and Tl-201, but they both accurately determined tumour malignancy.
  • [MeSH-major] Carcinoma, Squamous Cell / radionuclide imaging. Head and Neck Neoplasms / radionuclide imaging. Radiopharmaceuticals. Technetium Tc 99m Sestamibi. Thallium Radioisotopes
  • [MeSH-minor] Adenocarcinoma / radionuclide imaging. Adenolymphoma / radionuclide imaging. Adenoma, Pleomorphic / radionuclide imaging. Adult. Aged. Aged, 80 and over. Cell Differentiation. Female. Humans. Male. Middle Aged. Regional Blood Flow / physiology. Retrospective Studies. Thallium. Time Factors

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  • (PMID = 16120875.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0 / Thallium Radioisotopes; 7791-12-0 / thallium chloride; 971Z4W1S09 / Technetium Tc 99m Sestamibi; AD84R52XLF / Thallium
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73. Devi PM, Singh LR, Gatphoh ED: Fibroadenoma with squamous metaplasia. Singapore Med J; 2007 Jul;48(7):682-3
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  • [Title] Fibroadenoma with squamous metaplasia.
  • Fibroadenoma is the most common benign breast tumour in adolescent and young women.
  • Squamous metaplasia in fibroadenoma is not a common finding and has not yet been reported in northeast India.
  • Squamous metaplasia in fibroadenoma probably arises from the myoepithelial cells.
  • A case of fibroadenoma with squamous metaplasia in a 20-year-old unmarried woman is reported.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Squamous Cell / pathology. Fibroadenoma / pathology

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  • (PMID = 17609833.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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74. Molina R, Augé JM, Bosch X, Escudero JM, Viñolas N, Marrades R, Ramírez J, Carcereny E, Filella X: Usefulness of serum tumor markers, including progastrin-releasing peptide, in patients with lung cancer: correlation with histology. Tumour Biol; 2009;30(3):121-9
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  • [Title] Usefulness of serum tumor markers, including progastrin-releasing peptide, in patients with lung cancer: correlation with histology.
  • BACKGROUND: Tumor markers have been extensively studied in lung cancer, reporting some relationship to the histology, but their clinical utility is not clear.
  • METHODS: ProGRP, CEA, SCC, CA 125, CYFRA 21-1 and NSE were studied prospectively in 155 patients with unconfirmed suspicion of lung cancer and in 647 patients with lung cancer: 182 squamous, 205 adenocarcinomas, 19 large-cell lung cancer (LCLC), 175 small-cell lung cancer (SCLC) and 66 unspecific non-small-cell lung cancer (NSCLC).
  • RESULTS: Abnormal tumor marker serum levels were found in less than 5.3% of the patients with benign diseases, excluding CA 125 (21.3%).
  • Tumor markers were related to histological type and tumor extension with significantly higher CEA (p <0.01) and CA 125 (p <0.007) serum levels in adenocarcinomas, SCC (p <0.0001) and CYFRA 21-1 (p <0.008) in squamous tumors and ProGRP (p <0.0001) and NSE (p <0.0001) in SCLC.
  • Tumor markers may be useful in the histological differentiation of NSCLC and SCLC.
  • CONCLUSIONS: Tumor marker determination in patients with suspicious signs of lung cancer suggests, in a few hours, the histological diagnosis in the majority of lung cancer patients.
  • [MeSH-major] Biomarkers, Tumor / blood. Carcinoma, Non-Small-Cell Lung / blood. Carcinoma, Squamous Cell / blood. Lung Neoplasms / blood. Peptide Fragments / blood. Small Cell Lung Carcinoma / blood
  • [MeSH-minor] Algorithms. Enzyme-Linked Immunosorbent Assay. Female. Humans. Male. Middle Aged. Neoplasm Staging. Recombinant Proteins / blood. Sensitivity and Specificity

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19506400.001).
  • [ISSN] 1423-0380
  • [Journal-full-title] Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • [ISO-abbreviation] Tumour Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Peptide Fragments; 0 / Recombinant Proteins; 0 / pro-gastrin-releasing peptide (31-98)
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75. Wang D, Chen S, Feng Y, Yang Q, Campbell BH, Tang X, Campbell WB: Reduced expression of 15-lipoxygenase 2 in human head and neck carcinomas. Tumour Biol; 2006;27(5):261-73
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  • In the present study, we report a significant reduction of 15-lipoxygenase 2 (15-LOX-2) in seven carcinoma cell lines of the human head and neck when compared with normal primary cultured keratinocytes, and 18 primary head and neck squamous cell carcinomas (HNSCC) when compared with matched normal mucosa.
  • 15-LOX-2 is mainly expressed in the mature cells of the benign squamous epithelium, but not in the basal layer cells of benign epithelium, suggesting a role of 15-LOX-2 in cell differentiation.
  • When the effects of NSAIDs were examined on cell proliferation and regulation of 15-LOX-2 in the carcinoma cells, NS398 treatment resulted in significant growth inhibition associated with upregulation of 15-LOX-2 and its major metabolite 15-S-HETE.
  • Finally, restoration of 15-LOX-2 expression into these carcinoma cells significantly inhibited cell proliferation.
  • [MeSH-minor] Carcinoma, Squamous Cell. Cell Proliferation. Cells, Cultured. Gene Expression Regulation, Enzymologic. Humans. Keratinocytes / enzymology. Nitrobenzenes / pharmacology. Sulfonamides / pharmacology. Tumor Cells, Cultured

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  • [Copyright] Copyright (c) 2006 S. Karger AG, Basel.
  • (PMID = 16874012.001).
  • [ISSN] 1010-4283
  • [Journal-full-title] Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • [ISO-abbreviation] Tumour Biol.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL-37981
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nitrobenzenes; 0 / Sulfonamides; 123653-11-2 / N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide; EC 1.13.11.33 / ALOX15B protein, human; EC 1.13.11.33 / Arachidonate 15-Lipoxygenase
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76. Tischoff I, Tannapfel A: [Pathologic and anatomic evidence of peritoneal metastases]. Chirurg; 2007 Dec;78(12):1085-6, 1088-90
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  • Primary tumours originating in the peritoneum such as malignant peritoneal mesothelioma, primary peritoneal carcinoma, and benign peritoneal tumours along with inflammatory and reactive lesions must be differentiated from peritoneal metastases.
  • Especially in cancer of unknown primary tumour, the discrimination between primary peritoneal tumours and peritoneal metastases is difficult and often requires immunohistochemical identification.
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Adolescent. Adult. Aged. Carcinoma / pathology. Carcinoma / secondary. Carcinoma / surgery. Carcinoma, Small Cell / pathology. Carcinoma, Small Cell / secondary. Carcinoma, Small Cell / surgery. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Cystadenocarcinoma, Mucinous / pathology. Cystadenocarcinoma, Mucinous / secondary. Cystadenocarcinoma, Mucinous / surgery. Diagnosis, Differential. Female. Humans. Male. Mesothelioma / pathology. Mesothelioma / surgery. Middle Aged. Neoplasms, Unknown Primary / pathology. Neoplasms, Unknown Primary / surgery. Ovarian Neoplasms / pathology. Ovarian Neoplasms / surgery. Peritonitis / pathology. Pseudomyxoma Peritonei / pathology. Pseudomyxoma Peritonei / surgery

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  • (PMID = 18030433.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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77. Sesterhenn AM, Mandic R, Dünne AA, Werner JA: Cytokeratins 6 and 16 are frequently expressed in head and neck squamous cell carcinoma cell lines and fresh biopsies. Anticancer Res; 2005 Jul-Aug;25(4):2675-80
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  • [Title] Cytokeratins 6 and 16 are frequently expressed in head and neck squamous cell carcinoma cell lines and fresh biopsies.
  • Recently immunohistochemical investigations demonstrated that, among others, CKs 6, 14, 16 and 17 are regularly expressed in benign stratified squamous epithelium of the head and neck as well as in squamous cell carcinoma of the head and neck (HNSCC) in contrast to CKs 1, 10 and 11, that were only rarely expressed in these tissues.
  • MATERIALS AND METHODS: Total RNA was isolated from 15 primary cell lines derived from HNSCC and from 15 tissue samples of oro- and hypopharyngeal carcinomas obtained from surgery specimens.
  • CK17 was more frequently present in tumour specimens than in HNSCC cell lines.
  • The immunohistochemical results of the surgical tumour specimens confirmed the results of Western blot analysis.
  • These results will serve as a basis for further investigations concerning the search for circulating tumour cells and micrometastases.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Head and Neck Neoplasms / metabolism. Keratins / biosynthesis
  • [MeSH-minor] Biopsy. Blotting, Western. Cell Line, Tumor. Humans. Hypopharyngeal Neoplasms / genetics. Hypopharyngeal Neoplasms / metabolism. Hypopharyngeal Neoplasms / pathology. Immunohistochemistry. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Reverse Transcriptase Polymerase Chain Reaction


78. Newton R, Ziegler J, Casabonne D, Beral V, Mbidde E, Carpenter L, Maxwell Parkin D, Wabinga H, Mbulaiteye S, Jaffe H, Uganda Kaposi's Sarcoma Study Group: A case-control study of cancer of the uterine cervix in Uganda. Eur J Cancer Prev; 2007 Dec;16(6):555-8
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  • Patients with all cancer types or with benign tumours were recruited from hospitals in Kampala, Uganda, interviewed about various demographic and lifestyle factors and tested for antibodies against the human immunodeficiency virus-1 (HIV).
  • Key findings were that the risk of cervical cancer increased linearly with the number of pregnancies [chi2(1)=44.7; P<0.0001]; a woman reporting having had 10 or more children had a roughly seven-fold increase in risk of the tumour as compared with women reporting fewer than four pregnancies (odds ratio=7.1; 95% confidence interval 3.8-13.2).
  • [MeSH-major] Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / etiology. Uterine Cervical Neoplasms / epidemiology. Uterine Cervical Neoplasms / etiology

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  • (PMID = 18090129.001).
  • [ISSN] 0959-8278
  • [Journal-full-title] European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
  • [ISO-abbreviation] Eur. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
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79. Daniels JS: Granular cell tumour of tongue: A case report. Saudi Dent J; 2009 Jul;21(2):75-8
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  • [Title] Granular cell tumour of tongue: A case report.
  • Granular cell tumour, also known as Abrikossoff tumour, is a relatively uncommon benign neoplasm, which is more commonly found in females in the 4th to 6th decades of life even though it can occur in all ages.
  • Intraoral lesions represent about 70% of the granular cell tumours of the head and neck, and account for 1/3 of all cases affecting the whole body.
  • Although majority of granular cell tumours are benign, some are clinically aggressive and a few frankly malignant forms have been reported.
  • Some benign lesions exhibit surface ulcerations and this clinical appearance, combined with the overlying pseudoepitheliomatous hyperplasia, seen histologically, may lead to misdiagnosis of malignancy if adequate biopsy material was not taken.
  • A case of granular cell tumour which occurred on the midline area of the dorsum of the posterior 1/3 of the tongue is reported in a 20-year-old female patient.
  • It is interesting because the patient was younger than the average age of occurrence and the tumour occurred in a similar site to that of a lingual thyroid.

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  • (PMID = 23960463.001).
  • [ISSN] 1013-9052
  • [Journal-full-title] The Saudi dental journal
  • [ISO-abbreviation] Saudi Dent J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Other-IDs] NLM/ PMC3722994
  • [Keywords] NOTNLM ; Dorsum of posterior one-third of tongue / Granular cell tumour / Lingual thyroid / Pseudoepitheliomatous hyperplasia / Squamous cell carcinoma of tongue
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80. Mhawech-Fauceglia P, Saxena R, Zhang S, Terracciano L, Sauter G, Chadhuri A, Herrmann FR, Penetrante R: Pax-5 immunoexpression in various types of benign and malignant tumours: a high-throughput tissue microarray analysis. J Clin Pathol; 2007 Jun;60(6):709-14
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  • [Title] Pax-5 immunoexpression in various types of benign and malignant tumours: a high-throughput tissue microarray analysis.
  • BACKGROUND: Pax-5 belongs to the Pax gene family transcription factors that play an important role in organogenesis and in B cell ontogeny.
  • It is expressed in B cell non-Hodgkin's lymphoma (B-NHL), Hodgkin's lymphoma (HL) and neuroendocrine carcinomas.
  • However, its expression in other tumour types is not fully explored.
  • AIMS AND METHODS: To determine Pax-5 expression in other tumour types, immunohistochemistry was performed on 3758 benign and malignant tumours using multiple tumour microarrays, as well as on whole sections.
  • RESULTS: Pax-5 was expressed in 108/118 (91.5%) B-NHLs, in 60/70 (85.7%) HLs and in 0/7 T cell lymphomas.
  • In addition, Pax-5 was seen in 24/34 (70.6%) Merkel cell carcinomas, 42/53 (79.2%) small cell carcinomas, 1/164 (0.6%) breast carcinomas, 2/204 (1%) endometrial adenocarcinomas and 1/452 (0.2%) urothelial carcinoma of the bladder.
  • [MeSH-major] B-Cell-Specific Activator Protein / metabolism. Biomarkers, Tumor / metabolism. Neoplasms / metabolism
  • [MeSH-minor] Carcinoma, Merkel Cell / diagnosis. Carcinoma, Merkel Cell / metabolism. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / metabolism. Diagnosis, Differential. Hodgkin Disease / diagnosis. Hodgkin Disease / metabolism. Humans. Immunoenzyme Techniques. Lung Neoplasms / diagnosis. Lung Neoplasms / metabolism. Lymphoma, Non-Hodgkin / diagnosis. Lymphoma, Non-Hodgkin / metabolism. Neoplasm Proteins / metabolism. Protein Array Analysis / methods

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  • (PMID = 16837628.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / B-Cell-Specific Activator Protein; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / PAX5 protein, human
  • [Other-IDs] NLM/ PMC1955074
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81. Behtash N, Nazari Z, Fakhrejahani F, Khafaf A, Azar EG: Clinical and histological significance of atypical glandular cell on Pap smear. Aust N Z J Obstet Gynaecol; 2007 Feb;47(1):46-9
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  • [Title] Clinical and histological significance of atypical glandular cell on Pap smear.
  • BACKGROUND: Atypical glandular cell (AGC) on Pap smear is uncommon but may represent a variety of benign and malignant lesions.
  • We found eight (19.5%) significant pathological findings including four (9.7%) high-grade squamous intraepithelial lesion, one (2.4%) adenocarcinoma of uterus, one (2.4%) adenocarcinoma of cervix, one (2.4%) squamous cell carcinoma of cervix and one (2.4%) papillary serous tumour of ovary.


82. Mukaratirwa S, Chipunza J, Chitanga S, Chimonyo M, Bhebhe E: Canine cutaneous neoplasms: prevalence and influence of age, sex and site on the presence and potential malignancy of cutaneous neoplasms in dogs from Zimbabwe. J S Afr Vet Assoc; 2005 Jun;76(2):59-62
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  • Thirty different histological types of tumour were diagnosed.
  • The 10 most common tumours, comprising 73.7% of all cutaneous neoplasms, were mast cell tumours, squamous cell carcinomas, perianal gland adenomas, lymphomas, benign melanomas, haemangiosarcomas, sebaceous gland adenomas, fibrosarcomas, lipomas and malignant melanomas.
  • The prevalence of various neoplasms, age of affected dogs and sites of occurrence were similar to surveys in other countries, except that in Zimbabwe there was a greater prevalence of lymphomas and of tumours associated with increased exposure to ultraviolet light (squamous cell carcinomas, haemangiosarcomas and melanomas).
  • For all classes of tumours the sex of the dog did not have any significant influence on the likelihood of developing a tumour.
  • For a dog diagnosed with a tumour located on the trunk, the tumour was significantly more likely to be an epithelial tumour than a non-epithelial tumour The occurrence of melanocytic tumours on the trunk was significantly lower than at other sites.

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  • (PMID = 16108522.001).
  • [ISSN] 1019-9128
  • [Journal-full-title] Journal of the South African Veterinary Association
  • [ISO-abbreviation] J S Afr Vet Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] South Africa
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83. Conscience I, Jovenin N, Coissard C, Lorenzato M, Durlach A, Grange F, Birembaut P, Clavel C, Bernard P: P16 is overexpressed in cutaneous carcinomas located on sun-exposed areas. Eur J Dermatol; 2006 Sep-Oct;16(5):518-22
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  • BACKGROUND: Recently, an increased expression of P16, a cell cycle regulatory tumor suppressor protein, has been demonstrated in cervical squamous neoplasms as a marker of malignancy.
  • OBJECTIVES: Our first aim was to evaluate P16 expression in different types of non-melanoma skin cancers compared with normal skin and benign tumors.
  • METHODS: Skin biopsy specimens with typical histologic features of squamous cell carcinoma (SCC; n = 30), Bowen's disease (BD; n = 17), basal cell carcinoma (BCC; n = 10), seborrheic keratosis (SK; n = 10) and normal human skin (NHS; n = 9) were obtained from 76 patients seen at our institution between 2001 and 2003.
  • Ki67 expression in over 5% of tumour cells was observed in 69% of cutaneous carcinomas (SCC: 54%; BD: 76%; BCC: 80%) versus 16% in the group including SK (30%) and NHS (0%) (p = 0.04).
  • Overexpression of P16 was associated with a high rate of Ki67 positive tumour cells in 23/57 malignant skin tumors (40%).

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  • (PMID = 17101472.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Ki-67 Antigen
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84. Dimba EA, Gichana J, Limo AK, Wakoli KA, Chindia ML, Awange DO: An audit of oral diseases at a Nairobi centre, 2000-2004. Int Dent J; 2007 Dec;57(6):439-44
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  • Benign tumours (mean age +/- SD = 29.93 +/- 18.27 years) peaked in the third decade and tended to affect men at a younger age (p = 0.001).
  • The most common benign tumour was the ameloblastoma (50.23%: n = 109), which predominantly affected the mandible, and also occurred in male patients at a younger age (p = 0.023).
  • Oral squamous cell carcinoma (OSCC) was the most common malignant tumour (59.55%; n = 187); occurring in the tongue, floor of the mouth, buccal mucosa and palate.
  • CONCLUSION: The tendency of oral squamous cell carcinoma to occur in younger age groups may be an indication of carcinogenic factors that could be peculiar to this population.
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Aged, 80 and over. Ameloblastoma / epidemiology. Carcinoma, Squamous Cell / epidemiology. Child. Child, Preschool. Cysts / epidemiology. Female. Humans. Hyperplasia / epidemiology. Incidence. Infant. Infant, Newborn. Kenya / epidemiology. Male. Middle Aged. Mouth Neoplasms / epidemiology. Retrospective Studies. Sex Distribution

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  • (PMID = 18265777.001).
  • [ISSN] 0020-6539
  • [Journal-full-title] International dental journal
  • [ISO-abbreviation] Int Dent J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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85. Lillo FB: Human papillomavirus infection and its role in the genesis of dysplastic and neoplastic lesions of the squamous epithelia. New Microbiol; 2005 Apr;28(2):111-8
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  • [Title] Human papillomavirus infection and its role in the genesis of dysplastic and neoplastic lesions of the squamous epithelia.
  • Extensive laboratory and epidemiological evidence demonstrate that human papillomavirus (HPV) is the major cause of squamous cervical carcinoma (SCC), its precursor lesions (cervical intraepithelial neoplasia - CIN) and several other benign and malign clinical manifestations including genital warts, condylomata acuminata, Bowenoid papulosis, vaginal, vulvar and anal intraepithelial neoplasia (VIN and AIN) and carcinoma, penile carcinoma and other squamous neoplasias of the head and neck districts.
  • The relevance and high level of scientific interest surrounding HPVs are related to the oncogenic potential of some viral types belonging to this family and the possibility to influence the incidence of various tumour forms likecervical carcinoma, improving the efficacy of specific screening programs or defining preventive strategies like vaccination.
  • [MeSH-major] Carcinoma, Squamous Cell. Cervical Intraepithelial Neoplasia. Papillomaviridae / pathogenicity. Papillomavirus Infections / virology

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  • (PMID = 16035255.001).
  • [ISSN] 1121-7138
  • [Journal-full-title] The new microbiologica
  • [ISO-abbreviation] New Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 40
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86. Roijer E, de Bruijn HW, Dahlén U, ten Hoor K, Lundin M, Nilsson K, Soderstrom K, Nilsson O: Squamous cell carcinoma antigen isoforms in serum from cervical cancer patients. Tumour Biol; 2006;27(3):142-52
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  • [Title] Squamous cell carcinoma antigen isoforms in serum from cervical cancer patients.
  • Squamous cell carcinoma antigen (SCCA) is a serological marker of squamous cell carcinomas (SCC).
  • Serum samples from patients with benign skin diseases (psoriasis and eczema) were also selected based on elevated SCCA levels.
  • SCCA2 did not show improved tumor specificity as compared to SCCA1.
  • [MeSH-major] Antigens, Neoplasm / blood. Carcinoma, Squamous Cell / diagnosis. Enzyme-Linked Immunosorbent Assay. Serpins / blood. Uterine Cervical Neoplasms / diagnosis


87. Wallowy P, Diener J, Grünwald F, Kovács AF: 18F-FDG PET for detecting metastases and synchronous primary malignancies in patients with oral and oropharyngeal cancer. Nuklearmedizin; 2009;48(5):192-9; quiz N42
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  • AIM: Assessment of the efficiency of 18F-FDG-PET (PET) for the detection of distant metastases and synchronous primary malignancies in patients with oral and oropharyngeal squamous cell cancer (OOSCC).
  • RESULTS: In 74 of 80 evaluable cases, PET showed the primary tumour (92.5%).
  • In the other 58 cases (69%), where the suspect lesions were confirmed as benign, mean SUV was 2.65 (range 0.7-6.5) (difference statistically significant).
  • [MeSH-major] Fluorodeoxyglucose F18. Mouth Neoplasms / pathology. Mouth Neoplasms / radionuclide imaging. Neoplasm Metastasis / radionuclide imaging. Oropharyngeal Neoplasms / pathology. Oropharyngeal Neoplasms / radionuclide imaging
  • [MeSH-minor] Aged. Aged, 80 and over. Humans. Middle Aged. Neoplasm Staging. Palatal Neoplasms / pathology. Palatal Neoplasms / radionuclide imaging. Positron-Emission Tomography. Retrospective Studies. Tongue Neoplasms / pathology. Tongue Neoplasms / radionuclide imaging

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  • (PMID = 19623408.001).
  • [ISSN] 0029-5566
  • [Journal-full-title] Nuklearmedizin. Nuclear medicine
  • [ISO-abbreviation] Nuklearmedizin
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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88. Das S, Kirsch CF: Imaging of lumps and bumps in the nose: a review of sinonasal tumours. Cancer Imaging; 2005;5:167-77
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  • Benign neoplasms reviewed include osteoma, inverting papilloma, and juvenile nasal angiofibroma.
  • Malignant neoplasms reviewed include squamous cell carcinoma, the minor salivary gland tumour, adenoid cystic carcinoma, adenocarcinoma, melanoma, lymphoma, and olfactory neuroblastoma (esthesioneuroblastoma).

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  • [Copyright] International Cancer Imaging Society.
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  • (PMID = 16361146.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 73
  • [Other-IDs] NLM/ PMC1665243
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89. Mhawech-Fauceglia P, Herrmann FR, Bshara W, Odunsi K, Terracciano L, Sauter G, Cheney RT, Groth J, Penetrante R, Mhawech-Fauceglia P: Friend leukaemia integration-1 expression in malignant and benign tumours: a multiple tumour tissue microarray analysis using polyclonal antibody. J Clin Pathol; 2007 Jun;60(6):694-700
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  • [Title] Friend leukaemia integration-1 expression in malignant and benign tumours: a multiple tumour tissue microarray analysis using polyclonal antibody.
  • BACKGROUND: Friend leukaemia integration-1 (FLI-1) antibody is a useful marker for Ewing's sarcoma/primitive neuroectodermal tumour (EWS/PNET) and vascular tumours.
  • However, it is also expressed in subsets of lymphoblastic lymphoma, Merkel cell carcinoma (MCC) and desmoplastic small round cell tumour (DSRCT).
  • AIM: To determine expression of FLI-1 in various benign and malignant neoplasms, by immunohistochemical analysis on 4323 tumours using multiple tumour microarrays, as well as on whole sections.
  • RESULTS: FLI-1 was expressed in 46/62 EWS/PNETs, 2/3 olfactory neuroblastomas, 7/102 small cell carcinomas of the lung, 10/34 MCCs, 1/14 rhabdomyosarcoma, 19/132 non-Hodgkin's lymphomas, 2/3 DSRCTs, and in 53/74 benign and malignant vascular tumours.
  • In addition, 27/508 squamous cell carcinomas, 19/837 adenocarcinomas, 10/400 urothelial bladder cancers, 1/40 basal cell carcinomas, 3/29 liposarcomas, 1/40 glioblastoma multiforme and 9/29 medullar carcinomas of the breast expressed FLI-1.
  • Finally, the sensitivity and specificity of FLI-1 to distinguish EWS/PNET from other small round cell tumours (SRCTs) were 74.2% and 91.6%, respectively.
  • This finding should be kept in mind, especially when using FLI-1 as a marker for finding the primary origin of poorly differentiated metastatic tumour.
  • Finally, despite the expression of FLI-1 in numerous malignancies, it is still considered to be highly sensitive and specific in distinguishing EWS/PNET from other tumour types in general and from other SRCTs in particular.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Neoplasms / metabolism. Proto-Oncogene Protein c-fli-1 / metabolism
  • [MeSH-minor] Carcinoma, Small Cell / diagnosis. Carcinoma, Small Cell / metabolism. Diagnosis, Differential. Humans. Immunoenzyme Techniques. Neoplasms, Germ Cell and Embryonal / diagnosis. Neoplasms, Germ Cell and Embryonal / metabolism. Neuroectodermal Tumors, Primitive / diagnosis. Neuroectodermal Tumors, Primitive / metabolism. Protein Array Analysis / methods. Sarcoma, Ewing / diagnosis. Sarcoma, Ewing / metabolism. Sensitivity and Specificity

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  • (PMID = 16917000.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Proto-Oncogene Protein c-fli-1
  • [Other-IDs] NLM/ PMC1955051
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90. Suárez C, Rodrigo JP, Ferlito A, Cabanillas R, Shaha AR, Rinaldo A: Tumours of familial origin in the head and neck. Oral Oncol; 2006 Nov;42(10):965-78
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  • Individuals with inherited cancer syndromes are at significant risk of developing both benign and malignant tumours as a result of a germline mutation in a specific tumour suppressor gene.
  • No clear correlation of MEN-1 genotype with genotype has emerged to date, and MEN-1 mutation testing in tumours is not used clinically because it have not implications for tumour staging.
  • Finally, the high rate of p16 mutations in squamous cell carcinomas and the association of p16 with familial melanoma propose p16 as an ideal candidate gene predisposing to familial squamous cell carcinomas.
  • [MeSH-minor] Carcinoma, Squamous Cell / genetics. Humans. Multiple Endocrine Neoplasia / genetics. Nasopharyngeal Neoplasms / genetics. Neurofibromatoses / genetics. Paraganglioma / genetics

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  • (PMID = 16857415.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 121
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91. Mazlina S, Putra SH, Shiraz MA, Hazim MY, Roszalina R, Abdul AR: Maxillary sinus tumours--a review of twenty-nine patients treated by maxillectomy approach. Med J Malaysia; 2006 Aug;61(3):284-7
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  • Seventeen patients (59%) presented with malignant tumours while 12 patients (41%) with benign tumours.
  • Inverted papilloma (50%) was the commonest benign tumour and squamous cell carcinoma (36%) was the commonest malignancy.
  • [MeSH-minor] Adult. Carcinoma, Squamous Cell / surgery. Female. Humans. Male. Middle Aged. Papilloma, Inverted / surgery. Retrospective Studies

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  • (PMID = 17240576.001).
  • [ISSN] 0300-5283
  • [Journal-full-title] The Medical journal of Malaysia
  • [ISO-abbreviation] Med. J. Malaysia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
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92. Tamiolakis D, Proimos E, Perogamvrakis GE, Skoulakis CE, Georgiou GC, Papadakis CE: Brushing cytology in cutaneous lesions of the head and neck. J Laryngol Otol; 2007 Jul;121(7):676-9
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  • Our aim was to evaluate its reliability in ulcerative and tumour-like conditions arising in the skin of the head and neck.
  • RESULTS: Cytological analysis identified 63 out of 64 histologically documented malignant tumours (60 primary basal cell and squamous cell carcinomas and three metastatic adenocarcinomas), and 21 out of 22 benign lesions.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Head and Neck Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 17403275.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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93. Chechlinska M, Kowalewska M, Brzoska-Wojtowicz E, Radziszewski J, Ptaszynski K, Rys J, Kaminska J, Nowak R: Squamous cell carcinoma antigen 1 and 2 expression in cultured normal peripheral blood mononuclear cells and in vulvar squamous cell carcinoma. Tumour Biol; 2010 Dec;31(6):559-67
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  • [Title] Squamous cell carcinoma antigen 1 and 2 expression in cultured normal peripheral blood mononuclear cells and in vulvar squamous cell carcinoma.
  • Squamous cell carcinoma antigen (SCCA) is expressed in normal squamous cell epithelia and in squamous cell carcinomas (SCC).
  • Serum levels of SCCA are elevated in patients with benign skin diseases and in patients with SCC.
  • SCCA expression level in normal PBMC is much lower than in the squamous epithelium-derived cells.
  • In VSCC, in addition to tumour itself, metastatic lymph nodes seem also to be a potential source of serum SCCA.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Carcinoma, Squamous Cell / metabolism. Leukocytes, Mononuclear / metabolism. Serpins / metabolism. Vulvar Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cell Line, Tumor. Cells, Cultured. Female. Humans. RNA, Messenger / metabolism

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  • (PMID = 20589490.001).
  • [ISSN] 1423-0380
  • [Journal-full-title] Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • [ISO-abbreviation] Tumour Biol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / RNA, Messenger; 0 / Serpins; 0 / squamous cell carcinoma-related antigen
  • [Other-IDs] NLM/ PMC2953620
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94. Eissa S, Ali HS, Al Tonsi AH, Zaglol A, El Ahmady O: HER2/neu expression in bladder cancer: relationship to cell cycle kinetics. Clin Biochem; 2005 Feb;38(2):142-8
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  • [Title] HER2/neu expression in bladder cancer: relationship to cell cycle kinetics.
  • PATIENTS AND METHODS: Tissue samples were collected from 35 patients with benign bladder lesions, 28 with bilharzial bladder cancer, and 25 with nonbilharzial bladder cancer.
  • Out of the malignant samples, 22 were found to be squamous cell carcinoma and 31 were transitional cell carcinoma.
  • RESULTS: HER2/neu was found to be significantly overexpressed in the malignant group compared to the benign and normal groups (P < 0.001) and no significant difference was found between the bilharzial and nonbilharzial cancer groups or between the transitional and squamous cell carcinoma groups.
  • No significant correlation was found between HER2/neu and stage or grade while it was significantly associated with lymph node status of the tumour (P = 0.02).
  • [MeSH-major] Cell Cycle. Gene Expression Regulation, Neoplastic. Receptor, ErbB-2 / analysis. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Cell Proliferation. DNA / analysis. Flow Cytometry. Humans. Immunoenzyme Techniques. Kinetics

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  • (PMID = 15642276.001).
  • [ISSN] 0009-9120
  • [Journal-full-title] Clinical biochemistry
  • [ISO-abbreviation] Clin. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-49-2 / DNA; EC 2.7.10.1 / Receptor, ErbB-2
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95. Bakhshaee M, Talebmehr M, Taiebi Meibod N, Razmara N: A case of neglected inverted papilloma with invasion to the skin. Dentomaxillofac Radiol; 2007 May;36(4):245-8
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  • Inverted papilloma is an uncommon and locally aggressive benign tumour of the sinonasal region, which tends to recur after surgical resection and is occasionally associated with squamous cell carcinoma.

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  • (PMID = 17536095.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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