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1. Ferri E, Iaderosa GA, Armato E: Atypical fibroxanthoma of the external ear in a cardiac transplant recipient: case report and the causal role of the immunosuppressive therapy. Auris Nasus Larynx; 2008 Jun;35(2):260-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Atypical fibroxanthoma (AF) is an unusual cutaneous fibrohistiocytic tumour that is most commonly found in ENT sun-exposed areas of elderly males.
  • Cardiac transplant patients have an increased incidence of multiple cutaneous neoplasms, but the AF is uncommon.
  • Although this neoplasm is benign, it may mimic spindle cell carcinoma, squamous cell carcinoma, melanoma and soft tissue sarcoma on histologic examination.
  • Immunohistochemical stains for cytokeratin, alpha-1-antichymotrypsin, S100 protein and vimentin may be helpful in differential diagnosis.
  • We present a case of a cardiac transplant recipient who developed, after multiple cutaneous squamous tumours, an AF of external ear following the prolonged immunosuppressive treatment with cyclosporin.
  • [MeSH-major] Ear Neoplasms / pathology. Ear, External. Heart Transplantation. Histiocytoma, Benign Fibrous / pathology
  • [MeSH-minor] Aged. Cyclosporins. Diagnosis, Differential. Humans. Immunosuppressive Agents / adverse effects. Male. Postoperative Complications

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  • (PMID = 17804184.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cyclosporins; 0 / Immunosuppressive Agents
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2. Cranshaw IM, Gikas PD, Fisher C, Thway K, Thomas JM, Hayes AJ: Clinical outcomes of extra-thoracic solitary fibrous tumours. Eur J Surg Oncol; 2009 Sep;35(9):994-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Extra-thoracic solitary fibrous tumours (ESFTs) have traditionally been regarded as indolent neoplasms similar to their intra-thoracic counterparts.
  • PATIENTS/METHODS: All patients with a histopathological diagnosis of solitary fibrous tumour (SFT) who presented to the Royal Marsden Hospital between 1998 and 2006 were reviewed.
  • Locoregional recurrent disease was more common in those with malignant histopathological findings compared to those with benign histopathology (6/18 vs 0/15 p 0.021).
  • The presence of malignant histopathology was the only factor to affect survival with no benign cases dying of disease and malignant cases having a median survival of 59 months (p 0.003).
  • Those tumours with atypical or malignant features on histological examination have poor prognosis and should be managed and followed up in the same manner as other high-grade soft tissue tumours.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. London. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 19345055.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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3. Bidault F, Vanel D, Terrier P, Jalaguier A, Bonvalot S, Pedeutour F, Couturier JM, Dromain C: Liposarcoma or lipoma: does genetics change classic imaging criteria? Eur J Radiol; 2009 Oct;72(1):22-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Differentiating benign from malignant fatty tumours has always been very difficult for both radiologists and pathologists.
  • Cytogenetic and molecular genetic analyses provide complementary tools for differentiating soft tissue tumours.
  • Nineteen patients with a fatty tumour were included.
  • The imaging diagnosis of benign or malignant lesions was accurate in 15 cases, with 4 false positives for malignancy.
  • Erroneous criteria were a large size (4 cases), and a mass that was not purely fatty.
  • In conclusion, the main pitfall for a false positive radiological diagnosis of liposarcoma is certainly a large-sized tumour.
  • Cytogenetic and molecular genetic analyses contribute to the diagnosis and can be performed at the same time with a core biopsy.
  • [MeSH-major] Diagnostic Imaging / methods. Genetic Predisposition to Disease / genetics. Lipoma / diagnosis. Lipoma / genetics. Liposarcoma / diagnosis. Liposarcoma / genetics. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 19525076.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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4. Tetikkurt C, Tetikkurt S, Bayar N: Diagnosis of elastofibroma. Can Respir J; 2008 May-Jun;15(4):217-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis of elastofibroma.
  • Elastofibroma is a relatively rare soft tissue mass.
  • It is a degenerative benign neoplasm with the clinical appearence of a malignant tumour.
  • The present report describes the case of a 70-year-old man with bilateral elastofibroma.
  • The diagnosis was established with needle aspiration biopsy and positron emission tomography/computed tomography.
  • The present case suggests that needle aspiration biopsy and positron emission tomography/computed tomography are highly useful in the diagnosis of this rare, benign tumour.
  • [MeSH-major] Fibroma / diagnosis. Shoulder. Soft Tissue Neoplasms / diagnosis

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  • [Cites] AJR Am J Roentgenol. 1992 Sep;159(3):575-9 [1503030.001]
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  • (PMID = 18551204.001).
  • [ISSN] 1198-2241
  • [Journal-full-title] Canadian respiratory journal
  • [ISO-abbreviation] Can. Respir. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2677955
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5. Willems SM, Debiec-Rychter M, Szuhai K, Hogendoorn PC, Sciot R: Local recurrence of myxofibrosarcoma is associated with increase in tumour grade and cytogenetic aberrations, suggesting a multistep tumour progression model. Mod Pathol; 2006 Mar;19(3):407-16
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  • [Title] Local recurrence of myxofibrosarcoma is associated with increase in tumour grade and cytogenetic aberrations, suggesting a multistep tumour progression model.
  • Myxofibrosarcoma is one of the most frequent soft tissue tumours in elderly patients, mostly arising in the extremities.
  • The differential diagnosis contains several other (benign) myxoid soft tissue tumours.
  • However, no tumour-specific chromosomal abnormalities could be withdrawn.
  • Since the chromosomal aberrations found were not tumour type specific, they seem to be rather the result of secondary events in tumour progression and tumour genetic instability.
  • [MeSH-major] Chromosome Aberrations. Fibrosarcoma / pathology. Neoplasm Recurrence, Local / pathology

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  • (PMID = 16415793.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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6. Casanova D, Norat F, Bardot J, Magalon G: [Cutaneous hemangioma: clinical aspects]. Ann Chir Plast Esthet; 2006 Aug-Oct;51(4-5):287-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Infantile cutaneous hemangioma is a benign vascular tumour present at 10% of the infants.
  • Clinical diagnosis is easy in its triphasic typical form with a phase of sometimes brutal postnatal growth, a phase of stabilization and a phase of slow secondary regression.
  • Classically, it is presented in the form of a mass or stains cutaneous red, of a subcutaneous mass or, generally, of a mixed form associating the two aspects.
  • [MeSH-major] Hemangioma / physiopathology. Skin Neoplasms / physiopathology
  • [MeSH-minor] Child, Preschool. Humans. Infant. Neovascularization, Pathologic / physiopathology. Remission, Spontaneous. Soft Tissue Neoplasms / classification. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / physiopathology

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  • (PMID = 16997447.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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7. Kandil DH, Kida M, Laub DR, Cooper K: Sarcomatous transformation in a cellular angiofibroma: a case report. J Clin Pathol; 2009 Oct;62(10):945-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cellular angiofibroma is a rare benign mesenchymal tumour of middle-aged adults.
  • This tumour is usually located in the vulvovaginal or inguinoscrotal region.
  • This report describes the case of a patient with a 3.5 cm subcutaneous mass, 2 cm below the left anterior superior iliac spine.
  • Histologically, the tumour was composed primarily of cytologically bland spindle cells set in a collagenous stroma, with multiple dilated vessels.
  • Other areas showed an abrupt transition to hypercellular sarcomatous elements, including pleomorphic cells with high mitotic activity.
  • The tumour cells were diffusely positive for vimentin and factor XIIIa, and weakly positive for CD34.
  • [MeSH-major] Angiofibroma / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Disease Progression. Fatal Outcome. Humans. Neoplasms, Second Primary

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  • (PMID = 19783726.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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8. Verma S, Varma M, Kala S, Singh R: Giant lipoma of posterior neck with bleeding decubitus ulcer: a rare entity. J Cutan Aesthet Surg; 2010 May;3(2):119-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Giant lipomas are benign soft tissue tumours.
  • Bleeding pressure ulcer in this giant tumour is a rare presentation.

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  • (PMID = 21031074.001).
  • [ISSN] 0974-5157
  • [Journal-full-title] Journal of cutaneous and aesthetic surgery
  • [ISO-abbreviation] J Cutan Aesthet Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2956954
  • [Keywords] NOTNLM ; Giant lipoma / bleeding / pressure ulcer
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9. Dray MS, Miller MV: Paget's osteosarcoma and post-radiation osteosarcoma: secondary osteosarcoma at Middlemore Hospital, New Zealand. Pathology; 2008 Oct;40(6):604-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: A search through the files of the New Zealand Bone and Soft Tissue Tumour Registry was performed, patients were identified and the relevant details were collated.
  • Index lesions included benign or malignant osseous and non-osseous conditions.
  • The average age at diagnosis of the index lesion was 30.1 years and the average latent period was 13.5 years.
  • [MeSH-major] Bone Neoplasms / pathology. Neoplasms, Radiation-Induced / pathology. Neoplasms, Second Primary / pathology. Osteitis Deformans / pathology. Osteosarcoma / pathology


10. Kubiena H, Mädel C, Roka J, Burjak S, Frey E, Frey M: [In-vitro suspension model of haemangioma vascular endothelial cells (HVECs)]. Handchir Mikrochir Plast Chir; 2009 Apr;41(2):107-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Haemangioma is the most common tumour of infancy.
  • Its biological behaviour is one of a benign nature and characterised by a typical biphasic growth pattern.
  • In-vitro models reported so far have provided new insights in the tumour's biology and have identified possible targets for pharmacological agents.
  • MATERIAL AND METHODS: Tissue samples isolated from four haemangiomas (H1-H4) during the proliferation phase were cultivated in four different ways: H1 was cultivated in an MCDB-131 medium whereas for the H2 samples EGM2-MV medium was used.
  • In the H3 series dispase enabled an immediate isolation of pure HVECs from the tissue sample which were cultivated under EMG2-MV medium.
  • CONCLUSIONS: Research on tumour-specific processes as well as possible pharmacological targets necessitates a stable in-vitro model of proliferating HVECs.
  • [MeSH-major] Cell Division / physiology. Endothelium, Vascular / pathology. Hemangioma / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology. Tumor Stem Cell Assay / methods

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  • (PMID = 19259919.001).
  • [ISSN] 1439-3980
  • [Journal-full-title] Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der Peripheren Nerven und Gefässe : Organ der Vereinigung der Deutschen Plastischen Chirurgen
  • [ISO-abbreviation] Handchir Mikrochir Plast Chir
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Culture Media
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11. Sarikcioglu L, Demirel BM, Ozsoy U, Gurer EI, Oguz N, Ucar Y: Angiolipoma located inside the obturator canal and supplied by the umbilical artery. Ann Anat; 2007;189(1):75-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • During dissection of the retropubic region of a 55-year-old female cadaver, we encountered an angiolipoma located inside the obturator canal which was connected to the wall of the urinary bladder by a fibrous cord.
  • Microscopically the benign soft tissue tumor was characterized by lobules of mature adipocytes and densely distributed networks of small and larger blood vessels, thus resembling typical histological features of an angiolipoma.

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  • (PMID = 17319612.001).
  • [ISSN] 0940-9602
  • [Journal-full-title] Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft
  • [ISO-abbreviation] Ann. Anat.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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12. Bourelle S, Viehweger E, Launay F, Quilichini B, Bouvier C, Hagemeijer A, Jouve JL, Bollini G: Lipoblastoma and lipoblastomatosis. J Pediatr Orthop B; 2006 Sep;15(5):356-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report two cases of lipoblastoma of the buttock in a 10-month-old boy and a 20-month-old girl, the first with rearrangement of chromosome 8 and the second without cytogenetic abnormality, and one case of lipoblastomatosis of a leg in a 6-month-old boy with a normal karyotype but with a rearrangement of the PLAG1 gene.
  • Lipoblastoma and lipoblastomatosis are two different presentation of the same rare benign soft tissue mesenchymal tumour arising from fetal white fat and occurring almost exclusively in young children under 3 years.
  • These neoplasms have no malignant potential but may recur in cases of incomplete resection.
  • Histological diagnosis sometimes used to be difficult because of the close resemblance of the lesion with myxoïd liposarcoma.
  • Nowadays, cytogenetic analysis may contribute to the diagnosis by showing abnormalities of the long arm of chromosome 8, leading to rearrangement of the PLAG1 gene.
  • Actual advances in cytogenetic molecular analysis may aid in accurate diagnosis.
  • [MeSH-major] Lipoma / pathology. Lipomatosis / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16891964.001).
  • [ISSN] 1060-152X
  • [Journal-full-title] Journal of pediatric orthopedics. Part B
  • [ISO-abbreviation] J Pediatr Orthop B
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / PLAG1 protein, human
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13. Ruiz Tovar J, Reguero Callejas ME, Aláez Chillarón AB, Ramiro Pérez C, Collado Guirao MV, Rojo Blanco R, Muñoz Martín-Cámara J, González-Palacios F, García Villanueva A: Mammary hamartoma. Clin Transl Oncol; 2006 Apr;8(4):290-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Mammary hamartomas are rare benign breast lumps.
  • They are usually painless, wellcircumscribed, mobile and with no adherence to skin or muscle, composed of varying amounts of fat, glandular and fibrous tissue.
  • Because there is no distinct pathological feature, a correlation with the clinical findings and image techniques is necessary in order to achieve a correct diagnosis of the pathology.
  • The initial manifestation was in all cases a well-circumscribed, soft, palpable breast lump.
  • Other diagnostic procedures used in the diagnosis were Ultrasound, Fine Needle Aspiration Cytology and Needle Core Biopsy.
  • We describe a case of recurrence after excision of the lump in a more aggressive histological form and one patient who presented the coexistence of a mammary hamartoma and an invasive ductal carcinoma.
  • CONCLUSION: Mammary hamartoma is an uncommon breast tumour.
  • [MeSH-minor] Adult. Aged. Biopsy, Fine-Needle. Biopsy, Needle. Breast Neoplasms / complications. Breast Neoplasms / diagnosis. Carcinoma, Ductal, Breast / complications. Carcinoma, Ductal, Breast / diagnosis. Female. Humans. Mammography. Middle Aged. Recurrence. Retrospective Studies. Ultrasonography, Mammary

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  • (PMID = 16648106.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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14. Estrella EP, Lee EY: Lipoblastoma of the hand treated with excision and ligament reconstruction: a case report. Hand Surg; 2008;13(2):103-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lipoblastoma of the hand is a rare benign tumour of infancy.
  • Although benign, the tumour can present as a large mass.
  • We present a case of a two-year-old female with a large, slowly growing soft tissue mass between the second and third metacarpal of the right hand.

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  • (PMID = 19054842.001).
  • [ISSN] 0218-8104
  • [Journal-full-title] Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand
  • [ISO-abbreviation] Hand Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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15. Chandrasekar CR, Grimer RJ, Carter SR, Tillman RM, Abudu A, Davies AM, Sumathi VP: Elastofibroma dorsi: an uncommon benign pseudotumour. Sarcoma; 2008;2008:756565
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Elastofibroma dorsi: an uncommon benign pseudotumour.
  • Elastofibroma dorsi is an uncommon benign soft tissue pseudotumour usually located at the lower pole of the scapula, deep to serratus anterior, and often attached to the periosteum of the ribs, presenting with long history of swelling and occasionally pain and discomfort.
  • This lesion is usually seen in patients over the age of 50 years and is not uncommonly mistaken as a malignant tumour because of its size and location deep to the periscapular muscles.
  • There were 12 males and 3 females, mean age at diagnosis of 68.4 years range 51-79 years.
  • The diagnosis was confirmed by MRI in 3 patients, excision biopsy in 3 patients, trucut biopsy in 8 patients and open biopsy in 1 patient.

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  • (PMID = 18382611.001).
  • [ISSN] 1357-714X
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2276598
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16. Browne TJ, Fletcher CD: Haemosiderotic fibrolipomatous tumour (so-called haemosiderotic fibrohistiocytic lipomatous tumour): analysis of 13 new cases in support of a distinct entity. Histopathology; 2006 Mar;48(4):453-61
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  • [Title] Haemosiderotic fibrolipomatous tumour (so-called haemosiderotic fibrohistiocytic lipomatous tumour): analysis of 13 new cases in support of a distinct entity.
  • AIMS: To describe 13 new cases of a rare soft tissue neoplasm currently known as haemosiderotic fibrohistiocytic lipomatous tumour (HFHLL) and to further its characterization.
  • CONCLUSIONS: So-called HFHLL, better termed haemosiderotic fibrolipomatous tumour, is a distinct lesion characterized by an admixture of fibroblastic spindle cells, mature adipocytes and haemosiderin pigmentation, shows a predilection for the distal extremities and quite often recurs locally.
  • [MeSH-major] Hemosiderosis / pathology. Histiocytoma, Benign Fibrous / pathology. Lipoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16487368.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD34; 9011-92-1 / Hemosiderin
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17. Delaney D, Diss TC, Presneau N, Hing S, Berisha F, Idowu BD, O'Donnell P, Skinner JA, Tirabosco R, Flanagan AM: GNAS1 mutations occur more commonly than previously thought in intramuscular myxoma. Mod Pathol; 2009 May;22(5):718-24
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  • Mutation detection plays an important role in diagnostic pathology, not only in providing a tissue diagnosis, but also in predicting response to antitumourigenic agents.
  • Intramuscular myxoma is a rare benign soft tissue neoplasm that occurs sporadically and less commonly in association with fibrous dysplasia (Mazabraud's syndrome).
  • Mutations were detected in two cases where a diagnosis of low-grade myxofibrosarcoma had been favoured over intramuscular myxoma.
  • [MeSH-major] GTP-Binding Protein alpha Subunits, Gs / genetics. Myxoma / genetics. Polymerase Chain Reaction / methods. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Cold Temperature. DNA Mutational Analysis. Diagnosis, Differential. Fibrosarcoma / genetics. Fibrosarcoma / pathology. Humans. Mutation. Sensitivity and Specificity

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  • (PMID = 19287459.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.6.1.- / GNAS protein, human; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gs
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18. Tanaka K, Yoshikawa R, Yanagi H, Gega M, Fujiwara Y, Hashimoto-Tamaoki T, Hirota S, Tsujimura T, Tomita N: Regression of sporadic intra-abdominal desmoid tumour following administration of non-steroidal anti-inflammatory drug. World J Surg Oncol; 2008;6:17
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  • [Title] Regression of sporadic intra-abdominal desmoid tumour following administration of non-steroidal anti-inflammatory drug.
  • BACKGROUND: Desmoid tumours or fibromatoses are rare entities characterized by the benign proliferation of fibroblasts, which can be life-threatening due to their locally aggressive properties.
  • Computed tomography showed an abnormal multilocular soft-tissue mass (95 x 70 mm) in the right pelvis, which was revealed by biopsy to be a desmoid tumour.
  • Immunohistochemical analysis showed that the tumour cells expressed vimentin, but not smooth-muscle actin, CD34, or desmin.
  • Two years after the commencement of non-steroidal anti-inflammatory drug administration, computed tomography showed a decrease in tumour size (63 x 49 mm), and the disappearance of intratumoural septa.
  • [MeSH-major] Abdominal Neoplasms / drug therapy. Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Fibromatosis, Abdominal / drug therapy. Fibromatosis, Aggressive / drug therapy

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  • (PMID = 18257933.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal
  • [Other-IDs] NLM/ PMC2270274
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19. Brookes MJ, Bourke AG: Radiological appearances of papillary breast lesions. Clin Radiol; 2008 Nov;63(11):1265-73
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  • This review illustrates the varied appearances of benign and malignant papillary breast tumours, as identified by a breast cancer-screening programme.
  • The commonest mammographic appearance of a papillary tumour is as a soft-tissue mass, with calcification present in less than half of cases.
  • Despite a benign histology on core biopsy, an argument exists for complete surgical excision of all papillary tumours, as a significant proportion of papillomas will contain foci of atypia or overt malignant change.
  • [MeSH-major] Breast Neoplasms / radiography. Papilloma, Intraductal / radiography

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  • (PMID = 18929044.001).
  • [ISSN] 1365-229X
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 28
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20. Diniz MB, Giro Elisa MA, Zuanon Angela CC, Costa CA, Hebling J: Congenital epulis: a rare benign tumor in the newborn. J Indian Soc Pedod Prev Dent; 2010 Jul-Sep;28(3):230-3
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  • [Title] Congenital epulis: a rare benign tumor in the newborn.
  • Congenital epulis (CE) of the newborn is a rare benign soft tissue tumor that presents at birth.
  • A decisive diagnosis is made by histopathologic analysis as other newborn lesions can be incorrectly diagnosed as CE.
  • This article presents a case report of a female infant who presented a fibrotic mass in the primary lateral incisor and canine region of the maxillary alveolar ridge.
  • [MeSH-major] Gingival Neoplasms / congenital. Gingival Neoplasms / pathology

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  • (PMID = 21157060.001).
  • [ISSN] 0970-4388
  • [Journal-full-title] Journal of the Indian Society of Pedodontics and Preventive Dentistry
  • [ISO-abbreviation] J Indian Soc Pedod Prev Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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21. Manduch M, Oliveira AM, Nascimento AG, Folpe AL: Massive localised lymphoedema: a clinicopathological study of 22 cases and review of the literature. J Clin Pathol; 2009 Sep;62(9):808-11
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  • 22 morbidly obese adults (mean patient weight 186 kg) presented with unilateral, large soft tissue lesions of longstanding duration.
  • Clinically, most lesions were regarded as representing benign processes, including pedunculated lipoma, lymphocoele or recurrent cellulites, although soft tissue sarcoma was also suspected in two cases.
  • Multinucleated fibroblastic cells, marked vascular proliferation, moderate stromal cellularity and fascicular growth raised concern among referring pathologists for atypical lipomatous tumour/well differentiated liposarcoma, angiosarcoma, and a fibroblastic neoplasm such as fibromatosis in 10, 2 and 1 case, respectively.
  • CONCLUSION: The diagnosis of MLL continues to be challenging, in particular for pathologists.
  • [MeSH-minor] Adult. Aged. Cellulitis / diagnosis. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Leg / pathology. Lipoma / diagnosis. Lymphocele / diagnosis. Male. Middle Aged. Obesity, Morbid / complications. Retrospective Studies. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 19734477.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 23
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22. Seoane J, Van der Waal I, Van der Waal RI, Cameselle-Teijeiro J, Antón I, Tardio A, Alcázar-Otero JJ, Varela-Centelles P, Diz P: Metastatic tumours to the oral cavity: a survival study with a special focus on gingival metastases. J Clin Periodontol; 2009 Jun;36(6):488-92
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  • MATERIALS AND METHODS: A series of 39 patients were studied, analysing age, gender, primary tumour site, oral metastases site and histological type.
  • Gingival metastases represented 63.6% of all oral soft tissue metastases (7/11).
  • The average time between primary tumour diagnosis and appearance of the gingival metastases was 9.7+/-13.4 months.
  • The median survival time since gingival metastases appearance was 5.2 months [95% confidence interval (CI)=0-13.6]; no statistically significant difference with other oral locations was found by the Kaplan-Meier curves (log rank: 0.29; p>0.05).
  • PRACTICAL IMPLICATIONS: The data in this paper show that 25% (and in other studies up to 37%) of oral metastases came from unknown primary tumours; thus a biopsy with histopathologic analysis is mandatory for every patient with a gingival mass.
  • Dental practitioners should suspect that gingival masses mimicking benign or inflammatory lesions may represent a sign of underlying malignant tumours.
  • [MeSH-major] Gingival Neoplasms / secondary. Mouth Neoplasms / secondary
  • [MeSH-minor] Age Factors. Aged. Aged, 80 and over. Breast Neoplasms / pathology. Female. Follow-Up Studies. Humans. Kidney Neoplasms / pathology. Lung Neoplasms / pathology. Male. Mandibular Neoplasms / secondary. Maxillary Neoplasms / secondary. Middle Aged. Neoplasms, Unknown Primary / pathology. Netherlands / epidemiology. Prognosis. Retrospective Studies. Sex Factors. Spain / epidemiology. Survival Rate. Time Factors

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  • (PMID = 19508248.001).
  • [ISSN] 1600-051X
  • [Journal-full-title] Journal of clinical periodontology
  • [ISO-abbreviation] J. Clin. Periodontol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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23. Keyriläinen J, Fernández M, Fiedler S, Bravin A, Karjalainen-Lindsberg ML, Virkkunen P, Elo EM, Tenhunen M, Suortti P, Thomlinson W: Visualisation of calcifications and thin collagen strands in human breast tumour specimens by the diffraction-enhanced imaging technique: a comparison with conventional mammography and histology. Eur J Radiol; 2005 Feb;53(2):226-37
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  • [Title] Visualisation of calcifications and thin collagen strands in human breast tumour specimens by the diffraction-enhanced imaging technique: a comparison with conventional mammography and histology.
  • Six excised human breast tissue specimens carrying benign and malignant tumours were examined with the diffraction-enhanced imaging technique.
  • Fine details of the structures such as strands of collagen and contours between glandular and adipose tissue, which are barely visible at the contrast detection limit in the conventional absorption-based mammograms, are clearly visible in the diffraction-enhanced images.
  • Microscopic study of the stained histopathological sections unequivocally confirms the correlation of the radiographic findings with the morphologic changes in specimens.
  • An increased soft tissue contrast and a combination of information obtained with disparate diffraction-enhanced images provide better visibility of mammographically indistinguishable features.
  • This kind of additional structural information of the breast tissue is required to improve assessment accuracy and earlier detection of the breast lesions.
  • [MeSH-major] Breast Neoplasms / radiography. Calcinosis / radiography. Collagen. Radiographic Image Enhancement / methods. X-Ray Diffraction / methods

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  • (PMID = 15664286.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 9007-34-5 / Collagen
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24. Manor E, Sion-Vardy N, Nash M, Bodner L: Angiomyoma of buccal vestibule: a rare case with a normal karyotype. J Laryngol Otol; 2007 Dec;121(12):1210-2
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  • Angiomyoma is an uncommon, benign, soft tissue tumour characterised by bundles of smooth muscle cells intermixed with numerous vascular channels, which usually develops in the lower extremities.
  • [MeSH-major] Angiomyoma / diagnosis. Mouth Neoplasms / diagnosis
  • [MeSH-minor] Adult. Cheek. Diagnosis, Differential. Humans. Male

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  • (PMID = 17524173.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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25. Cribb GL, Cool WP, Ford DJ, Mangham DC: Giant lipomatous tumours of the hand and forearm. J Hand Surg Br; 2005 Oct;30(5):509-12
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  • This study examines the presentation, management and outcomes of a series of 10 patients with giant lipomatous tumours (defined as greater than 5 cm diameter) of the hand and forearm who presented to our orthopaedic oncology service.
  • All patients underwent local staging and were discussed at our multidisciplinary tumour meeting prior to definitive surgery.
  • In all cases, neurovascular structures required mobilization in order to excise the tumour.
  • Seven of the tumours were benign lipomas and one was a neural fibrolipoma.
  • The other two were well differentiated lipoma-like liposarcomas/atypical lipomatous tumours.
  • Giant lipomas and well differentiated lipoma-like liposarcomas/atypical lipomatous tumours of the hand and forearm present infrequently and a multidisciplinary approach is recommended in the investigation and surgical management of these patients.
  • [MeSH-major] Forearm / surgery. Hand / surgery. Lipomatosis / surgery. Liposarcoma / surgery. Soft Tissue Neoplasms / surgery

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  • (PMID = 15992974.001).
  • [ISSN] 0266-7681
  • [Journal-full-title] Journal of hand surgery (Edinburgh, Scotland)
  • [ISO-abbreviation] J Hand Surg Br
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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26. Uysal A, Kayiran O, Cuzdan SS, Bektas CI, Aslan G, Caydere M: Maxillary sinus lipoma: an unanticipated diagnosis. J Craniofac Surg; 2007 Sep;18(5):1153-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Maxillary sinus lipoma: an unanticipated diagnosis.
  • Subcutaneous tissue gives rise to numerous lesions such as lipoma, the most common benign soft tissue tumors.
  • In addition, craniofacial involvement of intraosseous lipoma may be misdiagnosed as a fibroosseous tumour such as fibrous dysplasia.
  • [MeSH-major] Lipoma / pathology. Maxillary Sinus Neoplasms / pathology
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Female. Humans

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  • (PMID = 17912102.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Klijanienko J, Caillaud JM, Lagacé R: Cytohistologic correlations in schwannomas (neurilemmomas), including "ancient," cellular, and epithelioid variants. Diagn Cytopathol; 2006 Aug;34(8):517-22
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  • Schwannoma accounts for one of the most common benign mesenchymal neoplasms of soft tissues.
  • Original cytologic diagnosis was schwannoma in 13 (38.2%) cases, benign soft tissue tumor in 11 (32.4%), pleomorphic adenoma in 2 (6%) cases, angioma in 1 (2.9%) case, nodular fasciitis in 1 (2.9%) case, suspicious in 3 (8.8%) cases, and not satisfactory in 3 (8.8%) cases.
  • Similarly, cyto-nuclear atypia was more frequent in classical subtype than in other subtypes.
  • Schwannoma should be differentiated from well-differentiated malignant peripheral nerve sheath tumor, neurofibroma, and pleomorphic adenoma, in the last instance particularly for head and neck lesions.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Neurilemmoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Reproducibility of Results

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16850489.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Rose B, Tamvakopoulos GS, Yeung E, Pollock R, Skinner J, Briggs T, Cannon S: Granular cell tumours: a rare entity in the musculoskeletal system. Sarcoma; 2009;2009:765927
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  • Granular Cell Tumours are rare mesenchymal soft tissue tumours that arise throughout the body and are believed to be of neural origin.
  • They often present as asymptomatic, slow-growing, benign, solitary lesions but may be multifocal.
  • We identified eleven cases in ten patients treated surgically and followed-up for a period of over 6 years in our regional bone and soft tissue tumour centre.
  • Histopathological and immunohistochemical analysis revealed the classical granular cell tumour features in all cases.
  • We believe this case series to be the largest of its type in patients presenting to an orthopaedic soft tissue tumour unit.
  • We present our findings and correlate them with findings of other series in the literature.

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  • (PMID = 20169099.001).
  • [ISSN] 1369-1643
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2821775
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29. Friedrich RE, Zustin J, Scheuer HA: Adenomatoid odontogenic tumour of the mandible. Anticancer Res; 2010 May;30(5):1787-92
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  • [Title] Adenomatoid odontogenic tumour of the mandible.
  • Adenomatoid odontogenic tumour (AOT) is a benign tumour of odontogenic origin.
  • The differential diagnosis of AOT is crucial in terms of surgical management.
  • The 23-year old male patient presented in this case study was referred to the maxillofacial surgery clinic due to the incidental radiological finding of a large osteolytic lesion of the anterior mandible with a retained permanent canine at the base of the bone.
  • Surgery revealed a bone defect with a deformed, incomplete tooth inside a granulation-like soft tissue.
  • The tooth was extracted and the soft tissues were excavated.
  • Some areas of the tumour were alpha-smooth-muscle-actin positive, indicating a myoepithelial differentiation.
  • Differential diagnosis of AOT to other odontogenic tumours, such as ameloblastoma, is crucial for therapy.
  • Exact morphological diagnosis avoids extensive ablative surgery.
  • [MeSH-major] Mandibular Neoplasms / diagnosis. Odontogenic Tumors / diagnosis

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  • (PMID = 20592380.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Actins; 68238-35-7 / Keratins
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30. Bara T, Bancu S, Bara T Jr, Mureşan M, Bancu L, Azamfirei L, Podeanu D, Mureşan S: [Gastric stromal tumor with liver and subcutaneus metastasis. Case report]. Chirurgia (Bucur); 2009 Sep-Oct;104(5):621-4
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  • [Title] [Gastric stromal tumor with liver and subcutaneus metastasis. Case report].
  • [Transliterated title] Tumoră stromală gastrică cu metastaze hepatice şi subcutanate. Prezentare de caz.
  • Very importants factors for grading are the tumour localisation, the invasion of serosa or mucosa, the dimensions of tumour and the number of mytosis.
  • We present a case with haemoragic gastric stromal tumour, with small dimensions, which was initially diagnosed as a "benign" tumour.
  • CONCLUSIONS: The gastrointestinals stromal tumours represent a very rare group of digestive tract tumors, with malignant potentially evolution; the first choice of treatment is surgery, with complete ablation of the tumour.
  • [MeSH-major] Gastrointestinal Stromal Tumors / secondary. Liver Neoplasms / secondary. Soft Tissue Neoplasms / secondary. Stomach Neoplasms / pathology

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  • (PMID = 19943565.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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31. Arioni C, Bellini C, Oddone M, Risso FM, Scopesi F, Nozza P, Serra G, Tomà P: Congenital fibrous hamartoma of the knee. Pediatr Radiol; 2006 May;36(5):453-5
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  • Radiography, sonography and MRI suggested a soft-tissue tumour.
  • After surgical excision, histology showed the presence of fibrous and mesenchymal tissue, with mature adipose tissue.
  • Among soft-tissue tumours, fibrous hamartoma of infancy is a rare and benign lesion, occurring in the first 2 years of life.
  • The tumour mainly affects the trunk, axilla, and upper extremities.
  • [MeSH-major] Hamartoma / congenital. Knee / pathology. Soft Tissue Neoplasms / congenital

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  • [Cites] Pediatr Dev Pathol. 1999 May-Jun;2(3):236-43 [10191347.001]
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  • (PMID = 16532345.001).
  • [ISSN] 0301-0449
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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32. Sargenti-Neto S, Brazão-Silva MT, do Nascimento Souza KC, de Faria PR, Durighetto-Júnior AF, Loyola AM, Cardoso SV: Multicentric granular cell tumor: report of a patient with oral and cutaneous lesions. Br J Oral Maxillofac Surg; 2009 Jan;47(1):62-4
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  • [Title] Multicentric granular cell tumor: report of a patient with oral and cutaneous lesions.
  • Granular cell tumor (GCT) is an uncommon benign neoplasm of soft tissue that characteristically affects the oral cavity, with increased frequency in the tongue.
  • [MeSH-major] Granular Cell Tumor / pathology. Lip Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Genital Neoplasms, Female / surgery. Humans. Neoplasm Recurrence, Local. Perineum / pathology. Perineum / surgery

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  • (PMID = 18976838.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
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33. Landen S, Ballet T, Kessler R, Badic B, Costache M, Dobos S, Delugeau V: Tuberculosis diagnosed after major hepatectomy for suspected malignancy. Acta Chir Belg; 2010 Mar-Apr;110(2):221-4
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  • Ultrasound and computed tomography scan revealed a 3.8 cm soft tissue mass.
  • Positron emission tomography scan showed intense uptake, corroborating the diagnosis of a colonic liver metastasis.
  • Major hepatectomy was performed but pathology revealed that the lesion was in fact a benign tuberculosis pseudo-tumour.
  • The diagnosis is often made only after hepatectomy for suspected malignancy.
  • The increasing use of potent anticancer chemotherapy may favour the reactivation of quiescent tuberculosis, posing a difficult differential diagnosis with liver metastases.
  • [MeSH-major] Hepatectomy. Liver Neoplasms / diagnosis. Tuberculosis, Hepatic / diagnosis
  • [MeSH-minor] Adenocarcinoma / complications. Aged. Colonic Neoplasms / complications. Diagnosis, Differential. Humans. Male

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  • (PMID = 20514839.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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34. Dong MJ, Zhou GY: [Imaging diagnosis of hemangioma in infants]. Shanghai Kou Qiang Yi Xue; 2008 Apr;17(2):221-4
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  • [Title] [Imaging diagnosis of hemangioma in infants].
  • Hemangioma is the most commonly benign tumor of soft tissue tumors in infants.
  • In this article, the current situation of application with all imaging examinations used in diagnosis of hemangioma is reviewed.
  • [MeSH-major] Hemangioma / diagnosis

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  • (PMID = 18470434.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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35. Ausmus GG, Piliang MP, Bergfeld WF, Goldblum JR: Soft-tissue perineurioma in a 20-year-old patient with neurofibromatosis type 1 (NF1): report of a case and review of the literature. J Cutan Pathol; 2007 Sep;34(9):726-30
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  • [Title] Soft-tissue perineurioma in a 20-year-old patient with neurofibromatosis type 1 (NF1): report of a case and review of the literature.
  • BACKGROUND: Perineurioma is a rare benign soft-tissue tumor composed of cells showing differentiation toward the perineurial cells of the nerve sheath.
  • Although mutations in the neurofibromatosis 2 (NF2) gene have been documented in this tumor, there is no known association between perineuriomas and type 1 or 2 NF.
  • METHODS: This is the first report of a case of soft-tissue perineurioma occurring in a patient with NF1.
  • RESULTS: Histopathologic examination revealed a 2.0-cm well-circumscribed, spindle-cell neoplasm with slender, elongated, bipolar, wavy cytoplasmic processes and wavy, elongated nuclei in a hyalinized stroma with focal myxoid areas.
  • Perineuriomas can be confused with other spindle-cell neoplasms, and relevant features and immunohistochemistry of these lesions are outlined.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Neurofibromatosis 1 / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Female. Humans. Mucin-1 / metabolism. Thorax. Tomography, X-Ray Computed. Treatment Outcome


36. Jarkiewicz-Kochman E, Gołebiowski M, Swiatkowski J, Pacholec E, Rajewski R: Tumours of the metatarsus. Ortop Traumatol Rehabil; 2007 May-Jun;9(3):319-30
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  • Single cases of the following tumours have been discussed: giant cell tumour, metastases (lung, prostate gland), chondroblastoma, aneurysmal bone cyst, Ewing's sarcoma, clear cell carcinoma, osteosarcoma, intraosseous ganglion, chondromyxoid fibroma and granuloma.
  • The aim of the present study was to carry out a systematic examination of metatarsal tumours with regard to methods of diagnosis (location) and morphology.
  • RESULTS: Most of the metatarsal tumours were benign.
  • 4. The frequently unequivocal presentation of metatarsal tumours requires a multidisciplinary diagnosis involving a clinician, a radiologist and a histopathologist.
  • [MeSH-major] Bone Neoplasms / diagnosis. Metatarsal Bones / radiography
  • [MeSH-minor] Adult. Bone Cysts, Aneurysmal / diagnosis. Diagnosis, Differential. Female. Giant Cell Tumor of Bone / diagnosis. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Osteochondroma / diagnosis. Osteoma / diagnosis. Sarcoma, Synovial / diagnosis. Soft Tissue Neoplasms / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 17721430.001).
  • [ISSN] 1509-3492
  • [Journal-full-title] Ortopedia, traumatologia, rehabilitacja
  • [ISO-abbreviation] Ortop Traumatol Rehabil
  • [Language] eng; pol
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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37. Singh R, Sharma AK, Magu NK, Kaur KP, Sen R, Magu S: Extraskeletal osteochondroma in the nape of the neck: a case report. J Orthop Surg (Hong Kong); 2006 Aug;14(2):192-5
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  • Extraskeletal osteochondroma in the nape of the neck is rare and its pathological diagnosis is based on radiological and histopathological examination.
  • It is vital that such a diagnosis be considered when a discrete, ossified mass is localised in soft tissues, even at atypical sites.
  • Differential diagnoses include myositis ossificans, a lipomatous lesion, a pseudomalignant osseous tumour, an ossifying fibromyxoid tumour, an extraskeletal chondroma with endochondral ossification, synovial (osteo) chondromatosis, tumoural calcinosis, a synovial sarcoma, and an extraskeletal osteosarcoma.
  • Clinical awareness of this benign entity is important as no malignant transformation or metastasis has been reported.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Osteochondroma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Tomography, X-Ray Computed


38. Iascone C, Sadighi A, Ruperto M, Paliotta A, Borrini F, Mingazzini P: Pleomorphic hyalinizing angiectatic tumour of the mesorectal soft tissue. A case report and review of the literatre. Chir Ital; 2008 Jan-Feb;60(1):159-63
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  • [Title] Pleomorphic hyalinizing angiectatic tumour of the mesorectal soft tissue. A case report and review of the literatre.
  • Pleomorphic hyalinizing angiectatic tumours are rare stromal lesions histologically resembling both neurilemoma and malignant fibrous histiocytoma and occurring in the subcutaneous soft tissue of the lower and upper limbs and, less frequently, in the chest wall.
  • The case reported here is one of 22 cases published in the medical literature and describes a pleomorphic hyalinizing angiectatic tumour which was localized in a body cavity and developed in the pelvis.
  • The lesion arising from the left mesorectal tissue was entirely resected.
  • [MeSH-major] Rectal Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Incidental Findings. Middle Aged. Neoplasm Proteins / analysis. Neurilemmoma / diagnosis. Prognosis. Stromal Cells / pathology. Tomography, X-Ray Computed. Vimentin / analysis

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  • (PMID = 18389762.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Vimentin
  • [Number-of-references] 15
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39. West AT, Toms AP, Murphy J, Sultan M: Haemosiderotic fibrohistiocytic lipomatous lesion/tumour of the foot: MRI and histopathology. Skeletal Radiol; 2008 Jan;37(1):71-4
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  • [Title] Haemosiderotic fibrohistiocytic lipomatous lesion/tumour of the foot: MRI and histopathology.
  • This demonstrated an ill-defined lesion confined to the subcutaneous tissues on the dorsum of the foot with heterogeneous intermediate and high T1 and T2 signal suggesting a complex mixture of fat and fibrous elements.
  • A histopathological diagnosis of haemosiderotic fibrohistiocytic lipomatous lesion/tumour (HFLL/T) was made.
  • This is a recently described and rare entity that occurs typically in the subcutaneous tissues of the foot or ankle of middle-aged women.
  • [MeSH-major] Foot / pathology. Hemosiderosis / diagnosis. Histiocytoma, Benign Fibrous / diagnosis. Lipoma / diagnosis. Magnetic Resonance Imaging / methods. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Ankle / pathology. Contrast Media / administration & dosage. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Image Enhancement. Radiography. Rare Diseases. Recurrence

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  • (PMID = 17968543.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
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40. Abou-Nukta F, Fiedler P, Parkash V, Arons J: Superficial acral fibromyxoma of the distal phalanx of the thumb. J Hand Surg Br; 2006 Dec;31(6):619-20
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  • Superficial acral fibromyxoma is an uncommon benign tumour which was first described recently (Fetsch et al., 2001, Human Pathology 32: 704-714).
  • [MeSH-major] Fibroma / surgery. Nails / surgery. Soft Tissue Neoplasms / surgery. Thumb / surgery

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  • (PMID = 16962691.001).
  • [ISSN] 0266-7681
  • [Journal-full-title] Journal of hand surgery (Edinburgh, Scotland)
  • [ISO-abbreviation] J Hand Surg Br
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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41. Takahara M, Ichikawa R, Oda Y, Uchi H, Takeuchi S, Moroi Y, Kiryu H, Furue M: Desmoplastic fibroblastoma: a case presenting as a protruding nodule in the dermis. J Cutan Pathol; 2008 Oct;35 Suppl 1:70-3
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  • Desmoplastic fibroblastoma is a rare, benign, soft tissue tumor.
  • Histological examination from total excision showed a well-circumscribed tumor in the dermis, which comprised of spindle, oval and stellate cells arranged in a haphazard fashion, accompanied by abundant collagenous stroma and inconspicuous vasculature.
  • Immunohistochemically, the tumor cells were positive for vimentin, and focally positive for alpha-smooth muscle actin and muscle-specific actin, but negative for CD34, S-100 protein, desmin and beta-catenin.
  • We diagnosed this case as desmoplastic fibroblastoma arising in the dermis and superficial subcutaneous tissue.
  • [MeSH-major] Fibroma / pathology. Soft Tissue Neoplasms / pathology

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  • [Copyright] Copyright Blackwell Munksgaard 2008.
  • (PMID = 18544056.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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42. De Marchi A, Brach del Prever EM, Linari A, Pozza S, Verga L, Albertini U, Forni M, Gino GC, Comandone A, Brach del Prever AM, Piana R, Faletti C: Accuracy of core-needle biopsy after contrast-enhanced ultrasound in soft-tissue tumours. Eur Radiol; 2010 Nov;20(11):2740-8
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  • [Title] Accuracy of core-needle biopsy after contrast-enhanced ultrasound in soft-tissue tumours.
  • OBJECTIVE: Percutaneous biopsies are gaining acceptance in the diagnosis of soft-tissue tumours.
  • We hypothesised that ultrasound (US) contrast medium could identify the representative area for focus core-needle biopsy (CNB) METHODS: This is a retrospective cohort series of 115 soft-tissue masses treated from January 2007 to November 2008.
  • Accuracy of US-guided CNB after contrast-enhanced US (CEUS) was determined by comparing the histology of the biopsy with the definitive diagnosis in 105 surgically excised samples (42 benign, 63 malignant) and with the expected outcome in the remaining ten malignant cases not surgically treated.
  • RESULTS: Of samples, 94.8% were adequate for diagnosis with 97.1% sensitivity and 92.5% specificity.
  • US contrast medium depicts tumour vascular supply and identifies the representative area(s) for sampling.
  • [MeSH-major] Biopsy, Needle. Contrast Media. Phospholipids. Soft Tissue Neoplasms / pathology. Sulfur Hexafluoride. Ultrasonography, Interventional

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  • (PMID = 20582701.001).
  • [ISSN] 1432-1084
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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43. Archontaki M, Korkolis DP, Arnogiannaki N, Hatzijiannis S, Dendrinos P, Megapanos C, Kassotakis D, Kokkalis G: Histologically malignant solitary fibrous tumour of the anterior thoracic wall: a case report and review of the literature. Case Rep Med; 2010;2010:257167
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  • [Title] Histologically malignant solitary fibrous tumour of the anterior thoracic wall: a case report and review of the literature.
  • Solitary fibrous tumour (SFT) is a rare oncological entity that most often arises in the pleura.
  • Over the past 10 years, the tumour has been described at numerous extrapleural locations.
  • We present the case of a 42-year-old female Caucasian patient with an extrapleural SFT located at the anterior thoracic wall for 22 years, with atypical histological characteristics and clinical features of malignancy.
  • Management consisted of a wide surgical resection, plastic reconstruction, and postoperative radiotherapy.
  • Although extrapleural SFT usually behaves as a benign soft tissue tumour, it can also present with a more aggressive local behavior, including locoregional recurrence or metastasis.
  • In that case, a multidisciplinary approach is required for accurate diagnosis and proper management.

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  • (PMID = 20589090.001).
  • [ISSN] 1687-9635
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2892660
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44. Nishiguchi T, Mochizuki K, Nakayama T, Inoue Y, Ohata K, Wakasa K: A case of synovial sarcoma in the perivertebral space of the neck: clinical presentation, radiological findings and histopathological description. Br J Radiol; 2008 Mar;81(963):e72-4
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  • We report a case of synovial sarcoma in the neck that was initially considered to be a benign soft-tissue tumour.
  • The mass also encased the right vertebral artery and this suggested a malignant soft-tissue tumour.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Sarcoma, Synovial / diagnosis
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Contrast Media. Diagnosis, Differential. Fatal Outcome. Female. Humans. Lung Neoplasms / secondary. Lymph Nodes. Magnetic Resonance Imaging. Neck. Neurofibroma / pathology. Tomography, X-Ray Computed

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  • (PMID = 18270287.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media
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45. Sabah M, Cummins R, Leader M, Kay E: Leiomyosarcoma and malignant fibrous histiocytoma share similar allelic imbalance pattern at 9p. Virchows Arch; 2005 Mar;446(3):251-8
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  • Formalin-fixed, paraffin-embedded tissue from 45 soft tissue sarcomas was analysed for allelic imbalance/loss of heterozygosity (AI/LOH) of chromosome 9.
  • The specimens consisted of 17 cases of soft tissue leiomyosarcoma (LMS), 4 cases of cutaneous LMS, 22 cases of conventional malignant fibrous histiocytoma (MFH) and 2 cases of angiomatoid fibrous histiocytoma.
  • DNA was microdissected from normal and neoplastic tissues.
  • The frequency of allelic imbalance at different loci on chromosome 9p was analysed in LMS and MFH and then compared with values previously examined in synovial sarcoma and malignant peripheral nerve sheath tumour.
  • This locus may point to the existence of a genetically altered tumour suppressor gene involved in the pathogenesis of LMS and MFH.
  • Our results support the hypothesis that MFHs may represent a morphological pathway in tumour progression of LMSs.
  • [MeSH-major] Chromosomes, Human, Pair 9 / genetics. DNA, Neoplasm / genetics. Histiocytoma, Benign Fibrous / genetics. Leiomyosarcoma / genetics. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Allelic Imbalance. Humans. Immunohistochemistry. Loss of Heterozygosity. Microsatellite Repeats. Nerve Sheath Neoplasms / genetics. Polymerase Chain Reaction. Sarcoma, Synovial / genetics

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  • (PMID = 15731925.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
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46. Brisse HJ, Orbach D, Klijanienko J: Soft tissue tumours: imaging strategy. Pediatr Radiol; 2010 Jun;40(6):1019-28
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  • [Title] Soft tissue tumours: imaging strategy.
  • Vascular tumours and malformations, fibrous and fibrohistiocytic tumours and pseudotumours are the most common benign soft-tissue masses observed in children, and can be treated conservatively.
  • Rhabdomyosarcomas are the most frequent malignant tumours, accounting for about half of soft tissue sarcomas.
  • A child referred for a soft-tissue mass should ideally be managed by a multidisciplinary team and primary excision should be proscribed until a definite diagnosis has been established.
  • Clinical examination, conventional radiography and US with Doppler represent the first-line examinations and are sometimes sufficient to make a diagnosis.
  • In all other situations, MRI is mandatory to establish the aggressiveness and extension of the tumour.
  • This technique provides the relevant data to guide the decision regarding tissue sampling.
  • [MeSH-major] Diagnostic Imaging / methods. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 20432021.001).
  • [ISSN] 1432-1998
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 66
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47. Kowatsch E, Feichtinger M, Zemann W, Karpf E, Kärcher H: Extraosseous schwannoma of the mental nerve clinically simulating intraosseous. J Oral Pathol Med; 2006 Sep;35(8):517-9
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  • We report a case of a benign neurilemmoma arising from the right mental nerve.
  • Most of the tumours occur in the soft tissue whereas intraosseous schwannomas are rare.
  • This case report deals with a young patient who was referred to our hospital with an unidentified fast-growing tumour located mainly in the premolar region of the right mandible.
  • The tumour presented as an expansive, unilocular, well defined, radiolucent lesion on orthopantomography.
  • Computerized tomography scans of the mandible helped to identify the solid nature of the tumour.
  • A biopsy was necessary to make the final diagnosis and the tumour was then excised surgically.
  • Postoperative magnetic resonance imaging scans and a histological examination of the surgical specimen showed no signs of neurofibromatosis type 2.
  • [MeSH-major] Cranial Nerve Neoplasms / radiography. Mandibular Nerve / radiography. Neurilemmoma / radiography

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  • (PMID = 16918605.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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48. Chand K, Bhardwaj RK, Rappai TJ: Study of 7 Cases of Giant Cell Tumor of Soft Tissue. Med J Armed Forces India; 2006 Apr;62(2):138-40
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  • [Title] Study of 7 Cases of Giant Cell Tumor of Soft Tissue.
  • BACKGROUND: Primary giant cell tumour of soft tissues is a distinct but uncommon group of neoplasms morphologically identical to osseous giant cell tumor.
  • METHODS: 7 patients with painless growing soft tissue mass, having no attachment to underlying bone, were identified in a four years retrospective study from two zonal hospitals of armed forces.
  • Histologic transition between benign and malignant lesion was present in only one of the 7 patients that recurred after three months of surgery for which she had to be operated again.
  • CONCLUSION: Primary giant cell tumour of soft tissues usually present as a painless mass and needs to be differentiated from other giant cell rich soft tissue tumors.
  • Benign clinical course is expected if the lesion is excised adequately.

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  • (PMID = 27407881.001).
  • [ISSN] 0377-1237
  • [Journal-full-title] Medical journal, Armed Forces India
  • [ISO-abbreviation] Med J Armed Forces India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC4921971
  • [Keywords] NOTNLM ; Giant cell tumour of bone / Giant cell tumour of soft tissue / Malignant fibrous histiocytoma
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49. Tateishi U, Yamaguchi U, Seki K, Terauchi T, Arai Y, Hasegawa T: Glut-1 expression and enhanced glucose metabolism are associated with tumour grade in bone and soft tissue sarcomas: a prospective evaluation by [18F]fluorodeoxyglucose positron emission tomography. Eur J Nucl Med Mol Imaging; 2006 Jun;33(6):683-91
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  • [Title] Glut-1 expression and enhanced glucose metabolism are associated with tumour grade in bone and soft tissue sarcomas: a prospective evaluation by [18F]fluorodeoxyglucose positron emission tomography.
  • PURPOSE: This study was conducted to investigate whether( 18)F-fluorodeoxyglucose (FDG) uptake, quantified by positron emission tomography (PET), correlates with histological variables including tumour grade, cell proliferation, cell cycle control integrity and glucose metabolism in patients with bone and soft tissue sarcomas.
  • METHODS: Eighty-two patients clinically suspected of having a bone or soft tissue sarcoma underwent FDG PET within 1 week prior to operation and 63 patients (mean age 48 years, range 18-74 years) were enrolled in the complete analysis.
  • We excluded 17 patients with pathologically confirmed benign tumours and two patients with uncontrolled diabetes or concomitant malignancy from data analysis.
  • Maximum and average standardised uptake values (SUVs) of the primary lesion were compared with histological variables including tumour differentiation, the presence of necrosis, MIB-1 score, mitotic score, p53 overexpression, MIB-1 grade, mitotic grade and GLUT-1 expression.
  • RESULTS: Significant correlations were found between maximal and mean SUVs and MIB-1 grade, mitotic grade, MIB-1 score, tumour differentiation and mitotic score.
  • CONCLUSION: The enhanced glucose metabolism, as determined by SUV, is a strong index of tumour grade in bone and soft tissue sarcomas.
  • [MeSH-major] Bone Neoplasms / diagnostic imaging. Bone Neoplasms / metabolism. Fluorodeoxyglucose F18 / pharmacokinetics. Glucose / metabolism. Glucose Transporter Type 1 / metabolism. Sarcoma / diagnostic imaging. Sarcoma / metabolism

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  • (PMID = 16506050.001).
  • [ISSN] 1619-7070
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Glucose Transporter Type 1; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18; IY9XDZ35W2 / Glucose
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50. Minagawa T, Matsushita K, Shimada R, Takayama H, Hiraga R, Uehara T, Murata Y: Aggressive angiomyxoma mimicking inguinal hernia in a man. Int J Clin Oncol; 2009 Aug;14(4):365-8
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  • We report the case of a 37-year-old Japanese man who presented with a left lower abdominal mass that was initially interpreted clinically as an inguinal hernia.
  • Local excision was performed, with a preoperative diagnosis of benign soft tissue tumor.
  • Histopathological diagnosis revealed aggressive angiomyxoma (AAM), and no recurrence was observed 6 months after surgery.
  • AAM is a rare tumor which most commonly occurs in the pelvis or perineum of premenopausal women, with extremely rare cases in men.
  • The findings from previously reported cases and our case suggest that AAM should be considered in patients with an inguinal or scrotal swelling with a suspicious soft tissue tumor.
  • [MeSH-major] Hernia, Inguinal / diagnosis. Myxoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Treatment Outcome

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  • (PMID = 19705250.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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51. Lee YS, Kim JO, Park SE: Ancient schwannoma of the thigh mimicking a malignant tumour: a report of two cases, with emphasis on MRI findings. Br J Radiol; 2010 Jul;83(991):e154-7
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  • [Title] Ancient schwannoma of the thigh mimicking a malignant tumour: a report of two cases, with emphasis on MRI findings.
  • Ancient schwannomas are rare, encapsulated tumours of long duration and are benign in nature.
  • The tumour is solitary and may grow to a large size before detection of notable degenerative changes.
  • The term "ancient schwannoma" is used to describe a tumour that has undergone such changes, typified by relative loss of Antoni type A tissue, perivascular hyalinisation, calcification, cystic necrosis, haemorrhage and the presence of degenerative nuclei that may be misinterpreted as sarcomatous pleomorphism.
  • Identifying the fibrous capsule of the mass and a split fat sign using MRI is important for differentiating ancient schwannoma from other malignant tumours.
  • [MeSH-major] Neurilemmoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Muscle Neoplasms / diagnosis. Thigh

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  • (PMID = 20603402.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3473686
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52. Karwacki MW, Woźniak W: [Neurofibromatosis--an inborn genetic disorder with susceptibility to neoplasia]. Med Wieku Rozwoj; 2006 Jul-Sep;10(3 Pt 2):923-48
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  • [Title] [Neurofibromatosis--an inborn genetic disorder with susceptibility to neoplasia].
  • Both are autosomal dominant disorders with 100% penetration, variable expression and 50% rate of new (de novo) mutations.
  • The protein products of both, NF1 andNF2 genes are best known and the genes serve as tumour suppressors.
  • Mutations result in a predisposition to develop a variety of tumours of the central and peripheral nervous systems, as well as other malignancies.
  • Nf-2 is a multisystem genetic disorder associated with bilateral vestibular schwannomas, spinal cord schwannomas, meningiomas, gliomas, and juvenile cataracts with a paucity of cutaneous features, which are seen more consistently in Nf-1.
  • In contrast to Nf-1, Nf-2 is associated with significant morbidity and decreased life span and a higher incidence of CNS tumours.
  • Optic gliomas and both malignant and benign peripheral nerve sheet tumours are the most common malignancies arising in Nf-1 patients.
  • [MeSH-major] Genes, Neurofibromatosis 1. Genes, Neurofibromatosis 2. Neurofibromatoses / diagnosis. Neurofibromatoses / genetics
  • [MeSH-minor] Comorbidity. Cranial Nerve Neoplasms / diagnosis. Cranial Nerve Neoplasms / epidemiology. Cranial Nerve Neoplasms / genetics. Genetic Predisposition to Disease. Humans. Neurofibromatosis 1 / diagnosis. Neurofibromatosis 1 / genetics. Neurofibromatosis 2 / diagnosis. Neurofibromatosis 2 / genetics. Optic Nerve Diseases / diagnosis. Optic Nerve Diseases / genetics. Pigmentation Disorders / diagnosis. Pigmentation Disorders / genetics. Scoliosis / diagnosis. Scoliosis / epidemiology. Scoliosis / genetics. Skin Neoplasms / diagnosis. Skin Neoplasms / epidemiology. Skin Neoplasms / genetics. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / epidemiology. Soft Tissue Neoplasms / genetics. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / epidemiology. Spinal Cord Neoplasms / genetics


53. Hirachand S, Lakhey M, Singha AK, Devkota S, Akhter J: Fine needle aspiration (FNA) of soft tissue tumours (STT). Kathmandu Univ Med J (KUMJ); 2007 Jul-Sep;5(3):374-7
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  • [Title] Fine needle aspiration (FNA) of soft tissue tumours (STT).
  • OBJECTIVES: The cytological findings of 50 ST Ts were evaluated aiming to determine the role of FNA in diagnosis of STTs METHODS: Fifty patients with soft tissue tumours underwent FNA in the preoperative investigation during a one year period.
  • RESULTS: Forty-four cases were reported as benign, whereas 2 were malignant.
  • The malignant STTs were small round cell tumour and malignant spindle cell tumour.
  • CONCLUSION: A reliable diagnosis of STTs can be made with FNA when supported by other clinical and other diagnostic data.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Diagnosis, Differential. False Negative Reactions. Female. Humans. Male. Middle Aged. Sensitivity and Specificity

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  • (PMID = 18604057.001).
  • [ISSN] 1812-2078
  • [Journal-full-title] Kathmandu University medical journal (KUMJ)
  • [ISO-abbreviation] Kathmandu Univ Med J (KUMJ)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nepal
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54. Hasham S, Matteucci P, Stanley PR: Schwannomatosis: multiple schwannomas of the upper limb. J Hand Surg Br; 2006 Apr;31(2):182-4
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  • Schwannomas (also known as neurilemmomas) are neoplasms of the peripheral nerve sheaths.
  • They are the most common benign tumour of peripheral nerves, yet they account for only 5% of all soft tissue tumours.
  • We present an unusual case of multiple schwannomas in the upper limb so that other surgeons can share our experience and suggest the correct diagnosis when confronted with a similar case.
  • [MeSH-major] Neurilemmoma / pathology. Neurilemmoma / surgery. Peripheral Nervous System Neoplasms / pathology. Peripheral Nervous System Neoplasms / surgery

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  • (PMID = 16364515.001).
  • [ISSN] 0266-7681
  • [Journal-full-title] Journal of hand surgery (Edinburgh, Scotland)
  • [ISO-abbreviation] J Hand Surg Br
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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55. Murphy A, Williams J: Posterior interosseous nerve palsy caused by lipoma: A case report. Can J Plast Surg; 2009;17(4):e42-4
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  • Lipomas are benign soft tissue neoplasms that occur commonly in subcutaneous tissue.

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  • (PMID = 21119834.001).
  • [ISSN] 1918-1507
  • [Journal-full-title] The Canadian journal of plastic surgery = Journal canadien de chirurgie plastique
  • [ISO-abbreviation] Can J Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2827290
  • [Keywords] NOTNLM ; Forearm / Lipoma / Posterior interosseous nerve palsy
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56. Aleixo PB, Hartmann AA, Menezes IC, Meurer RT, Oliveira AM: Can MDM2 and CDK4 make the diagnosis of well differentiated/dedifferentiated liposarcoma? An immunohistochemical study on 129 soft tissue tumours. J Clin Pathol; 2009 Dec;62(12):1127-35
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  • [Title] Can MDM2 and CDK4 make the diagnosis of well differentiated/dedifferentiated liposarcoma? An immunohistochemical study on 129 soft tissue tumours.
  • METHODS: IHC for MDM2/CDK4 was carried out on a series of 129 paraffin-embedded lipomatous and non-lipomatous soft tissue tumours.
  • The cases were divided into four groups: WDLPS (n = 19), DDLPS (n = 10), benign adipocytic tumours (BAT) (n = 17), and other mesenquimal tumours (OMT) (n = 83).
  • IHC results were compared in each group and the diagnostic efficacy of the test in identifying WDLPS and DDLPS among the other soft tissue tumours was determined.
  • A percentage of tumour cell positivity was evaluated to better characterise the pattern of tumour immunostaining.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Cyclin-Dependent Kinase 4 / metabolism. Liposarcoma / diagnosis. Proto-Oncogene Proteins c-mdm2 / metabolism. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Differentiation. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Neoplasm Proteins / metabolism. Sensitivity and Specificity

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  • (PMID = 19946100.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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57. O'Dwyer HM, Keogh CF, O'Connell JX, Munk PL: A case report of synchronous osteoblastoma and fibromatosis. Br J Radiol; 2008 Mar;81(963):e68-71
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  • Osteoblastoma is a rare bone tumour that accounts for 1% of all primary bone tumours and 3% of all benign bone tumours.
  • It bears a close histological resemblance to osteoid osteoma, but it is not growth limited - usually 2 cm or greater at diagnosis.
  • The term "fibromatosis" covers a broad spectrum of benign fibrous tissue proliferations.
  • It is characterized by infiltrative growth and a tendency for recurrence; however, unlike sarcoma, it never metastasizes.
  • To our knowledge, this is the first case report in the English literature of a patient with synchronous presentation of an osteoblastoma and fibromatosis.
  • [MeSH-major] Femoral Neoplasms / pathology. Fibroma / pathology. Neoplasms, Multiple Primary / pathology. Osteoblastoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Thigh. Tomography, X-Ray Computed

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  • (PMID = 18270286.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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58. Wu CW, Chi HP, Chiang FY, Hsu YC, Chan LP, Kuo WR: Giant lipoma arising from deep lobe of the parotid gland. World J Surg Oncol; 2006;4:28
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Lipomas are common benign soft tissue neoplasms but they are found very rarely in the deep lobe of parotid gland.

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  • (PMID = 16740172.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
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  • [Publication-type] Journal Article
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59. Nigri G, Dente M, Valabrega S, Beccaria G, Aurello P, D'Angelo F, Di Marzo F, Ramacciato G: Giant inframuscular lipoma disclosed 14 years after a blunt trauma: a case report. J Med Case Rep; 2008;2:318
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  • INTRODUCTION: Lipoma is the most frequent benign tumor of the soft tissue.
  • Although the diagnosis is mostly clinical, imaging tools are useful to confirm the adipose nature of the lesion and to define its anatomic border.
  • Sometimes, lipomas may be the result of a previous trauma, such as in this patient.
  • We herein present an exceptional case of a giant post-traumatic lipoma which caused a painful compression on the right sciatic nerve.

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  • (PMID = 18826615.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2569952
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60. Ui M, Ogawa K: Subdeltoid lipoma: a case with symptoms mimicking glenohumeral instability and subacromial impingement. Orthopedics; 2010 Jun;33(6):443
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  • Lipoma is the most frequently occurring benign soft tissue tumor in the shoulder and the axillary region in middle-aged and older persons, yet few such lipoma cases have been associated with clinical symptoms.
  • A 38-year-old right-handed man presented with an enlarged feeling and a painful back-and-forth popping in his left shoulder.
  • Magnetic resonance imaging showed a homogenous tumor in the subdeltoid that was isointense relative to the subcutaneous fat and fluid collection in the hypertrophic subacromial bursa.
  • As the tumor was considered from the clinical and imaging findings to be attributable to all clinical symptoms, it was resected en bloc with a satisfactory result.
  • Histopathologically, the tumor showed typical features of a simple lipoma.
  • To our knowledge, the present case is the first of a subdeltoid intermuscular lipoma of which mechanism developing symptoms was preoperatively surmised from imaging.
  • [MeSH-major] Lipoma / diagnosis. Muscle Neoplasms / diagnosis. Shoulder Dislocation / diagnosis. Shoulder Impingement Syndrome / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Shoulder

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  • [Copyright] Copyright 2010, SLACK Incorporated.
  • (PMID = 20806760.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Sierota D, Stefanowicz J, Wierzba J, Adamkiewicz-Drozyńska E, Wybieralska-Dubaniewicz M, Kosiak W, Komasara L, Czauderna P, Izycka-Swieszewska E, Pilarska E, Birkholtz D, Stachowicz-Stencel T, Połczyńska K, Bień E, Szołkiewicz A, Stefanowicz A, Balcerska A: [Neurofibromatosis type 1 in children. Experiences of the Gdansk Paediatric Oncohaematology Centre. Preliminary results]. Med Wieku Rozwoj; 2007 Jul-Sep;11(3 Pt 2):307-12
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  • INTRODUCTION: Neurofibromatosis type 1 (NF1) is a frequent genetic disorder of autosomal-dominant pattern.
  • Patients with NF1 are predisposed to malignancies including soft tissue sarcomas and leukaemias.
  • Secondary symptoms and complications such as mental retardation (9 cases) and epilepsy (10 cases), cognitive disorders and learning disabilities (21), abnormalities in MRI examination (53), benign or malignant CNS tumours (9), scoliosis (99) were diagnosed.
  • In 5 patients malignant neoplasms occurred (3.4%) including: RMS--2 cases, Triton tumour--1 case, MPNST--1 case.
  • [MeSH-major] Neurofibromatosis 1 / diagnosis. Neurofibromatosis 1 / therapy. Physical Examination


62. Lim KJ, Moon JH, Yoon DY, Cha JH, Lee IJ, Min SJ: Angiomyofibroblastoma arising from the posterior perivesical space: a case report with MR findings. Korean J Radiol; 2008 Jul-Aug;9(4):382-5
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  • Angiomyofibroblastoma is a rare benign soft tissue neoplasm that predominantly occurs in the genital region of middle-aged women.
  • [MeSH-major] Angiofibroma / diagnosis. Angiomyoma / diagnosis. Magnetic Resonance Imaging. Vaginal Neoplasms / diagnosis

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  • (PMID = 18682679.001).
  • [ISSN] 1229-6929
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2627271
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63. Bjerkehagen B, Myklebost O: [Molecular genetics in the diagnosis of bone and soft tissue tumours]. Tidsskr Nor Laegeforen; 2005 Dec 1;125(23):3286-9
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  • [Title] [Molecular genetics in the diagnosis of bone and soft tissue tumours].
  • INTRODUCTION: Bone and soft tissue tumours are relatively rare; they make up about 1% of all new cancer cases, but around 10% among children and adolescents.
  • At the slightest suspicion of malignancy, no biopsy should be performed locally; the patient should be referred to a hospital with experience with this tumour type.
  • Specific chromosomal aberrations have been described in several benign and malignant tumours; sarcomas may be divided into two subgroups based on cytogenetics, one with near-diploid karyotype and few chromosomal changes, but with specific translocations and one with complex karyotypes and multiple cytogenetic aberrations.
  • Gastrointestinal stromal tumour (GIST) is a tumour in the gastrointestinal tract where immunohistochemical analysis of the c-kit receptor and molecular diagnosis of mutations in the corresponding gene is important, as targeted therapy towards mutated versions of this receptor is available.
  • [MeSH-major] Bone Neoplasms / diagnosis. Genetic Techniques. Molecular Diagnostic Techniques. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Chromosome Aberrations. Gastrointestinal Stromal Tumors / diagnosis. Gastrointestinal Stromal Tumors / genetics. Genetic Predisposition to Disease. Humans. Mutation. Prognosis

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  • (PMID = 16327856.001).
  • [ISSN] 0807-7096
  • [Journal-full-title] Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
  • [ISO-abbreviation] Tidsskr. Nor. Laegeforen.
  • [Language] nor
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Norway
  • [Number-of-references] 22
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64. Shapeero LG, De Visschere PJ, Verstraete KL, Poffyn B, Forsyth R, Sys G, Uyttendaele D: Post-treatment complications of soft tissue tumours. Eur J Radiol; 2009 Feb;69(2):209-21
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  • [Title] Post-treatment complications of soft tissue tumours.
  • PURPOSE: To identify local and distant complications of patients with soft tissue tumours and evaluate their relationships to types of therapy.
  • METHODS AND MATERIALS: Fifty-one patients (29 males and 22 females, ages 14-80 years) with 34 malignant and 17 benign soft tissue tumours were evaluated for local and distant complications after resection or amputation only (26 patients) or after the addition of radiotherapy (25 patients: 17 patients had external beam therapy, 7 patients had external beam therapy and brachytherapy, and one patient had extracorporeal irradiation and reimplantation).
  • Duration of follow-up averaged 3.75 years for malignant tumours and 2.79 years for benign tumours.
  • Metastases from soft tissue sarcomas, most commonly to lung (nine patients) and to bone and muscle (five patients), showed no specific relationship to type of therapy.
  • DCE-MRI differentiated rapidly enhancing soft tissue recurrences (11 patients) and residual tumours (6 patients) from slowly enhancing muscle inflammation, and non-enhancing fibrosis and seromas that usually did not enhance.
  • Irrespective of the type of treatment, inflammatory changes in muscle and subcutaneous and cutaneous tissue and the majority of seromas were evident at the first follow-up study.
  • Inflammatory changes in muscle and cutaneous and subcutaneous tissue after resection alone disappeared by the second follow-up study, whereas these changes after radiotherapy resolved months to years after treatment.
  • Except for one patient with aggressive fibromatosis, bone and nerve complications occurred in patients with soft tissue malignancy.
  • In nerve entrapment, DCE-MRI demonstrated the rapidly enhancing recurrent tumour or non-enhancing fibrosis surrounding the slowly enhancing nerve.
  • CONCLUSION: This study suggests a possible relationship between types of treatment of soft tissue tumours and subsequent complications.
  • Diligent follow-up of patients with soft tissue tumours with recognition of these complications and their differentiation from recurrent or residual tumour can help guide clinical care and may negate the need for surgery when benign disease is defined.
  • [MeSH-major] Postoperative Complications / diagnosis. Postoperative Complications / etiology. Radiation Injuries / diagnosis. Radiation Injuries / etiology. Radiotherapy, Conformal / adverse effects. Soft Tissue Neoplasms / complications. Soft Tissue Neoplasms / therapy

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  • (PMID = 19101106.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] Ireland
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65. Jani DR, Chawda J, Sundaragiri SK, Parmar G: Mucocele--a study of 36 cases. Indian J Dent Res; 2010 Jul-Sep;21(3):337-40
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  • BACKGROUND: Mucocele is one of the most common benign soft tissue tumor present in the oral cavity.
  • The clinical data were recorded and histopathologic diagnosis was made.
  • RESULTS: A diagnosis of mucocele was established in 36 cases with male-to-female ratio of 1.77:1.

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  • (PMID = 20930340.001).
  • [ISSN] 1998-3603
  • [Journal-full-title] Indian journal of dental research : official publication of Indian Society for Dental Research
  • [ISO-abbreviation] Indian J Dent Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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66. Wada T, Kawai A, Ihara K, Sasaki M, Sonoda T, Imaeda T, Yamashita T: Construct validity of the Enneking score for measuring function in patients with malignant or aggressive benign tumours of the upper limb. J Bone Joint Surg Br; 2007 May;89(5):659-63
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  • [Title] Construct validity of the Enneking score for measuring function in patients with malignant or aggressive benign tumours of the upper limb.
  • We evaluated the construct validity of the Musculoskeletal Tumour Society rating scale (Enneking score) as a functional measure for patients with sarcoma involving the upper limb.
  • We compared the Enneking score by examining the correlation between two patient-derived outcome measures, the Disability of the Arm, Shoulder, and Hand (DASH) questionnaire and the Medical Outcomes Study Short Form-36 (SF-36) as indicators of functional status in 40 patients with malignant or aggressive benign bone and soft-tissue tumours of the upper limb who had undergone surgical treatment.
  • Despite being a measure from the surgeon's perspective, the Enneking score was shown to be a valid indicator of physical disability in patients with malignant or aggressive benign tumours of the upper limb and reflected their opinion.
  • [MeSH-major] Bone Neoplasms / physiopathology. Sarcoma / physiopathology. Severity of Illness Index. Soft Tissue Neoplasms / physiopathology. Upper Extremity / physiopathology

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  • (PMID = 17540754.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] England
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67. Miettinen M, Fetsch JF: Evaluation of biological potential of smooth muscle tumours. Histopathology; 2006 Jan;48(1):97-105
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  • Smooth muscle tumours (SMTs) have been traditionally divided into benign leiomyomas (LM) and malignant leiomyosarcomas (LMS) based on cytological atypia, mitotic activity and other criteria.
  • For most non-hormonally influenced SMTs, the presence of significant atypia plus mitotic activity equates with a diagnosis of LMS.
  • However, not all tumours classified as LMSs have a similar prognosis, as a number of other factors, including tumour size, depth, grade and resectability, affect outcome.
  • Angioleiomyoma is the most common SMT of peripheral soft tissues, but deep peripheral LMs are distinctly rare and should be approached with caution.
  • Hormonally influenced oestrogen- and progesterone receptor-positive uterine and extrauterine SMTs in women have unique criteria, including the allowance of higher mitotic activity for the benign LM designation.
  • This review summarizes the current knowledge, guidelines, prognostic data and controversies for the classification of SMTs of soft tissue and most visceral sites.
  • [MeSH-major] Muscle, Smooth / pathology. Neoplasms, Muscle Tissue / pathology
  • [MeSH-minor] Actins / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Leiomyoma / metabolism. Leiomyoma / pathology. Leiomyosarcoma / metabolism. Leiomyosarcoma / pathology. Mitotic Index. Prognosis

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  • (PMID = 16359541.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Actins
  • [Number-of-references] 43
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68. Sakai H, Minemura T, Ito N, Miyazawa H, Kurashina K: Isolated osteochondroma near the mandibular angle. Int J Oral Maxillofac Surg; 2007 Mar;36(3):274-5
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  • A benign tumour of osseous and cartilaginous origins, osteochondroma generally develops in osseous tissue and is frequently found near the end of long bones.
  • This is a report on a rare case of osteochondroma in soft tissue near the mandibular angle without pedicle to the bone.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Osteochondroma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 17052896.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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69. Poprach A, Michalová E, Pavlík T, Lakomy R, Vyskocil J, Nemeccek R, Zaloudík J, Vyzula R, Kocák I, Kocáková I: [Actual state of ex vivo chemoresistance testing of malignant tumors in Masaryk Memorial Cancer Institute Brno]. Klin Onkol; 2008;21(3):116-21
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  • (1) metastatic malignant melanoma, (2) soft tissue sarcoma (STS), either primary or recurrent/metastic, (3) primary or metastatic renal cancer, (4) recurrent ovarian cancer and (5) other diagnosis "on clinician's request".
  • Sensitivity to certain chemotherapy agent observed ex vivo does not necessarily mean that the cancer would also be sensitive to the same agent in vivo, however, ex vivo resistance with following in vivo sensitivity of the tumour has not been observed to date.
  • The cultivation of malignant cells is very uncertain in solid tumours, which consist of several malignant cell multiclones (benign/stromal cells may outgrow malignant cells).
  • [MeSH-minor] Drug Resistance, Neoplasm. Female. Humans. Kidney Neoplasms / drug therapy. Melanoma / drug therapy. Ovarian Neoplasms / drug therapy. Sarcoma / drug therapy

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  • (PMID = 19097421.001).
  • [ISSN] 0862-495X
  • [Journal-full-title] Klinická onkologie : casopis Ceské a Slovenské onkologické spolecnosti
  • [ISO-abbreviation] Klin Onkol
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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70. Nakashima K, Yamada N, Yoshida Y, Yamamoto O: Solitary sclerotic neurofibroma of the skin. Am J Dermatopathol; 2008 Jun;30(3):278-80
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  • Solitary neurofibroma of the skin is a benign soft tissue tumor.
  • Clinically, it is a flesh-colored, slow-growing, soft tumor and sometimes shows diverse histological patterns.
  • Our findings suggest that mast cells may have played a role in the formation of the sclerotic regions of the current tumor.
  • [MeSH-major] Neurofibroma / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Aged. Collagen / metabolism. Dermis / pathology. Female. Humans. Mast Cells / pathology. Sclerosis / metabolism. Sclerosis / pathology. Subcutaneous Tissue / pathology

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  • (PMID = 18496433.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-34-5 / Collagen
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71. Sari A, Tunakan M, Bolat B, Cakmakçi H, Ozer E: Lipofibromatosis in a two-year-old girl: a case report. Turk J Pediatr; 2007 Jul-Sep;49(3):319-21
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  • Lipofibromatosis is a recently described rare benign soft tissue tumor of childhood.
  • We report a case of a lipofibromatosis in a two-year-old girl with a painless mass on the plantar aspect of her right foot who developed local recurrence eight months after surgery.
  • The tumor has a high rate of non-destructive recurrence, but there is no metastatic potential.
  • [MeSH-major] Fibroma / pathology. Neoplasm Recurrence, Local / surgery

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  • (PMID = 17990590.001).
  • [ISSN] 0041-4301
  • [Journal-full-title] The Turkish journal of pediatrics
  • [ISO-abbreviation] Turk. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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72. Revet I, Huizenga G, Chan A, Koster J, Volckmann R, van Sluis P, Øra I, Versteeg R, Geerts D: The MSX1 homeobox transcription factor is a downstream target of PHOX2B and activates the Delta-Notch pathway in neuroblastoma. Exp Cell Res; 2008 Feb 15;314(4):707-19
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  • Neuroblastoma is an embryonal tumour of the peripheral sympathetic nervous system (SNS).
  • Inducible expression of MSX1 in SJNB-8 caused inhibition of both cell proliferation and colony formation in soft agar.
  • These experiments describe for the first time regulation of the Delta-Notch pathway by MSX1, and connect these genes to the PHOX2B oncogene, indicative of a role in neuroblastoma biology.
  • Affymetrix micro-array analysis of a neuroblastic tumour series consisting of neuroblastomas and the more benign ganglioneuromas showed that MSX1, NOTCH3 and HEY1 are more highly expressed in ganglioneuromas.
  • [MeSH-minor] Basic Helix-Loop-Helix Transcription Factors / biosynthesis. Basic Helix-Loop-Helix Transcription Factors / genetics. Basic Helix-Loop-Helix Transcription Factors / metabolism. Cell Cycle Proteins / genetics. Cell Cycle Proteins / metabolism. Cell Line, Tumor. Cell Proliferation. Down-Regulation. Gene Expression Regulation, Neoplastic. Humans. Intercellular Signaling Peptides and Proteins / genetics. Intercellular Signaling Peptides and Proteins / metabolism. Intracellular Signaling Peptides and Proteins. Nerve Tissue Proteins / biosynthesis. Nerve Tissue Proteins / genetics. Signal Transduction. Tumor Stem Cell Assay

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  • (PMID = 18201699.001).
  • [ISSN] 0014-4827
  • [Journal-full-title] Experimental cell research
  • [ISO-abbreviation] Exp. Cell Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Cell Cycle Proteins; 0 / DLK1 protein, human; 0 / HEY1 protein, human; 0 / Homeodomain Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / MSX1 Transcription Factor; 0 / Membrane Proteins; 0 / NBPhox protein; 0 / NOTCH3 protein, human; 0 / Nerve Tissue Proteins; 0 / Receptors, Notch; 0 / Transcription Factors; 0 / delta protein; 169238-82-8 / NeuroD protein
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73. Ech-Charif S, Aubert S, Buob D, Verhulst P, Blomme V, Migaud H, Leroy X: [Giant cell tumor of soft tissues. Report of two cases]. Ann Pathol; 2006 Feb;26(1):26-9
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  • [Title] [Giant cell tumor of soft tissues. Report of two cases].
  • [Transliterated title] Tumeur à cellules géantes des tissus mous.
  • We report two cases of giant-cell tumour of soft tissue (TCG-TM).
  • The first case occurred in a 26-year-old woman presenting with a subcutaneous tumour of the left leg.
  • Pathological study revealed a tumour comparable to benign giant cell tumour of bone.
  • The patient is well without recurrence 10 months after the diagnosis.
  • Microscopically, the tumour was composed of sheets of mononuclear and multinucleated cells.
  • Mononuclear cells presented severe atypia and a high mitotic activity.
  • TCG-TMs are uncommon and represent a distinct entity whose clinical behaviour and histological features are similar to giant-cell tumour of bone.
  • The differential diagnosis includes other tumours rich in osteoclast-like cells.
  • [MeSH-major] Giant Cell Tumors / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Bone Neoplasms / pathology. Female. Giant Cells / pathology. Humans. Leukocytes, Mononuclear / pathology. Male. Middle Aged

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  • (PMID = 16841007.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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74. Tytherleigh MG, Birtle AJ, Cohen CE, Glynne-Jones R, Livingstone J, Gilbert J: Combined surgery and chemoradiation as a treatment for the Buschke-Löwenstein tumour. Surgeon; 2006 Dec;4(6):378-83
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  • [Title] Combined surgery and chemoradiation as a treatment for the Buschke-Löwenstein tumour.
  • BACKGROUND: The Buschke-Löwenstein tumour (BLT) or giant condyloma acuminata is a rare disease which affects the anogenital region.
  • Although histologically benign, it behaves in a malignant fashion, infiltrating the surrounding tissues.
  • The morbidity and mortality from this tumour is high, as is the risk of recurrence following treatment.
  • It lies on the continuum between the benign condylomata acuminata and squamous cell carcinoma.
  • CONCLUSION: Pre-operative chemoradiation has proved to be useful in management for histologically proven benign BLT
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Condylomata Acuminata / therapy. Neoadjuvant Therapy. Perineum / pathology. Perineum / surgery. Soft Tissue Neoplasms / therapy
  • [MeSH-minor] Abdominal Neoplasms / secondary. Abdominal Neoplasms / therapy. Adult. Anus Neoplasms / secondary. Anus Neoplasms / therapy. Carcinoma in Situ / pathology. Carcinoma in Situ / therapy. Carcinoma, Squamous Cell / therapy. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Fatal Outcome. Fluorouracil / administration & dosage. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Radiotherapy, Adjuvant. Rectal Neoplasms / secondary. Rectal Neoplasms / therapy

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  • (PMID = 17152203.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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75. Arora R, Gupta R, Sharma A, Dinda AK: A rare case of low-grade myofibroblastic sarcoma of the femur in a 38-year-old woman: a case report. J Med Case Rep; 2010;4:121
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  • INTRODUCTION: Primary myofibroblastic sarcoma of the bone is a rare spindle cell tumour with, to the best of our knowledge, only eight cases reported in the available English language literature.
  • The disease's rarity and its low-grade features make an accurate diagnosis difficult in most cases.
  • The differential diagnoses of this unusual tumour include various benign entities as well as other sarcomas.
  • Due to the difference in prognosis, a precise pathologic diagnosis is essential, which requires a combination of thorough morphologic examination, immunohistochemistry and electron microscopy wherever available.
  • CASE PRESENTATION: We report the case of a 38-year-old Indian woman with a lytic lesion in her left femur.
  • The tumour was associated with cortical destruction and soft tissue extension.
  • A biopsy from the soft tissue component showed features suggestive of a low-grade malignant mesenchymal tumour.
  • Excision of the tumour was performed and histopathological examination showed a low-grade spindle cell sarcoma with collagenous stroma.
  • A final diagnosis of low-grade myofibroblastic sarcoma of the left femur was thus rendered.
  • Its diagnosis requires ancillary techniques like immunohistochemistry and electron microscopy.

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  • (PMID = 20426857.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2873452
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76. Sbai MA, Hamdi MF, Aloui I, Zalouni I, Tabib M: [Soft tissue chondroma of the thumb. A case report]. Tunis Med; 2010 Oct;88(10):750-2
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  • [Title] [Soft tissue chondroma of the thumb. A case report].
  • [Transliterated title] Le chondrome des parties molles du pouce. A propos d'un cas.
  • BACKGROUND: Soft-tissue chondroma is a rare and benign cartilaginous tumour often localised in the extremities.
  • CASE REPORT: 43 year-old man presented with soft tissue tumour of the left thumb for about 4 years without any symptoms.
  • Surgery resection of the tumour was complete and easy.
  • Histological examination confirmed the diagnosis of soft-tissue chondroma.
  • CONCLUSION: Soft tissue chondroma is not a diagnosis evoked when we have a soft tissue tumor of the hand.
  • Diagnosis is confirmed by pathology which should eliminate a low grade chondrosarcoma.
  • [MeSH-major] Chondroma / diagnosis. Soft Tissue Neoplasms / diagnosis. Thumb

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  • (PMID = 20890825.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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77. Jakab C, Rusvai M, Biró N, Szabó Z, Gálfi P, Kulka J: Claudin-5-positive angioleiomyoma in the uterus of a degu (Octodon degus ). Acta Vet Hung; 2010 Sep;58(3):331-40
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  • [Title] Claudin-5-positive angioleiomyoma in the uterus of a degu (Octodon degus ).
  • The histopathological diagnosis of this soft tissue mass was primary benign cavernous angioleiomyoma of the uterus.
  • During immunohistochemical analysis the neoplastic endothelial cells of this mixed mesenchymal tumour showed strong membrane positivity for the endothelial marker claudin-5 but were negative for CD31 (another endothelial marker).
  • The endothelial cells of the internal positive control tissues such as intact peritumoural vessels were positive for claudin-5 but negative for the CD31 endothelial marker.
  • As it has been described also in other species, it seems that claudin-5 is a better endothelial marker than CD31 for the detection of normal and neoplastic endothelial cells in different tissues of degus.
  • [MeSH-major] Angiomyoma / veterinary. Biomarkers, Tumor / metabolism. Membrane Proteins / metabolism. Octodon. Rodent Diseases / pathology. Uterine Neoplasms / veterinary

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  • (PMID = 20713324.001).
  • [ISSN] 0236-6290
  • [Journal-full-title] Acta veterinaria Hungarica
  • [ISO-abbreviation] Acta Vet. Hung.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Biomarkers, Tumor; 0 / Membrane Proteins
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78. Schmidt JM, North SM, Freeman KP, Ramiro-Ibañez F: Feline paediatric oncology: retrospective assessment of 233 tumours from cats up to one year (1993 to 2008). J Small Anim Pract; 2010 Jun;51(6):306-11
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  • OBJECTIVES: To determine which types of tumour occur in cats up to the age of 12 months based on biopsies submitted to Idexx Laboratories, Wetherby, UK.
  • Tumours were categorised as haematopoietic (n=73, 31%), malignant epithelial (n=44; 19%), malignant mesenchymal (n=38; 16%), benign epithelial (n=37; 16%), benign mesenchymal (n=30, 13%) and miscellaneous (n=11; 5%).
  • The most frequent tumours were lymphoma (n=51; 22%), soft-tissue sarcoma (n=34; 15%), mast cell tumour (n=22; 9%) and squamous cell carcinoma (n=16; 7%).
  • The most common tumour site was the skin and soft tissues (41% of tumours).
  • In all, 164 neoplasms (70%) were malignant or had malignant potential.
  • [MeSH-major] Cat Diseases / pathology. Neoplasms / pathology

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  • (PMID = 20492453.001).
  • [ISSN] 1748-5827
  • [Journal-full-title] The Journal of small animal practice
  • [ISO-abbreviation] J Small Anim Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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79. Zieker D, Königsrainer I, Miller S, Vogel U, Sotlar K, Steurer W, Königsrainer A, Lehmann TG: Simultaneous adrenal and extra-adrenal myelolipoma - an uncommon incident: case report and review of the literature. World J Surg Oncol; 2008;6:72
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  • BACKGROUND: Extra-adrenal myelolipomas are rare benign tumours.
  • Other soft tissue tumours such as well-differentiated liposarcomas appear morphological almost identical.
  • CASE PRESENTATION: We report a very seldom case of a simultaneous myelolipoma of the adrenal gland in association with an extra-adrenal myelolipoma in an 75-year-old man.
  • With a review of the literature we describe and discuss the aetiology, differential diagnosis and treatment of patients with respect to adrenal and extra-adrenal lesions.
  • CONCLUSION: The appearance of a simultaneous adrenal and extra-adrenal myelolipoma is a rare incident.
  • We conclude that such lesions should be considered in the differential diagnosis of a fat-containing tumour in the retroperitoneal tissue/compartment.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Muscle Neoplasms / diagnosis. Myelolipoma / diagnosis. Retroperitoneal Neoplasms / diagnosis

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  • (PMID = 18601731.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 22
  • [Other-IDs] NLM/ PMC2474838
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80. Rohilla S, Yadav RK, Dhaulakhandi DB: Lipoma of Guyon's canal causing ulnar neuropathy. J Orthop Traumatol; 2009 Jun;10(2):101-3
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  • Lipoma is a benign soft tissue tumor which rarely causes neuropathy.

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  • [ISSN] 1590-9921
  • [Journal-full-title] Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology
  • [ISO-abbreviation] J Orthop Traumatol
  • [Language] eng
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81. Athwal GS, Bueno RA, Bansal M, Mintz DN, Athanasian EA: Intra-articular fibroma of tendon sheath involving the scapholunate and radiocarpal joints. Skeletal Radiol; 2006 Aug;35(8):599-602
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  • Fibroma of tendon sheath is an uncommon benign soft tissue tumor with a predilection for the hand.
  • Magnetic resonance imaging demonstrated a heterogeneous and lobulated mass with nonspecific signal characteristics closely associated with the scapholunate interval and the volar wrist soft tissues.
  • The tumor is discussed and the relevant literature is reviewed.
  • [MeSH-major] Fibroma / pathology. Soft Tissue Neoplasms / pathology. Wrist Joint / pathology

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  • (PMID = 16283174.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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82. Thway K: Pathology of soft tissue sarcomas. Clin Oncol (R Coll Radiol); 2009 Nov;21(9):695-705
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  • [Title] Pathology of soft tissue sarcomas.
  • Sarcomas are a rare, complex group of childhood and adult neoplasms with differentiation towards mesenchymal tissue, which may arise almost anywhere in the body.
  • Correct histopathological diagnosis is therefore crucial, but there is overlap between histological patterns of malignant tumours, between benign and malignant lesions, and with non-mesenchymal tumours.
  • Immunohistochemistry and molecular genetic techniques, the latter to detect tumour-specific alterations, add significantly to histological interpretation, but several groups of tumours still lack reliable immunohistochemical markers or reproducible genetic changes.
  • The classification of sarcomas is incomplete and continues to evolve, and although the biology of many remains relatively poorly understood, our increasing insight into molecular events occurring in these tumours is certain to aid future diagnosis and therapy.
  • This paper aims to give a broad overview of several of the main soft tissue sarcomas from a clinicopathological perspective, discussing laboratory diagnosis and the use and limitations of ancillary investigations, including recent developments in molecular diagnosis.
  • [MeSH-major] Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Gene Expression Profiling / methods. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry / methods. Mutation. Oligonucleotide Array Sequence Analysis / methods

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  • (PMID = 19734027.001).
  • [ISSN] 1433-2981
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 78
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83. Gartner L, Pearce CJ, Saifuddin A: The role of the plain radiograph in the characterisation of soft tissue tumours. Skeletal Radiol; 2009 Jun;38(6):549-58
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  • [Title] The role of the plain radiograph in the characterisation of soft tissue tumours.
  • Whilst we do not advocate that this is the only investigation to be employed in the evaluation of such patients, a working knowledge of the variety of abnormal findings that can present in the soft tissues on radiographs remains useful.
  • We reviewed the radiographic findings of soft tissue masses from a prospectively compiled database of all such lesions presenting to a specialist orthopaedic oncology service over the past 8 years.
  • Of the cohort of 1,058 individuals with a proven soft tissue tumour, 454 had had a radiograph taken of the affected area.
  • The most common findings were a visible soft tissue mass (n = 141), the presence of calcification (n = 76), fat (n = 32) and evidence of bone involvement (n = 62).
  • These findings were present in both benign and malignant tumours.
  • This review article describes the incidence and diagnostic relevance of these plain film findings for suspected soft tissue tumours.
  • [MeSH-major] Radiographic Image Enhancement / methods. Soft Tissue Neoplasms / diagnostic imaging

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  • (PMID = 18566812.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 43
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84. Rau T, Soeder S, Olk A, Aigner T: Parosteal lipoma of the thigh with cartilaginous and osseous differentiation: an osteochondrolipoma. Ann Diagn Pathol; 2006 Oct;10(5):279-82
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  • Lipomas are very common benign soft tissue neoplasms.
  • Mature cartilage and bone arising in a lipoma is a rare event and is mostly associated with a parosteal localization of the neoplasm.
  • The occurrence of at least 4 distinct directions of mesenchymal cell differentiation within a benign neoplasia underlines the concept of multilineage differentiation of pluripotent mesenchymal stem cells.
  • Such a multidirectional potential was recently well established in vitro in stem cells present in adult adipocytic tissue.
  • [MeSH-major] Bone and Bones / pathology. Cartilage / pathology. Lipoma / pathology. Periosteum / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adipocytes / pathology. Aged. Cell Differentiation. Cell Transformation, Neoplastic / pathology. Diagnosis, Differential. Humans. Male. Mesenchymal Stromal Cells / pathology. Ossification, Heterotopic / pathology. Thigh

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  • (PMID = 16979520.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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85. Dimitrakopoulos I, Lasaridis N, Asimaki A: Primary malignant peripheral nerve sheath tumour in the temporalis muscle. J Craniomaxillofac Surg; 2008 Jul;36(5):300-3
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  • [Title] Primary malignant peripheral nerve sheath tumour in the temporalis muscle.
  • INTRODUCTION: Primary malignant neoplasms of nerve sheath origin are rare, highly aggressive tumours that account for no more than 5% of all soft tissue sarcomas.
  • In the head and neck where the great majority of peripheral nerve neoplasms are benign, as in the rest of the body, malignant peripheral nerve sheath tumours (MPNSTs) are unusual lesions.
  • PATIENT: A case of a large MPNST is reported, which originated in the left temporalis muscle of a 74-year-old man who did not suffer from von Recklinghausen's disease.
  • DISCUSSION: The clinicopathologic properties of this neoplasm have been widely discussed and the emphasis is on the need for its early identification since the tumour's non-specific symptoms may result in delayed diagnosis and treatment.
  • The rarity of the tumour along with its clinical appearance and the vague symptoms may result in delayed referral and thus the tumour being quite large when diagnosed.
  • [MeSH-major] Muscle Neoplasms / pathology. Nerve Sheath Neoplasms / pathology. Temporal Muscle / pathology
  • [MeSH-minor] Aged. Fatal Outcome. Humans. Male. Neoplasm Recurrence, Local / surgery

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  • (PMID = 18367405.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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86. Dias PF, Pedro Rde L, Janine ME, Maia LC: Congenital epulis: an unusual case of spontaneous regression. Gen Dent; 2008 Jul-Aug;56(5):e25-7
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  • Congenital epulis is a rare benign neoplasm of the soft tissues.
  • This article reports an unusual case of a girl whose dentist diagnosed congenital epulis when she was 16 months old; the epulis disappeared completely three months later.
  • [MeSH-major] Gingival Neoplasms / congenital. Neoplasm Regression, Spontaneous / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Follow-Up Studies. Humans. Infant

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  • (PMID = 21444268.001).
  • [ISSN] 0363-6771
  • [Journal-full-title] General dentistry
  • [ISO-abbreviation] Gen Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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87. Pichi B, Manciocco V, Marchesi P, Pellini R, Ruscito P, Vidiri A, Covello R, Spriano G: Rhabdomyoma of the parapharyngeal space presenting with dysphagia. Dysphagia; 2008 Jun;23(2):202-4
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  • Rhabdomyoma is an exceedingly rare soft tissue benign tumor of skeletal muscle origin classified into cardiac and extracardiac types based on location.
  • Adult rhabdomyomas are rare, but morphologically characteristic, benign mesenchymal tumors with mature skeletal muscle differentiation that in 90% of cases arise in the head and neck region, mainly in the mucosa of the oropharynx, nasopharynx, and larynx, from the branchial musculature of third and fourth branchial arches.
  • [MeSH-major] Deglutition Disorders / etiology. Oropharyngeal Neoplasms / complications. Oropharyngeal Neoplasms / pathology. Rhabdomyoma / complications. Rhabdomyoma / pathology

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  • (PMID = 17965913.001).
  • [ISSN] 0179-051X
  • [Journal-full-title] Dysphagia
  • [ISO-abbreviation] Dysphagia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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88. Chadha M, Singh AP: Unusual knee swelling: a diagnostic dilemma. Arch Orthop Trauma Surg; 2007 Sep;127(7):593-6
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  • Haemangioma is a common benign soft tissue tumour.
  • An intramuscular haemangioma can be confused with other soft tissue swellings including abscess.
  • [MeSH-major] Hemangioma, Cavernous / diagnosis. Muscle Neoplasms / diagnosis
  • [MeSH-minor] Child. Diagnosis, Differential. Edema / diagnosis. Humans. Knee. Male

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  • (PMID = 17165037.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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89. Forsyth SF, Thompson KG, French AF, Halsey TR: Possible parachordoma in a dog. N Z Vet J; 2009 Oct;57(5):299-302
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  • CASE HISTORY: A 15-mm diameter mass developed in the S/C tissue overlying the right lateral gluteal muscle of a 6(1/2)-year-old female Flat-coated Retriever.
  • PATHOLOGICAL FINDINGS: Cytological preparations following aspiration of the mass were highly cellular and consisted of a population of large polygonal cells containing single to multiple nuclei, large prominent nucleoli, and intracytoplasmic vacuoles.
  • Histologically, the neoplasm consisted of similar large cells surrounded by thick fibrous connective tissue trabeculae.
  • DIAGNOSIS: The clinical, gross, histological and immunohistochemical findings are similar to those reported for parachordomas in humans.
  • CLINICAL RELEVANCE: This is the first reported case of a possible parachordoma in a dog, a benign tumour with cytological features of malignancy.
  • [MeSH-major] Dog Diseases / pathology. Neoplasms / veterinary. Soft Tissue Neoplasms / pathology

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  • (PMID = 19802045.001).
  • [ISSN] 0048-0169
  • [Journal-full-title] New Zealand veterinary journal
  • [ISO-abbreviation] N Z Vet J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] New Zealand
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90. Thway K, Fisher C: Histopathological diagnostic discrepancies in soft tissue tumours referred to a specialist centre. Sarcoma; 2009;2009:741975
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histopathological diagnostic discrepancies in soft tissue tumours referred to a specialist centre.
  • Aims. A study was performed to determine areas of diagnostic discrepancy in the reporting of cases of soft tissue tumours referred to a specialist sarcoma unit.
  • We compared the sarcoma unit's histopathology reports with referring reports on 349 specimens from 277 patients with suspected or proven soft tissue tumours in a one-year period.
  • Benign/malignant discordances accounted for only 5% of all discrepancies (5 cases).
  • The most common discrepancies occurred in tumour classification, including diagnosis of gastrointestinal stromal tumour and leiomyosarcoma and the subtyping of spindle cell sarcomas, as well as in tumour grading that could conceivably lead to changes in clinical management.
  • Major diagnostic discrepancies leading to management change occurred in a relatively select range of tumour groups, and almost all discrepancies occurred due to differences in tumour interpretation between general or nonsoft tissue pathologists, and pathologists at the specialist unit.
  • The findings support guidelines by the National Institute for Health and Clinical Excellence that diagnostic review of soft tissue tumours should be performed by specialist soft tissue pathologists.

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  • (PMID = 19503800.001).
  • [ISSN] 1357-714X
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2688650
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91. Paraskeva P, Katsaronis P, Spartalis ED, Lazaris AC, Gakiopoulou H, Mallis P, Tomos P: Giant liposarcoma of the back with 4 types of histopathology: a case report. Cases J; 2009;2:9339
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The incidence of soft tissue tumours, both malignant and benign, is very common.
  • An 87-year-old Greek man was treated in our Department for a huge tumour on his back, under local anaesthesia.
  • The pathology report of the specimen referred 4 types of neoplasia.

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  • [Cites] Gen Thorac Cardiovasc Surg. 2009 Mar;57(3):159-61 [19280315.001]
  • [Cites] Cancer. 2009 Mar 1;115(5):1081-90 [19156920.001]
  • (PMID = 20084188.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2807439
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92. Pellegrino M, Vadrucci S, Tinelli A: [Angiomyofibroblastoma of the vulva: a rare but distinct entity. Case report and literature review]. Pathologica; 2007 Dec;99(6):438-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Angiomyofibroblastoma is a benign vulvar tumour involving soft tissue that is characterized by alternating hypocellular and hypercellular areas of spindle stromal cells, admixed and aggregated around blood vessels.
  • It is important to recognize this entity as it shows benign behaviour with respect to other mesenchymal tumours of the vagina, which have a more aggressive behaviour.
  • [MeSH-major] Angiofibroma / pathology. Angiomyoma / pathology. Hemangioblastoma / pathology. Neoplasms, Second Primary / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, CD34 / analysis. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor. Breast Neoplasms / drug therapy. Breast Neoplasms / surgery. Combined Modality Therapy. Female. Humans. Lymphoma, Large B-Cell, Diffuse / drug therapy. Lymphoma, Large B-Cell, Diffuse / surgery. Neoplasm Proteins / analysis. Receptors, Estrogen / analysis

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  • (PMID = 18416337.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Receptors, Estrogen
  • [Number-of-references] 7
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93. Moretti VM, de la Cruz M, Lackman RD, Fox EJ: Fibroma of tendon sheath in the knee: a report of three cases and literature review. Knee; 2010 Aug;17(4):306-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Fibroma of tendon sheath (FTS) is a rare and benign soft-tissue tumor.
  • Physical exam for knee FTS commonly reveals painful range of motion (50%), decreased range of motion (42%), and a palpable non-tender mass (33%).
  • MRI of FTS usually reveals a well-defined soft-tissue mass, with low signal on T1, variable signal on T2, and variable enhancement.
  • Histologically, the tumors are composed of a dense fibrocollagenous stroma with scattered spindle-shaped fibroblasts and narrow slit-like vascular spaces.
  • Despite its rarity, this lesion should be included in the differential diagnosis of a knee mass on physical exam or imaging, especially if it is painful, benign appearing, and present in a middle-aged male.
  • [MeSH-major] Fibroma / pathology. Knee Joint / pathology. Soft Tissue Neoplasms / pathology. Tendons / pathology

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  • [Copyright] Copyright 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20347314.001).
  • [ISSN] 1873-5800
  • [Journal-full-title] The Knee
  • [ISO-abbreviation] Knee
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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94. Nuruddin M, Osmani M, Mudhar HS, Fernando M: Orbital lipofibromatosis in a child: a case report. Orbit; 2010 Dec;29(6):360-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Lipofibromatosis is a rare, benign, soft tissue tumor that typically involves extremities particularly in children.
  • CASE REPORT: An 8-year-old girl presented with a history of a gradually expanding mass in the superotemporal quadrant of the left orbit over several years.
  • Orbital imaging showed a soft tissue mass superolateral to the globe with possible infiltration into the lacrimal gland and lateral rectus muscle.
  • Histopathological examination revealed that the lesion consisted of adipose tissue with fibroblastic elements, being consistent with a diagnosis of lipofibromatosis.
  • Diagnosis can be confirmed by histopathological analysis.
  • [MeSH-major] Fibroma / pathology. Lipoma / pathology. Orbital Neoplasms / pathology. Orbital Neoplasms / surgery
  • [MeSH-minor] Biopsy, Needle. Blepharoptosis / diagnosis. Blepharoptosis / etiology. Child. Female. Follow-Up Studies. Humans. Immunohistochemistry. Ophthalmologic Surgical Procedures / methods. Rare Diseases. Tomography, X-Ray Computed / methods. Treatment Outcome

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  • (PMID = 21158580.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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95. Xu Y, Jing Y, Ma S, Ma F, Wang Y, Ma W, Li Q: Primary angioleiomyoma in the sellar region: a case report and literature review. Clin Neuropathol; 2010 Jan-Feb;29(1):21-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Angioleiomyoma (vascular leiomyomas, angiomyoma) is a rare, benign soft tissue tumor which consists of a mixture of well-differentiated smooth muscle cells and thick-walled vessels.
  • Gross total resection of the tumor was then performed.
  • The pertinent literature regarding the features of this tumor was reviewed and discussed.
  • CONCLUSIONS: Intracranial angioleiomyoma is a benign soft tissue tumor with excellent prognosis.
  • Early diagnosis of this tumor is difficult.
  • [MeSH-major] Angiomyoma / pathology. Brain / pathology. Brain Neoplasms / pathology
  • [MeSH-minor] Adrenocorticotropic Hormone / metabolism. Early Diagnosis. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neurologic Examination. Prognosis

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  • (PMID = 20040329.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 9002-60-2 / Adrenocorticotropic Hormone
  • [Number-of-references] 14
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96. Adnani A, Chellaoui M, Chat L, Dafiri R: [Unusual appearance of axillary lipoblastoma of infancy]. J Radiol; 2005 Sep;86(9 Pt 1):1043-5
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  • Lipoblastoma is an uncommon benign soft tissue tumor of infancy and early childhood with a predilection for the extremities.
  • CT and MRI can confirm the presence of fat components in the tumor.
  • By showing lipoblastoma proliferation, histology confirms the diagnosis.
  • [MeSH-major] Axilla / pathology. Lipoma / congenital. Soft Tissue Neoplasms / congenital
  • [MeSH-minor] Biopsy. Female. Humans. Infant. Magnetic Resonance Imaging. Neoplasm Recurrence, Local / pathology. Tomography, X-Ray Computed

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  • (PMID = 16224347.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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97. Mnasri H, Bouchoucha S: Granular cell tumour of the perianal region: which therapeutic attitude? Acta Chir Belg; 2005 Feb;105(1):112-3
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  • [Title] Granular cell tumour of the perianal region: which therapeutic attitude?
  • Granular cell tumours are uncommon soft tissue tumours that could be located anywhere throughout the body.
  • Most of time they are benign but the diagnosis of malignancy is difficult to establish on histology: this is why the therapeutic decision is not easy to take in particular for some locations.
  • We report the case of a 18-year old man: he presented, in the perianal region, a granular cell tumour of uncertain malignant potential (so far the first case described in the literature) for which we decided a conservative surgical treatment that failed.
  • [MeSH-major] Anus Neoplasms / surgery. Granular Cell Tumor / surgery

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  • (PMID = 15790218.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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98. Soini Y: Expression of claudins 1, 2, 3, 4, 5 and 7 in various types of tumours. Histopathology; 2005 May;46(5):551-60
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  • There were, however, tumour type-specific differences in their expression.
  • In contrast to epithelial tumours, lymphomas did not express claudins and most soft tissue tumours and naevocytic lesions were negative or showed weaker, mainly cytoplasmic positivity for some claudins.
  • Of non-epithelial tumours, claudin 5 was found only in angiosarcomas and benign vascular tumours, which also showed reactivity for claudins 2, 3 and 7, but was not expressed in any other soft tissue lesions or lymphomas.
  • CONCLUSIONS: The results show that claudins 1, 2, 3, 4, 5 and 7 can be used as markers for epithelial differentiation and to distinguish epithelial neoplasms from lymphomas and selectively also from soft tissue and naevocytic lesions.
  • Since these claudins show type-specific differential expression in epithelial tumours, they may also be of some value in distinguishing different epithelial tumours from each other.
  • Additionally, claudin 5 shows promise as a marker for endothelial lesions compared with other soft tissue lesions.
  • [MeSH-major] Membrane Proteins / biosynthesis. Neoplasms / pathology. Receptors, Cell Surface / biosynthesis

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  • (PMID = 15842637.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CLDN1 protein, human; 0 / CLDN2 protein, human; 0 / CLDN3 protein, human; 0 / CLDN4 protein, human; 0 / CLDN7 protein, human; 0 / Claudin-1; 0 / Claudin-3; 0 / Claudin-4; 0 / Claudins; 0 / Membrane Proteins; 0 / Receptors, Cell Surface
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99. Flucke U, Hulsebos TJ, van Krieken JH, Mentzel T: Myxoid epithelioid sarcoma: a diagnostic challenge. A report on six cases. Histopathology; 2010 Nov;57(5):753-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The neoplasms arose in an extremity (two cases), the abdominal wall, groin, perineum and shoulder (one case each).
  • The tumour stroma, however, revealed prominent myxoid changes, ranging from 50 to 90% (median: 75%).
  • Only one of the proximal type ES showed a SMARCB1 mutation, whereas the other tumours showed no mutation.
  • CONCLUSIONS: The myxoid variant of ES represents a diagnostic challenge and may be confused with other benign and malignant myxoid neoplasms.
  • The main differential diagnosis is myoepithelioma of the skin and soft tissue.

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  • [Copyright] © 2010 Blackwell Publishing Limited.
  • (PMID = 21083605.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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100. Menditti D, Laino L, Mezzogiorno A, Sava S, Bianchi A, Caruso G, Di Maio L, Baldi A: Oral benign fibrous histiocytoma: two case reports. Cases J; 2009;2:9343
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  • [Title] Oral benign fibrous histiocytoma: two case reports.
  • Fibrous histiocytoma is a benign soft tissue tumour arising as a fibrous mass everywhere in the human body.
  • We report two cases of benign fibrous histiocytoma that localized in the oral cavity.

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  • (PMID = 20066060.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2804724
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