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1. Liegl B, Bennett MW, Fletcher CD: Microcystic/reticular schwannoma: a distinct variant with predilection for visceral locations. Am J Surg Pathol; 2008 Jul;32(7):1080-7
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  • Schwannomas are benign, generally nonrecurring tumors most frequently arising in the subcutaneous tissue of adults with no sex predilection.
  • Herein we report 10 cases of a distinctive morphologic variant of schwannoma with predominantly microcystic-reticular morphology and characterize the clinicopathologic spectrum.
  • The tumor size ranged from 0.4 to 23 cm (median size 4.3 cm).
  • Two cases arose in subcutaneous tissue and 1 case each in the upper respiratory tract, the adrenal gland, and deep soft tissue.
  • A surrounding tumor capsule was highlighted with epithelial membrane antigen in 2 out of 10 cases.
  • Microcystic schwannoma represents a distinctive morphologic variant of schwannoma with predilection for visceral locations.
  • [MeSH-major] Gastrointestinal Neoplasms / pathology. Neurilemmoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Child. Female. Humans. Male. Middle Aged. Neurofilament Proteins / analysis. S100 Proteins / analysis

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  • (PMID = 18520439.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neurofilament Proteins; 0 / S100 Proteins
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2. Comunoglu N, Comunoglu C, Ekici AI, Ozkan F, Dervişoglu S: Spindle cell lipoma. Pol J Pathol; 2007;58(1):7-11
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  • Spindle cell lipomas are a group of benign lipogenic soft tissue tumors.
  • Differential diagnosis of this tumor became more important because the number of reports about some other tumors of similar morphology such as mammary type myofibroblastoma and solitary fibrous tumor, are increasing.
  • We think that spindle cell lipomas are desmin negative tumors and this feature helps us to differentiate them especially from mammary type myofibroblastomas of extramammarian soft tissue.
  • [MeSH-major] Lipoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Antigens, CD34 / metabolism. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Liposarcoma / pathology. Male. Middle Aged. Retrospective Studies

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  • (PMID = 17585537.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antigens, CD34
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3. Mehrabi A, Kashfi A, Schemmer P, Sauer P, Encke J, Fonouni H, Friess H, Weitz J, Schmidt J, Büchler MW, Kraus TW: Surgical treatment of primary hepatic epithelioid hemangioendothelioma. Transplantation; 2005 Sep 27;80(1 Suppl):S109-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Epithelioid hemangioendothelioma is a very rare tumor of vascular origin.
  • It can develop in different tissues such as soft tissue, lung, or liver.
  • It can range from benign hemangioma to malignant hemangioendotheliosarcoma.
  • One patient died while she was on the waiting list for LTx due to rapid tumor progression.
  • Until now, no recurrence of local tumor or distant metastases could be observed during follow-up in our series.
  • In our view, LTx represents a potentially important option for patients with a nonresectable tumor.
  • Despite the long waiting time, its often unclear dignity, and a proven progressive growth pattern, living related LTx also plays a potentially important role.
  • Long-term survival of patients with HEH is significantly higher compared to other hepatic malignancies.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / surgery. Liver Neoplasms / surgery

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  • (PMID = 16286886.001).
  • [ISSN] 0041-1337
  • [Journal-full-title] Transplantation
  • [ISO-abbreviation] Transplantation
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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4. Suzuki T, Ueda Y, Shincho M, Mitsui Y, Higuchi Y, Maruyama T, Kondoh N, Nojima M, Yamamoto S, Hirota S, Shima H: [Myolipoma arising from the renal capsule: a case report]. Hinyokika Kiyo; 2008 May;54(5):349-52
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  • Computed tomorraphy and magnetic resonance imaging showed that the tumor was mixed with muscle and fat tissue, faintly enhanced, and located at the lower portion of the left kidney.
  • Although renal angiomyolipoma (AML) was suspected from these findings, we could not rule out a malignant tumor.
  • Histopathological examination revealed the tumor composed of smooth muscle and mature adipose tissue without cytological atypia arising from the renal capsule.
  • The tumor contained no AML-like blood vessels, and was negative for HMB-45 staining.
  • The final diagnosis was myolipoma arising from the renal capsule.
  • Myolipoma is a rare benign neoplasm in the soft tissue of retroperitoneum and abdominal cavity.
  • Since it is difficult to distinguish myolipoma from other benign and malignant tumors with fat tissue only by imaging studies, a surgical approach should be considered.
  • [MeSH-major] Kidney Neoplasms / diagnosis. Lipoma / diagnosis

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  • (PMID = 18546859.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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5. Medina-Franco H, Abarca-Pérez L, Ortiz-López LJ, Hinojosa-Becerril C: [Presentation of gastric cancer as a soft tissue tumor]. Rev Gastroenterol Mex; 2006 Jul-Sep;71(3):308-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Presentation of gastric cancer as a soft tissue tumor].
  • [Transliterated title] Presentación de cáncer gástrico como tumor de tejidos blandos.
  • Soft tissue metastasis of gastric cancer is extremely rare.
  • We report an 82 year old male, who was being evaluated for benign prostate hyperplasia and incidentally a soft tissue mass in the right buttock was discovered.
  • Differential diagnosis included neurofibroma vs. soft tissue sarcoma.
  • Pathology reported the same tumor as the soft tissue mass.
  • We reviewed the literature looking for other cases of soft tissue metastasis of gastric cancer.
  • [MeSH-major] Carcinoma, Signet Ring Cell / secondary. Soft Tissue Neoplasms / secondary. Stomach Neoplasms / pathology

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  • (PMID = 17140053.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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6. Karonidis A, Rigby HS, Orlando A: Collagenosis Nuchae: a case report of a rare and often misdiagnosed condition. J Plast Reconstr Aesthet Surg; 2007;60(3):320-3
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  • [Title] Collagenosis Nuchae: a case report of a rare and often misdiagnosed condition.
  • CN is a rare benign soft tissue tumour that arises from the posterior cervical subcutaneous tissue with predilection for the interscapular and paraspinal regions.
  • The true incidence of CN is probably higher than recognised and CN should be in the differential diagnosis of head and neck lesions.
  • Histological examination is required for the diagnosis.
  • Careful total excision provides cure and accurate diagnosis.
  • [MeSH-major] Fibroma / diagnosis. Head and Neck Neoplasms / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 17293293.001).
  • [ISSN] 1748-6815
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 10
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7. Chiou HJ, Chou YH, Chiu SY, Wang HK, Chen WM, Chen TH, Chang CY: Differentiation of benign and malignant superficial soft-tissue masses using grayscale and color doppler ultrasonography. J Chin Med Assoc; 2009 Jun;72(6):307-15
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  • [Title] Differentiation of benign and malignant superficial soft-tissue masses using grayscale and color doppler ultrasonography.
  • BACKGROUND: This study was performed to evaluate the usefulness of high-resolution grayscale and color Doppler ultrasound to distinguish benign from malignant soft-tissue masses on the basis of ultrasonographic patterns.
  • Each lesion was examined by grayscale and color Doppler ultrasonography to assess its echogenicity, margin, shape, composition, acoustic transmission, size and other patterns.
  • RESULTS: There were a total of 693 benign and 125 malignant masses.
  • Five malignant and 14 benign histologies (including 6 types with inflammation-related, hematoma or pseudoaneurysm) occurred that had more than 10 subjects with each histology.
  • Eight benign histopathologies included cysts, neoplasms, vascular and miscellaneous.
  • There were significant differences (p < 0.05) between the benign and malignant soft-tissue tumors in terms of parameters including tumor margin, shape and size.
  • Benign lesions did not have infiltrated margins or a scalloped shape and malignant tumors tended to be large.
  • However, there was no significant difference (p > 0.05) between the benign and malignant soft-tissue tumors in terms of echogenicity, composition and color Doppler features.
  • CONCLUSION: Ultrasonography with color Doppler imaging is a good modality for characterizing most soft-tissue masses, and tumor size > 5 cm and having infiltrated margin highly suggests malignancy.
  • [MeSH-major] Soft Tissue Neoplasms / ultrasonography. Ultrasonography, Doppler, Color / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Epidermal Cyst / pathology. Epidermal Cyst / ultrasonography. Female. Giant Cell Tumors / pathology. Giant Cell Tumors / ultrasonography. Hemangioma / pathology. Hemangioma / ultrasonography. Humans. Infant. Liposarcoma / pathology. Liposarcoma / ultrasonography. Male. Middle Aged. Neoplasm Metastasis. Neurilemmoma / pathology. Neurilemmoma / ultrasonography. Retrospective Studies

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  • (PMID = 19541566.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China (Republic : 1949- )
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8. Shukla R, Pooja B, Radhika S, Nijhawan R, Rajwanshi A: Fine-needle aspiration cytology of extramammary neoplasms metastatic to the breast. Diagn Cytopathol; 2005 Apr;32(4):193-7
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  • [Title] Fine-needle aspiration cytology of extramammary neoplasms metastatic to the breast.
  • Metastatic breast neoplasms diagnosed over a 6-yr period from 1997 to 2002 were retrieved from the database of the Department of Cytopathology and the clinical, cytopathological, histochemical, and immunohistochemical findings were correlated with the histopathology of the primary tumor.
  • Fifteen cases of metastatic breast neoplasms were encountered constituting 1.47% of all malignant tumors of the breast diagnosed on FNA.
  • The preaspiration clinical diagnosis was either a benign breast lump or a malignancy (primary vs. metastatic).
  • The breast lump was the initial presentation in four cases and the cytodiagnosis of a metastatic malignancy lead to the subsequent detection of the primary malignancy.
  • The adult cases included two cases each of melanoma, small-cell carcinoma, and myeloma; one case of choriocarcinoma; and three cases of soft-tissue sarcomas.
  • The presence of unusual cytomorphological patterns on breast FNA should alert the cytopathologist to the possibility of a metastatic breast neoplasm, even if not suspected clinically.
  • A detailed history of the patient, clinical correlation, and immunocytochemistry helps in establishing an accurate diagnosis, which avoids unnecessary surgery and ensures appropriate treatment.
  • [MeSH-major] Breast / pathology. Breast Neoplasms, Male / pathology. Breast Neoplasms, Male / secondary
  • [MeSH-minor] Adolescent. Adult. Biopsy, Fine-Needle. Child. Female. Humans. Male. Middle Aged. Neoplasm Metastasis / pathology. Predictive Value of Tests

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15754368.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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9. Szollosi Z, Nemeth T, Egervari K, Nemes Z: Histiocyte-like cells expressing factor XIIIa do not belong to the neoplastic cell population in malignant fibrous histiocytoma. Pathol Res Pract; 2005;201(5):369-77
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  • The term malignant fibrous histiocytoma (MFH) is widely used for pleomorphic soft tissue sarcomas without a specific line of differentiation.
  • MFH is included in the category of fibrohistiocytic soft tissue tumors.
  • A morphometric approach compares the measure of nuclear pleomorphism of the factor XIIIa-positive cells with that of the factor XIIIa-negative tumor cells in high-grade MFH.
  • The immunohistochemical approach compares the factor XIIIa-positive and -negative cell populations with regard to mutations of p53 tumor suppressor gene in p53-positive MFH cases.
  • We selected 58 cases of soft tissue pleomorphic or storiform-pleomorphic MFH on the basis of histopathological examinations.
  • We found that mean nuclear area and mean nuclear Ferret diameter in factor XIIIa-positive cells differed significantly from those of the tumor cells in all cases.
  • The immunohistochemical positivity for p53 positivity can be accepted as the manifestation of a missense mutation of TP53 gene and as a marker of neoplastic cells.
  • [MeSH-major] Factor XIIIa / biosynthesis. Histiocytes / chemistry. Histiocytoma, Benign Fibrous / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Cell Nucleus / chemistry. Humans. Immunohistochemistry. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 16047946.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; EC 2.3.2.13 / Factor XIIIa
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10. Plaza JA, Wakely PE Jr, Suster S: Lipoblastic nerve sheath tumors: report of a distinctive variant of neural soft tissue neoplasm with adipocytic differentiation. Am J Surg Pathol; 2006 Mar;30(3):337-44
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  • [Title] Lipoblastic nerve sheath tumors: report of a distinctive variant of neural soft tissue neoplasm with adipocytic differentiation.
  • Benign nerve sheath tumors of soft tissue can occasionally adopt unusual or unfamiliar morphologic appearances that may introduce difficulties for diagnosis, such as multinucleation, bizarre nuclei, intranuclear vacuoles, and other degenerative changes.
  • Tumor cells adopting a signet-ring or lipoblast-like configuration, however, are mostly associated with epithelial malignancies, liposarcoma and melanoma, and have been only rarely observed in spindle cell tumors of soft tissue.
  • We report 5 cases of benign nerve sheath neoplasms that displayed prominent signet-ring cells with lipoblast-like features.
  • The cases presented as solitary soft tissue masses in the groin, thigh, retroperitoneum, and shoulder in 4 men and 1 woman between the ages of 31 to 57 years.
  • The signet-ring cells were negative for mucin stains, cytokeratin, EMA, CEA, and several other differentiation markers.
  • The presence of mature fat and signet-ring lipoblast-like cells within a nerve sheath neoplasm is quite rare and may signify a process of aberrant differentiation.
  • Neurogenic tumors should be added in the differential diagnosis of spindle cell tumors capable of displaying prominent signet-ring cell features.
  • [MeSH-major] Adipose Tissue / pathology. Nerve Sheath Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Carcinoma, Signet Ring Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission. Middle Aged

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  • (PMID = 16538053.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Panzarella MJ, Naqvi AH, Cohen HE, Damron TA: Predictive value of gadolinium enhancement in differentiating ALT/WD liposarcomas from benign fatty tumors. Skeletal Radiol; 2005 May;34(5):272-8
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  • [Title] Predictive value of gadolinium enhancement in differentiating ALT/WD liposarcomas from benign fatty tumors.
  • OBJECTIVE: To determine the predictive value of gadolinium enhancement on MRI in differentiating atypical lipomatous tumor (ALT)/well-differentiated (WD) liposarcoma from benign fatty tumors.
  • Sensitivity, specificity, and positive and negative predictive values for both gadolinium enhancement and biopsy as predictors for the final diagnosis of ALT/WD liposarcoma were calculated.
  • Needle or incisional biopsy yielded 57% sensitivity, 100% specificity, 100% positive predictive value and 63% negative predictive value for a diagnosis of ALT/WD liposarcoma.
  • CONCLUSIONS: Gadolinium enhancement of a homogeneous fatty soft tissue tumor is a sensitive screening tool to determine possible diagnosis of ALT/WD liposarcoma.
  • Biopsy, on the other hand, is specific but insensitive.
  • [MeSH-major] Contrast Media. Gadolinium. Lipoma / diagnosis. Liposarcoma / diagnosis. Magnetic Resonance Imaging
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Sensitivity and Specificity

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  • (PMID = 15742204.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; AU0V1LM3JT / Gadolinium
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12. Sakamoto A, Yoshida T, Matsuura S, Tanaka K, Matsuda S, Oda Y, Hori Y, Yokomizo A, Iwamoto Y: Metastasis to the gluteus maximus muscle from renal cell carcinoma with special emphasis on MRI features. World J Surg Oncol; 2007;5:88
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Metastatic RCC must be differentiated from benign primary soft-tissue tumors because aggressive surgical resection is necessary.
  • CASE PRESENTATION: We present the case of a 65-year-old man with metastatic RCC in the gluteus maximus muscle (3.8 cm in diameter) found on enhanced computed tomography (CT) 6 years after nephrectomy.
  • Because the growth of the lesion was slow, benign tumor was a differential diagnosis.
  • The MRI features were unusual for most soft-tissue tumors having low-signal intensity on T1-WI and high-signal intensity on T2-WI.
  • Therefore, under a diagnosis of metastatic RCC, the lesion was resected together with the surrounding skeletal muscle.
  • CONCLUSION: MRI features of metastatic RCC may be beneficial in differentiating it from primary soft-tissue tumor.

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  • (PMID = 17683570.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1976113
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13. Sailon AM, Cappuccino G, Hameed M, Fleegler EJ: Nodular fasciitis of the hand over the metacarpophalangeal joint: a case report. Eplasty; 2008;8:e38
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: This study describes a case of nodular fasciitis involving the hand and reviews the neoplasm's pertinent clinical, histologic, and pathologic features.
  • RESULTS: We report a case of nodular fasciitis involving the hand of a 55-year-old woman that was treated with marginal excision.
  • CONCLUSIONS: Nodular fasciitis is a self-limited, benign soft tissue tumor composed of fibroblasts and myofibroblasts that typically afflicts younger patients and rarely presents in the hand.
  • Because of its presentation, it can be easily mistaken for a malignant neoplasm.

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  • (PMID = 18725954.001).
  • [ISSN] 1937-5719
  • [Journal-full-title] Eplasty
  • [ISO-abbreviation] Eplasty
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2491338
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14. Czerny C, Nemec S, Krestan C, Gstöttner W: [Benign and malignant lesions in the region of the inner ear and cerebellopontine angle]. Radiologe; 2006 Mar;46(3):197-204
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  • [Title] [Benign and malignant lesions in the region of the inner ear and cerebellopontine angle].
  • [Transliterated title] Benigne und maligne Veränderungen der Innenohr- und Kleinhirnbrückenwinkelregion.
  • Tumorous lesions in the region of the inner ear and cerebellopontine angle are very rare and can be classified into benign and malignant disease forms.
  • The coronary slices can be reconstructed from the axial datasets or in individual cases examined in the coronary plane.HRCT excellently demonstrates osseous lesions and in individual cases - e.g., exostoses - it can simply suffice to perform HRCT of the temporal bone, while HRCT is also excellent for detecting osseous lesions to determine whether the tumor is benign or malignant.MRI, on the other hand, excellently shows the extent of tumor spread because of its superb soft tissue contrast.
  • The two methods should not be considered as competing but rather as complementary and among other aspects exert considerable influence on the therapeutic approach.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Cerebellopontine Angle / diagnostic imaging. Cerebellopontine Angle / pathology. Ear Neoplasms / diagnosis. Ear, Inner / diagnostic imaging. Ear, Inner / pathology

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  • [Cites] Acta Neurochir (Wien). 2002 Oct;144(10):1047-53 [12382133.001]
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  • (PMID = 16418859.001).
  • [ISSN] 0033-832X
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 23
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15. Williams RW, Grave B, Stewart M, Heggie AA: Prenatal and postnatal management of congenital granular cell tumours: a case report. Br J Oral Maxillofac Surg; 2009 Jan;47(1):56-8
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  • Congenital granular cell tumour is a rare, benign, soft tissue lesion of the oral cavity.
  • Large or multiple lesions can cause mechanical obstruction of the oral cavity and may result in prenatal polyhydramnios, and postnatal feeding and respiratory problems.We present a case in which prenatal diagnostic imaging was used in the successful management of an infant with a large congenital granular cell tumour.
  • [MeSH-major] Gingival Neoplasms / diagnosis. Gingival Neoplasms / surgery. Granular Cell Tumor / congenital. Granular Cell Tumor / diagnosis. Ultrasonography, Prenatal

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  • (PMID = 18556098.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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16. Fukunaga M, Suzuki K, Saegusa N, Folpe AL: Composite hemangioendothelioma: report of 5 cases including one with associated Maffucci syndrome. Am J Surg Pathol; 2007 Oct;31(10):1567-72
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  • Composite hemangioendothelioma (HE) is a low-grade malignant vascular tumor showing varying combinations of benign, low-grade malignant, and malignant vascular components.
  • The tumors were composed of a complex admixture of histologic components resembling various vascular lesions.
  • Of 4 cases with follow up (median duration, 8.6 y), 1 tumor recurred locally.
  • We conclude that composite HE should continue to be regarded as a low-grade malignant vascular tumor (HE), with significant potential for local recurrence, but little if any potential for distant metastasis.
  • [MeSH-major] Enchondromatosis / pathology. Hemangioendothelioma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. Female. Humans. Immunoenzyme Techniques. Male. Neoplasm Recurrence, Local

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  • (PMID = 17895759.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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17. Tardío JC: Leiomyomatous nodules in a cellular angiofibroma: a hitherto unreported finding. Virchows Arch; 2009 May;454(5):595-8
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  • Cellular angiofibroma is a benign tumor of the superficial soft tissues of the vulvovaginal and inguinoscrotal regions of adult patients.
  • The case of a 44-year-old female with a perineal cellular angiofibroma containing small leiomyomatous nodules is described in this case report.
  • [MeSH-major] Angiofibroma / pathology. Leiomyoma / pathology. Neoplasms, Multiple Primary / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Female. Fluorescent Antibody Technique, Direct. Humans. Immunohistochemistry. Perineum / pathology

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  • [Cites] Histopathology. 2004 Oct;45(4):360-8 [15469474.001]
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  • (PMID = 19301032.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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18. Sari A, Tunakan M, Bolat B, Cakmakçi H, Ozer E: Lipofibromatosis in a two-year-old girl: a case report. Turk J Pediatr; 2007 Jul-Sep;49(3):319-21
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  • Lipofibromatosis is a recently described rare benign soft tissue tumor of childhood.
  • We report a case of a lipofibromatosis in a two-year-old girl with a painless mass on the plantar aspect of her right foot who developed local recurrence eight months after surgery.
  • The tumor has a high rate of non-destructive recurrence, but there is no metastatic potential.
  • [MeSH-major] Fibroma / pathology. Neoplasm Recurrence, Local / surgery

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  • (PMID = 17990590.001).
  • [ISSN] 0041-4301
  • [Journal-full-title] The Turkish journal of pediatrics
  • [ISO-abbreviation] Turk. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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19. El Samman K, Sedivý P, Syrůcek M, Sebesta P: Unusual groin resistance--a case study. Int Surg; 2010 Apr-Jun;95(2):117-9
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  • Extraskeletal osteochondroma is a benign, cartilaginous, slow-growing tumor with typical location near the joints of hands, feet, and knees.
  • The authors present the case of a 44-year-old patient who experienced increasing pain in the right groin.
  • [MeSH-major] Osteochondroma / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 20718316.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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20. Herawi M, Parwani AV, Edlow D, Smolev JK, Epstein JI: Glomus tumor of renal pelvis: a case report and review of the literature. Hum Pathol; 2005 Mar;36(3):299-302
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  • [Title] Glomus tumor of renal pelvis: a case report and review of the literature.
  • Glomus tumors are uncommon benign perivascular neoplasms that have rarely been described outside of their usual peripheral soft tissue sites.
  • We report a unique case of glomus tumor of the renal pelvis in a 53-year-old woman who presented with microscopic hematuria associated with obstruction of the ureteropelvic junction and marked hydronephrosis.
  • At initial gross examination, the tumor mimicked a urothelial carcinoma.
  • [MeSH-major] Glomus Tumor / diagnosis. Kidney Neoplasms / diagnosis. Kidney Pelvis
  • [MeSH-minor] Diagnosis, Differential. Female. Hematuria. Humans. Hydronephrosis. Immunohistochemistry. Middle Aged. Nephrectomy. Ureter / surgery

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  • (PMID = 15791575.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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21. Dobashi Y, Watanabe H, Matsubara M, Yanagawa T, Raz A, Shimamiya T, Ooi A: Autocrine motility factor/glucose-6-phosphate isomerase is a possible predictor of metastasis in bone and soft tissue tumours. J Pathol; 2006 Jan;208(1):44-53
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  • [Title] Autocrine motility factor/glucose-6-phosphate isomerase is a possible predictor of metastasis in bone and soft tissue tumours.
  • In order to assess the involvement of autocrine motility factor (AMF) in mesenchymal tumours, AMF protein and mRNA expression was analysed in tumours, tumour-like lesions, and other lesions of bone and soft tissue.
  • Chordoid, chondroid, and muscular tumours revealed higher immunoreactivity in both benign and malignant tumours.
  • Generally, malignant tumours revealed higher expression of AMF than benign tumours of the same histopathological lineage, except for dermatofibroma/dermatofibrosarcoma protuberans.
  • Collectively, AMF was observed in a wide spectrum of lesions of mesenchymal tissue, supporting the notion that it is involved in various cellular functions, including proliferation, differentiation, metabolism, and metastasis.
  • [MeSH-major] Bone Neoplasms / metabolism. Glucose-6-Phosphate / metabolism. Glucose-6-Phosphate Isomerase / analysis. Soft Tissue Neoplasms / metabolism
  • [MeSH-minor] Cell Line, Tumor. Humans. Immunoblotting / methods. Immunohistochemistry / methods. Neoplasm Metastasis. Neoplasm Proteins / analysis. Proteasome Inhibitors. RNA, Messenger / analysis. RNA, Neoplasm / analysis. Reverse Transcriptase Polymerase Chain Reaction / methods

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  • [Copyright] Copyright 2005 Pathological Society of Great Britain and Ireland.
  • (PMID = 16294294.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-51714
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Proteasome Inhibitors; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 56-73-5 / Glucose-6-Phosphate; EC 5.3.1.9 / Glucose-6-Phosphate Isomerase
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22. Cerdá-Nicolás M, Löpez-Gines C, Gil-Benso R, Benito R, Pellin A, Ruiz-Saurí A, Sanchos-Garcia J, Roldan P, Talamantes F, Barberá J: Solitary fibrous tumor of the orbit: morphological, cytogenetic and molecular features. Neuropathology; 2006 Dec;26(6):557-63
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  • [Title] Solitary fibrous tumor of the orbit: morphological, cytogenetic and molecular features.
  • Solitary fibrous tumor (SFT), a benign neoplasm arising in mesenchymal structures, was initially described in the pleura but subsequently has also been documented in other locations.
  • It is uncommon in the orbit, where it closely resembles other benign spindle-shaped mesenchymal tumors of this area such as schwannoma, meningioma or hemangiopericytoma.
  • Measurement of DNA content revealed a DNA index of 1, indicating a diploid peak in 95% of the tumor cells.
  • No p14(ARF), p15(INK4B) and p16(INK4A) deletions or hypermethylation were observed in this benign tumor.
  • Following surgical resection and radiotherapy, the patient showed no tumor relapse after one year of follow-up.
  • [MeSH-major] Fibroma / genetics. Fibroma / pathology. Orbital Neoplasms / genetics. Orbital Neoplasms / pathology
  • [MeSH-minor] Adult. Cyclin-Dependent Kinase Inhibitor p15 / genetics. Cyclin-Dependent Kinase Inhibitor p16 / genetics. DNA Methylation. Exons / genetics. Female. Gene Deletion. Genes, p53 / genetics. Humans. Magnetic Resonance Imaging. Point Mutation. Proto-Oncogene Proteins c-mdm2 / genetics. Soft Tissue Neoplasms / genetics. Soft Tissue Neoplasms / pathology. Tumor Suppressor Protein p14ARF / genetics

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  • (PMID = 17203593.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p15; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Tumor Suppressor Protein p14ARF; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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23. Hamada K, Tomita Y, Ueda T, Enomoto K, Kakunaga S, Myoui A, Higuchi I, Yoshikawa H, Hatazawa J: Evaluation of delayed 18F-FDG PET in differential diagnosis for malignant soft-tissue tumors. Ann Nucl Med; 2006 Dec;20(10):671-5
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  • [Title] Evaluation of delayed 18F-FDG PET in differential diagnosis for malignant soft-tissue tumors.
  • OBJECTIVE: Positron emission tomography (PET) with 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) has been used for the evaluation of soft-tissue tumors.
  • However, the range of accumulation of 18F-FDG for malignant soft-tissue lesions overlaps with that of benign lesions.
  • The aim of this study is to investigate the usefulness of delayed 18F-FDG PET imaging in the differentiation between malignant and benign soft-tissue tumors.
  • METHODS: Fifty-six patients with soft-tissue tumors underwent whole body 18F-FDG PET scan at 1 hour (early scan) and additional scan at 2 hours after injection (delayed scan).
  • The standardized uptake value (SUV(max)) of the tumor was determined, and the retention index (RI) was defined as the ratio of the increase in SUV(max) between early and delayed scans to the SUV(max) in the early scan.
  • Surgical resection with histopathologic analysis confirmed the diagnosis.
  • RESULTS: Histological examination proved 19 of 56 patients to have malignant soft-tissue tumors and the rest benign ones.
  • In the scans of all 56 patients, there was a statistically significant difference in the SUV(max) between malignant and benign lesions in the early scan (5.50 +/- 5.32 and 3.10 +/- 2.64, respectively, p < 0.05) and in the delayed scan (5.95 +/- 6.40 and 3.23 +/- 3.20, respectively, p < 0.05).
  • The mean RI was not significantly different between malignant and benign soft-tissue tumors (0.94 +/- 23.04 and -2.03 +/- 25.33, respectively).
  • CONCLUSIONS: In the current patient population, no significant difference in the RI was found between malignant and benign soft-tissue lesions.
  • Although the mean SUV(max) in the delayed scan for malignant soft-tissue tumors was significantly higher than that for benign ones, there was a marked overlap.
  • The delayed 18F-FDG PET scan may have limited capability to differentiate malignant soft-tissue tumors from benign ones.
  • [MeSH-major] Fluorodeoxyglucose F18 / administration & dosage. Image Enhancement / methods. Positron-Emission Tomography / methods. Soft Tissue Neoplasms / radionuclide imaging
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Radiopharmaceuticals / administration & dosage. Reproducibility of Results. Sensitivity and Specificity. Time Factors

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  • (PMID = 17385305.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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24. Ozcan C, Apaydin FD, Görür K, Apa DD: Peripheral giant cell granuloma of the mandibular condyle presenting as a preauricular mass. Eur Arch Otorhinolaryngol; 2005 Mar;262(3):178-81
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  • Some rare extraparotid lesions, originating from the temporomandibular joint and the mandible itself, also share the same localization and therefore are to be taken into consideration for the differential diagnosis with parotid lesions.
  • Peripheral GCG (PGCG) is an exophytic soft tissue lesion originating from the periodontal ligament and periosteum.
  • Central GCG (CGCG) is an uncommon benign fibro-osseous lesion generally presenting as an expansible mass with cortical bone defect.
  • The brown tumor of hyperparathyroidism and giant cell tumor must be ruled out because of the microscopic similarities of these lesions.
  • The first case of PGCG of the mandible condyle is presented, and attention is drawn to mandibular diseases for the differential diagnosis of the preauricular mass.
  • [MeSH-major] Ear / pathology. Granuloma, Giant Cell / pathology. Mandibular Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy, Needle. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Tomography, X-Ray Computed

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  • (PMID = 15133683.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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25. Jung SM, Chang PY, Luo CC, Huang CS, Lai JY, Hsueh C: Lipoblastoma/lipoblastomatosis: a clinicopathologic study of 16 cases in Taiwan. Pediatr Surg Int; 2005 Oct;21(10):809-12
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  • Lipoblastoma/lipoblastomatosis is an uncommon benign lipomatous tumor affecting mainly infants and children.
  • [MeSH-major] Lipoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16180007.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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26. Dawamneh MF, Amra NK, Amr SS: Low grade fibromyxoid sarcoma: report of a case with fine needle aspiration cytology and histologic correlation. Acta Cytol; 2006 Mar-Apr;50(2):208-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Low grade fibromyxoid sarcoma: report of a case with fine needle aspiration cytology and histologic correlation.
  • BACKGROUND: Low grade fibromyxoid sarcoma has been fully described histologically; however, the fine needle aspiration (FNA) cytologic findings are scantily defined, and the distinction from other benign and malignant soft tissue tumors can be difficult.
  • The excised tumor was well circumscribed, focally infiltrating the surrounding muscles.
  • The tumor cells were spindly, with fusiform, uniform nuclei.
  • The tumor cells were positive for vimentin, alpha-1-antitrypsin and lysozyme and negative for S-100, actin, desmin and CD34.
  • CONCLUSION: Although low grade fibromyxoid sarcoma is a rare neoplasm, it should be recognized and distinguished from other soft tissue tumors because of its low malignant potential.
  • The definitive FNA cytologic diagnosis can be challenging but is possible if the tumor is adequately sampled, with multiple passes from different areas.
  • All spindle cell tumors with myxoid changes, such as myxoid liposarcoma, myxofibrosarcoma, cellular myxoma, myxoid leiomyosarcoma and peripheral nerve sheath tumors, should be considered in the differential diagnosis.
  • [MeSH-major] Fibrosarcoma / diagnosis. Fibrosarcoma / pathology. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / pathology. Thoracic Neoplasms / diagnosis. Thoracic Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy, Fine-Needle / methods. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Sensitivity and Specificity. Treatment Outcome

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  • (PMID = 16610692.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Ilgenfritz RM, Jones KB, Lueck N, Buckwalter JA: Intraosseous neurilemmoma involving the distal tibia and fibula: a case report. Iowa Orthop J; 2006;26:138-43
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  • Schwannoma, or neurilemmoma, is a benign nerve sheath tumor most commonly located in the soft tissue.
  • We present the case of a neurilemmoma affecting both the distal fibula and tibia.
  • Although rare, intraosseous neurilemmoma should be included on the differential diagnosis of painful, radiographically benign-appearing lesions arising in long bones.
  • [MeSH-major] Bone Neoplasms / diagnosis. Fibula. Neurilemmoma / diagnosis. Tibia

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  • (PMID = 16789465.001).
  • [ISSN] 1541-5457
  • [Journal-full-title] The Iowa orthopaedic journal
  • [ISO-abbreviation] Iowa Orthop J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1888578
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28. Trisvetova EL: [Clinical diagnostics of papillary fibroelastoma]. Klin Med (Mosk); 2007;85(12):7-11
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  • Papillary fibroelastoma (PFE) is a benign heart tumor, the diagnosis of which is difficult.
  • Clinical manifestations of PFE are non-specific and scarce, and for this reason the tumor is often revealed during a heart surgery of an autopsy.
  • PFE affects patients of all ages from neonates to 96-year-old ones and is often localized on valvular cusps, although vegetations may appear on other intracardiac structures.
  • The histogenesis of the tumor is unclear; there are several theories of PFE origin (hemodynamic effects on the myocardium, viral theory, iatrogenic theory etc.
  • ) Macroscopically the tumor is small size, villous, whitish-grey, consists of a pedicle and villi of gely-like soft or dense-elastic consistence.
  • The mobility of the tumor and the fragmentation of its tissue lead to its main complications such as obstruction of cardiac cameras (in-flow and out-flow disorders) and embolic syndrome in various basins (the brain, coronary arteries, the eye, the kidneys, and the lungs).
  • The diagnosis of PFE is made using EchoCG, preferably transesophageal one.
  • Treatment of PFE is surgical and consists of tumor or cusp removal.
  • PFE should be differentiated from other benign and malignant heart tumors, infective endocarditis, heart echinococcosis, coronary artery disease, and cerebrovascular diseases.
  • [MeSH-major] Cardiac Surgical Procedures / methods. Fibroma. Heart Neoplasms. Ventricular Function / physiology
  • [MeSH-minor] Diagnosis, Differential. Echocardiography, Transesophageal. Humans. Papillary Muscles / pathology. Papillary Muscles / ultrasonography. Prognosis

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  • (PMID = 18318158.001).
  • [ISSN] 0023-2149
  • [Journal-full-title] Klinicheskaia meditsina
  • [ISO-abbreviation] Klin Med (Mosk)
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Russia (Federation)
  • [Number-of-references] 49
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29. Hakverdi S, Kalaci A, Yaldiz M, Akansu B: Glomus tumor of the hip. An unusual location. Saudi Med J; 2009 Feb;30(2):299-301
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  • [Title] Glomus tumor of the hip. An unusual location.
  • Glomus tumors are usually benign neoplasms that occur in the dermis or subcutaneous tissues of the extremities.
  • On physical examination, there was a soft palpable subcutaneous mass and severe tenderness in the left hip.
  • The histopathologic diagnosis was a glomus tumor.
  • [MeSH-major] Glomus Tumor / pathology. Hip. Soft Tissue Neoplasms / pathology

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  • (PMID = 19198725.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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30. Jeon DG, Lee SY, Kim JW: Bone primary sarcomas undergone unplanned intralesional procedures - the possibility of limb salvage and their oncologic results. J Surg Oncol; 2006 Dec 1;94(7):592-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: It is quite rare but some primary sarcomas of the bone can be misdiagnosed as benign and be treated using intralesional procedures.
  • An unplanned surgical excision occurs when tumors are removed without the appropriate preoperative evaluation and consideration for the need to obtain tumor-free margins.
  • Residual tumor tissue as a result of unplanned excision of soft tissue sarcoma is a risk factor for local recurrence.
  • Limb salvage procedures are worthwhile in cases whose initial radiographic findings simulate benign lesions, showing favorable response to neoadjuvant chemotherapy.
  • The relative contraindication to the limb salvage is cases with a history of a pathologic fracture and extensive operative fixation.
  • [MeSH-major] Bone Neoplasms / surgery. Limb Salvage. Osteosarcoma / surgery. Sarcoma / surgery
  • [MeSH-minor] Adolescent. Adult. Chemotherapy, Adjuvant. Curettage. Female. Humans. Lower Extremity / surgery. Male. Middle Aged. Neoplasm Recurrence, Local. Soft Tissue Neoplasms / mortality. Soft Tissue Neoplasms / surgery. Survival Rate. Treatment Outcome


31. Vered M, Allon I, Buchner A, Dayan D: Clinico-pathologic correlations of myofibroblastic tumors of the oral cavity. II. Myofibroma and myofibromatosis of the oral soft tissues. J Oral Pathol Med; 2007 May;36(5):304-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinico-pathologic correlations of myofibroblastic tumors of the oral cavity. II. Myofibroma and myofibromatosis of the oral soft tissues.
  • BACKGROUND: Myofibroma is a solitary benign tumor of myofibroblasts.
  • The clinico-pathologic correlations of myofibroma/myofibromatosis confined only to oral soft tissues were analyzed.
  • METHODS: In the English language literature, 41 myofibroma and 12 myofibromatosis cases involving the oral soft tissues were found.
  • RESULTS: Age at time of diagnosis of oral mucosa myofibroma ranged from birth to 70 years (mean 21.7 years), considerably higher than myofibroma in other parts of the body.
  • Male:female ratio was 1:1.6, contrary to the male predominance in other parts of the body.
  • Myofibromatosis involving oral soft tissues was diagnosed at birth in nine (75%) patients, within the first year in two, and as a young adult in one.
  • CONCLUSIONS: Myofibroma should be included in the clinical differential diagnosis of masses of the oral soft tissues, especially in the tongue and buccal mucosa of children and adolescents.
  • Histological differential diagnosis includes benign and malignant spindle-shaped lesions.
  • [MeSH-major] Lip Neoplasms / pathology. Mouth Mucosa / pathology. Myofibromatosis / pathology. Neoplasms, Muscle Tissue / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Humans. Infant. Male

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  • [CommentIn] J Oral Pathol Med. 2008 Jan;37(1):62 [18154581.001]
  • (PMID = 17448141.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Denmark
  • [Number-of-references] 54
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32. Mankin HJ, Hornicek FJ: Diagnosis, classification, and management of soft tissue sarcomas. Cancer Control; 2005 Jan-Feb;12(1):5-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis, classification, and management of soft tissue sarcomas.
  • BACKGROUND: Soft tissue sarcomas are challenging to oncologists due to their unique character, the infrequency of their occurrence, and the difficulties in predicting outcomes.
  • METHODS: The various types of soft tissue tumors are defined, and the statistics for the Orthopaedic Oncology Group in relation to them are reviewed and compared with literature references.
  • Outcome was affected by patient age, tumor anatomic site, tumor stage, and a history of recurrence.
  • [MeSH-major] Sarcoma / diagnosis. Sarcoma / therapy
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Fibrosarcoma / diagnosis. Fibrosarcoma / therapy. Histiocytoma, Benign Fibrous / diagnosis. Histiocytoma, Benign Fibrous / therapy. Humans. Leiomyosarcoma / diagnosis. Leiomyosarcoma / therapy. Liposarcoma / diagnosis. Liposarcoma / therapy. Male. Middle Aged. Neoplasm Staging / methods. Neurofibrosarcoma / diagnosis. Neurofibrosarcoma / therapy. Outcome Assessment (Health Care). Rhabdomyosarcoma / diagnosis. Rhabdomyosarcoma / therapy. Sarcoma, Clear Cell / diagnosis. Sarcoma, Clear Cell / therapy. Sarcoma, Synovial / diagnosis. Sarcoma, Synovial / therapy. Survival Analysis

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  • (PMID = 15668648.001).
  • [ISSN] 1073-2748
  • [Journal-full-title] Cancer control : journal of the Moffitt Cancer Center
  • [ISO-abbreviation] Cancer Control
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 205
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33. Mavrogenis AF, Galanakos S, Savvidou OD, Papagelopoulos PJ: Adamantinoma of the tibia mimicking a benign cystic lesion: a case report. Clin Podiatr Med Surg; 2010 Jan;27(1):157-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adamantinoma of the tibia mimicking a benign cystic lesion: a case report.
  • Adamantinoma of the long bones is a rare primary malignant bone tumor accounting for less than 1% of all primary malignant bone tumors.
  • Advanced or recurrent lesions may be associated with destruction of the cortex and soft tissue extension.
  • In this article, the authors present a case report of a patient with a distal tibia adamantinoma mimicking a benign cystic lesion.
  • [MeSH-major] Adamantinoma / diagnosis. Bone Cysts / diagnosis. Bone Neoplasms / diagnosis. Tibia
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male

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  • (PMID = 19963177.001).
  • [ISSN] 1558-2302
  • [Journal-full-title] Clinics in podiatric medicine and surgery
  • [ISO-abbreviation] Clin Podiatr Med Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Policarpio-Nicolas ML, Abbott TE, Dalkin AC, Bennett-Wick J, Frierson HF Jr: Phosphaturic mesenchymal tumor diagnosed by fine-needle aspiration and core biopsy: a case report and review of literature. Diagn Cytopathol; 2008 Feb;36(2):115-9
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  • [Title] Phosphaturic mesenchymal tumor diagnosed by fine-needle aspiration and core biopsy: a case report and review of literature.
  • Oncogenic (tumor-induced) osteomalacia is a rare paraneoplastic syndrome of phosphate wasting that is frequently associated with phosphaturic mesenchymal tumor (PMT).
  • As the cytologic features of this tumor apparently have not been reported, we describe the fine-needle aspiration (FNA) findings for PMT that arose from the gluteal soft tissue in a patient with hypophosphatemia and multiple fractures secondary to osteomalacia.
  • The differential diagnosis included a variety of benign and malignant spindle cell neoplasms such as monophasic synovial sarcoma, leiomyoma, peripheral nerve sheath tumor, fibrosarcoma, and, less likely, metastatic melanoma and sarcomatoid carcinoma.
  • The bland-appearing cytologic features of a spindle cell tumor in a patient with osteomalacia should suggest the diagnosis of PMT.
  • [MeSH-major] Bone Neoplasms / diagnosis. Neoplasms, Connective and Soft Tissue / diagnosis. Phosphates / urine

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18181193.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Phosphates
  • [Number-of-references] 21
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35. Anders JO, Aurich M, Lang T, Wagner A: Solitary fibrous tumor in the thigh: review of the literature. J Cancer Res Clin Oncol; 2006 Feb;132(2):69-75
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  • [Title] Solitary fibrous tumor in the thigh: review of the literature.
  • Despite SFTs are generally benign, well-circumscribed soft tissue tumors new cases should be presented and followed up carefully to monitor their biological behavior.
  • In general for tumor classification a biopsy is state of the art.
  • MRI and ultrasound are not sufficient for differential diagnosis.
  • Once property identified and defined by size and location, resection with intact tumor capsule may result in full recovery of the patient.
  • The tumor was classified as a benign SFT.
  • The diagnosis based on histological findings and the presence of the positive immunohistochemical markers Vimentin, CD34, and CD99.
  • The complete tumor resection with intact capsule was achieved in a final operation.
  • [MeSH-major] Biomarkers, Tumor / analysis. Fibroma / diagnosis. Fibroma / surgery. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / surgery. Thigh
  • [MeSH-minor] Adult. Antigens, CD / analysis. Antigens, CD34 / analysis. Antigens, CD99. Cell Adhesion Molecules / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Vimentin / analysis

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  • (PMID = 16283380.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / Antigens, CD99; 0 / Biomarkers, Tumor; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Vimentin
  • [Number-of-references] 45
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36. Ganly I, Patel SG, Stambuk HE, Coleman M, Ghossein R, Carlson D, Edgar M, Shah JP: Solitary fibrous tumors of the head and neck: a clinicopathologic and radiologic review. Arch Otolaryngol Head Neck Surg; 2006 May;132(5):517-25
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  • PATIENTS: Twelve patients with solitary fibrous tumors of the head and neck identified from the pathology and soft tissue tumor databases at Memorial Sloan-Kettering Cancer Center, New York, NY, from 1990 to 2004.
  • All cases were reviewed by 3 experienced pathologists, 1 of whom is an experienced soft tissue tumor pathologist.
  • The diagnosis was confirmed by microscopic features on hematoxylin-eosin staining and by positive staining for CD34 and Bcl2 on immunohistochemical analysis.
  • Tumors were scored for mitotic activity, cellularity, nuclear pleomorphism, necrosis, and the presence of a malignant component.
  • Details on patient characteristics, tumor characteristics, previous treatment and surgery, adjuvant treatment, and outcome were recorded from clinical records.
  • Pathologic findings showed that 9 tumors were benign and 3 were malignant.
  • CONCLUSIONS: Solitary fibrous tumors of the head and neck region are rare and most commonly benign.
  • The diagnosis depends on microscopic and immunohistochemical features, although imaging may help.
  • [MeSH-major] Neoplasms, Fibrous Tissue / pathology. Otorhinolaryngologic Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Antigens, CD / analysis. Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Cell Adhesion Molecules / analysis. Diagnosis, Differential. Disease Progression. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Mitosis / physiology. Proto-Oncogene Proteins c-bcl-2 / analysis. Subcutaneous Tissue / pathology. Survival Rate. Tomography, X-Ray Computed

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  • (PMID = 16702568.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Proto-Oncogene Proteins c-bcl-2
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37. Domanski HA, Akerman M, Engellau J, Gustafson P, Mertens F, Rydholm A: Fine-needle aspiration of neurilemoma (schwannoma). A clinicocytopathologic study of 116 patients. Diagn Cytopathol; 2006 Jun;34(6):403-12
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  • In addition, the utility of adjunctive techniques was analyzed and other spindle-cell lesions in the differential diagnoses were discussed.
  • An unequivocal, benign diagnosis was rendered by FNAC in 80 cases, 67 of which were correctly labelled as neurilemoma in a review of the original cytology reports.
  • There were 6 false-positive malignant diagnoses while 23 smears were considered insufficient and 7 inconclusive as to whether benign or malignant.
  • On reevaluation, the diagnostic smears in most cases contained spindle cells with wavy nuclei embedded in a fibrillar, occasionally collagenous, and/or myxoid matrix and Antoni A/Antoni B tissue fragments.
  • Thus most neurilemomas have distinct cytomorphologic features that allow correct diagnosis.
  • Furthermore aspirates showing predominantly Antoni A features, nuclear pleomorphism, and/or myxoid changes can easily be confused with other types of benign or malignant soft-tissue tumors.
  • [MeSH-major] Biopsy, Fine-Needle. Neurilemmoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Diagnosis, Differential. False Positive Reactions. Female. Humans. Male. Middle Aged. S100 Proteins / metabolism. Sarcoma / pathology. Sensitivity and Specificity

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  • (PMID = 16680779.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins
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38. Vaz G, Richard A, Guyen O, Bejui-Hugues J, Carret JP: [Desmoplastic fibroma or bone desmoid tumor: two cases]. Rev Chir Orthop Reparatrice Appar Mot; 2005 Dec;91(8):782-7
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  • [Title] [Desmoplastic fibroma or bone desmoid tumor: two cases].
  • [Transliterated title] Le fibrome desmoplastique ou fibrome desmoïde osseux: à propos de 2 nouveaux cas d'une tumeur osseuse rare.
  • Desmoplastic fibroma or desmoid bone tumor is a rare tumor described for the first time by Jaffe in 1958.
  • It accounts for 0.1 to 0.3% of all benign bone tumors.
  • Histology is required for certain diagnosis of desmoplastic fibroma.
  • The tumor is composed of sparse fibroblasts in a rich background of collagen fibers, a histological presentation exactly the same as soft tissue desmoid fibroma.
  • The observations illustrate the radiological diagnosis.
  • MRI was used to search for local extension in bone or soft tissues.
  • Biopsy is necessary to confirm the diagnosis.
  • Surgery is the optimal treatment, with tumor resection as wide as possible depending on the localization.
  • [MeSH-major] Bone Neoplasms. Fibroma, Desmoplastic. Fibromatosis, Aggressive. Pelvic Bones. Tibia

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  • (PMID = 16553001.001).
  • [ISSN] 0035-1040
  • [Journal-full-title] Revue de chirurgie orthopédique et réparatrice de l'appareil moteur
  • [ISO-abbreviation] Rev Chir Orthop Reparatrice Appar Mot
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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39. Baba T, Kariya M, Higuchi T, Mandai M, Matsumura N, Kondoh E, Miyanishi M, Fukuhara K, Takakura K, Fujii S: Neuropilin-1 promotes unlimited growth of ovarian cancer by evading contact inhibition. Gynecol Oncol; 2007 Jun;105(3):703-11
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  • While there are some reports of NRP-1 expression in ovarian neoplasm, those results differ in pattern of its expression and its role in ovarian cancer is still unclear.
  • METHODS: NRP-1 expression was analyzed with eighty-seven ovarian tissue samples by immunohistochemistry and four ovarian cell lines by quantitative RT-PCR and Western blotting.
  • To detect its molecular role in ovarian cancer, WST-1 assay, invasion assay and soft agar assay were performed with or without NRP-1 suppression by the introduction of short hairpin RNAs.
  • RESULTS: NRP-1 expression was found to be enhanced in ovarian cancer compared with ovarian surface epithelium (OSE), benign adenoma and tumors of low malignant potential.
  • Suppression of NRP-1 also decreased cell growth in soft agar and invasion to the extracellular matrix in vitro.
  • [MeSH-major] Cell Communication / physiology. Contact Inhibition / physiology. Neuropilin-1 / physiology. Ovarian Neoplasms / metabolism
  • [MeSH-minor] Cell Adhesion / physiology. Cell Count. Cell Growth Processes / physiology. Cell Line, Tumor. Female. Humans. Immunohistochemistry. Middle Aged. Neoplasm Invasiveness. RNA, Small Interfering / genetics

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  • (PMID = 17376520.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Small Interfering; 144713-63-3 / Neuropilin-1
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40. Koplin SA, Twohig MH, Lund DP, Hafez GR: Omental lipoblastoma. Pathol Res Pract; 2008;204(4):277-81
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  • This unusual tumor is only the eighth reported omental lipoblastoma [J. Hicks, A. Dilley, D. Patel, J.
  • 11 (2001) 342-349; S. Weiss and J.
  • Goldblum, Enzinger and Weiss's Soft Tissue Tumors, fourth ed., Mosby, St. Louis, MO, 2001, pp.
  • Lakhoo, Omental lipoblastoma in a child; diagnosis based in CT density measurements. J. Pediatr. Hematol. Oncol.
  • Pereira, E.R. de Oliveira, M.
  • Alvarenga, Sonographic features of benign intraperitoneal lipomatous tumors in children-report of 4 cases. Pediatr. Radiol.
  • Bullerdiek, Intragenic breakpoint within RAD51L1 in a t(6;14)(p21.3;q24) of a pulmonary chondroid hamartoma. Cytogenet.
  • [MeSH-major] Neoplasms, Adipose Tissue / pathology. Omentum / pathology. Peritoneal Neoplasms / pathology
  • [MeSH-minor] Chromosomes, Human, Pair 14. Chromosomes, Human, Pair 8. Diagnosis, Differential. Gene Expression Regulation, Neoplastic. Humans. Infant. Karyotyping. Liposarcoma, Myxoid / pathology. Male. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18276084.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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41. Bettex S, Guillou L, Jovanovic B, Favarger N: [Fibro-osseous pseudotumor of the thumb. Report of a case]. Chir Main; 2009 Apr;28(2):107-12
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  • [Title] [Fibro-osseous pseudotumor of the thumb. Report of a case].
  • Fibro-osseous tumor of the digits is an uncommon, benign condition with an excellent prognosis after local excision.
  • Like myositis ossificans, clinical and histological features may mimic a malignant tumour, especially an extraskeletal osteosarcoma.
  • We report the case of a 15-year-old boy who presented with a slow-growing mass of the left thumb, which turned out to be a fibro-osseous tumor on microscopic examination.
  • [MeSH-major] Fibrous Dysplasia of Bone / diagnosis. Fibrous Dysplasia of Bone / surgery. Thumb
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Fibroma, Ossifying / diagnosis. Fibroma, Ossifying / surgery. Humans. Male. Osteosarcoma / diagnosis. Osteosarcoma / surgery. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / surgery. Treatment Outcome

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  • (PMID = 19233702.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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42. Sirvent N, Coindre JM, Maire G, Hostein I, Keslair F, Guillou L, Ranchere-Vince D, Terrier P, Pedeutour F: Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR. Am J Surg Pathol; 2007 Oct;31(10):1476-89
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  • [Title] Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR.
  • Atypical lipomatous tumor/well-differentiated liposarcomas and dedifferentiated liposarcomas are characterized by the amplification of MDM2 and CDK4 genes.
  • To evaluate the accuracy of fluorescence in situ hybridization (FISH) analysis in the differential diagnosis of adipose tissue tumors, we investigated MDM2-CDK4 status by FISH, real-time polymerase chain reaction (PCR) [quantitative PCR (Q-PCR)] and immunohistochemistry (IHC) in a series of 200 adipose tumors.
  • First, we evaluated MDM2-CDK4 amplification and expression in a series of 94 well-defined adipose tissue tumors.
  • We then used the same techniques as complementary diagnostic tools in a series of 106 adipose and soft tissue tumors of unclear diagnosis to distinguish between (i) lipomas and atypical lipomatous tumor/well-differentiated liposarcomas, (ii) malignant undifferentiated tumors and dedifferentiated liposarcomas, and (iii) a variety of benign tumors and liposarcomas.
  • When tumor cells represented a minor component of the tumor tissue, such as with inflammatory tumors, FISH was more powerful than Q-PCR by allowing visualization of individual cells.
  • In conclusion, we recommend that the evaluation of MDM2-CDK4 amplification using FISH or Q-PCR be used to supplement IHC analysis when diagnosis of adipose tissue tumors is not possible based on clinical and histologic information alone.
  • [MeSH-major] Cyclin-Dependent Kinase 4 / genetics. Immunohistochemistry / methods. In Situ Hybridization, Fluorescence / methods. Lipoma / genetics. Liposarcoma / diagnosis. Nucleic Acid Amplification Techniques. Proto-Oncogene Proteins c-mdm2 / genetics. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adipocytes / metabolism. Adipocytes / pathology. Adipose Tissue / metabolism. Adipose Tissue / pathology. Adolescent. Adult. Aged. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Female. Gene Expression Profiling / methods. Humans. Male. Middle Aged. Paraffin Embedding. Reproducibility of Results. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17895748.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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43. Zhou P, Zhang H, Bu H, Yin X, Zhang R, Fu J, Zhang Z, Chen H, Wei B, Liu X: Paravertebral glomangiomatosis. Case report. J Neurosurg; 2009 Aug;111(2):272-7
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  • Glomangiomatosis is benign but may manifest as diffusely, locally infiltrating lesions and recur after simple excision.
  • The clinicopathological features, in conjunction with the immunostaining pattern and ultrastructural features, confirmed the diagnosis.
  • Glomangiomatosis is an extremely rare soft-tissue lesion.
  • [MeSH-major] Glomus Tumor / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • [ErratumIn] J Neurosurg. 2009 Dec;111(6):1291
  • (PMID = 19267531.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 17
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44. Agostini T, Catelani C, Acocella A, Franchi A, Bertolai R, Sacco R, Lazzeri D, Shokrollahi K: Spindle cell liposarcoma of the face: case report and literature review. Br J Dermatol; 2010 Sep;163(3):638-40
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  • Liposarcoma is a common soft tissue sarcoma accounting for approximately 20% of all mesenchymal tumours across all ages.
  • Recently, collaborative research in the specialties of pathology and genetics has led to the delineation of several tumour variants with different behaviours and prognoses, one of which includes the very rare spindle cell liposarcoma (SCL) subtype.
  • We present the first case of an SCL arising in the subcutaneous tissue of the forehead of a 78-year-old man.
  • In light of the rarity of this tumour, we describe the tumour and its clinical and pathological characteristics and undertake a literature review to clarify the surgical management and prognosis of SCL, and increase awareness to avoid misdiagnosis of a benign soft tissue neoplasm.
  • [MeSH-major] Facial Neoplasms / pathology. Liposarcoma / pathology

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  • [Copyright] © 2010 The Authors. Journal Compilation © 2010 British Association of Dermatologists.
  • (PMID = 20456346.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
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45. Shelekhova KV: [Morphologic features of reticular (retiform) perineuroma]. Vopr Onkol; 2009;55(1):79-82
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  • [Title] [Morphologic features of reticular (retiform) perineuroma].
  • The report deals with 8 cases of reticular (retiform) perineuroma, a rare soft-tissue variant of the latter.
  • It presents as a lace-like pattern of long cytoplasmic outgrowths of tumor cell clusters in myxoid or tender collagenized stroma.
  • Despite its potential for infiltrative growth, perineuroma has a benign clinical course.
  • [MeSH-major] Neuroma / pathology. Peripheral Nervous System Neoplasms / pathology. Reticulin. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Upper Extremity

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  • (PMID = 19435205.001).
  • [ISSN] 0507-3758
  • [Journal-full-title] Voprosy onkologii
  • [ISO-abbreviation] Vopr Onkol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Reticulin
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46. Delaney D, Diss TC, Presneau N, Hing S, Berisha F, Idowu BD, O'Donnell P, Skinner JA, Tirabosco R, Flanagan AM: GNAS1 mutations occur more commonly than previously thought in intramuscular myxoma. Mod Pathol; 2009 May;22(5):718-24
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  • Mutation detection plays an important role in diagnostic pathology, not only in providing a tissue diagnosis, but also in predicting response to antitumourigenic agents.
  • Intramuscular myxoma is a rare benign soft tissue neoplasm that occurs sporadically and less commonly in association with fibrous dysplasia (Mazabraud's syndrome).
  • Mutations were detected in two cases where a diagnosis of low-grade myxofibrosarcoma had been favoured over intramuscular myxoma.
  • [MeSH-major] GTP-Binding Protein alpha Subunits, Gs / genetics. Myxoma / genetics. Polymerase Chain Reaction / methods. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Cold Temperature. DNA Mutational Analysis. Diagnosis, Differential. Fibrosarcoma / genetics. Fibrosarcoma / pathology. Humans. Mutation. Sensitivity and Specificity

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  • (PMID = 19287459.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.6.1.- / GNAS protein, human; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gs
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47. Hsieh TJ, Wang CK, Tsai KB, Chen YW: Pilomatricoma: magnetic resonance imaging and pathological evaluation. J Comput Assist Tomogr; 2008 Mar-Apr;32(2):320-3
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  • Pilomatricoma is an asymptomatic, slowly growing, benign skin tumor that is typically located in the regions of head and neck.
  • Our case revealed late enhancement in the dynamic magnetic resonance imaging study that is a common pattern more in a benign soft tissue tumor and caused dramatic uptake in the bone scintigraphy.
  • [MeSH-major] Hair Diseases / diagnosis. Magnetic Resonance Imaging / methods. Pilomatrixoma / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 18379325.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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48. Friedrich C, Holtkamp N, Cinatl J Jr, Sakuma S, Mautner VF, Wellman S, Michaelis M, Henze G, Kurtz A, Driever PH: Overexpression of Midkine in malignant peripheral nerve sheath tumor cells inhibits apoptosis and increases angiogenic potency. Int J Oncol; 2005 Nov;27(5):1433-40
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  • [Title] Overexpression of Midkine in malignant peripheral nerve sheath tumor cells inhibits apoptosis and increases angiogenic potency.
  • Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue tumors arising sporadically although more frequently in patients with Neurofibromatosis type 1.
  • The heparin-binding growth factor, Midkine (MK), is implicated in the tumorigenesis of benign and plexiform neurofibromas, and thereof arising MPNSTs.
  • Yet, stable overexpression of MK in S462 as well as in ST88-14 cells was not sufficient to promote xenograft tumor growth in nude mice.
  • [MeSH-major] Apoptosis / physiology. Cytokines / biosynthesis. Neovascularization, Pathologic / pathology. Nerve Sheath Neoplasms / genetics
  • [MeSH-minor] Animals. Cell Survival. Humans. Mice. Mice, Nude. Polymorphism, Single-Stranded Conformational. Reverse Transcriptase Polymerase Chain Reaction. Transfection. Transplantation, Heterologous. Tumor Cells, Cultured. Up-Regulation

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  • (PMID = 16211240.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Cytokines; 137497-38-2 / midkine
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49. Breuer C, Paul H, Zimmermann A, Braunstein S, Schaper J, Mayatepek E, Oh J: Mandibular aneurysmal bone cyst in a child misdiagnosed as acute osteomyelitis: a case report and a review of the literature. Eur J Pediatr; 2010 Aug;169(8):1037-40
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  • [Title] Mandibular aneurysmal bone cyst in a child misdiagnosed as acute osteomyelitis: a case report and a review of the literature.
  • The aneurysmal bone cyst is a very infrequent, benign bone lesion in children which rarely can be found at the craniofacial skeleton.
  • The cause of misleading diagnosis is often owing to the rapid growth of the lesion, sometimes associated with painful soft tissue swelling indicating an infectious origin or a malignant tumor.
  • Therefore, curative tumor embolization and complete surgical excision was successfully performed.
  • [MeSH-major] Bone Cysts, Aneurysmal / diagnosis. Diagnostic Errors. Magnetic Resonance Imaging. Mandible / pathology. Mandibular Diseases / diagnosis. Osteomyelitis / diagnosis
  • [MeSH-minor] Acute Disease. Child. Diagnosis, Differential. Embolization, Therapeutic. Humans

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  • (PMID = 20107833.001).
  • [ISSN] 1432-1076
  • [Journal-full-title] European journal of pediatrics
  • [ISO-abbreviation] Eur. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
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50. Dreux N, Marty M, Chibon F, Vélasco V, Hostein I, Ranchère-Vince D, Terrier P, Coindre JM: Value and limitation of immunohistochemical expression of HMGA2 in mesenchymal tumors: about a series of 1052 cases. Mod Pathol; 2010 Dec;23(12):1657-66
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  • The high mobility group A (HMGA2) gene encodes a protein that alters chromatin structure and regulates the transcription of many genes; it is implicated in both benign and malignant neoplasias, but its rearrangements are a feature of development of several mesenchymal tumors.
  • Given its implication in these tumors and particularly adipocytic tumors, and the availability of antibodies usable on paraffin-embedded tissues, we evaluated the immunohistochemical expression of this gene in a series of 1052 mesenchymal tumors.
  • We thus analyzed 880 cases on tissue microarray and 182 cases on whole sections (211 adipocytic tumors, 628 sarcomas, 213 benign mesenchymal tumors, and 10 normal adipose tissues).
  • A nuclear immunostaining was detected in 86% of conventional and intramuscular lipomas, in 86% of well-differentiated liposarcomas and in 67% of dedifferentiated liposarcomas, as opposed to 16% of other benign adipose tumors and to 15% of non-well-differentiated liposarcoma/dedifferentiated liposarcoma sarcomas.
  • Among benign mesenchymal tumors and lesions, it was detected in 90% of nodular fasciitis and in 88% of benign fibrous histiocytomas with respective specificities of 85 and 100%, and in 90% of aggressive angiomyxoma, contrary to other vulvovaginal tumor types, which expressed HMGA2 only rarely.
  • The normal adipose tissue was always negative for HMGA2.
  • Although not specific, immunohistochemical detection of the HMGA2 protein is helpful for the distinction of normal adipose tissue from well-differentiated lesions, particularly on biopsy or on re-excision.
  • It is less sensitive than MDM2/CDK4 for dedifferentiated liposarcomas diagnosis, but it appears more specific to distinguish dedifferentiated liposarcomas from other poorly differentiated sarcomas.
  • Finally, and may be more importantly, HMGA2 is useful for the diagnosis of benign fibrous histiocytoma, nodular fasciitis and vulvovaginal benign mesenchymal tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. HMGA2 Protein / biosynthesis. Neoplasms, Connective and Soft Tissue / diagnosis. Neoplasms, Connective and Soft Tissue / metabolism
  • [MeSH-minor] Humans. Immunohistochemistry. Tissue Array Analysis

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  • (PMID = 20834238.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / HMGA2 Protein
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51. Billings SD, Giblen G, Fanburg-Smith JC: Superficial low-grade fibromyxoid sarcoma (Evans tumor): a clinicopathologic analysis of 19 cases with a unique observation in the pediatric population. Am J Surg Pathol; 2005 Feb;29(2):204-10
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  • [Title] Superficial low-grade fibromyxoid sarcoma (Evans tumor): a clinicopathologic analysis of 19 cases with a unique observation in the pediatric population.
  • Low-grade fibromyxoid sarcoma (LGFMS), usually a deeply situated mass in adults, is uncommon in superficial soft tissue and in children.
  • Nineteen superficial LGFMS from our files were studied for clinicopathologic features, the latter including tumor size, growth pattern, cellularity, collagen rosettes, vascularity, nuclear atypia, mitotic rate, necrosis, and immunophenotype.
  • Tumor locations included the lower extremity (8), buttock (3), trunk (3), vulva/inguinal region (2), upper extremity (2), and unspecified subcutis (1).
  • Clinical and histologic submitting diagnoses were mainly benign except for 3 cases, submitted as low-grade sarcoma, with only one as superficial LGFMS.
  • The mean tumor size was 4.2 cm (range, 1.6-18 cm).
  • Of 15 with evaluable resections, 5 had focal ink on tumor and 2 of these had known negative wider reexcisions.
  • Tumor cells were positive for vimentin and some were focally positive for actins, CD68, and EMA.
  • [MeSH-major] Fibroma / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 15644777.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. Dohi O, Ohtani H, Hatori M, Sato E, Hosaka M, Nagura H, Itoi E, Kokubun S: Histogenesis-specific expression of fibroblast activation protein and dipeptidylpeptidase-IV in human bone and soft tissue tumours. Histopathology; 2009 Oct;55(4):432-40
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  • [Title] Histogenesis-specific expression of fibroblast activation protein and dipeptidylpeptidase-IV in human bone and soft tissue tumours.
  • They are involved in tissue remodelling, cancer invasion and metastases, mechanisms that are controversial.
  • The aim was to identify cell types that express FAP and DPP-IV in human bone and soft tissue tumours, and to determine whether there are any correlations between the expression of FAP and DPP-IV and the malignant potential of tumours.
  • METHODS AND RESULTS: This study analysed in situ expression in 25 malignant and 13 benign human bone and soft tissue tumours.
  • Among benign tumours, non-ossifying fibromas, desmoid tumours and chondroblastomas expressed both FAP and DPP-IV.
  • CONCLUSIONS: Our data suggest that FAP and DPP-IV are consistently expressed in bone and soft tissue tumour cells that are histogenetically related to activated fibroblasts and/or myofibroblasts, irrespective of their malignancy.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Bone Neoplasms / metabolism. Bone Neoplasms / pathology. Dipeptidyl Peptidase 4 / metabolism. Gelatinases / metabolism. Membrane Proteins / metabolism. Serine Endopeptidases / metabolism. Soft Tissue Neoplasms / metabolism. Soft Tissue Neoplasms / pathology

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  • (PMID = 19817894.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Proteins; EC 3.4.14.5 / Dipeptidyl Peptidase 4; EC 3.4.21.- / Serine Endopeptidases; EC 3.4.21.- / fibroblast activation protein alpha; EC 3.4.24.- / Gelatinases
  • [Other-IDs] NLM/ PMC2784039
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53. Yu H, Wang CF, Yang WT, Zhu XZ: [Angiomatoid fibrous histiocytoma: report of 5 cases with review of literature]. Zhonghua Bing Li Xue Za Zhi; 2010 Apr;39(4):245-8
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  • OBJECTIVE: To study the clinicopathologic features, immunophenotype and differential diagnosis of angiomatoid fibrous histiocytoma (AFH).
  • The patients underwent complete resection of the tumor, with no adjuvant chemotherapy and/or radiotherapy given.
  • Gross examination showed that the tumor was well-circumscribed and had a grey-colored cut surface, with focal hemorrhagic cystic changes.
  • The average tumor dimension was 1.9 cm.
  • Histologically, the tumor was composed of histiocytoid or spindly cells arranged in nodular pattern.
  • Fibrillary neuropil-type intercellular material was identified in all cases and a fibrous pseudocapsule surrounded by lymphocytes and plasma cells was demonstrated in 3 cases.
  • CONCLUSIONS: AFH is a rare tumor of intermediate malignant potential.
  • Definitive diagnosis requires thorough histologic examination and clinical correlation.
  • Immunohistochemistry is also helpful for diagnosis and differential diagnosis.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aneurysm / metabolism. Aneurysm / pathology. Antigens, CD / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Chemotherapy, Adjuvant. Child. Desmin / metabolism. Diagnosis, Differential. Female. Follow-Up Studies. Histiocytoma, Malignant Fibrous / pathology. Humans. Male. Radiotherapy, Adjuvant. Vimentin / metabolism. Young Adult

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  • (PMID = 20654123.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / Desmin; 0 / Vimentin
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54. Schittenhelm J, Ebner FH, Harter P, Bornemann A: Symptomatic intraspinal oncocytic adrenocortical adenoma. Endocr Pathol; 2009;20(1):73-7
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  • Most intraspinal neoplasms of epithelial origin are metastases from primary carcinomas.
  • Benign epithelial tumors are rarely found at this site.
  • We here present the case of a 44-year-old woman with a lesion in the cauda equina that fulfilled the radiologic criteria of schwannoma and caused clinical symptoms for 3 years.
  • The excised tumor was composed of nests of large polygonal cells with eosinophilic partial granular cytoplasm.
  • The tumor showed diffuse positivity for melan-A, synaptophysin, and alpha-inhibin.
  • Ultrastructural examination showed abundant mitochondria, suggesting an oncocytic tumor.
  • The diagnosis of an oncocytic adrenal cortical adenoma was made.
  • These extraadrenal tumors are thought to arise from heterotopic adrenocortical tissue in the spinal cavity.
  • Oncocytic tumors are rare neoplasms and they comprise non-functioning variants of adrenal cortical adenomas.
  • Immunohistochemistry excluded oncocytic paraganglioma, oncocytic meningioma, renal cell carcinoma, alveolar soft part sarcoma, and granular cell tumor.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Adrenocortical Adenoma / pathology. Spinal Cord Neoplasms / pathology

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  • (PMID = 19039533.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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55. Fritz MA, Sade B, Bauer TW, Wood BG, Lee JH: Benign fibrous histiocytoma of the pterygopalatine fossa with intracranial extension. Acta Neurochir (Wien); 2006 Jan;148(1):73-6; discussion 76
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  • [Title] Benign fibrous histiocytoma of the pterygopalatine fossa with intracranial extension.
  • Despite the histologic absence of nuclear pleomorphism, the tumor rapidly recurred after complete surgical resection.
  • The aggressive nature of our patient's tumor confirms previous observations that an aggressive radiographic appearance has prognostic value when dealing with skeletal and soft tissue tumors.
  • [MeSH-major] Brain / pathology. Histiocytoma, Benign Fibrous / pathology. Neoplasm Recurrence, Local / pathology. Palate, Hard. Skull Base Neoplasms / pathology
  • [MeSH-minor] Fatal Outcome. Humans. Male. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 16200478.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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56. Liu XM, Wang WC, Liu MH, Zhou QC: [Diagnostic value of 2-dimentional ultrasonography and color Doppler flow imaging in primary bone tumor]. Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2006 Jun;31(3):420-3
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  • [Title] [Diagnostic value of 2-dimentional ultrasonography and color Doppler flow imaging in primary bone tumor].
  • OBJECTIVE: To explore the diagnostic value of 2-dimentional ultrasonography and color Doppler flow imaging (CDFI) in primary bone tumor.
  • RESULTS: The bone destruction periosteum response and soft tissue mass were essentially revealed with 2-dimentional ultrasonography techniques.
  • The Vmax and Vmin in malignant bone tumor were significantly higher than those in benign one (P < 0.01).
  • RI and PI in malignant bone tumor were lower than those in benign one (P < 0.01).
  • CONCLUSION: Observing the features of bone tumor and hemodynamic parameters by 2-dimentional ultrasonography and CDFI has a great clinical value in diagnosing primary bone tumor and distinguishing the malignant and benign bone tumors.
  • [MeSH-major] Bone Neoplasms / ultrasonography. Osteosarcoma / ultrasonography. Ultrasonography, Doppler, Color / methods
  • [MeSH-minor] Adolescent. Adult. Blood Flow Velocity. Female. Giant Cell Tumor of Bone / ultrasonography. Humans. Male. Middle Aged. Ultrasonography, Doppler, Duplex / methods

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  • (PMID = 16859139.001).
  • [ISSN] 1672-7347
  • [Journal-full-title] Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
  • [ISO-abbreviation] Zhong Nan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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57. Kaddoura I, Zaatari G: Fibro-osseous pseudotumor of the thenar eminence: a rare aggressive but benign tumor. Ann Plast Surg; 2009 Mar;62(3):326-8
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  • [Title] Fibro-osseous pseudotumor of the thenar eminence: a rare aggressive but benign tumor.
  • Fibro-osseous pseudotumor is a rare benign lesion that is characterized by fibroblastic proliferation with foci of osseous differentiation.
  • The tumor commonly involves the digits and is usually mistaken for malignancy because of its aggressive nature thus resulting in surgical over treatment.
  • [MeSH-major] Soft Tissue Neoplasms / pathology

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  • (PMID = 19240534.001).
  • [ISSN] 1536-3708
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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58. Linke R, Kuwert T, Uder M, Forst R, Wuest W: Skeletal SPECT/CT of the peripheral extremities. AJR Am J Roentgenol; 2010 Apr;194(4):W329-35
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  • OBJECTIVE: Hybrid cameras that combine SPECT and helical CT can be used to correlate scintigraphic information with morphologic information in one imaging session.
  • Planar scintigraphic and SPECT images and planar scintigraphic and SPECT/CT images were interpreted independently from each other.
  • The findings were classified into the following diagnostic categories: normal, trauma, tumor, osteomyelitis, and osteoarthritis.
  • RESULTS: Four patients had no abnormal bone metabolism or CT abnormality in the extremities.
  • Among 34 lesions classified as osteoarthritis on planar and SPECT images, seven were reclassified as fracture and one as benign tumor at SPECT/CT.
  • Of 15 lesions initially classified as osteomyelitis, four were diagnosed as osteoarthritis, four as fracture, and one as inflammation of the soft tissue only.
  • In one of 10 patients with the initial diagnosis of a tumorlike lesion, the diagnosis was changed to trauma on the basis of SPECT/CT findings, and in another patient, the diagnosis was changed to osteoarthritis.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Bone Neoplasms / radiography. Bone Neoplasms / radionuclide imaging. Chi-Square Distribution. Child. Diphosphonates. Female. Gamma Cameras. Humans. Male. Middle Aged. Osteoarthritis / radiography. Osteoarthritis / radionuclide imaging. Osteomyelitis / radiography. Osteomyelitis / radionuclide imaging. Radiographic Image Interpretation, Computer-Assisted. Radiopharmaceuticals. Technetium Compounds. Wounds and Injuries / radiography. Wounds and Injuries / radionuclide imaging

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  • (PMID = 20308478.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Diphosphonates; 0 / Radiopharmaceuticals; 0 / Technetium Compounds; 8V3FGC4J77 / technetium Tc 99m diphosphonate
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59. Blum A, Back W, Naim R, Hörmann K, Riedel F: Ossifying fibromyxoid tumor of the nasal septum. Auris Nasus Larynx; 2006 Sep;33(3):325-7
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  • [Title] Ossifying fibromyxoid tumor of the nasal septum.
  • The fibromyxoid tumor is quite a rare soft tissue tumor and typically presents as an ossifying fibromyxoid tumor (OFMT) in the subcutis of the extremities of adults.
  • We present a case of a fibromyxoid tumor of the nasal septum in a 49-year-old female who complained of nasal airway obstruction and enlargement of the right contour of the nose.
  • Endonasal, endoscopic tumor excision was performed.
  • The tumor contained spindle-shaped and polygonal cells, mucoid pseudocysts and a fibromyxoid stroma with local calcifications.
  • The clinical behaviour of OFMT in general is benign but some reports have documented atypical tumors with histologic signs of malignancy.
  • [MeSH-major] Fibroma, Ossifying / surgery. Nasal Septum / pathology. Nose Neoplasms / surgery

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  • (PMID = 16600550.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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60. Adachi S, Doi R, Mitani K, Iwamoto Y, Furumoto A, Yamashita M, Cho H: Atypical soft tissue perineurioma in the tongue of a young girl. Pathol Int; 2010 Dec;60(12):787-91
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  • [Title] Atypical soft tissue perineurioma in the tongue of a young girl.
  • Perineuriomas are uncommon benign peripheral nerve sheath tumors that include soft tissue, sclerosing, reticular, and intraneural variants.
  • Soft tissue perineuriomas arise in a wide anatomic distribution and mostly in patients older than 20 years of age.
  • The tumor, located in the tongue, was uniformly hypercellular.
  • The tumor cells were spindle-shaped with a slender, elongated, bipolar, wavy cytoplasmic process formation and wavy elongated nuclei, and the architecture was composed of predominantly short fascicles with areas exhibiting a vague storiform pattern.
  • Although the tumor cells generally appeared bland, the tumor showed worrisome features including an infiltrative pattern and occasional mitotic figures.
  • Psammoma bodies were observed in the periphery of the tumor.
  • The authors document a case of soft tissue perineurioma with atypical histological features that occurred in the tongue of a child.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Child. Female. Humans. Immunohistochemistry. Soft Tissue Neoplasms / metabolism. Soft Tissue Neoplasms / pathology

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  • [Copyright] © 2010 The Authors. Pathology International © 2010 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.
  • (PMID = 21091838.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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61. Okubo H, Ozeki K, Tanaka T, Matsuo T, Mochinaga N: Primary malignant fibrous histiocytoma of the ascending colon: report of a case. Surg Today; 2005;35(4):323-7
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  • [Title] Primary malignant fibrous histiocytoma of the ascending colon: report of a case.
  • A 66-year-old man presented to our hospital with epigastralgia, and abdominal ultrasonography and computed tomography showed a large soft-tissue mass in the ascending colon.
  • Barium enema and endoscopic examination showed a huge tumor in the ascending colon.
  • At laparotomy, we found a tumor in the ascending colon and performed a right hemicolectomy with en bloc lymph node dissection.
  • The resected specimen contained a tumor measuring 14.5 x 8.0 x 4.5 cm, the cut surface of which was yellowish.
  • Based on histological and immunohistological studies, the tumor was diagnosed as MFH of the ascending colon.
  • [MeSH-major] Colon, Ascending. Colonic Neoplasms / surgery. Histiocytoma, Benign Fibrous / surgery
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male

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  • (PMID = 15815852.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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62. Lipira AB, Kasukurthi R, Ray WZ, Pruzansky ME, Mackinnon SE: Intraneural synovial sarcoma of the median nerve. Rare Tumors; 2010;2(2):e32
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  • Synovial sarcomas are soft-tissue malignancies with a poor prognosis and propensity for distant metastases.
  • Because the diagnosis may not be apparent until after pathological examination of the surgical specimen, synovial sarcoma should be kept in mind when dealing with what may seem like a benign nerve tumor.

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  • (PMID = 21139834.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994501
  • [Keywords] NOTNLM ; intraneural synovial sarcoma / median nerve.
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63. Ochalski PG, Edinger JT, Horowitz MB, Stetler WR, Murdoch GH, Kassam AB, Engh JA: Intracranial angiomatoid fibrous histiocytoma presenting as recurrent multifocal intraparenchymal hemorrhage. J Neurosurg; 2010 May;112(5):978-82
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  • Angiomatoid fibrous histiocytoma (AFH) is a rare soft-tissue neoplasm that most commonly appears in the limbs, typically affecting children and young adults.
  • The tumor has a propensity for local recurrence and recurrent hemorrhage but rarely for remote metastasis.
  • To date, only 2 reports have documented an intracranial occurrence of the tumor (1 of which was believed to be metastatic disease).
  • In this report, the authors describe the case of a patient with recurrent hemorrhage due to primary multifocal intracranial AFH.
  • Initially misdiagnosed as a cavernous malformation and then an unusual meningioma, the tumor was finally correctly identified when there was a large enough intact resection specimen to reveal the characteristic histological pattern.
  • The diagnosis was confirmed using immunohistochemical and molecular studies.
  • [MeSH-major] Angiomatosis / complications. Angiomatosis / pathology. Cerebral Hemorrhage / complications. Cerebral Hemorrhage / pathology. Histiocytoma, Benign Fibrous / complications. Histiocytoma, Benign Fibrous / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Recurrence. Young Adult

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  • (PMID = 19731989.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Sarikcioglu L, Demirel BM, Ozsoy U, Gurer EI, Oguz N, Ucar Y: Angiolipoma located inside the obturator canal and supplied by the umbilical artery. Ann Anat; 2007;189(1):75-8
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  • During dissection of the retropubic region of a 55-year-old female cadaver, we encountered an angiolipoma located inside the obturator canal which was connected to the wall of the urinary bladder by a fibrous cord.
  • Microscopically the benign soft tissue tumor was characterized by lobules of mature adipocytes and densely distributed networks of small and larger blood vessels, thus resembling typical histological features of an angiolipoma.

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  • (PMID = 17319612.001).
  • [ISSN] 0940-9602
  • [Journal-full-title] Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft
  • [ISO-abbreviation] Ann. Anat.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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65. Lietman SA: Soft-tissue sarcomas: Overview of management, with a focus on surgical treatment considerations. Cleve Clin J Med; 2010 Mar;77 Suppl 1:S13-7
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  • [Title] Soft-tissue sarcomas: Overview of management, with a focus on surgical treatment considerations.
  • Patients with soft-tissue sarcomas generally present with a mass that is increasing in size; the presence or absence of pain is not typically predictive of malignancy.
  • While magnetic resonance imaging (MRI) can identify a few soft-tissue lesion types as benign, diagnosis of most lesions requires a careful biopsy, preferably performed by or in consultation with the surgeon who would do an eventual resection.
  • If biopsy confirms a diagnosis of sarcoma, MRI-guided surgical resection with a wide margin is the mainstay of treatment.

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  • (PMID = 20179181.001).
  • [ISSN] 1939-2869
  • [Journal-full-title] Cleveland Clinic journal of medicine
  • [ISO-abbreviation] Cleve Clin J Med
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 16
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66. Seemann MD, Meisetschlaeger G, Gaa J, Rummeny EJ: Assessment of the extent of metastases of gastrointestinal carcinoid tumors using whole-body PET, CT, MRI, PET/CT and PET/MRI. Eur J Med Res; 2006 Feb 21;11(2):58-65
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  • MATERIALS AND METHODS: This prospective study included six patients with extensive nonresectable metastases of gastrointestinal carcinoid tumors which were consecutively examined from the base of the skull to the proximal thigh using a state-of-the-art PET/CT scanner and a 1.5 Tesla whole-body MRI scanner.
  • MRI was performed with a coronal T2-weighted Half-Fourier Acquired Single-Shot Turbo Spin Echo (HASTE) sequence, a coronal T2-weighted Turbo-Short Tau Inversion-Recovery (STIR) sequence, a coronal T1-weighted Turbo Spin Echo (TSE) sequence and a high resolution axial T2-weighted TSE sequence.
  • Lesions were rated as metastases if they were not clearly identified as benign lesions according to standard radiological criteria.
  • Whole-body PET/MRI is a very promising diagnostic modality for oncological imaging due to the missing radiation exposure and the high soft tissue resolution of MRI in contrast to CT.
  • [MeSH-major] Carcinoid Tumor / pathology. Gastrointestinal Neoplasms / pathology. Magnetic Resonance Imaging. Neoplasm Metastasis. Positron-Emission Tomography. Tomography, X-Ray Computed. Whole Body Imaging
  • [MeSH-minor] Aged. Female. Humans. Image Processing, Computer-Assisted. Male. Middle Aged. Neoplasm Staging. Prospective Studies

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  • (PMID = 16504962.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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67. Al-Otaibi M, Lach B, Al Shail E: December 2004: one-year-old girl with aggressive skull tumor. Brain Pathol; 2005 Apr;15(2):171-3
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  • [Title] December 2004: one-year-old girl with aggressive skull tumor.
  • December 2004. Twelve-month old girl presented with recurrent subcutaneous lesion in the left parietal region, one year after excision of a "benign" tumor.
  • An MRI demonstrated left temporo-parietal skull tumor infiltrating the soft tissue, surrounding craniotomy flap, and extending to the brain parenchyma.
  • Biopsy revealed biphasic neoplasm displaying nests of poorly differentiated neuroblastic cells positive for synaptophysin and pigmented cuboidal epithelioid cell positive for keratins, epithelial membrane antigen and MHB-45.
  • Interestingly, cell with the neuroblastic immunophenotype displayed 80% nuclear MIB-1 reactivity indicating that the aggressiveness of the neoplasm was confined mostly to this pattern of differentiation.
  • The overall histological features are consistent with a rare malignant variant of a melanotic neuroectodermal tumor of infancy.
  • [MeSH-major] Neoplasm Recurrence, Local / pathology. Neuroectodermal Tumor, Melanotic / pathology. Parietal Bone / pathology. Skull Neoplasms / pathology
  • [MeSH-minor] Brain Neoplasms / secondary. Diagnosis, Differential. Fatal Outcome. Female. Humans. Immunohistochemistry. Infant. Magnetic Resonance Imaging. Soft Tissue Neoplasms / secondary. Tomography, X-Ray Computed

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  • (PMID = 15912891.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
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68. Miettinen M, Fetsch JF: Reticulohistiocytoma (solitary epithelioid histiocytoma): a clinicopathologic and immunohistochemical study of 44 cases. Am J Surg Pathol; 2006 Apr;30(4):521-8
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  • Reticulohistiocytoma and multicentric reticulohistiocytosis are designations for uncommon, incompletely characterized histiocytic proliferations of the skin or soft tissues.
  • SEH is a benign, probably reactive, histiocytic proliferation of unknown etiology.
  • It needs to be distinguished from Rosai-Dorfman disease, juvenile xanthogranuloma, a variety of granulomatous conditions, and some malignant neoplasms, including histiocytic sarcoma, melanoma, and epithelioid sarcoma.
  • [MeSH-major] Epithelioid Cells / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Biomarkers, Tumor / metabolism. Child. Child, Preschool. Diagnosis, Differential. Female. Histiocytoma, Malignant Fibrous / diagnosis. Histiocytosis, Sinus / diagnosis. Humans. Male. Middle Aged. Sarcoma / diagnosis. Sex Distribution. Xanthogranuloma, Juvenile / diagnosis

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  • (PMID = 16625100.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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69. Kazakov DV, Sima R, Michal M: Hemosiderotic fibrohistiocytic lipomatous lesion: clinical correlation with venous stasis. Virchows Arch; 2005 Jul;447(1):103-6
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  • HFLL was originally suggested to be a benign reactive lesion arising due to an antecedent trauma.
  • We hypothesize that the proliferation of spindled fibroblastic and myofibroblastic cells and capillaries, erythrocyte extravasation, and hemosiderin deposition with lipomatous tissue of HFLL may simply represent an exaggerated tissue response to venous stasis in which elevated venous and capillary pressures, oxygen saturation, and edema stimulate the proliferation of the above mentioned elements and lead to erythrocyte extravasation.
  • [MeSH-major] Hemosiderosis / pathology. Histiocytosis / pathology. Lipoma / pathology. Soft Tissue Neoplasms / pathology. Varicose Veins / pathology. Venous Insufficiency / pathology
  • [MeSH-minor] Adipose Tissue / chemistry. Adipose Tissue / pathology. Biomarkers, Tumor / analysis. Female. Hemosiderin / analysis. Humans. Immunohistochemistry. Middle Aged. Treatment Outcome

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  • (PMID = 15947948.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 9011-92-1 / Hemosiderin
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70. Iascone C, Sadighi A, Ruperto M, Paliotta A, Borrini F, Mingazzini P: Pleomorphic hyalinizing angiectatic tumour of the mesorectal soft tissue. A case report and review of the literatre. Chir Ital; 2008 Jan-Feb;60(1):159-63
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  • [Title] Pleomorphic hyalinizing angiectatic tumour of the mesorectal soft tissue. A case report and review of the literatre.
  • Pleomorphic hyalinizing angiectatic tumours are rare stromal lesions histologically resembling both neurilemoma and malignant fibrous histiocytoma and occurring in the subcutaneous soft tissue of the lower and upper limbs and, less frequently, in the chest wall.
  • The case reported here is one of 22 cases published in the medical literature and describes a pleomorphic hyalinizing angiectatic tumour which was localized in a body cavity and developed in the pelvis.
  • The lesion arising from the left mesorectal tissue was entirely resected.
  • [MeSH-major] Rectal Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Incidental Findings. Middle Aged. Neoplasm Proteins / analysis. Neurilemmoma / diagnosis. Prognosis. Stromal Cells / pathology. Tomography, X-Ray Computed. Vimentin / analysis

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  • (PMID = 18389762.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Vimentin
  • [Number-of-references] 15
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71. Yasumoto M, Katada Y, Matsumoto R, Adachi A, Kaneko K: Soft-tissue perineurioma of the retroperitoneum in a 63-year-old man, computed tomography and magnetic resonance imaging findings: a case report. J Med Case Rep; 2010;4:290
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  • [Title] Soft-tissue perineurioma of the retroperitoneum in a 63-year-old man, computed tomography and magnetic resonance imaging findings: a case report.
  • INTRODUCTION: Soft-tissue perineuriomas are rare benign peripheral nerve sheath tumors in the subcutis of the extremities and the trunks of young patients.
  • To our knowledge, this the first presentation of the computed tomography and magnetic resonance imaging of a soft-tissue perineurioma in the retroperitoneum with pathologic correlation.
  • Abdominal computed tomography and magnetic resonance imaging showed a well-defined, gradually enhancing tumor without focal degeneration or hemorrhage adjacent to the pancreatic body.
  • Tumor excision with distal pancreatectomy and splenectomy was performed, as a malignant tumor of pancreatic origin could not be ruled out.
  • Pathologic examination of the tumor revealed a soft-tissue perineurioma of the retroperitoneum.
  • CONCLUSION: Although the definitive diagnosis of soft-tissue perineurioma requires biopsy and immunohistochemical reactivity evaluation, the computed tomography and magnetic resonance imaging findings described in this report suggest inclusion of this rare tumor in the differential diagnosis when such findings occur in the retroperitoneum.

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  • (PMID = 20738883.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2936321
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72. Erdas E, Licheri S, Pinna G, Gerosa C, Ragazzo G: [Elastofibroma dorsi: case report and review of the literature]. G Chir; 2006 Oct;27(10):372-6
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  • [Transliterated title] L'elastofibroma dorsi: descrizione di un caso clinico e analisi della letteratura.
  • Elastofibroma dorsi (ED) is a rare, benign, often bilateral lesion of the thoracic wall, occurring most commonly in the infra-scapular region beneath the muscular tissue, generally found in elderly women.
  • Whether ED should be considered as a true neoplasm or merely as a reaction of connective tissue to repetitive minor trauma is still debated.
  • ED has characteristic features but a low incidence and is therefore not always easily distinguished from other benign and malignant soft-tissue tumors.
  • Inappropriate treatment may thus be administrated in the absence of a definitive diagnosis.
  • We report a case of a 51-year-old woman who presented with a right infra-scapular swelling associated with pain and a clicking sensation during selective arm movements.
  • Upon clinical and ultrasound examination, the lesion had the appearance of a deep dorsal lipoma, but intraoperative findings were suggestive of a sarcoma originating from the periosteum of ribs.
  • Nonetheless, marginal surgical excision was performed and the tumor was histologically diagnosed as ED.
  • In conclusion, ED should be always considered in the differential diagnosis of tumors deeply located in the infra-scapular area, especially in elderly women.
  • As it is a benign lesion, surgical treatment is recommended only in symptomatic cases or if a large swelling is present.
  • [MeSH-major] Elastic Tissue / pathology. Fibroma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Scapula. Treatment Outcome

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  • (PMID = 17147850.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 28
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73. Chen CY, Chiou HJ, Chou YH, Chiou SY, Wang HK, Chou SY, Chiang HK: Computer-aided diagnosis of soft tissue tumors on high-resolution ultrasonography with geometrical and morphological features. Acad Radiol; 2009 May;16(5):618-26
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  • [Title] Computer-aided diagnosis of soft tissue tumors on high-resolution ultrasonography with geometrical and morphological features.
  • RATIONALE AND OBJECTIVES: The aim of this study was to develop a semi-automated computer-aided diagnosis (CAD) system based on high-resolution ultrasonography for classifying benign and malignant soft tissue tumors (STTs).
  • MATERIALS AND METHODS: One hundred seven patients with STTs (70 benign and 37 malignant) were enrolled, and regions of interest were manually delineated for analysis.
  • Sixteen tumor shape features, including five geometric features and 11 morphologic features (six old and five new normalized radial length [NRL] features) were individually evaluated using Student's t test and the area under the receiver-operating characteristic curve (A(z)).
  • CONCLUSION: This semi-automated CAD method based on tumor shape features can successfully distinguish between benign and malignant STTs.
  • It can also provide a second opinion to ultrasound for the diagnosis of STTs.
  • [MeSH-major] Artificial Intelligence. Image Enhancement / methods. Image Interpretation, Computer-Assisted / methods. Imaging, Three-Dimensional / methods. Pattern Recognition, Automated / methods. Soft Tissue Neoplasms / ultrasonography

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  • (PMID = 19345903.001).
  • [ISSN] 1878-4046
  • [Journal-full-title] Academic radiology
  • [ISO-abbreviation] Acad Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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74. Diniz MB, Giro Elisa MA, Zuanon Angela CC, Costa CA, Hebling J: Congenital epulis: a rare benign tumor in the newborn. J Indian Soc Pedod Prev Dent; 2010 Jul-Sep;28(3):230-3
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  • [Title] Congenital epulis: a rare benign tumor in the newborn.
  • Congenital epulis (CE) of the newborn is a rare benign soft tissue tumor that presents at birth.
  • A decisive diagnosis is made by histopathologic analysis as other newborn lesions can be incorrectly diagnosed as CE.
  • This article presents a case report of a female infant who presented a fibrotic mass in the primary lateral incisor and canine region of the maxillary alveolar ridge.
  • [MeSH-major] Gingival Neoplasms / congenital. Gingival Neoplasms / pathology

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  • (PMID = 21157060.001).
  • [ISSN] 0970-4388
  • [Journal-full-title] Journal of the Indian Society of Pedodontics and Preventive Dentistry
  • [ISO-abbreviation] J Indian Soc Pedod Prev Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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75. Osipov V, Carrera GF: Collagenous fibroma (desmoplastic fibroblastoma) with vertebral body erosion. Sarcoma; 2009;2009:682687
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  • Collagenous fibroma (desmoplastic fibroblastoma) is a recently described rare benign tumor affecting mainly males in the fifth through seventh decades.
  • This tumor occurs predominantly in the peripheral sites, with predilection for upper and lower extremities.
  • This tumor should be in the differential diagnosis of the soft tissue lesions presenting with bony erosion.

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  • [Cites] Hum Pathol. 1998 Jul;29(7):676-82 [9670823.001]
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  • (PMID = 19503798.001).
  • [ISSN] 1357-714X
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2688648
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76. Bastian PJ, Fisang C, Schmidt ME, Biermann K, Textor J, Müller SC: Aggressive angiomyxoma of the prostate mimicking benign prostatic hyperplasia. Eur J Med Res; 2006 Apr 28;11(4):167-9
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  • [Title] Aggressive angiomyxoma of the prostate mimicking benign prostatic hyperplasia.
  • Aggressive angiomyxoma (AAM) is a locally invasive soft tissue tumor with a high risk of local recurrence but without metastatic spread.
  • The mesenchymal tumor is relatively site-specific and has a peak incidence in females in their 2nd or 4th decade.
  • We describe what we think is the first case of an aggressive angiomyxoma arising in the prostate presenting with classical symptoms of benign prostatic hyperplasia.
  • [MeSH-major] Myxoma / diagnosis. Prostatic Hyperplasia / diagnosis. Prostatic Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Prostate / pathology. Transurethral Resection of Prostate. Treatment Outcome


77. Tsitouridis I, Michaelides M, Bintoudi A, Kyriakou V: Frontoethmoidal Mucoceles: CT and MRI Evaluation. Neuroradiol J; 2007 Oct 31;20(5):586-96
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  • It is a benign slow growing epithelial lined lesion, bulging against adjacent anatomical structures, without infiltrating them.
  • CT scans displayed mucoceles as non enhancing soft tissue density lesions, generally isodense to the brain parenchyma, expanding the sinuses in most cases, eroding adjacent bones and extending intraorbitally or intracranially.
  • The causes of mucoceles included mucosal thickening from chronic sinusitis, adhesions from previous operation in the nasal cavity, previous trauma, small nasal polyps and a small osteoma, while in six patients (31.5%) the cause of the mucocele remained unrecognized even after surgery.
  • No underlying malignant tumor was found in any of the cases as the cause of obstruction.
  • CT and MRI established the correct diagnosis in all patients.
  • CT was more sensitive in determining bone erosions, while MRI had the advantage of multiplanar imaging and was much more sensitive for differentiating mucocele from a tumor on the basis of MR signal intensity characteristics.

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  • (PMID = 24299951.001).
  • [ISSN] 1971-4009
  • [Journal-full-title] The neuroradiology journal
  • [ISO-abbreviation] Neuroradiol J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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78. Leung TK, Lee CM, Shen LK, Chen YY: Differential diagnosis of cystic lymphangioma of the pancreas based on imaging features. J Formos Med Assoc; 2006 Jun;105(6):512-7
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  • [Title] Differential diagnosis of cystic lymphangioma of the pancreas based on imaging features.
  • Lymphangioma is a benign tumor, which is a consequence of lymphatic malformation with blockage of lymphatic flow.
  • We report the case of a 34-year-old woman with cystic lymphangioma of the pancreas without major symptoms or signs.
  • It is always a challenge to differentiate the lesion from other possible cystic-like pancreatic neoplasms.
  • Differential diagnosis of cystic lymphangioma from other cystic-like tumors of the pancreas can be performed based on their imaging characteristics, including presence of septa, cystic or wall calcification, soft tissue, wall thickness, single or multiple loculation, and dilatation of the pancreatic duct.

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  • (PMID = 16801041.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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79. Müller CS, Tilgen W, Kutzner H, Pföhler C: Recurring mixed-type neurothekeoma of the face. Dermatoendocrinol; 2009 Jul;1(4):220-2
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  • BACKGROUND: Neurothekeomas are rare, benign neoplasms, typically occurring in younger patients with a remarkable predilection for the female population.
  • The rarity of this unusual skin tumor in daily routine histopathologic findings prompted the following report.
  • Multiple treatments with laser surgery were performed and yielded no persistent remission of the tumor.
  • Histopathologic examination revealed a non-encapsulated dermal tumor, composed of multiple, closely situated medium-sized nodules, separated by a myxoid collagenrich stroma, without epidermal alteration.
  • In summary, due to the histoarchitecture and immunoprofile of the tumor, a mixed-type cellular neurothekeoma was diagnosed.
  • CONCLUSION: We think that it is important to be aware of these uncommon soft tissue lesions and the pitfalls of mixed-type neurothekeomas that often cause diagnostic problems.

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  • [Cites] Histopathology. 1998 May;32(5):414-22 [9639116.001]
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  • (PMID = 20592794.001).
  • [ISSN] 1938-1980
  • [Journal-full-title] Dermato-endocrinology
  • [ISO-abbreviation] Dermatoendocrinol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2835878
  • [Keywords] NOTNLM ; cellular / nerve sheath tumor / neurothekeoma / skin / soft tissue tumor
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80. Saleh H, Kapadia R: Aspiration biopsy cytology of extraabdominal desmoid tumor concurrently occurring in a patient with tumoral calcinosis. Diagn Cytopathol; 2008 Sep;36(9):624-7
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  • [Title] Aspiration biopsy cytology of extraabdominal desmoid tumor concurrently occurring in a patient with tumoral calcinosis.
  • Extraabdominal fibromatosis or desmoid tumor (DT) is a slow growing locally aggressive soft tissue tumor that can occur anywhere in the body.
  • We report the aspiration biopsy cytology features of a case of DT of the right neck area in a 35-year-old man who had a long standing history of tumoral calcinosis.
  • The aspirate was interpreted as "benign spindle cell lesion" and confirmed as DT on histologic examination of the resected mass.
  • We discuss the possible differential diagnoses of other benign or malignant lesions on fine-needle aspiration (FNA) biopsy and especially discuss the aspiration cytology features of DT compared with those of tumoral calcinosis.
  • We also discuss the value of immunohistochemical markers that help in differentiating DT from other entities.
  • [MeSH-major] Calcinosis / complications. Fibromatosis, Abdominal / complications. Fibromatosis, Abdominal / pathology. Soft Tissue Neoplasms / complications. Soft Tissue Neoplasms / pathology

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  • (PMID = 18677759.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / beta Catenin
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81. Adachi Y, Horie Y, Kitamura Y, Nakamura H, Taniguchi Y, Miwa K, Fujioka S, Nishimura M, Hayashi K: CD1a expression in PEComas. Pathol Int; 2008 Mar;58(3):169-73
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  • According to the World Health Organization classification, neoplasms with perivascular epithelioid cell differentiation (PEComas) are mesenchymal tumors composed of histologically and immunohistochemically distinctive PEC.
  • Recently the authors reported that benign clear cell sugar tumor of the lung, one of the PEComas, expressed CD1a.
  • Nineteen PEComas were obtained, which included angiomyolipoma of the kidney or liver, lymphangiomyomatosis of the uterus or lung and clear cell sugar tumor of the lung.
  • [MeSH-major] Antigens, CD1 / metabolism. Biomarkers, Tumor / metabolism. Epithelioid Cells / metabolism. Neoplasms, Connective and Soft Tissue / metabolism

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  • (PMID = 18251780.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, CD1; 0 / Biomarkers, Tumor; 0 / CD1a antigen
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82. Rohilla S, Yadav RK, Dhaulakhandi DB: Lipoma of Guyon's canal causing ulnar neuropathy. J Orthop Traumatol; 2009 Jun;10(2):101-3
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  • Lipoma is a benign soft tissue tumor which rarely causes neuropathy.

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  • [Cites] Ann Fr Anesth Reanim. 2008 Jan;27(1):114-5 [18164175.001]
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  • (PMID = 19468684.001).
  • [ISSN] 1590-9921
  • [Journal-full-title] Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology
  • [ISO-abbreviation] J Orthop Traumatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2688595
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83. Patel T, Bansal R, Trivedi P, Modi L, Shah MJ: Subcutaneous metastases of sarcomatoid mesothelioma with its differential diagnosis on fine needle aspiration--a case report. Indian J Pathol Microbiol; 2005 Oct;48(4):482-4
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  • [Title] Subcutaneous metastases of sarcomatoid mesothelioma with its differential diagnosis on fine needle aspiration--a case report.
  • A 25 year old woman, who had undergone chemotherapy, partial excision of tumor followed by radiotherapy of sarcomatoid mesothelioma of the pleura, presented three months later with painless widespread subcutaneous nodules.
  • It is essential to differentiate neoplasm metastatic to the skin and subcutis from primary and benign lesions of the same region.
  • FNAC is accurate and efficient, in conjugation with clinical history, and it also prevents surgical biopsy in the diagnosis of metastatic subcutaneous lesion.
  • To our knowledge, this is the first case, reported till date, in which the sarcomatoid mesothelioma metastasized to the subcutaneous tissue and was diagnosed by fine needle aspiration cytology (FNAC).
  • [MeSH-major] Mesothelioma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Pleural Neoplasms. Skin Neoplasms / diagnosis. Skin Neoplasms / secondary. Subcutaneous Tissue

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  • (PMID = 16366102.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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84. Kim HJ, Baek CH, Ko YH, Choi JY: Neurothekeoma of the tongue: CT, MR, and FDG PET imaging findings. AJNR Am J Neuroradiol; 2006 Oct;27(9):1823-5
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  • We report CT, MR, and fluorodeoxyglucose-positron-emission tomography (FDG-PET) imaging findings of a case of cellular neurothekeoma of the tongue, a rare benign soft-tissue tumor with neural differentiation, occurring in a 15-year-old girl.
  • CT and MR imaging showed a well-defined, well-enhancing submucosal soft-tissue mass in the midline dorsal tongue.
  • Although imaging findings are rather nonspecific, neurothekeoma may be one of diagnostic inclusions of soft-tissue masses of the tongue in a young female patient.
  • [MeSH-major] Fluorodeoxyglucose F18. Magnetic Resonance Imaging. Neurothekeoma / diagnosis. Positron-Emission Tomography. Tomography, X-Ray Computed. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Biomarkers, Tumor / analysis. Blood Glucose / metabolism. Female. Humans. Tongue / pathology

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  • (PMID = 17032850.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Blood Glucose; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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85. Manor E, Sion-Vardy N, Nash M, Bodner L: Angiomyoma of buccal vestibule: a rare case with a normal karyotype. J Laryngol Otol; 2007 Dec;121(12):1210-2
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  • Angiomyoma is an uncommon, benign, soft tissue tumour characterised by bundles of smooth muscle cells intermixed with numerous vascular channels, which usually develops in the lower extremities.
  • [MeSH-major] Angiomyoma / diagnosis. Mouth Neoplasms / diagnosis
  • [MeSH-minor] Adult. Cheek. Diagnosis, Differential. Humans. Male

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  • (PMID = 17524173.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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86. Mosquera JM, Fletcher CD: Expanding the spectrum of malignant progression in solitary fibrous tumors: a study of 8 cases with a discrete anaplastic component--is this dedifferentiated SFT? Am J Surg Pathol; 2009 Sep;33(9):1314-21
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  • Dedifferentiation is a well recognized, if sometimes controversial, form of tumor progression in certain types of soft tissue and bone sarcoma, and confers a worse prognosis when compared with the low-grade counterpart.
  • To date, dedifferentiation has not been described in solitary fibrous tumor (SFT).
  • Two cases were intrathoracic, 2 were located in the deep soft tissue of thigh, and single cases were located in the omentum, scalp, retroperitoneum, and abdominal wall.
  • In addition to typical features of benign-appearing SFT there was an abrupt transition to nondistinctive high-grade sarcoma in all cases.
  • One patient with an 11.5 cm intrathoracic tumor is alive with disease at 58 months after recurrence and metastasis.
  • Our results demonstrate that dedifferentiation in SFT, comparable with that in other low grade/intermediate soft-tissue tumors, poses a higher risk of tumor recurrence and/or metastasis, most notably in large and deep-seated tumors.
  • Similar to other dedifferentiated sarcomas, abrupt transition between low grade and high-grade areas is typically observed with loss of CD34 positivity.
  • The p53 and p16 overexpression in the high-grade component is common as in other dedifferentiated lesions, perhaps pertaining to the underlying molecular mechanism.
  • [MeSH-major] Cell Dedifferentiation. Disease Progression. Soft Tissue Neoplasms / pathology. Solitary Fibrous Tumors / secondary
  • [MeSH-minor] Adult. Aged. Anaplasia / genetics. Anaplasia / pathology. Antigens, CD34 / metabolism. Biomarkers, Tumor / metabolism. Chromosome Aberrations. Comparative Genomic Hybridization. DNA, Neoplasm / analysis. Female. Humans. Male. Middle Aged. Neoplasm Proteins / metabolism. Sarcoma / genetics. Sarcoma / metabolism. Sarcoma / secondary. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 19718788.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Neoplasm Proteins; 0 / P16 protein, human; 0 / Tumor Suppressor Protein p53
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87. Holzapfel BM, Geitner U, Diebold J, Glaser C, Jansson V, Dürr HR: Synovial hemangioma of the knee joint with cystic invasion of the femur: a case report and review of the literature. Arch Orthop Trauma Surg; 2009 Feb;129(2):143-8
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  • Synovial hemangioma is a rare benign intra-articular tumor.
  • Magnetic resonance imaging (MRI) showed the typical features of a soft tissue hemangioma and revealed a cystic invasion of the medial femur.
  • The tumor was locally excised and a partial synovectomy was performed.
  • Histological examination confirmed the diagnosis of a synovial hemangioma.
  • In a review of the recent literature we report the common features of a synovial hemangioma, with emphasis on its diagnosis and therapy.
  • [MeSH-major] Femur / surgery. Hemangioma / diagnosis. Joint Diseases / diagnosis. Knee Joint. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 18758797.001).
  • [ISSN] 1434-3916
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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88. Vasenwala SM, Iraqi AA, Ahmad S, Khan L, Zaheer S, Vasenwala RM: Malignant glomus tumour--a case report. Indian J Pathol Microbiol; 2006 Jan;49(1):40-1
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  • [Title] Malignant glomus tumour--a case report.
  • Glomus tumours are usually benign neoplasms of glomus bodies.
  • Here we report a rare case of malignant glomus tumour of soft tissue.
  • The tumour was 8 cm in size, infiltrating deep tissue, with nuclear atypia, high mitotic activity (6/HPF), atypical mitosis and showed recurrence, thus fulfilling all the criteria of malignancy.
  • [MeSH-major] Glomus Tumor / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16625975.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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89. Ui M, Ogawa K: Subdeltoid lipoma: a case with symptoms mimicking glenohumeral instability and subacromial impingement. Orthopedics; 2010 Jun;33(6):443
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  • Lipoma is the most frequently occurring benign soft tissue tumor in the shoulder and the axillary region in middle-aged and older persons, yet few such lipoma cases have been associated with clinical symptoms.
  • A 38-year-old right-handed man presented with an enlarged feeling and a painful back-and-forth popping in his left shoulder.
  • Magnetic resonance imaging showed a homogenous tumor in the subdeltoid that was isointense relative to the subcutaneous fat and fluid collection in the hypertrophic subacromial bursa.
  • As the tumor was considered from the clinical and imaging findings to be attributable to all clinical symptoms, it was resected en bloc with a satisfactory result.
  • Histopathologically, the tumor showed typical features of a simple lipoma.
  • To our knowledge, the present case is the first of a subdeltoid intermuscular lipoma of which mechanism developing symptoms was preoperatively surmised from imaging.
  • [MeSH-major] Lipoma / diagnosis. Muscle Neoplasms / diagnosis. Shoulder Dislocation / diagnosis. Shoulder Impingement Syndrome / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Shoulder

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  • [Copyright] Copyright 2010, SLACK Incorporated.
  • (PMID = 20806760.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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90. Zimering MB, Caldarella FA, White KE, Econs MJ: Persistent tumor-induced osteomalacia confirmed by elevated postoperative levels of serum fibroblast growth factor-23 and 5-year follow-up of bone density changes. Endocr Pract; 2005 Mar-Apr;11(2):108-14
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  • [Title] Persistent tumor-induced osteomalacia confirmed by elevated postoperative levels of serum fibroblast growth factor-23 and 5-year follow-up of bone density changes.
  • OBJECTIVE: To describe a case of persistent tumor-induced osteomalacia, determine whether serum fibroblast growth factor-23 (FGF-23) levels postoperatively indicate incomplete tumor resection, and report lumbar spine and forearm bone mineral density (BMD) changes during 5 years of follow-up.
  • METHODS: We present clinical, radiologic, histologic, and bone densitometry data as well as serum FGF-23 levels (determined with use of a novel C-terminal enzyme-linked immunosorbent assay) from the study patient and discuss these findings in the context of previous literature.
  • RESULTS: A 52-year-old man, who presented with muscle weakness and multiple fractures, was found to have low values for serum phosphorus, serum 1,25-dihydroxyvitamin D, and maximal tubular reabsorption of phosphate per glomerular filtration rate, a high level of serum alkaline phosphatase, and a normal serum concentration of parathyroid hormone, characteristic of tumor-induced osteomalacia.
  • Magnetic resonance imaging to evaluate an abnormality of the left foot revealed a soft tissue mass, biopsy of which confirmed the presence of a benign, phosphaturic, mesenchymal tumor.
  • The baseline serum FGF-23 level (2,050 RU/mL) was more than 17 times the upper limit of normal for adults (23 to 118 RU/mL) and decreased substantially within 1 day after partial resection of the tumor but remained above normal postoperatively.
  • CONCLUSION: The serum FGF-23 level is high in a substantial proportion of patients with tumor-induced osteomalacia.
  • The postoperative above normal levels of serum FGF-23 correlated with known persistence of tumor in our study patient.
  • This result suggests that this assay can provide clinicians with rapid prognostic information in patients with known or suspected residual tumor.
  • BMD should be assessed at both appendicular and axial sites in patients with persistent tumor-induced osteomalacia.
  • [MeSH-major] Bone Density. Fibroblast Growth Factors / blood. Foot. Mesenchymoma / complications. Osteomalacia / etiology. Soft Tissue Neoplasms / complications

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  • (PMID = 15901526.001).
  • [ISSN] 1530-891X
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / fibroblast growth factor 23; 62031-54-3 / Fibroblast Growth Factors
  • [Number-of-references] 18
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91. Weber KL, Peabody T, Frassica FJ, Mott MP, Parsons TW 3rd: Tumors for the general orthopedist: how to save your patients and practice. Instr Course Lect; 2010;59:579-91
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  • It is likely that most orthopaedic surgeons will see a patient with a benign or malignant musculoskeletal tumor sometime during their career.
  • However, because of the rarity of these entities, many surgeons may benefit from a review of how to evaluate a patient with a bone lesion or soft-tissue mass.
  • A logical approach is necessary in evaluating imaging studies as well as in the workup of children and adults with a possible tumor.
  • If the treatment algorithms lead to a conclusive diagnosis of a benign bone tumor, benign soft-tissue mass, or metastatic bone disease, the orthopaedic surgeon may choose to definitively treat the patient.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Cysts / diagnosis. Joint Diseases / pathology. Orthopedics. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 20415407.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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92. Weiser JA, Nord KM, Grossman ME: Glomus tumor masquerading for 22 years as osteoarthritis of the hip. Cutis; 2008 Apr;81(4):339-42
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  • [Title] Glomus tumor masquerading for 22 years as osteoarthritis of the hip.
  • Glomus tumors are rare benign mesenchymal neoplasms that account for less than 2% of soft tissue tumors.
  • These neoplasms typically are small nodules less than 1 cm in diameter, associated with pain that is exacerbated by tactile stimulation and cold hypersensitivity.
  • We present a case of a large glomus tumor of the left lateral hip associated with a long history of severe pain of the left hip interfering with ambulation.
  • Chronic pain as a result of a subcutaneous glomus tumor is rare and frequently misdiagnosed.
  • In the case reported, a solid glomus tumor presented with 22 years of unilateral hip pain attributed to posttraumatic degenerative joint disease.
  • Excision of a 4 x 3-cm nodule resulted in complete resolution of tenderness and joint pain.
  • Subcutaneous glomus tumors can have unusually large size and location and should be considered in the differential diagnosis of chronic, atypical, or treatment-resistant joint pain.
  • [MeSH-major] Glomus Tumor / diagnosis. Hip. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Chronic Disease. Diagnosis, Differential. Humans. Male. Middle Aged. Osteoarthritis, Hip / diagnosis. Pain / etiology

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  • (PMID = 18491482.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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93. Lee S, Le H, Munk P, Malfair D, Lee ChH, Clarkson P: Glomus tumour in the forearm: a case report and review of MRI findings. JBR-BTR; 2010 Nov-Dec;93(6):292-5
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  • [Title] Glomus tumour in the forearm: a case report and review of MRI findings.
  • Glomus tumours are uncommon benign neoplasms characterised by the proliferation of modified smooth muscle cells known as glomus cells.
  • We present a case of a solitary painful forearm lesion in an 81-year-old man, and review the English literature on extra-digital glomus tumours documenting MR imaging features.
  • [MeSH-major] Forearm. Glomus Tumor / diagnosis. Magnetic Resonance Imaging. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Biopsy. Diagnosis, Differential. Humans. Male

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  • (PMID = 21381525.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Belgium
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94. Campanacci DA, Scoccianti G, Beltrami G, Mugnaini M, Capanna R: Ankle arthrodesis with bone graft after distal tibia resection for bone tumors. Foot Ankle Int; 2008 Oct;29(10):1031-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Treatment of distal tibial tumors is challenging due to the scarce soft tissue coverage of this area.
  • Ankle arthrodesis has proven to be an effective treatment in primary and post-traumatic joint arthritis, but few papers have addressed the feasibility and techniques of ankle arthrodesis in tumor surgery after long bone resections.
  • MATERIALS AND METHODS: Resection of the distal tibia and reconstruction by ankle fusion using non-vascularized structural bone grafts was performed in 8 patients affected by malignant (5 patients) or aggressive benign (3 patients) tumors.
  • CONCLUSION: Resection of the distal tibia and arthrodesis of the ankle with non-vascularized structural bone grafts, combined with autologous bone chips, can be an effective procedure in bone tumor surgery with durable and satisfactory functional results.
  • [MeSH-major] Ankle Joint / surgery. Arthrodesis. Bone Neoplasms / surgery. Tibia / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Nails. Bone Plates. Female. Fibula / transplantation. Follow-Up Studies. Giant Cell Tumor of Bone / surgery. Hemangioendothelioma / surgery. Histiocytoma, Benign Fibrous / surgery. Humans. Ilium / transplantation. Limb Salvage. Male. Middle Aged. Pain Measurement. Postoperative Complications. Retrospective Studies. Sarcoma / surgery. Transplantation, Autologous. Transplantation, Homologous. Treatment Outcome

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  • (PMID = 18851821.001).
  • [ISSN] 1071-1007
  • [Journal-full-title] Foot & ankle international
  • [ISO-abbreviation] Foot Ankle Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Bara T, Bancu S, Bara T Jr, Mureşan M, Bancu L, Azamfirei L, Podeanu D, Mureşan S: [Gastric stromal tumor with liver and subcutaneus metastasis. Case report]. Chirurgia (Bucur); 2009 Sep-Oct;104(5):621-4
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  • [Title] [Gastric stromal tumor with liver and subcutaneus metastasis. Case report].
  • [Transliterated title] Tumoră stromală gastrică cu metastaze hepatice şi subcutanate. Prezentare de caz.
  • Very importants factors for grading are the tumour localisation, the invasion of serosa or mucosa, the dimensions of tumour and the number of mytosis.
  • We present a case with haemoragic gastric stromal tumour, with small dimensions, which was initially diagnosed as a "benign" tumour.
  • CONCLUSIONS: The gastrointestinals stromal tumours represent a very rare group of digestive tract tumors, with malignant potentially evolution; the first choice of treatment is surgery, with complete ablation of the tumour.
  • [MeSH-major] Gastrointestinal Stromal Tumors / secondary. Liver Neoplasms / secondary. Soft Tissue Neoplasms / secondary. Stomach Neoplasms / pathology

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  • (PMID = 19943565.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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96. Moon SE, Cho YJ, Kwon OS: Subungual schwannoma: a rare location. Dermatol Surg; 2005 May;31(5):592-4
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  • BACKGROUND: Schwannoma is a benign tumor of neural tissue and usually develops in deeper soft tissue.
  • Cutaneous involvement is uncommon, and a subungual location is extremely rare.
  • METHOD: A 49-year-old man had a subungual tumor on his right thumb of 8 years duration.
  • The tumor was excised using a transungual approach.
  • CONCLUSION: We describe a case of schwannoma that developed in the subungual area of a thumb.
  • Although schwannoma rarely develops in this area, it should be considered in the differential diagnosis of subungual tumor.
  • [MeSH-major] Bone Neoplasms / diagnosis. Nails, Malformed / etiology. Neurilemmoma / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 15962750.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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97. Mack LA, Crowe PJ, Yang JL, Schachar NS, Morris DG, Kurien EC, Temple CL, Lindsay RL, Magi E, DeHaas WG, Temple WJ: Preoperative chemoradiotherapy (modified Eilber protocol) provides maximum local control and minimal morbidity in patients with soft tissue sarcoma. Ann Surg Oncol; 2005 Aug;12(8):646-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preoperative chemoradiotherapy (modified Eilber protocol) provides maximum local control and minimal morbidity in patients with soft tissue sarcoma.
  • BACKGROUND: Local recurrence rates of 15% to 30% after treatment of soft tissue sarcoma (STS) are still common but unacceptable.
  • Risk factors for death included tumor stage (hazard ratio, 1.54; P = .001) and tumor grade (hazard ratio, 1.4; P = .02).
  • Three patients (4%) required reoperation for tissue loss, and eight patients (10.6%) developed minor wound complications.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antibiotics, Antineoplastic / administration & dosage. Chemotherapy, Adjuvant. Doxorubicin / administration & dosage. Female. Histiocytoma, Benign Fibrous / pathology. Histiocytoma, Benign Fibrous / surgery. Histiocytoma, Benign Fibrous / therapy. Humans. Leiomyosarcoma / pathology. Leiomyosarcoma / surgery. Leiomyosarcoma / therapy. Liposarcoma / pathology. Liposarcoma / surgery. Liposarcoma / therapy. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies


98. Perić A, Baletić N, Cerović S, Vukomanović-Durdević B: Middle turbinate angiofibroma in an elderly woman. Vojnosanit Pregl; 2009 Jul;66(7):583-6
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  • BACKGROUND: Angiofibromas are histologically benign vascular tumors, originating from the nasopharynx, near by the area of sphenopalatine foramen.
  • These neoplasms occur typically in male adolescents.
  • We present the first case of an elderly woman with tumor arising from the middle turbinate, diagnosed as angiofibroma.
  • Computed tomography (CT) scan showed a soft-tissue opacity that filled the anterior part of the left nasal cavity.
  • After the endoscopic excision of the mass, postoperative pathohistological and immunohistochemical analysis confirmed the diagnosis of an angiofibroma.
  • [MeSH-major] Angiofibroma / diagnosis. Nose Neoplasms / diagnosis. Turbinates

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  • (PMID = 19678585.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Serbia
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99. Mentzel T, Dei Tos AP, Sapi Z, Kutzner H: Myopericytoma of skin and soft tissues: clinicopathologic and immunohistochemical study of 54 cases. Am J Surg Pathol; 2006 Jan;30(1):104-13
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  • [Title] Myopericytoma of skin and soft tissues: clinicopathologic and immunohistochemical study of 54 cases.
  • Perivascular neoplasms comprise traditionally glomus tumor and hemangiopericytoma (HPC).
  • Whereas glomus tumor represents a well-defined entity, the existence of HPC as a separate entity has been questioned because a number of neoplasms of different lines of differentiation are characterized by a HPC-like vascular growth pattern.
  • A large series of myopericytoma of skin and soft tissues has been analyzed to further characterize the clinicopathologic spectrum of this entity.
  • Fifty-four cases of myopericytoma of skin and soft tissues were retrieved and the histology reviewed.
  • In 20 cases, the neoplasms were confined to the dermis, in 6 cases an extension into the subcutis was seen, and 24 as well as 4 cases arose in subcutaneous and deep soft tissue, respectively.
  • Histologically, in all cases, numerous thin-walled vessels and a concentric, perivascular arrangement of ovoid, plump spindled to round myoid tumor cells was seen.
  • However, a broad morphologic spectrum ranging from hypocellular, fibroma-like (3 cases), myofibroma-like (2 cases), angioleiomyoma-like (12 cases), and HPC-like neoplasms (13 cases) to classic myopericytomas (14 cases) and immature, cellular lesions (2 cases) was noted.
  • In addition, 2 neoplasms with focal glomoid features, 5 intravascular, and 1 malignant myopericytomas were found.
  • Despite marginal or incomplete excision in 23 of 46 cases, only 2 neoplasms (1 malignant and 1 intravascular myopericytoma) recurred locally (within 1 and 4 years, respectively).
  • Despite overlapping morphologic features to angioleiomyoma and myofibroma, myopericytoma represents a distinct perivascular, myoid neoplasm of skin and soft tissues, characterized by a broad morphologic spectrum of concentrically, perivascularly growing myoid tumor cells that stain positively for ASMA and often for h-caldesmon, whereas desmin is usually negative.
  • Most cases of myopericytoma behave in a benign fashion, but local recurrences and rarely metastases may occur in atypical and malignant neoplasms.
  • [MeSH-major] Biomarkers, Tumor / analysis. Neoplasms, Vascular Tissue / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Angiomyoma / pathology. Diagnosis, Differential. Female. Glomus Tumor / pathology. Hemangiopericytoma / metabolism. Hemangiopericytoma / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Myofibroma / pathology

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  • (PMID = 16330949.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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100. Folpe AL, Mentzel T, Lehr HA, Fisher C, Balzer BL, Weiss SW: Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature. Am J Surg Pathol; 2005 Dec;29(12):1558-75
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  • [Title] Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature.
  • This family of tumors includes angiomyolipoma (AML), clear cell sugar tumor of the lung (CCST), lymphangioleiomyomatosis (LAM), and very rare tumors in other locations.
  • Because non-AML/non-LAM PEComas are extremely rare and their natural history and prognostic features undefined, we present our experience with 26 PEComas of soft tissue and the gynecologic tract, the largest series to date.
  • Sites of involvement included the omentum or mesentery (6 cases), uterus (4 cases), pelvic soft tissues (3 cases), abdominal wall (2 cases), uterine cervix (2 cases), and vagina, retroperitoneum, thigh, falciform ligament, scalp, broad ligament, forearm, shoulder, and neck (1 case each).
  • Recurrence and/or metastasis was strongly associated tumor size > median size (8 cm), mitotic activity greater than 1/50 HPF, and necrosis.
  • We conclude that PEComas of soft tissue and gynecologic origin may be classified as "benign," "of uncertain malignant potential," or "malignant."
  • Small PEComas without any worrisome histologic features are most likely benign.
  • PEComas with nuclear pleomorphism alone ("symplastic") and large PEComas without other worrisome features have uncertain malignant potential.
  • [MeSH-major] Biomarkers, Tumor / analysis. Epithelioid Cells / pathology. Genital Neoplasms, Female / pathology. Neoplasms, Connective and Soft Tissue / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Follow-Up Studies. Humans. Immunohistochemistry. Immunophenotyping. Male. Middle Aged. Mitosis. Neoplasm Metastasis. Neoplasm Recurrence, Local. Retrospective Studies. Survival Analysis. Time Factors. Treatment Outcome. Tumor Burden

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  • (PMID = 16327428.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 56
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