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1. Delaney D, Diss TC, Presneau N, Hing S, Berisha F, Idowu BD, O'Donnell P, Skinner JA, Tirabosco R, Flanagan AM: GNAS1 mutations occur more commonly than previously thought in intramuscular myxoma. Mod Pathol; 2009 May;22(5):718-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Mutation detection plays an important role in diagnostic pathology, not only in providing a tissue diagnosis, but also in predicting response to antitumourigenic agents.
  • However, mutation detection strategies are often hampered by masking of mutant alleles by wild-type sequences.
  • Coamplification at lower denaturation temperature PCR (COLD-PCR) reportedly increases the proportion of rare variant sequences in a wild-type background by using PCR cycles in which the denaturation temperature is reduced to favour product formation with lower melt temperatures and heteroduplexes arising from minor variants.
  • Intramuscular myxoma is a rare benign soft tissue neoplasm that occurs sporadically and less commonly in association with fibrous dysplasia (Mazabraud's syndrome).
  • Mutations were detected in two cases where a diagnosis of low-grade myxofibrosarcoma had been favoured over intramuscular myxoma.
  • This study shows the power of COLD-PCR compared with conventional PCR in mutation detection, and shows that GNAS1 mutation detection increases diagnostic accuracy when distinguishing between intramuscular myxoma and low-grade myxofibrosarcoma.
  • [MeSH-major] GTP-Binding Protein alpha Subunits, Gs / genetics. Myxoma / genetics. Polymerase Chain Reaction / methods. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Cold Temperature. DNA Mutational Analysis. Diagnosis, Differential. Fibrosarcoma / genetics. Fibrosarcoma / pathology. Humans. Mutation. Sensitivity and Specificity

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  • (PMID = 19287459.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.6.1.- / GNAS protein, human; EC / GTP-Binding Protein alpha Subunits, Gs
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2. Holzheimer RG: Adverse events of sutures: possible interactions of biomaterials? Eur J Med Res; 2005 Dec 7;10(12):521-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tissue reactions which might be associated with suture material have rarely been reported in the past.
  • After a long period without complications caused by suture material we observed 12 cases of unexpected tissue reactions after clean operations.
  • Our patients 3-8 weeks after uneventful elective clean operations (varicose vein, hernia, benign soft tissue tumor) had unexpected tissue reactions (inflammation, granuloma, extrusion, fistula, abscess) in the vicinity of Vicryl, suture material (8 cases with Vicryl, 4 cases with Vicryl plus.
  • After removal of the suture material and the granulomatous tissue wounds healed without any further disturbance.
  • These tissue reactions have been observed in patients with subcuticular sutures as well as in patients with deeper located vein ligatures.
  • We use Vicryl, suture material for ambulatory surgery since 1999 and did not see complications for a long period up to now.
  • For clarification evaluation of the tissue reactions of these biomaterials including possible interactions or combined reactions should be done.
  • [MeSH-major] Cyanoacrylates / adverse effects. Polyglactin 910 / adverse effects. Postoperative Complications / etiology. Sutures. Tissue Adhesives / adverse effects
  • [MeSH-minor] Adult. Aged. Ambulatory Surgical Procedures. Biocompatible Materials / adverse effects. Child. Drug Interactions. Female. Humans. Male. Middle Aged. Wound Healing / drug effects

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  • (PMID = 16356867.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Cyanoacrylates; 0 / Tissue Adhesives; 34346-01-5 / Polyglactin 910; 6701-17-3 / octyl 2-cyanoacrylate
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