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1. Karonidis A, Rigby HS, Orlando A: Collagenosis Nuchae: a case report of a rare and often misdiagnosed condition. J Plast Reconstr Aesthet Surg; 2007;60(3):320-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Collagenosis Nuchae: a case report of a rare and often misdiagnosed condition.
  • CN is a rare benign soft tissue tumour that arises from the posterior cervical subcutaneous tissue with predilection for the interscapular and paraspinal regions.
  • The true incidence of CN is probably higher than recognised and CN should be in the differential diagnosis of head and neck lesions.
  • Histological examination is required for the diagnosis.
  • Careful total excision provides cure and accurate diagnosis.
  • [MeSH-major] Fibroma / diagnosis. Head and Neck Neoplasms / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 17293293.001).
  • [ISSN] 1748-6815
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 10
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2. Poprach A, Michalová E, Pavlík T, Lakomy R, Vyskocil J, Nemeccek R, Zaloudík J, Vyzula R, Kocák I, Kocáková I: [Actual state of ex vivo chemoresistance testing of malignant tumors in Masaryk Memorial Cancer Institute Brno]. Klin Onkol; 2008;21(3):116-21
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  • (1) metastatic malignant melanoma, (2) soft tissue sarcoma (STS), either primary or recurrent/metastic, (3) primary or metastatic renal cancer, (4) recurrent ovarian cancer and (5) other diagnosis "on clinician's request".
  • Sensitivity to certain chemotherapy agent observed ex vivo does not necessarily mean that the cancer would also be sensitive to the same agent in vivo, however, ex vivo resistance with following in vivo sensitivity of the tumour has not been observed to date.
  • The cultivation of malignant cells is very uncertain in solid tumours, which consist of several malignant cell multiclones (benign/stromal cells may outgrow malignant cells).
  • [MeSH-minor] Drug Resistance, Neoplasm. Female. Humans. Kidney Neoplasms / drug therapy. Melanoma / drug therapy. Ovarian Neoplasms / drug therapy. Sarcoma / drug therapy

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  • (PMID = 19097421.001).
  • [ISSN] 0862-495X
  • [Journal-full-title] Klinická onkologie : casopis Ceské a Slovenské onkologické spolecnosti
  • [ISO-abbreviation] Klin Onkol
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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3. Balke M, Streitbuerger A, Budny T, Henrichs M, Gosheger G, Hardes J: Treatment and outcome of giant cell tumors of the pelvis. Acta Orthop; 2009 Oct;80(5):590-6
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  • METHODS: 20 patients with histologically benign GCT of the pelvis were included in this study.
  • RESULTS: 1 patient with a pubic tumor developed a local recurrence 1 year after intralesional resection and additional curettage of the margins.
  • The recurrence presented as a small soft tissue mass within the scar tissue of the gluteal muscles and was treated by resection.
  • [MeSH-major] Bone Neoplasms / surgery. Giant Cell Tumor of Bone / surgery. Pelvic Bones
  • [MeSH-minor] Adult. Aged. Bone Cements. Bone Transplantation. Curettage. Embolization, Therapeutic / methods. Female. Follow-Up Studies. Humans. Ilium / pathology. Ilium / surgery. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Radiotherapy, Adjuvant. Retrospective Studies. Treatment Outcome

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  • (PMID = 19916695.001).
  • [ISSN] 1745-3682
  • [Journal-full-title] Acta orthopaedica
  • [ISO-abbreviation] Acta Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bone Cements
  • [Other-IDs] NLM/ PMC2823344
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4. Miettinen M, Makhlouf HR, Sobin LH, Lasota J: Plexiform fibromyxoma: a distinctive benign gastric antral neoplasm not to be confused with a myxoid GIST. Am J Surg Pathol; 2009 Nov;33(11):1624-32
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  • [Title] Plexiform fibromyxoma: a distinctive benign gastric antral neoplasm not to be confused with a myxoid GIST.
  • A great majority of gastric mesenchymal tumors are gastrointestinal stromal tumor (GIST).
  • A rare group of non-GISTs include myxoid mesenchymal neoplasms.
  • In this report, we describe 12 cases of a distinctive gastric tumor, named here as plexiform fibromyxoma.
  • All tumors were located in the gastric antrum and 6 of them also extended into extragastric soft tissues or into the duodenal bulb.
  • The tumor cells varied from oval to spindled and had limited atypia and mitotic activity < 5/50 high-power fields.
  • Immunohistochemically, the tumor cells were positive for alpha smooth muscle actin, and variably for CD10, and were consistently negative for KIT, DOG1, CD34, desmin, and S100 protein.
  • Additional 3 patients survived 14 to 25 years with unknown tumor status.
  • Plexiform fibromyxoma is a distinctive benign gastric antral neoplasm that should be separated from GIST, nerve sheath tumors, and other fibromyxoid neoplasms.
  • [MeSH-major] Fibroma / diagnosis. Gastrointestinal Stromal Tumors / diagnosis. Pyloric Antrum / pathology. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Child. Diagnosis, Differential. Disease-Free Survival. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Invasiveness. Young Adult

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  • (PMID = 19675452.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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5. Jeon DG, Lee SY, Kim JW: Bone primary sarcomas undergone unplanned intralesional procedures - the possibility of limb salvage and their oncologic results. J Surg Oncol; 2006 Dec 1;94(7):592-8
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  • BACKGROUND: It is quite rare but some primary sarcomas of the bone can be misdiagnosed as benign and be treated using intralesional procedures.
  • An unplanned surgical excision occurs when tumors are removed without the appropriate preoperative evaluation and consideration for the need to obtain tumor-free margins.
  • Residual tumor tissue as a result of unplanned excision of soft tissue sarcoma is a risk factor for local recurrence.
  • Limb salvage procedures are worthwhile in cases whose initial radiographic findings simulate benign lesions, showing favorable response to neoadjuvant chemotherapy.
  • The relative contraindication to the limb salvage is cases with a history of a pathologic fracture and extensive operative fixation.
  • [MeSH-major] Bone Neoplasms / surgery. Limb Salvage. Osteosarcoma / surgery. Sarcoma / surgery
  • [MeSH-minor] Adolescent. Adult. Chemotherapy, Adjuvant. Curettage. Female. Humans. Lower Extremity / surgery. Male. Middle Aged. Neoplasm Recurrence, Local. Soft Tissue Neoplasms / mortality. Soft Tissue Neoplasms / surgery. Survival Rate. Treatment Outcome


6. Bergman S, Brownlee NA, Geisinger KR, Ward WG, Pettenati MJ, Koty P, Ellis E, Beaty MW, Kilpatrick SE: Diagnostic pitfalls associated with fine-needle aspiration biopsy in a patient with the myxoid variant of monophasic fibrous synovial sarcoma. Diagn Cytopathol; 2006 Nov;34(11):761-7
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  • Synovial sarcoma (SS) is one of the most common soft tissue tumors that typically presents in the extremities of young adults, but may occur at any site and affect children during the first decade.
  • A fine-needle aspiration biopsy of an 8 cm subcutaneous mass was performed revealing a myxoid spindle cell neoplasm.
  • The cytologic differential diagnosis included a myxoid neurofibroma, neurothekeoma, and a myxoid sarcoma.
  • Examination of the tissue by fluorescence in situ hybridization confirmed the presence of characteristic SS SYT gene rearrangement at chromosome 18q11.2.
  • We report the cytologic features of a myxoid monophasic fibrous SS, and discuss its distinction from other benign and malignant myxoid soft tissue neoplasms.
  • [MeSH-major] Ganglion Cysts / pathology. Sarcoma, Synovial / diagnosis. Sarcoma, Synovial / pathology

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  • [Copyright] (C) 2006 Wiley-Liss, Inc.
  • (PMID = 17121200.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Kresse SH, Skårn M, Ohnstad HO, Namløs HM, Bjerkehagen B, Myklebost O, Meza-Zepeda LA: DNA copy number changes in high-grade malignant peripheral nerve sheath tumors by array CGH. Mol Cancer; 2008;7:48
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  • BACKGROUND: Malignant peripheral nerve sheath tumors (MPNSTs) are rare and highly aggressive soft tissue tumors showing complex chromosomal aberrations.
  • Within 17q, the genes topoisomerase II-alpha (TOP2A), ets variant gene 4 (E1A enhancer binding protein, E1AF) (ETV4) and baculoviral IAP repeat-containing 5 (survivin) (BIRC5) showed increased expression in all samples compared to two benign tumors.
  • Increased expression of these genes has previously been associated with poor survival in other malignancies, and for TOP2A, in MPNSTs as well.
  • In addition, we have analyzed the expression of five micro RNAs located within the 17q23.2-q25.3 region, but none of them showed high expression levels compared to the benign tumors.
  • [MeSH-major] DNA, Neoplasm / analysis. Gene Dosage. Gene Expression Profiling / methods. Gene Expression Regulation, Neoplastic. Nerve Sheath Neoplasms / genetics. Oligonucleotide Array Sequence Analysis. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Adenovirus E1A Proteins / genetics. Adult. Aged. Amino Acid Oxidoreductases / genetics. Antigens, Neoplasm / genetics. Chromosomes, Human, Pair 17. Chromosomes, Human, Pair 8. DNA Topoisomerases, Type II / genetics. DNA-Binding Proteins / genetics. Female. Gene Expression Regulation, Enzymologic. Humans. Inhibitor of Apoptosis Proteins. Male. Microtubule-Associated Proteins / genetics. Middle Aged. Neoplasm Proteins / genetics. Prognosis. Proto-Oncogene Proteins / genetics. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 18522746.001).
  • [ISSN] 1476-4598
  • [Journal-full-title] Molecular cancer
  • [ISO-abbreviation] Mol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adenovirus E1A Proteins; 0 / Antigens, Neoplasm; 0 / BIRC5 protein, human; 0 / DNA, Neoplasm; 0 / DNA-Binding Proteins; 0 / ETV4 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; 0 / Proto-Oncogene Proteins; EC 1.4.- / Amino Acid Oxidoreductases; EC 1.4.3.- / LOXL2 protein, human; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
  • [Other-IDs] NLM/ PMC2442610
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8. Awasthi R, O'Neill JK, Keen CE, Sarsfield PT, Devaraj VS, Stone CA, Smith ME: Biphasic solitary fibrous tumour: a report of two cases with epithelioid features. Virchows Arch; 2006 Mar;448(3):306-10
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  • [Title] Biphasic solitary fibrous tumour: a report of two cases with epithelioid features.
  • We present two cases of solitary fibrous tumour (SFT) showing biphasic morphology with a spectrum of malignant epithelioid components.
  • Slides prepared from formalin-fixed and paraffin-embedded tissue from both cases were stained with haematoxylin and eosin and by immunohistochemistry.
  • Interphase fluorescent in situ hybridisation studies were performed in both cases using paraffin-embedded tissue to look for the t(X;18) translocation, thereby to exclude synovial sarcoma.
  • Both cases showed biphasic morphology with some areas having typical benign spindled SFT morphology (including CD34 expression) and other areas having a malignant epithelioid appearance.
  • In the second case, the immunophenotype of the epithelioid component was similar to that of the benign SFT component.
  • These findings suggest that epithelioid change in SFT shows a range of differentiation at one end, similar to that of a standard SFT, and at the other end, possibly acquiring epithelial characteristics.
  • [MeSH-major] Epithelioid Cells / pathology. Soft Tissue Neoplasms / pathology. Solitary Fibrous Tumors / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Cell Transformation, Neoplastic. DNA, Neoplasm / analysis. Diagnosis, Differential. Female. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Sarcoma, Synovial / diagnosis

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  • (PMID = 16244869.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm
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9. Plathow C, Weber MA, Debus J, Kauczor HU: [Imaging of sacral chordoma: comparison between MRI and CT]. Radiologe; 2005 Jan;45(1):63-8
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  • [Transliterated title] Bildgebende Diagnostik bei Chordomen des Beckens: Vergleich der Modalitäten CT und MRT.
  • AIM: Sacral chordoma is a primarily benign tumor with a high tendency to recur.
  • A correct definition of tumor volume is a significant prognostic factor.
  • Following parameters were analyzed by two independent radiologists: septation, signs of blood and ossification in the tumor tissue, contrast enhancement, maximal tumor diameter, infiltration of the soft tissue, the dural salc and the cauda equina and multifocality.
  • RESULTS: In CT all chordomas showed a hypodensity to the normal tissue and in MRI a hyperintensity on T2w images with a low level of contrast enhancement.
  • On the basis of the more precise soft tissue contrast of MRI compared with CT, MRI was significantly more accurate in all tested parameters (p <0.05) besides in detecting tumor ossification.
  • In CT tumor volume was frequently underestimated.
  • [MeSH-major] Chordoma / diagnosis. Magnetic Resonance Imaging. Sacrum / pathology. Spinal Neoplasms / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Contrast Media / administration & dosage. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / pathology. Ossification, Heterotopic / diagnosis. Ossification, Heterotopic / pathology. Sensitivity and Specificity. Tumor Burden

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  • (PMID = 15662521.001).
  • [ISSN] 1432-2102
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
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10. Rehders A, Stoecklein NH, Poremba C, Alexander A, Knoefel WT, Peiper M: Reexcision of soft tissue sarcoma: sufficient local control but increased rate of metastasis. World J Surg; 2009 Dec;33(12):2599-605
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  • [Title] Reexcision of soft tissue sarcoma: sufficient local control but increased rate of metastasis.
  • BACKGROUND: Assuming a benign tumor, soft tissue sarcomas are often treated by inadequate resection.
  • Therefore, it was our goal to evaluate the results of this treatment with particular respect to residual tumor.
  • The assessed endpoints were local recurrence-free survival, distant metastasis-free survival, and tumor-related mortality.
  • Residual tumor was detected in 43 patients (31%) and was significantly associated with reduced relapse-free and overall survival.
  • CONCLUSIONS: Despite an incomplete initial resection, reexcision enables local control similar to that in patients without residual tumor.
  • Still, these patients have a worse prognosis owing to an increased rate of distant metastasis; therefore, patients with soft tissue masses of unknown identity should be transferred to centers that specialize in treating sarcomas for adequate initial resection.
  • [MeSH-major] Neoplasm Recurrence, Local / surgery. Neoplasm, Residual / surgery. Sarcoma / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Reoperation. Survival Analysis. Young Adult

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  • [ErratumIn] World J Surg. 2010 Aug;34(8):1991
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  • (PMID = 19838751.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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11. Sato K, Ueda Y, Miwa S, Yokogawa A, Ozaki M, Katsuda S: Low-grade malignant soft-tissue perineurioma: interphase fluorescence in situ hybridization. Pathol Int; 2008 Nov;58(11):718-22
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  • [Title] Low-grade malignant soft-tissue perineurioma: interphase fluorescence in situ hybridization.
  • Perineuriomas are usually benign soft-tissue tumors that arise from perineurial cells of the peripheral nerve sheath.
  • Low-grade malignant perineurioma is a rare type of perineurioma, presenting with infiltrative growth, low mitotic activity, and a lack of necrosis.
  • This report describes a case of low-grade malignant perineurioma in a 60-year-old man who presented with a growing tumor on the dorsal side of his left wrist.
  • The tumor was surgically excised and showed no adhesion to the surrounding muscle and no continuity with nerves.
  • Histology indicated that the tumor contained hypercellular and hypocellular areas with spindle-shaped cells proliferating in storiform patterns or perivascular whorling.
  • There was moderate infiltrative growth into the surrounding tissue.
  • On immunohistochemistry tumor cells were found to be positive for epithelial membrane antigen, glucose transporter protein 1, and claudin-1.
  • Approximately 18.4% of tumor nuclei were labelled for Ki-67.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Cell Nucleus / chemistry. Cell Nucleus / pathology. Chromosome Aberrations. Chromosomes, Human, Pair 13. Claudin-1. DNA, Neoplasm / analysis. Glucose Transporter Type 1 / analysis. Humans. In Situ Hybridization, Fluorescence. Ki-67 Antigen / analysis. Male. Membrane Proteins / analysis. Middle Aged. Mitosis. Mucin-1 / analysis. Treatment Outcome. Wrist / surgery

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  • (PMID = 18844938.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CLDN1 protein, human; 0 / Claudin-1; 0 / DNA, Neoplasm; 0 / Glucose Transporter Type 1; 0 / Ki-67 Antigen; 0 / Membrane Proteins; 0 / Mucin-1
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12. Sarikcioglu L, Demirel BM, Ozsoy U, Gurer EI, Oguz N, Ucar Y: Angiolipoma located inside the obturator canal and supplied by the umbilical artery. Ann Anat; 2007;189(1):75-8
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  • During dissection of the retropubic region of a 55-year-old female cadaver, we encountered an angiolipoma located inside the obturator canal which was connected to the wall of the urinary bladder by a fibrous cord.
  • Microscopically the benign soft tissue tumor was characterized by lobules of mature adipocytes and densely distributed networks of small and larger blood vessels, thus resembling typical histological features of an angiolipoma.

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  • (PMID = 17319612.001).
  • [ISSN] 0940-9602
  • [Journal-full-title] Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft
  • [ISO-abbreviation] Ann. Anat.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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13. Al-Otaibi M, Lach B, Al Shail E: December 2004: one-year-old girl with aggressive skull tumor. Brain Pathol; 2005 Apr;15(2):171-3
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  • [Title] December 2004: one-year-old girl with aggressive skull tumor.
  • December 2004. Twelve-month old girl presented with recurrent subcutaneous lesion in the left parietal region, one year after excision of a "benign" tumor.
  • An MRI demonstrated left temporo-parietal skull tumor infiltrating the soft tissue, surrounding craniotomy flap, and extending to the brain parenchyma.
  • Biopsy revealed biphasic neoplasm displaying nests of poorly differentiated neuroblastic cells positive for synaptophysin and pigmented cuboidal epithelioid cell positive for keratins, epithelial membrane antigen and MHB-45.
  • Interestingly, cell with the neuroblastic immunophenotype displayed 80% nuclear MIB-1 reactivity indicating that the aggressiveness of the neoplasm was confined mostly to this pattern of differentiation.
  • The overall histological features are consistent with a rare malignant variant of a melanotic neuroectodermal tumor of infancy.
  • [MeSH-major] Neoplasm Recurrence, Local / pathology. Neuroectodermal Tumor, Melanotic / pathology. Parietal Bone / pathology. Skull Neoplasms / pathology
  • [MeSH-minor] Brain Neoplasms / secondary. Diagnosis, Differential. Fatal Outcome. Female. Humans. Immunohistochemistry. Infant. Magnetic Resonance Imaging. Soft Tissue Neoplasms / secondary. Tomography, X-Ray Computed

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  • (PMID = 15912891.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
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14. Nalbantoglu U, Gereli A, Kocaoglu B, Aktas S: Fibro-osseous pseudotumor of the digits: a rare tumor in an unusual location. J Hand Surg Am; 2008 Feb;33(2):273-6
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  • [Title] Fibro-osseous pseudotumor of the digits: a rare tumor in an unusual location.
  • Fibro-osseous pseudotumor of the digits (FOPT) is a rare benign lesion of the hand.
  • When FOPT originates in an unusual anatomic region (other than the digits), it can imitate a malignant neoplasm, and consequently surgical treatment can be improper.
  • [MeSH-major] Fibroma / pathology. Osteoma / pathology. Soft Tissue Neoplasms / pathology. Wrist / pathology

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  • (PMID = 18294555.001).
  • [ISSN] 0363-5023
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Al-Khateeb TH: Benign oral masses in a Northern Jordanian population-a retrospective study. Open Dent J; 2009;3:147-53
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  • [Title] Benign oral masses in a Northern Jordanian population-a retrospective study.
  • The aim of this study was to evaluate the relative frequencies, types and distribution of benign oral masses in North Jordanians.
  • The records of the Department of Pathology at Jordan University of Science & Technology were reviewed and analyzed for patients with benign oral soft tissue masses, received during an 11-year period (1991-2001).
  • A sum of 818 benign oral soft tissue masses (4% neoplastic and 96% non-neoplastic) was analyzed.
  • Common benign neoplasms were salivary pleomorphic adenoma and lipoma.
  • The sites commonly affected by benign neoplasms were the palate, tongue, upper lip and buccal mucosa, in a descending order and the sites commonly affected by non-neoplastic lesions were the gingiva, buccal mucosa, lower lip and tongue in a descending order.
  • It is concluded that some of the features of benign oral masses in north Jordanians published in this paper are similar to those from other countries, and some are different.
  • Further nationwide population-based surveys are needed to further define the epidemiology of benign oral masses among Jordanians.

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  • [Cites] Oral Dis. 2008 May;14(4):356-66 [18410578.001]
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  • (PMID = 19672335.001).
  • [ISSN] 1874-2106
  • [Journal-full-title] The open dentistry journal
  • [ISO-abbreviation] Open Dent J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2724667
  • [Keywords] NOTNLM ; Benign lesions of the upper aerodigestive tract / Jordanians. / Oral cavity tumor / Soft tissue neoplasm
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16. Nilsson M, Panagopoulos I, Mertens F, Mandahl N: Fusion of the HMGA2 and NFIB genes in lipoma. Virchows Arch; 2005 Nov;447(5):855-8
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  • The major cytogenetic subgroup of lipomas is characterized by aberrations of chromosome segment 12q13-15, which recombines with a large number of other chromosomal regions.
  • In addition, subsets of other benign solid tumors show aberrations of 12q13-15.
  • For example, HMGA2/LPP has been reported in lipoma, pulmonary chondroid hamartoma, and soft tissue chondroma.
  • [MeSH-major] Gene Fusion. HMGA2 Protein / genetics. Lipoma / genetics. NFI Transcription Factors / genetics. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Adult. Chromosomes, Human, Pair 12. Chromosomes, Human, Pair 9. DNA, Neoplasm / analysis. Gene Rearrangement. Humans. Male. Reverse Transcriptase Polymerase Chain Reaction. Sequence Analysis, DNA

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  • (PMID = 16133369.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / HMGA2 Protein; 0 / NFI Transcription Factors; 0 / NFIB protein, human
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17. Mosquera JM, Fletcher CD: Expanding the spectrum of malignant progression in solitary fibrous tumors: a study of 8 cases with a discrete anaplastic component--is this dedifferentiated SFT? Am J Surg Pathol; 2009 Sep;33(9):1314-21
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  • Dedifferentiation is a well recognized, if sometimes controversial, form of tumor progression in certain types of soft tissue and bone sarcoma, and confers a worse prognosis when compared with the low-grade counterpart.
  • To date, dedifferentiation has not been described in solitary fibrous tumor (SFT).
  • Two cases were intrathoracic, 2 were located in the deep soft tissue of thigh, and single cases were located in the omentum, scalp, retroperitoneum, and abdominal wall.
  • In addition to typical features of benign-appearing SFT there was an abrupt transition to nondistinctive high-grade sarcoma in all cases.
  • One patient with an 11.5 cm intrathoracic tumor is alive with disease at 58 months after recurrence and metastasis.
  • Our results demonstrate that dedifferentiation in SFT, comparable with that in other low grade/intermediate soft-tissue tumors, poses a higher risk of tumor recurrence and/or metastasis, most notably in large and deep-seated tumors.
  • Similar to other dedifferentiated sarcomas, abrupt transition between low grade and high-grade areas is typically observed with loss of CD34 positivity.
  • The p53 and p16 overexpression in the high-grade component is common as in other dedifferentiated lesions, perhaps pertaining to the underlying molecular mechanism.
  • [MeSH-major] Cell Dedifferentiation. Disease Progression. Soft Tissue Neoplasms / pathology. Solitary Fibrous Tumors / secondary
  • [MeSH-minor] Adult. Aged. Anaplasia / genetics. Anaplasia / pathology. Antigens, CD34 / metabolism. Biomarkers, Tumor / metabolism. Chromosome Aberrations. Comparative Genomic Hybridization. DNA, Neoplasm / analysis. Female. Humans. Male. Middle Aged. Neoplasm Proteins / metabolism. Sarcoma / genetics. Sarcoma / metabolism. Sarcoma / secondary. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 19718788.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Neoplasm Proteins; 0 / P16 protein, human; 0 / Tumor Suppressor Protein p53
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18. Horvai AE, Kramer MJ, Garcia JJ, O'Donnell RJ: Distribution and prognostic significance of human telomerase reverse transcriptase (hTERT) expression in giant-cell tumor of bone. Mod Pathol; 2008 Apr;21(4):423-30
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  • [Title] Distribution and prognostic significance of human telomerase reverse transcriptase (hTERT) expression in giant-cell tumor of bone.
  • Giant-cell tumor of bone is considered a benign, locally aggressive and rarely metastasizing neoplasm of bone.
  • However, recent evidence suggests that activity of the telomerase enzyme complex correlates with recurrence in giant-cell tumor, although the subset of cells with telomerase activity in these heterogeneous tumors has not been defined.
  • In the present study, we investigated whether immunostaining for human telomerase reverse transcriptase, a component of the telomerase complex, correlates with outcome in giant-cell tumor and the distribution of telomerase reverse transcriptase staining in these tumors.
  • We analyzed 58 cases of giant-cell tumor for the presence and pattern of telomerase reverse transcriptase immunostaining, presence of soft tissue involvement and the type of initial surgery, and correlated these findings with recurrence-free survival and metastasis-free survival.
  • Furthermore, positive telomerase reverse transcriptase immunohistochemistry correlated with recurrence-free survival (P=0.02), whereas the presence of soft tissue extension (P=0.3) and the type of initial surgery (P=0.2) did not.
  • Only soft-tissue extension significantly correlated with metastasis-free survival (P=0.003).
  • Therefore, telomerase reverse transcriptase expression may predict recurrence in giant-cell tumor insofar as positive immunostaining correlates with shorter recurrence-free survival and may be a useful prognostic marker to stratify patients to more aggressive treatment protocols.
  • [MeSH-major] Biomarkers, Tumor / analysis. Bone Neoplasms / enzymology. Giant Cell Tumor of Bone / enzymology. Telomerase / biosynthesis
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Prognosis

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  • (PMID = 18204433.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
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19. Gleason BC, Fletcher CD: Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential. Am J Surg Pathol; 2008 Mar;32(3):354-62
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  • [Title] Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential.
  • Benign fibrous histiocytoma (FH) is one of the most common mesenchymal neoplasms of the skin.
  • Deep benign FH is an uncommon and poorly recognized clinical subtype that arises in subcutaneous or deep soft tissue.
  • Only a single small series of these neoplasms has been published, and their clinical behavior is not well characterized.
  • The most common anatomic location was the extremities (58%); the remainder arose on the head and neck (22%), trunk (11%), and in the deep soft tissue of the retroperitoneum, mediastinum, or pelvis (9%).
  • All lesions arising in nonvisceral soft tissue were subcutaneous.
  • Multinucleate giant cells, osteoclastic giant cells, and/or foam cells were present in 59% of cases, whereas the other 41% were cytologically monomorphic, often resembling cellular FH.
  • Other common findings included a hemangiopericytomalike vascular pattern (42%) and stromal hyalinization (39%).
  • Of the 37 patients for whom clinical follow-up was available (median, 40 mo), 8 (22%) had a local recurrence; in all 8 cases, the tumor had been marginally or incompletely excised.
  • The metastasizing tumors were large (6 and 9 cm) and 1 had tumor necrosis but they were otherwise histologically identical to the nonmetastasizing lesions.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Neoplasm Metastasis / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Actins / analysis. Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD34 / analysis. Child. Desmin / analysis. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mitosis. Necrosis. Neoplasm Recurrence, Local

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  • (PMID = 18300816.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD34; 0 / Desmin
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20. Sheff JS, Wang S: Extraskeletal osteochondroma of the foot. J Foot Ankle Surg; 2005 Jan-Feb;44(1):57-9
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  • An extraskeletal osteochondroma is an infrequently encountered benign cartilaginous tumor with a predilection for the hands and feet that usually does not exceed 3 cm in diameter.
  • This diagnosis can be misleading because it bears the same name as the osseous neoplasm more commonly referred to as an exostosis.
  • The authors present an unusual case of a painful enlarging mass in the foot of a 28-year-old man who was later diagnosed as having an extraskeletal osteochondroma measuring in excess of 4 cm.
  • [MeSH-major] Foot Diseases / pathology. Osteochondroma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 15704084.001).
  • [ISSN] 1067-2516
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Kepka L, Suit HD, Goldberg SI, Rosenberg AE, Gebhardt MC, Hornicek FJ, Delaney TF: Results of radiation therapy performed after unplanned surgery (without re-excision) for soft tissue sarcomas. J Surg Oncol; 2005 Oct 1;92(1):39-45
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  • [Title] Results of radiation therapy performed after unplanned surgery (without re-excision) for soft tissue sarcomas.
  • BACKGROUND AND PURPOSE: For soft tissue sarcomas (STS), some patients undergo an "unplanned surgery," non-oncologic resection for presumed benign tumor.
  • Tumor characteristics: location, lower extremity (63%), upper extremity (27%), other (10%); median tumor size, 5 cm; grade-G1 (19%), G2 (49%), G3 (32%); AJCC stage (2002)-I (19%), II (54%), III (27%).
  • Depth in the relation to the fascia, tumor size, and AJCC stage significantly influenced local recurrence- and distant metastasis-free survival.
  • [MeSH-minor] Adolescent. Adult. Aged. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local. Radiotherapy / adverse effects. Radiotherapy Dosage. Retrospective Studies. Survival Analysis. Treatment Failure

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  • (PMID = 16180232.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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22. Rubin BP, Fletcher CD, Inwards C, Montag AG, Peabody T, Qualman SJ, Rosenberg AE, Weiss S, Krausz T, College of American Pathologists: Protocol for the examination of specimens from patients with soft tissue tumors of intermediate malignant potential, malignant soft tissue tumors, and benign/locally aggressive and malignant bone tumors. Arch Pathol Lab Med; 2006 Nov;130(11):1616-29
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Protocol for the examination of specimens from patients with soft tissue tumors of intermediate malignant potential, malignant soft tissue tumors, and benign/locally aggressive and malignant bone tumors.
  • [MeSH-major] Bone Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Humans. Lymph Nodes / pathology. Neoplasm Metastasis / pathology. Neoplasm Staging

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  • [CommentIn] Arch Pathol Lab Med. 2007 May;131(5):680-1; author reply 681-2 [17488149.001]
  • (PMID = 17076523.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline
  • [Publication-country] United States
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23. Diniz MB, Giro Elisa MA, Zuanon Angela CC, Costa CA, Hebling J: Congenital epulis: a rare benign tumor in the newborn. J Indian Soc Pedod Prev Dent; 2010 Jul-Sep;28(3):230-3
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  • [Title] Congenital epulis: a rare benign tumor in the newborn.
  • Congenital epulis (CE) of the newborn is a rare benign soft tissue tumor that presents at birth.
  • A decisive diagnosis is made by histopathologic analysis as other newborn lesions can be incorrectly diagnosed as CE.
  • This article presents a case report of a female infant who presented a fibrotic mass in the primary lateral incisor and canine region of the maxillary alveolar ridge.
  • [MeSH-major] Gingival Neoplasms / congenital. Gingival Neoplasms / pathology

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  • (PMID = 21157060.001).
  • [ISSN] 0970-4388
  • [Journal-full-title] Journal of the Indian Society of Pedodontics and Preventive Dentistry
  • [ISO-abbreviation] J Indian Soc Pedod Prev Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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24. McGough RL, Rutledge J, Lewis VO, Lin PP, Yasko AW: Impact severity of local recurrence in giant cell tumor of bone. Clin Orthop Relat Res; 2005 Sep;438:116-22
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  • [Title] Impact severity of local recurrence in giant cell tumor of bone.
  • We retrospectively reviewed 183 consecutive patients diagnosed with giant cell tumor at the three most common sites (distal femur, proximal tibia, and distal radius) to determine the pattern of local tumor recurrence and the impact severity of the recurrence on adjacent joint function.
  • The primary tumor was treated in all patients with intralesional excision of tumor by curettage.
  • Twenty-three of the patients had their first surgery at our institution, and 22 had been referred from other institutions after the development of local recurrence.
  • The intrainstitutional recurrences were salvaged by a repeat curettage (n = 12) or en bloc osteoarticular resection (n = 10) for bone recurrences and wide local excision for soft tissue recurrence (n = 1).
  • Incomplete initial surgery, a delay in diagnosis of the recurrence of greater than 6 months, and subchondral recurrence of tumor were contributing factors in the failure to salvage the joint.
  • Despite its benign histology, giant cell tumor of bone is an aggressive tumor that demands meticulous attention to surgical detail and close postoperative surveillance for successful local tumor control and durable, joint-preserving function.
  • [MeSH-major] Bone Neoplasms / pathology. Giant Cell Tumor of Bone / pathology. Neoplasm Recurrence, Local

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  • (PMID = 16131879.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Shukla R, Pooja B, Radhika S, Nijhawan R, Rajwanshi A: Fine-needle aspiration cytology of extramammary neoplasms metastatic to the breast. Diagn Cytopathol; 2005 Apr;32(4):193-7
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  • [Title] Fine-needle aspiration cytology of extramammary neoplasms metastatic to the breast.
  • Metastatic breast neoplasms diagnosed over a 6-yr period from 1997 to 2002 were retrieved from the database of the Department of Cytopathology and the clinical, cytopathological, histochemical, and immunohistochemical findings were correlated with the histopathology of the primary tumor.
  • Fifteen cases of metastatic breast neoplasms were encountered constituting 1.47% of all malignant tumors of the breast diagnosed on FNA.
  • The preaspiration clinical diagnosis was either a benign breast lump or a malignancy (primary vs. metastatic).
  • The breast lump was the initial presentation in four cases and the cytodiagnosis of a metastatic malignancy lead to the subsequent detection of the primary malignancy.
  • The adult cases included two cases each of melanoma, small-cell carcinoma, and myeloma; one case of choriocarcinoma; and three cases of soft-tissue sarcomas.
  • The presence of unusual cytomorphological patterns on breast FNA should alert the cytopathologist to the possibility of a metastatic breast neoplasm, even if not suspected clinically.
  • A detailed history of the patient, clinical correlation, and immunocytochemistry helps in establishing an accurate diagnosis, which avoids unnecessary surgery and ensures appropriate treatment.
  • [MeSH-major] Breast / pathology. Breast Neoplasms, Male / pathology. Breast Neoplasms, Male / secondary
  • [MeSH-minor] Adolescent. Adult. Biopsy, Fine-Needle. Child. Female. Humans. Male. Middle Aged. Neoplasm Metastasis / pathology. Predictive Value of Tests

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15754368.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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26. Henry CJ, Brewer WG Jr, Whitley EM, Tyler JW, Ogilvie GK, Norris A, Fox LE, Morrison WB, Hammer A, Vail DM, Berg J, Veterinary Cooperative Oncology Group (VCOG): Canine digital tumors: a veterinary cooperative oncology group retrospective study of 64 dogs. J Vet Intern Med; 2005 Sep-Oct;19(5):720-4
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  • Risk factors examined included age, weight, sex, tumor site (hindlimb or forelimb), local tumor (T) stage, metastases, tumor type, and treatment modality.
  • Other diagnoses included malignant melanoma (MM) (n = 10; 15.6%), osteosarcoma (OSA) (n = 4; 6.3%), hemangiopericytoma (n = 3; 4.7%), benign soft tissue tumors (n = 5; 7.8%), and malignant soft tissue tumors (n = 9; 14%).
  • None of the patient variables assessed, including age, sex, tumor type, site, and stage, had a significant impact on ST.
  • Although metastasis at diagnosis correlated with a shorter LDFI, it did not have a significant impact on ST.
  • On the basis of these findings, early surgical intervention is advised for the treatment of dogs with digital tumors, regardless of tumor type or the presence of metastatic disease.


27. Mandal RV, Duncan LM, Austen WG Jr, Nielsen GP: Infiltrating intramuscular spindle cell lipoma of the face. J Cutan Pathol; 2009 Oct;36 Suppl 1:70-3
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  • Spindle cell lipoma is a benign lipomatous tumor, which usually arises on the back of the neck, shoulder or upper back of males in the third to seventh decade of life.
  • We report herein an unusual infiltrating intramuscular spindle cell lipoma arising in the nose of a 53-year-old man.
  • Histologically, a proliferation of mature adipocytes, ropey collagen fibers and spindle cells within a myxoid stroma was present in the subcutaneous tissue and infiltrated between skeletal muscle fibers.
  • [MeSH-major] Lipoma / pathology. Neoplasm Recurrence, Local / pathology. Nose Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19187113.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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28. Bandyopadhyay S, Basturk O, Coban I, Thirabanjasak D, Liang H, Altinel D, Adsay NV: Isolated solitary ducts (naked ducts) in adipose tissue: a specific but underappreciated finding of pancreatic adenocarcinoma and one of the potential reasons of understaging and high recurrence rate. Am J Surg Pathol; 2009 Mar;33(3):425-9
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  • [Title] Isolated solitary ducts (naked ducts) in adipose tissue: a specific but underappreciated finding of pancreatic adenocarcinoma and one of the potential reasons of understaging and high recurrence rate.
  • The glandular units of invasive carcinoma are often well formed with well-polarized cells, appearing deceptively benign.
  • We recently noted isolated solitary ductal units (ISDs) in adipose tissue to be a reliable indicator of adenocarcinoma.
  • ISD was defined as a solitary gland lying individually in adipose tissue, either directly abutting adipocytes or separated from them by only a thin rim of fibromuscular tissue.
  • ISDs were often located in histologic sections taken for the evaluation of the retroperitoneal margin and pancreatic-free surfaces where adipose tissue is more abundant.
  • In conclusion, ISD lying in adipose tissue unaccompanied by other elements, present in 47.6% of pancreatic resections when peripancreatic soft tissues away from the tumor are sampled, is a very specific finding for carcinoma that may be instrumental in the diagnosis and staging of carcinoma as well as margin evaluation.
  • [MeSH-major] Adipose Tissue / pathology. Carcinoma, Pancreatic Ductal / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Pancreatitis / pathology

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  • (PMID = 19092633.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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29. Landa J, Schwartz LH: Contemporary imaging in sarcoma. Oncologist; 2009 Oct;14(10):1021-38
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  • Sarcomas are a heterogeneous group of >50 subtypes of neoplasm.
  • It is imperative to obtain appropriate imaging of these tumors in order to adequately assess, characterize, and stage bone and soft tissue sarcomas.
  • Anatomic imaging such as radiographs, computed tomography, and magnetic resonance imaging (MRI) remain the foundation for both biopsy planning and postoperative evaluation of these neoplasms.
  • Newer radiopharmaceuticals, such as (18)F-fluorodeoxythymidine, are being developed to assist in the differentiation between benign and low-grade malignant neoplasms.
  • [MeSH-major] Bone Neoplasms / diagnosis. Fluorodeoxyglucose F18. Positron-Emission Tomography. Radiopharmaceuticals. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Magnetic Resonance Imaging. Male. Neoplasm Metastasis / diagnosis. Neoplasm Staging. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • (PMID = 19789392.001).
  • [ISSN] 1549-490X
  • [Journal-full-title] The oncologist
  • [ISO-abbreviation] Oncologist
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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30. Liao KS, Huang WT, Yang SF, Chien SH, Hsieh TJ, Chai CY, Wu CC: Intramuscular low-grade fibromyxoid sarcoma: a case report. Kaohsiung J Med Sci; 2009 Aug;25(8):448-54
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  • Low-grade fibromyxoid sarcoma (LGFMS) is a rare neoplasm that commonly arises in the deep soft tissues of the lower extremities, particularly in the thigh.
  • Although LGFMS has a deceptively benign histologic appearance, local recurrence and late metastases have frequently been reported.
  • Diagnosis of LGFMS is still difficult because of its characteristic bland-looking histologic features that can be confused with other benign or low-grade fibromyxoid lesions.
  • Although immunohistochemical staining can offer an overview of the differential diagnosis of myxoid tumors of soft tissue, it is sometimes limited for diagnosis of LGFMS.
  • However, recent cytogenetic and molecular analyses have provided significant improvements in the diagnosis of LGFMS.
  • In conclusion, diagnosis of LGFMS can be challenging in routine practice in surgical pathology because of its bland-looking features.
  • [MeSH-major] Fibrosarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 19605340.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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31. Bekler H, Gokce A, Beyzadeoglu T: Chondroid syringoma of the hand: a rare localization. Handchir Mikrochir Plast Chir; 2007 Dec;39(6):430-2
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  • Chondroid syringoma is a rare benign neoplasm of the sweat glands that usually occurs in the head and neck region.
  • We describe a 18-year-old male patient with a benign chondroid syringoma that occurred at an unusual site, leading to compression symptoms of the ulnar nerve causing symptoms at the hypothenar region of the right hand.
  • Although it is a rare tumor at an unusual site, it should be included in the differential diagnosis of the hand tumors.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adolescent. Biopsy. Humans. Image Enhancement. Magnetic Resonance Imaging. Male. Muscle, Skeletal / pathology. Neoplasm Invasiveness

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  • (PMID = 18058676.001).
  • [ISSN] 0722-1819
  • [Journal-full-title] Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der Peripheren Nerven und Gefässe : Organ der Vereinigung der Deutschen Plastischen Chirurgen
  • [ISO-abbreviation] Handchir Mikrochir Plast Chir
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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32. Klijanienko J, Caillaud JM, Lagacé R: Cytohistologic correlations in schwannomas (neurilemmomas), including "ancient," cellular, and epithelioid variants. Diagn Cytopathol; 2006 Aug;34(8):517-22
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  • Schwannoma accounts for one of the most common benign mesenchymal neoplasms of soft tissues.
  • Original cytologic diagnosis was schwannoma in 13 (38.2%) cases, benign soft tissue tumor in 11 (32.4%), pleomorphic adenoma in 2 (6%) cases, angioma in 1 (2.9%) case, nodular fasciitis in 1 (2.9%) case, suspicious in 3 (8.8%) cases, and not satisfactory in 3 (8.8%) cases.
  • Similarly, cyto-nuclear atypia was more frequent in classical subtype than in other subtypes.
  • Schwannoma should be differentiated from well-differentiated malignant peripheral nerve sheath tumor, neurofibroma, and pleomorphic adenoma, in the last instance particularly for head and neck lesions.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Neurilemmoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Reproducibility of Results

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16850489.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Leinung S, Möbius C, Udelnow A, Hauss J, Würl P: Histopathological outcome of 597 isolated soft tissue tumors suspected of soft tissue sarcoma: a single-center 12-year experience. Eur J Surg Oncol; 2007 May;33(4):508-11
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  • [Title] Histopathological outcome of 597 isolated soft tissue tumors suspected of soft tissue sarcoma: a single-center 12-year experience.
  • BACKGROUND: The aim of this present report was to analyze the patients referred to us with the presumptive diagnosis of soft tissue sarcoma (STS).
  • METHODS: We reviewed all patients referred to us with suspected soft tissue sarcoma (STS) of the extremities or trunk over a 12-year period.
  • RESULTS: We treated 597 patients with soft tissue tumors.
  • Open biopsy revealed soft tissue sarcoma in 318 cases, benign mesenchymal tumor in 124 cases and isolated metastases (ISTM) from carcinomas in 98 patients; other pathologies were found in 57 patients.
  • CONCLUSIONS: In our collective with soft tissue tumor, 50% of the patients had the diagnosis of soft tissue sarcoma, 20% presented with a metastasis of carcinoma and 20% had a benign tumor.
  • Referring to our results, in patients with the presumptive diagnosis of soft tissue sarcomas, soft tissue metastasis of a primary carcinoma was unexpectedly common, indicating that greater consideration should be given to this differential diagnosis.
  • [MeSH-major] Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy. Female. Humans. Male. Middle Aged. Neoplasm Metastasis

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  • (PMID = 17081724.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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34. Taher A, Pushpanathan C: Plexiform fibrohistiocytic tumor: a brief review. Arch Pathol Lab Med; 2007 Jul;131(7):1135-8
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  • [Title] Plexiform fibrohistiocytic tumor: a brief review.
  • Plexiform fibrohistiocytic tumor is a rare mesenchymal neoplasm of intermediate malignancy, first reported by Enzinger and Zhang in 1988.
  • The tumor usually involves the upper limbs as a slow-growing, painless mass.
  • The tumor has a high local recurrence rate but metastasizes only rarely.
  • Histologically, the tumor is characterized by poorly demarcated dermal or subcutaneous mass with multinodular plexiform growth and fibrohistiocytic cytomorphology.
  • The tumor displays uniform immunoreactivity for vimentin and CD68.
  • Ultrastructurally, the tumor cells have features of myofibroblasts and histiocyte-like cells.
  • Complete surgical resection of the tumor, preferably with wider margins, is required to prevent local recurrence.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Male. Middle Aged. Prognosis

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  • (PMID = 17617005.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 20
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35. Rekhi B, Bhatnagar D, Bhatnagar A, Saxena S: Cytomorphological study of soft tissue neoplasms: role of fluorescent immunocytochemistry in diagnosis. Cytopathology; 2005 Oct;16(5):219-26
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytomorphological study of soft tissue neoplasms: role of fluorescent immunocytochemistry in diagnosis.
  • OBJECTIVES: Exact categorization of soft tissue tumours (STTs) on smears requires application of various ancillary techniques.
  • This study was aimed at evaluating the role of fluorescent immunocytochemistry (FICC) in cyto-diagnosis of 30 STT cases.
  • METHODS: Thirty cases of soft tissue tumours were included in the present study.
  • RESULTS: Among the 30 cases in the present study, unaided cytological diagnoses ranged from 'spindle cell' tumour in four (13.3%) cases, benign and malignant spindle cell tumour in 17 (56.6%) cases, to malignant mesenchymal tumour in nine (30%) cases.
  • FICC helped in further correct categorization of 25/30 (83.3%) cases viz. leiomyoma (three), benign neurogenic tumour (six), schwannoma (one), dermatofibrosarcoma protuberans (three), synovial sarcoma (two), rhabdomyosarcoma (two), malignant fibrous histiocytoma (five) and malignant peripheral nerve sheath tumour (three).
  • Aggressive fibromatosis was found to be a missed diagnosis in two cases.
  • Overall concordance between cyto-diagnosis with FICC, and histopathology results was 83.3% (P < 0.05).
  • CONCLUSION: Fluorescent immunocytochemistry is a significant ancillary technique for making a rapid and specific diagnosis of STT, as required for their timely management.
  • Incorporation of a wide panel of antibody markers with clinico-cytological correlation is recommended in forming an exact diagnosis in these cases.
  • [MeSH-major] Neoplasm Proteins. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Fluorescent Antibody Technique / methods. Humans

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  • (PMID = 16181307.001).
  • [ISSN] 0956-5507
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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36. Dong MJ, Zhou GY: [Imaging diagnosis of hemangioma in infants]. Shanghai Kou Qiang Yi Xue; 2008 Apr;17(2):221-4
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  • [Title] [Imaging diagnosis of hemangioma in infants].
  • Hemangioma is the most commonly benign tumor of soft tissue tumors in infants.
  • In this article, the current situation of application with all imaging examinations used in diagnosis of hemangioma is reviewed.
  • [MeSH-major] Hemangioma / diagnosis

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  • (PMID = 18470434.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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37. Ramos-Font C, Santiago Chinchilla A, Rebollo Aguirre AC, Rodríguez Fernández A, Medina Benítez A, Llamas Elvira JM: [Desmoid tumor of the thoraco-abdominal wall characterized with 18F-fluorodeoxyglucose PET/ CT scan. Correlation with magnetic resonance and bone scintigraphy. Review of the literature]. Rev Esp Med Nucl; 2009 Mar-Apr;28(2):70-3
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  • [Title] [Desmoid tumor of the thoraco-abdominal wall characterized with 18F-fluorodeoxyglucose PET/ CT scan. Correlation with magnetic resonance and bone scintigraphy. Review of the literature].
  • [Transliterated title] Tumor desmoide de la pared torácico-abdominal. Caracterización con PET-TAC con 18F-fluorodesoxiglucosa y correlación con resonancia magnética y gammagrafía ósea. Revisión de la literatura.
  • Desmoid tumours are uncommon benign tumours but with aggressive behaviour, resulting from the proliferation of well-differentiated fibroblasts.
  • Clinically, they present as a painless firm soft tissue mass.
  • When planning treatment, it is important to assess the correct tumour extent to permit curative radical surgery minimizing possible local recurrence.
  • The role of nuclear medicine techniques, such as bone scintigraphy, or more recently FDG-PET, has not been defined in the evaluation of these neoplasms.
  • We present the case of a patient with a desmoid tumour of the abdominal-chest wall and we review the related literature.
  • [MeSH-major] Abdominal Neoplasms / radionuclide imaging. Abdominal Wall / radionuclide imaging. Bone Neoplasms / radionuclide imaging. Fibromatosis, Aggressive / radionuclide imaging. Fluorine Radioisotopes. Fluorodeoxyglucose F18. Muscle Neoplasms / radionuclide imaging. Positron-Emission Tomography. Radiopharmaceuticals. Rectus Abdominis / radionuclide imaging. Ribs / radionuclide imaging. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness. Thoracic Wall / pathology. Thoracic Wall / radiography. Thoracic Wall / radionuclide imaging

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  • (PMID = 19406052.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] spa
  • [Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Fluorine Radioisotopes; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 22
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38. Ayadi-Kaddour A, Ben Slama S, Braham E, Abid L, Ismail O, Smati B, Djilani H, El Mezni F: [Desmoplastic fibroma of the rib: two case reports]. Ann Pathol; 2005 Oct;25(5):398-401
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  • [Transliterated title] Le fibrome desmoplastique de la côte: à propos de deux observations.
  • Desmoplastic fibroma is a very rare primary tumor of bone, closely related to aggressive fibromatosis of soft tissue.
  • Although considered a benign lesion, it can be very aggressive locally and has a high rate of local recurrence after incomplete surgical excision.
  • Histological examination after surgical resection revealed that the tumor consisted of spindle cells with small, elongated nuclei in a background of numerous collagen fibers and infiltrating lamellar bone.
  • We also discuss histological differential diagnosis as well as clinical features and the radiological and pathologic findings of this rare disease.
  • [MeSH-major] Bone Neoplasms / pathology. Fibroma, Desmoplastic / pathology. Ribs / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Collagen / analysis. Diagnosis, Differential. Female. Fibroblasts / pathology. Humans. Lung / pathology. Lung / surgery. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Proteins / analysis. Neoplasm Recurrence, Local / surgery. Pneumonectomy. Thoracic Wall / pathology

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  • (PMID = 16498294.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 9007-34-5 / Collagen
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39. Manor E, Sion-Vardy N, Nash M, Bodner L: Angiomyoma of buccal vestibule: a rare case with a normal karyotype. J Laryngol Otol; 2007 Dec;121(12):1210-2
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  • Angiomyoma is an uncommon, benign, soft tissue tumour characterised by bundles of smooth muscle cells intermixed with numerous vascular channels, which usually develops in the lower extremities.
  • [MeSH-major] Angiomyoma / diagnosis. Mouth Neoplasms / diagnosis
  • [MeSH-minor] Adult. Cheek. Diagnosis, Differential. Humans. Male

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  • (PMID = 17524173.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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40. Sherwani RK, Kumar A: Solitary fibrous tumour of the lower leg: an uncommon site with atypical histopathological features. BMJ Case Rep; 2010;2010
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  • [Title] Solitary fibrous tumour of the lower leg: an uncommon site with atypical histopathological features.
  • On local examination, the overlying skin was normal and the mass was soft to firm in consistency, non-tender and freely mobile with no fixity to underlying structures.
  • MRI revealed a lobulated mass with central areas of necrosis and no involvement of underlying muscles and neurovascular bundles suggesting a benign soft tissue tumour.
  • The tumour was totally excised and submitted for histopathological examination, which, along with immunopositivity for CD34, CD99 and focally for Bcl2, led to a confirmatory diagnosis of solitary fibrous tumour with atypical histopathological features of increased mitosis and necrosis.
  • [MeSH-major] Leg / pathology. Soft Tissue Neoplasms / pathology. Solitary Fibrous Tumors / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Male

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  • [Cites] Cancer. 2002 Feb 15;94(4):1057-68 [11920476.001]
  • [Cites] Am J Surg Pathol. 1998 Dec;22(12):1501-11 [9850176.001]
  • [Cites] BMC Surg. 2006;6:10 [16824225.001]
  • (PMID = 22791854.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC3027392
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41. Duncan SF, Athanasian EA, Antonescu CR, Roberts CC: Resolution of Nodular Fasciitis in the Upper Arm. Radiol Case Rep; 2006;1(1):17-20
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  • Nodular fasciitis is a benign fibroblastic lesion that was historically misdiagnosed as a malignant neoplasm.
  • After the diagnosis is established histologically, observation is the suggested treatment.
  • We present the case of a patient who had a large soft-tissue tumor in the upper arm with a clinical picture indicative of sarcoma, which ultimately was diagnosed as nodular fasciitis.

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  • (PMID = 27298674.001).
  • [ISSN] 1930-0433
  • [Journal-full-title] Radiology case reports
  • [ISO-abbreviation] Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC4891406
  • [Keywords] NOTNLM ; MRI, magnetic resonance imaging
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42. Rajasekhar G, Mushtaq M, Vura NG, Shekar R, Kumar S: Condyloma acuminatum associated with odontogenic myxoma: a case report. J Maxillofac Oral Surg; 2009 Dec;8(4):384-7
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  • In oral cavity the condition manifests as soft pink nodules which proliferate and coalesce rapidly to form diffuse papillomatous clusters of varying size.
  • Odontogenic myxoma is a rare tumor of jaws which occurs in the tooth-bearing areas of the mandible and maxilla.
  • It is an uncommon, benign, but locally aggressive neoplasm.
  • This case report highlights a 17-year-old girl with two lesions in oral cavity with soft tissue growth on the palate which has been diagnosed as Condyloma Acuminatum, treated by surgical excision and a large swelling on the right side of the mandible in the same patient diagnosed as odontogenic myxoma where marginal resection was performed.

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  • [Cites] Br J Vener Dis. 1978 Dec;54(6):433-40 [581655.001]
  • [Cites] Oral Surg Oral Med Oral Pathol. 1968 Oct;26(4):434-40 [5244772.001]
  • [Cites] Dermatol Surg. 2003 Mar;29(3):300-3 [12614429.001]
  • [Cites] Int J Oral Maxillofac Surg. 2008 Dec;37(12):1159-61 [18774261.001]
  • [Cites] Br J Vener Dis. 1983 Oct;59(5):325-6 [6311323.001]
  • [Cites] Jpn J Clin Oncol. 1996 Dec;26(6):393-7 [9001342.001]
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  • [Cites] J Contemp Dent Pract. 2006 Feb 15;7(1):117-24 [16491154.001]
  • [Cites] J Am Dent Assoc. 2003 Mar;134(3):331-4 [12699047.001]
  • (PMID = 23139551.001).
  • [ISSN] 0972-8279
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3454105
  • [Keywords] NOTNLM ; Autoinoculation / Condyloma acuminatum / HPV-6 / Odontogenic myxoma / Palate / Young adult
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43. Segal NH, Blachere NE, Shiu HY, Leejee S, Antonescu CR, Lewis JJ, Wolchok JD, Houghton AN: Antigens recognized by autologous antibodies of patients with soft tissue sarcoma. Cancer Immun; 2005 Mar 4;5:4
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  • [Title] Antigens recognized by autologous antibodies of patients with soft tissue sarcoma.
  • In order to identify tumor antigens in soft tissue sarcoma (STS), sera from four patients with malignant fibrous histiocytoma (MFH), gastrointestinal stromal tumor (GIST), pleomorphic liposarcoma, and dedifferentiated liposarcoma were screened against cDNA libraries derived from autologous tumor.
  • Using oligonucleotide microarray technology, most genes were variably expressed across a panel of 16 benign specimens and 41 STSs of different histologies.
  • [MeSH-major] Antibodies, Neoplasm / immunology. Antigens, Neoplasm / immunology. Sarcoma / immunology

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  • (PMID = 15745419.001).
  • [ISSN] 1424-9634
  • [Journal-full-title] Cancer immunity
  • [ISO-abbreviation] Cancer Immun.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-47179
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm; 0 / Antigens, Neoplasm; 0 / Immunoglobulin G
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44. Laga AC, Tajirian AL, Islam MN, Bhattacharyya I, Cohen DM, Plamondon CJ, Robinson-Bostom L: Myopericytoma: report of two cases associated with trauma. J Cutan Pathol; 2008 Sep;35(9):866-70
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  • Myopericytoma is a rare, recently described tumor demonstrating a hemangiopericytoma-like vascular pattern.
  • We present two cases of myopericytoma associated with trauma: a 64-year-old man who developed several nodules on his nose four months after sustaining multiple abrasions to his forehead and nose, and a 72-year-old woman with a solitary growth in the alveolar ridge of unknown duration.
  • Despite sharing morphologic features with angioleiomyoma, myofibroma and glomus tumor, myopericytoma is thought to represent a distinct perivascular myoid neoplasm of skin and soft tissues.
  • The tumor is characterized by a radial and perivascular arrangement of ovoid, spindled to round neoplastic cells that are immunoreactive to alpha-smooth muscle actin, often for h-caldesmon as well as smooth muscle myosin-heavy chain, and usually negative for desmin antibodies.
  • Most cases of myopericytoma are benign, however, local recurrence and malignancy have recently been reported, Myopericytoma can be multifocal involving a single or multiple anatomic regions, and tends to occur in dermal and superficial soft tissues of adults primarily on the extremities.
  • Our cases are unusual examples of myopericytoma manifesting as multiple nodules on the nose, and a solitary growth on the buccal mucosa after trauma.
  • [MeSH-major] Hemangiopericytoma / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology. Wounds and Injuries / complications
  • [MeSH-minor] Actins / metabolism. Aged. Biomarkers, Tumor / metabolism. Calcium-Binding Proteins / metabolism. Female. Humans. Male. Microfilament Proteins / metabolism. Middle Aged. Mouth Mucosa / injuries. Myosin Heavy Chains / metabolism. Nose / injuries. Treatment Outcome

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  • (PMID = 18494828.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Calcium-Binding Proteins; 0 / Microfilament Proteins; 0 / calponin; EC 3.6.4.1 / Myosin Heavy Chains
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45. Meng GZ, Zhang HY, Bu H, Zhang XL, Pang ZG, Ke Q, Liu X, Yang G: Myofibroblastic sarcomas: a clinicopathological study of 20 cases. Chin Med J (Engl); 2007 Mar 5;120(5):363-9
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  • BACKGROUND: Myofibroblastic sarcoma was used to be a controversial neoplasm.
  • METHODS: The paraffin-embedded tissue samples from 20 cases of patients with myofibroblastic sarcoma were stained immunohistochemically, and 5 cases examined by electron microscopy.
  • RESULTS: Histologically, the tumors were composed of slender spindle cells with eosinophilic cytoplasm, and fusiform, tapering, wavy, or plump ovoid; vesicular nuclei and a small central eosinophilic nucleoli.
  • Immunohistochemically, the tumor cells expressed smooth muscle actin (18/20), muscle specific actin (16/20), fibronectin (20/20) and desmin (2/20).
  • Ultrastructurally, the tumor cells revealed abundant rough endoplasmic reticulum and longitudinally arranged fine filaments with focal densities in the cytoplasm.
  • CONCLUSIONS: Myofibroblastic sarcomas, which exhibit diverse histological appearance, can easily be misdiagnosed as benign tumors.
  • [MeSH-major] Fibrosarcoma / pathology. Myosarcoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 17376304.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Desmin
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46. Patsiaoura K, Anagnostou E, Benis N: Intramuscular myxoma of the nasal vestibule. Auris Nasus Larynx; 2010 Feb;37(1):100-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Intramuscular myxoma is an uncommon benign soft tissue neoplasm and a distinct histopathological entity within the heterogeneous group of myxomas.
  • We report on a case of a myxoma within the mimetic muscles of the nasal and mouth region in a 52-year-old man.
  • The tumor was surgically removed and the patient is free of recurrence or complications 8 months after treatment.
  • To the very best of our knowledge, there is no report of this neoplasm located within the nasal and oral mimetic muscles.
  • [MeSH-major] Muscle, Skeletal / pathology. Myxoma / pathology. Paranasal Sinus Neoplasms / pathology
  • [MeSH-minor] Humans. Male. Middle Aged. Nasal Cavity. Otorhinolaryngologic Surgical Procedures. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / surgery. Treatment Outcome

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  • [Copyright] Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19414229.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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47. Takahara M, Ichikawa R, Oda Y, Uchi H, Takeuchi S, Moroi Y, Kiryu H, Furue M: Desmoplastic fibroblastoma: a case presenting as a protruding nodule in the dermis. J Cutan Pathol; 2008 Oct;35 Suppl 1:70-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Desmoplastic fibroblastoma is a rare, benign, soft tissue tumor.
  • Histological examination from total excision showed a well-circumscribed tumor in the dermis, which comprised of spindle, oval and stellate cells arranged in a haphazard fashion, accompanied by abundant collagenous stroma and inconspicuous vasculature.
  • Immunohistochemically, the tumor cells were positive for vimentin, and focally positive for alpha-smooth muscle actin and muscle-specific actin, but negative for CD34, S-100 protein, desmin and beta-catenin.
  • We diagnosed this case as desmoplastic fibroblastoma arising in the dermis and superficial subcutaneous tissue.
  • [MeSH-major] Fibroma / pathology. Soft Tissue Neoplasms / pathology

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  • [Copyright] Copyright Blackwell Munksgaard 2008.
  • (PMID = 18544056.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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48. Ferri E, Iaderosa GA, Armato E: Atypical fibroxanthoma of the external ear in a cardiac transplant recipient: case report and the causal role of the immunosuppressive therapy. Auris Nasus Larynx; 2008 Jun;35(2):260-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Atypical fibroxanthoma (AF) is an unusual cutaneous fibrohistiocytic tumour that is most commonly found in ENT sun-exposed areas of elderly males.
  • Cardiac transplant patients have an increased incidence of multiple cutaneous neoplasms, but the AF is uncommon.
  • Although this neoplasm is benign, it may mimic spindle cell carcinoma, squamous cell carcinoma, melanoma and soft tissue sarcoma on histologic examination.
  • Immunohistochemical stains for cytokeratin, alpha-1-antichymotrypsin, S100 protein and vimentin may be helpful in differential diagnosis.
  • We present a case of a cardiac transplant recipient who developed, after multiple cutaneous squamous tumours, an AF of external ear following the prolonged immunosuppressive treatment with cyclosporin.
  • [MeSH-major] Ear Neoplasms / pathology. Ear, External. Heart Transplantation. Histiocytoma, Benign Fibrous / pathology
  • [MeSH-minor] Aged. Cyclosporins. Diagnosis, Differential. Humans. Immunosuppressive Agents / adverse effects. Male. Postoperative Complications

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  • (PMID = 17804184.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cyclosporins; 0 / Immunosuppressive Agents
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49. Cigna E, Carlesimo B, Bistoni G, Conte F, Palumbo F, Scuderi N: The value of clinical diagnosis of digital glomus tumors. Acta Chir Plast; 2008;50(2):55-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The value of clinical diagnosis of digital glomus tumors.
  • Glomus tumors are benign neoplasms that differentiate from the glomus apparatus.
  • This neoplasm is clinically characterized by a typical symptomatological triad: paroxysmal pain, pinpoint pain and hypersensitivity to cold.
  • The diagnosis is usually clinical, but can be confirmed by instrumental tests such as X-ray, MRI, selective arteriography and most commonly by ultrasound, with or without Doppler.
  • Surgical resection of the glomus tumor is the definitive treatment with resolution of all symptoms.
  • The nine most recent cases of glomus tumor underwent surgery after clinical assessment alone.
  • In our opinion clinical examination is the most effective method to diagnose this type of tumor and in selected cases it may be sufficient to undergo surgical therapy.
  • [MeSH-major] Angiography / methods. Fingers. Glomus Tumor / diagnosis. Magnetic Resonance Imaging / methods. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 18807392.001).
  • [ISSN] 0001-5423
  • [Journal-full-title] Acta chirurgiae plasticae
  • [ISO-abbreviation] Acta Chir Plast
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Czech Republic
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50. Ghazali N, Cascarini L, Norris P, Barrett AW, Lavery KM: Perivascular epithelioid cell tumor (PEComa) of the cheek. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Jul;110(1):e26-31
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  • [Title] Perivascular epithelioid cell tumor (PEComa) of the cheek.
  • We present the unusual case of a perivascular epithelioid cell tumor (PEComa) occurring within the cheek of a 32-year-old woman.
  • It mainly affects the abdominopelvic region and rarely occurs in somatic soft tissue or skin.
  • To our knowledge, this is the first reported case of PEComa occurring in the facial cutaneous tissues.
  • Other possible diagnoses considered included benign mesenchymal tumors of smooth muscle or neural origin.
  • The tumor was completely excised, but in view of uncertainty as to how this entity would behave in an unusual location, lifelong follow up is recommended.
  • [MeSH-major] Cheek / pathology. Facial Neoplasms / diagnosis. Perivascular Epithelioid Cell Neoplasms / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Actins / analysis. Adult. Antigens, Neoplasm / analysis. Arterioles / pathology. Diagnosis, Differential. Epithelioid Cells / pathology. Female. Follow-Up Studies. Humans. MART-1 Antigen. Muscle, Smooth, Vascular / pathology. Neoplasm Proteins / analysis

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  • [Copyright] Copyright (c) 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20610292.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Neoplasm Proteins
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51. Dimitrakopoulos I, Lasaridis N, Asimaki A: Primary malignant peripheral nerve sheath tumour in the temporalis muscle. J Craniomaxillofac Surg; 2008 Jul;36(5):300-3
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  • [Title] Primary malignant peripheral nerve sheath tumour in the temporalis muscle.
  • INTRODUCTION: Primary malignant neoplasms of nerve sheath origin are rare, highly aggressive tumours that account for no more than 5% of all soft tissue sarcomas.
  • In the head and neck where the great majority of peripheral nerve neoplasms are benign, as in the rest of the body, malignant peripheral nerve sheath tumours (MPNSTs) are unusual lesions.
  • PATIENT: A case of a large MPNST is reported, which originated in the left temporalis muscle of a 74-year-old man who did not suffer from von Recklinghausen's disease.
  • DISCUSSION: The clinicopathologic properties of this neoplasm have been widely discussed and the emphasis is on the need for its early identification since the tumour's non-specific symptoms may result in delayed diagnosis and treatment.
  • The rarity of the tumour along with its clinical appearance and the vague symptoms may result in delayed referral and thus the tumour being quite large when diagnosed.
  • [MeSH-major] Muscle Neoplasms / pathology. Nerve Sheath Neoplasms / pathology. Temporal Muscle / pathology
  • [MeSH-minor] Aged. Fatal Outcome. Humans. Male. Neoplasm Recurrence, Local / surgery

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  • (PMID = 18367405.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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52. Minagawa T, Matsushita K, Shimada R, Takayama H, Hiraga R, Uehara T, Murata Y: Aggressive angiomyxoma mimicking inguinal hernia in a man. Int J Clin Oncol; 2009 Aug;14(4):365-8
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  • We report the case of a 37-year-old Japanese man who presented with a left lower abdominal mass that was initially interpreted clinically as an inguinal hernia.
  • Local excision was performed, with a preoperative diagnosis of benign soft tissue tumor.
  • Histopathological diagnosis revealed aggressive angiomyxoma (AAM), and no recurrence was observed 6 months after surgery.
  • AAM is a rare tumor which most commonly occurs in the pelvis or perineum of premenopausal women, with extremely rare cases in men.
  • The findings from previously reported cases and our case suggest that AAM should be considered in patients with an inguinal or scrotal swelling with a suspicious soft tissue tumor.
  • [MeSH-major] Hernia, Inguinal / diagnosis. Myxoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Treatment Outcome

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  • [Cites] AJR Am J Roentgenol. 1999 Feb;172(2):435-8 [9930798.001]
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  • (PMID = 19705250.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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53. Nazir SA, Raza SA, Nazir S, Sherwood W, Bowker C, Lakhoo K: Challenges in the prenatal and post-natal diagnosis of mediastinal cystic hygroma: a case report. J Med Case Rep; 2008;2:256
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  • [Title] Challenges in the prenatal and post-natal diagnosis of mediastinal cystic hygroma: a case report.
  • INTRODUCTION: Cystic hygroma is a benign congenital neoplasm that mostly presents as a soft-tissue mass in the posterior triangle of the neck.
  • The diagnosis is often made intra- or postoperatively.
  • Prenatal identification is exceptional and post-natal diagnosis also proves challenging.
  • CASE PRESENTATION: We report one such case that was mistaken for other entities in both the prenatal and immediate post-natal period.
  • The working diagnoses were of a mediastinal teratoma or congenital cystic adenomatous malformation.
  • After excision, histopathological examination of the mass confirmed the diagnosis of cystic hygroma.
  • CONCLUSION: Despite the fact that isolated intrathoracic cystic hygroma is a rare entity, it needs to be considered in the differential diagnosis of foetal and neonatal mediastinal masses, particularly for juxtadiaphragmatic lesions.
  • Post-natal diagnosis may also be misleading as many mediastinal cystic masses have similar appearances on imaging.

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  • (PMID = 18673546.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2518156
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54. Li HZ, Gao Y, Zhao XL, Liu YX, Sun BC, Yang J, Yao Z: Effects of raf kinase inhibitor protein expression on metastasis and progression of human breast cancer. Mol Cancer Res; 2009 Jun;7(6):832-40
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  • Compared with the normal breast epithelia, benign breast epithelia, or in situ ductal carcinoma, the expression level of RKIP is decreased in invasive carcinoma and significantly reduced or lost in the metastasis lymph node matched to the invasive carcinoma.
  • Cell proliferation, soft-agar colony formation, in vitro adhesion assay, invasion, and migation assays were done to examine the malignant phenotypes of the transfected cells.
  • [MeSH-major] Breast Neoplasms / metabolism. Breast Neoplasms / pathology. Phosphatidylethanolamine Binding Protein / biosynthesis
  • [MeSH-minor] Analysis of Variance. Animals. Cell Adhesion / physiology. Cell Growth Processes / physiology. Cell Line, Tumor. Female. Humans. Immunohistochemistry. Lung Neoplasms / metabolism. Lung Neoplasms / secondary. Mice. Mice, Inbred BALB C. Neoplasm Invasiveness. Neoplasm Metastasis. Neovascularization, Pathologic / metabolism. Statistics, Nonparametric. Tissue Distribution


55. Nyman HT, Kristensen AT, Lee MH, Martinussen T, McEvoy FJ: Characterization of canine superficial tumors using gray-scale B mode, color flow mapping, and spectral doppler ultrasonography--a multivariate study. Vet Radiol Ultrasound; 2006 Mar-Apr;47(2):192-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The objectives of this study were to characterize the ultrasonographic patterns of superficial tumors and to evaluate whether ultrasound can help discriminate between benign and malignant tumors in dogs.
  • Size, echogenicity, tumor border definition, invasiveness, acoustic transmission, presence and distribution of vascular flow to and within the tumor, as well as perfusion indices were measured.
  • The tumors were classified as lipomas, benign tumors, atypical mammary tumors, and malignant tumors.
  • Multivariate statistics using discriminant analysis was used to determine which parameters may be used to predict the status of the tumor.
  • Tumor echogenicity, border shape, acoustic shadowing, total number of vessels to the tumor and the total flow amount are the parameters that in combination resulted in the lowest classification error (24%), meaning that on average three out of four tumors were correctly classified using these parameters.
  • The results of this study show that ultrasonography has an important role in the evaluation of canine superficial tumors, particularly in the evaluation of tissue homogeneity and tumor vascularity.
  • [MeSH-major] Dog Diseases / ultrasonography. Lipoma / veterinary. Soft Tissue Neoplasms / veterinary
  • [MeSH-minor] Animals. Dogs. Female. Male. Multivariate Analysis. Neoplasm Metastasis. Predictive Value of Tests. Pulsatile Flow. Regional Blood Flow. Ultrasonography, Doppler, Color / veterinary

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  • (PMID = 16553153.001).
  • [ISSN] 1058-8183
  • [Journal-full-title] Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
  • [ISO-abbreviation] Vet Radiol Ultrasound
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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56. Murphy A, Williams J: Posterior interosseous nerve palsy caused by lipoma: A case report. Can J Plast Surg; 2009;17(4):e42-4
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  • Lipomas are benign soft tissue neoplasms that occur commonly in subcutaneous tissue.

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  • (PMID = 21119834.001).
  • [ISSN] 1918-1507
  • [Journal-full-title] The Canadian journal of plastic surgery = Journal canadien de chirurgie plastique
  • [ISO-abbreviation] Can J Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2827290
  • [Keywords] NOTNLM ; Forearm / Lipoma / Posterior interosseous nerve palsy
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57. Ababneh K, Al-Khateeb T: Aggressive pregnancy tumor mimicking a malignant neoplasm: a case report. J Contemp Dent Pract; 2009;10(6):E072-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aggressive pregnancy tumor mimicking a malignant neoplasm: a case report.
  • AIM: The aim of this report is to present the management of an aggressive, highly proliferative pregnancy tumor with clinical and radiographic characteristics highly suggestive of a malignant neoplasm.
  • BACKGROUND: Pregnancy tumor is a benign hyperplastic gingival lesion occurring during pregnancy that is indistinguishable from a pyogenic granuloma arising in nonpregnant females, or in males.
  • A malignant process was suspected, and an incisional biopsy revealed a pregnancy tumor.
  • SUMMARY: Pregnancy tumor represents an important differential diagnosis of oral masses and can behave in a very aggressive fashion, mimicking a malignant tumor.
  • CLINICAL SIGNIFICANCE: This lesion should always be included in the differential diagnosis of soft tissue masses in a pregnant woman even if the lesion is clinically very aggressive.
  • [MeSH-major] Alveolar Bone Loss / etiology. Gingival Neoplasms / pathology. Gingival Overgrowth / pathology. Granuloma, Pyogenic / pathology. Pregnancy Complications, Neoplastic / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Mandible. Pregnancy. Treatment Outcome

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  • (PMID = 20020084.001).
  • [ISSN] 1526-3711
  • [Journal-full-title] The journal of contemporary dental practice
  • [ISO-abbreviation] J Contemp Dent Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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58. Halefoğlu AM: [The use of magnetic resonance imaging in the diagnosis of plantar fibromatosis: a case report]. Acta Orthop Traumatol Turc; 2005;39(2):176-9
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  • [Title] [The use of magnetic resonance imaging in the diagnosis of plantar fibromatosis: a case report].
  • Plantar fibromatosis is a benign but infiltrative neoplasm, presenting as a slow-growing nodular thickening most often within the central band of the plantar aponeurosis.
  • Magnetic resonance imaging is a noninvasive method for confirmation of the clinical diagnosis of plantar fibromatosis and also has an important role in planning surgical treatment by delineating the extent of the lesion.
  • [MeSH-major] Fibroma / diagnosis. Foot Diseases / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 15925942.001).
  • [ISSN] 1017-995X
  • [Journal-full-title] Acta orthopaedica et traumatologica turcica
  • [ISO-abbreviation] Acta Orthop Traumatol Turc
  • [Language] tur
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Turkey
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59. Thway K: Angiomatoid fibrous histiocytoma: a review with recent genetic findings. Arch Pathol Lab Med; 2008 Feb;132(2):273-7
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  • Angiomatoid fibrous histiocytoma is a neoplasm of intermediate biologic potential most often arising in the extremities of children and young adults.
  • Its rarity may lead to misdiagnosis as either a reactive lesion or a benign or higher-grade tumor.
  • The literature on angiomatoid fibrous histiocytoma is reviewed, particularly with regard to recent molecular genetic developments and differentiation, and its morphology, immunohistochemistry, and differential diagnosis are summarized.
  • [MeSH-major] Histiocytoma, Malignant Fibrous / genetics. Soft Tissue Neoplasms / genetics. Translocation, Genetic / genetics
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Chromosomes, Human, Pair 12. Chromosomes, Human, Pair 16. Chromosomes, Human, Pair 22. Desmin / metabolism. Humans. Immunohistochemistry

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  • (PMID = 18251589.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Desmin
  • [Number-of-references] 27
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60. Canavese F, Soo BC, Chia SK, Krajbich JI: Surgical outcome in patients treated for hemangioma during infancy, childhood, and adolescence: a retrospective review of 44 consecutive patients. J Pediatr Orthop; 2008 Apr-May;28(3):381-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Hemangiomas are the most common tumors in infancy and childhood and account for 7% of benign soft tissue tumors.
  • Diagnosis is usually made in infancy or childhood.
  • There are only a few reports on the surgical treatment of these lesions, likely because the lesions are quite vascular, have a tendency to infiltrate into the muscle and other tissues, and the recurrence rate is quite high.
  • Asymptomatic lesions should be monitored to confirm the diagnosis and to look for signs of progression.
  • A marginal resection may be used to treat most superficial soft tissue tumors.
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Child. Child, Preschool. Female. Hemangioma, Cavernous / diagnosis. Hemangioma, Cavernous / surgery. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / epidemiology. Retrospective Studies. Treatment Outcome

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  • (PMID = 18362808.001).
  • [ISSN] 0271-6798
  • [Journal-full-title] Journal of pediatric orthopedics
  • [ISO-abbreviation] J Pediatr Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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61. Baba T, Kariya M, Higuchi T, Mandai M, Matsumura N, Kondoh E, Miyanishi M, Fukuhara K, Takakura K, Fujii S: Neuropilin-1 promotes unlimited growth of ovarian cancer by evading contact inhibition. Gynecol Oncol; 2007 Jun;105(3):703-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • While there are some reports of NRP-1 expression in ovarian neoplasm, those results differ in pattern of its expression and its role in ovarian cancer is still unclear.
  • METHODS: NRP-1 expression was analyzed with eighty-seven ovarian tissue samples by immunohistochemistry and four ovarian cell lines by quantitative RT-PCR and Western blotting.
  • To detect its molecular role in ovarian cancer, WST-1 assay, invasion assay and soft agar assay were performed with or without NRP-1 suppression by the introduction of short hairpin RNAs.
  • RESULTS: NRP-1 expression was found to be enhanced in ovarian cancer compared with ovarian surface epithelium (OSE), benign adenoma and tumors of low malignant potential.
  • Suppression of NRP-1 also decreased cell growth in soft agar and invasion to the extracellular matrix in vitro.
  • [MeSH-major] Cell Communication / physiology. Contact Inhibition / physiology. Neuropilin-1 / physiology. Ovarian Neoplasms / metabolism
  • [MeSH-minor] Cell Adhesion / physiology. Cell Count. Cell Growth Processes / physiology. Cell Line, Tumor. Female. Humans. Immunohistochemistry. Middle Aged. Neoplasm Invasiveness. RNA, Small Interfering / genetics

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  • (PMID = 17376520.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Small Interfering; 144713-63-3 / Neuropilin-1
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62. de Saint Aubain Somerhausen N, Coindre JM, Debiec-Rychter M, Delplace J, Sciot R: Lipoblastoma in adolescents and young adults: report of six cases with FISH analysis. Histopathology; 2008 Feb;52(3):294-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIMS: Lipoblastoma is a rare benign adipocytic neoplasm that occurs primarily in infancy and early childhood.
  • Histologically, there is some morphological overlap with atypical lipomatous tumour and myxoid liposarcoma and the age at presentation is often regarded as a major diagnostic criterion.
  • Three tumours were composed predominantly of mature adipocytes and the three other cases showed an immature appearance, with a prominent myxoid matrix.
  • Fluorescence in situ hybridization (FISH) demonstrated rearrangements of the PLAG1 region in two cases and polysomy for chromosome 8 in three other cases.
  • CONCLUSIONS: Lipoblastoma occurs rarely in young adults and should enter into the differential diagnosis of 'atypical' fatty tumours in adults.
  • [MeSH-major] DNA, Neoplasm / analysis. In Situ Hybridization, Fluorescence. Lipoma / genetics. Lipoma / pathology. Soft Tissue Neoplasms / genetics. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adipocytes / pathology. Adolescent. Adult. Chromosome Aberrations. Disease-Free Survival. Female. Humans. Male. Neoplasm Recurrence, Local

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  • (PMID = 18269579.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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63. Dim DC, Nugent SL, Peng HQ: Ganglioneuroma presenting as a paraesophageal mass lesion diagnosed by endoscopic ultrasound-guided fine needle aspiration cytology: a case report. Acta Cytol; 2010 May-Jun;54(3):321-4
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  • BACKGROUND: Endoscopic ultrasound-guided fine needle aspiration is a well-established modality in detection and diagnosis of mediastinal lesions.
  • Ganglioneuroma is a benign, rare, soft tissue neoplasm arising from sympathetic ganglion cells, and complete surgical resection is considered to be curative.
  • Ganglioneuroma in a surgical specimen is a straightforward diagnosis; however, due to the infrequent occurrence of this entity, diagnosis by fine needle aspiration is more challenging.
  • [MeSH-major] Ganglioneuroma / diagnosis. Mediastinal Neoplasms / pathology. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Diagnosis, Differential. Endosonography. Esophagus / pathology. Humans. Male. S100 Proteins / metabolism

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  • (PMID = 20518419.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins
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64. Monson E, Vancourt R, Dawson J: Myxoinflammatory fibroblastic sarcoma: a case report and review of the literature. J Foot Ankle Surg; 2010 Jan-Feb;49(1):86.e1-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The majority of soft tissue masses seen in the lower extremity are benign tumors caused by degenerative, reactive, or inflammatory processes.
  • We present a case of a myxoinflammatory fibroblastic sarcoma of the leg and review the literature on this topic.
  • This is a rare tumor that predominately involves the distal extremities.
  • It often presents as a painless mass within the subcutaneous tissue and can easily be confused with benign lesions.
  • A high rate of local recurrence means patients must be followed up closely after resection of the tumor.
  • [MeSH-major] Fibrosarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Amputation. Humans. Leg. Male. Middle Aged. Muscle, Skeletal / pathology. Neoplasm Invasiveness. Neoplasm Recurrence, Local / surgery. Postoperative Complications. Surgical Flaps

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  • [Copyright] Copyright 2010 American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20123295.001).
  • [ISSN] 1542-2224
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 8
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65. Wu CW, Chi HP, Chiang FY, Hsu YC, Chan LP, Kuo WR: Giant lipoma arising from deep lobe of the parotid gland. World J Surg Oncol; 2006;4:28
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  • BACKGROUND: Lipomas are common benign soft tissue neoplasms but they are found very rarely in the deep lobe of parotid gland.

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  • (PMID = 16740172.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1481629
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66. Klenke FM, Merkle T, Fellenberg J, Abdollahi A, Huber PE, Gebhard MM, Ewerbeck V, Sckell A: A novel model for the investigation of orthotopically growing primary and secondary bone tumours using intravital microscopy. Lab Anim; 2005 Oct;39(4):377-83
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  • Although up to 85% of the most frequently occurring malignant solid tumours, such as lung and prostate carcinomas, metastasize into the bone, and despite the knowledge that a tumour's course may be altered by its surrounding tissue, there is no adequate experimental model available enabling the investigation of orthotopically grown bone tumours in vivo.
  • Intravital microscopy is an internationally accepted experimental method, used in various acute and chronic animal models, that enables qualitative and quantitative analysis of the angiogenesis, microcirculation, growth behaviour, etc. of various benign and malignant tissues.
  • Additionally, tissue samples can be taken after termination of the in vivo experiments for further ex vivo investigation (histology, immunohistochemistry, molecular biology, etc.
  • Severe combined immunodeficient mice were fitted with a cranial window preparation where the calvaria served as the site for orthotopic implantation of the solid human tumours Saos-2 osteosarcoma (primary) and A 549 lung carcinoma and PC-3 prostate carcinoma (secondary).
  • Histological assessment confirmed the data obtained in vivo, showing typical tumour growth with infiltration of the surrounding osseous and soft tissues.
  • This novel model serves as a valuable tool in understanding the biology of primary and secondary bone tumours in physiological and pathophysiological situations, with implications for the most areas of tumour therapy such as chemotherapy, radiation and antiangiogenesis.
  • [MeSH-major] Bone Neoplasms / pathology. Osteosarcoma / pathology
  • [MeSH-minor] Animals. Lung Neoplasms / pathology. Male. Mice. Mice, SCID. Microscopy, Fluorescence. Microscopy, Video. Neoplasm Transplantation. Neovascularization, Pathologic / pathology. Prostatic Neoplasms / pathology

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  • (PMID = 16197704.001).
  • [ISSN] 0023-6772
  • [Journal-full-title] Laboratory animals
  • [ISO-abbreviation] Lab. Anim.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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67. Nigri G, Dente M, Valabrega S, Beccaria G, Aurello P, D'Angelo F, Di Marzo F, Ramacciato G: Giant inframuscular lipoma disclosed 14 years after a blunt trauma: a case report. J Med Case Rep; 2008;2:318
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  • INTRODUCTION: Lipoma is the most frequent benign tumor of the soft tissue.
  • Although the diagnosis is mostly clinical, imaging tools are useful to confirm the adipose nature of the lesion and to define its anatomic border.
  • Sometimes, lipomas may be the result of a previous trauma, such as in this patient.
  • We herein present an exceptional case of a giant post-traumatic lipoma which caused a painful compression on the right sciatic nerve.

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  • [Cites] Br J Dermatol. 2007 Jul;157(1):92-9 [17553055.001]
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  • (PMID = 18826615.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2569952
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68. Ui M, Ogawa K: Subdeltoid lipoma: a case with symptoms mimicking glenohumeral instability and subacromial impingement. Orthopedics; 2010 Jun;33(6):443
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  • Lipoma is the most frequently occurring benign soft tissue tumor in the shoulder and the axillary region in middle-aged and older persons, yet few such lipoma cases have been associated with clinical symptoms.
  • A 38-year-old right-handed man presented with an enlarged feeling and a painful back-and-forth popping in his left shoulder.
  • Magnetic resonance imaging showed a homogenous tumor in the subdeltoid that was isointense relative to the subcutaneous fat and fluid collection in the hypertrophic subacromial bursa.
  • As the tumor was considered from the clinical and imaging findings to be attributable to all clinical symptoms, it was resected en bloc with a satisfactory result.
  • Histopathologically, the tumor showed typical features of a simple lipoma.
  • To our knowledge, the present case is the first of a subdeltoid intermuscular lipoma of which mechanism developing symptoms was preoperatively surmised from imaging.
  • [MeSH-major] Lipoma / diagnosis. Muscle Neoplasms / diagnosis. Shoulder Dislocation / diagnosis. Shoulder Impingement Syndrome / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Shoulder

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  • [Copyright] Copyright 2010, SLACK Incorporated.
  • (PMID = 20806760.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Erdas E, Licheri S, Pinna G, Gerosa C, Ragazzo G: [Elastofibroma dorsi: case report and review of the literature]. G Chir; 2006 Oct;27(10):372-6
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  • [Transliterated title] L'elastofibroma dorsi: descrizione di un caso clinico e analisi della letteratura.
  • Elastofibroma dorsi (ED) is a rare, benign, often bilateral lesion of the thoracic wall, occurring most commonly in the infra-scapular region beneath the muscular tissue, generally found in elderly women.
  • Whether ED should be considered as a true neoplasm or merely as a reaction of connective tissue to repetitive minor trauma is still debated.
  • ED has characteristic features but a low incidence and is therefore not always easily distinguished from other benign and malignant soft-tissue tumors.
  • Inappropriate treatment may thus be administrated in the absence of a definitive diagnosis.
  • We report a case of a 51-year-old woman who presented with a right infra-scapular swelling associated with pain and a clicking sensation during selective arm movements.
  • Upon clinical and ultrasound examination, the lesion had the appearance of a deep dorsal lipoma, but intraoperative findings were suggestive of a sarcoma originating from the periosteum of ribs.
  • Nonetheless, marginal surgical excision was performed and the tumor was histologically diagnosed as ED.
  • In conclusion, ED should be always considered in the differential diagnosis of tumors deeply located in the infra-scapular area, especially in elderly women.
  • As it is a benign lesion, surgical treatment is recommended only in symptomatic cases or if a large swelling is present.
  • [MeSH-major] Elastic Tissue / pathology. Fibroma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Scapula. Treatment Outcome

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  • (PMID = 17147850.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 28
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70. Chiang ER, Chen TH: Multiple glomus tumors in gastrocnemius muscle: a case report. Arch Orthop Trauma Surg; 2008 Jan;128(1):29-31
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  • Glomus tumors are rare benign tumors that account 1-5% of soft tissue tumors of the hand.
  • We describe an unusual case of recurrent glomus tumor located in lower leg.
  • The final diagnosis was established by pathologic examination of the surgical resection specimen.
  • [MeSH-major] Glomus Tumor / diagnosis. Muscle Neoplasms / diagnosis. Muscle, Skeletal. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 17624538.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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71. Wilde F, Neid M, Schulz T, Sterker I, Hemprich A, Frerich B: [Hemangiopericytoma (extrapleural solitary fibrous tumour). Exemplified and discussed on the basis of two cases]. Mund Kiefer Gesichtschir; 2005 Nov;9(6):404-8
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  • [Title] [Hemangiopericytoma (extrapleural solitary fibrous tumour). Exemplified and discussed on the basis of two cases].
  • [Transliterated title] Hämangioperizytom (extrapleuraler solitärer fibröser Tumor). Dargestellt und diskutiert anhand zweier Patientenbeispiele.
  • It is a very uncommon potentially malignant vascular tumour which can occur at every site of the body.
  • The diagnosis of "hemangiopericytoma" is now only determined if a constant histological picture of hemangiopericytoma is present.
  • The tumour can lead to lymphogenous or hematogenous metastasis.
  • CASE REPORTS: Patient 1: 60 years, female; diagnosis: malignant suboccipital hemangiopericytoma; size: 4.9 x 4.5 x 4.2 cm; pT1bNXMX L0 V0 Pn0; stage IA; grading G1; R0.Patient 2: 38 years, male; diagnosis: benign hemangiopericytoma infraorbital left; size 1.5 x 1.5 x 1.5 cm.
  • The consistency ranges from soft to dense, and the color is greyish-blue.
  • The slow and painless growth carries the danger of a clinically wrong diagnosis and thus delayed therapy.
  • The histological diagnosis of hemangiopericytoma is determined by biopsy.
  • The therapy of choice is the complete tumour-resection with a safety margin of 1 cm.
  • [MeSH-major] Eyelid Neoplasms / diagnosis. Head and Neck Neoplasms / diagnosis. Hemangiopericytoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery. Orbit / pathology. Orbital Neoplasms / diagnosis. Orbital Neoplasms / pathology. Orbital Neoplasms / surgery. Reoperation. Tomography, X-Ray Computed

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  • (PMID = 16220316.001).
  • [ISSN] 1432-9417
  • [Journal-full-title] Mund-, Kiefer- und Gesichtschirurgie : MKG
  • [ISO-abbreviation] Mund Kiefer Gesichtschir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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72. Jani DR, Chawda J, Sundaragiri SK, Parmar G: Mucocele--a study of 36 cases. Indian J Dent Res; 2010 Jul-Sep;21(3):337-40
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  • BACKGROUND: Mucocele is one of the most common benign soft tissue tumor present in the oral cavity.
  • The clinical data were recorded and histopathologic diagnosis was made.
  • RESULTS: A diagnosis of mucocele was established in 36 cases with male-to-female ratio of 1.77:1.

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  • (PMID = 20930340.001).
  • [ISSN] 1998-3603
  • [Journal-full-title] Indian journal of dental research : official publication of Indian Society for Dental Research
  • [ISO-abbreviation] Indian J Dent Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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73. Bestic JM, Peterson JJ, Bancroft LW: Pediatric FDG PET/CT: Physiologic uptake, normal variants, and benign conditions [corrected]. Radiographics; 2009 Sep-Oct;29(5):1487-500
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  • [Title] Pediatric FDG PET/CT: Physiologic uptake, normal variants, and benign conditions [corrected].
  • Standard imaging evaluation of bone and soft-tissue sarcomas typically consists of conventional radiography, magnetic resonance (MR) imaging, computed tomography (CT), and bone scintigraphy.
  • It represents a noninvasive means of estimating histologic tumor grade and can be used to detect progression or regression of disease prior to anatomic imaging.
  • [MeSH-major] Bone Neoplasms / radionuclide imaging. Bone Neoplasms / therapy. Fluorodeoxyglucose F18. Positron-Emission Tomography / methods. Sarcoma, Ewing / radionuclide imaging. Sarcoma, Ewing / therapy
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Neoplasm Staging. Prognosis. Radiopharmaceuticals. Treatment Outcome. Young Adult

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  • [Copyright] (c) RSNA, 2009.
  • [CommentIn] Radiographics. 2009 Sep-Oct;29(5):1500-1; discussion 1501 [19764110.001]
  • [ErratumIn] Radiographics. 2010 Jan-Feb;30(1):301
  • (PMID = 19755607.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 21
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74. Woo EK, Lim TK, Tan SH: Neurothekeomas of the upper limb--case series and clinicopathological review. Hand Surg; 2005;10(2-3):311-7
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  • Neurothekeomas are rare, benign soft tissue tumours that are considered to be of nerve sheath origin.
  • There was a remarkably high tumour recurrence rate.
  • The factors contributing to this outcome were studied and a clinicopathological review was performed.
  • [MeSH-major] Neoplasm Recurrence, Local / pathology. Neurothekeoma / pathology. Neurothekeoma / surgery. Upper Extremity

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  • (PMID = 16568535.001).
  • [ISSN] 0218-8104
  • [Journal-full-title] Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand
  • [ISO-abbreviation] Hand Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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75. Tytherleigh MG, Birtle AJ, Cohen CE, Glynne-Jones R, Livingstone J, Gilbert J: Combined surgery and chemoradiation as a treatment for the Buschke-Löwenstein tumour. Surgeon; 2006 Dec;4(6):378-83
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  • [Title] Combined surgery and chemoradiation as a treatment for the Buschke-Löwenstein tumour.
  • BACKGROUND: The Buschke-Löwenstein tumour (BLT) or giant condyloma acuminata is a rare disease which affects the anogenital region.
  • Although histologically benign, it behaves in a malignant fashion, infiltrating the surrounding tissues.
  • The morbidity and mortality from this tumour is high, as is the risk of recurrence following treatment.
  • It lies on the continuum between the benign condylomata acuminata and squamous cell carcinoma.
  • CONCLUSION: Pre-operative chemoradiation has proved to be useful in management for histologically proven benign BLT
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Condylomata Acuminata / therapy. Neoadjuvant Therapy. Perineum / pathology. Perineum / surgery. Soft Tissue Neoplasms / therapy
  • [MeSH-minor] Abdominal Neoplasms / secondary. Abdominal Neoplasms / therapy. Adult. Anus Neoplasms / secondary. Anus Neoplasms / therapy. Carcinoma in Situ / pathology. Carcinoma in Situ / therapy. Carcinoma, Squamous Cell / therapy. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Fatal Outcome. Fluorouracil / administration & dosage. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Radiotherapy, Adjuvant. Rectal Neoplasms / secondary. Rectal Neoplasms / therapy

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  • (PMID = 17152203.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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76. Ramirez RN, Otsuka NY, Apel DM, Bowen RE: Desmoid tumor in the pediatric population: a report of two cases. J Pediatr Orthop B; 2009 May;18(3):141-4
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  • [Title] Desmoid tumor in the pediatric population: a report of two cases.
  • Desmoid tumors are benign tumors that cause considerable morbidity and are prone to recurrence.
  • They tend to extensively infiltrate surrounding tissues, complicating the treatment.
  • We present the report of two cases of desmoid tumor in the pediatric population.
  • The first patient had tumor that necessitated removal of most of the anterior compartment of his leg.
  • The tumor in the second case was intimately involved with neurovascular structures and, therefore adjuvant treatment including chemotherapy and repeat surgery was necessary.
  • [MeSH-major] Fibromatosis, Aggressive / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Child. Combined Modality Therapy. Humans. Infant. Leg / surgery. Male. Neoplasm Recurrence, Local. Tendon Transfer. Treatment Outcome

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  • (PMID = 19322113.001).
  • [ISSN] 1473-5865
  • [Journal-full-title] Journal of pediatric orthopedics. Part B
  • [ISO-abbreviation] J Pediatr Orthop B
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. D'Alessandro V, Parracino T, Stranieri A, Greco A, De Cata A, Sperandeo M, Mazzoccoli G, Maiello E, Vendemiale G: Computed-tomographic-guided biopsy of thoracic nodules: a revision of 583 lesions. Clin Ter; 2007 Nov-Dec;158(6):509-13
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  • OBJECTIVES: In pulmonary lesions, when bronchial or trans-bronchial biopsy is negative, thoracic Fine-Needle Aspiration Biopsy (FNAB) allows to obtain a cytological or histological diagnosis.
  • MATERIALS AND METHODS: Between May 1995 and September 2005, 583 patients (453 males, 133 females), with thoracic lesions, without evident intrabronchial neoplasm, underwent CT-guided FNAB of thoracic nodules.
  • FNAB was performed with 19-20-21 gauge needles, disposable soft tissue, automatic aspiration biopsy Menghini set, 10-15 cm long.
  • There were 72 benign lesions (16 neoplasms) and 491 cancers (456 primary, 35 metastasis).
  • [MeSH-major] Biopsy, Fine-Needle / methods. Lung Neoplasms / diagnosis. Solitary Pulmonary Nodule / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chest Tubes. Diagnosis, Differential. Female. Hemoptysis / etiology. Humans. Lung Diseases / diagnosis. Male. Middle Aged. Pneumothorax / etiology. Pneumothorax / therapy. Predictive Value of Tests. Sensitivity and Specificity

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  • (PMID = 18265716.001).
  • [ISSN] 0009-9074
  • [Journal-full-title] La Clinica terapeutica
  • [ISO-abbreviation] Clin Ter
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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78. Liegl B, Hornick JL, Fletcher CD: Primary cutaneous PEComa: distinctive clear cell lesions of skin. Am J Surg Pathol; 2008 Apr;32(4):608-14
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  • PEComas arising in somatic soft tissue or skin are rare.
  • Tumor size ranged from 0.7 to 2 cm (median size, 1.5 cm).
  • Tumor cells had clear, palely eosinophilic or granular cytoplasm.
  • Multinucleate tumor giant cells were observed in 3 cases.
  • In cases where HMB-45 was positive in fewer than 5% of tumor cells (5/10), microphthalmia transcription factor was positive in the majority of the tumor cell nuclei.
  • The other muscle markers (caldesmon, calponin) and also pan-keratin and epithelial membrane antigen were negative.
  • Primary cutaneous PEComas are rare and thus far apparently benign cutaneous tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Actins / analysis. Adolescent. Adult. Aged. Aged, 80 and over. Antigens, Neoplasm / analysis. Calcium-Binding Proteins / analysis. Calmodulin-Binding Proteins / analysis. Dermis / pathology. Desmin / analysis. Diagnosis, Differential. Female. Giant Cells / pathology. Humans. Immunohistochemistry. Keratins / analysis. MART-1 Antigen. Male. Melanoma-Specific Antigens. Microfilament Proteins / analysis. Microphthalmia-Associated Transcription Factor / analysis. Middle Aged. Mitotic Index. Mucin-1 / analysis. Neoplasm Invasiveness. Neoplasm Proteins / analysis. Subcutaneous Fat / pathology

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  • [CommentIn] Am J Dermatopathol. 2016 Feb;38(2):165-6 [26825164.001]
  • (PMID = 18277881.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Calcium-Binding Proteins; 0 / Calmodulin-Binding Proteins; 0 / Desmin; 0 / MART-1 Antigen; 0 / MITF protein, human; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Microfilament Proteins; 0 / Microphthalmia-Associated Transcription Factor; 0 / Mucin-1; 0 / Neoplasm Proteins; 0 / calponin; 68238-35-7 / Keratins
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79. González-Bugatto F, Añón-Requena MJ, López-Guerrero MA, Báez-Perea JM, Bartha JL, Hervías-Vivancos B: Vulvar leiomyosarcoma in Bartholin's gland area: a case report and literature review. Arch Gynecol Obstet; 2009 Feb;279(2):171-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Malignant tumours of the vulvar soft tissue are very uncommon.
  • When localized in the Bartholin's gland area these tumours can be mistaken for benign lesions, leading to a delayed diagnosis.
  • Pathologist report informed of a 6 cm diameter leiomyosarcoma of the vulva with compromised resection margins; extension studies did not suggest any additional lesions and radical hemivulvectomy with ipsilateral inguinal lymphadenectomy was performed.
  • [MeSH-major] Bartholin's Glands / pathology. Leiomyosarcoma / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Chemotherapy, Adjuvant. Diagnosis, Differential. Female. Groin. Humans. Lymph Node Excision. Middle Aged. Neoplasm Recurrence, Local / surgery. Radiotherapy, Adjuvant


80. Nakashima K, Yamada N, Yoshida Y, Yamamoto O: Solitary sclerotic neurofibroma of the skin. Am J Dermatopathol; 2008 Jun;30(3):278-80
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  • Solitary neurofibroma of the skin is a benign soft tissue tumor.
  • Clinically, it is a flesh-colored, slow-growing, soft tumor and sometimes shows diverse histological patterns.
  • Our findings suggest that mast cells may have played a role in the formation of the sclerotic regions of the current tumor.
  • [MeSH-major] Neurofibroma / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Aged. Collagen / metabolism. Dermis / pathology. Female. Humans. Mast Cells / pathology. Sclerosis / metabolism. Sclerosis / pathology. Subcutaneous Tissue / pathology

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  • (PMID = 18496433.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-34-5 / Collagen
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81. Chiou HJ, Chou YH, Chiu SY, Wang HK, Chen WM, Chen TH, Chang CY: Differentiation of benign and malignant superficial soft-tissue masses using grayscale and color doppler ultrasonography. J Chin Med Assoc; 2009 Jun;72(6):307-15
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  • [Title] Differentiation of benign and malignant superficial soft-tissue masses using grayscale and color doppler ultrasonography.
  • BACKGROUND: This study was performed to evaluate the usefulness of high-resolution grayscale and color Doppler ultrasound to distinguish benign from malignant soft-tissue masses on the basis of ultrasonographic patterns.
  • Each lesion was examined by grayscale and color Doppler ultrasonography to assess its echogenicity, margin, shape, composition, acoustic transmission, size and other patterns.
  • RESULTS: There were a total of 693 benign and 125 malignant masses.
  • Five malignant and 14 benign histologies (including 6 types with inflammation-related, hematoma or pseudoaneurysm) occurred that had more than 10 subjects with each histology.
  • Eight benign histopathologies included cysts, neoplasms, vascular and miscellaneous.
  • There were significant differences (p < 0.05) between the benign and malignant soft-tissue tumors in terms of parameters including tumor margin, shape and size.
  • Benign lesions did not have infiltrated margins or a scalloped shape and malignant tumors tended to be large.
  • However, there was no significant difference (p > 0.05) between the benign and malignant soft-tissue tumors in terms of echogenicity, composition and color Doppler features.
  • CONCLUSION: Ultrasonography with color Doppler imaging is a good modality for characterizing most soft-tissue masses, and tumor size > 5 cm and having infiltrated margin highly suggests malignancy.
  • [MeSH-major] Soft Tissue Neoplasms / ultrasonography. Ultrasonography, Doppler, Color / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Epidermal Cyst / pathology. Epidermal Cyst / ultrasonography. Female. Giant Cell Tumors / pathology. Giant Cell Tumors / ultrasonography. Hemangioma / pathology. Hemangioma / ultrasonography. Humans. Infant. Liposarcoma / pathology. Liposarcoma / ultrasonography. Male. Middle Aged. Neoplasm Metastasis. Neurilemmoma / pathology. Neurilemmoma / ultrasonography. Retrospective Studies

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  • (PMID = 19541566.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China (Republic : 1949- )
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82. Miller DV, Wang H, Wang H, Fealey ME, Tazelaar HD: Beta-catenin mutations do not contribute to cardiac fibroma pathogenesis. Pediatr Dev Pathol; 2008 Jul-Aug;11(4):291-4
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  • Cardiac fibromas are the 2nd most common benign cardiac tumor occurring in children and bear a striking morphologic resemblance to soft tissue or desmoid fibromatosis.
  • Since activating mutations in beta-catenin are common in desmoid fibromatosis as well as other spindle cell proliferations, the aim of our study was to determine if such mutations could be identified in cardiac fibroma.
  • Nine cardiac fibromas from patients with surgical resection were examined for beta-catenin mutations by immunoperoxidase staining for beta-catenin protein and DNA sequencing of a region in exon 3 of the beta-catenin gene, where relatively conserved mutations have been described in desmoid fibromatosis.
  • We conclude that despite their morphologic similarity, cardiac fibroma and desmoid fibromatosis do not share this common molecular pathway of neoplastic growth.
  • [MeSH-major] Fibroma / genetics. Genetic Predisposition to Disease. Heart Neoplasms / genetics. beta Catenin / genetics
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Child. Child, Preschool. DNA Mutational Analysis. DNA, Neoplasm / analysis. Female. Humans. Immunoenzyme Techniques. Infant. Male. Mutation

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  • (PMID = 18078366.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / beta Catenin
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83. Datir A, James SL, Ali K, Lee J, Ahmad M, Saifuddin A: MRI of soft-tissue masses: the relationship between lesion size, depth, and diagnosis. Clin Radiol; 2008 Apr;63(4):373-8; discussion 379-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MRI of soft-tissue masses: the relationship between lesion size, depth, and diagnosis.
  • AIMS: To identify the relationship between depth and size of soft-tissue mass lesions relative to histological diagnosis in a range of malignant neoplastic, benign neoplastic, and non-neoplastic conditions on magnetic resonance imaging (MRI).
  • METHOD: The MRI findings of 571 consecutive patients referred to a supra-regional orthopaedic oncology unit with a suspected soft-tissue neoplasm were reviewed and included in the study.
  • The patient age, histological diagnosis, lesion size, anatomical location, and lesion depth (superficial or deep to fascia) were recorded.
  • The mean age was 54.1 years for malignant neoplastic lesions compared with 40.1 years for benign neoplastic and 45.4 years for non-neoplastic conditions.
  • There was a significant age difference when malignant lesions were compared with benign neoplastic and non-neoplastic lesions (p<0.001).
  • No significant relationship was present between lesion depth (480 deep, 91 superficial) and diagnosis (288 malignant neoplastic, 197 benign neoplastic and 86 non-neoplastic lesions).
  • However, a significant relationship was identified between lesion size and diagnosis (p<0.001).
  • Furthermore, a significant relationship was identified when lesion size greater than 5 cm, lesion depth, and diagnosis were analysed.
  • CONCLUSION: Current guidelines suggest the most important variables for assessing risk of malignancy in a soft-tissue lesion include size, depth in relation to the fascia, increasing size, and pain.
  • [MeSH-major] Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Abscess / diagnosis. Abscess / pathology. Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Fibroma / diagnosis. Fibroma / pathology. Ganglion Cysts / diagnosis. Ganglion Cysts / pathology. Hemangioma / diagnosis. Hemangioma / pathology. Histiocytoma, Malignant Fibrous / diagnosis. Histiocytoma, Malignant Fibrous / pathology. Humans. Lipoma / diagnosis. Lipoma / pathology. Liposarcoma / diagnosis. Liposarcoma / pathology. Magnetic Resonance Imaging. Male. Middle Aged. Myositis Ossificans / diagnosis. Myositis Ossificans / pathology. Prospective Studies. Risk Factors. Sarcoma, Synovial / diagnosis. Sarcoma, Synovial / pathology

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  • (PMID = 18325355.001).
  • [ISSN] 0009-9260
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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84. Pellegrino M, Vadrucci S, Tinelli A: [Angiomyofibroblastoma of the vulva: a rare but distinct entity. Case report and literature review]. Pathologica; 2007 Dec;99(6):438-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Angiomyofibroblastoma is a benign vulvar tumour involving soft tissue that is characterized by alternating hypocellular and hypercellular areas of spindle stromal cells, admixed and aggregated around blood vessels.
  • It is important to recognize this entity as it shows benign behaviour with respect to other mesenchymal tumours of the vagina, which have a more aggressive behaviour.
  • [MeSH-major] Angiofibroma / pathology. Angiomyoma / pathology. Hemangioblastoma / pathology. Neoplasms, Second Primary / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, CD34 / analysis. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor. Breast Neoplasms / drug therapy. Breast Neoplasms / surgery. Combined Modality Therapy. Female. Humans. Lymphoma, Large B-Cell, Diffuse / drug therapy. Lymphoma, Large B-Cell, Diffuse / surgery. Neoplasm Proteins / analysis. Receptors, Estrogen / analysis

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  • (PMID = 18416337.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Receptors, Estrogen
  • [Number-of-references] 7
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85. Rubin AI, Yassaee M, Johnson W, Elenitsas R, Zaladonis J Jr, Seykora JT: Multiple cutaneous sclerosing perineuriomas: an extensive presentation with involvement of the bilateral upper extremities. J Cutan Pathol; 2009 Oct;36 Suppl 1:60-5
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  • A perineurioma is a benign peripheral nerve sheath neoplasm thought to be derived from cells of the perineurium, the cellular sheathing of peripheral nerve fascicles.
  • The histological, immunohistochemical (positive for epithelial membrane antigen, collagen type IV, laminin and vimentin but not S-100 protein) and ultrastructural features of a perineurioma form the basis for diagnosis.
  • Two types of perineuriomas are recognized, intraneural and soft tissue (extraneural) forms.
  • Sclerosing perineurioma is considered a variant of the soft tissue perineurioma.
  • [MeSH-major] Neoplasms, Multiple Primary / pathology. Nerve Sheath Neoplasms / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19187114.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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86. Edwards PC, Fantasia JE, Saini T, Rosenberg TJ, Sachs SA, Ruggiero S: Clinically aggressive central giant cell granulomas in two patients with neurofibromatosis 1. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Dec;102(6):765-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Neurofibromatosis 1 (NF1) is an autosomal dominantly inherited disorder caused by a spectrum of mutations affecting the Nf1 gene.
  • Affected patients develop benign and malignant tumors at an increased frequency.
  • Clinical findings include multiple cutaneous café-au-lait pigmentations, neurofibromas, axillary freckling, optic gliomas, benign iris hamartomas (Lisch nodules), scoliosis, and poorly defined soft tissue lesions of the skeleton.
  • Alternatively, the CGCG in NF1 patients could represent a true neoplasm, resulting from additional, as of yet unidentified, genetic alterations to Nf1-haploinsufficient bone.


87. Bobbio A, Mazzeo A, Carbognani P, Rusca M: An unusual case of calcifying fibrous pseudotumour of the cervicothoracic junction. Eur J Cardiothorac Surg; 2008 Nov;34(5):1123-5
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  • Calcifying fibrous pseudotumour is a rare benign tumour of soft tissue origin, occasionally encountered in the thoracic cavity; surgical resection is considered the treatment of choice.
  • Herein we present the case of a young woman who presented with a calcifying fibrous pseudotumour located in the left cervicothoracic junction.
  • At surgery the tumour was found to circumferentially entrap the left subclavian artery and its removal involved segmental artery resection and reconstruction by autologous saphenous vein graft.

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  • (PMID = 18755598.001).
  • [ISSN] 1873-734X
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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88. Rohilla S, Yadav RK, Dhaulakhandi DB: Lipoma of Guyon's canal causing ulnar neuropathy. J Orthop Traumatol; 2009 Jun;10(2):101-3
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  • Lipoma is a benign soft tissue tumor which rarely causes neuropathy.

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  • [Cites] Ann Fr Anesth Reanim. 2008 Jan;27(1):114-5 [18164175.001]
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  • (PMID = 19468684.001).
  • [ISSN] 1590-9921
  • [Journal-full-title] Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology
  • [ISO-abbreviation] J Orthop Traumatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2688595
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89. Athwal GS, Bueno RA, Bansal M, Mintz DN, Athanasian EA: Intra-articular fibroma of tendon sheath involving the scapholunate and radiocarpal joints. Skeletal Radiol; 2006 Aug;35(8):599-602
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Fibroma of tendon sheath is an uncommon benign soft tissue tumor with a predilection for the hand.
  • Magnetic resonance imaging demonstrated a heterogeneous and lobulated mass with nonspecific signal characteristics closely associated with the scapholunate interval and the volar wrist soft tissues.
  • The tumor is discussed and the relevant literature is reviewed.
  • [MeSH-major] Fibroma / pathology. Soft Tissue Neoplasms / pathology. Wrist Joint / pathology

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  • (PMID = 16283174.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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90. Mourad OM, Andrade FM, Abrahão P, Monnerat A, Judice LF: Asymptomatic giant mediastinal mass: a rare case of thymolipoma. J Bras Pneumol; 2009 Oct;35(10):1049-52
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  • Thymolipoma is a very rare benign neoplasm of the thymus.
  • We present the case of a 42-year-old male with a massive mediastinal tumor discovered on a chest X-ray after a motorcycle accident.
  • Chest CT scans revealed a lipomatous mass containing areas of soft tissue density.
  • The patient was submitted to median sternotomy expanded to left anterolateral thoracotomy, resulting in the complete excision of the tumor.
  • The pathological diagnosis was thymolipoma.
  • Thymolipoma usually attains enormous dimensions by the time of diagnosis, and the occasional symptoms are related to compression of adjacent structures.
  • [MeSH-major] Lipoma / diagnosis. Mediastinal Neoplasms / diagnosis. Thymus Neoplasms / diagnosis

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  • (PMID = 19918636.001).
  • [ISSN] 1806-3756
  • [Journal-full-title] Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
  • [ISO-abbreviation] J Bras Pneumol
  • [Language] eng; por
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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91. Matthews A, Tang M, Cooper K: Cytogenetic aberrations in soft tissue tumors harvested from fresh tissue submitted for surgical pathology: a single institutional experience. Int J Surg Pathol; 2010 Aug;18(4):260-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytogenetic aberrations in soft tissue tumors harvested from fresh tissue submitted for surgical pathology: a single institutional experience.
  • AIMS: Recurrent cytogenetic abnormalities have been reported in many types of soft tissue neoplasms, and the detection of these aberrations imparts diagnostic utility.
  • The aim of this study is to demonstrate that classical karyotyping may be performed with minimal effort as an adjunct to surgical pathology on fresh tissue submitted for histopathological examination.
  • To the authors' knowledge, there are no recently published reviews in the literature in English of cytogenetic abnormalities in soft tissue tumors from a single institution.
  • METHODS: Conventional metaphase cytogenetics was performed in the authors' cytogenetics laboratory on fresh tissue from mesenchymal tumors from their surgical pathology laboratory over a period of 4 years.
  • Cytogenetics reports, clinical history, and histopathology were reviewed for 48 soft tissue tumors.
  • Recurrent cytogenetic abnormalities were identified using the Mitelman Database of Chromosome Aberrations in Cancer and a review of the literature.
  • RESULTS: The authors reviewed 48 cases of benign and malignant soft tissue tumors, which included 28 distinct morphologies.
  • CONCLUSIONS: Cytogenetic analysis demonstrated abnormal karyotypes in nearly half of this series of mesenchymal neoplasms, the majority of which consisted of recognized aberrations reported in the literature.
  • [MeSH-major] Chromosome Aberrations. Pathology, Surgical / methods. Sarcoma / genetics. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Infant. Karyotyping. Male. Middle Aged. Neoplasm Recurrence, Local. Young Adult

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  • (PMID = 19776087.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Nilsson M, Domanski H, Mertens F, Mandahl N: Atypical lipomatous tumor with rare structural rearrangements involving chromosomes 8 and 12. Oncol Rep; 2005 Apr;13(4):649-52
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  • [Title] Atypical lipomatous tumor with rare structural rearrangements involving chromosomes 8 and 12.
  • Atypical lipomatous tumor (ALT), an intermediate malignant neoplasm of soft tissues, is characterized by the presence of supernumerary ring and giant marker chromosomes.
  • These supernumerary chromosomes consistently contain amplified 12q-material in association with amplified segments from a variety of other chromosomes.
  • However, a few cases of ALT with other types of chromosomal rearrangements have been reported earlier.
  • These findings are consistent with previous reports that the ALT phenotype may be associated with a low or moderate level of gene amplification, whereas truncation of HMGA2 has been observed in both ALTs and benign lipomas.
  • Whether ALTs with these types of aberrations have a lower risk of tumor progression than ALTs with the notoriously mitotically unstable ring and giant marker chromosomes remains to be investigated.
  • [MeSH-major] Chromosome Aberrations. Chromosomes, Human, Pair 12. Chromosomes, Human, Pair 8. Lipoma / genetics. Lipoma / pathology. Neoplasms, Adipose Tissue / genetics. Neoplasms, Adipose Tissue / pathology

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  • (PMID = 15756437.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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93. Mutlu H, Silit E, Pekkafali Z, Basekim CC, Ozturk E, Sildiroglu O, Kizilkaya E, Karsli AF: Soft-tissue masses: use of a scoring system in differentiation of benign and malignant lesions. Clin Imaging; 2006 Jan-Feb;30(1):37-42
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  • [Title] Soft-tissue masses: use of a scoring system in differentiation of benign and malignant lesions.
  • The purpose of this study was to show the qualitative and quantitative MRI characteristics of soft-tissue masses in differentiation of benign and malignant lesions.
  • A total of 90 soft-tissue lesions were reviewed in this study.
  • The scoring system presents a more objective diagnostic performance in the prediction of benign or malignant masses.
  • With the use of this scoring system, unnecessary biopsy can be precluded in benign lesions.
  • [MeSH-major] Magnetic Resonance Imaging. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Arteriovenous Malformations / diagnosis. Diagnosis, Differential. Fibrosarcoma / diagnosis. Hemangioma / diagnosis. Histiocytoma / diagnosis. Humans. Neoplasm Metastasis / diagnosis. Predictive Value of Tests. Retrospective Studies. Rhabdomyosarcoma / diagnosis

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  • (PMID = 16377483.001).
  • [ISSN] 0899-7071
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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94. Wang HY, Fan QH, Gong QX, Wang Z: [Clinicopathologic characteristics of hemangiopericytoma/solitary fibrous tumor with giant cells]. Zhonghua Bing Li Xue Za Zhi; 2009 Mar;38(3):169-72
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  • [Title] [Clinicopathologic characteristics of hemangiopericytoma/solitary fibrous tumor with giant cells].
  • OBJECTIVE: To study the pathological characteristics, diagnosis and differential diagnoses of hemangiopericytoma-solitary fibrous tumor with giant cells.
  • Seven patients underwent tumor excision and were well and without tumor recurrence upon the clinical follow-up.
  • CONCLUSIONS: Hemangiopericytoma-solitary fibrous tumor with giant cells is an intermediate soft tissue tumor.
  • Histologically, the tumor should be distinguished from giant cell fibroblastoma, pleomorphic hyalinzing angiectatic tumor of soft part and angiomatoid fibrous histiocytoma.
  • [MeSH-major] Hemangiopericytoma / pathology. Orbital Neoplasms / pathology. Solitary Fibrous Tumors / pathology
  • [MeSH-minor] Adult. Antigens, CD / metabolism. Antigens, CD34 / metabolism. Cell Adhesion Molecules / metabolism. Dermatofibrosarcoma / pathology. Diagnosis, Differential. Female. Follow-Up Studies. Histiocytoma, Benign Fibrous / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Recurrence, Local. Proto-Oncogene Proteins c-bcl-2 / metabolism. Soft Tissue Neoplasms / pathology. Solitary Fibrous Tumor, Pleural / metabolism. Solitary Fibrous Tumor, Pleural / pathology. Solitary Fibrous Tumor, Pleural / surgery. Young Adult

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  • (PMID = 19575851.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Proto-Oncogene Proteins c-bcl-2
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95. Rakoto-Ratsimba HN, Razafimahandry HJ, Tsiaviry P, Rakototiana A, Rakotozafy G: [Digital myxoma. A case report and review of the literature]. Chir Main; 2005 Oct;24(5):270-2
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  • [Transliterated title] Localisation digitale d'un myxome. A propos d'un cas et revue de la littérature.
  • Myxoma is a benign mesenchymatous neoplasm, but can be locally invasive.
  • [MeSH-major] Fingers. Myxoma. Soft Tissue Neoplasms

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  • (PMID = 16277155.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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96. Dias PF, Pedro Rde L, Janine ME, Maia LC: Congenital epulis: an unusual case of spontaneous regression. Gen Dent; 2008 Jul-Aug;56(5):e25-7
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  • Congenital epulis is a rare benign neoplasm of the soft tissues.
  • This article reports an unusual case of a girl whose dentist diagnosed congenital epulis when she was 16 months old; the epulis disappeared completely three months later.
  • [MeSH-major] Gingival Neoplasms / congenital. Neoplasm Regression, Spontaneous / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Follow-Up Studies. Humans. Infant

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  • (PMID = 21444268.001).
  • [ISSN] 0363-6771
  • [Journal-full-title] General dentistry
  • [ISO-abbreviation] Gen Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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97. Hong R, Lim SC: Granular cell tumor of the cecum with extensive hyalinization and calcification: a case report. World J Gastroenterol; 2009 Jul 14;15(26):3315-8
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  • [Title] Granular cell tumor of the cecum with extensive hyalinization and calcification: a case report.
  • A granular cell tumor (GCT) is a benign neoplasm of unclear histogenesis that is generally believed to be of nerve sheath origin.
  • GCT is not common and most often affects the tongue, skin and soft tissue, although it may occur anywhere in the body.
  • We experienced a case of GCT that arose in the cecum of a 55-year-old man.
  • In addition to the tumor, endoscopic examination revealed the presence of a 5-mm-polyp in the descending colon and multiple tiny polyps in the sigmoid colon and rectum.
  • Histological examination demonstrated a cecal tumor 1.5 cm x 1.0 cm x 0.7 cm with a hard consistency; in cut sections, mixed cells with yellowish and whitish portions were seen.
  • The tumor was located between the mucosa and subserosa, and was composed of plump histiocyte-like tumor cells with abundant granular eosinophilic cytoplasm, which were immunoreactive for S-100 protein, vimentin, neuron-specific enolase, inhibin-alpha and calretinin.
  • The tumor showed extensive hyalinization and focal dystrophic calcification.
  • Extensive hyalinization and calcification showing involution of tumor cells suggest benign clinical behavior of GCT.
  • [MeSH-major] Calcinosis / pathology. Cecum / pathology. Granular Cell Tumor / pathology. Hyalin / metabolism
  • [MeSH-minor] Biomarkers, Tumor. Calbindin 2. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / pathology. Humans. Male. Middle Aged. Phosphopyruvate Hydratase. S100 Calcium Binding Protein G. S100 Proteins. Vimentin

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  • (PMID = 19598311.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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  • [Other-IDs] NLM/ PMC2710791
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98. Ritchie DA, Aniq H, Davies AM, Mangham DC, Helliwell TR: Hibernoma--correlation of histopathology and magnetic-resonance-imaging features in 10 cases. Skeletal Radiol; 2006 Aug;35(8):579-89
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  • OBJECTIVE, DESIGN AND PATIENTS: Hibernoma is an uncommon, slow-growing, benign soft-tissue tumour resembling brown adipose tissue.
  • [MeSH-major] Magnetic Resonance Imaging. Neoplasms, Adipose Tissue / pathology

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  • (PMID = 16642344.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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99. Pichi B, Manciocco V, Marchesi P, Pellini R, Ruscito P, Vidiri A, Covello R, Spriano G: Rhabdomyoma of the parapharyngeal space presenting with dysphagia. Dysphagia; 2008 Jun;23(2):202-4
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  • Rhabdomyoma is an exceedingly rare soft tissue benign tumor of skeletal muscle origin classified into cardiac and extracardiac types based on location.
  • Adult rhabdomyomas are rare, but morphologically characteristic, benign mesenchymal tumors with mature skeletal muscle differentiation that in 90% of cases arise in the head and neck region, mainly in the mucosa of the oropharynx, nasopharynx, and larynx, from the branchial musculature of third and fourth branchial arches.
  • [MeSH-major] Deglutition Disorders / etiology. Oropharyngeal Neoplasms / complications. Oropharyngeal Neoplasms / pathology. Rhabdomyoma / complications. Rhabdomyoma / pathology

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  • (PMID = 17965913.001).
  • [ISSN] 0179-051X
  • [Journal-full-title] Dysphagia
  • [ISO-abbreviation] Dysphagia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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100. Boneschi V, Parafioriti A, Armiraglio E, Gaiani F, Brambilla L: Primary giant cell tumor of soft tissue of the groin - a case of 46 years duration. J Cutan Pathol; 2009 Oct;36 Suppl 1:20-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary giant cell tumor of soft tissue of the groin - a case of 46 years duration.
  • BACKGROUND: Soft tissue giant cell tumor (GCT-ST) of low malignant potential is an uncommon neoplasm, considered the soft tissue counterpart of giant cell tumor of bone.
  • Histologically, this tumor is characterized by a mixture of uniformly scattered osteoclast-like multinucleated giant cells intimately admixed with short fascicles of spindled cells.
  • Complete excision with negative surgical margins is associated with a benign clinical course in most cases.
  • RESULTS: Histologically, the tumor was characterized by a multinodular growth pattern with osteoclast-like multinucleated giant cells admixed with spindle cells partially arranged in a storiform pattern, fibrosis and foci of haemorrhage and mature bone.
  • CONCLUSION: GCT-ST is a rare neoplasm characterized by benign clinical course if excised adequately, as shown by our case of exceptionally long duration.
  • Emphasis is placed on the importance of differential diagnosis with other giant cell-rich soft tissue neoplasms because clinical behaviour, prognosis and treatment significantly differ.
  • [MeSH-major] Giant Cell Tumors / pathology. Groin / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Age of Onset. Aged. Antigens, CD / biosynthesis. Antigens, Differentiation, Myelomonocytic / biosynthesis. Biopsy. Diagnostic Errors. Humans. Immunohistochemistry. Male. Sarcoma, Kaposi / diagnosis

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  • (PMID = 19222697.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human
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