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1. Bailey AA, Debinski HS, Appleyard MN, Remedios ML, Hooper JE, Walsh AJ, Selby WS: Diagnosis and outcome of small bowel tumors found by capsule endoscopy: a three-center Australian experience. Am J Gastroenterol; 2006 Oct;101(10):2237-43
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  • [Title] Diagnosis and outcome of small bowel tumors found by capsule endoscopy: a three-center Australian experience.
  • OBJECTIVE: The objective of the study was to examine diagnosis and outcome in a series of patients with small bowel tumors detected by capsule endoscopy (CE) in three Australian centers.
  • Clinical parameters, tumor histology, and follow-up are reported.
  • Indications for CE were obscure gastrointestinal (GI) bleeding (21), suspected tumor (3), abdominal pain (1), diarrhea (1).
  • Nine tumors were proven benign: hamartoma (4), cystic lymphangioma (1), primary amyloid (1), lipoma (1).
  • CONCLUSIONS: Small bowel tumors are a significant finding at CE and are often missed by other methods of investigation.
  • In many patients, detection of a tumor alters management and improves outcome.
  • [MeSH-major] Capsule Endoscopy. Intestinal Neoplasms / pathology. Intestinal Neoplasms / therapy. Intestine, Small

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  • (PMID = 17032187.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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2. Van Kerkhóve F, Coenegrachts K, Steyaert L, Van Den Berghe I, Casselman JW: Collision tumor in the ileum: a rare combination of an adenocarcinoma and small cell neuroendocrine tumor. JBR-BTR; 2006 Sep-Oct;89(5):258-60
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  • [Title] Collision tumor in the ileum: a rare combination of an adenocarcinoma and small cell neuroendocrine tumor.
  • We present a case of a rare small bowel tumor.
  • Ultrasound examination discovered an inhomogeneous vascularised mass originating from a small bowel loop, mesenteric enlarged lymph nodes and a nodule in the liver.
  • Pathology revealed a rare ileal collision tumor consisting of an adenocarcinoma and a small cell neuroendocrine tumor with peritoneal metastasis of neuroendocrine origin and coincidental benign lesions on both ovaries.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma, Villous / diagnosis. Adenomatous Polyps / diagnosis. Carcinoma, Small Cell / diagnosis. Ileal Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Tomography, X-Ray Computed. Ultrasonography
  • [MeSH-minor] Adenofibroma / diagnosis. Adenofibroma / pathology. Adenofibroma / surgery. Aged. Cystadenoma / diagnosis. Cystadenoma / pathology. Cystadenoma / surgery. Female. Fibroma / diagnosis. Fibroma / pathology. Fibroma / surgery. Humans. Ileum / pathology. Ileum / surgery. Intestinal Mucosa / pathology. Intestinal Mucosa / surgery. Liver / pathology. Liver / surgery. Lymphatic Metastasis / pathology. Mesentery / pathology. Mesentery / surgery. Omentum / pathology. Omentum / surgery. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / pathology. Ovarian Neoplasms / surgery. Ovariectomy. Ovary / pathology. Peritoneum / pathology. Peritoneum / surgery


3. Kianmanesh R, O'toole D, Sauvanet A, Ruszniewski P, Belghiti J: [Surgical treatment of gastric, enteric, and pancreatic endocrine tumors Part 1. Treatment of primary endocrine tumors]. J Chir (Paris); 2005 May-Jun;142(3):132-49
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  • [Transliterated title] Traitement chirurgical des tumeurs endocrines gastro-entéro-pancréatiques.
  • Endocrine tumors (ET) of the digestive tract (formerly called neuroendocrine tumors) are rare.
  • They are classified into two principal types: gastrointestinal ET's (formerly called carcinoid tumors) which are the most common, and pancreaticoduodenal ET's.
  • Functioning ET's secrete polypeptide hormones which cause characteristic hormonal syndromes.
  • The management of ET is multidisciplinary.
  • Poorly-differentiated ET's have a poor prognosis and are treated by chemotherapy.
  • Surgical excision is the only curative treatment of well-differentiated ET's.
  • The surgical goals are to: 1. prolong survival by resecting the primary tumor and any nodal or hepatic metastases, 2. control the symptoms related to hormonal secretion, 3. prevent or treat local complications.
  • The most common sites of gastrointestinal ET's ( carcinoids) are the appendix and the rectum; these are often small (<1 cm), benign, and discovered fortuitously at the time of appendectomy or colonoscopic removal.
  • Ileal ET's, even if small, are malignant, frequently multiple, and complicated in 30-50% of cases by bowel obstruction, mesenteric invasion, or bleeding.
  • More than half of the cases of pancreatic ET are non-functional.
  • They are usually malignant and of advanced stage at diagnosis presenting as a palpable or obstructing mass or as liver metastases.
  • Insulinoma and gastrinoma (cause of the Zollinger-Ellison syndrome) are the most common functional ET's. 80% are sporadic; in these cases, tumor size, location, and malignant potential determine the type of resection which may vary from a simple enucleation to a formal pancreatectomy.
  • In 10-20% of cases, pancreaticoduodenal ET presents in the setting of multiple endocrine neoplasia (NEM type I), an autosomal-dominant genetic disease with multifocal endocrine involvement of the pituitary, parathyroid, pancreas, and adrenal glands.
  • The lesions are frequently small, multiple, and widespread and recurrence is frequent after excision.
  • [MeSH-major] Carcinoid Tumor / surgery. Carcinoma, Islet Cell / surgery. Carcinoma, Neuroendocrine / surgery. Insulinoma / surgery. Intestinal Neoplasms / surgery. Multiple Endocrine Neoplasia Type 1 / surgery. Pancreatic Neoplasms / surgery. Stomach Neoplasms / surgery. Zollinger-Ellison Syndrome / surgery
  • [MeSH-minor] Adult. Gastrinoma / diagnosis. Gastrinoma / surgery. Glucagonoma / diagnosis. Glucagonoma / surgery. Humans. Liver Neoplasms / secondary. Lymphatic Metastasis. Malignant Carcinoid Syndrome / diagnosis. Malignant Carcinoid Syndrome / surgery. Multicenter Studies as Topic. Pancreatectomy. Postoperative Care. Postoperative Complications. Prognosis. Somatostatinoma / diagnosis. Somatostatinoma / surgery. Vipoma / diagnosis. Vipoma / surgery

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  • (PMID = 16142076.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 236
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4. Yu DC, Javid PJ, Chikwava KR, Kozakewich HP, Debiec-Rychter M, Lillehei CW, Weldon CB: Mesenteric lipoblastoma presenting as a segmental volvulus. J Pediatr Surg; 2009 Feb;44(2):e25-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Mesenteric lipoblastoma is a rare tumor and, its presentation as a bowel obstruction with possible midgut volvulus has only been reported once before.
  • A 7-year-old girl presented with nausea and vomiting but a benign abdominal examination.
  • During emergency laparotomy, segmental small bowel volvulus secondary to a large mesenteric lipoblastoma was found.
  • The lipoblastoma was resected with a segment of small bowel.
  • Resection margins were negative for tumor, and the patient is doing well with no evidence of recurrence.
  • [MeSH-major] Intestinal Obstruction / etiology. Intestinal Volvulus / etiology. Intestine, Small. Mesentery. Peritoneal Neoplasms / complications

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  • (PMID = 19231517.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Tivadar B, Serban B, Mircea M, Tivadar B Jr, Leonard A, Daniela P, Simona M: Late hepatic metastasis in the evolution of gastrointestinal stromal tumors. Hepatogastroenterology; 2010 Jan-Feb;57(97):95-7
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  • Gastro-intestinal stromal tumours develop in the digestive tract wall, in the undifferentiated mesenchymal cells with a starting point at the level of the interstitial cells of Cajal.
  • Gastro-intestinal stromal tumours often lead to peritoneal and hepatic metastasis.
  • A special attention should be paid to localization, serosal invasion, mucous ulceration, size of the tumor and mitotic index, in order to set the prognosis of the patient.
  • We here by present two cases of gastro-intestinal stromal tumours one with gastric location and one jejunal tumor with ulceration and hemorrhage, of small sizes, initially diagnosed as benign but developing in the late evolution liver metastases.


6. Merchant NB, Parikh AA, Kooby DA: Should all distal pancreatectomies be performed laparoscopically? Adv Surg; 2009;43:283-300
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  • There are both enough experience and data (though retrospective) to confirm that LDP with or without spleen preservation appears to be a safe treatment for benign or noninvasive lesions of the pancreas.
  • Based on the fact that LDP can be performed with similar or shorter operative times, blood loss, complication rates, and length of hospital stay than ODP, it can be recommended as the treatment of choice for benign and noninvasive lesions in experienced hands when clinically indicated.
  • Certainly more data, preferably in the manner of a randomized clinical trial, are needed before additional recommendations can be made.
  • While this report is underpowered, it supports the notion that MIS cancer surgery may induce less of a systemic insult to the body than standard open cancer surgery.
  • Additional areas of discovery are in staple line reinforcement for left pancreatectomy and suturing technology for pancreatico-intestinal anastomosis.
  • Can we enucleate a small tumor off the pancreatic body by passing an endoscope through the gastric (or colonic) wall, and bring the specimen out via the mouth or anus?

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  • (PMID = 19845186.001).
  • [ISSN] 0065-3411
  • [Journal-full-title] Advances in surgery
  • [ISO-abbreviation] Adv Surg
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 95
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7. Biermann K, Heukamp LC, Büttner R, Zhou H: Uterine tumor resembling an ovarian sex cord tumor associated with metastasis. Int J Gynecol Pathol; 2008 Jan;27(1):58-60
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  • [Title] Uterine tumor resembling an ovarian sex cord tumor associated with metastasis.
  • Uterine tumors resembling ovarian sex-cord tumors (UTROSCT) are very rare, usually benign uterine tumors, and are probably derived from uterine mesenchymal stem cells.
  • In this case report, a unique case of a malignant UTROSCT is described.
  • Four years after a diagnosis of UTROSCT of the uterine corpus, the patient developed obstructive ileus due to a large infiltrating tumor within the small bowel with the same morphology and expression pattern as the previously diagnosed UTROSCT.
  • In addition, 2 benign gastrointestinal stromal tumors were detected in the same patient.
  • This case indicates that although the majority of UTROSCT are benign tumors, some of them might undergo malignant transformation and have a metastatic potency.
  • [MeSH-major] Intestinal Neoplasms / secondary. Ovarian Neoplasms / pathology. Sex Cord-Gonadal Stromal Tumors / pathology. Uterine Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Female. Gastrointestinal Stromal Tumors / metabolism. Gastrointestinal Stromal Tumors / pathology. Humans. Immunohistochemistry. Intestinal Obstruction / etiology. Intestine, Small / metabolism. Intestine, Small / pathology. Neoplasms, Second Primary / metabolism. Neoplasms, Second Primary / pathology

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  • (PMID = 18156976.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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8. Miettinen M, Kraszewska E, Sobin LH, Lasota J: A nonrandom association between gastrointestinal stromal tumors and myeloid leukemia. Cancer; 2008 Feb 1;112(3):645-9
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  • These tumors most commonly occur in the stomach and small intestine and encompass a clinical spectrum from benign to malignant.
  • BACKGROUND: Nine patients (2 with gastric GISTs and 7 with GISTs of the small intestine) developed myeloid leukemia.
  • None of the GIST patients had received radiotherapy or chemotherapy prior to the leukemia diagnosis.
  • All but 1 GIST case was found to have a low mitotic rate (0-1 per 50 high-power fields); however, tumor size varied from 3 to 18 cm (median, 4.5 cm).
  • [MeSH-major] Gastrointestinal Stromal Tumors / epidemiology. Intestinal Neoplasms / epidemiology. Leukemia, Myeloid / epidemiology. Stomach Neoplasms / epidemiology


9. Papalambros A, Petrou A, Brennan N, Bramis K, Felekouras E, Papalambros E: GIST suture-line recurrence at a gastrojejunal anastomosis 8 years after gastrectomy: can GIST ever be described as truly benign? A case report. World J Surg Oncol; 2010;8:90
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  • [Title] GIST suture-line recurrence at a gastrojejunal anastomosis 8 years after gastrectomy: can GIST ever be described as truly benign? A case report.
  • We present the case of a 71 year old man with recurrence of a Gastro Intestinal Stromal Tumour (GIST) at the gastrojejunal anastomosis eight years following partial gastrectomy for a very small primary gastric GIST.
  • The histopathology was in keeping with a diagnosis of a gastric GIST with a <2 cm tumour, with <5 mitosis per 50/HPF, no signs of necrosis and invasion limited to the mucosa.
  • He subsequently underwent completion gastrectomy and the histology revealed a 0.8 cm GIST tumour composed of spindle cells with <5 mitosis per 50/HPF, tumor invasion into the submucosa and positive expression of c-kit and SMA.
  • The literature suggests that tumour size, mitotic rate and tumour site are the most important predictive factors of recurrence.
  • Additional features such as the presence of necrosis, local tumour invasion and positive resection margins, can also influence recurrence rates.
  • In this case the lesion was a gastric GIST, very small (<2 cm), had low proliferation rate (<5 mitosis/HPF), lacked necrosis and was limited to the mucosa.
  • This case highlights how even the most innocent GISTs can never be described as truly benign.
  • [MeSH-major] Gastrectomy / methods. Gastrointestinal Stromal Tumors / surgery. Jejunum / surgery. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Stomach / surgery. Stomach Neoplasms / surgery

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  • (PMID = 20946677.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2965163
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10. Kim SG: [Incidental gastrointestinal subepithelial mass]. Korean J Gastroenterol; 2010 Dec;56(6):341-5
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  • Most of gastrointestinal subepithelial mass are small-sized and asymptomatic tumor with benign nature, but gastrointestinal stromal tumor should be ruled-out because of its malignant behavior.
  • Although conventional endoscopy alone can differentiate the nature of subepithelial mass, more accurate diagnosis can be achieved with endoscopic ultrasonography and its guided biopsy.
  • In this review, differential diagnosis and treatment strategy of incidental gastrointestinal subepithelial mass would be presented.
  • [MeSH-major] Gastrointestinal Stromal Tumors / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Endoscopy, Gastrointestinal. Humans. Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / diagnostic imaging. Intestinal Neoplasms / pathology. Stomach Neoplasms / diagnosis. Stomach Neoplasms / diagnostic imaging. Stomach Neoplasms / pathology. Tomography, X-Ray Computed. Ultrasonography

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  • (PMID = 21173556.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Journal Article; Review
  • [Publication-country] Korea (South)
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11. Shah SN: Malignant gastrointestinal stromal tumor of intestine: a case report. Indian J Pathol Microbiol; 2007 Apr;50(2):357-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant gastrointestinal stromal tumor of intestine: a case report.
  • Cancer of small intestine comprises less than 20% of all malignant tumors.
  • He was diagnosed as a case of acute intestinal obstruction and on laparotomy an extraluminal mass was found at jejunoileal junction.
  • Histopathology revealed a malignant gastrointestinal stromal tumor (GIST) which was confirmed by immunohistochemistry.
  • The case is reported with review of literature and criteria for differentiation between benign and malignant tumors are enumerated.
  • [MeSH-major] Gastrointestinal Stromal Tumors / pathology. Intestinal Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Ileal Neoplasms / pathology. Jejunal Neoplasms / pathology. Male

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  • (PMID = 17883072.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 13
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12. Kelly RJ, Barrett C, Swan N, McDermott R: Metastatic phyllodes tumor causing small-bowel obstruction. Clin Breast Cancer; 2009 Aug;9(3):193-5
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  • [Title] Metastatic phyllodes tumor causing small-bowel obstruction.
  • Cystosarcoma phyllodes is an important but relatively uncommon fibroepithelial breast neoplasm that accounts for 0.5%-1.0% of female breast carcinomas.
  • Metastases to the small intestine are extremely rare, with only 1 case of metastatic spread to the duodenum reported in the literature.
  • No previous reports of metastatic spread to the ileum have been published.
  • This report highlights a unique case of a metastatic phyllodes breast tumor leading to small bowel obstruction.
  • Phyllodes tumors are generally classified into histologic subtypes of benign, intermediate, and malignant, using agreed classification systems.
  • The tumor characteristics that can lead to the dedifferentiation of a relatively benign phenotype to an overt malignant process are discussed.
  • [MeSH-major] Breast Neoplasms / pathology. Ileal Neoplasms / secondary. Intestinal Obstruction / etiology. Phyllodes Tumor / pathology
  • [MeSH-minor] Antibiotics, Antineoplastic / administration & dosage. Antineoplastic Agents, Alkylating / administration & dosage. Combined Modality Therapy. Doxorubicin / administration & dosage. Female. Humans. Ifosfamide / administration & dosage. Mastectomy. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 19661046.001).
  • [ISSN] 1938-0666
  • [Journal-full-title] Clinical breast cancer
  • [ISO-abbreviation] Clin. Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Alkylating; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
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13. Safioleas MC, Constantinos K, Michael S, Konstantinos G, Constantinos S, Alkiviadis K: Benign multicystic peritoneal mesothelioma: a case report and review of the literature. World J Gastroenterol; 2006 Sep 21;12(35):5739-42
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  • [Title] Benign multicystic peritoneal mesothelioma: a case report and review of the literature.
  • Benign multicystic peritoneal mesothelioma (BMPM) is a rare tumor that occurs mainly in women in their reproductive age.
  • The pathogenesis of BMPM is unclear and a controversy regarding its neoplastic and reactive nature exists.
  • Upright plain abdominal film revealed small bowel loops with air-fluid levels.
  • She was diagnosed having an incarcerated incisional hernia that resulted in intestinal obstruction.
  • The patient underwent surgery during which a cystic mass of the right ovary measuring 6 cm multiply 5 cm multiply 4 cm, four small cysts of the small bowel (1 cm in diameter) and a cyst at the retroperitoneum measuring 11 cm multiply 10 cm multiply 3 cm were found.
  • [MeSH-major] Mesothelioma, Cystic / diagnosis. Mesothelioma, Cystic / pathology. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Neoplasm Recurrence, Local. Neoplasms / diagnosis. Neoplasms / etiology. Neoplasms / pathology. Neoplasms / surgery


14. Zang L, Hu WG, Yan XW, Zhang T, Ma JJ, Ye Q, Feng B, Wang ML, Lu AG, Li JW, Zhong J, Zheng MH: Laparoscopic treatment for small intestinal bleeding: a report of 77 cases. J Laparoendosc Adv Surg Tech A; 2010 Jul-Aug;20(6):521-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic treatment for small intestinal bleeding: a report of 77 cases.
  • BACKGROUND: Morbidity of small intestinal disease is rare and the associated lesion is hard to be detected due to lack of specific manifestations and effective diagnostic approaches.
  • Hematochezia and melena are the most common symptoms in small intestinal diseases.
  • Hence, small intestinal disease is an important differential diagnosis when hematochezia or melena occurs, especially when gastric and colonic diseases are excluded.
  • As the small intestinal lesion is hard to be located preoperatively, laparotomy used to be performed without a preoperative location.
  • With the development of laparoscopic technique, laparoscopic operations are more frequently applied to surgical disease, despite their benign or malignant nature.
  • Generally, almost all kinds of small intestinal disease can be treated with laparoscopic surgery.
  • METHODS: Clinical data of 77 patients with small intestinal bleeding undergoing laparoscopic or laparoscopy-assisted operations from April 2003 to December 2008 were included, and their clinical information were analyzed retrospectively.
  • There was 1 case of gastrointestinal stromal tumor with local recurrence and hepatic metastasis.
  • CONCLUSIONS: Laparoscopic treatment in small intestinal bleeding is feasible, safe, and minimally invasive.
  • It may be widely used in the future for its good therapeutic outcomes and improved diagnostic chance in small intestinal bleeding diseases.
  • [MeSH-major] Gastrointestinal Hemorrhage / surgery. Intestine, Small. Laparoscopy
  • [MeSH-minor] Adolescent. Adult. Aged. Blood Loss, Surgical. Female. Humans. Intestinal Neoplasms / diagnosis. Length of Stay. Male. Melena / diagnosis. Middle Aged. Postoperative Complications. Retrospective Studies. Treatment Outcome

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  • [CommentIn] J Laparoendosc Adv Surg Tech A. 2010 Nov;20(9):771 [20874417.001]
  • (PMID = 20687815.001).
  • [ISSN] 1557-9034
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Zuccarello C, Arena F, Fazzari C, Arena S, Nicòtina PA: Small bowel intussusception by local recurrence of an inflammatory myofibroblastic tumor: report of a case and review of the literature. Minerva Pediatr; 2006 Oct;58(5):495-8
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  • [Title] Small bowel intussusception by local recurrence of an inflammatory myofibroblastic tumor: report of a case and review of the literature.
  • Inflammatory myofibroblastic tumor (IMT) of the ileum is a rare, usually solitary lesion, that frequently presents small-intestinal intussusception and obstruction.
  • We describe an IMT of the ileum in a 4.5-year old child who presented a small bowel intussusception.
  • During laparotomy, an annular mass around the ileum was resected, and the IMT was histologically diagnosed.
  • Three months after the operation, the patients were hospitalized with the symptoms of intestinal obstruction.
  • Along the previous suture line of anastomosis, a smooth polypoid tumor was evident.
  • Segmental resection of the ileum, including the tumor mass, was performed.
  • A review of the literature for this rare entity emphasizes the importance of immunohistochemical confirmation of its benign nature.
  • [MeSH-major] Ileal Diseases / etiology. Ileal Neoplasms / complications. Intussusception / etiology. Neoplasm Recurrence, Local / complications


16. Coco C, Rizzo G, Manno A, Mattana C, Verbo A: Surgical treatment of small bowel neoplasms. Eur Rev Med Pharmacol Sci; 2010 Apr;14(4):327-33
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  • [Title] Surgical treatment of small bowel neoplasms.
  • Small intestinal neoplasms are uncommon cancers.
  • Benign small intestinal tumors (e.g., leiomyoma, lipoma, hamartoma, or desmoid tumor) usually are asymptomatic but may present with complications.
  • Primary malignancies of the small intestine, including adenocarcinoma, leiomyosarcoma, carcinoid, and lymphoma, are often symptomatic and may present with intestinal obstruction, jaundice, bleeding, or pain.
  • Metastatic neoplasms may involve the small intestine via contiguous spread, peritoneal metastases or hematogenous metastases.
  • Because the small intestine is relatively inaccessible to routine endoscopy, diagnosis of small intestinal neoplasms is often delayed for months after onset of symptoms.
  • During last years the increase of small bowel endoscopy and other diagnostic tools allow earlier non-operative diagnosis.
  • Even though radical resection of small bowel cancer plays an important role, the 5 yr overall survival remains low.
  • [MeSH-major] Intestinal Neoplasms / pathology. Intestinal Neoplasms / surgery. Intestine, Small / pathology. Intestine, Small / surgery
  • [MeSH-minor] Carcinoid Tumor / pathology. Carcinoid Tumor / surgery. Gastrointestinal Stromal Tumors / pathology. Gastrointestinal Stromal Tumors / surgery. Humans. Laparoscopy. Lymphoma / pathology. Lymphoma / surgery. Neoplasm Metastasis

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  • (PMID = 20496543.001).
  • [ISSN] 1128-3602
  • [Journal-full-title] European review for medical and pharmacological sciences
  • [ISO-abbreviation] Eur Rev Med Pharmacol Sci
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 51
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17. Agaimy A, Pelz AF, Wieacker P, Roessner A, Wünsch PH, Schneider-Stock R: Gastrointestinal stromal tumors of the vermiform appendix: clinicopathologic, immunohistochemical, and molecular study of 2 cases with literature review. Hum Pathol; 2008 Aug;39(8):1252-7
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  • Here, we report 2 appendiceal gastrointestinal stromal tumors in a 78-year-old woman and a 72-year-old man with a history of endometrial adenocarcinoma and urinary bladder carcinoma, respectively.
  • The larger gastrointestinal stromal tumor was pedunculated.
  • We suggest that the molecular pathogenesis of appendiceal gastrointestinal stromal tumors beyond initiating KIT mutations might be different from their gastric and intestinal counterparts.
  • The coincidence of loss of p16 and overexpression of human telomerase reverse transcriptase seems to be in contradiction to the small size, the benign nature, and the limited growth potential of appendiceal gastrointestinal stromal tumors.

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  • (PMID = 18547614.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Number-of-references] 21
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18. Chiang JM, Lin YS: Tumor spectrum of adult intussusception. J Surg Oncol; 2008 Nov 1;98(6):444-7
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  • [Title] Tumor spectrum of adult intussusception.
  • PATIENTS AND METHODS: Patients older than 16 years and diagnosed with intestinal intussusception between January 1990 and June 2006 were retrospectively reviewed.
  • Data related to presentation, diagnosis, treatment, and pathology were analyzed.
  • RESULTS: Seventy-two patients underwent surgery for intestinal intussusception.
  • Neoplasm was identified as the cause of intussusception in 66 (92%) cases, and 6 (8%) were idiopathic.
  • Lipoma (15 of 40 patients, 38%) and Peutz-Jegher adenoma (10 of 40 patients, 25%) were the two most common lesions of benign small bowel neoplasms while 27% (3 of 11) of malignant enteric intussusception cases were malignant lymphoma and metastatic respectively.
  • CONCLUSION: Lipoma is the most common benign tumor in both small and large bowel intussusception.
  • Whereas 80% of tumors associated with small bowel intussusception were benign, two-thirds of colonic intussusceptions had resulted from primary adenocarcinoma.
  • [MeSH-major] Intestinal Diseases / etiology. Intestinal Neoplasms / complications. Intussusception / etiology

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • [ErratumIn] J Surg Oncol. 2009 Jun 1;99(7):457
  • (PMID = 18668640.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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19. Lebeau R, Koffi E, Diané B, Amani A, Kouassi JC: [Acute intestinal intussusceptions in adults: analysis of 20 cases]. Ann Chir; 2006 Oct;131(8):447-50
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  • [Title] [Acute intestinal intussusceptions in adults: analysis of 20 cases].
  • [Transliterated title] Invaginations intestinales aiguës de l'adulte: analyse d'une série de 20 cas.
  • AIM OF THE STUDY: To report our experience in the management of acute intestinal intussusceptions in adults.
  • PATIENTS AND METHODS: Retrospective study of data of patients older than 15 years who were operated on for acute intestinal intussusceptions from January 1997 to December 2001.
  • The clinical and radiological findings were suggestive of bowel obstruction (N = 14), peritonitis (N = 5) and appendicular abscess (N = 1).
  • Correct preoperative diagnosis of acute intestinal intussusceptions was established in 6 cases.
  • Type of intussusception was jejunojejunal (N = 1), ileo-ileal (N = 8), ileocolic (N = 1), ileocecocolic (N = 7) and colocolic (N = 3).
  • Necrosis was found in the intussusceptum in 10 cases and a tumor on the lead point in 14 cases (5 benign lesions and 9 malignant ones).
  • For intussusception involving the colon, all patients underwent en bloc resection with immediate anastomosis, while intussusception located on the small bowel were treated by surgical reduction (N = 1), en bloc resection (N = 8) with immediate (N = 7) or delayed (N = 1) anastomosis.
  • CONCLUSION: In our experience, intussusceptions in adults is not an uncommon clinical entity but correct diagnosis is often established peroperatively.
  • En bloc resection is recommended because of the frequency of neoplasms and bowel ischemia.
  • [MeSH-minor] Acute Disease. Adolescent. Adult. Aged. Colectomy. Diagnosis, Differential. Female. Humans. Jejunostomy. Length of Stay. Male. Middle Aged. Retrospective Studies

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  • (PMID = 16765901.001).
  • [ISSN] 0003-3944
  • [Journal-full-title] Annales de chirurgie
  • [ISO-abbreviation] Ann Chir
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
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20. Levin TG, Powell AE, Davies PS, Silk AD, Dismuke AD, Anderson EC, Swain JR, Wong MH: Characterization of the intestinal cancer stem cell marker CD166 in the human and mouse gastrointestinal tract. Gastroenterology; 2010 Dec;139(6):2072-2082.e5
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  • [Title] Characterization of the intestinal cancer stem cell marker CD166 in the human and mouse gastrointestinal tract.
  • Although the presence of CD166 at the tumor cell surface has been correlated with shortened survival, little is known about its function and expression in normal intestinal epithelia.
  • METHODS: We characterized the expression pattern of CD166 in normal intestinal tissue samples from humans and mice using immunohistochemisty, flow cytometry, and quantitative reverse-transcriptase polymerase chain reaction.
  • Human and mouse intestinal tumors were also analyzed.
  • RESULTS: CD166 was expressed on the surface of epithelial cells within the stem cell niche and along the length of the intestine; expression was conserved across species.
  • In the small intestine, CD166 was observed on crypt-based Paneth cells and intervening crypt-based columnar cells (putative stem cells).
  • CD166-positive cells were also detected in benign adenomas in mice; rare cells coexpressed CD166 and CD44 or epithelial-specific antigen.
  • CONCLUSIONS: CD166 is highly expressed within the endogenous intestinal stem cell niche.
  • CD166-positive cells appear at multiple stages of intestinal carcinoma progression, including benign and metastatic tumors.
  • Further studies should investigate the function of CD166 in stem cells and the stem cell niche, which might have implications for normal intestinal homeostasis.

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  • [Copyright] Copyright © 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
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  • (PMID = 20826154.001).
  • [ISSN] 1528-0012
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA118235; United States / NIDDK NIH HHS / DK / U01 DK085525-02; United States / NHLBI NIH HHS / HL / T32 HL007781; United States / NCI NIH HHS / CA / CA106195-06A1; United States / NCI NIH HHS / CA / CA118235-05; United States / NICHD NIH HHS / HD / T32 HD049309-05; United States / NCI NIH HHS / CA / CA106195; United States / NCI NIH HHS / CA / T32 CA106195; United States / NICHD NIH HHS / HD / HD049309; United States / NICHD NIH HHS / HD / T32 HD049309; United States / NCI NIH HHS / CA / T32 CA106195-06A1; United States / NHLBI NIH HHS / HL / T32 HL007781-14; United States / NIDDK NIH HHS / DK / R01 DK068326; United States / NCI NIH HHS / CA / CA118235; United States / NIDDK NIH HHS / DK / R01 DK068326-05; United States / NIDDK NIH HHS / DK / DK068326; United States / NIDDK NIH HHS / DK / DK085525-02; United States / NICHD NIH HHS / HD / HD049309-05; United States / NHLBI NIH HHS / HL / HL007781-14; United States / NHLBI NIH HHS / HL / HL007781; United States / NIDDK NIH HHS / DK / U01 DK085525; United States / NIDDK NIH HHS / DK / DK085525; United States / NIDDK NIH HHS / DK / DK068326-05; United States / NCI NIH HHS / CA / R01 CA118235-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ALCAM protein, human; 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / Cell Adhesion Molecules, Neuronal; 0 / Fetal Proteins
  • [Other-IDs] NLM/ NIHMS234467; NLM/ PMC2997177
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21. Yimyaem P, Saranrittichai S, Sinawat P, Dhiensiri T: Inflammatory myofibroblastic tumor of the small intestine: a case report of a 2 month-old infant. J Med Assoc Thai; 2009 Jan;92(1):114-9
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  • [Title] Inflammatory myofibroblastic tumor of the small intestine: a case report of a 2 month-old infant.
  • Benign intestinal tumors are rare in children; however, the authors describe an inflammatory myofibroblastic tumor (IMT) of the terminal ileum in a 2-month-old infant who presented with an intestinal obstruction.
  • During laparotomy, an annular mass around the terminal ileum was resected, from which a histological diagnosis of IMT was made.
  • A review of the literature for this rare condition was done to delineate the natural history of this tumor and to do a histological confirmation of its benign nature.
  • [MeSH-major] Granuloma, Plasma Cell / pathology. Ileal Diseases / pathology. Intestinal Obstruction / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Infant. Inflammation / pathology. Male. Tomography, X-Ray Computed


22. Lasota J, Wang ZF, Sobin LH, Miettinen M: Gain-of-function PDGFRA mutations, earlier reported in gastrointestinal stromal tumors, are common in small intestinal inflammatory fibroid polyps. A study of 60 cases. Mod Pathol; 2009 Aug;22(8):1049-56
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  • [Title] Gain-of-function PDGFRA mutations, earlier reported in gastrointestinal stromal tumors, are common in small intestinal inflammatory fibroid polyps. A study of 60 cases.
  • The inflammatory fibroid polyp is a rare benign lesion occurring throughout the digestive tract.
  • In this study, PDGFRA exons 12, 14, and 18 were screened for activating mutations in 60 small intestinal inflammatory fibroid polyps.
  • There were 26 deletions, three deletion-insertions, duplication, and single nucleotide substitution in exon 12, and a single nucleotide substitution and deletion in exon 18.
  • A 2664A>T and 2663_2674del leading to 842D>V and D842_H845del, respectively, were identified in exon 18.
  • This study showed consistent expression and common mutational activation of PDGFRA in small intestinal inflammatory fibroid polyps as in their gastric counterparts, and these lesions should be considered PDGFRA-driven benign neoplasms.
  • [MeSH-major] Biomarkers, Tumor / genetics. Intestinal Neoplasms / genetics. Intestinal Polyps / genetics. Leiomyoma / genetics. Receptor, Platelet-Derived Growth Factor alpha / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. DNA Mutational Analysis. Female. Gastrointestinal Stromal Tumors / genetics. Humans. Immunohistochemistry. Intestine, Small / pathology. Male. Middle Aged. Mutation. Polymerase Chain Reaction. Young Adult

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  • (PMID = 19448595.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha
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23. Koay MH, Goh YW, Iacopetta B, Grieu F, Segal A, Sterrett GF, Platten M, Spagnolo DV: Gastrointestinal stromal tumours (GISTs): a clinicopathological and molecular study of 66 cases. Pathology; 2005 Feb;37(1):22-31
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  • AIMS: Predicting the clinical behaviour of gastrointestinal stromal tumours (GISTs) is difficult and criteria delineating benign from malignant cases are not firmly established.
  • (1) appropriate morphology, (2) CD117 positivity, (3) adequacy of pathological material for study, and (4) exclusion of other tumour types on the basis of immunophenotypic and/or ultrastructural features.
  • RESULTS: There were equal numbers of males and females with a mean age at diagnosis of 60 years, followed up for a mean of 54 months.
  • Tumours were mostly located in the stomach (67%) and small intestine (SI; 25%).
  • Size > or = 10 cm, tumour necrosis and pure epithelioid cell morphology each were the only factors significantly associated with adverse survival (p=0.038, and p=0.047 and p=0.028, respectively).
  • c-kit mutations were more frequent in small intestinal GISTs (p=0.05) and in those with pure spindle cell morphology (p=0.023) but were not associated with patient outcome.
  • [MeSH-major] Biomarkers, Tumor / analysis. Gastrointestinal Stromal Tumors / genetics. Gastrointestinal Stromal Tumors / pathology

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  • (PMID = 15875730.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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24. Spaventa-Ibarrola A, Decanini-Terán C, Becerril-Martínez G, Menéndez-Skertchly AL, Golffier-Rosete C: [Ileocecal valve lipoma. Case report and review of the literature]. Cir Cir; 2006 Jul-Aug;74(4):279-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Lipoma de la válvula ileocecal. Informe de un caso clínico y revisión de la literatura.
  • BACKGROUND: Lipomas are the most frequent benign tumors of the digestive tract and 50% are localized in the colon.
  • Most are found submucosally and may vary in their incidence, localization, symptoms and pathogenesis, making diagnosis difficult.
  • CASE PRESENTATION: We present the case of a 78-year-old female with intermittent small bowel occlusion, abdominal distention and constipation.
  • Colonoscopy showed a submucous tumor at the ICV, CT scan showed a tumor at the ICV with fat density.
  • Definitive pathology revealed a benign lipoma.
  • CONCLUSION: It is important to know the different presentations of these benign tumors because if there is mucosal ulceration they can be mistaken for a malignant lesion and lead to greater resections.
  • [MeSH-major] Ileal Neoplasms / diagnosis. Ileocecal Valve. Lipoma / diagnosis
  • [MeSH-minor] Aged. Female. Humans. Intestinal Obstruction / etiology

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  • (PMID = 17022901.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Mexico
  • [Number-of-references] 21
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25. Bruno M, Carucci P, Repici A, Pellicano R, Mezzabotta L, Goss M, Magnolia MR, Saracco GM, Rizzetto M, De Angelis C: The natural history of gastrointestinal subepithelial tumors arising from muscularis propria: an endoscopic ultrasound survey. J Clin Gastroenterol; 2009 Oct;43(9):821-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIM: The majority of lesions originating from muscularis propria of stomach, duodenum, and colon are gastrointestinal stromal tumors (GISTs).
  • Surgery is indicated when endosonographic criteria of malignancy are met, but little is known about the natural history of lesions with benign endosonographic features.
  • Aim of this study was to evaluate the natural course of benign-appearing lesions originating from muscularis propria in organs where GISTs significantly overcome leiomyomas.
  • RESULTS: After a mean follow-up of 31+/-20.8 months and a median of 2 (range, 1 to 5) endosonographies/patient, no change in echostructure or dimensions was seen in 44 subjects whereas in 5, an increase of at least 25% in 1 diameter occurred.
  • Surgical removal was proposed to all: 1 patient refused (she is still alive and symptom-free after 4 y), 3 of the 4 lesions removed proved to be GISTs with very low or low risk of malignancy and 1 lesion was classified as a glomus tumor with no malignant appearance.
  • CONCLUSIONS: Even small and benign-appearing lesions from muscularis propria may increase in size over time but this increase cannot be considered as an index of malignancy.
  • [MeSH-major] Endosonography. Gastric Mucosa / ultrasonography. Gastrointestinal Stromal Tumors / ultrasonography. Intestinal Mucosa / ultrasonography. Intestinal Neoplasms / ultrasonography. Stomach Neoplasms / ultrasonography

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  • (PMID = 19349904.001).
  • [ISSN] 1539-2031
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Nishihara E, Miyauchi A, Hirokawa M, Kudo T, Ohye H, Ito M, Kubota S, Fukata S, Amino N, Kuma K: Benign thyroid teratomas manifest painful cystic and solid composite nodules: three case reports and a review of the literature. Endocrine; 2006 Oct;30(2):231-6
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  • [Title] Benign thyroid teratomas manifest painful cystic and solid composite nodules: three case reports and a review of the literature.
  • Benign thyroid teratomas are rare in adolescents and adults.
  • We report on three cases of benign thyroid teratomas that presented as painful tumors in the neck after puberty.
  • The tumor adjacent to the thyroid in each case showed rapid enlargement with predominant cystic lesions within several months.
  • Ultrasonography and computed tomography revealed few findings suggesting the origin of the tumor.
  • Cytological examination and culture of the aspirate failed to show cells originating from the thyroid or infectious findings, but revealed a small population of columnar epithelial cells or squamous epithelial cells.
  • The patients subsequently underwent resection of the tumor, and microscopic examination revealed various types of tissue including pancreas, adipose, cartilage, muscle, and skin, and the cystic wall was lined by gastric, intestinal, respiratory, and stratified squamous epithelium.
  • Surgical resection was curative, and subsequent histologic examination revealed mature benign teratomas of the thyroid.
  • The main characteristic of our cases presented the painful tumors due to the enlarged cystic formation lined by a variety of different types of epithelium, which agreed with previous cases of benign thyroid teratomas in adolescents and adults.
  • [MeSH-major] Pain / diagnosis. Teratoma / diagnosis. Thyroid Neoplasms / diagnosis. Thyroid Nodule / diagnosis
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Neoplasms / diagnosis

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  • (PMID = 17322585.001).
  • [ISSN] 1355-008X
  • [Journal-full-title] Endocrine
  • [ISO-abbreviation] Endocrine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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27. Ba MC, Qing SH, Huang XC, Wen Y, Li GX, Yu J: Application of laparoscopy in diagnosis and treatment of massive small intestinal bleeding: report of 22 cases. World J Gastroenterol; 2006 Nov 21;12(43):7051-4
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  • [Title] Application of laparoscopy in diagnosis and treatment of massive small intestinal bleeding: report of 22 cases.
  • AIM: To investigate the diagnostic and therapeutic value of laparoscopy in patients with massive small intestinal bleeding.
  • METHODS: Twenty-two patients with massive small intestinal bleeding and hemodynamic alteration underwent laparoscopic laparotomy in our unit from December 2002 to April 2005.
  • Post pathologic sites were found, laparoscopy- or laparoscopy-assisted part small intestinal resection including pathologic intestinal site and enteroanastomosis was performed in all these patients.
  • Massive small intestinal bleeding was caused by jejunum benign stromal tumor in 8 cases, by jejunum potential malignant stromal tumor in 5 cases, by jejunum malignant stromal tumor in 1 case, by Mechel's diverticulum in 5 cases, by small intestinal vascular deformity in 2 cases, and by ectopic pancreas in 1 case.
  • A total of 16 patients underwent laparoscopy-assisted enterectomy and enteroanastomosis of small intestine covering the diseased segment and 6 patients received enterectomy of the diseased segment under laparoscope.
  • CONCLUSION: Laparoscopy in diagnosis and treatment of massive small intestinal bleeding is noninvasive with less pain, short recovery time and definite therapeutic efficacy.
  • [MeSH-major] Anastomosis, Surgical / methods. Gastrointestinal Hemorrhage / diagnosis. Gastrointestinal Hemorrhage / surgery. Intestinal Diseases / diagnosis. Intestinal Diseases / surgery. Intestine, Small / surgery. Laparoscopy / methods

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  • (PMID = 17109505.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4087354
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28. Yang WL, Zhang XC, Yan ZQ, Zhang HM, Zhao Z, Zhang JG, Wang YJ: [Clinical analysis of primary small intestinal neoplasms in 305 cases]. Zhonghua Zhong Liu Za Zhi; 2007 Oct;29(10):781-3
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  • [Title] [Clinical analysis of primary small intestinal neoplasms in 305 cases].
  • OBJECTIVE: To summarive the experience in diagnosis and treatment of primary small intestinal neoplasm.
  • METHODS: The data of 305 patients with pathologically confirmed primary small intestinal tumor collected from 6 hospitals around the Songhua River during the past 33 years were analyzed retrospectively.
  • RESULTS: There were 42 benign and 263 malignant tumors in this series with a ratio of 1: 6.26.
  • Chronic occult bleeding, gradual of body weight loss and mild abdominal pain (three obscurities) were the common clinical features and alerting massage of intestinal tumor.
  • Correct preoperative diagnostic rate was only 57.0% (174/305) due to difficulty in early diagnosis, which was 67.2% (92/137) in the duodenal tumors, and 51.9% (82/168) in the jejunoileal tumors.
  • All of the 42 benign tumors were resected completely.
  • CONCLUSION: Early diagnosis of primary small intestinal tumors is difficult and with a preoperative misdiagnosis rate of 43.0%.
  • Total intestinal barium swallowing, endoscopy and superior mesenteric arteriography are three critical examinations for diagnosis and location.
  • The primary small intestinal tumor should be resected as early as possible if no distant metastasis is detected.
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / pathology. Adenoma / surgery. Adult. Aged. Aged, 80 and over. Carcinoid Tumor / diagnosis. Carcinoid Tumor / secondary. Carcinoid Tumor / surgery. Female. Gastrointestinal Stromal Tumors / diagnosis. Gastrointestinal Stromal Tumors / secondary. Gastrointestinal Stromal Tumors / surgery. Humans. Ileal Neoplasms / diagnosis. Ileal Neoplasms / pathology. Ileal Neoplasms / surgery. Jejunal Neoplasms / diagnosis. Jejunal Neoplasms / pathology. Jejunal Neoplasms / surgery. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Lymphatic Metastasis. Lymphoma / diagnosis. Lymphoma / pathology. Lymphoma / surgery. Male. Middle Aged. Young Adult

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  • (PMID = 18396694.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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29. Kala Z, Válek V, Kysela P, Svoboda T: A shift in the diagnostics of the small intestine tumors. Eur J Radiol; 2007 May;62(2):160-5
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  • [Title] A shift in the diagnostics of the small intestine tumors.
  • Primary, secondary, benign or malignant tumorous diseases of the small intestine are rare.
  • This work should answer the question, whether there is a method of making the diagnosis earlier when the disease is limited and easy to cure.
  • METHODOLOGY: A retrospective study comprising 96 patients having undergone surgery for a small intestine tumor in our hospital from 1996 to 2005 is presented.
  • In the year 1998 we changed our philosophy in trying to directly detect the small intestine pathology and not making the diagnosis by the exclusion only.
  • Intestinal ultrasound was performed on the Ultramark 3000 HDI device with autofocussable convex 5 MHz and linear 7.5 MHz probes or nowadays ATL 5000 HDI, 7-12 MHz linear probe.
  • RESULTS: We treated surgically 96 patients with the small intestine tumor.
  • A shift in the diagnostic algorithm was noticed in the bowel ultrasound now taking the lead.
  • CONCLUSION: The small bowel ultrasound can be recommended as the first choice method.
  • All patients with even very moderate abdominal symptoms ought to be examined for the small intestine pathology.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / surgery. Intestine, Small / pathology. Intestine, Small / surgery
  • [MeSH-minor] Abdomen, Acute / etiology. Abdomen, Acute / surgery. Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Aged. Algorithms. Carcinoid Tumor / diagnosis. Carcinoid Tumor / surgery. Czech Republic. Endoscopy, Gastrointestinal. Endosonography. Female. Follow-Up Studies. Gastrointestinal Hemorrhage / etiology. Humans. Laparoscopy. Lymphoma / diagnosis. Lymphoma / surgery. Male. Melanoma / diagnosis. Melanoma / surgery. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 17344005.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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30. Bogner B, Péter S, Hegedus G: [Inflammatory fibroid polyp of the ileum causing intestinal invagination]. Magy Seb; 2005 Aug;58(4):237-40
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  • [Title] [Inflammatory fibroid polyp of the ileum causing intestinal invagination].
  • Inflammatory fibroid polyps are rare benign tumor-like lesions of the gastrointestinal tract.
  • In the small intestine the ileum is the most common site, where these polyps can cause invagination and intussusception.
  • [MeSH-major] Fibroma / complications. Ileal Neoplasms / complications. Intestinal Polyps / complications. Intussusception / etiology

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  • (PMID = 16261870.001).
  • [ISSN] 0025-0295
  • [Journal-full-title] Magyar sebészet
  • [ISO-abbreviation] Magy Seb
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Hungary
  • [Number-of-references] 13
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31. Kala Z, Kysela P, Meluzinova H: Small-bowel tumors in the elderly 65+ years: 10 years of experience. Z Gerontol Geriatr; 2008 Oct;41(5):403-7
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  • [Title] Small-bowel tumors in the elderly 65+ years: 10 years of experience.
  • Primary, secondary, benign or malignant tumorous diseases of the small intestine are rare.
  • This work represents a prospective evaluation of a diagnostic and therapeutic algorithm in the management of the small-intestine tumor below the ligamentum Treitzi in patients over 65 years of age.
  • RESULTS: A population of 96 patients who underwent surgery for a small-intestinal tumor in our hospital from 1996 to 2006 is presented.
  • Ultrasound of the small intestine was sufficient to make the diagnosis in 21 of them.
  • CONCLUSION: The small-bowel ultrasound can be recommended as the first choice method.
  • [MeSH-major] Intestinal Neoplasms / surgery. Intestinal Neoplasms / ultrasonography. Intestine, Small / surgery. Intestine, Small / ultrasonography. Ultrasonography / methods

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  • (PMID = 18327695.001).
  • [ISSN] 0948-6704
  • [Journal-full-title] Zeitschrift für Gerontologie und Geriatrie
  • [ISO-abbreviation] Z Gerontol Geriatr
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 29
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32. Kan H, Suzuki H, Shinji S, Naito Z, Furukawa K, Tajiri T: Case of an inflammatory fibroid polyp of the cecum. J Nippon Med Sch; 2008 Jun;75(3):181-6
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  • An inflammatory fibroid polyp (IFP) is a rare benign lesion, originating in the submucosa of the gastrointestinal tract.
  • It typically arises in the stomach and small intestine but also arises infrequently in the colon.
  • The lesion was diagnosed to be a submucosal tumor.
  • Immunohistochemical staining of the spindle-shaped cells, which were present around the small vessels in the stroma of the tumor, showed that the tissue expressed vimentin but not alpha-smooth muscle actin, desmin, S-100, c-kit or CD 34.
  • [MeSH-major] Cecal Neoplasms / surgery. Intestinal Polyps / surgery
  • [MeSH-minor] Cecum / pathology. Cecum / surgery. Colonoscopy. Digestive System Surgical Procedures / methods. Female. Humans. Ileum / surgery. Laparoscopy. Lymph Node Excision. Middle Aged. Treatment Outcome

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  • (PMID = 18648178.001).
  • [ISSN] 1345-4676
  • [Journal-full-title] Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
  • [ISO-abbreviation] J Nippon Med Sch
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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33. Drasković M, Misović S, Kronja G, Krsić J, Tomić A, Sarac M: [Jejuno-jejunal intussusception in adults secondary to submucosal leiomyoma]. Med Pregl; 2005 Jul-Aug;58(7-8):405-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Jejuno-jejunal intussusception in adults secondary to submucosal leiomyoma].
  • INTRODUCTION: Intussusception is the invagionation of a segment of the intestine into itself.
  • Intussusception in adults is usually caused by tumors, benign or malignant.
  • Early diagnosis is essential to avoid treatment delays, which can increase morbidity and mortality.
  • In older patinets and adolescents the diagnosis can be complicated due to lower incidence and variable subacute symptoms.
  • CASE REPORT: We report a rare case of a 27-year-old patient with increasing abdominal discomfort over several weeks.
  • Intussusception of the small bowel was diagnosed by CT examination.
  • Laparotomy revealed a jejunojejunal intussusception caused by a small bowel tumor.
  • CONCLUSION: The tumor in the jejunum, almost completely obstructed the intestinal lumen and it was resected and bowel continuity was restored.
  • Histopathological examination revealed a submucosal leiomyoma of the jejunum.

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  • (PMID = 16296586.001).
  • [ISSN] 0025-8105
  • [Journal-full-title] Medicinski pregled
  • [ISO-abbreviation] Med. Pregl.
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
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34. Sibio S, Borrini F, Sammartino P, Accarpio F, Biacchi D, Caprio G, Iafrate F, Baccheschi AM, Cornali T, Di Giorgio A: Predominant Brenner tumor combined with struma ovarii containing a papillary microcarcinoma associated with benign peritoneal strumosis: report of a case and histologic features. Endocr Pathol; 2010 Sep;21(3):199-203
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  • [Title] Predominant Brenner tumor combined with struma ovarii containing a papillary microcarcinoma associated with benign peritoneal strumosis: report of a case and histologic features.
  • Brenner tumor and struma ovarii, two uncommon ovarian tumors arising alone or together with dermoid cysts or adenomas, are both rare entities.
  • Few published reports describe coexisting Brenner tumor and malignant struma ovarii.
  • Patients in whom these malignancies coexist only occasionally have peritoneal spreading, strumosis, or a history of thyrotoxicosis.
  • The patient we describe, a 74-year-old woman, presented with a 2 months' history of lower abdominal pain and episodic intestinal subocclusion due to a complex pelvic mass.
  • The mass consisted predominantly of a Brenner tumor associated with struma ovarii containing a single small island of thyroid tissue that had undergone malignant transformation into a well-differentiated papillary carcinoma and also normal thyroid tissue that had spread to the peritoneum.
  • [MeSH-major] Brenner Tumor / pathology. Carcinoma, Papillary / pathology. Neoplasms, Multiple Primary / pathology. Ovarian Neoplasms / pathology. Peritoneal Neoplasms / secondary. Struma Ovarii / secondary

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  • (PMID = 20532676.001).
  • [ISSN] 1559-0097
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Schildhaus HU, Merkelbach-Bruse S, Binot E, Büttner R, Wardelmann E: [Inflammatory fibroid polyp: from Vanek's "submucosal granuloma" to the concept of submucosal mesenchymal neoplasia]. Pathologe; 2010 Mar;31(2):109-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Inflammatory fibroid polyp: from Vanek's "submucosal granuloma" to the concept of submucosal mesenchymal neoplasia].
  • [Transliterated title] Inflammatorischer fibroider Polyp: Von Vaneks "submukösem Granulom" zum Konzept einer submukösen mesenchymalen Neoplasie.
  • IFP represent polypous proliferations of spindle cells in the submucosa and mucosa of the stomach, small bowel and colon with inflammatory infiltration.
  • Therefore, IFP represent true benign mesenchymal tumors of the gastrointestinal tract.
  • [MeSH-minor] Biomarkers, Tumor / genetics. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / pathology. DNA Mutational Analysis. Diagnosis, Differential. Gastric Mucosa / pathology. Gastritis / pathology. Gastrointestinal Stromal Tumors / genetics. Gastrointestinal Stromal Tumors / pathology. Helicobacter Infections / genetics. Helicobacter Infections / pathology. Helicobacter pylori. Humans. Intestinal Mucosa / pathology. Receptor, Platelet-Derived Growth Factor alpha / genetics. Sequence Analysis, DNA. Sequence Analysis, Protein

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  • (PMID = 20107807.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha
  • [Number-of-references] 23
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36. Van Weyenberg SJ, Meijerink MR, Jacobs MA, Van der Peet DL, Van Kuijk C, Mulder CJ, Van Waesberghe JH: MR enteroclysis in the diagnosis of small-bowel neoplasms. Radiology; 2010 Mar;254(3):765-73
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  • [Title] MR enteroclysis in the diagnosis of small-bowel neoplasms.
  • PURPOSE: To evaluate the diagnostic accuracy and interobserver variance of magnetic resonance (MR) enteroclysis in the diagnosis of small-bowel neoplasms, with small-bowel endoscopy, surgery, histopathologic analysis, and follow-up serving as standards of reference, and to identify MR enteroclysis characteristics capable of enabling discrimination between benign and malignant small-bowel neoplasms.
  • Only studies explicitly performed to investigate or exclude the presence of small-bowel neoplasms were included.
  • Tumor characteristics were compared with the Student t test and the Fisher exact test.
  • RESULTS: Readers 1 and 2 interpreted 31 and 33 studies, respectively, as depicting a small-bowel neoplasm and 19 and 17 studies, respectively, as depicting small-bowel malignancy.
  • In 32 patients, the presence of small-bowel neoplasm was confirmed.
  • In 19 of these patients, the neoplasm was malignant.
  • Sensitivity and specificity in the diagnosis of small-bowel neoplasms was 0.91 and 0.95, respectively, for reader 1 and 0.94 and 0.97, respectively, for reader 2; the kappa value was 0.95.
  • CONCLUSION: Eighty-six of 91 studies were correctly interpreted, resulting in an overall diagnostic accuracy of 0.95 for MR enteroclysis in the detection of small-bowel neoplasms.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Intestine, Small. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Contrast Media. Diagnosis, Differential. Endoscopy, Gastrointestinal. False Negative Reactions. False Positive Reactions. Female. Humans. Image Interpretation, Computer-Assisted. Male. Middle Aged. Observer Variation. Reference Standards. Retrospective Studies. Sensitivity and Specificity

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  • [Copyright] (c) RSNA, 2010
  • (PMID = 20177091.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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37. Chiu YC, Lin JW, Changchien CS, Huang CC, Liu SY, Yi LN, Chiu KW, Wu KL, Chen YY, Chou FF, Hu TH: Clinicopathological characteristics and prognosis of patients with small intestinal stromal tumors. J Formos Med Assoc; 2005 Dec;104(12):905-12
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  • [Title] Clinicopathological characteristics and prognosis of patients with small intestinal stromal tumors.
  • BACKGROUND AND PURPOSE: Gastrointestinal stromal tumors (GISTs) involving the small intestine are less common than those involving the stomach, and data on small intestinal stromal tumors (SISTs) are more limited.
  • METHODS: A total of 82 surgically resected and pathologically diagnosed smooth muscle tumors of small bowel in patients treated from January 1986 to December 2000 were included.
  • Immunohistochemical studies were performed on these tumors with antibodies of CD117, CD34, smooth muscle actin (SMA), desmin and S-100.
  • RESULTS: Among the 82 small intestine tumors, 71 were CD117-positive (86.6%) and were classified as SISTs.
  • Survival analysis demonstrated that tumor size < 5 cm (p = 0.021), mitosis number < 5/50 high-power field (p < 0.001), SMA-positive (p = 0.027), non-epithelioid cell type (p = 0.005) and tumor with skeinoid fibers (p = 0.010) predicted longer disease-free survival after operation.
  • Multivariate analysis revealed that mitotic number (p = 0.001), cell morphology (p = 0.031) and tumor size (p = 0.004) were independent prognostic factors.
  • In comparison to GSTs, SISTs exhibited significantly lower rates of CD34, but significantly higher rates of SMA and S-100 immunoreactivity.
  • SMA reactivity is a predictor of benign clinical behavior in SISTs.
  • Tumor mitotic numbers, tumor size, and cell type were independent prognostic factors for patients with SISTs after operation.

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  • (PMID = 16607447.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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38. Ferraretto A, Gravaghi C, Donetti E, Cosentino S, Donida BM, Bedoni M, Lombardi G, Fiorilli A, Tettamanti G: New methodological approach to induce a differentiation phenotype in Caco-2 cells prior to post-confluence stage. Anticancer Res; 2007 Nov-Dec;27(6B):3919-25
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  • RESULTS: Subcultures of Caco-2 cells at pre-confluence, exhibiting progressive acquisition of a more benign differentiation phenotype, were generated.
  • Early passages of Caco-2 cells showed a well-developed brush border and incomplete junctional apparatus; subsequent subcultures yielded cell populations with well-developed junctions similar to those of small intestinal cells.
  • CONCLUSION: These culture conditions represent a new versatile model not only to progressively induce the differentiation program in Caco-2 cells at pre-confluence without changes of culture media, but also to explore mechanistic modes of drug transport and tumor development.

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  • (PMID = 18225551.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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39. Lok KH, Lai L, Yiu HL, Szeto ML, Leung SK: Endosonographic surveillance of small gastrointestinal tumors originating from muscularis propria. J Gastrointestin Liver Dis; 2009 Jun;18(2):177-80
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  • [Title] Endosonographic surveillance of small gastrointestinal tumors originating from muscularis propria.
  • Management for small SMT originating from muscularis propria (MP) is controversial.
  • Patients with small tumor and benign EUS features were offered regular EUS surveillance or surgery if they wished.
  • Forty-nine patients had a small tumor and benign EUS features.
  • The histopathological results were low risk gastrointestinal stromal tumor (GIST) in both patients.
  • Three patients (13.0%) showed interval increase in tumor size.
  • CONCLUSION: It remains unclear whether EUS surveillance for small tumors originating from MP in the upper gastrointestinal tract is useful.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease Progression. Female. Gastric Mucosa / ultrasonography. Humans. Intestinal Mucosa / ultrasonography. Male. Middle Aged. Retrospective Studies. Time Factors. Young Adult

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  • (PMID = 19565047.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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40. Korsisaari N, Kasman IM, Forrest WF, Pal N, Bai W, Fuh G, Peale FV, Smits R, Ferrara N: Inhibition of VEGF-A prevents the angiogenic switch and results in increased survival of Apc+/min mice. Proc Natl Acad Sci U S A; 2007 Jun 19;104(25):10625-30
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  • Anti-VEGF-A monoclonal antibodies, in combination with chemotherapy, result in a survival benefit in patients with metastatic colorectal and non-small cell lung cancer, but little is known regarding the impact of anti-VEGF-A therapy on benign or premalignant tumors.
  • The Apc+/min mice have been widely used as a model recapitulating early intestinal adenoma formation.
  • To investigate whether tumor growth in Apc+/min mice is mediated by VEGF-A-dependent angiogenesis, we used two independent approaches to inhibit VEGF-A: monotherapy with a monoclonal antibody (Mab) targeting VEGF-A and genetic deletion of VEGF-A selectively in intestinal epithelial cells.
  • Short-term (3 or 6 weeks) treatment with anti-VEGF-A Mab G6-31 resulted in a nearly complete suppression of adenoma growth throughout the small intestine.
  • Deletion of VEGF-A in intestinal epithelial cells of Apc+/min mice yielded a significant inhibition of tumor growth, albeit of lesser magnitude than that resulting from Mab G6-31 administration.
  • These results establish that inhibition of VEGF-A signaling is sufficient for tumor growth cessation and confers a long-term survival benefit in an intestinal adenoma model.
  • Therefore, VEGF-A inhibition may be a previously uncharacterized strategy for the prevention of the angiogenic switch and growth in intestinal adenomas.
  • [MeSH-minor] Adenoma / blood supply. Adenoma / genetics. Adenoma / immunology. Adenoma / therapy. Animals. Antibodies, Monoclonal / immunology. Antibodies, Monoclonal / pharmacology. Gene Deletion. In Situ Hybridization. Intestinal Neoplasms / blood supply. Intestinal Neoplasms / genetics. Intestinal Neoplasms / immunology. Intestinal Neoplasms / therapy. Mice. Mice, Inbred C57BL. Signal Transduction / immunology. Survival Analysis. Time Factors

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  • (PMID = 17553957.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Vascular Endothelial Growth Factor A
  • [Other-IDs] NLM/ PMC1888576
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41. Fukumoto A, Tanaka S, Shishido T, Oka S, Chayama K: [Diagnosis and treatment for benign small bowel tumor]. Nihon Rinsho; 2008 Jul;66(7):1305-11
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  • [Title] [Diagnosis and treatment for benign small bowel tumor].
  • Even if small bowel tumors are benign, they need to be treated when they cause symptoms, such as gastrointestinal bleeding or enteric intussusception.
  • It became possible to perform endoscopic treatment for small bowel lesions using DBE.
  • Therefore for preventing surgical operation, it became important to detect small bowel tumors while endoscopic treatment is possible.
  • CE has potential to survey small bowel tumors, especially in patients with polyposis.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Intestine, Small

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  • (PMID = 18616121.001).
  • [ISSN] 0047-1852
  • [Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine
  • [ISO-abbreviation] Nippon Rinsho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 20
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42. Coffin CM, Hornick JL, Zhou H, Fletcher CD: Gardner fibroma: a clinicopathologic and immunohistochemical analysis of 45 patients with 57 fibromas. Am J Surg Pathol; 2007 Mar;31(3):410-6
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  • Gardner fibroma (GAF) is a benign soft tissue lesion with a predilection for childhood and adolescence and an association with familial adenomatous polyposis (FAP) and desmoid type fibromatosis (desmoid).
  • Information about family history, intestinal polyps, colon cancer, and soft tissue tumors was available in 23 patients.
  • The age range at initial diagnosis was 2 months to 36 years.
  • All displayed a bland hypocellular proliferation of haphazardly arranged coarse collagen fibers with a bland hypocellular proliferation of inconspicuous spindle cells, small blood vessels, and a sparse mast cell infiltrate.
  • [MeSH-minor] Adenomatous Polyposis Coli / complications. Adenomatous Polyposis Coli / metabolism. Adenomatous Polyposis Coli / pathology. Adolescent. Adult. Biomarkers, Tumor / metabolism. Cell Nucleus / metabolism. Cell Nucleus / pathology. Child. Child, Preschool. Cyclin D. Cyclins / metabolism. Female. Fibromatosis, Aggressive / complications. Fibromatosis, Aggressive / metabolism. Fibromatosis, Aggressive / pathology. Humans. Immunohistochemistry. Infant. Male. Proto-Oncogene Proteins c-myc / metabolism. beta Catenin / metabolism

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  • (PMID = 17325483.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin D; 0 / Cyclins; 0 / MYC protein, human; 0 / Proto-Oncogene Proteins c-myc; 0 / beta Catenin
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43. Clemente G, Sarno G, Giordano M, De Rose AM, Giovannini I, Vecchio FM, Nuzzo G: Total gastrectomy for type 1 gastric carcinoid: an unusual surgical indication? Minerva Chir; 2007 Oct;62(5):421-4
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  • Gastric carcinoid is a relatively rare neoplasm with peculiar features which differentiate it from the intestinal and pulmonary carcinoid and, obviously, from gastric adenocarcinoma.
  • Gastric carcinoids are divided into three different types: Type 1, associated with gastric atrophy and megaloblastic anemia; Type 2, associated with Zollinger-Ellison syndrome within a type 1 multiple endocrine neoplasia (MEN); and Type 3, sporadic tumor not associated with other lesions, particularly invasive and with poor prognosis.
  • It is generally small, multifocal and located in the gastric fundus, has no tendency for vascular invasion and is associated with a benign course.
  • We report a case of a woman with a type 1 gastric carcinoid in which, for the presence of an extended micro-polyposis of the fundus a total gastrectomy was necessary for treatment.
  • [MeSH-major] Carcinoid Tumor / surgery. Gastrectomy. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery

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  • (PMID = 17947953.001).
  • [ISSN] 0026-4733
  • [Journal-full-title] Minerva chirurgica
  • [ISO-abbreviation] Minerva Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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44. Albores-Saavedra J, Galliani C, Chable-Montero F, Batich K, Henson DE: Mucin-containing Rokitansky-Aschoff sinuses with extracellular mucin deposits simulating mucinous carcinoma of the gallbladder. Am J Surg Pathol; 2009 Nov;33(11):1633-8
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  • Detached fragments of biliary epithelium, small glands, and papillary structures lacking cytologic atypia and mitotic figures were identified in the abundant mucin deposits located in the subserosa of 3 cases.
  • The overlying surface gallbladder epithelium exhibited papillary hyperplasia with focal intestinal metaplasia in 2 patients, one of which had metachromatic leukodystrophy.
  • The lack of reactivity for carcinoembryonic antigen and p53 and the low proliferative activity as measured by MIB-1 labeling index provided additional support to the benign nature of the lesion.
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Cell Proliferation. Child, Preschool. Disease-Free Survival. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mucous Membrane / metabolism. Mucous Membrane / pathology

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  • [CommentIn] Am J Surg Pathol. 2011 Jan;35(1):153-4 [21164300.001]
  • (PMID = 19738458.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins
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45. Baichi MM, Arifuddin RM, Mantry PS: Small-bowel masses found and missed on capsule endoscopy for obscure bleeding. Scand J Gastroenterol; 2007 Sep;42(9):1127-32
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  • [Title] Small-bowel masses found and missed on capsule endoscopy for obscure bleeding.
  • OBJECTIVE: Data on the nature of small-bowel tumors found or missed by capsule endoscopy (CE) are limited.
  • The aim of this study was to review the CE findings in patients with small-bowel tumors presenting as obscure gastrointestinal (GI) bleeding.
  • RESULTS: Ten (3%) confirmed small-bowel masses were found in 9 patients.
  • Benign lesions included inflammatory fibroid polyp (n=1) and lipoma (n=1).
  • Three duodenal masses were missed on a previous EGD; one was missed by CE as well.
  • CE findings led directly to tumor diagnosis in 7 of the 10 cases.
  • CONCLUSIONS: Small-bowel tumors are a rare but serious source of obscure GI bleeding.
  • Mass lesions in the duodenum are particularly elusive and can be missed by both EGD and CE.
  • [MeSH-major] Capsule Endoscopy. Intestinal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Female. Gastrointestinal Hemorrhage / etiology. Humans. Intestine, Small. Male. Middle Aged. Retrospective Studies. Treatment Outcome


46. Simula MP, Cannizzaro R, Marin MD, Pavan A, Toffoli G, Canzonieri V, De Re V: Two-dimensional gel proteome reference map of human small intestine. Proteome Sci; 2009;7:10
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  • [Title] Two-dimensional gel proteome reference map of human small intestine.
  • BACKGROUND: The small intestine is an important human organ that plays a central role in many physiological functions including digestion, absorption, secretion and defense.
  • Alterations in the bowel reduce its capability to absorb nutrients, minerals and fat-soluble vitamins.
  • Adenoma is a benign tumor that has the potential to become cancerous.
  • This approach, may be useful for comparing similar protein samples in different laboratories and for the molecular characterization of intestinal pathologies without recurring to the use of surgical material.
  • CONCLUSION: This study represents to date the first detailed and reproducible 2D protein map of human duodenum.

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  • (PMID = 19298663.001).
  • [ISSN] 1477-5956
  • [Journal-full-title] Proteome science
  • [ISO-abbreviation] Proteome Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2667413
  •  go-up   go-down


47. Kimchi NA, Eliakim R, Suissa A, Scapa E: [The contribution of capsule endoscopy to the diagnosis of small-bowel tumors in cases of obscure overt gastrointestinal bleeding]. Harefuah; 2006 Nov;145(11):811-4, 862, 861
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The contribution of capsule endoscopy to the diagnosis of small-bowel tumors in cases of obscure overt gastrointestinal bleeding].
  • BACKGROUND: The source of obscure bleeding is usually located in the small bowel.
  • GOALS: To review our experience with the diagnosis of small bowel tumors by CE in patients with obscure overt gastrointestinal bleeding.
  • RESULTS: Among 156 patients who underwent CE examination (including 58 patients with obscure overt bleeding), five patients, all of whom presented with melena, were diagnosed as having a small bowel tumor.
  • Three tumors were found in one patient (two ileal carcinoids and one ileal benign stromal tumor).
  • A jejunal benign stromal tumor was diagnosed in two other patients by push enteroscopy.
  • In two patients, three small tumors were detected, beyond the reach of push enteroscopy, but surgical confirmation was not available.
  • CONCLUSIONS: The possibility of finding a small bowel tumor emphasizes the role of capsule endoscopy in patients with obscure overt gastrointestinal bleeding.
  • [MeSH-major] Capsule Endoscopy / methods. Gastrointestinal Hemorrhage / etiology. Intestinal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Female. Humans. Jejunal Neoplasms / diagnosis. Male. Middle Aged. Retrospective Studies

  • MedlinePlus Health Information. consumer health - Gastrointestinal Bleeding.
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  • (PMID = 17183952.001).
  • [ISSN] 0017-7768
  • [Journal-full-title] Harefuah
  • [ISO-abbreviation] Harefuah
  • [Language] heb
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Israel
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48. Reid BJ: Early events during neoplastic progression in Barrett's esophagus. Cancer Biomark; 2010;9(1-6):307-24
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  • Barrett's esophagus is a condition in which the stratified squamous epithelium of the distal esophagus is replaced by specialized intestinal metaplasia.
  • Clinical management of Barrett's esophagus, like many other "premalignant" conditions, is characterized by overdiagnosis of benign early changes that will not cause death or suffering during the lifetime of an individual and underdiagnosis of life-threatening early disease.
  • Recent studies of a number of different types of cancer have revealed much greater genomic complexity than was previously suspected.
  • Specialized intestinal metaplasia has many properties that appear to be protective adaptations to the abnormal environment of gastroesophageal reflux.
  • Small, spatial scale studies have been used to infer the temporal order in which genomic abnormalities develop during neoplastic progression in Barrett's esophagus.
  • These spatial studies have provided the basis for prospective cohort studies of biomarkers, including DNA content abnormalities (tetraploidy, aneuploidy) and a biomarker panel of 9p LOH, 17p LOH and DNA content abnormalities.

  • Genetic Alliance. consumer health - Barrett's Esophagus.
  • MedlinePlus Health Information. consumer health - Esophageal Cancer.
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  • (PMID = 22112482.001).
  • [ISSN] 1875-8592
  • [Journal-full-title] Cancer biomarkers : section A of Disease markers
  • [ISO-abbreviation] Cancer Biomark
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01 CA091955; United States / NCI NIH HHS / CA / P01CA91955
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ NIHMS578448; NLM/ PMC4026269
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49. Sunamak O, Karabicak I, Aydemir I, Aydogan F, Guler E, Cetinkaya S, Korman MU: An intraluminal leiomyoma of the small intestine causing invagination and obstruction: a case report. Mt Sinai J Med; 2006 Dec;73(8):1079-81
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  • [Title] An intraluminal leiomyoma of the small intestine causing invagination and obstruction: a case report.
  • Leiomyomas are mostly of benign character and are rarely seen in the gastrointestinal (GI) system.
  • They represent one subgroup of a group of tumors known as gastrointestinal stromal tumors (GIST).
  • Although rarely seen, they are symptomatic tumors, and they comprise 20-30 percent of all benign GI tumors.
  • Diagnosis is difficult because of their rarity and the absence of specific symptoms.
  • This is a case report of intestinal leiomyoma in a patient who was suffering with GI obstruction for more than 5 months.
  • The tumor was discovered only after the appearance of intestinal obstruction.
  • [MeSH-minor] Aged. Female. Humans. Intestine, Small / pathology

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  • (PMID = 17285198.001).
  • [ISSN] 0027-2507
  • [Journal-full-title] The Mount Sinai journal of medicine, New York
  • [ISO-abbreviation] Mt. Sinai J. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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50. Tsushimi T, Matsui N, Kurazumi H, Takemoto Y, Oka K, Seyama A, Morita T: Laparoscopic resection of an ileal lipoma: Report of a case. Surg Today; 2006;36(11):1007-11
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  • [Title] Laparoscopic resection of an ileal lipoma: Report of a case.
  • Ultrasonography (US) showed a hyperechoic mass in the right lower abdomen, and computed tomography (CT) showed a low-density mass and intestinal invagination.
  • Thus, we made a diagnosis of intestinal lipoma with intussusception and performed laparoscopic partial resection of the ileum, including the tumor.
  • The resected specimen contained a round tumor, 25 x 22 x 20 mm, which was identified as an intestinal lipoma histopathologically.
  • Our experience supports earlier reports that US and CT are effective tools in the diagnosis of bowel lipoma.
  • Laparoscopic surgery is the treatment of choice for benign tumors of the small intestine because it is minimally invasive, with cosmetic, physical, and economic benefits.
  • [MeSH-minor] Anastomosis, Surgical. Female. Follow-Up Studies. Humans. Ileum / surgery. Middle Aged

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  • (PMID = 17072725.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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51. Tamura H, Ohtsuka M, Washiro M, Kimura F, Shimizu H, Yoshidome H, Kato A, Seki N, Miyazaki M: Reg IV expression and clinicopathologic features of gallbladder carcinoma. Hum Pathol; 2009 Dec;40(12):1686-92
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  • Regenerating islet-derived family, member 4 (Reg IV) has been shown to be associated with colorectal carcinogenesis and gastric carcinogenesis through intestinal metaplasia.
  • Immunohistochemically, although only a small part of the epithelium with intestinal metaplasia in 2 of 4 cases with adenomyomatosis showed Reg IV expression, Reg IV was negative in all cases with normal gallbladder (n = 15) and cholelithiasis (n = 13).
  • Expression was more frequently observed in well to moderately differentiated than in poorly differentiated adenocarcinomas and significantly correlated with expression of caudal-related homeobox transcription factor (a candidate for involvement in the induction of intestinal metaplasia).
  • Before surgical resection, 4 (33%) of 12 patients with gallbladder carcinoma had high serum Reg IV levels, whereas Reg IV was never elevated in 12 patients with benign diseases.
  • These results suggest that Reg IV is involved in gallbladder carcinoma carcinogenesis through intestinal metaplasia and is associated with relatively favorable prognosis in patients after surgery.
  • The serum level of Reg IV may be of use or indicative of neoplasia.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Enzyme-Linked Immunosorbent Assay. Gene Expression. Homeodomain Proteins / biosynthesis. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Metaplasia / genetics. Metaplasia / metabolism. Metaplasia / pathology. Neoplasm Staging. Prognosis. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 19716164.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Lectins, C-Type; 0 / REG4 protein, human
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52. Bayle S, Rossi P, Bagneres D, Demoux AL, Ashero A, Dales JP, Vitton V, Frances Y, Granel B: [Ileum inflammatory fibroid polyp revealed by intussusception. About one familial case]. Rev Med Interne; 2005 Mar;26(3):233-7
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  • [Title] [Ileum inflammatory fibroid polyp revealed by intussusception. About one familial case].
  • [Transliterated title] Polype fibro-inflammatoire de l'iléon révélé par une invagination. A propos d'un cas familial.
  • INTRODUCTION: Acute ileum intussusception is a frequent and mostly benign condition in childhood.
  • We report a familial form of benign inflammatory fibroid polyps, revealed by an acute ileum intussusception.
  • EXEGESIS: A 41-year-old man, whose mother had undergone three surgical procedures for acute ileum intussusception associated with inflammatory fibroid polyp, was admitted for a abdominal pain that started three month ago.
  • The patient displayed alteration of the intestinal transit, weight loss and sub-occlusive syndrome.
  • In the emergency room, the abdominal computed tomography-scan revealed an acute intussusception of the last loop of the small intestine, probably caused by a tumor and leading to an occlusive syndrome.
  • CONCLUSION: Inflammatory fibroid polyp is always a benign tumor.
  • It is usually isolated, expressing itself mainly in the form of an acute intussusception when located in the small bowel.

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  • (PMID = 15777585.001).
  • [ISSN] 0248-8663
  • [Journal-full-title] La Revue de medecine interne
  • [ISO-abbreviation] Rev Med Interne
  • [Language] FRE
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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53. Bara T, Bancu S, Bara T Jr, Mureşan M, Bancu L, Azamfirei L, Podeanu D, Mureşan S: [Gastric stromal tumor with liver and subcutaneus metastasis. Case report]. Chirurgia (Bucur); 2009 Sep-Oct;104(5):621-4
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  • [Title] [Gastric stromal tumor with liver and subcutaneus metastasis. Case report].
  • [Transliterated title] Tumoră stromală gastrică cu metastaze hepatice şi subcutanate. Prezentare de caz.
  • The gastrointestinal stromal tumours expand from the undefine mezenchimal cells of the intestinal wall and the origin is in the Cajal interstitial cells.
  • Very importants factors for grading are the tumour localisation, the invasion of serosa or mucosa, the dimensions of tumour and the number of mytosis.
  • We present a case with haemoragic gastric stromal tumour, with small dimensions, which was initially diagnosed as a "benign" tumour.
  • CONCLUSIONS: The gastrointestinals stromal tumours represent a very rare group of digestive tract tumors, with malignant potentially evolution; the first choice of treatment is surgery, with complete ablation of the tumour.

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  • (PMID = 19943565.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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54. Shimura T, Kataoka H, Sasaki M, Kubota E, Shiraki S, Matsusako K, Nakayama Y, Mizoshita T, Mizushima T, Joh T: Rectal inflammatory fibroid polyp resected with endoscopic submucosal dissection. Intern Med; 2008;47(23):2029-31
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  • Inflammatory fibroid polyp (IFP) is a rare benign tumor originating from the submucosa of the gastrointestinal tract.
  • Colonoscopic examination of an asymptomatic 66-year-old man revealed a small submucosal tumor, 3 mm in diameter, in the rectum.
  • [MeSH-major] Endoscopy, Digestive System / methods. Intestinal Polyps / diagnosis. Intestinal Polyps / pathology. Rectal Diseases / diagnosis. Rectal Diseases / pathology. Submucous Plexus / pathology
  • [MeSH-minor] Humans. Inflammation / diagnosis. Inflammation / surgery. Male

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  • (PMID = 19043255.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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55. Lin CY, Chen HY, Jwo SC, Chan SC: Ileal angiomyolipoma as an unusual cause of small-intestinal intussusception. J Gastroenterol; 2005 Feb;40(2):200-3
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  • [Title] Ileal angiomyolipoma as an unusual cause of small-intestinal intussusception.
  • Angiomyolipomas are benign mesenchymal tumors, but those that arise from the small intestine are exceedingly rare.
  • We report on a 48-year-old woman who had an ileal angiomyolipoma, who presented clinically with vague abdominal pain and bloody stool.
  • Small-bowel intussusception was shown on an abdominal computed tomography (CT) scan.
  • We discuss the clinical manifestations and clinicopathological and immunohistochemical findings of this benign tumor which appeared in this rare location.

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  • (PMID = 15770405.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Desmin
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56. Daum O, Hatlova J, Mandys V, Grossmann P, Mukensnabl P, Benes Z, Michal M: Comparison of morphological, immunohistochemical, and molecular genetic features of inflammatory fibroid polyps (Vanek's tumors). Virchows Arch; 2010 May;456(5):491-7
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  • Vanek's tumor (inflammatory fibroid polyp) is a rare benign lesion occurring throughout the digestive tract.
  • Classical Vanek's tumor contains concentric formations of proliferating spindle cells which are CD34 positive.
  • Atypical, inflammatory pseudotumor-like Vanek's tumor lacks concentric formations and is CD34 negative.
  • Recently, mutations in platelet-derived growth factor receptor alpha (PDGFRA) were reported in gastric and small intestinal Vanek's tumors.
  • In this study, KIT exons 9, 11, 13, and 17, PDGFRA exons 12, 14, and 18, and a part of exon 15 BRAF for point mutation V600E were screened in 23 cases of Vanek's tumor, both classical (n = 16) and inflammatory pseudotumor-like (n = 7).
  • Six Vanek's tumors harbored activating mutations in PDGFRA exons 12 (n = 5) and 18 (n = 1) respectively: S566_E571delinsK (n = 1), S566_E571delinsR (n = 4), and D842 del (n = 1).
  • The results of this study suggest that the two morphological patterns of Vanek's tumor more probably represent only variants of one type of tumor than two different lesions.
  • [MeSH-major] Intestinal Diseases / pathology. Leiomyoma / genetics. Leiomyoma / pathology. Polyps / genetics. Polyps / pathology. Receptor, Platelet-Derived Growth Factor alpha / genetics. Stomach Diseases / pathology

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  • (PMID = 20393746.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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57. Otomi Y, Otsuka H, Morita N, Terazawa K, Harada M, Nishitani H: A case of von Recklinghausen's disease with coincident malignant peripheral nerve sheath tumor and gastrointestinal stromal tumor. J Med Invest; 2009 Feb;56(1-2):76-9
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  • [Title] A case of von Recklinghausen's disease with coincident malignant peripheral nerve sheath tumor and gastrointestinal stromal tumor.
  • (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET/CT) was performed to evaluate a left femoral subcutaneous mass in a patient with von Recklinghausen's disease (vRd) that gradually enlarged, causing pain and numbness.
  • Other subcutaneous masses considered benign and neurogenic in nature also showed FDG uptake (SUVmax around 3 or less), but the degree of FDG uptake differed considerably from the left femoral mass.
  • The abdominal mass was resected and confirmed as gastrointestinal stromal tumor (GIST) of the small intestine.
  • Three months later, the left femoral mass was operated on and pathologically diagnosed as a malignant peripheral nerve sheath tumor (MPNST).
  • We present a rare case of a patient with vRd with a MPNST of the left femur and coincidental GIST of the small intestine.
  • [MeSH-major] Bone Neoplasms / complications. Gastrointestinal Stromal Tumors / complications. Intestinal Neoplasms / complications. Nerve Sheath Neoplasms / complications. Osteitis Fibrosa Cystica / complications
  • [MeSH-minor] Femur / radiography. Femur / radionuclide imaging. Fluorodeoxyglucose F18. Humans. Intestine, Small / radiography. Intestine, Small / radionuclide imaging. Male. Middle Aged. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 19262018.001).
  • [ISSN] 1349-6867
  • [Journal-full-title] The journal of medical investigation : JMI
  • [ISO-abbreviation] J. Med. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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58. Emanuel P, Qin L, Harpaz N: Calcifying fibrous tumor of small intestine. Ann Diagn Pathol; 2008 Apr;12(2):138-41
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  • [Title] Calcifying fibrous tumor of small intestine.
  • Calcifying fibrous tumor (CFT) is a rare benign tumor with a predilection for children and young adults that usually arises in the subcutaneous and deep soft tissues, pleura, or peritoneum.
  • Calcifying fibrous tumor of the gastrointestinal tract is exceedingly rare and therefore prone to confusion with other spindle cell lesions more commonly encountered in this location.
  • We describe 4 cases of calcifying fibrous tumor arising in the terminal ileum, one of which caused the heretofore unreported complication of intestinal intussusception, and discuss the differential diagnosis with other common and uncommon spindle cell lesions.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Fibromatosis, Aggressive / diagnosis. Gastrointestinal Stromal Tumors / diagnosis. Humans. Male

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  • (PMID = 18325476.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. Konstantinidis K, Theodoropoulos GE, Spanomihos G, Sambalis G, Vorias M, Georgiou M, Anastassakou K: Laparoscopic-assisted small bowel resection of a leiomyoma causing recurrent obscure gastrointestinal bleeding. J Laparoendosc Adv Surg Tech A; 2005 Aug;15(4):396-9
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  • [Title] Laparoscopic-assisted small bowel resection of a leiomyoma causing recurrent obscure gastrointestinal bleeding.
  • At his last admission, visceral angiography revealed an area of hypervascularity at the initial portion of the jejunum, containing irregular, corkscrew vessels coming from the first jejunal branch of the superior mesenteric artery.
  • A 2.5 cm diameter, smooth, hypervascular tumor was easily visualized on the jejunal wall 10 cm from the ligament of Treitz.
  • The small bowel segment was laparoscopically mobilized and brought through the subumbilical trocar site, which was extended 1 cm.
  • A limited small bowel resection and a stapled anastomosis were easily performed extracorporeally.
  • Histopathologic examination diagnosed a benign gastrointestinal tumor (gastrointestinal stromal tumor, leiomyoma).
  • Laparoscopic identification and mobilization allows a loop of small bowel to be exteriorized through a small incision; the anastomosis can be safely performed extracorporeally.
  • [MeSH-major] Endoscopy, Gastrointestinal. Gastrointestinal Hemorrhage / etiology. Gastrointestinal Hemorrhage / surgery. Intestinal Neoplasms / complications. Intestinal Neoplasms / surgery. Leiomyoma / complications. Leiomyoma / surgery
  • [MeSH-minor] Anastomosis, Surgical. Humans. Intestine, Small. Male. Middle Aged

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  • (PMID = 16108744.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. Schwartz GD, Barkin JS: Small-bowel tumors detected by wireless capsule endoscopy. Dig Dis Sci; 2007 Apr;52(4):1026-30
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  • [Title] Small-bowel tumors detected by wireless capsule endoscopy.
  • Small bowel tumors are difficult to diagnose because of their endoscopic inaccessibility.
  • The purpose of this report is to describe the largest series of patients with small bowel tumors detected by capsule endoscopy.
  • Eighty six patients were derived from the Given Imaging clinical database on a survey of Pillcam SB capsule users who were diagnosed with 87 small bowel tumors, 1 cecal tumor, and 1 gastric tumor.
  • Malignant tumors comprised 61% (54/89) and benign 39% (35/89).
  • Of the 87 reported small bowel tumors, 4 were identified in the duodenum, 43 tumors were identified in the jejunum, 18 tumors were identified in the ileum, and 22 tumors were located in the mid to distal small bowel.
  • The most common benign tumors were GIST, hemangiomas, hamartomas, adenomas, and granulation tissue polyps.
  • Capsule endoscopy is the diagnostic procedure of choice in patients with suspected small bowel tumors.
  • [MeSH-major] Capsule Endoscopy. Endoscopy, Gastrointestinal. Intestinal Neoplasms / diagnosis. Intestine, Small

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  • (PMID = 17380403.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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61. Colombo P, Rahal D, Grizzi F, Quagliuolo V, Roncalli M: Localized intra-abdominal fibromatosis of the small bowel mimicking a gastrointestinal stromal tumor: a case report. World J Gastroenterol; 2005 Sep 7;11(33):5226-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Localized intra-abdominal fibromatosis of the small bowel mimicking a gastrointestinal stromal tumor: a case report.
  • Intra-abdominal fibromatosis (IAF) is a benign mesenchymal lesion that can occur throughout the gastrointestinal tract.
  • Although rare, it is the most common primary tumor of the mesentery and can develop at any age.
  • We describe a rare case of primary IAF involving the mesentery and small bowel which clinically, macroscopically and histologically mimicked malignant gastrointestinal stromal tumor (GIST).
  • This report highlights the fact that benign IAF can be misdiagnosed as a malignant GIST localized in the mesentery or arising from the intestinal wall.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Gastrointestinal Stromal Tumors / diagnosis. Intestinal Neoplasms / diagnosis. Intestine, Small
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16127758.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4320401
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62. Zhang L, Chen YJ, Shang CZ, Zhong F, Zhang HW, Chen JS: [Diagnosis and treatment of primary tumor of small intestine: a report of 58 cases]. Zhonghua Wei Chang Wai Ke Za Zhi; 2007 Jul;10(4):356-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnosis and treatment of primary tumor of small intestine: a report of 58 cases].
  • OBJECTIVE: To summarize the pathological classification, clinical symptom and experience in the diagnosis and treatment of primary tumor of small intestine.
  • METHODS: Data of 58 patients with primary tumor of small intestine pathologically confirmed from Oct.
  • RESULTS: Thirteen patient (22.4%) had primary benign tumors of small intestine and 45 patient (77.6%) had primary malignant tumors of small intestine.
  • The major clinical signs of primary tumor of small intestine included hemorrhage(85%), abdomen pain(19%), abdomen mass and intestine obstruction(16%).
  • CONCLUSIONS: Primary tumors of small intestine are difficult to be diagnosed preoperatively.
  • CT scan, digital subtraction angiography and radionuclide imaging are helpful for the diagnosis.
  • Laparotomy of abdominal cavity is the main choice for those patients with suspicious tumor of small intestine.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / surgery. Intestine, Small / pathology

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  • (PMID = 17659462.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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63. Hornick JL, Fletcher CD: Intestinal perineuriomas: clinicopathologic definition of a new anatomic subset in a series of 10 cases. Am J Surg Pathol; 2005 Jul;29(7):859-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intestinal perineuriomas: clinicopathologic definition of a new anatomic subset in a series of 10 cases.
  • Benign peripheral nerve sheath tumors are uncommon in the gastrointestinal tract, and perineuriomas have not previously been reported to occur at this anatomic location.
  • In this study, we analyzed the clinicopathologic and immunohistochemical features of 10 perineuriomas arising in the intestine.
  • Eight of the lesions were intramucosal perineuriomas presenting as small sessile polyps detected during colonoscopy; 6 of these 8 patients were asymptomatic and undergoing colorectal cancer screening.
  • The remaining 2 cases were submucosal masses, one each located in the colon and jejunum.
  • The colonic submucosal tumor was microscopically well circumscribed, whereas the jejunal perineurioma showed focal infiltration through the muscularis propria into the subserosa.
  • The stroma was collagenous in the colonic tumor and predominantly myxoid in the jejunal tumor.
  • Electron microscopy was performed on the tumor lacking EMA expression, revealing typical features of perineurioma, namely, spindle cells with long bipolar cytoplasmic processes and prominent pinocytotic vesicles, surrounded by discontinuous basal lamina.
  • No tumor recurred.
  • In summary, perineuriomas may arise in the intestine, most often as intramucosal lesions detected as colorectal polyps with distinctive histologic features including entrapment of colonic crypts.
  • [MeSH-major] Intestinal Neoplasms / pathology. Nerve Sheath Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission. Middle Aged. Treatment Outcome

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  • [CommentIn] Am J Surg Pathol. 2006 Oct;30(10):1337-9 [17001168.001]
  • (PMID = 15958849.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 26
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