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1. Jha P, Moosavi C, Fanburg-Smith JC: Giant cell fibroblastoma: an update and addition of 86 new cases from the Armed Forces Institute of Pathology, in honor of Dr. Franz M. Enzinger. Ann Diagn Pathol; 2007 Apr;11(2):81-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • All cases had benign behavior, but almost half recurred.
  • The caveat was mistaking this tumor for a malignancy.
  • They proposed a relationship of this childhood tumor to dermatofibrosarcoma protuberans (DFSP).
  • Most cases were dermal and subcutaneous, 3 purely dermal, and 5 involved superficial skeletal muscle.
  • Two cases of pure GCF recurred as a hybrid tumor with DFSP areas, one of these with hypercellular DFSP.
  • Most cases studied were positive for CD34 (more intense in DFSP than relatively hypocellular GCF areas) and negative for smooth muscle actin, desmin, HMB-45, keratin, and S100 protein.
  • Additional observations of marked perivascular and onionskin-like chronic inflammation and consistent hemorrhage may aid in the diagnosis of this previously well-described tumor.
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / metabolism. Child. Child, Preschool. Female. History, 20th Century. Humans. Infant. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Registries

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  • (PMID = 17349565.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Biography; Historical Article; Journal Article; Portraits
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Personal-name-as-subject] Enzinger FM
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2. Gaeta M, Mazziotti S, Minutoli F, Genitori A, Toscano A, Rodolico C, Blandino A: MR imaging findings of focal myositis: a pseudotumour that may mimic muscle neoplasm. Skeletal Radiol; 2009 Jun;38(6):571-8
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  • [Title] MR imaging findings of focal myositis: a pseudotumour that may mimic muscle neoplasm.
  • RESULTS: Seven of eight lesions were located in the lower extremities, one of eight in the arm; four of eight involved part of a muscle, two of eight diffusely involved a muscle and two of eight showed multifocal involvement of two or more muscles.
  • Dynamic enhancement pattern corresponded to the type usually seen in benign soft tissue lesions.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Muscle Neoplasms / pathology. Muscle, Skeletal / pathology. Myositis / pathology

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  • (PMID = 19255757.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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3. Ward JL, Prieto VG, Joseph A, Chevray P, Kronowitz S, Sturgis EM: Neurothekeoma. Otolaryngol Head Neck Surg; 2005 Jan;132(1):86-9
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  • Most cases were limited to the dermis, but 2 lesions infiltrated subcutaneous tissue and skeletal muscle.
  • CONCLUSION: Neurothekeoma is a benign neoplasm occurring usually in women and commonly in the head and neck.

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  • (PMID = 15632914.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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4. Blacksin MF, White LM, Hameed M, Kandel R, Patterson FR, Benevenia J: Granular cell tumor of the extremity: magnetic resonance imaging characteristics with pathologic correlation. Skeletal Radiol; 2005 Oct;34(10):625-31
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  • [Title] Granular cell tumor of the extremity: magnetic resonance imaging characteristics with pathologic correlation.
  • OBJECTIVE: The purpose of this study is to delineate the magnetic resonance (MR) appearance of a granular cell tumor (GrCT) of the extremity and to correlate the imaging appearance with the microscopic findings.
  • DESIGN AND PATIENTS: A retrospective review of five patients with a histopathologic diagnosis of GrCT and pre-operative MR imaging of the neoplasm was done.
  • RESULTS: The benign subtype of GrCT is usually isointense or brighter than muscle on T1-weighted sequences, round or oval in shape, superficial in location, and 4 cm or less in size.
  • On T2-weighted sequences, benign lesions may demonstrate a high peripheral signal, as well as a central signal intensity that is isointense to muscle or suppressed fat.
  • A significant stromal component in the tumor and, hypothetically, a ribbon-like arrangement of tumor cells may influence the signal intensity demonstrated on the T1 and T2-weighted sequences.
  • CONCLUSION: Benign GrCT has imaging characteristics which may distinguish this tumor from other soft tissue neoplasms, as well as the malignant type of this tumor.
  • [MeSH-major] Foot Diseases / pathology. Granular Cell Tumor / pathology. Hand / pathology. Shoulder / pathology. Soft Tissue Neoplasms / pathology. Thigh / pathology

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  • (PMID = 16003548.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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5. Joyner DE, Damron TA, Aboulafia A, Bokor W, Bastar JD, Randall RL: Heterogeneous expression of melanoma antigen (hMAGE) mRNA in mesenchymal neoplasia. Tissue Antigens; 2006 Jul;68(1):19-27
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  • In this study, hMAGEA2, hMAGEA3, hMAGEA4, and hMAGEC1 mRNA content in 21 benign mesenchymal tumors (representing seven histotypes) and 28 primary sarcomas (10 histotypes) was inventoried using real-time-PCR and then compared against hMAGE mRNA expression in non-sarcomatous malignancies, three cell lines, and muscle. hMAGEA2, hMAGEA3, and hMAGEC1 transcripts were infrequent in mesenchymal tissues in general, whereas hMAGEA4 mRNA was present in 84% of all mesenchymal tumors, 100% of non-sarcomatous tumors, all three cell lines, and in four of five muscle samples.
  • Although hMAGEA4 mRNA was detected in four of five muscle preparations, there was no indication that the mRNA was translated into protein.
  • The presence of hMAGEA4 mRNA in muscle, plus the inconsistent and infrequent occurrence of hMAGEA2, hMAGEA3, and hMAGEC1 mRNA within and among mesenchymal tumor histotypes, makes these four hMAGE antigens unlikely candidates for sarcoma-specific immunotherapy.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Neoplasm Proteins / metabolism. Neoplasms / metabolism. Neoplasms, Connective Tissue / metabolism. Sarcoma / metabolism. Testis / immunology
  • [MeSH-minor] Cell Line. Cell Line, Tumor. Gene Expression. Humans. Male. Melanoma-Specific Antigens. Muscle, Skeletal / metabolism. Neoplasm Metastasis / pathology. RNA, Messenger / metabolism. RNA, Neoplasm / analysis

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  • [ErratumIn] Tissue Antigens. 2006 Aug;68(2):192
  • (PMID = 16774536.001).
  • [ISSN] 0001-2815
  • [Journal-full-title] Tissue antigens
  • [ISO-abbreviation] Tissue Antigens
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / MAGEA1 protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm
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6. Ryś J, Kruczak A, Marczyk E, Skotnicki P, Moskal J, Ambicka A, Harazin-Lechowska A, Wasilewska A, Vogelgesang M, Dyczek S: Primary soft tissue giant cell tumour of the neck. Cytological and histological characteristics of the tumour and differential diagnosis. Pol J Pathol; 2009;60(2):98-104; quiz 105
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  • Giant cell tumour of soft part is a very rare neoplasm.
  • That is why we report a case of primary giant cell tumour of soft part localized in the trapezius muscle of a 19-year-old woman.
  • We present both cytological and histological picture of the neoplasm.
  • [MeSH-major] Giant Cell Tumors / pathology. Head and Neck Neoplasms / pathology. Muscle, Skeletal / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Osteosarcoma / diagnosis. Sarcoma, Synovial / diagnosis. Synovitis, Pigmented Villonodular / diagnosis. Treatment Outcome. Young Adult

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  • (PMID = 19886185.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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7. Dobashi Y, Suzuki S, Sato E, Hamada Y, Yanagawa T, Ooi A: EGFR-dependent and independent activation of Akt/mTOR cascade in bone and soft tissue tumors. Mod Pathol; 2009 Oct;22(10):1328-40
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  • To gain the insight into the involvement of signaling mediated by the mammalian target of rapamycin (mTOR) in the phenotype and biological profiles of tumors and tumor-like lesions of the bone and soft tissue, we analyzed the expression and phosphorylation (activation) of mTOR and its correlation with the status of upstream and downstream modulator proteins Akt, p70S6-kinase (S6K), and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), which we refer to collectively as mTOR cassette proteins.
  • Immunohistochemical analysis of 140 cases showed activation of Akt in 55% (61% in malignant and 27% in benign), and mTOR expression in 61% (66% in malignant and 39% in benign).
  • The preponderance of mTOR activation was found in tumors of peripheral nerve sheath (malignant peripheral nerve sheath tumor and schwannoma), skeletal muscle origin (rhabdomyosarcoma), and in those exhibiting epithelial nature (chordoma and synovial sarcoma).
  • We conclude that mTOR-mediated signaling proteins function not only in the proliferation of the tumor cells, but also in the differentiation and/or maintenance of morphological phenotypes in tumors of rhabdomyoblastic and nerve sheath cell origin.
  • [MeSH-minor] Cell Proliferation. Enzyme Activation. Humans. Immunoblotting. Immunohistochemistry. Mutation. Neoplasm Staging. Phosphorylation. Prognosis. TOR Serine-Threonine Kinases

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  • (PMID = 19648884.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / EIF4EBP1 protein, human; 0 / Phosphoproteins; EC 2.7.- / Protein Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.1 / Ribosomal Protein S6 Kinases, 70-kDa
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8. Pichi B, Manciocco V, Marchesi P, Pellini R, Ruscito P, Vidiri A, Covello R, Spriano G: Rhabdomyoma of the parapharyngeal space presenting with dysphagia. Dysphagia; 2008 Jun;23(2):202-4
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  • Rhabdomyoma is an exceedingly rare soft tissue benign tumor of skeletal muscle origin classified into cardiac and extracardiac types based on location.
  • Adult rhabdomyomas are rare, but morphologically characteristic, benign mesenchymal tumors with mature skeletal muscle differentiation that in 90% of cases arise in the head and neck region, mainly in the mucosa of the oropharynx, nasopharynx, and larynx, from the branchial musculature of third and fourth branchial arches.

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  • (PMID = 17965913.001).
  • [ISSN] 0179-051X
  • [Journal-full-title] Dysphagia
  • [ISO-abbreviation] Dysphagia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Ruiz Liso JM, Ruiz García J, Pardo López ML, Vaillo Vinagre A, Gutiérrez Martín A, Marrón Martínez MC, García Pérez MA: [Inflammatory malignant fibrous histiocytoma of the spermatic cord infiltrating an inguinal leiomyoma. Case report with conceptual and bibliographic reviews]. Arch Esp Urol; 2008 May;61(4):485-98
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  • The accomplishment of an intraoperatory biopsy is essential in this location, since it is even difficult to know preoperatively, if a lesion is benign or malignant.
  • Their immunophenotype allowed us to diagnose it not only as leiomyoma (myogenic markers were positive -non skeletal muscle-), but also to observe the infiltration by the FHM.
  • [MeSH-minor] Aged, 80 and over. Humans. Immunophenotyping. Inflammation / pathology. Male. Neoplasm Invasiveness

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  • (PMID = 18592766.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 84
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10. Cyran CC, Fu Y, Raatschen HJ, Rogut V, Chaopathomkul B, Shames DM, Wendland MF, Yeh BM, Brasch RC: New macromolecular polymeric MRI contrast agents for application in the differentiation of cancer from benign soft tissues. J Magn Reson Imaging; 2008 Mar;27(3):581-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] New macromolecular polymeric MRI contrast agents for application in the differentiation of cancer from benign soft tissues.
  • 100 cm(3)) and tumor fractional plasma volumes (%) based on a two-compartment kinetic model were performed for skeletal muscle and tumors.
  • 100 cm(3)) in normal soft tissue microvessels allowing successful differentiation (P < 0.05) of cancers from normal muscle.
  • PEG(12,000)-Gen4-(Gd-DOTA) leaked in tumors and in normal muscle (K(PS) = 51 +/- 26 and K(PS) = 21 +/- 18 microL/min .
  • The apparent threshold in effective molecular weight for a clear differentiation of cancer from normal muscle with no measurable leak in the muscle is between 194 and 323 kDa.
  • [MeSH-minor] Animals. Breast Neoplasms / diagnosis. Endothelium, Vascular. Female. Humans. Neoplasm Transplantation. Rats. Rats, Nude. Transplantation, Heterologous

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  • (PMID = 18219614.001).
  • [ISSN] 1053-1807
  • [Journal-full-title] Journal of magnetic resonance imaging : JMRI
  • [ISO-abbreviation] J Magn Reson Imaging
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 082923; United States / NCI NIH HHS / CA / R01 CA 103850
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Heterocyclic Compounds; 0 / Organometallic Compounds; 92923-44-9 / gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate; AU0V1LM3JT / Gadolinium
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11. Chiang ER, Chen TH: Multiple glomus tumors in gastrocnemius muscle: a case report. Arch Orthop Trauma Surg; 2008 Jan;128(1):29-31
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  • [Title] Multiple glomus tumors in gastrocnemius muscle: a case report.
  • Glomus tumors are rare benign tumors that account 1-5% of soft tissue tumors of the hand.
  • We describe an unusual case of recurrent glomus tumor located in lower leg.
  • [MeSH-major] Glomus Tumor / diagnosis. Muscle Neoplasms / diagnosis. Muscle, Skeletal. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 17624538.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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12. Mandal RV, Duncan LM, Austen WG Jr, Nielsen GP: Infiltrating intramuscular spindle cell lipoma of the face. J Cutan Pathol; 2009 Oct;36 Suppl 1:70-3
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  • Spindle cell lipoma is a benign lipomatous tumor, which usually arises on the back of the neck, shoulder or upper back of males in the third to seventh decade of life.
  • Histologically, a proliferation of mature adipocytes, ropey collagen fibers and spindle cells within a myxoid stroma was present in the subcutaneous tissue and infiltrated between skeletal muscle fibers.
  • [MeSH-major] Lipoma / pathology. Neoplasm Recurrence, Local / pathology. Nose Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19187113.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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13. Micheli A, Trapani S, Brizzi I, Campanacci D, Resti M, de Martino M: Myositis ossificans circumscripta: a paediatric case and review of the literature. Eur J Pediatr; 2009 May;168(5):523-9
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  • Myositis ossificans circumscripta (MOC), characterised by non-neoplastic heterotopic bone formation in soft tissue and skeletal muscle, is rare in children.
  • At onset, it is difficult to distinguish MOC from a musculoskeletal infection or neoplasm, particularly in absence of trauma, and a biopsy is frequently required.
  • After incisional biopsy, the histopathological examination found immature osteoblasts inside striated muscle fibres, as well as proliferating fibroblasts, which are all compatible with MOC, thereby ruling out infection or malignancy.
  • Our case study confirms the good prognosis of MOC and underlines how this benign condition should be considered in children presenting a tender and painful soft-tissue swelling.
  • [MeSH-minor] Anti-Bacterial Agents / therapeutic use. Anti-Inflammatory Agents / therapeutic use. Biopsy. Child. Diagnosis, Differential. Humans. Lymphadenitis / diagnosis. Magnetic Resonance Imaging. Male. Muscle, Skeletal / metabolism. Muscle, Skeletal / pathology. Necrosis / pathology. Osteoblasts / metabolism. Sarcoma / pathology. Soft Tissue Injuries / diagnosis. Soft Tissue Injuries / metabolism. Soft Tissue Injuries / pathology

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  • (PMID = 19130083.001).
  • [ISSN] 1432-1076
  • [Journal-full-title] European journal of pediatrics
  • [ISO-abbreviation] Eur. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Anti-Inflammatory Agents
  • [Number-of-references] 35
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14. Falavigna A, Righesso O, Volquind D, Teles AR: Intramuscular myxoma of the cervical paraspinal muscle. Eur Spine J; 2009 Jul;18 Suppl 2:245-9
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  • [Title] Intramuscular myxoma of the cervical paraspinal muscle.
  • Myxoma is a neoplasm of mesenchymal origin composed of undifferentiated stellate cells in a myxoid stroma.
  • This tumor can develop in a variety of locations.
  • Myxomas that arise from skeletal muscles are called intramuscular myxomas.
  • They usually occur in large skeletal muscles.
  • Only ten cases of these benign tumors involving the neck muscles were reported in literature.
  • Tumor total removal was performed through normal muscle margins and the vertebral periosteum was scraped.
  • The tumor was encapsulated, lobulated with a gray-white appearance.
  • Despite its benign characteristics, local recurrence was reported after subtotal resection.
  • Tumor total removal should be the goal of surgery.
  • [MeSH-major] Cervical Vertebrae. Muscle Neoplasms / diagnosis. Muscle, Skeletal. Myxoma / diagnosis

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  • (PMID = 19301043.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 20
  • [Other-IDs] NLM/ PMC2899565
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15. Nikitakis NG, Argyris P, Sklavounou A, Papadimitriou JC: Oral myoepithelioma of soft tissue origin: report of a new case and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Nov;110(5):e48-51
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  • Oral myoepithelioma of soft tissue origin, an entity distinct from myoepithelioma of salivary glands, constitutes an extremely rare benign neoplasm, with only 1 previously published case, affecting the tongue of a 22-year-old woman.
  • Ectomesenchymal chondromyxoid tumour (ECT) also is a very rare benign neoplasm of the oral cavity that has a strong predilection for the anterior dorsum of the tongue.
  • [MeSH-minor] Actins / analysis. Antigens, CD57 / analysis. Cell Nucleus / ultrastructure. Chromatin / ultrastructure. Cytoplasm / ultrastructure. Desmin / analysis. Diagnosis, Differential. Glial Fibrillary Acidic Protein / analysis. Humans. Male. Middle Aged. Mouth Mucosa / pathology. Muscle, Skeletal / pathology. Neoplasms, Complex and Mixed / diagnosis. S100 Proteins / analysis. Vimentin / analysis

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  • [Copyright] Copyright © 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20955943.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD57; 0 / Chromatin; 0 / Desmin; 0 / Glial Fibrillary Acidic Protein; 0 / S100 Proteins; 0 / Vimentin
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16. Hornick JL, Fletcher CD: Cellular neurothekeoma: detailed characterization in a series of 133 cases. Am J Surg Pathol; 2007 Mar;31(3):329-40
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  • Cellular neurothekeomas are distinctive benign cutaneous tumors of uncertain histogenesis.
  • Mean tumor size was 1.1 cm (range: 0.3 to 6 cm; 90% <2 cm).
  • In 30% of cases, neurothekeoma was suggested by the referring pathologist; the most common other diagnoses offered were plexiform fibrohistiocytic tumor, benign fibrous histiocytoma, and a low-grade sarcoma.
  • Histologically, most cases were poorly marginated; 33 (25%) infiltrated fat, and 10 (8%) entrapped skeletal muscle (all but 1 situated on the face).
  • All tumors were reactive for NKI-C3, 110/123 (89%) expressed neuron-specific enolase, 73/127 (57%) showed at least focal staining for smooth muscle actin, and only 1 was focally desmin positive.
  • Ten tumors recurred locally (7 situated on the face), after a mean of 18 months; tumor had been marginally excised or had involved excision margins in all cases with available information.
  • There is no good evidence that these lesions show nerve sheath differentiation and the nomenclature will likely change when the tumor cell lineage is better defined.
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Child. Child, Preschool. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Immunohistochemistry. Infant. Male. Middle Aged. Mitosis. Neoplasm Recurrence, Local. Sarcoma / diagnosis

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  • (PMID = 17325474.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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17. Monson E, Vancourt R, Dawson J: Myxoinflammatory fibroblastic sarcoma: a case report and review of the literature. J Foot Ankle Surg; 2010 Jan-Feb;49(1):86.e1-3
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  • The majority of soft tissue masses seen in the lower extremity are benign tumors caused by degenerative, reactive, or inflammatory processes.
  • This is a rare tumor that predominately involves the distal extremities.
  • It often presents as a painless mass within the subcutaneous tissue and can easily be confused with benign lesions.
  • A high rate of local recurrence means patients must be followed up closely after resection of the tumor.
  • [MeSH-minor] Amputation. Humans. Leg. Male. Middle Aged. Muscle, Skeletal / pathology. Neoplasm Invasiveness. Neoplasm Recurrence, Local / surgery. Postoperative Complications. Surgical Flaps

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  • [Copyright] Copyright 2010 American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20123295.001).
  • [ISSN] 1542-2224
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 8
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18. Pinto Blázquez J, Velasco Alonso J, Menendez CL, Alonso de la Campa J, Astudillo Gonzalez A: Fine needle aspiration cytology of focal myositis: a case report. Acta Cytol; 2005 Nov-Dec;49(6):653-5
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  • BACKGROUND: Focal myositis is an unusual inflammatwy lesion of the skeletal muscle first described by Heffizer.
  • It is a benign condition and usually involves the muscles of the limbs.
  • Nuclear magnetic resonance of the leg showed a mass in the tibial muscle; the presumptive diagnosis was sarcoma of the muscle.
  • Smears showed inflammatory cells, skeletal muscle fibers with degenerative and regenerative changes, and fibrous tissue, suggesting a diagnosis of focal myositis.
  • An incisional muscle biopsy was performed, confirming the diagnosis.
  • CONCLUSION: Focal myositis should always he considered when aspirating muscle masses because it is a clinical mimic of a neoplasm.
  • [MeSH-minor] Biopsy, Fine-Needle / methods. Diagnosis, Differential. Humans. Male. Middle Aged. Muscle Fibers, Skeletal / pathology. Sarcoma / diagnosis. Sensitivity and Specificity

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  • (PMID = 16450907.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Lokeshwar VB, Cerwinka WH, Lokeshwar BL: HYAL1 hyaluronidase: a molecular determinant of bladder tumor growth and invasion. Cancer Res; 2005 Mar 15;65(6):2243-50
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  • [Title] HYAL1 hyaluronidase: a molecular determinant of bladder tumor growth and invasion.
  • Hyaluronic acid promotes tumor progression; however, the functions of hyaluronidase in cancer are largely unknown.
  • Whereas HYAL1-S and vector tumors infiltrated skeletal muscle and blood vessels, HYAL1-AS tumors resembled benign neoplasia.
  • HYAL1-S and vector tumors expressed significantly higher amounts of HYAL1 (in tumor cells) and hyaluronic acid (in tumor-associated stroma) than HYAL1-AS tumors.
  • These results show that HYAL1 expression in bladder cancer cells regulates tumor growth and progression and therefore serves as a marker for high-grade bladder cancer.
  • [MeSH-minor] Apoptosis / physiology. Cell Cycle / physiology. Cell Growth Processes / physiology. Cell Line, Tumor. Extracellular Matrix / metabolism. Humans. Hyaluronic Acid / metabolism. Neoplasm Invasiveness. Neoplasm Transplantation. Neovascularization, Pathologic / enzymology. Neovascularization, Pathologic / pathology. Transfection. Transplantation, Heterologous

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  • (PMID = 15781637.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA 072821-06A2
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 9004-61-9 / Hyaluronic Acid; EC 3.2.1.35 / Hyaluronoglucosaminidase
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20. Kim K, Velez I, Kaltman SI, Lopez E, Stern D: Odontogenic carcinoma differentiation into rhabdomyosarcoma: report of a rare case. Quintessence Int; 2009 Nov-Dec;40(10):837-42
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  • To the authors' knowledge, this is the first reported case of an odontogenic carcinoma with documented skeletal muscle differentiation (rhabdomyosarcoma).
  • The histology and clinical features of this aggressive odontogenic neoplasm are described.
  • Within the English-language literature, only 2 cases are reported of an odontogenic tumor with muscle differentiation: a benign odontogenic tumor (ameloblastoma) with differentiation into a rhabdomyosarcoma and an odontogenic sarcoma with smooth-muscle differentiation.

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  • (PMID = 19898715.001).
  • [ISSN] 1936-7163
  • [Journal-full-title] Quintessence international (Berlin, Germany : 1985)
  • [ISO-abbreviation] Quintessence Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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21. Mete O, Rotstein L, Asa SL: Controversies in thyroid pathology: thyroid capsule invasion and extrathyroidal extension. Ann Surg Oncol; 2010 Feb;17(2):386-91
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  • Controversies surrounding diagnostic criteria that distinguish benign from malignant thyroid follicular lesions have been brought to the attention of this community.
  • Moreover, the presence of adipose tissue within the thyroid gland and its pseudocapsule implies that thyroid tumor within fat tissue cannot be accepted as a criterion of ETE by that thyroid carcinoma.
  • While invasion of skeletal muscle is a more reliable feature of ETE, at the isthmus, these fibers can be normally present within the gland, and this criterion does not have value.
  • [MeSH-minor] Humans. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Thyroid Gland / anatomy & histology

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  • (PMID = 19949881.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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22. Lax S: [Mesenchymal uterine tumors. Stromal tumors and other rare mesenchymal neoplasms]. Pathologe; 2009 Jul;30(4):284-91
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  • There is no smooth or striated muscle differentiation.
  • Adenosarcomas are mixed neoplasms with a low grade stromal sarcoma component containing benign glands, which are surrounded by condensed neoplastic stroma.
  • [MeSH-minor] Arterioles / pathology. Cell Differentiation. Cell Nucleus / pathology. Cytoplasm / pathology. Diagnosis, Differential. Female. Humans. Muscle, Skeletal / pathology. Muscle, Smooth / pathology. Neoplasm Invasiveness. Neoplasm Metastasis. Sarcoma / pathology. Sex Cord-Gonadal Stromal Tumors / pathology. Uterus / pathology

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  • (PMID = 19495764.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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23. Shelekhova K, Kazakov DV, Michal M: Infiltrating retiform perineurioma: a case report. Ann Diagn Pathol; 2005 Oct;9(5):293-4
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  • Retiform perineurioma is a rare distinct histologic subtype of benign soft tissue perineurioma.
  • We report 1 case of retiform perineurioma with a superficial invasion of the adjacent skeletal muscle.
  • The patient was a 34-year-old woman with a neoplasm located between the deltoid muscle and the biceps.
  • Histologically, the tumor was nonencapsulated, composed exclusively of perineurial cells without cytologic and tissue atypia.
  • There were focal areas in which the neoplastic cells infiltrated the muscle tissue, widely separating the bundles.
  • [MeSH-minor] Adult. Female. Humans. Muscle, Skeletal / pathology

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  • (PMID = 16198959.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Hausbrandt PA, Leithner A, Beham A, Bodo K, Raith J, Windhager R: A rare case of infantile myofibromatosis and review of literature. J Pediatr Orthop B; 2010 Jan;19(1):122-6
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  • Infantile myofibromatosis is a rare benign tumor-disease (1/400,000).
  • Radiographic films and ultrasound examination presented a pretibial soft-tissue tumor mass with calcifications and two osteolytic lesions with a sclerotic rim.
  • A skeletal survey showed more osteolytic lesions, but the magnetic resonance imaging showed no more soft-tissue lesions.
  • Infantile myofibromatosis is a very rare benign tumor-disease.
  • Histopathologically, cells characteristically appear as spindle-shaped fibroblast cells with pale pink cytoplasm and elongated nuclei and the immunophenotype is defined with a positive reaction on smooth-muscle antigen vimentin and the muscle-specific antigen HHF-35.
  • However, a thorough examination has to be carried out to exclude lesion in other organs like gastro-intestinal or cardio-pulmonary nodular tumor masses.
  • [MeSH-minor] Calcinosis / pathology. Calcinosis / physiopathology. Diagnosis, Differential. Follow-Up Studies. Frozen Sections. Histiocytosis, Langerhans-Cell / diagnosis. Humans. Infant. Male. Neoplasm Regression, Spontaneous


25. Premalata CS, Kumar RV, Saleem KM, Fathima LJ, Das K: Fetal rhabdomyoma of the lower extremity. Pediatr Blood Cancer; 2009 Jul;52(7):881-3
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  • Fetal rhabdomyoma is a benign tumor of the skeletal muscle, showing varying degrees of skeletal muscle maturation.

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19165887.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Fernández JM, Medlich MA, López LH, Loredo CF, Luque LC: Fetal intermediate rhabdomyoma of the lip: case report. J Clin Pediatr Dent; 2005;29(2):179-80
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  • Fetal rhabdomyoma is a rare benign neoplasm of skeletal muscle that must be distinguished histologically from various malignant lesions, including rhabdomyosarcoma.

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  • (PMID = 15719926.001).
  • [ISSN] 1053-4628
  • [Journal-full-title] The Journal of clinical pediatric dentistry
  • [ISO-abbreviation] J Clin Pediatr Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Zolota V, Tzelepi V, Charoulis N, Apostolakis E, Dougenis D: Mediastinal rhabdomyoma: case report and review of the literature. Virchows Arch; 2006 Jul;449(1):124-8
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  • Rhabdomyomas are benign tumors in which at least some cells are differentiated as skeletal muscle cells with cytoplasmic cross-striations.
  • Extracardiac adult rhabdomyoma is an extremely uncommon benign neoplasm that usually involves the head and neck region.
  • [MeSH-minor] Actins / analysis. Aged. Biomarkers, Tumor / analysis. Desmin / analysis. Disease-Free Survival. Female. Humans. Immunohistochemistry. Myoglobin / analysis. Radiography, Thoracic. Treatment Outcome

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  • [Cites] Am J Surg Pathol. 1992 Jul;16(7):721-8 [1530111.001]
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  • (PMID = 16636850.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Desmin; 0 / Myoglobin
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28. Sheridan T, Herawi M, Epstein JI, Illei PB: The role of P501S and PSA in the diagnosis of metastatic adenocarcinoma of the prostate. Am J Surg Pathol; 2007 Sep;31(9):1351-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It is expressed in both benign and neoplastic prostate tissues, but not in any other normal or malignant tissue examined to date.
  • The tissue microarray contains 78 cases of metastatic prostatic adenocarcinoma, 20 cases of primary prostatic adenocarcinoma, and 20 cases of benign prostate tissue from the peripheral zone as well as samples of benign brain, pancreas, kidney, thyroid, testis, skeletal muscle, and fibroconnective tissue.
  • RESULTS: Similar staining (intensity and extent) was identified for both markers in the majority of metastatic tumors (11 distant sites, 42 pelvic lymph nodes), in all 20 primary tumors and in all benign prostate and nonprostate tissues.
  • [MeSH-minor] Cell Differentiation. Golgi Apparatus / chemistry. Humans. Immunohistochemistry. Lymph Nodes / chemistry. Lymph Nodes / immunology. Male. Neoplasm Staging. Predictive Value of Tests. Reproducibility of Results. Sensitivity and Specificity. Tissue Array Analysis

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  • (PMID = 17721190.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P50 CA58236
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / prostein; EC 3.4.21.77 / Prostate-Specific Antigen
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29. Juhlin J, Eiholm S: [Rhabdomyoma in the head and neck region]. Ugeskr Laeger; 2009 Mar 30;171(14):1194
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Extracardiac rhabdomyoma is an extremely uncommon benign neoplasm with skeletal muscle differentiation which usually involves the head and neck region.

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  • (PMID = 19338741.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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30. Lemos MM, Karlen J, Tani E: Fine-needle aspiration cytology of angiomatoid malignant fibrous histiocytoma. Diagn Cytopathol; 2005 Aug;33(2):116-21
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  • Angiomatoid malignant fibrous histiocytoma (AMFH) is a rare, low-grade malignant mesenchymal neoplasm that affects mostly the extremities of children and young adults.
  • The tumor cells showed mild to moderate anisocariosis, often with nucleolus and vast, fragile cytoplasm.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Muscle Neoplasms / pathology
  • [MeSH-minor] Adolescent. Biopsy, Fine-Needle. Cell Differentiation. Cell Nucleus / metabolism. Cell Nucleus / pathology. Child, Preschool. Female. Fibroblasts / metabolism. Fibroblasts / pathology. Humans. Myoblasts, Skeletal / metabolism. Myoblasts, Skeletal / pathology

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 16007669.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Patsiaoura K, Anagnostou E, Benis N: Intramuscular myxoma of the nasal vestibule. Auris Nasus Larynx; 2010 Feb;37(1):100-2
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  • Intramuscular myxoma is an uncommon benign soft tissue neoplasm and a distinct histopathological entity within the heterogeneous group of myxomas.
  • The tumor was surgically removed and the patient is free of recurrence or complications 8 months after treatment.
  • To the very best of our knowledge, there is no report of this neoplasm located within the nasal and oral mimetic muscles.
  • [MeSH-major] Muscle, Skeletal / pathology. Myxoma / pathology. Paranasal Sinus Neoplasms / pathology

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  • [Copyright] Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19414229.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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32. Watanabe H, Ishida Y, Nagashima K, Makino T, Norisugi O, Shimizu T: Desmoplastic fibroblastoma (collagenous fibroma). J Dermatol; 2008 Feb;35(2):93-7
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  • Desmoplastic fibroblastoma (DF) is a rare fibrotic tumor that has a wide anatomic distribution and it can appear in deep sections of the subcutis, in fascia, in aponeurosis or in skeletal muscles.
  • The entrapment of fat and muscle tissues was focally identified at the edges of the tumor.
  • The stellate and multinucleated cells in the lesion were strongly positive for vimentin but negative for cytokeratin, smooth muscle actin, desmin, S-100, CD34, factor XIIIa, and CD68.
  • These findings suggest that the stellate and multinucleated cells in the lesion were of fibroblastic origin and this neoplasm was pathologically benign.

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  • (PMID = 18271804.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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33. O'Callaghan MG, House M, Ebay S, Bhadelia R: Rhabdomyoma of the head and neck demonstrated by prenatal magnetic resonance imaging. J Comput Assist Tomogr; 2005 Jan-Feb;29(1):130-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This benign tumor of skeletal muscle is uncommon and should not be confused with its malignant counterpart-rhabdomyosarcoma.
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Gestational Age. Humans. Infant, Newborn. Neoplasm Recurrence, Local / pathology. Pregnancy. Ultrasonography, Prenatal


34. Ye H, Walsh PC, Epstein JI: Skeletal muscle involvement by limited Gleason score 6 adenocarcinoma of the prostate on needle biopsy is not associated with adverse findings at radical prostatectomy. J Urol; 2010 Dec;184(6):2308-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Skeletal muscle involvement by limited Gleason score 6 adenocarcinoma of the prostate on needle biopsy is not associated with adverse findings at radical prostatectomy.
  • PURPOSE: Skeletal muscle involvement by prostate cancer is considered to be ambiguous for extraprostatic extension when it is found at the apex, where benign prostatic glands naturally blend with the skeletal muscle of the rhabdosphincter.
  • We investigated the significance of skeletal muscle involvement by cancer in needle biopsies in predicting adverse outcomes at radical prostatectomy.
  • MATERIALS AND METHODS: From 2000 to 2009, we retrospectively identified 40 cases with Gleason score 6 adenocarcinoma involving up to 20% of 1 core, with skeletal muscle involvement.
  • Outcomes of radical prostatectomy were compared with a control group of 82 cases with the same parameters without skeletal muscle involvement from the same period.
  • No statistically significant differences were found between cases with or without skeletal muscle involvement on needle biopsy.
  • CONCLUSIONS: Limited cancer involvement of skeletal muscle in biopsy specimens should not be used as a contraindication for radical prostatectomy for otherwise resectable prostate cancer as most patients have organ confined disease and negative margins.
  • [MeSH-major] Adenocarcinoma / pathology. Muscle Neoplasms / pathology. Prostatectomy. Prostatic Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biopsy, Needle. Humans. Male. Middle Aged. Neoplasm Invasiveness. Retrospective Studies

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  • [Copyright] Copyright © 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20952012.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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35. Bekler H, Gokce A, Beyzadeoglu T: Chondroid syringoma of the hand: a rare localization. Handchir Mikrochir Plast Chir; 2007 Dec;39(6):430-2
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  • Chondroid syringoma is a rare benign neoplasm of the sweat glands that usually occurs in the head and neck region.
  • We describe a 18-year-old male patient with a benign chondroid syringoma that occurred at an unusual site, leading to compression symptoms of the ulnar nerve causing symptoms at the hypothenar region of the right hand.
  • Although it is a rare tumor at an unusual site, it should be included in the differential diagnosis of the hand tumors.
  • [MeSH-minor] Adolescent. Biopsy. Humans. Image Enhancement. Magnetic Resonance Imaging. Male. Muscle, Skeletal / pathology. Neoplasm Invasiveness

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  • (PMID = 18058676.001).
  • [ISSN] 0722-1819
  • [Journal-full-title] Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der Peripheren Nerven und Gefässe : Organ der Vereinigung der Deutschen Plastischen Chirurgen
  • [ISO-abbreviation] Handchir Mikrochir Plast Chir
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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36. Cymet-Ramírez J, Martínez-Flores LM, Villalobos Garduño FE: [Lipoblastoma. A case report]. Acta Ortop Mex; 2007 May-Jun;21(3):151-3
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  • Lipoblastoma is an rare benign tumors of infancy of fetal adipose tissue, that usually affect infants and children less than 3 years of age.
  • The tumor was completely excised surgically.
  • [MeSH-minor] Child, Preschool. Humans. Incidental Findings. Magnetic Resonance Imaging. Male. Muscle, Skeletal / pathology. Neoplasm Invasiveness

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  • (PMID = 17937179.001).
  • [ISSN] 2306-4102
  • [Journal-full-title] Acta ortopédica mexicana
  • [ISO-abbreviation] Acta Ortop Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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37. Chi AC, Barnes JD, Budnick S, Agresta SV, Neville B: Rhabdomyosarcoma of the maxillary gingiva. J Periodontol; 2007 Sep;78(9):1839-45
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  • BACKGROUND: Rhabdomyosarcoma is a malignant neoplasm of primitive mesenchyme exhibiting skeletal muscle differentiation.
  • Many of the tumor cells exhibited abundant eosinophilic cytoplasm.
  • Immunohistochemical stains showed the tumor cells to be positive for desmin, myogenin, and myogenic differentiation 1 (MyoD1).
  • Pain is a variable presenting symptom, and early lesions may be mistaken for benign neoplastic, inflammatory, or infectious processes.

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  • (PMID = 17760557.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 51
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38. Vargas SO, Korpershoek E, Kozakewich HP, de Krijger RR, Fletcher JA, Perez-Atayde AR: Cytogenetic and p53 profiles in congenital cystic adenomatoid malformation: insights into its relationship with pleuropulmonary blastoma. Pediatr Dev Pathol; 2006 May-Jun;9(3):190-5
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  • Congenital cystic adenomatoid malformation (CCAM), a developmental anomaly of lung, shares many features with the pediatric tumor pleuropulmonary blastoma (PPB).
  • Both may show benign epithelium-lined cysts and mesenchymal proliferation, often with skeletal muscle differentiation.
  • [MeSH-major] Cystic Adenomatoid Malformation of Lung, Congenital / genetics. Cystic Adenomatoid Malformation of Lung, Congenital / metabolism. Lung Neoplasms / genetics. Lung Neoplasms / metabolism. Pulmonary Blastoma / genetics. Pulmonary Blastoma / metabolism. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Child, Preschool. Cytogenetics. DNA, Neoplasm / analysis. DNA, Neoplasm / isolation & purification. Female. Humans. Immunohistochemistry. Infant. Karyotyping. Male. Polymorphism, Single-Stranded Conformational. Prospective Studies

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  • (PMID = 16944975.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Tumor Suppressor Protein p53
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39. Østergaard JR, Smith T, Stausbøl-Grøn B: Intraneural perineurioma of the sciatic nerve in early childhood. Pediatr Neurol; 2009 Jul;41(1):68-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Intraneural perineurioma is an uncommon benign neoplasm characterized by focal perineural cell proliferation.
  • [MeSH-minor] Child, Preschool. Diagnosis, Differential. Electromyography. Humans. Magnetic Resonance Imaging. Male. Muscle, Skeletal / pathology. Muscle, Skeletal / physiopathology. Pelvis / pathology. Peroneal Neuropathies / diagnosis

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  • (PMID = 19520281.001).
  • [ISSN] 1873-5150
  • [Journal-full-title] Pediatric neurology
  • [ISO-abbreviation] Pediatr. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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