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1. Perez DE, Lopes MA, de Almeida OP, Jorge J, Kowalski LP: Plasmacytoid myoepithelioma of the palate in a child. Int J Paediatr Dent; 2007 May;17(3):223-7
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  • BACKGROUND: Myoepithelioma is a rare benign salivary gland tumour, localized most frequently in the parotid and in minor intraoral salivary glands.
  • The diagnosis was consistent with myoepithelioma, plasmocytoid variant.
  • Tumour cells were positive for cytokeratins, vimentin and S-100 protein.
  • Surgical resection was performed and no evidences of tumour recurrence were observed after 6 years of the treatment.
  • CONCLUSION: Myoepithelioma is a very rare tumour in children and apparently presents a good prognosis, similar to occur in adult patients.

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  • (PMID = 17397468.001).
  • [ISSN] 0960-7439
  • [Journal-full-title] International journal of paediatric dentistry
  • [ISO-abbreviation] Int J Paediatr Dent
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins
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2. Tamiolakis D, Chimona TS, Georgiou G, Proimos E, Nikolaidou S, Perogamvrakis G, Papadakis CE: Accessory parotid gland carcinoma ex pleomorphic adenoma. Case study diagnosed by fine needle aspiration. Stomatologija; 2009;11(1):37-40
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  • [Title] Accessory parotid gland carcinoma ex pleomorphic adenoma. Case study diagnosed by fine needle aspiration.
  • OBJECTIVE: The accessory parotid gland is salivary tissue separated from the main parotid gland and lying on masseter muscle.
  • The accessory parotid gland exists in 21-61% of individuals.
  • However, the appearance of an accessory parotid tumor is rare, with a reported frequency of 1-7.7% of all parotid gland tumors.
  • Carcinoma ex pleomorphic adenoma arises from a pre-existing benign mixed tumor.
  • Reports of Fine Needle Aspiration Cytological (FNAC) diagnosis of malignant mixed tumor are uncommon and have been limited to cases arising in the parotid.

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  • (PMID = 19423970.001).
  • [ISSN] 1392-8589
  • [Journal-full-title] Stomatologija
  • [ISO-abbreviation] Stomatologija
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Lithuania
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3. Craver RD, Fonseca P, Carr R: Pediatric epithelial salivary gland tumors: spectrum of histologies and cytogenetics at a children's hospital. Pediatr Dev Pathol; 2010 Sep-Oct;13(5):348-53
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  • [Title] Pediatric epithelial salivary gland tumors: spectrum of histologies and cytogenetics at a children's hospital.
  • There are conflicting reports regarding the relative frequency of benign and malignant epithelial salivary gland tumors in children.
  • A retrospective 14 year review of epithelial salivary gland tumors encountered at a children's hospital identified 13 tumors: 12 PAs and 1 acinic cell carcinoma (ACC).
  • One tumor with ins(18;8)(q21.1;q12q22.2) had no PLAG1 staining, but stained with HMGA2.
  • [MeSH-major] Adenoma, Pleomorphic / genetics. Adenoma, Pleomorphic / pathology. Salivary Gland Neoplasms / genetics. Salivary Gland Neoplasms / pathology

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  • (PMID = 20055685.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / HMGA2 Protein; 0 / PLAG1 protein, human
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4. Vargas PA, Cheng Y, Barrett AW, Craig GT, Speight PM: Expression of Mcm-2, Ki-67 and geminin in benign and malignant salivary gland tumours. J Oral Pathol Med; 2008 May;37(5):309-18
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  • [Title] Expression of Mcm-2, Ki-67 and geminin in benign and malignant salivary gland tumours.
  • BACKGROUND: Recent studies have proposed that minichromosome maintenance (Mcm) proteins may be sensitive proliferation markers and may serve as novel biomarkers for prognostication and diagnosis of various pre-malignant and malignant lesions.
  • The aims of this study were to determine the expression of Mcm-2, Ki-67 and geminin in salivary gland (SG) tumours, and to evaluate their usefulness for diagnosis or for prediction of tumour behaviour.
  • LI did not correlate to tumour grade or outcome for any of the markers or tumour types.
  • CONCLUSIONS: The findings suggest that Mcm-2 may be a sensitive proliferation marker in SG tumours and may be useful for differential diagnosis between PA and CEPA, and ACC and PLGA.
  • [MeSH-major] Biomarkers, Tumor / biosynthesis. Cell Cycle Proteins / biosynthesis. Ki-67 Antigen / biosynthesis. Nuclear Proteins / biosynthesis. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / metabolism. Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / metabolism. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Acinar Cell / diagnosis. Carcinoma, Acinar Cell / metabolism. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / metabolism. Cell Proliferation. Diagnosis, Differential. Female. Geminin. Humans. Immunoenzyme Techniques. Male. Microarray Analysis. Middle Aged. Minichromosome Maintenance Complex Component 2. Neoplasm Proteins / biosynthesis

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  • (PMID = 18248354.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / GMNN protein, human; 0 / Geminin; 0 / Ki-67 Antigen; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; EC 3.6.4.12 / MCM2 protein, human; EC 3.6.4.12 / Minichromosome Maintenance Complex Component 2
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5. Yang S, Chen X, Wang L, Zhang J: Non-sebaceous lymphadenoma of the salivary gland: case report with immunohistochemical investigation. Virchows Arch; 2007 May;450(5):595-9
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  • [Title] Non-sebaceous lymphadenoma of the salivary gland: case report with immunohistochemical investigation.
  • Non-sebaceous lymphadenoma (NSL) is a rare, recently described, benign salivary gland tumor characterized by a dense lymphoid infiltrate and absence of sebaceous differentiation.
  • The patient was a 50-year-old woman presenting with a slowly growing painless mass in the right parotid gland.
  • The tumor was encapsulated and measured 3 x 2 x 2 cm.
  • Microscopically, the tumor comprised islands of epithelial cells with centrally located duct-like structures within a dense lymphoid stroma.
  • Immunohistochemically, the tumor regularly expressed CKs 7, 8/18, and 19, which are typical for columnar differentiation and CKs 17 and 5/6, which are most typically expressed in basal cells of complex epithelia.
  • [MeSH-major] Lymphoma / pathology. Parotid Gland / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Female. Humans. Keratins / analysis. Middle Aged. Treatment Outcome

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  • (PMID = 17431672.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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6. Ozawa H, Tomita T, Sakamoto K, Tagawa T, Fujii R, Kanzaki S, Ogawa K, Kameyama K, Fujii M: Mucoepidermoid carcinoma of the head and neck: clinical analysis of 43 patients. Jpn J Clin Oncol; 2008 Jun;38(6):414-8
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  • While the high-grade type is a highly aggressive tumor, its low-grade counterpart usually demonstrates a more benign nature and several systems have, therefore, been proposed to grade this neoplasm.
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Analysis of Variance. Disease-Free Survival. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Predictive Value of Tests. Prognosis. Proportional Hazards Models. Radiotherapy, Adjuvant. Retrospective Studies. Salivary Gland Neoplasms / therapy. Sex Factors. Treatment Outcome

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  • (PMID = 18573852.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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7. Singh A, Pandey KC, Pant NK: Cavitary mucoepidermoid carcinoma of lung with metastases in skeletal muscles as presenting features: a case report and review of the literature. J Cancer Res Ther; 2010 Jul-Sep;6(3):350-2
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  • MECs, the most common malignancy in salivary glands, were earlier thought to occur only in salivary glands.
  • Later studies showed that they can arise as a primary in bronchus, esophagus, lacrimal glands, pancreas, thymus and thyroid gland.
  • Initially described as a benign adenoma, it is now considered to be a malignant epithelial tumor.
  • [MeSH-major] Carcinoma, Mucoepidermoid / diagnosis. Lung Neoplasms / diagnosis. Muscle Neoplasms / secondary. Muscle, Skeletal / pathology

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  • (PMID = 21119274.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
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8. Daneshbod Y, Khademi B, Kadivar M, Ganjei-Azar P: Fine needle aspiration of salivary gland lesions with multinucleated giant cells. Acta Cytol; 2008 Nov-Dec;52(6):671-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine needle aspiration of salivary gland lesions with multinucleated giant cells.
  • OBJECTIVE: To report on multinucleated giant cells (MNGCs) in salivary fine needle aspiration (FNA).
  • STUDY DESIGN: The cytologic reports of salivary gland region FNA during a 10-year period was searched using the keyword giant cell in the final diagnosis or microscopic description.
  • RESULTS: Twenty-six aspiration smears containing MNGCs were identified from 1040 salivary gland FNAs (2.5%).
  • MNGCs were seen in some reactive or inflammatory conditions, benign neoplasms and malignant neoplasms.
  • By type of MNGC, the salivary lesions were categorized in 3 groups: those with foreign body type, osteoclast type and tumor giant cells.
  • CONCLUSION: MNGCs can be seen in a wide spectrum of salivary gland lesions ranging from reactive to benign and malignant.
  • [MeSH-major] Giant Cell Tumors / pathology. Giant Cells / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Young Adult


9. Maruyama S, Cheng J, Shingaki S, Tamura T, Asakawa S, Minoshima S, Shimizu Y, Shimizu N, Saku T: Establishment and characterization of pleomorphic adenoma cell systems: an in-vitro demonstration of carcinomas arising secondarily from adenomas in the salivary gland. BMC Cancer; 2009;9:247
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  • [Title] Establishment and characterization of pleomorphic adenoma cell systems: an in-vitro demonstration of carcinomas arising secondarily from adenomas in the salivary gland.
  • BACKGROUND: Among the salivary gland carcinomas, carcinoma in pleomorphic adenoma has been regarded as a representative carcinoma type which arises secondarily in the background of a pre-existent benign pleomorphic adenoma.
  • It is still poorly understood how and which benign pleomorphic adenoma cells transform into its malignant form, carcinoma ex pleomorphic adenoma.
  • METHODS: We have established five cell systems from a benign pleomorphic adenoma of the parotid gland of a 61-year-old woman.
  • RESULTS: We established and characterized five cell systems (designated as SM-AP1 to SM-AP5) from a benign pleomorphic adenoma of the parotid gland.
  • Among them, der(9)t(9;13)(p13.3;q12.3) was shared by all five of the cell systems.
  • In addition, they had ductal arrangements or plasmacytoid appearances of tumor cells and myxoid or hyaline stromata, indicating some characteristics of pleomorphic adenoma.
  • The histological features of squamous cell carcinoma from the transplanted cell systems in nude mice might suggest a secondary onset of malignancy from a pre-existing benign adenoma.
  • [MeSH-major] Adenoma / metabolism. Adenoma / pathology. Carcinoma / metabolism. Carcinoma / secondary. Salivary Gland Neoplasms / metabolism. Salivary Gland Neoplasms / secondary
  • [MeSH-minor] Animals. Chromosomes, Artificial, Bacterial. DNA Mutational Analysis. Female. Genes, p53. Humans. Immunohistochemistry / methods. In Situ Hybridization, Fluorescence. Mice. Mice, Nude. Microscopy, Fluorescence / methods. Middle Aged. Neoplasm Transplantation. Tumor Cells, Cultured


10. Debnath SC, Saikia AK, Debnath A: Pleomorphic adenoma of the palate. J Maxillofac Oral Surg; 2010 Dec;9(4):420-3
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  • Pleomorphic adenoma is a benign tumor of the salivary glands that has elements of both epithelial and mesenchymal tissues.
  • The tumor most commonly arises in the parotid or submandibular glands.
  • Infrequently, it may arise from the minor salivary glands and present as an intraoral mass over the palate or lip.

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  • (PMID = 22190837.001).
  • [ISSN] 0974-942X
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3177488
  • [Keywords] NOTNLM ; Palate / Pleomorphic adenoma / Salivary gland
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11. Azevedo Rde S, Pires FR, Della Coletta R, de Almeida OP, Kowalski LP, Lopes MA: Oral myofibromas: report of two cases and review of clinical and histopathologic differential diagnosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Jun;105(6):e35-40
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  • [Title] Oral myofibromas: report of two cases and review of clinical and histopathologic differential diagnosis.
  • Myofibroma is a benign mesenchymal neoplasm composed of myofibroblasts which has been described with different synonyms since the first report in 1951.
  • Differential diagnosis included benign and malignant mesenchymal neoplasms, salivary gland tumors, and reactive processes.
  • Microscopic analysis of both lesions revealed a spindle cell tumor with immunoreactivity for vimentin, muscle-specific actin, and specific smooth muscle isoform alpha-actin, rendering the diagnoses of myofibroma.
  • Myofibroma presents a wide range of differential diagnosis, including benign and malignant neoplasms.
  • Therefore, accurate diagnosis may avoid an unnecessary aggressive therapy.
  • [MeSH-minor] Actins / analysis. Child. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Vimentin / analysis

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  • (PMID = 18417385.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Vimentin
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12. Eida S, Sumi M, Nakamura T: Multiparametric magnetic resonance imaging for the differentiation between benign and malignant salivary gland tumors. J Magn Reson Imaging; 2010 Mar;31(3):673-9
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  • [Title] Multiparametric magnetic resonance imaging for the differentiation between benign and malignant salivary gland tumors.
  • PURPOSE: To evaluate the stepwise approach in differentiating between benign and malignant salivary gland tumors using time-intensity curves (TICs) and apparent diffusion coefficients (ADCs).
  • MATERIALS AND METHODS: TICs and ADCs were analyzed on the tumor-by-tumor (overall) and pixel-by-pixel (TIC and ADC maps) bases in patients with benign (n = 52) or malignant (n = 18) salivary gland tumor.
  • CONCLUSION: We propose a stepwise approach by using multiparametric MRI techniques as an effective tool for differentiating between benign and malignant salivary gland tumors.
  • [MeSH-major] Algorithms. Image Enhancement / methods. Image Interpretation, Computer-Assisted / methods. Magnetic Resonance Imaging / methods. Salivary Gland Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Male. Middle Aged. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 20187211.001).
  • [ISSN] 1522-2586
  • [Journal-full-title] Journal of magnetic resonance imaging : JMRI
  • [ISO-abbreviation] J Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Prabhu S, Kaveri H, Rekha K: Benign, malignant salivary gland tumors: comparison of immunohistochemical expression of e-cadherin. Oral Oncol; 2009 Jul;45(7):594-9
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  • [Title] Benign, malignant salivary gland tumors: comparison of immunohistochemical expression of e-cadherin.
  • The aim of the present study was to assess any variation in the immunohistochemical expression of E-cadherin in benign and malignant salivary gland tumors.
  • A total of 60 cases of benign and malignant salivary gland tumors were evaluated immunohistochemically for E-cadherin expression.
  • 48 cases (80%) showed positive expression, in which benign tumors exhibited relatively increased reactivity (85.7%) as compared to the malignant tumors (78.3%).
  • [MeSH-major] Biomarkers, Tumor / metabolism. Cadherins / metabolism. Salivary Gland Neoplasms / metabolism

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  • (PMID = 18955011.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins
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14. Seethala RR, LiVolsi VA, Zhang PJ, Pasha TL, Baloch ZW: Comparison of p63 and p73 expression in benign and malignant salivary gland lesions. Head Neck; 2005 Aug;27(8):696-702
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  • [Title] Comparison of p63 and p73 expression in benign and malignant salivary gland lesions.
  • In this study, we examined the expression of p63 and p73 in 50 various benign salivary gland lesions and 45 malignant salivary gland tumors.
  • METHODS: The 95 salivary gland tumors were selected from the archives of the Department of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania.
  • RESULTS: In benign lesions, p63 and p73 nuclear reactivity was seen in 46 (92%) of 50 and 47 (94%) of 50 cases, respectively.
  • CONCLUSIONS: Hence, p63 and p73 expression is retained in both benign and malignant salivary gland tumors with basaloid or myoepithelial differentiation.
  • [MeSH-major] DNA-Binding Proteins / biosynthesis. Myoepithelioma / pathology. Nuclear Proteins / biosynthesis. Phosphoproteins / biosynthesis. Salivary Gland Neoplasms / pathology. Trans-Activators / biosynthesis
  • [MeSH-minor] Biomarkers, Tumor. Gene Expression Regulation, Neoplastic. Genes, Tumor Suppressor. Humans. Immunohistochemistry. Transcription Factors. Tumor Suppressor Proteins

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  • [Copyright] Copyright 2005 Wiley Periodicals, Inc.
  • (PMID = 16021638.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / Phosphoproteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 0 / tumor suppressor protein p73
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15. Dalati T, Hussein MR: Juvenile pleomorphic adenoma of the cheek: a case report and review of literature. Diagn Pathol; 2009;4:32
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  • Pleomorphic adenoma, also called benign mixed tumor, is the most common tumor of the salivary glands.
  • About 90% of these tumors occur in the parotid gland and 10% in the minor salivary glands.
  • The most common sites of pleomorphic adenoma of the minor salivary glands are the palates followed by lips and cheeks.
  • Here we report a case of pleomorphic adenoma of minor salivary glands of the cheek in a 17-year-old girl.
  • To conclude, pleomorphic adenoma should be considered in the differential diagnosis of cheek masses in youngsters.

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  • (PMID = 19772659.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2759908
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16. Colella G, Giudice A, Vicidomini A, Sperlongano P: Usefulness of the LigaSure vessel sealing system during superficial lobectomy of the parotid gland. Arch Otolaryngol Head Neck Surg; 2005 May;131(5):413-6
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  • [Title] Usefulness of the LigaSure vessel sealing system during superficial lobectomy of the parotid gland.
  • OBJECTIVE: To evaluate the usefulness of the LigaSure Precise instrument in superficial lobectomy of the parotid gland.
  • Patients Thirty-five patients with a parotid gland benign tumor were randomly allocated to 2 superficial lobe parotidectomy groups: 17 using the LigaSure procedure (group A) and 18 using the conventional method (group B).
  • MAIN OUTCOME MEASURES: During the past few years, different methods of achieving hemostasis in parotid gland surgery have been tested as means of decreasing operative time and facial nerve injuries by controlling bleeding.
  • With the whole LigaSure Vessel Sealing System, we experienced the usefulness of the LigaSure Precise instrument in superficial lobectomy of the parotid gland.
  • RESULTS: No statistically significant differences were noted between the 2 groups in mean age, tumor diameter, length of hospital stay, time to return to work, or number of adverse events during or after surgery.
  • Salivary fistulas were more common in group A (3 of 17 patients), with no cases in group B.

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  • (PMID = 15897420.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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17. Shiomori T, Udaka T, Tokui N, Morio T, Ohbuchi T, Suzuki H: Giant myoepithelioma of the upper lip. Acta Otolaryngol; 2005 Aug;125(8):894-8
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  • Myoepithelioma is a relatively rare form of salivary gland tumor composed entirely of myoepithelial cells.
  • This tumor was formerly considered to be a subtype of pleomorphic adenoma; however, in the latest World Health Organization classification of 1991 it is listed as an independent entity.
  • CT and MRI revealed a 50 x 40 mm(2) well-defined ovoid tumor.
  • A benign minor salivary gland tumor was clinically suspected, and the patient underwent complete resection of the tumor under general anesthesia.
  • The tumor was histopathologically diagnosed as a benign myoepithelioma of the minor salivary gland.
  • Immunohistochemically, the tumor cells were positive for vimentin, cytokeratins, alpha-smooth muscle actin and S-100 protein, confirming the morphological diagnosis of myoepithelioma.
  • [MeSH-major] Lip Neoplasms / diagnosis. Myoepithelioma / diagnosis. Salivary Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Reconstructive Surgical Procedures / methods. Salivary Glands, Minor. Surgical Flaps. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16099771.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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18. Röser K, Jäkel KT, Bullerdiek J, Löning T: [Significance of molecular-cytogenetic findings in mucoepidermoid carcinoma as an example of salivary gland tumors]. Pathologe; 2005 Sep;26(5):359-66
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  • [Title] [Significance of molecular-cytogenetic findings in mucoepidermoid carcinoma as an example of salivary gland tumors].
  • [Transliterated title] Bedeutung molekular-zytogenetischer Befunde bei Speicheldrüsentumoren am Beispiel des Mukoepidermoidkarzinoms.
  • Pending the elucidation of the t(11;19) at the molecular level of an apparently identical chromosomal translocation in Warthin's tumor, the identification of the translocation in MEC by FISH- and/or RT-PCR-analyses may become important in diagnosis and might have prognostic relevance.
  • Warthin's tumors are benign salivary gland neoplasms with a distinctive histomorphology and histogenesis completely different from MEC.
  • [MeSH-major] Carcinoma, Mucoepidermoid / genetics. Carcinoma, Mucoepidermoid / pathology. Chromosome Aberrations. Salivary Gland Neoplasms / genetics. Translocation, Genetic

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  • (PMID = 16075259.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / MECT1-MAML2 fusion protein, human; 0 / Oncogene Proteins, Fusion
  • [Number-of-references] 27
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19. Bień S, Kamiński B, Kopczyński J, Sygut J: [The synchroneous tumors of different histopathology in the parotid salivary gland]. Otolaryngol Pol; 2006;60(5):703-8
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  • [Title] [The synchroneous tumors of different histopathology in the parotid salivary gland].
  • Ipsilateral salivary gland tumors of different histological types are very rare.
  • In 5 cases pleomorphic adenoma was one of synchronous tumor--in 2 cases with adenocarcinoma and in single cases with salivary duct carcinoma, adenolymphoma, and myoepithelioma.
  • Following the review of literature concerning the problem, two concepts has been critically discussed--the real synchronous occurrence of two different tumors, and transformation of benign tumor of salivary neoplasm to its malignant form.
  • [MeSH-minor] Adenolymphoma / pathology. Adenoma, Pleomorphic / pathology. Adult. Carcinoma, Squamous Cell / pathology. Female. Humans. Male. Middle Aged. Neoplasm Metastasis

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  • (PMID = 17263242.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Number-of-references] 24
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20. Kawahara A, Harada H, Mihashi H, Akiba J, Kage M: Cytological features of cystadenocarcinoma in cyst fluid of the parotid gland: Diagnostic pitfalls and literature review. Diagn Cytopathol; 2010 May;38(5):377-81
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  • [Title] Cytological features of cystadenocarcinoma in cyst fluid of the parotid gland: Diagnostic pitfalls and literature review.
  • Cystadenocarcinoma is a rare malignant tumor, with an estimated incidence of 2% of malignant salivary gland tumors.
  • Cytological diagnosis of cystadenocarcinoma is important for differential diagnosis between benign lesions and malignant tumors with cystic growth.
  • We report a case of cystadenocarcinoma causing difficulty in cytological diagnosis.
  • A 23-year-old man presented with an asymptomatic mass in the left parotid gland that had been present for 2 years.
  • Preoperative fine-needle aspiration cytology (FNAC) showed a small number of tumor cell clusters in the cystic fluid.
  • Tumor cells had a small vacuolated, soap-bubble appearance in the cytoplasm.
  • Histologically, the tumor was not encapsulated, but formed large cystic spaces against a background of fibrous connective tissue.
  • The tumor cells in the cystic dilated duct showed papillary structures, which were continuous with the lining cuboidal cells.
  • As tumor cells with a small vacuolated, soap-bubble appearance of the cytoplasm are common findings of both cystadenocarcinoma and ACC-PCV, they are of little use for differentiation; however, they are so characteristic that the majority of benign salivary gland lesions with cystic structures can be excluded, if enough attention is paid.
  • [MeSH-major] Cyst Fluid / cytology. Cystadenocarcinoma / diagnosis. Cystadenocarcinoma / pathology. Diagnostic Errors. Parotid Gland / pathology. Parotid Neoplasms / diagnosis. Parotid Neoplasms / pathology

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  • (PMID = 19927358.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 110
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21. Ito FA, Ito K, Vargas PA, de Almeida OP, Lopes MA: Salivary gland tumors in a Brazilian population: a retrospective study of 496 cases. Int J Oral Maxillofac Surg; 2005 Jul;34(5):533-6
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  • [Title] Salivary gland tumors in a Brazilian population: a retrospective study of 496 cases.
  • Salivary gland tumors are uncommon and the microscopical features can be complex.
  • In this study, 496 epithelial and mesenchymal tumors of major and minor salivary glands diagnosed at Londrina Cancer Institute during the period from 1972 to 2001 were reviewed.
  • Out of all cases, 335 (67.5%) were classified as benign and 161 (32.5%) as malignant.
  • The majority of the cases occurred in the parotid gland (67.7%), followed by the minor salivary glands (22.8%) and submandibular gland (9.5%).
  • Among the minor salivary gland tumors, the palate was the most frequent location (67%).
  • Pleomorphic adenoma was the most frequent tumor representing 54.2% of all cases, followed by mucoepidermoid carcinoma (13.5%), Warthin's tumor (8.5%) and adenoid cystic carcinoma (7.9%).
  • [MeSH-major] Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adenolymphoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Brazil / epidemiology. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Mucoepidermoid / epidemiology. Child. Female. Humans. Male. Middle Aged. Neoplasms, Glandular and Epithelial / epidemiology. Palate / pathology. Parotid Neoplasms / epidemiology. Retrospective Studies. Salivary Glands, Minor / pathology. Sex Factors. Submandibular Gland Neoplasms / epidemiology

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  • (PMID = 16053874.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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22. Yaor MA: The pattern of presentation of salivary gland tumors in Africa: A review of published reports. Ear Nose Throat J; 2010 Feb;89(2):E17-21
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  • [Title] The pattern of presentation of salivary gland tumors in Africa: A review of published reports.
  • Salivary glands are the site of a wide variety of histopathologic types of benign and malignant tumors.
  • The author reviewed 23 articles from 12 African countries published between 1980 and 2004 to examine patterns of salivary gland tumors.
  • Also, there may be a female preponderance in Africa, and Warthin tumor is rare.
  • [MeSH-major] Adenoma, Pleomorphic / epidemiology. Adenoma, Pleomorphic / pathology. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Adenoid Cystic / pathology. Salivary Gland Neoplasms / epidemiology. Salivary Gland Neoplasms / pathology

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  • (PMID = 20155665.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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23. Thakur JS, Mohindroo NK, Mohindroo S, Sharma DR, Thakur A: Pleomorphic adenoma of minor salivary gland with therapeutic misadventure: a rare case report. BMC Ear Nose Throat Disord; 2010;10:2
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  • [Title] Pleomorphic adenoma of minor salivary gland with therapeutic misadventure: a rare case report.
  • BACKGROUND: The benign tumors of nasopharynx are least encountered tumors in otolaryngology, as nasopharynx is considered one of notorious anatomical site for the malignant tumors.
  • Pleomorphic adenoma of the minor salivary gland of nasopharynx and parapharyngeal space is rare.
  • We present a pleomorphic adenoma of minor salivary gland which was mismanaged.
  • On CT scan, this tumor was quite big and extending to the parapharyngeal space.
  • The excision biopsy of tumor revealed it as pleomorphic adenoma.
  • We found only five published reports on this tumor arising from nasopharynx.
  • DISCUSSION AND CONCLUSION: Although, in this case report exact origin of the tumor could not be ascertained as it also appeared to be a parapharyngeal tumor but we kept the possibility of a nasopharyngeal tumor on the basis of clinical features.
  • It can be misdiagnosed as malignant epithelial tumor on histopathology.
  • A possibility of benign tumor should always be kept in nasopharyngeal growth with no evidence of metastasis, and histopathological diagnosis of growth should be available before any definitive treatment.

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  • (PMID = 20157428.001).
  • [ISSN] 1472-6815
  • [Journal-full-title] BMC ear, nose, and throat disorders
  • [ISO-abbreviation] BMC Ear Nose Throat Disord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2821363
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24. Steele NP, Sampogna D, Sessions RB: Kaposi's sarcoma of an intraparotid lymph node leading to a diagnosis of HIV. Laryngoscope; 2005 May;115(5):861-3
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  • [Title] Kaposi's sarcoma of an intraparotid lymph node leading to a diagnosis of HIV.
  • OBJECTIVE: Kaposi's sarcoma is a common malignancy in patients infected with HIV but is rarely seen in the major salivary glands.
  • If a patient is known to be HIV-positive, however, Kaposi's sarcoma must be considered in the differential diagnosis of salivary gland masses in addition to the benign and malignant neoplasms that occur in immunocompetent patients.
  • We present a unique case in which an otherwise healthy patient was diagnosed with HIV after resection of his enlarged parotid gland revealed Kaposi's sarcoma.
  • The patient's presentation, workup, and final diagnosis of Kaposi's sarcoma are discussed.
  • The patient underwent a right superficial parotidectomy for a suspected diagnosis of Warthin's tumor, given the bilaterality of the lesions.
  • CONCLUSIONS: Although Kaposi's sarcoma is common in AIDS patients, there are few case reports of this malignancy arising in the salivary glands.
  • Previously reported cases include salivary gland Kaposi's sarcoma in known HIV-positive patients and a handful of reports in patients without confirmed immunocompromise.
  • The patient presented here is unique because the diagnosis of parotid gland Kaposi's sarcoma led to a new diagnosis of HIV.
  • This interesting case reiterates the need for complete history taking and the inclusion of Kaposi's sarcoma in the differential diagnosis of salivary gland masses in the appropriate patient population.
  • [MeSH-major] HIV Seropositivity / diagnosis. Parotid Neoplasms / diagnosis. Sarcoma, Kaposi / diagnosis
  • [MeSH-minor] Adenolymphoma / diagnosis. Biopsy, Needle. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Middle Aged


25. Tahoun N, Ezzat N: Diagnostic accuracy and pitfalls of preoperative fine needle aspiration cytology in salivary gland lesions. J Egypt Natl Canc Inst; 2008 Dec;20(4):358-68
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  • [Title] Diagnostic accuracy and pitfalls of preoperative fine needle aspiration cytology in salivary gland lesions.
  • PURPOSE: Evaluation of diagnostic accuracy of preoperative fine needle aspiration cytology (FNAC) in salivary gland lesions.
  • PATIENTS AND METHODS: This is a retrospective study of 82 patients presented at NCI, Cairo University with salivary gland lesion who underwent preoperative FNAC diagnosis with subsequent excision and histopathologic assessment.
  • The definitive histopathologic report according to WHO Histological typing was the gold standard diagnosis against which FNAC was compared.
  • RESULTS: Our study included 82 patients who underwent preoperative FNAC of major salivary glands with subsequent surgical excision.
  • Parotid gland was involved in (68.3%), submandibular in (28%) and submental gland in (3.7%).
  • Forty cases (48.8%) were cytologically diagnosed as benign lesions, 26 (31.7%) were malignant and 10 (12.2%) were suspicious.
  • The most common benign cytologic diagnosis was pleomorphic adenoma; 16 out of 40 cases (40%), while the most common malignant tumor was carcinoma; 22 out of 26 cases (84.6%).
  • The cytologic diagnosis achieved a sensitivity of 91.7%; a specificity of 92.5%, PPV 91.6%, NPV 92.5% and diagnostic accuracy 92%.
  • The rates of agreement of histopathologic type for benign and malignant tumors were 89.2% and 91%, respectively.
  • KEY WORDS: FNAC - Salivary gland lesions - Accuracy - Pitfalls.

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  • (PMID = 20571594.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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26. Daneshbod Y, Daneshbod K, Khademi B: Diagnostic difficulties in the interpretation of fine needle aspirate samples in salivary lesions: diagnostic pitfalls revisited. Acta Cytol; 2009 Jan-Feb;53(1):53-70
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  • [Title] Diagnostic difficulties in the interpretation of fine needle aspirate samples in salivary lesions: diagnostic pitfalls revisited.
  • OBJECTIVE: To present our experience in diagnostic errors and pitfalls on aspiration cytology of salivary region in a high volume of cases.
  • STUDY DESIGN: In a retrospective review of cytology files of a head and neck referral center from 1990 to 2005, the false positive and false negative interpretations on fine needle aspiration (FNA) of salivary lesions were retrieved.
  • These records and slides were reviewed to identify cytologic characteristics that contributed to false diagnosis.
  • RESULTS: Of a total of 1,040 salivary FNA samples, 376 cases had a final histologic diagnosis with interpretations of benign or malignant.
  • The sensitivity and specificity for correct interpretation of benign and malignant were 87% and 96%, respectively.
  • Benign cases with false positive diagnosis were Warthin tumor and pleomorphic adenoma.
  • CONCLUSION: Knowledge of cytologic overlaps and pitfalls on salivary gland FNA, as well as clinical and radiologic features, may help clinicians arrive at the appropriate diagnosis and reduce false interpretations.
  • [MeSH-major] Salivary Gland Neoplasms / diagnosis. Salivary Glands / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Child. Child, Preschool. Diagnosis, Differential. False Negative Reactions. False Positive Reactions. Female. Humans. Infant. Male. Middle Aged. Retrospective Studies. Sensitivity and Specificity. Young Adult

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  • (PMID = 19248555.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Affolter A, Helmbrecht S, Finger S, Hörmann K, Götte K: Altered expression of cell cycle regulators p21, p27, and p53 in tumors of salivary glands and paranasal sinuses. Oncol Rep; 2005 Jun;13(6):1089-94
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  • [Title] Altered expression of cell cycle regulators p21, p27, and p53 in tumors of salivary glands and paranasal sinuses.
  • The role of these cell cycle regulators in tumors of salivary gland and paranasal sinus origin is still unclear.
  • In this study it was intended to demonstrate and compare the expression of p21, p27, and p53 in benign and malignant tumors of salivary glands and paranasal sinuses.
  • The study sheds new light upon the role of CIP/KIP protein family in tumors of salivary glands and paranasal sinuses.
  • Furthermore, it is the first description of p21 and p53 TSA-IHC in these tumor types.
  • [MeSH-major] Adenocarcinoma / metabolism. Carcinoma, Adenoid Cystic / metabolism. Cell Cycle Proteins / metabolism. Paranasal Sinus Neoplasms / metabolism. Paranasal Sinuses / metabolism. Salivary Gland Neoplasms / metabolism. Tumor Suppressor Protein p53 / metabolism. Tumor Suppressor Proteins / metabolism

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  • (PMID = 15870926.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / CDKN1A protein, human; 0 / Cell Cycle Proteins; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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28. Kern MA, Kasper HU, Drebber U, Guntinas-Lichius O, Veelken F, Ortmann M: [Report of a spindle cell myoepithelialioma of the minor salivary glands with extensive lipomatous component]. Laryngorhinootologie; 2005 Jun;84(6):432-5
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  • [Title] [Report of a spindle cell myoepithelialioma of the minor salivary glands with extensive lipomatous component].
  • [Transliterated title] Spindelzelliges Myoepitheliom der kleinen Speicheldrüsen mit ausgeprägter lipomatöser Komponente.
  • Myoepitheliomas of the salivary glands are rare benign tumors composed of spindle-shaped myoepithelial cells, but may show plasmacytoid, epitheloid and clear cell-types that principally exhibit myoepithelial but not ductal differentiation.
  • These tumors are mainly located in the major salivary glands and have sometimes abundant, acellular, mucoid or hyaline stroma but lack chondroid and myxochondroid foci, probably representing the one end of the spectrum of pleomorphic adenoma.
  • Lipomatosis in the form of isolated small islands or scattered single lipocytes, is quite uncommon, and a large amount of adipose tissue in a pleomorphic adenoma and myoepithelioma is a rarity and only described in major salivary glands.
  • We present the case report of a 38-year old man with a myoepithelioma of the minor palatinal salivary glands with extensive lipomatosis as an example of this rare phenomena.
  • [MeSH-major] Lipomatosis / pathology. Myoepithelioma / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology. Uvula / pathology
  • [MeSH-minor] Adipose Tissue / pathology. Adult. Biomarkers, Tumor / analysis. Biopsy, Fine-Needle. Diagnosis, Differential. Humans. Male

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  • (PMID = 15940575.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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29. Eida S, Ohki M, Sumi M, Yamada T, Nakamura T: MR factor analysis: improved technology for the assessment of 2D dynamic structures of benign and malignant salivary gland tumors. J Magn Reson Imaging; 2008 Jun;27(6):1256-62
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  • [Title] MR factor analysis: improved technology for the assessment of 2D dynamic structures of benign and malignant salivary gland tumors.
  • PURPOSE: To establish an MR factor analysis technique for two-dimensional (2D) MR dynamic structures of benign and malignant salivary gland tumors.
  • MATERIALS AND METHODS: Dynamic contrast-enhanced MRI using a surface coil was performed on 36 patients with benign (N = 24) or malignant (N = 12) salivary gland tumors.
  • RESULTS: The MR factor analysis technique allowed the pixel-to-pixel evaluation of the contrast enhancement kinetics of the salivary gland tumors.
  • The 2D distributions of the time-intensity curve (TIC) patterns correlated well with the histological features of the salivary gland tumors and allowed more detailed dynamic structures of the tumors compared with the results obtained by the conventional dynamic study analysis.
  • CONCLUSION: The proposed MR factor analysis would be clinically feasible to diagnose salivary gland tumors and tumor-like lesions.
  • [MeSH-major] Adenocarcinoma / diagnosis. Image Processing, Computer-Assisted / methods. Lymphoma / diagnosis. Magnetic Resonance Imaging / methods. Neoplasms, Complex and Mixed / diagnosis. Salivary Gland Neoplasms / diagnosis. Salivary Glands / pathology
  • [MeSH-minor] Aged. Cohort Studies. Contrast Media / administration & dosage. Diagnosis, Differential. Factor Analysis, Statistical. Feasibility Studies. Female. Gadolinium DTPA. Humans. Image Enhancement / methods. Male. Middle Aged

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  • [Copyright] 2008 Wiley-Liss, Inc
  • (PMID = 18504743.001).
  • [ISSN] 1053-1807
  • [Journal-full-title] Journal of magnetic resonance imaging : JMRI
  • [ISO-abbreviation] J Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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30. Rawlinson NJ, Almarzooqi S, Nicol K: Sebaceous lymphadenoma of the parotid gland in a 13-year-old girl: a case report. Head Neck Pathol; 2010 Jun;4(2):144-7
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  • [Title] Sebaceous lymphadenoma of the parotid gland in a 13-year-old girl: a case report.
  • Sebaceous lymphadenoma is a benign rare tumor of the salivary gland.
  • [MeSH-major] Adenolymphoma / pathology. Parotid Neoplasms / pathology. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Sebaceous / diagnosis. Adolescent. Carcinoma, Mucoepidermoid / diagnosis. Diagnosis, Differential. Female. Humans. Lymphoma / diagnosis

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  • [Cites] Acta Otorhinolaryngol Ital. 2007 Jun;27(3):144-6 [17883193.001]
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  • (PMID = 20512641.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2878632
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31. Gama-de-Souza LN, Cyreno-Oliveira E, Freitas VM, Melo ES, Vilas-Boas VF, Moriscot AS, Jaeger RG: Adhesion and protease activity in cell lines from human salivary gland tumors are regulated by the laminin-derived peptide AG73, syndecan-1 and beta1 integrin. Matrix Biol; 2008 Jun;27(5):402-19
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  • [Title] Adhesion and protease activity in cell lines from human salivary gland tumors are regulated by the laminin-derived peptide AG73, syndecan-1 and beta1 integrin.
  • We studied the induction of protease activity by the laminin alpha1-derived peptide AG73 in cells from adenoid cystic carcinoma (CAC2) and myoepithelioma (M1), respectively a malignant and a benign salivary gland tumors.
  • [MeSH-major] Antigens, CD29 / metabolism. Laminin / pharmacology. Matrix Metalloproteinases / metabolism. Peptide Fragments / pharmacology. Salivary Gland Neoplasms / pathology. Syndecan-1 / metabolism
  • [MeSH-minor] Blotting, Western. Calcium / metabolism. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Cell Adhesion / drug effects. Cell Line, Tumor. Chelating Agents / pharmacology. Dipeptides / pharmacology. Extracellular Matrix / drug effects. Extracellular Matrix / metabolism. Heparin / pharmacology. Humans. Immunohistochemistry. Matrix Metalloproteinase 2 / genetics. Matrix Metalloproteinase 2 / metabolism. Matrix Metalloproteinase 9 / genetics. Matrix Metalloproteinase 9 / metabolism. Matrix Metalloproteinase Inhibitors. Myoepithelioma / genetics. Myoepithelioma / metabolism. Myoepithelioma / pathology. RNA, Small Interfering / genetics. Reverse Transcriptase Polymerase Chain Reaction. Signal Transduction / physiology

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  • (PMID = 18378436.001).
  • [ISSN] 0945-053X
  • [Journal-full-title] Matrix biology : journal of the International Society for Matrix Biology
  • [ISO-abbreviation] Matrix Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / AG 73; 0 / Antigens, CD29; 0 / Chelating Agents; 0 / Dipeptides; 0 / Laminin; 0 / Matrix Metalloproteinase Inhibitors; 0 / N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide; 0 / Peptide Fragments; 0 / RNA, Small Interfering; 0 / SDC1 protein, human; 0 / Syndecan-1; 151186-83-3 / laminin A; 9005-49-6 / Heparin; EC 3.4.24.- / Matrix Metalloproteinases; EC 3.4.24.24 / MMP2 protein, human; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9; SY7Q814VUP / Calcium
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32. Nouraei SA, Ferguson MS, Clarke PM, Sandison A, Sandhu GS, Michaels L, Rhys-Evans P: Metastasizing pleomorphic salivary adenoma. Arch Otolaryngol Head Neck Surg; 2006 Jul;132(7):788-93
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  • [Title] Metastasizing pleomorphic salivary adenoma.
  • OBJECTIVE: To address questions about the etiology, behavior, optimal treatment, and prognosis of metastasizing pleomorphic adenoma (MPA), we undertook a review of the literature (1953-2005) and constructed a virtual series of all identified cases of MPA, metastatic lesions that are very occasionally identified in patients with a history of pleomorphic salivary adenoma and, on detailed pathological evaluation, found to exhibit all the histological hallmarks of the preceding benign lesions.
  • There was an overwhelming history of incomplete surgery for pleomorphic salivary adenoma.
  • Developing distant lesions within 10 years of the primary tumor and presence of metastases in multiple sites were independent predictors of survival on Cox regression analysis.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Proportional Hazards Models. Survival Analysis. Treatment Outcome

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  • (PMID = 16847191.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] United States
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33. Kumar B: Chondroid syringoma diagnosed by fine needle aspiration cytology. Diagn Cytopathol; 2010 Jan;38(1):38-40
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  • Chondroid syringoma is a rare benign skin adnexal tumor of eccrine/apocrine origin affecting commonly the head and neck region.
  • It used to be previously called as mixed tumor of skin because of the presence of both the epithelial and mesenchymal components.
  • There are only few case reports describing the fine needle aspiration cytologic features of chondroid syringoma for diagnosis.
  • A clinical diagnosis of dermoid cyst was entertained, and the case was subjected to FNAC.
  • On the basis of these cytologic features, a diagnosis of chondroid syringoma was made.
  • We concluded that Chondroid syringoma may be considered as a rare differential diagnosis in the swelling of head and neck region and the diagnosis can be easily confirmed or ruled out by means of fine needle aspiration cytology.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / pathology. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / pathology

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19693940.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Daneshbod Y, Khademi B, Moemeni B, Seif I, Daneshbod K: Preoperative washing cytology in the diagnosis of maxillary sinus lesions. Acta Cytol; 2010 Mar-Apr;54(2):148-58
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  • [Title] Preoperative washing cytology in the diagnosis of maxillary sinus lesions.
  • STUDY DESIGN: Over a 4-year period, 96 p tients with clinical or radiologic suspicion of a malignant maxillary sinus tumor either confined to the maxillary complex or extending to the nasal cavity underwent preoperative cytologic evaluation by sinus puncture and local washing or nasal washing.
  • RESULTS: There were 47 malignant, 42 benign and 7 borderline cases.
  • Benign lesions included inflammatory conditions (17), squamous proliferations (6), soft tissue lesions (9) and odontogenic lesions (10).
  • Malignant lesions included squamous cell carcinoma (8), sinonasal adenocarcinoma (2), salivary gland tumors (4), soft tissue tumors (18), malignant melanoma (8) and hematolymphoid neoplasms (7).
  • Diagnostic agreement between cytology and follow-up biopsy was seen mostly in benign inflammatory and odontogenic lesions and in squamous cell carcinoma and salivary gland malignancies.
  • CONCLUSION: Preoperative sinus washing cytology is a noninvasive and rapid method of diagnosis, with a definite impact on patient surgical planning.
  • Clusters of sloughed epithelial cells, so called Creola bodies, may be a diagnostic pitfall in benign lesions.
  • [MeSH-major] Cytodiagnosis / methods. Maxillary Sinus / pathology. Neoplasms / diagnosis

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  • (PMID = 20391970.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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35. Kandasamy J, Smith A, Diaz S, Rose B, O'Brien C: Heterogeneity of PLAG1 gene rearrangements in pleomorphic adenoma. Cancer Genet Cytogenet; 2007 Aug;177(1):1-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pleomorphic adenoma (PA), a benign mixed salivary gland tumor, has been associated with abnormal karyotypes in up to 70% of cases, with nonrandom involvement of 8q12, the locus of the pleomorphic adenoma (PLAG1) gene.
  • Samples of parotid gland tissue from the tumor sites, set up as solid tumor cultures, showed a normal karyotype in two cases [46,XY;46,XX] and cytogenetic abnormalities in five cases (71%).
  • In addition, genomic instability was seen in two cases, one with PLAG1 amplification in the form of a homogeneously staining region, and the other in der(8) ring formation.
  • [MeSH-major] Adenoma, Pleomorphic / genetics. DNA-Binding Proteins / genetics. Gene Rearrangement. Genetic Variation. Salivary Gland Neoplasms / genetics

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  • (PMID = 17693184.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / PLAG1 protein, human
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36. Kondo T: A case of lipomatous pleomorphic adenoma in the parotid gland: a case report. Diagn Pathol; 2009;4:16
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  • [Title] A case of lipomatous pleomorphic adenoma in the parotid gland: a case report.
  • INTRODUCTION: Pleomorphic adenoma is the most common benign neoplasm of the salivary glands.
  • Extensive lipomatous involvement of the tumor is, however, a very rare finding.
  • CASE REPORT: Herein, a rare case of lipomatous pleomorphic adenoma arising in the parotid gland of a 14-year-old Japanese woman is presented.
  • Recognition of this rare subtype of pleomorphic adenoma is important for clinical diagnosis and management.

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  • (PMID = 19497106.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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37. Guzzo M, Ferrari A, Marcon I, Collini P, Gandola L, Pizzi N, Casanova M, Mattavelli F, Scaramellini G: Salivary gland neoplasms in children: the experience of the Istituto Nazionale Tumori of Milan. Pediatr Blood Cancer; 2006 Nov;47(6):806-10
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  • [Title] Salivary gland neoplasms in children: the experience of the Istituto Nazionale Tumori of Milan.
  • BACKGROUND: Epithelial salivary gland tumors are very uncommon in pediatric age.
  • These results are presented in conjunction with a literature review of salivary tumors with a view to providing an up-to-date overview of the clinical course, prognosis, and treatment options for this rare tumor.
  • PROCEDURE: Fifty-two cases of epithelial salivary tumors were reviewed and the clinical-pathological information concerning tumor characteristics, therapy, and follow-up were collected.
  • RESULTS: The major salivary glands were the main site of tumor occurrence (79% of cases arose in parotid glands); 37 patients had benign tumors (pleomorphic adenoma), 15 had malignant tumors (12 mucoepidermoid carcinoma, 9 low grade).
  • All the patients were treated by surgery; local relapses after parotidectomy were 4% and 25%, in benign and malignant tumors, respectively.
  • When tumor enucleation was performed, recurrences occurred in 50% of benign neoplasms.
  • At the time of the report, all patients with benign tumors were alive, 35(95%) without evidence of disease; only one patient with malignant tumor died of disease.
  • CONCLUSIONS: Epithelial salivary glands tumor in children had different characteristics compared with their adult counterpart with respect to the frequency of histotypes and site of occurrence, but their prognosis seems to be similar.
  • Parotidectomy (total or superficial) is the best choice for achieving good cure rates in both benign and malignant tumors.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Carcinoma, Acinar Cell / surgery. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Mucoepidermoid / surgery. Neoplasm Recurrence, Local / surgery. Salivary Gland Neoplasms / surgery

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16425245.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Eida S, Sumi M, Sakihama N, Takahashi H, Nakamura T: Apparent diffusion coefficient mapping of salivary gland tumors: prediction of the benignancy and malignancy. AJNR Am J Neuroradiol; 2007 Jan;28(1):116-21
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  • [Title] Apparent diffusion coefficient mapping of salivary gland tumors: prediction of the benignancy and malignancy.
  • BACKGROUND AND PURPOSE: Preoperative prediction of tumor malignancy is clinically very important, because this information strongly influences the surgical plan.
  • We evaluate the preoperative apparent diffusion coefficient (ADC) maps of benign and malignant salivary gland tumors.
  • MATERIALS AND METHODS: High-resolution MR imaging was performed on 31 patients with benign or malignant salivary gland tumors; ADC maps of the tumors were also obtained.
  • RESULTS: The ADC maps effectively depicted the histologic features of the salivary gland tumors, such as presence of cancer cells, myxomatous tissues, fibrosis, necrosis, cyst formation, and lymphoid tissues.
  • The ADC maps showed that more frequent areas with high ADCs (> or = 1.8 x 10(-3) mm(2)/s) were significantly greater in benign tumors than in malignant tumors.
  • The sensitivity and specificity for high ADC occupying fewer than 5% of the area of a tumor was 89% and 100%, respectively, resulting in 97% accuracy, 100% positive predictive value, and 96% negative predictive value.
  • CONCLUSION: The ADC may provide preoperative tissue characterization of the salivary gland tumors.
  • [MeSH-major] Diffusion Magnetic Resonance Imaging / methods. Image Processing, Computer-Assisted / methods. Salivary Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Parotid Gland / pathology. Salivary Gland Diseases / diagnosis. Sensitivity and Specificity. Sublingual Gland / pathology. Submandibular Gland / pathology

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  • (PMID = 17213436.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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39. Vyrupaev SV: [Treatment of giant tumors of the parotid gland]. Vopr Onkol; 2005;51(1):128-30
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  • [Title] [Treatment of giant tumors of the parotid gland].
  • Since large (<<giant>>) benign mixed tumors of the parotid gland are rare, there is insufficient evidence on the modalities of the facial nerve management.
  • Tumors were located externally of the gland (5), parapharyngeally (2), or both (1).
  • The regularities between the facial nerve location and site of tumor were investigated, and it is suggested that, in difficult cases, search should start from the temporal area since it offers most access.
  • When tumor of parapharyngeal localization is excised, it is desirable to perform double osteotomy in the mental part of the mandible as well as at the point of entry of the lower of the alveolar nerve, to avoid the latter's being traumatized.
  • [MeSH-major] Parotid Gland / pathology. Salivary Gland Neoplasms / surgery

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  • (PMID = 15909823.001).
  • [ISSN] 0507-3758
  • [Journal-full-title] Voprosy onkologii
  • [ISO-abbreviation] Vopr Onkol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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40. Bierc M, Minarowski L, Woźniak L, Chojnowska S, Knas M, Szajda S, Zwierz K: The activity of selected glycosidases in salivary gland tumors. Folia Histochem Cytobiol; 2010 Sep 30;48(3):471-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The activity of selected glycosidases in salivary gland tumors.
  • The monitoring of the patients after salivary gland tumors surgery is an important clinical issue.
  • Still imperfect diagnostic procedures also remain a challenge for searching new sensitive and specific biomarkers of neoplastic processes in salivary glands.
  • The aim of the presented study was an the assessment of the activity of HEX, with its isoforms HEX-A and HEX-B, GLU, GAL, MAN and FUC in salivary gland tumor tissues in comparison to a healthy salivary gland tissues taken during autopsy.
  • A group of 42 patients with benign and malignant salivary gland tumors, aged 25-65 were examined.
  • Fragments of salivary gland tumor tissue, fragments of healthy tissue removed during autopsy, blood serum and saliva were collected from patients with salivary gland tumors and healthy volunteers.
  • In salivary gland tumor tissue the activity of HEX, HEX-A, HEX-B, GAL, FUC was considerably higher than in comparison to healthy salivary gland tissue and ascending trend of activity of GLU, MAN was also noticed.
  • The activity of all lysosomal exoglycosidases in blood serum in patients with salivary gland tumors was considerably higher in comparison to healthy volunteers blood serum.
  • The considerably higher activity of HEX, HEX-A, GLU, GAL, MAN, FUC and descending trend of activity of HEX-B were noticed in saliva of patients with salivary gland tumors in comparison to healthy volunteers.
  • The assessment of HEX in blood serum and saliva of patients with salivary gland tumor can be possibly used in diagnostics and monitoring of salivary glands tumors.

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  • (PMID = 21071355.001).
  • [ISSN] 1897-5631
  • [Journal-full-title] Folia histochemica et cytobiologica
  • [ISO-abbreviation] Folia Histochem. Cytobiol.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Isoenzymes; EC 3.2.1.- / Glycoside Hydrolases; EC 3.2.1.52 / Hexosaminidase A; EC 3.2.1.52 / Hexosaminidase B
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41. Roh JL, Kim JM, Park CI: Synchronous benign and malignant tumors in the ipsilateral parotid gland. Acta Otolaryngol; 2007 Jan;127(1):110-2
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  • [Title] Synchronous benign and malignant tumors in the ipsilateral parotid gland.
  • Synchronous benign and malignant tumors in the ipsilateral salivary glands are extremely rare.
  • A coexisting Warthin's tumor was also diagnosed on microscopic examination of total parotidectomy specimens.
  • We describe this case of rare synchronous salivary gland tumors exhibiting both benign and malignant components with a review of the literature.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / radiography. Adenolymphoma / diagnosis. Neoplasms, Multiple Primary / diagnosis. Parotid Neoplasms / diagnosis

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  • (PMID = 17364340.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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42. Andrade ES, Filho JR, Rocha NS, Neto IC, Camargo IB: Isolated intra-oral granular cell tumor: report of two cases and review of the literature. Acta Odontol Latinoam; 2010;23(2):99-104
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  • [Title] Isolated intra-oral granular cell tumor: report of two cases and review of the literature.
  • Granular cell tumor (GCT) is a relatively uncommon lesion occurring in almost any part of the body, including the orofacial region.
  • Although aggressive and malignant variants of this neoplasm have been described, most GCTs are benign.
  • The tumor generally occurs in middle-aged or older adults.
  • As most granular cell tumors are benign, surgical excision of the lesion is the treatment of choice.
  • Differential diagnoses include fibrous hyperplasia, minor salivary gland tumor condyloma acuminatum and neurilemmoma.
  • The main clinical pathology and diagnostic features of this neoplasm are reviewed and discussed.
  • [MeSH-major] Granular Cell Tumor / pathology. Tongue Neoplasms / pathology

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  • (PMID = 21053681.001).
  • [ISSN] 0326-4815
  • [Journal-full-title] Acta odontológica latinoamericana : AOL
  • [ISO-abbreviation] Acta Odontol Latinoam
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Argentina
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43. Patil DT, Chou PM: Sialoblastoma: utility of Ki-67 and p53 as a prognostic tool and review of literature. Pediatr Dev Pathol; 2010 Jan-Feb;13(1):32-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Sialoblastoma is a rare tumor of the salivary gland that commonly occurs in the parotid gland and occasionally in the sub-mandibular gland.
  • In the last 15 years, we have encountered 2 cases of sialoblastoma, in a newborn and in a 15-year-old boy, both arising within the parotid gland.
  • Case 1 has been previously reported and although there were 2 recurrences, at 1 and 9 years post resection, it has shown benign biological behavior.
  • Although both cases showed similar cytomorphologic features, there was a significant difference in Ki-67 expression: 20% in case 1 (original tumor), <2% in case 1 (recurrent tumor), and nearly 70-80% in the recent malignant case.
  • This report highlights the potential utility of proliferation markers such as Ki-67 in concert with p53 expression to better predict the biological behavior of a rare but locally aggressive neoplasm.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Ki-67 Antigen / metabolism. Neoplasms, Glandular and Epithelial / metabolism. Parotid Neoplasms / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 20001735.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
  • [Number-of-references] 33
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44. Drivas EI, Skoulakis CE, Symvoulakis EK, Bizaki AG, Lachanas VA, Bizakis JG: Pattern of parotid gland tumors on Crete, Greece: a retrospective study of 131 cases. Med Sci Monit; 2007 Mar;13(3):CR136-40
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  • [Title] Pattern of parotid gland tumors on Crete, Greece: a retrospective study of 131 cases.
  • BACKGROUND: Salivary gland tumors constitute a highly heterogeneous group.
  • There are few large epidemiological studies of benign and malignant salivary gland tumors in Greece.
  • The aim of the present study was to define the pattern of parotid gland neoplasms on the island of Crete.
  • RESULTS: There were 101 (77.1%) benign parotid gland tumors and 30 (22.9%) of malignant ones.
  • The most common benign tumor was pleomorphic adenoma (44.2%), while the most common malignant tumor was mucoepidermoid carcinoma (5.3%).
  • Median age was 48.2 years (range: 16-75 years) in patients with benign tumors and 65.4 years (range: 27-90 years) in patients with malignancy.
  • CONCLUSIONS: On Crete, parotid gland tumors show epidemiological characteristics similar to studies worldwide.
  • Benign parotid tumors are largely more frequent than malignant tumors.
  • The most common benign parotid gland tumor was pleomorphic adenoma, while the most frequent malignant tumor was mucoepidermoid carcinoma.

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  • (PMID = 17325637.001).
  • [ISSN] 1234-1010
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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45. Ceylan A, Celenk F, Poyraz A, Uslu S: Pleomorphic adenoma of the nasal columella. Pathol Res Pract; 2008;204(4):273-6
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  • Pleomorphic adenoma (mixed tumor) is the most common benign neoplasm of the salivary glands.
  • It is considered to occur primarily in the major salivary glands, such as the parotid and submandibular glands.
  • It is much less common in the minor salivary glands, and rarely occurs at other sites, such as larynx, pharynx, trachea, lacrimal gland, and sinonasal tract.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Neoplasm Recurrence, Local. Neoplasm Seeding. Nose Neoplasms / pathology

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  • (PMID = 18295980.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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46. Aikawa T, Kishino M, Masuda T, Isomura ET, Tanaka S, Namikawa M, Iida S: Intraductal papilloma arising from sublingual minor salivary gland: case report and immunohistochemical study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 May;107(5):e34-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraductal papilloma arising from sublingual minor salivary gland: case report and immunohistochemical study.
  • Intraductal papilloma is a rare benign salivary gland tumor.
  • This lesion is commonly observed in the duct of the minor salivary gland, predominantly in lip and buccal mucosa, but the case in the sublingual region is quite rare.
  • This report shows a first case of intraductal papilloma developed in minor salivary gland of sublingual region.
  • The excised specimen was histologically diagnosed as intraductal papilloma of minor salivary gland, according to the microscopic finding of the papillary growth of ductal epithelium into the ductal space with fibrovascular core.
  • Immunohistochemical study showed the tumor cells originated from ductal luminal cells because of positive Cytokeratin 18 and 7 staining in both types of cells.
  • [MeSH-major] Papilloma / pathology. Salivary Gland Neoplasms / pathology. Sublingual Gland / pathology

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  • [ErratumIn] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Sep;108(3):475. Tomonao, Aikawa [corrected to Aikawa, Tomonao]
  • (PMID = 19426904.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-18; 0 / Keratin-7
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47. Constantinescu MB, Chan JB, Cassarino DS: Chondroid syringoma with tyrosine crystals: case report and review of the literature. Am J Dermatopathol; 2010 Apr;32(2):171-4
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  • Chondroid syringoma (CS) is a relatively rare cutaneous mixed tumor arising from sweat glands.
  • CSs share morphologic similarities with their salivary gland counterparts, pleomorphic adenomas (benign mixed tumors).
  • Although the presence of tyrosine-rich crystalloids in mixed tumors of the salivary gland is well recognized, to our knowledge, this finding has not been previously described in mixed tumors of the skin.
  • [MeSH-major] Sweat Gland Neoplasms / diagnosis. Sweat Gland Neoplasms / metabolism. Syringoma / diagnosis. Syringoma / metabolism. Tyrosine / metabolism

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  • (PMID = 19851085.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 42HK56048U / Tyrosine
  • [Number-of-references] 29
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48. Andreadis D, Epivatianos A, Mireas G, Nomikos A, Poulopoulos A, Yiotakis J, Barbatis C: Immunohistochemical detection of E-cadherin in certain types of salivary gland tumours. J Laryngol Otol; 2006 Apr;120(4):298-304
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical detection of E-cadherin in certain types of salivary gland tumours.
  • OBJECTIVES: To investigate the topography of E-cadherin and its possible correlation with the histological phenotype of salivary gland tumours.
  • MATERIAL AND METHODS: Archival formalin-fixed, paraffin-embedded sections of 54 benign and 56 malignant tumours and 24 samples of normal and inflamed salivary gland tissue were studied immunohistochemically using an Envision/horseraddish peroxidase (HRP) technique.
  • RESULTS: In normal and inflamed salivary gland samples, E-cadherin was expressed at the membrane of acinar, myoepithelial and ductal cells located at cell-cell contact points.
  • Furthermore, a weak to moderate loss of expression which was related to tissue tumour subtype was seen in malignant tumours such as: adenoid cystic carcinomas; polymorphous low-grade adenocarcinomas; acinic cell carcinomas; and mucoepidermoid low-grade, epithelial-myoepithelial, lymphoepithelial and squamous low-grade carcinomas.
  • Moderate to extreme loss or alternative cytoplasmic non-functional expression were observed in cases of salivary ductal carcinoma, carcinosarcoma, myoepithelial carcinoma, oncocytic adenocarcinoma, unspecified adenocarcinoma and squamous high-grade carcinomas.
  • CONCLUSION: This study suggests a direct association of E-cadherin expression with neoplastic histologic phenotype, which is lost in the more undifferentiated and invasive epithelial salivary gland tumours.
  • [MeSH-major] Adenocarcinoma / chemistry. Biomarkers, Tumor / analysis. Cadherins / analysis. Carcinoma, Adenoid Cystic / chemistry. Carcinoma, Ductal / chemistry. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Adenolymphoma / chemistry. Adenoma / chemistry. Adenoma, Pleomorphic / chemistry. Humans. Immunohistochemistry / methods. Salivary Gland Diseases / metabolism. Salivary Glands / chemistry

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  • (PMID = 16623973.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins
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49. Zhang Y, Gomez-Fernandez CR, Jorda M, Ganjei-Azar P: Fine-needle aspiration (FNA) and pleural fluid cytology diagnosis of benign metastasizing pleomorphic adenoma of the parotid gland in the lung: a case report and review of literature. Diagn Cytopathol; 2009 Nov;37(11):828-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine-needle aspiration (FNA) and pleural fluid cytology diagnosis of benign metastasizing pleomorphic adenoma of the parotid gland in the lung: a case report and review of literature.
  • Lesions that contain abundant benign myoepithelial cells, including pleomorphic adenomas of salivary gland origin, may present a diagnostic challenge in fine-needle aspiration (FNA) specimens.
  • Benign metastasizing pleomorphic adenoma is a rare neoplasm, in which the benign appearing pleomorphic adenoma, without any histological evidence of malignancy, metastasizes to distant sites including lung.
  • In the absence of clinical history of a pre-existing myoepithelial neoplasm, the presence of myoepithelial cells in the lung or any other organs besides salivary glands may create diagnostic difficulty.
  • Here we present the cytologic findings of such a metastatic tumor found in the lung FNA and pleural fluid specimens from a 64-year-old woman, with a history of local recurrent salivary gland pleomorphic adenomas, who presented with multiple bilateral pulmonary nodules and pleural effusion.
  • The diagnosis of benign metastasizing pleomorphic adenoma was made based on clinical information and cytomorphology, and confirmed by immunocytochemistry.

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  • (PMID = 19582818.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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50. Suwała P, Wilczyński K, Barnaś S, Prudlak E: [A rare case of multiple primary benign neoplasm of parotid gland: oncocytoma and adenolimphoma]. Otolaryngol Pol; 2009 Sep;63(7):89-92
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  • [Title] [A rare case of multiple primary benign neoplasm of parotid gland: oncocytoma and adenolimphoma].
  • AIM OF THE WORK: The authors present unusually rare case primary multiple synchronicus benign tumor of the ipsilateral parotid gland: oncocytoma and Warthin's tumor, which is rare among occasionally occurred multiple tumors with different histology in the salivary glands.
  • MATERIAL AND METHOD: A 71-year-old man presented with the tumor in the right parotid gland.
  • We performed excision of the superficial lobe of the parotid gland.
  • The preoperative ultrasonography and macroscopic analysis of the removed parotid gland tissue revealed only one tumor recognised histopathologically as adenolimphoma, but upon histopathological examination Warthin's tumor proved to coexist with oncocytoma.
  • RESULTS AND CONCLUSIONS: In the ultrasonography examination some salivary glands tumors may not be recognised.
  • The histopathological examination is the ultimate method in recognising tumors, which are not detected in the preoperative diagnosis.
  • The superficial parotidectomy protects from the recrudescence of the superficial lobe of the parotid gland tumors.
  • The coexistence of the oncocytoma and Warthin's in one parotid gland is extremely rare.
  • [MeSH-minor] Aged. Humans. Male. Parotid Gland / pathology. Rare Diseases. Treatment Outcome

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  • (PMID = 20564910.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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51. Tilakaratne WM, Jayasooriya PR, Tennakoon TM, Saku T: Epithelial salivary tumors in Sri Lanka: a retrospective study of 713 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Jul;108(1):90-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelial salivary tumors in Sri Lanka: a retrospective study of 713 cases.
  • OBJECTIVE: The aim of this retrospective study was to evaluate the clinicopathologic data to determine the distribution of epithelial salivary tumors, especially minor salivary tumors, in Sri Lanka.
  • MATERIALS AND METHODS: A total of 713 salivary tumors diagnosed at the Department of Oral Pathology, during the period from 1990 to 2007 were reviewed.
  • RESULTS: Out of the 713 epithelial salivary tumors, 356 (49.9%) were classified as benign and 357 (50.1%) as malignant, indicating a benign-to-malignant ratio of 1:1.
  • The majority of both benign (29%) and malignant (39%) tumors occurred in the minor salivary glands.
  • Malignant tumors were slightly more common in minor salivary glands, indicating a benign-to-malignant ratio of 1:0.75.
  • Among the minor salivary sites, palate was the most frequent location, accounting for 51% of the tumors (246 out of 486).
  • Pleomorphic adenoma was the most frequent tumor, representing 38% of all tumors (274 out of 713), followed by mucoepidermoid carcinoma 21.6% (154 out of 713) and adenoid cystic carcinoma 13.5% (96 out of 713).
  • The commonest benign and malignant tumors were pleomorphic adenoma and mucoepidermoid carcinoma in both major and minor salivary glands.
  • CONCLUSION: According to the findings of this study, equal frequencies of benign and malignant tumors indicate higher occurrences of malignancies, especially in the minor salivary glands, in the Sri Lankan population.
  • [MeSH-major] Neoplasms, Glandular and Epithelial / epidemiology. Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adenolymphoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Adult. Age Factors. Aged. Aged, 80 and over. Carcinoma / epidemiology. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Mucoepidermoid / epidemiology. Female. Humans. Male. Middle Aged. Palatal Neoplasms / epidemiology. Parotid Neoplasms / epidemiology. Retrospective Studies. Salivary Glands, Minor / pathology. Sex Factors. Sri Lanka / epidemiology

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  • (PMID = 19403317.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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52. Bernabé DG, Veronese LA, Miyahara GI, Conrado-Neto S, Biasoli ER: Gingival metastasis from salivary duct carcinoma of the parotid gland. J Periodontol; 2008 Apr;79(4):748-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gingival metastasis from salivary duct carcinoma of the parotid gland.
  • BACKGROUND: This article reports a rare case of metastasis of salivary duct carcinoma of the parotid gland to the gingiva and reviews the occurrence of metastatic processes to the oral mucosa.
  • The intraoral examination revealed a reddish, superficially ulcerated nodular lesion ( approximately 2 cm in diameter) on the right mandibular buccal attached gingiva, and the clinical aspect was that of a benign reactive lesion.
  • The patient had undergone a parotidectomy for removal of a salivary duct carcinoma of the parotid gland almost 1 year before.
  • RESULTS: The analysis of the histopathologic sections of the gingival lesion revealed histomorphologic characteristics very similar to those of the primary parotid gland tumor.
  • The definitive diagnosis was gingival metastasis from a salivary duct carcinoma of the parotid gland.
  • The patient died of complications of a pulmonary metastasis 1 month after the diagnosis of the oral metastatic lesion.
  • CONCLUSIONS: Gingival lesions that mimic reactive and hyperplastic lesions may be metastases from malignant neoplasias of diverse origins.
  • An accurate and timely diagnosis is crucial to establish proper and immediate treatment of the metastatic tumor and possibly identify an occult primary malignant neoplasia.
  • [MeSH-major] Carcinoma, Ductal / secondary. Gingival Neoplasms / secondary. Parotid Neoplasms / pathology. Salivary Ducts / pathology

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  • (PMID = 18380570.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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53. Weinreb I, Seethala RR, Perez-Ordoñez B, Chetty R, Hoschar AP, Hunt JL: Oncocytic mucoepidermoid carcinoma: clinicopathologic description in a series of 12 cases. Am J Surg Pathol; 2009 Mar;33(3):409-16
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  • Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy.
  • The differential diagnosis of OMEC includes numerous oncocytic/"oncocytoid" neoplasms.
  • Some are benign while others are aggressive.
  • Recent evidence suggests that p63 is a reliable marker in the diagnosis of conventional MEC but has not been explored in OMEC.
  • Most occurred in the parotid (9) with 1 each in the sublingual gland, hard palate and neck.
  • All 6 cases tested showed the majority of oncocytic cells staining with p63 in a diffuse pattern, demonstrating its utility in the diagnosis of OMEC.
  • In summary, OMEC behaves as a low-grade tumor, and is diffusely positive for p63, which may aid in its differential diagnosis.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Mucoepidermoid / pathology. Membrane Proteins / biosynthesis. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 18971778.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Membrane Proteins
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54. Lourenço SV, Lima DM: Pleomorphic adenoma and adenoid cystic carcinoma: in vitro study of the impact of TGFbeta1 on the expression of integrins and cytoskeleton markers of cell differentiation. Int J Exp Pathol; 2007 Jun;88(3):191-8
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  • Pleomorphic adenoma (PA) and adenoid cystic carcinoma (ACC) are the commonest benign and malignant salivary gland tumours respectively.
  • PA cells showed increased expression of integrins and de novo expression of differentiation markers upon TGFbeta1 stimulation.
  • This may reflect important differences in the biological behaviour of benign and malignant cells.
  • [MeSH-minor] Adult. Antigens, CD29 / analysis. Antigens, CD29 / metabolism. Antigens, Differentiation / analysis. Cell Differentiation / drug effects. Cell Proliferation / drug effects. Cytoskeleton / metabolism. Enzyme-Linked Immunosorbent Assay / methods. Female. Fluorescent Antibody Technique. Humans. Integrin beta3 / analysis. Integrin beta3 / metabolism. Integrin beta4 / analysis. Integrin beta4 / metabolism. Middle Aged. Stimulation, Chemical. Tumor Cells, Cultured

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  • (PMID = 17504449.001).
  • [ISSN] 0959-9673
  • [Journal-full-title] International journal of experimental pathology
  • [ISO-abbreviation] Int J Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD29; 0 / Antigens, Differentiation; 0 / Integrin beta3; 0 / Integrin beta4; 0 / Integrins; 0 / Transforming Growth Factor beta1
  • [Other-IDs] NLM/ PMC2517303
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55. Takahama A Jr, León JE, de Almeida OP, Kowalski LP: Nonlymphoid mesenchymal tumors of the parotid gland. Oral Oncol; 2008 Oct;44(10):970-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nonlymphoid mesenchymal tumors of the parotid gland.
  • Salivary gland tumors are uncommon and most of them are of epithelial origin.
  • 15 out of 19 were benign tumors, including 5 lymphangiomas, 5 neurofibromas, and one case each of schwannoma, lipoma, solitary fibrous tumor, meningioma and giant cell tumor.
  • Four malignant tumors were classified as rhabdomyosarcoma, fibrosarcoma, Langerhans cell histiocytosis and endodermal sinus tumor.
  • From the malignant cases, only the patient with fibrosarcoma died due the tumor, the other three are alive with no signs of recurrence.
  • In our series of 600 cases of parotid gland tumors, nonlymphoid mesenchymal tumors corresponded to 3.16% (19 cases; 15 benign and 4 malignant).
  • [MeSH-minor] Adolescent. Adult. Aged. Brazil. Child. Child, Preschool. Diagnosis, Differential. Endodermal Sinus Tumor / pathology. Female. Fibrosarcoma / pathology. Histiocytosis, Langerhans-Cell / pathology. Humans. Infant. Male. Middle Aged. Neurofibroma / pathology. Rhabdomyosarcoma / pathology. Young Adult

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  • (PMID = 18282791.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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56. Winnes M, Mölne L, Suurküla M, Andrén Y, Persson F, Enlund F, Stenman G: Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas. Genes Chromosomes Cancer; 2007 Jun;46(6):559-63
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  • MECT1, TORC1, or WAMTP1) to the Notch coactivator MAML2 is a characteristic feature of low-grade mucoepidermoid carcinomas of salivary and bronchial glands.
  • Here we show that the CRTC1-MAML2 gene fusion is also frequent in benign hidradenomas of the skin.
  • Immunohistochemical analysis demonstrated expression of the fusion protein in the majority of tumor cells, including clear cells, poroid cells, and cells with epidermoid and ductal differentiation.
  • Our findings thus demonstrate that the CRTC1-MAML2 gene fusion is frequent in hidradenomas and is associated with clear cell variants of this tumor.
  • Taken together, the present and previous observations indicate that the CRTC1-MAML2 fusion is etiologically linked to benign and low-grade malignant tumors originating from diverse exocrine glands rather than being linked to a separate tumor entity.
  • [MeSH-major] Adenoma, Sweat Gland / genetics. Adenoma, Sweat Gland / metabolism. Oncogene Proteins, Fusion / metabolism. Sweat Gland Neoplasms / genetics. Sweat Gland Neoplasms / metabolism

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17334997.001).
  • [ISSN] 1045-2257
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MECT1-MAML2 fusion protein, human; 0 / Oncogene Proteins, Fusion
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57. Neves Cde O, Soares AB, Costa AF, de Araujo VC, Furuse C, Juliano PB, Altemani A: CD10 (Neutral Endopeptidase) Expression in Myoepithelial Cells of Salivary Neoplasms. Appl Immunohistochem Mol Morphol; 2010 Mar;18(2):172-8
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  • [Title] CD10 (Neutral Endopeptidase) Expression in Myoepithelial Cells of Salivary Neoplasms.
  • In salivary glands, expression of CD10 has only been used to identify neoplastic myoepithelial cells of pleomorphic adenomas and myoepithelial carcinomas.
  • However, its accuracy in other salivary tumors with myoepithelial component has yet to be analyzed.
  • We examined 72 salivary tumors with myoepithelial differentiation using immunohistochemical technique to detect CD10.
  • In salivary glands, CD10 expression was not detected in myoepithelial cells.
  • In neoplastic myoepithelial cells, CD10 expression was found in 25.71% of benign and 32.43% of malignant neoplasms.
  • In conclusion, salivary neoplastic myoepithelial cells gain CD10 expression in relation to their normal counterparts.
  • The high expression of CD10 by this carcinoma can be a valuable tool to separate EMEC from the tubular variant of adenoid cystic carcinomas in small incisional biopsies, where the precise diagnosis may be impossible.

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  • (PMID = 19752720.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ACTA2 protein, human; 0 / Actins; 0 / Biomarkers, Tumor; EC 3.4.24.11 / Neprilysin
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58. He ZX, Li YN, Liu LK, He HW, Wang D: [Expression of deltaNp63 in salivary gland tumours]. Sichuan Da Xue Xue Bao Yi Xue Ban; 2006 Jan;37(1):126-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Expression of deltaNp63 in salivary gland tumours].
  • OBJECTIVE: To detect the expression of deltaNp63 in human salivary gland tumor and analyze its role in the malignant salivary gland tumors.
  • METHODS: Collecting the samples from 68 cases of pathologically proven salivary gland tumours and investigating the microscopic sections with HE stain and immunohistochemical-SP stain.
  • RESULTS: It was found that the expression of deltaNp63 is gradually increased in the malignant tumours, the myoepithelial cells and the basal cells of the salivary gland tumors are positive, and the expression of deltaNp63 is correlated directly with benign and malignant tumor.
  • CONCLUSION: deltaNp63 plays an important role in salivary gland tumours. deltaNp63 possesses some special activity that is characteristic of oncogene. p63 is a sensitive and highly specific marker of myoepithelial cells in salivary gland tumours and an additional marker for defining myoepithelial histogenesis. p63 is of definite clinical value in falicitating diagnosis and differential diagnosis.
  • [MeSH-major] Cystadenocarcinoma / metabolism. DNA-Binding Proteins / biosynthesis. Myoepithelioma / metabolism. Salivary Gland Neoplasms / metabolism. Trans-Activators / biosynthesis. Tumor Suppressor Proteins / biosynthesis
  • [MeSH-minor] Adenoma, Pleomorphic / metabolism. Adenoma, Pleomorphic / pathology. Biomarkers, Tumor / biosynthesis. Humans. Immunohistochemistry. Transcription Factors

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  • (PMID = 16468660.001).
  • [ISSN] 1672-173X
  • [Journal-full-title] Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
  • [ISO-abbreviation] Sichuan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins
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59. Weiler C, Reu S, Zengel P, Kirchner T, Ihrler S: Obligate basal cell component in salivary oncocytoma facilitates distinction from acinic cell carcinoma. Pathol Res Pract; 2009;205(12):838-42
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  • [Title] Obligate basal cell component in salivary oncocytoma facilitates distinction from acinic cell carcinoma.
  • The differential diagnosis between benign salivary oncocytoma (ONC) and low-grade malignant acinic cell carcinoma (ACC) can be difficult due to a significant histomorphological overlap of the structural and cytological presentation of both tumor types.
  • To the best of our knowledge a comprehensive study comparing (immuno-)histological markers in cases of difficult differential diagnosis between ONC and ACC has not yet been performed.
  • The statistically significant stronger expression of CK7 in ONC and stronger expression of PAS and alpha-amylase in ACC in routine practice each is hampered by a pronounced overlap between both tumor groups.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Biomarkers, Tumor / analysis. Carcinoma, Acinar Cell / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratin-5 / analysis. Keratin-6 / analysis. Male. Middle Aged. Predictive Value of Tests. Trans-Activators / analysis. Transcription Factors. Tumor Suppressor Proteins / analysis

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  • (PMID = 19646823.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / KRT5 protein, human; 0 / Keratin-5; 0 / Keratin-6; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins
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60. Cohen D, Bhattacharyya I: Case of the month. Canalicular adenoma (benign salivary gland tumor). Todays FDA; 2008 Jun;20(6):13-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Case of the month. Canalicular adenoma (benign salivary gland tumor).
  • [MeSH-major] Adenoma / diagnosis. Lip Neoplasms / diagnosis. Salivary Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male

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  • (PMID = 18700293.001).
  • [ISSN] 1048-5317
  • [Journal-full-title] Today's FDA : official monthly journal of the Florida Dental Association
  • [ISO-abbreviation] Todays FDA
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Herce-López J, Salazar-Fernández CI, Mayorga-Jiménez F, Gallana-Alvarez S, Pérez-Sánchez JM: Synchronous unilateral parotid neoplasms. A case report. Med Oral Patol Oral Cir Bucal; 2009 Feb;14(2):E90-2
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  • The parotid gland is the most usual location of benign neoplasms affecting major salivary glands and quite often the recurrence of these tumours is noticed, specially in the case of pleomorphic adenoma.
  • The simultaneous development of tumours with different histological types is unusual and when it occurs, the most common combination is a pleomorphic adenoma and a Warthin's tumor.
  • The report describes a 55 year old female with a pleomorphic adenoma occurring synchronously with a Warthin's tumor within the superficial lobe of her left parotid gland.

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  • (PMID = 19179956.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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62. Behzatoglu K, Bahadir B, Huq GE, Kaplan HH: Spontaneous infarction of a pleomorphic adenoma in parotid gland: diagnostic problems and review. Diagn Cytopathol; 2005 Jun;32(6):367-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spontaneous infarction of a pleomorphic adenoma in parotid gland: diagnostic problems and review.
  • Although infarction of parotid gland pleomorphic adenoma (PA) following fine-needle aspiration (FNA) has been well-documented, spontaneous infarction of PA has remained as an uncommon entity in the literature.
  • To our knowledge, we report the second case of spontaneous infarction occurring in a parotid gland PA.
  • Although appears to be rare, spontaneous infarction of PA should be considered in the differential diagnosis, since necrosis may mimic carcinoma and cause misinterpretation of necrosis as an indication of malignancy, in an otherwise benign salivary gland neoplasm.
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Humans. Male. Parotid Gland / blood supply. Parotid Gland / pathology

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  • (PMID = 15880698.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Arathi N, Bage AM: Polymorphous low-grade adenocarcinoma of parotid gland: a rare occurrence. Indian J Pathol Microbiol; 2009 Jan-Mar;52(1):103-5
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  • [Title] Polymorphous low-grade adenocarcinoma of parotid gland: a rare occurrence.
  • Polymorphous low-grade adenocarcinoma (PLGA) is a rare salivary gland malignant tumor of low aggressiveness, commonly occurring in minor salivary glands.
  • Its occurrence in major salivary gland has been documented albeit rarely.
  • The striking histological feature is architectural diversity combined with benign cytologic features.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Parotid Gland / pathology. Parotid Neoplasms / diagnosis. Parotid Neoplasms / pathology

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  • [CommentIn] Indian J Pathol Microbiol. 2010 Jan-Mar;53(1):166-7 [20090256.001]
  • (PMID = 19136798.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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64. Alba García JR, Armengot Carceller M, Zapater Latorre E, Pérez Valles A, Basterra Alegría A: Malignant fibrohistiocytoma of the parotid region. Report of a case. Med Oral Patol Oral Cir Bucal; 2008 Feb;13(2):E148-50
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  • Most salivary gland tumors are benign, malignant lesions accounting for 15-30% of the total.
  • The most frequent site of salivary gland neoplasms is the parotid gland (80% of all cases).
  • Generally, this type of tumor arises in the lower limbs and in the abdomen.
  • When located in the parotid gland, these lesions appear as a firm, slow growing and painless mass.
  • The definitive diagnosis requires microscopic study of the resection piece using immunohistochemical techniques.
  • The success of treatment is dependent upon complete resection of the tumor - long term follow-up being necessary due to the risk of recurrence or distant metastasis.

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  • (PMID = 18223534.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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65. Daniel E, McGuirt WF Sr: Neck masses secondary to heterotopic salivary gland tissue: a 25-year experience. Am J Otolaryngol; 2005 Mar-Apr;26(2):96-100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neck masses secondary to heterotopic salivary gland tissue: a 25-year experience.
  • OBJECTIVES: The aim of this study is to review salivary tumors arising from heterotopic salivary inclusions in the periparotid and cervical lymph nodal tissues over a 25-year span.
  • METHODS: A retrospective chart review revealed 24 patients with asymptomatic neck masses treated between 1976 and 2001, whose pathology demonstrated heterotopic salivary tissue or neoplasms arising from heterotopic salivary tissue.
  • RESULTS: Nine cases were benign periparotid lymph nodes with heterotopic salivary inclusions, 3 of which had multimodal involvement.
  • Fifteen cases of heterotopic salivary tumors were identified.
  • The benign tumors were predominantly Warthin's tumor (8) with 1 pleomorphic adenoma.
  • Among the 15 tumor patients, follow-up ranged from 1 month to 17 years.
  • CONCLUSIONS: Heterotopic salivary tissue in periparotid and upper cervical nodes is a more common occurrence than historically recognized.
  • Tumorigenic changes arise from heterotopic nodal inclusions, and although infrequent, should be considered in the differential diagnosis for isolated neck/periparotid masses and parotid Warthin's tumor.
  • Suggested management, after a thorough clinical exam/needle aspiration biopsy, includes an imaging survey of the parotid gland and neck lymphatics with an appropriate resection to include a simple excision, parotidectomy, neck dissection, and/or irradiation as indicated.
  • Isolated low-grade malignant lesions/benign lesions are adequately managed by excision or parotidectomy alone.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Pleomorphic / pathology. Choristoma / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands

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  • (PMID = 15742261.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. Matsushima N, Maeda M, Takamura M, Takeda K: Apparent diffusion coefficients of benign and malignant salivary gland tumors. Comparison to histopathological findings. J Neuroradiol; 2007 Jul;34(3):183-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Apparent diffusion coefficients of benign and malignant salivary gland tumors. Comparison to histopathological findings.
  • OBJECTIVE: To evaluate the apparent diffusion coefficient (ADC) of benign and malignant salivary gland tumors in comparison to histopathological findings.
  • MATERIALS AND METHODS: This study included 32 patients with a wide spectrum of major salivary gland tumors (17 benign, 15 malignant).
  • Comparisons were made of mean ADC values between benign and malignant tumors, and among tumors showing different degrees of extracellular components.
  • RESULTS: Mean ADC values were 1.09+/-0.34 x 10(-3) mm(2)/s in malignant salivary gland tumors and 1.40+/-0.43 x 10(-3) mm(2)/s in benign salivary gland tumors.
  • No significant difference in mean ADC values was found between benign and malignant tumors (P>0.05).
  • Mean ADC values were significantly different between mild and moderate degrees (P<0.05) of extracellular components, and between mild and conspicuous degrees (P<0.05), in both benign and malignant tumor groups.
  • CONCLUSION: In this study, ADC values alone did not allow differentiation between benign and malignant salivary gland tumors.
  • Comparison with histopathological findings suggests a correlation between the amount of extracellular components and mean ADC values in salivary gland tumors.
  • [MeSH-major] Magnetic Resonance Imaging. Salivary Gland Neoplasms / metabolism. Salivary Gland Neoplasms / pathology

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  • (PMID = 17568674.001).
  • [ISSN] 0150-9861
  • [Journal-full-title] Journal of neuroradiology. Journal de neuroradiologie
  • [ISO-abbreviation] J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
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67. Doğan S, Can IH, Unlü I, Süngü N, Gönültaş MA, Samim EE: Sialolipoma of the parotid gland. J Craniofac Surg; 2009 May;20(3):847-8
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  • [Title] Sialolipoma of the parotid gland.
  • The clinical impression was that of a benign salivary gland tumor.
  • The tumor was situated in the superficial lobe of the gland, and a superficial parotidectomy was performed, with preservation of the facial nerve.
  • Histopathologic examination results revealed a sialolipoma of the parotid gland and a lesion that consisted of both mature adipose tissue and glandular elements.
  • Sialolipomas share similar clinical features with conventional lipomas of the salivary glands.
  • Preoperative diagnosis is generally difficult, and computed tomographic scanning is useful in defining these benign parotid gland masses.
  • Superficial parotidectomy is the usual surgical treatment for parotid gland superficial lobe lipomas, with near-total absence of recurrence.
  • [MeSH-major] Lipoma / diagnosis. Parotid Neoplasms / diagnosis
  • [MeSH-minor] Adipose Tissue / pathology. Adult. Diagnosis, Differential. Humans. Male. Parotid Gland / pathology

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  • (PMID = 19390452.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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68. Takahama A Jr, da Cruz Perez DE, Magrin J, de Almeida OP, Kowalski LP: Giant pleomorphic adenoma of the parotid gland. Med Oral Patol Oral Cir Bucal; 2008 Jan;13(1):E58-60
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  • [Title] Giant pleomorphic adenoma of the parotid gland.
  • Pleomorphic adenoma is the most common type of all benign and malignant salivary gland tumors, involving more frequently the parotid gland.
  • It is a benign tumor with a slow and continuous growth that without treatment can reach an enormous size.
  • We present a case of a giant pleomorphic adenoma in a 78-year-old man with a history of more than 30 years of a growing lesion in the parotid gland.
  • The tumor was completely resected by total parotidectomy and preservation of the facial nerve.
  • Macroscopically, the tumor measured 28 cm and weighed 4.0 Kg.

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  • (PMID = 18167483.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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69. Laikui L, Hongwei L, Hongbing J, Zhixiu H: Epithelial salivary gland tumors of children and adolescents in west China population: a clinicopathologic study of 79 cases. J Oral Pathol Med; 2008 Apr;37(4):201-5
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  • [Title] Epithelial salivary gland tumors of children and adolescents in west China population: a clinicopathologic study of 79 cases.
  • OBJECTIVE: Determine the clinical and histopathologic features of epithelial salivary gland tumors of children and adolescents.
  • METHODS: A total of 79 cases of epithelial salivary gland tumors of children and adolescents were retrieved from the files.
  • RESULTS: Sixty tumors (75.9%) were benign and 19 (24.1%) malignant.
  • The most common tumor overall was pleomorphic adenoma (PA).
  • PA was the most common type of benign tumor.
  • The most common malignant tumor was mucoepidermoid carcinoma.
  • One patient with mucoepidermoid carcinoma showed local recurrences and died from the tumor 3 years after the initial treatment.
  • CONCLUSIONS: Our data showed that the salivary gland tumors in children and adolescents may be the higher incidence of benign tumors, especially of PA; the slightly higher tendency for female predominance; the higher incidence of parotid glands.
  • Mucoepidermoid carcinoma was the most common malignant tumor, with majority of low grade.
  • Initial treatment should be planned to excise the tumor completely with satisfactory margins.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma, Mucoepidermoid / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 18205745.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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70. Ren WH, Zhi KQ, Gao L, Xu Y, Li XQ, Shi MJ: [Clinical utilization of veiled incision and sternocleidomastoid flap in parotidectomy of parotid benign tumors]. Shanghai Kou Qiang Yi Xue; 2010 Jun;19(3):232-5
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  • [Title] [Clinical utilization of veiled incision and sternocleidomastoid flap in parotidectomy of parotid benign tumors].
  • Postoperative complications included temporary facial paralysis and salivary fistula.
  • There was no significant difference between these two groups in temporary facial paralysis, salivary fistula, tumor recurrence, Frey's syndrome, the feeling of the region around the auricular lobule.
  • [MeSH-major] Parotid Gland. Sweating, Gustatory

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  • (PMID = 20635029.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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71. Martins C, Fonseca I, Roque L, Pereira T, Ribeiro C, Bullerdiek J, Soares J: PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using chromosome banding, in situ hybridization and immunocytochemistry. Mod Pathol; 2005 Aug;18(8):1048-55
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  • [Title] PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using chromosome banding, in situ hybridization and immunocytochemistry.
  • Pleomorphic adenoma is the most common benign tumor of the salivary glands.
  • In this study, we evaluated PLAG1 involvement in salivary gland tumorigenesis by determining the frequency of its alterations in a selected group of 20 salivary gland tumors: 16 pleomorphic adenomas and four carcinomas ex-pleomorphic adenoma, having in common the presence of karyotypic chromosome 8 deviations, either structural, with 8q12 rearrangements, or numerical, with gain of chromosome 8.
  • This finding further supports the pluripotent single-cell theory, which postulates that the tumor-initiated, modified myoepithelial cell, evolves into the varied somatic cell phenotypes present in pleomorphic adenoma, and reinforces the role of PLAG1 on the tumorigenesis of benign and malignant pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. DNA-Binding Proteins / genetics. Salivary Gland Neoplasms / pathology

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  • (PMID = 15920557.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / PLAG1 protein, human
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72. França SR, Caldas D, Alcebíades V 2nd, de Oliveira CA: [Mucoepidermoid carcinoma of the thyroid: a case report and literature review]. Arq Bras Endocrinol Metabol; 2006 Oct;50(5):968-76
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  • [Transliterated title] Carcinoma mucoepidermóide de tireóide: relato de caso e revisão da literatura.
  • The mucoepidermoid carcinoma is a neoplasia that usually occurs at salivary glands, breast, pancreas and gastrointestinal tract.
  • The primary occurrence on thyroid gland is rare and only 33 cases were previously published.
  • Although the majority of cases of mucoepidermoid carcinoma of the thyroid (MECT) show a benign evolution, this paper describes a patient with an aggressive tumor.
  • [MeSH-minor] Calcitonin / analysis. Female. Humans. Middle Aged. Mucins / metabolism. Neoplasm Recurrence, Local / pathology. Prognosis. Thyroid Gland / pathology. Thyroidectomy. Whole Body Imaging

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  • (PMID = 17160225.001).
  • [ISSN] 0004-2730
  • [Journal-full-title] Arquivos brasileiros de endocrinologia e metabologia
  • [ISO-abbreviation] Arq Bras Endocrinol Metabol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Mucins; 9007-12-9 / Calcitonin
  • [Number-of-references] 26
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73. Zare-Mahmoodabadi R, Salehinejad J, Saghafi S, Ghazi N, Mahmoudi P, Harraji A: Sebaceous adenoma of the submandibular gland: a case report. J Oral Sci; 2009 Dec;51(4):641-4
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  • [Title] Sebaceous adenoma of the submandibular gland: a case report.
  • Sebaceous adenoma of the salivary gland is a rare tumor comprising 0.1% of all salivary gland neoplasms and less than 0.5% of salivary adenomas.
  • Histologically, sebaceous adenomas are benign neoplasms consisting of sebaceous cells arranged in nests forming acinar and duct-like structures.
  • We describe a case of sebaceous adenoma in the submandibular gland.
  • Under a presumptive diagnosis of sialadenitis/sialolithiasis, the patient was administered multiple courses of antibiotics; however, these were not effective.
  • Excisional biopsy resulted in a diagnosis of sebaceous adenoma.
  • [MeSH-major] Adenoma / pathology. Submandibular Gland Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 20032620.001).
  • [ISSN] 1880-4926
  • [Journal-full-title] Journal of oral science
  • [ISO-abbreviation] J Oral Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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74. Veeresh M, Bavle RM, Vinay KN, Nandakumar H: Basal cell adenoma of the submandibular gland. J Maxillofac Oral Surg; 2010 Sep;9(3):289-91
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  • [Title] Basal cell adenoma of the submandibular gland.
  • Basel cell adenoma is a benign epithelial salivary gland tumor that appears to have unique histologic characteristics.
  • The diagnosis of this entity must be established by histological study.
  • It commonly occurs in parotid gland and very rarely in submandibular gland.
  • Here we report a case of basel cell adenoma of submandibular gland.

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  • (PMID = 22190808.001).
  • [ISSN] 0974-942X
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3177454
  • [Keywords] NOTNLM ; Adenoma / Basal cells / Submandibular gland
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75. Elagoz S, Gulluoglu M, Yilmazbayhan D, Ozer H, Arslan I: The value of fine-needle aspiration cytology in salivary gland lesions, 1994-2004. ORL J Otorhinolaryngol Relat Spec; 2007;69(1):51-6
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  • [Title] The value of fine-needle aspiration cytology in salivary gland lesions, 1994-2004.
  • OBJECTIVE: Fine-needle aspiration cytology (FNAC) of the salivary gland is a commonly accepted, sensitive and specific technique in the diagnosis of both neoplastic and nonneoplastic lesions of the salivary gland.
  • The aim of this study was to investigate the efficacy of FNAC of salivary gland lesions and to decide whether the radiologist could perform it or not.
  • METHODS: We aspirated 162 salivary gland lesions of 56 patients undergoing biopsy and excision.
  • RESULTS: In the present study, among the FNAC performed in 162 patients with salivary gland masses, 15 (9%) were inadequate, and the remaining 147 were diagnostic.
  • With FNAC 45 of the neoplastic lesions were benign and 13 malignant tumors.
  • When cytohistopathological correlation was performed, the overall accuracy in diagnosing benign and malignant lesions was 91 and 78%, respectively, except for 2 malignant lymphoma cases.
  • The sensitivity and specificity for benign and malignant lesions were 72 and 100%, respectively.
  • There was 1 false-positive result, in which a nonneoplastic lesion was misdiagnosed as a Warthin's tumor.
  • CONCLUSION: FNAC is a useful and reliable tool in the diagnosis of salivary gland masses when performed by a radiologist or a clinician.
  • [MeSH-major] Biopsy, Fine-Needle. Salivary Gland Diseases / diagnosis. Salivary Glands / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Infant. Male. Middle Aged. Salivary Gland Neoplasms / diagnosis. Sensitivity and Specificity

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  • [Copyright] Copyright (c) 2007 S. Karger AG, Basel.
  • (PMID = 17085953.001).
  • [ISSN] 0301-1569
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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76. Yih WY, Kratochvil FJ, Stewart JC: Intraoral minor salivary gland neoplasms: review of 213 cases. J Oral Maxillofac Surg; 2005 Jun;63(6):805-10
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  • [Title] Intraoral minor salivary gland neoplasms: review of 213 cases.
  • PURPOSE: Minor salivary gland tumors (MSGTs) constitute a heterogeneous group of neoplasms with great histomorphologic variation.
  • This study reviews a large series of benign and malignant salivary gland tumors of the oral region and determines the incidence and the correlation of the histopathologic features with the clinical characteristics.
  • RESULTS: One hundred nineteen tumors were benign (56%), and 94 tumors were malignant (44%).
  • Pleomorphic adenoma was the most common benign tumor (93 of 119).
  • Canalicular adenoma was the second most common benign MSGT in our series (25 of 119).
  • CONCLUSIONS: Benign intraoral MSGTs are slightly more common than malignant MSGTs.
  • The palate is the most common site for minor gland neoplasms.
  • Benign labial salivary gland neoplasms are more common in the upper lip, and malignant labial tumors are more common in the lower lip.
  • [MeSH-major] Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • (PMID = 15944978.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Singh S, Shivamurthy DM, Agarwal R: Pleomorphic adenoma of the soft palate. J Maxillofac Oral Surg; 2010 Mar;9(1):76-7
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  • Pleomorphic adenoma is the commonest benign salivary gland tumour, accounting for almost three fourths of all such tumours.
  • Pleomorphic adenoma most commonly occurs in the parotid gland; however it is also encountered in the submandibular, sublingual and minor salivary glands.Almost half of all salivary gland tumours are malignant, pleomorphic adenoma is the commonest benign lesion.A case of pleomorphic adenoma arising denovo in the minor salivary glands is discussed.

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  • [Cites] Oral Surg Oral Med Oral Pathol. 1988 Sep;66(3):323-33 [2845326.001]
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  • (PMID = 23139574.001).
  • [ISSN] 0972-8279
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3453680
  • [Keywords] NOTNLM ; Minor salivary gland tumours / Pleomorphic adenoma
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78. Ganly I, Gross ND, Patel SG, Bilsky MH, Shah JP, Kraus DH: Outcome of craniofacial resection in patients 70 years of age and older. Head Neck; 2007 Feb;29(2):89-94
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  • Thirty-five patients had a malignant tumor and 1 patient a benign tumor; 15 (42%) had high-grade, 17 (47%) intermediate-grade, and 4 (11%) low-grade pathology.
  • [MeSH-major] Nose Neoplasms / surgery. Postoperative Complications. Salivary Gland Neoplasms / surgery. Skull Base Neoplasms / surgery
  • [MeSH-minor] Age Factors. Aged. Aged, 80 and over. Carcinoma / mortality. Carcinoma / pathology. Carcinoma / surgery. Cranial Fossa, Anterior / surgery. Cranial Fossa, Middle / surgery. Databases as Topic. Esthesioneuroblastoma, Olfactory / mortality. Esthesioneuroblastoma, Olfactory / pathology. Esthesioneuroblastoma, Olfactory / surgery. Female. Follow-Up Studies. Humans. Male. Melanoma / mortality. Melanoma / pathology. Melanoma / surgery. Neoplasm Recurrence, Local. Prospective Studies. Surgical Flaps. Survival Analysis


79. Chawla S, Kim S, Wang S, Poptani H: Diffusion-weighted imaging in head and neck cancers. Future Oncol; 2009 Sep;5(7):959-75
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  • This article reviews the utility of diffusion-weighted imaging (DWI) in the diagnosis, prognosis and monitoring of treatment response in tumors arising in the head and neck region.
  • The ADC value also discriminates carcinomas from lymphomas, benign lesions from malignant tumors and tumor necrosis from abscesses.
  • These promising reports indicate the potential of DWI as a potential biomarker for diagnosis and monitoring of treatment response in head and neck cancers.
  • In view of the overlapping ADC values between different salivary gland tumors, care should be taken when interpreting these results and other imaging parameters should be considered for a better diagnosis.

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  • (PMID = 19792966.001).
  • [ISSN] 1744-8301
  • [Journal-full-title] Future oncology (London, England)
  • [ISO-abbreviation] Future Oncol
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA102756-04; United States / NCI NIH HHS / CA / R01 CA102756; United States / NCI NIH HHS / CA / R01 CA102756-04; United States / NCI NIH HHS / CA / R01-CA102756
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] England
  • [Number-of-references] 115
  • [Other-IDs] NLM/ NIHMS155262; NLM/ PMC2791671
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80. Ellis GL: Lymphoid lesions of salivary glands: malignant and benign. Med Oral Patol Oral Cir Bucal; 2007 Dec;12(7):E479-85
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  • [Title] Lymphoid lesions of salivary glands: malignant and benign.
  • Lesions of salivary glands with a prominent lymphoid component are a heterogeneous group of diseases that include benign reactive lesions and malignant neoplasms.
  • Occasionally, these pathologic entities present difficulties in the clinical and pathological diagnosis and prognosis.
  • Lymphoepithelial sialadenitis, HIV-associated salivary gland disease, chronic sclerosing sialadenitis, Warthin tumor, and extranodal marginal zone B-cell lymphoma are examples of this pathology that are sometimes problematic to differentiate from one another.
  • [MeSH-major] Salivary Gland Diseases. Salivary Gland Neoplasms
  • [MeSH-minor] Adenolymphoma / diagnosis. Carcinoma / diagnosis. Humans. Lymphoma, B-Cell, Marginal Zone / diagnosis. Prognosis. Sialadenitis / diagnosis

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  • (PMID = 17978770.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 30
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81. Al-Khateeb TH, Ababneh KT: Salivary tumors in north Jordanians: a descriptive study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 May;103(5):e53-9
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  • [Title] Salivary tumors in north Jordanians: a descriptive study.
  • OBJECTIVE: To evaluate the types and distribution of tumors of salivary glands in north Jordanians.
  • STUDY DESIGN: The records of the Department of Pathology at Jordan University of Science and Technology were reviewed for patients who were treated for salivary gland tumors from 1991 to 2002.
  • The tumors were analyzed for age of patient, sex of patient, tumor site, and tumor type.
  • RESULTS: One hundred two true neoplasms (70% benign and 30% malignant) were found.
  • The most frequent benign and malignant neoplasms found were pleomorphic adenoma (54%) and adenoid cystic carcinoma (13%), respectively.
  • The most common major and minor salivary gland sites were the parotid (51%) and palatal glands (20%), respectively.
  • Although most of major gland tumors were adenomas, carcinomas of the minor glands were only slightly less frequent than adenomas.
  • The most frequent minor salivary gland malignant tumors were palatal adenoid cystic carcinoma.
  • CONCLUSION: North Jordanians with salivary gland tumors were found to have similar characteristics with patients of other countries with regard to tumor type, tumor site distribution, and age and sex of patients.
  • [MeSH-major] Adenoma, Pleomorphic / epidemiology. Carcinoma, Adenoid Cystic / epidemiology. Salivary Gland Neoplasms / epidemiology

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  • (PMID = 17368055.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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82. Debnath SC, Adhyapok AK: Pleomorphic adenoma (benign mixed tumour) of the minor salivary glands of the upper lip. J Maxillofac Oral Surg; 2010 Jun;9(2):205-8
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  • [Title] Pleomorphic adenoma (benign mixed tumour) of the minor salivary glands of the upper lip.
  • Pleomorphic adenoma is the benign tumor of salivary glands, which originates from the myoepithelial cells and intercalated duct cells.
  • This tumor is more common in major salivary glands.
  • This case report describes a rare and unusual lesion in a 55-year-old female, which was diagnosed as pleomorphic adenoma of the minor salivary glands in the upper lip.
  • The tumor was a circumscribed, submucosal nodule, about 2.0 cm in diameter and was characterized by slow growth and rubbery consistency.
  • Complete excision was performed and the histopathological analysis showed an epithelial salivary gland tumor with islands of plasmacytoid cells, duct like structures, in a variable stroma with chondroid, fibrous and myxoid appearance.

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  • (PMID = 22190789.001).
  • [ISSN] 0974-942X
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3244097
  • [Keywords] NOTNLM ; Minor salivary glands / Pleomorphic adenoma / Upper lip
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83. Testa D, Galera F, Insabato L, Vassallo A, Mesolella M, Galli V: Submandibular gland myoepithelioma. Acta Otolaryngol; 2005 Jun;125(6):664-6
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  • [Title] Submandibular gland myoepithelioma.
  • Benign myoepithelioma is a very rare form of salivary gland tumor, composed entirely of myoepithelial cells.
  • It accounts for approximately 1% of all salivary gland tumors and is most frequently located in the parotid gland and in the minor salivary glands of the hard palate.
  • We describe herein the ninth reported case of myoepithelioma of the submandibular gland.
  • Benign myoepithelioma must be differentiated from several benign and malignant epithelial and mesenchymal tumors.
  • [MeSH-major] Myoepithelioma / pathology. Submandibular Gland Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 16076718.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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84. Baradaranfar MH, Dabirmoghaddam P: Endoscopic endonasal surgery for resection of benign sinonasal tumors: experience with 105 patients. Arch Iran Med; 2006 Jul;9(3):244-9
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  • [Title] Endoscopic endonasal surgery for resection of benign sinonasal tumors: experience with 105 patients.
  • OBJECTIVE: To report our experience with endoscopic surgery of benign tumors and tumor-like conditions of the nose and paranasal sinuses.
  • METHODS: The medical records of 105 patients with benign sinonasal tumor, who had undergone endoscopic surgery for removal of their neoplasm between 1997 and 2003, were retrospectively studied.
  • RESULTS: The studied patients included 32 with juvenile nasopharyngeal angiofibroma, 24 with inverted papilloma, 23 with benign fibroosseous lesions, 18 with pyogenic granuloma, 6 with intranasal hemangioma, and 2 with pleomorphic adenoma.
  • Eight cases of recurrent tumor--2 angiofibroma, 4 inverted papilloma, 1 fibrous dysplasia, and 1 osteoma--were noted and managed endoscopically alone or in combination with Caldwell-Luc approach.
  • CONCLUSION: Endoscopic surgery is a valuable tool for removal of benign tumors of the nose and paranasal sinuses in the hands of an experienced surgeon.
  • [MeSH-major] Endoscopy / methods. Nasopharyngeal Neoplasms / surgery. Paranasal Sinus Neoplasms / surgery. Salivary Gland Neoplasms / surgery
  • [MeSH-minor] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / surgery. Adolescent. Adult. Aged. Angiofibroma / diagnosis. Angiofibroma / surgery. Child. Diagnosis, Differential. Female. Follow-Up Studies. Hemangioma / diagnosis. Hemangioma / surgery. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Papilloma, Inverted / diagnosis. Papilloma, Inverted / surgery. Retrospective Studies. Time Factors. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16859060.001).
  • [ISSN] 1029-2977
  • [Journal-full-title] Archives of Iranian medicine
  • [ISO-abbreviation] Arch Iran Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Iran
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85. Ilie M, Hofman V, Pedeutour F, Attias R, Santini J, Hofman P: Oncocytic lipoadenoma of the parotid gland: Immunohistochemical and cytogenetic analysis. Pathol Res Pract; 2010 Jan 15;206(1):66-72
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  • [Title] Oncocytic lipoadenoma of the parotid gland: Immunohistochemical and cytogenetic analysis.
  • Salivary gland oncocytic lipoadenoma is an exceptional benign tumor composed of mature adipose tissue associated with a mixture of oncocytes.
  • A 64-year-old male developed a left parotid gland, well-encapsulated tumor measuring 3.5 x 3 cm(2), showing mature fat cells associated with oncocytic changes of epithelial components.
  • Such alterations in HMGA2 have been described in both lipomas and pleomorphic adenomas of the salivary glands.
  • [MeSH-minor] Disease-Free Survival. Humans. Immunohistochemistry. Lipoma / metabolism. Lipoma / pathology. Lipoma / surgery. Male. Middle Aged. Neoplasm Proteins / metabolism

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  • [Copyright] Copyright 2009 Elsevier GmbH. All rights reserved.
  • (PMID = 19346081.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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86. Al-Rawi NH, Omer H, Al Kawas S: Immunohistochemical analysis of P(53) and bcl-2 in benign and malignant salivary glands tumors. J Oral Pathol Med; 2010 Jan;39(1):48-55
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  • [Title] Immunohistochemical analysis of P(53) and bcl-2 in benign and malignant salivary glands tumors.
  • BACKGROUND: Salivary glands tumors are relatively uncommon neoplasm with widely variable histopathologic and biologic characteristics.
  • Alteration in some proto-oncogenes and tumor suppressor genes may lead to the development and progression of these tumors.
  • AIMS: The purpose of this study was to analyze the immunohistochemical expression of P(53) and bcl-2 in some salivary gland tumors in relation to tumor size, histologic grade, and extent of invasion.
  • SETTING AND DESIGN: The sample consisted of 22 formalin-fixed paraffin embedded blocks of benign and malignant salivary glands tumors.
  • MATERIAL AND METHOD: P(53) and bcl-2 immunoreactivity was semi-quantitatively evaluated in at least 1000 cells examined under the microscope at 40x magnification and recorded as percentage of P(53) or bcl-2 positive tumor cells over the total number of cells examined in the same area.
  • RESULTS AND CONCLUSION: Pleomorphic adenoma (PA) showed negative expression of P(53) and bcl-2 in 70% of cases, whereas all malignant salivary glands tumors were positive for P(53) and bcl-2.
  • P(53)/bcl-2 immunostaining reactivity could be helpful in demonstrating salivary glands tumor behavior in terms of progression and extent of invasion.
  • [MeSH-major] Proto-Oncogene Proteins c-bcl-2 / analysis. Salivary Gland Neoplasms / pathology. Tumor Suppressor Protein p53 / analysis
  • [MeSH-minor] Adenocarcinoma / pathology. Adenoma, Pleomorphic / pathology. Adolescent. Adult. Aged. Carcinoma / pathology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / pathology. Cell Count. Female. Humans. Immunohistochemistry. Lymph Nodes / pathology. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Invasiveness. Neoplasms, Multiple Primary / pathology

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  • (PMID = 19761475.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53
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87. Betka J, Chovanec M, Klozar J, Taudy M, Plzák J, Kodetová D, Lisý J: Transoral and combined transoral-transcervical approach in the surgery of parapharyngeal tumors. Eur Arch Otorhinolaryngol; 2010 May;267(5):765-72
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  • The goal of parapharyngeal space (PPS) tumor surgery is to obtain adequate visualization to ensure complete removal with preservation of the surrounding nerves and vessels.
  • Transoral approach is the most controversial one due to cited limited exposure, risk of tumor spillage, and possibility of neurovascular injury.
  • Majority of treated tumors were pleomorphic adenomas (14 minor salivary gland and 7 deep lobe parotid gland tumors).
  • Two cases of malignant salivary gland tumors, 4 nerve sheath tumors and 1 lymphangioma were also excised.
  • Mean tumor size was 6.1 cm (range 2-11 cm).
  • It can be combined with external approach to achieve safe resection of some benign tumors which would need transmandibular approach.
  • [MeSH-minor] Female. Humans. Male. Mouth. Neck. Neoplasm Staging. Nerve Sheath Neoplasms / surgery. Salivary Gland Neoplasms / surgery

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  • (PMID = 19714351.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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88. Ozcan C, Apa DD, Vayisoglu Y, Görür K: Unilateral parotid gland involvement with synchronous multiple Basal cell adenomas. J Craniofac Surg; 2007 Nov;18(6):1470-3
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  • [Title] Unilateral parotid gland involvement with synchronous multiple Basal cell adenomas.
  • Basal cell adenoma (BCA) is a rare benign epithelial tumor of the salivary gland.
  • BCA is seen most frequently in the parotid gland and less commonly in the submandibular gland and minor glands of the upper lips, oral cavity, and hard palate.
  • Salivary gland tumors are observed as single tumors in one salivary gland.
  • Double or multiple tumors of the salivary gland tumors are unusual and metachronous or bilateral salivary gland tumors are more observed than synchronous or unilateral tumors.
  • The most commonly seen multiple tumor unilaterally or bilaterally is the Warthin's tumor.
  • Physical examination revealed two solid and well-delineated masses in the preauricular region, which were 1.5 x 1 cm in diameter and in the tail of the parotid gland, which is 2.5 x 2 cm in diameter.
  • Excision of the superficial lobe of the parotid gland was performed.
  • Multiple synchronous nonmembranous-type BCAs of the unilateral parotid gland is a rare entity.
  • More extensive excision of the parotid gland tumor, careful macroscopic perioperative examination of the surgical specimen, and histologic evaluation of all surgical specimens might be necessary for reducing revision operations and surgical complications.
  • [MeSH-minor] Adenolymphoma / diagnosis. Aged. Diagnosis, Differential. Female. Humans. Tomography, X-Ray Computed

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  • (PMID = 17993904.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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89. John BJ, Griffiths C, Ebbs SR: Pleomorphic adenoma of the breast should be excised with a cuff of normal tissue. Breast J; 2007 Jul-Aug;13(4):418-20
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  • Pleomorphic adenoma is a benign tumor found rarely in the breast but commonly in the salivary gland.
  • Unlike the salivary gland variant management guidelines are poorly defined in the breast.
  • Due to the risk of recurrence and malignant transformation, we recommend complete excision of the lesion with a cuff of normal tissue, as is the practice in the salivary gland.
  • Clinicians should be aware of the condition, as preoperative diagnosis will facilitate adequate surgery.
  • [MeSH-minor] Adult. Female. Humans. Neoplasm Recurrence, Local / surgery

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  • (PMID = 17593049.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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90. Wittekindt C, Burmeister HP, Guntinas-Lichius O: [Diagnostic and therapy of salivary gland diseases: relevant aspects for the pathologist from the clinical perspective]. Pathologe; 2009 Nov;30(6):424-31
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  • [Title] [Diagnostic and therapy of salivary gland diseases: relevant aspects for the pathologist from the clinical perspective].
  • [Transliterated title] Diagnostik und Therapie von Speicheldrüsenerkrankungen: Relevantes für den Pathologen aus Sicht der Klinik.
  • Significant progress in the diagnosis and therapy of salivary gland diseases has been made in recent years.
  • The number of open resections of salivary glands due to stones will clearly decrease in the future in favor of endoscopic removal.
  • Due to recent publications on the appropriate extent of salivary gland resection in benign tumors, more and more specimens with reduced cuffs of healthy salivary gland tissue will be sent to the pathologists.
  • Ultrasound will stay the procedure of first choice for imaging of salivary gland diseases in Germany.
  • In combination with fine-needle aspiration cytology high sensitivity and specificity for the assessment of salivary gland tumors can be achieved.
  • The use of botulinum toxin for salivary glands diseases is increasing.
  • Intraglandular injections have been shown to induce salivary gland atrophy in animal experiments.
  • [MeSH-major] Salivary Gland Neoplasms / diagnosis. Sjogren's Syndrome / diagnosis
  • [MeSH-minor] AIDS-Related Opportunistic Infections / diagnosis. AIDS-Related Opportunistic Infections / pathology. AIDS-Related Opportunistic Infections / therapy. Biomarkers, Tumor / analysis. Cell Proliferation. Cell Transformation, Neoplastic / pathology. Cysts / pathology. Diagnosis, Differential. Epithelium / pathology. Humans. Keratins / analysis. Lymph Nodes / pathology. Lymphoma, B-Cell, Marginal Zone / diagnosis. Lymphoma, B-Cell, Marginal Zone / pathology. Lymphoma, B-Cell, Marginal Zone / therapy. Parotid Diseases / diagnosis. Parotid Diseases / pathology. Parotid Diseases / therapy. Salivary Ducts / pathology. Salivary Glands / pathology. Sialadenitis / diagnosis. Sialadenitis / pathology

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  • (PMID = 19756611.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
  • [Number-of-references] 28
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91. Apple SK, Moatamed NA, Lai CK, Bhuta S: Sebaceous adenoma of the parotid gland: a case report with fine needle aspiration findings and histologic correlation. Acta Cytol; 2009 Jul-Aug;53(4):419-22
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  • [Title] Sebaceous adenoma of the parotid gland: a case report with fine needle aspiration findings and histologic correlation.
  • BACKGROUND: Sebaceous adenoma of the salivary gland is an extremely rare, benign neoplasm that predominantly involves the major salivary glands.
  • CONCLUSION: We report a case ofa rare and unusual tumor of the salivary glands.

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  • (PMID = 19697727.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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92. He H, Chen G, Zhou L, Liu Y: A joint detection of CEA and CA-50 levels in saliva and serum of patients with tumors in oral region and salivary gland. J Cancer Res Clin Oncol; 2009 Oct;135(10):1315-21
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  • [Title] A joint detection of CEA and CA-50 levels in saliva and serum of patients with tumors in oral region and salivary gland.
  • OBJECTIVE: To detect the levels of carcinoembryonic antigen (CEA) and carcinoma associated antigen CA-50 in the patients with oral or salivary malignant tumors.
  • METHODS: The concentrations of salivary CEA and CA-50 were assayed in 80 patients of oral and salivary malignant tumors, 40 patients of benign tumors and 80 health controls.
  • RESULTS: Salivary CEA and CA-50 levels were significantly higher in malignant tumors than in benign tumors and in health controls, respectively (P < 0.001).
  • This may be more useful as prognostic indicators in early diagnosis of oral and salivary malignant tumors.
  • [MeSH-major] Adenoma / blood. Antigens, Tumor-Associated, Carbohydrate / analysis. Carcinoembryonic Antigen / analysis. Mouth Neoplasms / blood. Saliva / chemistry. Salivary Gland Neoplasms / blood
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Case-Control Studies. Enzyme-Linked Immunosorbent Assay. Female. Humans. Immunoradiometric Assay. Male. Middle Aged. Neoplasm Staging. Prognosis. Survival Rate. Young Adult

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  • (PMID = 19322585.001).
  • [ISSN] 1432-1335
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, Tumor-Associated, Carbohydrate; 0 / CA-50 antigen; 0 / Carcinoembryonic Antigen
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93. Sit KY, Chui WH, Wang E, Chiu SW: Multiple pulmonary metastases from benign pleomorphic adenoma. Asian Cardiovasc Thorac Ann; 2008 Jan;16(1):62-4
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  • [Title] Multiple pulmonary metastases from benign pleomorphic adenoma.
  • Metastasizing pleomorphic adenoma is a rare condition of metastasis from a histologically benign salivary gland tumor.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Incidental Findings. Lung Neoplasms / secondary. Neoplasm Recurrence, Local. Salivary Gland Neoplasms / pathology

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  • (PMID = 18245710.001).
  • [ISSN] 1816-5370
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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94. Tiwari A, Kini H, Pai RR, Rau AR: HIV lymphadenitis of the salivary gland: A case with cytological and histological correlation. J Cytol; 2009 Oct;26(4):146-8
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  • [Title] HIV lymphadenitis of the salivary gland: A case with cytological and histological correlation.
  • Human immunodeficiency virus infection associated lymphadenitis of the salivary glands (HIVLSG) and benign lymphoepithelial cysts are described as early events in HIV patients.
  • The diagnosis is not usually made clinically as it mimics a salivary gland tumor.
  • The cytological diagnosis was florid reactive lymphoid hyperplasia.
  • Histopathology revealed features of HIVLSG with multiple, small, cystic, benign lymphoepithelial lesions.

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  • (PMID = 21938179.001).
  • [ISSN] 0974-5165
  • [Journal-full-title] Journal of cytology
  • [ISO-abbreviation] J Cytol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3168000
  • [Keywords] NOTNLM ; Benign lymphoepithelial cyst / HIV/AIDS lymphadenitis / lymphoid hyperplasia of salivary glands
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95. Mendenhall WM, Mendenhall CM, Werning JW, Malyapa RS, Mendenhall NP: Salivary gland pleomorphic adenoma. Am J Clin Oncol; 2008 Feb;31(1):95-9
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  • [Title] Salivary gland pleomorphic adenoma.
  • We discuss the optimal treatment and outcomes for pleomorphic adenoma of the salivary glands by reviewing the pertinent literature.
  • Pleomorphic adenoma is the most common benign salivary gland neoplasm.
  • It is found mostly in the parotid gland in middle-aged women.
  • Local control rates after RT for microscopic and gross residual tumor are approximately 80% to 85% and 40% to 60%, respectively.
  • [MeSH-major] Adenoma, Pleomorphic / therapy. Neoplasm Recurrence, Local / diagnosis. Salivary Gland Neoplasms / therapy


96. Nepal A, Chettri ST, Joshi RR, Bhattarai M, Ghimire A, Karki S: Primary salivary gland tumors in eastern Nepal tertiary care hospital. J Nepal Health Res Counc; 2010 Apr;8(1):31-4
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  • [Title] Primary salivary gland tumors in eastern Nepal tertiary care hospital.
  • BACKGROUND: The knowledge of the distribution and pattern of salivary gland tumors in the tertiary care center can provide overview of the disease pattern in the region.
  • METHODS: A retrospective observational study of all the salivary gland tumors treated in the department of Otolaryngology, B. P.
  • Age, sex, presenting features, radiological findings, histopathological type of the tumor and type of surgery were recorded and descriptive analysis was done to calculate frequencies, percentage and their relations.
  • RESULTS: Out of total 51 cases, 81% (n=41) were benign and 19% (n=10) malignant tumors.
  • Mean age for benign and malignant tumors were 32.3 and 46.5 years respectively.
  • Parotid tumor outnumbered all other sites comprising 69%, followed by submandiibular 18% and minor glands 13%.
  • Pleomorphic adenoma was the commonest tumor (76%) of all primary salivary gland tumors.
  • Benign to malignant tumor ratio of parotid, submandibular and minor glands were 6:1, 3.5:1 and 1.3:1 respectively.
  • CONCLUSIONS: The principal site for salivary gland tumors in eastern Nepal population was the parotid and the pleomorphic adenoma outnumbered all other tumors.
  • Most of the cases in both benign and malignant group presented with painless lump often misleading the gravity of disease.
  • [MeSH-major] Salivary Gland Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / pathology. Female. Humans. Male. Middle Aged. Nepal. Parotid Gland / pathology. Parotid Neoplasms / diagnosis. Parotid Neoplasms / pathology. Retrospective Studies. Salivary Glands / pathology. Young Adult

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  • (PMID = 21879011.001).
  • [ISSN] 1999-6217
  • [Journal-full-title] Journal of Nepal Health Research Council
  • [ISO-abbreviation] J Nepal Health Res Counc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nepal
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97. Alcure ML, Della Coletta R, Graner E, Di Hipolito O Jr, Lopes MA: Sialolithiasis of minor salivary glands: a clinical and histopathological study. Gen Dent; 2005 Jul-Aug;53(4):278-81
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  • [Title] Sialolithiasis of minor salivary glands: a clinical and histopathological study.
  • Sialolithiasis is one of the most common disorders of particular major salivary glands.
  • It is caused by sialolith within the ducts or parenchyma of particularly major salivary glands.
  • Although sialolithasis is not uncommon, it often is clinically misdiagnosed when minor salivary glands are affected.
  • This article describes the clinical and microscopic findings of nine cases of sialolithiasis of minor salivary glands.
  • The most common clinical hypotheses for diagnosis were mucocele, sialoadenitis, and benign salivary gland tumor.
  • Sialolithiasis of minor salivary glands was misdiagnosed frequently.
  • It should be considered as a possible diagnosis when swelling of the oral tissues is observed.
  • [MeSH-major] Salivary Gland Calculi / pathology. Salivary Glands, Minor / pathology
  • [MeSH-minor] Adult. Aged. Cheek. Diagnosis, Differential. Female. Humans. Lip. Male. Middle Aged. Mouth Mucosa

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  • (PMID = 16158797.001).
  • [ISSN] 0363-6771
  • [Journal-full-title] General dentistry
  • [ISO-abbreviation] Gen Dent
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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98. Woo VL, Angiero F, Fantasia JE: Myoepithelioma of the tongue. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2005 May;99(5):581-9
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  • Soft tissue myoepitheliomas, in contrast to salivary gland myoepitheliomas, are benign neoplasms that typically occur in the soft tissues of the extremities.
  • A histologically similar lesion that has a marked predilection for the anterior dorsum of the tongue has been referred to as ectomesenchymal chondromyxoid tumor.
  • We present a case of myoepithelioma of the tongue and review the literature, with emphasis on the differential diagnosis and histogenesis of this lesion and pertinent nosologic considerations.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratins / analysis. Membrane Proteins / analysis. S100 Proteins / analysis

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  • (PMID = 15829881.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / Membrane Proteins; 0 / S100 Proteins; 68238-35-7 / Keratins
  • [Number-of-references] 30
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99. Dickson PV, Davidoff AM: Malignant neoplasms of the head and neck. Semin Pediatr Surg; 2006 May;15(2):92-8
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  • Having a working knowledge of lesions within this region and conducting a thorough history and physical examination generally enables the clinician to facilitate an appropriate workup and establish a diagnosis.
  • The differential diagnosis is broad, and expeditiously distinguishing benign from malignant masses is critical for instituting a timely multidisciplinary approach to the management of malignant lesions.
  • A diagnosis of malignancy may represent a primary tumor or metastatic foci to cervical nodes.
  • Thyroid, parathyroid, and salivary gland tumors are discussed elsewhere in this issue of Seminars in Pediatric Surgery.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / therapy
  • [MeSH-minor] Child. Diagnosis, Differential. Humans. Lymph Nodes / anatomy & histology. Lymphatic Diseases / diagnosis. Lymphatic Diseases / therapy. Lymphoma / diagnosis. Lymphoma / therapy. Neck. Neuroblastoma / diagnosis. Neuroblastoma / therapy. Rhabdomyosarcoma / diagnosis. Rhabdomyosarcoma / therapy

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  • (PMID = 16616312.001).
  • [ISSN] 1055-8586
  • [Journal-full-title] Seminars in pediatric surgery
  • [ISO-abbreviation] Semin. Pediatr. Surg.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA 21765
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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100. Zarka MA: Epithelioid cell clusters with an extensive lymphoid background. Arch Pathol Lab Med; 2007 Mar;131(3):424-33
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  • CONTEXT: Fine-needle aspiration of salivary gland lesions can be particularly challenging for pathologists.
  • OBJECTIVE: To present and discuss a practical pattern recognition approach to fine-needle aspiration diagnosis, which includes categorizing lesions that share a certain overall cytologic architectural pattern, followed by identifying unique cellular characteristics that are specific to a certain lesion.
  • An extensive discussion of one cytologic common pattern of salivary gland lesions, "epithelioid cell clusters with an extensive lymphoid background," is presented.
  • CONCLUSIONS: A practical cytologic architectural pattern method can aid the pathologist in rendering a correct diagnosis when evaluating salivary gland lesions.
  • One common pattern in salivary gland cytopathology is epithelioid cell clusters with an extensive lymphoid background.
  • This pattern is often associated with Warthin tumor; however, other benign and malignant entities fall under this diagnostic group.
  • [MeSH-major] Salivary Gland Neoplasms / pathology. Salivary Glands / pathology

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  • (PMID = 17516744.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 31
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