[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Items 1 to 100 of about 142
1. Sebag P, Tourasse C, Rouyer N, Lebas P, Dénier JF, Michenet P: [Value of vacuum assisted biopsies under sonography guidance: results from a multicentric study of 650 lesions]. J Radiol; 2006 Jan;87(1):29-34
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lesions were categorized, using the classification from Stavros, between "probably benign", "indeterminate", "probably malignant" and "malignant" Histology was validated only after review of the clinical and radiological data, as well as surgical data when available.
  • All benign cases were included in an on-going follow-up protocol.
  • RESULTS: We have identified 471 benign lesions and 179 malignant lesions.
  • Three cancers were diagnosed in the cases of "probably benign lesions" and in the cases of "probably malignant lesions" 18 (27%) were inflammatory disorders.
  • Specificity is excellent with no cancer detected so far among the patients with benign findings, under follow-up.
  • [MeSH-major] Biopsy, Needle / methods. Breast / pathology. Ultrasonography, Interventional. Ultrasonography, Mammary
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Breast Neoplasms / pathology. Breast Neoplasms / ultrasonography. Carcinoma in Situ / pathology. Carcinoma, Ductal, Breast / pathology. Diagnosis, Differential. Female. Fibroadenoma / pathology. Follow-Up Studies. Humans. Hyperplasia. Middle Aged. Minimally Invasive Surgical Procedures. Papilloma / pathology. Phyllodes Tumor / pathology. Retrospective Studies. Sensitivity and Specificity. Vacuum

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16415777.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Multicenter Study
  • [Publication-country] France
  •  go-up   go-down


2. Mannan AA, Kahvic M, Aziz AH: Phyllodes tumor of the vulva: Report of a rare case and review of the literature. Am J Dermatopathol; 2010 Jun;32(4):384-6
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phyllodes tumor of the vulva: Report of a rare case and review of the literature.
  • Phyllodes tumor occurring in the vulva is extremely rare; only 6 cases have been previously reported in the literature.
  • The histogenetic origin of this tumor is controversial as it is being debated whether such lesions evolve from ectopic breast tissue, cutaneous apocrine glands, and most recently, anogenital mammary-like gland.
  • Microscopic examination revealed morphologic pattern characteristic of benign phyllodes tumor.
  • We also discuss the histogenesis of phyllodes tumor and related lesions occurring in the anogenital region in light of the current literature along with a brief review of the previously reported cases of vulvar phyllodes tumor.
  • [MeSH-major] Phyllodes Tumor / pathology. Vulvar Neoplasms / pathology

  • Genetic Alliance. consumer health - Phyllodes Tumor.
  • MedlinePlus Health Information. consumer health - Vulvar Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20514681.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
  • [Number-of-references] 11
  •  go-up   go-down


3. Anyikam A, Nzegwu MA, Ozumba BC, Okoye I, Olusina DB: Benign breast lesions in Eastern Nigeria. Saudi Med J; 2008 Feb;29(2):241-4
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign breast lesions in Eastern Nigeria.
  • OBJECTIVE: To characterize benign breast diseases in Eastern Nigeria and to highlight the age variations of these lesions as base line data.
  • Seven hundred and twenty-two benign breast specimens were analyzed over 5 years from 1st January 2000 to 31st December 2004, out of 1050 breast samples received.
  • RESULTS: Of 1050 breast specimens received, 722 (68.8%) were benign.
  • Normal breast in the axillary tail region was seen in 32 cases (4.4%), represented as no pathology, with a mean presentation age of 20-46 years.
  • Low grade Phyllodes tumor had 28 cases (3.9%), presenting at an average mean age of 17-32 years.
  • Benign breast lesions peaked at the 20-24 age range and then declined.
  • CONCLUSION: Benign breast lesions occur more frequently than malignant breast lesions with a ratio of 2.3:1 and were presented 20 years earlier than their malignant counterparts.
  • Fibroadenoma was the most common benign lesion followed by fibrocystic disease, similar to the findings in Western Nigeria.
  • In Northern Nigeria, fibrocystic breast disease was more common.
  • [MeSH-major] Breast Diseases / epidemiology. Breast Neoplasms / epidemiology. Fibroadenoma / epidemiology
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Child. Female. Fibrocystic Breast Disease / epidemiology. Gynecomastia / epidemiology. Humans. Male. Middle Aged. Nigeria / epidemiology. Phyllodes Tumor / epidemiology. Sex Factors

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • MedlinePlus Health Information. consumer health - Breast Diseases.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18246234.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Saudi Arabia
  •  go-up   go-down


Advertisement
4. Abdalla HM, Sakr MA: Predictive factors of local recurrence and survival following primary surgical treatment of phyllodes tumors of the breast. J Egypt Natl Canc Inst; 2006 Jun;18(2):125-33
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Predictive factors of local recurrence and survival following primary surgical treatment of phyllodes tumors of the breast.
  • BACKGROUND AND PURPOSE: The phyllodes tumor is characterized by its tendency to recur locally and occasionally to metastasize.
  • Local recurrence and death from metastases are occasional, but consistent, theme in reports of patients with phyllodes tumors (PTs).
  • The aim of this study was to determine parameters that influence outcome in this uncommon neoplasm.
  • PATIENTS AND METHODS: Data from 79 patients with phyllodes tumors were reviewed retrospectively, reclassifying the pathological material using the World Health Organization (WHO) criteria.
  • The tumor size ranged from 2.5 to 24 cm, with a median of 11 cm.
  • Based on the criteria proposed by WHO, 31 cases were benign tumors (39.2%), 27 borderline tumors (34.2%), and 21 malignant tumors (26.6%).
  • Following local excision, the local recurrence rates were 14.3%, 50%, and 75% in patients with benign, borderline, and malignant tumors; respectively, while after wide local excision the local recurrence rates were 0%, 36.3% and 40%; respectively.
  • Whereas, 0%, 8.3%, and 8.3% of patients with benign, borderline and malignant tumors; respectively, locally recurred after mastectomy.
  • Distant metastases developed in 3.2%, 11.1%, and in 28.6% of patients with benign, borderline and malignant tumors; respectively.
  • The 5-year survival with no evidence of disease was 90% for the patients with benign tumors compared to 69% for borderline and 61% for malignant PTs (p= 0.02).
  • CONCLUSIONS: The histotype of phyllodes tumors and resection margins were the principal determinants of local recurrence and distant metastases.
  • Complete surgical excision by either wide local excision or mastectomy if necessary is important in the primary surgical treatment of phyllodes tumors.
  • [MeSH-major] Breast Neoplasms / pathology. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / mortality. Phyllodes Tumor / pathology

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17496937.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  •  go-up   go-down


5. Cîmpean AM, Raica M, Nariţa D: Diagnostic significance of the immunoexpression of CD34 and smooth muscle cell actin in benign and malignant tumors of the breast. Rom J Morphol Embryol; 2005;46(2):123-9
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic significance of the immunoexpression of CD34 and smooth muscle cell actin in benign and malignant tumors of the breast.
  • PURPOSE: Our aim was to investigate the distribution of CD34 and smooth muscle cell actin positive myofibroblasts in the stroma of the normal mammary gland, benign and malignant tumors.
  • METHODS: Our study included 112 female patients with suspect breast masses obtained by surgery or biopsy.
  • RESULTS: We have found normal breast tissue, sclerosing adenosis, fibroadenomas, fibrocystic diseases, phyllodes tumor, DCIS, ductal invasive, lobular, squamous, medullary, mucinous, and papillary carcinomas.
  • All the normal breast tissues and most of benign lesions were positive for CD34 and negative for SMA.
  • The exceptions were represented by a case of fibroadenoma and the phyllodes tumor, with CD34 positivity and a focal acquisition of SMA; fibrocystic disease with associated apocrine metaplasia adjacent to a squamous carcinoma with loss of CD34 expression and focal acquisition of SMA.
  • CONCLUSIONS: Although there were some exceptions especially when one of the two markers was interpreted separately and in some cases associated with sclerotic stroma, we conclude that the combined expression of CD34 and a-SMA is of potential diagnostic value in the distinction between benign and malignant tumors in some difficult cases.
  • [MeSH-major] Actins / analysis. Antigens, CD34 / analysis. Breast Neoplasms / pathology. Muscle, Smooth / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, CD / analysis. Biopsy. Carcinoma, Ductal / pathology. Female. Fibrocystic Breast Disease / pathology. Humans. Middle Aged. Neoplasm Invasiveness. Smad Proteins / analysis

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16286998.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD; 0 / Antigens, CD34; 0 / Smad Proteins
  •  go-up   go-down


6. Fajdić J, Gotovac N, Hrgović Z, Kristek J, Horvat V, Kaufmann M: Phyllodes tumors of the breast diagnostic and therapeutic dilemmas. Onkologie; 2007 Mar;30(3):113-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phyllodes tumors of the breast diagnostic and therapeutic dilemmas.
  • BACKGROUND: This article compares experiences in the diagnosis and treatment of phyllodes tumors from 2 regional institutions with the relevant literature.
  • PATIENTS AND METHODS: From 1991 to 2005, 2,848 breast cancer patients were treated in our institutions, 36 (1.44%) for phyllodes tumors.
  • The average tumor size was 5.1 cm (range 1.4-19.6).
  • Wide excision with tumor-free margins was carried out in 29 (80.5%) cases and mastectomy in 7 (19.4%) cases.
  • RESULTS: Histology showed the phyllodes tumors to be benign in 27 (75.0%), malignant in 6 (16.6%), and borderline in 3 (8.3%) cases.
  • In this period, recurrences of 3 (8.3%) malignant and 2 (5.6%) benign phyllodes tumors were diagnosed and treated.
  • CONCLUSION: Our study shows that tumor size, margin infiltration, mitotic activity and degree of cellular atypia are important prognostic factors.
  • Although wide local excision is usually the treatment of choice, tumor recurrence is common.
  • Axillary lymphadenectomy in malignant phyllodes tumors is, in our opinion, still controversial.
  • [MeSH-major] Breast Neoplasms / diagnosis. Phyllodes Tumor / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Breast / pathology. Diagnosis, Differential. Female. Humans. Lymph Node Excision. Lymph Nodes / pathology. Lymphatic Metastasis / pathology. Mammography. Mastectomy. Mastectomy, Segmental. Middle Aged. Mitotic Index. Necrosis. Neoplasm Invasiveness / pathology. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Prognosis. Reoperation. Survival Rate

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17341897.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  •  go-up   go-down


7. Djordjevic B, Hanna WM: Expression of c-kit in fibroepithelial lesions of the breast is a mast cell phenomenon. Mod Pathol; 2008 Oct;21(10):1238-45
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of c-kit in fibroepithelial lesions of the breast is a mast cell phenomenon.
  • The expression of c-kit, a protooncogene tyrosine kinase receptor (CD117), in phyllodes tumors of the breast has been the subject of recent investigations.
  • We examined stromal c-kit expression by immunohistochemistry in 68 cases comprising fibroadenomas, fibroadenomas with cellular stroma, and benign, borderline, and malignant phyllodes tumors.
  • One borderline and one malignant phyllodes tumor showed a diffuse weak stromal signal, which could not be accounted for by toluidine blue and tryptase.
  • Our findings indicate that c-kit is an unlikely player in the pathogenesis of fibroepithelial lesions of the breast.
  • C-kit, therefore, has neither a diagnostic nor a prognostic role in phyllodes tumors, and there is no rationale for the treatment of recurrent of malignant phyllodes tumor patients with tyrosine kinase inhibitors.
  • [MeSH-major] Breast Neoplasms / metabolism. Mast Cells / metabolism. Phyllodes Tumor / metabolism. Proto-Oncogene Proteins c-kit / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. DNA Mutational Analysis. DNA, Neoplasm / analysis. Female. Fibroadenoma / metabolism. Fibroadenoma / pathology. Humans. Immunohistochemistry. Mastectomy. Stromal Cells / metabolism. Stromal Cells / pathology

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18500266.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  •  go-up   go-down


8. Sönmez K, Türkyilmaz Z, Karabulut R, Demiroğullari B, Ozen IO, Moralioğlu S, Başaklar AC, Kale N: Surgical breast lesions in adolescent patients and a review of the literature. Acta Chir Belg; 2006 Jul-Aug;106(4):400-4
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical breast lesions in adolescent patients and a review of the literature.
  • BACKGROUND/PURPOSE: Breast disease in adolescence is uncommon, with most presenting lesions being benign.
  • Breast lesions in adolescent patients are discussed in this article with a review of world literature.
  • PATIENTS AND METHODS: The clinical records of 30 patients operated upon for breast lesions in our hospital during 18 years were reviewed.
  • Twenty-five female patients were operated on for breast mass and/or discharge, and five male adolescents were operated on for gynaecomastia.
  • The most frequent (n = 27) complaint was palpation of mass in the breast.
  • CONCLUSION: The most frequently encountered breast masses were fibro-adenomas.
  • These lesions are mostly benign in nature and can be treated conservatively but the possibility of precancerous lesion should be considered during follow-up.
  • [MeSH-major] Breast Diseases / surgery
  • [MeSH-minor] Adolescent. Breast Neoplasms / surgery. Child. Female. Fibroadenoma / surgery. Gynecomastia / surgery. Humans. Male. Nipples / pathology. Phyllodes Tumor / surgery

  • MedlinePlus Health Information. consumer health - Breast Diseases.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17017692.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 23
  •  go-up   go-down


9. Jara-Lazaro AR, Tan PH: Molecular pathogenesis of progression and recurrence in breast phyllodes tumors. Am J Transl Res; 2009;1(1):23-34
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular pathogenesis of progression and recurrence in breast phyllodes tumors.
  • Breast phyllodes tumors are rare fibroepithelial neoplasms that need to be distinguished from the common morphologically similar fibroadenomas, because phyllodes tumors can recur and progress to malignancy.
  • Their potentially recurring and metastasizing behavior is attributed to their stromal characteristics, for which categorization between benign, borderline and malignant tumors have not been universally established.
  • Previous clonality studies revealing monoclonal stromal cells versus a polyclonal epithelial component theorized that phyllodes tumors are mainly stromal neoplasms, possibly arising from fibroadenomas.
  • Inverse correlations between epithelial and stromal overexpression for various biological markers like estrogen receptor, p53, c-kit, Ki-67, endothelin-1, epidermal growth factor receptor, heparan sulfate, in addition to findings of epithelial Wnt signalling with stromal insulin growth factors and beta-catenin expression, suggest an initial epithelial-stromal interdependence at the benign phase.
  • Acquisition of new genetic imbalances within the tumor consistent with intratumoral heterogeneity, and subclones within histologically benign phyllodes tumors that recur or metastasize are the current theories explaining these tumors' unpredictable clinical behavior.

  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Hum Pathol. 2004 Sep;35(9):1053-7 [15343505.001]
  • [Cites] Mod Pathol. 2004 Jul;17(7):827-31 [15044924.001]
  • [Cites] Am J Clin Pathol. 2005 Apr;123(4):529-40 [15743740.001]
  • [Cites] Mod Pathol. 2005 Dec;18(12):1527-34 [16258510.001]
  • [Cites] Lab Invest. 2006 Jan;86(1):54-61 [16258523.001]
  • [Cites] Mod Pathol. 2006 Oct;19(10):1344-50 [16862076.001]
  • [Cites] Arch Pathol Lab Med. 2006 Oct;130(10):1516-21 [17090194.001]
  • [Cites] Mod Pathol. 2007 Apr;20(4):435-44 [17334353.001]
  • [Cites] J Pathol. 2008 Apr;214(5):533-44 [18288784.001]
  • [Cites] J Pathol. 2008 Dec;216(4):408-17 [18937276.001]
  • [Cites] Cancer. 1992 Oct 15;70(8):2115-20 [1327488.001]
  • [Cites] Cancer Res. 1993 Sep 1;53(17):4071-4 [8395336.001]
  • [Cites] Cancer. 1995 Nov 15;76(10):1779-85 [8625047.001]
  • [Cites] Histopathology. 1999 Jun;34(6):491-6 [10383692.001]
  • [Cites] Am J Pathol. 2000 Mar;156(3):1093-8 [10702425.001]
  • [Cites] J Surg Res. 2000 Dec;94(2):84-91 [11104647.001]
  • [Cites] Breast Cancer Res Treat. 2001 Jan;65(1):77-85 [11245343.001]
  • [Cites] Mod Pathol. 2001 Mar;14(3):185-90 [11266524.001]
  • [Cites] Histopathology. 2001 Jun;38(6):567-70 [11422501.001]
  • [Cites] J Pathol. 2002 Apr;196(4):437-44 [11920740.001]
  • [Cites] Am J Clin Pathol. 2002 Oct;118(4):522-6 [12375638.001]
  • [Cites] J Pathol. 2003 Aug;200(5):627-32 [12898599.001]
  • [Cites] J Clin Pathol. 2004 Oct;57(10):1075-9 [15452163.001]
  • (PMID = 19966935.001).
  • [ISSN] 1943-8141
  • [Journal-full-title] American journal of translational research
  • [ISO-abbreviation] Am J Transl Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2776292
  • [Keywords] NOTNLM ; Molecular pathogenesis / biological markers / epithelial-stromal interactions / genetic alterations / phyllodes tumors / subclones
  •  go-up   go-down


10. Abdallah A, Saklaoui O, Stückle C, Sommerer F, Hatzmann W, Audretsch W, Wesemann A, Zink M, Skoljarev L, Papadopoulos S: [Case reports of operative management of very large, benign phylloid tumors--is a safety margin necessary?]. Gynakol Geburtshilfliche Rundsch; 2009;49(4):320-5
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Case reports of operative management of very large, benign phylloid tumors--is a safety margin necessary?].
  • The phylloid tumor (PT, formerly called cystosarcoma phylloides) is a rare neoplasia of the female breast.
  • Usually the PT is treated with breast-conserving surgery.
  • In spite of progress in early diagnosis, PTs recur frequently--independently of tumor's degree of malignancy.
  • Especially in cases of malignant PT, complete resection with tumor-free margins is seen as the only predictive marker for tumor recurrence or metastases.
  • Benign PT is also often resected with wide tumor-free margins.
  • Because of the tumor's occasionally enormous dimensions, this therapy concept makes breast-conserving surgery almost impossible.
  • A simple enucleation of benign PT is an option to facilitate the preservation of breast tissue and a cosmetically satisfactory breast reconstruction.
  • In the case of particularly large benign PT, enucleation even without wide margins prevents tumor recurrence.
  • [MeSH-major] Breast Neoplasms / surgery. Mastectomy, Subcutaneous / methods. Phyllodes Tumor / surgery
  • [MeSH-minor] Adult. Biopsy, Needle. Breast / pathology. Esthetics. Female. Follow-Up Studies. Humans. Mammaplasty / methods. Mammography. Middle Aged. Ultrasonography, Mammary

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20530948.001).
  • [ISSN] 1423-0011
  • [Journal-full-title] Gynäkologisch-geburtshilfliche Rundschau
  • [ISO-abbreviation] Gynakol Geburtshilfliche Rundsch
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Switzerland
  •  go-up   go-down


11. Udapudi DG, Vasudeva P, Srikantiah R, Virupakshappa E: Massive benign phyllodes tumor. Breast J; 2005 Nov-Dec;11(6):521
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Massive benign phyllodes tumor.
  • [MeSH-major] Breast Neoplasms / pathology. Breast Neoplasms / surgery. Phyllodes Tumor / pathology. Phyllodes Tumor / surgery

  • Genetic Alliance. consumer health - Phyllodes Tumor.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16297126.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


12. Foxcroft LM, Evans EB, Porter AJ: Difficulties in the pre-operative diagnosis of phyllodes tumours of the breast: a study of 84 cases. Breast; 2007 Feb;16(1):27-37
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Difficulties in the pre-operative diagnosis of phyllodes tumours of the breast: a study of 84 cases.
  • Eighty-four phyllodes tumours (71 benign, eight borderline and five malignant) diagnosed over a 16-year period were studied retrospectively, to assess the diagnostic value of the pre-operative modalities used.
  • The possibility of phyllodes tumour was raised in only 23% on fine needle aspiration cytology, and in 65% on core biopsy.
  • For phyllodes tumours whose growth was measured, almost all had growth rates greater than for growing fibroadenomas.
  • The pre-operative diagnosis of phyllodes tumours is difficult, and rapid growth and/or large size of apparent fibroadenomas may be the only imaging findings to suggest phyllodes tumour.
  • Whole breast ultrasound showed that nearly one third of women with phyllodes tumours had concurrent fibroadenomas.
  • [MeSH-major] Breast Neoplasms / diagnosis. Phyllodes Tumor / diagnosis

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16876413.001).
  • [ISSN] 0960-9776
  • [Journal-full-title] Breast (Edinburgh, Scotland)
  • [ISO-abbreviation] Breast
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
  •  go-up   go-down


13. Wang ZC, Buraimoh A, Iglehart JD, Richardson AL: Genome-wide analysis for loss of heterozygosity in primary and recurrent phyllodes tumor and fibroadenoma of breast using single nucleotide polymorphism arrays. Breast Cancer Res Treat; 2006 Jun;97(3):301-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genome-wide analysis for loss of heterozygosity in primary and recurrent phyllodes tumor and fibroadenoma of breast using single nucleotide polymorphism arrays.
  • Phyllodes tumors of the breast are biphasic stromal and epithelial tumors histologically similar to benign fibroadenomas, but with a neoplastic stromal component.
  • In contrast to fibroadenoma, phyllodes tumors can recur and be locally aggressive or be malignant.
  • This study uses SNP array analysis to present a genome-wide map of loss of heterozygosity (LOH) in a cohort of phyllodes tumors and fibroadenomas.
  • LOH is frequent and sometimes extensive in phyllodes tumors, but is rarely seen in fibroadenomas.
  • There is heterogeneity between phyllodes tumors of different patients and no one LOH marker identifies a majority of these lesions.
  • However, a subset of LOH loci occur in multiple cases of phyllodes tumors and are not found in fibroadenomas.
  • Primary phyllodes tumors and paired recurrences from the same patient share common regions of LOH.
  • Specific LOH loci may be associated with pathologic progression in recurrent phyllodes tumors.
  • In a single case of phyllodes tumor containing a malignant epithelial component the malignant epithelium and stroma partially share an LOH genotype, suggesting a common precursor cell for the biphasic malignant components.
  • [MeSH-major] Breast Neoplasms / genetics. Fibroadenoma / genetics. Loss of Heterozygosity. Neoplasms, Multiple Primary / genetics. Neoplasms, Second Primary / genetics. Oligonucleotide Array Sequence Analysis. Phyllodes Tumor / genetics. Polymorphism, Single Nucleotide
  • [MeSH-minor] Cell Transformation, Neoplastic / genetics. DNA, Neoplasm / genetics. Epithelial Cells / pathology. Female. Gene Expression Profiling. Genome, Human. Humans. Stromal Cells / pathology

  • Genetic Alliance. consumer health - Phyllodes Tumor.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16791486.001).
  • [ISSN] 0167-6806
  • [Journal-full-title] Breast cancer research and treatment
  • [ISO-abbreviation] Breast Cancer Res. Treat.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / NCI P50 CA89393-01
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Neoplasm
  •  go-up   go-down


14. Moriya T, Kozuka Y, Kanomata N, Tse GM, Tan PH: The role of immunohistochemistry in the differential diagnosis of breast lesions. Pathology; 2009 Jan;41(1):68-76
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of immunohistochemistry in the differential diagnosis of breast lesions.
  • Immunohistochemistry may be helpful in the diagnosis of various breast lesions.
  • It can be used to assist in distinguishing benign and malignant conditions, or to clarify the histological subtype of invasive carcinomas.
  • High molecular weight cytokeratins (CK5/6, CK14, 34betaE12) typically show a mosaic-like pattern of expression in benign papillary/hyperplastic lesions, and are mostly negative in ductal in situ carcinoma, but some exceptions exist.
  • Cytokeratins, especially the antibody 34betaE12, are of value to differentiate spindle cell carcinoma from phyllodes tumour.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Breast Neoplasms / diagnosis. Breast Neoplasms / metabolism. Immunohistochemistry / methods


15. Villarreal-Colín SP, Soto-Dávalos BA, Bargalló-Rocha JE, Bandera-Delgado A, Zumaran-Cuéllar O, Robles-Vidal CD: [Breast fibromatosis: a lesion mimicking cancer]. Cir Cir; 2008 Mar-Apr;76(2):169-71
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Breast fibromatosis: a lesion mimicking cancer].
  • BACKGROUND: Breast fibromatosis (BF) is a rare benign pathological entity.
  • The patient was a 17-year-old female with a 20 x 15 cm firm and fixed mass in the right breast.
  • A core-needle biopsy was taken with a pathology report of a phyllodes tumor.
  • The patient was a 49-year-old female with a 7 x 5 cm solid right breast mass located at the medial-upper quadrant and fixed to the pectoralis major muscle.
  • Its clinical and imaging features can mimic breast cancer.
  • [MeSH-major] Breast Neoplasms / diagnosis. Fibroma / diagnosis


16. Granić M, Oprić D, Pupić G, Babić D, Ivanović N, Nikolić D, Dikić S, Oprić S: [Surgical methods for the treatment of breast phyllodes tumors--a report of 319 cases]. Acta Chir Iugosl; 2006;53(1):57-62
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Surgical methods for the treatment of breast phyllodes tumors--a report of 319 cases].
  • Breast phyllodes tumors (FT) belong the fibroapitelial group of breast tumors arising in terminal ductulo-lobular unit (TDLU).
  • Their incidence do not exceed 1% of all breast tumors.
  • Biologicaly they can be divided into benign, borderline and malignant group.
  • Incomplete tumor excision can be the reason for local reccurence.
  • METHODS: We analyzed histopathology features of 319 FT of the breast surgicaly removed on Departement of surgery Institut of oncology and radiology of Serbia between 1.1.1985.
  • -31.12.1994. Retrospective study of surgical treatment 84 patients with FT of the breast (69 benign, 4 borderline and 11 malignant) and 5 year follow up after surgery we analysed.
  • RESULTS: local reccurence after surgery was found in 17 (20,2 %) patients(14 benign , 2 borderline and 1 malignant FT), pulmonary metastases in 6 (7,1%) patients with malignant FT.
  • CONCLUSION: According to biological behavior we propose wide excision for benign and borderline forms and simple mastectomy for malignant FT, and voluminous benign and borderline forms.
  • [MeSH-major] Breast Neoplasms / surgery. Phyllodes Tumor / surgery
  • [MeSH-minor] Female. Humans. Neoplasm Recurrence, Local

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16989148.001).
  • [ISSN] 0354-950X
  • [Journal-full-title] Acta chirurgica Iugoslavica
  • [ISO-abbreviation] Acta Chir Iugosl
  • [Language] srp
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
  •  go-up   go-down


17. Bode MK, Rissanen T, Apaja-Sarkkinen M: Ultrasonography and core needle biopsy in the differential diagnosis of fibroadenoma and tumor phyllodes. Acta Radiol; 2007 Sep;48(7):708-13
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ultrasonography and core needle biopsy in the differential diagnosis of fibroadenoma and tumor phyllodes.
  • BACKGROUND: The diagnosis of phyllodes tumors of the breast is challenging due to many similarities with common fibroadenomas.
  • PURPOSE: To determine the diagnostic accuracy of core needle biopsy in diagnosing phyllodes tumors and to analyze the ultrasonographic (US) features of phyllodes tumors and fibroadenomas.
  • MATERIAL AND METHODS: From 1999 to 2003, 1010 breast lesions underwent imaging-guided core needle biopsy.
  • Of these, 57 fibroadenomas and 12 phyllodes tumors were removed surgically.
  • The US and needle biopsy results of a total of 64 lesions (52 fibroadenomas and 12 phyllodes tumors) were further analyzed, compared, and correlated with surgical histological results.
  • RESULTS: The median sonographic sizes of the phyllodes tumors and the fibroadenomas were 3.2 cm and 1.6 cm, respectively.
  • At US, 58% of the phyllodes tumors (7/12) were classified as equivocal or suspicious of malignancy and 42% (5/12) as probably benign, while 54% of the fibroadenomas (28/52) were classified as probably benign and 46% (24/52) as equivocal.
  • The sensitivity, specificity, and positive and negative predictive values of core needle biopsy histology regarding tumor phyllodes were 83%, 92%, 71%, and 96%, respectively.
  • CONCLUSION: Imaging-guided core needle biopsy was accurate in differentiating between fibroadenomas and phyllodes tumors.
  • Combined use of US feature analysis and needle biopsy may help to avoid the misinterpretation of phyllodes as fibroadenoma.
  • [MeSH-major] Breast Neoplasms / pathology. Breast Neoplasms / ultrasonography. Fibroadenoma / pathology. Fibroadenoma / ultrasonography. Phyllodes Tumor / pathology. Phyllodes Tumor / ultrasonography

  • Genetic Alliance. consumer health - Phyllodes Tumor.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17728999.001).
  • [ISSN] 0284-1851
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Sweden
  •  go-up   go-down


18. Tan PH: 2005 Galloway Memorial Lecture: Breast phyllodes tumours--morphology and beyond. Ann Acad Med Singapore; 2005 Dec;34(11):671-7
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] 2005 Galloway Memorial Lecture: Breast phyllodes tumours--morphology and beyond.
  • OBJECTIVES: The aims of this study were to evaluate the predictive role of morphology in a series of breast phyllodes tumours (PTs) in Asian women, and to determine the utility of immunohistochemical expression of p53 and CD117 in the stromal component.
  • MATERIALS AND METHODS: Breast PTs, diagnosed between January 1992 and December 2002 at the Department of Pathology, Singapore General Hospital, were classified into benign, borderline and malignant categories.
  • Histologic classification revealed 250 (74.6%) benign, 54 (16.1%) borderline and 31 (9.3%) malignant PTs.
  • CONCLUSIONS: Involved surgical margins remain a key prognostic parameter in breast PT.
  • [MeSH-major] Breast Neoplasms / pathology. Phyllodes Tumor / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Immunohistochemistry. Middle Aged. Neoplasm Recurrence, Local. Proto-Oncogene Proteins c-kit / analysis. Survival Rate. Tumor Suppressor Protein p53 / analysis

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16453039.001).
  • [ISSN] 0304-4602
  • [Journal-full-title] Annals of the Academy of Medicine, Singapore
  • [ISO-abbreviation] Ann. Acad. Med. Singap.
  • [Language] eng
  • [Publication-type] Lectures; Research Support, Non-U.S. Gov't
  • [Publication-country] Singapore
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  •  go-up   go-down


19. Huo L, Gilcrease MZ: Fibroepithelial lesions of the breast with pleomorphic stromal giant cells: a clinicopathologic study of 4 cases and review of the literature. Ann Diagn Pathol; 2009 Aug;13(4):226-32
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fibroepithelial lesions of the breast with pleomorphic stromal giant cells: a clinicopathologic study of 4 cases and review of the literature.
  • Pleomorphic stromal giant cells are occasionally found as an incidental finding in breast tissue but are only rarely seen in fibroepithelial lesions.
  • In this report, we describe 4 fibroadenoma-like lesions of the breast with pleomorphic stromal giant cells.
  • Two cases had focal stromal hypercellularity, one of which was with architectural features borderline between a fibroadenoma and a phyllodes tumor, but none was considered diagnostic of phyllodes tumor.
  • Follow-up for 3 cases at 16 to 59 months revealed no evidence of tumor recurrence.
  • It appears that the presence of pleomorphic stromal giant cells in an otherwise benign fibroepithelial lesion has no adverse clinical significance.
  • [MeSH-major] Breast Neoplasms / pathology. Neoplasms, Fibroepithelial / pathology. Stromal Cells / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Fibroadenoma / diagnosis. Fibroadenoma / pathology. Humans. Middle Aged. Mitosis. Phyllodes Tumor / diagnosis. Phyllodes Tumor / pathology

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19608080.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
  •  go-up   go-down


20. Hirose M, Hashizume T, Seino N, Kubota H, Nobusawa H, Gokan T: Atlas of breast magnetic resonance imaging. Curr Probl Diagn Radiol; 2007 Mar-Apr;36(2):51-65
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atlas of breast magnetic resonance imaging.
  • Magnetic resonance imaging (MRI) of the breast has become important not only for assessing the extent of breast cancer for breast-conserving surgery but also for the evaluation and diagnosis of other benign and malignant pathologies.
  • We radiologists therefore need to know the appropriate indications for performing breast MRI and understand the MRI features of breast disease.
  • We herein review and discuss the application of current pulse sequences and the imaging strategies for MRI of breast pathologies.
  • We will illustrate the MRI features of various breast pathologies including malignant tumors such as invasive and noninvasive ductal carcinoma, special types of invasive carcinoma (mucinous, apocrine, lobular carcinoma, spindle cell carcinoma, and so on), inflammatory carcinoma, semimalignant tumor (phyllodes tumor), benign tumors (fibroadenoma, intraductal and intracystic papilloma), inflammatory conditions, and postsurgical changes.
  • We will also demonstrate three-dimensional fusion images of MR ductography and breast MRI of patients with nipple discharge.
  • [MeSH-major] Breast Diseases / diagnosis. Magnetic Resonance Imaging
  • [MeSH-minor] Breast Neoplasms / diagnosis. Female. Humans

  • MedlinePlus Health Information. consumer health - Breast Diseases.
  • MedlinePlus Health Information. consumer health - MRI Scans.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17331837.001).
  • [ISSN] 0363-0188
  • [Journal-full-title] Current problems in diagnostic radiology
  • [ISO-abbreviation] Curr Probl Diagn Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 44
  •  go-up   go-down


21. Resetkova E, Khazai L, Albarracin CT, Arribas E: Clinical and radiologic data and core needle biopsy findings should dictate management of cellular fibroepithelial tumors of the breast. Breast J; 2010 Nov-Dec;16(6):573-80
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical and radiologic data and core needle biopsy findings should dictate management of cellular fibroepithelial tumors of the breast.
  • Fibroepithelial lesions with cellular stroma identified on core needle biopsy (CNB) may prove to be either fibroadenoma or phyllodes tumor at excision; therefore, management of these rare lesions is highly controversial.
  • Radiologic findings (mammogram and sonogram) and multiple histologic parameters on CNB specimen were blindly re-evaluated by one experienced breast radiologist and two breast pathologists, respectively, and results were correlated with final diagnosis at excision.
  • Cellular fibroepithelial lesions with indeterminate or suspect imaging findings, with larger size, and with an equivocal comment such as "cannot rule out phyllodes tumor" in the pathology report were excised more frequently (p = 0.05, p = 0.034, and p = 0.01, respectively).
  • Of 43 excised lesions, 13 were classified as benign phyllodes tumors, 23 as fibroadenoma and seven as benign cellular fibroepithelial lesion.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / pathology. Fibroadenoma / pathology. Mammography. Phyllodes Tumor / pathology

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • MedlinePlus Health Information. consumer health - Mammography.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] © 2010 Wiley Periodicals, Inc.
  • (PMID = 21070433.001).
  • [ISSN] 1524-4741
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  •  go-up   go-down


22. Lacroix-Triki M, Geyer FC, Lambros MB, Savage K, Ellis IO, Lee AH, Reis-Filho JS: β-catenin/Wnt signalling pathway in fibromatosis, metaplastic carcinomas and phyllodes tumours of the breast. Mod Pathol; 2010 Nov;23(11):1438-48
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] β-catenin/Wnt signalling pathway in fibromatosis, metaplastic carcinomas and phyllodes tumours of the breast.
  • It has been suggested that various spindle cell lesions of the breast may harbour Wnt pathway activation.
  • Given that β-catenin nuclear localization constitutes a good surrogate marker of Wnt canonical pathway activation, we have investigated the distribution of β-catenin in spindle cell lesions of the breast and whether it could be employed in the differential diagnosis of these lesions.
  • A total of 52 metaplastic breast carcinomas, eight fibromatoses and 23 phyllodes tumours were retrieved from our institutions' archives.
  • In all, three fibromatoses and 21 metaplastic breast carcinomas were subjected to CTNNB1 (β-catenin encoding gene) mutation analysis by direct gene sequencing.
  • All fibromatoses and 23% of metaplastic breast carcinomas expressed nuclear β-catenin.
  • In fibromatosis, β-catenin was more often diffusely expressed, whereas in metaplastic breast carcinomas, expression was more frequently focal.
  • Membranous β-catenin expression was significantly lower in spindle cell carcinomas than in other subtypes of metaplastic breast carcinomas.
  • In phyllodes tumours, stromal cells of benign and malignant subtypes displayed nuclear β-catenin expression in 94 and 57% of cases, respectively.
  • In conclusion, β-catenin nuclear expression is a common feature in fibromatoses and in the stromal component of phyllodes tumours, but may also be observed in metaplastic breast carcinomas.
  • β-catenin nuclear expression should not be used as a single marker to differentiate fibromatosis from other spindle cell tumours of the breast.
  • [MeSH-major] Biomarkers, Tumor / analysis. Breast Neoplasms / chemistry. Carcinoma / chemistry. Fibroma / chemistry. Phyllodes Tumor / chemistry. Signal Transduction. Wnt Proteins / analysis. beta Catenin / analysis

  • Genetic Alliance. consumer health - Fibromatosis.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20693983.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CTNNB1 protein, human; 0 / Wnt Proteins; 0 / beta Catenin
  •  go-up   go-down


23. Lenhard MS, Kahlert S, Himsl I, Ditsch N, Untch M, Bauerfeind I: Phyllodes tumour of the breast: clinical follow-up of 33 cases of this rare disease. Eur J Obstet Gynecol Reprod Biol; 2008 Jun;138(2):217-21
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phyllodes tumour of the breast: clinical follow-up of 33 cases of this rare disease.
  • OBJECTIVE: The "cystosarcoma phyllodes" of the breast is a rare entity which accounts for 0.5% of all breast neoplasms.
  • STUDY DESIGN: The data of 5270 patients with primary breast neoplasms treated in our department between 1984 and 2005 were retrospectively analysed for the histopathologic diagnosis of a cystosarcoma phyllodes.
  • RESULTS: Retrospective analysis of 5270 patients with primary breast neoplasms revealed 33 patients.
  • In the histopathological analysis, tumour grade was classified as benign in 40%, borderline in 27% and malignant in 33% of patients.
  • Breast conserving surgery was conducted in 58% of the patients, mastectomy in 42%.
  • The local recurrence rate was 50% in malignant, 20% in borderline and only 8% in benign tumours.
  • Distant metastases were seen in three patients (9%) with malignant phyllodes tumours.
  • [MeSH-major] Breast Neoplasms / pathology. Phyllodes Tumor / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Middle Aged. Neoplasm Recurrence, Local. Rare Diseases. Retrospective Studies

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17868973.001).
  • [ISSN] 0301-2115
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  •  go-up   go-down


24. Kuijper A, Snijders AM, Berns EM, Kuenen-Boumeester V, van der Wall E, Albertson DG, van Diest PJ: Genomic profiling by array comparative genomic hybridization reveals novel DNA copy number changes in breast phyllodes tumours. Cell Oncol; 2009;31(1):31-9
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genomic profiling by array comparative genomic hybridization reveals novel DNA copy number changes in breast phyllodes tumours.
  • Breast phyllodes tumour (PT) is a rare fibroepithelial tumour.
  • 11 PTs and 3 fibroadenomas, a frequently occurring fibroepithelial breast tumour, were analyzed.
  • Recurrent copy number gain was seen on 1q, 2p, 3q, 7p, 8q, 16q, 20.In this study we used array CGH for genomic profiling of fibroepithelial breast tumours.
  • Since copy number change was found in all benign PT, genomic instability may be an early event in PT genesis.

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • COS Scholar Universe. author profiles.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19096148.001).
  • [ISSN] 1875-8606
  • [Journal-full-title] Cellular oncology : the official journal of the International Society for Cellular Oncology
  • [ISO-abbreviation] Cell. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA 101359; United States / NCI NIH HHS / CA / CA 90421
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC4618888
  •  go-up   go-down


25. Yamaguchi R, Tanaka M, Kishimoto Y, Ohkuma K, Ishida M, Kojiro M: Ductal carcinoma in situ arising in a benign phyllodes tumor: report of a case. Surg Today; 2008;38(1):42-5
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ductal carcinoma in situ arising in a benign phyllodes tumor: report of a case.
  • Malignant epithelial change within a phyllodes tumor (PT) is a rare event.
  • The epithelial element consisted of irregularly dilated ducts with a phyllodes structure that had moderate to severe epithelial hyperplasia, and foci of cribriform ductal carcinoma in situ with comedo necrosis.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma in Situ / pathology. Carcinoma, Ductal, Breast / pathology. Neoplasms, Multiple Primary / pathology. Phyllodes Tumor / pathology

  • Genetic Alliance. consumer health - Phyllodes Tumor.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Arch Pathol Lab Med. 1987 Sep;111(9):873-5 [2820345.001]
  • [Cites] Cancer. 1975 Aug;36(2):599-605 [168959.001]
  • [Cites] J Surg Oncol. 1990 Sep;45(1):46-51 [2166186.001]
  • [Cites] Tumori. 1986 Apr 30;72(2):187-90 [3010519.001]
  • [Cites] J Pathol. 2002 Apr;196(4):437-44 [11920740.001]
  • [Cites] Virchows Arch. 1998 Jan;432(1):89-93 [9463593.001]
  • [Cites] Histopathology. 1995 Sep;27(3):205-18 [8522284.001]
  • [Cites] Histopathology. 1997 Jan;30(1):98-9 [9023568.001]
  • [Cites] Pathology. 2005 Oct;37(5):393-6 [16194856.001]
  • [Cites] Cancer. 1996 Jun 1;77(11):2267-74 [8635094.001]
  • [Cites] Am J Clin Pathol. 2005 Apr;123(4):529-40 [15743740.001]
  • (PMID = 18085361.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


26. Tomita T, Ren Y, Davis M, Tawfik O: Phyllodes tumor of borderline malignancy: seven year follow up with immunohistochemical study. Pathol Int; 2005 Sep;55(9):585-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phyllodes tumor of borderline malignancy: seven year follow up with immunohistochemical study.
  • The patient was 80 years old when she initially presented with a left breast mass.
  • Originally, a needle biopsy showed benign stromal and ductal cells.
  • Five years later, the breast mass increased in size and a core needle biopsy showed a biphasic intraductal papillomatous tumor with cellular stroma.
  • Eighteen months later, another biopsy was taken from the breast mass, revealing a well-developed phyllodes tumor (PT) of borderline malignancy.
  • Histolopathologic and immunohistochemical studies, including estrogen and progesterone receptors, Ki-67 and p53, performed on tissues from the different biopsy specimens confirmed the progressive transition of the tumor in a 7 year period.
  • [MeSH-major] Breast Neoplasms / pathology. Phyllodes Tumor / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor. Biopsy, Needle. Female. Follow-Up Studies. Humans. Mastectomy, Simple. Mitosis. Time Factors. Treatment Outcome

  • Genetic Alliance. consumer health - Phyllodes Tumor.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16143035.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


27. Norat F, Dreant N, Riah Y, Lebreton E: [Extraordinary case of malignant phylloid tumor of the breast: surgical reconstruction treatment]. Ann Ital Chir; 2009 Nov-Dec;80(6):475-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Extraordinary case of malignant phylloid tumor of the breast: surgical reconstruction treatment].
  • Phyllode tumors of the breast are fibroepithelial tumors similar to fibroadenomas but with a predominant conjunctive tissue component.
  • They are rare with an incidence of less than 1% of all breast neoplasms.
  • They can be divided in three categories: benign, borderline, malignant.
  • The Authors report the case of a 53 years old woman who presented an exceptional 6.5 kg phylloid tumor of the left mamma.
  • [MeSH-major] Breast Neoplasms / surgery. Mammaplasty. Phyllodes Tumor / surgery

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • MedlinePlus Health Information. consumer health - Breast Reconstruction.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20476683.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
  •  go-up   go-down


28. Kersting C, Kuijper A, Schmidt H, Packeisen J, Liedtke C, Tidow N, Gustmann C, Hinrichs B, Wülfing P, Tio J, Boecker W, van Diest P, Brandt B, Buerger H: Amplifications of the epidermal growth factor receptor gene (egfr) are common in phyllodes tumors of the breast and are associated with tumor progression. Lab Invest; 2006 Jan;86(1):54-61
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Amplifications of the epidermal growth factor receptor gene (egfr) are common in phyllodes tumors of the breast and are associated with tumor progression.
  • Phyllodes tumors of the breast are rare biphasic tumors with the potential for invasion and metastatic spread.
  • An important role of the epidermal growth factor receptor (EGFR) in phyllodes tumors has been proposed.
  • We investigated 58 phyllodes tumors of the breast (40 benign, 10 borderline and eight malignant) by means of egfr fluorescence in situ hybridization (FISH) and gene dosage PCR for a regulatory sequence within intron 1 of egfr.
  • Immunopositivity for EGFR was detected in 19% of phyllodes tumors (75% of all malignant tumors) in stromal tumor cells but not in the epithelial component.
  • Whole-gene amplifications were seen by FISH in 15.8% (in stromal cells only) and intron 1 amplifications by gene dosage PCR in as much as 41.8% of all phyllodes tumors.
  • Significant correlations were seen between tumor grade on the one hand and EGFR overexpression (P=0.001) and intron 1 amplifications (P<0.05) on the other.
  • In conclusion, our results show for the first time that activating mutations in and overexpression of egfr are associated with the progression in grade of phyllodes tumors of the breast.
  • [MeSH-major] Breast Neoplasms / genetics. Gene Amplification. Phyllodes Tumor / genetics. Receptor, Epidermal Growth Factor / genetics


29. Chung EM, Cube R, Hall GJ, González C, Stocker JT, Glassman LM: From the archives of the AFIP: breast masses in children and adolescents: radiologic-pathologic correlation. Radiographics; 2009 May-Jun;29(3):907-31
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] From the archives of the AFIP: breast masses in children and adolescents: radiologic-pathologic correlation.
  • The spectrum of breast lesions in children and adolescents varies markedly from that for adults, with the former lesions being overwhelmingly benign.
  • A breast mass in a young boy or girl may arise from normal and abnormal breast development.
  • After onset of puberty, most cases of breast enlargement arise from benign fibroadenoma in girls and gynecomastia in boys.
  • These conditions have specific imaging appearances, although juvenile (often giant) fibroadenoma cannot be distinguished from phyllodes tumor, which can be benign or malignant.
  • A diagnosis of juvenile papillomatosis (a benign lesion) portends later development of breast cancer, and patients with this condition should be closely monitored.
  • Malignant lesions of the breast in children are rare.
  • The most common primary breast malignancy is malignant phyllodes tumor.
  • Primary breast carcinoma is exceedingly rare in the pediatric age group, but its imaging appearance in children is the same as seen in adults and is different from that of almost all benign lesions.
  • In girls, diagnostic interventions may injure the developing breast and cause subsequent disfigurement.
  • Given this risk and the low prevalence of malignant disease in this population, a prudent course should be followed in the diagnosis of breast lesions.
  • [MeSH-major] Breast Diseases / radiography
  • [MeSH-minor] Adolescent. Breast / abnormalities. Breast / anatomy & histology. Breast / growth & development. Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Breast Neoplasms / radiography. Breast Neoplasms, Male / diagnosis. Breast Neoplasms, Male / pathology. Breast Neoplasms, Male / radiography. Breast Neoplasms, Male / secondary. Carcinoma, Ductal, Breast / diagnosis. Carcinoma, Ductal, Breast / pathology. Carcinoma, Ductal, Breast / radiography. Carcinoma, Ductal, Breast / ultrasonography. Child. Child, Preschool. Female. Fibroadenoma / diagnosis. Fibroadenoma / pathology. Fibroadenoma / radiography. Granular Cell Tumor / diagnosis. Granular Cell Tumor / pathology. Granular Cell Tumor / radiography. Gynecomastia / pathology. Gynecomastia / radiography. Humans. Infant. Infant, Newborn. Male. Nipples / abnormalities. Papilloma / diagnosis. Papilloma / pathology. Papilloma / radiography. Phyllodes Tumor / diagnosis. Phyllodes Tumor / pathology. Phyllodes Tumor / radiography. Puberty. Puberty, Precocious / diagnosis. Young Adult

  • MedlinePlus Health Information. consumer health - Breast Diseases.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19448124.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 90
  •  go-up   go-down


30. Karim RZ, Gerega SK, Yang YH, Spillane A, Carmalt H, Scolyer RA, Lee CS: p16 and pRb immunohistochemical expression increases with increasing tumour grade in mammary phyllodes tumours. Histopathology; 2010 Jun;56(7):868-75
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] p16 and pRb immunohistochemical expression increases with increasing tumour grade in mammary phyllodes tumours.
  • AIMS: Control of cell cycling and proliferation is critical to the development of neoplasia and may play a role in the pathogenesis of phyllodes tumours (PTs).
  • METHODS AND RESULTS: Sixty-five PTs (34 benign, 23 borderline and eight malignant) diagnosed at a single institution between 1990 and 2006 were analysed.
  • [MeSH-major] Breast Neoplasms / metabolism. Neoplasm Proteins / metabolism. Phyllodes Tumor / metabolism. Retinoblastoma Protein / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Blotting, Western. Cyclin D1 / metabolism. Disease-Free Survival. Female. Humans. Immunohistochemistry. Ki-67 Antigen / metabolism. Tissue Array Analysis


31. Tse GM, Niu Y, Shi HJ: Phyllodes tumor of the breast: an update. Breast Cancer; 2010;17(1):29-34
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phyllodes tumor of the breast: an update.
  • Phyllodes tumor is an uncommon biphasic breast tumor, with the ability to recur and metastasize, and it behaves biologically like a stromal neoplasm.
  • Traditionally, phyllodes tumors are graded by the use of a set of histologic data into benign, borderline, and malignant.
  • In most series, all phyllodes tumors may recur, but only the borderline and malignant phyllodes tumors metastasize.
  • The expression of many biological markers, including p53, hormone receptors, proliferation markers, angiogenesis group of markers, c-kit, CD10 and epidermal growth factor receptor have been explored, and many have been shown to be variably expressed, depending on the grade of the tumor.
  • These markers are, however, of limited value in predicting the behavior of the tumor.
  • Recently investigators have reported a plethora of genetic changes in phyllodes tumors, the most consistent of which seems to be 1q gain by comparative genomic hybridization.
  • It is foreseeable that more exciting data will be generated to help us to understand the etiology and pathogenesis of phyllodes tumor.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Breast Neoplasms / pathology. Phyllodes Tumor / pathology
  • [MeSH-minor] Female. Humans. Neoplasm Staging. Prognosis


32. Uner A, Ozturk B, Benekli M, Coskun U, Kocak S, Kaya AO, Unsal D, Erekul S, Yaman E, Yildiz R, Buyukberber S: Synchronize primary breast osteosarcoma and contralateral benign cystosarcoma phylloides: radiologic and pathologic imaging. Breast J; 2008 Jan-Feb;14(1):109-10
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronize primary breast osteosarcoma and contralateral benign cystosarcoma phylloides: radiologic and pathologic imaging.
  • [MeSH-major] Breast Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Osteosarcoma / pathology. Phyllodes Tumor / pathology


33. Telli ML, Horst KC, Guardino AE, Dirbas FM, Carlson RW: Phyllodes tumors of the breast: natural history, diagnosis, and treatment. J Natl Compr Canc Netw; 2007 Mar;5(3):324-30
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phyllodes tumors of the breast: natural history, diagnosis, and treatment.
  • Phyllodes tumors of the breast are unusual fibroepithelial tumors that exhibit a wide range of clinical behavior.
  • These tumors are categorized as benign, borderline, or malignant based on a combination of histologic features.
  • The prognosis of phyllodes tumors is favorable, with local recurrence occurring in approximately 15% of patients overall and distant recurrence in approximately 5% to 10% overall.
  • [MeSH-major] Breast Neoplasms. Phyllodes Tumor

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17439760.001).
  • [ISSN] 1540-1405
  • [Journal-full-title] Journal of the National Comprehensive Cancer Network : JNCCN
  • [ISO-abbreviation] J Natl Compr Canc Netw
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 43
  •  go-up   go-down


34. Büchler T, Vorzilková E, Koukolík F, Melínova H, Abrahámová J: [Malignant subtype of cystosarcoma phyllodes with brain metastases]. Klin Onkol; 2010;23(6):446-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Malignant subtype of cystosarcoma phyllodes with brain metastases].
  • [Transliterated title] Maligní forma cystosarcoma phyllodes s metastázami do mozku.
  • Cystosarcoma phyllodes is an uncommon type of breast tumour.
  • Benign, borderline, and malignant subtypes have been described.
  • Central nervous system metastases of the malignant subtype of cystosarcoma phyllodes are rare and associated with poor prognosis.
  • We report on a patient with malignant cystosarcoma phyllodes who developed metastatic disease six years after resection of the primary breast tumour.
  • Because metastatic malignant cystosarcoma phyllodes are largely resistant to treatment, the most important objective is to provide optimal management of the primary tumour before dissemination occurs.
  • [MeSH-major] Brain Neoplasms / secondary. Breast Neoplasms / pathology. Phyllodes Tumor / secondary

  • Genetic Alliance. consumer health - Phyllodes Tumor.
  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21351423.001).
  • [ISSN] 0862-495X
  • [Journal-full-title] Klinická onkologie : casopis Ceské a Slovenské onkologické spolecnosti
  • [ISO-abbreviation] Klin Onkol
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
  •  go-up   go-down


35. Hossain D, Meiers I, Qian J, MacLennan GT, Bostwick DG: Prostatic stromal hyperplasia with atypia: follow-up study of 18 cases. Arch Pathol Lab Med; 2008 Nov;132(11):1729-33
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Prostatic stromal hyperplasia with atypia consists of 1 or more ill-defined, uncircumscribed, hyperplastic stromal nodules, with variable numbers of atypical, bizarre giant cells, with vacuolated nuclei, smudged chromatin, and frequent multinucleation infiltrating around benign acini.
  • CONCLUSIONS: Prostatic stromal hyperplasia with atypia is a rare, benign lesion, composed of degenerative myocytes with atypia that is histologically and clinically reminiscent of benign counterparts in the myometrium, breast, vulva, vagina, and elsewhere.
  • Recognition of this distinctive entity should allow separation from phyllodes tumor and sarcoma of the prostate.
  • The phrase stromal tumor of uncertain malignant potential is inappropriate for this benign tumor, and its use is discouraged.

  • MedlinePlus Health Information. consumer health - Enlarged Prostate (BPH).
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18976007.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Androgen; 0 / Vimentin
  •  go-up   go-down


36. Sabban F, Collinet P, Lucot JP, Boman F, Leroy JL, Vinatier D: [Phyllodes tumor of the breast: analysis of 8 patients]. J Gynecol Obstet Biol Reprod (Paris); 2005 May;34(3 Pt 1):252-6
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Phyllodes tumor of the breast: analysis of 8 patients].
  • [Transliterated title] Tumeurs phyllodes du sein: à propose de 8 patientes.
  • INTRODUCTION: Phyllodes tumors of breast are rare and usually benign.
  • MATERIALS AND METHODS: We reviewed 8 cases of phyllodes tumors and the literature to report the circumstances of occurrence of these tumors, and their specific clinical diagnosis, therapeutic, prognostic features.
  • Mean tumor size was 3.75 cm.
  • Aspiration cytology demonstrated the phyllode tumor in 43% of patients.
  • [MeSH-major] Breast Neoplasms / diagnosis. Phyllodes Tumor / diagnosis

  • Genetic Alliance. consumer health - Phyllodes Tumor.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16012385.001).
  • [ISSN] 0368-2315
  • [Journal-full-title] Journal de gynécologie, obstétrique et biologie de la reproduction
  • [ISO-abbreviation] J Gynecol Obstet Biol Reprod (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  •  go-up   go-down


37. Vargas HI, Vargas MP, Gonzalez K, Burla M, Khalkhali I: Percutaneous excisional biopsy of palpable breast masses under ultrasound visualization. Breast J; 2006 Sep-Oct;12(5 Suppl 2):S218-22
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Percutaneous excisional biopsy of palpable breast masses under ultrasound visualization.
  • A palpable breast mass is a common reason for surgical consultation.
  • Our goal was to determine whether ultrasound-guided vacuum-assisted core biopsy (US-VACB) is safe and effective in completely removing presumed benign palpable breast masses.
  • We conducted a cohort study of 201 consecutive patients with presumed benign palpable masses who underwent removal with US-VACB.
  • Palpable masses were successfully removed with US-VACB in 99% of cases; 2% were cancer and 7.5% were atypical ductal hyperplasia or phyllodes tumor.
  • US-VACB is safe and effective in the initial diagnosis and management of presumed benign palpable breast masses.
  • [MeSH-major] Breast Diseases / ultrasonography. Ultrasonography, Mammary / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy, Needle / methods. Breast Neoplasms / epidemiology. Breast Neoplasms / pathology. Breast Neoplasms / ultrasonography. California / epidemiology. Cohort Studies. Female. Humans. Middle Aged. Predictive Value of Tests. Prospective Studies. Ultrasonography, Interventional / methods. Vacuum

  • MedlinePlus Health Information. consumer health - Breast Diseases.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16959005.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


38. Iyengar P, Cody HS 3rd, Brogi E: Pleomorphic adenoma of the breast: case report and review of the literature. Diagn Cytopathol; 2005 Dec;33(6):416-20
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pleomorphic adenoma of the breast: case report and review of the literature.
  • Pleomorphic adenoma of the breast (PAB) is a very rare neoplasm.
  • On cytologic material, fibroadenoma and phyllodes tumor should also be considered within the differential diagnosis.
  • Correct identification of this benign mammary neoplasm is important to avoid unnecessarily aggressive treatment.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Breast Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2005 Wiley-Liss, Inc
  • (PMID = 16299746.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


39. Aranda C, Sotelo M, Torres A, Zárate M: [Phyllodes tumor and pregnancy. A report of a case]. Ginecol Obstet Mex; 2005 Jul;73(7):387-92
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Phyllodes tumor and pregnancy. A report of a case].
  • [Transliterated title] Tumor phyllodes y embarazo. Reporte de un caso.
  • Phyllodes tumor is a rare breast fibroepithelial neoplasm of the breast, predominant in females (0.3 to 0.5%).
  • Phyllodes tumor during pregnancy grows fast and its size is relatively big.
  • These tumors can be classified as benign, malignant or neighboring.
  • A 32-year-old patient at 23.4 week of gestation was admitted in the National Institute of Perinatology with a rapidly growing mass in the right breast; diagnosis confirmed by ultrasound study reporting echoic images on right breast, 10 x 10 cm the greatest and 3x3 cm the smallest.
  • A simple mastectomy was performed at the 26.6 week of gestation on the right breast.
  • A possible phyllodes tumour in the right breast was observed during surgery, weight 9.6 pounds, with partial infiltration to major pectoral muscle.
  • Pathology reported a benign phyllodes tumor in the right breast, with surgical borders free of tumor.
  • Phyllodes tumor is rare and can occur during pregnancy.
  • It is unknown if the tumor is hormone-dependent.
  • The growth of a tumor on a subsequent pregnancy is not necessarily associated with recurrency or with a new disorder on the patient, who has had a complete excision.
  • [MeSH-major] Breast Neoplasms. Phyllodes Tumor. Pregnancy Complications, Neoplastic


40. Taira N, Aogi K, Ohsumi S, Takashima S, Kawamura S, Nishimura R: Epidermal inclusion cyst of the breast. Breast Cancer; 2007;14(4):434-7
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidermal inclusion cyst of the breast.
  • Epidermal inclusion cysts are uncommon in the breast, but the consequences can be severe when these cysts occur in the breast parenchyma.
  • The patient in case 1 was an 85-year-old woman with a 3-cm palpable mass in the right breast.
  • Mammography revealed a round and smoothly outlined mass, which indicated a benign tumor, and sonography showed an irregularly shaped and heterogeneous hypoechoic mass.
  • Breast cancer was suspected on the basis of the sonographic findings and the age of the patient, but excisional biopsy revealed an epidermal inclusion cyst.
  • The patient in case 2 was a 45-year-old woman with a 9-cm lesion in the left breast.
  • A phyllodes tumor or a giant fibroadenoma was suspected on the basis of clinical and imaging findings, but the resected specimen revealed an epidermal inclusion cyst.
  • [MeSH-major] Breast Diseases / ultrasonography. Epidermal Cyst / ultrasonography. Ultrasonography, Mammary

  • MedlinePlus Health Information. consumer health - Breast Diseases.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17986812.001).
  • [ISSN] 1880-4233
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


41. Khurshid A, Kayani N, Bhurgri Y: Phylloides tumors in adolescent girls and young women in Pakistan. Asian Pac J Cancer Prev; 2006 Oct-Dec;7(4):563-6
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The objective of this study was to determine the frequency of phylloides tumor (PT) in adolescent girls and young women (less than and equal to 25 years of age) and to define the clinico-pathological features of PT in this unusual clinical setting.
  • The number of benign (BPT), borderline (BLPT) and malignant (MPT) was identical i.e.
  • High grade PT (BLPT and MPT) is an uncommon mammary tumor in adolescent girls and young women but seems to be occurring with increased frequency in the study population.
  • [MeSH-major] Breast Neoplasms / epidemiology. Phyllodes Tumor / epidemiology

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17250427.001).
  • [ISSN] 1513-7368
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
  •  go-up   go-down


42. Kuijper A, de Vos RA, Lagendijk JH, van der Wall E, van Diest PJ: Progressive deregulation of the cell cycle with higher tumor grade in the stroma of breast phyllodes tumors. Am J Clin Pathol; 2005 May;123(5):690-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Progressive deregulation of the cell cycle with higher tumor grade in the stroma of breast phyllodes tumors.
  • We studied cell cycle-regulating proteins in phyllodes tumor pathogenesis by immunohistochemical analysis for Ki-67, cyclin A, cyclin D1, retinoblastoma protein (pRb), p53, p16INK4A, bcl-2, and p21waf1 in the epithelium and stroma of 40 primary (benign, 21; borderline, 8; malignant, 11) and 7 recurrent tumors of different grades.
  • Stromal overexpression of p16INK4A, p53, cyclin A, pRb, and p21waf1 correlated significantly with tumor grade.
  • Stromal cyclin A expression was the best separating marker between tumor grades.
  • The stromal component of mammary phyllodes tumors displays an increasing level of cell cycle deregulation with higher tumor grade; the epithelial compartment mostly remains inconspicuous.
  • Several combinations of aberrantly expressed cell cycle proteins seem important in the stromal progression of phyllodes tumors.
  • [MeSH-major] Breast Neoplasms / pathology. Cell Cycle. Cell Cycle Proteins / metabolism. Phyllodes Tumor / pathology. Stromal Cells / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Female. Humans. Immunoenzyme Techniques. Middle Aged. Neoplasm Proteins / metabolism. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Prognosis


43. Yamamoto H, Okumura K, Toshima S, Mukaisho K, Sugihara H, Hattori T, Kato M, Asano S: FXYD3 protein involved in tumor cell proliferation is overproduced in human breast cancer tissues. Biol Pharm Bull; 2009 Jul;32(7):1148-54
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] FXYD3 protein involved in tumor cell proliferation is overproduced in human breast cancer tissues.
  • FXYD3, also known as Mat-8 (Mammary tumor 8 kDa), is one of mRNAs highly expressed in mouse and human breast cancers.
  • Here, we newly found that FXYD3 protein was also overexpressed in human breast cancer specimens; invasive ductal carcinomas and intra-ductal carcinomas, whereas its expression was low in benign lesion specimens; mastopathy, fibroadenoma and phyllodes tumors.
  • Here, we found that FXYD3a mRNA is a major transcript product expressed in human normal tissues as well as in breast, colon, stomach and pancreas cancer cell lines.
  • Cell proliferation rate of MCF-7 breast cancer cell line was drastically decreased when FXYD3a and 3b mRNAs were suppressed by the small interfering RNA.
  • These results suggest that FXYD3a protein is highly expressed in breast cancers, and responsible for cancer cell proliferation.
  • [MeSH-major] Breast Neoplasms / metabolism. Cell Proliferation. Membrane Proteins / biosynthesis. Neoplasm Proteins / biosynthesis
  • [MeSH-minor] Adult. Aged. Amino Acid Sequence. Blotting, Western. Cell Line, Tumor. Female. Humans. Immunohistochemistry. Middle Aged. Molecular Sequence Data. Reverse Transcriptase Polymerase Chain Reaction. Sequence Alignment. Transfection

  • Genetic Alliance. consumer health - Breast Cancer.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19571376.001).
  • [ISSN] 0918-6158
  • [Journal-full-title] Biological & pharmaceutical bulletin
  • [ISO-abbreviation] Biol. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / FXYD3 protein, human; 0 / Membrane Proteins; 0 / Neoplasm Proteins
  •  go-up   go-down


44. Chung A, Scharre K, Wilson M: Intraductal fibroadenomatosis: an unusual variant of fibroadenoma. Breast J; 2008 Mar-Apr;14(2):193-5
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We present a case of a benign breast lesion that contains histopathologic characteristics of fibroadenoma, phyllodes tumor, intraductal adenoma and papilloma.
  • [MeSH-major] Breast Neoplasms / pathology. Fibroadenoma / pathology

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18248554.001).
  • [ISSN] 1524-4741
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


45. Ahmed HG, Ali AS, Almobarak AO: Frequency of breast cancer among Sudanese patients with breast palpable lumps. Indian J Cancer; 2010 Jan-Mar;47(1):23-6
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Frequency of breast cancer among Sudanese patients with breast palpable lumps.
  • BACKGROUND: Breast cancer mortality is high in Sudan and most patients are detected at later stages of the disease due to the lack of awareness and absence of screening programs.
  • This study aimed to determine the pattern and frequency of breast cancer among patients presenting with palpable breast lumps within one year duration.
  • METHODS AND MATERIALS: We obtained information (patient's personal data) and Fine-Needle Aspiration (FNA) materials, for occurrence of 200 breast lesions in patients.
  • RESULTS: The diagnoses of the 200 breast lesions were as follows: 68 (34%) were malignant, 56 cases (28%) were fibroadenoma, 23 cases (11.5%) were fibrocystic change, 22 cases (11%) were inflammatory lesions (including mastitis and abscess formation), 12 cases (6%) were benign cysts and the remaining 19 patients (9.5%) were with lactation changes (8 cases), lipoma (6 cases), gynecomastia (3 cases) and phyllodes tumor (2 cases).
  • CONCLUSIONS: The frequency of advanced breast cancer among patients with breast lesions is high, in this subset of patients, which signals the urgency for implementation of breast screening programs.
  • [MeSH-major] Breast Neoplasms / diagnosis. Breast Neoplasms / epidemiology. Breast Neoplasms, Male / diagnosis. Breast Neoplasms, Male / epidemiology
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Age Factors. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Breast Diseases / diagnosis. Breast Diseases / epidemiology. Female. Humans. Male. Middle Aged. Sudan / epidemiology. Young Adult


46. Ferbeyre-Binelfa L, Ramírez-Bollas J, Bautista-Piña V, Espejo-Fonseca R, Ruvalcaba-Limón E, Serratos-Garduño E: [Fibromatosis of the breast. Report of two cases and review of the literature]. Cir Cir; 2009 Jul-Aug;77(4):313-8; 291-6
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Fibromatosis of the breast. Report of two cases and review of the literature].
  • BACKGROUND: Fibromatosis is a term used to describe a group of lesions characterized by well-differentiated fibroblast proliferation with an usually benign biological behavior but with an infiltrative pattern of growth, frequently recurrent and locally invasive.
  • The presence of this entity in breast tissue is an uncommon clinical situation, comprising approximately 0.2% of breast tumors and very often misdiagnosed as malignant disease or phyllodes tumor.
  • In this rare condition, immunohistochemistry is an important diagnostic tool in anatomopathological differential diagnosis with other spindle cell tumors of the breast.
  • CLINICAL CASES: We present two cases of breast fibromatosis confirmed immunohistochemically and also by biopsy.
  • One case had the clinical and imaging appearance of breast carcinoma with the classic irregular mass presentation and the other case was misdiagnosed as phyllodes tumor because of the size and density of the tumor and the cytology.
  • CONCLUSIONS: Approximately 83 cases of breast fibromatosis have been reported during the last 30 years, including one male patient.
  • We reviewed clinicopathological features of two cases of fibromatosis of the breast treated at our institute.
  • [MeSH-major] Breast Neoplasms / diagnosis. Fibroma / diagnosis

  • Genetic Alliance. consumer health - Fibromatosis.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19919794.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Mexico
  • [Number-of-references] 44
  •  go-up   go-down


47. Fernández-Aguilar S, Noël JC: [Malignant phyllodes tumor of the breast with osteoclast-like giant cells: a case report]. Ann Pathol; 2007 Feb;27(1):31-4
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Malignant phyllodes tumor of the breast with osteoclast-like giant cells: a case report].
  • Breast tumors, particularly of stromal origin, containing multinucleated osteoclast-like giant cells (OLGC) are rarely reported in the literature.
  • We report here the first case of a malignant phyllodes tumor associated with OLGC occurring in a 43 year-old African woman who presented with a painful palpable mass of the outer upper quadrant of the right breast.
  • After surgical excision, histological examination showed a malignant phyllodes tumor in which the stromal component displayed evident sarcomatous changes and was densely populated with benign multinucleated OLGC.
  • This lesion ressembles giant cell tumor of bone.
  • [MeSH-major] Breast Neoplasms / pathology. Giant Cells / pathology. Osteoclasts / pathology. Phyllodes Tumor / pathology

  • Genetic Alliance. consumer health - Phyllodes Tumor.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17568357.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  •  go-up   go-down


48. Dubb M, Michelow P, Grayson W: Cytologic features of trichoblastoma in fine needle aspiration biopsies. Acta Cytol; 2009 Nov-Dec;53(6):679-82
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • On fine needle aspiration, the patient was diagnosed as having a benign skin adnexal tumor.
  • RESULTS: The cytologic features of trichoblastoma resembled a cellular fibroadenoma/phyllodes tumor on aspiration, not previously described in the literature.
  • If the tumor occurs in the region of the breast, distinction from a fibroadenoma would be difficult if these additional features were not prominent.
  • CONCLUSION: Knowledge of the cytologic features of trichoblastoma will allow correct management of the patient and prevent misdiagnosis as other benign or malignant tumors.

  • MedlinePlus Health Information. consumer health - Hair Problems.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20014558.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


49. Tan PH, Jayabaskar T, Chuah KL, Lee HY, Tan Y, Hilmy M, Hung H, Selvarajan S, Bay BH: Phyllodes tumors of the breast: the role of pathologic parameters. Am J Clin Pathol; 2005 Apr;123(4):529-40
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phyllodes tumors of the breast: the role of pathologic parameters.
  • We aimed to establish whether morphologic parameters were prognostically important in a large series of breast phyllodes tumors in Asian women.
  • Of 335 phyllodes tumors diagnosed at the Department of Pathology, Singapore General Hospital, Singapore, between January 1992 and December 2002, 250 (74.6%) were benign, 54 (16.1%) borderline, and 31 (9.3%) malignant, based on histologic review of archival slides.
  • The 7 women who died of disease during follow-up had malignant phyllodes tumor at the outset and experienced recurrences, and death was preceded by distant metastases.
  • [MeSH-major] Breast Neoplasms / pathology. Phyllodes Tumor / pathology
  • [MeSH-minor] Adolescent. Aged. Asia. Female. History, 16th Century. Humans. Middle Aged. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Prognosis

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15743740.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  •  go-up   go-down


50. Sapino A, Bosco M, Cassoni P, Castellano I, Arisio R, Cserni G, Dei Tos AP, Fortunati N, Catalano MG, Bussolati G: Estrogen receptor-beta is expressed in stromal cells of fibroadenoma and phyllodes tumors of the breast. Mod Pathol; 2006 Apr;19(4):599-606
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Estrogen receptor-beta is expressed in stromal cells of fibroadenoma and phyllodes tumors of the breast.
  • An estrogen dependency has been suggested for the growth of fibroadenomas: however, thus far, none of the steroid hormone receptors acting on breast tissues has been demonstrated in the stroma of breast fibroepithelial lesions.
  • In this study, the expression of estrogen receptor (ER)-alpha and -beta was investigated by immunohistochemistry in 33 fibroadenomas and in 30 benign, three borderline and seven malignant phyllodes tumors, all with spindle cell growth and in one distant metastasis.
  • ER-beta was the only hormone receptor expressed by stroma of fibroadenomas and phyllodes tumors, both at protein and mRNA level.
  • The highest percentage of ER-beta was observed in fibroadenomas with cellular stroma and in phyllodes tumors.
  • In contrast, in phyllodes tumors, ER-beta expression was higher in older patients.
  • In conclusion, (i) only ER-beta is detected in the stroma of fibroadenomas and phyllodes tumors;.
  • Conversely, the older age of patients with ER-beta-rich phyllodes tumors suggests that mechanisms, probably independent from estrogen stimulation, act on the growth of these tumors.
  • [MeSH-major] Breast Neoplasms / pathology. Estrogen Receptor beta / genetics. Fibroadenoma / pathology. Phyllodes Tumor / pathology. Stromal Cells / pathology
  • [MeSH-minor] Actins / analysis. Adolescent. Adult. Aged. Calcium-Binding Proteins / analysis. Cell Line, Tumor. Estrogen Receptor alpha / analysis. Estrogen Receptor alpha / genetics. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Microfilament Proteins / analysis. Middle Aged. Muscle, Smooth / chemistry. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16554735.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Calcium-Binding Proteins; 0 / Estrogen Receptor alpha; 0 / Estrogen Receptor beta; 0 / Microfilament Proteins; 0 / RNA, Messenger; 0 / calponin
  •  go-up   go-down


51. Buch A, Rout P, Makhija P: Adenomyoepithelioma with phyllodes tumor--a rare combination in a solitary breast lump. Indian J Pathol Microbiol; 2006 Apr;49(2):259-61
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenomyoepithelioma with phyllodes tumor--a rare combination in a solitary breast lump.
  • An unusual combination of two benign breast neoplasms adenomyoepithelioma and phyllodes tumor presenting as a solitary breast lump have been described.
  • This patient also presented with a recurrent breast neoplasm.
  • [MeSH-major] Adenomyoma / pathology. Breast Neoplasms / pathology. Myoepithelioma / pathology. Neoplasms, Multiple Primary / pathology. Phyllodes Tumor / pathology
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Recurrence, Local / pathology

  • Genetic Alliance. consumer health - Phyllodes Tumor.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [ErratumIn] Indian J Pathol Microbiol. 2006 Jul;49(3):476
  • (PMID = 16933731.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  •  go-up   go-down


52. Kraemer B, Hoffmann J, Roehm C, Gall C, Wallwiener D, Krainick-Strobel U: Cystosarcoma phyllodes of the breast: a rare diagnosis: case studies and review of literature. Arch Gynecol Obstet; 2007 Dec;276(6):649-53
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystosarcoma phyllodes of the breast: a rare diagnosis: case studies and review of literature.
  • Cystosarcoma phyllodes (CP), otherwise known as phyllodes tumour (PT) of the breast, is a very rare but locally aggressive fibroepithelial tumour in its malignant form, and accounts for 0.3-1% of all breast neoplasias.
  • Using 4 cases reports with different histological classifications as examples (benign-borderline-malignant), we describe the (differential) diagnosis and treatment options of this tumour entity and give an additional review of the available literature.
  • [MeSH-major] Breast Neoplasms / pathology. Breast Neoplasms / surgery. Phyllodes Tumor / pathology. Phyllodes Tumor / surgery

  • Genetic Alliance. consumer health - Phyllodes Tumor.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17549503.001).
  • [ISSN] 0932-0067
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 19
  •  go-up   go-down


53. Pătraşcu A, Popescu CF, Pleşea IE, Bădulescu A, Tănase F, Mateescu G: Clinical and cytopathological aspects in phyllodes tumors of the breast. Rom J Morphol Embryol; 2009;50(4):605-11
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical and cytopathological aspects in phyllodes tumors of the breast.
  • The frequency of mesenchymal breast tumors is very low, being represented mostly by tumors with biphasic proliferation (phyllodes tumors) and less by other types of non-epithelial tumors.
  • From clinical point of view, phyllodes tumors (PT) can mimic a breast carcinoma.
  • In current study, we assessed clinical aspects of 79 phyllodes tumors regarding patient's age and localization of the tumors.
  • The median age of the patients was 46.07-year-old, being progressively higher with grade of the tumors with significant values between benign and borderline tumors (p=0.04954) and between benign and malignant ones (p=0.02890).
  • The preoperative differentiation between a breast phyllodes tumor and a breast carcinoma is extremely important for avoiding of a useless radical surgery for the patient.
  • [MeSH-major] Breast Neoplasms / pathology. Phyllodes Tumor / pathology

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19942954.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  •  go-up   go-down


54. Sakurai K, Enomoto K, Amano S: [Long-term results of surgical therapy for phyllodes tumor of the breast]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2784-5
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Long-term results of surgical therapy for phyllodes tumor of the breast].
  • We report that the long-term results of surgical therapy for phyllodes tumor of the breast.
  • During ten years, we experienced twenty-eight patients of phyllodes tumors of the breast.
  • The patients with local recurrence were diagnosed the benign phyllodes tumor of the breast at the first operation.
  • If the pathological diagnosis was benign phyllodes tumor and surgical margin was negative at the first operation, it is necessary to follow up the patients, because there is a risk of local and distant metastasis.
  • [MeSH-major] Breast Neoplasms / surgery. Phyllodes Tumor / surgery
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Mastectomy / methods. Middle Aged. Neoplasm Recurrence, Local. Treatment Outcome

  • Genetic Alliance. consumer health - Phyllodes Tumor.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21224712.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


55. Esposito NN, Mohan D, Brufsky A, Lin Y, Kapali M, Dabbs DJ: Phyllodes tumor: a clinicopathologic and immunohistochemical study of 30 cases. Arch Pathol Lab Med; 2006 Oct;130(10):1516-21
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phyllodes tumor: a clinicopathologic and immunohistochemical study of 30 cases.
  • CONTEXT: Phyllodes tumors (PTs) of the breast are biphasic neoplasms composed of epithelium and a spindle-cell stroma.
  • Currently, PTs are classified as benign, borderline, or malignant based on histopathologic features.
  • DESIGN: Sixteen benign, 8 borderline, and 6 malignant PTs with follow-up were examined for reactivity across a panel of immunohistochemical stains, including c-Kit, endothelin 1, p16, p21, p53, and Ki-67.
  • Tumor variables were compared among tumor subgroups and between tumors that did and did not recur.
  • RESULTS: Of the 30 PTs, 4 recurred (1 benign, 2 borderline, 1 malignant).
  • One patient with a malignant tumor died of metastatic disease 34 months after initial diagnosis.
  • The overall positive rate of c-Kit immunoreactivity was 13% in benign, 63% in borderline, and 67% in malignant PTs.
  • Endothelin 1 epithelial cytoplasmic staining was seen in 100% of benign, 50% of borderline, and 17% of malignant PTs.
  • Additionally, p16, p21, p53, and Ki-67 were differentially expressed among benign, borderline, and malignant tumors.
  • CONCLUSIONS: Stromal c-Kit positivity and epithelial endothelin 1 negativity are more often associated with malignant PTs; however, only positive margin status is significantly associated with tumor behavior.
  • [MeSH-major] Breast Neoplasms / metabolism. Breast Neoplasms / pathology. Phyllodes Tumor / metabolism. Phyllodes Tumor / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Disease Progression. Endothelin-1 / metabolism. Epithelium / metabolism. Female. Humans. Immunohistochemistry / methods. Ki-67 Antigen / metabolism. Mastectomy. Mastectomy, Segmental. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Proto-Oncogene Proteins c-kit / metabolism. Staining and Labeling. Tumor Suppressor Protein p53 / metabolism

  • Genetic Alliance. consumer health - Phyllodes Tumor.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • COS Scholar Universe. author profiles.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17090194.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Endothelin-1; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  •  go-up   go-down


56. Karim RZ, Gerega SK, Yang YH, Horvath L, Spillane A, Carmalt H, Scolyer RA, Lee CS: Proteins from the Wnt pathway are involved in the pathogenesis and progression of mammary phyllodes tumours. J Clin Pathol; 2009 Nov;62(11):1016-20
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Proteins from the Wnt pathway are involved in the pathogenesis and progression of mammary phyllodes tumours.
  • A comprehensive analysis of the expression of Wnt signalling pathway proteins in mammary phyllodes tumours (PTs) has not been previously performed.
  • METHODS: 65 PTs (34 benign, 23 borderline and 8 malignant) diagnosed at a single institution between 1990 and 2006 were analysed.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Breast Neoplasms / metabolism. Phyllodes Tumor / metabolism. Wnt Proteins / metabolism
  • [MeSH-minor] Cadherins / metabolism. Cohort Studies. Disease Progression. Female. Humans. Neoplasm Proteins / metabolism. Proto-Oncogene Proteins / metabolism. Signal Transduction / physiology. Survival Analysis. Tissue Array Analysis / methods. beta Catenin / metabolism

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19861560.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins; 0 / Neoplasm Proteins; 0 / Proto-Oncogene Proteins; 0 / SFRP4 protein, human; 0 / Wnt Proteins; 0 / beta Catenin
  •  go-up   go-down


57. Orea-Estudillo D, Jaimes-López L, Bernal-Cano J: [Phyllodes tumor in a pediatric patient. Case report and literature review]. Cir Cir; 2008 Mar-Apr;76(2):165-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Phyllodes tumor in a pediatric patient. Case report and literature review].
  • [Transliterated title] Tumor phyllodes en un paciente pediátrico. Informe de un caso y revisión de la literatura.
  • BACKGROUND: Phyllodes tumors occur with a frequency of 0.3- 0.9% and are rare in young women.
  • We present a phyllodes tumor in an 11-year-old female and we reviewed the literature regarding this pathology.
  • CASE REPORT: We present the case of an 11-year-old female with a diagnosis of phyllodes tumor.
  • Histological report demonstrated benign phyllodes tumor.
  • CONCLUSIONS: Small phyllodes tumors can be excised with a 1-cm surgical border, whereas larger phyllodes tumors are treated with simple mastectomy.
  • [MeSH-major] Breast Neoplasms. Phyllodes Tumor

  • Genetic Alliance. consumer health - Phyllodes Tumor.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18492439.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Mexico
  • [Number-of-references] 36
  •  go-up   go-down


58. Jayaram G, Jayalakshmi P, Yip CH: Leiomyosarcoma of the breast: report of a case with fine needle aspiration cytologic, histologic and immunohistochemical features. Acta Cytol; 2005 Nov-Dec;49(6):656-60
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Leiomyosarcoma of the breast: report of a case with fine needle aspiration cytologic, histologic and immunohistochemical features.
  • BACKGROUND: Leiomyosarcoma of the breast is a rare neoplasm.
  • We present a case of primary leiomyosarcoma of the breast in a middle-aged female in whom fine needle aspiration cytologic features suggested sarcoma.
  • CASE: A 55-year-old female presented with a rapidly growing breast lump of 1 month's duration.
  • On examination, an ulcerating, 12 x 10 cm tumor was seen involving the lower medial and lateral quadrants of the right breast.
  • A single cluster of benign ductal cells was seen.
  • The tumor cells did not express immunocytologic reactivity to estrogen receptor protein.
  • A cytologic diagnosis of sarcoma was given with differential diagnoses of metaplastic carcinoma and malignant phyllodes tumor.
  • Leiomyosarcoma of the breast shows fine needle aspiration cytologic features of sarcoma, but specific tumor typing may not be possible, especially when the cytologic material is inadequate for ancillary staining required to distinguish leiomyosarcoma from metaplastic carcinoma and malignant phyllodes tumor.
  • [MeSH-major] Breast Neoplasms / diagnosis. Leiomyosarcoma / diagnosis
  • [MeSH-minor] Biopsy, Fine-Needle / methods. Carcinoma / diagnosis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged. Phyllodes Tumor / diagnosis. Sensitivity and Specificity

  • Genetic Alliance. consumer health - Leiomyosarcoma.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] Diagn Cytopathol. 2007 Apr;35(4):254-6 [17351941.001]
  • (PMID = 16450908.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


59. Roa JC, Tapia O, Carrasco P, Contreras E, Araya JC, Muñoz S, Roa I: Prognostic factors of phyllodes tumor of the breast. Pathol Int; 2006 Jun;56(6):309-14
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic factors of phyllodes tumor of the breast.
  • The phyllodes tumor is characterized by its tendency to recur locally and occasionally to metastasize.
  • The purpose of the present paper was to assess the prognostic value of clinical-morphological characteristics in patients with phyllodes tumor.
  • Forty-seven cases of phyllodes tumors was studied; the World Health Organization classification was used and follow up was obtained.
  • A total of 51%, 28% and 21% of the tumors were classified as benign, borderline and malignant, respectively.
  • The adherence (P = 0.01), size >10 cm (P = 0.001), high mitotic activity (P = 0.03), infiltrative tumor margin (P = 0.0002) and type of surgery in malignant tumors (P = 0.02) proved to be good predictors of relapse.
  • Tumoral grade and some clinical-morphological characteristics of patients with phyllodes tumors have a significant impact on the prediction of its biological behavior.
  • [MeSH-major] Breast Neoplasms / diagnosis. Phyllodes Tumor / diagnosis

  • Genetic Alliance. consumer health - Phyllodes Tumor.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16704494.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  •  go-up   go-down


60. Tse GM, Tsang AK, Putti TC, Scolyer RA, Lui PC, Law BK, Karim RZ, Lee CS: Stromal CD10 expression in mammary fibroadenomas and phyllodes tumours. J Clin Pathol; 2005 Feb;58(2):185-9
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stromal CD10 expression in mammary fibroadenomas and phyllodes tumours.
  • In the breast, myoepithelial cells express CD10, but there are few studies of the expression of CD10 in mammary fibroepithelial lesions.
  • METHODS: Stromal CD10 expression was studied in 181 mammary phyllodes tumours (102 benign, 51 borderline malignant, and 28 frankly malignant) and 33 fibroadenomas using immunohistochemistry, to evaluate whether differences in expression correlated with the degree of malignancy.
  • RESULTS: There was a progressive increase in the patients' age and tumour size, from fibroadenoma to phyllodes tumours with an increasing degree of malignancy (p < 0.001).
  • Stromal CD10 expression was positive in one of 33 fibroadenomas, six of 102 benign phyllodes tumours, 16 of 51 borderline malignant phyllodes tumours, and 14 of 28 frankly malignant phyllodes tumours.
  • Stromal CD10 expression had a high specificity (95%) for differentiating between benign lesions (fibroadenomas and benign phyllodes tumours) and malignant (borderline and frankly malignant) phyllodes tumours.
  • [MeSH-major] Breast Neoplasms / immunology. Fibroadenoma / immunology. Neprilysin / immunology. Phyllodes Tumor / immunology. Stromal Cells / immunology

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Cytopathology. 1997 Jun;8(3):177-87 [9202893.001]
  • [Cites] Mod Pathol. 2002 Apr;15(4):397-405 [11950913.001]
  • [Cites] J Gastroenterol. 1996 Feb;31(1):12-7 [8808423.001]
  • [Cites] J Pathol. 1999 Oct;189(2):169-75 [10547570.001]
  • [Cites] Am J Surg Pathol. 2000 Feb;24(2):203-10 [10680888.001]
  • [Cites] Am J Clin Pathol. 2000 Mar;113(3):374-82 [10705818.001]
  • [Cites] Virchows Arch. 2002 Jun;440(6):589-93 [12070597.001]
  • [Cites] Mod Pathol. 2002 Jul;15(7):734-40 [12118111.001]
  • [Cites] Hum Pathol. 2002 Aug;33(8):806-11 [12203213.001]
  • [Cites] Mod Pathol. 2002 Sep;15(9):923-30 [12218209.001]
  • [Cites] Mod Pathol. 2003 Oct;16(10):1007-13 [14559983.001]
  • [Cites] Gynecol Oncol. 2004 Jan;92(1):71-9 [14751141.001]
  • [Cites] Mod Pathol. 2004 Jun;17(6):646-52 [15073596.001]
  • [Cites] Mod Pathol. 2004 Jul;17(7):827-31 [15044924.001]
  • [Cites] Clin Immunol Immunopathol. 1975 May;4(1):67-84 [1092499.001]
  • [Cites] Eur J Immunol. 1982 Apr;12(4):354-7 [6954072.001]
  • [Cites] Radiology. 1983 Feb;146(2):481-6 [6294737.001]
  • [Cites] Blood. 1983 Apr;61(4):628-39 [6338969.001]
  • [Cites] Adv Cancer Res. 1984;42:67-147 [6395656.001]
  • [Cites] Blood. 1986 Feb;67(2):474-8 [3080041.001]
  • [Cites] Am J Med. 1986 Jun;80(6):1249-52 [2942034.001]
  • [Cites] J Immunol. 1987 Jul 1;139(1):313-8 [2953817.001]
  • [Cites] Mol Cell Probes. 1989 Mar;3(1):39-44 [2525226.001]
  • [Cites] Surg Gynecol Obstet. 1990 Mar;170(3):193-6 [2154867.001]
  • [Cites] J Surg Oncol. 1990 Sep;45(1):46-51 [2166186.001]
  • [Cites] Am J Pathol. 1990 Oct;137(4):895-905 [1699423.001]
  • [Cites] Pathol Res Pract. 1990 Aug;186(4):427-38 [2174150.001]
  • [Cites] Cancer. 1991 Nov 1;68(9):2017-22 [1655234.001]
  • [Cites] Hum Reprod. 1992 Oct;7(9):1326-8 [1362204.001]
  • [Cites] Am J Surg. 1993 Mar;165(3):376-9 [8383473.001]
  • [Cites] Lab Invest. 1994 Jan;70(1):107-13 [8302012.001]
  • [Cites] Cancer. 1996 Mar 1;77(5):910-6 [8608483.001]
  • [Cites] Anticancer Res. 2000 Sep- Oct;20(5B):3539-44 [11131659.001]
  • [Cites] Ultrastruct Pathol. 2000 Nov-Dec;24(6):371-81 [11206334.001]
  • [Cites] Breast Cancer Res Treat. 2001 Jan;65(1):77-85 [11245343.001]
  • [Cites] Mod Pathol. 2001 May;14(5):465-71 [11353058.001]
  • [Cites] Histopathology. 2001 Jun;38(6):567-70 [11422501.001]
  • [Cites] Histopathology. 2001 Sep;39(3):273-8 [11532038.001]
  • [Cites] Am J Pathol. 2001 Oct;159(4):1415-21 [11583969.001]
  • [Cites] Int J Gynecol Pathol. 2002 Jan;21(1):41-7 [11781522.001]
  • [Cites] Am J Surg Pathol. 2002 Apr;26(4):403-12 [11914617.001]
  • [Cites] Histopathology. 1999 Jun;34(6):491-6 [10383692.001]
  • (PMID = 15677540.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 3.4.24.11 / Neprilysin
  • [Other-IDs] NLM/ PMC1770579
  •  go-up   go-down


61. Biondi A, Di Giuntao M, Motta S, Privitera G, Fichera DS, Ciuni R, Basile F: [Benign phylloides tumor of the breast. Considerations on a clinical case]. Ann Ital Chir; 2009 Nov-Dec;80(6):471-4
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Benign phylloides tumor of the breast. Considerations on a clinical case].
  • Phyllodes tumors are unusual biphasic fibroepithelial neoplasms of the breast, accounting for < 1% of all breast tumors and raising issues of diagnosis and therapeutic choice.
  • We talk about giant phyllodes tumors.
  • Conservative treatment can be effective also in giant tumors depending upon the size of the tumor and the breast if a complete excision with an adequate margin of normal breast tissue can be achieved, so avoiding local recurrence often accompanied by worse histopathology.
  • The Authors report the case of a giant benign phyllode tumor of the breast treated with conservative surgery, quadrantectomy and oncoplasty.
  • [MeSH-major] Breast Neoplasms. Phyllodes Tumor

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20476682.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
  •  go-up   go-down


62. Abdelkrim SB, Trabelsi A, Bouzrara M, Boudagga MZ, Memmi A, Bakir DA, Mokni M: Phyllodes Tumors of the Breast: A Review of 26 Cases. World J Oncol; 2010 Jun;1(3):129-134
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phyllodes Tumors of the Breast: A Review of 26 Cases.
  • Background: Phyllodes tumors of the breast are rare and locally aggressive neoplasms.
  • Methods: The authors analyzed retrospectively clinical, radiological, histopathological and therapeutic features as well as outcome in a series of 26 cases diagnosed as phyllodes tumors of the breast at the Pathology Department of Farhat Hached Hospital, Sousse, Tunisia, from 2003 to 2009.
  • The slides were reviewed in order to classify the tumors into benign, borderline and malignant on the basis of the criteria proposed by the World Health Organization.
  • The analysis of this series showed the following characteristics: mean age at diagnosis was 40 years (19 - 66), tumor size was 1.5 - 40 cm (mean: 7.8 cm); the chief complaint was a mammary mass; the right breast was affected in 14 cases, the upper outer quadrant was the most commonly involved site (42.3%); surgical treatment was used in all cases, 21 patients (80.8%) were treated conservatively (13 benign, 6 borderline, and 2 malignant) and 5 (19.2%) by radical surgery (1 borderline and 4 malignant); seven patients underwent post-operative radiotherapy; in 14/19 cases (73.7%), a good correlation was observed between intraoperative frozen section analysis and definitive histology; the tumor was classed as benign in 13 cases (50%), borderline in 7 cases (27%) and malignant in 6 cases (23%); follow-up data was available in 22 cases; the rate of recurrence was 23% (1 benign, 3 borderline, and 2 malignant) after a mean follow-up of 13.6 months; all the recurrent tumors were initially treated by lumpectomy and were close to margin at the initial pathologic examination; the treatment of recurrences consisted of simple mastectomy in 5 cases, and local excision in one case; three patients developed metastases, one of whom after recurrence<b>;</b> three patients have died.
  • Conclusions: This is a substantial single institution experience of a rare tumor.
  • Phyllodes tumors of the breast have an unpredictable outcome, thus a wide local excision, with an adequate margin of normal breast tissue, is the preferred initial therapy.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Breast Cancer Res Treat. 1999 Oct;57(3):291-5 [10617306.001]
  • [Cites] AJR Am J Roentgenol. 2003 Feb;180(2):332 [12540427.001]
  • [Cites] Surg Gynecol Obstet. 1975 Jun;140(6):929-32 [165582.001]
  • [Cites] Radiology. 1996 Jan;198(1):121-4 [8539362.001]
  • [Cites] Ann Surg Oncol. 2007 Oct;14(10):2961-70 [17562113.001]
  • [Cites] Jpn J Clin Oncol. 2007 Oct;37(10):730-6 [17932112.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2008 Feb 1;70(2):492-500 [17931796.001]
  • [Cites] Postgrad Med J. 2001 Jul;77(909):428-35 [11423590.001]
  • [Cites] Singapore Med J. 2008 Nov;49(11):e318-21 [19037540.001]
  • [Cites] Am J Surg. 2006 Aug;192(2):141-7 [16860620.001]
  • [Cites] Curr Treat Options Oncol. 2001 Apr;2(2):139-47 [12057132.001]
  • [Cites] Am J Surg. 2006 Oct;192(4):492-5 [16978957.001]
  • [Cites] Cancer. 2000 Oct 1;89(7):1502-11 [11013364.001]
  • [Cites] Breast. 2009 Jun;18(3):165-70 [19329316.001]
  • [Cites] Ann Surg. 1931 Jan;93(1):250-68 [17866470.001]
  • [Cites] Eur J Cancer. 1993;29A(9):1252-6 [8393684.001]
  • [Cites] Arch Gynecol Obstet. 2007 Dec;276(6):649-53 [17549503.001]
  • [Cites] Cancer. 1992 Jan 1;69(1):141-7 [1309302.001]
  • [Cites] Mod Pathol. 2001 Mar;14(3):185-90 [11266524.001]
  • [Cites] Histopathology. 1995 Sep;27(3):205-18 [8522284.001]
  • [Cites] J Natl Compr Canc Netw. 2007 Mar;5(3):324-30 [17439760.001]
  • [Cites] AJR Am J Roentgenol. 1996 Jul;167(1):187-9 [8659370.001]
  • [Cites] Cancer. 1996 Mar 1;77(5):910-6 [8608483.001]
  • [Cites] Am J Clin Pathol. 2005 Apr;123(4):529-40 [15743740.001]
  • [Cites] Arch Pathol Lab Med. 2006 Oct;130(10):1516-21 [17090194.001]
  • [Cites] Breast. 2007 Feb;16(1):27-37 [16876413.001]
  • (PMID = 29147192.001).
  • [ISSN] 1920-454X
  • [Journal-full-title] World journal of oncology
  • [ISO-abbreviation] World J Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Keywords] NOTNLM ; Outcome / Pathology / Phyllodes tumor / Prognosis / Treatment
  •  go-up   go-down


63. Verma S, Singh RK, Rai A, Pandey CP, Singh M, Mohan N: Extent of surgery in the management of phyllodes tumor of the breast: a retrospective multicenter study from India. J Cancer Res Ther; 2010 Oct-Dec;6(4):511-5
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extent of surgery in the management of phyllodes tumor of the breast: a retrospective multicenter study from India.
  • INTRODUCTION: Phyllodes tumor (PT) is a rare tumor of the breast.
  • OBJECTIVES: The objective of this retrospective study is to study the clinicopathological correlation of phyllodes tumors in North-Central part of the India and also to evaluate efficacy of the various surgical options available for the management of phyllodes tumors of the breast.
  • RESULTS: The breast masses in our study were particularly large.
  • Histopathological report was benign, borderline, and malignant PT in 62.4%, 20.8%, and 16.8% of the cases, respectively.
  • This study shows that wide local excision for benign and borderline and simple mastectomy with or without reconstruction for the malignant PT of the breast are acceptable best surgical options.
  • [MeSH-major] Breast Neoplasms / surgery. Phyllodes Tumor / surgery

  • Genetic Alliance. consumer health - Phyllodes Tumor.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21358091.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] India
  •  go-up   go-down


64. Istvanic S, Fischer AH, Banner BF, Eaton DM, Larkin AC, Khan A: Cell blocks of breast FNAs frequently allow diagnosis of invasion or histological classification of proliferative changes. Diagn Cytopathol; 2007 May;35(5):263-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cell blocks of breast FNAs frequently allow diagnosis of invasion or histological classification of proliferative changes.
  • Two major limitations of breast fine needle aspiration (FNA) compared with core needle biopsies (CNB) are the inability to determine whether a cancer is invasive and to classify proliferative lesions.
  • We studied 40 consecutive "rapid cell blocks" from breast FNAs with surgical pathology follow-up to test whether cell blocks can overcome these limitations.
  • One cystosarcoma phyllodes was suspected based on the cell block sections.
  • Cell blocks from 12 of 14 benign breast FNAs showed sufficient cells to assign a histologic diagnosis of no hyperplasia (1 case, confirmed on follow-up) and usual hyperplasia (11 cases; confirmed in eight of 11 on follow-up).
  • Cell blocks complement smears and monolayers and appear to overcome major limitations of breast FNA.
  • [MeSH-major] Biopsy, Fine-Needle. Breast / pathology. Breast Neoplasms / pathology. Neoplasms, Ductal, Lobular, and Medullary / pathology. Paraffin Embedding / methods
  • [MeSH-minor] Adenocarcinoma / classification. Adenocarcinoma / pathology. Carcinoma in Situ / classification. Carcinoma in Situ / pathology. Carcinoma, Lobular / classification. Carcinoma, Lobular / pathology. Cell Proliferation. Female. Humans. Hyperplasia. Neoplasm Invasiveness. Papilloma, Intraductal / classification. Papilloma, Intraductal / pathology. Phyllodes Tumor / classification. Phyllodes Tumor / pathology

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17427225.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


65. Bhargav PR, Mishra A, Agarwal G, Agarwal A, Verma AK, Mishra SK: Phyllodes tumour of the breast: clinicopathological analysis of recurrent vs. non-recurrent cases. Asian J Surg; 2009 Oct;32(4):224-8
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phyllodes tumour of the breast: clinicopathological analysis of recurrent vs. non-recurrent cases.
  • BACKGROUND: The aim of this study was to present our experience of dealing with patients with phyllodes tumours (PT) and to correlate the risk of local recurrence with different clinicopathological factors.
  • The histology report was benign, borderline and malignant PT in 28%, 20% and 52% of cases respectively.

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19892625.001).
  • [ISSN] 0219-3108
  • [Journal-full-title] Asian journal of surgery
  • [ISO-abbreviation] Asian J Surg
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] China
  •  go-up   go-down


66. Agabiti S, Gurrera A, Amico P, Vasquez E, Magro G: [Mammary hamartoma with atypical stromal cells: a potential diagnostic dilemma]. Pathologica; 2007 Dec;99(6):434-7
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Hamartoma of the breast is a pseudotumoural lesion that does not usually pose diagnostic problems for the pathologist.
  • Although atypical stromal cell (ASCs) can be encountered in several benign and malignant breast lesions, their occurrence in hamartoma has not been reported to date.
  • The authors report a case of breast hamartoma containing numerous atypical mono- or multinucleated stromal cells within the fibro-fatty component.
  • [MeSH-major] Breast Diseases / diagnosis. Hamartoma / diagnosis
  • [MeSH-minor] Antigens, CD34 / analysis. Biomarkers. Breast Neoplasms / diagnosis. Diagnosis, Differential. Female. Fibroblasts / chemistry. Fibroblasts / pathology. Humans. Lipoma / diagnosis. Liposarcoma / diagnosis. Middle Aged. Phyllodes Tumor / diagnosis. Stromal Cells / chemistry. Stromal Cells / pathology. Vimentin / analysis

  • MedlinePlus Health Information. consumer health - Breast Diseases.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18416336.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers; 0 / Vimentin
  •  go-up   go-down


67. Tan PH, Jayabaskar T, Yip G, Tan Y, Hilmy M, Selvarajan S, Bay BH: p53 and c-kit (CD117) protein expression as prognostic indicators in breast phyllodes tumors: a tissue microarray study. Mod Pathol; 2005 Dec;18(12):1527-34
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] p53 and c-kit (CD117) protein expression as prognostic indicators in breast phyllodes tumors: a tissue microarray study.
  • Breast phyllodes tumors are fibroepithelial neoplasms whose clinical behavior is difficult to predict on histology.
  • In this study, we determined if p53 and CD117 (c-kit) protein expression was predictive of behavior in a series of 335 phyllodes tumors diagnosed at the Singapore General Hospital, using immunohistochemistry on tissue microarrays.
  • Representative areas from 250 (75%) benign, 54 (16%) borderline and 31 (9%) malignant phyllodes tumors were selected for construction of tissue microarrays using the 2 mm punch.
  • Stromal p53 and CD117 protein expression was associated with tumor grade (P < 0.05).
  • We conclude that tissue microarrays are a convenient method for evaluating immunostaining results of large numbers of phyllodes tumors.
  • Although positive p53 stromal immunohistochemical detection may corroborate histologic malignancy, it is CD117 protein expression in phyllodes tumor stromal cells that may be of potential utility in predicting recurrent disease.
  • [MeSH-major] Breast Neoplasms / diagnosis. Phyllodes Tumor / diagnosis. Proto-Oncogene Proteins c-kit / metabolism. Tissue Array Analysis / methods. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Female. Humans. Immunohistochemistry. Middle Aged. Neoplasm Recurrence, Local. Prognosis

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • COS Scholar Universe. author profiles.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16258510.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  •  go-up   go-down


68. Beier JP, Jaeger K, Horch RE: Reduction mammaplasty for benign phyllodes tumour in an adolescent female--a 13-year follow up. Breast; 2006 Aug;15(4):550-3
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reduction mammaplasty for benign phyllodes tumour in an adolescent female--a 13-year follow up.
  • Phyllodes tumours are rare neoplasms of the female breast, especially among adolescent women.
  • We present the case of a 17-year old female patient with a large benign phyllodes tumour.
  • Symmetry of breast contour and nipple-areola complex position could be restored.
  • Standard plastic surgical techniques like reduction mammaplasty might be applied in treating large benign tumours compromising the aesthetic aspect of the breast.
  • [MeSH-major] Breast Neoplasms / surgery. Mammaplasty. Phyllodes Tumor / surgery

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • MedlinePlus Health Information. consumer health - Breast Reconstruction.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16310356.001).
  • [ISSN] 0960-9776
  • [Journal-full-title] Breast (Edinburgh, Scotland)
  • [ISO-abbreviation] Breast
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Cosmetics
  •  go-up   go-down


69. Franceschini G, D'Ugo D, Masetti R, Palumbo F, D'Alba PF, Mulè A, Costantini M, Belli P, Picciocchi A: Surgical treatment and MRI in phyllodes tumors of the breast: our experience and review of the literature. Ann Ital Chir; 2005 Mar-Apr;76(2):127-40
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment and MRI in phyllodes tumors of the breast: our experience and review of the literature.
  • AIMS: To reassess the relationship between magnetic resonance imaging (MRI) findings and surgical resection margins in an attempt to address the issue of appropriate surgical management of phyllodes tumors (PT).
  • METHODS: Three female patients with a large palpable mass suspicious for phyllodes tumors were studied by mammography (MX), ultrasound (US) and dynamic MRI and then underwent surgery.
  • Pathological results showed 1 case of benign phylloides tumor, 1 case of borderline phylloides tumor and 1 case of malignant phylloides tumor.
  • CONCLUSIONS: MRI enabled complete visualization of the tumor even in the region close to the chest wall, as well as clear delineation from healthy glandular tissue and may help to define the appropriate surgical management of phylloides tumor.
  • [MeSH-major] Breast Neoplasms / diagnosis. Breast Neoplasms / surgery. Magnetic Resonance Imaging. Phyllodes Tumor / diagnosis. Phyllodes Tumor / surgery
  • [MeSH-minor] Adult. Biopsy, Needle. Breast / pathology. Female. Follow-Up Studies. Humans. Mammography. Middle Aged. Palpation. Time Factors. Treatment Outcome. Ultrasonography, Mammary

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • MedlinePlus Health Information. consumer health - MRI Scans.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16302651.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Italy
  •  go-up   go-down


70. Jaka RC, Kumar KM, Gopinath KS: Spontaneous expulsion of benign phyllodes. Breast J; 2009 May-Jun;15(3):309
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spontaneous expulsion of benign phyllodes.
  • [MeSH-major] Breast Neoplasms / surgery. Phyllodes Tumor / surgery

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19645792.001).
  • [ISSN] 1524-4741
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


71. Bellolio J E, Guzmán G P, Orellana C J, Roa S JC, Villaseca H M, Araya O JC, Tapia E O, Ineda N V: [Diagnostic value of frozen section biopsy during surgery for breast lesions or neoplasms]. Rev Med Chil; 2009 Sep;137(9):1173-8
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnostic value of frozen section biopsy during surgery for breast lesions or neoplasms].
  • BACKGROUND: During the surgical treatment of breast neoplasms (benign or malignant), frozen section biopsy is frequently requested to assess the kind of lesion and determine the surgical margins.
  • AIM: To assess the diagnostic yield of frozen section breast biopsy.
  • MATERIAL AND METHODS: AH the pathological reports of frozen section biopsies and definitive biopsies of 337 women aged 26 to 88 years, operated for suspected breast neoplasms between 2002 and 2006, were reviewed.
  • The diagnosis of phyllodes tumor was missed by frozen section biopsy in three cases.
  • CONCLUSIONS: Frozen section biopsy is useful and reliable for cancer detection and margin status assessment in breast cancer surgery.
  • [MeSH-major] Biopsy / methods. Breast Neoplasms / pathology. Frozen Sections / standards. Intraoperative Care / methods

  • MedlinePlus Health Information. consumer health - Biopsy.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20011957.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Chile
  •  go-up   go-down


72. Lv S, Niu Y, Wei L, Liu Q, Wang X, Chen Y: Chromosomal aberrations and genetic relations in benign, borderline and malignant phyllodes tumors of the breast: a comparative genomic hybridization study. Breast Cancer Res Treat; 2008 Dec;112(3):411-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chromosomal aberrations and genetic relations in benign, borderline and malignant phyllodes tumors of the breast: a comparative genomic hybridization study.
  • Phyllodes tumors are not quite rare fibroepithelial neoplasms of the breast that show a broad spectrum of clinical behaviour.
  • We have used comparative genomic hybridization to analyze chromosomal copy number changes in 36 cases of phyllodes tumors (including benign, borderline and malignant phyllodes tumors, 12 cases each).
  • The average number of chromosome copy changes (range) in benign, borderline and malignant phyllodes tumors were 5.58 (0-20), 14.08 (3-23), and 12.42 (0-29) respectively.
  • In benign phyllodes tumors the number of gains and losses was in balance (2.50 vs 3.08), while in borderline and malignant phyllodes tumors gains occurred more often than losses (9.25 vs 4.83, 9.5 vs 2.92).
  • The result suggests the molecular cytogenetics of borderline and malignant phyllodes tumors is similar, and the most striking difference with benign phyllodes tumors is an increased number of chromosomal gains in a nonrandom distribution.
  • Gains of 4q12 seem especially to be involved in the progression of benign to borderline and malignant phyllodes tumors, possibly because of overexpression of oncogenes at these loci.
  • [MeSH-major] Breast Neoplasms / genetics. Chromosome Aberrations. Nucleic Acid Hybridization. Phyllodes Tumor / genetics

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18189161.001).
  • [ISSN] 1573-7217
  • [Journal-full-title] Breast cancer research and treatment
  • [ISO-abbreviation] Breast Cancer Res. Treat.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  •  go-up   go-down


73. Sorelli PG, Thomas D, Moore A, Khan M, Hoque H: Malignant phyllodes tumor in an 11-year-old premenarchal girl. J Pediatr Surg; 2010 Feb;45(2):e17-20
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant phyllodes tumor in an 11-year-old premenarchal girl.
  • Phyllodes tumor is uncommon in children, and the malignant form is rare.
  • There have only been a few cases of benign phyllodes tumor reported in peripubertal children and only one malignant case.
  • We report the second case of malignant phyllodes tumor in a premenarchal 11-year-old girl.
  • [MeSH-major] Breast Neoplasms / pathology. Breast Neoplasms / surgery. Phyllodes Tumor / pathology. Phyllodes Tumor / surgery
  • [MeSH-minor] Age Factors. Child. Diagnosis, Differential. Female. Humans. Menarche. Neoplasm Metastasis / pathology. Treatment Outcome

  • Genetic Alliance. consumer health - Phyllodes Tumor.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20152333.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


74. Kuo YJ, Ho DM, Tsai YF, Hsu CY: Invasive ductal carcinoma arising in phyllodes tumor with isolated tumor cells in sentinel lymph node. J Chin Med Assoc; 2010 Nov;73(11):602-4
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Invasive ductal carcinoma arising in phyllodes tumor with isolated tumor cells in sentinel lymph node.
  • Phyllodes tumor (PT) consists of stroma of variable grading and benign ductal epithelium.
  • Although exceptional, carcinomas that arise from the epithelium in PTs do exist, and seem to behave less aggressively than the usually encountered breast carcinoma.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / pathology. Lymph Nodes / pathology. Phyllodes Tumor / pathology. Sentinel Lymph Node Biopsy
  • [MeSH-minor] Adult. Female. Humans. Neoplasm Invasiveness

  • Genetic Alliance. consumer health - Phyllodes Tumor.
  • Genetic Alliance. consumer health - invasive ductal carcinoma.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright © 2010 Elsevier. Published by Elsevier B.V. All rights reserved.
  • (PMID = 21093830.001).
  • [ISSN] 1728-7731
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China (Republic : 1949- )
  •  go-up   go-down


75. Ben Hassouna J, Damak T, Gamoudi A, Chargui R, Khomsi F, Mahjoub S, Slimene M, Ben Dhiab T, Hechiche M, Boussen H, Rahal K: Phyllodes tumors of the breast: a case series of 106 patients. Am J Surg; 2006 Aug;192(2):141-7
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phyllodes tumors of the breast: a case series of 106 patients.
  • BACKGROUND: Phyllodes tumors (PTs) of the breast are rare, and their prognosis and treatment are still subject of discussion.
  • According to criteria of Azzopardi and Salvadori, tumors were classified into 3 groups: benign (62 cases, 58.4%), borderline (16 cases, 15%), and malignant (28 cases, 26.4%).
  • Eighty-two patients (77.4%) were treated conservatively (62 benign, 11 borderline, and 9 malignant) and 24 (22.6%) by radical surgery (5 borderline and 19 malignant).
  • For malignant PTs treated by enucleation or local excision with or without reexcision of the tumor bed, the 5-year overall and disease-free survivals were 28.5% and 15.6% versus 72.7% and 73.6% when the surgery was radical (mastectomy with or without axillary dissection) (P = .12 and P = .0022).
  • The rate of recurrence was 12.2% (13) after a mean follow-up of 39 months (5 benign, 2 borderline, and 5 malignant).
  • In univariate analysis, age and recurrences are not of prognostic value for survival, whereas tumor size, histotype, necrosis, cytonuclear atypia, tumor margins, and number of mitosis were significant prognostic factors for survival.
  • CONCLUSION: According to our results, we recommend for malignant PT a simple mastectomy, whereas for borderline and benign PT, treatment is based rather on wide excision passing in healthy tissue.
  • [MeSH-major] Breast Neoplasms / diagnosis. Mastectomy / methods. Phyllodes Tumor / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Diagnosis, Differential. Disease-Free Survival. Female. Follow-Up Studies. Humans. Mammography. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Rate. Ultrasonography, Mammary

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • MedlinePlus Health Information. consumer health - Mastectomy.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16860620.001).
  • [ISSN] 0002-9610
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


76. Hino N, Nakagawa Y, Ikushima Y, Yoshida M, Tsuyuguchi M: A case of a giant phyllodes tumor of the breast with hypoglycemia caused by high-molecular-weight insulin-like growth factor II. Breast Cancer; 2010 Apr;17(2):142-5
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of a giant phyllodes tumor of the breast with hypoglycemia caused by high-molecular-weight insulin-like growth factor II.
  • We report the case of a patient who presented with hypoglycemia associated with a giant breast mass and presence of serum high-molecular-weight insulin-like growth factor II (big IGF-II).
  • In July 2005, a 49-year-old woman was admitted because of delirium, transient loss of consciousness, and a giant mass of about 28 cm in diameter on the right breast.
  • Because we suspected that the big IGF-II was produced by the breast tumor and was likely the cause of the hypoglycemia, a mastectomy was performed.
  • A histological examination determined that the mass was a benign phyllodes tumor.
  • We suspected that the patient had non-islet cell tumor hypoglycemia (NICTH), but the behavioral symptoms of the hypoglycemia caused by NICTH were similar to some mental diseases, which made diagnosis based on the behavior alone difficult.
  • We suggest that co-occurrence of symptoms such as recent appearance of mental disease-like behavior, hypoglycemia, and giant breast tumor may help diagnose NICTH caused by big IGF-II.
  • [MeSH-major] Breast Neoplasms / etiology. Hypoglycemia / etiology. Insulin-Like Growth Factor II / metabolism. Phyllodes Tumor / etiology


77. Wurdinger S, Herzog AB, Fischer DR, Marx C, Raabe G, Schneider A, Kaiser WA: Differentiation of phyllodes breast tumors from fibroadenomas on MRI. AJR Am J Roentgenol; 2005 Nov;185(5):1317-21
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differentiation of phyllodes breast tumors from fibroadenomas on MRI.
  • OBJECTIVE: The purpose of our study was to evaluate the MRI appearance of phyllodes breast tumors and to differentiate them from fibroadenomas.
  • MR images of 23 patients with 24 phyllodes breast tumors (one malignant, 23 benign) were analyzed with respect to morphology and contrast enhancement.
  • RESULTS: Well-defined margins were seen in 87.5% of the phyllodes tumors and 70.4% of the fibroadenomas, and a round or lobulated shape in 100% and 90.1%, respectively.
  • A heterogeneous internal structure was observed in 70.8% of phyllodes tumors and in 49.4% of fibroadenomas.
  • Nonenhancing internal septations were found in 45.8% of phyllodes tumors and 27.2% of fibroadenomas.
  • A significantly greater increase in signal was seen on T2-weighted images in the tissue surrounding phyllodes tumors (21%) compared with fibroadenomas (1.2%).
  • After the administration of contrast material, 33.3% of phyllodes tumors and 22.2% of fibroadenomas showed a suspicious signal intensity-time course.
  • CONCLUSION: Phyllodes breast tumors and other fibroadenomas cannot be precisely differentiated on breast MRI.
  • Phyllodes tumors have benign morphologic features and contrast enhancement characteristics suggestive of malignancy in 33% of cases.
  • [MeSH-major] Breast Neoplasms / diagnosis. Fibroadenoma / diagnosis. Magnetic Resonance Imaging. Phyllodes Tumor / diagnosis

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • MedlinePlus Health Information. consumer health - MRI Scans.
  • Hazardous Substances Data Bank. GADOPENTETATE DIMEGLUMINE .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16247156.001).
  • [ISSN] 0361-803X
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
  •  go-up   go-down


78. Aron M, Ray R, Verma K: Pseudoangiomatous stromal hyperplasia of the breast-cytological features of two cases and review of literature. Indian J Pathol Microbiol; 2005 Apr;48(2):260-4
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pseudoangiomatous stromal hyperplasia of the breast-cytological features of two cases and review of literature.
  • Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a lesion characterized on histology by the presence of anastomosing slit like spaces embedded in a hyalinized fibrous stroma.
  • Till date, the cytological features of PASH have been described in only 12 cases, of which two cases were diagnosed on aspiration cytology as suspicious for carcinoma and in one case, for phyllodes tumor.
  • The first case was diagnosed as a phyllodes tumor and the other case as a benign proliferative breast disease, possibly a fibroadenoma.
  • FNAC findings of PASH are non-specific, and the role of FNAC in PASH is to confirm the benign nature of the lesion, rather than provide a definitive pre-surgical diagnosis.
  • [MeSH-major] Angiomatosis / pathology. Breast Diseases / pathology. Hyperplasia / pathology. Stromal Cells / pathology
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Breast. Breast Neoplasms / pathology. Diagnosis, Differential. Female. Fibroadenoma / pathology. Humans. Phyllodes Tumor / pathology

  • Genetic Alliance. consumer health - Pseudoangiomatous stromal hyperplasia.
  • MedlinePlus Health Information. consumer health - Breast Diseases.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] Indian J Pathol Microbiol. 2010 Jul-Sep;53(3):573-4 [20699535.001]
  • (PMID = 16758690.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 12
  •  go-up   go-down


79. Giri D: Recurrent challenges in the evaluation of fibroepithelial lesions. Arch Pathol Lab Med; 2009 May;133(5):713-21
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CONTEXT: The morphologic spectrum of mammary fibroepithelial lesions ranges from fibroadenoma, a common benign neoplasm, to phyllodes tumor, an uncommon lesion that can sometimes recur and metastasize.
  • DATA SOURCES: A PubMed search of the English-language literature identified published reports on fibroepithelial lesions, with a special focus on phyllodes tumor.
  • CONCLUSIONS: The distinction between fibroadenoma and phyllodes tumor is usually not problematic, especially in excision specimens.
  • Morphologic predictors of local recurrence of phyllodes tumor include cellularity and cytologic atypia, mitotic activity, positive margins, infiltrative borders, fibroproliferative satellite nodules, and past history of fibroadenoma.
  • Predictors of distant metastasis include size, tumor necrosis, and stromal overgrowth.
  • [MeSH-major] Breast Neoplasms / diagnosis. Fibroadenoma / diagnosis. Phyllodes Tumor / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. DNA, Neoplasm / analysis. Diagnosis, Differential. Female. Gene Expression. Humans. Immunoenzyme Techniques. Neoplasm Recurrence, Local

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19415945.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm
  • [Number-of-references] 46
  •  go-up   go-down


81. Ilić I, Randelović P, Ilić R, Katić V, Milentijević M, Velicković L, Krstić M: An approach to malignant mammary phyllodes tumors detection. Vojnosanit Pregl; 2009 Apr;66(4):277-82
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An approach to malignant mammary phyllodes tumors detection.
  • BACKGROUND/AIM: Mammary phyllodes tumors (MPT) are uncommon fibroepithelial (biphasic) neoplasms whose clinical behavior is difficult to predict on the basis of histological criteria only.
  • They are divided into benign, borderline malignant and malignant groups.
  • A total of 35 cases of MPT were included: 20 benign (57%), 6 borderline malignant (17%) and 9 malignant (26%).
  • The mean size of malignant MPT (7.8 cm) was larger than that of benign MPT (4.5 cm).
  • Significant features of the malignant MPT were: stromal cellularity, stromal cellular atypism, high mitotic activity, atypic mitoses, stromal overgrowth, infiltrative tumor contour and heterologous stromal elements.
  • Benign MPT showed strong enzymohistochemical Leucine Amino Peptidase (LAP) activity in both epithelial and stromal components while it was weak or absent in the epithelial parts of the malignant tumors.
  • Benign MPT had a lower Ki-67 than did borderline malignant MPT (4 versus 28).
  • Malignant MPT had a greater than 8-fold higher Ki-67 activity than did benign tumors (35 versus 4).
  • [MeSH-major] Breast Neoplasms / diagnosis. Phyllodes Tumor / diagnosis
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Ki-67 Antigen / analysis. Middle Aged. Receptors, Estrogen / analysis

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19441158.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Serbia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Receptors, Estrogen
  •  go-up   go-down


82. Manfrin E, Mariotto R, Remo A, Reghellin D, Falsirollo F, Dalfior D, Bricolo P, Piazzola E, Bonetti F: Benign breast lesions at risk of developing cancer--a challenging problem in breast cancer screening programs: five years' experience of the Breast Cancer Screening Program in Verona (1999-2004). Cancer; 2009 Feb 1;115(3):499-507
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign breast lesions at risk of developing cancer--a challenging problem in breast cancer screening programs: five years' experience of the Breast Cancer Screening Program in Verona (1999-2004).
  • BACKGROUND: Cytology and core-needle biopsies are not always sufficient to exclude malignancy in benign breast lesions (BBL) that are at risk of developing cancer, and open biopsy often is mandatory.
  • In screening programs, open biopsies performed for lesions that are at risk of developing malignancy are considered benign.
  • The authors of this report evaluated the impact of the screen-detected BBL at risk of developing cancer that were counted in the quota of benign breast open biopsies in the Breast Cancer Screening Program of Verona.
  • METHODS: Benign open biopsies were subdivided into 4 groups according to their risk of developing cancer: Histo1, normal histology; Histo2, 'pure' BBL (fibroadenoma, fibrocystic disease, mastitis, adenosis); Histo3, BBL with a low risk of developing cancer (radial scar, papilloma, papillomatosis, phyllodes tumor, mucocele-like lesion); and Histo4, BBL with a high risk of developing cancer (atypical columnar cell hyperplasia, atypical ductal hyperplasia, atypical lobular hyperplasia).
  • RESULTS: Of 510 open biopsies, 83 biopsies were benign, and the ratio of benign to malignant biopsies was 1:5.
  • Histo1 was observed in 4.8% of all benign open biopsies, Histo2 was observed in 37.4%, Histo3 was observed in 31.3%, and Histo4 was observed 26.5%.
  • It is inappropriate to include BBL at risk of developing cancer in the overall benign open biopsy rate.
  • [MeSH-major] Biopsy / methods. Breast Diseases / complications. Breast Neoplasms / diagnosis


83. Tse GM, Chaiwun B, Lau KM, Scolyer R, Lee CS, Karim RZ, Putti TC, Law BK, Lui PC, Tan PH: Endothelin-1 expression correlates with atypical histological features in mammary phyllodes tumours. J Clin Pathol; 2007 Sep;60(9):1051-6
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endothelin-1 expression correlates with atypical histological features in mammary phyllodes tumours.
  • This has not been evaluated in phyllodes tumours, which are uncommon fibroepithelial lesions with potential for local recurrences or distant metastasis.
  • While the grading of phyllodes tumours depends on a combination of histological parameters, prediction of their behaviour remains difficult.
  • METHOD: A large series of 461 phyllodes tumours (291 benign, 115 borderline malignant and 55 frankly malignant) were evaluated for endothelin-1 expression in both the epithelial cells and stromal cells by immunohistochemistry; results were correlated with the tumour grade.
  • RESULTS: For benign phyllodes tumours, the epithelial staining of endothelin was negative, weak, moderate and strong in 6%, 26%, 15% and 53% of cases respectively; results were 4%, 18%, 19% and 59% respectively for borderline and 6%, 18%, 6% and 70% respectively for frankly malignant tumours.
  • For the stromal staining, the negative, weak, moderate and strong staining was 32%, 19%, 18% and 31% respectively for benign phyllodes, 24%, 13%, 10% and 53% respectively for borderline and 8%, 16%, 17% and 59% respectively for frankly malignant tumours.
  • CONCLUSION: These observations suggest a close relationship between the epithelial and stromal elements in phyllodes tumours; endothelin may play a significant role in the malignant progression of phyllodes tumours.
  • [MeSH-major] Breast Neoplasms / metabolism. Endothelin-1 / metabolism. Neoplasm Proteins / metabolism. Phyllodes Tumor / metabolism

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Histopathology. 1995 Sep;27(3):205-18 [8522284.001]
  • [Cites] Cancer. 1996 Mar 1;77(5):910-6 [8608483.001]
  • [Cites] J Biol Chem. 2002 Aug 2;277(31):27850-5 [12023962.001]
  • [Cites] Nature. 1988 Mar 31;332(6163):411-5 [2451132.001]
  • [Cites] FEBS Lett. 1988 Apr 25;231(2):440-4 [3282927.001]
  • [Cites] J Biol Chem. 1989 May 15;264(14):7856-61 [2542249.001]
  • [Cites] Surg Gynecol Obstet. 1990 Mar;170(3):193-6 [2154867.001]
  • [Cites] J Surg Oncol. 1990 Sep;45(1):46-51 [2166186.001]
  • [Cites] J Exp Med. 1990 Dec 1;172(6):1741-8 [1701822.001]
  • [Cites] Cancer. 1992 Jan 1;69(1):141-7 [1309302.001]
  • [Cites] Cancer Res. 1999 Feb 1;59(3):720-7 [9973223.001]
  • [Cites] Pathol Res Pract. 1998;194(2):97-104 [9584322.001]
  • [Cites] Cancer Res. 1992 Jul 15;52(14):4046-9 [1319837.001]
  • [Cites] Eur J Pharmacol. 1999 Jun 30;375(1-3):133-8 [10443571.001]
  • [Cites] Histopathology. 1999 Aug;35(2):162-9 [10460662.001]
  • [Cites] Pathol Int. 1999 Sep;49(9):807-10 [10504552.001]
  • [Cites] Am J Clin Pathol. 2005 Apr;123(4):529-40 [15743740.001]
  • [Cites] Cancer Lett. 2005 May 26;222(2):129-38 [15863261.001]
  • [Cites] Br J Cancer. 2005 May 9;92(9):1720-8 [15841074.001]
  • [Cites] Surg Oncol. 1995;4(6):309-15 [8809953.001]
  • [Cites] Histopathology. 2000 Feb;36(2):161-7 [10672062.001]
  • [Cites] Genomics. 2000 Feb 15;64(1):51-61 [10708518.001]
  • [Cites] Am J Respir Cell Mol Biol. 2000 Apr;22(4):422-31 [10745023.001]
  • [Cites] BJU Int. 2000 Apr;85 Suppl 2:45-8 [10781185.001]
  • [Cites] Eur J Immunol. 2002 Sep;32(9):2393-400 [12207323.001]
  • [Cites] Cancer Chemother Pharmacol. 2003 Jan;51(1):21-8 [12497202.001]
  • [Cites] Mol Cancer Ther. 2002 Dec;1(14):1273-81 [12516960.001]
  • [Cites] Nat Rev Cancer. 2003 Feb;3(2):110-6 [12563310.001]
  • [Cites] J Pathol. 2003 May;200(1):59-64 [12692842.001]
  • [Cites] Clin Cancer Res. 2003 Sep 15;9(11):4125-31 [14519635.001]
  • [Cites] Mod Pathol. 2003 Oct;16(10):1007-13 [14559983.001]
  • [Cites] Cancer Res. 2004 Apr 1;64(7):2461-8 [15059899.001]
  • [Cites] Mod Pathol. 2004 Jul;17(7):827-31 [15044924.001]
  • [Cites] Hum Pathol. 2004 Sep;35(9):1053-7 [15343505.001]
  • [Cites] Radiology. 1983 Feb;146(2):481-6 [6294737.001]
  • [Cites] J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S1-4 [11078319.001]
  • [Cites] Annu Rev Pharmacol Toxicol. 2001;41:851-76 [11264479.001]
  • [Cites] Mod Pathol. 2002 Jul;15(7):734-40 [12118111.001]
  • [Cites] Am J Surg. 1993 Mar;165(3):376-9 [8383473.001]
  • [Cites] Eur J Cancer. 1993;29A(9):1252-6 [8393684.001]
  • (PMID = 17158636.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Endothelin-1; 0 / Neoplasm Proteins
  • [Other-IDs] NLM/ PMC1972415
  •  go-up   go-down


84. Trabelsi A, Abdelkrim SB, Hammedi F, Sahraoui W, Abdelkader AB, Sriha B, Mokni M: Synchronous Bilateral Benign Phyllodes Tumor of the Breast in a 32-year-old Woman. World J Oncol; 2010 Feb;1(1):45-46
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous Bilateral Benign Phyllodes Tumor of the Breast in a 32-year-old Woman.
  • Bilateral phyllodes tumors are distinctly uncommon.
  • We report a new case of bilateral synchronous phyllodes tumor in a 32-year-old women.
  • Both tumors were classified as benign after large bilateral excision.
  • No tumor recurrence was noted during the 10 months follow-up.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Isr J Med Sci. 1981 Sep-Oct;17(9-10):895-8 [6273359.001]
  • [Cites] Ann Diagn Pathol. 2000 Dec;4(6):370-2 [11149968.001]
  • [Cites] J Surg Oncol. 1991 Jan;46(1):67-9 [1846015.001]
  • [Cites] Arch Pathol Lab Med. 2006 Oct;130(10):1516-21 [17090194.001]
  • [Cites] Chir Ital. 2008 Nov-Dec;60(6):867-72 [19256279.001]
  • [Cites] J Postgrad Med. 1985 Oct;31(4):215-6 [3009798.001]
  • (PMID = 29147179.001).
  • [ISSN] 1920-454X
  • [Journal-full-title] World journal of oncology
  • [ISO-abbreviation] World J Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Keywords] NOTNLM ; Breast / Phyllodes tumor / Synchronous bilateral tumors
  •  go-up   go-down


85. Morgan JM, Douglas-Jones AG, Gupta SK: Analysis of histological features in needle core biopsy of breast useful in preoperative distinction between fibroadenoma and phyllodes tumour. Histopathology; 2010 Mar;56(4):489-500
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of histological features in needle core biopsy of breast useful in preoperative distinction between fibroadenoma and phyllodes tumour.
  • AIMS: Fine Needle Aspiration Cytology (FNAC) has been replaced by Needle core biopsy (NCB) as the pathological investigation of choice in pre-operative diagnosis of breast lesions.
  • Despite the greater yield of material with spatial information, the distinction between fibroepithelial lesions of the breast, fibroadenoma (FA) and benign phyllodes tumour (PT), remains problematic.
  • METHODS: Previously defined histological criteria were applied to 112 NCBs of fibroepithelial lesions of the breast.
  • [MeSH-major] Biopsy, Needle / methods. Breast Neoplasms / pathology. Fibroadenoma / pathology. Phyllodes Tumor / pathology

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20459556.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  •  go-up   go-down


86. Dillon MF, Quinn CM, McDermott EW, O'Doherty A, O'Higgins N, Hill AD: Needle core biopsy in the diagnosis of phyllodes neoplasm. Surgery; 2006 Nov;140(5):779-84
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Needle core biopsy in the diagnosis of phyllodes neoplasm.
  • BACKGROUND: Accurate identification of phyllodes neoplasms without surgical intervention is difficult, reducing the ability to manage "benign" lumps non-operatively and impacting on the open benign biopsy rate.
  • Needle core biopsy is considered to be a highly accurate technique in the diagnosis of breast carcinoma.
  • Its accuracy in the diagnosis of phyllodes neoplasm has not been established.
  • RESULTS: Twenty-three patients had phyllodes neoplasm on excisional biopsy with prior core biopsy findings as follows: phyllodes neoplasm (n=2), "equivocal" for phyllodes neoplasm (n=12), fibroadenoma (n=3), benign (n=6).
  • The false negative rate for phyllodes neoplasm was therefore 39% (n=9/23).
  • Of the total biopsy series, 35 patients had a core biopsy suggesting the possibility of phyllodes neoplasm.
  • Of these, 32% (n=11) were found to be phyllodes neoplasm on excision, 3% (n=1) phyllodes neoplasm with breast carcinoma, 6% (n=2) breast carcinoma, and 3% (n=1) sarcoma.
  • When a preference for phyllodes neoplasm (n=4) was stated on the equivocal core biopsies, excision correlated with the stated preference; this correlation also occurred in 90% (n=9/10) of core biopsies where fibroadenoma was favored.
  • CONCLUSIONS: Needle core biopsy rarely produces a definite preoperative diagnosis of phyllodes neoplasm.
  • A diagnosis of fibroadenoma or equivocal phyllodes neoplasm on core biopsy should not prevent excision if clinical suspicion remains.
  • [MeSH-major] Biopsy, Needle / methods. Breast Neoplasms / diagnosis. Diagnostic Errors. Phyllodes Tumor / diagnosis

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17084721.001).
  • [ISSN] 0039-6060
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


87. Fang Y, Gao JD, Tian YT, Xie YQ, Zhen S: [Analysis of the treatment and prognosis of recurrent breast phyllodes tumor]. Zhonghua Zhong Liu Za Zhi; 2009 Jan;31(1):72-4
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Analysis of the treatment and prognosis of recurrent breast phyllodes tumor].
  • OBJECTIVE: To explore the methods of diagnosis, treatment and prognosis for patients with recurrent breast phyllodes tumor.
  • METHODS: Clinicopathological data of 26 patients with pathologically proven recurrent phyllodes tumors treated from March 1972 to June 2006 were retrospectively analyzed.
  • The primary breast phyllodes tumor was > or = 5 cm in 10 cases with a recurrence rate of 60.0% (6/10 cases); < 5 cm in 16 cases with a recurrence rate of 31.3% 5/16 cases).
  • After surgical removal of the breast primary tumor, the recurrent tumor was > or = 5 cm in 14 cases with a re-recurrence rate of 35.7% (5/14 cases); < 5 cm was in 12 cases with are-recurrence rate of 50.0% (6/12 cases).
  • There was no statistically significant relationship between the (primary and reccurent) tumor size and recurrence rate (P = 0.094, P = 0.383) or prognosis (P = 0.142, P = 0.486).
  • The benign or malignant nature of the breast phyllodes tumor was significantly correlated with the rate of local re-recurrence (P = 0.046) and prognosis (P = 0.028).
  • CONCLUSION: The benign or malignant nature of the breast phyllodes tumor is significantly correlated with the local re-recurrence and prognosis, while the size of the primary breast phyllodes tumor has no significant effect on either re-recrruence or prognosis.
  • The first rescue operation is most important in the treatment of recurrent breast phyllodes tumor.
  • Active surgical treatment can still effectively save the life of the patients with a local re-recurrent tumor.
  • [MeSH-major] Breast Neoplasms / surgery. Mastectomy / methods. Neoplasm Recurrence, Local / surgery. Phyllodes Tumor / surgery
  • [MeSH-minor] Adolescent. Adult. Chemotherapy, Adjuvant. Child. Female. Follow-Up Studies. Humans. Middle Aged. Prognosis. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate. Tumor Burden. Young Adult

  • Genetic Alliance. consumer health - Phyllodes Tumor.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • MedlinePlus Health Information. consumer health - Mastectomy.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19538877.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  •  go-up   go-down


88. Chen SJ, Cheng KS, Dai YC, Sun YN, Chen YT, Chang KY, Yu SN, Chang TW, Tsai HM, Hsien CC: Quantitatively characterizing the textural features of sonographic images for breast cancer with histopathologic correlation. J Ultrasound Med; 2005 May;24(5):651-61
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Quantitatively characterizing the textural features of sonographic images for breast cancer with histopathologic correlation.
  • A statistical feature matrix was applied to quantify the texture difference (ie, the dissimilarity) of the sonographic images for malignant and benign breast tumors.
  • CONCLUSIONS: From the experimental results, it is shown that the cellular and fibrous content with spatial distribution of breast masses determine the dissimilarity values on sonographic images.
  • [MeSH-major] Breast Neoplasms / pathology. Breast Neoplasms / ultrasonography. Image Processing, Computer-Assisted. Ultrasonography, Mammary
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy, Fine-Needle. Carcinoma, Ductal, Breast / pathology. Carcinoma, Ductal, Breast / surgery. Carcinoma, Ductal, Breast / ultrasonography. Carcinoma, Intraductal, Noninfiltrating / pathology. Carcinoma, Intraductal, Noninfiltrating / surgery. Carcinoma, Intraductal, Noninfiltrating / ultrasonography. Confidence Intervals. Diagnosis, Differential. Female. Fibroadenoma / pathology. Fibroadenoma / surgery. Fibroadenoma / ultrasonography. Humans. Mastectomy / methods. Middle Aged. Phyllodes Tumor / pathology. Phyllodes Tumor / surgery. Phyllodes Tumor / ultrasonography

  • Genetic Alliance. consumer health - Breast Cancer.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15840797.001).
  • [ISSN] 0278-4297
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  •  go-up   go-down


89. Suzuki-Uematsu S, Shiraishi K, Ito T, Adachi N, Inage Y, Taeda Y, Ueki H, Ohtani H: Malignant phyllodes tumor composed almost exclusively of a fibrosarcomatous component: a case report and review of malignant phyllodes tumors with metastases. Breast Cancer; 2010 Jul;17(3):218-24
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant phyllodes tumor composed almost exclusively of a fibrosarcomatous component: a case report and review of malignant phyllodes tumors with metastases.
  • Here we present a case of malignant phyllodes tumor which was composed almost exclusively of a fibrosarcomatous component.
  • A 52-year-old Japanese female noted a rapid increase of her right breast tumor.
  • The tumor, 10 x 10 cm in the largest dimension, had somewhat of a pushing margin, and showed a flesh-like appearance with marked necrosis.
  • Microscopically, the tumor showed proliferation of atypical ovoid- or spindle-shaped cells in a myxoid matrix.
  • Multiple sectioning revealed that the tumor had only focal occurrence of elongated tubular structures, and the occurrence of a small component of benign phyllodes tumor, leading to the aforementioned final diagnosis.
  • We reviewed 15 malignant phyllodes tumors with metastases reported in Japan.
  • [MeSH-major] Breast Neoplasms / pathology. Fibrosarcoma / pathology. Lung Neoplasms / secondary. Phyllodes Tumor / secondary

  • Genetic Alliance. consumer health - Phyllodes Tumor.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • MedlinePlus Health Information. consumer health - Lung Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19350353.001).
  • [ISSN] 1880-4233
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  •  go-up   go-down


90. Kinkor Z, Skálová A, Michal M, Janousek M, Kheck M: [Metastasing and relapsing "low grade" adenosquamous metaplastic breast cancer--is there a really indolent lesion? A description of three cases and review of literature]. Ceska Gynekol; 2005 May;70(3):211-6
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Metastasing and relapsing "low grade" adenosquamous metaplastic breast cancer--is there a really indolent lesion? A description of three cases and review of literature].
  • OBJECTIVE: To describe personnel experience with three unusual cases of low-grade adenosquamous carcinoma of the breast.
  • RESULTS: Partial mastectomy and segmentectomy were performed in three women 46, 72 and 74 years-old resp. for tumor, which size ranged from 20-35 mm in maximum diameter (mean 28 mm).
  • There were recognized metastases by one woman in two ipsilateral axillary lymph nodes mimicking benign breast heterotopia in one of them.
  • In two women with aggressive course the original biopsy was falsely interpreted, once as phyllodes tumor and secondly as benign sclerosing pseudotumor.
  • It arises in the deep breast tissue and structurally resembles the microcystic adnexal carcinoma of the skin.
  • Low-grade adenosquamous carcinoma, however, has nothing to do with syringomatous adenoma of the nipple, which is a benign tumor of the skin adnexa.
  • Differential diagnosis includes spectrum of non-neoplastic slerosing lesions and above-mentioned phylloid tumor.
  • The rarity of this neoplasm does not exclude deep knowledge.


91. Agarwal P, Sparnon AL: Benign breast lesions in adolescent girls: an overview with a case report. Pediatr Surg Int; 2005 May;21(5):381-2
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign breast lesions in adolescent girls: an overview with a case report.
  • A wide spectrum of breast disorders occurs in the paediatric and adolescent age groups, but malignant disease is very rare.
  • We report a case in an adolescent girl that was initially diagnosed and treated as fibroadenoma until a histological assessment proved it to be a phyllodes tumour with malignant potential.
  • [MeSH-major] Breast Neoplasms / diagnosis. Phyllodes Tumor / diagnosis
  • [MeSH-minor] Adolescent. Breast Diseases / diagnosis. Female. Fibroadenoma / diagnosis. Humans

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Am J Surg. 1983 Dec;146(6):712-4 [6316797.001]
  • [Cites] Cancer. 1978 May;41(5):1974-83 [206344.001]
  • [Cites] South Med J. 1986 May;79(5):543-7 [3010475.001]
  • [Cites] Semin Diagn Pathol. 1999 Aug;16(3):235-47 [10490200.001]
  • [Cites] Pediatr Surg Int. 1999 Jul;15(5-6):427-8 [10415310.001]
  • (PMID = 15742186.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


92. Taira N, Takabatake D, Aogi K, Ohsumi S, Takashima S, Nishimura R, Teramoto N: Phyllodes tumor of the breast: stromal overgrowth and histological classification are useful prognosis-predictive factors for local recurrence in patients with a positive surgical margin. Jpn J Clin Oncol; 2007 Oct;37(10):730-6
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phyllodes tumor of the breast: stromal overgrowth and histological classification are useful prognosis-predictive factors for local recurrence in patients with a positive surgical margin.
  • BACKGROUND: The local recurrence rate of phyllodes tumors is high and ensuring a sufficient surgical margin is considered important for local control.
  • However, the preoperative diagnosis rate of phyllodes tumors is low and we often encounter cases in which a sufficient surgical margin is not achieved, since in routine medical practice the lesion may not be diagnosed as phyllodes tumor until postoperative biopsy of a mammary mass.
  • Furthermore, there are no established therapeutic guidelines for surgical stump-positive phyllodes tumors.
  • We reviewed the outcomes of excision of phyllodes tumors to investigate factors involved in local recurrence and to determine the indication for re-excision in stump-positive cases.
  • METHODS: The subjects were 45 patients treated for phyllodes tumors at our institution from January 1980 to July 2005.
  • Age, tumor size, surgical method, stromal cellular atypia, mitotic activity, stromal overgrowth, histological classification and surgical stump status were analyzed.
  • RESULTS: Median age was 45 years old (range 28-75) and tumor size was 1-17 cm (median 3.5 cm).
  • Pathologic diagnoses were benign, borderline and malignant in 31, five and nine cases, respectively, and the surgical stump was negative in 27 lesions and positive in 15.
  • In univariate analysis, a positive surgical margin, stromal overgrowth and histological classification were predictive factors for local recurrence after breast-conservation surgery (P = 0.0034, 0.0003, 0.026).
  • CONCLUSION: Wide excision is the preferred therapy for phyllodes tumor and preoperative diagnosis is important for good local control.
  • [MeSH-major] Breast Neoplasms / pathology. Breast Neoplasms / surgery. Neoplasm Recurrence, Local / prevention & control. Phyllodes Tumor / pathology. Phyllodes Tumor / surgery

  • Genetic Alliance. consumer health - Phyllodes Tumor.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17932112.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


93. Shah SN: Giant myofibroblastoma of breast: a case report. Indian J Pathol Microbiol; 2007 Jul;50(3):583-5
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant myofibroblastoma of breast: a case report.
  • Myofibroblastoma of the breast is a very rare benign neoplasm usually seen in elderly male and is of very small size.
  • A 40 year old nulliparous woman was admitted with chief complain of massive enlargement of left breast.
  • The case was clinically diagnosed as Phyllodes tumor Left mastectomy was done.
  • The tumor was histopathologically and immunohistochemically diagnosed as Myofibroblastoma.
  • [MeSH-major] Breast Neoplasms / diagnosis. Neoplasms, Muscle Tissue / diagnosis

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17883145.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  •  go-up   go-down


94. Akin M, Irkorucu O, Koksal H, Gonul II, Gultekin S, Kurukahvecioglu O, Anadol AZ, Tekin E: Phyllodes tumor of the breast; a case series. Bratisl Lek Listy; 2010;111(5):271-4
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phyllodes tumor of the breast; a case series.
  • BACKGROUND: Phyllodes tumor (PT) is a rare neoplasm comprising less than 1% of all breast tumors.
  • Its clinical spectrum ranges from a benign and locally recurrent form of behavior to malignant and metastatic forms.
  • All cases were histologically examined by an experienced breast pathologist, and tumors were classified as benign, borderline malignant or malignant according to standard histological criteria.
  • Seven (70%) of 10 tumors were benign and 3 (30%) were malignant.
  • The median tumor size was 29 mm (range: 12-80 mm).
  • CONCLUSION: PT is a rare neoplasm of the breast.
  • [MeSH-major] Breast Neoplasms. Phyllodes Tumor

  • Genetic Alliance. consumer health - Phyllodes Tumor.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20568416.001).
  • [ISSN] 0006-9248
  • [Journal-full-title] Bratislavské lekárske listy
  • [ISO-abbreviation] Bratisl Lek Listy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovakia
  •  go-up   go-down


95. El Hag IA, Aodah A, Kollur SM, Attallah A, Mohamed AA, Al-Hussaini H: Cytological clues in the distinction between phyllodes tumor and fibroadenoma. Cancer Cytopathol; 2010 Feb 25;118(1):33-40
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytological clues in the distinction between phyllodes tumor and fibroadenoma.
  • BACKGROUND: Fine-needle aspiration (FNA) sensitivity in discriminating between phyllodes tumor and its benign mimicker fibroadenoma (FA) remains low.
  • Because a preoperative categorization of phyllodes tumor is crucial for their appropriate management, the authors undertook this study in an effort to improve the outcome of FNA by identifying reliable distinguishing features.
  • METHODS: FNA smears from 15 and 12 histologically proven cases of phyllodes tumor and FA, respectively, were reviewed.
  • A group of cytological features that may distinguish between phyllodes tumor and FA were identified.
  • Their value and reproducibility in categorizing phyllodes tumor cases were tested.
  • RESULTS: Three major cytological features were exclusively seen in all of, or the vast majority of, the phyllodes tumor cases; fibromyxoid stromal fragments with spindle nuclei (90%), fibroblastic pavements (93%), and appreciable number of spindles cells of fibroblastic nature among dispersed cell population (100%).
  • The identification of these features improved the pick-up rate of phyllodes tumor from 40% to 100% and had substantial (kappa = 0.56-0.73) interobserver and almost perfect (kappa = 0.83) intraobserver reproducibility.
  • There was no significant difference in the epithelial component characteristics between phyllodes tumor and FA.
  • The frequency and degree of atypia in the dispersed cell population correlated well to the histological grade of phyllodes tumor.
  • CONCLUSIONS: FNA has proven to be a reliable test in differentiating between phyllodes tumor and FA with high sensitivity and good reproducibility.
  • [MeSH-major] Breast Neoplasms / diagnosis. Fibroadenoma / diagnosis. Phyllodes Tumor / diagnosis

  • Genetic Alliance. consumer health - Phyllodes Tumor.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] (c) 2010 American Cancer Society.
  • (PMID = 20094997.001).
  • [ISSN] 1934-662X
  • [Journal-full-title] Cancer cytopathology
  • [ISO-abbreviation] Cancer Cytopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


96. Gojnic M, Dugalic V, Vidaković S, Papic M, Jeremic K, Pervulov M, Milicevic S: Breast cancer and borderline ovarian carcinoma in young patients--case report. Eur J Gynaecol Oncol; 2005;26(5):579-80
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Breast cancer and borderline ovarian carcinoma in young patients--case report.
  • Cystosarcoma phyloides is a breast cancer with deterrent features because of its size and fast growth.
  • Regardless of the tumor type (serous, mucinous, clear cell, Brenner, mixed) they can be benign, borderline or malignant.
  • [MeSH-major] Breast Neoplasms / diagnosis. Ovarian Neoplasms / diagnosis. Phyllodes Tumor / diagnosis


97. Rodríguez Ogando A, Fernández López T, Rodríguez Castaño MJ, Mata Fernández C, Alvarez Bernardi J, Cebollero Presmanes M: Cystosarcoma phyllodes of the breast: a case report in a 12-year-old girl. Clin Transl Oncol; 2010 Oct;12(10):704-6
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystosarcoma phyllodes of the breast: a case report in a 12-year-old girl.
  • Breast tumors in adolescents are very rare and mostly benign.
  • Fibroadenomas are the most frequent, but within the extensive differential diagnosis, the phyllodes tumor must be mentioned, which accounts for about 1% of breast tumors and the diagnosis of which is very rare in patients younger than 20 years.
  • There are no specific symptoms or radiological images to distinguish phyllodes tumor from fibroadenoma; therefore, histological examination is mandatory for diagnosis.
  • Histology also allows the classification of phyllodes tumor into benign, borderline, or malignant types for appropriate surgical treatment: freemargin excision in benign tumors and mastectomy in the other two types.
  • Fortunately, the majority of these tumors are benign, and treatment maximizes breast conservation with free infiltration margins surgery, given that this fact is the most important factor to prevent local recurrence.
  • In this article, we describe a rare case of borderline cystosarcoma phyllodes in a 12-year-old girl.
  • [MeSH-major] Breast Neoplasms / pathology. Phyllodes Tumor / pathology

  • Genetic Alliance. consumer health - Phyllodes Tumor.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Cancer. 2000 Oct 1;89(7):1502-11 [11013364.001]
  • [Cites] J Clin Pathol. 2006 May;59(5):454-9 [16461806.001]
  • [Cites] Arch Gynecol Obstet. 2007 Dec;276(6):649-53 [17549503.001]
  • [Cites] Pediatr Hematol Oncol. 2008 Jan-Feb;25(1):79-82 [18231958.001]
  • [Cites] Arch Surg. 2003 Sep;138(9):987-90 [12963656.001]
  • [Cites] Eur J Surg Oncol. 2001 Dec;27(8):723-30 [11735168.001]
  • [Cites] Cancer. 1996 Mar 1;77(5):910-6 [8608483.001]
  • [Cites] Plast Reconstr Surg. 2007 Jul;120(1):13e-19e [17572540.001]
  • (PMID = 20947486.001).
  • [ISSN] 1699-3055
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  •  go-up   go-down


98. Lien HC, Lu YS, Cheng AL, Chang WC, Jeng YM, Kuo YH, Huang CS, Chang KJ, Yao YT: Differential expression of glucocorticoid receptor in human breast tissues and related neoplasms. J Pathol; 2006 Jul;209(3):317-27
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential expression of glucocorticoid receptor in human breast tissues and related neoplasms.
  • Glucocorticoid receptor (GR) is a steroid hormone receptor that has been shown to play important roles in mammary development and differentiation, and has been implicated in breast tumourigenesis, but its precise biological significance in mammary pathophysiology remains unclear.
  • In order to generate a comprehensive expression profile for GR in normal versus neoplastic breast tissues, GR expression was investigated in situ in 400 human breast tissue samples, comprising normal tissue and a range of benign, pre-invasive, and invasive lesions, using immunohistochemical assays.
  • The novel expression of GR in myoepithelium, not observed in luminal epithelium, not only demonstrates expression patterns exclusive to the alpha form of oestrogen receptor and progesterone receptor and suggests distinctive functions between GR and these two important steroid hormone receptors in the breast, but may also indicate unique physiological and perhaps pathological roles for the myoepithelium in mediating the effects of glucocorticoid hormones in the breast.
  • The strong expression of GR in metaplastic carcinomas (94.4%) and malignant phyllodes tumours (92.3%) suggests a pathogenetic role for GR, and implies that targeting GR in these tumours may have potential therapeutic application.
  • This marked discrepancy warrants a re-examination of the biological roles of GR in the pathophysiology of breast malignancy.
  • The lack of methylation in the promoter region of the GR gene in all 118 non-metaplastic carcinomas, as demonstrated by methylation-specific PCR and bisulphite DNA sequencing analysis, indicates that methylation is less likely to play a role in the reduction of GR expression in non-metaplastic carcinoma of the breast.
  • [MeSH-major] Breast / metabolism. Breast Neoplasms / metabolism. Receptors, Glucocorticoid / metabolism
  • [MeSH-minor] Base Sequence. Carcinoma, Intraductal, Noninfiltrating / genetics. Carcinoma, Intraductal, Noninfiltrating / metabolism. Carcinoma, Lobular / genetics. Carcinoma, Lobular / metabolism. DNA Methylation. DNA, Neoplasm / genetics. Epithelial Cells / metabolism. Female. Gene Expression. Humans. Immunoenzyme Techniques. Molecular Sequence Data. Neoplasm Invasiveness. Phyllodes Tumor / genetics. Phyllodes Tumor / metabolism. Promoter Regions, Genetic / genetics

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright (c) 2006 Pathological Society of Great Britain and Ireland.
  • (PMID = 16639692.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Receptors, Glucocorticoid
  •  go-up   go-down


99. Tomimaru Y, Komoike Y, Egawa C, Motomura K, Inaji H, Kataoka TR, Koyama H: A case of phyllodes tumor of the breast with a lesion mimicking fibroadenoma. Breast Cancer; 2005;12(4):322-6
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of phyllodes tumor of the breast with a lesion mimicking fibroadenoma.
  • We report a case of phyllodes tumor (PT) with multiple lesions partly mimicking fibroadenoma (FA).
  • A 43-year-old woman was referred to our institute because of a left breast mass which was diagnosed as FA clinically.
  • On histological examination, the tumor consisted of three different components; a lesion diagnosed as FA, another lesion as benign PT, and the other lesion as borderline PT.
  • Finally, the tumor was diagnosed as borderline PT.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / diagnosis. Fibroadenoma / diagnosis. Phyllodes Tumor / diagnosis

  • Genetic Alliance. consumer health - Phyllodes Tumor.
  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16286914.001).
  • [ISSN] 1340-6868
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


100. Solberg OG, Blom GP, Stavem K: [A patient with pulmonary metastasis of phyllodes tumour of the breast]. Tidsskr Nor Laegeforen; 2005 Nov 3;125(21):2956-7
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A patient with pulmonary metastasis of phyllodes tumour of the breast].
  • BACKGROUND: Phyllodes tumours are rare neoplasms of the female breast.
  • Tumours range from the benign to the highly malignant.
  • Based on histological growth pattern, number of mitoses, pleomorphism and stroma characteristics, tumours are classified as malignant, borderline, or benign.
  • After surgical treatment of malignant phyllodes tumours, ten-year survival of 42% is reported.
  • MATERIAL AND METHODS: We present the case history of a 59-year-old woman with a pulmonary metastasis from a malignant phyllodes tumour of the breast.
  • Review of the specimen from a mastectomy 14 months earlier, for what was then considered a benign phyllodes tumour, confirmed a diagnosis of a primary malignant phyllodes tumour with pulmonary metastases.
  • INTERPRETATION: Diagnosis and treatment of phyllodes tumours require close cooperation between the radiologist, the pathologist and the clinician.
  • [MeSH-major] Breast Neoplasms / secondary. Lung Neoplasms / secondary. Phyllodes Tumor / secondary

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • MedlinePlus Health Information. consumer health - Lung Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] Tidsskr Nor Laegeforen. 2005 Nov 3;125(21):2958 [16299883.001]
  • (PMID = 16299881.001).
  • [ISSN] 0807-7096
  • [Journal-full-title] Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
  • [ISO-abbreviation] Tidsskr. Nor. Laegeforen.
  • [Language] nor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Norway
  •  go-up   go-down






Advertisement