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1. Fukuoka H, Moriuchi M, Yano H, Nagayasu T, Moriuchi H: No association of mouse mammary tumor virus-related retrovirus with Japanese cases of breast cancer. J Med Virol; 2008 Aug;80(8):1447-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] No association of mouse mammary tumor virus-related retrovirus with Japanese cases of breast cancer.
  • Mouse mammary tumor virus (MMTV) is the causative agent of breast tumors in mice.
  • To demonstrate if MMTV-related retrovirus is involved in Japanese cases of breast cancer, breast tissue specimens from 46 breast cancer patients and 3 patients with benign mammary tumors were investigated.
  • [MeSH-major] Breast Neoplasms. Gene Products, env / genetics. Genes, env. Mammary Tumor Virus, Mouse / isolation & purification
  • [MeSH-minor] Adenocarcinoma, Mucinous / epidemiology. Adenocarcinoma, Mucinous / genetics. Adenocarcinoma, Mucinous / virology. Adult. Aged. Aged, 80 and over. Animals. Blotting, Southern. Carcinoma, Ductal, Breast / epidemiology. Carcinoma, Ductal, Breast / genetics. Carcinoma, Ductal, Breast / virology. Carcinoma, Intraductal, Noninfiltrating / epidemiology. Carcinoma, Intraductal, Noninfiltrating / genetics. Carcinoma, Intraductal, Noninfiltrating / virology. Cell Line, Tumor. Female. Fibroadenoma / epidemiology. Fibroadenoma / genetics. Fibroadenoma / virology. Humans. Japan / epidemiology. Mice. Middle Aged. Nucleic Acid Hybridization. Phyllodes Tumor / epidemiology. Phyllodes Tumor / genetics. Phyllodes Tumor / virology. Polymerase Chain Reaction

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  • (PMID = 18551605.001).
  • [ISSN] 1096-9071
  • [Journal-full-title] Journal of medical virology
  • [ISO-abbreviation] J. Med. Virol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gene Products, env
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2. Bolívar AV, Alonso-Bartolomé P, García EO, Ayensa FG: Ultrasound-guided core needle biopsy of non-palpable breast lesions: a prospective analysis in 204 cases. Acta Radiol; 2005 Nov;46(7):690-5
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  • RESULTS: Among the 204 non-palpable breast lesions for which histopathological findings were obtained by US-guided core biopsy, 118 were malignant (114 carcinoma, 2 metastasis, 1 lymphoma, and 1 malignant phyllodes tumor) and 86 were benign (4 carcinoma and 82 benign lesions confirmed at surgery or after at least 2 years of follow-up).

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  • (PMID = 16372687.001).
  • [ISSN] 0284-1851
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
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3. Abdallah A, Saklaoui O, Stückle C, Sommerer F, Hatzmann W, Audretsch W, Wesemann A, Zink M, Skoljarev L, Papadopoulos S: [Case reports of operative management of very large, benign phylloid tumors--is a safety margin necessary?]. Gynakol Geburtshilfliche Rundsch; 2009;49(4):320-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Case reports of operative management of very large, benign phylloid tumors--is a safety margin necessary?].
  • The phylloid tumor (PT, formerly called cystosarcoma phylloides) is a rare neoplasia of the female breast.
  • In spite of progress in early diagnosis, PTs recur frequently--independently of tumor's degree of malignancy.
  • Especially in cases of malignant PT, complete resection with tumor-free margins is seen as the only predictive marker for tumor recurrence or metastases.
  • Benign PT is also often resected with wide tumor-free margins.
  • Because of the tumor's occasionally enormous dimensions, this therapy concept makes breast-conserving surgery almost impossible.
  • A simple enucleation of benign PT is an option to facilitate the preservation of breast tissue and a cosmetically satisfactory breast reconstruction.
  • In the case of particularly large benign PT, enucleation even without wide margins prevents tumor recurrence.
  • [MeSH-major] Breast Neoplasms / surgery. Mastectomy, Subcutaneous / methods. Phyllodes Tumor / surgery

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  • (PMID = 20530948.001).
  • [ISSN] 1423-0011
  • [Journal-full-title] Gynäkologisch-geburtshilfliche Rundschau
  • [ISO-abbreviation] Gynakol Geburtshilfliche Rundsch
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Switzerland
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4. Jones AM, Mitter R, Springall R, Graham T, Winter E, Gillett C, Hanby AM, Tomlinson IP, Sawyer EJ, Phyllodes Tumour Consortium: A comprehensive genetic profile of phyllodes tumours of the breast detects important mutations, intra-tumoral genetic heterogeneity and new genetic changes on recurrence. J Pathol; 2008 Apr;214(5):533-44
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  • [Title] A comprehensive genetic profile of phyllodes tumours of the breast detects important mutations, intra-tumoral genetic heterogeneity and new genetic changes on recurrence.
  • The aims of this study were to identify genetic changes associated with malignant progression of the fibroepithelial neoplasms, phyllodes tumours of the breast (PTs), and to ascertain whether genetic progression occurs when PTs recur locally.
  • A further aim was to assess whether the genetic data support the classification of these tumours into three subtypes, benign, borderline and malignant.
  • 126 PTs (37 benign, 41 borderline, 48 malignant) were analysed by either array-CGH or the Illumina Goldengate assay.
  • Cluster analysis of the array-CGH data supported the division of malignant and borderline PTs into two separate groups, one comprising almost all malignant lesions and the other, benign and borderline tumours.
  • Analysis of paired primary and recurrent tumours showed that recurrent tumours often acquired new genetic changes; in particular, benign tumours tended to acquire changes characteristic of the malignant/borderline phenotype.
  • [MeSH-major] Breast Neoplasms / genetics. Chromosome Aberrations. Neoplasm Recurrence, Local / genetics. Phyllodes Tumor / genetics
  • [MeSH-minor] Chromosomes, Human, Pair 9 / genetics. Cluster Analysis. DNA Methylation. DNA, Neoplasm / genetics. Disease Progression. Female. Gene Expression Profiling / methods. Genes, p16. Humans. Mutation. Nucleic Acid Hybridization / methods. RNA, Messenger / genetics

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  • [Copyright] Copyright (c) 2008 Pathological Society of Great Britain and Ireland
  • (PMID = 18288784.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / /
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / RNA, Messenger
  • [Investigator] Walker R; Pinder S; Jones L; Ellis I; Tan PH; Macartney J; Green D; Hales S; Harding-Mackean C; Colclough A; MacNeill F; Rowlands D; Smith C; Fentiman I; Cane P; Desai A; Goderya R; Nerurkar A; Kissin M; Jackson P
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5. Tea MK, Asseryanis E, Kroiss R, Kubista E, Wagner T: Surgical breast lesions in adolescent females. Pediatr Surg Int; 2009 Jan;25(1):73-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Breast diseases in teenage girls are fortunately uncommon, with most presenting masses being benign.
  • RESULTS: Thirty-seven female patients with an average age of 16 years (ranging 12-18 years) were operated on for breast tumor and/or discharge.
  • Both patients were diagnosed with a noninvasive ductal carcinoma in situ (DCIS) within a fibroadenoma at the age of 16.
  • As breast neoplasm was found in two cases, a malignancy rate of 4.7% was observed.
  • The most common histologies were fibroadenoma (n=27) and fibrocystic disease (n=4).
  • [MeSH-minor] Adolescent. Austria. Carcinoma in Situ / pathology. Carcinoma in Situ / surgery. Carcinoma, Ductal, Breast / pathology. Carcinoma, Ductal, Breast / surgery. Child. Female. Fibroadenoma / pathology. Fibroadenoma / surgery. Genetic Predisposition to Disease. Humans. Mastectomy. Phyllodes Tumor / pathology. Phyllodes Tumor / surgery. Retrospective Studies

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  • (PMID = 18985359.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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6. Kapila K, Pathan SK, Al-Mosawy FA, George SS, Haji BE, Al-Ayadhy B: Fine needle aspiration cytology of breast masses in children and adolescents: experience with 1404 aspirates. Acta Cytol; 2008 Nov-Dec;52(6):681-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: The morphologic spectrum seen in females was inflammatory lesions (4%), benign ductal cells (20%), ductal hyperplasia (0.6%), papillary lesions (0.7%), benign neoplasms (69%), suspicious cytology (0.3%) and cancer (0.3%).
  • Of the benign neoplasms, 98% (831 of 851) were fibroadenomas, with 12 cases of phyllodes (benign), 5 cases of lipoma and 3 cases of adenoma.
  • Only 3% of the male breast aspirates provided a diagnostic challenge, while 89% of them showed benign ductal cells.
  • The aspirates are mostly benign and can be managed conservatively.
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Carcinoma, Ductal, Breast / pathology. Carcinoma, Lobular / pathology. Child. Child, Preschool. Female. Humans. Hyperplasia / pathology. Immunoenzyme Techniques. Infant. Male. Young Adult

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  • (PMID = 19068671.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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7. Lv S, Niu Y, Wei L, Liu Q, Wang X, Chen Y: Chromosomal aberrations and genetic relations in benign, borderline and malignant phyllodes tumors of the breast: a comparative genomic hybridization study. Breast Cancer Res Treat; 2008 Dec;112(3):411-8
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  • [Title] Chromosomal aberrations and genetic relations in benign, borderline and malignant phyllodes tumors of the breast: a comparative genomic hybridization study.
  • Phyllodes tumors are not quite rare fibroepithelial neoplasms of the breast that show a broad spectrum of clinical behaviour.
  • We have used comparative genomic hybridization to analyze chromosomal copy number changes in 36 cases of phyllodes tumors (including benign, borderline and malignant phyllodes tumors, 12 cases each).
  • The average number of chromosome copy changes (range) in benign, borderline and malignant phyllodes tumors were 5.58 (0-20), 14.08 (3-23), and 12.42 (0-29) respectively.
  • In benign phyllodes tumors the number of gains and losses was in balance (2.50 vs 3.08), while in borderline and malignant phyllodes tumors gains occurred more often than losses (9.25 vs 4.83, 9.5 vs 2.92).
  • The result suggests the molecular cytogenetics of borderline and malignant phyllodes tumors is similar, and the most striking difference with benign phyllodes tumors is an increased number of chromosomal gains in a nonrandom distribution.
  • Gains of 4q12 seem especially to be involved in the progression of benign to borderline and malignant phyllodes tumors, possibly because of overexpression of oncogenes at these loci.
  • [MeSH-major] Breast Neoplasms / genetics. Chromosome Aberrations. Nucleic Acid Hybridization. Phyllodes Tumor / genetics

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  • (PMID = 18189161.001).
  • [ISSN] 1573-7217
  • [Journal-full-title] Breast cancer research and treatment
  • [ISO-abbreviation] Breast Cancer Res. Treat.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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8. El Hag IA, Aodah A, Kollur SM, Attallah A, Mohamed AA, Al-Hussaini H: Cytological clues in the distinction between phyllodes tumor and fibroadenoma. Cancer Cytopathol; 2010 Feb 25;118(1):33-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytological clues in the distinction between phyllodes tumor and fibroadenoma.
  • BACKGROUND: Fine-needle aspiration (FNA) sensitivity in discriminating between phyllodes tumor and its benign mimicker fibroadenoma (FA) remains low.
  • Because a preoperative categorization of phyllodes tumor is crucial for their appropriate management, the authors undertook this study in an effort to improve the outcome of FNA by identifying reliable distinguishing features.
  • METHODS: FNA smears from 15 and 12 histologically proven cases of phyllodes tumor and FA, respectively, were reviewed.
  • A group of cytological features that may distinguish between phyllodes tumor and FA were identified.
  • Their value and reproducibility in categorizing phyllodes tumor cases were tested.
  • RESULTS: Three major cytological features were exclusively seen in all of, or the vast majority of, the phyllodes tumor cases; fibromyxoid stromal fragments with spindle nuclei (90%), fibroblastic pavements (93%), and appreciable number of spindles cells of fibroblastic nature among dispersed cell population (100%).
  • The identification of these features improved the pick-up rate of phyllodes tumor from 40% to 100% and had substantial (kappa = 0.56-0.73) interobserver and almost perfect (kappa = 0.83) intraobserver reproducibility.
  • There was no significant difference in the epithelial component characteristics between phyllodes tumor and FA.
  • The frequency and degree of atypia in the dispersed cell population correlated well to the histological grade of phyllodes tumor.
  • CONCLUSIONS: FNA has proven to be a reliable test in differentiating between phyllodes tumor and FA with high sensitivity and good reproducibility.
  • [MeSH-major] Breast Neoplasms / diagnosis. Fibroadenoma / diagnosis. Phyllodes Tumor / diagnosis

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  • [Copyright] (c) 2010 American Cancer Society.
  • (PMID = 20094997.001).
  • [ISSN] 1934-662X
  • [Journal-full-title] Cancer cytopathology
  • [ISO-abbreviation] Cancer Cytopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Taira N, Takabatake D, Aogi K, Ohsumi S, Takashima S, Nishimura R, Teramoto N: Phyllodes tumor of the breast: stromal overgrowth and histological classification are useful prognosis-predictive factors for local recurrence in patients with a positive surgical margin. Jpn J Clin Oncol; 2007 Oct;37(10):730-6
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  • [Title] Phyllodes tumor of the breast: stromal overgrowth and histological classification are useful prognosis-predictive factors for local recurrence in patients with a positive surgical margin.
  • BACKGROUND: The local recurrence rate of phyllodes tumors is high and ensuring a sufficient surgical margin is considered important for local control.
  • However, the preoperative diagnosis rate of phyllodes tumors is low and we often encounter cases in which a sufficient surgical margin is not achieved, since in routine medical practice the lesion may not be diagnosed as phyllodes tumor until postoperative biopsy of a mammary mass.
  • Furthermore, there are no established therapeutic guidelines for surgical stump-positive phyllodes tumors.
  • We reviewed the outcomes of excision of phyllodes tumors to investigate factors involved in local recurrence and to determine the indication for re-excision in stump-positive cases.
  • METHODS: The subjects were 45 patients treated for phyllodes tumors at our institution from January 1980 to July 2005.
  • Age, tumor size, surgical method, stromal cellular atypia, mitotic activity, stromal overgrowth, histological classification and surgical stump status were analyzed.
  • RESULTS: Median age was 45 years old (range 28-75) and tumor size was 1-17 cm (median 3.5 cm).
  • Pathologic diagnoses were benign, borderline and malignant in 31, five and nine cases, respectively, and the surgical stump was negative in 27 lesions and positive in 15.
  • CONCLUSION: Wide excision is the preferred therapy for phyllodes tumor and preoperative diagnosis is important for good local control.
  • [MeSH-major] Breast Neoplasms / pathology. Breast Neoplasms / surgery. Neoplasm Recurrence, Local / prevention & control. Phyllodes Tumor / pathology. Phyllodes Tumor / surgery

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  • (PMID = 17932112.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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10. Kang Y, Kim JH, Lee TH, Kim TS, Jung WH, Chung HC, Park BW, Sheen SS, Han JH: Expression of anaphase-promoting complex7 in fibroadenomas and phyllodes tumors of breast. Hum Pathol; 2009 Jan;40(1):98-107
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of anaphase-promoting complex7 in fibroadenomas and phyllodes tumors of breast.
  • The average values of the anaphase-promoting complex7 and Ki-67 labeling indices increased in order from benign to malignant within the phyllodes tumor group, and the fibroadenoma and juvenile fibroadenoma exhibited lower levels of anaphase-promoting complex7 and Ki-67 expression than did the phyllodes tumor.
  • The frequency of anaphase-promoting complex7-positive stromal cells correlated with Ki-67 expression in phyllodes tumor and in all of the examined breast tumors.
  • In addition, phyllodes tumor can be differentiated from juvenile fibroadenoma with increased mitotic figures mimicking phyllodes tumor by anaphase-promoting complex7 and Ki-67 immunochemistry.
  • Because anaphase-promoting complex7 is expressed at higher levels than is Ki-67, it may overcome the limitations of the Ki-67 labeling index with regard to the differentiation of benign phyllodes tumor from fibroadenoma.
  • [MeSH-major] Breast Neoplasms / metabolism. Fibroadenoma / metabolism. Gene Expression Regulation, Neoplastic. Phyllodes Tumor / metabolism. Ubiquitin-Protein Ligase Complexes / metabolism

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  • (PMID = 18789487.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; EC 6.3.2.19 / Anaphase-Promoting Complex-Cyclosome; EC 6.3.2.19 / Ubiquitin-Protein Ligase Complexes
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11. Lenhard MS, Kahlert S, Himsl I, Ditsch N, Untch M, Bauerfeind I: Phyllodes tumour of the breast: clinical follow-up of 33 cases of this rare disease. Eur J Obstet Gynecol Reprod Biol; 2008 Jun;138(2):217-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phyllodes tumour of the breast: clinical follow-up of 33 cases of this rare disease.
  • OBJECTIVE: The "cystosarcoma phyllodes" of the breast is a rare entity which accounts for 0.5% of all breast neoplasms.
  • STUDY DESIGN: The data of 5270 patients with primary breast neoplasms treated in our department between 1984 and 2005 were retrospectively analysed for the histopathologic diagnosis of a cystosarcoma phyllodes.
  • The clinical data was analysed with respect to tumour grading and size, treatment and prognosis.
  • In the histopathological analysis, tumour grade was classified as benign in 40%, borderline in 27% and malignant in 33% of patients.
  • Mean tumour size was 6.9 cm, and no lymph node infiltration was found in the 10 patients who received axillary lymph node dissection.
  • The local recurrence rate was 50% in malignant, 20% in borderline and only 8% in benign tumours.
  • Distant metastases were seen in three patients (9%) with malignant phyllodes tumours.
  • Neither regarding age at primary diagnosis nor in tumour size there was a significant difference between patients with local recurrence or metastatic spread and those without (p=0.284 tumour size; p=0.739 for age; Mann-Whitney U-test).
  • [MeSH-major] Breast Neoplasms / pathology. Phyllodes Tumor / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Middle Aged. Neoplasm Recurrence, Local. Rare Diseases. Retrospective Studies

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  • (PMID = 17868973.001).
  • [ISSN] 0301-2115
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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12. Bellolio J E, Guzmán G P, Orellana C J, Roa S JC, Villaseca H M, Araya O JC, Tapia E O, Ineda N V: [Diagnostic value of frozen section biopsy during surgery for breast lesions or neoplasms]. Rev Med Chil; 2009 Sep;137(9):1173-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: During the surgical treatment of breast neoplasms (benign or malignant), frozen section biopsy is frequently requested to assess the kind of lesion and determine the surgical margins.
  • The diagnosis of phyllodes tumor was missed by frozen section biopsy in three cases.

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  • (PMID = 20011957.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Chile
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13. Abdelkrim SB, Trabelsi A, Bouzrara M, Boudagga MZ, Memmi A, Bakir DA, Mokni M: Phyllodes Tumors of the Breast: A Review of 26 Cases. World J Oncol; 2010 Jun;1(3):129-134
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phyllodes Tumors of the Breast: A Review of 26 Cases.
  • Background: Phyllodes tumors of the breast are rare and locally aggressive neoplasms.
  • Methods: The authors analyzed retrospectively clinical, radiological, histopathological and therapeutic features as well as outcome in a series of 26 cases diagnosed as phyllodes tumors of the breast at the Pathology Department of Farhat Hached Hospital, Sousse, Tunisia, from 2003 to 2009.
  • The slides were reviewed in order to classify the tumors into benign, borderline and malignant on the basis of the criteria proposed by the World Health Organization.
  • The analysis of this series showed the following characteristics: mean age at diagnosis was 40 years (19 - 66), tumor size was 1.5 - 40 cm (mean: 7.8 cm); the chief complaint was a mammary mass; the right breast was affected in 14 cases, the upper outer quadrant was the most commonly involved site (42.3%); surgical treatment was used in all cases, 21 patients (80.8%) were treated conservatively (13 benign, 6 borderline, and 2 malignant) and 5 (19.2%) by radical surgery (1 borderline and 4 malignant); seven patients underwent post-operative radiotherapy; in 14/19 cases (73.7%), a good correlation was observed between intraoperative frozen section analysis and definitive histology; the tumor was classed as benign in 13 cases (50%), borderline in 7 cases (27%) and malignant in 6 cases (23%); follow-up data was available in 22 cases; the rate of recurrence was 23% (1 benign, 3 borderline, and 2 malignant) after a mean follow-up of 13.6 months; all the recurrent tumors were initially treated by lumpectomy and were close to margin at the initial pathologic examination; the treatment of recurrences consisted of simple mastectomy in 5 cases, and local excision in one case; three patients developed metastases, one of whom after recurrence<b>;</b> three patients have died.
  • Conclusions: This is a substantial single institution experience of a rare tumor.
  • Phyllodes tumors of the breast have an unpredictable outcome, thus a wide local excision, with an adequate margin of normal breast tissue, is the preferred initial therapy.

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  • (PMID = 29147192.001).
  • [ISSN] 1920-454X
  • [Journal-full-title] World journal of oncology
  • [ISO-abbreviation] World J Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Keywords] NOTNLM ; Outcome / Pathology / Phyllodes tumor / Prognosis / Treatment
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14. Resetkova E, Khazai L, Albarracin CT, Arribas E: Clinical and radiologic data and core needle biopsy findings should dictate management of cellular fibroepithelial tumors of the breast. Breast J; 2010 Nov-Dec;16(6):573-80
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  • Fibroepithelial lesions with cellular stroma identified on core needle biopsy (CNB) may prove to be either fibroadenoma or phyllodes tumor at excision; therefore, management of these rare lesions is highly controversial.
  • Cellular fibroepithelial lesions with indeterminate or suspect imaging findings, with larger size, and with an equivocal comment such as "cannot rule out phyllodes tumor" in the pathology report were excised more frequently (p = 0.05, p = 0.034, and p = 0.01, respectively).
  • Of 43 excised lesions, 13 were classified as benign phyllodes tumors, 23 as fibroadenoma and seven as benign cellular fibroepithelial lesion.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / pathology. Fibroadenoma / pathology. Mammography. Phyllodes Tumor / pathology

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  • [Copyright] © 2010 Wiley Periodicals, Inc.
  • (PMID = 21070433.001).
  • [ISSN] 1524-4741
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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15. Chen ZW, Saad RS: Ovarian adenosarcoma arising from benign cystadenoma and associated intraoperative consultation pitfalls. Int J Gynecol Pathol; 2010 Sep;29(5):415-8
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  • [Title] Ovarian adenosarcoma arising from benign cystadenoma and associated intraoperative consultation pitfalls.
  • The malignant component was underdiagnosed during frozen section examination as benign cystadenoma because of the deceptively benign gross appearance of the tumor.
  • On the permanent sections, a phyllodes-like pattern of stromal proliferation and periglandular condensation of atypical stromal cells with a mitotic count of 3 per 10 high-power fields was more apparent and led to the diagnosis of adenosarcoma.
  • The malignant component could not be distinguished from the benign component using immunohistochemical analysis.
  • To our knowledge, this is the first reported case of an adenosarcoma arising from a grossly benign cystadenoma and the third case in the literature of an adenosarcoma associated with a cystadeno(fibro)ma.
  • This case also shows the challenges in differentiating adenosarcoma from a benign counterpart on both frozen and permanent sections.

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  • (PMID = 20736764.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Sebag P, Tourasse C, Rouyer N, Lebas P, Dénier JF, Michenet P: [Value of vacuum assisted biopsies under sonography guidance: results from a multicentric study of 650 lesions]. J Radiol; 2006 Jan;87(1):29-34
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  • Lesions were categorized, using the classification from Stavros, between "probably benign", "indeterminate", "probably malignant" and "malignant" Histology was validated only after review of the clinical and radiological data, as well as surgical data when available.
  • All benign cases were included in an on-going follow-up protocol.
  • RESULTS: We have identified 471 benign lesions and 179 malignant lesions.
  • Three cancers were diagnosed in the cases of "probably benign lesions" and in the cases of "probably malignant lesions" 18 (27%) were inflammatory disorders.
  • Specificity is excellent with no cancer detected so far among the patients with benign findings, under follow-up.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Breast Neoplasms / pathology. Breast Neoplasms / ultrasonography. Carcinoma in Situ / pathology. Carcinoma, Ductal, Breast / pathology. Diagnosis, Differential. Female. Fibroadenoma / pathology. Follow-Up Studies. Humans. Hyperplasia. Middle Aged. Minimally Invasive Surgical Procedures. Papilloma / pathology. Phyllodes Tumor / pathology. Retrospective Studies. Sensitivity and Specificity. Vacuum

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  • (PMID = 16415777.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Multicenter Study
  • [Publication-country] France
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17. Cîmpean AM, Raica M, Nariţa D: Diagnostic significance of the immunoexpression of CD34 and smooth muscle cell actin in benign and malignant tumors of the breast. Rom J Morphol Embryol; 2005;46(2):123-9
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  • [Title] Diagnostic significance of the immunoexpression of CD34 and smooth muscle cell actin in benign and malignant tumors of the breast.
  • PURPOSE: Our aim was to investigate the distribution of CD34 and smooth muscle cell actin positive myofibroblasts in the stroma of the normal mammary gland, benign and malignant tumors.
  • RESULTS: We have found normal breast tissue, sclerosing adenosis, fibroadenomas, fibrocystic diseases, phyllodes tumor, DCIS, ductal invasive, lobular, squamous, medullary, mucinous, and papillary carcinomas.
  • All the normal breast tissues and most of benign lesions were positive for CD34 and negative for SMA.
  • The exceptions were represented by a case of fibroadenoma and the phyllodes tumor, with CD34 positivity and a focal acquisition of SMA; fibrocystic disease with associated apocrine metaplasia adjacent to a squamous carcinoma with loss of CD34 expression and focal acquisition of SMA.
  • CONCLUSIONS: Although there were some exceptions especially when one of the two markers was interpreted separately and in some cases associated with sclerotic stroma, we conclude that the combined expression of CD34 and a-SMA is of potential diagnostic value in the distinction between benign and malignant tumors in some difficult cases.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, CD / analysis. Biopsy. Carcinoma, Ductal / pathology. Female. Fibrocystic Breast Disease / pathology. Humans. Middle Aged. Neoplasm Invasiveness. Smad Proteins / analysis

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  • (PMID = 16286998.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD; 0 / Antigens, CD34; 0 / Smad Proteins
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18. Büchler T, Vorzilková E, Koukolík F, Melínova H, Abrahámová J: [Malignant subtype of cystosarcoma phyllodes with brain metastases]. Klin Onkol; 2010;23(6):446-8
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  • [Title] [Malignant subtype of cystosarcoma phyllodes with brain metastases].
  • [Transliterated title] Maligní forma cystosarcoma phyllodes s metastázami do mozku.
  • Cystosarcoma phyllodes is an uncommon type of breast tumour.
  • Benign, borderline, and malignant subtypes have been described.
  • Central nervous system metastases of the malignant subtype of cystosarcoma phyllodes are rare and associated with poor prognosis.
  • We report on a patient with malignant cystosarcoma phyllodes who developed metastatic disease six years after resection of the primary breast tumour.
  • Because metastatic malignant cystosarcoma phyllodes are largely resistant to treatment, the most important objective is to provide optimal management of the primary tumour before dissemination occurs.
  • [MeSH-major] Brain Neoplasms / secondary. Breast Neoplasms / pathology. Phyllodes Tumor / secondary

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  • (PMID = 21351423.001).
  • [ISSN] 0862-495X
  • [Journal-full-title] Klinická onkologie : casopis Ceské a Slovenské onkologické spolecnosti
  • [ISO-abbreviation] Klin Onkol
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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19. Tse GM, Niu Y, Shi HJ: Phyllodes tumor of the breast: an update. Breast Cancer; 2010;17(1):29-34
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  • [Title] Phyllodes tumor of the breast: an update.
  • Phyllodes tumor is an uncommon biphasic breast tumor, with the ability to recur and metastasize, and it behaves biologically like a stromal neoplasm.
  • Traditionally, phyllodes tumors are graded by the use of a set of histologic data into benign, borderline, and malignant.
  • In most series, all phyllodes tumors may recur, but only the borderline and malignant phyllodes tumors metastasize.
  • The expression of many biological markers, including p53, hormone receptors, proliferation markers, angiogenesis group of markers, c-kit, CD10 and epidermal growth factor receptor have been explored, and many have been shown to be variably expressed, depending on the grade of the tumor.
  • These markers are, however, of limited value in predicting the behavior of the tumor.
  • Recently investigators have reported a plethora of genetic changes in phyllodes tumors, the most consistent of which seems to be 1q gain by comparative genomic hybridization.
  • It is foreseeable that more exciting data will be generated to help us to understand the etiology and pathogenesis of phyllodes tumor.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Breast Neoplasms / pathology. Phyllodes Tumor / pathology
  • [MeSH-minor] Female. Humans. Neoplasm Staging. Prognosis


20. Jacobs TW, Chen YY, Guinee DG Jr, Holden JA, Cha I, Bauermeister DE, Hashimoto B, Wolverton D, Hartzog G: Fibroepithelial lesions with cellular stroma on breast core needle biopsy: are there predictors of outcome on surgical excision? Am J Clin Pathol; 2005 Sep;124(3):342-54
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  • Fibroepithelial lesions with cellular stroma (FELCS) in breast core needle biopsy (CNB) specimens may result in either fibroadenoma or phyllodes tumor at excision.
  • On excision, 16 patients had fibroadenomas and 12 had phyllodes tumors.
  • All CNB specimens with mildly increased stromal cellularity were fibroadenomas on excision (n=4), and all with markedly cellular stroma were phyllodes tumors (n=4).
  • Among CNB specimens with moderate cellularity (12 fibroadenomas and 8 phyllodes tumors), only stromal mitoses were discriminatory histologically.
  • Stromal proliferation indices were significantly higher in CNB that were phyllodes tumors vs fibroadenomas.
  • Assessment of stromal cellularity, mitoses, and proliferation indices might help determine the probability of phyllodes tumor occurring and guide management of these cases.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / pathology. Fibroadenoma / pathology. Phyllodes Tumor / pathology

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  • (PMID = 16191502.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Franceschini G, D'Ugo D, Masetti R, Palumbo F, D'Alba PF, Mulè A, Costantini M, Belli P, Picciocchi A: Surgical treatment and MRI in phyllodes tumors of the breast: our experience and review of the literature. Ann Ital Chir; 2005 Mar-Apr;76(2):127-40
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  • [Title] Surgical treatment and MRI in phyllodes tumors of the breast: our experience and review of the literature.
  • AIMS: To reassess the relationship between magnetic resonance imaging (MRI) findings and surgical resection margins in an attempt to address the issue of appropriate surgical management of phyllodes tumors (PT).
  • METHODS: Three female patients with a large palpable mass suspicious for phyllodes tumors were studied by mammography (MX), ultrasound (US) and dynamic MRI and then underwent surgery.
  • Pathological results showed 1 case of benign phylloides tumor, 1 case of borderline phylloides tumor and 1 case of malignant phylloides tumor.
  • CONCLUSIONS: MRI enabled complete visualization of the tumor even in the region close to the chest wall, as well as clear delineation from healthy glandular tissue and may help to define the appropriate surgical management of phylloides tumor.
  • [MeSH-major] Breast Neoplasms / diagnosis. Breast Neoplasms / surgery. Magnetic Resonance Imaging. Phyllodes Tumor / diagnosis. Phyllodes Tumor / surgery

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  • (PMID = 16302651.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Italy
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22. Kohli K, Jain D: Benign phylloides tumour with leiomyoma breast: a rare occurrence. ANZ J Surg; 2009 Jun;79(6):499-500
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  • [Title] Benign phylloides tumour with leiomyoma breast: a rare occurrence.
  • [MeSH-major] Breast Neoplasms / pathology. Leiomyoma / pathology. Neoplasms, Multiple Primary / pathology. Phyllodes Tumor / pathology

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  • (PMID = 19566888.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] Australia
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23. Pătraşcu A, Popescu CF, Pleşea IE, Bădulescu A, Tănase F, Mateescu G: Clinical and cytopathological aspects in phyllodes tumors of the breast. Rom J Morphol Embryol; 2009;50(4):605-11
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  • [Title] Clinical and cytopathological aspects in phyllodes tumors of the breast.
  • The frequency of mesenchymal breast tumors is very low, being represented mostly by tumors with biphasic proliferation (phyllodes tumors) and less by other types of non-epithelial tumors.
  • From clinical point of view, phyllodes tumors (PT) can mimic a breast carcinoma.
  • In current study, we assessed clinical aspects of 79 phyllodes tumors regarding patient's age and localization of the tumors.
  • The median age of the patients was 46.07-year-old, being progressively higher with grade of the tumors with significant values between benign and borderline tumors (p=0.04954) and between benign and malignant ones (p=0.02890).
  • The preoperative differentiation between a breast phyllodes tumor and a breast carcinoma is extremely important for avoiding of a useless radical surgery for the patient.
  • [MeSH-major] Breast Neoplasms / pathology. Phyllodes Tumor / pathology

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  • (PMID = 19942954.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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24. Dubb M, Michelow P, Grayson W: Cytologic features of trichoblastoma in fine needle aspiration biopsies. Acta Cytol; 2009 Nov-Dec;53(6):679-82
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  • On fine needle aspiration, the patient was diagnosed as having a benign skin adnexal tumor.
  • RESULTS: The cytologic features of trichoblastoma resembled a cellular fibroadenoma/phyllodes tumor on aspiration, not previously described in the literature.
  • If the cytomorphology of a skin or subcutaneous aspirate appears to resemble that of a fibroadenoma, the diagnosis of a trichoblastoma should be entertained.
  • If the tumor occurs in the region of the breast, distinction from a fibroadenoma would be difficult if these additional features were not prominent.
  • CONCLUSION: Knowledge of the cytologic features of trichoblastoma will allow correct management of the patient and prevent misdiagnosis as other benign or malignant tumors.

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  • (PMID = 20014558.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Basu S, Saxena V, Sharma CL, Kumar M: Image of the month. Phyllodes tumor (benign). Arch Surg; 2008 Feb;143(2):207-8
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  • [Title] Image of the month. Phyllodes tumor (benign).
  • [MeSH-major] Breast Neoplasms / pathology. Magnetic Resonance Imaging. Phyllodes Tumor / pathology. Pregnancy Complications, Neoplastic / pathology


26. Pawlicki J, Król R, Kajor M, Ziaja J: [Case of malignant tumour phyllodes converting to fibrosarcoma]. Pol Merkur Lekarski; 2007 Mar;22(129):215-7
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  • [Title] [Case of malignant tumour phyllodes converting to fibrosarcoma].
  • Tumour phyllodes is rare breast neoplasm.
  • Tumours phyllodes are composed of hypercellular mesenchymal stroma and epithelial elements.
  • They are commonly classified as benign, rarely as borderline or malignant.
  • There is a case of large (28 x 24 cm) malignant tumour phyllodes presented in the article.
  • In spite of unfavorable prognostic features of the tumour (large size, malignant histological character) and recurrences, final therapeutic effect was good.
  • [MeSH-major] Breast Neoplasms / pathology. Cell Transformation, Neoplastic / pathology. Fibrosarcoma / pathology. Neoplasm Recurrence, Local / pathology. Phyllodes Tumor / pathology

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  • (PMID = 17682679.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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27. Kuijper A, de Vos RA, Lagendijk JH, van der Wall E, van Diest PJ: Progressive deregulation of the cell cycle with higher tumor grade in the stroma of breast phyllodes tumors. Am J Clin Pathol; 2005 May;123(5):690-8
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  • [Title] Progressive deregulation of the cell cycle with higher tumor grade in the stroma of breast phyllodes tumors.
  • We studied cell cycle-regulating proteins in phyllodes tumor pathogenesis by immunohistochemical analysis for Ki-67, cyclin A, cyclin D1, retinoblastoma protein (pRb), p53, p16INK4A, bcl-2, and p21waf1 in the epithelium and stroma of 40 primary (benign, 21; borderline, 8; malignant, 11) and 7 recurrent tumors of different grades.
  • Stromal overexpression of p16INK4A, p53, cyclin A, pRb, and p21waf1 correlated significantly with tumor grade.
  • Stromal cyclin A expression was the best separating marker between tumor grades.
  • The stromal component of mammary phyllodes tumors displays an increasing level of cell cycle deregulation with higher tumor grade; the epithelial compartment mostly remains inconspicuous.
  • Several combinations of aberrantly expressed cell cycle proteins seem important in the stromal progression of phyllodes tumors.
  • [MeSH-major] Breast Neoplasms / pathology. Cell Cycle. Cell Cycle Proteins / metabolism. Phyllodes Tumor / pathology. Stromal Cells / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Female. Humans. Immunoenzyme Techniques. Middle Aged. Neoplasm Proteins / metabolism. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Prognosis


28. Kuo YJ, Ho DM, Tsai YF, Hsu CY: Invasive ductal carcinoma arising in phyllodes tumor with isolated tumor cells in sentinel lymph node. J Chin Med Assoc; 2010 Nov;73(11):602-4
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  • [Title] Invasive ductal carcinoma arising in phyllodes tumor with isolated tumor cells in sentinel lymph node.
  • Phyllodes tumor (PT) consists of stroma of variable grading and benign ductal epithelium.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / pathology. Lymph Nodes / pathology. Phyllodes Tumor / pathology. Sentinel Lymph Node Biopsy
  • [MeSH-minor] Adult. Female. Humans. Neoplasm Invasiveness

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  • [Copyright] Copyright © 2010 Elsevier. Published by Elsevier B.V. All rights reserved.
  • (PMID = 21093830.001).
  • [ISSN] 1728-7731
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China (Republic : 1949- )
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29. Chen SJ, Cheng KS, Dai YC, Sun YN, Chen YT, Chang KY, Yu SN, Chang TW, Tsai HM, Hsien CC: Quantitatively characterizing the textural features of sonographic images for breast cancer with histopathologic correlation. J Ultrasound Med; 2005 May;24(5):651-61
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  • A statistical feature matrix was applied to quantify the texture difference (ie, the dissimilarity) of the sonographic images for malignant and benign breast tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy, Fine-Needle. Carcinoma, Ductal, Breast / pathology. Carcinoma, Ductal, Breast / surgery. Carcinoma, Ductal, Breast / ultrasonography. Carcinoma, Intraductal, Noninfiltrating / pathology. Carcinoma, Intraductal, Noninfiltrating / surgery. Carcinoma, Intraductal, Noninfiltrating / ultrasonography. Confidence Intervals. Diagnosis, Differential. Female. Fibroadenoma / pathology. Fibroadenoma / surgery. Fibroadenoma / ultrasonography. Humans. Mastectomy / methods. Middle Aged. Phyllodes Tumor / pathology. Phyllodes Tumor / surgery. Phyllodes Tumor / ultrasonography

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  • (PMID = 15840797.001).
  • [ISSN] 0278-4297
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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30. Morgan JM, Douglas-Jones AG, Gupta SK: Analysis of histological features in needle core biopsy of breast useful in preoperative distinction between fibroadenoma and phyllodes tumour. Histopathology; 2010 Mar;56(4):489-500
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  • [Title] Analysis of histological features in needle core biopsy of breast useful in preoperative distinction between fibroadenoma and phyllodes tumour.
  • Despite the greater yield of material with spatial information, the distinction between fibroepithelial lesions of the breast, fibroadenoma (FA) and benign phyllodes tumour (PT), remains problematic.
  • [MeSH-major] Biopsy, Needle / methods. Breast Neoplasms / pathology. Fibroadenoma / pathology. Phyllodes Tumor / pathology

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  • (PMID = 20459556.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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31. Santosh KV, Sumana BS: Benign intracystic phyllodes tumor of breast. Indian J Pathol Microbiol; 2010 Apr-Jun;53(2):385-6
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  • [Title] Benign intracystic phyllodes tumor of breast.
  • [MeSH-major] Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Phyllodes Tumor / diagnosis. Phyllodes Tumor / pathology

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  • (PMID = 20551574.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] India
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32. Wurdinger S, Herzog AB, Fischer DR, Marx C, Raabe G, Schneider A, Kaiser WA: Differentiation of phyllodes breast tumors from fibroadenomas on MRI. AJR Am J Roentgenol; 2005 Nov;185(5):1317-21
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  • [Title] Differentiation of phyllodes breast tumors from fibroadenomas on MRI.
  • OBJECTIVE: The purpose of our study was to evaluate the MRI appearance of phyllodes breast tumors and to differentiate them from fibroadenomas.
  • MR images of 23 patients with 24 phyllodes breast tumors (one malignant, 23 benign) were analyzed with respect to morphology and contrast enhancement.
  • RESULTS: Well-defined margins were seen in 87.5% of the phyllodes tumors and 70.4% of the fibroadenomas, and a round or lobulated shape in 100% and 90.1%, respectively.
  • A heterogeneous internal structure was observed in 70.8% of phyllodes tumors and in 49.4% of fibroadenomas.
  • Nonenhancing internal septations were found in 45.8% of phyllodes tumors and 27.2% of fibroadenomas.
  • A significantly greater increase in signal was seen on T2-weighted images in the tissue surrounding phyllodes tumors (21%) compared with fibroadenomas (1.2%).
  • After the administration of contrast material, 33.3% of phyllodes tumors and 22.2% of fibroadenomas showed a suspicious signal intensity-time course.
  • CONCLUSION: Phyllodes breast tumors and other fibroadenomas cannot be precisely differentiated on breast MRI.
  • Phyllodes tumors have benign morphologic features and contrast enhancement characteristics suggestive of malignancy in 33% of cases.
  • [MeSH-major] Breast Neoplasms / diagnosis. Fibroadenoma / diagnosis. Magnetic Resonance Imaging. Phyllodes Tumor / diagnosis

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  • (PMID = 16247156.001).
  • [ISSN] 0361-803X
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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33. Ezeome ER, Okafor OC, Nwajiobi CE, Osuagwu CC: Bilateral benign phyllodes tumour in a nulliparous woman: a case report and review of literature. Niger J Clin Pract; 2007 Mar;10(1):66-9
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  • [Title] Bilateral benign phyllodes tumour in a nulliparous woman: a case report and review of literature.
  • Cystosarcoma Phyllodes is an uncommon disease of the breast with variable clinical behaviour.
  • In this communication, we present a case of metachronous bilateral benign cystosarcoma phyllodes presenting in a 24year old nulliparous lady.
  • This case unlike most reported cases of bilateral Phyllodes tumour occurred in a nulliparous lady.
  • [MeSH-major] Breast Neoplasms / diagnosis. Phyllodes Tumor / diagnosis

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  • (PMID = 17668718.001).
  • [ISSN] 1119-3077
  • [Journal-full-title] Nigerian journal of clinical practice
  • [ISO-abbreviation] Niger J Clin Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nigeria
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34. Taira N, Aogi K, Ohsumi S, Takashima S, Kawamura S, Nishimura R: Epidermal inclusion cyst of the breast. Breast Cancer; 2007;14(4):434-7
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  • Mammography revealed a round and smoothly outlined mass, which indicated a benign tumor, and sonography showed an irregularly shaped and heterogeneous hypoechoic mass.
  • A phyllodes tumor or a giant fibroadenoma was suspected on the basis of clinical and imaging findings, but the resected specimen revealed an epidermal inclusion cyst.

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  • (PMID = 17986812.001).
  • [ISSN] 1880-4233
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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35. Biondi A, Di Giuntao M, Motta S, Privitera G, Fichera DS, Ciuni R, Basile F: [Benign phylloides tumor of the breast. Considerations on a clinical case]. Ann Ital Chir; 2009 Nov-Dec;80(6):471-4
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  • [Title] [Benign phylloides tumor of the breast. Considerations on a clinical case].
  • [Transliterated title] Tumore fillode gigante benigno della mammella. Considerazioni a proposito di un caso clinico.
  • Phyllodes tumors are unusual biphasic fibroepithelial neoplasms of the breast, accounting for < 1% of all breast tumors and raising issues of diagnosis and therapeutic choice.
  • We talk about giant phyllodes tumors.
  • Conservative treatment can be effective also in giant tumors depending upon the size of the tumor and the breast if a complete excision with an adequate margin of normal breast tissue can be achieved, so avoiding local recurrence often accompanied by worse histopathology.
  • The Authors report the case of a giant benign phyllode tumor of the breast treated with conservative surgery, quadrantectomy and oncoplasty.
  • [MeSH-major] Breast Neoplasms. Phyllodes Tumor

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  • (PMID = 20476682.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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36. Sotheran W, Domjan J, Jeffrey M, Wise MH, Perry PM: Phyllodes tumours of the breast--a retrospective study from 1982-2000 of 50 cases in Portsmouth. Ann R Coll Surg Engl; 2005 Sep;87(5):339-44
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  • [Title] Phyllodes tumours of the breast--a retrospective study from 1982-2000 of 50 cases in Portsmouth.
  • INTRODUCTION: This study is a retrospective analysis of 50 phyllodes tumours to determine the optimal surgical procedure for these types of tumours.
  • Fifty patients with phyllodes tumours were identified.
  • These comprised 29 benign, 12 borderline and 9 malignant phyllodes tumours.
  • RESULTS: All benign phyllodes tumours were treated with breast-conserving surgery, these included 16 tumours over 40 mm.
  • Malignant and borderline phyllodes tumours had a recurrence rate of 28%.
  • Recurrence occurred in 1/29 benign tumours.
  • CONCLUSIONS: Breast-conserving surgery is the treatment of choice for all benign lesions.
  • [MeSH-major] Breast Neoplasms / surgery. Phyllodes Tumor / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Middle Aged. Neoplasm Recurrence, Local / etiology. Neoplasm Recurrence, Local / pathology. Retrospective Studies

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  • (PMID = 16176692.001).
  • [ISSN] 1478-7083
  • [Journal-full-title] Annals of the Royal College of Surgeons of England
  • [ISO-abbreviation] Ann R Coll Surg Engl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1963973
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37. Suzuki-Uematsu S, Shiraishi K, Ito T, Adachi N, Inage Y, Taeda Y, Ueki H, Ohtani H: Malignant phyllodes tumor composed almost exclusively of a fibrosarcomatous component: a case report and review of malignant phyllodes tumors with metastases. Breast Cancer; 2010 Jul;17(3):218-24
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  • [Title] Malignant phyllodes tumor composed almost exclusively of a fibrosarcomatous component: a case report and review of malignant phyllodes tumors with metastases.
  • Here we present a case of malignant phyllodes tumor which was composed almost exclusively of a fibrosarcomatous component.
  • A 52-year-old Japanese female noted a rapid increase of her right breast tumor.
  • The tumor, 10 x 10 cm in the largest dimension, had somewhat of a pushing margin, and showed a flesh-like appearance with marked necrosis.
  • Microscopically, the tumor showed proliferation of atypical ovoid- or spindle-shaped cells in a myxoid matrix.
  • Multiple sectioning revealed that the tumor had only focal occurrence of elongated tubular structures, and the occurrence of a small component of benign phyllodes tumor, leading to the aforementioned final diagnosis.
  • We reviewed 15 malignant phyllodes tumors with metastases reported in Japan.
  • [MeSH-major] Breast Neoplasms / pathology. Fibrosarcoma / pathology. Lung Neoplasms / secondary. Phyllodes Tumor / secondary

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  • (PMID = 19350353.001).
  • [ISSN] 1880-4233
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
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38. Jones AM, Mitter R, Poulsom R, Gillett C, Hanby AM, Tomlinson IP, Sawyer EJ, Phyllodes Tumour Consortium: mRNA expression profiling of phyllodes tumours of the breast: identification of genes important in the development of borderline and malignant phyllodes tumours. J Pathol; 2008 Dec;216(4):408-17
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  • [Title] mRNA expression profiling of phyllodes tumours of the breast: identification of genes important in the development of borderline and malignant phyllodes tumours.
  • The aim of this study was to identify genes involved in the development of borderline and malignant phyllodes tumours of the breast (PTs).
  • Expression profiling of 23 PTs (12 benign, 11 borderline/malignant) was performed using Affymetrix U133A GeneChips. mRNA expression in the borderline/malignant PTs was compared to the benign PTs.
  • PAX3, TGFB2 and HMGA2 were expressed predominantly in borderline/malignant PTs, but showed some expression in benign tumours; they may be important in the transition from the benign to borderline/malignant phenotype.
  • [MeSH-major] Breast Neoplasms / genetics. Gene Expression Regulation, Neoplastic. Phyllodes Tumor / genetics

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  • (PMID = 18937276.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Grant] United Kingdom / Department of Health / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / RNA, Small Interfering
  • [Investigator] Walker R; Pinder S; Jones L; Ellis I; Tan PH; Macartney J; Green D; Hales S; Harding-Mackean C; Colclough A; MacNeill F; Rowlands D; Smith C; Fentiman I; Cane P; Desai A; Goderya R; Nerurkar A; Kissin M; Jackson P
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39. Mannan AA, Kahvic M, Aziz AH: Phyllodes tumor of the vulva: Report of a rare case and review of the literature. Am J Dermatopathol; 2010 Jun;32(4):384-6
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  • [Title] Phyllodes tumor of the vulva: Report of a rare case and review of the literature.
  • Phyllodes tumor occurring in the vulva is extremely rare; only 6 cases have been previously reported in the literature.
  • The histogenetic origin of this tumor is controversial as it is being debated whether such lesions evolve from ectopic breast tissue, cutaneous apocrine glands, and most recently, anogenital mammary-like gland.
  • Microscopic examination revealed morphologic pattern characteristic of benign phyllodes tumor.
  • We also discuss the histogenesis of phyllodes tumor and related lesions occurring in the anogenital region in light of the current literature along with a brief review of the previously reported cases of vulvar phyllodes tumor.
  • [MeSH-major] Phyllodes Tumor / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 20514681.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
  • [Number-of-references] 11
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40. Hirose M, Hashizume T, Seino N, Kubota H, Nobusawa H, Gokan T: Atlas of breast magnetic resonance imaging. Curr Probl Diagn Radiol; 2007 Mar-Apr;36(2):51-65
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  • Magnetic resonance imaging (MRI) of the breast has become important not only for assessing the extent of breast cancer for breast-conserving surgery but also for the evaluation and diagnosis of other benign and malignant pathologies.
  • We will illustrate the MRI features of various breast pathologies including malignant tumors such as invasive and noninvasive ductal carcinoma, special types of invasive carcinoma (mucinous, apocrine, lobular carcinoma, spindle cell carcinoma, and so on), inflammatory carcinoma, semimalignant tumor (phyllodes tumor), benign tumors (fibroadenoma, intraductal and intracystic papilloma), inflammatory conditions, and postsurgical changes.

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  • (PMID = 17331837.001).
  • [ISSN] 0363-0188
  • [Journal-full-title] Current problems in diagnostic radiology
  • [ISO-abbreviation] Curr Probl Diagn Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 44
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41. Moriya T, Kozuka Y, Kanomata N, Tse GM, Tan PH: The role of immunohistochemistry in the differential diagnosis of breast lesions. Pathology; 2009 Jan;41(1):68-76
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  • It can be used to assist in distinguishing benign and malignant conditions, or to clarify the histological subtype of invasive carcinomas.
  • High molecular weight cytokeratins (CK5/6, CK14, 34betaE12) typically show a mosaic-like pattern of expression in benign papillary/hyperplastic lesions, and are mostly negative in ductal in situ carcinoma, but some exceptions exist.
  • Cytokeratins, especially the antibody 34betaE12, are of value to differentiate spindle cell carcinoma from phyllodes tumour.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Breast Neoplasms / diagnosis. Breast Neoplasms / metabolism. Immunohistochemistry / methods


42. Telli ML, Horst KC, Guardino AE, Dirbas FM, Carlson RW: Phyllodes tumors of the breast: natural history, diagnosis, and treatment. J Natl Compr Canc Netw; 2007 Mar;5(3):324-30
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  • [Title] Phyllodes tumors of the breast: natural history, diagnosis, and treatment.
  • Phyllodes tumors of the breast are unusual fibroepithelial tumors that exhibit a wide range of clinical behavior.
  • These tumors are categorized as benign, borderline, or malignant based on a combination of histologic features.
  • The prognosis of phyllodes tumors is favorable, with local recurrence occurring in approximately 15% of patients overall and distant recurrence in approximately 5% to 10% overall.
  • [MeSH-major] Breast Neoplasms. Phyllodes Tumor

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  • (PMID = 17439760.001).
  • [ISSN] 1540-1405
  • [Journal-full-title] Journal of the National Comprehensive Cancer Network : JNCCN
  • [ISO-abbreviation] J Natl Compr Canc Netw
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 43
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43. Chang DS, McGrath MH: Management of benign tumors of the adolescent breast. Plast Reconstr Surg; 2007 Jul;120(1):13e-19e
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  • [Title] Management of benign tumors of the adolescent breast.
  • SUMMARY: Although 99 percent of breast lesions in female adolescents are benign tumors, surgical intervention is commonly required.
  • This article reviews the differential diagnosis, evaluation, and management of these benign tumors.
  • The authors review the approach to five specific breast lesions: fibroadenomas, phyllodes tumors, juvenile hypertrophy, inflammatory processes, and premature breast development.
  • [MeSH-minor] Adolescent. Age Factors. Biopsy, Needle. Esthetics. Female. Fibroadenoma / pathology. Fibroadenoma / surgery. Follow-Up Studies. Humans. Immunohistochemistry. Mastectomy / methods. Phyllodes Tumor / pathology. Phyllodes Tumor / surgery. Risk Factors. Treatment Outcome

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  • [CommentIn] Plast Reconstr Surg. 2008 Aug;122(2):679-80 [18626406.001]
  • (PMID = 17572540.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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44. Udapudi DG, Vasudeva P, Srikantiah R, Virupakshappa E: Massive benign phyllodes tumor. Breast J; 2005 Nov-Dec;11(6):521
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  • [Title] Massive benign phyllodes tumor.
  • [MeSH-major] Breast Neoplasms / pathology. Breast Neoplasms / surgery. Phyllodes Tumor / pathology. Phyllodes Tumor / surgery

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  • (PMID = 16297126.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Barrio AV, Clark BD, Goldberg JI, Hoque LW, Bernik SF, Flynn LW, Susnik B, Giri D, Polo K, Patil S, Van Zee KJ: Clinicopathologic features and long-term outcomes of 293 phyllodes tumors of the breast. Ann Surg Oncol; 2007 Oct;14(10):2961-70
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  • [Title] Clinicopathologic features and long-term outcomes of 293 phyllodes tumors of the breast.
  • BACKGROUND: Phyllodes tumors (PT) are rare fibroepithelial neoplasms of the breast with unpredictable behavior.
  • RESULTS: All cases occurred in women, with a median age of 42, with 203 originally categorized as benign and 90 as malignant.
  • These patients constituted 71% of the seven patients who had uniformly aggressive pathologic features, including large tumor size (>or=7.0 cm), infiltrative borders, marked stromal overgrowth, marked stromal cellularity, high mitotic count, and necrosis.
  • [MeSH-major] Breast Neoplasms / pathology. Phyllodes Tumor / pathology
  • [MeSH-minor] Actuarial Analysis. Adolescent. Adult. Aged. Aged, 80 and over. Breast / pathology. Cell Division / physiology. Child. Diagnosis, Differential. Disease Progression. Female. Follow-Up Studies. Humans. Middle Aged. Mitosis / physiology. Necrosis. Neoplasm Invasiveness / pathology. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Retrospective Studies. Stromal Cells / pathology

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  • (PMID = 17562113.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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46. Laé M, Vincent-Salomon A, Savignoni A, Huon I, Fréneaux P, Sigal-Zafrani B, Aurias A, Sastre-Garau X, Couturier J: Phyllodes tumors of the breast segregate in two groups according to genetic criteria. Mod Pathol; 2007 Apr;20(4):435-44
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  • [Title] Phyllodes tumors of the breast segregate in two groups according to genetic criteria.
  • Phyllodes tumors are rare fibroepithelial tumors of the breast.
  • The pathologic grading of phyllodes tumors based on the aspect of the stromal component, is divided into 2 or 3 grades according to the system used.
  • To determine whether genetic markers could be of use for improving the classification of phyllodes tumors and to provide a better knowledge of the genetic alterations in these tumors, we analyzed chromosomal changes detected by comparative genomic hybridization (CGH) in comparison with histological data, in a series of 30 cases.
  • Recurrent chromosome imbalances were observed in 55, 91 and 100% of benign, borderline and malignant phyllodes tumors, respectively.
  • The mean number of chromosome changes was one in benign, six in borderline, and six in malignant phyllodes tumors.
  • Gains of 1q, present in only one of nine benign tumors, were found in 11/21 (51%) borderline or malignant tumors.
  • Borderline and malignant phyllodes tumors could not be differentiated on the basis of their genomic imbalances (presence and number of chromosomal changes, presence of 1q gain and/or 13q loss).
  • Conversely, benign tumors could be significantly differentiated from the group composed of borderline and malignant tumors (P<0.01).
  • This study reveals two distinct patterns of genomic imbalance in phyllodes tumors: benign, with none or a few chromosome changes and malignant, with numerous recurrent chromosomal changes, in particular 1q gain and 13q loss.
  • Helpful additional pathological criteria for differentiating the two genetic groups of phyllodes tumors are the nuclear size and the mitotic rate.
  • [MeSH-major] Breast Neoplasms / genetics. Chromosome Aberrations. Phyllodes Tumor / genetics

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  • (PMID = 17334353.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Genetic Markers
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47. Tomita T, Ren Y, Davis M, Tawfik O: Phyllodes tumor of borderline malignancy: seven year follow up with immunohistochemical study. Pathol Int; 2005 Sep;55(9):585-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phyllodes tumor of borderline malignancy: seven year follow up with immunohistochemical study.
  • Originally, a needle biopsy showed benign stromal and ductal cells.
  • Five years later, the breast mass increased in size and a core needle biopsy showed a biphasic intraductal papillomatous tumor with cellular stroma.
  • Eighteen months later, another biopsy was taken from the breast mass, revealing a well-developed phyllodes tumor (PT) of borderline malignancy.
  • Histolopathologic and immunohistochemical studies, including estrogen and progesterone receptors, Ki-67 and p53, performed on tissues from the different biopsy specimens confirmed the progressive transition of the tumor in a 7 year period.
  • [MeSH-major] Breast Neoplasms / pathology. Phyllodes Tumor / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor. Biopsy, Needle. Female. Follow-Up Studies. Humans. Mastectomy, Simple. Mitosis. Time Factors. Treatment Outcome

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  • (PMID = 16143035.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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48. Gojnic M, Dugalic V, Vidaković S, Papic M, Jeremic K, Pervulov M, Milicevic S: Breast cancer and borderline ovarian carcinoma in young patients--case report. Eur J Gynaecol Oncol; 2005;26(5):579-80
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  • Cystosarcoma phyloides is a breast cancer with deterrent features because of its size and fast growth.
  • Regardless of the tumor type (serous, mucinous, clear cell, Brenner, mixed) they can be benign, borderline or malignant.
  • [MeSH-major] Breast Neoplasms / diagnosis. Ovarian Neoplasms / diagnosis. Phyllodes Tumor / diagnosis


49. Morikawa T, Nagata M, Tomita K, Kitamura T, Goto A, Chong JM, Fukayama M: Phyllodes tumor of the prostate with exuberant glandular hyperplasia. Pathol Int; 2006 Mar;56(3):158-61
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  • [Title] Phyllodes tumor of the prostate with exuberant glandular hyperplasia.
  • Reported herein is an unusual case of prostatic phyllodes tumor with exuberant glandular hyperplasia that led to misdiagnosis of adenocarcinoma.
  • The tumor was detected in a 52-year-old man who had a 1 year history of dysuria.
  • Histologically, the tumor had an atypical stromal cell proliferation and elongated slit-like glands characteristic of a phyllodes tumor.
  • The tumor was also accompanied by a florid proliferation of small acini, most of which lacked basal cells, a common manifestation of adenocarcinoma in the overall tumor area.
  • The following features of the resected tumor were helpful for concluding that these acini were benign: lack of cytological anaplasia in spite of structural atypia, presence of scattered basal cells confirmed by immunohistochemistry (high-molecular-weight cytokeratin), and histological transition from these acini to apparently benign slit-like glands.
  • The final diagnosis was then made as 'phyllodes tumor of the prostate with exuberant glandular hyperplasia'.
  • Atypical stromal cells might provide a clue for the recognition of this rare tumor at initial diagnosis by needle biopsy.
  • [MeSH-major] Biopsy, Needle. Diagnostic Errors. Phyllodes Tumor / pathology. Prostatic Neoplasms / pathology

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  • (PMID = 16497250.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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50. Aranda C, Sotelo M, Torres A, Zárate M: [Phyllodes tumor and pregnancy. A report of a case]. Ginecol Obstet Mex; 2005 Jul;73(7):387-92
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  • [Title] [Phyllodes tumor and pregnancy. A report of a case].
  • [Transliterated title] Tumor phyllodes y embarazo. Reporte de un caso.
  • Phyllodes tumor is a rare breast fibroepithelial neoplasm of the breast, predominant in females (0.3 to 0.5%).
  • Phyllodes tumor during pregnancy grows fast and its size is relatively big.
  • These tumors can be classified as benign, malignant or neighboring.
  • A possible phyllodes tumour in the right breast was observed during surgery, weight 9.6 pounds, with partial infiltration to major pectoral muscle.
  • Pathology reported a benign phyllodes tumor in the right breast, with surgical borders free of tumor.
  • Phyllodes tumor is rare and can occur during pregnancy.
  • It is unknown if the tumor is hormone-dependent.
  • The growth of a tumor on a subsequent pregnancy is not necessarily associated with recurrency or with a new disorder on the patient, who has had a complete excision.
  • [MeSH-major] Breast Neoplasms. Phyllodes Tumor. Pregnancy Complications, Neoplastic


51. Hossain D, Meiers I, Qian J, MacLennan GT, Bostwick DG: Prostatic stromal hyperplasia with atypia: follow-up study of 18 cases. Arch Pathol Lab Med; 2008 Nov;132(11):1729-33
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  • RESULTS: Prostatic stromal hyperplasia with atypia consists of 1 or more ill-defined, uncircumscribed, hyperplastic stromal nodules, with variable numbers of atypical, bizarre giant cells, with vacuolated nuclei, smudged chromatin, and frequent multinucleation infiltrating around benign acini.
  • CONCLUSIONS: Prostatic stromal hyperplasia with atypia is a rare, benign lesion, composed of degenerative myocytes with atypia that is histologically and clinically reminiscent of benign counterparts in the myometrium, breast, vulva, vagina, and elsewhere.
  • Recognition of this distinctive entity should allow separation from phyllodes tumor and sarcoma of the prostate.
  • The phrase stromal tumor of uncertain malignant potential is inappropriate for this benign tumor, and its use is discouraged.

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  • (PMID = 18976007.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Androgen; 0 / Vimentin
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52. Ben Hassouna J, Damak T, Gamoudi A, Chargui R, Khomsi F, Mahjoub S, Slimene M, Ben Dhiab T, Hechiche M, Boussen H, Rahal K: Phyllodes tumors of the breast: a case series of 106 patients. Am J Surg; 2006 Aug;192(2):141-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phyllodes tumors of the breast: a case series of 106 patients.
  • BACKGROUND: Phyllodes tumors (PTs) of the breast are rare, and their prognosis and treatment are still subject of discussion.
  • According to criteria of Azzopardi and Salvadori, tumors were classified into 3 groups: benign (62 cases, 58.4%), borderline (16 cases, 15%), and malignant (28 cases, 26.4%).
  • Eighty-two patients (77.4%) were treated conservatively (62 benign, 11 borderline, and 9 malignant) and 24 (22.6%) by radical surgery (5 borderline and 19 malignant).
  • For malignant PTs treated by enucleation or local excision with or without reexcision of the tumor bed, the 5-year overall and disease-free survivals were 28.5% and 15.6% versus 72.7% and 73.6% when the surgery was radical (mastectomy with or without axillary dissection) (P = .12 and P = .0022).
  • The rate of recurrence was 12.2% (13) after a mean follow-up of 39 months (5 benign, 2 borderline, and 5 malignant).
  • In univariate analysis, age and recurrences are not of prognostic value for survival, whereas tumor size, histotype, necrosis, cytonuclear atypia, tumor margins, and number of mitosis were significant prognostic factors for survival.
  • CONCLUSION: According to our results, we recommend for malignant PT a simple mastectomy, whereas for borderline and benign PT, treatment is based rather on wide excision passing in healthy tissue.
  • [MeSH-major] Breast Neoplasms / diagnosis. Mastectomy / methods. Phyllodes Tumor / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Diagnosis, Differential. Disease-Free Survival. Female. Follow-Up Studies. Humans. Mammography. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Rate. Ultrasonography, Mammary

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  • (PMID = 16860620.001).
  • [ISSN] 0002-9610
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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53. Akin M, Irkorucu O, Koksal H, Gonul II, Gultekin S, Kurukahvecioglu O, Anadol AZ, Tekin E: Phyllodes tumor of the breast; a case series. Bratisl Lek Listy; 2010;111(5):271-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phyllodes tumor of the breast; a case series.
  • BACKGROUND: Phyllodes tumor (PT) is a rare neoplasm comprising less than 1% of all breast tumors.
  • Its clinical spectrum ranges from a benign and locally recurrent form of behavior to malignant and metastatic forms.
  • All cases were histologically examined by an experienced breast pathologist, and tumors were classified as benign, borderline malignant or malignant according to standard histological criteria.
  • Seven (70%) of 10 tumors were benign and 3 (30%) were malignant.
  • The median tumor size was 29 mm (range: 12-80 mm).
  • CONCLUSION: PT is a rare neoplasm of the breast.
  • It resembles fibroadenoma.
  • [MeSH-major] Breast Neoplasms. Phyllodes Tumor

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  • (PMID = 20568416.001).
  • [ISSN] 0006-9248
  • [Journal-full-title] Bratislavské lekárske listy
  • [ISO-abbreviation] Bratisl Lek Listy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovakia
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54. Abdalla HM, Sakr MA: Predictive factors of local recurrence and survival following primary surgical treatment of phyllodes tumors of the breast. J Egypt Natl Canc Inst; 2006 Jun;18(2):125-33
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  • [Title] Predictive factors of local recurrence and survival following primary surgical treatment of phyllodes tumors of the breast.
  • BACKGROUND AND PURPOSE: The phyllodes tumor is characterized by its tendency to recur locally and occasionally to metastasize.
  • Local recurrence and death from metastases are occasional, but consistent, theme in reports of patients with phyllodes tumors (PTs).
  • The aim of this study was to determine parameters that influence outcome in this uncommon neoplasm.
  • PATIENTS AND METHODS: Data from 79 patients with phyllodes tumors were reviewed retrospectively, reclassifying the pathological material using the World Health Organization (WHO) criteria.
  • The tumor size ranged from 2.5 to 24 cm, with a median of 11 cm.
  • Based on the criteria proposed by WHO, 31 cases were benign tumors (39.2%), 27 borderline tumors (34.2%), and 21 malignant tumors (26.6%).
  • Following local excision, the local recurrence rates were 14.3%, 50%, and 75% in patients with benign, borderline, and malignant tumors; respectively, while after wide local excision the local recurrence rates were 0%, 36.3% and 40%; respectively.
  • Whereas, 0%, 8.3%, and 8.3% of patients with benign, borderline and malignant tumors; respectively, locally recurred after mastectomy.
  • Distant metastases developed in 3.2%, 11.1%, and in 28.6% of patients with benign, borderline and malignant tumors; respectively.
  • The 5-year survival with no evidence of disease was 90% for the patients with benign tumors compared to 69% for borderline and 61% for malignant PTs (p= 0.02).
  • CONCLUSIONS: The histotype of phyllodes tumors and resection margins were the principal determinants of local recurrence and distant metastases.
  • Complete surgical excision by either wide local excision or mastectomy if necessary is important in the primary surgical treatment of phyllodes tumors.
  • [MeSH-major] Breast Neoplasms / pathology. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / mortality. Phyllodes Tumor / pathology

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  • (PMID = 17496937.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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55. Istvanic S, Fischer AH, Banner BF, Eaton DM, Larkin AC, Khan A: Cell blocks of breast FNAs frequently allow diagnosis of invasion or histological classification of proliferative changes. Diagn Cytopathol; 2007 May;35(5):263-9
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  • One cystosarcoma phyllodes was suspected based on the cell block sections.
  • Cell blocks from 12 of 14 benign breast FNAs showed sufficient cells to assign a histologic diagnosis of no hyperplasia (1 case, confirmed on follow-up) and usual hyperplasia (11 cases; confirmed in eight of 11 on follow-up).
  • [MeSH-minor] Adenocarcinoma / classification. Adenocarcinoma / pathology. Carcinoma in Situ / classification. Carcinoma in Situ / pathology. Carcinoma, Lobular / classification. Carcinoma, Lobular / pathology. Cell Proliferation. Female. Humans. Hyperplasia. Neoplasm Invasiveness. Papilloma, Intraductal / classification. Papilloma, Intraductal / pathology. Phyllodes Tumor / classification. Phyllodes Tumor / pathology

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17427225.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Uner A, Ozturk B, Benekli M, Coskun U, Kocak S, Kaya AO, Unsal D, Erekul S, Yaman E, Yildiz R, Buyukberber S: Synchronize primary breast osteosarcoma and contralateral benign cystosarcoma phylloides: radiologic and pathologic imaging. Breast J; 2008 Jan-Feb;14(1):109-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronize primary breast osteosarcoma and contralateral benign cystosarcoma phylloides: radiologic and pathologic imaging.
  • [MeSH-major] Breast Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Osteosarcoma / pathology. Phyllodes Tumor / pathology


57. Khurshid A, Kayani N, Bhurgri Y: Phylloides tumors in adolescent girls and young women in Pakistan. Asian Pac J Cancer Prev; 2006 Oct-Dec;7(4):563-6
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  • The objective of this study was to determine the frequency of phylloides tumor (PT) in adolescent girls and young women (less than and equal to 25 years of age) and to define the clinico-pathological features of PT in this unusual clinical setting.
  • The number of benign (BPT), borderline (BLPT) and malignant (MPT) was identical i.e.
  • High grade PT (BLPT and MPT) is an uncommon mammary tumor in adolescent girls and young women but seems to be occurring with increased frequency in the study population.
  • [MeSH-major] Breast Neoplasms / epidemiology. Phyllodes Tumor / epidemiology

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  • (PMID = 17250427.001).
  • [ISSN] 1513-7368
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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58. Dillon MF, Quinn CM, McDermott EW, O'Doherty A, O'Higgins N, Hill AD: Needle core biopsy in the diagnosis of phyllodes neoplasm. Surgery; 2006 Nov;140(5):779-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Needle core biopsy in the diagnosis of phyllodes neoplasm.
  • BACKGROUND: Accurate identification of phyllodes neoplasms without surgical intervention is difficult, reducing the ability to manage "benign" lumps non-operatively and impacting on the open benign biopsy rate.
  • Its accuracy in the diagnosis of phyllodes neoplasm has not been established.
  • RESULTS: Twenty-three patients had phyllodes neoplasm on excisional biopsy with prior core biopsy findings as follows: phyllodes neoplasm (n=2), "equivocal" for phyllodes neoplasm (n=12), fibroadenoma (n=3), benign (n=6).
  • The false negative rate for phyllodes neoplasm was therefore 39% (n=9/23).
  • Of the total biopsy series, 35 patients had a core biopsy suggesting the possibility of phyllodes neoplasm.
  • Of these, 32% (n=11) were found to be phyllodes neoplasm on excision, 3% (n=1) phyllodes neoplasm with breast carcinoma, 6% (n=2) breast carcinoma, and 3% (n=1) sarcoma.
  • When a preference for phyllodes neoplasm (n=4) was stated on the equivocal core biopsies, excision correlated with the stated preference; this correlation also occurred in 90% (n=9/10) of core biopsies where fibroadenoma was favored.
  • CONCLUSIONS: Needle core biopsy rarely produces a definite preoperative diagnosis of phyllodes neoplasm.
  • A diagnosis of fibroadenoma or equivocal phyllodes neoplasm on core biopsy should not prevent excision if clinical suspicion remains.
  • [MeSH-major] Biopsy, Needle / methods. Breast Neoplasms / diagnosis. Diagnostic Errors. Phyllodes Tumor / diagnosis

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  • (PMID = 17084721.001).
  • [ISSN] 0039-6060
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Huang KT, Dobrovic A, Yan M, Karim RZ, Lee CS, Lakhani SR, Fox SB: DNA methylation profiling of phyllodes and fibroadenoma tumours of the breast. Breast Cancer Res Treat; 2010 Nov;124(2):555-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] DNA methylation profiling of phyllodes and fibroadenoma tumours of the breast.
  • Phyllodes tumours and cellular fibroadenomas are both fibroepithelial tumours of the breast.
  • Phyllodes tumours, unlike fibroadenomas, have the ability to recur and metastasise.
  • We sought to evaluate whether DNA promoter methylation profiling using selected genes known to be methylated in cancer would allow us to learn more about the biology of these tumours, and whether it could identify methylation markers that could differentiate phyllodes tumours from fibroadenomas and/or distinguish phyllodes tumours of different grades.
  • Methylation-sensitive high resolution melting (MS-HRM) was used to screen promoter DNA methylation changes in 86 phyllodes tumours (15 benign, 28 borderline, 43 malignant) and 26 fibroadenomas.
  • Five of the gene promoters showed some methylation in a proportion of phyllodes tumours; RASSF1A, 45.3%; TWIST1, 10.7%; APC, 4.1%; WIF1, 2.9% and MGMT, 1.3%.
  • No CDKN2A methylation was observed in either tumour type, contrary to previous reports.
  • However, significant levels of methylation of RASSF1A (24.4%) and TWIST1 (7.1%) was observed in some phyllodes tumours.
  • Elevated RASSF1A and/or TWIST1 methylation was significantly associated with phyllodes tumours compared with fibroadenomas (P = 0.02), TWIST1 methylation correlated with increasing malignancy in phyllodes tumours (P < 0.001).
  • In conclusion, assessment of methylation of RASSF1A and TWIST1 may aid in the diagnosis of phyllodes tumours.
  • [MeSH-major] Biomarkers, Tumor / genetics. Breast Neoplasms / genetics. DNA Methylation. Fibroadenoma / genetics. Gene Expression Profiling. Genetic Markers. Phyllodes Tumor / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Australia. Chi-Square Distribution. Female. Humans. Logistic Models. Middle Aged. Nuclear Proteins / genetics. Promoter Regions, Genetic. Risk Assessment. Risk Factors. Tumor Suppressor Proteins / genetics. Twist Transcription Factor / genetics. Young Adult

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  • (PMID = 20563638.001).
  • [ISSN] 1573-7217
  • [Journal-full-title] Breast cancer research and treatment
  • [ISO-abbreviation] Breast Cancer Res. Treat.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Genetic Markers; 0 / Nuclear Proteins; 0 / RASSF1 protein, human; 0 / TWIST1 protein, human; 0 / Tumor Suppressor Proteins; 0 / Twist Transcription Factor
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60. Aguilar B, Villalobos M, Sotomayor M: Phyllodes tumor of the prostate. Urology; 2009 Feb;73(2):272
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  • [Title] Phyllodes tumor of the prostate.
  • The patient underwent tumor resection, and the histologic diagnosis was benign cystic Phyllodes tumor of the prostate.
  • Phyllodes tumor of the prostate is a rare tumor composed of hyperplastic and neoplastic glandular-stromal proliferation.
  • The tumor grade has an effect on the prognosis, although if not completely resected, even low-grade tumors can recur, metastasize, or differentiate into sarcoma.
  • [MeSH-major] Phyllodes Tumor / diagnosis. Prostatic Neoplasms / diagnosis

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  • (PMID = 18930515.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Goel NB, Knight TE, Pandey S, Riddick-Young M, de Paredes ES, Trivedi A: Fibrous lesions of the breast: imaging-pathologic correlation. Radiographics; 2005 Nov-Dec;25(6):1547-59
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  • Fibroadenomas, benign lesions that derive from the terminal duct lobular unit, are the most common and are often identified at clinical examination or mammography as circumscribed masses.
  • Benign mesenchymal tumors include focal fibrosis, pseudoangiomatous stromal hyperplasia, and fibromatosis or desmoid tumor.
  • Phyllodes tumor, which is similar to fibroadenoma but has increased cellularity in the stroma, is typically benign but has malignant potential.
  • Except for fibromatosis and phyllodes tumor, fibroepithelial lesions need not be excised if the diagnosis is confirmed by the results of histologic analysis at percutaneous biopsy.
  • To correctly differentiate between fibrous breast lesions that are benign and those that should be resected, the physician must be familiar with the correlated radiologic-pathologic findings in the various lesion types.

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  • [Copyright] RSNA, 2005.
  • (PMID = 16284134.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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62. Tomimaru Y, Komoike Y, Egawa C, Motomura K, Inaji H, Kataoka TR, Koyama H: A case of phyllodes tumor of the breast with a lesion mimicking fibroadenoma. Breast Cancer; 2005;12(4):322-6
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  • [Title] A case of phyllodes tumor of the breast with a lesion mimicking fibroadenoma.
  • We report a case of phyllodes tumor (PT) with multiple lesions partly mimicking fibroadenoma (FA).
  • On histological examination, the tumor consisted of three different components; a lesion diagnosed as FA, another lesion as benign PT, and the other lesion as borderline PT.
  • Finally, the tumor was diagnosed as borderline PT.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / diagnosis. Fibroadenoma / diagnosis. Phyllodes Tumor / diagnosis

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  • (PMID = 16286914.001).
  • [ISSN] 1340-6868
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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63. Vargas HI, Vargas MP, Gonzalez K, Burla M, Khalkhali I: Percutaneous excisional biopsy of palpable breast masses under ultrasound visualization. Breast J; 2006 Sep-Oct;12(5 Suppl 2):S218-22
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  • Our goal was to determine whether ultrasound-guided vacuum-assisted core biopsy (US-VACB) is safe and effective in completely removing presumed benign palpable breast masses.
  • We conducted a cohort study of 201 consecutive patients with presumed benign palpable masses who underwent removal with US-VACB.
  • Palpable masses were successfully removed with US-VACB in 99% of cases; 2% were cancer and 7.5% were atypical ductal hyperplasia or phyllodes tumor.
  • US-VACB is safe and effective in the initial diagnosis and management of presumed benign palpable breast masses.
  • It provides the benefits of percutaneous biopsy and the palpable abnormality no longer remains.

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  • (PMID = 16959005.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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64. Lien HC, Lu YS, Cheng AL, Chang WC, Jeng YM, Kuo YH, Huang CS, Chang KJ, Yao YT: Differential expression of glucocorticoid receptor in human breast tissues and related neoplasms. J Pathol; 2006 Jul;209(3):317-27
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  • In order to generate a comprehensive expression profile for GR in normal versus neoplastic breast tissues, GR expression was investigated in situ in 400 human breast tissue samples, comprising normal tissue and a range of benign, pre-invasive, and invasive lesions, using immunohistochemical assays.
  • The strong expression of GR in metaplastic carcinomas (94.4%) and malignant phyllodes tumours (92.3%) suggests a pathogenetic role for GR, and implies that targeting GR in these tumours may have potential therapeutic application.
  • [MeSH-minor] Base Sequence. Carcinoma, Intraductal, Noninfiltrating / genetics. Carcinoma, Intraductal, Noninfiltrating / metabolism. Carcinoma, Lobular / genetics. Carcinoma, Lobular / metabolism. DNA Methylation. DNA, Neoplasm / genetics. Epithelial Cells / metabolism. Female. Gene Expression. Humans. Immunoenzyme Techniques. Molecular Sequence Data. Neoplasm Invasiveness. Phyllodes Tumor / genetics. Phyllodes Tumor / metabolism. Promoter Regions, Genetic / genetics

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  • [Copyright] Copyright (c) 2006 Pathological Society of Great Britain and Ireland.
  • (PMID = 16639692.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Receptors, Glucocorticoid
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65. Djordjevic B, Hanna WM: Expression of c-kit in fibroepithelial lesions of the breast is a mast cell phenomenon. Mod Pathol; 2008 Oct;21(10):1238-45
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  • The expression of c-kit, a protooncogene tyrosine kinase receptor (CD117), in phyllodes tumors of the breast has been the subject of recent investigations.
  • We examined stromal c-kit expression by immunohistochemistry in 68 cases comprising fibroadenomas, fibroadenomas with cellular stroma, and benign, borderline, and malignant phyllodes tumors.
  • One borderline and one malignant phyllodes tumor showed a diffuse weak stromal signal, which could not be accounted for by toluidine blue and tryptase.
  • C-kit, therefore, has neither a diagnostic nor a prognostic role in phyllodes tumors, and there is no rationale for the treatment of recurrent of malignant phyllodes tumor patients with tyrosine kinase inhibitors.
  • [MeSH-major] Breast Neoplasms / metabolism. Mast Cells / metabolism. Phyllodes Tumor / metabolism. Proto-Oncogene Proteins c-kit / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. DNA Mutational Analysis. DNA, Neoplasm / analysis. Female. Fibroadenoma / metabolism. Fibroadenoma / pathology. Humans. Immunohistochemistry. Mastectomy. Stromal Cells / metabolism. Stromal Cells / pathology

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  • (PMID = 18500266.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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66. Yabuuchi H, Soeda H, Matsuo Y, Okafuji T, Eguchi T, Sakai S, Kuroki S, Tokunaga E, Ohno S, Nishiyama K, Hatakenaka M, Honda H: Phyllodes tumor of the breast: correlation between MR findings and histologic grade. Radiology; 2006 Dec;241(3):702-9
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  • [Title] Phyllodes tumor of the breast: correlation between MR findings and histologic grade.
  • PURPOSE: To retrospectively evaluate the magnetic resonance (MR) imaging findings of phyllodes tumor of the breast and to compare these findings with the histologic grade.
  • The authors reviewed the MR findings in 30 female patients aged 16-73 years (mean, 40.2 years) with surgically confirmed phyllodes tumors.
  • Analyzed MR findings included tumor shape, margin, internal enhancement, and size; signal intensity (SI) of tumor higher than that of normal breast tissue on T1-weighted images; SI of tumor lower than or equal to that of normal tissue on T2-weighted images; cyst wall appearance; kinetic curve assessment; and apparent diffusion coefficient (ADC).
  • RESULTS: Nineteen benign, six intermediate (characterized by five to nine cell reproductions at 10 high-power fields, pushing or infiltrative margins, moderate stromal cellularity, and atypia and overgrowth), and five malignant phyllodes tumors were assessed.
  • Irregular cyst wall (P = .003), tumor SI lower than or equal to normal tissue SI on T2-weighted images (P = .005), and low ADC (P = .001) correlated significantly with histologic grade.
  • Tumor SI higher than normal tissue SI on T1-weighted images was more frequent in the malignant (in three of five tumors) and intermediate (in three of six tumors) groups than in the benign group (in two of 19 tumors); however, it was not a significant finding (P = .024).
  • Tumor SI higher than normal tissue SI on T1-weighted images and irregular cyst wall corresponded histopathologically to hemorrhagic infarction and necrosis, respectively.
  • Tumor SI lower than or equal to normal tissue SI on T2-weighted images and low ADC corresponded histopathologically to stromal hypercellularity.
  • CONCLUSION: Several MR findings can be used to help determine the histologic grade of phyllodes breast tumors.
  • [MeSH-major] Breast Neoplasms / pathology. Magnetic Resonance Imaging / methods. Phyllodes Tumor / pathology


67. Grenier J, Delbaldo C, Zelek L, Piedbois P: [Phyllodes tumors and breast sarcomas: a review]. Bull Cancer; 2010 Oct;97(10):1197-207
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  • [Title] [Phyllodes tumors and breast sarcomas: a review].
  • [Transliterated title] Tumeurs phyllodes et sarcomes du sein: mise au point.
  • Phyllodes tumors and sarcomas of the breast are non-epithelial tumors of the breast.
  • Phyllodes tumors are benign tumors, tumors of intermediate malignancy or malignant tumors.
  • The differential diagnosis with a very proliferant fibroadenoma may be difficult.
  • Radiotherapy is recommended in case of high-grade tumor and after conservativetreatment.
  • Grade, involved margins and sometimes tumor necrosis are major prognostics factors.
  • In some situations, a conservative treatment can be discussed, based on tumor size, grade and volume of the breast.
  • [MeSH-major] Breast Neoplasms / pathology. Phyllodes Tumor / pathology. Sarcoma / pathology
  • [MeSH-minor] Female. Hemangiosarcoma / pathology. Hemangiosarcoma / secondary. Hemangiosarcoma / therapy. Humans. Neoplasm Recurrence, Local. Prognosis

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  • (PMID = 20855241.001).
  • [ISSN] 1769-6917
  • [Journal-full-title] Bulletin du cancer
  • [ISO-abbreviation] Bull Cancer
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
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68. Foxcroft LM, Evans EB, Porter AJ: Difficulties in the pre-operative diagnosis of phyllodes tumours of the breast: a study of 84 cases. Breast; 2007 Feb;16(1):27-37
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  • [Title] Difficulties in the pre-operative diagnosis of phyllodes tumours of the breast: a study of 84 cases.
  • Eighty-four phyllodes tumours (71 benign, eight borderline and five malignant) diagnosed over a 16-year period were studied retrospectively, to assess the diagnostic value of the pre-operative modalities used.
  • The possibility of phyllodes tumour was raised in only 23% on fine needle aspiration cytology, and in 65% on core biopsy.
  • For phyllodes tumours whose growth was measured, almost all had growth rates greater than for growing fibroadenomas.
  • The pre-operative diagnosis of phyllodes tumours is difficult, and rapid growth and/or large size of apparent fibroadenomas may be the only imaging findings to suggest phyllodes tumour.
  • Whole breast ultrasound showed that nearly one third of women with phyllodes tumours had concurrent fibroadenomas.
  • [MeSH-major] Breast Neoplasms / diagnosis. Phyllodes Tumor / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy, Fine-Needle. Female. Fibroadenoma / diagnosis. Humans. Middle Aged. Retrospective Studies

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  • (PMID = 16876413.001).
  • [ISSN] 0960-9776
  • [Journal-full-title] Breast (Edinburgh, Scotland)
  • [ISO-abbreviation] Breast
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
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69. Tan PH: 2005 Galloway Memorial Lecture: Breast phyllodes tumours--morphology and beyond. Ann Acad Med Singapore; 2005 Dec;34(11):671-7
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  • [Title] 2005 Galloway Memorial Lecture: Breast phyllodes tumours--morphology and beyond.
  • OBJECTIVES: The aims of this study were to evaluate the predictive role of morphology in a series of breast phyllodes tumours (PTs) in Asian women, and to determine the utility of immunohistochemical expression of p53 and CD117 in the stromal component.
  • MATERIALS AND METHODS: Breast PTs, diagnosed between January 1992 and December 2002 at the Department of Pathology, Singapore General Hospital, were classified into benign, borderline and malignant categories.
  • Tumour size ranged from 0.9 to 25 cm (median, 4 cm).
  • Histologic classification revealed 250 (74.6%) benign, 54 (16.1%) borderline and 31 (9.3%) malignant PTs.
  • Though tumour grade was associated with an increased hazard of 1.63, it was not significant (P = 0.28).
  • [MeSH-major] Breast Neoplasms / pathology. Phyllodes Tumor / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Immunohistochemistry. Middle Aged. Neoplasm Recurrence, Local. Proto-Oncogene Proteins c-kit / analysis. Survival Rate. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 16453039.001).
  • [ISSN] 0304-4602
  • [Journal-full-title] Annals of the Academy of Medicine, Singapore
  • [ISO-abbreviation] Ann. Acad. Med. Singap.
  • [Language] eng
  • [Publication-type] Lectures; Research Support, Non-U.S. Gov't
  • [Publication-country] Singapore
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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71. Yohe S, Yeh IT: "Missed" diagnoses of phyllodes tumor on breast biopsy: pathologic clues to its recognition. Int J Surg Pathol; 2008 Apr;16(2):137-42
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  • [Title] "Missed" diagnoses of phyllodes tumor on breast biopsy: pathologic clues to its recognition.
  • Fibroadenoma and phyllodes tumors of the breast exhibit a continuum of pathologic features.
  • We examined phyllodes tumors initially called fibroadenoma for features that may accurately classify the tumor as phyllodes tumor on the first biopsy specimen.
  • The phyllodes tumors initially called fibroadenoma for features that may accurately classify the tumor as phyllodes tumors on the first biopsy specimen are examined.
  • Fifteen patients with phyllodes tumors were studied, initially called FA or another term short of PT.
  • Resected phyllodes tumors were larger on average than fibroadenoma, 6.8 cm (range = 1.7-16.2 cm) versus 2.6 cm (range = 1.0-4.8 cm).
  • Ki-67 showed higher proliferation indices in phyllodes tumors versus fibroadenoma (4.8% vs 0.6%).
  • Features suggesting phyllodes tumors include tissue fragmentation, increased stromal cellularity especially around glands, stromal overgrowth, and increased mitoses.
  • Increased sampling of a large tumor will likely yield more correct diagnoses.
  • [MeSH-major] Breast Neoplasms / diagnosis. Diagnostic Errors. Phyllodes Tumor / diagnosis
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Biopsy, Needle. Cell Nucleus / chemistry. Cell Nucleus / pathology. Diagnosis, Differential. Female. Fibroadenoma / diagnosis. Humans. Ki-67 Antigen / analysis

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  • (PMID = 18417670.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen
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72. Sorelli PG, Thomas D, Moore A, Khan M, Hoque H: Malignant phyllodes tumor in an 11-year-old premenarchal girl. J Pediatr Surg; 2010 Feb;45(2):e17-20
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  • [Title] Malignant phyllodes tumor in an 11-year-old premenarchal girl.
  • Phyllodes tumor is uncommon in children, and the malignant form is rare.
  • There have only been a few cases of benign phyllodes tumor reported in peripubertal children and only one malignant case.
  • We report the second case of malignant phyllodes tumor in a premenarchal 11-year-old girl.
  • [MeSH-major] Breast Neoplasms / pathology. Breast Neoplasms / surgery. Phyllodes Tumor / pathology. Phyllodes Tumor / surgery
  • [MeSH-minor] Age Factors. Child. Diagnosis, Differential. Female. Humans. Menarche. Neoplasm Metastasis / pathology. Treatment Outcome

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20152333.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Shah SN: Giant myofibroblastoma of breast: a case report. Indian J Pathol Microbiol; 2007 Jul;50(3):583-5
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  • Myofibroblastoma of the breast is a very rare benign neoplasm usually seen in elderly male and is of very small size.
  • The case was clinically diagnosed as Phyllodes tumor Left mastectomy was done.
  • The tumor was histopathologically and immunohistochemically diagnosed as Myofibroblastoma.

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  • (PMID = 17883145.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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74. Agarwal P, Sparnon AL: Benign breast lesions in adolescent girls: an overview with a case report. Pediatr Surg Int; 2005 May;21(5):381-2
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  • [Title] Benign breast lesions in adolescent girls: an overview with a case report.
  • We report a case in an adolescent girl that was initially diagnosed and treated as fibroadenoma until a histological assessment proved it to be a phyllodes tumour with malignant potential.
  • [MeSH-major] Breast Neoplasms / diagnosis. Phyllodes Tumor / diagnosis
  • [MeSH-minor] Adolescent. Breast Diseases / diagnosis. Female. Fibroadenoma / diagnosis. Humans

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  • [Cites] Am J Surg. 1983 Dec;146(6):712-4 [6316797.001]
  • [Cites] Cancer. 1978 May;41(5):1974-83 [206344.001]
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  • (PMID = 15742186.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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75. Sakurai K, Enomoto K, Amano S: [Long-term results of surgical therapy for phyllodes tumor of the breast]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2784-5
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  • [Title] [Long-term results of surgical therapy for phyllodes tumor of the breast].
  • We report that the long-term results of surgical therapy for phyllodes tumor of the breast.
  • During ten years, we experienced twenty-eight patients of phyllodes tumors of the breast.
  • The patients with local recurrence were diagnosed the benign phyllodes tumor of the breast at the first operation.
  • If the pathological diagnosis was benign phyllodes tumor and surgical margin was negative at the first operation, it is necessary to follow up the patients, because there is a risk of local and distant metastasis.
  • [MeSH-major] Breast Neoplasms / surgery. Phyllodes Tumor / surgery
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Mastectomy / methods. Middle Aged. Neoplasm Recurrence, Local. Treatment Outcome

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  • (PMID = 21224712.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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76. Sabban F, Collinet P, Lucot JP, Boman F, Leroy JL, Vinatier D: [Phyllodes tumor of the breast: analysis of 8 patients]. J Gynecol Obstet Biol Reprod (Paris); 2005 May;34(3 Pt 1):252-6
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  • [Title] [Phyllodes tumor of the breast: analysis of 8 patients].
  • [Transliterated title] Tumeurs phyllodes du sein: à propose de 8 patientes.
  • INTRODUCTION: Phyllodes tumors of breast are rare and usually benign.
  • MATERIALS AND METHODS: We reviewed 8 cases of phyllodes tumors and the literature to report the circumstances of occurrence of these tumors, and their specific clinical diagnosis, therapeutic, prognostic features.
  • Mean tumor size was 3.75 cm.
  • Aspiration cytology demonstrated the phyllode tumor in 43% of patients.
  • [MeSH-major] Breast Neoplasms / diagnosis. Phyllodes Tumor / diagnosis

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  • (PMID = 16012385.001).
  • [ISSN] 0368-2315
  • [Journal-full-title] Journal de gynécologie, obstétrique et biologie de la reproduction
  • [ISO-abbreviation] J Gynecol Obstet Biol Reprod (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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77. Agabiti S, Gurrera A, Amico P, Vasquez E, Magro G: [Mammary hamartoma with atypical stromal cells: a potential diagnostic dilemma]. Pathologica; 2007 Dec;99(6):434-7
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  • Although atypical stromal cell (ASCs) can be encountered in several benign and malignant breast lesions, their occurrence in hamartoma has not been reported to date.
  • This unusual feature raised differential diagnostic problems with pleomorphic lipoma, well-differentiated liposarcoma and malignant phylloid tumour with a lipomatous heterologous component.
  • [MeSH-minor] Antigens, CD34 / analysis. Biomarkers. Breast Neoplasms / diagnosis. Diagnosis, Differential. Female. Fibroblasts / chemistry. Fibroblasts / pathology. Humans. Lipoma / diagnosis. Liposarcoma / diagnosis. Middle Aged. Phyllodes Tumor / diagnosis. Stromal Cells / chemistry. Stromal Cells / pathology. Vimentin / analysis

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  • (PMID = 18416336.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers; 0 / Vimentin
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78. Verma S, Singh RK, Rai A, Pandey CP, Singh M, Mohan N: Extent of surgery in the management of phyllodes tumor of the breast: a retrospective multicenter study from India. J Cancer Res Ther; 2010 Oct-Dec;6(4):511-5
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  • [Title] Extent of surgery in the management of phyllodes tumor of the breast: a retrospective multicenter study from India.
  • INTRODUCTION: Phyllodes tumor (PT) is a rare tumor of the breast.
  • OBJECTIVES: The objective of this retrospective study is to study the clinicopathological correlation of phyllodes tumors in North-Central part of the India and also to evaluate efficacy of the various surgical options available for the management of phyllodes tumors of the breast.
  • Histopathological report was benign, borderline, and malignant PT in 62.4%, 20.8%, and 16.8% of the cases, respectively.
  • This study shows that wide local excision for benign and borderline and simple mastectomy with or without reconstruction for the malignant PT of the breast are acceptable best surgical options.
  • [MeSH-major] Breast Neoplasms / surgery. Phyllodes Tumor / surgery

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  • (PMID = 21358091.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] India
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79. McKenna AM, Pintilie M, Youngson B, Done SJ: Quantification of the morphologic features of fibroepithelial tumors of the breast. Arch Pathol Lab Med; 2007 Oct;131(10):1568-73
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  • [Title] Quantification of the morphologic features of fibroepithelial tumors of the breast.
  • CONTEXT: Phyllodes tumors of the breast are uncommon, comprising 0.3% to 0.9% of female primary breast tumors.
  • Owing in part to their rarity, definitive, objective, reproducible morphologic criteria that reliably distinguish benign from low-grade malignant or malignant phyllodes tumors have yet to be established.
  • OBJECTIVE: To use image analysis to quantitate and compare morphologic features of different groups of fibroepithelial tumors (FETs) of the breast.
  • DESIGN: Hematoxylin-eosin-stained sections of 41 FETs previously identified as fibroadenoma, benign phyllodes, low-grade malignant phyllodes, or high-grade malignant phyllodes were blinded and studied using a Leica DMRA2 microscope and OpenLab Image Analysis software.
  • Features of each case including tumor size, margin status, and the presence of necrosis or heterologous elements were also considered; these data were retrieved from surgical pathology reports.
  • RESULTS: Quantitative measures of stromal cellularity, stromal-epithelial ratio, mitotic rate, stromal overgrowth, and mean nuclear diameter were developed and found to stratify a population of FETs by the current classification system of fibroadenoma, benign, and low-grade or high-grade malignant phyllodes tumor.
  • CONCLUSIONS: Quantitative morphologic features of FETs can be used to stratify these tumors by subtype.
  • [MeSH-major] Breast Neoplasms / pathology. Image Processing, Computer-Assisted. Phyllodes Tumor / pathology

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  • (PMID = 17922594.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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80. Hsu SD, Chou SJ, Hsieh HF, Chen TW, Cheng MF, Yu JC: Giant malignant mammary phyllodes tumor: report of a case and review of the literature. Onkologie; 2007 Feb;30(1-2):45-7
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  • [Title] Giant malignant mammary phyllodes tumor: report of a case and review of the literature.
  • BACKGROUND: To distinguish between a benign and malignant phyllodes tumor before surgery is difficult.
  • Wide excision or mastectomy with adequate free margins is necessary in the case of a malignant phyllodes tumor.
  • However, repairing the skin defect after removal of a giant malignant phyllodes tumor is a great challenge for the breast surgeon.
  • CASE REPORT: We report the case of a 45-year-old Taiwanese woman with a giant malignant phyllodes tumor measuring 30 x 25 x 22 cm.
  • CONCLUSION: Giant malignant phyllodes tumors can be treated by total mastectomy with adequate free margins, using a flap technique to cover the skin defect.
  • [MeSH-major] Breast Neoplasms / diagnosis. Breast Neoplasms / surgery. Mastectomy, Simple / methods. Phyllodes Tumor / diagnosis. Phyllodes Tumor / surgery. Surgical Flaps

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  • (PMID = 17264525.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 7
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81. Wang ZC, Buraimoh A, Iglehart JD, Richardson AL: Genome-wide analysis for loss of heterozygosity in primary and recurrent phyllodes tumor and fibroadenoma of breast using single nucleotide polymorphism arrays. Breast Cancer Res Treat; 2006 Jun;97(3):301-9
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  • [Title] Genome-wide analysis for loss of heterozygosity in primary and recurrent phyllodes tumor and fibroadenoma of breast using single nucleotide polymorphism arrays.
  • Phyllodes tumors of the breast are biphasic stromal and epithelial tumors histologically similar to benign fibroadenomas, but with a neoplastic stromal component.
  • In contrast to fibroadenoma, phyllodes tumors can recur and be locally aggressive or be malignant.
  • This study uses SNP array analysis to present a genome-wide map of loss of heterozygosity (LOH) in a cohort of phyllodes tumors and fibroadenomas.
  • LOH is frequent and sometimes extensive in phyllodes tumors, but is rarely seen in fibroadenomas.
  • There is heterogeneity between phyllodes tumors of different patients and no one LOH marker identifies a majority of these lesions.
  • However, a subset of LOH loci occur in multiple cases of phyllodes tumors and are not found in fibroadenomas.
  • Primary phyllodes tumors and paired recurrences from the same patient share common regions of LOH.
  • Specific LOH loci may be associated with pathologic progression in recurrent phyllodes tumors.
  • In a single case of phyllodes tumor containing a malignant epithelial component the malignant epithelium and stroma partially share an LOH genotype, suggesting a common precursor cell for the biphasic malignant components.
  • [MeSH-major] Breast Neoplasms / genetics. Fibroadenoma / genetics. Loss of Heterozygosity. Neoplasms, Multiple Primary / genetics. Neoplasms, Second Primary / genetics. Oligonucleotide Array Sequence Analysis. Phyllodes Tumor / genetics. Polymorphism, Single Nucleotide
  • [MeSH-minor] Cell Transformation, Neoplastic / genetics. DNA, Neoplasm / genetics. Epithelial Cells / pathology. Female. Gene Expression Profiling. Genome, Human. Humans. Stromal Cells / pathology

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  • (PMID = 16791486.001).
  • [ISSN] 0167-6806
  • [Journal-full-title] Breast cancer research and treatment
  • [ISO-abbreviation] Breast Cancer Res. Treat.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / NCI P50 CA89393-01
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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82. Gobbi D, Dall'Igna P, Alaggio R, Nitti D, Cecchetto G: Giant fibroadenoma of the breast in adolescents: report of 2 cases. J Pediatr Surg; 2009 Feb;44(2):e39-41
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  • [Title] Giant fibroadenoma of the breast in adolescents: report of 2 cases.
  • Giant fibroadenoma (GF) is an uncommon variant of fibroadenomas that represent the most frequent breast lesion in adolescents and young women.
  • Giant fibroadenomas are benign tumors, but their rapid growth and large size together with their rarity may determine difficulties in the clinical approach.
  • Moreover, GF must be excised in all cases to exclude a phyllodes tumor and to prevent later deformity.
  • [MeSH-major] Breast Neoplasms. Fibroadenoma

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  • (PMID = 19231520.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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83. Beier JP, Jaeger K, Horch RE: Reduction mammaplasty for benign phyllodes tumour in an adolescent female--a 13-year follow up. Breast; 2006 Aug;15(4):550-3
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  • [Title] Reduction mammaplasty for benign phyllodes tumour in an adolescent female--a 13-year follow up.
  • Phyllodes tumours are rare neoplasms of the female breast, especially among adolescent women.
  • We present the case of a 17-year old female patient with a large benign phyllodes tumour.
  • Standard plastic surgical techniques like reduction mammaplasty might be applied in treating large benign tumours compromising the aesthetic aspect of the breast.
  • [MeSH-major] Breast Neoplasms / surgery. Mammaplasty. Phyllodes Tumor / surgery

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  • (PMID = 16310356.001).
  • [ISSN] 0960-9776
  • [Journal-full-title] Breast (Edinburgh, Scotland)
  • [ISO-abbreviation] Breast
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Cosmetics
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84. Fernández-Aguilar S, Noël JC: [Malignant phyllodes tumor of the breast with osteoclast-like giant cells: a case report]. Ann Pathol; 2007 Feb;27(1):31-4
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  • [Title] [Malignant phyllodes tumor of the breast with osteoclast-like giant cells: a case report].
  • We report here the first case of a malignant phyllodes tumor associated with OLGC occurring in a 43 year-old African woman who presented with a painful palpable mass of the outer upper quadrant of the right breast.
  • After surgical excision, histological examination showed a malignant phyllodes tumor in which the stromal component displayed evident sarcomatous changes and was densely populated with benign multinucleated OLGC.
  • This lesion ressembles giant cell tumor of bone.
  • [MeSH-major] Breast Neoplasms / pathology. Giant Cells / pathology. Osteoclasts / pathology. Phyllodes Tumor / pathology

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  • (PMID = 17568357.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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85. Kinkor Z, Skálová A, Michal M, Janousek M, Kheck M: [Metastasing and relapsing "low grade" adenosquamous metaplastic breast cancer--is there a really indolent lesion? A description of three cases and review of literature]. Ceska Gynekol; 2005 May;70(3):211-6
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  • RESULTS: Partial mastectomy and segmentectomy were performed in three women 46, 72 and 74 years-old resp. for tumor, which size ranged from 20-35 mm in maximum diameter (mean 28 mm).
  • There were recognized metastases by one woman in two ipsilateral axillary lymph nodes mimicking benign breast heterotopia in one of them.
  • In two women with aggressive course the original biopsy was falsely interpreted, once as phyllodes tumor and secondly as benign sclerosing pseudotumor.
  • Low-grade adenosquamous carcinoma, however, has nothing to do with syringomatous adenoma of the nipple, which is a benign tumor of the skin adnexa.
  • Differential diagnosis includes spectrum of non-neoplastic slerosing lesions and above-mentioned phylloid tumor.
  • The rarity of this neoplasm does not exclude deep knowledge.


86. Turbiner J, Amin MB, Humphrey PA, Srigley JR, De Leval L, Radhakrishnan A, Oliva E: Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term. Am J Surg Pathol; 2007 Apr;31(4):489-500
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  • [Title] Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term.
  • Cystic nephroma (CN) and mixed epithelial and stromal tumor (MEST) are rare benign renal neoplasms that have overlapping clinical and morphologic features, including predominance in middle-aged women, variably cystic architecture, eosinophilic cells, and hobnail cells lining the cysts and ovarian-type stroma.
  • In the epithelial component, the relative amount of large cysts, medium to small cysts, and phyllodes-type glands was: 65%/25%/10% in CNs versus 25%/40%/35% in MESTs.
  • Follow-up in both categories of tumors (mean 3.2 y, median 3 y for CNs and mean 2.5 y, median of 2 y for MESTs) showed no evidence of recurrence or metastases in keeping with their benign nature.
  • This study highlights the remarkable similarity between CN and MEST in sex predilection, age distribution, and morphologic attributes of both the epithelial and stromal components and immunohistochemical profile albeit with variation in individual categories with higher prevalence of stromal to epithelial ratio, prominent ovarian stroma, smaller cysts with phyllodes glands pattern and stromal luteinization being more common in MEST; and large cysts, thin septae and low stromal to epithelial ratio in CN.
  • On the basis of detailed morphologic analysis of this series of CN and MEST, we propose a unifying term of "renal epithelial and stromal tumor" (REST) to encompass the spectrum of findings observed in these tumors at least until new molecular studies can prove or disprove this challenging hypothesis.

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  • (PMID = 17414095.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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87. Huo L, Gilcrease MZ: Fibroepithelial lesions of the breast with pleomorphic stromal giant cells: a clinicopathologic study of 4 cases and review of the literature. Ann Diagn Pathol; 2009 Aug;13(4):226-32
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  • In this report, we describe 4 fibroadenoma-like lesions of the breast with pleomorphic stromal giant cells.
  • Two cases had focal stromal hypercellularity, one of which was with architectural features borderline between a fibroadenoma and a phyllodes tumor, but none was considered diagnostic of phyllodes tumor.
  • Follow-up for 3 cases at 16 to 59 months revealed no evidence of tumor recurrence.
  • It appears that the presence of pleomorphic stromal giant cells in an otherwise benign fibroepithelial lesion has no adverse clinical significance.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Fibroadenoma / diagnosis. Fibroadenoma / pathology. Humans. Middle Aged. Mitosis. Phyllodes Tumor / diagnosis. Phyllodes Tumor / pathology

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  • (PMID = 19608080.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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88. Kim JH, Choi YD, Lee JS, Lee JH, Nam JH, Choi C, Park MH, Yoon JH: Borderline and malignant phyllodes tumors display similar promoter methylation profiles. Virchows Arch; 2009 Dec;455(6):469-75
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  • [Title] Borderline and malignant phyllodes tumors display similar promoter methylation profiles.
  • Mammary phyllodes tumors (PTs) are uncommon fibroepithelial neoplasms.
  • On the basis of histologic criteria, PTs can be divided into benign, borderline, and malignant groups; however, the histologic distinction of PTs is often difficult and arbitrary.
  • A multiplex, nested, methylation-specific polymerase chain reaction approach was used to examine promoter methylation of five genes (GSTP1, HIN-1, RAR-beta, RASSF1A, and Twist) in 87 PTs (54 benign, 23 borderline, and 10 malignant).
  • The methylation frequency of all genes and the mean number of methylated genes in borderline and malignant PTs were higher than those in benign PTs; however, there were no statistically significant differences between borderline and malignant PTs.
  • These results suggest that PTs segregate into only two groups on the basis of their methylation profiles: the benign group and the combined borderline/malignant group.
  • [MeSH-major] Breast Neoplasms / genetics. DNA Methylation. Phyllodes Tumor / genetics. Precancerous Conditions / genetics. Promoter Regions, Genetic / genetics
  • [MeSH-minor] Adult. Biomarkers, Tumor / genetics. Cytokines / genetics. Cytokines / metabolism. Female. Gene Expression Regulation, Neoplastic. Glutathione S-Transferase pi / genetics. Glutathione S-Transferase pi / metabolism. Humans. Nuclear Proteins / genetics. Nuclear Proteins / metabolism. Polymerase Chain Reaction. Receptors, Retinoic Acid / genetics. Receptors, Retinoic Acid / metabolism. Tumor Suppressor Proteins / genetics. Tumor Suppressor Proteins / metabolism. Twist-Related Protein 1 / genetics. Twist-Related Protein 1 / metabolism

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  • (PMID = 19924440.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cytokines; 0 / Nuclear Proteins; 0 / RASSF1 protein, human; 0 / Receptors, Retinoic Acid; 0 / SCGB3A1 protein, human; 0 / TWIST1 protein, human; 0 / Tumor Suppressor Proteins; 0 / Twist-Related Protein 1; 0 / retinoic acid receptor beta; EC 2.5.1.18 / GSTP1 protein, human; EC 2.5.1.18 / Glutathione S-Transferase pi
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89. Herawi M, Epstein JI: Specialized stromal tumors of the prostate: a clinicopathologic study of 50 cases. Am J Surg Pathol; 2006 Jun;30(6):694-704
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  • The histology in the 36 cases of STUMP not associated with sarcoma were as follows: 25 composed of stroma with scattered cytologically atypical cells associated with benign glands; 8 resembling glandular-stromal hyperplasia but with hypercellular stroma; 6 with extensive myxoid stroma; and 1 with phyllodes pattern.
  • Five cases of STUMP showed local tumor growth: 1 case increased in size from 6 to 7.5 cm in 3 years and 4 cases recurred frequently necessitating multiple TURs of the prostate (n=2, n=3, n=3, n=3) over 1.1, 2, 7, and 8 years, respectively.
  • Fourteen patients with STUMP underwent radical prostatectomy (RP) soon after diagnosis; of these, 12 were organ confined where the tumor size ranged from 0.7 to 7.5 cm (mean 2.7 cm); 2 cases with a history of a 28 g TUR and a 275 g enucleation showed no residual tumor in the RP specimen.

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  • (PMID = 16723846.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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90. Anyikam A, Nzegwu MA, Ozumba BC, Okoye I, Olusina DB: Benign breast lesions in Eastern Nigeria. Saudi Med J; 2008 Feb;29(2):241-4
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  • [Title] Benign breast lesions in Eastern Nigeria.
  • OBJECTIVE: To characterize benign breast diseases in Eastern Nigeria and to highlight the age variations of these lesions as base line data.
  • Seven hundred and twenty-two benign breast specimens were analyzed over 5 years from 1st January 2000 to 31st December 2004, out of 1050 breast samples received.
  • RESULTS: Of 1050 breast specimens received, 722 (68.8%) were benign.
  • Fibroadenoma was the most common lesion with 318 cases (44%), occurring at a mean age of 16-32 years.
  • Low grade Phyllodes tumor had 28 cases (3.9%), presenting at an average mean age of 17-32 years.
  • Benign breast lesions peaked at the 20-24 age range and then declined.
  • CONCLUSION: Benign breast lesions occur more frequently than malignant breast lesions with a ratio of 2.3:1 and were presented 20 years earlier than their malignant counterparts.
  • Fibroadenoma was the most common benign lesion followed by fibrocystic disease, similar to the findings in Western Nigeria.
  • [MeSH-major] Breast Diseases / epidemiology. Breast Neoplasms / epidemiology. Fibroadenoma / epidemiology
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Child. Female. Fibrocystic Breast Disease / epidemiology. Gynecomastia / epidemiology. Humans. Male. Middle Aged. Nigeria / epidemiology. Phyllodes Tumor / epidemiology. Sex Factors

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  • (PMID = 18246234.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Saudi Arabia
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91. Fajdić J, Gotovac N, Hrgović Z, Kristek J, Horvat V, Kaufmann M: Phyllodes tumors of the breast diagnostic and therapeutic dilemmas. Onkologie; 2007 Mar;30(3):113-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phyllodes tumors of the breast diagnostic and therapeutic dilemmas.
  • BACKGROUND: This article compares experiences in the diagnosis and treatment of phyllodes tumors from 2 regional institutions with the relevant literature.
  • PATIENTS AND METHODS: From 1991 to 2005, 2,848 breast cancer patients were treated in our institutions, 36 (1.44%) for phyllodes tumors.
  • The average tumor size was 5.1 cm (range 1.4-19.6).
  • Wide excision with tumor-free margins was carried out in 29 (80.5%) cases and mastectomy in 7 (19.4%) cases.
  • RESULTS: Histology showed the phyllodes tumors to be benign in 27 (75.0%), malignant in 6 (16.6%), and borderline in 3 (8.3%) cases.
  • In this period, recurrences of 3 (8.3%) malignant and 2 (5.6%) benign phyllodes tumors were diagnosed and treated.
  • CONCLUSION: Our study shows that tumor size, margin infiltration, mitotic activity and degree of cellular atypia are important prognostic factors.
  • Problems in diagnosing this condition arise from its similarity to fibroadenoma.
  • Although wide local excision is usually the treatment of choice, tumor recurrence is common.
  • Axillary lymphadenectomy in malignant phyllodes tumors is, in our opinion, still controversial.
  • [MeSH-major] Breast Neoplasms / diagnosis. Phyllodes Tumor / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Breast / pathology. Diagnosis, Differential. Female. Humans. Lymph Node Excision. Lymph Nodes / pathology. Lymphatic Metastasis / pathology. Mammography. Mastectomy. Mastectomy, Segmental. Middle Aged. Mitotic Index. Necrosis. Neoplasm Invasiveness / pathology. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Prognosis. Reoperation. Survival Rate

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  • (PMID = 17341897.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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92. McCluggage WG: Mullerian adenosarcoma of the female genital tract. Adv Anat Pathol; 2010 Mar;17(2):122-9
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  • Mullerian adenosarcoma is an uncommon, but not rare, mixed tumor containing a neoplastic but benign or mildly atypical epithelial element and a sarcomatous, usually low-grade, stromal component.
  • Characteristic histologic features include a low power "phyllodes-like" architecture with leaf-like projections lined by a variety of benign Mullerian type epithelia, sometimes with squamous metaplasia.
  • Adenosarcoma may be confused with a variety of lesions and one of the main differential diagnoses is adenofibroma in which the stromal component is, by definition, morphologically benign.

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  • (PMID = 20179434.001).
  • [ISSN] 1533-4031
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 39
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93. Kamate B, Traore CB, Diallo D, Foko I, Sangare F, Malle B, Coulibaly B, Mounkoro N, Bayo S: [Epidemiology and morphology of breast benign tumors in Mali: about 186 cases]. Mali Med; 2008;23(3):36-9
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  • [Title] [Epidemiology and morphology of breast benign tumors in Mali: about 186 cases].
  • Benign tumors are more frequent, and are characterized by a possibility of recurrence or malignant transformation.
  • The aim of this study was to describe the epidemiological and morphological characteristics of breast benign tumors.
  • The study had concerned all benign tumors confirmed by histology.
  • FINDINGS: In total, 186 benign tumors were diagnosed over 611 mammary pathologies (30.44%).
  • Tumor sizes were variable, and the color changed through white to yellow.
  • Histological aspects were: fibroadenoma (72%), lipoma (8.6%), tubular adenoma (5.9%), papilloma (5.4%), lactating adenoma (3.8%), phyllodes tumor (3.8%), and syringomatous tumor (0.5%).
  • CONCLUSION: Benign tumors are frequent in mammary pathology.

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  • (PMID = 19617151.001).
  • [ISSN] 1993-0836
  • [Journal-full-title] Le Mali médical
  • [ISO-abbreviation] Mali Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mali
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94. de León DC, Montiel DP, Nemcova J, Mykyskova I, Turcios E, Villavicencio V, Cetina L, Coronel A, Hes O: Human papillomavirus (HPV) in breast tumors: prevalence in a group of Mexican patients. BMC Cancer; 2009;9:26
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Fifty-one cases of breast cancer were selected from the files of the institute and compared by age and tumor size with 43 cases of non malignant breast lesions (fibroadenoma, fibrocystic disease and phyllodes tumor).
  • RESULTS: All patients were mexican, mean age was 53.3, median age of menarche was 13 and median tumor size 9 cms.
  • In the group of benign conditions all were negative to HPV-DNA.

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  • [Cites] Breast. 2007 Apr;16(2):172-7 [17088061.001]
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  • (PMID = 19161629.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Viral
  • [Other-IDs] NLM/ PMC2636825
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95. Bhargav PR, Mishra A, Agarwal G, Agarwal A, Verma AK, Mishra SK: Phyllodes tumour of the breast: clinicopathological analysis of recurrent vs. non-recurrent cases. Asian J Surg; 2009 Oct;32(4):224-8
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  • [Title] Phyllodes tumour of the breast: clinicopathological analysis of recurrent vs. non-recurrent cases.
  • BACKGROUND: The aim of this study was to present our experience of dealing with patients with phyllodes tumours (PT) and to correlate the risk of local recurrence with different clinicopathological factors.
  • The mean tumour diameter was 10.5 +/- 5 cm.
  • The histology report was benign, borderline and malignant PT in 28%, 20% and 52% of cases respectively.

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  • (PMID = 19892625.001).
  • [ISSN] 0219-3108
  • [Journal-full-title] Asian journal of surgery
  • [ISO-abbreviation] Asian J Surg
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] China
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96. Yoo JL, Woo OH, Kim YK, Cho KR, Yong HS, Seo BK, Kim A, Kang EY: Can MR Imaging contribute in characterizing well-circumscribed breast carcinomas? Radiographics; 2010 Oct;30(6):1689-702
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Most well-circumscribed breast masses are benign lesions such as cysts, fibroadenomas, and intramammary lymph nodes.
  • Nevertheless, 10%-20% of breast malignancies are well-circumscribed masses, and these malignancies include papillary, mucinous, medullary, and metaplastic carcinomas, as well as malignant phyllodes tumors.
  • Therefore, it is important to differentiate these well-circumscribed breast malignancies from benign breast lesions, but it is not easy to do so with conventional imaging modalities such as mammography and ultrasonography (US).
  • Analysis of the lesion signal intensity on nonenhanced T2-weighted MR images, determination of the enhancement pattern, and kinetic curve assessment can greatly help differentiate malignant from benign well-circumscribed breast lesions.
  • Therefore, breast MR imaging can play a substantial role in distinguishing between well-circumscribed benign and malignant breast lesions, especially in cases that are difficult to diagnose by using conventional imaging.
  • In this article, the MR imaging findings of the subtypes of well-circumscribed malignant breast lesions-intracystic papillary carcinoma, invasive papillary carcinoma, mucinous carcinoma, medullary carcinoma, metaplastic carcinoma, and malignant phyllodes tumor-are described and correlated with the histopathologic, mammographic, and US findings.
  • [MeSH-minor] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / pathology. Carcinoma, Medullary / diagnosis. Carcinoma, Medullary / pathology. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / pathology. Contrast Media. Diagnosis, Differential. Female. Humans. Neoplasm Invasiveness. Phyllodes Tumor / diagnosis. Phyllodes Tumor / pathology

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  • [Copyright] © RSNA, 2010.
  • [CommentIn] Radiographics. 2010 Oct;30(6):1703-4; discussion 1704 [21117281.001]
  • (PMID = 21071383.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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97. Chen WH, Cheng SP, Tzen CY, Yang TL, Jeng KS, Liu CL, Liu TP: Surgical treatment of phyllodes tumors of the breast: retrospective review of 172 cases. J Surg Oncol; 2005 Sep 1;91(3):185-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of phyllodes tumors of the breast: retrospective review of 172 cases.
  • BACKGROUND AND OBJECTIVES: Phyllodes tumors (PTs) are uncommon biphasic breast tumors that usually occur in adult females.
  • They are composed of a benign epithelial component and a cellular, spindle cell stroma forming a leaf-like structure.
  • No one morphologic finding is reliable in predicting the clinical behavior of the tumor.
  • Clinical data analyzed included age, presenting symptoms and signs, tumor size, location, type of surgery, time to recurrence, and metastasis.
  • The pathologic diagnoses included 131 benign, 12 borderline, and 29 malignant lesions.
  • The initial diagnosis of all 19 recurrent tumors were benign.
  • Stromal cellularity, stromal overgrowth, stromal atypia, mitotic activity, tumor margin, and heterologous stromal elements were significantly correlated with metastases (P = 0.032, 0.00008, 0.000002, 0.004, 0.005, and 0.046, respectively).
  • Fifteen patients in our series had tumors with infiltrating tumor margin, severe stromal overgrowth, atypia, and cellularity.
  • Patients have tumors with infiltrating tumor margin, severe stromal overgrowth, atypia, and cellularity are at high risk for metastases.
  • [MeSH-major] Breast Neoplasms / surgery. Mastectomy / methods. Phyllodes Tumor / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Mastectomy, Segmental. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local / epidemiology. Retrospective Studies. Taiwan / epidemiology. Treatment Outcome

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 16118768.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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98. Manfrin E, Mariotto R, Remo A, Reghellin D, Falsirollo F, Dalfior D, Bricolo P, Piazzola E, Bonetti F: Benign breast lesions at risk of developing cancer--a challenging problem in breast cancer screening programs: five years' experience of the Breast Cancer Screening Program in Verona (1999-2004). Cancer; 2009 Feb 1;115(3):499-507
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  • [Title] Benign breast lesions at risk of developing cancer--a challenging problem in breast cancer screening programs: five years' experience of the Breast Cancer Screening Program in Verona (1999-2004).
  • BACKGROUND: Cytology and core-needle biopsies are not always sufficient to exclude malignancy in benign breast lesions (BBL) that are at risk of developing cancer, and open biopsy often is mandatory.
  • In screening programs, open biopsies performed for lesions that are at risk of developing malignancy are considered benign.
  • The authors of this report evaluated the impact of the screen-detected BBL at risk of developing cancer that were counted in the quota of benign breast open biopsies in the Breast Cancer Screening Program of Verona.
  • METHODS: Benign open biopsies were subdivided into 4 groups according to their risk of developing cancer: Histo1, normal histology; Histo2, 'pure' BBL (fibroadenoma, fibrocystic disease, mastitis, adenosis); Histo3, BBL with a low risk of developing cancer (radial scar, papilloma, papillomatosis, phyllodes tumor, mucocele-like lesion); and Histo4, BBL with a high risk of developing cancer (atypical columnar cell hyperplasia, atypical ductal hyperplasia, atypical lobular hyperplasia).
  • RESULTS: Of 510 open biopsies, 83 biopsies were benign, and the ratio of benign to malignant biopsies was 1:5.
  • Histo1 was observed in 4.8% of all benign open biopsies, Histo2 was observed in 37.4%, Histo3 was observed in 31.3%, and Histo4 was observed 26.5%.
  • It is inappropriate to include BBL at risk of developing cancer in the overall benign open biopsy rate.


99. Tan PH, Jayabaskar T, Yip G, Tan Y, Hilmy M, Selvarajan S, Bay BH: p53 and c-kit (CD117) protein expression as prognostic indicators in breast phyllodes tumors: a tissue microarray study. Mod Pathol; 2005 Dec;18(12):1527-34
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  • [Title] p53 and c-kit (CD117) protein expression as prognostic indicators in breast phyllodes tumors: a tissue microarray study.
  • Breast phyllodes tumors are fibroepithelial neoplasms whose clinical behavior is difficult to predict on histology.
  • In this study, we determined if p53 and CD117 (c-kit) protein expression was predictive of behavior in a series of 335 phyllodes tumors diagnosed at the Singapore General Hospital, using immunohistochemistry on tissue microarrays.
  • Representative areas from 250 (75%) benign, 54 (16%) borderline and 31 (9%) malignant phyllodes tumors were selected for construction of tissue microarrays using the 2 mm punch.
  • Stromal p53 and CD117 protein expression was associated with tumor grade (P < 0.05).
  • We conclude that tissue microarrays are a convenient method for evaluating immunostaining results of large numbers of phyllodes tumors.
  • Although positive p53 stromal immunohistochemical detection may corroborate histologic malignancy, it is CD117 protein expression in phyllodes tumor stromal cells that may be of potential utility in predicting recurrent disease.
  • [MeSH-major] Breast Neoplasms / diagnosis. Phyllodes Tumor / diagnosis. Proto-Oncogene Proteins c-kit / metabolism. Tissue Array Analysis / methods. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Female. Humans. Immunohistochemistry. Middle Aged. Neoplasm Recurrence, Local. Prognosis

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  • (PMID = 16258510.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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100. Roa JC, Tapia O, Carrasco P, Contreras E, Araya JC, Muñoz S, Roa I: Prognostic factors of phyllodes tumor of the breast. Pathol Int; 2006 Jun;56(6):309-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic factors of phyllodes tumor of the breast.
  • The phyllodes tumor is characterized by its tendency to recur locally and occasionally to metastasize.
  • The purpose of the present paper was to assess the prognostic value of clinical-morphological characteristics in patients with phyllodes tumor.
  • Forty-seven cases of phyllodes tumors was studied; the World Health Organization classification was used and follow up was obtained.
  • A total of 51%, 28% and 21% of the tumors were classified as benign, borderline and malignant, respectively.
  • The adherence (P = 0.01), size >10 cm (P = 0.001), high mitotic activity (P = 0.03), infiltrative tumor margin (P = 0.0002) and type of surgery in malignant tumors (P = 0.02) proved to be good predictors of relapse.
  • Tumoral grade and some clinical-morphological characteristics of patients with phyllodes tumors have a significant impact on the prediction of its biological behavior.
  • [MeSH-major] Breast Neoplasms / diagnosis. Phyllodes Tumor / diagnosis

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  • (PMID = 16704494.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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