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1. Basu S, Houseni M, Alavi A: Significance of incidental fluorodeoxyglucose uptake in the parotid glands and its impact on patient management. Nucl Med Commun; 2008 Apr;29(4):367-73
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  • [Title] Significance of incidental fluorodeoxyglucose uptake in the parotid glands and its impact on patient management.
  • BACKGROUND AND OBJECTIVES: Minimal-to-low grade fluorodeoxyglucose (FDG) uptake in the parotid glands is regarded as a normal variant in a whole-body survey with FDG-PET.
  • Not frequently, however, a relatively intense or asymmetric FDG uptake is encountered in the parotid glands.
  • The aim of this study was to determine the causes and characteristics of this 'FDG accumulation of uncertain significance' in the parotid glands in patients without any known or suspected pathologies at the time of whole-body FDG-PET.
  • In addition, we also examined patients in whom there was no documented evidence of parotid pathology before FDG-PET scan and a suspicion of disease involvement was first raised in the reports in view of focal uptake in the FDG-PET images.
  • Only those cases with no earlier history of disease involvement of parotid gland or known parotid pathology before FDG-PET were selected for this analysis.
  • These patients were selected from a population of patients with a known malignancy elsewhere who underwent conventional whole-body FDG-PET or PET/CT for staging, disease viability assessment, or treatment monitoring purposes and had demonstrated varying patterns of FDG uptake (unilateral, bilateral, symmetric, or asymmetric) in the parotid glands.
  • FDG uptake in the parotid glands was reported to be of uncertain significance in the majority of these patients and further correlation was suggested in the PET reports.
  • The results of appropriate correlative investigations with MRI, low-dose nonenhanced attenuation CT images (based on PET/CT scans), and histopathology (in cases in which focal lesions were revealed by the anatomic imaging modalities and biopsy was performed) carried out subsequent to the FDG-PET scans were reviewed for a definitive conclusion with regard to the significance of the FDG uptake in the parotid glands in these patients.
  • The pattern and the intensity of the FDG uptake were correlated with the final diagnosis.
  • The final diagnosis based upon histopathology revealed primary parotid tumors (e.g., Warthin's tumor and pleomorphic adenoma, which presented as FDG-avid parotid incidentaloma) or metastatic disease involvement.
  • CONCLUSION: Both the pattern and intensity of FDG uptake have important implications for differential diagnosis in the salivary glands in whole-body FDG-PET.
  • [MeSH-major] Fluorodeoxyglucose F18 / pharmacokinetics. Parotid Gland / metabolism. Parotid Gland / radionuclide imaging. Salivary Gland Diseases / metabolism. Salivary Gland Diseases / radionuclide imaging

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  • (PMID = 18317302.001).
  • [ISSN] 0143-3636
  • [Journal-full-title] Nuclear medicine communications
  • [ISO-abbreviation] Nucl Med Commun
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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2. Wang PZ, Yu Q, Shi HM, Luo JC: [Diagnostic value of CT perfusion for parotid gland tumors]. Shanghai Kou Qiang Yi Xue; 2005 Dec;14(6):573-7
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  • [Title] [Diagnostic value of CT perfusion for parotid gland tumors].
  • PURPOSE: The aim of this study was to determine whether CT perfusion was valuable in differentiating benign tumors from malignant ones in the parotid gland.
  • METHODS: Fifty-three parotid gland tumors, 35 benign and 18 malignant, in 51 patients were included in this study.
  • Wilcoxon sign sum test, a nonparameters test for paired data were used to determine the statistical differences of parameters between the benign and malignant tumors.
  • RESULTS: The mean values +/- standard variations of BF, BV, MTT and PS were 139.85+/-175.13, 17.16+/-15.67, 13.27+/-4.42, and 24.38+/-14.52 respectively in benign tumors, versus 231.69+/-205.29, 32.22+/-20.56, 11.40+/-3.95 and 38.28+/-19.00 respectively in malignant tumors.
  • Except for MTT, the differences of BF, BV and PS between benign and malignant tumors were statistically significant (P<0.01).
  • CONCLUSIONS: On the basis of the results of this study, the parameters of CT perfusion, BF, BV and PS, were valuable in differentiating benign and malignant tumors of the parotid gland.
  • [MeSH-major] Parotid Gland / radiography. Parotid Neoplasms / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 16400481.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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3. Gaio E, Marioni G, Ferraro SM, Schwager K: [Infected parotid cyst as a cause of facial palsy]. Laryngorhinootologie; 2006 Jan;85(1):43-5
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  • [Title] [Infected parotid cyst as a cause of facial palsy].
  • In the literature, only 8 cases of facial paralysis associated with parotid cyst have been described.
  • PATIENT AND RESULTS: We present a case of facial palsy caused by an inflamed cyst of the parotid gland.
  • The patient was operated on with the diagnosis malignant parotid tumor.
  • CONCLUSIONS: As a rule the combination parotid gland lesion and facial palsy is a sign of malignancy, clinicians should be aware that, on rare occasions, facial nerve dysfunction may result from benign parotid gland disease.
  • [MeSH-major] Cysts / complications. Facial Paralysis / etiology. Parotid Diseases / complications
  • [MeSH-minor] Aged. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Time Factors

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  • (PMID = 16444655.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
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4. Ono K, Inoue H, Masuda W, Morimoto Y, Tanaka T, Yokota M, Inenaga K: Relationship of chewing-stimulated whole saliva flow rate and salivary gland size. Arch Oral Biol; 2007 May;52(5):427-31
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  • [Title] Relationship of chewing-stimulated whole saliva flow rate and salivary gland size.
  • OBJECTIVE: We have recently reported that unstimulated whole saliva flow rates (UWSFR) correlate positively with salivary gland sizes and body profiles of weight and body mass indices.
  • In the present study, the correlations of chewing-stimulated whole saliva flow rates (CWSFR) with salivary gland sizes and the body profiles were investigated, and the results were compared with those of UWSFR.
  • The CWSFRs in all subjects correlated positively with parotid and/or submandibular gland sizes, weights and body mass indices, just as with UWSFR; however, the correlation coefficients with salivary gland sizes were smaller than those of UWSFR.
  • In contrast to the results of UWSFR, the correlation coefficients of the CWSFRs with parotid gland sizes in all subjects were larger than those with the sizes of the submandibular glands.
  • The CWSFRs in males correlated only with parotid gland sizes, and those in females did not correlate with any of the parameters.
  • [MeSH-minor] Adult. Body Mass Index. Body Weight / physiology. Female. Humans. Male. Menstrual Cycle / physiology. Parotid Gland / anatomy & histology. Secretory Rate / physiology. Sex Factors. Submandibular Gland / anatomy & histology

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  • (PMID = 17126285.001).
  • [ISSN] 0003-9969
  • [Journal-full-title] Archives of oral biology
  • [ISO-abbreviation] Arch. Oral Biol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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5. Emodi O, El-Naaj IA, Gordin A, Akrish S, Peled M: Superficial parotidectomy versus retrograde partial superficial parotidectomy in treating benign salivary gland tumor (pleomorphic adenoma). J Oral Maxillofac Surg; 2010 Sep;68(9):2092-8
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  • [Title] Superficial parotidectomy versus retrograde partial superficial parotidectomy in treating benign salivary gland tumor (pleomorphic adenoma).
  • PURPOSE: Of all benign salivary gland tumors of the parotid gland, pleomorphic adenoma (mixed tumor) is the most common.
  • It accounts for 60% to 70% of all benign tumors of the parotid gland.
  • This neoplasm arises in patients in the fourth to sixth decade of life, with a female predominance.
  • PATIENTS AND METHODS: We reviewed 48 patients who underwent excision of pleomorphic adenoma of the parotid gland between 1996 and 2005 at Rambam Medical Center: 18 were treated surgically with the classical superficial parotidectomy (SP) technique, using an anterograde approach, and 30 were treated with retrograde partial superficial parotidectomy (PSP).
  • We compared the 2 surgical techniques in terms of surgical time, histopathologic size of the lesion, amount of excised healthy parotid tissue, histologic margin, and the preservation of the capsule/pseudocapsule.
  • Much more healthy parotid tissue was taken out with the classical procedure (mean, 51.4 +/- 13.6 mm; median, 50 mm) than with the retrograde PSP technique (mean, 39.2 +/- 11.8; median, 35 mm) (P = .01).
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Oral Surgical Procedures / methods. Parotid Gland / surgery. Parotid Neoplasms / surgery

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  • [Copyright] Copyright 2010 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20728030.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
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6. Boccon-Gibod L, Boman F, Josset P, Landman-Parker J: Mucoepidermoid carcinoma of the parotid gland in a child previously treated for acute lymphoblastic leukemia. Pediatr Blood Cancer; 2005 Jun 15;44(7):673-5
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  • [Title] Mucoepidermoid carcinoma of the parotid gland in a child previously treated for acute lymphoblastic leukemia.
  • Children treated for acute lymphoblastic leukemia (ALL) have an increased risk for developing mucoepidermoid carcinomas (MEC) of the parotid gland.
  • Low-grade MEC of the left parotid gland was diagnosed at the age of 7 years, only 1 year after completing treatment.
  • This case report is remarkable for the early diagnosis of second cancer, only 4 years after diagnosis of ALL, and its occurrence in parotid gland without previous head and neck irradiation.
  • It highlights the need for concern about second cancers of the parotid gland in children treated for ALL.
  • [MeSH-major] Carcinoma, Mucoepidermoid / etiology. Neoplasms, Second Primary / etiology. Parotid Neoplasms / etiology. Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy

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  • [Copyright] Copyright 2004 Wiley-Liss, Inc.
  • (PMID = 15515042.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 17
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7. Gupta G, Singh R, Shanmugasamy K, Kotasthane DS, Kotasthane VD: Basal cell adenocarcinoma in the tongue: an unusual presentation. Clin Med Insights Oncol; 2010 Nov 21;4:127-31
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  • BCAC generally occurs in the parotid gland and rarely involves the minor salivary glands.
  • Hematoxylin and eosin staining showed tumour composed of variable sized and shaped, nests and sheets of basaloid epithelial cells having hyperchromatic to vesicular nuclei.
  • The clinicopathological features and the cellular immunophenotype addressed the diagnosis towards BCAC of the tongue.
  • The goal of this report is to increase awareness of this rare disease and to review and discuss the differential diagnosis and important considerations in treatment.

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  • (PMID = 21151583.001).
  • [ISSN] 1179-5549
  • [Journal-full-title] Clinical Medicine Insights. Oncology
  • [ISO-abbreviation] Clin Med Insights Oncol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2999957
  • [Keywords] NOTNLM ; basal cell adenocarcinoma / minor salivary gland / tongue
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8. Kaeppler G, Buchgeister M, Reinert S: Influence of the rotation centre in panoramic radiography. Radiat Prot Dosimetry; 2008;128(2):239-44
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  • The curves of the rotation centre showed clear differences especially in the area of the parotid gland.
  • [MeSH-minor] Humans. Neck / radiation effects. Parotid Gland / radiation effects. Phantoms, Imaging. Pituitary Gland / radiation effects. Rotation

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  • (PMID = 17573368.001).
  • [ISSN] 0144-8420
  • [Journal-full-title] Radiation protection dosimetry
  • [ISO-abbreviation] Radiat Prot Dosimetry
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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9. Chung SW, Kwon SY, Jung KY, Woo JS: Synchronous double primary cancers of the unilateral parotid gland. Acta Otolaryngol; 2007 Feb;127(2):209-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous double primary cancers of the unilateral parotid gland.
  • Synchronous parotid neoplasms, especially synchronous neoplasms of two separate and histologically different types, are extremely uncommon.
  • A review of the literature revealed that most reported cases were either a combination of two distinct benign neoplasms or a benign neoplasm and another malignant tumor.
  • To the best of our knowledge, there has been no report of synchronous unilateral double primary carcinomas of the parotid gland.
  • Here we report a 39-year-old woman who exhibited basal cell adenocarcinoma and mucoepidermoid carcinoma simultaneously in the left parotid gland.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Mucoepidermoid / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology

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  • (PMID = 17364354.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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10. Busch L, Sterin-Borda L, Borda E: Effects of castration on cannabinoid cb receptor expression and on the biological actions of cannabinoid in the parotid gland. Clin Exp Pharmacol Physiol; 2006 Mar;33(3):258-63
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  • [Title] Effects of castration on cannabinoid cb receptor expression and on the biological actions of cannabinoid in the parotid gland.
  • In the present study, we examined whether cannabinoid receptor expression and the effects of receptor stimulation vary as a function of gonadal status in a peripheral tissue, namely the male rat parotid gland.
  • 7. It can be concluded that CB(1) cannabinoid receptor expression is regulated by testosterone in male rat parotid gland and this has functional implications for cAMP accumulation and amylase release.
  • [MeSH-major] Cannabinoids / pharmacology. Orchiectomy. Parotid Gland / drug effects. Receptor, Cannabinoid, CB1 / biosynthesis

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  • (PMID = 16487271.001).
  • [ISSN] 0305-1870
  • [Journal-full-title] Clinical and experimental pharmacology & physiology
  • [ISO-abbreviation] Clin. Exp. Pharmacol. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Arachidonic Acids; 0 / Cannabinoids; 0 / Endocannabinoids; 0 / Ligands; 0 / Piperidines; 0 / Polyunsaturated Alkamides; 0 / Proteins; 0 / Pyrazoles; 0 / Receptor, Cannabinoid, CB1; 158681-13-1 / rimonabant; 3XMK78S47O / Testosterone; 94421-68-8 / anandamide; E0399OZS9N / Cyclic AMP; EC 3.2.1.- / Amylases; EC 3.6.1.- / Adenosine Triphosphatases; EC 3.6.3.9 / Sodium-Potassium-Exchanging ATPase; EC 4.6.1.1 / Adenylyl Cyclases
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11. Masuda M, Segawa Y, Joe AK, Hirakawa N, Komune S: A case of primary Hodgkin's lymphoma of the parotid gland. Auris Nasus Larynx; 2008 Sep;35(3):440-2
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  • [Title] A case of primary Hodgkin's lymphoma of the parotid gland.
  • We report an extremely rare case (sixth reported case) of primary Hodgkin's lymphoma (HL) (mixed cellularity type) of the parotid gland.
  • A 14-year-old man was referred to our hospital for evaluation of a parotid mass.
  • Although the initial aspiration cytology was highly suggestive of HL, the confirmatory diagnosis obtained by open biopsy was non-specific lymphadenitis.
  • Because the mass continued to increase in size, we performed a total parotidectomy which led to the diagnosis of mixed cellularity HL.
  • This case suggests that the specimen taken during open biopsy may have been too small (about 1 cm3) to detect the presence of Reed-Sternberg giant cells, which is essential for the diagnosis of HL.
  • Therefore, although primary HL of the parotid gland is extremely rare, adequate tissue sampling of a clinically suspicious parotid mass will be required for the diagnosis of HL.
  • [MeSH-major] Hodgkin Disease / diagnosis. Parotid Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy, Fine-Needle. Chemotherapy, Adjuvant. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Neoplasm Staging. Parotid Gland / pathology. Parotid Gland / surgery. Radiotherapy, Adjuvant. Tomography, X-Ray Computed

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  • (PMID = 17983719.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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12. Vaudaux JD, Moulin AP, Olivier F, Guex-Crosier Y: Parotid gland fine-needle aspiration biopsy in the diagnosis of ocular sarcoidosis. Klin Monbl Augenheilkd; 2010 Apr;227(4):328-9
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  • [Title] Parotid gland fine-needle aspiration biopsy in the diagnosis of ocular sarcoidosis.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Eye Diseases / pathology. Parotid Gland / pathology. Sarcoidosis / pathology

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  • (PMID = 20408089.001).
  • [ISSN] 1439-3999
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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13. Wang Z, Wu H, Huang Q, Cao R, Chen X, Yang J, Xiang M: [Facial nerve monitoring in parotid gland surgery]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2006 May;20(10):436-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Facial nerve monitoring in parotid gland surgery].
  • OBJECTIVE: To investigate the use and effect of facial nerve monitoring in parotid gland surgery.
  • METHOD: Twenty-two patients with benign parotid tumor who received parotidectomy with continuous monitoring of the facial nerve were selected to analyse.
  • RESULT: Each patient had a total resection of tumor without facial nerve paresis or sialocele formation.
  • CONCLUSION: Facial nerve monitoring is a useful tool in parotid gland surgery.
  • [MeSH-major] Facial Nerve / physiology. Monitoring, Intraoperative. Parotid Gland / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Electromyography. Facial Paralysis / prevention & control. Female. Humans. Male. Middle Aged. Parotid Neoplasms / surgery. Retrospective Studies. Young Adult

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  • (PMID = 16883785.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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14. Doğan S, Can IH, Unlü I, Süngü N, Gönültaş MA, Samim EE: Sialolipoma of the parotid gland. J Craniofac Surg; 2009 May;20(3):847-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sialolipoma of the parotid gland.
  • A 33-year-old male patient with a slow-growing, painless, well-circumscribed soft tissue mass on the left parotid region is presented.
  • The clinical impression was that of a benign salivary gland tumor.
  • The tumor was situated in the superficial lobe of the gland, and a superficial parotidectomy was performed, with preservation of the facial nerve.
  • Histopathologic examination results revealed a sialolipoma of the parotid gland and a lesion that consisted of both mature adipose tissue and glandular elements.
  • Preoperative diagnosis is generally difficult, and computed tomographic scanning is useful in defining these benign parotid gland masses.
  • Superficial parotidectomy is the usual surgical treatment for parotid gland superficial lobe lipomas, with near-total absence of recurrence.
  • [MeSH-major] Lipoma / diagnosis. Parotid Neoplasms / diagnosis
  • [MeSH-minor] Adipose Tissue / pathology. Adult. Diagnosis, Differential. Humans. Male. Parotid Gland / pathology

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  • (PMID = 19390452.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Pietniczka-Załeska M, Kukwa A: [The parotid gland's tumours in material of Otolaryngology Department Medical Academy in Warsaw in 1990-2006]. Otolaryngol Pol; 2008;62(4):395-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The parotid gland's tumours in material of Otolaryngology Department Medical Academy in Warsaw in 1990-2006].
  • INTRODUCTION: The purpose of this work was the desire for handing over authors' experience in diagnostic and operative procedures in the case of the parotid gland's tumours, presenting gathered material, ways of removing tumours and curing results.
  • MATERIAL AND METHODS: The study is the analysis of 317 patients; 180 (58%) women and 131 (42%) men with parotid gland tumours in patients treated in ENT Department between X. 1989 - XII. 2006.
  • The results of histological diagnosis were presented.
  • The frequency of incidence of benign tumours was 81%.
  • Malignant tumours constituted 19% of all parotid gland tumours.
  • (1) There were 81% cases of benign neoplasm and 19% malignant neoplasm in presented material. (2) The result of parotid gland treatment depends on tumor's histopathology, the period of disease, the size of tumour, its expansion into the neighbourhood, infiltrating of the facial nerve and metastases into the lymph nodes. (3) Radical resection of tumour and metastases, reconstructing the continuity of tissues and maintaining the quality of patients life, should be the principle of surgical treatment.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenocarcinoma / surgery. Parotid Neoplasms / epidemiology. Parotid Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Follow-Up Studies. Humans. Incidence. Male. Middle Aged. Neoplasm Staging. Poland / epidemiology. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 18837210.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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16. Houweling AC, Philippens ME, Dijkema T, Roesink JM, Terhaard CH, Schilstra C, Ten Haken RK, Eisbruch A, Raaijmakers CP: A comparison of dose-response models for the parotid gland in a large group of head-and-neck cancer patients. Int J Radiat Oncol Biol Phys; 2010 Mar 15;76(4):1259-65
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  • [Title] A comparison of dose-response models for the parotid gland in a large group of head-and-neck cancer patients.
  • PURPOSE: The dose-response relationship of the parotid gland has been described most frequently using the Lyman-Kutcher-Burman model.
  • We evaluated in a large group of patients the value of six NTCP models that describe the parotid gland dose response 1 year after radiotherapy.
  • METHODS AND MATERIALS: A total of 347 patients with head-and-neck tumors were included in this prospective parotid gland dose-response study.
  • Dose-volume histograms for the parotid glands were derived from three-dimensional dose calculations using computed tomography scans.
  • CONCLUSIONS: The mean dose model was preferred for describing the dose-response relationship of the parotid gland.
  • [MeSH-major] Head and Neck Neoplasms / radiotherapy. Models, Statistical. Parotid Gland / radiation effects. Radiation Injuries / complications. Saliva / secretion

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20005639.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA59827
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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17. Herce-López J, Salazar-Fernández CI, Mayorga-Jiménez F, Gallana-Alvarez S, Pérez-Sánchez JM: Synchronous unilateral parotid neoplasms. A case report. Med Oral Patol Oral Cir Bucal; 2009 Feb;14(2):E90-2
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  • [Title] Synchronous unilateral parotid neoplasms. A case report.
  • The parotid gland is the most usual location of benign neoplasms affecting major salivary glands and quite often the recurrence of these tumours is noticed, specially in the case of pleomorphic adenoma.
  • The occurrence of multiple tumours in the parotid glands is rare and the majority of these are multifocal Warthin's tumors (papillary cystadenoma lymphomatosum).
  • The simultaneous development of tumours with different histological types is unusual and when it occurs, the most common combination is a pleomorphic adenoma and a Warthin's tumor.
  • There are many articles about Multiple Parotid Tumors (MPT) but only a few of them are focused on unilateral synchronous benings tumors, being pleomorphic adenoma and Warthin's these tumors.
  • The report describes a 55 year old female with a pleomorphic adenoma occurring synchronously with a Warthin's tumor within the superficial lobe of her left parotid gland.
  • [MeSH-major] Adenolymphoma. Adenoma, Pleomorphic. Neoplasms, Multiple Primary. Parotid Neoplasms

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  • (PMID = 19179956.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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18. Zhao Y, Zhang W, Zhao J, Li Z, He S: [Reconstruction of soft tissue defects in oral and maxillofacial regions after tumors surgery using cervical pedicle tissue flaps]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2005 Oct;19(10):780-3
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  • Primary sites of the lesions were the tongue (59 cases), buccal mucosa (55 cases), lower gingiva (26 cases), floor of the mouth (25 cases), parotid gland (4 cases) and oropharynx (3 cases).

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  • (PMID = 16274122.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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19. Guevara N, Lassalle S, Castillo L, Butori C, Santini J: [Angiomyolipoma of the parotid gland]. Ann Otolaryngol Chir Cervicofac; 2008 Apr;125(2):90-3
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  • [Title] [Angiomyolipoma of the parotid gland].
  • [Transliterated title] Angiomyolipome de la glande parotide.
  • INTRODUCTION: Angiomyolipoma is a rare benign mesenchymal tumor.
  • MATERIAL AND METHODS: We report a case of angiomyolipoma located in the parotid gland.
  • RESULTS: A 43-year-old man consulted for treatment with a slow-growing nodule located in his right parotid gland.
  • Partial parotidectomy was performed and the tumor showed the characteristic appearance of angiomyolipoma, with an admixture of fat smooth cells and tortuous thick-walled blood vessels.
  • CONCLUSION: This article discusses the presentation and management associated with this exceptional tumor.
  • [MeSH-major] Angiomyolipoma / diagnosis. Parotid Neoplasms / diagnosis

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  • (PMID = 18280455.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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20. Fischer T, Paschen CF, Slowinski T, Alkhameri A, Berl JC, Klingebiel R, Thomas A: Differentiation of parotid gland tumors with contrast-enhanced ultrasound. Rofo; 2010 Feb;182(2):155-62
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  • [Title] Differentiation of parotid gland tumors with contrast-enhanced ultrasound.
  • PURPOSE: Pilot study to evaluate a new ultrasound (US) technique for differentiating parotid cystadenolymphoma (CL) from pleomorphic adenoma (PA).
  • MATERIALS AND METHODS: 27 patients presenting with a palpable lesion of the parotid gland were examined by B-mode US.
  • The contrast medium inflow curves from the tumor and parotid parenchyma were compared by using AUC analysis and compared with histology.
  • AUC analysis for the tumor area demonstrated a significant difference between the PA group (30.3 +/- 24.3 dB/area) and the CL group (77.4 +/- 45.6 dB/area, p < 0.05).
  • [MeSH-major] Adenolymphoma / ultrasonography. Adenoma, Pleomorphic / ultrasonography. Image Enhancement. Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Parotid Neoplasms / ultrasonography. Ultrasonography, Doppler
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Contrast Media / administration & dosage. Contrast Media / pharmacokinetics. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Staging. Parotid Gland / pathology. Parotid Gland / surgery. Parotid Gland / ultrasonography. Phospholipids / pharmacokinetics. Prospective Studies. Sensitivity and Specificity. Sulfur Hexafluoride / pharmacokinetics

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  • (PMID = 19862655.001).
  • [ISSN] 1438-9010
  • [Journal-full-title] RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
  • [ISO-abbreviation] Rofo
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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21. Malikov S, Thomassin JM, Magnan PE, Keshelava G, Bartoli M, Branchereau A: Open surgical reconstruction of the internal carotid artery aneurysm at the base of the skull. J Vasc Surg; 2010 Feb;51(2):323-9
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  • Principal elements of the technique were: partial resection of the parotid gland without rerouting of the facial nerve; luxation of mandibula; drilling of the bone.

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  • [Copyright] Copyright 2010 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20141956.001).
  • [ISSN] 1097-6809
  • [Journal-full-title] Journal of vascular surgery
  • [ISO-abbreviation] J. Vasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Mohammed F, Asaria J, Payne RJ, Freeman JL: Retrospective review of 242 consecutive patients treated surgically for parotid gland tumours. J Otolaryngol Head Neck Surg; 2008 Jun;37(3):340-6
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  • [Title] Retrospective review of 242 consecutive patients treated surgically for parotid gland tumours.
  • OBJECTIVE: To compare the trends and specific outcomes of patients treated surgically for parotid neoplasms between 1994 and 2005 with those of patients who were treated between 1985 and 1993 at Mount Sinai Hospital in Toronto and to identify preoperative indicators of malignancy.
  • Of these patients, 183 (75.6%) had benign neoplasms, 51 (21.1%) had malignant neoplasms, and 8 (3.3%) had inflammatory or lymphatic lesions.
  • [MeSH-major] Parotid Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Diagnosis, Differential. Facial Pain / diagnosis. Facial Pain / epidemiology. Facial Pain / etiology. Female. Humans. Male. Middle Aged. Morbidity / trends. Neoplasm Staging. Ontario / epidemiology. Prognosis. Retrospective Studies. Risk Factors. Survival Rate / trends. Young Adult

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  • (PMID = 19128637.001).
  • [ISSN] 1916-0216
  • [Journal-full-title] Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
  • [ISO-abbreviation] J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Canada
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23. Leibowitz JM, Montone KT, Basu D: Warthin tumor presenting as a fungal abscess in an immunocompetent host: case report and review of the literature. Head Neck; 2010 Jan;32(1):133-6
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  • [Title] Warthin tumor presenting as a fungal abscess in an immunocompetent host: case report and review of the literature.
  • BACKGROUND: Fungal abscesses of the parotid gland are rare, and cases arising within parotid neoplasms have not been described previously.
  • METHODS AND RESULTS: A 59-year-old man experienced multiple recurrences of a parotid fungal abscess requiring repeated drainage procedures.
  • Definitive excision ultimately demonstrated Candida glabrata infecting a Warthin tumor.
  • CONCLUSIONS: This case is the first report of a parotid neoplasm presenting as a fungal abscess.
  • It contributes to the scant literature on fungal abscesses of the parotid, which previously has only been described in debilitated hosts and without an associated neoplasm.
  • Warthin tumor may be an occult etiology for a parotid fungal abscess, and definitive diagnosis and therapy may require parotidectomy.
  • [MeSH-major] Abscess / surgery. Adenolymphoma / surgery. Candida glabrata. Candidiasis / surgery. Immunocompetence. Parotid Neoplasms / surgery

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  • (PMID = 19340859.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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24. Ploquin N, Kay I, Rangel-Baltazar A, Lau H, Dunscombe P: A comparison of techniques for simulating set-up error and uncertainty in head and neck IMRT. Med Phys; 2006 Sep;33(9):3213-9
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  • Discrepancies of up to 20% in the equivalent uniform dose (EUD) between direct simulation and simple convolution were estimated for the relatively superficial parotid gland at a systematic set-up error of 6 mm standard deviation and a random uncertainty of 2 mm standard deviation.

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  • (PMID = 17022214.001).
  • [ISSN] 0094-2405
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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25. Takayama O, Yokoyama J, Ito S: Therapeutic experience of recurrent myoepithelial carcinoma by superselective intra-arterial chemotherapy infused high-dose CDDP. Auris Nasus Larynx; 2006 Jun;33(2):235-8
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  • Myoepithelial carcinoma is one of several new entities added to the updated classification of salivary gland tumors by the WHO in 1991.
  • This tumor most frequently occurs in parotid gland.
  • This is the first report presenting the tumor in floor of the mouth.
  • We confirmed tumor free in FDG-PET in 2 months after the treatment.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma / pathology. Carcinoma / therapy. Mouth Floor / pathology. Myoepithelioma / pathology. Myoepithelioma / therapy. Salivary Gland Neoplasms / pathology. Salivary Gland Neoplasms / therapy

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  • (PMID = 16446069.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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26. Ethunandan M, Vura G, Umar T, Anand R, Pratt CA, Macpherson DW, Wilson AW: Lipomatous lesions of the parotid gland. J Oral Maxillofac Surg; 2006 Nov;64(11):1583-6
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  • [Title] Lipomatous lesions of the parotid gland.
  • PURPOSE: Lipomatous lesions of the parotid gland are rare and seldom considered in the initial diagnosis of a parotid mass.
  • We report our experience in the management of patients with lipomatous lesions affecting the parotid gland.
  • PATIENTS AND METHODS: Retrospective analysis of all parotidectomies performed for neoplastic lesions in the maxillofacial unit between 1975 and 2003 and patients with lipomatous lesions involving the parotid gland were identified; 638 parotidectomies were performed in this period on 629 patients in which 660 neoplasms were identified.
  • RESULTS: Lipomatous lesions accounted for only 1.3% of parotid tumors and occurred more frequently in males, at a ratio of 3 to 1.
  • Computed tomography scan was the most frequent imaging modality undertaken, and in 3 patients a diagnosis of a lipoma was made preoperatively.
  • CONCLUSION: Lipomatous lesions accounted for only 1.3% of all parotid tumors.
  • There were no specific distinguishing clinical features in our patients, and an accurate preoperative diagnosis was made in 3 patients based on imaging investigations.
  • [MeSH-major] Lipoma / surgery. Parotid Gland / surgery. Parotid Neoplasms / surgery

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  • (PMID = 17052582.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Teymoortash A, Schrader C, Shimoda H, Kato S, Werner JA: Evidence of lymphangiogenesis in Warthin's tumor of the parotid gland. Oral Oncol; 2007 Jul;43(6):614-8
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  • [Title] Evidence of lymphangiogenesis in Warthin's tumor of the parotid gland.
  • The details of the pathogenesis of cystadenolymphoma (Warthin's tumor) of the parotid gland are still unclear.
  • Neovascularization is considered to be a pivotal factor for solid tumor progression and biological behavior of the tumor.
  • Using double-labeling immunohistochemistry for LYVE-1 and CD34 (specific markers for lymphatic and vascular endothelial cells, respectively) this study analyzes lymphatic vessel density (LVD) and blood vessel density (BVD) in 10 Warthin's tumors and 10 pleomorphic adenomas of the parotid gland as well as in 5 normal parotid glands and 5 normal parotid lymph nodes.
  • There was no significant difference in the intratumoral LVD and BVD among pleomorphic adenoma and normal parotid gland tissue.
  • In contrast, the intratumoral LVD and BVD were significantly higher in Warthin's tumor than pleomorphic adenoma, normal parotid gland and parotid lymph node (P<0.0001 versus P<0.004).
  • The increase in lymphatic vessels in Warthin's tumor suggests that epithelial tumor cells might promote lymphangiogenesis in this kind of lesions.
  • [MeSH-major] Adenolymphoma / pathology. Lymphangiogenesis. Parotid Neoplasms / pathology

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  • (PMID = 16996778.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / LYVE1 protein, human; 0 / Vesicular Transport Proteins
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28. Li H, Wu GH, Chen FJ, Zhang Q, Wei MW, Chen WK: [Pathological character and treatment of epithelial-myoepithelial carcinoma of salivary gland]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2006 Apr;41(4):281-3
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  • [Title] [Pathological character and treatment of epithelial-myoepithelial carcinoma of salivary gland].
  • METHODS: Retrospectively reviewed 14 cases' pathological and clinical materials of epithelial-myoepithelial carcinoma of salivary gland.
  • Eight cases origine from parotid gland, 2 cases from hard palate, 3 cases from submandibular gland and 1 case from nasal cavity.
  • RESULTS: Tumor arisen mostly from parotid gland and neck lymph node metastasis rate was 14.28% (2/14).
  • [MeSH-major] Carcinoma / pathology. Myoepithelioma / pathology. Salivary Gland Neoplasms / pathology


29. Newton JR, O'Donnell M, Samuel PR: A case of renal cell carcinoma metastasizing to the parotid gland. Otolaryngol Head Neck Surg; 2007 Apr;136(4 Suppl):S65-7
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  • [Title] A case of renal cell carcinoma metastasizing to the parotid gland.
  • [MeSH-major] Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Parotid Neoplasms / secondary

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  • (PMID = 17398347.001).
  • [ISSN] 1097-6817
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Hadi U, Rameh C: Intraglandular toxoplasmosis of the parotid gland pre- or postoperative diagnosis? Am J Otolaryngol; 2007 May-Jun;28(3):201-4
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  • [Title] Intraglandular toxoplasmosis of the parotid gland pre- or postoperative diagnosis?
  • In this article, we present 2 cases of intraglandular parotid toxoplasmosis, one diagnosed postoperatively and the other preoperatively.
  • We also review the relevant literature concerning Toxoplasma infection of the parotid gland.
  • [MeSH-major] Parotid Diseases / parasitology. Toxoplasmosis / diagnosis

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  • (PMID = 17499141.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Protozoan; 0 / Coccidiostats; 0 / Immunoglobulin G; 0 / Immunoglobulin M; 8025-81-8 / Spiramycin
  • [Number-of-references] 13
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31. Ashraf A, Shaikh AS, Kamal F, Sarfraz R, Bukhari MH: Diagnostic reliability of FNAC for salivary gland swellings: a comparative study. Diagn Cytopathol; 2010 Jul;38(7):499-504
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  • [Title] Diagnostic reliability of FNAC for salivary gland swellings: a comparative study.
  • A prospective study was conducted to see the sensitivity, specificity, and accuracy of fine needle aspiration cytology (FNAC) for 100 salivary gland swellings in comparison with biopsy.
  • Parotid gland was involved in 68%, submandibular gland in 30%, and minor salivary glands in 2% patients.
  • Sublingual gland was not involved in any of our subjects.
  • Among neoplastic lesions, biopsy revealed 68 cases of benign neoplasia and 18 cases of malignant neoplasia.
  • Non-neoplastic lesions did not show any difference in diagnosis by both techniques.
  • FNAC misdiagnosed four malignant and one benign lesion.
  • Sensitivity, specificity, positive predictive value, and negative predictive value of FNAC for benign neoplastic lesions were 98.52, 87.05, 94.36, and 96.55%, respectively, whereas for malignant neoplastic lesions they were 77.77, 98.78, 93.33, and 95.29%, respectively.
  • In conclusion, FNAC is found to be a highly sensitive and specific technique for diagnosis of most of salivary gland swellings, except for malignant neoplastic lesions where its sensitivity is intermediate.
  • We strongly recommend that FNAC should be adopted as an initial investigation for all salivary gland swellings.
  • [MeSH-major] Salivary Gland Diseases / diagnosis. Salivary Gland Diseases / pathology. Salivary Glands / pathology
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Biopsy, Fine-Needle. Child. Female. Humans. Male. Middle Aged. Reproducibility of Results. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / pathology. Young Adult

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19950398.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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32. Wiggenraad R, Mast M, van Santvoort J, Hoogendoorn M, Struikmans H: ConPas: a 3-D conformal parotid gland-sparing irradiation technique for bilateral neck treatment as an alternative to IMRT. Strahlenther Onkol; 2005 Oct;181(10):673-82
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  • [Title] ConPas: a 3-D conformal parotid gland-sparing irradiation technique for bilateral neck treatment as an alternative to IMRT.
  • BACKGROUND AND PURPOSE: Intensity-modulated radiotherapy (IMRT) is used in most reported techniques for bilateral neck irradiation that aim at parotid gland sparing.
  • A relatively simple conformal parotid-sparing technique (ConPas) was developed that uses no beam-intensity modulation.
  • The purpose of this paper is to demonstrate, in patients with larynx or hypopharynx carcinoma, that ConPas enables adequate coverage of the primary tumor and the bilateral neck nodes, while keeping the mean parotid dose (MPD) < 26 Gy.
  • A dose of 46 Gy was prescribed to the primary tumor and the bilateral neck nodes, planned either with the conventional technique or ConPas, followed by a boost up to 70 Gy with a simple two-field technique.
  • The target coverage of both techniques was compared using the V(95), the percentage of the planning target volume (PTV) of the primary tumor and nodal regions receiving at least 95% of the prescribed elective dose.
  • The MPDs and the normal-tissue complication probabilities (NTCPs) of the parotid glands were compared using either technique including the boost up to 70 Gy.
  • RESULTS: The mean V(95) was 85.2% and 91.2% (p = 0.08), the mean MPD 38.7 Gy and 25.4 Gy (p < 0.001), and the mean NTCP for the parotid glands 0.87 and 0.22 (p < 0.001) for the conventional technique and ConPas, respectively.
  • CONCLUSION: ConPas enables adequate target coverage and clinically relevant parotid sparing in bilateral neck irradiation without beam-intensity modulation.
  • [MeSH-major] Hypopharyngeal Neoplasms / radiotherapy. Laryngeal Neoplasms / radiotherapy. Parotid Gland / radiation effects. Radiotherapy Dosage. Radiotherapy, Computer-Assisted / methods. Radiotherapy, Conformal / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Humans. Image Processing, Computer-Assisted. Neoplasm Staging

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  • (PMID = 16220407.001).
  • [ISSN] 0179-7158
  • [Journal-full-title] Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
  • [ISO-abbreviation] Strahlenther Onkol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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33. Strege RJ, Kovács G, Maune S, Holland D, Niehoff P, Eichmann T, Mehdorn HM: Feasibility of combined operation and perioperative intensity-modulated brachytherapy of advanced/recurrent malignancies involving the skull base. Strahlenther Onkol; 2005 Feb;181(2):97-107
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  • PATIENTS AND METHODS: This series consisted of 18 consecutive cases: ten patients with paranasal sinus carcinomas, five with sarcomas, two with primitive neuroectodermal tumors (PNETs), and one with parotid gland carcinoma.
  • After, in most cases, subtotal surgical resection (R1-R2: carried out so that the patients' senses of sight were preserved), two to twelve (mean five) afterloading plastic tubes were placed into the tumor bed.
  • Median survival times were 33 months after diagnosis and 16 months after combined operation and IMBT.
  • CONCLUSION: Perioperative fractionated IMBT after extensive but vision-preserving tumor resection seems to be a safe and well-tolerated treatment of advanced/recurrent malignancies involving the skull base.
  • [MeSH-major] Algorithms. Brachytherapy / methods. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Radiotherapy Planning, Computer-Assisted / methods. Radiotherapy, Adjuvant / methods. Skull Neoplasms / radiotherapy. Skull Neoplasms / surgery

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  • (PMID = 15702298.001).
  • [ISSN] 0179-7158
  • [Journal-full-title] Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
  • [ISO-abbreviation] Strahlenther Onkol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
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34. Vyrupaev SV: [Treatment of giant tumors of the parotid gland]. Vopr Onkol; 2005;51(1):128-30
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  • [Title] [Treatment of giant tumors of the parotid gland].
  • Since large (<<giant>>) benign mixed tumors of the parotid gland are rare, there is insufficient evidence on the modalities of the facial nerve management.
  • Tumors were located externally of the gland (5), parapharyngeally (2), or both (1).
  • The regularities between the facial nerve location and site of tumor were investigated, and it is suggested that, in difficult cases, search should start from the temporal area since it offers most access.
  • When tumor of parapharyngeal localization is excised, it is desirable to perform double osteotomy in the mental part of the mandible as well as at the point of entry of the lower of the alveolar nerve, to avoid the latter's being traumatized.
  • [MeSH-major] Parotid Gland / pathology. Salivary Gland Neoplasms / surgery

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  • (PMID = 15909823.001).
  • [ISSN] 0507-3758
  • [Journal-full-title] Voprosy onkologii
  • [ISO-abbreviation] Vopr Onkol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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35. Fierek O, Laskawi R, Kunze E: [Solitary intraparotid neurofibroma of the facial nerve. Symptomatology, biology and management]. HNO; 2006 Oct;54(10):772-7
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  • Neurogenic neoplasms of the parotid gland are extremely uncommon.
  • We present the case of a solitary intraparotid neurofibroma of the N. facialis occurring in a 55-year-old female who noted a painless left-side enlargement in the region of the parotid gland over a period of 2 years.
  • Magnetic resonance imaging revealed a well-demarcated round mass within the left parotid.
  • At surgery, a tumor was found involving the main trunk of the facial nerve, histopathologically representing a neurofibroma.
  • Since solitary intraparotid neurofibromas are characterized by a very slow growth lacking the propensity for malignant transformation, the tumor was left to preserve facial nerve function.
  • Conservative treatment based on facial nerve preservation and leaving the tumor in situ is recommended, rather than radical tumor removal with resection of the segment of the N. facialis involved.
  • [MeSH-major] Cranial Nerve Neoplasms / diagnosis. Facial Nerve Diseases / diagnosis. Neurofibroma / diagnosis. Parotid Gland / innervation
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biopsy. Cell Division / physiology. Facial Nerve / pathology. Facial Nerve / surgery. Female. Humans. Ki-67 Antigen / analysis. Magnetic Resonance Imaging. Middle Aged. Prognosis

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  • [ISSN] 0017-6192
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
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36. Chhabra N, Chhabra S, Kapila SA: Use of hypertonic saline in the management of parotid fistulae and sialocele: a report of 2 cases. J Maxillofac Oral Surg; 2009 Mar;8(1):64-7
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  • [Title] Use of hypertonic saline in the management of parotid fistulae and sialocele: a report of 2 cases.
  • Parotid fistula is a well known complication of parotidectomy or penetrating injury of the parotid gland.
  • In cases of external fistulae, the principles of management aim at the return of normal parotid function in both acute and chronic parotid injury, but sometimes the alternative is to depress parotid secretions to allow natural healing process to seal the injury.The paper highlights the indications, techniques, advantages and disadvantages of using osmotic sclerosant for the management of parotid fistulae.
  • We used warm hypertonic saline injections within the glandular substance to cause rapid fibrosis of the gland in 2 patients of chronic parotid fistulae.This technique is a simple and effective method of dealing with salivary leak.

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  • (PMID = 23139474.001).
  • [ISSN] 0972-8279
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3454011
  • [Keywords] NOTNLM ; Hypertonic saline / Osmotic sclerosants / Salivary fistula / Sialocele
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37. Ward BK, Seethala RR, Barnes EL, Lai SY: Basal cell adenocarcinoma of a hard palate minor salivary gland: case report and review of the literature. Head Neck Oncol; 2009 Dec 23;1:41
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  • [Title] Basal cell adenocarcinoma of a hard palate minor salivary gland: case report and review of the literature.
  • OBJECTIVE: Basal cell adenocarcinoma of a minor salivary gland is extremely rare.
  • The goal of this report is to increase awareness of this rare disease and to review and discuss the differential diagnosis and important considerations in treatment.
  • METHODS: Case report of a basal cell adenocarcinoma of a hard palate minor salivary gland and review of the literature of basal cell adenocarcinoma.
  • RESULTS: Basal cell adenocarcinomas are slow-growing tumours that most commonly involve the parotid gland and very rarely involve minor salivary glands.
  • Histological diagnosis is important to distinguish this tumour from adenoid cystic carcinoma given the significant difference in disease prognosis.
  • CONCLUSIONS: Diagnosis of these tumours must be made histologically.

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  • (PMID = 20030819.001).
  • [ISSN] 1758-3284
  • [Journal-full-title] Head & neck oncology
  • [ISO-abbreviation] Head Neck Oncol
  • [Language] ENG
  • [Grant] United States / NIDCR NIH HHS / DE / K08 DE018061
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2806868
  • [General-notes] NLM/ Original DateCompleted: 20100629
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38. Bozkaya S, Uğar D, Karaca I, Ceylan A, Uslu S, Bariş E, Tokman B: The treatment of lymphangioma in the buccal mucosa by radiofrequency ablation: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Nov;102(5):e28-31
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  • Lymphangioma is a benign, hamartomatous tumor of the lymphatic system.
  • It is usually found in the head and neck region and is widely regarded as a developmental lesion rather than a true neoplasia.
  • In the head and neck area, the most common location is the submandibular region, followed by the parotid gland.

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  • (PMID = 17052620.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Kilic C, Kirici Y, Kocaoglu M: Double facial nerve trunk emerged from the stylomastoid foramen and petrotympanic fissure: a case report. J Korean Med Sci; 2010 Aug;25(8):1228-30
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  • The facial nerve trunk can be damaged during surgical procedures of the parotid gland tumours and submandibular region.
  • [MeSH-minor] Aged. Cadaver. Humans. Magnetic Resonance Imaging. Male. Parotid Gland / innervation

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  • (PMID = 20676338.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2908796
  • [Keywords] NOTNLM ; Facial Nerve Trunk / Variation
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40. Palmieri A, Carinci F, Martinelli M, Spinelli G, Lo Muzio L, Rubini C, Scapoli L: Absence of Simian virus 40, BK, and JC polyomavirus DNA in squamous cell carcinoma limited to the oral cavity. Head Neck; 2010 Mar;32(3):375-80
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  • The Simian virus 40 (SV40), which is a polyomavirus known for its oncogenic potential, was found as a contaminant of oral vaccines and has been related to human pleomorphic adenoma in the parotid gland.


41. Van Sickels JE: Management of parotid gland and duct injuries. Oral Maxillofac Surg Clin North Am; 2009 May;21(2):243-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of parotid gland and duct injuries.
  • Surgical repair of injuries to the parotid gland and its duct have been described in the literature for more than 100 years.
  • [MeSH-major] Parotid Gland / injuries. Salivary Ducts / injuries

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  • (PMID = 19348990.001).
  • [ISSN] 1558-1365
  • [Journal-full-title] Oral and maxillofacial surgery clinics of North America
  • [ISO-abbreviation] Oral Maxillofac Surg Clin North Am
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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42. Iwai H, Yamashita T: [Surgical procedure for Warthin's tumor in the parotid gland]. Nihon Jibiinkoka Gakkai Kaiho; 2005 Jun;108(6):679-83
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  • [Title] [Surgical procedure for Warthin's tumor in the parotid gland].
  • Warthin's tumor is benign and exclusively involves the parotid gland but may, however, often show multifocal and/or bilateral growth.
  • The aim of this study was to evaluate the surgical procedure for removal of this tumor.
  • Sixty patients with Warthin's tumor in the parotid gland who presented at the Kansai Medical University Hospital from 1990 to 1999 were the subjects of the present study.
  • Tumors in the superficial lobe were resected with partial parotidectomy, and an enucleative procedure was also performed at the bottom of the tumor where the tumor capsule directly touched the facial nerve.
  • Therefore, we recommend that enucleation is a useful choice as a surgical procedure for the removal of Warthin's tumor after accurate detection of the tumors using MRI.
  • These findings indicate that more careful consideration for preservation of the facial nerve should be given in such cases and that simultaneous surgery for such tumors in the bilateral parotid glands should be avoided to prevent bilateral facial nerve palsy.
  • [MeSH-major] Adenolymphoma / surgery. Otorhinolaryngologic Surgical Procedures / methods. Parotid Neoplasms / surgery

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  • (PMID = 16001725.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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43. Erdogan F, Altas S, Altas E, Yoruk O, Ozmen SA: A rare location of Castleman's disease: parotid region. N Z Med J; 2008 Jul 25;121(1278):86-90
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  • [Title] A rare location of Castleman's disease: parotid region.
  • Castleman's disease in the parotid gland region is very rare.
  • A 15-year-old female with Castleman's disease in the parotid region is herein reported.
  • [MeSH-major] Giant Lymph Node Hyperplasia / pathology. Giant Lymph Node Hyperplasia / surgery. Parotid Diseases / pathology. Parotid Diseases / surgery

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  • (PMID = 18670479.001).
  • [ISSN] 1175-8716
  • [Journal-full-title] The New Zealand medical journal
  • [ISO-abbreviation] N. Z. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] New Zealand
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44. Yu KJ, Lee HE, Ho HC, Lee JC, Chang JW, Hong HS, Yang CH: Carcinoma erysipelatoides from squamous cell carcinoma of unknown origin. Int J Clin Pract; 2005 Sep;59(9):1104-6
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  • The characteristic histopathological finding is metastatic tumour cells inside the dermal lymphatic ducts.
  • It is frequently observed in patients with breast carcinoma as well as adenocarcinoma of pancreas, rectum, lung, ovary and parotid gland.

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  • (PMID = 16115190.001).
  • [ISSN] 1368-5031
  • [Journal-full-title] International journal of clinical practice
  • [ISO-abbreviation] Int. J. Clin. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 13
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45. David O, Blaney S, Hearp M: Parotid gland fine-needle aspiration cytology: an approach to differential diagnosis. Diagn Cytopathol; 2007 Jan;35(1):47-56
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  • [Title] Parotid gland fine-needle aspiration cytology: an approach to differential diagnosis.
  • Parotid glands can undergo a wide range of pathologic changes that may be difficult to characterize by clinical features alone.
  • No single diagnostic modality is currently accepted unequivocally as the definitive approach to parotid gland enlargement or tumors.
  • (1) to define the clinical role of parotid FNA, such that pathologists performing and/or interpreting such specimens have a clearer understanding of the expectations of our surgical colleagues;.
  • (2) to clearly describe a protocol for the performance of parotid FNA biopsy, including a discussion of complications and pitfalls; and (3) to present the cytologic differential diagnoses of diverse clinicopathologic parotid gland processes that may present as generalized enlargement, cystic lesions, or discrete masses.
  • [MeSH-major] Biopsy, Fine-Needle. Parotid Diseases / pathology. Parotid Gland / pathology
  • [MeSH-minor] Clinical Protocols. Diagnosis, Differential. Humans. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 17173301.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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46. Anand AK, Jain J, Negi PS, Chaudhoory AR, Sinha SN, Choudhury PS, Kumar R, Munjal RK: Can dose reduction to one parotid gland prevent xerostomia?--A feasibility study for locally advanced head and neck cancer patients treated with intensity-modulated radiotherapy. Clin Oncol (R Coll Radiol); 2006 Aug;18(6):497-504
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  • [Title] Can dose reduction to one parotid gland prevent xerostomia?--A feasibility study for locally advanced head and neck cancer patients treated with intensity-modulated radiotherapy.
  • In this study, parotid function was assessed in patients with locally advanced head and neck cancers undergoing intensity-modulated radiotherapy (IMRT) with or without chemotherapy.
  • Parotid function was assessed with the help of a questionnaire and parotid scintigraphy, especially with regards to unilateral sparing of the parotid gland.
  • RESULTS: Subjective toxicity to the parotid glands was assessed with the help of a questionnaire at 0, 3 and 6 months and objective toxicity was assessed with parotid scintigraphy at 0 and 3 months.
  • The mean dose to the ipsilateral parotid gland ranged from 19.5 to 52.8 Gy (mean 33.14 Gy) and the mean dose to the contralateral gland was 11.1-46.6 Gy (mean 26.85 Gy).
  • At a median follow-up of 13 months, 9/19 patients had no symptoms of dryness of the mouth (grade I), 8/19 had mild dryness of the mouth (grade II) and only 2/19 had grade III xerostomia, although the parotid gland could only be spared on one side in most of the patients.
  • CONCLUSIONS: Minimising the radiation dose to one of the parotid glands with the help of IMRT in patients with advanced head and neck cancers can prevent xerostomia in most patients and parotid scintigraphy is a useful method of documenting xerostomia.
  • [MeSH-major] Head and Neck Neoplasms / radiotherapy. Parotid Gland / radiation effects. Radiotherapy, Intensity-Modulated / adverse effects. Xerostomia / prevention & control
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Disease Progression. Dose-Response Relationship, Radiation. Feasibility Studies. Follow-Up Studies. Humans. Magnetic Resonance Imaging / methods. Neoplasm Recurrence, Local. Neoplasm Staging. Radionuclide Imaging. Radiotherapy Dosage. Sensitivity and Specificity. Surveys and Questionnaires. Tomography, X-Ray Computed / methods. Treatment Outcome

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  • (PMID = 16909975.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] England
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47. Fodor D, Pop S, Maniu A, Cosgaria M: Gray scale and Doppler ultrasonography of the benign tumors of parotid gland (pleomorphic adenoma and Warthin's tumor). Pictorial essay. Med Ultrason; 2010 Sep;12(3):238-44
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  • [Title] Gray scale and Doppler ultrasonography of the benign tumors of parotid gland (pleomorphic adenoma and Warthin's tumor). Pictorial essay.
  • The purpose of this pictorial essay is to illustrate the ultrasonographic aspects of the most common benign tumors of the parotid gland: pleomorphic adenoma and Warthin's tumor.
  • [MeSH-major] Adenolymphoma / ultrasonography. Adenoma, Pleomorphic / ultrasonography. Parotid Neoplasms / ultrasonography. Ultrasonography, Doppler

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  • (PMID = 21203603.001).
  • [ISSN] 1844-4172
  • [Journal-full-title] Medical ultrasonography
  • [ISO-abbreviation] Med Ultrason
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Romania
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48. Jen YM, Shih R, Lin YS, Su WF, Ku CH, Chang CS, Shueng PW, Hwang JM, Liu DW, Chao HL, Lin HY, Chang LP, Shum WY, Lin CS: Parotid gland-sparing 3-dimensional conformal radiotherapy results in less severe dry mouth in nasopharyngeal cancer patients: a dosimetric and clinical comparison with conventional radiotherapy. Radiother Oncol; 2005 May;75(2):204-9
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  • [Title] Parotid gland-sparing 3-dimensional conformal radiotherapy results in less severe dry mouth in nasopharyngeal cancer patients: a dosimetric and clinical comparison with conventional radiotherapy.
  • BACKGROUND AND PURPOSE: This study examined the efficacy of parotid gland sparing of three-dimensional conformal radiotherapy (3DCRT) compared with conventional radiotherapy for NPC patients.
  • RESULTS: In the 3DCRT group about 50% of the patients' parotid glands received less than 25 Gy.
  • Although 3DCRT delivered a higher dose to the tumor, it spared the parotid gland significantly better than the conventional treatment.
  • CONCLUSION: Dosimetrically and clinically 3DCRT is better than conventional technique regarding parotid gland protection.
  • [MeSH-major] Nasopharyngeal Neoplasms / radiotherapy. Parotid Gland / radiation effects. Radiation Injuries / prevention & control. Radiotherapy, Conformal / methods. Xerostomia / etiology. Xerostomia / prevention & control

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  • (PMID = 15908027.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
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49. Isolan GR, Rowe R, Al-Mefty O: Microanatomy and surgical approaches to the infratemporal fossa: an anaglyphic three-dimensional stereoscopic printing study. Skull Base; 2007 Sep;17(5):285-302
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  • The maxillary artery is the terminal branch of the external carotid artery that originates at the neck of the mandible and runs into the parotid gland.
  • CONCLUSIONS: The ITF is a complex region on the skull base that is affected by benign and malignant tumors.

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  • (PMID = 18330427.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2095118
  • [Keywords] NOTNLM ; Infratemporal fossa / approaches / mandibular nerve / paraganglioma / surgical anatomy
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50. Tavora F, Rassaei N, Shilo K, Foss RD, Galvin JR, Travis WD, Franks TJ: Occult primary parotid gland acinic cell adenocarcinoma presenting with extensive lung metastasis. Arch Pathol Lab Med; 2007 Jun;131(6):970-3
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  • [Title] Occult primary parotid gland acinic cell adenocarcinoma presenting with extensive lung metastasis.
  • Acinic cell adenocarcinoma is a malignant salivary gland neoplasm with a relatively low rate of lymphangitic spread to regional lymph nodes.
  • We encountered an unusual example of acinic cell adenocarcinoma that initially presented in the lung, whereas the primary parotid carcinoma, despite extensive clinical evaluation, only became apparent 1 year after initial diagnosis.
  • The histologic, immunohistochemical, and ultrastructural features of the tumor in the parotid gland and lung were similar.
  • The tumor displayed an aggressive behavior resulting in death within 2 years of the initial presentation.
  • This presentation is unique, showing that peripheral lung tumors of salivary gland type are likely to be metastatic, and careful clinical evaluation is warranted in establishing their primary site of origin.
  • [MeSH-major] Carcinoma, Acinar Cell / secondary. Lung Neoplasms / secondary. Parotid Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Fatal Outcome. Female. Humans. Palliative Care

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  • (PMID = 17550329.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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51. Rong R, Zhang CY, Wang XY: Normal appearance of large field diffusion weighted imaging on 3.0T MRI. Chin Med Sci J; 2008 Sep;23(3):158-61
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  • METHODS: Twenty healthy volunteers and thirty patients with benign prostate hyperplasia were included in this study.
  • RESULTS: Salivary gland, spleen, kidney, gallbladder, bladder, prostate, seminal vesicle, testis, intervertebral disk, liquid in articular cavity and lymph node showed high signal intensity on large field DWI, while lung, liver and bone showed hypo-signal intensity.
  • The mean ADC values of partial hyperintensity tissue were as followed: parotid gland (1.088 +/- 0.114) x 10(-3) mm2/S, submaxillary gland (1.309 +/- 0.189) x 10(-3) mm2/s, kidney (1.909 +/- 0.143) x 10(-3) mm2/s, seminal vesicle (1.669 +/- 0.168) x 10(-3) mm2/s, testis (1.028 +/- 0.075) x 10(-3) mm2/s, spleen (0.963 +/- 0.108) x 10(-3) mm2/s, bladder (2.898 +/- 0.267) x 10(-3) mm2/s, prostate (1.448 +/- 0.132) x 10(-3) mm2/s, intervertebral disks (1.360 +/- 0.140) x 10(-3) mm2/s.

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  • (PMID = 18853850.001).
  • [ISSN] 1001-9294
  • [Journal-full-title] Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih
  • [ISO-abbreviation] Chin. Med. Sci. J.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] China
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52. Ortholan C, Chamorey E, Benezery K, Thariat J, Dassonville O, Poissonnet G, Bozec A, Follana P, Peyrade F, Sudaka A, Gerard JP, Bensadoun RJ: Modeling of salivary production recovery after radiotherapy using mixed models: determination of optimal dose constraint for IMRT planning and construction of convenient tools to predict salivary function. Int J Radiat Oncol Biol Phys; 2009 Jan 1;73(1):178-86
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  • PURPOSE: The mathematical relationship between the dose to the parotid glands and salivary gland production needs to be elucidated.
  • The data of salivary production, time of follow-up, and dose to parotid gland were modeled using a mixed model.
  • Several models were developed to assess the best-fitting variable for the dose level to the parotid gland.
  • RESULTS: Models developed with the dose to the contralateral parotid fit the data slightly better than those with the dose to both parotids, suggesting that contralateral and ipsilateral parotid glands are not functionally equivalent even with the same dose level to the glands.
  • The best predictive dose-value variable for salivary flow recovery was the volume of the contralateral parotid gland receiving >40 Gy.
  • CONCLUSION: The results of this study show that the recommendation of a dose constraint for intensity-modulated RT planning should be established at the volume of the contralateral parotid gland receiving >40 Gy rather than the mean dose.
  • For complete salivary production recovery after 24 months, the volume of the contralateral parotid gland receiving >40 Gy should be <33%.
  • Our results permitted us to establish two convenient tools to predict the saliva production recovery function according to the dose received by the contralateral parotid gland.
  • [MeSH-major] Algorithms. Nasopharyngeal Neoplasms / radiotherapy. Oropharyngeal Neoplasms / radiotherapy. Radiotherapy Planning, Computer-Assisted / methods. Radiotherapy, Conformal / adverse effects. Salivary Gland Diseases / prevention & control. Salivation / radiation effects

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  • (PMID = 18565687.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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53. Lee TK, Rosen II, Gibbons JP, Fields RS, Hogstrom KR: Helical tomotherapy for parotid gland tumors. Int J Radiat Oncol Biol Phys; 2008 Mar 1;70(3):883-91
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  • [Title] Helical tomotherapy for parotid gland tumors.
  • PURPOSE: To investigate helical tomotherapy (HT) intensity-modulated radiotherapy (IMRT) as a postoperative treatment for parotid gland tumors.
  • Tumor control probabilities were higher for 3 of the 4 patients.
  • Helical tomotherapy is an effective alternative to SMLC IMRT for treatment of parotid tumors.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Parotid Neoplasms / radiotherapy. Radiotherapy, Intensity-Modulated / methods
  • [MeSH-minor] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / radiography. Carcinoma, Adenoid Cystic / radiotherapy. Humans. Radiotherapy Dosage. Radiotherapy Planning, Computer-Assisted / methods. Tomography, Spiral Computed. Tumor Burden

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  • (PMID = 18164857.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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54. Grădinaru I, Ghiciuc CM, Popescu E, Nechifor C, Mândreci I, Nechifor M: Blood plasma and saliva levels of magnesium and other bivalent cations in patients with parotid gland tumors. Magnes Res; 2007 Dec;20(4):254-8
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  • [Title] Blood plasma and saliva levels of magnesium and other bivalent cations in patients with parotid gland tumors.
  • The plasma and saliva cations in parotid malignant tumors of stages II-III were studied in 31 patients before surgical therapy and in 27 control group volunteers.
  • Our results showed that salivary and plasma t-Mg concentrations were significantly higher in patients with parotid malignant tumors in comparison to control group (saliva: 0.25 +/- 0.04 mmol/L versus 0.14 +/- 0.03/L, p < 0.01; plasma: 1.05 +/- 0.06 mmol/L versus 0.86 +/- 0.05 mmol/L, p < 0.05).
  • The t-Ca plasma concentrations were lower for patients with parotid malignant tumors by 20-22% in comparison to the control group (p < 0.05).
  • Plasma and salivary t-Mg/t-Ca molar ratios are respectively 0.38 and 0.12 for control group, and respectively 0.61 and 0.31 for patients with parotid gland tumors.
  • The t-Zn plasma concentration for patients with parotid malignant tumors (0.017 +/- 0.010 mmol/L) was significantly lower (p < 0.05) in comparison to control group (0.024 +/- 0.011 mmol/L).
  • Plasma t-Cu/t-Zn molar ratio is respectively 0.68 for control group and 1.12 for patients with parotid gland tumors.
  • [MeSH-major] Cations, Divalent / analysis. Cations, Divalent / blood. Magnesium / analysis. Magnesium / blood. Parotid Neoplasms / blood. Saliva / chemistry

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  • (PMID = 18271496.001).
  • [ISSN] 0953-1424
  • [Journal-full-title] Magnesium research
  • [ISO-abbreviation] Magnes Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cations, Divalent; 789U1901C5 / Copper; I38ZP9992A / Magnesium; J41CSQ7QDS / Zinc; SY7Q814VUP / Calcium
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55. Alvarez-Buylla Blanco M, Martínez Moran A, Vázquez Barro JC, Vidal JM: [Primary non-Hodgkin lymphoma of the parotid gland: Revision of 8 cases]. Acta Otorrinolaringol Esp; 2010 Sep-Oct;61(5):371-4
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  • [Title] [Primary non-Hodgkin lymphoma of the parotid gland: Revision of 8 cases].
  • [Transliterated title] Linfoma no Hodgkin primario de la glándula parótida: revisión de 8 casos.
  • The manifestation of non-Hodgkin lymphoma as a primary parotid tumour account for 5% of all tumours at this location.
  • We present 8 patients diagnosed and treated for parotid non-Hodgkin lymphoma in our hospital between 1996 and 2003.
  • The immunohistochemical study provided us with the definitive diagnosis.
  • [MeSH-major] Lymphoma, Non-Hodgkin. Parotid Neoplasms

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  • [Copyright] Copyright © 2009 Elsevier España, S.L. All rights reserved.
  • (PMID = 20346432.001).
  • [ISSN] 1988-3013
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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56. Zainal A, Razif MY, Makhashen M, Swaminathan M, Mazita A: Necrobiotic xanthogranuloma of the parotid gland. J Laryngol Otol; 2010 May;124(5):569-71
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  • [Title] Necrobiotic xanthogranuloma of the parotid gland.
  • OBJECTIVES: To highlight the first reported case of necrobiotic xanthogranuloma of the parotid gland.
  • RESULTS: A 48-year-old man presented with a right parotid mass.
  • Fine needle aspiration cytology was suggestive of Warthin's tumour, for which the patient underwent a subtotal parotidectomy.
  • The final histopathological diagnosis was necrobiotic xanthogranuloma.
  • CONCLUSIONS: Necrobiotic xanthogranuloma may clinically mimic commoner tumours such as Warthin's tumour.
  • [MeSH-major] Granuloma / pathology. Parotid Diseases / pathology. Xanthomatosis / pathology

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  • (PMID = 19825226.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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57. Chen AM, Farwell DG, Luu Q, Chen LM, Vijayakumar S, Purdy JA: Misses and near-misses after postoperative radiation therapy for head and neck cancer: Comparison of IMRT and non-IMRT techniques in the CT-simulation era. Head Neck; 2010 Nov;32(11):1452-9
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  • Among the local-regional recurrences in the IMRT group, 9 were in-field recurrences occurring within the physician-designated clinical target volume (CTV), and 4 were marginal recurrences involving the contralateral neck adjacent to the spared parotid gland (3 patients) and the retropharyngeal/retrostyloid lymph node region (1 patient).
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Head and Neck Neoplasms / therapy. Neoplasm Recurrence, Local / pathology. Radiotherapy, Intensity-Modulated

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  • (PMID = 20146333.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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58. Chang KT, Chadha NK, Leung R, Shago M, Phillips MJ, Thorner PS: Lymphadenoma: case report of a rare salivary gland tumor in childhood. Pediatr Dev Pathol; 2010 Jul-Aug;13(4):331-7
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  • [Title] Lymphadenoma: case report of a rare salivary gland tumor in childhood.
  • Lymphadenoma of the salivary gland is a rare benign tumor with only 11 reported cases in the English language literature, most of which have occurred in adults.
  • We report a case of a lymphadenoma occurring in the parotid gland of a 15-year-old girl.
  • The tumor was composed of variably sized cystic cavities within abundant reactive lymphoid tissue.
  • Tumor cells were not cycling as determined by MIB1 immunostaining, and the tumor karyotype was normal.
  • Although this tumor is rarely encountered by pediatric pathologists, awareness of its existence is important to distinguish it from possible malignant mimics, such as lymphoepithelial carcinoma and metastatic mucoepidermoid carcinoma in a lymph node.
  • [MeSH-major] Adenolymphoma / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adolescent. Biomarkers, Tumor / metabolism. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / secondary. Cytoplasmic Structures / ultrastructure. Diagnosis, Differential. Female. Humans. Keratins / metabolism. Lymphocytes / ultrastructure. Plasma Cells / ultrastructure. Proto-Oncogene Proteins c-kit / metabolism. Trans-Activators / metabolism. Transcription Factors. Treatment Outcome. Tumor Suppressor Proteins / metabolism

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  • (PMID = 20021220.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 68238-35-7 / Keratins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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59. Lahoz Zamarro MT, Galve Royo A, Galve Royo F: [Tumoral pathology of salivary glands. Our experience]. Acta Otorrinolaringol Esp; 2009 Mar-Apr;60(2):120-5
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  • [Transliterated title] Afección tumoral de las glándulas salivales. Nuestra experiencia.
  • INTRODUCTION AND OBJECTIVES: We report a descriptive epidemiologic study of 63 patients with major and minor salivary gland tumours diagnosed at our centre over the last ten years.
  • RESULTS: Among the 38 males and 25 females, we found 39 with benign tumours and 24 with malignant tumours.
  • Most of these tumours (42; 67%) arose in the parotid gland, 12 (19%) in the submaxillary gland, 7 (11%) in the palate and 2 (3%) in external auditory canal.
  • The mean age was 54 years for benign tumours and 80 years for malignant ones.
  • The most common benign tumours found were pleomorphic adenomas (67%) whereas epidermoid carcinoma (54%) followed by lymphomas (25%) were the most frequent among malignant tumours.
  • [MeSH-major] Salivary Gland Neoplasms

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  • (PMID = 19401079.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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60. Choi JH, Jo H, Hong JH, Lee SI, Shin DM: Alteration of expression of Ca2+ signaling proteins and adaptation of Ca2+ signaling in SERCA2+/- mouse parotid acini. Yonsei Med J; 2008 Apr 30;49(2):311-21
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  • [Title] Alteration of expression of Ca2+ signaling proteins and adaptation of Ca2+ signaling in SERCA2+/- mouse parotid acini.
  • However, whether the changes in Ca2+ signaling and Ca2+ signaling proteins in parotid acinar cells are affected by a partial loss of SERCA2 are not known.
  • MATERIALS AND METHODS: In SERCA2+/- mouse parotid gland acinar cells, Ca2+ signaling, expression levels of Ca2+ signaling proteins, and amylase secretion were investigated.
  • CONCLUSION: These results suggest that a partial loss of SERCA2 affects the expression and activity of Ca2+ signaling proteins in the parotid gland acini, however, overall Ca2+ signaling is unchanged.
  • [MeSH-major] Calcium Signaling / physiology. Parotid Gland / metabolism. Sarcoplasmic Reticulum Calcium-Transporting ATPases / metabolism

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  • (PMID = 18452270.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Inositol 1,4,5-Trisphosphate Receptors; 8Y164V895Y / Carbachol; EC 3.2.1.- / Amylases; EC 3.6.3.8 / Sarcoplasmic Reticulum Calcium-Transporting ATPases; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC2615323
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61. Lanlua P, Sricharoenvej S, Niyomchan A, Chico DE: Unique cellular structures in the parotid gland of an Old world fruit bat, Pteropus lylei (Lyle's flying fox). Ital J Anat Embryol; 2007 Jul-Sep;112(3):179-90
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  • [Title] Unique cellular structures in the parotid gland of an Old world fruit bat, Pteropus lylei (Lyle's flying fox).
  • The carpophagous diet of P. lylei presents an adaptive challenge for salivary glands to conserve sufficient nutrition for living.
  • Therefore, the parotid glands in both sexes were investigated by using light microscopy and transmission electron microscopy.
  • No structural difference was observed in the parotid glands between sexes.
  • The morphological adaptation of the parotid gland observed in P. lylei enables this species to obtain sufficient nutrients from the preferred consumption of ripe fruit.
  • Structural variations in the parotid gland can indicate not only a correlation to diet and survival but also a close relationship of the Old World fruit bat to other kinds of bats.
  • [MeSH-major] Chiroptera / anatomy & histology. Digestion / physiology. Epithelial Cells / ultrastructure. Food Habits / physiology. Parotid Gland / ultrastructure

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  • (PMID = 18078239.001).
  • [ISSN] 1122-6714
  • [Journal-full-title] Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia
  • [ISO-abbreviation] Ital J Anat Embryol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Dietary Proteins
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62. Abdelkrim SB, Trabelsi A, Hammedi F, Omezzine M, Rammeh S, Abdelkader AB, Sriha B: Primary lymphoepithelial carcinoma of the parotid gland in a North African woman. Rare Tumors; 2009;1(1):e16
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  • [Title] Primary lymphoepithelial carcinoma of the parotid gland in a North African woman.
  • Lymphoepithelial carcinoma of the salivary glands is a rare neoplasm that is characterized by a non-neoplastic lymphocytic infiltration associated with an epithelial proliferation.
  • It involves mainly the parotid gland.
  • Racial and geographical factors contribute to the pathogenesis of this tumor.
  • We report a case of a 70-year old woman from a non-endemic area who presented with several months history of swelling in the parotid region.
  • Magnetic resonance imaging showed a parotid mass suggestive of a pleomorphic adenoma.
  • The diagnosis of lymphoepithelial carcinoma of the parotid gland was performed on the surgical specimen.

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  • (PMID = 21139887.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994432
  • [Keywords] NOTNLM ; lymphoepithelial carcinoma / parotid / pathology.
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63. Colella G, Cannavale R, Vicidomini A, Itro A: Salivary gland biopsy: a comprehensive review of techniques and related complications. Rheumatology (Oxford); 2010 Nov;49(11):2117-21
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  • [Title] Salivary gland biopsy: a comprehensive review of techniques and related complications.
  • OBJECTIVE: This study proposes a revision of the literature on the current techniques employed in salivary gland biopsy.
  • The search terms were: 'biopsy AND parotid AND Sjögren'; 'biopsy AND sublingual salivary gland AND Sjögren'; 'biopsy AND minor salivary gland AND Sjögren'; 'biopsy AND labial salivary gland AND Sjögren' and 'biopsy AND salivary glands AND connective disorders'.
  • RESULTS: No study reporting submandibular salivary gland biopsy was found; 3 studies reported sublingual salivary gland biopsy; 1 study reported palate biopsy; 4 studies reported parotid gland biopsy and 21 studies reported minor salivary gland biopsy.
  • CONCLUSION: Biopsy of salivary glands must be performed as last investigation and only when the other items are not complete enough to satisfy the diagnosis.
  • [MeSH-major] Salivary Gland Diseases / pathology. Salivary Glands / pathology. Sjogren's Syndrome / pathology

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  • (PMID = 20660500.001).
  • [ISSN] 1462-0332
  • [Journal-full-title] Rheumatology (Oxford, England)
  • [ISO-abbreviation] Rheumatology (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
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64. Habermann CR, Gossrau P, Graessner J, Arndt C, Cramer MC, Reitmeier F, Jaehne M, Adam G: Diffusion-weighted echo-planar MRI: a valuable tool for differentiating primary parotid gland tumors? Rofo; 2005 Jul;177(7):940-5
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  • [Title] Diffusion-weighted echo-planar MRI: a valuable tool for differentiating primary parotid gland tumors?
  • PURPOSE: To investigate the feasibility of using diffusion-weighted (DW) echo-planar imaging (EPI) for differentiating primary parotid gland tumors.
  • MATERIAL AND METHODS: Fifty consecutive patients with a suspected primary tumor of the parotid gland were examined with a DW EPI sequence (TR 1,500 msec, TE 77 msec, field of view 250 x 250 mm, pixel size 2.10 x 1.95 mm, section thickness 5 mm).
  • The b factors used were 0, 500, and 1,000 sec/mm (2).
  • Apparent diffusion coefficient (ADC) maps were digitally transferred to MRIcro (Chris Rorden, University of Nottingham, Great Britain) and evaluated with a manually placed irregular region of interest (ROI) containing the entire tumor.
  • Additionally, the contralateral, non affected parotid gland was measured and a circular ROI containing 100 - 200 pixels was placed in the cerebrospinal fluid (CSF) next to the spinal cord in every patient.
  • RESULTS: In 45 patients, a primary neoplasm of the parotid gland could be histologically verified.
  • For the non-affected parotid glands of all 45 evaluated patients, the mean ADC value was 1.14 x 10 ( - 3) mm (2)/sec +/- 0.12 x 10 ( - 3) mm (2)/sec (mean +/- standard deviation).
  • Seven different entities of parotid gland tumors were histologically discriminated.
  • Among all other [corrected] primary malignant parotid gland tumors, no statistically significant ADC values could be observed (p .18 to 1).
  • CONCLUSION: Diffusion-weighted echo-planar MRI seems to be a valuable tool for differentiating benign from malignant primary parotid gland tumors.
  • [MeSH-major] Diffusion Magnetic Resonance Imaging / methods. Echo-Planar Imaging / methods. Image Enhancement / methods. Image Interpretation, Computer-Assisted / methods. Parotid Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Diagnosis, Differential. Feasibility Studies. Female. Humans. Male. Middle Aged. Reproducibility of Results. Sensitivity and Specificity

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  • [ErratumIn] Rofo. 2005 Sep;177(9):1312
  • (PMID = 15973595.001).
  • [ISSN] 1438-9029
  • [Journal-full-title] RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
  • [ISO-abbreviation] Rofo
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
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65. Gordin EA, Daniero JJ, Krein H, Boon MS: Parotid gland trauma. Facial Plast Surg; 2010 Dec;26(6):504-10
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  • [Title] Parotid gland trauma.
  • Parotid trauma can lead to both short and long-term complications such as bleeding, infection, facial nerve injury, sialocele, and salivary fistula, resulting in pain and disfigurement.
  • Facial injuries inferior to a line extended from the tragus to the upper lip should raise concern for parotid injury.
  • [MeSH-major] Facial Injuries / surgery. Parotid Gland / injuries. Postoperative Complications / prevention & control. Reconstructive Surgical Procedures / methods


66. González-García R, Nam-Cha SH, Muñoz-Guerra MF, Gamallo-Amat C: Basal cell adenoma of the parotid gland. Case report and review of the literature. Med Oral Patol Oral Cir Bucal; 2006 Mar;11(2):E206-9
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  • [Title] Basal cell adenoma of the parotid gland. Case report and review of the literature.
  • Its most frequent location is the parotid gland.
  • Due to prognostic implications, differential diagnosis with basal cell adenocarcinoma, adenoid cystic carcinoma and basaloid squamous cell carcinoma is mandatory.
  • We describe a case of basal cell adenoma of the parotid gland.
  • We also review the literature and discuss the diagnosis and management of this rare entity.
  • [MeSH-major] Adenoma / pathology. Parotid Neoplasms / pathology

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  • (PMID = 16505803.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 21
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67. Koch M, Bozzato A, Iro H, Zenk J: Combined endoscopic and transcutaneous approach for parotid gland sialolithiasis: indications, technique, and results. Otolaryngol Head Neck Surg; 2010 Jan;142(1):98-103
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  • [Title] Combined endoscopic and transcutaneous approach for parotid gland sialolithiasis: indications, technique, and results.
  • OBJECTIVE: Despite all the advances of minimally invasive surgery, refractory stones remain in 10 to 20 percent of all cases of parotid gland sialolithiasis, and persistence of the symptoms makes removal of the gland inevitable.
  • In some of these cases, however, it may be possible to conserve the gland using a combination of endoscopic and transcutaneous procedures.
  • CONCLUSION: The combined operation offers a further option for gland-conserving treatment in cases with obstructive salivary gland disease, especially sialolithiasis.
  • The gland resection rate can thus be further reduced.
  • [MeSH-major] Endoscopy. Parotid Gland / surgery. Salivary Gland Calculi / surgery

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  • (PMID = 20096231.001).
  • [ISSN] 1097-6817
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. Emerick KS, Fabian RL, Deschler DG: Clinical presentation, management, and outcome of high-grade mucoepidermoid carcinoma of the parotid gland. Otolaryngol Head Neck Surg; 2007 May;136(5):783-7
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  • [Title] Clinical presentation, management, and outcome of high-grade mucoepidermoid carcinoma of the parotid gland.
  • OBJECTIVE: To describe clinical features of high-grade (HG) mucoepidermoid carcinoma (MEC) of the parotid gland and assess clinical outcomes of one surgical management approach.
  • Pathology records were reviewed from 1977 to 1997, identifying patients with parotid HG MEC.
  • CONCLUSION: High-grade MEC of the parotid gland is an aggressive disease that frequently presents at advanced stage.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Carcinoma, Mucoepidermoid / surgery. Neoplasm Staging. Parotid Neoplasms / pathology. Parotid Neoplasms / surgery

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  • (PMID = 17478216.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. Kruse-Lösler B, Presser D, Metze D, Joos U: Surgical reconstruction after subtotal ear resection in malignant melanoma of the ear. J Eur Acad Dermatol Venereol; 2006 Feb;20(2):190-6
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  • Because of a metastasis-suspect lymph node in the parotid gland, surgery included asservation of the sentinel lymph node, neck dissection and parotidectomy.
  • [MeSH-major] Melanoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Ear, External / pathology. Ear, External / surgery. Humans. Lymphatic Metastasis. Male. Neoplasm Metastasis. Parotid Gland / surgery. Reconstructive Surgical Procedures

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  • (PMID = 16441630.001).
  • [ISSN] 0926-9959
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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70. Koch M, Zenk J, Iro H: Long-term results of morbidity after parotid gland surgery in benign disease. Laryngoscope; 2010 Apr;120(4):724-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term results of morbidity after parotid gland surgery in benign disease.
  • OBJECTIVES/HYPOTHESIS: To determine the incidence of major and minor complications and their impact on patients' comfort after parotid surgery in benign disease.
  • These data suggest that less invasive operative techniques should be considered in case of a benign disease.
  • [MeSH-major] Facial Paralysis / epidemiology. Otorhinolaryngologic Surgical Procedures / adverse effects. Parotid Diseases / surgery. Sweating, Gustatory / epidemiology

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  • (PMID = 20205175.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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71. Wang WH, Wang CY, Bian L, Xia B, Hu YY, Xu B: [Study about the clinical and pathological characteristics of salivary duct carcinoma]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2010 Apr;28(2):128-31
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  • OBJECTIVE: To investigate the clinical and pathological characteristics of salivary duct carcinoma (SOC) so as to provide basis for the diagnosis and therapy of SOC.
  • Meanwhile, eight tumor specimens were examined for vascular endothelial growth factor (VEGF), cytokeratin (CK), gross cystic disease fluid protein (CC DFP)-15, androgen receptor (AR) and oncogene C-erBb-2 protein expression via immunohistochemistry.
  • RESULTS: Of the eight patients with SOC, five tumors grew in the parotid gland, the majority of the patients had facial nerve paralysis, three had recurrence.
  • GCDFP-15, AR and C-erBb--2 may play an important role in pathological diagnosis for SOC.
  • [MeSH-minor] Carcinoma. Carcinoma, Squamous Cell. Carrier Proteins. Glycoproteins. Head and Neck Neoplasms. Humans. Immunohistochemistry. Receptor, ErbB-2. Receptors, Androgen. Retrospective Studies. Salivary Gland Neoplasms

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  • (PMID = 20480651.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / AR protein, human; 0 / Carrier Proteins; 0 / Glycoproteins; 0 / PIP protein, human; 0 / Receptors, Androgen; 0 / Vascular Endothelial Growth Factor A; EC 2.7.10.1 / Receptor, ErbB-2; Carcinoma, squamous cell of head and neck
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72. Syebele K: Regression of both oral mucocele and parotid swellings, following antiretroviral therapy. Int J Pediatr Otorhinolaryngol; 2010 Jan;74(1):89-92
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  • [Title] Regression of both oral mucocele and parotid swellings, following antiretroviral therapy.
  • HIV-salivary gland associated disease is a well accepted concept in the HIV-related literature.
  • Parotid swellings, especially in its cystic benign lymphoepithelial form, have been largely reported.
  • The mainstream treatment of most of parotid pathologies and oral mucoceles remains surgical approach.
  • Strong evidences do, however, exist about lymphopithelial lesions of parotid glands that have been successfully treated with antiretroviral drugs.
  • We present a case of intraoral mucocele, coexisting with bilateral parotid gland lymphoepithelial lesions, on a 2-year-old HIV-positive patient.
  • Both parotid gland swellings and the sublingual mucocele have completely regressed following antiretroviral therapy.
  • Conversely to benign lymphoepithelial lesions of parotid glands, the regression of oral mucocele on HIV-positive patient, following antiretroviral drugs therapy appears to be a rare phenomenon.
  • [MeSH-major] Anti-Retroviral Agents / therapeutic use. Mouth Mucosa / pathology. Mucocele. Parotid Diseases / complications

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  • [Copyright] Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19879006.001).
  • [ISSN] 1872-8464
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Anti-Retroviral Agents; 0 / Antigens, CD4
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73. Petropoulos IK, Zuber JP, Guex-Crosier Y: Heerfordt syndrome with unilateral facial nerve palsy: a rare presentation of sarcoidosis. Klin Monbl Augenheilkd; 2008 May;225(5):453-6
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  • BACKGROUND: Heerfordt syndrome is rare and is characterized by fever, uveitis, parotid gland enlargement, and facial nerve palsy.
  • Examination revealed mild anterior uveitis OU, mild vitritis OD, fundus whitish lesions OU, left otalgia, taste disorders, bilateral parotid gland enlargement, and left facial nerve palsy.
  • Work-up for infection or tumour was negative.
  • Chest computed tomography and transbronchial lymph node biopsy set the diagnosis of sarcoidosis.
  • CONCLUSIONS: Heerfordt syndrome is a rare manifestation of neurosarcoidosis and has to be included in the differential diagnosis of facial nerve palsy.
  • [MeSH-major] Facial Nerve Diseases / diagnosis. Facial Paralysis / diagnosis. Uveoparotid Fever / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Rare Diseases / diagnosis

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  • (PMID = 18454397.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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74. Kikuchi Y, Hirota M, Iwai T, Aoki S, Chikumaru H, Kawabe R, Matsui Y: Salivary duct carcinoma in the mandible: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Mar;103(3):e41-6
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  • Salivary duct carcinoma (SDC) is a distinctive and aggressive neoplasm.
  • The most frequent site of origin is the parotid gland, followed by the submandibular gland.
  • In this report, we also discuss the specific diagnostic criteria and developmental theories of intraosseous salivary gland tumors.
  • [MeSH-major] Mandibular Neoplasms / pathology. Salivary Ducts / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 17321438.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Willenborg KM, Götz F, Klein R, Lenarz T, Stöver T: [Tuberculosis in the parotid gland in HIV infection]. Laryngorhinootologie; 2008 Jun;87(6):420-2
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  • [Title] [Tuberculosis in the parotid gland in HIV infection].
  • [Transliterated title] Tuberkulose in der Glandula parotidea bei HIV-Infektion.
  • A 35-year-old man with HIV-infection presented with a progressive swelling of the left parotid gland lasting for 3 months.
  • Physical examination revealed a firm mass on the tail of the parotid gland.
  • Ultrasound examination of the left parotid showed a well-circumscribed round lesion.
  • MR imaging demonstrated a 2 cm lesion in the ventral subcutaneous part of the parotid gland.
  • Primary tuberculosis of the parotid gland in a patient with HIV-infection was diagnosed and anti-mycobacterial therapy was started.
  • In HIV-patients with unilateral swelling of the parotid gland, tuberculosis should be considered in the differential diagnosis of pleomorphic adenoma and fine needle aspiration cytology should be performed to avoid unnecessary surgery.
  • [MeSH-major] AIDS-Related Opportunistic Infections / diagnosis. Parotid Diseases / diagnosis. Tuberculosis / diagnosis
  • [MeSH-minor] Adult. Antitubercular Agents / therapeutic use. Combined Modality Therapy. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Parotid Gland / pathology. Parotid Gland / surgery. Ultrasonography

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  • (PMID = 18288625.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antitubercular Agents
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76. Hansen A, Dörner T: [Sjögren syndrome]. Internist (Berl); 2010 Oct;51(10):1267-79; quiz 1280
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  • Sjögren's syndrome (SS) is a chronic inflammatory disorder of hitherto unknown origin.
  • Sicca symptoms and/or recurrent parotid gland swelling are often accompanied by fatigue.
  • [MeSH-major] Sjogren's Syndrome / diagnosis
  • [MeSH-minor] Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Antibodies, Antinuclear / blood. Biological Products / therapeutic use. Combined Modality Therapy. Cross-Sectional Studies. Diagnosis, Differential. Female. Glucocorticoids / therapeutic use. Humans. Immunosuppressive Agents / therapeutic use. Infant, Newborn. Lymphoma, B-Cell / diagnosis. Lymphoma, B-Cell / epidemiology. Lymphoma, B-Cell / therapy. Male. Pregnancy. Prenatal Diagnosis. Prognosis. Risk Factors

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  • (PMID = 20821183.001).
  • [ISSN] 1432-1289
  • [Journal-full-title] Der Internist
  • [ISO-abbreviation] Internist (Berl)
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Antibodies, Antinuclear; 0 / Biological Products; 0 / Glucocorticoids; 0 / Immunosuppressive Agents
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77. Chen WL, Yang ZH, Li JS, Huang ZQ, Wang JG, Zhang B: [Plastic surgical treatment of extensive hemangiomas in the oral and maxillofacial regions in children]. Zhonghua Zheng Xing Wai Ke Za Zhi; 2005 Nov;21(6):461-3
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  • The location of hemangiomas included parotid gland (39.6%), lip (20.9%), buccal (20.1%), suborbital (9%), orbital (7.5%) and nasal region (3%).

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  • (PMID = 16463788.001).
  • [ISSN] 1009-4598
  • [Journal-full-title] Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery
  • [ISO-abbreviation] Zhonghua Zheng Xing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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78. Terashima K, Shioyama Y, Nakamura K, Ohga S, Nomoto S, Yamaguchi T, Toba T, Yoshitake T, Yabuuchi H, Nakashima T, Terashima H, Honda H: Long-term local control of recurrent adenoid cystic carcinoma in the parotid gland with radiotherapy and intraarterial infusion chemotherapy. Radiat Med; 2006 May;24(4):287-91
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  • [Title] Long-term local control of recurrent adenoid cystic carcinoma in the parotid gland with radiotherapy and intraarterial infusion chemotherapy.
  • We report a case of postoperative recurrence of adenoid cystic carcinoma in the left parotid gland treated with radiotherapy and arterial infusion chemotherapy.
  • A 52-year-old woman had a history of surgical resection for an adenoid cystic carcinoma arising from the left parotid gland 25 years before.
  • Despite two reoperations for local recurrence after the initial surgery, she had a third local recurrence in the remnant of the left parotid gland.
  • [MeSH-major] Carboplatin / administration & dosage. Carcinoma, Adenoid Cystic / drug therapy. Carcinoma, Adenoid Cystic / radiotherapy. Neoplasm Recurrence, Local / prevention & control. Parotid Neoplasms / therapy

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  • (PMID = 16958403.001).
  • [ISSN] 0288-2043
  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; BG3F62OND5 / Carboplatin
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79. Kuhnt T, Janich M, Götz U, Gerlach R, Chiricuta IC, Hänsgen G: [Presentation of a 3D conformal radiotherapy technique for head-and-neck tumors resulting in substantial protection of the parotid glands]. Strahlenther Onkol; 2006 Jun;182(6):325-30
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  • [Title] [Presentation of a 3D conformal radiotherapy technique for head-and-neck tumors resulting in substantial protection of the parotid glands].
  • PURPOSE: The aim of this study was to improve the irradiation technique for the treatment of head-and-neck tumors and, in particular, to make use of the advantages found in modern 3D planning to protect the parotid glands.
  • The sum doses D(min), D(max) and D(mean) for PTV, boost volume, and ipsilateral and contralateral parotid gland were evaluated, and the time needed for calculation of the plans was also determined.
  • Significant differences were found regarding the three different techniques, e.g., for the ipsilateral parotid gland D(min) (T1 = 47.4, T2 = 50.6, and T3 = 38.4 Gy) as well as for the contralateral parotid gland D(min) (T1 = 42.1, T2 = 44.2, and T3 = 17.8 Gy) and D(mean) (T1 = 51.3, T2 = 52.8, and T3 = 32.6 Gy).
  • This was especially the case with regard to the contralateral parotid gland, when the dose distributions were calculated equally for PTV and boost volume.
  • In this study, the D(mean) dose of the contralateral parotid gland was lower than the TD(50) of 37 Gy (95% confidence interval 32-43 Gy) previously assumed by the authors.
  • Therefore, it can be concluded that in the present study a more intensive protection of this gland and a reduction in xerostomia were possibly obtained.
  • [MeSH-major] Head and Neck Neoplasms / radiotherapy. Parotid Diseases / prevention & control. Radiation Injuries / prevention & control. Radiation Protection / methods. Radiotherapy Planning, Computer-Assisted / methods. Radiotherapy, Conformal / adverse effects. Radiotherapy, Conformal / methods

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  • (PMID = 16703287.001).
  • [ISSN] 1439-099X
  • [Journal-full-title] Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
  • [ISO-abbreviation] Strahlenther Onkol
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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80. Betka J, Chovanec M, Klozar J, Taudy M, Plzák J, Kodetová D, Lisý J: Transoral and combined transoral-transcervical approach in the surgery of parapharyngeal tumors. Eur Arch Otorhinolaryngol; 2010 May;267(5):765-72
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  • The goal of parapharyngeal space (PPS) tumor surgery is to obtain adequate visualization to ensure complete removal with preservation of the surrounding nerves and vessels.
  • Transoral approach is the most controversial one due to cited limited exposure, risk of tumor spillage, and possibility of neurovascular injury.
  • Majority of treated tumors were pleomorphic adenomas (14 minor salivary gland and 7 deep lobe parotid gland tumors).
  • Two cases of malignant salivary gland tumors, 4 nerve sheath tumors and 1 lymphangioma were also excised.
  • Mean tumor size was 6.1 cm (range 2-11 cm).
  • It can be combined with external approach to achieve safe resection of some benign tumors which would need transmandibular approach.
  • [MeSH-minor] Female. Humans. Male. Mouth. Neck. Neoplasm Staging. Nerve Sheath Neoplasms / surgery. Salivary Gland Neoplasms / surgery

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  • (PMID = 19714351.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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81. Suh SI, Seol HY, Kim TK, Lee NJ, Kim JH, Kim KA, Woo JS, Lee JH: Acinic cell carcinoma of the head and neck: radiologic-pathologic correlation. J Comput Assist Tomogr; 2005 Jan-Feb;29(1):121-6
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  • RESULTS: The lesions in the superficial lobe of the parotid gland were solid (n=7), cystic (n=1), and cystic mass with mural nodule (n=1) on CT.
  • A parapharyngeal lesion was cystic mass with mural nodule, and a submandibular and a palate tumor were cystic lesions on CT.
  • All solid masses in the parotid gland (n=7) included focal low-attenuating portions on CT, which were microcyst, hemorrhage, or necrosis on pathologic examination.
  • Internal hemorrhage on the MR images was seen in a parapharyngeal and a parotid lesion.
  • CONCLUSION: Although ACC appears to have nonspecific imaging findings, familiarity with some imaging features can be helpful for differential diagnosis of head and neck tumors.
  • [MeSH-minor] Adult. Aged. Child, Preschool. Diagnosis, Differential. Female. Hemorrhage / pathology. Hemorrhage / radiography. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Necrosis. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / radiography. Palatal Neoplasms / pathology. Palatal Neoplasms / radiography. Parotid Neoplasms / pathology. Parotid Neoplasms / radiography. Pharyngeal Neoplasms / pathology. Pharyngeal Neoplasms / radiography. Retrospective Studies. Submandibular Gland Neoplasms / pathology. Submandibular Gland Neoplasms / radiography. Tomography, X-Ray Computed

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  • (PMID = 15665697.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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82. Fiorella R, Di Nicola V, Fiorella ML, Spinelli DA, Coppola F, Luperto P, Madami L: Major salivary gland diseases. Multicentre study. Acta Otorhinolaryngol Ital; 2005 Jun;25(3):182-90
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  • [Title] Major salivary gland diseases. Multicentre study.
  • This multicentre study involved 28 Italian ORL Centres responding to a questionnaire sent by us which allowed recruitment of a high large number of cases of parotid neoplasms observed over a 10-year period.
  • Benign tumours account for 80% of case histories with a relationship 1:4 M/F, the most frequent being pleomorphic adenoma (57.3% of cases), followed by Warthin's tumour (32.4%), this rating not having been confirmed in case histories (8-10%) in the literature.
  • Surgical treatment of benign tumours consisted, in 50% of cases, in superficial paroditectomy and in approximately 30% of total paroditectomy.
  • When no clinically evident lymph nodes were present (NO) considering the tumour histotype, two thirds of patients underwent surgery or radiotherapy, while in the remainder the wait-and-see attitude was prefered.
  • Oncological results obtained were compared with those reported in the literature: in fact for all benign neoplasms relapse ratings are about 5%, while for malignant tumours the worst prognosis was in squamous cell carcinoma with median of 37.7 on survival and metastasis rate of 16.5%.
  • [MeSH-major] Salivary Gland Neoplasms
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Neoplasm Staging. Otorhinolaryngologic Surgical Procedures. Surveys and Questionnaires

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  • (PMID = 16450775.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2639866
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83. Kumánovics A, Perkins SL, Gilbert H, Cessna MH, Augustine NH, Hill HR: Diffuse large B cell lymphoma in hyper-IgE syndrome due to STAT3 mutation. J Clin Immunol; 2010 Nov;30(6):886-93
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  • With the discovery of mutations in the STAT3 gene in the majority of autosomal dominant cases, it is now possible to make a molecular diagnosis of hyper-IgE syndrome.
  • Here, we report of a 48-year-old male with hyper-IgE syndrome who developed a primary parotid gland diffuse large B cell lymphoma.
  • Analysis for STAT3 mutations demonstrated that the causal mutation of hyper-IgE syndrome, R382Q, arose de novo in the patient and it was transmitted to three of his five children, all three of whom are clinically affected.

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  • (PMID = 20859667.001).
  • [ISSN] 1573-2592
  • [Journal-full-title] Journal of clinical immunology
  • [ISO-abbreviation] J. Clin. Immunol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / STAT3 Transcription Factor
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84. Gao N, Li Y, Li LJ, Wen YM: Clinical analysis of head and neck cancer cases in south-west China 1953 - 2002. J Int Med Res; 2009 Jan-Feb;37(1):189-97
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  • The parotid gland and palate were the most common locations for salivary gland tumours.

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  • (PMID = 19215690.001).
  • [ISSN] 0300-0605
  • [Journal-full-title] The Journal of international medical research
  • [ISO-abbreviation] J. Int. Med. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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85. Casserly P, Kiely P, Fenton JE: Cervical sympathetic chain schwannoma masquerading as a carotid body tumour with a postoperative complication of first-bite syndrome. Eur Arch Otorhinolaryngol; 2009 Oct;266(10):1659-62
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  • [Title] Cervical sympathetic chain schwannoma masquerading as a carotid body tumour with a postoperative complication of first-bite syndrome.
  • The patient had a postoperative complication of first-bite syndrome (FBS).Although rare, CSCS should be considered in the differential diagnosis for tumours at the carotid bifurcation.
  • Damage to the sympathetic innervation to the parotid gland can result in severe postoperative pain characterised by FBS and should be considered in all patients undergoing surgery involving the parapharyngeal space.
  • [MeSH-major] Autonomic Nervous System Diseases / diagnosis. Carotid Body Tumor / diagnosis. Head and Neck Neoplasms / diagnosis. Horner Syndrome / etiology. Neurilemmoma / diagnosis. Peripheral Nervous System Neoplasms / diagnosis. Postoperative Complications / etiology
  • [MeSH-minor] Carotid Artery, External / pathology. Carotid Artery, Internal / pathology. Diagnosis, Differential. Female. Humans. Jugular Veins / pathology. Magnetic Resonance Angiography. Magnetic Resonance Imaging. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 19130071.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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86. Ferreira PC, Amarante JM, Rodrigues JM, Pinho CJ, Cardoso MA, Reis JC: Parotid surgery: review of 107 tumors (1990-2002). Int Surg; 2005 Jul-Aug;90(3):160-6
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  • [Title] Parotid surgery: review of 107 tumors (1990-2002).
  • Tumors of the parotid gland are uncommon.
  • We reviewed the clinical and the surgical records of a series of 109 patients who were recommended for surgery because of parotid tumors by the Plastic and Reconstructive Service of São João Hospital, Portugal, between 1990 and 2002.
  • The following parameters were evaluated: age, sex, gland afflicted, symptoms, and duration of symptoms, diagnostic procedures, treatment methods, follow-up, and recurrences.
  • Pleomorphic adenoma was the most common tumor (63.5%).
  • [MeSH-major] Parotid Gland / surgery. Parotid Neoplasms / surgery

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  • (PMID = 16466006.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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87. Kropf N, Cordeiro CN, McCarthy CM, Hu QY, Cordeiro PG: The vertically oriented free myocutaneous gracilis flap in head and neck reconstruction. Ann Plast Surg; 2008 Dec;61(6):632-6
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  • Seven patients had a malignant skin tumor; 3 patients had a parotid gland tumor.

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  • (PMID = 19034078.001).
  • [ISSN] 1536-3708
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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88. Kawashima Y, Sumi T, Sugimoto T, Kishimoto S: First-bite syndrome: a review of 29 patients with parapharyngeal space tumor. Auris Nasus Larynx; 2008 Mar;35(1):109-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] First-bite syndrome: a review of 29 patients with parapharyngeal space tumor.
  • METHODS: A total of 29 consecutive patients treated with a surgical resection for parapharyngeal space tumor between April 1999 and April 2005 were retrospectively reviewed.
  • CONCLUSION: The present findings strongly indicate that loss of sympathetic innervation to the parotid gland from the superior cervical ganglion causes first-bite syndrome.
  • [MeSH-major] Deglutition Disorders / physiopathology. Hyperalgesia / physiopathology. Parotid Gland / innervation. Pharyngeal Neoplasms / surgery. Postoperative Complications / physiopathology. Superior Cervical Ganglion / surgery


89. Zbären P, Stauffer E: Pleomorphic adenoma of the parotid gland: histopathologic analysis of the capsular characteristics of 218 tumors. Head Neck; 2007 Aug;29(8):751-7
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  • [Title] Pleomorphic adenoma of the parotid gland: histopathologic analysis of the capsular characteristics of 218 tumors.
  • METHODS: Retrospective (n = 154) and prospective (n = 64) histologic analysis of the capsular characteristics such as incompleteness, tumor penetration, pseudopodia, and satellite tumors of 218 pleomorphic adenomas.
  • If left in the surrounding salivary gland tissue at surgery, they can lead to recurrences of pleomorphic adenomas of the parotid gland.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Neoplasm Staging. Prospective Studies. Retrospective Studies. Treatment Outcome

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  • (PMID = 17252593.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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90. Chan WH, Lee KW, Chiang FY, Ho KY, Chai CY, Kuo WR: Features of parotid gland diseases and surgical results in southern Taiwan. Kaohsiung J Med Sci; 2010 Sep;26(9):483-92
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  • [Title] Features of parotid gland diseases and surgical results in southern Taiwan.
  • Various parotid gland diseases are seen clinically, including inflammation, sialolithiasis, and benign and malignant tumors.
  • It is important to differentiate between these to make a correct diagnosis and for proper management.
  • Here, we investigated the relationship between tumor characteristics and pathology, and considered whether the former could be used to differentiate malignant from benign parotid gland diseases.
  • Two hundred and eighty-one patients (88.9%) had benign disease, and 35 (11.1%) had malignant disease.
  • The most common benign disease was pleomorphic adenoma (115 cases, 36.4%), but the most common disease in male patients was Warthin's tumor, a finding which, as far as we aware, has not been previously been reported in the literature.
  • The incidence of Warthin's tumor seems to be increasing.
  • Compared with benign disease, malignant parotid gland disease more often presents as a hard, painful, fixed and large mass (> 3 cm), and more often involves the deep lobe of the parotid gland.
  • However, there was no difference in transient facial palsy rate between benign and malignant parotid gland disease, although parotid gland cancer had a higher incidence of permanent facial palsy postoperatively.
  • [MeSH-major] Parotid Diseases / pathology. Parotid Diseases / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Parotid Gland / pathology. Parotid Gland / surgery. Postoperative Complications / epidemiology. Retrospective Studies. Taiwan / epidemiology. Treatment Outcome. Young Adult

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  • [Copyright] Copyright © 2010 Elsevier. Published by Elsevier B.V. All rights reserved.
  • [CommentIn] Kaohsiung J Med Sci. 2012 Jun;28(6):350-1 [22632893.001]
  • (PMID = 20837345.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China (Republic : 1949- )
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91. Braam PM, Roesink JM, Moerland MA, Raaijmakers CP, Schipper M, Terhaard CH: Long-term parotid gland function after radiotherapy. Int J Radiat Oncol Biol Phys; 2005 Jul 1;62(3):659-64
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  • [Title] Long-term parotid gland function after radiotherapy.
  • PURPOSE: Irradiation of the parotid glands causes salivary dysfunction, resulting in reduced salivary flow.
  • The objective of this study was to analyze the long-term parotid gland function after irradiation for head-and-neck cancer.
  • Stimulated bilateral parotid salivary flow rates were measured before RT and 6 weeks, 6 months, 12 months, and at least 3.5 years after RT completion.
  • A complication was defined as a stimulated parotid flow rate of <25% of the pre-RT flow rate.
  • RESULTS: The mean stimulated flow rate of the parotid glands before RT was 0.31 mL/min (standard deviation [SD], 0.21).
  • The mean dose to the parotid gland resulting in a 50% complication probability increased from 34 Gy at 6 weeks to 40 Gy at 6 months, 42 Gy at 12 months, and 46 Gy at 5 years after RT.
  • [MeSH-major] Head and Neck Neoplasms / radiotherapy. Parotid Gland / radiation effects. Salivation / radiation effects

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  • (PMID = 15936542.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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92. Vázquez Mahía I, López-Cedrún Cembranos JL, Ferreras Granado J, Lorenzo Franco F: Temporomandibular juxtaarticular chondroma: case report. Med Oral Patol Oral Cir Bucal; 2007 Mar;12(2):E171-4
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  • Chondromas are benign tumours composed of mature hyaline cartilage.
  • We present here the first case in the English language medical literature of juxtaarticular chondroma of the temporomandibular joint in the parotid region.
  • The patient, a 54 year old woman, presented a right preauricular tumour of 3.5 cm. which had been developing for 4 years.
  • The diagnostic possibilities of a parotid pleomorphic adenoma and of a cartilage tumour of the TMJ suggested a difficult preoperative differential diagnosis, which influenced our approach regarding therapy.
  • The tumour was excised, preserving the parotid gland.
  • This enabled us to confirm the histological diagnosis of chondroma, composed solely of chondroide tissue.
  • [MeSH-major] Chondroma / pathology. Parotid Neoplasms / pathology. Temporomandibular Joint

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  • (PMID = 17322809.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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93. Zheng C, Nikolov NP, Alevizos I, Cotrim AP, Liu S, McCullagh L, Chiorini JA, Illei GG, Baum BJ: Transient detection of E1-containing adenovirus in saliva after the delivery of a first-generation adenoviral vector to human parotid gland. J Gene Med; 2010 Jan;12(1):3-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transient detection of E1-containing adenovirus in saliva after the delivery of a first-generation adenoviral vector to human parotid gland.
  • One week after the administration of AdhAQP1 to an enrolled, generally healthy patient, E1-containing adenovirus was detected in parotid saliva.
  • RESULTS: On day 7 after AdhAQP1 delivery, low levels of the Ad5 E1 gene were detected in parotid saliva (82 copies/microl).
  • The patient was asymptomatic and subsequent analysis of parotid saliva samples prior to day 7 and after day 7 until day 42 was negative for both virus and vector.
  • Detailed PCR analyses of DNA extracted from the day 7 parotid saliva sample suggested the absence of a recombination event, and no infectious virus was found.
  • CONCLUSIONS: The patient most likely had a latent Ad5 infection in the targeted parotid gland that was activated after gene transfer and was without clinical consequence.
  • [MeSH-major] Adenoviridae / genetics. Adenovirus E1 Proteins / genetics. Gene Transfer Techniques. Genetic Vectors / administration & dosage. Genetic Vectors / genetics. Parotid Gland / metabolism. Saliva / metabolism

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  • (PMID = 19941317.001).
  • [ISSN] 1521-2254
  • [Journal-full-title] The journal of gene medicine
  • [ISO-abbreviation] J Gene Med
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 DE000336-27; United States / Intramural NIH HHS / /
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adenovirus E1 Proteins; 0 / DNA, Viral; 146410-94-8 / Aquaporin 1
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94. Price C, Schmidt MA, Adam EJ, Lacey H: Parotid gland enlargement in eating disorders: an insensitive sign? Eat Weight Disord; 2008 Dec;13(4):e79-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parotid gland enlargement in eating disorders: an insensitive sign?
  • OBJECTIVE: To study, using magnetic resonance imaging (MRI), the parotid glands of patients who self-induce vomiting and in particular to observe the effects of cessation of this behaviour.
  • The morphological features and composition of enlarged parotid glands in this group, compared with normal controls, were also examined.
  • METHOD: MRI scans of the parotid glands were performed on 5 controls and 5 subjects with a purging form of eating disorder, at cessation of vomiting and 6 to 9 weeks later.
  • RESULTS: Parotid volumes are accurately measured using MRI.
  • CONCLUSION: Absence of salivary gland enlargement does not exclude significant vomiting behaviour and clinicians should remain alert to the possibility of undisclosed vomiting.
  • [MeSH-major] Feeding and Eating Disorders / complications. Feeding and Eating Disorders / diagnosis. Parotid Gland / pathology. Vomiting / diagnosis
  • [MeSH-minor] Adult. Aged. Anorexia Nervosa / complications. Anorexia Nervosa / diagnosis. Body Height. Body Mass Index. Body Weight. Bulimia Nervosa / complications. Bulimia Nervosa / diagnosis. Case-Control Studies. Female. Humans. Hypertrophy / etiology. Magnetic Resonance Imaging. Middle Aged. Predictive Value of Tests. Sensitivity and Specificity. Time Factors

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  • (PMID = 19169067.001).
  • [ISSN] 1590-1262
  • [Journal-full-title] Eating and weight disorders : EWD
  • [ISO-abbreviation] Eat Weight Disord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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95. Safioleas M, Giannopoulos A, Manti Ch, Stamatakos M, Safioleas K, Stavrou E: Hydatid disease of the parotid gland: a rare case report. Parasitol Int; 2007 Sep;56(3):247-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hydatid disease of the parotid gland: a rare case report.
  • A 40-year-old female suffering from hydatid disease located in the parotid gland is presented.
  • [MeSH-major] Echinococcosis. Parotid Diseases
  • [MeSH-minor] Adult. Albendazole / therapeutic use. Anthelmintics / therapeutic use. Female. Humans. Parotid Gland / parasitology. Parotid Gland / surgery. Treatment Outcome

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  • (PMID = 17400021.001).
  • [ISSN] 1383-5769
  • [Journal-full-title] Parasitology international
  • [ISO-abbreviation] Parasitol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anthelmintics; F4216019LN / Albendazole
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96. Yanardag H: Parotid gland involvement in sarcoidosis. South Med J; 2005 Feb;98(2):258-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parotid gland involvement in sarcoidosis.
  • [MeSH-major] Parotid Diseases / complications. Parotid Gland / pathology. Sarcoidosis / complications

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  • (PMID = 15759966.001).
  • [ISSN] 0038-4348
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] United States
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97. Chakraborty PP, Bhattacharjee R, Chatterjee K: Parotid gland cysticercosis. J Assoc Physicians India; 2007 Oct;55:717
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parotid gland cysticercosis.
  • [MeSH-major] Brain Edema / pathology. Neurocysticercosis / pathology. Parotid Diseases / pathology. Parotid Gland / pathology

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  • (PMID = 18173024.001).
  • [ISSN] 0004-5772
  • [Journal-full-title] The Journal of the Association of Physicians of India
  • [ISO-abbreviation] J Assoc Physicians India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] F4216019LN / Albendazole
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98. Brandling-Bennett HA, Metry DW, Baselga E, Lucky AW, Adams DM, Cordisco MR, Frieden IJ: Infantile hemangiomas with unusually prolonged growth phase: a case series. Arch Dermatol; 2008 Dec;144(12):1632-7
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  • All of the IHs had a deep dermal to subcutaneous component, all had either segmental or indeterminate morphologic characteristics, and 39% involved the parotid gland.

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  • [CommentIn] Arch Dermatol. 2008 Dec;144(12):1650 [19075153.001]
  • (PMID = 19075148.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Interferon-alpha; 0 / Recombinant Proteins; 5J49Q6B70F / Vincristine; 76543-88-9 / interferon alfa-2a; 9008-11-1 / Interferons; 99210-65-8 / interferon alfa-2b
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99. Orhan KS, Demirel T, Kocasoy-Orhan E, Yenigül K: Facial paralysis due to an occult parotid abscess. Kulak Burun Bogaz Ihtis Derg; 2008 Mar-Apr;18(2):115-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Facial paralysis due to an occult parotid abscess.
  • Facial paralysis associated with benign diseases of the parotid gland is very rare.
  • It has been reported in approximately 16 cases of acute suppurative parotitis or parotid abscess.
  • We presented a 45-year-old woman who developed facial paralysis secondary to an occult parotid abscess.
  • The lesion was diagnosed as an occult parotid abscess.
  • [MeSH-major] Abscess / complications. Facial Paralysis / etiology. Parotid Diseases / complications
  • [MeSH-minor] Bell Palsy / diagnosis. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Middle Aged. Parotitis / complications. Parotitis / diagnosis. Parotitis / surgery

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  • (PMID = 18628648.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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100. Mandel L, Wolinsky B, Chalom EC: Treatment of refractory sarcoidal parotid gland swelling in a previously reported unresponsive case. J Am Dent Assoc; 2005 Sep;136(9):1282-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of refractory sarcoidal parotid gland swelling in a previously reported unresponsive case.
  • BACKGROUND: Sarcoidosis is a multisystem granulomatous disease that is seen occasionally in patients with characteristic bilateral parotid gland swelling.
  • CASE DESCRIPTION: The authors describe a previously published case report of a patient with sarcoidosis with parotid gland swellings who did not respond to standard therapy.
  • CLINICAL IMPLICATIONS: It is important for dental practitioners to be familiar with manifestations of sarcoidosis, particularly its salivary gland aspects.
  • [MeSH-major] Immunosuppressive Agents / therapeutic use. Parotid Diseases / drug therapy. Sarcoidosis / drug therapy. Tumor Necrosis Factor-alpha / immunology

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  • (PMID = 16196234.001).
  • [ISSN] 0002-8177
  • [Journal-full-title] Journal of the American Dental Association (1939)
  • [ISO-abbreviation] J Am Dent Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Immunosuppressive Agents; 0 / Tumor Necrosis Factor-alpha; B72HH48FLU / Infliximab
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