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1. Kobayashi N, Kubota K, Kato S, Watanabe S, Shimamura T, Kirikoshi H, Saito S, Ueda M, Endo I, Inayama Y, Maeda S, Nakajima A: FOXP3+ regulatory T cells and tumoral indoleamine 2,3-dioxygenase expression predicts the carcinogenesis of intraductal papillary mucinous neoplasms of the pancreas. Pancreatology; 2010;10(5):631-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] FOXP3+ regulatory T cells and tumoral indoleamine 2,3-dioxygenase expression predicts the carcinogenesis of intraductal papillary mucinous neoplasms of the pancreas.
  • A recent study revealed that indoleamine 2,3-dioxygenase (IDO)-mediated tryptophan depletion was able to affect local tumor-infiltrating lymphocytes.
  • The aim of this study was to investigate the clinical significance of the tumor-infiltrating Tregs and tumoral IDO expression during the progression of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas.
  • IDO expression in the tumor was observed in 5 cases with IPMNs (IPMC, n = 1; I-IPMC, n = 4).
  • IDO expression in the tumor was positively correlated with the prevalence of Tregs in IPMNs.
  • IDO expression in the tumor is one of the late-stage phenomena of multistage carcinogenesis of IPMNs.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma, Pancreatic Ductal / pathology. Cell Transformation, Neoplastic / pathology. Forkhead Transcription Factors / metabolism. Indoleamine-Pyrrole 2,3,-Dioxygenase / metabolism. Pancreatic Neoplasms / pathology

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  • [Copyright] Copyright © 2010 S. Karger AG, Basel.
  • (PMID = 21051918.001).
  • [ISSN] 1424-3911
  • [Journal-full-title] Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
  • [ISO-abbreviation] Pancreatology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / FOXP3 protein, human; 0 / Forkhead Transcription Factors; 0 / Indoleamine-Pyrrole 2,3,-Dioxygenase
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2. Detlefsen S, Sipos B, Feyerabend B, Klöppel G: Pancreatic fibrosis associated with age and ductal papillary hyperplasia. Virchows Arch; 2005 Nov;447(5):800-5
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  • [Title] Pancreatic fibrosis associated with age and ductal papillary hyperplasia.
  • Little is known about the frequency, type and pathogenesis of fibrotic changes that may occur in the pancreas of persons without any clinically apparent or macroscopically visible pancreatic disease.
  • We screened pancreas specimens for the presence and pattern of fibrosis, determined the relationship between fibrosis, age, and duct lesions, and studied the fibrogenic mechanisms.
  • In 89 postmortem specimens from persons without any known pancreatic disease (age range 20-86 years), fibrosis was recorded and graded and the patients were divided into two age classes (younger or older than 60 years).
  • In addition, we analyzed the association between ductal papillary hyperplasia [i.e., pancreatic intraepithelial neoplasia type 1B (PanIN-1B)] and fibrotic foci in the pancreatic tissue to determine the potential impact of obliterating duct lesions on pancreatic fibrosis.
  • Finally, we studied the occurrence in the pancreas of myofibroblasts, identified on the basis of their alpha-SMA and desmin positivity, and determined their relationship to the fibrotic foci.
  • Thirty-eight (44%) of 89 pancreata showed scattered foci of lobular fibrosis affecting peripheral lobuli.
  • The "normal" pancreas develops a specific type of focally accentuated fibrosis that is highly age related.
  • [MeSH-major] Aging / pathology. Carcinoma in Situ / complications. Pancreas / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / complications
  • [MeSH-minor] Actins / metabolism. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Female. Fibrosis. Humans. Hyperplasia. Immunohistochemistry. Male. Middle Aged. Precancerous Conditions

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  • (PMID = 16021508.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor
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3. Anhalt H, Bohannon NJ: Insulin patch pumps: their development and future in closed-loop systems. Diabetes Technol Ther; 2010 Jun;12 Suppl 1:S51-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Steady progress is being made toward the development of a so-called "artificial pancreas," which may ultimately be a fully automated, closed-loop, glucose control system comprising a continuous glucose monitor, an insulin pump, and a controller.
  • A major factor propelling artificial pancreas development is the substantial incidence of-and attendant patient, parental, and physician concerns about-hypoglycemia and extreme hyperglycemia associated with current means of insulin delivery for type 1 diabetes mellitus (T1DM).
  • A successful fully automated artificial pancreas would likely reduce the frequency of and anxiety about hypoglycemia and marked hyperglycemia.
  • Patch-pump systems ("patch pumps") are likely to be used increasingly in the control of T1DM and may be incorporated into the artificial pancreas systems of tomorrow.
  • The use of advanced algorithms in the clinical development of closed-loop systems is reviewed along with projected next steps in artificial pancreas development.

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  • (PMID = 20515308.001).
  • [ISSN] 1557-8593
  • [Journal-full-title] Diabetes technology & therapeutics
  • [ISO-abbreviation] Diabetes Technol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hypoglycemic Agents; 0 / Insulin
  • [Other-IDs] NLM/ PMC2924780
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4. Yang L, Liu YF, Liu SR, Wu G, Zhang JL, Meng YM, Shong SW, Li GC: Prevention and treatment of rejection after simultaneous pancreas-kidney transplantation. Chin Med Sci J; 2005 Sep;20(3):210-3
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  • [Title] Prevention and treatment of rejection after simultaneous pancreas-kidney transplantation.
  • OBJECTIVE: To explore methods of preventing and reversing rejection after simultaneous pancreas-kidney (SPK) transplantation.
  • RESULTS: No primary non-functionality of either kidney or pancreas occurred in this series of transplantations.
  • One patient experienced the accelerated rejection, resulting in the resection of the pancreas and kidney grafts because of the failure of conservative therapy.
  • Only the kidney was involved in 35.3% (6/17); and both the pancreas and kidney were involved in 11.8% (2/17).
  • OKT3 (0.5 mg x d(-1)) was administered for 7-10 days in two patients with both renal and pancreas rejection.
  • Monitoring renal function and pancreas exocrine secretion, and reasonable application of immunosuppressants play important roles in the diagnosis and treatment of rejection.

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  • (PMID = 16261897.001).
  • [ISSN] 1001-9294
  • [Journal-full-title] Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih
  • [ISO-abbreviation] Chin. Med. Sci. J.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Immunoglobulin G; 0 / Immunosuppressive Agents; 0 / Muromonab-CD3; 67U96J8P35 / meprednisone; AYI8EX34EU / Creatinine; CUJ2MVI71Y / daclizumab; VB0R961HZT / Prednisone
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5. Tihanyi Z, Luka F, Botos B, Horváth L, Szontagh-Kisházi P, Altorjay A: [Antral ectopic pancreas causing gastric outlet obstruction]. Magy Seb; 2005 Oct;58(5):331-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Antral ectopic pancreas causing gastric outlet obstruction].
  • [Transliterated title] Gyomorürülési zavart okozó antrális ectopiás pancreas.
  • Ectopic pancreas is an uncommon clinical finding.
  • It is rare for heterotopic pancreas tissue to cause symptoms, however every disease of the pancreas may develop in it.
  • The most common sites for ectopic pancreas are the submucosal layer of the stomach and the small intestine.
  • Symptomatic ectopic pancreas usually causes diagnostic difficulties.
  • We performed subtotal gastrectomy because of a submucosal, antral tumour, that caused gastric outlet obstruction.
  • The histological examination verified ectopic pancreas tissue.
  • [MeSH-major] Choristoma. Gastric Outlet Obstruction / etiology. Pancreas. Pyloric Antrum. Stomach Diseases
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Treatment Outcome

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  • (PMID = 16496778.001).
  • [ISSN] 0025-0295
  • [Journal-full-title] Magyar sebészet
  • [ISO-abbreviation] Magy Seb
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
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6. Frystyk J, Ritzel RA, Maubach J, Büsing M, Lück R, Klempnauer J, Schmiegel W, Nauck MA: Comparison of pancreas-transplanted type 1 diabetic patients with portal-venous versus systemic-venous graft drainage: impact on glucose regulatory hormones and the growth hormone/insulin-like growth factor-I axis. J Clin Endocrinol Metab; 2008 May;93(5):1758-66
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  • [Title] Comparison of pancreas-transplanted type 1 diabetic patients with portal-venous versus systemic-venous graft drainage: impact on glucose regulatory hormones and the growth hormone/insulin-like growth factor-I axis.
  • CONTEXT: Pancreas grafts can be drained through the iliac vein (systemic drainage) or the portal vein.
  • OBJECTIVE: We hypothesized that normalization of portal insulin in patients with portal pancreas graft drainage stimulates the GH/IGF-I axis and thereby contributes to glucose control.
  • METHODS: We compared patients after combined kidney and pancreas transplantation with portal drainage (n = 7) to patients with systemic drainage of the pancreas graft (n = 8) and nondiabetic controls (n = 8).
  • CONCLUSION: Portal drainage of pancreatic endocrine secretion in pancreas graft recipients raises IGF-I and lowers GH secretion.
  • [MeSH-major] Diabetes Mellitus, Type 1 / surgery. Human Growth Hormone / physiology. Insulin-Like Growth Factor I / physiology. Pancreas Transplantation

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  • (PMID = 18319317.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / C-Peptide; 0 / Insulin; 0 / Insulin-Like Growth Factor Binding Protein 3; 12629-01-5 / Human Growth Hormone; 67763-96-6 / Insulin-Like Growth Factor I; 9007-92-5 / Glucagon
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7. Smale E, Davison AM, Smith M, Pritchard C: Fatal intra-abdominal haemorrhage following percutaneous endoscopic gastrostomy. BMJ Case Rep; 2009;2009
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A postmortem examination revealed 2.5 litres of blood and bloodstained fluid within the abdominal cavity and a haemorrhagic pancreas.
  • Microscopy of the pancreas showed a defect in a small to medium-sized artery, likely to be a branch of the splenic artery.
  • The cause of death (as per section 1 of the death certificate) was (1a) intra-abdominal haemorrhage, (1b) pancreatic trauma at PEG feeding tube insertion and (1c) dysphagia due to cerebrovascular disease.

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  • (PMID = 21853009.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3027889
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8. Onishi T, Igarashi T, Ichikawa T: [Case of retroperitoneal fibrosis after surgical treatment of autoimmune pancreatitis]. Hinyokika Kiyo; 2009 Sep;55(9):551-4
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  • During the routine follow-up for colon cancer, a swollen pancreas tail was detected on enhanced CT.
  • He received distal pancreatectomy under the diagnosis of pancreas cancer on 4th October, 2007.
  • Pathological diagnosis revealed the autoimmune pancreatitis.
  • He was treated with predonisolone aiming at the diagnosis and/or therapy.
  • Now, it is thought that autoimmune pancreatitis is a systemic sclerosing disease accompanied with extra-pancreatic pathologic changes such as RPF.
  • [MeSH-major] Autoimmune Diseases / complications. Pancreatitis / complications. Retroperitoneal Fibrosis / diagnosis. Retroperitoneal Fibrosis / etiology


9. Li Z, Ruan L, Lin S, Gittes GK: Clock controls timing of mouse pancreatic differentiation through regulation of Wnt- and Notch-based and cell division components. Biochem Biophys Res Commun; 2007 Aug 3;359(3):491-6
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  • [Title] Clock controls timing of mouse pancreatic differentiation through regulation of Wnt- and Notch-based and cell division components.
  • Here we first show that before embryonic circadian rhythms occur, the oscillation (nucleocytoplasmic shuttling) of core circadian gene Clock is tissue-specific and correlated with the state of differentiation during both early development and later pancreas organogenesis.
  • Disruption of Clock as well as Timeless in the embryonic pancreas does not block pancreatic differentiation but alters the balance and maturity of endocrine and exocrine cells.
  • [MeSH-major] Cell Differentiation. Circadian Rhythm / physiology. Pancreas / cytology. Pancreas / metabolism. Receptors, Notch / metabolism. Trans-Activators / metabolism. Wnt Proteins / metabolism

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  • (PMID = 17559809.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Oligonucleotides, Antisense; 0 / Receptors, Notch; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Wnt Proteins; EC 2.3.1.48 / CLOCK Proteins; EC 2.3.1.48 / Clock protein, mouse
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10. Roda O, Chiva C, Espuña G, Gabius HJ, Real FX, Navarro P, Andreu D: A proteomic approach to the identification of new tPA receptors in pancreatic cancer cells. Proteomics; 2006 Apr;6 Suppl 1:S36-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A proteomic approach to the identification of new tPA receptors in pancreatic cancer cells.
  • We have developed a strategy to identify putative tissue-type plasminogen activator (tPA)receptors present in pancreatic cancer cells by affinity capture with tPA-Sepharose followed by 2-DE and MALDI-MS PMF.
  • Proteins pulled down from either total lysates or raft membrane fractions were characterized and compared with those from a total lysate of an endothelial cell line (HUVEC) to identify pancreas-restricted tPA receptors.
  • A total of 31 proteins were found by this approach, including annexin A2, already described as a tPA receptor in pancreas and endothelial cells, other proteins acting as tPA receptors (i.e., enolase, cytokeratins 8 and 18) in other tissues, and additional proteins not previously identified as candidate tPA receptors.
  • [MeSH-major] Pancreatic Neoplasms / metabolism. Proteomics. Receptors, Cell Surface / metabolism. Tissue Plasminogen Activator / metabolism

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  • (PMID = 16544279.001).
  • [ISSN] 1615-9861
  • [Journal-full-title] Proteomics
  • [ISO-abbreviation] Proteomics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Annexin A2; 0 / Receptors, Cell Surface; EC 3.4.21.68 / Tissue Plasminogen Activator
  • [Number-of-references] 36
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11. Burgos FJ, Gómez V, Pascual J, Marcen R, Villafruela JJ, Correa C, Cuevas B, Mampaso F, García-Gonzalez R: Pancreas islet transplantation in the genitourinary tract associated with renal transplantation: an experimental study. Transplant Proc; 2006 Oct;38(8):2585-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pancreas islet transplantation in the genitourinary tract associated with renal transplantation: an experimental study.
  • Conceptually, pancreas islet transplantation (PIT) associated with renal transplantation (RT) should resolve not only chronic renal failure but also diabetes.
  • The mean weight of the pancreatic specimens was 27.8 g (13 to 46).
  • For the first time, the feasibility of the bladder submucosa as an implantation site for pancreas islets was demonstrated.

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  • (PMID = 17098010.001).
  • [ISSN] 0041-1345
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Cohen ND, Shaw JE: Diabetes: advances in treatment. Intern Med J; 2007 Jun;37(6):383-8
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  • Pancreas and islet cell transplantation are the subject of ongoing research, but currently require immunosuppressive treatment regimes.
  • The main limitation is lack of availability of donor pancreases.

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  • (PMID = 17535382.001).
  • [ISSN] 1445-5994
  • [Journal-full-title] Internal medicine journal
  • [ISO-abbreviation] Intern Med J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 35
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13. Pery C, Meurette G, Ansquer C, Frampas E, Regenet N: Role and limitations of 18F-FDG positron emission tomography (PET) in the management of patients with pancreatic lesions. Gastroenterol Clin Biol; 2010 Sep;34(8-9):465-74
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  • [Title] Role and limitations of 18F-FDG positron emission tomography (PET) in the management of patients with pancreatic lesions.
  • Several studies have shown that PET-CT has superior efficacy over conventional imaging techniques in distinguishing a benign pancreatic tumor from a malignant one.
  • It contributes to the diagnosis of cancer in patients with a doubtful mass, much more in case of chronic pancreatitis.
  • PET-CT is also an important help for the diagnosis of cystic tumors of the pancreas; the results can affect the management strategy.
  • The aim of this paper is to summarize the role and limitations of 18-F-FDG PET-CT in the management of patients with pancreatic lesions (adenocarcinoma, cystic tumors, endocrine tumors, etc…) concerning the malignancy diagnosis, the detection of metastases, the monitoring after non surgical treatments and to evaluate interpretation difficulties, particularly in case of diabetes or chronic pancreatitis.
  • [MeSH-major] Fluorodeoxyglucose F18. Pancreatic Neoplasms / radionuclide imaging. Positron-Emission Tomography / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / radionuclide imaging. Cystadenocarcinoma / pathology. Cystadenocarcinoma / radionuclide imaging. Cystadenoma / pathology. Cystadenoma / radionuclide imaging. Humans. Insulinoma / radionuclide imaging. Neoplasm Metastasis / radionuclide imaging. Neoplasm Staging. Pancreatitis / radionuclide imaging. Prognosis

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  • [Copyright] Copyright © 2010. Published by Elsevier Masson SAS.
  • (PMID = 20688444.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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14. Demir MK, Kilicoğlu G, Akinci O: Alveolar hydatid disease of the liver: brief review and spectrum of adjacent organ invasion. Australas Radiol; 2007 Aug;51(4):346-50
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  • Local invasion to right kidney and adrenal, right hemidiaphragm and lung were detected in one patient, right adrenal in another patient and gall bladder, duodenum, gastric wall and pancreas invasion in the other.
  • AHD may rarely extend to the gall bladder, stomach, duodenum, pancreas, right adrenal and kidney, diaphragm, pleura and lung.

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  • (PMID = 17635471.001).
  • [ISSN] 0004-8461
  • [Journal-full-title] Australasian radiology
  • [ISO-abbreviation] Australas Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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15. Zhang YQ, Kritzik M, Sarvetnick N: Identification and expansion of pancreatic stem/progenitor cells. J Cell Mol Med; 2005 Apr-Jun;9(2):331-44
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  • [Title] Identification and expansion of pancreatic stem/progenitor cells.
  • Pancreatic islet transplantation represents an attractive approach for the treatment of diabetes.
  • Adult pancreatic stem cells /progenitor cells have yet to be recognized because limited markers exist for their identification.
  • While the pancreas has the capacity to regenerate under certain circumstances, questions where adult pancreatic stem/progenitor cells are localized, how they are regulated, and even if the pancreas harbors a stem cell population need to be resolved.
  • In this article, we review the recent achievements both in the identification as well as in the expansion of pancreatic stem/progenitor cells.
  • [MeSH-major] Cell Proliferation. Pancreas / cytology. Stem Cells / cytology
  • [MeSH-minor] Animals. Cell Differentiation / physiology. Embryo, Mammalian / cytology. Humans. Insulin / metabolism. Islets of Langerhans / cytology. Islets of Langerhans / metabolism. Models, Biological. Pancreatic Ducts / cytology. Pancreatic Ducts / metabolism. Regeneration / physiology

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  • (PMID = 15963253.001).
  • [ISSN] 1582-1838
  • [Journal-full-title] Journal of cellular and molecular medicine
  • [ISO-abbreviation] J. Cell. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Insulin
  • [Number-of-references] 116
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16. Brandhorst H, Alt A, Huettler S, Raemsch-Guenther N, Kurfuerst M, Bretzel RG, Brandhorst D: The ratio between class II and class I collagenase determines the amount of neutral protease activity required for efficient islet release from the rat pancreas. Transplant Proc; 2005 Jan-Feb;37(1):215-6
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  • [Title] The ratio between class II and class I collagenase determines the amount of neutral protease activity required for efficient islet release from the rat pancreas.
  • Previous investigations clearly showed that the successful release of islets from the pancreas is mediated by both neutral protease (NP) and collagenase, consisting of subclasses I and II showing different capacities to cleave islets from the pancreas.
  • METHODS: Following intraductal pancreas collagenase distension, rat islets were isolated utilizing 20 PZ-U Serva collagenase NB 1 and 1.0 or 0.4 DMC-U NP.
  • [MeSH-major] Collagenases. Islets of Langerhans / cytology. Pancreas / cytology. Peptide Hydrolases / metabolism

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  • (PMID = 15808598.001).
  • [ISSN] 0041-1345
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK 56962-2
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.- / Peptide Hydrolases; EC 3.4.24.- / Collagenases
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17. Rupnik M: The physiology of rodent beta-cells in pancreas slices. Acta Physiol (Oxf); 2009 Jan;195(1):123-38
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  • [Title] The physiology of rodent beta-cells in pancreas slices.
  • Beta-cells in pancreatic islets form complex syncytia.
  • Pancreas slice is a novel method of choice to study the physiology of beta-cells still embedded in their normal cellulo-social context.
  • I present major advantages, list drawbacks and provide an overview on recent advances in our understanding of the physiology of beta-cells using the pancreas slice approach.
  • [MeSH-major] Insulin-Secreting Cells / physiology. Pancreas / physiology

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  • (PMID = 18983446.001).
  • [ISSN] 1748-1716
  • [Journal-full-title] Acta physiologica (Oxford, England)
  • [ISO-abbreviation] Acta Physiol (Oxf)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 200
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18. Plate JM, Plate AE, Shott S, Bograd S, Harris JE: Effect of gemcitabine on immune cells in subjects with adenocarcinoma of the pancreas. Cancer Immunol Immunother; 2005 Sep;54(9):915-25
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  • [Title] Effect of gemcitabine on immune cells in subjects with adenocarcinoma of the pancreas.
  • Effects of gemcitabine (Gemzar) on immune cells were examined in pancreas cancer patients to determine whether it was immunosuppressive, or potentially could be combined with vaccines or other immunotherapy to enhance patient's responses to their tumors.
  • Functional activity was measured by intracellular staining for cytokines before and after T-cell activation, and by interferon gamma production in EliSpot responses to tumor presentation.
  • Immune T-cells were functional in pancreas cancer patients treated with gemcitabine.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Deoxycytidine / analogs & derivatives. Lymphocyte Activation / drug effects. Pancreatic Neoplasms / drug therapy. Pancreatic Neoplasms / immunology. T-Lymphocytes

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  • (PMID = 15782312.001).
  • [ISSN] 0340-7004
  • [Journal-full-title] Cancer immunology, immunotherapy : CII
  • [ISO-abbreviation] Cancer Immunol. Immunother.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; EC 1.17.4.- / Ribonucleotide Reductases
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19. Kristoffersen AB, Viljugrein H, Kongtorp RT, Brun E, Jansen PA: Risk factors for pancreas disease (PD) outbreaks in farmed Atlantic salmon and rainbow trout in Norway during 2003-2007. Prev Vet Med; 2009 Jul 1;90(1-2):127-36
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  • [Title] Risk factors for pancreas disease (PD) outbreaks in farmed Atlantic salmon and rainbow trout in Norway during 2003-2007.
  • Pancreas disease (PD) is an emerging infectious disease in farmed Atlantic salmon (Salmo salar L.) and rainbow trout (Oncorhynchus mykiss Walbaum) caused by salmonid alphavirus (SAV).
  • Records of clinical diagnosis of PD on marine farm sites were used to identify PD case cohorts.
  • In PD case cohorts, PD-outbreaks were defined to start the month the diagnosis was recorded and last until the cohort was terminated.
  • [MeSH-major] Alphavirus Infections / veterinary. Disease Outbreaks / veterinary. Fish Diseases / epidemiology. Oncorhynchus mykiss. Pancreatic Diseases / veterinary. Salmo salar

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  • (PMID = 19419787.001).
  • [ISSN] 1873-1716
  • [Journal-full-title] Preventive veterinary medicine
  • [ISO-abbreviation] Prev. Vet. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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20. Li X, Han D, Kin Ting Kam R, Guo X, Chen M, Yang Y, Zhao H, Chen Y: Developmental expression of sideroflexin family genes in Xenopus embryos. Dev Dyn; 2010 Oct;239(10):2742-7
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  • Whole-mount in situ hybridization analysis reveals that while sideroflexin2 is expressed in the pancreas, sideroflexin1 and 3 display a complex expression in the central nervous system, somites, pronephros, liver, and pancreas.
  • [MeSH-minor] Amino Acid Sequence. Animals. Brain / embryology. Brain / metabolism. Cation Transport Proteins / chemistry. Cation Transport Proteins / classification. Cation Transport Proteins / genetics. Cation Transport Proteins / metabolism. Gene Expression Regulation, Developmental / genetics. Gene Expression Regulation, Developmental / physiology. Liver / embryology. Liver / metabolism. Molecular Sequence Data. Pancreas / embryology. Pancreas / metabolism. Phylogeny. Sequence Homology, Amino Acid. Xenopus

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  • (PMID = 20737508.001).
  • [ISSN] 1097-0177
  • [Journal-full-title] Developmental dynamics : an official publication of the American Association of Anatomists
  • [ISO-abbreviation] Dev. Dyn.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cation Transport Proteins; 0 / Xenopus Proteins
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21. Nakazawa N, Okazaki T, Miyano T: Prenatal detection of isolated gastric duplication cyst. Pediatr Surg Int; 2005 Oct;21(10):831-4
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  • A routine prenatal ultrasonography (US) showed an abdominal cyst with peristalsis and a provisional diagnosis of enteric duplication was made.
  • A healthy male infant was born at 39 weeks gestation and postnatal US identified a cyst, 5x3x2 cm in size, adjacent to the pancreas.
  • At laparotomy, a cyst was found located in the lesser sac, but completely separated from the stomach, and partially adhered to the body of the pancreas and the crura of the diaphragm.

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  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
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22. Vanwoerkom RC, Bentz J, Chen L, Adler DG: EUS diagnosis of a primary pancreatic metastasis of alveolar rhabdomyosarcoma. JOP; 2009;10(6):683-5
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  • [Title] EUS diagnosis of a primary pancreatic metastasis of alveolar rhabdomyosarcoma.
  • Pancreatic metastases from alveolar rhabdomyosarcoma are exceptionally uncommon.
  • Two months later, the patient developed abdominal pain and an MRI documented a 6.4 cm mass in the pancreatic body and tail.
  • EUS guided FNA confirmed the diagnosis of alveolar rhabdomyosarcoma metastatic to the pancreas.
  • CONCLUSION: To our knowledge this is the first reported case of EUS guided FNA diagnosis of alveolar rhabdomyosarcoma metastatic to the pancreas.
  • This is also the only case report of a primary pancreatic metastasis of this type of tumor in a male patient (which occurs less commonly than in females).
  • [MeSH-major] Head and Neck Neoplasms / secondary. Head and Neck Neoplasms / ultrasonography. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / ultrasonography. Rhabdomyosarcoma, Alveolar / ultrasonography


23. Meyerholz DK, Samuel I: Morphologic characterization of early ligation-induced acute pancreatitis in rats. Am J Surg; 2007 Nov;194(5):652-8
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  • BACKGROUND: Bile-pancreatic duct ligation in rats causes acute pancreatic inflammation.
  • We performed serial morphologic evaluation of the exocrine pancreas after duct ligation to facilitate further investigations using the model.
  • METHODS: The pancreas was excised from 74 rats after 0, 1, 3, 5, 24 or 48 hours of duct ligation or sham surgery.

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  • (PMID = 17936429.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / DK062805-05; United States / NIDDK NIH HHS / DK / K08 DK062805; United States / NIDDK NIH HHS / DK / K08 DK062805-05; United States / NIDDK NIH HHS / DK / K08-DK062805
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS32862; NLM/ PMC2128702
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24. Krejci V, Hiltebrand LB, Sigurdsson GH: Effects of epinephrine, norepinephrine, and phenylephrine on microcirculatory blood flow in the gastrointestinal tract in sepsis. Crit Care Med; 2006 May;34(5):1456-63
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  • Microcirculatory flow was measured in gastric, jejunal, and colon mucosa; jejunal muscularis; and pancreas, liver, and kidney using multiple-channel laser Doppler flowmetry.
  • Both agents caused a significant reduction in superior mesenteric artery flow (11 +/- 4%, p < .05, and 26 +/- 6%, p < .01, respectively) and in microcirculatory blood flow in the jejunal mucosa (21 +/- 5%, p < .01, and 23 +/- 3%, p < .01, respectively) and in the pancreas (16 +/- 3%, p < .05, and 8 +/- 3%, not significant, respectively).
  • In fact, norepinephrine and epinephrine appeared to divert blood flow away from the mesenteric circulation and decrease microcirculatory blood flow in the jejunal mucosa and pancreas.
  • [MeSH-minor] Analysis of Variance. Animals. Blood Pressure / drug effects. Cross-Over Studies. Hemodynamics / drug effects. Intestines / blood supply. Liver / blood supply. Microcirculation / drug effects. Pancreas / blood supply. Random Allocation. Swine

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  • [CommentIn] Crit Care Med. 2006 May;34(5):1565-6 [16633263.001]
  • (PMID = 16557162.001).
  • [ISSN] 0090-3493
  • [Journal-full-title] Critical care medicine
  • [ISO-abbreviation] Crit. Care Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vasoconstrictor Agents; 1WS297W6MV / Phenylephrine; X4W3ENH1CV / Norepinephrine; YKH834O4BH / Epinephrine
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25. Doley RP, Yadav TD, Kang M, Dalal A, Jayant M, Sharma R, Wig JD: Traumatic Transection of Pancreas at the Neck: Feasibility of Parenchymal Preserving Strategy. Gastroenterology Res; 2010 Apr;3(2):79-85
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  • [Title] Traumatic Transection of Pancreas at the Neck: Feasibility of Parenchymal Preserving Strategy.
  • BACKGROUND: To assess the feasibility and safety of a pancreas preserving operative technique in the management of isolated complete pancreatic neck transection following blunt abdominal trauma.
  • METHODS: Two patients with isolated blunt fracture of the pancreatic neck underwent pancreas preserving procedure comprising of oversewing of the proximal pancreas and Roux-en-Y pancreatico jejunostomy to the distal remnant.
  • Both had pancreatic transection at neck in the line of superior mesenteric vessels.
  • These patients had pancreas parenchyma preserving surgery - internal drainage of the left remnant in a Roux-en-Y jejunal loop.
  • CONCLUSIONS: Pancreas preserving strategy - suture of head side of pancreas and an internal drainage of left remnant with a Roux-en-Y jejunal loop is feasible and safe and should be considered in selected cases.
  • Substantial amount of normal pancreatic parenchyma is preserved.

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  • (PMID = 27956990.001).
  • [ISSN] 1918-2805
  • [Journal-full-title] Gastroenterology research
  • [ISO-abbreviation] Gastroenterology Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Keywords] NOTNLM ; Abdominal injuries / Organ preservation / Pancreas / Pancreatic anastomosis / Pancreatic injuries
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26. Nishihara E, Miyauchi A, Hirokawa M, Kudo T, Ohye H, Ito M, Kubota S, Fukata S, Amino N, Kuma K: Benign thyroid teratomas manifest painful cystic and solid composite nodules: three case reports and a review of the literature. Endocrine; 2006 Oct;30(2):231-6
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  • [Title] Benign thyroid teratomas manifest painful cystic and solid composite nodules: three case reports and a review of the literature.
  • Benign thyroid teratomas are rare in adolescents and adults.
  • We report on three cases of benign thyroid teratomas that presented as painful tumors in the neck after puberty.
  • The tumor adjacent to the thyroid in each case showed rapid enlargement with predominant cystic lesions within several months.
  • Ultrasonography and computed tomography revealed few findings suggesting the origin of the tumor.
  • Chemical analysis of the aspirate showed levels of pancreatic enzymes higher than those in serum.
  • The patients subsequently underwent resection of the tumor, and microscopic examination revealed various types of tissue including pancreas, adipose, cartilage, muscle, and skin, and the cystic wall was lined by gastric, intestinal, respiratory, and stratified squamous epithelium.
  • Surgical resection was curative, and subsequent histologic examination revealed mature benign teratomas of the thyroid.
  • The main characteristic of our cases presented the painful tumors due to the enlarged cystic formation lined by a variety of different types of epithelium, which agreed with previous cases of benign thyroid teratomas in adolescents and adults.
  • [MeSH-major] Pain / diagnosis. Teratoma / diagnosis. Thyroid Neoplasms / diagnosis. Thyroid Nodule / diagnosis
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Neoplasms / diagnosis

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  • (PMID = 17322585.001).
  • [ISSN] 1355-008X
  • [Journal-full-title] Endocrine
  • [ISO-abbreviation] Endocrine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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27. Barbaros U, Sümer A, Demirel T, Karakullukçu N, Batman B, Içscan Y, Sarıçam G, Serin K, Loh WL, Dinççağ A, Mercan S: Single incision laparoscopic pancreas resection for pancreatic metastasis of renal cell carcinoma. JSLS; 2010 Oct-Dec;14(4):566-70
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  • [Title] Single incision laparoscopic pancreas resection for pancreatic metastasis of renal cell carcinoma.
  • Herein, we report the first transumbilical single incision laparoscopic pancreatectomy case in a patient who had renal cell cancer metastasis on her pancreatic corpus and tail.
  • METHODS: A 59-year-old female who had metastatic lesions on her pancreas underwent laparoscopic subtotal pancreatectomy through a 2-cm umbilical incision.
  • The patient was discharged on the seventh postoperative day with a low-volume (20mL/day) pancreatic fistula that ceased spontaneously.

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  • (PMID = 21605524.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3083051
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28. Huguier M, Barrier A, Gouillat C, Suc B, Jaeck D, Launois B: [Pancreaticoduodenectomy for cancer of the head of the pancreas]. J Chir (Paris); 2008 Jan-Feb;145(1):9-15
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  • [Title] [Pancreaticoduodenectomy for cancer of the head of the pancreas].
  • Preoperative evidence of mesenteric or portal vein involvement does not contraindicate pancreatic resection and survival rates are similar to those of patients with no venous involvement.
  • Three trials and one meta-analysis of pancreatico-gastric anastomosis have failed to demonstrate a decrease in the risk of pancreatic fistula.
  • Two trials suggest that the risk of fistula formation is decreased by implantation of the pancreatic remnant into the jejunum or by trans-jejunal stenting of the pancreatico-jejunal anastomosis with external drainage; but these findings are not supported by a third trial.
  • The use of fibrin glue to occlude the pancreatic duct or seal the cut surface of the pancreas did not decrease the rate of intra-abdominal complications.
  • In conclusion, the pancreaticoduodenal resection described by Whipple may still be considered the gold standard for resection of pancreatic cancer.
  • [MeSH-major] Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods

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  • [CommentIn] J Chir (Paris). 2008 Jan-Feb;145(1):6-8 [18438275.001]
  • (PMID = 18438276.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 76
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29. Mizumoto M, Honjo G, Kobashi Y, Nishimura S, Nakamura Y, Yoshimura T, Awane M, Kato Y, Furuyama H, Asao Y, Maeda H, Takakuwa H, Matsusue S: Preoperative evaluation of malignancy in intraductal papillary mucinous neoplasms of the pancreas, especially in relation to dysplastic epithelial changes. Hepatogastroenterology; 2008 Mar-Apr;55(82-83):704-7
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  • [Title] Preoperative evaluation of malignancy in intraductal papillary mucinous neoplasms of the pancreas, especially in relation to dysplastic epithelial changes.
  • BACKGROUND/AIMS: Intraductal papillary mucinous neoplasms have a better prognosis than ductal adenocarcinomas of the pancreas.
  • METHODOLOGY: Forty-three intraductal papillary mucinous neoplasms were divided into 3 duct ectatic types using preoperative images (the main duct type, the branch duct type, and the mixed type), and into 2 groups using resected specimens (the malignant group including severe dysplasia based on the WHO classification and the benign group).
  • The diameters of the tumor, main pancreatic duct and mural nodule were measured on the images.
  • For the branch duct and mixed types, the diameters of the tumor and detectable mural nodules were larger in the malignant group than in the benign group.
  • A tumor diameter larger than 3.5cm and a mural nodule diameter larger than 6mm were risk factors for malignancy (p < 0.05).
  • CONCLUSIONS: The main duct type, a tumor larger than 3.5cm of the branch duct or mixed type, and a mural nodule larger than 6mm were all indicators of malignancy risk.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma, Papillary / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 18613438.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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31. Zhao HL, Sui Y, Guan J, Lai FM, Gu XM, He L, Zhu X, Rowlands DK, Xu G, Tong PC, Chan JC: Topographical associations between islet endocrine cells and duct epithelial cells in the adult human pancreas. Clin Endocrinol (Oxf); 2008 Sep;69(3):400-6
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  • [Title] Topographical associations between islet endocrine cells and duct epithelial cells in the adult human pancreas.
  • OBJECTIVES: The pancreatic ducts, endocrine islets and exocrine acini are three functionally related components.
  • The objective of this study is to investigate the topographical associations between the islet endocrine cells and duct epithelial cells in the adult human pancreas.
  • MATERIALS AND METHODS: Panels of immunomarkers for the exocrine acinar cells (amylase), duct cells [cytokeratin 19 (CK19)], endocrine cells (chromogranin A, neurone specific enolase, synaptophysin) and islet hormones (glucagon, insulin, somatostatin, pancreatic polypeptide) were applied to sequential pancreatic tissue sections obtained from autopsy specimens of 10-nondiabetic human adults.
  • CONCLUSIONS: Topographical associations between islet endocrine cells and pancreatic duct cells are frequent in adult human pancreas.
  • The islet-duct association suggests possible functional interactions between the two interrelated pancreatic compartments.
  • [MeSH-major] Epithelial Cells / cytology. Islets of Langerhans / cytology. Pancreatic Ducts / cytology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers / metabolism. Endocrine Cells / cytology. Endocrine Cells / immunology. Endocrine Cells / metabolism. Female. Glucagon / metabolism. Humans. Insulin / metabolism. Male. Middle Aged. Pancreas / cytology. Pancreas / immunology. Pancreas / metabolism

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  • (PMID = 18221396.001).
  • [ISSN] 1365-2265
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Insulin; 9007-92-5 / Glucagon
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32. Sakuramoto S, Kikuchi S, Futawatari N, Katada N, Moriya H, Hirai K, Yamashita K, Watanabe M: Laparoscopy-assisted pancreas- and spleen-preserving total gastrectomy for gastric cancer as compared with open total gastrectomy. Surg Endosc; 2009 Nov;23(11):2416-23
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  • [Title] Laparoscopy-assisted pancreas- and spleen-preserving total gastrectomy for gastric cancer as compared with open total gastrectomy.
  • METHODS: From July 2004 to July 2007, we performed pancreas- and spleen-preserving total gastrectomy with D1 + beta or D2 lymph-node dissection and Roux-en-Y reconstruction in 74 patients with cancer located in the upper or middle third of the stomach.
  • However, major complications such as anastomotic leakage, abdominal abscess, and pancreatic leakage occurred in six patients (13.6%) in the OTG group, but in none of the patients in the LATG group.
  • [MeSH-major] Gastrectomy / methods. Gastroscopy / methods. Lymph Nodes / pathology. Neoplasm Recurrence, Local / epidemiology. Stomach Neoplasms / surgery
  • [MeSH-minor] Anastomosis, Surgical. Chi-Square Distribution. Cohort Studies. Female. Follow-Up Studies. Humans. Laparotomy / adverse effects. Laparotomy / methods. Lymph Node Excision / methods. Male. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Staging. Pancreas. Postoperative Complications / mortality. Postoperative Complications / physiopathology. Retrospective Studies. Risk Assessment. Spleen. Survival Analysis. Treatment Outcome

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  • [CommentIn] Surg Endosc. 2010 Sep;24(9):2355-7 [20177935.001]
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  • (PMID = 19266232.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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33. Akimoto Y, Hart GW, Wells L, Vosseller K, Yamamoto K, Munetomo E, Ohara-Imaizumi M, Nishiwaki C, Nagamatsu S, Hirano H, Kawakami H: Elevation of the post-translational modification of proteins by O-linked N-acetylglucosamine leads to deterioration of the glucose-stimulated insulin secretion in the pancreas of diabetic Goto-Kakizaki rats. Glycobiology; 2007 Feb;17(2):127-40
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  • [Title] Elevation of the post-translational modification of proteins by O-linked N-acetylglucosamine leads to deterioration of the glucose-stimulated insulin secretion in the pancreas of diabetic Goto-Kakizaki rats.
  • By immunoblot and immunohistochemical analyses, the expression of O-GlcNAc transferase protein and O-GlcNAc-modified proteins in whole pancreas and islets of Langerhans of 15-week-old diabetic GK rats and nondiabetic Wistar rats was examined.
  • The expression of O-GlcNAc transferase at the protein level and O-GlcNAc transferase activity were increased significantly in the diabetic pancreas and islets.
  • The diabetic pancreas and islets also showed an increase in total cellular O-GlcNAc-modified proteins.
  • These results indicate that elevation of the O-GlcNAcylation of proteins leads to deterioration of insulin secretion in the pancreas of diabetic GK rats, further providing evidence for the role of O-GlcNAc in the insulin secretion.
  • [MeSH-minor] Animals. Glucose / pharmacology. Islets of Langerhans / chemistry. Islets of Langerhans / drug effects. Islets of Langerhans / secretion. N-Acetylglucosaminyltransferases / analysis. N-Acetylglucosaminyltransferases / antagonists & inhibitors. N-Acetylglucosaminyltransferases / metabolism. Pancreas / chemistry. Pancreas / drug effects. Pancreas / secretion. RNA Interference. Rats. Rats, Wistar

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  • (PMID = 17095531.001).
  • [ISSN] 0959-6658
  • [Journal-full-title] Glycobiology
  • [ISO-abbreviation] Glycobiology
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK61671
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / Insulin; 0 / Trans-Activators; 0 / pancreatic and duodenal homeobox 1 protein; EC 2.4.1.- / N-Acetylglucosaminyltransferases; EC 2.4.1.- / UDP-N-acetylglucosamine-peptide beta-N-acetylglucosaminyltransferase; IY9XDZ35W2 / Glucose; V956696549 / Acetylglucosamine
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34. Pedrosa I, Boparai D: Imaging considerations in intraductal papillary mucinous neoplasms of the pancreas. World J Gastrointest Surg; 2010 Oct 27;2(10):324-30
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  • [Title] Imaging considerations in intraductal papillary mucinous neoplasms of the pancreas.
  • With the widespread use of cross-sectional imaging, particularly computed tomography (CT) and magnetic resonance imaging (MRI), and the continuous improvement in the image quality of these techniques, the diagnosis of incidental pancreatic cysts has increased dramatically in the last decades.
  • While the vast majority of these cysts are not clinically relevant, a small percentage of them will evolve into an invasive malignant tumor making their management challenging.
  • Mucinous cystic neoplasms and intraductal papillary mucinous neoplasms (IPMN) are the most common pancreatic cystic lesions with malignant potential.
  • MRI is superior to CT in demonstrating the communication of a branch duct IPMN with the main pancreatic duct (MPD).
  • Most branch duct lesions are benign whereas tumors involving the MPD are frequently associated with malignancy.
  • The presence of solid nodules, thick enhancing walls and/or septae, a wide (> 1 cm) connection of a side-branch lesion with the MPD and the size of the tumor > 3 cm are indicative of malignancy in a branch and mixed type IPMN.
  • A main pancreatic duct > 6 mm, a mural nodule > 3 mm and an abnormal attenuating area in the adjacent pancreatic parenchyma on CT correlates with malignant disease in main duct and mixed type IPMN.
  • We also discuss follow-up strategies for patients with surgically resected IPMN and patients with incidental pancreatic cysts.

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  • (PMID = 21160838.001).
  • [ISSN] 1948-9366
  • [Journal-full-title] World journal of gastrointestinal surgery
  • [ISO-abbreviation] World J Gastrointest Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2999202
  • [Keywords] NOTNLM ; Computed tomography / Intraductal papillary mucinous neoplasms / Magnetic resonance imaging / Pancreatic neoplasms
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35. Stringer MD, Davison SM, McClean P, Rajwal S, Puntis JW, Sheridan M, Ramsden W, Woodley H: Multidisciplinary management of surgical disorders of the pancreas in childhood. J Pediatr Gastroenterol Nutr; 2005 Mar;40(3):363-7
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  • [Title] Multidisciplinary management of surgical disorders of the pancreas in childhood.
  • OBJECTIVES: To describe the frequency and range of pancreatic disorders in children requiring surgical intervention and to highlight the importance of multidisciplinary management.
  • METHODS: An audit of all children under 17 years of age referred with surgical disorders of the pancreas or pancreatitis to a regional pediatric gastroenterology unit in the United Kingdom during a 10-year period.
  • RESULTS: Surgical intervention was required for the following pancreatic disorders: persistent hyperinsulinemic hypoglycemia of infancy (n = 4), pancreatic tumors (n = 5), pancreaticobiliary malunion (n = 12), pancreatic trauma (n = 6) and pancreatitis (n = 10).
  • The indications for surgery in acute pancreatitis were a persistent pseudocyst (n = 1) and treatment of an underlying cause of pancreatitis (n = 4); in chronic pancreatitis, surgery was used to treat symptomatic pancreatic duct strictures (n = 4).
  • All 33 children with acute pancreatitis, including four with pancreatic necrosis, survived.
  • CONCLUSIONS: Surgery for pancreatic disorders in children is rarely required but may be necessary a) for definitive management of primary pancreatic pathology, b) to treat sequelae of acute or chronic pancreatitis and c) to treat an underlying cause of pancreatitis.
  • [MeSH-major] Pancreatic Diseases / surgery. Pancreatitis / surgery
  • [MeSH-minor] Acute Disease. Adolescent. Child. Child, Preschool. Congenital Hyperinsulinism / pathology. Congenital Hyperinsulinism / surgery. Disease-Free Survival. Female. Great Britain. Humans. Infant. Male. Pancreas / injuries. Pancreas / pathology. Pancreas / surgery. Pancreatectomy. Pancreatic Cyst / pathology. Pancreatic Cyst / surgery. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery. Retrospective Studies. Treatment Outcome

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  • (PMID = 15735494.001).
  • [ISSN] 0277-2116
  • [Journal-full-title] Journal of pediatric gastroenterology and nutrition
  • [ISO-abbreviation] J. Pediatr. Gastroenterol. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Qian ZY, Miao Y, Dai CC, Xu ZK, Liu XL: [Combined multiple organ resection in 16 patients with adenocarcinoma of the body or tail of the pancreas]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2005 Oct;27(5):572-4
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  • [Title] [Combined multiple organ resection in 16 patients with adenocarcinoma of the body or tail of the pancreas].
  • OBJECTIVE: To investigate the feasibility and therapeutic results of multiple organ resection in patients with tumor of the body and tail of pancreas.
  • METHODS: The clinical and pathological data were analysed in 16 consecutive patients with neoplasm of the body and tail of pancreas from 1999 to 2004 retrospectively.
  • RESULTS: Multiple organ resection was performed in 6 cases of primary pancreatic adenocarcinoma of the body and tail (3 cases of pancreatic cancer, 2 cases of malignant glucagonoma, and 1 case of well-differentiated pancreatic stromal sarcoma) and 10 cases of extrapancreatic malignancy (4 cases of gastric cancer, 2 cases of gastric leiomyosarcoma, 1 case of duodenal cancer, and 3 cases of colon cancer of hepatic flexure).
  • Patients with primary pancreatic cancer or pancreatic stromal sarcoma died within 1 year.
  • [MeSH-major] Adenocarcinoma / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery

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  • (PMID = 16274034.001).
  • [ISSN] 1000-503X
  • [Journal-full-title] Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
  • [ISO-abbreviation] Zhongguo Yi Xue Ke Xue Yuan Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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37. Borelli MI, Del Zotto H, Flores LE, García ME, Boschero AC, Gagliardino JJ: Transcription, expression and tissue binding in vivo of INGAP and INGAP-related peptide in normal hamsters. Regul Pept; 2007 May 3;140(3):192-7
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  • We studied islet neogenesis-associated protein (INGAP) transcription and its immunocytochemical presence in and binding in vivo of (125)I-tyrosylated INGAP pentadecapeptide ((125)I-T-INGAP-PP) to different normal male hamster tissues. (125)I-T-INGAP-PP was injected intraperitoneally with or without unlabeled T-INGAP-PP (0-1 mg/100 g bw), drawing blood samples at different times after injection; radioactivity was measured in serum, brain, skeletal muscle, dorsal root ganglia, liver, kidney, small intestine and pancreas samples, expressing results as organ:serum ratio.
  • INGAP transcription (RT-PCR) and immunopositive cells were investigated in liver, kidney, brain, small intestine and pancreas.
  • Only liver, pancreas and small intestine specifically bound (125)I-T-INGAP-PP.
  • The pancreas tissue dose-response curve showed a 50% displacement at 3.9x10(4) ng/100 g bw, suggesting a low binding affinity of its receptor.
  • INGAP-mRNA was only identified in pancreatic islets and exocrine tissue.
  • Our results suggest that INGAP transcription/expression is probably restricted to pancreas cells exerting its effect in a paracrine fashion.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Biomarkers, Tumor / metabolism. Cytokines / metabolism. Cytokines / pharmacokinetics. Lectins, C-Type / metabolism. Pancreas / metabolism. Peptide Fragments / metabolism. Peptide Fragments / pharmacokinetics

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  • (PMID = 17320200.001).
  • [ISSN] 0167-0115
  • [Journal-full-title] Regulatory peptides
  • [ISO-abbreviation] Regul. Pept.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Cytokines; 0 / INGAP peptide; 0 / Lectins, C-Type; 0 / Peptide Fragments; 0 / RNA, Messenger; 0 / pancreatitis-associated protein
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38. Shen L, Liu X, Hou W, Yang G, Wu Y, Zhang R, Li X, Che H, Lu Z, Zhang Y, Liu X, Yao L: NDRG2 is highly expressed in pancreatic beta cells and involved in protection against lipotoxicity. Cell Mol Life Sci; 2010 Apr;67(8):1371-81
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  • [Title] NDRG2 is highly expressed in pancreatic beta cells and involved in protection against lipotoxicity.
  • The N-myc downstream-regulated gene 2 (NDRG2) is involved in cell differentiation and apoptosis, but its function in the pancreas remains to be established.
  • Herein we examine the expression and function of NDRG2 in the endocrine pancreas.
  • NDRG2 immunoreactivity was localized mainly in the cytoplasm of pancreatic beta cells.
  • Collectively, these data indicate that NDRG2 acts as a key molecule in pancreatic beta cells and is involved in the Akt-mediated protection of beta cells against lipotoxicity.
  • [MeSH-major] Fatty Acids, Nonesterified / pharmacology. Insulin-Secreting Cells / metabolism. Proteins / metabolism. Tumor Suppressor Proteins / metabolism

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  • (PMID = 20127388.001).
  • [ISSN] 1420-9071
  • [Journal-full-title] Cellular and molecular life sciences : CMLS
  • [ISO-abbreviation] Cell. Mol. Life Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Fatty Acids, Nonesterified; 0 / NDRG2 protein, human; 0 / Ndr2 protein, mouse; 0 / Proteins; 0 / RNA, Messenger; 0 / RNA, Small Interfering; 0 / Tumor Suppressor Proteins
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39. Golson ML, Loomes KM, Oakey R, Kaestner KH: Ductal malformation and pancreatitis in mice caused by conditional Jag1 deletion. Gastroenterology; 2009 May;136(5):1761-71.e1
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  • BACKGROUND & AIMS: Alagille syndrome is an autosomal dominant disorder caused by mutations in Notch signaling pathway genes, usually JAGGED1.
  • Up to 40% of Alagille syndrome patients also display exocrine pancreatic insufficiency, the pathobiology of which is unknown.
  • METHODS: We conditionally deleted both alleles of Jagged1 in the murine pancreas using Cre-loxP technology and analyzed histologic and morphologic features in postnatal and adult pancreas such as duct structure, acinar mass, and T-lymphocyte infiltration, as well as markers of pancreatic function, including fecal fat.
  • RESULTS: Jagged1-deficient mice displayed malformed pancreatic ducts with resulting acinar cell death, fatty infiltration of the parenchyma, fibrosis, pancreatitis, and pancreatic insufficiency.
  • CONCLUSIONS: Pancreatic ductal malformation and acinar cell loss may be responsible for pancreatic insufficiency in Jagged1-deficient mice and, by corollary, in Alagille syndrome patients.
  • [MeSH-major] Calcium-Binding Proteins / genetics. Gene Deletion. Intercellular Signaling Peptides and Proteins / genetics. Membrane Proteins / genetics. Pancreatic Ducts / abnormalities. Pancreatitis / genetics
  • [MeSH-minor] Adipocytes / pathology. Alagille Syndrome / genetics. Animals. Glucose / metabolism. Homeostasis. Mice. Mice, Knockout. Mice, Mutant Strains. Pancreas / metabolism. Pancreas / pathology

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  • (PMID = 19208348.001).
  • [ISSN] 1528-0012
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK055342; United States / NIDDK NIH HHS / DK / DK071; United States / NIDDK NIH HHS / DK / P30DK19525; United States / NIDDK NIH HHS / DK / P30DK50306
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium-Binding Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Membrane Proteins; 134324-36-0 / Serrate proteins; IY9XDZ35W2 / Glucose
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40. Carrara S, Arcidiacono PG, Albarello L, Addis A, Enderle MD, Boemo C, Campagnol M, Ambrosi A, Doglioni C, Testoni PA: Endoscopic ultrasound-guided application of a new hybrid cryotherm probe in porcine pancreas: a preliminary study. Endoscopy; 2008 Apr;40(4):321-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic ultrasound-guided application of a new hybrid cryotherm probe in porcine pancreas: a preliminary study.
  • BACKGROUND AND STUDY AIMS: Open, laparoscopic, or percutaneous radiofrequency (RF) ablation of the pancreas is still dangerous, whereas endoscopic ultrasound (EUS)-guided ablation might reduce risk because it is less invasive and provides real-time monitoring.
  • CONCLUSIONS: Selective transluminal RF ablation of the pancreas under EUS control in a living pig model is feasible.
  • [MeSH-major] Catheter Ablation / instrumentation. Cryosurgery / instrumentation. Pancreas / surgery. Pancreas / ultrasonography

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  • (PMID = 18389449.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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41. Vadalà S, Calderera G, Cinardi N, Manusia M, Li Volti G, Giannone G: Serous cystadenocarcinoma of the pancreas with portal thrombosis. Clin Ter; 2010;161(2):149-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serous cystadenocarcinoma of the pancreas with portal thrombosis.
  • Serous cystadenocarcinoma of the pancreas is a rare entity.
  • We report on a primary tumor of the pancreas in a 74-year-old male.
  • Computerized tomography showed an abdominal mass within pancreatic head, portal vein infiltration and absence of metastatic lesions.
  • To the knowledge of the authors, serous cystic neoplasms of the pancreas have been uniformly benign in biologic behaviour.
  • However, serous cystadenocarcinoma of the pancreas has been reported as a new entity.
  • [MeSH-major] Cystadenocarcinoma, Serous / complications. Pancreatic Neoplasms / complications. Portal Vein. Venous Thrombosis / etiology


42. Hubert T, Arnalsteen L, Jany T, Prieur E, Triponez F, Nunes B, Vantyghem MC, Gmyr V, Kerr-Conte J, Proye C, Pattou F: [Technique of pancreatic procurement for pancreatic islet isolation]. Ann Chir; 2005 Jul-Aug;130(6-7):384-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Technique of pancreatic procurement for pancreatic islet isolation].
  • [Transliterated title] Technique du prélèvement pancréatique pour l'isolement des îlots de Langerhans.
  • AIM OF THE STUDY: The allograft of pancreatic islets represents a potential alternative to insulin therapy in patients suffering from the most severe forms of Type 1 diabetes.
  • Here we report our experience of pancreatic procurement for isolation and islet allograft.
  • MATERIALS AND METHODS: Pancreata were procured in brain-dead donors.
  • RESULTS: Twenty-nine pancreata were procured and 14 preparations were grafted to 7 patients.
  • CONCLUSION: These preliminary clinical results confirmed that the isolation technique of human islets and the technique of pancreas procurement are mastered by our team.
  • [MeSH-major] Islets of Langerhans Transplantation / methods. Pancreas Transplantation / methods. Tissue and Organ Procurement / methods

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  • (PMID = 16023459.001).
  • [ISSN] 0003-3944
  • [Journal-full-title] Annales de chirurgie
  • [ISO-abbreviation] Ann Chir
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
  • [Number-of-references] 16
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43. Miro JM, Ricart MJ, Trullas JC, Cofan F, Cervera C, Brunet M, Tuset M, Manzardo C, Oppenheimer F, Moreno A: Simultaneous pancreas-kidney transplantation in HIV-infected patients: a case report and literature review. Transplant Proc; 2010 Nov;42(9):3887-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Simultaneous pancreas-kidney transplantation in HIV-infected patients: a case report and literature review.
  • In contrast with liver and kidney transplantation, only three simultaneous pancreas-kidney transplants (SPKT) have been reported among HIV-infected patients.
  • The pancreas graft failed at 2 weeks and the patient died at 9 months because of a Pseudomonas aeruginosa infection.
  • The three recipients reported in the literature lived, despite the failure of both the pancreas and kidney grafts in one subject.
  • [MeSH-major] Anti-Retroviral Agents / therapeutic use. HIV Infections / drug therapy. Immunosuppressive Agents / therapeutic use. Kidney Transplantation. Pancreas Transplantation


44. Kamisawa T, Tu Y, Egawa N, Tsuruta K, Okamoto A: Clinical implications of incomplete pancreas divisum. JOP; 2006;7(6):625-30
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  • [Title] Clinical implications of incomplete pancreas divisum.
  • CONTEXT: Incomplete pancreas divisum is a pancreatic anomaly that results in an inadequate communication between the ventral and dorsal pancreatic ducts.
  • Although the relationship between complete pancreas divisum and pancreatitis has been contentious, clinical implications of incomplete pancreas divisum have not been noted.
  • OBJECTIVE: This study was done to investigate the clinical significance of incomplete pancreas divisum.
  • PATIENTS AND METHODS: We studied the anatomy of the pancreatic duct system in 3,220 cases using endoscopic retrograde pancreatography; 44 cases had complete pancreas divisum, and 41 had incomplete pancreas divisum.
  • MAIN OUTCOME MEASURE: The prevalence of chronic and acute pancreatitis associated with complete or incomplete pancreas divisum was compared with that of cases with neither complete nor incomplete pancreas divisum (controls).
  • RESULTS: All of the patients with complete or incomplete pancreas divisum who abused alcohol had chronic or acute pancreatitis.
  • The prevalence of chronic pancreatitis in patients with complete or incomplete pancreas divisum was significantly higher than in controls (P<0.001 and P=0.001, respectively), but acute pancreatitis occurred more frequently only in patients with complete pancreas divisum (P=0.010).
  • When we considered pancreatic-type pain as a pancreatitis-like disease, complete and incomplete pancreas divisum were suspected as the cause of pancreatitis-like disease in 39% (15/38: chronic dorsal pancreatitis, n=5; acute pancreatitis, n=7; pancreatic-type pain, n=3) and 30% (10/33: chronic dorsal pancreatitis, n=2; acute relapsing pancreatitis, n=1; pancreatic-type pain, n=7) of patients who did not abuse alcohol, respectively.
  • CONCLUSIONS: Although the precise pathophysiology may differ, patients with complete pancreas divisum and patients with incomplete pancreas divisum may have similar presentations and a similar prevalence.
  • The clinical implications of incomplete pancreas divisum may be similar to those of complete pancreas divisum.
  • [MeSH-major] Pancreas / abnormalities
  • [MeSH-minor] Acute Disease / epidemiology. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Pancreatic Ductal / epidemiology. Cholangiopancreatography, Endoscopic Retrograde. Female. Humans. Male. Middle Aged. Pancreatic Neoplasms / epidemiology. Pancreatitis / epidemiology. Pancreatitis, Alcoholic / epidemiology. Pancreatitis, Chronic / epidemiology. Prevalence. Retrospective Studies

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  • (PMID = 17095842.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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45. Tracey JY, Moossa AR: Unusual tumours of the pancreas. Surgeon; 2009 Aug;7(4):216-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual tumours of the pancreas.
  • All pancreatic masses are not necessarily the dismal pancreatic ductal adenocaricoma (PDA) and do not necessarily deserve a gloomy prognosis or a nihilistic attitude.
  • We review a rarer group of pancreatic lesions and discuss their pathogenesis, diagnosis and treatment.
  • A tumour specific selective surgical approach is recommended.
  • The outcome is dependent on the tumour histology and the biological behaviour.
  • The degree of malignancy is variable and ranges across benign, borderline and malignant entities.
  • BACKGROUND: The advent of more sophisticated and ever widely employed imaging modalities has identified the presence of many unsuspected unusual masses in the pancreas.
  • These lesions display natural histories and biological behaviours distinct from adenocarcinoma of the pancreas (PDA).
  • Though the list is long they include neuroendocrine tumours, cystic tumours, primary pancreatic lymphoma, solid pseudopapillary tumours, connective tissue tumours, metastatic lesions to the pancreas and many others.
  • [MeSH-major] Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery

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  • (PMID = 19736888.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Scotland
  • [Number-of-references] 50
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46. Gaudez F, Meria P, Desgrandchamps F, Roussin F, Roussin O, Teillac P: [Total pancreas sampling and transplantation]. Ann Urol (Paris); 2006 Feb;40(1):39-49
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Total pancreas sampling and transplantation].
  • [Transliterated title] Prélévement et transplantation de pancréas total.
  • Pancreas removal and transplantation consists in three main steps: sampling, preparation of the transplant with reconstruction of vessels and finally transplantation.
  • Sampling requires good anatomical knowledge and perfect synchronization between hepatic surgeons so as to ensure adequate dissection of liver and pancreas vessels: portal vein, splenic, upper mesenteric and hepatic arteries.
  • The preparation of the pancreatic graft consists in reconstructing the unique arterial axis using an iliac arterial fork sutured with upper mesenteric and splenic arteries.
  • It must be done carefully to avoid any risk of pancreas fistula.
  • [MeSH-major] Pancreas / surgery. Pancreas Transplantation / methods. Tissue and Organ Harvesting / methods

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  • (PMID = 16552905.001).
  • [ISSN] 0003-4401
  • [Journal-full-title] Annales d'urologie
  • [ISO-abbreviation] Ann Urol (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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47. Chiang CP, Wu CW, Lee SP, Chung CC, Wang CW, Lee SL, Nieh S, Yin SJ: Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human pancreas: implications for pathogenesis of alcohol-induced pancreatic injury. Alcohol Clin Exp Res; 2009 Jun;33(6):1059-68
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human pancreas: implications for pathogenesis of alcohol-induced pancreatic injury.
  • The metabolic effect and metabolites contribute to pathogenesis of pancreatic injury.
  • The goal of this study was to determine the functional expressions and cellular localization of ADH and ALDH families in human pancreas.
  • METHODS: Fifty five surgical specimens of normal pancreas as well as 15 samples each for chronic pancreatitis and pancreatic cancer from archival formalin-fixed paraffin-embedded tissue specimens were investigated.
  • The expression of ADH1C appeared to be increased in the activated pancreatic stellate cells in chronic pancreatitis and pancreatic cancer.
  • CONCLUSIONS: Alcohol dehydrogenase and ALDH family members are differentially expressed in the various cell types of pancreas.
  • ADH1C may play an important role in modulation of activation of pancreatic stellate cells.
  • [MeSH-major] Alcohol Dehydrogenase / metabolism. Aldehyde Dehydrogenase / metabolism. Central Nervous System Depressants / metabolism. Ethanol / metabolism. Pancreas / enzymology. Pancreatic Neoplasms / enzymology. Pancreatitis / enzymology

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  • (PMID = 19382905.001).
  • [ISSN] 1530-0277
  • [Journal-full-title] Alcoholism, clinical and experimental research
  • [ISO-abbreviation] Alcohol. Clin. Exp. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Central Nervous System Depressants; 0 / Isoenzymes; 3K9958V90M / Ethanol; EC 1.1.1.1 / ADH1B protein, human; EC 1.1.1.1 / ADH1C protein, human; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 1.2.1.3 / ALDH2 protein, human; EC 1.2.1.3 / Aldehyde Dehydrogenase
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48. Barreda Bolaños F, Landeo Aliaga I, Pando Huarcaya S, Bayro Peñaloza F: [Pancreatic adenocarcinoma in young patient diagnosed by endoscopic ultrasonography]. Rev Gastroenterol Peru; 2008 Apr-Jun;28(2):162-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pancreatic adenocarcinoma in young patient diagnosed by endoscopic ultrasonography].
  • [Transliterated title] Adenocarcinoma de páncreas en paciente joven diagnosticado por ultrasonografía endoscópica.
  • The Pancreatic adenocarcinoma appears generally in patients with more than 60 years old.
  • The tomografic image showed a mass located in the head of the pancreas with hepatic and ganglionar metastases.
  • It was evaluated by means of endoscopic ultrasonography (USE) and performed a directed fine needle puncture aspiration (PAAF), that obtained a bad differentiated adenocarcinoma from the pancreas.
  • We present the case by the unusual occurrence in the related age group and by the importance of the puncture guided by endoscopic ultrasonography in the diagnosis and handling of this pathology [corrected]
  • [MeSH-major] Adenocarcinoma / ultrasonography. Endosonography. Pancreatic Neoplasms / ultrasonography

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  • [ErratumIn] Rev Gastroenterol Peru. 2008 Jul-Sep;28(3):293
  • (PMID = 18641779.001).
  • [ISSN] 1022-5129
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Peru
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49. Yoshizumi T, Shimada M, Soejima Y, Terashi T, Taketomi A, Maehara Y: Successful pylorus-preserving pancreaticoduodenectomy for a patient with carcinoma of the papilla Vater two years after living donor liver transplantation. Hepatogastroenterology; 2007 Apr-May;54(75):941-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • For this reason, recurrent primary disease and/or de novo malignancy regarded as chronic immunosuppressant have been paid a great deal of attention.
  • Even pancreas cancer after liver transplantation is extremely rare and has never been successfully treated.
  • Furthermore, cancer of the papilla Vater, which is less frequent than pancreas cancer after liver transplantation has not been reported as yet.

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  • (PMID = 17591098.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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50. Kampf C, Jansson L: Mast cells accumulate in the renal capsule adjacent to transplanted pancreatic islets in rats. Cell Biol Int; 2006 Dec;30(12):1054-6
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  • [Title] Mast cells accumulate in the renal capsule adjacent to transplanted pancreatic islets in rats.
  • Mast cells are important mediators of normal angiogenesis, and participate in normal would healing, i.e. processes involved in pancreatic islet engraftment.
  • The animals were killed 1 month later, and the kidneys and endogenous pancreas were removed, fixed and embedded in paraffin.
  • Mast cells interspersed between graft endocrine cells were as rare as in the endogenous pancreas.

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  • (PMID = 17074512.001).
  • [ISSN] 1065-6995
  • [Journal-full-title] Cell biology international
  • [ISO-abbreviation] Cell Biol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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51. Demirjian AN, Vollmer CM, McDermott DF, Mullen JT, Atkins MB, Callery MP: Refining indications for contemporary surgical treatment of renal cell carcinoma metastatic to the pancreas. HPB (Oxford); 2009 Mar;11(2):150-3
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  • [Title] Refining indications for contemporary surgical treatment of renal cell carcinoma metastatic to the pancreas.
  • BACKGROUND: The pancreas is a rare location for metastatic disease, with only 2-11% of all pancreatic tumours being of non-primary origin.
  • It is also uncommon for renal cell carcinoma (RCC) to metastasize to the pancreas (1-3% of cases) and, when it does, it typically occurs substantially after index nephrectomy.
  • It is not known whether all pancreatic metastases need be resected because today's chemo- and biological therapies are increasingly effective in controlling advanced disease.
  • CONCLUSIONS: Renal cell carcinoma metastases to the pancreas typically occur long after index nephrectomy.

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  • [Cites] Jpn J Clin Oncol. 2004 Nov;34(11):696-9 [15613561.001]
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  • (PMID = 19590640.001).
  • [ISSN] 1365-182X
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2697876
  • [Keywords] NOTNLM ; operative palliatively / pancreatic metastases / renal cell carcinoma
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52. Harries LW, Ellard S, Stride A, Morgan NG, Hattersley AT: Isomers of the TCF1 gene encoding hepatocyte nuclear factor-1 alpha show differential expression in the pancreas and define the relationship between mutation position and clinical phenotype in monogenic diabetes. Hum Mol Genet; 2006 Jul 15;15(14):2216-24
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  • [Title] Isomers of the TCF1 gene encoding hepatocyte nuclear factor-1 alpha show differential expression in the pancreas and define the relationship between mutation position and clinical phenotype in monogenic diabetes.
  • Heterozygous mutations in the transcription factor hepatocyte nuclear factor-1 alpha (HNF1A or TCF1 gene) result in early-onset diabetes as a result of pancreatic beta-cell dysfunction.
  • Real-time PCR demonstrated variation in tissue expression of HNF1A isomers: HNF1A(A), with the lowest transactivation activity compared with the truncated isoforms HNF1A(B) and HNF1A(C), is the major isomer in liver (54%) and kidney (67%) but not in adult pancreas (24%) and islets (26%).
  • However, in fetal pancreas HNF1A(A) is the major transcript (84%), which supports developmental regulation of isomer expression.
  • [MeSH-major] Diabetes Mellitus, Type 2 / genetics. Diabetes Mellitus, Type 2 / metabolism. Hepatocyte Nuclear Factor 1-alpha / genetics. Mutation. Pancreas / metabolism

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  • (PMID = 16760222.001).
  • [ISSN] 0964-6906
  • [Journal-full-title] Human molecular genetics
  • [ISO-abbreviation] Hum. Mol. Genet.
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / HNF1A protein, human; 0 / Hepatocyte Nuclear Factor 1-alpha; 0 / Protein Isoforms; 0 / RNA, Messenger
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53. Itoh M, Takizawa Y, Hanai S, Okazaki S, Miyata R, Inoue T, Akashi T, Hayashi M, Goto Y: Partial loss of pancreas endocrine and exocrine cells of human ARX-null mutation: consideration of pancreas differentiation. Differentiation; 2010 Sep-Oct;80(2-3):118-22
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  • [Title] Partial loss of pancreas endocrine and exocrine cells of human ARX-null mutation: consideration of pancreas differentiation.
  • Since ARX expresses in the islets of Langerhans during the embryonic stage, these visceral phenotypes may be related to a loss of ARX function, which develops endocrine cells in the pancreas.
  • We investigated the abnormal pancreatic development of XLAG patients with ARX-null mutation.
  • We performed immunohistochemistry of XLAG pancreases, using the antibodies against glucagon, insulin, somatostatin, pancreatic polypeptide, ghrelin, Brn4, Nkx2.2, Mash1, amylase and pancreatic lipase.
  • As the results, the glucagon- and pancreatic polypeptide-producing cells were found to be completely deficient in the islets of Langerhans.
  • These pathological findings indicate that ARX contributes not only to endocrine development, but also to exocrine development of the human pancreas, and its deficiency may lead to the severe phenotypes of XLAG patients.

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  • [Copyright] Copyright © 2010 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20538404.001).
  • [ISSN] 1432-0436
  • [Journal-full-title] Differentiation; research in biological diversity
  • [ISO-abbreviation] Differentiation
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / ARX protein, human; 0 / Homeodomain Proteins; 0 / Transcription Factors
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54. Porrett PM, Yeh H, Frank A, Deng S, Kim JI, Barker CF, Markmann JF: Availability of suitable islet donors in the United States. Transplantation; 2007 Jul 27;84(2):280-2
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  • RESULTS: Of 27,552 potential donors during this period, 6,140 donor pancreata were used for whole organ transplant.

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  • (PMID = 17667824.001).
  • [ISSN] 0041-1337
  • [Journal-full-title] Transplantation
  • [ISO-abbreviation] Transplantation
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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55. Tuveson DA, Zhu L, Gopinathan A, Willis NA, Kachatrian L, Grochow R, Pin CL, Mitin NY, Taparowsky EJ, Gimotty PA, Hruban RH, Jacks T, Konieczny SF: Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma. Cancer Res; 2006 Jan 1;66(1):242-7
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  • [Title] Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma.
  • Despite the prevalence of oncogenic Kras mutations in the earliest stages of pancreatic ductal adenocarcinoma, the cellular compartment in which oncogenic Kras initiates tumorigenesis remains unknown.
  • To address this, we have gene targeted KrasG12D into the open reading frame of Mist1, a basic helix-loop-helix transcription factor that is expressed during pancreatic development and required for proper pancreatic acinar organization.
  • Although the pancreata of Mist1(KrasG12D/+) mutant mice predictably exhibited acinar metaplasia and dysplasia, the frequent death of these mice from invasive and metastatic pancreatic cancer with mixed histologic characteristics, including acinar, cystic, and ductal features, was unexpected and in contrast to previously described mutant mice that ectopically expressed the Kras oncogene in either acinar or ductal compartments.
  • Interestingly, many of the mutant mice developed hepatocellular carcinoma, implicating Mist1(KrasG12D/+) cells in both pancreatic and hepatic neoplasia.
  • These findings suggest that Mist1-expressing cells represent a permissive compartment for transformation by oncogenic Kras in pancreatic tumorigenesis.


56. Saber AA, Helbling B, Khaghany K, Nirmit G, Pimental R, McLeod MK: Safety zone for splenic hilar control during splenectomy: a computed tomography scan mapping of the tail of the pancreas in relation to the splenic hilum. Am Surg; 2007 Sep;73(9):890-4
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  • [Title] Safety zone for splenic hilar control during splenectomy: a computed tomography scan mapping of the tail of the pancreas in relation to the splenic hilum.
  • Inadvertent injury to the tail of the pancreas is a potentially serious but preventable complication that can occur during laparoscopic splenectomy.
  • The aim of this study was to determine the feasibility of using computed tomography to map the location of the tail of the pancreas relative to the spleen to locate a possible safe zone for splenic hilar dissection and/or hemostasis.
  • The distance from the tail of the pancreas to the hilum of the spleen was determined for each patient.
  • Computed tomography was successful in mapping the distance from the tail of the pancreas to the splenic hilum in 148 patients.
  • The average distance from the tail of the pancreas to the splenic hilum was 3.42 cm +/- 1.54 cm (95% confidence interval, 3.17-3.67).
  • During splenic vascular control, it is important to stay within 1 cm from the splenic hilum to minimize the risk of injury to the tail of the pancreas during splenectomy.
  • [MeSH-major] Laparoscopy. Pancreas / radiography. Spleen / radiography. Splenectomy / methods. Tomography, X-Ray Computed

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  • (PMID = 17939420.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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57. Pastor CM, Morel DR, Vonlaufen A, Schiffer E, Lescuyer P, Frossard JL: Delayed production of IL-18 in lungs and pancreas of rats with acute pancreatitis. Pancreatology; 2010;10(6):752-7
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  • [Title] Delayed production of IL-18 in lungs and pancreas of rats with acute pancreatitis.
  • BACKGROUND/AIMS: During acute pancreatitis, tumor necrosis factor (TNF)-α, interleukin (IL)-1 and IL-6 play a pivotal role in promoting injury in the pancreas and remote organs.
  • However, the profile of IL-18 expression in the pancreas and lung is unknown, and the aim of our study was to investigate such expression in rats with pancreatitis.
  • Pulmonary and pancreatic injury was measured by biological and histological parameters.
  • RESULTS: Pancreatic and pulmonary injury appeared within 2 h after pancreatitis induction and persisted until the end of the protocol (18 h).
  • TNF-α, IL-1 and IL-6 expression increased early in the lungs and pancreas, with a partial recovery by the end of the study.
  • [MeSH-minor] Acute Disease. Animals. Disease Models, Animal. Drug Therapy, Combination. Endotoxins / toxicity. Interleukin-1 / metabolism. Interleukin-6 / metabolism. Pancreas / drug effects. Pancreas / metabolism. Pancreas / pathology. Rats. Rats, Sprague-Dawley. Taurocholic Acid / toxicity. Tumor Necrosis Factor-alpha / metabolism

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  • [Copyright] Copyright © 2011 S. Karger AG, Basel.
  • (PMID = 21273803.001).
  • [ISSN] 1424-3911
  • [Journal-full-title] Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
  • [ISO-abbreviation] Pancreatology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Endotoxins; 0 / Interleukin-1; 0 / Interleukin-18; 0 / Interleukin-6; 0 / Tumor Necrosis Factor-alpha; 5E090O0G3Z / Taurocholic Acid
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58. Ku SK, Lee HS: Distribution and frequency of endocrine cells in the pancreas of the ddY mouse: an immunohistochemical study. Eur J Histochem; 2005 Apr-Jun;49(2):125-30
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  • [Title] Distribution and frequency of endocrine cells in the pancreas of the ddY mouse: an immunohistochemical study.
  • The regional distribution and frequency of pancreatic endocrine cells in ddY mice were studied by an immunohistochemical (peroxidase anti-peroxidase;.
  • PAP) method using four types of specific antisera against insulin, glucagon, somatostatin and human pancreatic polypeptide (hPP).
  • In the pancreatic islets, most of insulin-immunoreactive (IR) cells were located in the central portion.
  • In the exocrine pancreas, insulin-, glucagon-, somatostatin- and hPP-IR cells were detected; they occurred mainly among the exocrine parenchyma as solitary cells.
  • Cell clusters consisted of only insulin- or only glucagon-IR cells and were distributed in the pancreas parenchyma as small islets.
  • In addition, insulin- and glucagon-IR cells were also demonstrated in the pancreatic duct regions.
  • In conclusion, some strain-dependent characteristic distributional patterns of pancreatic endocrine cells were found in the ddY mouse.
  • [MeSH-major] Endocrine System / cytology. Pancreas / cytology

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  • (PMID = 15967740.001).
  • [ISSN] 1121-760X
  • [Journal-full-title] European journal of histochemistry : EJH
  • [ISO-abbreviation] Eur J Histochem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Insulin; 9007-92-5 / Glucagon
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59. Lee KY, Ahn HC, Kim C, Kim SH, Kim DK, Park HS: Pancreatic exocrine response to long-term high-fat diets in rats. JOP; 2006;7(4):397-404
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  • [Title] Pancreatic exocrine response to long-term high-fat diets in rats.
  • CONTEXT: Although the synthesis and secretion of pancreatic enzymes are dependent on the composition of diet, little is known about the long-term adaptation of the exocrine pancreas to the chronic intake of high-fat, low-carbohydrate diets.
  • OBJECTIVE: The effects of long-term (48-weeks) high-fat, low-carbohydrate feeding on the intracellular activity as well as on the secretory activities of the pancreas regarding the secretion of amylase and lipase in isolated pancreatic lobules of rats were investigated.
  • MAIN OUTCOME MEASURES: The intracellular activity of alpha-amylase and lipase were defined as enzyme activity per 1 mg protein in the pancreatic homogenate.
  • The secretory activity of the pancreatic enzymes was defined as enzyme activity per 1 mg protein or as the mean percentage of released enzyme activity in the medium to that initially retained in the lobules over the entire 90 minute incubation period.
  • RESULTS: The intracellular activity as well as the secretory activities of pancreatic amylase in the basal and in the cholecystokinin (10 pmol/L)-stimulated states of high-fat, low-carbohydrate diet fed rats were significantly lower than that in the control rats.
  • CONCLUSIONS: The reduction of the intracellular amylase activity and the secretory amylase activity may be a long-term adaptive response of the pancreas to the reduced carbohydrate composition of the diets.
  • However, we failed to observe a long-term adaptive response of pancreatic lipase to increased fat composition of diets.
  • [MeSH-major] Amylases / metabolism. Dietary Fats / pharmacology. Pancreas, Exocrine / drug effects. Pancreas, Exocrine / enzymology

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  • (PMID = 16832137.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Dietary Fats; 9011-97-6 / Cholecystokinin; EC 3.1.1.3 / Lipase; EC 3.2.1.- / Amylases
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60. Konishi M, Kinoshita T, Nakagohri T, Takahashi S, Gotohda N, Ryu M: Pancreas-sparing duodenectomy for duodenal neoplasms including malignancies. Hepatogastroenterology; 2007 Apr-May;54(75):753-7
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  • [Title] Pancreas-sparing duodenectomy for duodenal neoplasms including malignancies.
  • BACKGROUND/AIMS: Pancreas-sparing duodenectomy (PSD) represents an attractive operation for benign or premalignant duodenal disease.
  • METHODOLOGY: The present study investigated 16 patients who underwent PSD for duodenal neoplasms including adenoma, cancer, carcinoid and non-epithelial tumor.
  • This study classified PSD into 4 types based on the resected portion of the duodenum, as used in gastrectomy (total, subtotal, distal, and proximal) and we experienced pancreas-sparing proximal duodenectomy and pancreas-sparing distal duodenectomy.
  • RESULTS: Pancreatic fistula or anastomotic leak occurred in 2 patients, and were closed with nonoperative management.
  • The remaining 10 patients are well, with no symptoms related to the hepatobiliary and pancreatic systems.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Male. Middle Aged. Postoperative Complications / diagnosis. Treatment Outcome

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  • (PMID = 17591055.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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61. Dib MJ, Ho KJ, Hanto DW, Karp SJ, Johnson SR: Roux limb volvulus after pancreas transplantation: an unusual cause of pancreatic graft loss. Clin Transplant; 2009 Nov-Dec;23(6):807-11
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  • [Title] Roux limb volvulus after pancreas transplantation: an unusual cause of pancreatic graft loss.
  • Pancreas transplantation with enteric drainage avoids the long-term urological complications of bladder drainage.
  • This report describes a patient five yr after left-sided pancreas transplant with Roux-en-Y enteric drainage, presenting with abdominal pain, leukocytosis and radiological evidence of bowel obstruction.
  • Exploration revealed a volvulus of the Roux limb as it passed through the mesocolon, with necrosis of the allograft duodenum and marked congestion of the pancreas.
  • This is the first report of pancreas graft loss due to this entity, which should be recognized as an unusual cause of abdominal pain after pancreas transplantation.
  • Potential bowel complications related to the sigmoid mesentery in left-sided pancreas transplantation are additional reasons for right-sided placement of the pancreas allograft.
  • [MeSH-major] Graft Rejection / etiology. Intestinal Volvulus / complications. Pancreas Transplantation / adverse effects

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  • (PMID = 19191816.001).
  • [ISSN] 1399-0012
  • [Journal-full-title] Clinical transplantation
  • [ISO-abbreviation] Clin Transplant
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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62. Kodama S, Davis M, Faustman DL: Diabetes and stem cell researchers turn to the lowly spleen. Sci Aging Knowledge Environ; 2005 Jan 19;2005(3):pe2
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  • Long seen as superfluous, the adult spleen of the mouse has recently been shown to hold stem cells that, in diabetic mice or genetically altered mice that lack a pancreas, effectively regenerate insulin-producing islet cells of the pancreas.
  • [MeSH-minor] Aging. Animals. Cell Lineage. Homeodomain Proteins / metabolism. Islets of Langerhans / cytology. Islets of Langerhans Transplantation. Mice. Pancreas / cytology. Pancreas / embryology. RNA, Messenger / metabolism. Stem Cells / cytology. Stem Cells / metabolism

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  • (PMID = 15659719.001).
  • [ISSN] 1539-6150
  • [Journal-full-title] Science of aging knowledge environment : SAGE KE
  • [ISO-abbreviation] Sci Aging Knowledge Environ
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / RNA, Messenger; 0 / Tlx1 protein, mouse
  • [Number-of-references] 61
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63. Oikarinen M, Tauriainen S, Honkanen T, Vuori K, Karhunen P, Vasama-Nolvi C, Oikarinen S, Verbeke C, Blair GE, Rantala I, Ilonen J, Simell O, Knip M, Hyöty H: Analysis of pancreas tissue in a child positive for islet cell antibodies. Diabetologia; 2008 Oct;51(10):1796-802
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  • [Title] Analysis of pancreas tissue in a child positive for islet cell antibodies.
  • AIMS/HYPOTHESIS: Type 1 diabetes is caused by an immune-mediated process, reflected by the appearance of autoantibodies against pancreatic islets in the peripheral circulation.
  • The present study assesses whether positivity for a single autoantibody correlates with pathological changes in the pancreas.
  • METHODS: We studied post mortem pancreatic tissue of a child who repeatedly tested positive for islet cell antibodies (ICA) in serial measurements.
  • RESULTS: The structure of the pancreas did not differ from normal.
  • Beta-2-microglobulin and CAR were strongly produced in the islets, but not in the exocrine pancreas.
  • However, it is most likely that the pancreatic islets were infected by an enterovirus in this child.
  • [MeSH-major] Autoantibodies / immunology. Islets of Langerhans / immunology. Pancreas / immunology

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  • (PMID = 18696046.001).
  • [ISSN] 0012-186X
  • [Journal-full-title] Diabetologia
  • [ISO-abbreviation] Diabetologia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Viral; 0 / Antigens, CD; 0 / Antigens, CD3; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Autoantibodies; 0 / CD68 antigen, human; 0 / Insulin; 0 / Interferon-alpha; 0 / Receptors, Virus; 0 / adenovirus receptor; 0 / islet cell antibody; 51110-01-1 / Somatostatin; 9007-92-5 / Glucagon; EC 1.14.99.1 / Cyclooxygenase 2
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64. Gold DV, Stein R, Burton J, Goldenberg DM: Enhanced expression of CD74 in gastrointestinal cancers and benign tissues. Int J Clin Exp Pathol; 2010;4(1):1-12
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  • [Title] Enhanced expression of CD74 in gastrointestinal cancers and benign tissues.
  • CD74 expression was observed in 95% of pancreatic carcinomas with the majority of cases presenting a mostly intense, diffuse labeling pattern.
  • These findings are supportive of a role for CD74 in the development and maintenance of gastrointestinal neo-plasia, and provide a rationale for development of therapeutic agents that are able to block CD74 function, specifically within the tumor cell.
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Colorectal Neoplasms / metabolism. Colorectal Neoplasms / pathology. Humans. Immunohistochemistry. Pancreatic Neoplasms / metabolism. Pancreatic Neoplasms / pathology. Stomach Neoplasms / metabolism. Stomach Neoplasms / pathology. Tissue Array Analysis

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  • (PMID = 21228923.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA096924
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Differentiation, B-Lymphocyte; 0 / Biomarkers, Tumor; 0 / Histocompatibility Antigens Class II; 0 / invariant chain
  • [Other-IDs] NLM/ PMC3016099
  • [Keywords] NOTNLM ; CD74 / colon carcinoma / gastric carcinoma / invariant chain / pancreatic carcinoma
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65. Friebe V, Keck T, Mattern D, Schmitt-Graeff A, Werner M, Mikami Y, Adam U, Hopt UT: Serous cystadenocarcinoma of the pancreas: management of a rare entity. Pancreas; 2005 Aug;31(2):182-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serous cystadenocarcinoma of the pancreas: management of a rare entity.
  • Whereas mucinous cystadenomas of the pancreas are considered premalignant, serous cystadenomas are believed to remain benign.
  • We present a case of an 80-year-old woman with a primary tumor of the pancreas that was histologically classified as serous cystadenocarcinoma.
  • [MeSH-major] Cystadenocarcinoma, Serous / secondary. Cystadenocarcinoma, Serous / surgery. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery

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  • (PMID = 16025006.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Cosentini V, Angione V, Lo Cicero A, Ferraro-Mortellaro R, Barillà A, Floccari F: [Recurrent multifocal cancer lesions in a patient on hemodialysis after kidney pancreas transplant failure]. G Ital Nefrol; 2010 May-Jun;27(3):301-5
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  • [Title] [Recurrent multifocal cancer lesions in a patient on hemodialysis after kidney pancreas transplant failure].
  • [Transliterated title] Lesioni neoplastiche multifocali e recidivanti in un paziente in emodialisi dopo fallimento di trapianto combinato rene-pancreas.
  • A 59-year-old man, ex-smoker, who had been on hemodialysis for seven months because of uremic degeneration of diabetic nephropathy, underwent a combined kidney-pancreas transplant in 1991, complicated by slow-resolution CMV infection.
  • In 1993, after kidney graft failure due to chronic rejection, hemodialysis treatment was restarted with good pancreatic function.
  • [MeSH-major] Carcinoma, Squamous Cell. Kidney Transplantation. Mouth Neoplasms. Neoplasm Recurrence, Local. Pancreas Transplantation. Renal Dialysis. Skin Neoplasms


67. Oida T, Mimastu K, Kawasaki A, Kuboi Y, Kano H, Amano S: Toward zero pancreatic leakage after pancreaticoduodenectomy for soft pancreas in low-volume pancreatic surgery centers. Hepatogastroenterology; 2009 May-Jun;56(91-92):886-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Toward zero pancreatic leakage after pancreaticoduodenectomy for soft pancreas in low-volume pancreatic surgery centers.
  • Pancreatic leakage continues to occur after pancreaticoduodenectomy (PD) and it is a serious problem.
  • It has been proposed that a normal-sized, soft, friable, and functionally normal pancreas with a thin-walled main pancreatic duct is at a greater risk of anastomotic leakage.
  • However, despite the evaluation of various improvised procedures, pancreatic leakage persists as a complication.
  • Here, we describe our PD technique that facilitates the prevention of pancreatic leakage.
  • Our operative procedures includes 3 stages: pancreaticogastrostomy (PG), external and continuous suction drainage of pancreatic juice, and wrapping of the pancreatic anastomosis by using round ligament and applying fibrin glue sealant to the surface of the pancreatic anastomosis.
  • Twenty-six patients with periampullary malignancy with soft pancreas underwent PG without any pancreatic leakage or fistula.
  • The combined procedures, including PG, total external drainage with continuous suction of the pancreatic juice, and wrapping of the pancreatic anastomotic site by using round ligament is a useful method to prevent pancreatic leakage for cases of soft pancreas in pancreatic centers that do not encounter many such cases.
  • [MeSH-major] Ampulla of Vater. Bile Duct Neoplasms / surgery. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods

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  • (PMID = 19621723.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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68. Mori Y, Ohtsuka T, Tsutsumi K, Yasui T, Sadakari Y, Ueda J, Takahata S, Nakamura M, Tanaka M: Multifocal pancreatic ductal adenocarcinomas concomitant with intraductal papillary mucinous neoplasms of the pancreas detected by intraoperative pancreatic juice cytology. A case report. JOP; 2010;11(4):389-92
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  • [Title] Multifocal pancreatic ductal adenocarcinomas concomitant with intraductal papillary mucinous neoplasms of the pancreas detected by intraoperative pancreatic juice cytology. A case report.
  • CONTEXT: Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas have been detected with increasing frequency as a result of the progression of diagnostic modalities.
  • Recently, invasive ductal carcinoma of the pancreas concomitant with IPMNs has been the focus of attention.
  • CASE REPORT: We report the case of a 57-year-old man with multifocal ductal carcinomas of the pancreas concomitant with IPMNs detected by intraoperative cytology.
  • During a follow-up for branch duct IPMNs, a stenotic lesion of the main duct in the pancreatic body was found by ERCP, and brush cytology of the stenosis revealed an adenocarcinoma.
  • A distal pancreatectomy was proposed; however, intraoperative pancreatic juice cytology from the pancreatic head also revealed adenocarcinoma, and a total pancreatectomy was finally carried out.
  • Pathological examination of the resected specimen showed multifocal ductal carcinomas and IPMNs in the distal pancreas, and invasive ductal carcinoma in the pancreatic head which had not been detected by preoperative imaging studies.
  • Intraoperative pancreatic juice cytology should always be performed in order to confirm the absence of carcinoma in the pancreas to be left in place after planned resection.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Papillary / diagnosis. Neoplasms, Multiple Primary / diagnosis. Pancreatic Juice / cytology. Pancreatic Neoplasms / diagnosis

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  • (PMID = 20601817.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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69. DeWitt J, Sherman S, Al-Haddad M, McHenry L, Cote GA, Leblanc JK: EUS-guided FNA of local recurrence of pancreatic cancer after surgical resection. Gastrointest Endosc; 2010 Nov;72(5):1076-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] EUS-guided FNA of local recurrence of pancreatic cancer after surgical resection.
  • BACKGROUND: EUS-guided FNA (EUS-FNA) is a sensitive test for the preoperative diagnosis of pancreatic cancer.
  • Its use for diagnosing local tumor recurrence after surgical resection has not been described.
  • PATIENTS: Consecutive patients referred for EUS with clinical and/or radiographic suspicion of pancreatic cancer recurrence.
  • RESULTS: Seventeen patients (9 male, median age 71 years) underwent EUS at a median of 17 months (range 7-46 months) after a classic Whipple procedure (n = 7), pylorus-sparing Whipple procedure (n = 7), or distal pancreatectomy (n = 3) for suspected local recurrence of pancreatic cancer.
  • The primary tumor (median size 2.5 cm, range 1.5-7.9 cm) was located in the head in 14 patients, the body in 1, and the tail in 2.
  • Transgastric EUS-FNA (n = 16, median 4.5 passes, range 2-10) disclosed recurrent malignancy in 13 of 16 (79%), atypical cells in 1 of 16 (7%), and benign cytology in 2 of 16 (14%).
  • Subsequent radiographic evidence of increasing tumor burden was seen in 1 of 2 patients with benign cytology; however, follow-up for the 2 other patients with benign biopsy specimens was not available.
  • Depending on the status of the 2 patients without available follow-up, the sensitivity, specificity, and accuracy of EUS-FNA for the diagnosis of recurrent cancer ranged from 81% to 93%, was 100%, and ranged from 81% to 93%, respectively.
  • CONCLUSIONS: EUS-FNA is sensitive for the diagnosis of retroperitoneal recurrence of pancreatic cancer after surgical resection.
  • [MeSH-major] Biopsy, Fine-Needle. Endosonography. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / ultrasonography. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / ultrasonography

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  • [Copyright] Copyright © 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20869713.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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70. Davenport C, Hamid N, O'Sullivan EP, Daly P, Mohan P, Little D, Thompson CJ, Agha A, Hickey D, Smith D: The impact of pancreas and kidney transplant on cardiovascular risk factors (analyzed by mode of immunosuppression and exocrine drainage). Clin Transplant; 2009 Sep-Oct;23(5):616-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The impact of pancreas and kidney transplant on cardiovascular risk factors (analyzed by mode of immunosuppression and exocrine drainage).
  • INTRODUCTION: The aim of this study was to determine the cardiovascular (CV) risk factor response in Irish patients with type 1 diabetes following simultaneous pancreas and kidney transplantation (SPK), analyzing response based on mode of immunosuppression and surgical drainage in a uniquely homogenous population.
  • METHODS: A retrospective review of SPKs carried out between 1993 and 2005 in the National Renal and Pancreatic Centre of Ireland was performed.
  • [MeSH-major] Cardiovascular Diseases / etiology. Diabetes Mellitus, Type 1 / surgery. Graft Rejection / prevention & control. Kidney Failure, Chronic / surgery. Kidney Transplantation. Pancreas Transplantation. Postoperative Complications


71. Manáková E, Titlbach M: Development of the chick pancreas with regard to estimation of the relative occurrence and growth of endocrine tissue. Anat Histol Embryol; 2007 Apr;36(2):127-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Development of the chick pancreas with regard to estimation of the relative occurrence and growth of endocrine tissue.
  • Endocrine cells in chick pancreas were observed to map their distribution during development and to perform morphometric studies starting on embryonic day 5.
  • Endocrine elements were also scattered as single cells over the pancreas.
  • [MeSH-major] Chick Embryo. Pancreas / cytology. Pancreas / embryology

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  • (PMID = 17371386.001).
  • [ISSN] 0340-2096
  • [Journal-full-title] Anatomia, histologia, embryologia
  • [ISO-abbreviation] Anat Histol Embryol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Insulin; 51110-01-1 / Somatostatin; 9007-92-5 / Glucagon
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72. Monstein HJ, Grahn N, Ohlsson B: Proenkephalin-A mRNA is widely expressed in tissues of the human gastrointestinal tract. Eur Surg Res; 2006;38(5):464-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: The present study demonstrates proenkephalin-A mRNA expression in the human esophagus, gastrointestinal tract, pancreas, and gallbladder.
  • CONCLUSION: The present study demonstrates proenkephalin-A mRNA expression in regions of the human esophagus, gastrointestinal tract, pancreas, and gallbladder tissues which provides information for the future mapping of proenkephalin-A mRNA and protein expression/co-expression at the cellular level.
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Gallbladder / metabolism. Gene Expression. Humans. Male. Middle Aged. Pancreas / metabolism. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • [Copyright] Copyright (c) 2006 S. Karger AG, Basel.
  • (PMID = 16940731.001).
  • [ISSN] 0014-312X
  • [Journal-full-title] European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes
  • [ISO-abbreviation] Eur Surg Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Enkephalins; 0 / Protein Precursors; 0 / RNA, Messenger; 0 / proenkephalin
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73. Ihse I, Andersson R, Ask A, Ewers SB, Lindell G, Tranberg KG: Intraoperative radiotherapy for patients with carcinoma of the pancreas. Pancreatology; 2005;5(4-5):438-42
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  • [Title] Intraoperative radiotherapy for patients with carcinoma of the pancreas.
  • BACKGROUND/AIMS: Local recurrence is one of the most common sites of failure after resection of exocrine pancreatic adenocarcinoma.
  • Intraoperative radiotherapy (IORT) involves delivery of high doses of irradiation to the pancreas in patients with locally advanced disease, and to the surgical bed following pancreatic resection while uninvolved and dose-limiting tissues are displaced.
  • Here we report our current experience with IORT in patients with pancreatic cancer.
  • The cancer diagnosis was verified histologically and/or cytologically in all patients.
  • CONCLUSION: In this nonrandomized study no apparent beneficial effects were seen after IORT in patients with pancreatic cancer, neither adjuvantly nor palliatively.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Adenocarcinoma / surgery. Intraoperative Care. Pancreatic Neoplasms / radiotherapy. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Palliative Care. Postoperative Complications. Retrospective Studies. Survival Rate

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  • [Copyright] Copyright 2005 S. Karger AG, Basel and IAP.
  • (PMID = 15985769.001).
  • [ISSN] 1424-3903
  • [Journal-full-title] Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
  • [ISO-abbreviation] Pancreatology
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Switzerland
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74. Magno L, Sivero L, Napolitano V, Ruggiero S, Fontanarosa G, Massa S: [The role of endoscopy in gastroenteropancreatic neuroendocrine tumors]. G Chir; 2010 Jun-Jul;31(6-7):341-3
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  • Massa I tumori neuroendocrini (NET) gastro-entero-pancreatici (GEP) sono neoplasie rare che originano dalle cellule neuroendocrine del tubo digerente e del pancreas.
  • Massa Gastroenteropancreatic (GEP) neuroendocrine tumors (NET) are rare neoplasia arisen from neuroendocrine cells present in the gut mucosa and pancreas.
  • Digestive endoscopy and endoscopic ultrasonography play a relevant role in NET diagnosis, stadiation and surveillance.
  • [MeSH-major] Endoscopy, Gastrointestinal. Endosonography. Gastrointestinal Neoplasms / diagnosis. Neuroendocrine Tumors / diagnosis. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Duodenoscopy / methods. Humans. Neoplasm Staging. Predictive Value of Tests. Sensitivity and Specificity. Treatment Outcome

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  • (PMID = 20646389.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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75. Matrone A, Russo M, Mollica C, Lombardi D, Lombardi G, Maurea S, Imbriaco M: Lymphoepithelial pancreatic cyst: an atypical benign pancreatic mass presenting with a "cheerios-like" appearance. JOP; 2010;11(2):170-2
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  • [Title] Lymphoepithelial pancreatic cyst: an atypical benign pancreatic mass presenting with a "cheerios-like" appearance.
  • CONTEXT: Lymphoepithelial cyst of the pancreas is a rare benign lesion which often presents as an incidental radiological finding, but may cause symptoms, such as abdominal pain and nausea.
  • It can occur at any location in the pancreas.
  • The differential diagnosis includes primary splenic cysts, pseudocysts, mucinous cystic neoplasms of the pancreas, left adrenal cysts, duplication cysts and retroperitoneal cysts.
  • Some of these diagnoses can be excluded by MRI; however, for the final diagnosis, fine needle aspiration or surgical resection may be necessary.
  • CASE REPORT: We report a rare case of a pancreatic lymphoepithelial cyst in an asymptomatic 63-year-old man, discovered in a clinical follow-up for colon cancer.
  • CONCLUSION: This particular finding could help in the differential diagnosis of this benign lesion from other pancreatic masses.
  • [MeSH-major] Pancreatic Cyst / diagnosis. Pancreatic Cyst / pathology
  • [MeSH-minor] Diagnosis, Differential. Edible Grain. Epidermal Cyst / pathology. Humans. Lymphocele / pathology. Male. Middle Aged. Organ Size. Pancreas / pathology. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / pathology

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  • (PMID = 20208329.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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76. Takada H, Nakazawa T, Ohara H, Ando T, Hayashi K, Naito I, Okumura F, Tanaka H, Yamada T, Takahashi S, Joh T: Role of osteopontin in calcification in autoimmune pancreatitis. Dig Dis Sci; 2009 Apr;54(4):793-801
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: The aim of the present study was to determine the potential for pancreatic calcification in autoimmune pancreatitis by investigating osteopontin and CD44 expression.
  • METHODS: Human pancreatic tissues in normal pancreas, chronic pancreatitis, and autoimmune pancreatitis were obtained from the surgical specimens of 42 patients.
  • Pancreatic tissues from male Wistar Bonn/Kobori rats were also used as an animal autoimmune pancreatitis model.
  • RESULTS: The incidences of osteopontin expression in centroacinar cells in chronic pancreatitis with calcification and in autoimmune pancreatitis were significantly greater than that in normal pancreas (P < 0.05).
  • CONCLUSIONS: These results suggest that autoimmune pancreatitis has the potential for pancreatic calcification over a long-term clinical course.
  • [MeSH-major] Antigens, CD44 / metabolism. Calcinosis / metabolism. Osteopontin / metabolism. Pancreas / metabolism. Pancreatitis, Chronic / metabolism

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  • (PMID = 18651220.001).
  • [ISSN] 1573-2568
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD44; 106441-73-0 / Osteopontin
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77. Takahashi H, Delacruz V, Sarwar S, Selvaggi G, Moon J, Nishida S, Weppler D, Levi D, Kato T, Tzakis A, Ruiz P: Contemporaneous chronic rejection of multiple allografts with principal pancreatic involvement in modified multivisceral transplantation. Pediatr Transplant; 2007 Jun;11(4):448-52
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  • [Title] Contemporaneous chronic rejection of multiple allografts with principal pancreatic involvement in modified multivisceral transplantation.
  • The patient was a 10 yr-old-male with short gut syndrome secondary to Hirschsprung's disease, who underwent a modified (no liver) multivisceral transplant (stomach, pancreas, small and large intestine).
  • Re-transplantation of a multivisceral transplant (stomach, pancreas, liver, small and large intestine) was performed.
  • Microscopic examinations of the explanted allograft organ block revealed varying degrees of chronic rejection in many of the organs but with the pancreatic allograft being affected most severely.
  • The malabsorption symptom following the first transplant may have been caused by the early onset of chronic pancreatic allograft dysfunction.
  • Our case indicates varying severity of chronic rejection among multiple allografts where the pancreatic allograft appeared most susceptible to chronic rejection.
  • [MeSH-major] Graft Rejection / complications. Organ Transplantation / methods. Pancreatic Diseases / etiology
  • [MeSH-minor] Child. Chronic Disease. Duodenum / transplantation. Follow-Up Studies. Hirschsprung Disease / surgery. Humans. Intestine, Large / transplantation. Intestine, Small / transplantation. Male. Pancreas Transplantation / methods. Reoperation. Severity of Illness Index


78. Soga T, Ohishi T, Matsui T, Saito T, Matsumoto M, Takasaki J, Matsumoto S, Kamohara M, Hiyama H, Yoshida S, Momose K, Ueda Y, Matsushime H, Kobori M, Furuichi K: Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor. Biochem Biophys Res Commun; 2005 Jan 28;326(4):744-51
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  • LPC has been reported to induce insulin secretion from pancreatic beta-cells, however, the precise mechanism has remained elusive to date.
  • LPC potently enhances insulin secretion in response to high concentrations of glucose in the perfused rat pancreas via stimulation of adenylate cyclase, and dose-dependently induces intracellular cAMP accumulation and insulin secretion in a mouse pancreatic beta-cell line, NIT-1 cells.
  • The Gs-protein-coupled receptor for LPC was identified as GPR119, which is predominantly expressed in the pancreas.
  • [MeSH-minor] Animals. Cell Line. Dose-Response Relationship, Drug. Hormones / metabolism. Humans. In Vitro Techniques. Male. Organ Specificity. Pancreas. Rats. Rats, Wistar. Tissue Distribution


79. Kobinger GP, Deng S, Louboutin JP, Vatamaniuk M, Rivera VM, Lian MM, Markmann JF, Clackson T, Raper SE, Matschinsky F, Wilson JM: Pharmacologically regulated regeneration of functional human pancreatic islets. Mol Ther; 2005 Jan;11(1):105-11
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  • [Title] Pharmacologically regulated regeneration of functional human pancreatic islets.
  • Limited availability of donor pancreas tissues restricts the application of this therapeutic modality to a subset of eligible recipients.
  • In an attempt to expand the utility of available donor human pancreas tissue, we developed a method to stimulate the proliferation of insulin-secreting beta-cells within human islets.

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  • (PMID = 15585411.001).
  • [ISSN] 1525-0016
  • [Journal-full-title] Molecular therapy : the journal of the American Society of Gene Therapy
  • [ISO-abbreviation] Mol. Ther.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / P30 DK47757
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Blood Glucose
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80. Zhang QF, Bai YQ: [Dynamic change in microcirculation of pancreas after experimental high-voltage electric burn]. Zhonghua Shao Shang Za Zhi; 2009 Oct;25(5):368-71
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  • [Title] [Dynamic change in microcirculation of pancreas after experimental high-voltage electric burn].
  • OBJECTIVE: To observe the changes in surface microcirculation of pancreas after high-voltage electric burn (HEB).
  • The morphology of the pancreas microvessels and its surrounding tissues, and the dynamic changes in microvascular blood flow were observed with WX-9 microscope and its image analytical system.
  • Arteriole, venule and capillary network on the surface of pancreatic lobules of rabbits in both groups were clearly seen and well-distributed in the natural way before HEB.
  • There was no exudation and bleeding around the microvessels on the pancreas surface of rabbits in both groups before HEB.
  • CONCLUSIONS: HEB produces microcirculation disturbance and functional disturbance of pancreas.
  • [MeSH-major] Burns, Electric / pathology. Microcirculation. Pancreas / blood supply

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  • (PMID = 19951561.001).
  • [ISSN] 1009-2587
  • [Journal-full-title] Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns
  • [ISO-abbreviation] Zhonghua Shao Shang Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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81. Chen S, Li C, Yuan G, Xie F: Anatomical and histological observation on the pancreas in adult zebrafish. Pancreas; 2007 Jan;34(1):120-5
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  • [Title] Anatomical and histological observation on the pancreas in adult zebrafish.
  • OBJECTIVES: To investigate the anatomic structure of the pancreas and the distribution of the islets in adult zebrafish.
  • RESULTS: The pancreas along the intestine included 4 relatively independent and concentrated lobes, in which 4 kinds of islets-principal islets, Brockmann bodies, diffusely existing islets, and single beta-cell-were observed.
  • The different islets were differently distributed in the 4 pancreatic lobes with statistical significance (P < 0.05).
  • CONCLUSIONS: According to the distinct distribution, concentration of the pancreas, and different contents of the islets within the pancreas, 4 lobes of the pancreas along the intestine-the gallbladder-spleen lobe, the middle lobe, the left lobe, and the ventral lobe-were identified in adult zebrafish.
  • [MeSH-major] Glucagon-Secreting Cells / cytology. Insulin-Secreting Cells / cytology. Pancreas, Exocrine / anatomy & histology. Zebrafish / anatomy & histology

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  • (PMID = 17198193.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Insulin; 9007-92-5 / Glucagon
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82. Dixon E, Pasieka JL: Functioning and nonfunctioning neuroendocrine tumors of the pancreas. Curr Opin Oncol; 2007 Jan;19(1):30-5
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  • [Title] Functioning and nonfunctioning neuroendocrine tumors of the pancreas.
  • PURPOSE OF REVIEW: Neuroendocrine tumors of the pancreas are a small subgroup of tumors characterized by a variety of biological behaviors.
  • With recent advances in diagnosis and staging, the treatment options for all neuroendocrine tumors have evolved.
  • Presented here is a review of the current-day knowledge for neuroendocrine tumors of the pancreas.
  • RECENT FINDINGS: A consensus by leading experts in the neuroendocrine tumors field has proposed an algorithm for the diagnosis, treatment and follow-up of these rare tumors.
  • Contrary to adenocarcinoma of the pancreas, hormonal and biotherapy offer unique treatment strategies for these rare tumors.
  • SUMMARY: Presented here is a summary of the recent literature on the diagnosis and treatment of neuroendocrine tumors of the pancreas.
  • [MeSH-major] Neuroendocrine Tumors / physiopathology. Pancreatic Neoplasms / physiopathology

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  • (PMID = 17133109.001).
  • [ISSN] 1040-8746
  • [Journal-full-title] Current opinion in oncology
  • [ISO-abbreviation] Curr Opin Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 46
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83. Huszarik K, Wright B, Keller C, Nikoopour E, Krougly O, Lee-Chan E, Qin HY, Cameron MJ, Gurr WK, Hill DJ, Sherwin RS, Kelvin DJ, Singh B: Adjuvant immunotherapy increases beta cell regenerative factor Reg2 in the pancreas of diabetic mice. J Immunol; 2010 Nov 1;185(9):5120-9
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  • [Title] Adjuvant immunotherapy increases beta cell regenerative factor Reg2 in the pancreas of diabetic mice.
  • Insulin-producing β cells can partially regenerate in adult pancreatic tissues, both in human and animal models of type 1 diabetes (T1D).
  • In this study, we investigated factors involved in the regeneration of β cells in the pancreas of NOD mice during diabetes development and after treatment with adjuvants.
  • Reg2 expression was found to be upregulated in pancreatic islets both during diabetes development and as a result of adjuvant treatment in diabetic NOD mice and in C57BL/6 mice made diabetic by streptozotocin treatment.
  • We also observed upregulation of Reg2 in the pancreas of diabetic mice undergoing β cell regenerative therapy with exendin-4 or with islet neogenesis-associated protein.
  • Reg2 expression following adjuvant treatment correlated with a reduction in insulitis, an increase in insulin secretion, and an increase in the number of small islets in the pancreas of diabetic NOD mice and with improved glucose tolerance tests in streptozotocin-treated diabetic C57BL/6 mice.
  • [MeSH-major] Adjuvants, Immunologic / pharmacology. Diabetes Mellitus, Type 1 / metabolism. Immunotherapy / methods. Insulin-Secreting Cells / metabolism. Pancreas / physiology. Proteins / metabolism

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  • (PMID = 20876350.001).
  • [ISSN] 1550-6606
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Grant] Canada / Canadian Institutes of Health Research / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Pap protein, mouse; 0 / Proteins; 9007-81-2 / Freund's Adjuvant
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84. Reddy S, Wolfgang CL: Solid pseudopapillary neoplasms of the pancreas. Adv Surg; 2009;43:269-82
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  • [Title] Solid pseudopapillary neoplasms of the pancreas.
  • SPN is a rare neoplasm that affects mainly young women.
  • The genetic mechanism behind the development of SPN is distinct from the more lethal ductal carcinoma of the pancreas.

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  • (PMID = 19845185.001).
  • [ISSN] 0065-3411
  • [Journal-full-title] Advances in surgery
  • [ISO-abbreviation] Adv Surg
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 52
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85. Lee NK, Kim S, Jeon TY, Kim HS, Kim DH, Seo HI, Park DY, Jang HJ: Complications of congenital and developmental abnormalities of the gastrointestinal tract in adolescents and adults: evaluation with multimodality imaging. Radiographics; 2010 Oct;30(6):1489-507
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  • The imaging features at radiography, fluoroscopy, ultrasonography, computed tomography, and magnetic resonance imaging may help identify congenital gastrointestinal anomalies such as congenital esophageal stenosis, gastric volvulus, duodenal web, annular pancreas, heterotopic pancreas, cecal volvulus, anomalies of the omphalomesenteric duct, Hirschsprung disease, and gastrointestinal duplication cyst.
  • Familiarity with the imaging features of the various congenital anomalies of the gastrointestinal tract and their complications is important to establish the correct diagnosis and determine appropriate treatment, which is critical to avoid life-threatening complications.
  • [MeSH-major] Diagnostic Imaging. Digestive System Abnormalities / complications. Digestive System Abnormalities / diagnosis
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Gastrointestinal Tract / abnormalities. Gastrointestinal Tract / embryology. Humans

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  • [Copyright] © RSNA, 2010.
  • (PMID = 21071371.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
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86. Wallace K, Marek CJ, Currie RA, Wright MC: Exocrine pancreas trans-differentiation to hepatocytes--a physiological response to elevated glucocorticoid in vivo. J Steroid Biochem Mol Biol; 2009 Aug;116(1-2):76-85
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  • [Title] Exocrine pancreas trans-differentiation to hepatocytes--a physiological response to elevated glucocorticoid in vivo.
  • Damage or ectopic expression of some growth factors can lead to the appearance of hepatocyte-like cells within the pancreas.
  • Since glucocorticoids promote liver hepatocyte phenotype in vitro, the effect of glucocorticoid on pancreatic differentiation in vivo was examined.
  • Using a plastic pancreatic acinar cell line, this response was shown to be associated with changes in the regulation of WNT signalling-related gene expression and a repression of WNT signalling activity.
  • These data suggest that a pathological response of the pancreas in vivo to elevated glucocorticoid is a differentiation of exocrine pancreatic cells or pancreatic progenitor cells to an hepatocyte-like phenotype.
  • [MeSH-major] Cell Differentiation. Glucocorticoids / metabolism. Hepatocytes / cytology. Pancreas, Exocrine / cytology

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  • (PMID = 19446026.001).
  • [ISSN] 1879-1220
  • [Journal-full-title] The Journal of steroid biochemistry and molecular biology
  • [ISO-abbreviation] J. Steroid Biochem. Mol. Biol.
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Glucocorticoids
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87. Meagher C, Tang Q, Fife BT, Bour-Jordan H, Wu J, Pardoux C, Bi M, Melli K, Bluestone JA: Spontaneous development of a pancreatic exocrine disease in CD28-deficient NOD mice. J Immunol; 2008 Jun 15;180(12):7793-803
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  • [Title] Spontaneous development of a pancreatic exocrine disease in CD28-deficient NOD mice.
  • Autoimmune pancreatitis (AIP) is a heterogeneous autoimmune disease in humans characterized by a progressive lymphocytic and plasmacytic infiltrate in the exocrine pancreas.
  • NOD mouse AIP was associated with severe periductal and parenchymal inflammation of the exocrine pancreas by CD4(+) T cells, CD8(+) T cells, and B cells.
  • Autoantibodies and autoreactive T cells from affected mice recognized a approximately 50-kDa protein identified as pancreatic amylase.
  • The establishment and characterization of this spontaneous pancreatic amylase-specific AIP in regulatory T cell-deficient NOD.CD28KO mice provides an excellent model for the study of disease pathogenesis and development of new therapies for human autoimmune pancreatitis.

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  • (PMID = 18523243.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / P30 DK063720; United States / NIAID NIH HHS / AI / R01 AI 50834-02; United States / NIDDK NIH HHS / DK / P01 DK049799-039001; United States / NIAID NIH HHS / AI / AI050834-05; United States / NIAID NIH HHS / AI / U19 AI056388; United States / NIDDK NIH HHS / DK / P30 DK063720-01; United States / NIDDK NIH HHS / DK / P30 DK 63720; United States / NIDDK NIH HHS / DK / DK049799-039001; United States / NIDDK NIH HHS / DK / DK063720-01; United States / NIAID NIH HHS / AI / U19 AI 056388; United States / NIAID NIH HHS / AI / R01 AI050834-05; United States / NIAID NIH HHS / AI / R01 AI050834; United States / NIDDK NIH HHS / DK / P01 DK049799
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD28; 0 / Autoantigens; EC 3.2.1.1 / alpha-Amylases
  • [Other-IDs] NLM/ NIHMS48371; NLM/ PMC2429990
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88. Razavi R, Chan Y, Afifiyan FN, Liu XJ, Wan X, Yantha J, Tsui H, Tang L, Tsai S, Santamaria P, Driver JP, Serreze D, Salter MW, Dosch HM: TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes. Cell; 2006 Dec 15;127(6):1123-35
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  • In type 1 diabetes, T cell-mediated death of pancreatic beta cells produces insulin deficiency.
  • However, what attracts or restricts broadly autoreactive lymphocyte pools to the pancreas remains unclear.
  • We report that TRPV1(+) pancreatic sensory neurons control islet inflammation and insulin resistance.
  • Delivering the neuropeptide substance P by intra-arterial injection into the NOD pancreas reverses abnormal insulin resistance, insulitis, and diabetes for weeks.


89. Gécz J, Cloosterman D, Partington M: ARX: a gene for all seasons. Curr Opin Genet Dev; 2006 Jun;16(3):308-16
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  • The Aristaless-related homeobox gene, ARX, is an important transcription factor with a crucial role in forebrain, pancreas and testes development.
  • Pax4 was identified as one of the ARX target genes, and both proteins have crucial functions in endocrine mouse pancreas alpha-cell and beta-cell lineage specification.
  • [MeSH-minor] Animals. Genotype. Humans. Intellectual Disability / diagnosis. Intellectual Disability / genetics. Mutation / genetics. Phenotype

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  • (PMID = 16650978.001).
  • [ISSN] 0959-437X
  • [Journal-full-title] Current opinion in genetics & development
  • [ISO-abbreviation] Curr. Opin. Genet. Dev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / Transcription Factors
  • [Number-of-references] 41
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90. Russ AJ, Weber SM, Rettammel RJ, Mahvi DM, Rikkers LF, Cho CS: Impact of selection bias on the utilization of adjuvant therapy for pancreas adenocarcinoma. Ann Surg Oncol; 2010 Feb;17(2):371-6
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  • [Title] Impact of selection bias on the utilization of adjuvant therapy for pancreas adenocarcinoma.
  • BACKGROUND: Improved outcomes have been associated with the use of adjuvant therapy after resection of pancreas adenocarcinoma.
  • METHODS: A prospectively maintained database was reviewed to identify patients who underwent potentially curative resection of histologically confirmed pancreas adenocarcinoma at our institution from January 1996 to May 2007.
  • This selective utilization of postoperative therapy for patients with adverse oncological characteristics is likely to bias any retrospective analysis attempting to measure the efficacy of adjuvant treatment for pancreas adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / therapy. Antineoplastic Agents / therapeutic use. Pancreatic Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Pancreatectomy. Prospective Studies. Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies. Risk Factors. Selection Bias. Survival Rate. Treatment Outcome

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  • (PMID = 19851808.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / T32 CA090217
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Other-IDs] NLM/ NIHMS782325; NLM/ PMC4859782
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91. Oberholzer J, Tzvetanov I, Mele A, Benedetti E: Laparoscopic and robotic donor pancreatectomy for living donor pancreas and pancreas-kidney transplantation. J Hepatobiliary Pancreat Sci; 2010 Mar;17(2):97-100
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  • [Title] Laparoscopic and robotic donor pancreatectomy for living donor pancreas and pancreas-kidney transplantation.
  • Pancreas transplantation is a widely accepted procedure that can efficiently restore euglycemia and prevent progression of complications.
  • Living donor pancreas transplant was introduced at the University of Minnesota in 1979.
  • The only case reported worldwide of robotic distal pancreatectomy and nephrectomy for living donor pancreas-kidney transplantation was successfully performed by our team in 2006 at the University of Illinois at Chicago and proved as a promising technique.


92. Azzi J, Geara AS, El-Sayegh S, Abdi R: Immunological aspects of pancreatic islet cell transplantation. Expert Rev Clin Immunol; 2010 Jan;6(1):111-24
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  • [Title] Immunological aspects of pancreatic islet cell transplantation.
  • Whole-pancreas and islet cell transplantation seem to provide a potential solution by restoring the normal physiology of glucose-insulin homeostasis.
  • Although islet transplantation is less invasive than whole-pancreas transplantation, the insulin-free state after islet transplantation remained low (10%) at 5 years after surgery.

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  • (PMID = 20383895.001).
  • [ISSN] 1744-666X
  • [Journal-full-title] Expert review of clinical immunology
  • [ISO-abbreviation] Expert Rev Clin Immunol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; 0 / Inflammation Mediators
  • [Number-of-references] 167
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93. Noguchi H, Matsumoto S: Islet transplantation at the Diabetes Research Institute Japan. J Hepatobiliary Pancreat Surg; 2008;15(3):278-83
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  • It includes an in-situ cooling system for pancreas procurement, pancreatic ductal protection, a modified two-layer (M-Kyoto /perfluorochemical [PFC]) method of pancreas preservation, and a new islet purification solution (Iodixanol-based solution).
  • Using this islet isolation method, we isolated islets from 19 human pancreata of non-heart-beating donors and transplanted 16 preparations into seven patients with type 1 diabetes between April 7, 2004 and November 18, 2005.
  • Establishment of this method enables us to make diabetic patients insulin-independent, using islets not only from two or three pancreata of non-heart-beating donors but also using islets from half a pancreas from a living donor.


94. Wolf A, Bernhardt J, Patrzyk M, Heidecke CD: The value of endoscopic diagnosis and the treatment of pancreas injuries following blunt abdominal trauma. Surg Endosc; 2005 May;19(5):665-9
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  • [Title] The value of endoscopic diagnosis and the treatment of pancreas injuries following blunt abdominal trauma.
  • BACKGROUND: Injuries to the pancreas following blunt abdominal trauma are rare due to its protected retroperitoneal position.
  • Many pancreatic lesions remain unnoticed at first and only become apparent when complications arise or during treatment of other injuries.
  • METHODS: Using medical records over the past 5 years, we investigated when and in what circumstances endoscopic retrograde cholangiopancreaticography (ERCP) was used in the diagnosis and treatment of pancreas injuries after blunt abdominal trauma.
  • RESULTS: An ERCP was performed on a total of five patients with suspected injuries to the pancreas after blunt abdominal trauma.
  • No duct participation could be determined in three of the patients with a first degree pancreatic lesion.
  • Because of the nature of her injuries, pancreatic left resection with splenectomy was necessary.
  • After the operation, a pancreatic fistula diagnosed.
  • CONCLUSION: The major advantage of the prompt retrograde discription of the pancreatobiliary system after an accident in which pancreas involvement is suspected is the more precise assessment of the extent of the injuries.
  • [MeSH-major] Abdominal Injuries / diagnosis. Cholangiopancreatography, Endoscopic Retrograde. Pancreas / injuries. Wounds, Nonpenetrating / diagnosis
  • [MeSH-minor] Accidents, Traffic. Adult. Algorithms. Ampulla of Vater / injuries. Ampulla of Vater / surgery. Amylases / blood. Animals. Case Management. Contusions / diagnosis. Contusions / etiology. Drainage. Horses. Humans. Lipase / blood. Male. Middle Aged. Pancreatic Ducts / injuries. Pancreatic Ducts / surgery. Pancreatic Fistula / diagnosis. Pancreatic Fistula / etiology. Pancreatic Fistula / surgery. Pancreatitis / diagnosis. Pancreatitis / etiology. Pancreatitis / surgery. Retrospective Studies. Stents. Tomography, X-Ray Computed. Trauma Severity Indices. Ultrasonography

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  • (PMID = 15759197.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Case Reports; Evaluation Studies; Journal Article
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95. Zaret KS, Grompe M: Generation and regeneration of cells of the liver and pancreas. Science; 2008 Dec 5;322(5907):1490-4
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  • [Title] Generation and regeneration of cells of the liver and pancreas.
  • Liver and pancreas progenitors develop from endoderm cells in the embryonic foregut.
  • Shortly after their specification, liver and pancreas progenitors rapidly acquire markedly different cellular functions and regenerative capacities.
  • Interest in the development and regeneration of the organs has been fueled by the intense need for hepatocytes and pancreatic beta cells in the therapeutic treatment of liver failure and type I diabetes.
  • Studies in diverse model organisms have revealed evolutionarily conserved inductive signals and transcription factor networks that elicit the differentiation of liver and pancreatic cells and provide guidance for how to promote hepatocyte and beta cell differentiation from diverse stem and progenitor cell types.

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  • (PMID = 19056973.001).
  • [ISSN] 1095-9203
  • [Journal-full-title] Science (New York, N.Y.)
  • [ISO-abbreviation] Science
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / DK051592-11; None / None / / P30 CA006927-46; United States / NIDDK NIH HHS / DK / U01 DK072503-04; United States / NIDDK NIH HHS / DK / U01 DK072503; United States / NIDDK NIH HHS / DK / U01 DK072477-04; United States / NIDDK NIH HHS / DK / DK072477-04; United States / NIGMS NIH HHS / GM / R01 GM036477-21; United States / NIDDK NIH HHS / DK / R01 DK051592; United States / NCI NIH HHS / CA / P30CA06927; United States / NIGMS NIH HHS / GM / GM036477-21; United States / NIGMS NIH HHS / GM / R01 GM036477; United States / NIDDK NIH HHS / DK / DK072503-04; United States / NIDDK NIH HHS / DK / U01 DK072477; United States / NCI NIH HHS / CA / P30 CA006927-46; United States / NIGMS NIH HHS / GM / R37 GM036477; United States / NIDDK NIH HHS / DK / R01 DK051592-11; United States / NCI NIH HHS / CA / P30 CA006927; United States / NIGMS NIH HHS / GM / R37 GM36477; United States / NIDDK NIH HHS / DK / R0I DK05192
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Transcription Factors
  • [Number-of-references] 81
  • [Other-IDs] NLM/ NIHMS90121; NLM/ PMC2641009
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96. Nakajima Y, Kakizaki S, Kanda D, Shimada Y, Sohara N, Sato K, Takagi H, Mori M, Watanabe H: Pancreatic and gastric metastases of leiomyosarcoma arising in the left leg. Int J Clin Oncol; 2005 Oct;10(5):342-7
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  • [Title] Pancreatic and gastric metastases of leiomyosarcoma arising in the left leg.
  • Pancreatic or gastric metastases from other primary malignancies are rare, especially from leiomyosarcoma.
  • We report a case of leiomyosarcoma in the left lower leg with metastases to the pancreas and stomach.
  • On admission, endoscopic examination and computed tomography were performed for a routine checkup to exclude esophageal varices and liver tumor.
  • Although the patient had no specific symptoms, multiple gastric and pancreatic metastases were identified by endoscopy and computed tomography, respectively.
  • In general, metastases to the pancreas and stomach are rare.
  • We discuss the clinical and diagnostic findings of pancreatic and gastric metastases by reviewing previously reported cases.
  • [MeSH-major] Leg. Leiomyosarcoma / secondary. Muscle Neoplasms / pathology. Pancreatic Neoplasms / secondary. Stomach Neoplasms / secondary

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  • (PMID = 16247662.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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97. Fujii T, Ishikawa T, Kanazumi N, Sugimoto H, Nomoto S, Inoue S, Nagasaka T, Takeda S, Nakao A: Analysis of clinicopathological features and predictors of malignancy in intraductal papillary mucinous neoplasms of the pancreas. Hepatogastroenterology; 2007 Jan-Feb;54(73):272-7
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  • [Title] Analysis of clinicopathological features and predictors of malignancy in intraductal papillary mucinous neoplasms of the pancreas.
  • We reviewed our experience in order to elucidate predictors of tumor malignancy, invasiveness, and outcome.
  • RESULTS: The histological diagnosis was adenoma in 40, borderline in 1, carcinoma in situ (CIS) in 7, and invasive carcinoma in 9 patients.
  • Patients with invasive carcinomas had significantly shorter survival rates than patients with benign IPMNs or CIS (p < 0.0001).
  • CONCLUSIONS: IPMNs generally grow slowly, but have a malignant potential that warrants radical surgical treatment when the tumor component invades the parenchyma.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Papillary / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoma in Situ / pathology. Carcinoma in Situ / surgery. Female. Humans. Male. Middle Aged. Multivariate Analysis. Neoplasm Invasiveness. Pancreaticoduodenectomy. Retrospective Studies

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  • (PMID = 17419275.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Number-of-references] 32
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98. Scott WE 3rd, Weegman BP, Ferrer-Fabrega J, Stein SA, Anazawa T, Kirchner VA, Rizzari MD, Stone J, Matsumoto S, Hammer BE, Balamurugan AN, Kidder LS, Suszynski TM, Avgoustiniatos ES, Stone SG, Tempelman LA, Sutherland DE, Hering BJ, Papas KK: Pancreas oxygen persufflation increases ATP levels as shown by nuclear magnetic resonance. Transplant Proc; 2010 Jul-Aug;42(6):2011-5
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  • [Title] Pancreas oxygen persufflation increases ATP levels as shown by nuclear magnetic resonance.
  • Due to a shortage of suitable human pancreata, high cost, and the large dose of islets presently required for long-term diabetes reversal; it is important to maximize viable islet yield.
  • Traditional methods of pancreas preservation have been identified as suboptimal due to insufficient oxygenation.
  • METHODS: Human pancreata were obtained from brain-dead donors.
  • Porcine pancreata were procured by en bloc viscerectomy from heparinized donation after cardiac death donors and were either preserved by either two-layer method (TLM) or PSF.
  • RESULTS: Human and porcine pancreata can be effectively preserved by PSF.
  • MRI showed that pancreatic tissue was homogeneously filled with gas.
  • TLM can effectively raise ATP:P(i) levels in rat pancreata but not in larger porcine pancreata.
  • When human or porcine organs were preserved by PSF, ATP:P(i) was elevated to levels similar to those observed in rat pancreata.
  • CONCLUSION: The methods developed for human and porcine pancreas PSF homogeneously deliver oxygen throughout the organ.

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
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  • (PMID = 20692395.001).
  • [ISSN] 1873-2623
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R43 DK070400; United States / NIDDK NIH HHS / DK / R44 DK070400; United States / NIDDK NIH HHS / DK / R43 DK070400-02; United States / NCRR NIH HHS / RR / U42 RR016598; United States / NIDDK NIH HHS / DK / DK070400-03A1; United States / NIDDK NIH HHS / DK / R44 DK070400-03A1; United States / NIDDK NIH HHS / DK / DK070400-02S1; United States / NIDDK NIH HHS / DK / R43 DK070400-02S1; United States / NIDDK NIH HHS / DK / DK070400-02; United States / NIDDK NIH HHS / DK / R43 DK070400-01A1; United States / NIDDK NIH HHS / DK / DK070400-01A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organ Preservation Solutions
  • [Other-IDs] NLM/ NIHMS223789; NLM/ PMC2947552
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99. Leonard D, Baulieux J, Rode A, Garbit V, De La Roche E, Ducerf C, Mabrut JY: Multiple synchronous serous cystadenomas of the pancreas: uncommon CT and MRI findings. J Hepatobiliary Pancreat Surg; 2007;14(6):600-3
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  • [Title] Multiple synchronous serous cystadenomas of the pancreas: uncommon CT and MRI findings.
  • Serous cystadenomas (SCAs) of the pancreas are benign cystic tumors.
  • This attitude is mostly defendable for lesions of the pancreas head or multiple lesions distributed throughout the entire pancreas, as their surgical resection is still associated with significant morbidity.
  • Thus, correct diagnosis is essential, and this relies on radiological and biological characteristics.
  • We present a case of huge (>10 cm), multiple asymptomatic SCAs, not associated with von Hippel-Lindau disease, involving the entire pancreas.
  • Tumor markers were within normal ranges.
  • [MeSH-major] Cystadenoma, Serous / diagnosis. Neoplasms, Multiple Primary / diagnosis. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 18040629.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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100. Zhou J, Zhou S, Tang J, Zhang K, Guang L, Huang Y, Xu Y, Ying Y, Zhang L, Li D: Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats. Eur J Pharmacol; 2009 Mar 15;606(1-3):262-8
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  • The present study was designed to evaluate the protective effects of berberine against beta cell damage and antioxidant of pancreas in diabetic rats.
  • After 16 weeks treatment, serum insulin level, insulin expression in pancreas, and malonaldehyde content, superoxide dismutase activity in pancreatic homogenate were assayed.
  • Pancreas was examined by hematoxylin/eosin staining and transmission electron microscope.
  • Pancreas to body weight ratio, insulin level, insulin sensitivity index, malonaldehyde content and superoxide dismutase activity were altered in diabetic rats, and were near control levels treated with 150, 300 mg/kg berberine.
  • The pancreatic islet area atrophied and secretory granules of beta cells decreased in diabetic rats.
  • Slight pathological changes existed in beta cells of 150, 300 mg/kg berberine-treated diabetic pancreas.

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  • Hazardous Substances Data Bank. STREPTOZOTOCIN .
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  • (PMID = 19374872.001).
  • [ISSN] 1879-0712
  • [Journal-full-title] European journal of pharmacology
  • [ISO-abbreviation] Eur. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Dietary Carbohydrates; 0 / Dietary Fats; 0 / Insulin; 0I8Y3P32UF / Berberine; 4Y8F71G49Q / Malondialdehyde; 5W494URQ81 / Streptozocin; EC 1.15.1.1 / Superoxide Dismutase; TDQ283MPCW / Eosine Yellowish-(YS); YKM8PY2Z55 / Hematoxylin
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