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[Title] Experimental study of the safety of pancreas cryosurgery: the comparison of 2 different techniques of cryosurgery.

OBJECTIVES: To test the feasibility of cryosurgery for pancreatic carcinoma and to observe the consequence of cryosurgery by 2 different techniques.

METHODS: Twelve healthy pigs underwent laparotomy, during which, chop amputation of common bile duct and duodenum were performed, meanwhile other intra-abdominal organs with the pancreas were isolated.

Two different techniques of cryosurgery were performed on the pancreas.

All animals in group B survived during the observation, in which only a transient increment and a gradual correction of pancreatic amylase level were recorded.

Small pancreatic pseudocyst occurred in 1 case.

CONCLUSIONS: Mild hypothermic cryosurgery with liquid nitrogen superficial refrigeration might lead to pancreatic injury and induce acute pancreatitis, yet deep hypothermic cryosurgery with adequate time showed a promising effect in destroying pancreatic tissue and preventing acute pancreatitis.

[MeSH-major] Cryosurgery / methods. Pancreas / surgery

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(PMID = 19952969.001).

[ISSN] 1536-4828

[Journal-full-title] Pancreas

[ISO-abbreviation] Pancreas

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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[Title] B1 cells promote pancreas infiltration by autoreactive T cells.

The entry of autoreactive T cells into the pancreas is a critical checkpoint in the development of autoimmune diabetes.

In transgenic mice with islet-specific T cells, but no B cells, T cells are primed in the pancreatic lymph node but fail to enter the pancreas.

Reconstitution of the B1 cell population by adoptive transfer permits extensive T cell pancreas infiltration.

Reconstituted B1 cells traffic to the pancreas and modify expression of adhesion molecules on pancreatic vasculature, notably VCAM-1.

Despite substantial pancreas infiltration, islet destruction is minimal unless regulatory T cells are depleted.

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(PMID = 20675587.001).

[ISSN] 1550-6606

[Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)

[ISO-abbreviation] J. Immunol.

[Language] eng

[Grant] United Kingdom / Wellcome Trust / / 085896; United Kingdom / Medical Research Council / / G120/854; United Kingdom / Medical Research Council / / G0802382; United Kingdom / Medical Research Council / / ; United Kingdom / Wellcome Trust / /

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Vascular Cell Adhesion Molecule-1; 9006-59-1 / Ovalbumin

[Other-IDs] NLM/ EMS58025; NLM/ PMC3983558

   

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Intraductal papillary mucinous neoplasms (IPMN) of the pancreas are of increasing interest in the field of pancreatic surgery ever since their first description as an individual pancreatic tumor entity in 1982.

Invasive IPMN forms (carcinoma in situ and invasive carcinoma) and in particular noninvasive IPMNs (adenoma and borderline tumors) reveal significantly better survival rates than ductal adenocarcinoma of the pancreas.

[MeSH-major] Adenocarcinoma, Mucinous / surgery. Carcinoma, Pancreatic Ductal / surgery. Carcinoma, Papillary / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery

[MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / mortality. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Carcinoma in Situ / diagnosis. Carcinoma in Situ / mortality. Carcinoma in Situ / pathology. Carcinoma in Situ / surgery. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neoplasm Staging. Pancreas / pathology. Prognosis. Radiography, Dual-Energy Scanned Projection. Survival Rate. Tomography, Spiral Computed

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(PMID = 19082569.001).

[ISSN] 1433-0385

[Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen

[ISO-abbreviation] Chirurg

[Language] ger

[Publication-type] Comparative Study; English Abstract; Journal Article; Review

[Publication-country] Germany

[Number-of-references] 50

   

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[Title] Surgical management of intraductal papillary mucinous neoplasm (IPMN) of the pancreas.

Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is characterized by papillary growths within the pancreatic ductal system that are at risk for undergoing malignant transformation.

When operation is indicated, targeted pancreatic resection with frozen-section analysis of margins is recommended.

Survival following pancreatic resection for noninvasive IPMN is excellent.

The risk of recurrence following pancreatic resection for invasive IPMN is significant.

Surveillance is warranted both for patients subjected to pancreatic resection and for those under observation with side branch IPMN.

Much is yet to be learned regarding this neoplasm, and surgical management remains in evolution.

[MeSH-major] Adenoma / surgery. Carcinoma in Situ / surgery. Carcinoma, Pancreatic Ductal / surgery. Pancreatectomy. Pancreatic Neoplasms / surgery. Precancerous Conditions / surgery

[MeSH-minor] Carcinoma, Papillary / surgery. Diagnostic Imaging. Dilatation, Pathologic. Humans. Pancreatic Ducts / pathology. Pancreaticoduodenectomy

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(PMID = 17968632.001).

[ISSN] 1091-255X

[Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

[ISO-abbreviation] J. Gastrointest. Surg.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

[Number-of-references] 24

   

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[Title] Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion.

BETA2 plays an important role in the development of the pancreas and the nervous system.

Using microarray technology, we identified neuronatin (Nnat) as differentially expressed between wild-type (WT) and knockout (KO) pancreatic RNA from embryonic day 14 (e14.5).

Northern blot and in situ hybridization analysis of WT and KO samples confirmed the downregulation of Nnat in pancreas of mutant BETA2 embryos.

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(PMID = 15793245.001).

[ISSN] 0012-1797

[Journal-full-title] Diabetes

[ISO-abbreviation] Diabetes

[Language] ENG

[Grant] United States / NICHD NIH HHS / HD / R01 HD017379; United States / NICHD NIH HHS / HD / R37 HD017379; United States / NICHD NIH HHS / HD / HD-17379

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.

[Publication-country] United States

[Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / DNA-Binding Proteins; 0 / Insulin; 0 / Membrane Proteins; 0 / Nerve Tissue Proteins; 0 / Neurod1 protein, mouse; 0 / Nnat protein, mouse; 0 / RNA, Small Interfering; 0 / Trans-Activators; IY9XDZ35W2 / Glucose

[Other-IDs] NLM/ NIHMS2527; NLM/ PMC1197706

   

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[Title] [Pancreas. Part I: congenital changes, acute and chronic pancreatitis].

[Transliterated title] Pankreas. Teil I: Angeborene Veränderungen, akute und chronische Pankreatitis.

The pancreas develops from ventral and the dorsal buds, which undergo fusion.

Failure to fuse results in pancreas divisum, which is defined by separate pancreatic ductal systems draining into the duodenum.

Risk of developing pancreatitis is increased in pancreas divisum because of insufficient drainage.

MR cholangiopancreatography (MRCP) is the technique of choice for detecting pancreas divisum non-invasively.

Annular pancreas is the result of incomplete rotation of the pancreatic bud around the duodenum with the persistence of parenchyma or a fibrous band encircling (and sometimes stenosing) the duodenum.

Chronic pancreatitis results in relentless and irreversible loss of exocrine (and sometimes endocrine) function of the pancreas.

Inflammatory pseudotumor in chronic pancreatitis and groove pancreatitis are difficult to differentiate from pancreatic cancer.

In these cases, multiple imaging methods such as MDCT, MRI and endosonography including biopsy may be used to make a diagnosis.

[MeSH-major] Cholangiopancreatography, Magnetic Resonance / methods. Image Enhancement / methods. Pancreatitis / congenital. Pancreatitis / diagnosis. Tomography, X-Ray Computed / methods

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(PMID = 16496105.001).

[ISSN] 0033-832X

[Journal-full-title] Der Radiologe

[ISO-abbreviation] Radiologe

[Language] ger

[Publication-type] English Abstract; Journal Article; Review

[Publication-country] Germany

[Chemical-registry-number] 0 / Contrast Media

[Number-of-references] 33

   

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[Title] Trans-hepatic technique and intraluminal Pulsed Dose Rate (PDR-BT) brachytherapy in treatment of locally advanced bile duct and pancreas cancer.

PURPOSE: To assess the feasibility of intraluminal palliative Pulsed Dose Rate (PDR-BT) brachytherapy in the treatment of locally advanced bile duct and pancreas cancer.

MATERIAL AND METHODS: Forty-eight patients with advanced bile duct or pancreas cancer, disqualified from surgery or radical external beam radiation therapy (EBRT), were treated with trans-hepatic technique and intraluminal PDR-BT: 29 patients with bile duct cancer and 19 - pancreas cancer.

Target volume encompassed tumor visualized at cholangiography with one or two cm margin measured proximally and distally.

In 19 out of 29 (65.5%) of bile duct cancer cases and in 10 out of 19 (52.6%) of pancreas cancer patients clinical improvement (decrease of jaundice) was noted in first control after 4 weeks.

Median overall survival time (OS) for bile ducts cancer patients was 11.2 months and for pancreas cancer patients - 5.2 months.

2. In most cases a satisfied palliative effect was achieved, however it was more apparent in bile duct cancer patients then in pancreas cancer patients.

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(PMID = 27795719.001).

[ISSN] 1689-832X

[Journal-full-title] Journal of contemporary brachytherapy

[ISO-abbreviation] J Contemp Brachytherapy

[Language] eng

[Publication-type] Journal Article

[Publication-country] Poland

[Keywords] NOTNLM ; PDR brachytherapy / bile duct cancer / pancreas cancer

   

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[Title] Family history of diabetes as a new determinant of insulin sensitivity and secretion in patients who have undergone a simultaneous pancreas-kidney transplant.

OBJECTIVES: We used homeostasis model assessment to investigate insulin sensitivity and secretion after a simultaneous pancreas-kidney transplant or kidney transplant alone.

MATERIALS AND METHODS: Factors (eg, age, sex, race, delayed kidney allograft function) were correlated with homeostasis model assessment of beta-cell function and homeostasis model assessment of insulin sensitivity values after simultaneous pancreas-kidney transplant (n=89) or kidney transplant alone (n=68), and the results were compared with those in healthy subjects (n=49).

RESULTS: Homeostasis model assessment of beta-cell function values were similar in patients who underwent kidney transplant alone or a simultaneous pancreas-kidney transplant, and were higher than homeostasis model assessment of beta cell function values in healthy subjects.

The homeostasis model assessment of insulin sensitivity showed intermediate values for patients who underwent a simultaneous pancreas-kidney transplant and correlated with prednisone dosages (in those who underwent kidney transplant alone) and tacrolimus levels (in patients who underwent a simultaneous pancreas-kidney transplant).

Homeostasis model assessment of beta-cell function values correlated with prednisone dosages in both groups and with tacrolimus levels in only those who underwent a simultaneous pancreas-kidney transplant.

A family history of diabetes in subjects who underwent a simultaneous pancreas-kidney transplant correlated with homeostasis model assessment of beta-cell function results and homeostasis model assessment of insulin sensitivity results.

A family history of diabetes was linked with higher values of insulin secretion and lower insulin sensitivity in patients who underwent a simultaneous pancreas-kidney transplant.

[MeSH-major] Diabetes Mellitus / genetics. Insulin / secretion. Insulin Resistance / physiology. Kidney Transplantation / physiology. Pancreas Transplantation / physiology. Pedigree

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(PMID = 20199368.001).

[ISSN] 2146-8427

[Journal-full-title] Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

[ISO-abbreviation] Exp Clin Transplant

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Turkey

[Chemical-registry-number] 0 / Blood Glucose; 0 / C-Peptide; 0 / Immunosuppressive Agents; 0 / Insulin; VB0R961HZT / Prednisone; WM0HAQ4WNM / Tacrolimus

   

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During APRV with SB blood flow (ml g(-1) min(-1)) was 0.91+/-0.26 (hepatic arterial), 0.29+/-0.05 (stomach), 0.64+/-0.08 (duodenum), 0.62+/-0.10 (jejunum), 0.53+/-0.07 (ileum), 0.53+/-0.07 (colon), 0.46+/-0.09 (pancreas) and 3.59+/-0.55 (spleen).

During APRV without SB applying high P(aw) it decreased to 0.13+/-0.01 (stomach), 0.37+/-0.03 (duodenum), 0.29+/-0.03 (jejunum), 0.31+/-0.05 (ileum), 0.32+/-0.03 (colon) and 0.23+/-0.04 (pancreas) p<0.01, respectively.

During APRV without SB applying same Paw limits it decreased to 0.18+/-0.03 (stomach, p<0.01), 0.47+/-0.06 (duodenum, p<0.05), 0.38+/-0.05 (jejunum, p<0.01), 0.36+/-0.03 (ileum, p<0.05), 0.39+/-0.05 (colon, p<0.05), and 0.27+/-0.04 (pancreas, p<0.01).

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[CommentIn] Intensive Care Med. 2008 Mar;34(3):397-9 [18087690.001]

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(PMID = 18087691.001).

[ISSN] 0342-4642

[Journal-full-title] Intensive care medicine

[ISO-abbreviation] Intensive Care Med

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 2UMI9U37CP / Oleic Acid; S88TT14065 / Oxygen

   

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OBJECTIVE: We investigated the long-term outcome of autoimmune pancreatitis (AIP) including morphological changes in the pancreas, pancreatic duct, biliary tract, pancreatic function, and changes in the clinical manifestations after oral prednisolone (PSL) therapy.

The morphological findings consisted of pancreatic enlargement (n=12), an irregularly narrowed main pancreatic duct (n=12), and bile duct stricture (n=10), and salivary gland swelling was observed in six patients.

The enlargement of the pancreas and the irregularly narrowed main pancreatic duct improved to almost normal.

Pancreatic atrophy developed in four of them (4/12, 33%), but no pancreatic calcification was observed in any of the patients.

There was no recurrence of enlargement of the pancreas or irregularly narrowed main pancreatic duct after PSL therapy, but the bile duct stricture recurred in one case, and in three cases there was a relapse of salivary gland swelling that required a temporary increase in PSL dose during tapering.

No deterioration of pancreatic exocrine function was detected in any of the patients.

A malignant tumor was diagnosed in two patients during PSL therapy: early gastric cancer in one and rectal cancer in the other.

CONCLUSIONS: AIP treated with PSL has a favorable long-term outcome based on the morphological findings and assessments of pancreatic function.

[MeSH-minor] Administration, Oral. Aged. Biliary Tract / pathology. Cholangiopancreatography, Endoscopic Retrograde. Female. Humans. Immunoglobulin G / blood. Male. Middle Aged. Pancreatic Ducts / pathology. Pancreatic Function Tests. Salivary Glands / pathology. Sjogren's Syndrome / diagnosis. Tomography, X-Ray Computed

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(PMID = 16702740.001).

[ISSN] 1349-7235

[Journal-full-title] Internal medicine (Tokyo, Japan)

[ISO-abbreviation] Intern. Med.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Japan

[Chemical-registry-number] 0 / Glucocorticoids; 0 / Immunoglobulin G; 9PHQ9Y1OLM / Prednisolone

   

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[Title] Preventive and therapeutic effects of the protease inhibitor camostat on pancreatic fibrosis and atrophy in CCK-1 receptor-deficient rats.

OBJECTIVES: Recent studies have demonstrated that synthetic protease inhibitors could ameliorate the progression of pancreatic fibrosis in some animal models.

Since oral administration of protease inhibitors increases the plasma cholecystokinin (CCK) levels and causes hypertrophy of the pancreas in rats, there is a possibility that the protease inhibitor inhibits fibrosis in the pancreas via endogenous CCK release.

We examined the effects of camostat, a synthetic protease inhibitor, on histopathologic changes in Otsuka Long-Evans Tokushima Fatty (OLETF) rat that has genetically no expression of CCK-1 receptor and displays inflammation and degeneration of the pancreas.

RESULTS: Pancreatic wet weight and pancreatic contents of protein, DNA, amylase, lipase, and trypsin in camostat-treated rats were significantly higher than those in the untreated control rats.

Immunohistochemical studies of the pancreas showed that expressions of interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, and alpha-smooth muscle actin in camostat-treated rats were greatly suppressed compared with those in the untreated control rats.

Atrophy and fibrosis in the pancreas observed in the untreated control rats were not found in camostat-fed rats.

CONCLUSION: The results of the present study suggest that camostat greatly inhibits pancreatic inflammation and prevents and reverses fibrosis and atrophy of the pancreas in the genetically obese and CCK-1 receptor-deficient OLETF rats.

[MeSH-minor] Actins / metabolism. Amylases / metabolism. Animals. Atrophy. Eating. Fibrosis. Interleukin-6 / metabolism. Lipase / metabolism. Male. Obesity / complications. Organ Size. Pancreas / enzymology. Pancreas / pathology. Rats. Rats, Inbred OLETF. Transforming Growth Factor beta / metabolism. Trypsin / metabolism. Tumor Necrosis Factor-alpha / metabolism

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(PMID = 15632700.001).

[ISSN] 1536-4828

[Journal-full-title] Pancreas

[ISO-abbreviation] Pancreas

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Actins; 0 / Interleukin-6; 0 / Protease Inhibitors; 0 / Receptor, Cholecystokinin A; 0 / Transforming Growth Factor beta; 0 / Tumor Necrosis Factor-alpha; 0FD207WKDU / camostat; 4V7M9137X9 / Gabexate; EC 3.1.1.3 / Lipase; EC 3.2.1.- / Amylases; EC 3.4.21.4 / Trypsin

   

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[Title] Collagenase penetrates human pancreatic islets following standard intraductal administration.

The aim of this study was to characterize collagenase distribution in relation to islets in infused human pancreases.

METHODS: : Human pancreases were retrieved from multiorgan donors with appropriate consent.

RESULTS: : Collagenase labeling was widespread throughout the pancreas, associated with collagen VI, and adjacent to CK19-labeled ducts.

Intraislet collagenase was observed in 70%+/-3% of islets in the pancreatic tail, compared with 58%+/-2% and 53%+/-2% of islets in the body and neck, respectively (P<0.05 tail vs. neck), and was more prevalent in islets with diameters more than 150 microm (98%+/-1% of islets >150 microm vs. 52%+/-2% of islets <150 microm, P<0.05).

There was no difference in intraislet collagenase labeling between perfused and syringe-loaded pancreases.

[MeSH-minor] Drug Administration Routes. Humans. Organ Preservation Solutions. Pancreas / anatomy & histology. Pancreas / enzymology. Pancreas, Exocrine / enzymology. Pancreatic Ducts / metabolism

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(PMID = 18852654.001).

[ISSN] 1534-6080

[Journal-full-title] Transplantation

[ISO-abbreviation] Transplantation

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Organ Preservation Solutions; EC 3.4.24.- / Collagenases

   

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[Title] Preservation of pancreatic tissue morphology, viability and energy metabolism during extended cold storage in two-layer oxygenated University of Wisconsin/perfluorocarbon solution.

BACKGROUND: In contrast to the relative scarcity of donor kidneys and hearts, the potential supply of deceased donor pancreata is exceeding the demand.

However, this organ surplus is not being fully realized because, in current transplantation practice, the duration of pancreas storage before transplantation is limited to 8-10 hours due to the extreme vulnerability of pancreatic tissue to anaerobic damage caused by preservation.

OBJECTIVES: To reduce cold ischemic injury in order to increase the utilization of donor pancreases in Israel for whole-organ and cell transplantation.

METHODS: We evaluated a novel two-layer preservation oxygenated cold storage method that uses perfluorocarbon to continuously supply oxygen to the pancreas during preservation in conventional University of Wisconsin solution.

RESULTS: Pancreatic tissue morphology, viability and adenosine-triphosphate content were serially examined during preservation of the pig pancreas for 24 hours either by a two-layer or by conventional simple cold storage.

CONCLUSIONS: The UW/PFC two-layer preservation method allowed tissue ATP synthesis and amelioration of cold ischemic tissue damage during extended 24 hour pancreas preservation.

This method could be implemented in clinical practice to maximize utilization of pancreata for whole-organ and islet transplantation as well as for pancreas sharing with remote centers.

[MeSH-major] Cryopreservation / methods. Fluorocarbons. Organ Preservation / methods. Pancreas

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(PMID = 18548980.001).

[ISSN] 1565-1088

[Journal-full-title] The Israel Medical Association journal : IMAJ

[ISO-abbreviation] Isr. Med. Assoc. J.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Israel

[Chemical-registry-number] 0 / Fluorocarbons; 0 / Organ Preservation Solutions; 8L70Q75FXE / Adenosine Triphosphate

   

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[Title] Metabolic assessment after simultaneous pancreas-kidney transplantation.

Simultaneous pancreas-kidney (SPK) transplantation has become a standard therapy for patients with type 1 diabetes and end-stage renal disease.

PATIENTS AND METHODS: We analyzed 205 patients enrolled in the Euro-SPK001 study for fasting blood glucose, fasting C peptide, glycated hemoglobin (HbA(1c)), blood lipids (total cholesterol and triglycerides), and pancreatic enzymes at regular intervals during the study.

[MeSH-major] Hemoglobin A, Glycosylated / analysis. Kidney Transplantation / physiology. Pancreas Transplantation / physiology

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(PMID = 16182831.001).

[ISSN] 0041-1345

[Journal-full-title] Transplantation proceedings

[ISO-abbreviation] Transplant. Proc.

[Language] eng

[Publication-type] Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Blood Glucose; 0 / C-Peptide; 0 / Hemoglobin A, Glycosylated; 0 / Immunosuppressive Agents; 0 / Lipids; EC 3.2.1.- / Amylases

   

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[Title] Grp78 heterozygosity regulates chaperone balance in exocrine pancreas with differential response to cerulein-induced acute pancreatitis.

The endoplasmic reticulum (ER) is abundant in the acinar cells of the exocrine pancreas.

Exocrine pancreata of RD-fed Grp78(+/-) mice in an outbred C57BL/6 × 129/sv genetic background exhibited ER lumen dilation, a reduction in chaperones calnexin (CNX) and calreticulin (CRT), and exacerbated pancreatitis associated with high CHOP induction.

Thus, in exocrine pancreata, Grp78 heterozygosity regulates ER chaperone balance, in dietary- and genetic background-dependent manners, and improved ER protein folding capacity might be protective against pancreatitis.

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(PMID = 20971738.001).

[ISSN] 1525-2191

[Journal-full-title] The American journal of pathology

[ISO-abbreviation] Am. J. Pathol.

[Language] ENG

[Grant] United States / NIAAA NIH HHS / AA / AA16010; United States / NIAAA NIH HHS / AA / AA11999; United States / NIDDK NIH HHS / DK / DK070582; United States / NIAAA NIH HHS / AA / R21 AA016010; United States / NCI NIH HHS / CA / R01 CA027607; United States / NIDDK NIH HHS / DK / R21 DK070582; United States / NIDDK NIH HHS / DK / P30 DK048522; United States / NCI NIH HHS / CA / CA027607; United States / NIAAA NIH HHS / AA / P50 AA011999; United States / NIDDK NIH HHS / DK / DK048522

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

[Publication-country] United States

[Chemical-registry-number] 0 / Dietary Fats; 0 / Gastrointestinal Agents; 0 / Heat-Shock Proteins; 0 / Molecular Chaperones; 0 / molecular chaperone GRP78; 888Y08971B / Ceruletide

[Other-IDs] NLM/ PMC2993313

   

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[Title] Pancreatogram findings for carcinoma in situ (CIS) of the pancreas seen on endoscopic retrograde cholangiopancreatography and postoperative pancreatography of resected specimens: can CIS be diagnosed preoperatively?

In addition, 7 of 79 invasive ductal carcinomata (IDC) of the pancreas were accompanied by CIS > or =2 cm long.

A total of 11 patients were reviewed here for pancreatographic findings for CIS of the pancreas.

METHODS: All resected pancreatobiliary materials were sliced serially at 5- to 8-mm intervals in a plane at right angles to the main pancreatic duct, referring to POP images.

CONCLUSIONS: I, N, G, and D are most important pancreatographic findings in ERCP and highly suggestive of CIS of the pancreas, so that whenever they are encountered, cytological and/or pathological examination of the pancreatic duct should be actively performed.

[MeSH-major] Carcinoma in Situ / radiography. Cholangiopancreatography, Endoscopic Retrograde. Pancreas / radiography. Pancreatic Neoplasms / radiography

[MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Incidental Findings. Male. Middle Aged. Pancreatic Ducts / radiography. Postoperative Care. Preoperative Care

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[Copyright] Copyright 2008 S. Karger AG, Basel.

(PMID = 18382100.001).

[ISSN] 1424-3911

[Journal-full-title] Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]

[ISO-abbreviation] Pancreatology

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Switzerland

   

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[Title] How to recognize a suitable pancreas donor: a Eurotransplant study of preprocurement factors.

INTRODUCTION: Because of the increasing demand for pancreas transplantation, more marginal donors are offered to Eurotransplant.

The aim of this study was to validate a donor quality score that would facilitate recognition of a suitable pancreas donor among all reported donors.

MATERIALS AND METHODS: We analyzed all 3180 consecutively reported pancreas donors for the period between January 1, 2002 and June 30, 2005 and determined the influence of the preprocurement pancreas suitability score (P-PASS) on the acceptance of a pancreas.

RESULTS: Multiple regression analysis using pancreas acceptance as an outcome variable identified P-PASS > or = 17 as a significant cutoff point (P < .001).

Pancreata from donors with P-PASS > or = 17 were three times more likely to be refused.

CONCLUSION: The donor score can help in screening for potential pancreas donors, where an ideal donor has a P-PASS < 17.

Our data demonstrate that consideration of a combination of preprocurement factors can help identify a suitable pancreas donor.

Therefore, we recommend that a pancreas donor score be calculated for each potential pancreas donor, and all donors with a P-PASS < 17 should be considered for pancreas donation.

[MeSH-major] Pancreas. Pancreas Transplantation / methods. Tissue Donors / statistics & numerical data. Tissue and Organ Procurement / methods

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(PMID = 18589086.001).

[ISSN] 0041-1345

[Journal-full-title] Transplantation proceedings

[ISO-abbreviation] Transplant. Proc.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / ABO Blood-Group System

   

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One way to achieve a constant normoglycemic state without hypoglycemic episodes is either whole pancreas transplantation, or transplantation of isolated islets of Langerhans.

Another approach to correct the beta-cell deficit is the stimulation of beta-cells in pancreas to regeneration.

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(PMID = 20196471.001).

[ISSN] 0006-9248

[Journal-full-title] Bratislavské lekárske listy

[ISO-abbreviation] Bratisl Lek Listy

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review

[Publication-country] Slovakia

[Number-of-references] 47

   

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[Title] MDCT of intraductal papillary mucinous neoplasm of the pancreas: evaluation of features predictive of invasive carcinoma.

OBJECTIVE: The purpose of our study was to evaluate factors predictive of the presence of invasive carcinoma associated with intraductal papillary mucinous neoplasm (IPMN) of the pancreas on MDCT.

MATERIALS AND METHODS: Preoperative MDCT of 36 consecutive patients (23 men, 13 women; mean age, 66.6 years) who had undergone surgical resection and had a pathologic diagnosis of IPMN were retrospectively assessed.

Type of ductal involvement, location, tumor size in branch duct type and combined type lesions, caliber of the main pancreatic duct, caliber of the common bile duct or common hepatic duct, and solid appearance of the lesion were assessed on CT and correlated with pathologic findings for invasive carcinoma.

With invasive carcinoma, the size of the tumor in branch duct type and combined type, and the caliber of the main pancreatic duct were significantly larger compared with the lesions without invasive carcinoma (4.7 +/- 1.7 cm vs 2.6 +/- 1.4 cm [p = 0.0007] and 9.3 +/- 5.5 mm vs 4.6 +/- 4.1 mm [p = 0.006], respectively).

[MeSH-major] Adenocarcinoma, Mucinous / radiography. Carcinoma, Pancreatic Ductal / radiography. Pancreatic Neoplasms / radiography. Tomography, X-Ray Computed / methods

[MeSH-minor] Adult. Aged. Aged, 80 and over. Contrast Media. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity

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(PMID = 16498096.001).

[ISSN] 0361-803X

[Journal-full-title] AJR. American journal of roentgenology

[ISO-abbreviation] AJR Am J Roentgenol

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Contrast Media

   

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The limited availability of cadaveric human donor pancreata as well as the incomplete success of the Edmonton protocol for human islet allografts fasten search for new sources of insulin the producing cells for substitution cell therapy of insulin-dependent diabetes mellitus (T1DM).

Starting from isolated neonatal porcine pancreatic islets (NPIs), we have obtained cell monolayers that were exposed to microencapsulated monolayered Sertoli cells (ESCs) for different time periods (7, 14, 21 days).

The insulin/c-kit positive cells might represent a new, still unknown functionally immature β-cell like element in the porcine pancreas.

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(PMID = 21048849.001).

[ISSN] 1687-9678

[Journal-full-title] Stem cells international

[ISO-abbreviation] Stem Cells Int

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Other-IDs] NLM/ PMC2956457

   

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The surgical jaundice can be caused by the obstruction of the bile duct as with gall stones, strictures, malignancy, such as cholangiocarcinoma (in which the jaundice is persistent and progressive), periampullary carcinoma, carcinoma gall bladder and carcinoma head of pancreas.

Malignant obstructive jaundice was seen in 34 (56.66%) patients while 26 (43.33%) had benign etiology.

Amongst the commonest symptom; clay coloured stools (75%) was more frequent in patients with malignant disease whereas abdominal pain (51.66%) was most common in benign conditions.

Commonest malignancy was Carcinoma (Ca) of the head of pancreas 18/60 (30%) followed by Ca gall bladder 8/60 (13.33%), cholangiocarcinoma 7/60 (11.66%), and periampullary carcinoma 1/60 (1.66%).

Choledocholithiasis 21/60 (35%) was the commonest benign cause followed by stricture of common bile duct 3/60 (5%) and acute pancreatitis 2/60 (3.33%).

Ca head of pancreas is the commonest malignancy while Choledocholithiasis is the commonest benign cause.

[MeSH-major] Jaundice, Obstructive / diagnosis. Jaundice, Obstructive / etiology

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(PMID = 19999207.001).

[ISSN] 1025-9589

[Journal-full-title] Journal of Ayub Medical College, Abbottabad : JAMC

[ISO-abbreviation] J Ayub Med Coll Abbottabad

[Language] eng

[Publication-type] Journal Article

[Publication-country] Pakistan

   

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At the end of each experimental period, the broilers were euthanized and the contents of the ileum, duodenum and jejunum (pooled), and pancreas were removed for analysis.

The pancreas and duodenal-jejunal samples were analyzed for proteolytic and amylase activity to determine the influence of practical levels of phytate on enzyme activity.

Results showed that neither phytase nor glucanase influenced enzyme activity in the digesta or pancreas, suggesting that practical levels of phytate did not influence the activity of proteolytic enzymes or amylase.

The IDE and DM digestibility of corn and the digesta and pancreatic enzyme activities increased with age, whereas the IDE of SBM was similar among age groups.

[MeSH-minor] Aging. Animal Nutritional Physiological Phenomena. Animals. Diet / veterinary. Dietary Supplements. Energy Metabolism / drug effects. Male. Pancreas. Soybeans / metabolism. Zea mays / metabolism

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(PMID = 17954585.001).

[ISSN] 0032-5791

[Journal-full-title] Poultry science

[ISO-abbreviation] Poult. Sci.

[Language] eng

[Publication-type] Controlled Clinical Trial; Journal Article

[Publication-country] United States

[Chemical-registry-number] EC 3.1.3.26 / 6-Phytase; EC 3.2.1.- / Glycoside Hydrolases

   

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[Title] Islet yield after different methods of pancreatic Liberase delivery.

OBJECTIVE: Enzymatic digestion of the pancreas is a fundamental step in islet isolation and there are many ways to administer the enzyme during procurement.

The aim of this study was to evaluate the influence of different methods of Liberase delivery during pancreas harvest on the quality and quantity of islets.

After injection, the pancreata were harvested, digested in Liberase solution, mechanically disrupted, and purified using discontinuous gradient centrifugation.

CONCLUSION: Intraductal administration is the best enzyme delivery method for pancreatic islet isolation.

The pancreatic ducts are the most anatomic and physiological way to transport the enzyme uniformly inside the pancreas, determining an adequate digestion and better islet quantity and quality when compared with other delivery methods.

[MeSH-major] Collagenases. Islets of Langerhans / cytology. Pancreas / cytology. Thermolysin

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(PMID = 17275501.001).

[ISSN] 0041-1345

[Journal-full-title] Transplantation proceedings

[ISO-abbreviation] Transplant. Proc.

[Language] eng

[Grant] United States / NIDDK NIH HHS / DK / R03 DK58965-01

[Publication-type] Journal Article; Research Support, N.I.H., Extramural

[Publication-country] United States

[Chemical-registry-number] EC 3.4.24.- / Collagenases; EC 3.4.24.- / Liberase; EC 3.4.24.27 / Thermolysin

   

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[Title] Development of islet-like cell clusters after pancreas transplantation in the spontaneously diabetic Torri rat.

Pancreas transplantation (PTx) has evolved as a clinical therapy to achieve sustained euglycemia.

However, it remains unclear if naive diseased islets of the pancreas benefit from the avoidance of glucose toxicity by PTx.

Moreover, we found that the beta-cell mass was significantly increased in the naive pancreases of 40-week-old PTx recipients (PTx40-naive).

Interestingly, islet-like cell clusters of varying size were found close to ductal structures of PTx40-naive pancreases, suggesting that these cells are derived from ductal cells.

Furthermore, pancreatic and duodenal homeobox factor-1 (PDX-1) was more clearly expressed in the nuclei of PTx40-naive pancreatic islet-like cell clusters.

Our results demonstrate the development of duct-derived beta cells in the pancreas of type 2 diabetic recipients after PTx.

[MeSH-major] Diabetes Mellitus, Experimental / pathology. Islets of Langerhans / cytology. Pancreas Transplantation / methods. Pancreas Transplantation / pathology

[MeSH-minor] Age of Onset. Animals. Blotting, Western. Cell Nucleus / metabolism. Cell Proliferation. Disease Models, Animal. Glucagon / chemistry. Glucose / pharmacology. Glucose / toxicity. Glucose Tolerance Test. Homeodomain Proteins / biosynthesis. Immunohistochemistry. Insulin / chemistry. Insulin / metabolism. Insulin / pharmacology. Insulin-Secreting Cells / cytology. Islets of Langerhans Transplantation / methods. Ki-67 Antigen / biosynthesis. Male. Pancreas / metabolism. Pancreas / pathology. Rats. Time Factors. Trans-Activators / biosynthesis

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(PMID = 16162183.001).

[ISSN] 1600-6135

[Journal-full-title] American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

[ISO-abbreviation] Am. J. Transplant.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Denmark

[Chemical-registry-number] 0 / Homeodomain Proteins; 0 / Insulin; 0 / Ki-67 Antigen; 0 / Trans-Activators; 0 / pancreatic and duodenal homeobox 1 protein; 9007-92-5 / Glucagon; IY9XDZ35W2 / Glucose

   

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[Title] A systematic review on endoscopic detection rate, endotherapy, and surgery for pancreas divisum.

BACKGROUND AND STUDY AIMS: The rates for endoscopic detection of pancreas divisum at routine endoscopic retrograde cholangiopancreatography (ERCP) vary worldwide, and the sample sizes in the reported studies on endoscopy and surgery for pancreas divisum are very small and variable.

The aim of this study was to systematically analyze the pooled data and determine endoscopic detection rates for pancreas divisum and pain relief rates in patients with pancreas divisum after endotherapy or surgery.

MATERIALS AND METHODS: A search for published data was performed by using the Medline database (1950 to 1st May 2008) with "pancreas divisum" as the keyword.

Publications, mainly on endoscopic detection rate, endotherapy, or surgery for pancreas divisum, were deemed relevant, and were further fully reviewed and analyzed.

The overall endoscopic detection rate for pancreas divisum was 2.9% (899/31,413), with the rate being significantly higher in the United States (5.8%) and Europe (6.0%) than in Asia (1.5%) (both P < 0.001).

In addition, there were significant differences in the combined response rates (for endotherapy and for surgery) between patients with pancreas divisum of acute recurrent pancreatitis (ARP)-type (81.2 %) compared with chronic pancreatitis-type (68.8%), and between ARP-type and pain-type (53.1%) (both P < 0.05).

CONCLUSIONS: The endoscopic detection rate for pancreas divisum is much higher in western countries than in Asian countries.

The pooled response rates of patients with pancreas divisum to endotherapy and surgery are similar in the reported series.

Patients with ARP-type pancreas divisum respond better to endotherapy or surgery than those with chronic pancreatitis-type and pain-type.

[MeSH-major] Cholangiopancreatography, Endoscopic Retrograde. Pancreas / abnormalities. Pancreatitis, Acute Necrotizing / diagnosis. Pancreatitis, Chronic / diagnosis

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(PMID = 19337962.001).

[ISSN] 1438-8812

[Journal-full-title] Endoscopy

[ISO-abbreviation] Endoscopy

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] Germany

[Chemical-registry-number] EC 3.1.1.3 / Lipase; EC 3.2.1.- / Amylases

[Number-of-references] 51

   

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[Title] The pathway to the closed-loop artificial pancreas: research and commercial perspectives.

In addition, artificial pancreas (AP) research has progressed to clinical studies, using combinations of commercially available devices.

[MeSH-major] Diabetes Mellitus / drug therapy. Diabetes Mellitus / metabolism. Insulin Infusion Systems. Pancreas, Artificial

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(PMID = 20877259.001).

[ISSN] 1565-4753

[Journal-full-title] Pediatric endocrinology reviews : PER

[ISO-abbreviation] Pediatr Endocrinol Rev

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] Israel

   

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[Title] Diffusion-weighted magnetic resonance imaging of pancreas tumours.

The purpose of this study was to evaluate the accuracy of diffusion-weighted imaging (DWI) in diagnosis of pancreas cancer, to compare DWI with a conventional comprehensive MRI (MRI-c) and to analyse apparent diffusion coefficient (ADC) values of lesions.

Thirty-six patients with pancreatic lesions (12 malignant and 24 benign) and 39 patients without lesions were included.

Mean ADC values of malignant lesions were significantly lower than those of benign lesions.

DWI has a similar accuracy to MRI-c in diagnosis of pancreas cancer.

[MeSH-major] Diffusion Magnetic Resonance Imaging / methods. Pancreatic Neoplasms / diagnosis

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[CommentIn] Eur Radiol. 2010 Jul;20(7):1768-9; author reply 1770-1 [20204646.001]

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(PMID = 19308414.001).

[ISSN] 1432-1084

[Journal-full-title] European radiology

[ISO-abbreviation] Eur Radiol

[Language] eng

[Publication-type] Comparative Study; Evaluation Studies; Journal Article

[Publication-country] Germany

   

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[Title] [Protective effect of heme oxygenase-1 induction in vivo to pancreas islet xenograft].

OBJECTIVE: To study the protective effect of islet xenograft and its possible mechanism of high expression of heme oxygenase-1 (HO-1) in donor pancreas islet induced by cobalt protoporphyrin (CoPP).

[MeSH-major] Heme Oxygenase-1 / metabolism. Pancreas Transplantation

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(PMID = 19781175.001).

[ISSN] 0529-5815

[Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]

[ISO-abbreviation] Zhonghua Wai Ke Za Zhi

[Language] chi

[Publication-type] English Abstract; Journal Article

[Publication-country] China

[Chemical-registry-number] 0 / Protoporphyrins; 130068-27-8 / Interleukin-10; 63AAN3JDZE / cobaltiprotoporphyrin; EC 1.14.99.3 / Heme Oxygenase-1

   

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[Title] Intraductal papillary mucinous tumors of the pancreas: biology, diagnosis, and treatment.

Pancreatic intraductal papillary mucinous neoplasms (IPMNs) rank among the most common cystic tumors of the pancreas.

[MeSH-major] Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / therapy

[MeSH-minor] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / metabolism. Adenocarcinoma, Mucinous / therapy. Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Pancreatic Ductal / metabolism. Carcinoma, Pancreatic Ductal / therapy. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / therapy. Humans. Prognosis

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(PMID = 21147870.001).

[ISSN] 1549-490X

[Journal-full-title] The oncologist

[ISO-abbreviation] Oncologist

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

[Other-IDs] NLM/ PMC3227924

   

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[Title] In vitro transdifferentiation of human hepatoma cells into pancreatic-like cells.

Transdifferentiation from different cellular origins into pancreatic-like beta-cells is of clinical significance since this approach may offer a potential cure for diabetes.

In order to achieve this goal, the liver is considered as a suitable candidate due to its close developmental relationship to the pancreas, its large size and a well-documented regenerative capacity that could provide enough original tissues to initiate the transdifferentiation procedure.

In this chapter, we describe a protocol to overexpress Pdx1, a master regulator essential for pancreas development in the cultured human liver cell line, HepG2.

[MeSH-major] Carcinoma, Hepatocellular / pathology. Cell Differentiation. Cytological Techniques. Liver Neoplasms / pathology. Pancreas / cytology

[MeSH-minor] Cell Line, Tumor. Cell Transdifferentiation. Humans. Insulin-Secreting Cells / cytology

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(PMID = 19504247.001).

[ISSN] 1940-6029

[Journal-full-title] Methods in molecular biology (Clifton, N.J.)

[ISO-abbreviation] Methods Mol. Biol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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[Title] Detection of proteolytic cleavages of diabetes-associated protein IA-2 beta in the pancreas and the brain using novel anti-IA-2 beta monoclonal antibodies.

IA-2 beta exists mainly in a 60-kDa form, and is frequently located in the dense-core secretory vesicles of pancreatic beta cells.

In the present study, we characterized the major forms of IA-2 beta in the brain and pancreas of normal and non-obese diabetic (NOD) mice.

On the contrary, only the 60-kDa isoform of IA-2 beta was expressed in the mouse pancreas and in the mouse pancreatic beta cell line, MIN6.

Furthermore, Western blotting and immunohistochemistry demonstrated that NOD mice expressed similar isoforms present in the brains and pancreatic islets of C57BL/6J, BALC/CA and ICR mice, accordingly.

[MeSH-major] Antibodies, Monoclonal / pharmacology. Autoantigens / analysis. Autoantigens / immunology. Autoantigens / metabolism. Brain / metabolism. Membrane Proteins / analysis. Membrane Proteins / immunology. Membrane Proteins / metabolism. Pancreas / metabolism. Protein Tyrosine Phosphatases / analysis. Protein Tyrosine Phosphatases / immunology. Protein Tyrosine Phosphatases / metabolism

[MeSH-minor] Amino Acid Sequence. Animals. Diabetes Mellitus, Type 1 / enzymology. Isoenzymes / metabolism. Mice. Mice, Inbred BALB C. Mice, Inbred C57BL. Mice, Inbred ICR. Mice, Inbred NOD. Mice, Nude. Mice, Transgenic. Molecular Sequence Data. Peptide Fragments / analysis. Protein Processing, Post-Translational. Protein Tyrosine Phosphatase, Non-Receptor Type 1. Receptor-Like Protein Tyrosine Phosphatases, Class 8. Tumor Cells, Cultured

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(PMID = 17611635.001).

[ISSN] 1107-3756

[Journal-full-title] International journal of molecular medicine

[ISO-abbreviation] Int. J. Mol. Med.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Greece

[Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Autoantigens; 0 / Isoenzymes; 0 / Membrane Proteins; 0 / Peptide Fragments; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 1; EC 3.1.3.48 / Protein Tyrosine Phosphatases; EC 3.1.3.48 / Ptprn protein, mouse; EC 3.1.3.48 / Receptor-Like Protein Tyrosine Phosphatases, Class 8

   

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[Title] Solid pseudopapillary tumor of the pancreas: a review of salient clinical and pathologic features.

Solid pseudopapillary tumor (SPT) of the pancreas is a rare tumor of uncertain histogenesis characterized, as the name suggests, by a cystic and solid pattern of growth with formation of pseudopapillae.

Accounting for only a small percentage of pancreatic neoplasms, SPT occurs primarily in young women, although cases in older patients and men have been reported.

The tumor is thought to have low-grade malignant potential, as the majority of the cases are cured by simple but complete surgical resection.

Knowledge of the unique morphologic and demographic characteristics of this neoplasm is essential for accurate diagnosis.

Herein, we review the clinical and pathologic features, which can help separate SPTs from other primary pancreatic tumors.

[MeSH-major] Carcinoma, Papillary / pathology. Pancreatic Neoplasms / pathology

[MeSH-minor] Diagnosis, Differential. Humans. Immunophenotyping. Pancreatic Cyst / diagnosis. Pancreatic Cyst / immunology. Pancreatic Cyst / pathology. Prognosis

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(PMID = 18156811.001).

[ISSN] 1072-4109

[Journal-full-title] Advances in anatomic pathology

[ISO-abbreviation] Adv Anat Pathol

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

[Number-of-references] 51

   

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[Title] Heterotopic pancreas: typical and atypical imaging findings.

Heterotopic pancreas is a common condition often encountered during laporotomy or autopsy.

Prospective radiographic diagnosis is challenging because of the variable imaging appearances.

The purpose of this review is to present the typical and atypical appearances of heterotopic pancreas on imaging studies.

[MeSH-major] Choristoma / diagnosis. Gastrointestinal Diseases / diagnosis. Pancreas

[MeSH-minor] Adolescent. Adult. Biomarkers / blood. Diagnosis, Differential. Endosonography. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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(PMID = 20380941.001).

[ISSN] 1365-229X

[Journal-full-title] Clinical radiology

[ISO-abbreviation] Clin Radiol

[Language] eng

[Publication-type] Case Reports; Journal Article; Review

[Publication-country] England

[Chemical-registry-number] 0 / Biomarkers

[Number-of-references] 25

   

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[Title] [Clinical and morphological characteristics of intraductal papillary mucinous tumors of the pancreas].

The paper presents the results of a comprehensive morphological study of the surgical material from 5 patients (males aged 49 to 69 years) with intraductal papillary mucinous tumors (IDPMT) of the pancreas.

The pancreatobiliary type of IDPMT was established in 4 cases (one adenoma from the peripheral branches of the pancreatic duct, one IDPMT with the borderline malignancy potential from the major pancreatic duct, and two intraductal papillary mucinous carcinomas from the major pancreatic duct).

One patient was diagnosed as having an enteric type of a tumor (IDPMT with the borderline malignancy from the major pancreatic duct), which was characterized by the expression in the MUC2 and MUC5AC cells and by that of cytokeratin 20.

[MeSH-major] Adenocarcinoma, Mucinous / metabolism. Adenocarcinoma, Mucinous / pathology. Adenoma / metabolism. Adenoma / pathology. Carcinoma, Pancreatic Ductal / metabolism. Carcinoma, Pancreatic Ductal / pathology

[MeSH-minor] Aged. Gene Expression Regulation, Neoplastic. Humans. Keratins / biosynthesis. Male. Middle Aged. Mucin 5AC / biosynthesis. Mucin-1 / biosynthesis. Neoplasm Proteins / biosynthesis

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(PMID = 19507570.001).

[ISSN] 0004-1955

[Journal-full-title] Arkhiv patologii

[ISO-abbreviation] Arkh. Patol.

[Language] rus

[Publication-type] English Abstract; Journal Article

[Publication-country] Russia (Federation)

[Chemical-registry-number] 0 / MUC1 protein, human; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucin-1; 0 / Neoplasm Proteins; 68238-35-7 / Keratins

   

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[Title] Pancreatic adenocarcinoma: dynamic 64-slice helical CT with perfusion imaging.

Thus, in lesions of the tissues of the pancreas, this offers to increase the accuracy of CT diagnosis.

In this study, our aim was to explore the perfusion characteristics of normal pancreas and pancreatic adenocarcinoma.

METHODS: Dynamic 64-slice helical CT was conducted in 36 patients with non-pancreatic disease and in 40 patients with histopathologically proven pancreatic adenocarcinoma.

RESULTS: There was no significant difference noted between the distribution of BF, BV, and PS values in different regions of the pancreas, namely the head, neck, body, and tail (P > 0.05).

The BF, BV, and PS of normal pancreas were recorded as 135.24 +/- 48.36 ml min(-1) 100 g(-1), 200.55 +/- 54.96 ml 100 g(-1), and 49.75 +/- 24.27 ml min(-1) 100 g(-1), respectively.

BF, BV, and PS values of the tumor tissue of pancreatic adenocarcinoma decreased significantly compared to normal pancreas (P < 0.05).

CONCLUSIONS: Normal pancreas appears homogenous on perfusion CT.

A significant decrease of BF, BV, and PS was observed in pancreatic adenocarcinoma.

Dynamic 64-slice helical CT with perfusion imaging should be considered a potential modality to increase the accuracy of CT diagnosis for pancreatic adenocarcinoma.

[MeSH-major] Adenocarcinoma / radiography. Pancreatic Neoplasms / radiography. Tomography, Spiral Computed / methods

[MeSH-minor] Case-Control Studies. Contrast Media. Female. Humans. Iohexol. Male. Middle Aged. Pancreas / blood supply. Pancreas / radiography. Pancreaticoduodenectomy. Prospective Studies

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(PMID = 19672566.001).

[ISSN] 1432-0509

[Journal-full-title] Abdominal imaging

[ISO-abbreviation] Abdom Imaging

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Contrast Media; 4419T9MX03 / Iohexol

   

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[Title] Identification and characterization of a novel expandable adult stem/progenitor cell population in the human exocrine pancreas.

In particular, the existence of pancreatic stem cells remains elusive because specific markers for their identification are not available.

We established a method for the isolation of a population of stem/progenitor cells from the human exocrine pancreas, and propose it as a model for other human compact organs.

We identified a novel predominant functional type of stem/progenitor cell within the human exocrine pancreas, able to generate insulin-producing cells and potentially non-pancreatic cells.

[MeSH-major] Cell Proliferation. Pancreas, Exocrine / cytology. Stem Cells / cytology

[MeSH-minor] Adult. Cell Differentiation / physiology. Cell Line, Tumor. Cells, Cultured. Coculture Techniques / methods. Humans

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(PMID = 18591892.001).

[ISSN] 1720-8386

[Journal-full-title] Journal of endocrinological investigation

[ISO-abbreviation] J. Endocrinol. Invest.

[Language] eng

[Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Italy

   

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[Title] Risk factors for pancreatic anastomotic leakage: the significance of preoperative dynamic magnetic resonance imaging of the pancreas as a predictor of leakage.

BACKGROUND: The histologic degree of pancreatic fibrosis can be assessed preoperatively by using the time-signal intensity curve (TIC) of the pancreas obtained from dynamic magnetic resonance imaging.

STUDY DESIGN: To identify risk factors for postoperative pancreatic anastomotic leakage and to assess the impact of pancreatic TIC on this complication, 89 patients who underwent a pancreatic head resection with an end-to-side pancreaticojejunostomy between December 1998 and August 2005 were retrospectively reviewed.

The pancreatic TIC profiles were classified into 3 types: type I, indicating a normal pancreas without fibrosis; and types II and III indicating fibrotic pancreas.

In a univariate analysis, pancreatic texture (hard, 3% versus intermediate, 20% versus soft, 23%; p = 0.046), pancreatic duct size (> 3 mm, 8% versus <or= 3 mm, 25%; p = 0.037), and pancreatic TIC (types II, III, 3% versus type I, 25%; p = 0.006) were notably associated with pancreatic anastomotic leakage.

In a multivariable analysis, pancreatic TIC (odds ratio [OR], 9.58; 95% CI, 1.1 to 91.7) was the only marked independent predictor of postoperative pancreatic leakage.

A subanalysis of 52 patients with type I pancreatic TIC demonstrated hemoglobin A1c (odds ratio, 9.81; 95% CI, 1.2 to 127.9) to be a notable predictor of leakage and pancreatic leakage developed in diabetic patients with a high hemoglobin A1c concentration (> 6.0%) than in those with a normal hemoglobin A1c level.

CONCLUSIONS: Pancreatic TIC from dynamic MRI provides reliable information for predicting risk of pancreatic anastomotic leakage after pancreatic head resection.

Especially in patients with type I pancreatic TIC, the presence of uncontrolled diabetes is considered a primary risk factor for postoperative pancreatic leakage.

[MeSH-major] Anastomosis, Surgical / adverse effects. Magnetic Resonance Imaging. Pancreatic Diseases / surgery. Pancreaticojejunostomy. Postoperative Complications / diagnosis

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(PMID = 16648011.001).

[ISSN] 1072-7515

[Journal-full-title] Journal of the American College of Surgeons

[ISO-abbreviation] J. Am. Coll. Surg.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Contrast Media

   

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[Title] Identification of transcripts with enriched expression in the developing and adult pancreas.

BACKGROUND: Despite recent advances, the transcriptional hierarchy driving pancreas organogenesis remains largely unknown, in part due to the paucity of comprehensive analyses.

To address this deficit we generated ten SAGE libraries from the developing murine pancreas spanning Theiler stages 17-26, making use of available Pdx1 enhanced green fluorescent protein (EGFP) and Neurog3 EGFP reporter strains, as well as tissue from adult islets and ducts.

RESULTS: We used a specificity metric to identify 2,536 tags with pancreas-enriched expression compared to 195 other mouse SAGE libraries.

We subsequently grouped co-expressed transcripts with differential expression during pancreas development using K-means clustering.

We validated the clusters first using quantitative real time PCR and then by analyzing the Theiler stage 22 pancreas in situ hybridization staining patterns of over 600 of the identified genes using the GenePaint database.

These were then categorized into one of the five expression domains within the developing pancreas.

Based on these results we identified a cascade of transcriptional regulators expressed in the endocrine pancreas lineage and, from this, we developed a predictive regulatory network describing beta-cell development.

CONCLUSION: Taken together, this work provides evidence that the SAGE libraries generated here are a valuable resource for continuing to elucidate the molecular mechanisms regulating pancreas development.

Furthermore, our studies provide a comprehensive analysis of pancreas development, and insights into the regulatory networks driving this process are revealed.

[MeSH-major] Gene Expression Profiling. Pancreas / embryology

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(PMID = 18554416.001).

[ISSN] 1474-760X

[Journal-full-title] Genome biology

[ISO-abbreviation] Genome Biol.

[Language] eng

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / enhanced green fluorescent protein; 147336-22-9 / Green Fluorescent Proteins

[Other-IDs] NLM/ PMC2481431

   

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[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Randomized double-blind phase II trial comparing gemcitabine plus LY293111 versus gemcitabine plus placebo in advanced adenocarcinoma of the pancreas.

BACKGROUND: LY293111 (LY) is a novel oral anticancer agent with leukotriene B4 receptor antagonist and peroxisome proliferator-activated receptor gamma agonist properties, producing promising results alone and in combination with gemcitabine in pancreatic cancer xenograft models.

PATIENTS AND METHODS: Chemotherapy-naive patients with histologically confirmed locally advanced or metastatic adenocarcinoma of the pancreas were randomly assigned to gemcitabine 1000 mg/m on days 1, 8, and 15 of a 28-day cycle and continuously administered LY 600 mg twice daily or gemcitabine 1000 mg/m on days 1, 8, and 15 of a 28-day cycle and daily oral placebo.

CONCLUSIONS: These results do not demonstrate any benefit to adding LY to gemcitabine in unpretreated patients with advanced pancreatic carcinoma.

[MeSH-major] Adenocarcinoma / drug therapy. Antimetabolites, Antineoplastic / therapeutic use. Benzoates / therapeutic use. Deoxycytidine / analogs & derivatives. Pancreatic Neoplasms / drug therapy

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(PMID = 19672152.001).

[ISSN] 1528-9117

[Journal-full-title] Cancer journal (Sudbury, Mass.)

[ISO-abbreviation] Cancer J

[Language] eng

[Publication-type] Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Benzoates; 0 / LY 293111; 0 / Receptors, Leukotriene B4; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine

   

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[Title] Giant aneurysm of the splenic artery adherent to the pancreas with splenic infarct: report of a case.

We present a case of a 9 cm giant splenic artery aneurysm tightly adherent to the pancreas which was treated surgically.

[MeSH-major] Aneurysm / diagnosis. Splenic Artery / surgery. Splenic Infarction / diagnosis

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(PMID = 16910011.001).

[ISSN] 0001-5458

[Journal-full-title] Acta chirurgica Belgica

[ISO-abbreviation] Acta Chir. Belg.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Belgium

   

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Subcapsular hematoma of the spleen is a rare complication of pancreatitis despite its close proximity to the pancreas.

Pancreatic pseudocyst involving the tail of the pancreas may erode into the splenic hilum causing hilar vessel bleeding with subcapsular dissection and hematoma formation.

[MeSH-major] Gastrointestinal Hemorrhage / diagnosis. Hematoma / diagnosis. Pancreatic Pseudocyst / diagnosis. Pancreatitis / diagnosis. Splenic Rupture / diagnosis

[MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Adult. Follow-Up Studies. Hemodynamics / physiology. Humans. Magnetic Resonance Imaging. Male. Remission, Spontaneous. Risk Assessment. Tomography, X-Ray Computed. Ultrasonography, Doppler

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(PMID = 16447482.001).

[ISSN] 0003-1348

[Journal-full-title] The American surgeon

[ISO-abbreviation] Am Surg

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

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[Title] Differential activation of adenylate cyclase by secretin and VIP receptors in the calf pancreas.

OBJECTIVE: Secretin is a key regulator of pancreatic secretion, but the molecular basis of its action is not well understood, especially in the calf pancreas.

Our study investigated the expression and functional competence of secretin receptors (SEC-R) in calf pancreatic membranes.

RESULTS: We successfully amplified, by reverse transcriptase-polymerase chain reaction, a fragment of the SEC-R gene from 119-day-old calf pancreas.

Accordingly, secretin stimulates AC activity in calf pancreatic membranes isolated from 28- and 119-day-old animals with a potency (Ka) of 1.9 to 2.7 nmol/L.

CONCLUSION: Our data indicate that secretin exerts a direct action on pancreatic secretion through specific SEC-R coupled to the AC system.

Calf pancreatic SEC-Rs are coexpressed with VIP-2 receptors that we previously identified by ligand binding and cross-linking experiments.

[MeSH-major] Adenylyl Cyclases / metabolism. Pancreas / metabolism. Receptors, G-Protein-Coupled / genetics. Receptors, Gastrointestinal Hormone / genetics. Receptors, Vasoactive Intestinal Peptide, Type II / metabolism. Receptors, Vasoactive Intestinal Polypeptide, Type I / metabolism. Secretin / metabolism

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(PMID = 16025005.001).

[ISSN] 1536-4828

[Journal-full-title] Pancreas

[ISO-abbreviation] Pancreas

[Language] eng

[Databank-accession-numbers] GENBANK/ AF118556

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Pituitary Adenylate Cyclase-Activating Polypeptide; 0 / Receptors, G-Protein-Coupled; 0 / Receptors, Gastrointestinal Hormone; 0 / Receptors, Vasoactive Intestinal Peptide, Type II; 0 / Receptors, Vasoactive Intestinal Polypeptide, Type I; 0 / secretin receptor; 1393-25-5 / Secretin; 37221-79-7 / Vasoactive Intestinal Peptide; EC 4.6.1.1 / Adenylyl Cyclases

   

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[Title] Histologic assessment and grading of the exocrine pancreas in the dog.

Histologic grading schemes for canine inflammatory conditions are sparse, and in the case of the canine pancreas, have not been previously described.

In a previous study, we determined that histologic lesions of the exocrine pancreas occurred much more frequently than gross lesions.

The intention of the current study was to develop a histologic grading scheme for nonneoplastic lesions following extensive assessment of the exocrine pancreas from dogs presented for necropsy examination.

The parameters of the proposed scheme include neutrophilic inflammation, lymphocytic inflammation, pancreatic necrosis, pancreatic fat necrosis, edema, fibrosis, atrophy, and hyperplastic nodules.

In this case series, the most common lesion was pancreatic hyperplastic nodules (80.2%), followed by lymphocytic inflammation (52.5%), fibrosis (49.5%), atrophy (46.5%), neutrophilic inflammation (31.7%), pancreatic fat necrosis (25.7%), pancreatic necrosis (16.8%), and edema (9.9%).

Neutrophilic inflammation, when present, was often associated with necrosis (pancreatic necrosis, pancreatic fat necrosis, or both) and occasionally with hyperplastic nodules.

The utilization of a grading scheme for exocrine pancreatic lesions will be useful in advancing the classification of exocrine pancreatic disease in the dog, which may lead to multicenter studies of exocrine pancreatic disorders in the dog and in other species.

[MeSH-major] Dog Diseases / pathology. Pancreas, Exocrine / pathology. Pancreatitis / veterinary

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(PMID = 16566269.001).

[ISSN] 1040-6387

[Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

[ISO-abbreviation] J. Vet. Diagn. Invest.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

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[Title] Early morbidity after pancreas transplantation.

This study aims to evaluate and compare the early outcome of both pancreas-alone transplantation (PTA) and simultaneous kidney-pancreas transplantation (SPKT) focusing on the complications affecting the first month after the procedures.

[MeSH-major] Kidney Transplantation / adverse effects. Kidney Transplantation / methods. Pancreas Transplantation / adverse effects. Pancreas Transplantation / methods

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(PMID = 16297054.001).

[ISSN] 0934-0874

[Journal-full-title] Transplant international : official journal of the European Society for Organ Transplantation

[ISO-abbreviation] Transpl. Int.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Germany

[Chemical-registry-number] 0 / Blood Glucose; 0 / Immunosuppressive Agents; 0 / Insulin

   

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[Title] Valproate and copper accelerate TRH-like peptide synthesis in male rat pancreas and reproductive tissues.

Because high levels of TRH-like peptides occur in the pancreas and pGlu-Glu-Pro-NH(2) (Glu-TRH) has been shown to be a fertilization promoting peptide, we hypothesized that these peptides mediate some of the metabolic and reproductive side effects of Valp.

AC, CHR and WD treatments significantly altered TRH and/or TRH-like peptide levels in pancreas and reproductive tissues.

Phe-TRH, the most abundant TRH-like peptide in the pancreas, increased 4-fold with AC Valp.

Copper (500 microM) increased the in vitro C-terminal amidation of TRH-like peptides by 8- and 4-fold during 24 degrees C incubation of homogenates of pancreas and testis, respectively.

Valp (7 microM) accelerated 3-fold the processing of TRH and TRH-like peptide precursors in pancreatic LDCV's incubated at 24 degrees C.

[MeSH-major] Copper / pharmacology. Genitalia, Male / drug effects. Pancreas / drug effects. Peptides / metabolism. Thyrotropin-Releasing Hormone / metabolism. Valproic Acid / pharmacology

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(PMID = 16945452.001).

[ISSN] 0196-9781

[Journal-full-title] Peptides

[ISO-abbreviation] Peptides

[Language] eng

[Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

[Publication-country] United States

[Chemical-registry-number] 0 / Blood Glucose; 0 / Peptides; 5Y5F15120W / Thyrotropin-Releasing Hormone; 614OI1Z5WI / Valproic Acid; 789U1901C5 / Copper

   

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[Title] Outcome of pancreas transplantation in recipients older than 50 years: a single-centre experience.

BACKGROUND: Pancreas transplantation (PT) remains the only treatment that can restore insulin independence among insulin-dependent diabetics.

So, as the incidence of other surgical complication in the more than or equal to 50 group compared with less than 50 (graft thrombosis 13% vs. 11.5%; bleeding 19% vs. 6.7%; abdominal abscess 23% vs. 19%; pancreatic leak 13% vs. 9.6%).

One-year patient survival was 88% in more than or equal to 50 vs. 92% in less than 50 group, P=0.399; and pancreas graft survival rate was similar (79% in the >or=50 and 74% in <50, P=0.399).

[MeSH-major] Pancreas Transplantation / methods

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(PMID = 19077882.001).

[ISSN] 1534-6080

[Journal-full-title] Transplantation

[ISO-abbreviation] Transplantation

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States