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1. Emmez H, Kaymaz M, Tokgöz N, Yilmaz G, Kurt G: Progression of a lumbar spinal osteoblastoma. Neurol Med Chir (Tokyo); 2005 Jul;45(7):379-83
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  • [Title] Progression of a lumbar spinal osteoblastoma.
  • A 24-year-old woman presented with a lumbar spinal osteoblastoma manifesting as a 5-year history of low back pain radiating to the left foot.
  • Primary benign bone tumors such as osteoblastoma and osteoid osteoma should be considered in the differential diagnosis of back pain and the patients should be followed up carefully.
  • [MeSH-major] Lumbar Vertebrae. Magnetic Resonance Imaging. Osteoblastoma / diagnosis. Radionuclide Imaging. Spinal Neoplasms / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 16041187.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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2. Samdani A, Torre-Healy A, Chou D, Cahill AM, Storm PB: Treatment of osteoblastoma at C7: a multidisciplinary approach. A case report and review of the literature. Eur Spine J; 2009 Jul;18 Suppl 2:196-200
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  • [Title] Treatment of osteoblastoma at C7: a multidisciplinary approach. A case report and review of the literature.
  • Osteoblastoma is a rare benign bone tumor that presents with back pain and occurs in the spine approximately 40% of the time.
  • The time from onset of symptoms to diagnosis is typically several months because it is a rare entity and radiographic studies are often negative early in the course of the disease.
  • [MeSH-major] Cervical Vertebrae. Embolization, Therapeutic / methods. Osteoblastoma / therapy. Spinal Fusion / methods. Spinal Neoplasms / therapy

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  • (PMID = 18839223.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 25
  • [Other-IDs] NLM/ PMC2899567
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3. Lypka MA, Goos RR, Yamashita DD, Melrose R: Aggressive osteoblastoma of the mandible. Int J Oral Maxillofac Surg; 2008 Jul;37(7):675-8
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  • [Title] Aggressive osteoblastoma of the mandible.
  • We report a case of aggressive osteoblastoma of the mandible, an extremely rare primary bone tumor of the maxillofacial skeleton.
  • Although osteoblastomas are benign tumors requiring only curettage for cure, there is a small subset of tumors that exhibit locally aggressive behavior and have atypical histopathologic features.
  • The correct diagnosis must be based on clinical, radiographic and pathologic features.
  • [MeSH-major] Mandibular Neoplasms / diagnosis. Osteoblastoma / diagnosis
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Radiography, Panoramic. Reconstructive Surgical Procedures. Tomography, X-Ray Computed

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  • (PMID = 18337062.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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4. Louaste J, Amhajji L, Chkoura M, Rachid K: [Osteoblastoma in the proximal radio ulnar joint]. Chir Main; 2007 Apr;26(2):117-9
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  • [Title] [Osteoblastoma in the proximal radio ulnar joint].
  • Osteoblastoma is a benign but painful bone tumour, which can only be treated surgically.
  • A delay in diagnosis can, despite successful treatment of the tumour, cause loss of the full range of movements of the elbow.
  • [MeSH-major] Elbow Joint. Osteoblastoma

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  • (PMID = 17470420.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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5. Kyriakos M, El-Khoury GY, McDonald DJ, Buckwalter JA, Sundaram M, DeYoung B, O'Brien MP: Osteoblastomatosis of bone. A benign, multifocal osteoblastic lesion, distinct from osteoid osteoma and osteoblastoma, radiologically simulating a vascular tumor. Skeletal Radiol; 2007 Mar;36(3):237-47
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  • [Title] Osteoblastomatosis of bone. A benign, multifocal osteoblastic lesion, distinct from osteoid osteoma and osteoblastoma, radiologically simulating a vascular tumor.
  • Histologically, the individual lesions had the features of the nidus of osteoid osteoma/osteoblastoma.
  • The process is designated as osteoblastomatosis to indicate its bone-forming character, prominent osteoblast proliferation, and multiplicity.
  • The cases are distinguished from multifocal/multicentric osteoid osteoma and osteoblastoma, and from benign and malignant vascular tumors.
  • [MeSH-major] Bone Neoplasms / diagnosis. Leg Bones / pathology. Osteoblastoma / diagnosis
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Osteoma, Osteoid / diagnosis. Vascular Neoplasms / diagnosis

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  • (PMID = 16639626.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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6. Imperiale A, Moser T, Ben-Sellem D, Mertz L, Gangi A, Constantinesco A: Osteoblastoma and osteoid osteoma: morphofunctional characterization by MRI and dynamic F-18 FDG PET/CT before and after radiofrequency ablation. Clin Nucl Med; 2009 Mar;34(3):184-8
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  • [Title] Osteoblastoma and osteoid osteoma: morphofunctional characterization by MRI and dynamic F-18 FDG PET/CT before and after radiofrequency ablation.
  • Osteoblastoma (OB) and osteoid osteoma (OO) are benign bone-forming tumors frequently involving vertebrae and long bones of the extremities.
  • Bone scan is a complementary, highly sensitive functional technique particularly useful for detection of vertebral OO.
  • F-18 FDG PET/CT could have potentiality in diagnosis and post therapeutic evaluation of patients with OB and OO.
  • [MeSH-major] Bone Neoplasms / pathology. Bone Neoplasms / surgery. Fluorodeoxyglucose F18. Osteoblastoma / pathology. Osteoblastoma / surgery. Osteoma, Osteoid / pathology. Osteoma, Osteoid / surgery

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  • (PMID = 19352289.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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7. Meli GA, Meli L, Chiaramonte R, Riva G, Pero G: Osteoblastoma of the orbit. A case report and review of the literature. Neuroradiol J; 2008 Feb 18;21(1):71-6
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  • [Title] Osteoblastoma of the orbit. A case report and review of the literature.
  • We describe a case of benign orbital tumour involving the frontal sinus and ethmoidal cells.
  • CT findings were typical of "bone tumour of the orbit", histological analysis yielded a diagnosis of benign osteoblastoma.
  • On MRI osteoblastoma shows an iso- low signal both in T1 and in T2 sequences.
  • The orbit is rarely involved by bone tumours, but all bone tumours may theoretically involve the orbit, often making it difficult to establish the right differential diagnosis by imaging.
  • For this reason we also examined the radiological signs of bone tumours involving other portions of the body.
  • Even though many literature reports suggest CT is the landmark in bone tumour diagnosis, we think it should always be accompanied by MRI.
  • MRI is known to overestimate local staging, but its contribution to differential diagnosis among various tumours may be decisive.

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  • (PMID = 24256752.001).
  • [ISSN] 1971-4009
  • [Journal-full-title] The neuroradiology journal
  • [ISO-abbreviation] Neuroradiol J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Mortazavi SM, Wenger D, Asadollahi S, Shariat Torbaghan S, Unni KK, Saberi S: Periosteal osteoblastoma: report of a case with a rare histopathologic presentation and review of the literature. Skeletal Radiol; 2007 Mar;36(3):259-64
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  • [Title] Periosteal osteoblastoma: report of a case with a rare histopathologic presentation and review of the literature.
  • Osteoblastoma is an uncommon benign bone tumor most commonly located in the vertebral column or metaphysis of a long bone.
  • We report a periosteal-based osteoblastoma, arising from the proximal tibia, in a 20-year-old woman who presented with knee swelling and pain of 2-year duration.
  • Histopathologic evaluation disclosed immature bone and osteoid deposition in a vascularized stroma, associated with numerous osteoblasts and osteoclasts rimming the bony trabeculae.
  • Although extremely unusual, the presence of cartilage does not necessarily exclude the diagnosis of osteoblastoma.
  • [MeSH-major] Bone Neoplasms / diagnosis. Knee Joint / pathology. Osteoblastoma / diagnosis. Periosteum / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Tomography, Emission-Computed. Tomography, X-Ray Computed

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  • (PMID = 16868789.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 29
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9. Combalia Aleu A, Popescu D, Pomes J, Palacin A: Long-standing pain in a 25-year-old patient with a non-diagnosed cervical osteoblastoma: a case report. Arch Orthop Trauma Surg; 2008 Jun;128(6):567-71
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  • [Title] Long-standing pain in a 25-year-old patient with a non-diagnosed cervical osteoblastoma: a case report.
  • Benign osteoblastomas are infrequent tumors, representing less than 1% of all bone tumors.
  • We present a case report of a young male that due to the lack of specific symptoms was diagnosed of a cervical osteoblastoma 14 months after the first symptoms.
  • Nowadays, this delay in diagnosis may be avoided by the routine use of MRI or CT for unspecific cervical symptoms.
  • [MeSH-major] Cervical Vertebrae. Osteoblastoma / diagnosis. Spinal Neoplasms / diagnosis

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  • (PMID = 17641905.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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10. James SL, Panicek DM, Davies AM: Bone marrow oedema associated with benign and malignant bone tumours. Eur J Radiol; 2008 Jul;67(1):11-21
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  • [Title] Bone marrow oedema associated with benign and malignant bone tumours.
  • Bone marrow oedema is associated with a wide variety of pathological processes including both benign and malignant bone tumours.
  • This imaging finding in relation to intraosseous tumours can aid in providing a more focused differential diagnosis.
  • In this review, we will discuss the MR imaging of bone marrow oedema surrounding intraosseous neoplasms.
  • Benign lesions commonly associated with bone marrow oedema include osteoid osteoma, osteoblastoma, chondroblastoma and Langerhan's cell histiocytosis.
  • Metastases and malignant primary bone tumours such as osteosarcoma, Ewing's sarcoma and chondrosarcoma may also be surrounded by bone marrow oedema.
  • Finally, the importance of bone marrow oedema in assessment of post chemotherapeutic response is addressed.
  • [MeSH-major] Bone Marrow Diseases / complications. Bone Marrow Diseases / diagnosis. Bone Neoplasms / complications. Bone Neoplasms / diagnosis. Diagnostic Imaging / methods. Edema / complications. Edema / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans


11. Mir NA, Baba AN, Maajid S, Badoo AR, Mir GR: Osteoblastoma of body of the talus--Report of a rare case with atypical radiological features. Foot Ankle Surg; 2010 Jun;16(2):e24-6
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  • [Title] Osteoblastoma of body of the talus--Report of a rare case with atypical radiological features.
  • Osteoblastoma is a benign bone tumour found commonly in the spine and long tubular bones.
  • Osteoblastoma of the body of talus is a very rare entity.
  • Analysis of clinical, radiological and histological findings confirmed the diagnosis of osteoblastoma.
  • The case is reported for the rarity of the site and atypical radiological features that osteoblastoma can present with.
  • [MeSH-major] Bone Neoplasms / radiography. Osteoblastoma / radiography. Rare Diseases. Talus. Tomography, X-Ray Computed
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Osteotomy / methods

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  • [Copyright] Copyright 2009 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20483122.001).
  • [ISSN] 1460-9584
  • [Journal-full-title] Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons
  • [ISO-abbreviation] Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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12. Caufourier C, Leprovost N, Guillou-Jamard MR, Compère JF, Bénateau H: [Benign bone forming tumors]. Rev Stomatol Chir Maxillofac; 2009 Sep;110(4):202-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Benign bone forming tumors].
  • Benign bone forming tumors typically produce dense bone (osteoma, enostosis) or osteoid tissue (osteoid osteoma, osteoblastoma).
  • Even though these four lesions have distinct characteristics, it is sometimes difficult to tell them apart and to rule out malignant bone forming lesions such as osteosarcoma.
  • [MeSH-major] Facial Bones / pathology. Skull Neoplasms / diagnosis
  • [MeSH-minor] Adult. Child. Diagnosis, Differential. Exostoses / diagnosis. Fibrous Dysplasia of Bone / diagnosis. Humans. Osteoblastoma / diagnosis. Osteoma / diagnosis. Osteoma, Osteoid / diagnosis. Osteosarcoma / diagnosis

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  • (PMID = 19660772.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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13. Puri A, Agarwal MG, Shah M, Srinivas CH, Shukla PJ, Shrikhande SV, Jambhekar NA: Decision making in primary sacral tumors. Spine J; 2009 May;9(5):396-403
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  • The diagnosis included chordoma in six patients, giant cell tumor in seven patients, aneurysmal bone cyst in two patients, and a chondrosarcoma and an osteoblastoma in one patient each.
  • Six benign lesions were treated with curettage.
  • CONCLUSION: Wide resection with adequate margins gives the best chance of local control and should be the surgery of choice for all malignant primary sacral tumors and in benign lesions involving lower segments when preservation of both S3 roots is possible.
  • To retain bladder and bowel control and minimize neurological dysfunction, it may be worthwhile managing benign sacral tumors that extend above S3 with serial embolization.

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  • (PMID = 19059810.001).
  • [ISSN] 1878-1632
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Moon KS, Jung S, Lee JH, Jung TY, Kim IY, Kim SH, Kang SS: Benign osteoblastoma of the occipital bone: case report and literature review. Neuropathology; 2006 Apr;26(2):141-6
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  • [Title] Benign osteoblastoma of the occipital bone: case report and literature review.
  • We present a case of benign osteoblastoma of the occipital bone.
  • Benign osteoblastoma is an uncommon primary bone tumor, which usually involves the vertebrae and the long bones.
  • To the best of our knowledge, this case is only the eighth reported case of benign osteoblastoma confined to the occipital bone.
  • However, it was very difficult to formulate a differential diagnosis against other osteoblastic tumors, or osteoid osteoma, in view of its radiological appearance.
  • The final diagnosis was obtained by careful consideration of the histopathological characteristics of the tumor combined with its clinical and radiological features.
  • Although generally regarded as benign, a complete resection is preferred over conventional curettage as this can guard against possible recurrence and malignant transformation.
  • [MeSH-major] Occipital Bone / pathology. Osteoblastoma / pathology. Skull Neoplasms / pathology

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  • (PMID = 16708546.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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15. Tugcu B, Gunaldi O, Gunes M, Tanriverdi O, Bilgic B: Osteoblastoma of the temporal bone: a case report. Minim Invasive Neurosurg; 2008 Oct;51(5):310-2
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  • [Title] Osteoblastoma of the temporal bone: a case report.
  • Benign osteoblastoma is an unusual primary bone tumor.
  • Osteoblastoma affecting the calvarium is extremely rare.
  • Computed tomography revealed an expansile, lytic lesion in the left temporal bone.
  • T1- and T2-weighted magnetic resonance (MR) images demonstrated an isointense lesion in the temporal bone.
  • The histopathological findings proved that the lesion was a benign osteoblastoma.
  • To date, very few cases of the benign osteoblastoma arising in the calvarium have been reported in the literature.
  • [MeSH-major] Osteoblastoma / diagnosis. Skull Neoplasms / diagnosis. Temporal Bone
  • [MeSH-minor] Age of Onset. Craniotomy. Diagnosis, Differential. Gadolinium. Humans. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness. Neurosurgical Procedures. Predictive Value of Tests. Preoperative Care. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 18855299.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] AU0V1LM3JT / Gadolinium
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16. Tarantino R, Piccirilli M, Anichini G, Delfini R: Benign osteoblastoma of the odontoid process of the axis with secondary aneurysmal bone cyst component: a case report. Neurosurg Rev; 2008 Jan;31(1):111-5
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  • [Title] Benign osteoblastoma of the odontoid process of the axis with secondary aneurysmal bone cyst component: a case report.
  • The authors report their experience on one patient with osteoblatoma of the odontoid process of the axis with secondary aneurysmal bone cyst.
  • Because of the rarity of this lesion, it was difficult to have a certain preoperative diagnosis.
  • The intraoperative histological examination showed the benign nature of the lesion.
  • The histological examination revealed an osteoblastoma of the odontoid process of the axis with a secondary aneurysmal bone cyst.
  • [MeSH-major] Bone Cysts, Aneurysmal / complications. Odontoid Process. Osteoblastoma / complications. Spinal Neoplasms / complications

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  • [Cites] J Neurosurg. 1988 Dec;69(6):895-903 [3193195.001]
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  • (PMID = 17960438.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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17. Wootton-Gorges SL: MR imaging of primary bone tumors and tumor-like conditions in children. Magn Reson Imaging Clin N Am; 2009 Aug;17(3):469-87, vi
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  • [Title] MR imaging of primary bone tumors and tumor-like conditions in children.
  • This article provides a review of the MR imaging features of the major primary malignant and benign bone tumors and tumorlike conditions encountered in the pediatric population.
  • Benign lesions discussed include simple bone cysts, aneurysmal bone cysts, giant cell tumor, osteochondroma, enchondroma, chondroblastoma, osteoid osteoma, osteoblastoma, nonossifying fibroma, fibrous dysplasia, osteofibrous dysplasia, hemangioma, and histiocytosis.
  • The use of MR imaging in the diagnosis of these lesions is discussed, and the text is enhanced with imaging examples of the lesions.
  • [MeSH-major] Bone Neoplasms / diagnosis. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Adolescent. Bone Cysts / diagnosis. Bone Cysts / pathology. Cartilage Diseases / diagnosis. Cartilage Diseases / pathology. Child. Contrast Media. Humans

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  • (PMID = 19524197.001).
  • [ISSN] 1557-9786
  • [Journal-full-title] Magnetic resonance imaging clinics of North America
  • [ISO-abbreviation] Magn Reson Imaging Clin N Am
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 44
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18. Mirbagheri N, Galloway S, Iseli TA, Lyons BM: Extraosseous osteoblastoma of larynx presenting with acute airway obstruction. J Laryngol Otol; 2008 Nov;122(11):1265-8
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  • [Title] Extraosseous osteoblastoma of larynx presenting with acute airway obstruction.
  • OBJECTIVE: We report the case of an osteoblastoma of the larynx arising from the vocal fold, which presented with acute airway obstruction and cardiopulmonary arrest.
  • METHOD: The histopathological findings, differential diagnoses and a novel method of treating laryngeal osteoblastoma, using transoral laser therapy, are discussed.
  • RESULTS: Benign osteoblastoma is a rare primary bone tumour usually presenting in young patients in the spine and sacrum.
  • Once the diagnosis is confirmed, successful treatment is achieved with surgical excision.
  • CONCLUSION: Osteoblastoma of the larynx is rare, and the clinical features can vary with the anatomical site of the lesion.
  • [MeSH-major] Airway Obstruction / etiology. Laryngeal Neoplasms / complications. Osteoblastoma / complications
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Laser Therapy / methods. Male. Treatment Outcome

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  • (PMID = 18289457.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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19. Gomez-Brouchet A, Mourcin F, Gourraud PA, Bouvier C, De Pinieux G, Le Guelec S, Brousset P, Delisle MB, Schiff C: Galectin-1 is a powerful marker to distinguish chondroblastic osteosarcoma and conventional chondrosarcoma. Hum Pathol; 2010 Sep;41(9):1220-30
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  • The clinical management of osteosarcoma differs significantly from that of chondrosarcoma; therefore, it is extremely important to diagnose these 2 types of bone tumor accurately.
  • In the absence of a specific marker, differential diagnosis by histochemistry is sometimes impossible, especially between chondroblastic osteosarcoma and conventional chondrosarcoma.
  • We analyzed 165 bone sarcomas by immunohistochemical staining of tissue microarrays for expression of the galectin-1 (GAL1) lectin and by Western blot experiments.
  • We found that GAL1 was abundant in normal human osteoblasts from benign proliferations and in osteosarcomas, including chondroblastic osteosarcomas, but not in chondrosarcomas.
  • We propose a diagnostic test for bone tumors that takes into account the optimal discriminative values for the percentage of cells stained and the intensity of staining.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Bone Neoplasms / diagnosis. Chondrosarcoma / diagnosis. Galectin 1 / metabolism. Osteosarcoma / diagnosis
  • [MeSH-minor] Adolescent. Blotting, Western. Cell Count. Chondrocytes / metabolism. Chondrocytes / pathology. Diagnosis, Differential. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Osteoblastoma / metabolism. Osteoblastoma / pathology. Periostitis / metabolism. Periostitis / pathology. Tissue Array Analysis


20. Mahajan S, Srikant N, Boaz K, George T: Osteoblastoma of maxilla with cartilaginous matrix: review of literature and report of a case. Singapore Dent J; 2007 Dec;29(1):12-8
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  • [Title] Osteoblastoma of maxilla with cartilaginous matrix: review of literature and report of a case.
  • Osteoblastoma is a rare benign neoplasm of jaws.
  • We report a case of a recurrent osteoblastoma in the maxilla of a 34-year-old male who presented with aggressive clinical and histologic features: namely root resorption, tooth mobility, involvement of maxillary sinus, chondroid formation, host bone trapping, and lack of osteoblastic rimming.
  • A systematic review of other reported cases of osteoblastoma of jaws with a note on the recurrent cases has been put forth.
  • [MeSH-major] Cartilage / pathology. Maxillary Neoplasms / pathology. Osteoblastoma / pathology
  • [MeSH-minor] Adult. Connective Tissue / pathology. Diagnosis, Differential. Humans. Male. Maxillary Sinus / pathology. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Osteoblasts / pathology

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  • (PMID = 18472525.001).
  • [ISSN] 0377-5291
  • [Journal-full-title] Singapore dental journal
  • [ISO-abbreviation] Singapore Dent J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Singapore
  • [Number-of-references] 18
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21. Arkader A, Dormans JP: Osteoblastoma in the skeletally immature. J Pediatr Orthop; 2008 Jul-Aug;28(5):555-60
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  • [Title] Osteoblastoma in the skeletally immature.
  • BACKGROUND: Osteoblastoma is a rare benign and sometimes locally aggressive tumor with peak incidence in the second decade.
  • METHODS: The medical records and radiographs of all children diagnosed with osteoblastoma during a 17-year period were reviewed.
  • We recorded demographic information, time until diagnosis, location, clinical and radiographic characteristics, treatment, complications, and outcome at a minimum 2-year follow-up (range, 2-5 years).
  • There were 10 boys and 7 girls, with an average age at diagnosis of 11 years (range, 20 months-15 years).
  • The average time delay between onset of symptoms and diagnosis was 6.5 months (range, 2 months-2 years).
  • [MeSH-major] Bone Neoplasms / therapy. Osteoblastoma / therapy

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  • (PMID = 18580372.001).
  • [ISSN] 0271-6798
  • [Journal-full-title] Journal of pediatric orthopedics
  • [ISO-abbreviation] J Pediatr Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Yang JZ, Zhang XH, Liu JR, Ding Y, Gao F, Wang Y: [Expression and significance of N-cadherin and β-catenin protein in osteosarcoma]. Zhonghua Zhong Liu Za Zhi; 2010 Aug;32(8):586-9
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  • METHODS: The expressions of N-cadherin and β-catenin at protein level were detected by immunohistochemical staining in 54 cases of osteosarcoma, 11 cases of osteoid osteoma, 7 cases of osteoblastoma and 8 cases of newly formed bone in nonmalignant bone diseases.
  • RESULTS: In newly formed bone, osteoblastoma, osteoid osteoma and osteosarcoma, the positive expression rate of N-cadherin protein was 75.0%, 71.4%, 63.6% and 35.2%, respectively.
  • The positive expression rate of N-cadherin protein in osteosarcoma was significantly lower than that in osteoid osteoma, osteoblastoma and newly formed bone in nonmalignant bone diseases (P = 0.035).
  • In newly formed bone, osteoblastoma, osteoid osteoma and osteosarcoma, the aberrant expression rate of β-catenin protein was 12.5%, 28.6%, 27.3% and 66.7%, respectively.
  • The aberrant expression rate of β-catenin protein in osteosarcoma was significantly higher than that in osteoid osteoma, osteoblastoma and newly formed bone (P = 0.002).
  • [MeSH-major] Bone Neoplasms / metabolism. Cadherins / metabolism. Lung Neoplasms / metabolism. Osteosarcoma / metabolism. beta Catenin / metabolism
  • [MeSH-minor] Adolescent. Adult. Child. Female. Follow-Up Studies. Humans. Male. Middle Aged. Osteoblastoma / metabolism. Osteoma, Osteoid / metabolism. Survival Rate. Young Adult


23. O'Dwyer HM, Keogh CF, O'Connell JX, Munk PL: A case report of synchronous osteoblastoma and fibromatosis. Br J Radiol; 2008 Mar;81(963):e68-71
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  • [Title] A case report of synchronous osteoblastoma and fibromatosis.
  • Osteoblastoma is a rare bone tumour that accounts for 1% of all primary bone tumours and 3% of all benign bone tumours.
  • Osteoblastoma occurring in long bones has a predilection for the meta-diaphysis.
  • It bears a close histological resemblance to osteoid osteoma, but it is not growth limited - usually 2 cm or greater at diagnosis.
  • The term "fibromatosis" covers a broad spectrum of benign fibrous tissue proliferations.
  • To our knowledge, this is the first case report in the English literature of a patient with synchronous presentation of an osteoblastoma and fibromatosis.
  • [MeSH-major] Femoral Neoplasms / pathology. Fibroma / pathology. Neoplasms, Multiple Primary / pathology. Osteoblastoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Thigh. Tomography, X-Ray Computed

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  • (PMID = 18270286.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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24. Lee YG, Cho CW: Benign osteoblastoma located in the parietal bone. J Korean Neurosurg Soc; 2010 Aug;48(2):170-2
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  • [Title] Benign osteoblastoma located in the parietal bone.
  • Benign osteoblastoma is an uncommon primary bone tumor, extremely rare in calvarium.
  • We present a case of a 25-year-old female with an osteoblastoma of parietal bone which was totally resected.
  • The authors discussed the clinical presentation, radiographic finding, differential diagnosis and management of the benign calvarial osteoblastoma with a review of the literature.

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  • (PMID = 20856669.001).
  • [ISSN] 1598-7876
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2941863
  • [Keywords] NOTNLM ; Osteoblastoma / Parietal bone
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25. Folk GS, Williams SB, Foss RB, Fanburg-Smith JC: Oral and maxillofacial sclerosing epithelioid fibrosarcoma: report of five cases. Head Neck Pathol; 2007 Sep;1(1):13-20
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  • Tumor location included the infra-temporal fossa, buccal mucosa (recurrence extending into bone), anterior mandible (intraosseous primary, focally extending into soft tissue), and left parotid and submandibular gland (with metaplastic bone) regions.
  • OMFRSEF occur in adults in various locations, but with a common propensity to involve bone; there is recurrent potential and morbidity with higher grade lesions.
  • The differential diagnosis for these tumors in this site includes sclerosing carcinoma, Ewing/PNET, osteosarcoma, osteoblastoma, and benign and malignant myoepithelial salivary gland tumors.
  • [MeSH-minor] Adult. Apoptosis. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Leiomyoma / diagnosis. Male. Middle Aged. Sclerosis. Solitary Fibrous Tumors / diagnosis. Young Adult

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  • (PMID = 20614275.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807507
  • [Keywords] NOTNLM ; Maxillofacial / Oral / Sarcoma / Sclerosing epithelioid fibrosarcoma
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26. Kaya A, Altay T, Sezak M, Ozturk H: Periosteal osteoblastoma of the distal femur. Acta Orthop Belg; 2009 Apr;75(2):280-5
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  • [Title] Periosteal osteoblastoma of the distal femur.
  • Periosteal osteoblastoma is a rare benign osteoblastic bone tumour located on the cortical bone.
  • We report a case of periosteal osteoblastoma located at the distal femur in a 31-year-old man.
  • Clinical, radiological and histopathologic findings are described and differential diagnosis is discussed.
  • Despite its rarity, periosteal osteoblastoma should be considered as a possible diagnosis together with periostitis ossificans, periosteal chondroma, periosteal osteosarcoma and parosteal osteosarcoma when confronted with a superficial bone lesion.
  • [MeSH-major] Femoral Neoplasms / diagnosis. Osteoblastoma / diagnosis. Periosteum
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 19492573.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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27. Capodiferro S, Maiorano E, Giardina C, Lacaita MG, Lo Muzio L, Favia G: Osteoblastoma of the mandible: clinicopathologic study of four cases and literature review. Head Neck; 2005 Jul;27(7):616-21
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  • [Title] Osteoblastoma of the mandible: clinicopathologic study of four cases and literature review.
  • BACKGROUND: Osteoblastoma is a benign bone tumor accounting for 1% of all bone tumors; it commonly involves the spine and the sacrum of young individuals, with less than 5% being localized to the posterior mandible.
  • In view of its rarity in the maxilla and mandible, osteoblastoma is rarely diagnosed as such in the absence of interdisciplinary cooperation.
  • METHODS: A retrospective study of four benign osteoblastomas was performed based on a review of the clinical, radiographic, and histopathologic features of all cases.
  • RESULTS: The tumors involved the posterior mandible of young patients (age range, 10-21 years; two male and two female patients) and appeared as painful bone expansions.
  • Histologically, they were composed of osteoid and woven bone surrounded by plump osteoblast-like cells with interposed fibroblasts, inflammatory cells, and red blood cells.
  • CONCLUSIONS: Osteoblastomas may be distinguished from other bone tumors, fibro-osseous lesions, and odontogenic neoplasms on the basis of integrated clinical, radiologic, and histologic features and usually manifest an indolent clinical course.
  • [MeSH-major] Mandibular Neoplasms / pathology. Osteoblastoma / pathology
  • [MeSH-minor] Adolescent. Adult. Child. Diagnosis, Differential. Female. Humans. Male. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 15880408.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 20
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28. Svoboda M, Hamilton G, Thalhammer T: Steroid hormone metabolizing enzymes in benign and malignant human bone tumors. Expert Opin Drug Metab Toxicol; 2010 Apr;6(4):427-37
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  • [Title] Steroid hormone metabolizing enzymes in benign and malignant human bone tumors.
  • IMPORTANCE IN THE FIELD: Primary bone tumors are considered as (sex steroid) hormone-dependent tumors.
  • Osteosarcoma, osteoblastoma and bone cysts are preferentially found in males, while giant cell tumors are more common in females.
  • Indeed, bone tumor development and progression are influenced by sex steroid hormones derived from in situ synthesis in bone cells.
  • An overview is given and the expression and function of these enzymes in bone tumors are discussed.
  • TAKE HOME MESSAGE: Knowledge on pathways for the in situ formation of E2 in bone cells may allow the identification of potential targets for i) novel endocrine therapeutic options in primary bone tumors and ii) future preventive interventions.
  • [MeSH-major] Bone Neoplasms / enzymology. Bone Neoplasms / pathology. Bone and Bones / cytology. Bone and Bones / enzymology. Gonadal Steroid Hormones / metabolism

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  • (PMID = 20102288.001).
  • [ISSN] 1744-7607
  • [Journal-full-title] Expert opinion on drug metabolism & toxicology
  • [ISO-abbreviation] Expert Opin Drug Metab Toxicol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Gonadal Steroid Hormones; 4TI98Z838E / Estradiol
  • [Number-of-references] 89
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29. Manjunatha BS, Nagarajappa D: Osteoid osteoma. Indian J Dent Res; 2009 Oct-Dec;20(4):514-5
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  • Osteoid osteoma is a benign tumor of the bone which arises from osteoblasts and is extremely rare in jaws.
  • [MeSH-major] Mandibular Neoplasms / diagnosis. Osteoma, Osteoid / diagnosis
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Female. Fibroma, Ossifying / diagnosis. Humans. Mandibular Diseases / diagnosis. Osteitis / diagnosis. Osteoblastoma / diagnosis

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  • (PMID = 20139585.001).
  • [ISSN] 1998-3603
  • [Journal-full-title] Indian journal of dental research : official publication of Indian Society for Dental Research
  • [ISO-abbreviation] Indian J Dent Res
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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30. Van Dyck P, Vanhoenacker FM, Vogel J, Venstermans C, Kroon HM, Gielen J, Parizel PM, Bloem JL, De Schepper AM: Prevalence, extension and characteristics of fluid-fluid levels in bone and soft tissue tumors. Eur Radiol; 2006 Dec;16(12):2644-51
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  • [Title] Prevalence, extension and characteristics of fluid-fluid levels in bone and soft tissue tumors.
  • The purpose of this study was to determine the prevalence, extension and signal characteristics of fluid-fluid levels in a large series of 700 bone and 700 soft tissue tumors.
  • Out of a multi-institutional database, MRI of 700 consecutive patients with a bone tumor and MRI of 700 consecutive patients with a soft tissue neoplasm were retrospectively reviewed for the presence of fluid-fluid levels.
  • Of 700 patients with a bone tumor, 19 (10 male and 9 female; mean age, 29 years) presented with a fluid-fluid level (prevalence 2.7%).
  • Diagnoses included aneurysmal bone cyst (ten cases), fibrous dysplasia (two cases), osteoblastoma (one case), simple bone cyst (one case), telangiectatic osteosarcoma (one case), "brown tumor" (one case), chondroblastoma (one case) and giant cell tumor (two cases).
  • Diagnoses included cavernous hemangioma (12 cases), synovial sarcoma (3 cases), angiosarcoma (1 case), aneurysmal bone cyst of soft tissue (1 case), myxofibrosarcoma (1 case) and high-grade sarcoma "not otherwise specified" (2 cases).
  • In our series, the largest reported in the literature to the best of our knowledge, the presence of fluid-fluid levels is a rare finding with a prevalence of 2.7 and 2.9% in bone and soft tissue tumors, respectively.
  • Fluid-fluid levels remain a non-specific finding and can occur in a wide range of bone and soft tissue tumors, both benign and malignant.
  • Therefore, they cannot be considered diagnostic of any particular type of tumor, and the diagnosis should be made on the basis of other radiological and clinical findings.
  • [MeSH-major] Body Fluids / metabolism. Bone Neoplasms / pathology. Magnetic Resonance Imaging / methods. Soft Tissue Neoplasms / pathology

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  • (PMID = 16612549.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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31. Alvares Capelozza AL, Gião Dezotti MS, Casati Alvares L, Negrão Fleury R, Sant'Ana E: Osteoblastoma of the mandible: systematic review of the literature and report of a case. Dentomaxillofac Radiol; 2005 Jan;34(1):1-8
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  • [Title] Osteoblastoma of the mandible: systematic review of the literature and report of a case.
  • Benign osteoblastoma is a bone tumour that seldom occurs in the facial bones.
  • A new case of benign osteoblastoma is presented and clinical, radiographic and microscopic aspects, as well as differential diagnosis, treatment and follow-up are discussed.
  • The importance of the correct diagnosis of this type of lesion is stressed, since it presents a clinical, radiographic and microscopic similarity to other bone lesions, including malignant tumours, which may lead the professional into conducting the case in an improper manner.
  • [MeSH-major] Mandibular Neoplasms / radiography. Osteoblastoma / radiography
  • [MeSH-minor] Child. Diagnosis, Differential. Humans. Male

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  • (PMID = 15709098.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 69
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32. Tamiolakis D, Thomaidis V, Tsamis I, Alexiadis G, Seretis K: Clinical, radiological and histological correlation in the diagnostic work-up of cemento-ossifying fibroma of the maxilla: case report. Chirurgia (Bucur); 2007 May-Jun;102(3):359-62
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  • This lesion appears within the bone although in some occasions it involves the gingivae soft tissues.
  • It is a slow growing and well-defined tumorous lesion, because of this, it is considered as a benign lesion.
  • The histology was that of a benign fibro-osseous proliferation composed of bony spicules and spherules admixed with a fibrous stroma.
  • Clinical and radiological information was essential for the final diagnosis.
  • The histologic findings alone may be similar to other pathologies such as osteoblastoma, low-grade osteosarcoma and particularly to fibrous dysplasia.
  • An accurate diagnosis requires careful clinical, radiological and histological correlation in order to make an optimal treatment and an excellent outcome.
  • [MeSH-major] Fibroma, Ossifying / diagnosis. Maxillary Neoplasms / diagnosis

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  • (PMID = 17687869.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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33. Angiero F, Mellone P, Baldi A, Stefani M: Osteoblastoma of the jaw: report of two cases and review of the literature. In Vivo; 2006 Sep-Oct;20(5):665-70
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  • [Title] Osteoblastoma of the jaw: report of two cases and review of the literature.
  • Osteoblastoma is a benign bone tumor of osteoblastic origin.
  • Differential diagnosis and immunohistochemical features potentially useful for refining diagnosis of osteoblastoma are also discussed.
  • [MeSH-major] Biomarkers, Tumor / analysis. Jaw Neoplasms / pathology. Osteoblastoma / pathology

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  • (PMID = 17091775.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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34. Dellmann A, Schroeder HG, Donhuijsen K: Destructive tumours of the larynx mimicking osteosarcoma: two cases of osteoblastoma with organ-saving resection and follow-up. Eur Arch Otorhinolaryngol; 2010 Jan;267(1):151-4
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  • [Title] Destructive tumours of the larynx mimicking osteosarcoma: two cases of osteoblastoma with organ-saving resection and follow-up.
  • Osteoblastoma of the larynx is an extremely rare type of locally progressive and destructive tumour which is mimicking osteosarcoma radiologically and histologically.
  • Since prognostic and therapeutic strategies for benign osteoblastoma differ from the more common osteosarcoma of the larynx, a meticulous pre-operative histological diagnosis is required to avoid over-therapy.
  • We report about two patients with osteoblastoma of the larynx with organ-saving resection and long-period follow-up without tumour recurrence.
  • This situation is quite different from the usual osteoblastomas of bone, which occur in young adults of both sexes equally.
  • [MeSH-major] Laryngeal Neoplasms / surgery. Laryngectomy / methods. Osteoblastoma / surgery. Osteosarcoma / diagnosis
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Follow-Up Studies. Humans. Laryngoscopy. Male. Tomography, X-Ray Computed

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  • (PMID = 19760213.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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35. Gdoura F, Trigui M, Ellouze Z, Hamed YB, Ayadi K, Keskes H: Hamatum osteoblastoma. Orthop Traumatol Surg Res; 2010 Oct;96(6):712-6
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  • [Title] Hamatum osteoblastoma.
  • We report the case of an osteoblastoma of the hamate bone that was successfully treated by curettage.
  • This tumor is very rare in a carpal bone and only nine cases have been reported in the literature.
  • Osteoblastomas are benign, but potentially aggressive bone tumors.
  • [MeSH-major] Bone Neoplasms / surgery. Hamate Bone / surgery. Osteoblastoma / surgery
  • [MeSH-minor] Adult. Biopsy. Bone Cysts / diagnosis. Bone Cysts / pathology. Bone Cysts / surgery. Curettage. Delayed Diagnosis. Humans. Magnetic Resonance Imaging. Male. Osteolysis / diagnosis. Osteolysis / pathology. Osteolysis / surgery

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20692218.001).
  • [ISSN] 1877-0568
  • [Journal-full-title] Orthopaedics & traumatology, surgery & research : OTSR
  • [ISO-abbreviation] Orthop Traumatol Surg Res
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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36. Gibson SE, Prayson RA: Primary skull lesions in the pediatric population: a 25-year experience. Arch Pathol Lab Med; 2007 May;131(5):761-6
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  • The differential diagnosis of these lesions is broad and includes both congenital and acquired lesions.
  • RESULTS: Nineteen primary skull lesions were identified in 11 male (58%) and 8 female (42%) patients, with a median age at diagnosis of 9.5 years.
  • These lesions were usually benign and most commonly presented as a painless mass (n = 8).
  • The lesions were located in the occipital bone (n = 7), frontal bone (n = 5), parietal bone (n = 2), and temporal bone (n = 1).
  • Diagnoses included epidermoid/dermoid cyst (n = 8), Langerhans cell histiocytosis (n = 6), intraosseous hemangioma (n = 2), osteoblastoma (n = 1), infantile myofibroma (n = 1), and fibroma (n = 1).
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Infant, Newborn. Male. Retrospective Studies

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  • (PMID = 17488162.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Saccomanni B: Osteoid osteoma and osteoblastoma of the spine: a review of the literature. Curr Rev Musculoskelet Med; 2009 Mar;2(1):65-7
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  • [Title] Osteoid osteoma and osteoblastoma of the spine: a review of the literature.
  • Osteoid osteoma and osteoblastoma are rare primary bone tumors that usually do not arise in the spine.
  • Histologically, osteoid osteoma and osteoblastoma are similar, containing osteoblasts that produce osteoid and woven bone.
  • Osteoblastoma, however, is larger, tends to be more aggressive, and can undergo malignant transformation, whereas osteoid osteoma is small, benign, and self-limited.
  • With the help of modern imaging modalities that aid in diagnosis and surgical planning, a complete removal and cure may be achieved for most of these rare tumors.

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  • (PMID = 19468920.001).
  • [ISSN] 1935-973X
  • [Journal-full-title] Current reviews in musculoskeletal medicine
  • [ISO-abbreviation] Curr Rev Musculoskelet Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Chakrapani SD, Grim K, Kaimaktchiev V, Anderson JC: Osteoblastoma of the spine with discordant magnetic resonance imaging and computed tomography imaging features in a child. Spine (Phila Pa 1976); 2008 Dec 1;33(25):E968-70
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  • [Title] Osteoblastoma of the spine with discordant magnetic resonance imaging and computed tomography imaging features in a child.
  • OBJECTIVE: To describe the magnetic resonance imaging (MRI) and computed tomography (CT) findings of spinal osteoblastoma and illustrate how MRI features can be potentially misleading.
  • SUMMARY OF BACKGROUND DATA: Osteoblastoma is a rare benign tumor of bone that is known to incite a localized inflammatory response.
  • These inflammatory features can simulate malignant behavior on MRI and can lead to misdiagnosis and unnecessarily aggressive resection unless one recognizes the classic benign features on CT.
  • We present a case of osteoblastoma in a child to illustrate this concept.
  • A CT demonstrates a well-circumscribed lesion without lytic changes or malignant bone formation.
  • A benign lesion was favored given the CT features and conservative resection was performed.
  • Final pathologic diagnosis was osteoblastoma.
  • CONCLUSION: This case illustrates that the MRI findings for osteoblastoma can be misleading and caution should be used when evaluating benign tumors with known inflammatory responses on MRI.
  • [MeSH-major] Magnetic Resonance Imaging. Osteoblastoma / diagnosis. Spinal Neoplasms / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Humans. Inflammation / diagnosis. Inflammation / radiography. Inflammation / surgery. Lumbar Vertebrae / pathology. Lumbar Vertebrae / radiography. Lumbar Vertebrae / surgery

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  • (PMID = 19050575.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Chadha M, Agarwal A, Wadhwa N: Chondroid chordoma of the L5 spinous process and lamina: a case report. Eur Spine J; 2005 Oct;14(8):803-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chordoma is a rare bone tumor that originates from the remnants of the notochord.
  • A differential diagnosis of a benign tumor (giant cell tumor, aneurysmal bone cyst or osteoblastoma) was made initially.
  • [MeSH-major] Chordoma / pathology. Diagnosis, Differential. Lumbar Vertebrae / pathology

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  • (PMID = 15895260.001).
  • [ISSN] 0940-6719
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
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40. Shintaku WH, Venturin JS, Langlais RP, Clark GT: Imaging modalities to access bony tumors and hyperplasic reactions of the temporomandibular joint. J Oral Maxillofac Surg; 2010 Aug;68(8):1911-21
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  • Benign and malignant tumors in the temporomandibular joint (TMJ) are rare.
  • The differential diagnosis for benign hyperplastic bony lesions in the TMJ should include condylar hyperplasia, osteochondroma, osteoma, chondroma, and osteoblastoma.
  • For the differential diagnosis, imaging is the most noninvasive method to evaluate the integrity of the TMJ.
  • To differentiate benign and malignant bony tumors, magnetic resonance imaging has a sensitivity and specificity of 44% and 95%, respectively.
  • [MeSH-major] Bone Neoplasms / diagnosis. Diagnostic Imaging / methods. Head and Neck Neoplasms / diagnosis. Temporomandibular Joint Disorders / diagnosis
  • [MeSH-minor] Cone-Beam Computed Tomography. Humans. Hyperplasia / diagnosis. Magnetic Resonance Imaging. Positron-Emission Tomography. Radiography, Panoramic. Sensitivity and Specificity. Temporomandibular Joint / pathology. Temporomandibular Joint / radiography. Temporomandibular Joint / radionuclide imaging. Tomography, Emission-Computed, Single-Photon. Tomography, X-Ray Computed


41. Herrera Tenorio JG, Núnuez Fernández AI, Mendoza Quiroga JJ, Sesma Villalpando RA: [Benign osteoblastoma in the proximal phalanx. A case report]. Acta Ortop Mex; 2009 Sep-Oct;23(5):298-301
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  • [Title] [Benign osteoblastoma in the proximal phalanx. A case report].
  • [Transliterated title] Osteoblastoma benigno en falange proximal. Reporte de un caso.
  • The purpose of this article is to present a case of phalanx osteoblastoma.
  • We will start by saying that osteoblastoma is rare, it accounts for 1% of primary bone tumors; it is most frequent in the posterior spine, and is very unusual in the phalanges.
  • Early diagnosis is desirable due to its similarity, mainly radiologic, with other entities that result in similar bone lesions.
  • [MeSH-major] Bone Neoplasms. Finger Phalanges. Osteoblastoma

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  • (PMID = 20336881.001).
  • [ISSN] 2306-4102
  • [Journal-full-title] Acta ortopédica mexicana
  • [ISO-abbreviation] Acta Ortop Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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42. Karantanas A, Dailiana Z, Malizos K: The role of MR imaging in scaphoid disorders. Eur Radiol; 2007 Nov;17(11):2860-71
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  • The scaphoid bone of the wrist is one of the most commonly fractured bones in the body.
  • In patients with normal initial plain radiographs, MR imaging can discriminate occult fractures from bone bruises and may also demonstrate ligamentous disruption.
  • The non-traumatic disorders of the scaphoid include post-traumatic osteoarthritis, inflammatory bone marrow edema in patients with rheumatoid arthritis, and osteomyelitis.
  • MR imaging is helpful in all the above disorders to demonstrate early bone marrow edema, cartilage degeneration and associated subchondral marrow changes.
  • The most commonly found tumors in the scaphoid are usually benign and include enchondroma, osteoblastoma and osteoid osteoma.
  • MR imaging is not mandatory for the initial diagnosis, which should be based on plain X-ray findings.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Musculoskeletal Diseases / diagnosis. Musculoskeletal Diseases / diagnostic imaging. Scaphoid Bone / diagnostic imaging. Scaphoid Bone / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomechanical Phenomena / methods. Bone and Bones / metabolism. Female. Fracture Healing. Humans. Male. Middle Aged. Osteonecrosis. Radionuclide Imaging / methods. Time Factors. Tomography, X-Ray Computed / methods

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  • (PMID = 17351778.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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43. Kaplan I, Nicolaou Z, Hatuel D, Calderon S: Solitary central osteoma of the jaws: a diagnostic dilemma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Sep;106(3):e22-9
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  • Osteomas are relatively rare benign osteogenic neoplasms, characterized by the proliferation of compact and/or cancellous bone.
  • Osteomas can develop as peripheral (periosteal) masses attached to the cortical plates or as central lesions arising from endosteal bone surfaces.
  • Whereas peripheral osteomas are fairly easy to diagnose, central osteomas pose a more challenging diagnostic problem and need to be differentiated from other similar lesions of the jaws, such as central ossifying fibroma, condensing osteitis, idiopathic osteosclerosis, osteoblastoma, cementoblastoma, and complex odontoma.
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 18602294.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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44. Pérez-Mora RM, Sanchez-Carrion S, Barea FL, Garcia-Raya P, Lassaletta L: Osteoblastoma of the temporal bone. Skull Base; 2009 Sep;19(5):345-8
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  • [Title] Osteoblastoma of the temporal bone.
  • Benign osteoblastoma is an uncommon primary tumor of the bone.
  • Any area of the skeleton may be affected by this tumor, but its occurrence in the temporal bone and middle ear is extremely rare.
  • Clinical symptoms are nonspecific, even in the middle ear, and the diagnosis is often difficult in spite a complete physical and radiological examination.
  • A biopsy is usually necessary for definitive diagnosis.
  • Because of its potential for recurrence, local invasion, and, rarely, malignant transformation, a complete surgical excision remains the treatment of choice for osteoblastoma.
  • We report a case of benign osteoblastoma involving the temporal bone and the middle ear and a review of the literature.

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  • (PMID = 20190944.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2765705
  • [Keywords] NOTNLM ; Osteoblastoma / hearing loss / temporal bone / tinnitus
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45. Bhagat S, Sharma H, Bansal M, Reid R: Presentation and outcome of primary tumors of the patella. J Knee Surg; 2008 Jul;21(3):212-6
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  • One patient with chondroblastoma underwent curettage only; the second patient underwent curettage and bone grafting.
  • Patients with osteoblastoma and osteitis fibrosa cystica underwent excision of the lesion.
  • A satisfactory outcome can be expected in the majority because of the predominantly benign nature of the lesions and straightforward operative intervention after diagnosis.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Patella

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  • (PMID = 18686483.001).
  • [ISSN] 1538-8506
  • [Journal-full-title] The journal of knee surgery
  • [ISO-abbreviation] J Knee Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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46. Khin YT, Peh WC, Lee VK, Teo HE, Ng SB, Nathan SS: Aggressive osteoblastoma of the proximal humerus. Singapore Med J; 2009 Jan;50(1):e1-4
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  • [Title] Aggressive osteoblastoma of the proximal humerus.
  • Bone scintiscan showed solitary marked uptake.
  • The final diagnosis was osteoblastoma with aggressive features.
  • Osteoblastoma is a relatively rare benign tumour that typically occurs in the posterior elements of the vertebral column.
  • [MeSH-major] Bone Neoplasms / diagnosis. Humerus. Osteoblastoma / diagnosis
  • [MeSH-minor] Child. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Tomography, Emission-Computed

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  • (PMID = 19224061.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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47. Papadaki ME, Troulis MJ, Kaban LB: Advances in diagnosis and management of fibro-osseous lesions. Oral Maxillofac Surg Clin North Am; 2005 Nov;17(4):415-34
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  • [Title] Advances in diagnosis and management of fibro-osseous lesions.
  • Fibro-osseous lesions are benign mesenchymal skeletal tumors in which mineralized tissue, blood vessels, and giant cells in varying proportions replace normal bone.
  • Included in this group are fibrous dysplasia, cherubism, ossifying fibromas, and osteoblastoma, with fibrous dysplasia being the most common entity.
  • The purpose of this article is to describe advances in diagnosis and management of fibro-osseous lesions.

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  • (PMID = 18088796.001).
  • [ISSN] 1042-3699
  • [Journal-full-title] Oral and maxillofacial surgery clinics of North America
  • [ISO-abbreviation] Oral Maxillofac Surg Clin North Am
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Ugur HC, Torun F, Kanpolat Y: Petrous bone osteoblastoma invading the cavernous sinus. J Clin Neurosci; 2005 May;12(4):489-92
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  • [Title] Petrous bone osteoblastoma invading the cavernous sinus.
  • A CT scan revealed a mass originating from the petrous part of the temporal bone with infiltration of the cavernous sinus.
  • Pathological examination revealed benign osteoblastoma.
  • [MeSH-major] Bone Neoplasms / pathology. Cavernous Sinus / pathology. Osteoblastoma / pathology. Petrous Bone / pathology

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  • (PMID = 15925793.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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49. Njim L, Dhouibi A, Touil N, Lahmar I, Hadhri R, Moussa A, Zakhama A: Benign osteoblastoma in an unusual mastoid location. Eur Ann Otorhinolaryngol Head Neck Dis; 2010 Nov;127(5):183-5
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  • [Title] Benign osteoblastoma in an unusual mastoid location.
  • INTRODUCTION: Benign osteoblastoma (OB) is an unusual primary bone tumor.
  • We report herein an extremely rare location of an OB in the mastoid process of the temporal bone.
  • The pathologic examination of bone curettage material revealed a benign OB.
  • DISCUSSION/CONCLUSION: To our knowledge, this is the 14th reported case of OB confined to the mastoid process of temporal bone.
  • Its histological diagnosis can be difficult and osteosarcoma is its principal differential diagnosis.
  • Although generally regarded as benign, OB has potential for recurrence and local invasion.
  • [MeSH-major] Bone Neoplasms / diagnosis. Mastoid. Osteoblastoma / diagnosis

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20951662.001).
  • [ISSN] 1879-730X
  • [Journal-full-title] European annals of otorhinolaryngology, head and neck diseases
  • [ISO-abbreviation] Eur Ann Otorhinolaryngol Head Neck Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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50. Lucas DR: Osteoblastoma. Arch Pathol Lab Med; 2010 Oct;134(10):1460-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osteoblastoma.
  • Osteoblastoma is a rare benign bone tumor.
  • Although the histologic features in most cases are distinctive, there are various permutations that make the diagnosis challenging.
  • It can mimic a variety of other benign bone tumors, but more importantly, distinguishing it from osteoblastoma-like osteosarcoma can be difficult.
  • In this case report, I describe the clinicopathologic findings for a 13-year-old adolescent boy with T7 spinal osteoblastoma and review salient clinical, radiographic, and pathologic features of osteoblastoma, as well as the differential diagnoses.
  • [MeSH-major] Bone Neoplasms / pathology. Osteoblastoma / pathology. Spinal Neoplasms / pathology
  • [MeSH-minor] Adolescent. Cartilage, Articular / pathology. Cartilage, Articular / radiography. Diagnosis, Differential. Humans. Male. Osteoblasts / pathology. Osteoblasts / radiography. Osteoclasts / pathology. Osteoclasts / radiography. Tomography, X-Ray Computed

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  • (PMID = 20923301.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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51. Roessner A: [Bone tumors]. Verh Dtsch Ges Pathol; 2007;91:83-6
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  • [Title] [Bone tumors].
  • The primary round cell tumors of the skeletal system focus on the differential diagnosis of Ewing sarcoma.
  • Therefore, in most cases, the differential diagnosis to other "round cell" tumors of the skeletal system no longer causes great problems.
  • Besides the differential diagnosis of chondrogenic tumors, the diagnosis of osteoid-forming tumors is very problematic histologically.
  • Focus of attention is the diagnosis of highly malignant osteosarcoma.
  • This must be differentiated from the low malignant, intramedullary osteosarcomas, as well as from benign, osteoid-forming tumors and -like tumors.
  • Especially the tumors located at the border between highly malignant osteosarcoma and benign osteoblastoma are difficult as far as the differential diagnosis is concerned.
  • [MeSH-major] Bone Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Fibrous Dysplasia of Bone / pathology. Humans. Translocation, Genetic

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  • (PMID = 18314599.001).
  • [ISSN] 0070-4113
  • [Journal-full-title] Verhandlungen der Deutschen Gesellschaft für Pathologie
  • [ISO-abbreviation] Verh Dtsch Ges Pathol
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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52. von Chamier G, Holl-Wieden A, Stenzel M, Raab P, Darge K, Girschick HJ, Beer M: Pitfalls in diagnostics of hip pain: osteoid osteoma and osteoblastoma. Rheumatol Int; 2010 Jan;30(3):395-400
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pitfalls in diagnostics of hip pain: osteoid osteoma and osteoblastoma.
  • Osteoid osteoma and osteoblastoma are benign bone tumors that occur most often in adolescents and predominantly in males.
  • Typical clinical symptoms, such as reduced range of motion of adjacent joints, nocturnal bone pain and relief of pain using non-steroidal anti-inflammatory drug therapy especially in osteoid osteoma may lead to the correct diagnosis.
  • In radiographic examinations, the initial changes are often uncharacteristic causing further delay in diagnosis.
  • Magnetic resonance imaging is increasingly used for screening, but early findings in the course of disease might not lead to the definite diagnosis.
  • To demonstrate pitfalls in the diagnostic pathway of hip pain caused by benign bone tumors, we present two cases with osteoid osteoma and one with osteoblastoma.
  • [MeSH-major] Arthralgia / etiology. Bone Neoplasms / pathology. Diagnostic Errors / prevention & control. Hip Joint / pathology. Osteoblastoma / pathology. Osteoma, Osteoid / pathology
  • [MeSH-minor] Adolescent. Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Arthrography. Child. Diagnosis, Differential. Female. Femur Neck / diagnostic imaging. Femur Neck / pathology. Humans. Magnetic Resonance Imaging / methods. Male. Predictive Value of Tests. Sensitivity and Specificity. Synovial Membrane / diagnostic imaging. Synovial Membrane / pathology. Ultrasonography

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  • (PMID = 19444452.001).
  • [ISSN] 1437-160X
  • [Journal-full-title] Rheumatology international
  • [ISO-abbreviation] Rheumatol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal
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