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6. Dabholkar JP, Vora K, Vaidya A, Sharma A: Benign jaw tumors. Indian J Otolaryngol Head Neck Surg; 2009 Sep;61(3):240-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign jaw tumors.
  • They are usually benign in nature and can affect the functions of mastication, swallowing and cause facial deformity.
  • They make about 3% of all bone tumors with a tendency for a local recurrence if a wide excision is not contemplated at the first attempt.
  • Local destruction caused by the tumor can mimic a malignancy; however with imaging we can get a fair idea about the treatment planning.

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  • [Cites] Folia Med Cracov. 1998;39(1-2):35-141 [10481376.001]
  • [Cites] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Feb;99(2):191-5 [15660091.001]
  • [Cites] Br J Oral Maxillofac Surg. 2006 Oct;44(5):386-8 [16182417.001]
  • (PMID = 23120644.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3449977
  • [Keywords] NOTNLM ; Ameloblastoma / Dentigerous cyst / Jaw tumors / Odontomes / Osteoblastoma
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7. McLoughlin GS, Sciubba DM, Suk I, Witham T, Bydon A, Gokaslan ZL, Wolinsky JP: En bloc total sacrectomy performed in a single stage through a posterior approach. Neurosurgery; 2008 Jul;63(1 Suppl 1):ONS115-20; discussion ONS120
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  • OBJECTIVE: Total sacrectomies are performed for extensive en bloc tumor resections.
  • We present a case of a total en bloc sacrectomy performed entirely through the posterior approach, thereby avoiding the need for a laparotomy.
  • Results were consistent with an osteoblastoma, although osteosarcoma could not be excluded on pathological examination.
  • A combined transperineal approach completed the posterior dissection and the tumor was delivered en bloc.
  • CONCLUSION: With the use of interspace distraction and sacral elevation to facilitate vascular control, a total sacrectomy was performed without the need for the anterior exposure of a laparotomy.

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  • (PMID = 18728588.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Urbańczyk H, Miszczyk L: [Aggressive osteoblastoma of the larynx: case report]. Otolaryngol Pol; 2006;60(2):227-8
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  • [Title] [Aggressive osteoblastoma of the larynx: case report].
  • [Transliterated title] Guz krtani o utkaniu osteoblastoma agresiva: opis przypadku.
  • Osteoblastoma agressiva is not often bone tumor, only locally malignant.
  • Authors presented case of 45 year old patient, who was treated because of Aggressive Osteoblastoma localized in larynx.
  • The tumor localization and patients age--more than 35 year are unusual.
  • [MeSH-major] Laryngeal Neoplasms / pathology. Laryngeal Neoplasms / therapy. Osteoblastoma / pathology. Osteoblastoma / therapy

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  • (PMID = 16903343.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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9. Rawal YB, Angiero F, Allen CM, Kalmar JR, Sedghizadeh PP, Steinhilber AM: Gnathic osteoblastoma: clinicopathologic review of seven cases with long-term follow-up. Oral Oncol; 2006 Feb;42(2):123-30
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  • [Title] Gnathic osteoblastoma: clinicopathologic review of seven cases with long-term follow-up.
  • The clinical, radiographic and histopathologic features of seven cases of osteoblastoma of the jaw bones were analyzed.
  • The mandible was involved in six cases and a periosteal presentation of the tumor was noted in three cases.
  • A small periosteal tumor was undetectable radiographically.
  • Histopathologically, the tumors exhibited variation in woven bone formation, osteoblastic rimming, lesional maturation as well as interaction of the tumor with surrounding host tissue.
  • Intraosseous tumors were managed with aggressive surgical curettage and periosteal tumors were resected and the underlying bone was curetted down to normal host bone.
  • Gnathic osteoblastomas offer a unique diagnostic challenge as they resemble other tumors of the jaws including the cementoblastoma, cemento-ossifying fibroma, cemento-osseous dysplasia and most importantly the gnathic osteosarcoma.
  • [MeSH-major] Mandibular Neoplasms / pathology. Maxillary Neoplasms / pathology. Osteoblastoma / pathology

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  • (PMID = 16129654.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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10. Mortazavi SM, Wenger D, Asadollahi S, Shariat Torbaghan S, Unni KK, Saberi S: Periosteal osteoblastoma: report of a case with a rare histopathologic presentation and review of the literature. Skeletal Radiol; 2007 Mar;36(3):259-64
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  • [Title] Periosteal osteoblastoma: report of a case with a rare histopathologic presentation and review of the literature.
  • Osteoblastoma is an uncommon benign bone tumor most commonly located in the vertebral column or metaphysis of a long bone.
  • We report a periosteal-based osteoblastoma, arising from the proximal tibia, in a 20-year-old woman who presented with knee swelling and pain of 2-year duration.
  • Histopathologic evaluation disclosed immature bone and osteoid deposition in a vascularized stroma, associated with numerous osteoblasts and osteoclasts rimming the bony trabeculae.
  • Although extremely unusual, the presence of cartilage does not necessarily exclude the diagnosis of osteoblastoma.
  • [MeSH-major] Bone Neoplasms / diagnosis. Knee Joint / pathology. Osteoblastoma / diagnosis. Periosteum / pathology

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  • (PMID = 16868789.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 29
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11. Bruneau M, Polivka M, Cornelius JF, George B: Progression of an osteoid osteoma to an osteoblastoma. Case report. J Neurosurg Spine; 2005 Sep;3(3):238-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Progression of an osteoid osteoma to an osteoblastoma. Case report.
  • The authors report the unusual case of a 25-year-old man with occipitocervical pain related to a lesion of the C-1 lateral mass.
  • Initially this lesion measured 8 mm and exhibited radiological features of an osteoid osteoma.
  • Seven years later, as pain increased and became unresponsive to antiinflammatory drugs, computerized tomography scanning demonstrated progression to a 16-mm lesion, highly suspicious of an osteoblastoma.
  • Pathological examination of tissue samples confirmed the diagnosis of osteoblastoma.
  • Osteoid osteoma rarely evolves to osteoblastoma.
  • Deterioration of a patient's ability to control pain is a warning sign.
  • Insight into such cases underlines the importance of close long-term radiological follow-up examination in patients with conservatively treated osteoid osteomas.
  • [MeSH-major] Bone Neoplasms / pathology. Cell Transformation, Neoplastic. Osteoblastoma / pathology. Osteoma / pathology

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  • (PMID = 16235709.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents
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12. Todd AG, Gupta P: Unusual presentation of osteoblastoma in a patient with idiopathic scoliosis after posterior spinal fusion. Spine J; 2006 Nov-Dec;6(6):704-7
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  • [Title] Unusual presentation of osteoblastoma in a patient with idiopathic scoliosis after posterior spinal fusion.
  • BACKGROUND CONTEXT: Few studies have described the diagnosis of osteoblastoma of the spine as a cause of scoliosis.
  • These reports have described the tumor in conjunction with initial presentation of painful scoliosis.
  • This case report presents a case of osteoblastoma 9 years removed from diagnosis and fusion of idiopathic scoliosis in the thoracic spine.
  • PURPOSE: To report the late presentation of an osteoblastoma of the thoracic spine 9 years after posterior spinal fusion for scoliosis.
  • Magnetic resonance imaging of the thoracic spine indicated the presence of a mass in the spinal canal causing cord compression.
  • The patient underwent decompression with resection of the mass which was found to be an aggressive osteoblastoma.
  • CONCLUSIONS: We present osteoblastoma as a possible cause of low back pain and neurological deficit postfusion that should be considered in a differential diagnosis.
  • [MeSH-major] Bone Neoplasms / pathology. Osteoblastoma / pathology. Postoperative Complications. Scoliosis / surgery

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  • (PMID = 17088201.001).
  • [ISSN] 1529-9430
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Angiero F, Mellone P, Baldi A, Stefani M: Osteoblastoma of the jaw: report of two cases and review of the literature. In Vivo; 2006 Sep-Oct;20(5):665-70
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  • [Title] Osteoblastoma of the jaw: report of two cases and review of the literature.
  • Osteoblastoma is a benign bone tumor of osteoblastic origin.
  • Differential diagnosis and immunohistochemical features potentially useful for refining diagnosis of osteoblastoma are also discussed.
  • [MeSH-major] Biomarkers, Tumor / analysis. Jaw Neoplasms / pathology. Osteoblastoma / pathology

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  • (PMID = 17091775.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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4. Lian X, Zhao J, Hou T, Ma H, Chen Z: Benign intraspinal osteoblastoma stemming from C7 lamina in cervicothoracic junction: a case report. Spine (Phila Pa 1976); 2006 Nov 1;31(23):E895-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign intraspinal osteoblastoma stemming from C7 lamina in cervicothoracic junction: a case report.
  • STUDY DESIGN: A case report of a rare benign osteoblastoma successfully treated with total en bloc excision.
  • OBJECTIVES: To describe the clinical and radiographic features of an adolescent female patient with intraspinal osteoblastoma in cervicothoracic junction and the effect of surgical treatment.
  • SUMMARY OF BACKGROUND DATA: A rare case of massive benign osteoblastoma stemming from left side lamina of C7 and extension to spinal canal from C6 to T1 resulting in spinal cord compressed severely is reported.
  • RESULTS: The specimen of the removed mass was proven osteoblastoma pathologically.
  • Recurrence of the tumor was not seen at the final follow-up.
  • CONCLUSIONS: A case of massive intraspinal osteoblastoma stemming from C7 lamina was successfully treated by excised grossly with instrumentation for reconstruction of stability.
  • [MeSH-major] Cervical Vertebrae. Osteoblastoma / diagnosis. Osteoblastoma / surgery. Spinal Canal / surgery. Spinal Neoplasms / diagnosis. Spinal Neoplasms / surgery

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  • (PMID = 17077728.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Infante JR, Rayo JI, Serrano J, Domínguez ML, García L, Durán C: [Spinal osteoblastoma resection through radioguided surgery]. Rev Esp Med Nucl; 2010 Mar-Apr;29(2):78-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Spinal osteoblastoma resection through radioguided surgery].
  • [Transliterated title] Extirpación de un osteoblastoma vertebral mediante cirugía radiodirigida.
  • Osteoblastoma is an uncommon primary neoplasm of the bone, with histological manifestations similar to osteoid osteoma.
  • Bone scintigraphy demonstrates an increased radiotracer accumulation.
  • Nevertheless, localization of nidus may be difficult and bone resection may be limited due to the proximity of the neural structures.
  • We present the case of a patient with a spinal osteoblastoma in whom the use of radioguided surgery was performed through gamma probe and mini gamma camera.
  • This technique made it possible to accurately locate the tumor and perform an effective removal of the nidus.
  • [MeSH-major] Lumbar Vertebrae / surgery. Osteoblastoma / surgery. Radiology, Interventional. Spinal Neoplasms / surgery
  • [MeSH-minor] Diagnosis, Differential. Gamma Cameras. Humans. Male. Osteoma, Osteoid / diagnosis. Radiopharmaceuticals. Technetium Tc 99m Medronate / analogs & derivatives. Tomography, X-Ray Computed. Young Adult

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  • [Copyright] Copyright 2009 Elsevier España, S.L. y SEMNIM. All rights reserved.
  • (PMID = 19910079.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 72945-61-0 / technetium Tc 99m hydroxymethylene diphosphonate; X89XV46R07 / Technetium Tc 99m Medronate
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21. Shimizu N, Sakata K, Yamamoto I: Benign osteoblastoma of the temporal bone: Case report and review of the literature. Surg Neurol; 2006 Nov;66(5):534-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign osteoblastoma of the temporal bone: Case report and review of the literature.
  • BACKGROUND: Benign osteoblastoma arising from the temporal bone is extremely rare in elderly patients.
  • We reviewed the literature on benign osteoblastoma of the temporal bone and now propose a new classification of this pathologic entity based on its anatomical location in the temporal bone.
  • Preoperative computed tomography showed a bony destructive isodensity mass with calcified component involving the temporal bone.
  • After preoperative embolization on the day before surgery, the patient underwent tumor removal via a left infratemporal approach under neuronavigated guidance.
  • The pathologic examination revealed a benign osteoblastoma.
  • [MeSH-major] Bone Neoplasms / diagnosis. Osteoblastoma / diagnosis. Temporal Bone / pathology. Temporal Bone / radiography

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  • (PMID = 17084206.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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22. Harrop JS, Schmidt MH, Boriani S, Shaffrey CI: Aggressive "benign" primary spine neoplasms: osteoblastoma, aneurysmal bone cyst, and giant cell tumor. Spine (Phila Pa 1976); 2009 Oct 15;34(22 Suppl):S39-47
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aggressive "benign" primary spine neoplasms: osteoblastoma, aneurysmal bone cyst, and giant cell tumor.
  • OBJECTIVE: To define optimal clinical care for primary spinal aggressive "benign" osseous neoplasms using a systematic review with expert opinion.
  • METHODS: Predefined focused questions on treatment of osteoblastomas, aneurysmal bone cysts and giant cell tumors were refined by a panel of spine oncology surgeons, medical and radiation oncologist.
  • The osteoblastoma initial search identified 211 articles of which 17 were pertinent to the spinal questions.
  • The aneurysmal bone cysts initial search revealed 482 articles initially of which 6 were pertinent; and the search on giant cell tumors identified 178 articles of which only 8 were focused on the predefined treatment questions.
  • CONCLUSION: Spinal aggressive benign osseous neoplasms have varying histology.
  • Despite these differences surgical treatment should be directed at gross resection of the tumor, understanding that this may be limited by anatomic confines and the potential for morbidity.
  • [MeSH-major] Bone Cysts, Aneurysmal / therapy. Giant Cell Tumor of Bone / therapy. Osteoblastoma / therapy. Spinal Diseases / therapy. Spinal Neoplasms / therapy

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  • (PMID = 19829276.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 82
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23. Cai Y, Mohseny AB, Karperien M, Hogendoorn PC, Zhou G, Cleton-Jansen AM: Inactive Wnt/beta-catenin pathway in conventional high-grade osteosarcoma. J Pathol; 2010 Jan;220(1):24-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteosarcoma is the most common malignant bone tumour, with a peak incidence in children and young adolescents, suggesting a role of rapid bone growth in its pathogenesis.
  • Therefore, in this study, we examined nuclear beta-catenin expression in 52 human osteosarcoma biopsies, 15 osteoblastomas (benign bone tumours), and four human osteosarcoma cell lines by immunohistochemistry.
  • Furthermore, we modulated Wnt/beta-catenin pathway activity using a GIN (GSK3beta inhibitor) and evaluated its effect on cell growth and osteogenic differentiation.
  • Absence of nuclear beta-catenin staining was found in 90% of the biopsies and all osteosarcoma cell lines, whereas strong nuclear beta-catenin staining was observed in all osteoblastomas.
  • Wnt-luciferase activity was comparable to the negative control in all osteosarcoma cell lines.
  • Stimulation of the Wnt/beta-catenin pathway by GIN significantly reduced cell proliferation in the cell lines MG-63 and U-2-OS and enhanced differentiation in the cell lines HOS and SJSA-1, as shown by an increase in alkaline phosphatase (ALP) activity and mineralization.
  • Moreover, activation of the Wnt/beta-catenin pathway inhibits cell proliferation or promotes osteogenic differentiation in osteosarcoma cell lines.
  • [MeSH-major] Bone Neoplasms / physiopathology. Osteosarcoma / physiopathology. Wnt Proteins / physiology. beta Catenin / metabolism
  • [MeSH-minor] Animals. Cell Differentiation / physiology. Cell Proliferation. Glycogen Synthase Kinase 3 / antagonists & inhibitors. Glycogen Synthase Kinase 3 / physiology. Hedgehog Proteins / physiology. Humans. Intercellular Signaling Peptides and Proteins / metabolism. Mice. Neoplasm Proteins / metabolism. Neoplasm Proteins / physiology. Osteoblasts / pathology. Recombinant Proteins / pharmacology. Reverse Transcriptase Polymerase Chain Reaction / methods. Signal Transduction / drug effects. Signal Transduction / physiology. Tumor Cells, Cultured. Wnt3 Protein

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  • [CommentIn] J Pathol. 2010 Jan;220(1):1-4 [19890890.001]
  • (PMID = 19882675.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DKK1 protein, human; 0 / Hedgehog Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Neoplasm Proteins; 0 / Recombinant Proteins; 0 / Wnt Proteins; 0 / Wnt3 Protein; 0 / beta Catenin; EC 2.7.11.1 / glycogen synthase kinase 3 beta; EC 2.7.11.26 / Glycogen Synthase Kinase 3
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24. Avadhanam PK, Vuyyur S, Panigrahi MK: A rare occurrence of osteoblastoma in a child. J Pediatr Neurosci; 2010 Jul;5(2):153-6
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  • [Title] A rare occurrence of osteoblastoma in a child.
  • To report a rare occurrence of osteoblastoma involving the L4 vertebra in an 8-year-old female child with histological features suggestive of osteoblastoma with secondary aneurysmal changes.
  • The mean age incidence of osteoblastoma is 20.4 years.
  • In our case, a rare presentation of osteoblastoma was seen in the first decade.
  • Decompression of the L5 nerve and resection of the tumor was performed.
  • Osteoblastoma is a rare tumor with an incidence of 1% of all tumors and 30-40% of cases involving the spine.
  • Osteoblastoma occurs most commonly in males (M:F, 2.5:1).

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  • [Cites] Neurol India. 1999 Dec;47(4):330-1 [10625912.001]
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  • (PMID = 21559167.001).
  • [ISSN] 1998-3948
  • [Journal-full-title] Journal of pediatric neurosciences
  • [ISO-abbreviation] J Pediatr Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3087998
  • [Keywords] NOTNLM ; Benign tumors of spine / osteoblastoma / osteoblastoma in childhood
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25. Gibson SE, Prayson RA: Primary skull lesions in the pediatric population: a 25-year experience. Arch Pathol Lab Med; 2007 May;131(5):761-6
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  • These lesions were usually benign and most commonly presented as a painless mass (n = 8).
  • The lesions were located in the occipital bone (n = 7), frontal bone (n = 5), parietal bone (n = 2), and temporal bone (n = 1).
  • Diagnoses included epidermoid/dermoid cyst (n = 8), Langerhans cell histiocytosis (n = 6), intraosseous hemangioma (n = 2), osteoblastoma (n = 1), infantile myofibroma (n = 1), and fibroma (n = 1).
  • CONCLUSIONS: Epidermoid/dermoid cysts and Langerhans cell histiocytosis are the most commonly encountered skull lesions in the pediatric population at our institution.

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  • (PMID = 17488162.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Chai JW, Hong SH, Choi JY, Koh YH, Lee JW, Choi JA, Kang HS: Radiologic diagnosis of osteoid osteoma: from simple to challenging findings. Radiographics; 2010 May;30(3):737-49
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  • [Title] Radiologic diagnosis of osteoid osteoma: from simple to challenging findings.
  • Osteoid osteoma is characterized by an intracortical nidus with a variable amount of calcification, as well as cortical thickening, sclerosis, and bone marrow edema.
  • When these findings are present, a diagnosis of osteoid osteoma is easily made.
  • However, osteoid osteoma may display imaging findings that can be misleading, and it can be difficult to differentiate osteoid osteoma from other conditions such as infection, inflammatory and noninflammatory arthritis, and other tumors.
  • In addition, stress fracture, intracortical abscess, intracortical hemangioma, chondroblastoma, osteoblastoma, and compensatory hypertrophy of the pedicle may mimic osteoid osteoma.
  • To make the correct diagnosis, it is necessary to identify the nidus, and it is important to be familiar with the radiologic findings of osteoid osteoma and its mimics.
  • [MeSH-major] Bone Neoplasms / diagnosis. Osteoma, Osteoid / diagnosis. Osteosarcoma / diagnosis. Tomography, X-Ray Computed / methods

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  • [ErratumIn] Radiographics. 2010 Jul-Aug;30(4):1156
  • (PMID = 20462991.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Shears E, Dehne K, Murata H, Abudu A, Grimer RJ, Tillman RM, Carter SR: Healing of ungrafted bone defects of the talus after benign tumour removal. Foot Ankle Surg; 2008;14(3):161-5
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  • [Title] Healing of ungrafted bone defects of the talus after benign tumour removal.
  • BACKGROUND: Curettage of benign tumours commonly results in significant bone defects that are reconstructed with autologous grafts, allografts, bone cement or bone substitute.
  • We have treated such defects in the talus without reconstruction with bone or any other material.
  • We now report the healing of these ungrafted defects in eight patients treated with curettage for benign talar tumours.
  • CONCLUSIONS: We conclude that bone grafting is not a necessary adjunct to the curettage of talar lesions.
  • [MeSH-major] Bone Neoplasms / surgery. Talus / surgery. Wound Healing
  • [MeSH-minor] Adolescent. Adult. Child. Chondroblastoma / surgery. Curettage. Female. Follow-Up Studies. Ganglion Cysts / surgery. Humans. Male. Osteoarthritis / etiology. Osteoblastoma / surgery. Postoperative Complications. Retrospective Studies. Young Adult

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  • (PMID = 19083636.001).
  • [ISSN] 1460-9584
  • [Journal-full-title] Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons
  • [ISO-abbreviation] Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
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28. Arpino L, Gragnaniello C, Nina P, Franco A: Limited approach to a thoracic spine osteoblastoma. J Neurosurg Sci; 2008 Dec;52(4):123-5; discussion 125
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  • [Title] Limited approach to a thoracic spine osteoblastoma.
  • Osteoblastoma (OB) is a rare primary benign bone tumor.
  • It is important to differentiate OB from osteoid osteoma, a very similar bone tumor.
  • This article describes a 18-year-old female affected from a thoracic osteoblastoma stemming from T9 lamina and extending to T11, with a diameter of about 2.5 cm.
  • OB is rare benign bone neoplasm that generally affect the posterior elements of the spine.
  • [MeSH-major] Neurosurgical Procedures / methods. Osteoblastoma / surgery. Spinal Neoplasms / surgery. Thoracic Vertebrae / surgery

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  • (PMID = 18981987.001).
  • [ISSN] 0390-5616
  • [Journal-full-title] Journal of neurosurgical sciences
  • [ISO-abbreviation] J Neurosurg Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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29. Tamiolakis D, Thomaidis V, Tsamis I, Alexiadis G, Seretis K: Clinical, radiological and histological correlation in the diagnostic work-up of cemento-ossifying fibroma of the maxilla: case report. Chirurgia (Bucur); 2007 May-Jun;102(3):359-62
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  • [Title] Clinical, radiological and histological correlation in the diagnostic work-up of cemento-ossifying fibroma of the maxilla: case report.
  • Cemento-ossifying fibroma is a relatively rare tumor classified between fibro-osseous lesions.
  • This lesion appears within the bone although in some occasions it involves the gingivae soft tissues.
  • It is a slow growing and well-defined tumorous lesion, because of this, it is considered as a benign lesion.
  • We report a case of a young female presenting a mass in the right cheek.
  • The histology was that of a benign fibro-osseous proliferation composed of bony spicules and spherules admixed with a fibrous stroma.
  • The histologic findings alone may be similar to other pathologies such as osteoblastoma, low-grade osteosarcoma and particularly to fibrous dysplasia.
  • [MeSH-major] Fibroma, Ossifying / diagnosis. Maxillary Neoplasms / diagnosis

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  • (PMID = 17687869.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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30. El-Gammal TA, El-Sayed A, Kotb MM, Saleh WR, Ragheb YF: Knee joint reconstruction after hemiarticular resection using pedicled patella and vascularized fibular graft. Microsurgery; 2010 Nov;30(8):603-7
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  • Tumor pathology was giant cell tumor in four patients, osteoblastoma in two, and benign fibrous histocytoma in one patient.
  • The tumor was located in the distal femur in five patients and in the proximal tibia in the remaining two.
  • Average time to bone union was 3.5 months (range, 3-4 months), and average time to full weight-bearing was 5 months (range, 4-6 months).
  • [MeSH-major] Bone Neoplasms / surgery. Giant Cell Tumor of Bone / surgery. Knee Joint / surgery. Surgical Flaps
  • [MeSH-minor] Adolescent. Adult. Female. Histiocytoma, Benign Fibrous / surgery. Humans. Male. Osteoblastoma / surgery. Range of Motion, Articular. Young Adult

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  • [Copyright] Copyright © 2010 Wiley-Liss, Inc.
  • (PMID = 20853338.001).
  • [ISSN] 1098-2752
  • [Journal-full-title] Microsurgery
  • [ISO-abbreviation] Microsurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Varshney MK, Trikha V, Rastogi S: Aggressive osteoblastoma of clavicle a rare tumor at previously undescribed site. Acta Oncol; 2007;46(2):259-61
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  • [Title] Aggressive osteoblastoma of clavicle a rare tumor at previously undescribed site.
  • [MeSH-major] Bone Neoplasms / radiography. Clavicle / radiography. Osteoblastoma / radiography

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  • (PMID = 17453380.001).
  • [ISSN] 0284-186X
  • [Journal-full-title] Acta oncologica (Stockholm, Sweden)
  • [ISO-abbreviation] Acta Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Norway
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32. Ntagiopoulos PG, Anastopoulos G, Zacharakis N, Asimakopoulos A: Re: metacarpal osteoblastoma treated with non-vascularized fibular graft: 8 years follow-up. J Hand Surg Eur Vol; 2008 Oct;33(5):679-81
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  • [Title] Re: metacarpal osteoblastoma treated with non-vascularized fibular graft: 8 years follow-up.
  • [MeSH-major] Bone Neoplasms / surgery. Fibula / transplantation. Metacarpal Bones. Osteoblastoma / surgery
  • [MeSH-minor] Adult. Disease-Free Survival. Female. Follow-Up Studies. Humans. Time Factors

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  • (PMID = 18977842.001).
  • [ISSN] 1753-1934
  • [Journal-full-title] The Journal of hand surgery, European volume
  • [ISO-abbreviation] J Hand Surg Eur Vol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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33. Lin YC, Commins DL, Fedenko AN, Pinsky GS: A rare case of periosteal osteoblastoma located in the frontal cranial bone. Arch Pathol Lab Med; 2005 Jun;129(6):787-9
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  • [Title] A rare case of periosteal osteoblastoma located in the frontal cranial bone.
  • Periosteal osteoblastoma is an extremely rare bone-forming neoplasm located on the surface of cortical bone.
  • Of the fewer than 30 cases of periosteal osteoblastomas found in the literature, 2 have been reported to be located in cranial bone, and these have not been documented in detail with clinical history, radiographic findings, macroscopic features, and microscopic findings.
  • Although the differential diagnoses of periosteal lesions include parosteal and periosteal osteosarcoma, periosteal chondroma and chondrosarcoma, osteochondroma, osteoid osteoma, periostitis ossificans, and myositis ossificans, an important differential diagnosis both radiologically and pathologically of such a lesion in the cranium is meningioma.
  • We report an unusual case of periosteal osteoblastoma located in the frontal cranial bone that was radiologically consistent with a meningioma.
  • The differential diagnosis of metaplastic meningioma with differentiation toward bone is discussed.
  • [MeSH-major] Frontal Bone / pathology. Osteoblastoma / pathology. Periosteum / pathology. Skull Neoplasms / pathology

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  • (PMID = 15913430.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Woźniak AW, Nowaczyk MT, Osmola K, Golusinski W: Malignant transformation of an osteoblastoma of the mandible: case report and review of the literature. Eur Arch Otorhinolaryngol; 2010 Jun;267(6):845-9
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  • [Title] Malignant transformation of an osteoblastoma of the mandible: case report and review of the literature.
  • Benign osteoblastoma is a rarely seen tumor of the facial bones.
  • The authors present a case of a 30-year-old man with a tumor of the mandibular body and ramus.
  • The histopathological diagnosis was one of osteoblastoma.
  • Postoperative recurrence with soft tissue infiltration suggested an osteosarcoma radiologically, but the histological examination again revealed the presence of an osteoblastoma.
  • A second recurrence occured in the pharyngo-glossal region and this time the tumor was histologically diagnosed as an osteoblastoma, but with foci of well-differentiated osteosarcoma.
  • While osteoblastomas are rare, and their sarcomatous change even rarer, our experience with this case lead us to suggest that a therapeutic preventative approach, involving both chemotherapy and total excision of the tumor, is the regime to adopt with osteoblastomas which involve soft tissues and have radiological features suggesting malignancy.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Mandibular Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Osteoblastoma / pathology. Osteosarcoma / pathology

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  • (PMID = 20012077.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 20
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35. Qian BP, Qiu Y, Zhu Z, Chen H: Spinal osteoblastoma complicated with epidural hematoma: two case reports. Spine (Phila Pa 1976); 2009 May 20;34(12):E447-51
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  • [Title] Spinal osteoblastoma complicated with epidural hematoma: two case reports.
  • OBJECTIVE: To describe 2 patients of spinal osteoblastoma in upper thoracic lamina, complicated with epidural hematoma and symptoms of cord compression.
  • RESULTS: Histologic diagnosis indicated destructive osteoblastomas with hemorrhage.
  • Both patients had no evidence of tumor recurrence at an average follow-up of 37 months.
  • CONCLUSION: By using surgical resection and hematoma evacuation, good outcome could be achieved for spinal osteoblastoma complicated with epidural hematoma.
  • [MeSH-major] Hematoma, Epidural, Spinal / pathology. Osteoblastoma / pathology. Spinal Cord Compression / pathology. Spinal Neoplasms / pathology. Thoracic Vertebrae / pathology

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  • (PMID = 19454998.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. Jerome T, Sankaran B, Varghese M: Rare combination of cervical spine tumours. BMJ Case Rep; 2009;2009
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  • Osteoid osteoma, osteoblastoma, and haemangioma should be included in the differential diagnosis of any young patient with pain in the back or the neck, painful scoliosis, or radicular or referred-type pain into the lower limb or the shoulder.
  • Osteoid osteoma and haemangioma may occur in the same cervical spine and both have a significant importance in the prognosis, management and possible complications.
  • Early diagnosis with a bone scan and computed tomography scan, leading to prompt treatment, decreases the average duration of symptoms by two thirds.

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  • (PMID = 21686942.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3028045
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37. Gomez-Brouchet A, Mourcin F, Gourraud PA, Bouvier C, De Pinieux G, Le Guelec S, Brousset P, Delisle MB, Schiff C: Galectin-1 is a powerful marker to distinguish chondroblastic osteosarcoma and conventional chondrosarcoma. Hum Pathol; 2010 Sep;41(9):1220-30
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  • The clinical management of osteosarcoma differs significantly from that of chondrosarcoma; therefore, it is extremely important to diagnose these 2 types of bone tumor accurately.
  • In the absence of a specific marker, differential diagnosis by histochemistry is sometimes impossible, especially between chondroblastic osteosarcoma and conventional chondrosarcoma.
  • We analyzed 165 bone sarcomas by immunohistochemical staining of tissue microarrays for expression of the galectin-1 (GAL1) lectin and by Western blot experiments.
  • We found that GAL1 was abundant in normal human osteoblasts from benign proliferations and in osteosarcomas, including chondroblastic osteosarcomas, but not in chondrosarcomas.
  • We propose a diagnostic test for bone tumors that takes into account the optimal discriminative values for the percentage of cells stained and the intensity of staining.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Bone Neoplasms / diagnosis. Chondrosarcoma / diagnosis. Galectin 1 / metabolism. Osteosarcoma / diagnosis
  • [MeSH-minor] Adolescent. Blotting, Western. Cell Count. Chondrocytes / metabolism. Chondrocytes / pathology. Diagnosis, Differential. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Osteoblastoma / metabolism. Osteoblastoma / pathology. Periostitis / metabolism. Periostitis / pathology. Tissue Array Analysis


38. Kyriakos M, El-Khoury GY, McDonald DJ, Buckwalter JA, Sundaram M, DeYoung B, O'Brien MP: Osteoblastomatosis of bone. A benign, multifocal osteoblastic lesion, distinct from osteoid osteoma and osteoblastoma, radiologically simulating a vascular tumor. Skeletal Radiol; 2007 Mar;36(3):237-47
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  • [Title] Osteoblastomatosis of bone. A benign, multifocal osteoblastic lesion, distinct from osteoid osteoma and osteoblastoma, radiologically simulating a vascular tumor.
  • Two adult patients are described with multifocal osteolytic lesions radiologically simulating a vascular tumor.
  • Histologically, the individual lesions had the features of the nidus of osteoid osteoma/osteoblastoma.
  • The process is designated as osteoblastomatosis to indicate its bone-forming character, prominent osteoblast proliferation, and multiplicity.
  • The cases are distinguished from multifocal/multicentric osteoid osteoma and osteoblastoma, and from benign and malignant vascular tumors.
  • [MeSH-major] Bone Neoplasms / diagnosis. Leg Bones / pathology. Osteoblastoma / diagnosis
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Osteoma, Osteoid / diagnosis. Vascular Neoplasms / diagnosis

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  • (PMID = 16639626.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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39. Tawil A, Comair Y, Nasser H, Hourani R, Rebeiz J, Chamoun R: Periosteal osteoblastoma of the calvaria mimicking a meningioma. Pathol Res Pract; 2008;204(6):413-22
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  • [Title] Periosteal osteoblastoma of the calvaria mimicking a meningioma.
  • While osteoblastoma of the cranial vault is rare, the periosteal form of the tumor is highly unusual, with only one case reported in the English literature.
  • Magnetic resonance imaging of the brain showed an extra-axial temporal mass with findings that were suggestive of a meningioma.
  • The mass was excised completely, and histological examination revealed a periosteal osteoblastoma arising from the inner surface of the temporal bone and adhering to the dura.
  • The tumor was strongly positive for epithelial membrane antigen, a feature not previously described in osteoblastoma, and one that could lead to a mistaken diagnosis of metaplastic meningioma in a limited sample.
  • A detailed literature review of 40 other reported cases of calvarial osteoblastoma is presented.
  • Apart from being slightly more common in females, calvarial osteoblastoma is similar in all other respects to that arising at conventional skeletal sites.
  • Accurate histological diagnosis of a calvarial osteoblastoma requires adequate sampling of the tumor, including its interface with adjacent structures.
  • [MeSH-major] Bone Neoplasms / diagnosis. Meningioma / diagnosis. Osteoblastoma / diagnosis. Skull / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Mucin-1 / analysis. Treatment Outcome

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  • (PMID = 18359169.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucin-1
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40. Arantes M, Resende M, Honavar M, Pires MM, Pereira JR, Vaz AR: Benign osteoblastoma of the sphenoid bone. Skull Base; 2009 Nov;19(6):437-41
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  • [Title] Benign osteoblastoma of the sphenoid bone.
  • Osteoblastoma is an uncommon benign bone tumor that accounts for 1% of all primary bone tumors.
  • Well documented in the spine and long bones, it is rarely found in the skull, namely in the sphenoid bone, with only five cases reported in the literature.
  • We report a case of an 11-year-old girl with a histologically confirmed benign osteoblastoma in an unusual location and an atypical aspect on the imaging studies.

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  • [Cites] Cancer. 1956 Sep-Oct;9(5):1044-52 [13364889.001]
  • (PMID = 20436846.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2793891
  • [Keywords] NOTNLM ; Benign osteoblastoma / child / radical resection / sphenoid bone
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41. Charfi S, Khabir A, Ayadi L, Makni S, Toumi N, Frikha M, boudawara T: [Primary osteoblastoma-like osteosarcoma of the sternum: a case report]. Presse Med; 2007 Feb;36(2 Pt 1):253-4
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  • [Title] [Primary osteoblastoma-like osteosarcoma of the sternum: a case report].
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Neoplasms / pathology. Osteoblastoma / pathology. Osteosarcoma / pathology

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  • (PMID = 17357233.001).
  • [ISSN] 0755-4982
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
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42. Sang H, Wang Z, Guo Z, Wang L, Li J, Meng G, Li X, Lu J: [Clinical results and the mechanism of bone healing for the repair of bone defects due to tumor resection with novel interporous TCP]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2008 Apr;22(4):463-7
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  • [Title] [Clinical results and the mechanism of bone healing for the repair of bone defects due to tumor resection with novel interporous TCP].
  • OBJECTIVE: To investigate the clinical results and the mechanism of bone healing for the repair of bone defects following tumor resection with novel interporous TCP bone graft, and to test the hypothesis of "structural transplantation".
  • METHODS: From January 2003 to December 2005, 61 cases of various bone defects following the curettage of the benign bone tumors were treated with interporous TCP, with 33 males and 28 females, including bone fibrous dysplasia in 8 cases, bone cyst in 23 cases, eosinophilic granuloma in 12 cases, enchondroma in 13 cases, non-ossifying fibroma in 2 cases, and osteoblastoma in 3 cases.
  • Tumor sizes varied from 1.5 cm x 1.0 cm to 7.0 cm x 5.0 cm.
  • They all had good wound healing and bone regeneration.
  • The bone defects were repaired gradually from 1 to 6 months after operation (bone healing at average 2.6 months after surgery) with a bone healing rate up to 96.7%.
  • Given revision operation, this case gained bone healing.
  • Radiographically, the interface between the implanted bone and host bone became fuzzy 1 month after implantation, indicating the beginning of new bone formation.
  • Three months later, the absorption of the interporous TCP was noticed from peripheral to the center of the implanted bone evidenced by the vague or fuzzy realm.
  • New bone formation could be seen both in peripheral and central areas.
  • Six months later, implanted bone and host bone merged together and the bone defect was totally repaired, with 78.9% degradation rate of the implanted TCP.
  • Twelve months later, the majority of the implanted bone was absorbed and bone remodeling was established.
  • In the cases that were followed up for 24 months, the function of affected extremity was excellent with good bone remodeling without recurrence.
  • Pathologically, the interporous TCP closely contacted the host bone inside the humerus 1 month after grafting.
  • The interface between the implanted bone and host bone became fuzzy, and vascularized tissue began growing inside the implanted graft as a "lining" structure.
  • CONCLUSION: The interporous TCP proves to be effective for clinical reparation of bone defects following tumor resection.
  • The inside three-dimensional porous structure simulates the natural bionic bone structure which is suitable for recruitment related cells in-growth into the scaffold, colonizing and proliferation companied with the process of vascularize, finally with the new bone formation.
  • The novel interporous TCP may boast both bone conductive and bone inductive activities, as an appealing "structural transplantation" bone graft.
  • [MeSH-major] Bone Diseases / surgery. Bone Neoplasms / surgery. Bone Substitutes. Calcium Phosphates. Prostheses and Implants. Wound Healing
  • [MeSH-minor] Adolescent. Adult. Biocompatible Materials. Bone Regeneration / physiology. Bone Transplantation. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Male. Middle Aged. Reconstructive Surgical Procedures. Treatment Outcome

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  • (PMID = 18575450.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Bone Substitutes; 0 / Calcium Phosphates
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43. Saglik Y, Atalar H, Yildiz Y, Basarir K, Gunay C: Surgical treatment of osteoblastoma : a report of 20 cases. Acta Orthop Belg; 2007 Dec;73(6):747-53
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  • [Title] Surgical treatment of osteoblastoma : a report of 20 cases.
  • Osteoblastoma is a locally aggressive osteoblastic lesion of bone with rare malignant transformation.
  • We retrospectively evaluated 20 patients who were diagnosed and surgically treated for osteoblastoma in our institution.
  • This series demonstrates that osteoblastoma may be locally aggressive and may recur after removal.
  • [MeSH-major] Bone Neoplasms / surgery. Osteoblastoma / surgery

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  • (PMID = 18260488.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
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44. Deyrup AT, Montag AG: Epithelioid and epithelial neoplasms of bone. Arch Pathol Lab Med; 2007 Feb;131(2):205-16
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  • [Title] Epithelioid and epithelial neoplasms of bone.
  • CONTEXT: Epithelioid and epithelial neoplasms seen in bone are rare and include epithelioid variants of vascular lesions, osteoblastoma, osteosarcoma, chordoma, and chondroblastoma as well as adamantinoma and metastatic carcinoma.
  • CONCLUSIONS: The differential diagnosis in epithelioid/epithelial lesions of bone is limited.
  • [MeSH-major] Bone Neoplasms / pathology. Neoplasms, Glandular and Epithelial / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Neoplasm Metastasis / pathology

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  • (PMID = 17284104.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 86
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45. Lee YG, Cho CW: Benign osteoblastoma located in the parietal bone. J Korean Neurosurg Soc; 2010 Aug;48(2):170-2
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  • [Title] Benign osteoblastoma located in the parietal bone.
  • Benign osteoblastoma is an uncommon primary bone tumor, extremely rare in calvarium.
  • We present a case of a 25-year-old female with an osteoblastoma of parietal bone which was totally resected.
  • The authors discussed the clinical presentation, radiographic finding, differential diagnosis and management of the benign calvarial osteoblastoma with a review of the literature.

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  • (PMID = 20856669.001).
  • [ISSN] 1598-7876
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2941863
  • [Keywords] NOTNLM ; Osteoblastoma / Parietal bone
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46. Shintaku WH, Venturin JS, Langlais RP, Clark GT: Imaging modalities to access bony tumors and hyperplasic reactions of the temporomandibular joint. J Oral Maxillofac Surg; 2010 Aug;68(8):1911-21
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  • Benign and malignant tumors in the temporomandibular joint (TMJ) are rare.
  • However, when a patient presents with clinical findings such as altered occlusion or facial asymmetry, a morphologic alteration in the condyle should be ruled out.
  • The differential diagnosis for benign hyperplastic bony lesions in the TMJ should include condylar hyperplasia, osteochondroma, osteoma, chondroma, and osteoblastoma.
  • Imaging can be classified as morphologic or functional according to the information provided.
  • To differentiate benign and malignant bony tumors, magnetic resonance imaging has a sensitivity and specificity of 44% and 95%, respectively.
  • The combination of morphologic and functional (single positron emission CT and positron emission tomography) modalities appears to improve the sensitivity and specificity to assess a hyperplastic condyle, facilitating treatment planning and providing a better prognosis for the patient.
  • [MeSH-major] Bone Neoplasms / diagnosis. Diagnostic Imaging / methods. Head and Neck Neoplasms / diagnosis. Temporomandibular Joint Disorders / diagnosis


47. Villalobos CE, Rybak LD, Steiner GC, Wittig JC: Osteoblastoma of the sternum--case report and review of the literature. Bull NYU Hosp Jt Dis; 2010;68(1):55-9
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  • [Title] Osteoblastoma of the sternum--case report and review of the literature.
  • Osteoblastoma is an extremely rare entity that represents less than 1% of all bone tumors, and affects twice as many males as females with peak incidence between 15 and 20 years.
  • Osteoblastomas commonly affect axial bones, long bones, bones of the foot and hand, and less commonly the pelvis, scapula, ribs, and clavicle.
  • Osteoblastoma does not have a classic presentation, but can vary with the location and size of the tumor.
  • The main complaint is often progressive pain localized at the tumor site.
  • Osteoblastoma is a benign tumor with an aggressive behavior.
  • The treatment is wide surgical resection, otherwise it continues to enlarge and destroy the bone and surrounding structures.
  • We report a 32-year-old male with an osteoblastoma of this sternum who was treated with an en-bloc resection and reconstruction with Marlex((R)) and a methylmethacrylate plate.
  • [MeSH-major] Bone Neoplasms / surgery. Orthopedic Procedures. Osteoblastoma / surgery. Sternum / surgery
  • [MeSH-minor] Adult. Biopsy. Bone Plates. Humans. Magnetic Resonance Imaging. Male. Methylmethacrylate. Polypropylenes. Prosthesis Design. Surgical Mesh. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20345366.001).
  • [ISSN] 1936-9727
  • [Journal-full-title] Bulletin of the NYU hospital for joint diseases
  • [ISO-abbreviation] Bull NYU Hosp Jt Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Polypropylenes; 196OC77688 / Methylmethacrylate
  • [Number-of-references] 22
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48. James SL, Panicek DM, Davies AM: Bone marrow oedema associated with benign and malignant bone tumours. Eur J Radiol; 2008 Jul;67(1):11-21
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  • [Title] Bone marrow oedema associated with benign and malignant bone tumours.
  • Bone marrow oedema is associated with a wide variety of pathological processes including both benign and malignant bone tumours.
  • This imaging finding in relation to intraosseous tumours can aid in providing a more focused differential diagnosis.
  • In this review, we will discuss the MR imaging of bone marrow oedema surrounding intraosseous neoplasms.
  • Benign lesions commonly associated with bone marrow oedema include osteoid osteoma, osteoblastoma, chondroblastoma and Langerhan's cell histiocytosis.
  • Metastases and malignant primary bone tumours such as osteosarcoma, Ewing's sarcoma and chondrosarcoma may also be surrounded by bone marrow oedema.
  • Finally, the importance of bone marrow oedema in assessment of post chemotherapeutic response is addressed.
  • [MeSH-major] Bone Marrow Diseases / complications. Bone Marrow Diseases / diagnosis. Bone Neoplasms / complications. Bone Neoplasms / diagnosis. Diagnostic Imaging / methods. Edema / complications. Edema / diagnosis


49. Gazzeri R, Tamorri M, Bernardi C, Alfieri A, Gazzeri G: Lumbar spinal osteoblastoma mimicking a dumbbell radicular schwannoma. Zentralbl Neurochir; 2008 Nov;69(4):191-3
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  • [Title] Lumbar spinal osteoblastoma mimicking a dumbbell radicular schwannoma.
  • We report a case of a 20-year-old man who presented with back pain radiating to his left lower limb mostly when in a supine position.
  • Although MR imaging studies were strongly suggestive of a dumbbell radicular schwannoma, the histological diagnosis was an osteoblastoma of the lumbar spine originating from the left L5 pedicle with intracanalicular, intraforaminal and extracanalicular extension.
  • [MeSH-major] Neurilemmoma / pathology. Osteoblastoma / pathology. Spinal Neoplasms / pathology

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  • (PMID = 18666061.001).
  • [ISSN] 0044-4251
  • [Journal-full-title] Zentralblatt für Neurochirurgie
  • [ISO-abbreviation] Zentralbl. Neurochir.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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50. Giannico G, Holt GE, Homlar KC, Johnson J, Pinnt J, Bridge JA: Osteoblastoma characterized by a three-way translocation: report of a case and review of the literature. Cancer Genet Cytogenet; 2009 Dec;195(2):168-71
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  • [Title] Osteoblastoma characterized by a three-way translocation: report of a case and review of the literature.
  • Osteoblastoma, an uncommon primary bone tumor, produces both osteoid and primitive woven bone in a background of fibrovascular connective tissue.
  • Although most osteoblastomas are considered benign, a controversial aggressive variant has been described, which may cause diagnostic confusion with malignant tumors such as osteosarcoma.
  • To date, no specific diagnostic cytogenetic or molecular marker has been identified for osteoblastoma to aid in its distinction.
  • Conventional cytogenetic analysis of an osteoblastoma arising in the femur of a 23-year-old woman revealed a novel three-way translocation involving chromosomes 1, 2 and 14 [t(1;2;14) (q42;q13;q24)].
  • [MeSH-major] Bone Neoplasms / genetics. Osteoblastoma / genetics. Translocation, Genetic

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  • (PMID = 19963118.001).
  • [ISSN] 1873-4456
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 20
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51. Muzumdar D, Balasubramaniam S, Jhawar S, Goel A: Massive benign osteoblastoma of the suboccipital bone and foramen magnum region. Pediatr Neurosurg; 2010;46(3):232-7
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  • [Title] Massive benign osteoblastoma of the suboccipital bone and foramen magnum region.
  • Benign osteoblastoma is an uncommon primary bone tumor frequently found in the vertebral column and long tubular bones, and rarely occurring in the calvarium.
  • A case of a massive benign osteoblastoma of the suboccipital bone and foramen magnum region in a 9-year-old boy is reported.
  • The atlas was uninvolved by the tumor.
  • The tumor was completely resected with wide margins via a suboccipital route.
  • The occurrence of benign osteoblastoma in the suboccipital bone and foramen magnum region has not been reported earlier in the pediatric population.
  • [MeSH-major] Foramen Magnum / surgery. Occipital Bone / surgery. Osteoblastoma / surgery. Skull Neoplasms / surgery

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  • [Copyright] Copyright © 2010 S. Karger AG, Basel.
  • (PMID = 21051923.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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52. Hosono A, Yamaguchi U, Makimoto A, Endo M, Watanabe A, Shimoda T, Kaya M, Matsumura T, Sonobe H, Kusumi T, Yamaguchi T, Hasegawa T: Utility of immunohistochemical analysis for cyclo-oxygenase 2 in the differential diagnosis of osteoblastoma and osteosarcoma. J Clin Pathol; 2007 Apr;60(4):410-4
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  • [Title] Utility of immunohistochemical analysis for cyclo-oxygenase 2 in the differential diagnosis of osteoblastoma and osteosarcoma.
  • AIMS: To study the immunoexpression of cyclo-oxygenase (COX) 2 in osteoblastomas (OBs) and osteosarcomas (OSs), and to assess the utility of immunohistochemical analysis for COX 2 in the differential diagnosis of the two tumour forms.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Bone Neoplasms / diagnosis. Clinical Enzyme Tests / methods. Cyclooxygenase 2 / metabolism. Osteoblastoma / diagnosis. Osteosarcoma / diagnosis

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  • (PMID = 16822878.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 1.14.99.1 / Cyclooxygenase 2
  • [Other-IDs] NLM/ PMC2001122
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53. Deyrup AT, Monson DK, Dorfman HD: Aggressive (epithelioid) osteoblastoma arising in soft tissue. Int J Surg Pathol; 2008 Jul;16(3):308-10
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  • [Title] Aggressive (epithelioid) osteoblastoma arising in soft tissue.
  • Aggressive (epithelioid) osteoblastoma arising in soft tissue has never been described.
  • It is important to differentiate this benign osteoblastoma, a potentially locally aggressive tumor, from extraskeletal osteosarcoma.
  • This report describes an aggressive (epithelioid) osteoblastoma arising in a focus of heterotopic ossification in the axilla of a 21-year-old man.
  • [MeSH-major] Bone Neoplasms / diagnosis. Epithelioid Cells / pathology. Ossification, Heterotopic / pathology. Osteoblastoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Axilla. Disease-Free Survival. Humans. Immunohistochemistry. Male. Shoulder / radiography

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  • (PMID = 18573786.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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54. Vetrilé ST, Shkarubo AN, Morozov AK, Kuleshov AA, Kolbovskiĭ DA: [Tactics of surgical treatment for an inflammatory process of C0-C(I)-C(II) segments in the craniovertebral joint instability]. Zh Vopr Neirokhir Im N N Burdenko; 2006 Oct-Dec;(4):20-4; discussion 24
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  • On removal of a sizable pathological focus, there may be instability of the craniovertebral segment, secondary displacement, and spinal compression syndrome.
  • A differential diagnosis was made between chordoma, osteoblastoma, and an inflammatory focus at the above site.
  • The following tactics was undertaken: the first stage was occipitospondylosynthesis with "Vertex" system with osteoplasty under Halo-traction; the second stage included transoral removal of a pathological removal of the dens and body of the C(II) vertebra, left lateral mass of the CI vertebra, and lower clivus.
  • After removal of the pathological focus, there were portions of the abnormally changed bone with rarefaction without tumor tissue.
  • Histologic studies revealed the signs of a chronic inflammatory process.
  • Thus, there is evidence for the tactics of successive operations (a stabilizing operation--posterior occipitospondylosynthesis (desirably under Halo-traction), followed by removal of a pathological focus via transoral access) in pathological processes of the craniovertebral C0-C(I)-C(II) in cases of initial craniovertebral junction instability.

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  • (PMID = 17195373.001).
  • [ISSN] 0042-8817
  • [Journal-full-title] Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko
  • [ISO-abbreviation] Zh Vopr Neirokhir Im N N Burdenko
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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55. Owen RJ: Embolization of musculoskeletal bone tumors. Semin Intervent Radiol; 2010 Jun;27(2):111-23
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  • [Title] Embolization of musculoskeletal bone tumors.
  • Bone tumors may present as incidental findings, with pain or loss of function, or as fractures.
  • There is a broad range of indications for transarterial embolization (TAE) in primary or metastatic bone tumors: to reduce operative hemorrhagic risks, to simplify or allow more definitive surgery, or in the context of pain palliation, fever, bleeding, or hypercalcemic and other rheological factors.
  • Embolization may also increase tumor sensitivity to chemotherapy or radiation therapy.
  • The procedure itself is often complex with significant risk to adjacent structures and is usually part of a wider treatment strategy.
  • There are many options of embolic agent, techniques, and end points but all aim to devascularize the tumor.
  • Tumor types treated include vascular metastatic lesions, commonly renal cell or thyroid, particularly in locations prone to fracture; giant cell tumors; aneurysmal bone cysts; vertebral hemangiomas, osteosarcomas; arteriovenous malformations; and osteoblastomas.
  • TAE should be considered in the treatment algorithm of primary or secondary bone tumors.

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  • (PMID = 21629401.001).
  • [ISSN] 1098-8963
  • [Journal-full-title] Seminars in interventional radiology
  • [ISO-abbreviation] Semin Intervent Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3036517
  • [Keywords] NOTNLM ; Embolization / bone tumors / metastases
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56. Mahajan S, Srikant N, Boaz K, George T: Osteoblastoma of maxilla with cartilaginous matrix: review of literature and report of a case. Singapore Dent J; 2007 Dec;29(1):12-8
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  • [Title] Osteoblastoma of maxilla with cartilaginous matrix: review of literature and report of a case.
  • Osteoblastoma is a rare benign neoplasm of jaws.
  • We report a case of a recurrent osteoblastoma in the maxilla of a 34-year-old male who presented with aggressive clinical and histologic features: namely root resorption, tooth mobility, involvement of maxillary sinus, chondroid formation, host bone trapping, and lack of osteoblastic rimming.
  • A systematic review of other reported cases of osteoblastoma of jaws with a note on the recurrent cases has been put forth.
  • [MeSH-major] Cartilage / pathology. Maxillary Neoplasms / pathology. Osteoblastoma / pathology

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  • (PMID = 18472525.001).
  • [ISSN] 0377-5291
  • [Journal-full-title] Singapore dental journal
  • [ISO-abbreviation] Singapore Dent J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Singapore
  • [Number-of-references] 18
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57. Herrera Tenorio JG, Núnuez Fernández AI, Mendoza Quiroga JJ, Sesma Villalpando RA: [Benign osteoblastoma in the proximal phalanx. A case report]. Acta Ortop Mex; 2009 Sep-Oct;23(5):298-301
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  • [Title] [Benign osteoblastoma in the proximal phalanx. A case report].
  • [Transliterated title] Osteoblastoma benigno en falange proximal. Reporte de un caso.
  • The purpose of this article is to present a case of phalanx osteoblastoma.
  • We will start by saying that osteoblastoma is rare, it accounts for 1% of primary bone tumors; it is most frequent in the posterior spine, and is very unusual in the phalanges.
  • Early diagnosis is desirable due to its similarity, mainly radiologic, with other entities that result in similar bone lesions.
  • We present the case of a 39-year-old male who presented with swelling of the proximal phalanx of the 5th digit of the left hand that began one year before.
  • The histopathologic study of the tumor lesion showed that it was composed of prominent osteoblasts.
  • [MeSH-major] Bone Neoplasms. Finger Phalanges. Osteoblastoma

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  • (PMID = 20336881.001).
  • [ISSN] 2306-4102
  • [Journal-full-title] Acta ortopédica mexicana
  • [ISO-abbreviation] Acta Ortop Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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58. Saccomanni B: Osteoid osteoma and osteoblastoma of the spine: a review of the literature. Curr Rev Musculoskelet Med; 2009 Mar;2(1):65-7
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  • [Title] Osteoid osteoma and osteoblastoma of the spine: a review of the literature.
  • Osteoid osteoma and osteoblastoma are rare primary bone tumors that usually do not arise in the spine.
  • Histologically, osteoid osteoma and osteoblastoma are similar, containing osteoblasts that produce osteoid and woven bone.
  • Osteoblastoma, however, is larger, tends to be more aggressive, and can undergo malignant transformation, whereas osteoid osteoma is small, benign, and self-limited.

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  • (PMID = 19468920.001).
  • [ISSN] 1935-973X
  • [Journal-full-title] Current reviews in musculoskeletal medicine
  • [ISO-abbreviation] Curr Rev Musculoskelet Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2684956
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59. Daszkiewicz P, Roszkowski M, Barszcz S, Kuczyński D, Grajkowska W: [Osteoblastoma of the dens axis in a 14-year-old boy. A case report]. Neurol Neurochir Pol; 2005 Sep-Oct;39(5):420-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Osteoblastoma of the dens axis in a 14-year-old boy. A case report].
  • [Transliterated title] Guz zeba kregu obrotowego (osteoblastoma) u 14-letniego chłopca. Opis przypadku.
  • We present a case of osteoblastoma of C1 in a 14-year-old boy.
  • [MeSH-major] Odontoid Process. Osteoblastoma / diagnosis. Osteoblastoma / surgery. Spinal Neoplasms / diagnosis. Spinal Neoplasms / surgery

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  • (PMID = 16273469.001).
  • [ISSN] 0028-3843
  • [Journal-full-title] Neurologia i neurochirurgia polska
  • [ISO-abbreviation] Neurol. Neurochir. Pol.
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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60. Gutteck N, Mendel T, Held A, Wohlrab D: [Cervical spine osteoblastoma in children: Selective diagnostics as the basis for effective surgical management]. Orthopade; 2010 Jan;39(1):92-6
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  • [Title] [Cervical spine osteoblastoma in children: Selective diagnostics as the basis for effective surgical management].
  • [Transliterated title] Osteoblastom der Halswirbelsäule im Kindesalter: Gezielte Diagnostik als Grundlage einer erfolgreichen operativen Therapie.
  • Expansively growing cervical spine osteoblastomas are rare but can cause severe neurological damage as a result of their anatomical relationship to nerve structures.
  • Also, cerebral vessels, especially the vertebral artery in its transvertebral position, are often covered by tumor tissue.
  • In complete resection of the tumor, it is sometimes possible to retain the affected vessel.
  • This case report describes the staged diagnostic procedure and successful complete resection, retaining the affected vertebral artery, of an osteoblastoma of the 5th cervical body with massive intraspinal expansion in an 11-year-old child.
  • [MeSH-major] Cervical Vertebrae / surgery. Laminectomy / methods. Osteoblastoma / diagnosis. Osteoblastoma / surgery. Reconstructive Surgical Procedures / methods. Spinal Neoplasms / diagnosis. Spinal Neoplasms / surgery

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  • (PMID = 19763536.001).
  • [ISSN] 1433-0431
  • [Journal-full-title] Der Orthopade
  • [ISO-abbreviation] Orthopade
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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61. Wei F, Dang GT, Liu ZJ, Ma QJ, Liu XG: [Surgical factors underlying the recurrence of primary spine tumor]. Zhonghua Wai Ke Za Zhi; 2005 Feb 15;43(4):221-4
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  • [Title] [Surgical factors underlying the recurrence of primary spine tumor].
  • METHODS: From 1989 to 2002, 38 cases of primary spine tumors, including giant cell tumor, osteoblastoma, chondrosarcoma and chordoma with wide resection via a piece-meal fashion.
  • RESULTS: The study included 18 cases of giant cell tumor, 6 osteoblastoma, 6 chondrosarcoma and 8 chordoma.
  • And 71% patients had the tumor in the body and the arch simultaneously.
  • The recurrence rate of giant cell tumor was 35%, osteoblastoma 50%, chondrosarcoma 75%, chordoma 100%.
  • The recurrence rate of tumor in cervical and cervicothoracic spine was 63%, thoracic-lumbar 33%, sacrum 67%.
  • CONCLUSIONS: During the primary spinal tumor operation, that failure to get adequate exposure and full division is thought to be the cause of recurrence.
  • So the precise design before surgery and adequate exposure of the tumor in the surgery is the guarantee of wide excision.

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  • (PMID = 15842915.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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62. Combalia Aleu A, Popescu D, Pomes J, Palacin A: Long-standing pain in a 25-year-old patient with a non-diagnosed cervical osteoblastoma: a case report. Arch Orthop Trauma Surg; 2008 Jun;128(6):567-71
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  • [Title] Long-standing pain in a 25-year-old patient with a non-diagnosed cervical osteoblastoma: a case report.
  • Benign osteoblastomas are infrequent tumors, representing less than 1% of all bone tumors.
  • The spinal location accounts for 40-50% of all osteoblastomas from which only 20% are located in the cervical spine.
  • The majority of the spinal osteoblastomas arise from the posterior elements: pedicles, laminas, transverse or spinous processes.
  • We present a case report of a young male that due to the lack of specific symptoms was diagnosed of a cervical osteoblastoma 14 months after the first symptoms.
  • The tumor was located in the right C7 pedicle.
  • We then operated, resected the tumor and a posterior C6-T1 bilateral instrumentation was performed to stabilize the spine.
  • The treatment of this lesion is the complete surgical resection based on a correct preoperative planning with CT and MRI in order to define precisely the location, size and extension of the tumor.
  • [MeSH-major] Cervical Vertebrae. Osteoblastoma / diagnosis. Spinal Neoplasms / diagnosis

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  • (PMID = 17641905.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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63. Nishida K, Doita M, Kawahara N, Tomita K, Kurosaka M: Total en bloc spondylectomy in the treatment of aggressive osteoblastoma of the thoracic spine. Orthopedics; 2008 Apr;31(4):403
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  • [Title] Total en bloc spondylectomy in the treatment of aggressive osteoblastoma of the thoracic spine.
  • Osteoblastoma is an uncommon, benign osteoblastic tumor accounting for <1% of all primary bone tumors.
  • Aggressive osteoblastoma is a variant of osteoblastoma and is considered to be a borderline or intermediate osteoblastic tumor, first defined by Dorfman and Weiss in 1984.
  • As a rare tumor, its true incidence and distribution are not clearly known.
  • Treatment of osteoblastoma is complete surgical excision by either curettage or en bloc technique.
  • Recurrence is seen in 10% to 15% of cases, and aggressive osteoblastoma are more likely to recur (<or=50%).
  • Therefore, total en bloc spondylectomy constitutes the treatment of choice for recurrent aggressive osteoblastoma.
  • This article reports a rare case of recurrent aggressive osteoblastoma of the thoracic spine, successfully treated by total en bloc spondylectomy.
  • Treatment options for such a highly recurrent benign tumor are discussed.
  • [MeSH-major] Laminectomy / methods. Neoplasm Recurrence, Local / prevention & control. Osteoblastoma / surgery. Spinal Neoplasms / surgery. Thoracic Vertebrae / surgery

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  • (PMID = 19292265.001).
  • [ISSN] 0147-7447
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Cleton-Jansen AM, Anninga JK, Briaire-de Bruijn IH, Romeo S, Oosting J, Egeler RM, Gelderblom H, Taminiau AH, Hogendoorn PC: Profiling of high-grade central osteosarcoma and its putative progenitor cells identifies tumourigenic pathways. Br J Cancer; 2009 Dec 1;101(11):1909-18
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  • BACKGROUND: Osteosarcoma is the most prevalent primary malignant bone tumour in children and young adults, with poor survival in 40% of patients.
  • METHODS: Genome-wide expression profiles were generated from 25 high-grade central osteosarcoma prechemotherapy biopsies, 5 osteoblastomas, 5 mesenchymal stem cell (MSC) populations and these same MSCs differentiated into osteoblasts.
  • RESULTS: MSCs, osteoblasts, osteoblastomas and osteosarcomas clustered separately and thousands of differentially expressed genes were identified.
  • The most significantly altered pathways are involved in cell cycle regulation and DNA replication.
  • Comparing benign osteoblastomas with osteosarcomas identified cell cycle regulation as the most prominently changed pathway.
  • CONCLUSION: These results show that upregulation of the cell cycle and downregulation of Wnt signalling have an important role in osteosarcoma genesis.
  • Gene expression differences between highly malignant osteosarcoma and benign osteoblastoma involve cell cycle regulation.
  • [MeSH-major] Bone Neoplasms / pathology. Mesenchymal Stromal Cells / pathology. Neoplastic Stem Cells / pathology. Osteosarcoma / pathology
  • [MeSH-minor] Adolescent. Adult. Cell Cycle / physiology. Cell Differentiation. Cell Line, Tumor. Child. Child, Preschool. Down-Regulation. Female. Gene Expression Profiling. Humans. Male. Osteoblastoma / genetics. Osteoblastoma / metabolism. Osteoblastoma / pathology. Signal Transduction. Up-Regulation. Wnt Proteins / genetics. Wnt Proteins / metabolism. Young Adult

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  • (PMID = 19888226.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Wnt Proteins
  • [Other-IDs] NLM/ PMC2788255
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65. Elias I, Pahl MA, Zoga AC, Goins ML, Vaccaro AR: Recurrent burner syndrome due to presumed cervical spine osteoblastoma in a collision sport athlete - a case report. J Brachial Plex Peripher Nerve Inj; 2007;2:13
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  • [Title] Recurrent burner syndrome due to presumed cervical spine osteoblastoma in a collision sport athlete - a case report.
  • We present a case of a 35-year-old active rugby player presenting with a history of recurrent burner syndrome thought secondary to an osteoblastoma involving the posterior arch of the atlas.
  • Radiographically, the lesion had features typical for a large osteoid osteoma or osteoblastoma, including osseous expansion, peripheral sclerosis and bony hypertrophy, internal lucency, and even suggestion of a central nidus.

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  • (PMID = 17553154.001).
  • [ISSN] 1749-7221
  • [Journal-full-title] Journal of brachial plexus and peripheral nerve injury
  • [ISO-abbreviation] J Brachial Plex Peripher Nerve Inj
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1904218
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66. Jones AC, Prihoda TJ, Kacher JE, Odingo NA, Freedman PD: Osteoblastoma of the maxilla and mandible: a report of 24 cases, review of the literature, and discussion of its relationship to osteoid osteoma of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Nov;102(5):639-50
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  • [Title] Osteoblastoma of the maxilla and mandible: a report of 24 cases, review of the literature, and discussion of its relationship to osteoid osteoma of the jaws.
  • Osteoblastoma is a benign neoplasm of bone characterized by a proliferation of osteoblasts forming bone trabeculae set in a vascularized fibrous connective tissue stroma.
  • We report 24 examples of this neoplasm arising in the maxilla and mandible and compare the clinical and radiographic characteristics of this neoplasm to 53 previously reported examples of osteoblastoma and osteoid osteoma in the jaws.
  • Our results reveal more females reported in the new examples of osteoblastoma than in the previously reported examples of osteoblastoma and osteoid osteoma.
  • When all cases are combined, a predominant trend is observed whereby osteoblastoma occurs predominantly on the left side of the posterior mandible and is associated with pain, tenderness, and discomfort.
  • We also provide a rationale for use of the term "osteoblastoma" for any benign osteoblastic neoplasm arising in the jaws.
  • [MeSH-major] Jaw Neoplasms / pathology. Osteoblastoma / pathology. Osteoma, Osteoid / pathology

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  • (PMID = 17052641.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 60
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67. Scoccianti G, Campanacci DA, Innocenti M, Beltrami G, Capanna R: Total calcanectomy and reconstruction with vascularized iliac bone graft for osteoblastoma: a report of two cases. Foot Ankle Int; 2009 Jul;30(7):716-20
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  • [Title] Total calcanectomy and reconstruction with vascularized iliac bone graft for osteoblastoma: a report of two cases.
  • [MeSH-major] Bone Neoplasms / surgery. Calcaneus. Ilium / transplantation. Osteoblastoma / surgery. Osteotomy

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  • (PMID = 19589324.001).
  • [ISSN] 1071-1007
  • [Journal-full-title] Foot & ankle international
  • [ISO-abbreviation] Foot Ankle Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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68. Mirbagheri N, Galloway S, Iseli TA, Lyons BM: Extraosseous osteoblastoma of larynx presenting with acute airway obstruction. J Laryngol Otol; 2008 Nov;122(11):1265-8
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  • [Title] Extraosseous osteoblastoma of larynx presenting with acute airway obstruction.
  • OBJECTIVE: We report the case of an osteoblastoma of the larynx arising from the vocal fold, which presented with acute airway obstruction and cardiopulmonary arrest.
  • METHOD: The histopathological findings, differential diagnoses and a novel method of treating laryngeal osteoblastoma, using transoral laser therapy, are discussed.
  • RESULTS: Benign osteoblastoma is a rare primary bone tumour usually presenting in young patients in the spine and sacrum.
  • CONCLUSION: Osteoblastoma of the larynx is rare, and the clinical features can vary with the anatomical site of the lesion.
  • [MeSH-major] Airway Obstruction / etiology. Laryngeal Neoplasms / complications. Osteoblastoma / complications

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  • (PMID = 18289457.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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69. Rhode MG, Lucas DR, Krueger CH, Pu RT: Fine-needle aspiration of spinal osteoblastoma in a patient with lymphangiomatosis. Diagn Cytopathol; 2006 Apr;34(4):295-7
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  • [Title] Fine-needle aspiration of spinal osteoblastoma in a patient with lymphangiomatosis.
  • Diagnosis of osteoblastoma by fine-needle aspiration (FNA) is rare, as in most patients, excisional biopsy is performed.
  • We report a case of FNA diagnosis of a spinal osteoblastoma in a lymphangiomatosis patient.
  • Lesional cells exhibited plasmacytoid features, fine chromatin, smooth nuclear membranes, and binucleation, in a background of occasional osteoclastic cells, spindle cells, and osteoid matrix.
  • A cytological diagnosis of osteoblastoma was favored and confirmed with follow-up surgical biopsy.
  • We believe that this is the first case reporting an osteoblastoma diagnosed by FNA in a lymphangiomatosis patient.
  • We describe the clinical and cytological findings of osteoblastoma and its differential diagnosis.
  • [MeSH-major] Lymphangioma / pathology. Osteoblastoma / pathology. Spinal Neoplasms / pathology. Spine / pathology

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  • (PMID = 16544339.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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70. Blackwell JB, Curnow MN: Benign bone tumours in Western Australia, 1972-1996. Pathology; 2007 Dec;39(6):567-74
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  • [Title] Benign bone tumours in Western Australia, 1972-1996.
  • AIMS: To review the benign bone tumours accessioned by the Bone Tumour Registry (BTR) of Western Australia (WA) during the years 1972-1996 and to determine the incidence of the more common types.
  • RESULTS: During the 25 year period, 849 benign tumours were accessioned and incidence rates have been calculated for 86 chondromas, 68 osteoid osteomas, 47 giant cell tumours, 32 chondroblastomas, 15 periosteal chondromas and 13 chondromyxoid fibromas.
  • CONCLUSION: The BTR provides a valuable resource for the study of primary bone tumours.
  • This review has established reliable incidence rates for the six most common benign tumours.
  • Such information is rarely available for benign tumours.
  • It has also disclosed that osteoblastoma is only four times less frequent than osteosarcoma, which is five times higher than published figures from North America.
  • [MeSH-major] Bone Neoplasms / pathology. Registries

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  • (PMID = 18027260.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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71. Lin JH, Lin EY, Liu MY: Double aggressive osteoblastomas of calvarium. Br J Neurosurg; 2007 Dec;21(6):626-8
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  • [Title] Double aggressive osteoblastomas of calvarium.
  • The larger one was completely excised, first with a picture of an aggressive osteoblastoma in the pathology.
  • No other foci of osteoblastomas were detected on the whole body bone scan.
  • To our knowledge, this is the first case with double independent osteoblastomas occurring in frontal and parietal skull.
  • [MeSH-major] Frontal Bone / pathology. Osteoblastoma / pathology. Parietal Bone / pathology. Skull Neoplasms / pathology

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  • (PMID = 18071995.001).
  • [ISSN] 0268-8697
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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72. Alvares Capelozza AL, Gião Dezotti MS, Casati Alvares L, Negrão Fleury R, Sant'Ana E: Osteoblastoma of the mandible: systematic review of the literature and report of a case. Dentomaxillofac Radiol; 2005 Jan;34(1):1-8
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  • [Title] Osteoblastoma of the mandible: systematic review of the literature and report of a case.
  • Benign osteoblastoma is a bone tumour that seldom occurs in the facial bones.
  • A new case of benign osteoblastoma is presented and clinical, radiographic and microscopic aspects, as well as differential diagnosis, treatment and follow-up are discussed.
  • The importance of the correct diagnosis of this type of lesion is stressed, since it presents a clinical, radiographic and microscopic similarity to other bone lesions, including malignant tumours, which may lead the professional into conducting the case in an improper manner.
  • [MeSH-major] Mandibular Neoplasms / radiography. Osteoblastoma / radiography

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  • (PMID = 15709098.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 69
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73. Bhagat S, Sharma H, Bansal M, Reid R: Presentation and outcome of primary tumors of the patella. J Knee Surg; 2008 Jul;21(3):212-6
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  • Demographics, pathology, and outcomes of 7 patellar tumors, including 2 giant cell tumors, 2 chondroblastomas, 1 osteoid osteoma, 1 osteitis fibrosa cystica, and 1 case of myelomatous infiltration, are described.
  • One patient with chondroblastoma underwent curettage only; the second patient underwent curettage and bone grafting.
  • Both patients with giant cell tumors underwent total patellectomy.
  • Patients with osteoblastoma and osteitis fibrosa cystica underwent excision of the lesion.
  • A satisfactory outcome can be expected in the majority because of the predominantly benign nature of the lesions and straightforward operative intervention after diagnosis.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Patella

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  • (PMID = 18686483.001).
  • [ISSN] 1538-8506
  • [Journal-full-title] The journal of knee surgery
  • [ISO-abbreviation] J Knee Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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74. Aydeniz A, Erkutlu I, Altindağ O, Küçükoğlu B, Gürsoy S: Severe neck and back pain in adolescence: remember osteoblastoma. Rheumatol Int; 2010 Jul;30(9):1243-4
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  • [Title] Severe neck and back pain in adolescence: remember osteoblastoma.
  • Osteoblastoma is a rare benign tumor of the bone.
  • The tumor was resected by a spinal surgeon and histologic examination revealed osteoblastoma.
  • [MeSH-major] Osteoblastoma / pathology. Osteoblastoma / surgery. Spinal Neoplasms / pathology. Spinal Neoplasms / surgery

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  • (PMID = 19582457.001).
  • [ISSN] 1437-160X
  • [Journal-full-title] Rheumatology international
  • [ISO-abbreviation] Rheumatol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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75. Jamshidi K, Jafari D, Mazhar FN, Modarresnejad H: Osteoblastoma of the scaphoid bone - A rare case report. J Res Med Sci; 2009 Mar;14(2):135-8
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  • [Title] Osteoblastoma of the scaphoid bone - A rare case report.
  • Osteoblastoma is rarely found in the hand or wrist.
  • Review of literature revealed that only five cases of osteoblastoma have been reported in scaphoid bone.
  • This paper presents a rare case of scaphoid osteoblastoma with unusual course in a young patient and its treatment process.

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  • [Cites] Rev Chir Orthop Reparatrice Appar Mot. 2000 Feb;86(1):94-7 [10669831.001]
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  • (PMID = 21772873.001).
  • [ISSN] 1735-1995
  • [Journal-full-title] Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences
  • [ISO-abbreviation] J Res Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC3129090
  • [Keywords] NOTNLM ; Hand / osteoblastoma / scaphoid / wrist
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76. Narita T, Ishii N, Mayuzumi H, Kobayashi H, Ikeda J, Iwasaki Y: Occipitoparietal benign osteoblastoma: should entire lesion be resected when magnetic resonance images reveal wide abnormal signal intensity in surrounding bone marrow? Surg Neurol; 2005 Aug;64(2):180-3; discussion 184
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  • [Title] Occipitoparietal benign osteoblastoma: should entire lesion be resected when magnetic resonance images reveal wide abnormal signal intensity in surrounding bone marrow?
  • BACKGROUND: Benign osteoblastoma is an uncommon primary bone tumor that usually affects long bones and the vertebral column.
  • Despite the characteristically benign nomenclature of osteoblastoma, it sometimes recurs with the possibility of transforming into a malignant form after an incomplete resection.
  • However, it has not been clarified whether the adjacent bones should also be completely resected when magnetic resonance (MR) images reveal abnormal signal intensity in the bone marrow.
  • CASE DESCRIPTION: Presented in this case report is a 12-year-old boy with occipital tenderness associated with occipitoparietal bone tumor.
  • Neuroradiological studies demonstrated a solid tumor located in the occipital bone extending over the right parietal bone.
  • Magnetic resonance images further revealed abnormal signal intensity in the bone marrow of the entire occipital and bilateral parietal bones.
  • Macroscopically, the calvarial bone adjacent to the solid tumor appeared to be reddish, but it was not covering the entire area, contradicting the abnormal intensity found on the preoperative MR images.
  • Because histological examination did not clearly indicate tumor invasion at the margin of the resection site, no additional therapy was given.
  • Although MR images revealed abnormal intensity in the bone marrow of the surgical margin immediately after the operation, the intensity had been normalized by degrees and there was no evidence of recurrence during a follow-up period of 34 months.
  • This may suggest that bone marrow lesion showing abnormal intensity was edema rather than tumor invasion.
  • CONCLUSIONS: The authors conclude that total resection, including a bone marrow lesion, is not always necessary for benign osteoblastoma.
  • Macroscopic findings that show an abnormal color tone of the cortex could be a good indicator in revealing tumor activity invading bone marrow.
  • [MeSH-major] Magnetic Resonance Imaging. Occipital Bone / pathology. Osteoblastoma / pathology. Osteoblastoma / surgery. Skull Neoplasms / pathology. Skull Neoplasms / surgery
  • [MeSH-minor] Bone Marrow Neoplasms / pathology. Child. Humans. Male. Neoplasm Invasiveness. Neoplasm Staging

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  • (PMID = 16051019.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Oliveira CR, Mendonça BB, Camargo OP, Pinto EM, Nascimento SA, Latorre Mdo R, Zerbini MC: Classical osteoblastoma, atypical osteoblastoma, and osteosarcoma: a comparative study based on clinical, histological, and biological parameters. Clinics (Sao Paulo); 2007 Apr;62(2):167-74
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  • [Title] Classical osteoblastoma, atypical osteoblastoma, and osteosarcoma: a comparative study based on clinical, histological, and biological parameters.
  • OBJECTIVE: To investigate the biological behavior of classical and atypical osteoblastomas in comparison to osteosarcomas.
  • METHODS: Based on histological parameters, 30 osteoblastomas were subclassified as classical osteoblastomas (23/30) or atypical osteoblastoma (high cellularity, prominent blue osteoid, and epithelioid osteoblasts--7/30).
  • Formalin-fixed, paraffin-embedded archival tissue was immunostained for p53 and proliferation cell nuclear antigen.
  • RESULTS: The mean proliferating cell nuclear antigen indexes for classical osteoblastoma, atypical osteoblastoma, and osteosarcoma were 33%, 61%, and 79%, respectively.
  • p53 protein was detected in 4 (13%) osteoblastomas (3 of these were atypical osteoblastoma), and 4 osteosarcomas (23%) also showed p53 positivity.
  • DNA mutation performed in p53-positive cases was confirmed in exon 10 in 2 atypical osteoblastomas (2/3), 1 classical osteoblastoma (1/1), and 1 osteosarcoma (1/4).
  • Disease recurrence was correlated with p53 expression (P = 0.009), atypical subtype (P = 0.031), spiculated blue bone on histology (P = 0.018), and proliferating-cell nuclear antigen labeling index > or =40 (P = 0.015).
  • CONCLUSION: These results validate atypical osteoblastoma as an entity, with p53 and proliferation cell nuclear antigen immuno-expression closer to that of osteosarcoma than of classical osteoblastoma.
  • Proliferating cell nuclear antigen labeling index and p53 may be useful predictors of recurrence.
  • [MeSH-major] Bone Neoplasms / pathology. Genes, p53 / genetics. Mutation / genetics. Osteoblastoma / pathology. Osteosarcoma / pathology. Proliferating Cell Nuclear Antigen / analysis

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  • (PMID = 17505702.001).
  • [ISSN] 1807-5932
  • [Journal-full-title] Clinics (São Paulo, Brazil)
  • [ISO-abbreviation] Clinics (Sao Paulo)
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Proliferating Cell Nuclear Antigen
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78. Povýsil C, Kana R, Horák M: [S-100 protein positivity in osteogenic tumours and tumour-like bone forming lesions]. Cesk Patol; 2008 Jul;44(3):59-61
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  • [Title] [S-100 protein positivity in osteogenic tumours and tumour-like bone forming lesions].
  • Various osteogenic tumours and bone producing tumour-like lesions of bone were examined for S-100 protein using the immunostaining methods.
  • The positive reaction for S-100 protein of some bone cells was detected not only in osteoblastic osteosarcomas and osteoblastomas, but also in osteoplastic reactive lesions, fibrous dysplasia, Paget's disease and in the tissue of the bony callus.
  • The S-100 protein positive bone cells have to be differentiated from chondrocytes persisting in new-formed bone trabecullae.
  • Such explanation is supported by the results of our study, because we also observed intense positivity of bone cells in the reaction with monoclonal antibody against S-100A6.
  • In contrast, no staining of bone cells was detected with monoclonal antibodies against S-100 A1 and B2.
  • [MeSH-major] Bone Diseases / metabolism. Bone Neoplasms / chemistry. Ossification, Heterotopic / metabolism. S100 Proteins / analysis
  • [MeSH-minor] Bone and Bones / chemistry. Humans. Immunohistochemistry

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  • (PMID = 18783135.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / S100 Proteins
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79. Papadaki ME, Troulis MJ, Kaban LB: Advances in diagnosis and management of fibro-osseous lesions. Oral Maxillofac Surg Clin North Am; 2005 Nov;17(4):415-34
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  • Fibro-osseous lesions are benign mesenchymal skeletal tumors in which mineralized tissue, blood vessels, and giant cells in varying proportions replace normal bone.
  • Included in this group are fibrous dysplasia, cherubism, ossifying fibromas, and osteoblastoma, with fibrous dysplasia being the most common entity.
  • Because the histologic appearance does not predict the rate of growth or prognosis, treatment is based on the clinical and biologic behavior of the tumor.

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  • (PMID = 18088796.001).
  • [ISSN] 1042-3699
  • [Journal-full-title] Oral and maxillofacial surgery clinics of North America
  • [ISO-abbreviation] Oral Maxillofac Surg Clin North Am
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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80. Layadi F, Aniba K, Lmejjati M, Aït Elqadi A, Aït Benali S: [Giant osteoid osteoma of the posterior skull base. A case report and literature review]. Neurochirurgie; 2006 Jun;52(2-3 Pt 1):128-32
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  • [Title] [Giant osteoid osteoma of the posterior skull base. A case report and literature review].
  • [Transliterated title] Ostéome ostéoïde géant de l'étage postérieur de la base du crâne. A propos d'un cas et revue de la littérature.
  • BACKGROUND: Osteoid osteoma is a benign bone neoplasm which is seen in the long bones.
  • Posterior skull base osteoma is extremely rare and has been anecdotally reported.
  • OBSERVATION: We report a rare case of a large osteoid osteoma of the petro-occipital area in a 26-year-old man.
  • Cerebral MRI shows a giant lesion of the posterior cerebral fossa with destruction of the left petrous bone and the left side of the occipital bone.
  • CONCLUSION: Although benign and rare, osteoid osteoma can present with neurological deficit due to mass effect and involvement of nervous structures especially in the posterior skull base.
  • [MeSH-major] Osteoma / surgery. Skull Base Neoplasms / surgery

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  • (PMID = 16840973.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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81. Qian BP, Qiu Y, Wang B, Yu Y, Zhu ZZ, Zhu F, Ma WW: [Spontaneous spinal epidural hematoma: early recognition and clinical evaluation]. Zhonghua Wai Ke Za Zhi; 2008 Jul 1;46(13):977-80
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  • Etiological factors were noted in 9 patients, 3 with hypertension, 2 with angioma, 2 with laminar osteoblastoma, 1 with neuroblastoma, and 1 with thrombolysis treatment.

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  • (PMID = 19035196.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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82. Kandziora F, Pingel A: Posterior-anterior resection of a cervical spine osteoblastoma. Eur Spine J; 2010 Jun;19(6):1041-3
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  • [Title] Posterior-anterior resection of a cervical spine osteoblastoma.
  • [MeSH-major] Cervical Vertebrae / surgery. Neurosurgical Procedures / methods. Osteoblastoma / surgery. Spinal Neoplasms / surgery
  • [MeSH-minor] Bone Plates. Humans. Internal Fixators. Male. Middle Aged. Neck Pain / etiology. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / physiopathology. Radiography

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  • [Cites] Orthopade. 2010 Jan;39(1):92-6 [19763536.001]
  • [Cites] Eur Spine J. 2010 Jun;19(6):1044-5 [20514497.001]
  • (PMID = 20514498.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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83. O'Dwyer HM, Keogh CF, O'Connell JX, Munk PL: A case report of synchronous osteoblastoma and fibromatosis. Br J Radiol; 2008 Mar;81(963):e68-71
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  • [Title] A case report of synchronous osteoblastoma and fibromatosis.
  • Osteoblastoma is a rare bone tumour that accounts for 1% of all primary bone tumours and 3% of all benign bone tumours.
  • Osteoblastoma occurring in long bones has a predilection for the meta-diaphysis.
  • It bears a close histological resemblance to osteoid osteoma, but it is not growth limited - usually 2 cm or greater at diagnosis.
  • The term "fibromatosis" covers a broad spectrum of benign fibrous tissue proliferations.
  • To our knowledge, this is the first case report in the English literature of a patient with synchronous presentation of an osteoblastoma and fibromatosis.
  • [MeSH-major] Femoral Neoplasms / pathology. Fibroma / pathology. Neoplasms, Multiple Primary / pathology. Osteoblastoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 18270286.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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84. Al-Shaham AA, Samher AA: Cemento-ossifying fibroma of the maxilla. J Plast Surg Hand Surg; 2010 Dec;44(6):318-21
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  • [Title] Cemento-ossifying fibroma of the maxilla.
  • Despite the fact that cemento-ossifying fibromas of the maxilla may be quite large and locally aggressive, en-bloc excision is achieved by gentle blunt dissection, with the whole tumour mass peeled out from the adjacent structures.
  • In 1992 The World Health Organization adopted a new classification that included these fibromas as benign osseous tumours.
  • We present a 35-year-old woman who had a giant expanding lobular mass in the right maxilla of 5 years duration.
  • The differential diagnosis included fibrous dysplasia, osteoid osteoma, osteoblastoma, chronic sclerosing osteomyelitis, ameloblastoma, squamous cell carcinoma of the maxillary sinus, calcifying epithelial odontogenic tumour (Pindborg tumour) and calcifying odontogenic cyst (Gorlin cyst).
  • Histopathological examination confirmed a cemento-ossifying fibroma.
  • [MeSH-major] Cementoma / pathology. Fibroma, Ossifying / pathology. Maxillary Neoplasms / pathology

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  • (PMID = 21446812.001).
  • [ISSN] 2000-6764
  • [Journal-full-title] Journal of plastic surgery and hand surgery
  • [ISO-abbreviation] J Plast Surg Hand Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
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85. Folk GS, Williams SB, Foss RB, Fanburg-Smith JC: Oral and maxillofacial sclerosing epithelioid fibrosarcoma: report of five cases. Head Neck Pathol; 2007 Sep;1(1):13-20
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  • Tumor location included the infra-temporal fossa, buccal mucosa (recurrence extending into bone), anterior mandible (intraosseous primary, focally extending into soft tissue), and left parotid and submandibular gland (with metaplastic bone) regions.
  • Tumor sizes ranged from 1.0 to 5.7 cm, median 3.5 cm.
  • The spindled to primarily epithelioid tumor cells formed moderately cellular sheets and cords of irregularly contoured medium to large, round to oval, occasionally overlapping nuclei, indistinct nucleoli, wispy eosinophilic (retracting) cytoplasm, and distinctive cytoplasmic borders, embedded in osteoid-like stroma.
  • Immunohistochemically, the tumor cells were positive for vimentin, 1 case focally for CD34, whereas all cases were negative for S100 protein, keratins, EMA, desmin, and SMA.
  • One case had no recurrent/residual disease at 3 months.
  • Metastatic disease was present in 2 cases, to chest wall and lumbar/thoracic spine at 12 and 21 months, respectively.
  • One patient died of disease complications at 15 months.
  • OMFRSEF occur in adults in various locations, but with a common propensity to involve bone; there is recurrent potential and morbidity with higher grade lesions.
  • The differential diagnosis for these tumors in this site includes sclerosing carcinoma, Ewing/PNET, osteosarcoma, osteoblastoma, and benign and malignant myoepithelial salivary gland tumors.
  • The collagen, focal spindle cell features, HPC-like vasculature, and weak focal CD34 reactivity in one case might have raised a possible relationship between OMFRSEF and low grade malignant solitary fibrous tumor, but the intraosseous propensity, epithelioid features and relative lack of CD34 make this a distinctive entity.
  • [MeSH-minor] Adult. Apoptosis. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Leiomyoma / diagnosis. Male. Middle Aged. Sclerosis. Solitary Fibrous Tumors / diagnosis. Young Adult

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  • [ErratumIn] Head Neck Pathol. 2013 Mar;7(1):103
  • (PMID = 20614275.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807507
  • [Keywords] NOTNLM ; Maxillofacial / Oral / Sarcoma / Sclerosing epithelioid fibrosarcoma
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86. Li GD, Cai ZD, Zhang YQ, Gong HY, Tang H, Zhang QL: [Gene profiling of MAPK pathway in human osteosarcoma]. Zhonghua Zhong Liu Za Zhi; 2009 May;31(5):340-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Gene microarray (Human Genome U133A, Affymetrix) was used to screen the differential expression of genes involved in MAPK pathway between osteosarcoma cell lines and 3 osteoblastic cell lines.
  • Immunohistochemical technique was used to detect the expressions of ERK1/2, JNK and p38 proteins among 48 osteosarcoma and benign 24 osteoblastic tumor samples.
  • ERK, JNK and p38 form an intercoordinating network and regulate the cell proliferation, differentiation, apoptosis, invasion and migration in osteosarcoma.
  • [MeSH-major] Bone Neoplasms / genetics. Gene Expression Profiling. Mitogen-Activated Protein Kinases / metabolism. Osteosarcoma / genetics. Signal Transduction
  • [MeSH-minor] Adolescent. Adult. Aged. Cell Line, Tumor. Child. Female. Humans. JNK Mitogen-Activated Protein Kinases / metabolism. Male. Middle Aged. Mitogen-Activated Protein Kinase 1 / metabolism. Mitogen-Activated Protein Kinase 3 / metabolism. Oligonucleotide Array Sequence Analysis. Osteoblastoma / genetics. Osteoblastoma / metabolism. Osteoblastoma / pathology. Young Adult. p38 Mitogen-Activated Protein Kinases / metabolism


87. Gdoura F, Trigui M, Ellouze Z, Hamed YB, Ayadi K, Keskes H: Hamatum osteoblastoma. Orthop Traumatol Surg Res; 2010 Oct;96(6):712-6
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  • [Title] Hamatum osteoblastoma.
  • We report the case of an osteoblastoma of the hamate bone that was successfully treated by curettage.
  • This tumor is very rare in a carpal bone and only nine cases have been reported in the literature.
  • Osteoblastomas are benign, but potentially aggressive bone tumors.
  • [MeSH-major] Bone Neoplasms / surgery. Hamate Bone / surgery. Osteoblastoma / surgery
  • [MeSH-minor] Adult. Biopsy. Bone Cysts / diagnosis. Bone Cysts / pathology. Bone Cysts / surgery. Curettage. Delayed Diagnosis. Humans. Magnetic Resonance Imaging. Male. Osteolysis / diagnosis. Osteolysis / pathology. Osteolysis / surgery

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20692218.001).
  • [ISSN] 1877-0568
  • [Journal-full-title] Orthopaedics & traumatology, surgery & research : OTSR
  • [ISO-abbreviation] Orthop Traumatol Surg Res
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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88. Mankin HJ, Hornicek FJ, Ortiz-Cruz E, Villafuerte J, Gebhardt MC: Aneurysmal bone cyst: a review of 150 patients. J Clin Oncol; 2005 Sep 20;23(27):6756-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aneurysmal bone cyst: a review of 150 patients.
  • PURPOSE: We have reviewed a series of 150 aneurysmal bone cysts treated over the last 20 years.
  • RESULTS: Only one of the patients was believed to have an osteoblastoma of the spine with secondary development of an aneurysmal bone cyst, and none of the patients developed additional lesions.
  • CONCLUSION: Aneurysmal bone cysts are enigmatic lesions of unknown cause and presentation and are difficult to distinguish from other lesions.
  • [MeSH-major] Bone Cysts, Aneurysmal / pathology. Bone Cysts, Aneurysmal / surgery. Bone Transplantation / methods. Curettage / methods

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  • [CommentIn] J Clin Oncol. 2006 Jan 1;24(1):e1; author reply e2 [16382110.001]
  • (PMID = 16170183.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 45
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89. von Chamier G, Holl-Wieden A, Stenzel M, Raab P, Darge K, Girschick HJ, Beer M: Pitfalls in diagnostics of hip pain: osteoid osteoma and osteoblastoma. Rheumatol Int; 2010 Jan;30(3):395-400
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  • [Title] Pitfalls in diagnostics of hip pain: osteoid osteoma and osteoblastoma.
  • Osteoid osteoma and osteoblastoma are benign bone tumors that occur most often in adolescents and predominantly in males.
  • Typical clinical symptoms, such as reduced range of motion of adjacent joints, nocturnal bone pain and relief of pain using non-steroidal anti-inflammatory drug therapy especially in osteoid osteoma may lead to the correct diagnosis.
  • Magnetic resonance imaging is increasingly used for screening, but early findings in the course of disease might not lead to the definite diagnosis.
  • Both entities (especially osteoid osteoma) occur frequently in the area of the hip.
  • To demonstrate pitfalls in the diagnostic pathway of hip pain caused by benign bone tumors, we present two cases with osteoid osteoma and one with osteoblastoma.
  • [MeSH-major] Arthralgia / etiology. Bone Neoplasms / pathology. Diagnostic Errors / prevention & control. Hip Joint / pathology. Osteoblastoma / pathology. Osteoma, Osteoid / pathology

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  • (PMID = 19444452.001).
  • [ISSN] 1437-160X
  • [Journal-full-title] Rheumatology international
  • [ISO-abbreviation] Rheumatol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal
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90. Amirjamshidi A, Abbassioun K: Osteoblastoma of the third cervical vertebra in a 16-year-old boy: case report and review of the literature. Pediatr Neurosurg; 2010;46(5):396-401
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  • [Title] Osteoblastoma of the third cervical vertebra in a 16-year-old boy: case report and review of the literature.
  • BACKGROUND/SUBJECT: A rare case of osteoblastoma of the third cervical vertebra (C3) occurring in a 16-year-old adolescent is presented.
  • METHOD: Plain X-rays, technetium bone scanning, CT scan and MRI indicated an expansile, partially sclerotic lesion of the C3 involving the superior facet and pedicle on the right side.
  • RESULT: Even though the 18-month follow-up is still a very short interval in our case, the subject's neck pain has resolved completely and there has been no sign of tumor recurrence in the recently taken imaging.
  • To the best of our knowledge, this is the third case of C3 osteoblastoma reported in the literature, highlighting the predilection of the reported cases to occur in 14- to 16-year-old boys.
  • Long-term follow-up is needed to declare a lifelong cure of the disease.
  • [MeSH-major] Cervical Vertebrae / surgery. Osteoblastoma / surgery. Spinal Neoplasms / surgery

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  • [Copyright] Copyright © 2011 S. Karger AG, Basel.
  • (PMID = 21412027.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
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91. Bryniarska E, Srinivasan D, Oloyede D: Pathology quiz case 2. Osteoblastoma. Arch Otolaryngol Head Neck Surg; 2009 May;135(5):521, 522-3
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  • [Title] Pathology quiz case 2. Osteoblastoma.
  • [MeSH-major] Mandibular Neoplasms / pathology. Osteoblastoma / pathology

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  • (PMID = 19451478.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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92. Erlemann R: [MRI morphology of bone tumors and tumor-like lesions]. Radiologe; 2010 Jan;50(1):61-80; quiz 81
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  • [Title] [MRI morphology of bone tumors and tumor-like lesions].
  • Spin-echo sequences are mandatory at MRI for staging and characterization of bone tumors and tumor-like lesions.
  • Although many bone tumors and tumor-like lesions present similar morphology at MRI, some entities can be diagnosed with good reliability.
  • These include chondrogenic tumors, solitary and aneurysmal bone cysts, giant cell tumors, lesions containing fatty tissue and, to a certain extent, osteoid-osteomas and osteoblastomas.
  • Practical advice is given regarding when to perform a MRI study in cases of tumor suspicion.
  • Further advice is given for cases a tumor is found incidentally at a MRI study, how to modify the study and which kind of tumor may be present.
  • [MeSH-major] Bone Neoplasms / diagnosis. Image Enhancement. Image Processing, Computer-Assisted. Magnetic Resonance Imaging
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Bone Cysts / diagnosis. Bone Cysts, Aneurysmal / diagnosis. Bone and Bones / pathology. Child. Child, Preschool. Chondroma / diagnosis. Chondrosarcoma / diagnosis. Diagnosis, Differential. Female. Giant Cell Tumor of Bone / diagnosis. Giant Cell Tumor of Bone / pathology. Histiocytosis, Langerhans-Cell / diagnosis. Humans. Infant. Lipoma / diagnosis. Male. Middle Aged. Osteosarcoma / diagnosis. Sarcoma, Ewing / diagnosis. Young Adult

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  • (PMID = 19609499.001).
  • [ISSN] 1432-2102
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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93. Oommen AT, Madhuri V, Walter NM: Benign tumors and tumor-like lesions of the calcaneum: a study of 12 cases. Indian J Cancer; 2009 Jul-Sep;46(3):234-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign tumors and tumor-like lesions of the calcaneum: a study of 12 cases.
  • Benign tumors of the calcaneum are rare.
  • Cystic lesions such as simple bone cysts and aneurysmal bone cysts are commonly seen.
  • MATERIALS AND METHODS: We analyzed noninfectious, noninflammatory, benign lesions of the calcaneum seen in the Orthopedic Out Patient Department from 1991 to 2003.
  • RESULTS: Twelve benign lesions were seen in 12 patients.
  • In our series, cysts predominated, with three aneurysmal bone cysts and five simple bone cysts.
  • The other benign tumors were: one fibrous dysplasia, one vascular hamartoma, one osteoblastoma, and one chondromyxoid fibroma.
  • The bone cysts were treated by curettage, with or without bone grafting, except for one large aneurysmal bone cyst, which was treated by excision of the calcaneum.
  • CONCLUSION: The calcaneum is an uncommon site for most bone tumors, and in our series, bone cysts were the most common benign lesions.
  • Curettage and bone grafting or the use of bone substitutes can be effectively used in the treatment of symptomatic bone cysts of the calcaneum.
  • [MeSH-major] Bone Cysts / pathology. Bone Cysts, Aneurysmal / pathology. Bone Neoplasms / pathology. Calcaneus / pathology. Osteoblastoma / pathology

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  • (PMID = 19574677.001).
  • [ISSN] 0019-509X
  • [Journal-full-title] Indian journal of cancer
  • [ISO-abbreviation] Indian J Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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94. Arkader A, Dormans JP: Osteoblastoma in the skeletally immature. J Pediatr Orthop; 2008 Jul-Aug;28(5):555-60
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  • [Title] Osteoblastoma in the skeletally immature.
  • BACKGROUND: Osteoblastoma is a rare benign and sometimes locally aggressive tumor with peak incidence in the second decade.
  • METHODS: The medical records and radiographs of all children diagnosed with osteoblastoma during a 17-year period were reviewed.
  • Pain at the tumor site was present in all cases.
  • Four of the 5 patients with spine lesions had instrumented posterior spine fusion after tumor removal.
  • CONCLUSIONS: Osteoblastomas can be successfully treated with a 4-step approach.
  • [MeSH-major] Bone Neoplasms / therapy. Osteoblastoma / therapy

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  • (PMID = 18580372.001).
  • [ISSN] 0271-6798
  • [Journal-full-title] Journal of pediatric orthopedics
  • [ISO-abbreviation] J Pediatr Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Kaya A, Altay T, Sezak M, Ozturk H: Periosteal osteoblastoma of the distal femur. Acta Orthop Belg; 2009 Apr;75(2):280-5
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  • [Title] Periosteal osteoblastoma of the distal femur.
  • Periosteal osteoblastoma is a rare benign osteoblastic bone tumour located on the cortical bone.
  • We report a case of periosteal osteoblastoma located at the distal femur in a 31-year-old man.
  • Despite its rarity, periosteal osteoblastoma should be considered as a possible diagnosis together with periostitis ossificans, periosteal chondroma, periosteal osteosarcoma and parosteal osteosarcoma when confronted with a superficial bone lesion.
  • [MeSH-major] Femoral Neoplasms / diagnosis. Osteoblastoma / diagnosis. Periosteum

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  • (PMID = 19492573.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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96. Denaro V, Denaro L, Papalia R, Marinozzi A, Di Martino A: Surgical management of cervical spine osteoblastomas. Clin Orthop Relat Res; 2007 Feb;455:190-5
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  • [Title] Surgical management of cervical spine osteoblastomas.
  • The treatment of cervical spine osteoblastomas requires complex therapeutic and reconstructive strategies depending on the tumor's location, local aggressiveness, and proximity to the surrounding neurovascular structures.
  • Preoperative embolization is useful to minimize intraoperative bleeding and decrease the relapse of vascular tumors, but its role in osteoblastoma surgery is yet to be defined.
  • We asked whether preoperative embolization with marginal resection would lead to osteoblastoma recurrence, and whether marginal excision with reconstruction would improve neurologic symptoms.
  • We retrospectively analyzed a consecutive series of patients with cervical spine osteoblastoma, treated by one surgeon with a combined approach of preoperative embolization, marginal excision, and spinal reconstruction.
  • At followup, all patients showed neurologic improvement, no tumor relapse, and adequate bony healing.
  • Although we report only a small uncontrolled cohort, the data suggest preoperative embolization and a tumor-free margin are consistent with a prolonged disease-free interval or complete tumor eradication.
  • [MeSH-major] Bone Neoplasms / surgery. Cervical Vertebrae. Embolization, Therapeutic. Orthopedic Procedures / methods. Osteoblastoma / surgery

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  • (PMID = 17016229.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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97. Van Dyck P, Vanhoenacker FM, Vogel J, Venstermans C, Kroon HM, Gielen J, Parizel PM, Bloem JL, De Schepper AM: Prevalence, extension and characteristics of fluid-fluid levels in bone and soft tissue tumors. Eur Radiol; 2006 Dec;16(12):2644-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prevalence, extension and characteristics of fluid-fluid levels in bone and soft tissue tumors.
  • The purpose of this study was to determine the prevalence, extension and signal characteristics of fluid-fluid levels in a large series of 700 bone and 700 soft tissue tumors.
  • Out of a multi-institutional database, MRI of 700 consecutive patients with a bone tumor and MRI of 700 consecutive patients with a soft tissue neoplasm were retrospectively reviewed for the presence of fluid-fluid levels.
  • Of 700 patients with a bone tumor, 19 (10 male and 9 female; mean age, 29 years) presented with a fluid-fluid level (prevalence 2.7%).
  • Diagnoses included aneurysmal bone cyst (ten cases), fibrous dysplasia (two cases), osteoblastoma (one case), simple bone cyst (one case), telangiectatic osteosarcoma (one case), "brown tumor" (one case), chondroblastoma (one case) and giant cell tumor (two cases).
  • Of 700 patients with a soft tissue tumor, 20 (9 males and 11 females; mean age, 34 years) presented with a fluid-fluid level (prevalence 2.9%).
  • Diagnoses included cavernous hemangioma (12 cases), synovial sarcoma (3 cases), angiosarcoma (1 case), aneurysmal bone cyst of soft tissue (1 case), myxofibrosarcoma (1 case) and high-grade sarcoma "not otherwise specified" (2 cases).
  • In our series, the largest reported in the literature to the best of our knowledge, the presence of fluid-fluid levels is a rare finding with a prevalence of 2.7 and 2.9% in bone and soft tissue tumors, respectively.
  • Fluid-fluid levels remain a non-specific finding and can occur in a wide range of bone and soft tissue tumors, both benign and malignant.
  • Therefore, they cannot be considered diagnostic of any particular type of tumor, and the diagnosis should be made on the basis of other radiological and clinical findings.
  • [MeSH-major] Body Fluids / metabolism. Bone Neoplasms / pathology. Magnetic Resonance Imaging / methods. Soft Tissue Neoplasms / pathology

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  • (PMID = 16612549.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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98. Moore T, McLain RF: Image-guided surgery in resection of benign cervicothoracic spinal tumors: a report of two cases. Spine J; 2005 Jan-Feb;5(1):109-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Image-guided surgery in resection of benign cervicothoracic spinal tumors: a report of two cases.
  • BACKGROUND CONTEXT: Osseous spinal tumors are an uncommon cause of persistent axial pain and muscle spasm, but even benign lesions may grow to cause deformity or neurological signs.
  • Traditional treatment approaches to resection can be debilitating even when the tumor is benign.
  • PURPOSE: Emerging technologies allow surgeons to diagnose and treat osseous neoplasms while minimizing the collateral damage caused by surgical exposure and tumor excision.
  • STUDY DESIGN: Technical considerations are presented through two cases of benign osseous neoplasm occurring in the cervicothoracic spine of competitive athletes, demonstrating the meth-ods used to provide effective treatment while maintaining maximal functional capacity.
  • METHODS: Stereotactic imaging and intraoperative guidance was used as an adjunct to tumor care in these patients.
  • Used in combination with minimally invasive, microsurgical techniques,stereotactic guidance localized and verified excision margins of benign vertebral lesions, minimizing soft tissue trauma and collateral damage.
  • CONCLUSIONS: Image guidance can accurately localize and guide excision of benign vertebral lesions while minimizing soft tissue trauma and collateral damage, allowing patients a rapid and complete return to high-demand function.
  • [MeSH-major] Osteoblastoma / surgery. Osteoma, Osteoid / surgery. Spinal Neoplasms / surgery. Surgery, Computer-Assisted / methods

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  • (PMID = 15739278.001).
  • [ISSN] 1529-9430
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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99. Kaner T, Sasani M, Oktenoglu T, Aydin S, Ozer AF: Osteoid osteoma and osteoblastoma of the cervical spine: the cause of unusual persistent neck pain. Pain Physician; 2010 Nov-Dec;13(6):549-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osteoid osteoma and osteoblastoma of the cervical spine: the cause of unusual persistent neck pain.
  • BACKGROUND: The most important symptom in patients with osteoid osteoma and osteoblastoma is a resistant localized neck pain and stiffness in the spine.
  • OBJECTIVE: To evaluate and analyze 6 cases of osteoid osteoma and osteoblastoma of the cervical spine that were surgically treated over a 7-year period and to emphasize the unusual persistent neck pain associated with osteoid osteoma and osteoblastoma of the cervical spine.
  • METHODS: Six patients, 3 male and 3 female, with a mean age of 21 years (range 16-31) diagnosed with osteoid osteoma or osteoblastoma during 2003 to 2009 were analyzed retrospectively.
  • Three patients had osteoid osteoma (2 female and one male), and 3 patients had osteoblastoma (one female and 2 male).
  • Two male patients had recurrent osteoblastoma.
  • The most common symptom was local neck pain in the region of the tumor.
  • Among all patients, only one patient, who had osteoblastoma, had neurological deficits (right C5-C6 root symptoms).
  • Two patients underwent only tumor resection, one patient underwent tumor resection and fusion, and the other 3 patients underwent tumor resection, fusion and spinal instrumentation.
  • There was no tumor recurrence during the follow-up period.
  • CONCLUSION: Surgical treatment of osteoid osteoma and osteoblastoma of the spine has been standardized.
  • The most common symptom of osteoid osteoma and osteoblastoma of the cervical spine is local persistent neck pain in the region of the tumor.
  • [MeSH-major] Bone Neoplasms / pathology. Cervical Vertebrae / pathology. Neck Pain / etiology. Neck Pain / pathology. Osteoblastoma / pathology. Osteoma, Osteoid / pathology


100. Khin YT, Peh WC, Lee VK, Teo HE, Ng SB, Nathan SS: Aggressive osteoblastoma of the proximal humerus. Singapore Med J; 2009 Jan;50(1):e1-4
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  • [Title] Aggressive osteoblastoma of the proximal humerus.
  • Bone scintiscan showed solitary marked uptake.
  • The final diagnosis was osteoblastoma with aggressive features.
  • Osteoblastoma is a relatively rare benign tumour that typically occurs in the posterior elements of the vertebral column.
  • The humerus is a very rare site of disease in the appendicular skeleton, and poses a diagnostic dilemma which implicates the possibility of osteogenic sarcoma.
  • [MeSH-major] Bone Neoplasms / diagnosis. Humerus. Osteoblastoma / diagnosis

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  • (PMID = 19224061.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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