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1. Bahrami A, Truong LD, Shen SS, Krishnan B: Synchronous renal and adrenal masses: an analysis of 80 cases. Ann Diagn Pathol; 2009 Feb;13(1):9-15
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  • [Title] Synchronous renal and adrenal masses: an analysis of 80 cases.
  • Synchronous renal and adrenal masses are uncommon.
  • Although adrenal masses in the context of renal cell carcinoma (RCC) are often suspected as metastasis, other adrenal lesions with different therapeutic and prognostic implications may coexist with RCC.
  • In a retrospective review of 550 radical nephrectomies with ipsilateral adrenalectomy, 80 cases of coexisting renal and adrenal masses were identified.
  • The renal masses included 76 RCCs, 3 oncocytomas, and 1 malignant pheochromocytoma of adrenal gland involving the kidney.
  • Although the gross pathologic impression of adrenal masses in the presence of RCC was metastasis, on histologic examination, 56% of them were found to be benign lesions (mostly adrenal adenoma/hyperplasia), whereas malignant involvement from RCC was seen in 43%.
  • The benign and malignant nature of the adrenal lesions in the context of RCC could not be discriminated based on the size of adrenal mass.
  • Rare unusual combinations of renal and adrenal lesions such as RCC and adrenal histoplasmosis, RCC and adrenal myelolipoma, renal oncocytoma, and adrenal pheochromocytoma are also described.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Adrenal Glands / pathology. Carcinoma, Renal Cell / pathology. Kidney / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / surgery. Adrenalectomy. Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Staging. Nephrectomy. Pheochromocytoma / pathology. Pheochromocytoma / surgery. Retrospective Studies

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  • (PMID = 19118776.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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2. Picken MM: Editorial comment from Dr Picken to Molecular pathology of renal oncocytoma: a review. Int J Urol; 2010 Jul;17(7):613-4
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  • [Title] Editorial comment from Dr Picken to Molecular pathology of renal oncocytoma: a review.
  • [MeSH-major] Adenoma, Oxyphilic. Kidney Neoplasms

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  • [CommentOn] Int J Urol. 2010 Jul;17(7):602-12 [20590944.001]
  • (PMID = 20590946.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] Australia
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3. Anastasiadis A, Dimitriadis G, Radopoulos D: Incidental giant renal oncocytoma: a case report. J Med Case Rep; 2010;4:358
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  • [Title] Incidental giant renal oncocytoma: a case report.
  • INTRODUCTION: Large renal oncocytomas are not very rare entities.
  • The tumor was incidentally diagnosed and, based on the preoperative clinical and radiographic findings, was therefore considered to be a renal cell carcinoma.
  • CASE PRESENTATION: A 48-year-old Caucasian diabetic man had an abdominal ultrasound for chronic abdominal discomfort, which revealed a large mass on the left kidney.
  • A magnetic resonance imaging scan was performed with no evidence of renal vein or caval thrombus or embolus.
  • A radical nephrectomy was performed through a left flank intercostal incision and the pathology diagnosed renal oncocytoma.
  • CONCLUSION: Several reports have characterised this essentially benign renal histiotype, which represents 5% to 7% of all solid renal masses.
  • Unfortunately, most renal oncocytomas cannot be differentiated from malignant renal cell carcinomas by clinical or radiographic criteria.
  • We report on, to the best of our knowledge, the fourth largest lesion of this type of renal pathology.

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  • (PMID = 21059248.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2990760
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4. Fiske J, Patel R, Kau E, Pappas JG, Garcia RA, Taneja SS: Multifocal renal oncocytoma in a patient with Von Hippel-Lindau mutation. Urology; 2005 Dec;66(6):1320
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  • [Title] Multifocal renal oncocytoma in a patient with Von Hippel-Lindau mutation.
  • Von Hippel-Lindau disease (VHL) is a rare genetic disease with a lifetime risk of clear cell renal cell carcinoma in approximately 70% of cases.
  • We present a case of a 63-year-old man with bilateral, multifocal renal masses.
  • Pathology of all renal masses revealed oncocytoma.
  • To our knowledge, we describe the first reported case of multiple renal oncocytomas in a male patient with a germline VHL mutation.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Kidney Neoplasms / genetics. von Hippel-Lindau Disease / genetics


5. Badmus TA, Adesunkanmi AR, Agbakwuru CA, Salako AA, Uhunmwagho O, Eziyi AK: Giant renal oncocytoma masquerading as infiltrating renal cell carcinoma: case report and literature review. Cent Afr J Med; 2006 Jan-Feb;52(1-2):16-9
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  • [Title] Giant renal oncocytoma masquerading as infiltrating renal cell carcinoma: case report and literature review.
  • Renal oncocytomas (RO) are tumours containing a population of cells with highly differentiated eosinophilic granular cytoplasm, extremely rich in mitochondria.
  • It is estimated they account for about 3 to 7% of all solid renocortical tumours that were previously regarded as renal cell carcinoma.
  • Based on their clinical behaviour and distinct pathologic features they are now regarded as benign renal tumours, often less than 5cm in diameter.
  • We present a case of giant renal oncocytoma in a patient with synchronous bladder tumour, with pre-operative clinical, urographic and ultrasound features of locally advanced renal cell carcinoma (RCC).
  • Findings at surgery included huge right renal tumour with infiltration to the duodenum; hepatic colic flexure; gall bladder; liver capsule and the greater omentum with small indurations at the base of the bladder.
  • There was no tumour extension to the renal vein, no peritoneal seedling, no nodal metastasis and no ascites.
  • In view of the difficulties at establishing pre-operative diagnosis in this disease and because nephron-sparing surgery is curative, especially for the well-circumscribed tumours, RO should be considered in the management of patients with features of infiltrating RCC.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Kidney Neoplasms / diagnosis
  • [MeSH-minor] Carcinoma, Renal Cell / diagnosis. Diagnosis, Differential. Female. Humans. Middle Aged


6. Alamara C, Karapanagiotou EM, Tourkantonis I, Xyla V, Maurer CC, Lykourinas M, Pandha H, Syrigos KN: Renal oncocytoma: a case report and short review of the literature. Eur J Intern Med; 2008 Nov;19(7):e67-9
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  • [Title] Renal oncocytoma: a case report and short review of the literature.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Kidney Neoplasms / pathology

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  • (PMID = 19013370.001).
  • [ISSN] 1879-0828
  • [Journal-full-title] European journal of internal medicine
  • [ISO-abbreviation] Eur. J. Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 14
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7. Shakarchi JA, Wharton I, Youssef A, Anderson P: Giant renal oncocytoma. Radiol Case Rep; 2009;4(3):307
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  • [Title] Giant renal oncocytoma.
  • We present the case of a 70-year-old male who presented with a large lesion in the right kidney, which was noticed on ultrasonography.
  • CT confirmed the large tumor, and both clinical and radiological findings raised suspicion of a renal cell carcinoma.

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  • (PMID = 27307826.001).
  • [ISSN] 1930-0433
  • [Journal-full-title] Radiology case reports
  • [ISO-abbreviation] Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC4897999
  • [Keywords] NOTNLM ; CT, computed tomography / MRI, magnetic resonance imaging
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8. Osunkoya AO, Cohen C, Lawson D, Picken MM, Amin MB, Young AN: Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. Hum Pathol; 2009 Feb;40(2):206-10
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  • [Title] Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.
  • In a recent oligonucleotide microarray study, we identified claudin-7 and claudin-8 as candidate markers to distinguish chromophobe renal cell carcinoma from other renal tumors, including oncocytoma.
  • Distinction of these lesions can be difficult by light microscopy but is clinically important because chromophobe renal cell carcinoma has malignant biological potential, whereas renal oncocytoma is benign.
  • Claudin-7 and claudin-8 expression was studied by immunohistochemistry in 11 chromophobe renal cell carcinomas and 17 oncocytomas using formalin-fixed paraffin-embedded tissue sections of tumor with adjacent nonneoplastic kidney.
  • Specificity was verified by negative control reactions without primary antibody and appropriate membranous staining patterns in positive control tissues (colon carcinoma and adjacent nonneoplastic kidney).
  • Claudin-7 protein was expressed in a membranous pattern in 10 of 11 chromophobe renal cell carcinomas and 4 of 17 oncocytomas (P < .01).
  • Claudin-8 was expressed in multiple patterns: In oncocytoma, 11 of 17 cases showed cytoplasmic, 4 of 17 membranous, and 2 of 17 negative reactions.
  • In chromophobe renal cell carcinoma, 0 of 11 cases showed cytoplasmic, 3 of 11 membranous, and 8 of 11 negative reactions (P < .01).
  • The immunohistochemical pattern of membranous claudin-7 and negative claudin-8 was seen in 7 of 11 chromophobe renal cell carcinomas and 1 of 17 oncocytomas (63% sensitivity, 84% specificity, 88% positive predictive value for chromophobe renal cell carcinoma).
  • Negative claudin-7 and cytoplasmic claudin-8 were observed in 10 of 17 oncocytomas and 0 of 11 chromophobe renal cell carcinomas (59% sensitivity, 100% specificity and positive predictive value for oncocytoma).
  • The distal nephron proteins claudin-7 and claudin-8 have potential use as immunohistochemical biomarkers in the differential diagnosis of chromophobe renal cell carcinoma and oncocytoma.
  • Expression of claudin-7 and claudin-8 may reflect the relationship of chromophobe renal cell carcinoma and oncocytoma to intercalated cells of the cortical collecting duct.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Membrane Proteins / biosynthesis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Claudins. Diagnosis, Differential. Humans. Immunohistochemistry. Sensitivity and Specificity


9. Mai KT, Bicamumpaka C, Robertson SJ, Marginean CE, Belanger EC: Oncocytic renal cell carcinoma with immunohistochemical properties of renal oncocytoma. Pathol Res Pract; 2009;205(2):119-24
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  • [Title] Oncocytic renal cell carcinoma with immunohistochemical properties of renal oncocytoma.
  • Renal oncocytoma (RO) is a characteristic benign renal tumor.
  • With recent advances in immunohistochemistry, RO can be distinguished from other renal neoplasms with routine stains and with the aid of immunostaining.
  • We report two cases of renal neoplasms with similar histopathological appearances.
  • They were characterized by oncocytic cytoplasm, numerous intra-cytoplasmic vacuoles, uniform round to oval hyperchromatic nuclei with remarkably thick nuclear membranes and prominent nucleoli.
  • The tumor cells were closely packed and disposed in an alveolar pattern.
  • The cells were non-reactive for renal cell carcinoma (RCC) antigen, vimentin, S100, and neuroendocrine markers.
  • One tumor showed lymph node metastasis.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Male. Middle Aged


10. Li L, Yao JL, di Sant'Agnese PA, Bourne PA, Picken MM, Young AN, Shen SS, Huang J: Expression of claudin-7 in benign kidney and kidney tumors. Int J Clin Exp Pathol; 2008;1(1):57-64
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  • [Title] Expression of claudin-7 in benign kidney and kidney tumors.
  • Expression of claudin-7 was increased in chromophobe renal cell carcinoma in a recent oligonucleotide microarray study.
  • We studied the expression of claudin-7 in benign and neoplastic kidneys by immunohistochemical staining.
  • Chromophobe renal cell carcinoma was positive for claudin-7 expression in 100% (36/36) of cases, while papillary renal cell carcinoma, oncocytoma and clear cell renal cell carcinoma were positive in 90% (71/80), 45% (21/47) and 7% (7/98) of the cases, respectively.
  • Differential expression of Claudin-7 in different types of renal cell neoplasms can be useful in their differential diagnosis, particularly when used in a panel of markers.
  • In addition, results from this study support previous reports of distal nephron origin for chromophobe renal cell carcinoma and oncocytoma.
  • The data also suggest that, as far as claudin-7 expression is concerned, papillary renal cell carcinoma may be more closely related to the distal nephron, rather than the proximal nephron.

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  • (PMID = 18784823.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2480537
  • [Keywords] NOTNLM ; chromophobe / claudin-7 / clear cell / kidney / neoplasm / oncocytoma / papillary
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11. Gasparre G, Hervouet E, de Laplanche E, Demont J, Pennisi LF, Colombel M, Mège-Lechevallier F, Scoazec JY, Bonora E, Smeets R, Smeitink J, Lazar V, Lespinasse J, Giraud S, Godinot C, Romeo G, Simonnet H: Clonal expansion of mutated mitochondrial DNA is associated with tumor formation and complex I deficiency in the benign renal oncocytoma. Hum Mol Genet; 2008 Apr 1;17(7):986-95
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  • [Title] Clonal expansion of mutated mitochondrial DNA is associated with tumor formation and complex I deficiency in the benign renal oncocytoma.
  • Here we show a benign tumor type in which mtDNA mutations that lead to complex I (CI) enzyme deficiency are found in all tumors and are the only genetic alteration detected.
  • Actually renal oncocytomas are homogeneous tumors characterized by dense accumulation of mitochondria and we had found that they are deficient in electron transport chain complex I (CI, NADH-ubiquinone oxidoreductase).
  • [MeSH-major] Adenoma, Oxyphilic / genetics. DNA, Mitochondrial / genetics. Electron Transport Complex I / genetics. Kidney Neoplasms / genetics

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  • (PMID = 18156159.001).
  • [ISSN] 1460-2083
  • [Journal-full-title] Human molecular genetics
  • [ISO-abbreviation] Hum. Mol. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Mitochondrial; 0 / Electron Transport Chain Complex Proteins; 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / RNA, Messenger; EC 1.6.5.3 / Electron Transport Complex I; EC 1.6.99.3 / NADH Dehydrogenase; EC 2.3.3.1 / Citrate (si)-Synthase; EC 2.7.7.- / POLG protein, human; EC 2.7.7.7 / DNA-Directed DNA Polymerase; IY9XDZ35W2 / Glucose
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12. Shriki J, Murthy V, Brown J: Renal oncocytoma on 1-11C acetate positron emission tomography: Case report and literature review. Mol Imaging Biol; 2006 Jul-Aug;8(4):208-11
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  • [Title] Renal oncocytoma on 1-11C acetate positron emission tomography: Case report and literature review.
  • Renal oncocytomas are uncommon tumors of the renal collecting duct.
  • Although generally benign, these tumors pose a diagnostic and therapeutic dilemma in that they can not be differentiated noninvasively from renal cell carcinomas.
  • The study demonstrated a nodule at the inferior pole of the right kidney with more uptake than the remainder of the kidney.
  • Upon resection, this nodule was determined to be an oncocytoma.
  • To our knowledge, this marks the first report of the 1-11C acetate PET scan appearance of a renal oncocytoma Possible mechanisms for increased uptake include dysfunctional, but up-regulated oxidative phosphorylation or uptake through lipid biosynthesis pathways.
  • [MeSH-major] Adenoma, Oxyphilic / diagnostic imaging. Kidney Neoplasms / diagnostic imaging. Positron-Emission Tomography

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  • (PMID = 16791747.001).
  • [ISSN] 1536-1632
  • [Journal-full-title] Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging
  • [ISO-abbreviation] Mol Imaging Biol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbon Radioisotopes
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13. Akbulut S, Senol A, Cakabay B, Sezgin A: Giant renal oncocytoma: a case report and review of the literature. J Med Case Rep; 2010;4:52
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  • [Title] Giant renal oncocytoma: a case report and review of the literature.
  • INTRODUCTION: Renal oncocytomas are benign neoplasms derived from cells of the distal renal tubule, and comprise 5% to 7% of primary renal neoplasms.
  • In this case report, we present a case of a patient with a giant oncocytoma arising from her left kidney.
  • Computed tomography revealed a mass with regular outlines, measuring 18 x 11 x 12 cm, associated with the left kidney, and causing marked hydroureteronephrosis.
  • The immunohistopathology of the mass was consistent with renal oncocytoma.
  • CONCLUSION: To the best of our knowledge, this is the second largest renal oncocytoma described in the English language literature.
  • This is also the first reported giant oncocytoma that presented during pregnancy.

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  • (PMID = 20205900.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2827435
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14. Brunelli M, Eble JN, Zhang S, Martignoni G, Delahunt B, Cheng L: Eosinophilic and classic chromophobe renal cell carcinomas have similar frequent losses of multiple chromosomes from among chromosomes 1, 2, 6, 10, and 17, and this pattern of genetic abnormality is not present in renal oncocytoma. Mod Pathol; 2005 Feb;18(2):161-9
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  • [Title] Eosinophilic and classic chromophobe renal cell carcinomas have similar frequent losses of multiple chromosomes from among chromosomes 1, 2, 6, 10, and 17, and this pattern of genetic abnormality is not present in renal oncocytoma.
  • That chromophobe renal cell carcinoma has an uncommon eosinophilic variant has been recognized for more than a decade.
  • In sections stained with hematoxylin and eosin, the eosinophilic variant of chromophobe renal cell carcinoma and renal oncocytoma are similar in appearance.
  • While it is well established that chromophobe renal cell carcinoma and renal oncocytoma have different patterns of genetic anomalies, little is known of the genetics of the eosinophilic variant of chromophobe renal cell carcinoma.
  • This study was undertaken to elucidate the genetic lesions of eosinophilic chromophobe renal cell carcinoma and to compare them with those found in classic chromophobe renal cell carcinoma and in renal oncocytoma.
  • A total of 29 renal neoplasms--nine eosinophilic chromophobe renal cell carcinomas, 10 classic chromophobe renal cell carcinomas, and 10 oncocytomas--were investigated by fluorescence in situ hybridization on 5 microm paraffin-embedded tissue sections with centromeric probes for chromosomes 1, 2, 6, 10, and 17.
  • Signals were counted in 100-200 neoplastic nuclei from each tumor.
  • Chromophobe renal cell carcinomas frequently showed loss of chromosomes 1 (70% of classic, 67% of eosinophilic), 2 (90% classic, 56% eosinophilic), 6 (80% classic, 56% eosinophilic), 10 (60% classic, 44% eosinophilic), and 17 (90% classic, 78% eosinophilic); Among the classic chromophobe renal cell carcinomas, only one had no loss of any of the chromosomes, while 50% had loss of all five chromosomes.
  • Among the eosinophilic chromophobe renal cell carcinomas, one of nine had no loss and 44% had loss of all five chromosomes.
  • One oncocytoma had loss of chromosome 1.
  • In conclusion, losses of chromosomes 1, 2, 6, 10, and 17 are frequent in both eosinophilic and classic chromophobe renal cell carcinomas.
  • Loss of chromosome 1 occurs occasionally in oncocytoma but losses of chromosomes 2, 6, 10, and 17 are not found in oncocytomas.
  • When the differential diagnostic problem is oncocytoma vs eosinophilic chromophobe renal cell carcinoma, detection of losses of chromosomes 2, 6, 10, or 17 effectively excludes the diagnosis of oncocytoma and supports the diagnosis of chromophobe renal cell carcinoma.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Renal Cell / pathology. Chromosome Aberrations. Kidney Neoplasms / pathology

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  • (PMID = 15467713.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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15. Feriozzi S, Giannakakis K, Ranalli TV, Pofi E, Gomes V, Ancarani E: Renal oncocytoma associated with necrotizing glomerulonephritis. Ren Fail; 2006;28(2):181-3
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  • [Title] Renal oncocytoma associated with necrotizing glomerulonephritis.
  • A case of renal oncocytoma associated with focal segmental necrotizing glomerulonephritis is described.
  • The patient showed haematuria, mild proteinuria and arterial hypertension; the diagnosis was made after right nephrectomy performed because of the presence of a renal mass.
  • Our case is the first reported in which the removal of renal oncocytoma is not followed by the disappearance of renal symptoms, as currently reported in literature, suggesting that the two diseases are not always related.
  • [MeSH-major] Adenoma, Oxyphilic / complications. Glomerulosclerosis, Focal Segmental / complications. Kidney Neoplasms / complications


16. Adley BP, Gupta A, Lin F, Luan C, Teh BT, Yang XJ: Expression of kidney-specific cadherin in chromophobe renal cell carcinoma and renal oncocytoma. Am J Clin Pathol; 2006 Jul;126(1):79-85
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  • [Title] Expression of kidney-specific cadherin in chromophobe renal cell carcinoma and renal oncocytoma.
  • Kidney-specific cadherin (Ksp-cad) recently was proposed to differentiate chromophobe renal cell carcinoma (RCC) from oncocytoma based on a finding of Ksp-cad expression in 97% of chromophobe RCCs but only 3% of oncocytomas.
  • We attempted to evaluate Ksp-cad expression in renal tumors using expression microarrays and immunohistochemical analysis.
  • Ksp-cad messenger RNA (mRNA) levels were examined in 158 renal tumors, including 15 chromophobe RCCs and 15 oncocytomas.
  • Immunohistochemical analysis was performed on tissue microarrays containing 125 renal tumors, including 36 chromophobe RCCs and 41 oncocytomas.
  • Ksp-cad mRNA compared with normal kidney tissue was 89% in chromophobe RCC and 64% in oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / metabolism. Cadherins / metabolism. Carcinoma, Renal Cell / metabolism. Kidney Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Immunoenzyme Techniques. Oligonucleotide Array Sequence Analysis. RNA, Messenger / metabolism. Retrospective Studies


17. Taouli B, Thakur RK, Mannelli L, Babb JS, Kim S, Hecht EM, Lee VS, Israel GM: Renal lesions: characterization with diffusion-weighted imaging versus contrast-enhanced MR imaging. Radiology; 2009 May;251(2):398-407
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  • [Title] Renal lesions: characterization with diffusion-weighted imaging versus contrast-enhanced MR imaging.
  • PURPOSE: To compare the diagnostic performance of diffusion-weighted (DW) magnetic resonance (MR) imaging with that of contrast material-enhanced (CE) MR imaging and to assess the performance of these examinations combined for the characterization of renal lesions, with MR follow-up and histopathologic analysis as the reference standards.
  • One hundred nine renal lesions in 64 patients (46 men, 18 women; mean age, 60.7 years) were evaluated with CE MR imaging and breath-hold DW imaging performed with various b values.
  • Renal lesions were characterized with use of CE MR criteria, and apparent diffusion coefficients (ADCs) were measured.
  • The ADCs of benign and malignant lesions were compared at Mann-Whitney testing.
  • Receiver operating characteristic (ROC) analysis was performed to assess the accuracy of DW imaging and CE MR imaging in the diagnosis of renal cell carcinoma (RCC).
  • RESULTS: The 109 renal lesions--81 benign lesions and 28 RCCs--had a mean diameter of 4.2 cm +/- 2.5 (standard deviation).
  • The mean ADC for RCCs (1.41 x 10(-3) mm(2)/sec +/- 0.61) was significantly lower (P < .0001) than that for benign lesions (2.23 x 10(-3) mm(2)/sec +/- 0.87) at DW imaging performed with b values of 0, 400, and 800 sec/mm(2).
  • At a cutoff ADC of less than or equal to 1.92 x 10(-3) mm(2)/sec, the area under the ROC curve (AUC), sensitivity, and specificity of DW imaging for the diagnosis of RCCs (excluding angiomyolipomas) were 0.856, 86%, and 80%, respectively.
  • The AUC for the DW imaging-based diagnosis of solid RCC versus oncocytoma was 0.854.
  • CONCLUSION: DW imaging can be used to characterize renal lesions; however, compared with CE MR imaging, it is less accurate.
  • [MeSH-major] Diffusion Magnetic Resonance Imaging / methods. Gadolinium DTPA. Image Enhancement / methods. Kidney Neoplasms / diagnosis

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  • (PMID = 19276322.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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18. Prager GW, Poettler M, Schmidinger M, Mazal PR, Susani M, Zielinski CC, Haitel A: CD98hc (SLC3A2), a novel marker in renal cell cancer. Eur J Clin Invest; 2009 Apr;39(4):304-10
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  • [Title] CD98hc (SLC3A2), a novel marker in renal cell cancer.
  • Especially in renal cell cancer (RCC), tyrosine kinase-inhibitors have been established as useful and highly effective therapy.
  • RESULTS: We found increased CD98hc expression in different types of malign RCCs, among them clear cell (cc)RCC, papillary (p)RCC and chromophobe (ch)RCC, but lack of expression in the benign renal oncocytoma.
  • [MeSH-major] Antigens, CD98 Heavy Chain / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis

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  • (PMID = 19292886.001).
  • [ISSN] 1365-2362
  • [Journal-full-title] European journal of clinical investigation
  • [ISO-abbreviation] Eur. J. Clin. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD98 Heavy Chain; 0 / Biomarkers, Tumor
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19. Saillant J, Fontana L, Biat I, Boudet G, Maublant C, Chamoux A: Report of three cases of renal oncocytoma in the same French chemical industrial factory. J Occup Environ Med; 2009 Oct;51(10):1113-5
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  • [Title] Report of three cases of renal oncocytoma in the same French chemical industrial factory.

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  • (PMID = 19820548.001).
  • [ISSN] 1536-5948
  • [Journal-full-title] Journal of occupational and environmental medicine
  • [ISO-abbreviation] J. Occup. Environ. Med.
  • [Language] ENG
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] WD06X94M2D / Vinyl Chloride
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20. Abrahams NA, Tamboli P: Oncocytic renal neoplasms: diagnostic considerations. Clin Lab Med; 2005 Jun;25(2):317-39, vi
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  • [Title] Oncocytic renal neoplasms: diagnostic considerations.
  • Advances in our understanding of renal neoplasia have resulted in recognition of numerous tumors that are composed predominantly of cells with abundant eosinophilic cytoplasm.
  • This article discusses the features of renal oncocytoma (including oncocytosis), chromophobe renal cell carcinoma (RCC), and clear cell RCC; explores the relationship between renal oncocytoma and chromophobe RCC; briefly discusses other tumors with abundant eosinophilic cytoplasm; and emphasizes the differential diagnosis of such tumors.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Eosinophils / pathology. Humans. Neoplastic Syndromes, Hereditary / pathology. Proteins / genetics. Proto-Oncogene Proteins. Tumor Suppressor Proteins

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  • (PMID = 15848739.001).
  • [ISSN] 0272-2712
  • [Journal-full-title] Clinics in laboratory medicine
  • [ISO-abbreviation] Clin. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / FLCN protein, human; 0 / Proteins; 0 / Proto-Oncogene Proteins; 0 / Tumor Suppressor Proteins
  • [Number-of-references] 98
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21. Adley BP, Papavero V, Sugimura J, Teh BT, Yang XJ: Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma. Anal Quant Cytol Histol; 2006 Aug;28(4):228-36
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  • [Title] Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma.
  • STUDY DESIGN: CK7 and parvalbumin mRNA expression levels in 23 oncocytomas and 32 chromophobe renal cell carcinomas (RCCs) were examined using gene expression microarrays.
  • CONCLUSION: Both mRNA and protein expression levels of CK7 appear significantly higher in chromophobe RCC compared to oncocytoma (p < 0.001).
  • Our study provides further evidence that CK7 and parvalbumin immunostains may be useful in differentiating oncocytoma from chromophobe RCC in problematic cases.
  • Negative or patchy staining (< 50% cells) for CK7 and/or parvalbumin strongly favors the diagnosis of oncocytoma.


22. Jaff A, Molinié V, Mellot F, Guth A, Lebret T, Scherrer A: Evaluation of imaging-guided fine-needle percutaneous biopsy of renal masses. Eur Radiol; 2005 Aug;15(8):1721-6
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  • [Title] Evaluation of imaging-guided fine-needle percutaneous biopsy of renal masses.
  • To evaluate the utility of imaging-guided fine-needle percutaneous biopsy of renal masses, we conducted a prospective analysis of our imaging-guided procedures from January 1999 to February 2003.
  • The mean tumor size was 33 mm.
  • Biopsy findings were positive for malignancy in 31 cases; histologic diagnoses included renal cell carcinoma (n=23), transitional cell carcinoma (n=5), and metastasis (n=3).
  • Biopsy revealed 15 benign diagnoses: oncocytoma (n=6), hemorrhagic renal cyst (n=3), chronic nephritis (n=3), angiomyolipoma (n=2), and mycotic renal abscess (n=1).
  • The average follow-up period for patients with benign diagnoses was 16 months.
  • Biopsy results showed normal renal parenchyma in eight of 54 procedures, all of which had recuperated by subsequent biopsies.
  • Imaging-guided percutaneous core biopsy is a safe and accurate method for the evaluation of renal masses.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Kidney Diseases / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Kidney Neoplasms / diagnosis. Kidney Neoplasms / diagnostic imaging. Male. Middle Aged. Tomography, X-Ray Computed. Ultrasonography

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  • [CommentIn] Eur Radiol. 2006 Aug;16(8):1857 [16395535.001]
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  • (PMID = 15627185.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
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23. Breda A, Treat EG, Haft-Candell L, Leppert JT, Harper JD, Said J, Raman S, Smith RB, Belldegrun AS, Schulam PG: Comparison of accuracy of 14-, 18- and 20-G needles in ex-vivo renal mass biopsy: a prospective, blinded study. BJU Int; 2010 Apr;105(7):940-5
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  • [Title] Comparison of accuracy of 14-, 18- and 20-G needles in ex-vivo renal mass biopsy: a prospective, blinded study.
  • OBJECTIVE: To prospectively determine the accuracy of 14-, 18- and 20-G core needle biopsies to render the appropriate histological diagnosis of solid, enhancing renal masses, using a controlled, ex-vivo biopsy technique.
  • RESULTS: The final pathological evaluation classified 21 masses (68%) as clear cell renal cell carcinoma (RCC), three (10%) as papillary RCC, three (10%) as chromophobe RCC, three (10%) as oncocytoma and one (3%) as a benign lymphoid infiltrate.
  • In two cases chromophobe RCC was misdiagnosed with oncocytoma, and vice versa.
  • CONCLUSION: In this study a minimum of an 18-G biopsy needle was the most accurate in determining the histological diagnosis.
  • Clear cell and papillary RCCs were accurately diagnosed on biopsy using an 18-G, whereas oncocytoma and chromophobe RCC were difficult to differentiate using standard H&E techniques and immunohistochemistry.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Biopsy, Needle / standards. Carcinoma, Papillary / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Nephrectomy / methods

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  • (PMID = 19888984.001).
  • [ISSN] 1464-410X
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] England
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24. Muñoz-Delgado E, Montenegro MF, Morote-García JC, Campoy FJ, Cabezas-Herrera J, Kovacs G, Vidal CJ: The expression of cholinesterases in human renal tumours varies according to their histological types. Chem Biol Interact; 2008 Sep 25;175(1-3):340-2
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  • [Title] The expression of cholinesterases in human renal tumours varies according to their histological types.
  • The change in the expression of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities in neoplastic colon and lung prompted us to study the possible effect of cancer on the expression of cholinesterases (ChEs) in kidney.
  • Samples of papillary renal cell carcinoma (pRCC), conventional RCC (cRCC), chromophobe RCC (chRCC) and renal oncocytoma (RON), beside adjacent non-cancerous tissues, were analyzed.
  • Abundant amphiphilic AChE dimers (G(2)(A)) and fewer monomers (G(1)(A)) were identified in healthy kidney as well as in all tumour classes.
  • RT-PCR showed similar amounts of AChE-H, AChE-T and BuChE mRNAs in healthy kidney.
  • The data support the idea that, as in lung tumours, in renal carcinomas expression of ChE mRNAs, biosynthesis of molecular components and level of enzyme activity change according to the specific kind of cell from which tumours arise.
  • [MeSH-major] Acetylcholinesterase / metabolism. Butyrylcholinesterase / metabolism. Kidney Neoplasms / enzymology

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  • (PMID = 18482720.001).
  • [ISSN] 0009-2797
  • [Journal-full-title] Chemico-biological interactions
  • [ISO-abbreviation] Chem. Biol. Interact.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] EC 3.1.1.- / Butyrylcholinesterase; EC 3.1.1.7 / Acetylcholinesterase
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25. Mogorovich A, Giannarini G, De Maria M, Manassero F, Selli C: Multifocal and bilateral renal oncocytoma: a case report and review of the literature. Arch Ital Urol Androl; 2007 Sep;79(3):130-4
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  • [Title] Multifocal and bilateral renal oncocytoma: a case report and review of the literature.
  • A 78-year-old man presenting with synchronous, multifocal and bilateral renal oncocytomas underwent a staged nephron-sparing surgery with removal of six lesions.
  • At 14-month follow-up the renal function was preserved and no recurrent disease was evident.

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  • (PMID = 18041365.001).
  • [ISSN] 1124-3562
  • [Journal-full-title] Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
  • [ISO-abbreviation] Arch Ital Urol Androl
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 42
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26. Mai KT, Teo I, Belanger EC, Robertson SJ, Marginean EC, Islam S: Progesterone receptor reactivity in renal oncocytoma and chromophobe renal cell carcinoma. Histopathology; 2008 Feb;52(3):277-82
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  • [Title] Progesterone receptor reactivity in renal oncocytoma and chromophobe renal cell carcinoma.
  • AIMS: To investigate the reactivity for oestrogen and progesterone receptors (ER and PR) in renal oncocytoma (RO) and chromophobe renal cell carcinoma (CHRCC).
  • MATERIALS AND METHODS: Thirty-eight RO, 25 CHRCC, 20 papillary RCC with oncocytic cytoplasm and 10 clear cell RCC with dominant eosinophilic cytoplasm were submitted for immunohistochemistry for ER, PR, CD117 and RCC.
  • CONCLUSIONS: PR can be used in combination with CD117 and RCC in the differential diagnosis of RO and eosinophilic variant of CHRCC with other RCC with oncocytic or eosinophilic cytoplasm.
  • [MeSH-major] Adenoma, Oxyphilic / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Renal Cell / metabolism. Kidney Neoplasms / metabolism. Receptors, Progesterone / metabolism
  • [MeSH-minor] Cell Nucleus / metabolism. Cell Nucleus / pathology. Diagnosis, Differential. Female. Humans. Immunoenzyme Techniques. Male. Proto-Oncogene Proteins c-kit / metabolism. Receptors, Estrogen / metabolism


27. Ivey BS, Devarajan K, Sundaram CP: Bilateral oncocytoma and the value of needle biopsy. Can J Urol; 2010 Apr;17(2):5131-4
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  • [Title] Bilateral oncocytoma and the value of needle biopsy.
  • INTRODUCTION: Renal oncocytoma represents a diagnostic challenge to urologists.
  • We present three patients with bilateral renal oncocytomas.
  • CASES: All three patients presented with bilateral renal masses and through surgical means, were diagnosed with oncocytoma.
  • Renal biopsies were used to diagnose oncocytoma in the contralateral kidney.
  • DISCUSSION: Considering oncocytoma represents up to 16% of renal masses, there is overtreatment of benign disease due the difficulty in distinguishing between histologies on radiographs.
  • Even when the diagnosis of oncocytoma is made, concurrent renal cell carcinoma can be found in a small subset of patients.
  • The value of renal biopsy in these patients thus becomes increasingly important.
  • Accuracy in establishing a diagnosis is better than 70% in most series.
  • Tissue acquisition remains a barrier to accurate diagnosis.
  • Although not routine, patients with bilateral masses or impaired renal function may be candidates for renal biopsy.
  • CONCLUSIONS: Oncocytoma in the setting of bilateral renal masses presents a difficult clinical scenario.
  • The clinician must exclude renal cell carcinoma from the differential diagnosis.
  • Renal biopsy represents a safe and accurate method towards that end so that patients can be followed radiographically.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Biopsy, Needle / methods. Kidney Neoplasms / pathology

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  • (PMID = 20398456.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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28. Heckmann M, Heinrich M, Humke U, Bautz W, Uder M: [Differential diagnosis of focal lesions of the kidney in CT and MRT]. Rontgenpraxis; 2008;56(6):219-40
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  • [Title] [Differential diagnosis of focal lesions of the kidney in CT and MRT].
  • The great majority of renal masses are found incidentally as a result of the use of ultrasonography, computed tomography (CT) and magnetic resonance imaging (MRI).
  • If ultrasonography is not diagnostic CT or MRI should be initiated to differentiate lesions of the kidney that need surgical intervention from those that do not and from those that need follow-up examinations.
  • Cystic renal masses are characterized by using the Bosniak classification, including category IIF.
  • In solid Lesions of the kidney first non-surgical lesions as well as lymphoma, renal infarction and nephritis should be excluded.
  • Identifying fatty components in renal lesions is very important because in angiomyolipoma they are almost always present.
  • CT and MRI are exellent for tumor detection.
  • Careful evaluation of imaging finding combined with the patient's history should assist the radiologist in making the proper diagnosis or recommending the appropriate treatment in most cases.
  • This article provides a review about renal masses, the imaging methods for their evaluation and their characteristic features at CT and MR imaging.
  • Different lesions are demonstrated like xantogranulomatous pyelonephritis, acute pyelonephritis, renal infarction, lymphoma, angiomyolipoma, renal oncocytoma, cystic lesion and polycystic disease the kidney, echinococcosis, renal cystadenoma, metastases, renal cell carcinoma (RCC), and multiple bilateral RCC in patients with Hippel-Lindau-Syndrome.
  • This article should help to differentiate complex cystic lesions of the kidney by using the Bosniak-classification, especially Bosniak Category IIF.
  • [MeSH-major] Kidney Diseases / diagnosis. Magnetic Resonance Imaging / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Contrast Media. Diagnosis, Differential. Female. Follow-Up Studies. Gadolinium DTPA. Humans. Kidney Diseases, Cystic / classification. Kidney Diseases, Cystic / diagnosis. Kidney Diseases, Cystic / radiography. Kidney Neoplasms / diagnosis. Kidney Neoplasms / radiography. Lymphoma / diagnosis. Lymphoma / radiography. Male. Polycystic Kidney Diseases / diagnosis. Polycystic Kidney Diseases / radiography. Pyelonephritis / diagnosis. Pyelonephritis / radiography. von Hippel-Lindau Disease / diagnosis. von Hippel-Lindau Disease / radiography

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  • (PMID = 19294868.001).
  • [ISSN] 0035-7820
  • [Journal-full-title] Röntgenpraxis; Zeitschrift für radiologische Technik
  • [ISO-abbreviation] Rontgenpraxis
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
  • [Number-of-references] 24
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29. D'Antonio A, Caleo A, Caleo O, Addesso M, Boscaino A: Hepatocellular carcinoma metastatic to the kidney mimicking renal oncocytoma. Hepatobiliary Pancreat Dis Int; 2010 Oct;9(5):550-2
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  • [Title] Hepatocellular carcinoma metastatic to the kidney mimicking renal oncocytoma.
  • BACKGROUND: Renal metastases of hepatocellular carcinoma (HCC) are very rare.
  • METHODS: We describe the clinico-pathological features of a rare case of HCC metastatic to the kidney in which the renal mass was the clinical debut of disease.
  • The patient was a 54-year-old woman previously submitted to orthotopic liver transplantation, who underwent left nephrectomy for a renal mass.
  • RESULTS: Histologically, the tumor was composed mainly of epithelioid cells with homogeneous acidophilic cytoplasm resembling oncocytoma or primary renal carcinoma with oncocytic features.
  • A correct diagnosis was made on the basis of positive immunostaining for hepatocyte paraffin 1.
  • CONCLUSIONS: Metastasis to the kidney is a rare complication that should be considered whenever a renal mass is present in patients with HCC.
  • Since HCC may histologically resemble primary renal tumors such as oncocytoma, pathologists must be aware of this possibility above all in patients referred for liver transplantation and treated with immunosuppressant drugs.
  • Immunohistochemistry is particularly helpful to establish a precise diagnosis in cases of doubt.
  • [MeSH-major] Carcinoma, Hepatocellular / diagnosis. Carcinoma, Hepatocellular / pathology. Kidney Neoplasms / diagnosis. Kidney Neoplasms / secondary. Liver Neoplasms / diagnosis. Liver Neoplasms / pathology
  • [MeSH-minor] Adenoma, Oxyphilic / diagnosis. Diagnosis, Differential. Fatal Outcome. Female. Humans. Liver Transplantation / pathology. Middle Aged. Neoplasm Metastasis

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  • (PMID = 20943467.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] Oncocytoma, renal
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30. Kim SS, Choi YD, Jin XM, Cho YM, Jang JJ, Juhng SW, Choi C: Immunohistochemical stain for cytokeratin 7, S100A1 and claudin 8 is valuable in differential diagnosis of chromophobe renal cell carcinoma from renal oncocytoma. Histopathology; 2009 Apr;54(5):633-5
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  • [Title] Immunohistochemical stain for cytokeratin 7, S100A1 and claudin 8 is valuable in differential diagnosis of chromophobe renal cell carcinoma from renal oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Keratin-7 / metabolism. Kidney Neoplasms / diagnosis. Membrane Proteins / metabolism. S100 Proteins / metabolism
  • [MeSH-minor] Biomarkers, Tumor / analysis. Claudins. Diagnosis, Differential. Humans. Immunohistochemistry / methods. Staining and Labeling / methods


31. Nagashima Y, Mitsuya T, Shioi KI, Noguchi S, Kishida T, Hamano A, Ohgo Y, Tsuura Y, Ogawa T, Aoki I, Yao M: Renal oncocytosis. Pathol Int; 2005 Apr;55(4):210-5
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  • [Title] Renal oncocytosis.
  • Renal oncocytosis is a rare disorder in which numerous oncocytic nodules develop in the kidney.
  • Nineteen years previously she had developed a tumorous lesion in the right kidney, which had been diagnosed as oncocytoma with laparotomic biopsy.
  • Recently the kidney was removed because of enlargement of the tumor.
  • The renal parenchyma was entirely replaced with numerous brownish nodules.
  • Histologically, the nodules were composed of nests of uniform oncocytic cells.
  • Ultrastructurally, the oncocytic cells contained numerous mitochondria.
  • Based on these findings, the lesion was diagnosed as renal oncocytosis.
  • It was not possible to determine whether the larger nodules should be diagnosed as oncocytoma or a part of oncocytosis.
  • Despite the rare occurrence pathologists and urologists should be aware of renal oncocytosis, as a precursor lesion of renal oncocytoma and chromophobe renal cell carcinoma.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Kidney / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Cadherins / analysis. DNA Mutational Analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratin-7. Keratins / analysis. Microscopy, Electron. Middle Aged. Mucin-1 / analysis. Neoplasms, Multiple Primary / pathology. Proteins / genetics. Proto-Oncogene Proteins. Tumor Suppressor Proteins. Vimentin / analysis

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  • (PMID = 15826248.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Cadherins; 0 / FLCN protein, human; 0 / KRT7 protein, human; 0 / Keratin-7; 0 / Mucin-1; 0 / Proteins; 0 / Proto-Oncogene Proteins; 0 / Tumor Suppressor Proteins; 0 / Vimentin; 68238-35-7 / Keratins
  • [Number-of-references] 21
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32. Németh I, Sükösd F, Béli L, Kiss A, Pajor L, Mikó T, Iványi B: [Adult renal neoplasms in the material of the Pathology Department of the Szeged University]. Orv Hetil; 2005 Apr 3;146(14):653-8
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  • [Title] [Adult renal neoplasms in the material of the Pathology Department of the Szeged University].
  • AIMS: The authors investigated the frequencies of the various histological types of adult renal tumours.
  • Among the malignant tumours, the frequency of renal cell carcinomas was 91.1% (n = 371).
  • 88.4% of the renal cell carcinomas (n = 328) were of conventional type, 5.6% (n = 21) were papillary and 4% (n = 15) were chromophobe.
  • As far as benign tumours are concerned (13.2%, n = 62), oncocytomas (n = 37, 7.8% of all the tumours) affected mainly females, whereas angiomyolipomas (n = 21, 4.4% of all the tumours) occurred in females only.
  • In 13 oncocytoma cases, the tumours were initially diagnosed as malignant.
  • CONCLUSIONS: Adult malignant renal tumours affect mainly patients around the age of 60.
  • The commonest diagnosis was clear cell carcinoma of conventional type.
  • In comparison with the literature data, oncocytomas were relatively common (8% instead of 3%), and not rarely, it was difficult to distinguish them from renal cell carcinomas.
  • [MeSH-major] Carcinoma / epidemiology. Carcinoma / pathology. Kidney Neoplasms / epidemiology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Clear Cell / epidemiology. Adenocarcinoma, Clear Cell / pathology. Adenoma, Chromophobe / epidemiology. Adenoma, Chromophobe / pathology. Adenoma, Oxyphilic / epidemiology. Adenoma, Oxyphilic / pathology. Adult. Aged. Angiomyolipoma / epidemiology. Angiomyolipoma / pathology. Carcinoma, Papillary / epidemiology. Carcinoma, Papillary / pathology. Carcinoma, Renal Cell / epidemiology. Carcinoma, Renal Cell / pathology. Carcinoma, Transitional Cell / epidemiology. Carcinoma, Transitional Cell / pathology. Female. Humans. Hungary / epidemiology. Male. Middle Aged. Nephrectomy

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  • (PMID = 15889540.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
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33. Choi YD, Kim KS, Ryu S, Park Y, Cho NH, Rha SH, Jang JJ, Ro JY, Juhng SW, Choi C: Claudin-7 is highly expressed in chromophobe renal cell carcinoma and renal oncocytoma. J Korean Med Sci; 2007 Apr;22(2):305-10
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  • [Title] Claudin-7 is highly expressed in chromophobe renal cell carcinoma and renal oncocytoma.
  • We tested the possibility that expression of claudin-7 could be used as a marker of renal tumors originating from the distal nephron.
  • We examined the immunohistochemical expression of claudin-7 and parvalbumin in 239 renal tumors, including 179 clear cell renal cell carcinoma (RCC)s, 29 papillary RCCs, 20 chromophobe RCCs, and 11 renal oncocytomas.
  • Claudin-7 and parvalbumin immunostains were positive in 3.4%, 7.8% of clear cell RCCs, 34.5%, 31.0% of papillary RCCs, 95.0%, 80.0% of chromophobe RCCs, and 72.7%, 81.8% of renal oncocytomas, respectively.
  • The expression pattern of claudin-7 was mostly diffuse in chromophobe RCC and was either focal or diffuse in oncocytoma.
  • Claudin-7 can be used as a useful diagnostic marker in diagnosing chromophobe RCC and oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / metabolism. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / metabolism. Kidney Neoplasms / diagnosis. Kidney Neoplasms / metabolism. Membrane Proteins / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Claudins. Humans. Neoplasm Proteins / metabolism. Nephrons / metabolism. Reproducibility of Results. Sensitivity and Specificity. Tissue Distribution. Tumor Cells, Cultured

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  • (PMID = 17449941.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CLDN7 protein, human; 0 / Claudins; 0 / Membrane Proteins; 0 / Neoplasm Proteins
  • [Other-IDs] NLM/ PMC2693599
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34. Wang HY, Mills SE: KIT and RCC are useful in distinguishing chromophobe renal cell carcinoma from the granular variant of clear cell renal cell carcinoma. Am J Surg Pathol; 2005 May;29(5):640-6
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  • [Title] KIT and RCC are useful in distinguishing chromophobe renal cell carcinoma from the granular variant of clear cell renal cell carcinoma.
  • The distinction between chromophobe renal cell carcinoma, the granular cell variant of clear cell renal cell carcinoma, and renal oncocytoma is a common diagnostic dilemma.
  • The usefulness of KIT, CD10, RCC, and RON in the differential diagnosis of these renal epithelial tumors was investigated.
  • KIT was 100% positive in chromophobe renal cell carcinoma (11 of 11) and renal oncocytoma (12 of 12).
  • The KIT staining pattern was identical in both tumor types, with cytoplasmic membrane attenuation, and fine granular cytoplasmic staining.
  • In contrast, KIT was absent in all granular cell variants of clear cell renal cell carcinoma (0 of 6).
  • RCC was observed in more than 80% of the granular cell variant of clear cell renal cell carcinoma (5 of 6) but was negative in all chromophobe renal cell carcinomas (0 of 11) and renal oncocytomas (0 of 12).
  • CD10 was expressed in 100% of the granular cell variant of clear cell renal cell carcinoma (6 of 6), 72% of chromophobe renal cell carcinomas (8 of 11), and 58% of renal oncocytomas (7 of 12).
  • RON was 100% positive in the chromophobe renal cell carcinomas (11 of 11) and renal oncocytomas (12 of 12) but only 50% positive in the granular cell variant of clear cell renal cell carcinoma (3 of 6).
  • Colloidal iron was diffusely and strongly positive in more than 80% of the chromophobe renal cell carcinomas (9 of 11), focally and weakly positive in 41% of the renal oncocytomas (5 of 12) but negative in all granular cell variant of clear cell renal cell carcinoma (0 of 6).
  • 1) KIT is a very sensitive marker for both chromophobe renal cell carcinoma and renal oncocytoma;.
  • 2) immunohistochemistry using antibodies to KIT combined with RCC was sufficient to discriminate between chromophobe renal cell carcinoma and the granular cell variant of clear cell renal cell carcinoma; and 3) neither RON, nor KIT, nor a combination of this panel can be used to distinguish chromophobe renal cell carcinoma from renal oncocytoma.
  • Colloidal iron staining aided in this distinction for the majority of the chromophobe renal cell carcinomas (more than 80% positive) and renal oncocytomas (close to 60% negative).
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Mitogen-Activated Protein Kinases. Proto-Oncogene Proteins c-kit
  • [MeSH-minor] Antigens, Neoplasm. Biomarkers, Tumor. Cytoplasmic Granules / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Neprilysin. Receptor Protein-Tyrosine Kinases

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  • (PMID = 15832088.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; EC 2.7.1.- / RON protein; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.11.22 / MOK protein, human; EC 2.7.11.24 / Mitogen-Activated Protein Kinases; EC 3.4.24.11 / Neprilysin
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35. DeWitt J, Gress FG, Levy MJ, Hernandez LV, Eloubeidi MA, Mishra G, Sherman S, Al-Haddad MA, LeBlanc JK: EUS-guided FNA aspiration of kidney masses: a multicenter U.S. experience. Gastrointest Endosc; 2009 Sep;70(3):573-8
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  • [Title] EUS-guided FNA aspiration of kidney masses: a multicenter U.S. experience.
  • BACKGROUND: Tissue sampling of renal lesions is traditionally performed with percutaneous US or CT guidance.
  • To date, only 3 known cases of EUS-guided FNA (EUS-FNA) of a renal mass have been reported.
  • OBJECTIVE: To describe a multicenter experience with the indications, yield, and complications from attempted EUS-FNA of a kidney mass.
  • PATIENTS: Consecutive subjects undergoing attempted EUS-FNA of a kidney mass.
  • Endosonographers at 15 other teaching hospitals were contacted regarding EUS findings and follow-up of any EUS-guided renal biopsies previously attempted or considered at that institution.
  • INTERVENTIONS: EUS-FNA of a kidney mass.
  • MAIN OUTCOME MEASUREMENTS: Biopsy indications, yield, diagnosis, and complications.
  • Kidney masses (median diameter 32 mm; range 11-60 mm) were located in the upper (n = 12) and lower (n = 3) poles of the left (n = 10) and right (n = 5) kidneys, respectively.
  • Results of EUS-FNA (median 3 passes; range 2-4 passes) in 13 (87%) procedures were diagnostic of (n = 7) or highly suspicious for (n = 1) renal cell carcinoma (RCC), atypical cells (n = 2), oncocytoma (n = 1), benign cyst (n = 1), and nondiagnostic (n = 1).
  • Surgical resection confirmed RCC in 7 patients in whom preoperative EUS-FNA demonstrated RCC (n = 5) or oncocytoma (n = 1) or was not performed (n = 1).
  • CONCLUSIONS: EUS-FNA of renal masses is rarely performed at the U.S. teaching hospitals surveyed.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Endosonography / methods. Kidney Neoplasms / pathology. Kidney Neoplasms / ultrasonography
  • [MeSH-minor] Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / ultrasonography. Aged. Aged, 80 and over. Carcinoma, Renal Cell / pathology. Carcinoma, Renal Cell / ultrasonography. Cohort Studies. Confidence Intervals. Female. Follow-Up Studies. Hospitals, Teaching. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Probability. Retrospective Studies. Risk Assessment. Sensitivity and Specificity. United States

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  • (PMID = 19560139.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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36. Picken MM, Chyna B, Flanigan RC, Lee JM: Analysis of chromosome 1p abnormalities in renal oncocytomas by loss of heterozygosity studies: correlation with conventional cytogenetics and fluorescence in situ hybridization. Am J Clin Pathol; 2008 Mar;129(3):377-82
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  • [Title] Analysis of chromosome 1p abnormalities in renal oncocytomas by loss of heterozygosity studies: correlation with conventional cytogenetics and fluorescence in situ hybridization.
  • We previously showed by cytogenetics and fluorescence in situ hybridization (FISH) that the most common chromosomal abnormality in renal oncocytomas is loss of chromosome 1 or 1p.
  • LOH was detected in at least 1 locus in 12 (86%) of 14 renal oncocytomas studied, with other loci being noninformative or not interpretable (1 case).
  • These results provide further evidence to support widespread abnormalities in chromosome 1p in renal oncocytoma.
  • Determining whether such abnormalities are unique to renal oncocytomas or are also present in other tumors requires further studies.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Chromosomes, Human, Pair 1 / genetics. Kidney Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chromosome Aberrations. DNA, Neoplasm / analysis. Female. Humans. In Situ Hybridization, Fluorescence. Loss of Heterozygosity. Male. Microsatellite Repeats. Middle Aged. Polymerase Chain Reaction

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  • (PMID = 18285259.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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37. Hes O, Michal M, Síma R, Vanecek T, Brunelli M, Martignoni G, Kuroda N, Alvarado Cabrero I, Perez-Montiel D, Hora M, Urge T, Dvorák M, Jarosová M, Yang X: Renal oncocytoma with and without intravascular extension into the branches of renal vein have the same morphological, immunohistochemical, and genetic features. Virchows Arch; 2008 Feb;452(2):193-200
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  • [Title] Renal oncocytoma with and without intravascular extension into the branches of renal vein have the same morphological, immunohistochemical, and genetic features.
  • We attempted to investigate the clinicopathological correlation of renal oncocytoma (RO) with renal vein extension.
  • We identified seven ROs with extension into the branches of renal vein.
  • Renal vein extension was grossly suspected in five of seven cases and histologically confirmed in all seven cases.
  • Tumor cells were positive for cytokeratins, mitochondrial-antigen (MIA), epithelial membrane antigen (EMA), and parvalbumin; five of seven tumors were focally positive for CD117.
  • (1) renal oncocytomas may have intravascular extension to the branches of the renal vein;.
  • (2) renal oncocytomas with intravascular extension to the branches of the renal vein have the same morphological, immunohistochemical, and cytogenetic findings as have their counterparts without evidence of intravascular invasion;.
  • (3) the absence of metastases suggests an overall benign behavior of this tumor, but this has to be substantiated by further studies with a long-term follow-up; and (4) in a renal tumor with granular cytoplasm showing renal vein extension, it is necessary to carefully exclude renal cell carcinomas such as chromophobe RCC, oncocytic variant of papillary RCC, and granular variant of clear cell RCC.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Kidney Neoplasms / pathology. Renal Veins / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Chromosome Aberrations. Cytoplasm / ultrastructure. DNA, Neoplasm / analysis. Female. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Mitochondria / ultrastructure. Neoplasm Invasiveness. Nephrectomy


38. Kubacka M, Pośpiech L, Jaworska M, Markowska-Woyciechowska A: [A case of bilateral oncocytomas of the submandibular gland and synchronous renal oncocytomas]. Otolaryngol Pol; 2005;59(6):903-5
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  • [Title] [A case of bilateral oncocytomas of the submandibular gland and synchronous renal oncocytomas].
  • A case of 42 years-old man with bilateral big sized (12 x 5 cm and 10 x 4,5 cm) oncocytoma in submandibular glands was presented.
  • Oncocytoma is a rare benign neoplasm observed in numerous of organs.
  • In the case described besides submandibular glands tumours, accessory oncocytic tumours in both kidneys were diagnosed.
  • The comparison of the both tumours histology allowed to establish proper diagnosis.
  • The case is presented because of the explicitly of the oncocytoma location especially in the both submandibular glands simultaneously with tumour of the same histology in distant organs.
  • [MeSH-major] Adenoma, Oxyphilic / complications. Kidney Neoplasms / complications. Neoplasms, Multiple Primary. Submandibular Gland Neoplasms / complications
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male

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  • (PMID = 16521462.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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39. Yamashita R, Nakamura M, Matsuzaki M, Matsui T, Yamaguchi R, Niwakawa M, Tobisu K, Asakura K, Ito I: [Clinical factors associated with benign renal tumors]. Nihon Hinyokika Gakkai Zasshi; 2009 Nov;100(7):679-85
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  • [Title] [Clinical factors associated with benign renal tumors].
  • OBJECTIVES: In this study, we sought to define the incidence of benign renal tumors in our institute and to clarify the clinical factors associated with benign renal tumors, in order to assist in forming preoperative differential diagnoses.
  • METHODS: From October 2002 to July 2007, we performed 157 nephrectomies in patients preoperatively diagnosed with renal cell carcinoma.
  • We also compared clinical factors, including age, sex and tumor size, between the benign and malignant renal tumors.
  • RESULTS: The patient's median age was 67 years (mean age, 63 years), and the median tumor diameter was 3.0 cm (mean, 3.2 cm).
  • Benign renal tumors were found in 10 (12%) of the 81 tumors; these included seven cases of oncocytoma and three cases of angiomyolipoma with minimal fat.
  • Several factors were significant clinical determinants of differentiation between benign and malignant renal tumors: homogeneity in CT, female gender, and small tumor size all predominated in cases of benign tumors.
  • CONCLUSIONS: When a patient, especially a female, presents with a small and homogeneous renal tumor, careful consideration should be given to the possibility of a benign process, which needs further consideration before performing excessive surgery.
  • [MeSH-major] Adenoma, Oxyphilic. Angiomyolipoma. Kidney Neoplasms
  • [MeSH-minor] Age Factors. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies. Sex Factors. Tomography, Spiral Computed

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  • (PMID = 19999132.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Japan
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40. Yang XJ, Sugimura J, Schafernak KT, Tretiakova MS, Han M, Vogelzang NJ, Furge K, Teh BT: Classification of renal neoplasms based on molecular signatures. J Urol; 2006 Jun;175(6):2302-6
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  • [Title] Classification of renal neoplasms based on molecular signatures.
  • PURPOSE: Gene expression microarray studies have demonstrated distinct molecular signatures for different types of renal neoplasms based on overall gene expression patterns.
  • However, in most of these studies the investigators used renal tumors with defined histology.
  • We analyzed a test set of renal tumors in double-blind fashion using recently established molecular profiles of renal tumors as benchmarks.
  • Analysis was clustered with our previously established molecular profiles of 91 histologically defined kidney neoplasms and comparative genomic microarray analysis while blinded to tumor histology and clinical information.
  • RESULTS: With molecular analysis 9, 4, 2 and 1 tumors were classified as clear cell, papillary RCC, chromophobe RCC, and renal oncocytoma, respectively.
  • One of the 2 tumors with a discrepancy between molecular and pathological diagnoses was composed of oncocytoma and high grade clear cell RCC, and the other was chromophobe RCC that histologically mimicked papillary RCC.
  • CONCLUSIONS: We report the feasibility of the molecular diagnosis and classification of unknown renal neoplasms.
  • Molecular diagnosis appears to be reliable and comparable to the standard of urological pathology.
  • This molecular method may be a potentially useful test for establishing an accurate diagnosis that can impact clinical management.
  • [MeSH-major] Carcinoma, Renal Cell / classification. Carcinoma, Renal Cell / genetics. Kidney Neoplasms / classification. Kidney Neoplasms / genetics. Oligonucleotide Array Sequence Analysis

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  • (PMID = 16697863.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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41. Descotes JL, Doublet JD: [Renal imaging and biopsy for diagnosis of renal masses]. Ann Urol (Paris); 2006 Nov;40 Suppl 3:S86-90
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  • [Title] [Renal imaging and biopsy for diagnosis of renal masses].
  • [Transliterated title] Apport de l'imagerie et des biopsies dans le diagnostic des masses solides du rein.
  • Incidental diagnosis of renal tumors is more and more common.
  • Ultrasound allows the diagnosis of solid tumors, thereby excluding cysts.
  • Renal cancer is the main etiology, but benign tumors can be suspected in small tumors less than 4 cm.
  • Angiomyolipoma and oncocytoma are the more frequent benign tumors.
  • Angiolipoma can be diagnosed with CT-scan, but there are no radiological criteria for the diagnosis of oncocytoma.
  • Renal percutaneous biopsy can be helpful in selected cases.
  • It is recommended for bilateral tumors, or when a renal metastasis is suspected.
  • For small lesions with radiological features consistent with the diagnosis of benign tumor, renal biopsy can confirm this diagnosis and lead surgical abstention.
  • Nevertheless, few centers have a regular practise of renal biopsy.
  • [MeSH-major] Kidney Neoplasms / diagnosis

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  • (PMID = 17366862.001).
  • [ISSN] 0003-4401
  • [Journal-full-title] Annales d'urologie
  • [ISO-abbreviation] Ann Urol (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 23
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42. Delongchamps NB, Vieillefond A, Peyromaure M, Saighi D, Conquy S, Debré B, Zerbib M: [Hybrid renal tumors: a report of two patients]. Prog Urol; 2010 Dec;20(13):1223-6
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  • [Title] [Hybrid renal tumors: a report of two patients].
  • [Transliterated title] Tumeurs rénales hybrides: à propos de deux patients.
  • PURPOSE: Renal hybrid tumors (HT) are characterized by the association of both oncocytes- and chromophobe-cells within the same tumor.
  • RESULTS: Two patients were diagnosed with multiple but small tumors of the kidney, and were treated with partial nephrectomy.
  • Pathological analysis of these tumors showed oncocytoma-like and chromophobe-like cells intermixed in the same stroma.
  • CONCLUSIONS: HT may constitute a spectrum of tumors between renal oncocytoma and chromophobe renal cell carcinoma.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Angiomyolipoma / pathology. Kidney Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 21130404.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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43. Esposito M, Varca V, Simonato A, Toncini C, Carmignani G, Derchi L: [Coexistence of different histotypes of renal carcinoma:our experience and literature review]. Urologia; 2009 Apr-Jun;76(2):130-2
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  • [Title] [Coexistence of different histotypes of renal carcinoma:our experience and literature review].
  • The coexistence of multiple, synchronous primary tumors of different histology within the same kidney is a rare condition.
  • We report herein a series of five patients with two tumors of different histology involving synchronously the same kidney.
  • We reviewed the pathology reports of a series of 381 patients who underwent surgery for primary renal tumors at our institution from 2000 to 2007.
  • RESULTS. Five out of 381 patients (1.37%) had coexistence of two primary tumors of different histology within the same kidney.
  • CONCLUSIONS. The coexistence of multiple and synchronous primary tumors of different histology within the same kidney has been only rarely described.
  • To the best of our knowledge, in literature there are only case reports with the exception of a case of renal oncocytoma with evolving papillary RCC.

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  • (PMID = 21086315.001).
  • [ISSN] 1724-6075
  • [Journal-full-title] Urologia
  • [ISO-abbreviation] Urologia
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] United States
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44. Sydor A, Sulowicz W, Stompór T, Plezia B, Wrona A, Okon K: Two consecutive cases of renal oncocytomatosis in a single-center experience. Clin Nephrol; 2009 Apr;71(4):433-40
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  • [Title] Two consecutive cases of renal oncocytomatosis in a single-center experience.
  • Renal oncocytoma is a rare finding and represents the small percentage of all kidney tumors.
  • This kind of tumor is benign and diagnosed accidentally (on autopsy or during nephrectomy performed for other reasons).
  • On rare occasions, truly multiple tumors are seen, affecting the entire renal parenchyma; this condition is called oncocytosis or oncocytomatosis.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Kidney Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Comorbidity. Diagnosis, Differential. Fatal Outcome. Female. Humans. Male

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  • (PMID = 19356377.001).
  • [ISSN] 0301-0430
  • [Journal-full-title] Clinical nephrology
  • [ISO-abbreviation] Clin. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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45. Rosenkrantz AB, Hindman N, Fitzgerald EF, Niver BE, Melamed J, Babb JS: MRI features of renal oncocytoma and chromophobe renal cell carcinoma. AJR Am J Roentgenol; 2010 Dec;195(6):W421-7
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  • [Title] MRI features of renal oncocytoma and chromophobe renal cell carcinoma.
  • OBJECTIVE: The purpose of this study was to retrospectively describe the MRI features of the pathologically related entities renal oncocytoma and chromophobe renal cell carcinoma (RCC).
  • MATERIALS AND METHODS: Twenty-eight cases of histologically proven renal oncocytoma and 15 of chromophobe RCC evaluated with preoperative MRI from January 2003 through June 2009 at our institution were independently reviewed for an array of MRI features by two radiologists blinded to the final histopathologic diagnosis.
  • These features were tabulated and compared between chromophobe RCC and renal oncocytoma by use of the Mann-Whitney test and binary logistic regression.
  • RESULTS: Renal oncocytoma and chromophobe RCC showed no significant difference in size or any of 16 qualitative imaging features (p = 0.0842-1.0, reader 1; p = 0.0611-1.0, reader 2).
  • Microscopic fat, hemorrhage, cysts, infiltrative margins, perinephric fat invasion, renal vein invasion, enhancement homogeneity, and hypervascularity were each observed in less than 20% of cases by both readers.
  • A central scar and segmental enhancement inversion (a recently described finding in which early contrast-enhanced images show relatively more enhanced and less enhanced intralesional components with inversion of their relative enhancement on later images) were observed by both readers in at least 10% of cases of both renal oncocytoma and of chromophobe RCC with no significant difference between the two entities (p = 0.2092-0.2960).
  • CONCLUSION: We have presented the largest series to date of the MRI features of both renal oncocytoma and chromophobe RCC.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Magnetic Resonance Imaging / methods


46. Yen TH, Chen Y, Lin JL, Ng KF: Renal oncocytoma in Taiwan. Ren Fail; 2006;28(2):141-7
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  • [Title] Renal oncocytoma in Taiwan.
  • BACKGROUND: Renal oncocytoma has been repeatedly reported in Western countries, but only a few cases have been reported in Eastern countries.
  • This study aims to review the clinical course of renal oncocytoma in an Eastern country such as Taiwan.
  • MATERIALS AND METHODS: Sixteen cases of renal oncocytoma seen between 1987 and 2002 at Chang Gung Memorial Hospital, Taipei, Taiwan, were studied.
  • RESULTS: Preoperatively, all patients were diagnosed to have renal cell carcinoma, following various radiologic studies.
  • Perioperatively, frozen sections of three patients indicated renal oncocytoma in two and renal cell carcinoma in one.
  • Renal oncocytoma has marked similarities to renal cell carcinoma, according to various radiologic, cytologic, and pathological investigations, so an accurate diagnosis is difficult to achieve, either preoperatively or perioperatively.
  • Notably, all patients survived with no evidence of tumor recurrence.
  • CONCLUSIONS: The experience in Taiwan is generally that renal oncocytoma behaves benignly, as reported in other areas.
  • The excellent prognosis associated with this tumor appears to indicate that partial nephrectomy may suffice for removing the tumor, while sparing other unaffected renal parenchyma.
  • [MeSH-major] Adenoma, Oxyphilic. Kidney Neoplasms
  • [MeSH-minor] Aged. Carcinoma, Renal Cell / diagnosis. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Nephrectomy. Taiwan

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  • (PMID = 16538972.001).
  • [ISSN] 0886-022X
  • [Journal-full-title] Renal failure
  • [ISO-abbreviation] Ren Fail
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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47. Shomori K, Nagashima Y, Kuroda N, Honjo A, Tsukamoto Y, Tokuyasu N, Maeta N, Matsuura K, Hijiya N, Yano S, Yokoyama S, Ito H, Moriyama M: ARPP protein is selectively expressed in renal oncocytoma, but rarely in renal cell carcinomas. Mod Pathol; 2007 Feb;20(2):199-207
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  • [Title] ARPP protein is selectively expressed in renal oncocytoma, but rarely in renal cell carcinomas.
  • In the present study, we generated the anti-ARPP monoclonal antibody, YAS11, immunoreactive with the N-terminal region (amino-acids residues 1-145) of the ARPP protein.
  • Further, we immunohistochemically analyzed 100 renal tumors including 14 oncocytomas, and 86 renal cell carcinomas (RCCs).
  • Interestingly, ARPP was not detected in any of 11 chromophobe RCCs, suggesting that ARPP may be useful for differential diagnosis between oncocytoma and chromophobe RCC.
  • Furthermore, we found that ARPP was selectively expressed in part of the distal renal tubule in normal kidney.
  • Immunoelectron microscopy with anti-ARPP antibody revealed that ARPP was localized in mitochondria and nuclei in both the normal distal renal tubule and oncocytoma, suggesting that oncocytoma may be derived from the distal nephron, and probably from part of the distal renal tubule.
  • [MeSH-major] Adenoma, Oxyphilic / metabolism. Carcinoma, Renal Cell / metabolism. Kidney Neoplasms / metabolism. Muscle Proteins / metabolism. Nuclear Proteins / metabolism. Repressor Proteins / metabolism
  • [MeSH-minor] Antibodies, Monoclonal / biosynthesis. Antibodies, Monoclonal / immunology. Biomarkers, Tumor / metabolism. Blotting, Western. Cell Nucleus / metabolism. Cell Nucleus / ultrastructure. Diagnosis, Differential. Fluorescent Antibody Technique, Indirect. HeLa Cells. Humans. Immunoenzyme Techniques. Kidney Tubules, Distal / metabolism. Kidney Tubules, Distal / ultrastructure. Microscopy, Immunoelectron. Mitochondria / metabolism. Mitochondria / ultrastructure. Transfection

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  • (PMID = 17206105.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ANKRD2 protein, human; 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / Muscle Proteins; 0 / Nuclear Proteins; 0 / Repressor Proteins
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48. Morelli L, Pusiol T, Piscioli I, Larosa M, Pozzoli GL, Monica B: Concurrent occurrence of three primary neoplasms with different hystotype in the same kidney, associated with an adenoma of the omolateral adrenal gland: first case report. Int J Urol; 2006 Sep;13(9):1236-9
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  • [Title] Concurrent occurrence of three primary neoplasms with different hystotype in the same kidney, associated with an adenoma of the omolateral adrenal gland: first case report.
  • We present an unusual case of concurrent occurrence of three synchronous primary tumors in the same kidney (oncocytoma, chromophobe renal cell carcinoma, angiomyolipoma) associated to an adenoma of the omolateral adrenal gland in a patient with no evident clinical symptoms.
  • The immunohistochemistry showed a positivity for KIT in oncocytoma and chromophobe cell carcinoma, and a weak positivity in the angiomyolipoma, only in the cells positive for HMB-45.
  • [MeSH-major] Adenoma / pathology. Adenoma, Oxyphilic / pathology. Adrenal Gland Neoplasms / pathology. Angiomyolipoma / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 16984560.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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49. Sukov WR, Ketterling RP, Lager DJ, Carlson AW, Sinnwell JP, Chow GK, Jenkins RB, Cheville JC: CCND1 rearrangements and cyclin D1 overexpression in renal oncocytomas: frequency, clinicopathologic features, and utility in differentiation from chromophobe renal cell carcinoma. Hum Pathol; 2009 Sep;40(9):1296-303
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  • [Title] CCND1 rearrangements and cyclin D1 overexpression in renal oncocytomas: frequency, clinicopathologic features, and utility in differentiation from chromophobe renal cell carcinoma.
  • SUMMARY: Renal oncocytoma is a benign tumor occurring singly or as multiple synchronous lesions.
  • The histologic features of renal oncocytoma may overlap with those of chromophobe renal cell carcinoma.
  • Chromosomal translocations involving the CCND1 locus at 11q13 and overexpression of cyclin D1 occur in a subset of renal oncocytomas.
  • We evaluated a series of 63 renal oncocytomas and 36 chromophobe renal cell carcinomas and assessed the clinical features, cyclin D1 overexpression by immunohistochemistry, and alterations of the CCND1 gene by fluorescence in situ hybridization.
  • All 36 chromophobe renal cell carcinomas were negative for cyclin D1 overexpression and alterations of CCND1.
  • Of the 63 renal oncocytomas, 21 (33%) showed cyclin D1 overexpression.
  • Of 21 renal oncocytomas with cyclin D1 overexpression, a CCND1 rearrangement was detected in 12 (57%).
  • A CCND1 rearrangement was also identified in 1 (2%) of the 42 renal oncocytomas without cyclin D1 overexpression.
  • Of 42 renal oncocytomas without cyclin D1 overexpression, 16 (38%) were from patients with multiple renal oncocytomas at nephrectomy.
  • Of 21 renal oncocytomas with cyclin D1 overexpression, only 1 (5%) patient had multiple renal oncocytomas (P = .006).
  • Of the 25 patients whose original tumor showed no cyclin D1 overexpression, 8 (32%) developed a subsequent renal oncocytoma.
  • None of 15 patients whose original tumor showed cyclin D1 overexpression had a subsequent renal oncocytoma (P = .016).
  • The findings of this study suggest that renal oncocytomas lacking cyclin D1 overexpression may be associated with the development of multiple renal oncocytomas and that these patients are more likely to develop subsequent renal oncocytomas suggesting the need for more frequent clinical for these patients and little need for follow-up in patients with renal oncocytomas overexpressing cyclin D1.
  • The data also show that cyclin D1 overexpression and CCND1 rearrangements by fluorescence in situ hybridization are absent in chromophobe renal cell carcinoma, suggesting that these are useful when differentiating between renal oncocytoma and chromophobe renal cell carcinoma.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Carcinoma, Renal Cell / genetics. Cyclin D1 / genetics. Gene Rearrangement. Kidney Neoplasms / genetics
  • [MeSH-minor] Case-Control Studies. Chromosomes, Human, Pair 11 / metabolism. Cytogenetic Analysis / methods. Diagnosis, Differential. Female. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Karyotyping. Male. Nephrectomy. Translocation, Genetic. Tumor Cells, Cultured


50. Sibony M, Vieillefond A: [Non clear cell renal cell carcinoma. 2008 update in renal tumor pathology]. Ann Pathol; 2008 Oct;28(5):381-401
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  • [Title] [Non clear cell renal cell carcinoma. 2008 update in renal tumor pathology].
  • Non clear cell renal cell carcinomas represent almost 20% of all renal neoplasms.
  • Since molecular techniques are expensive, diagnosis still relies on morphological and immuno-histochemical criteria detailed hereby.
  • Papillary renal cell carcinomas are the most important group and its classification is more and more complex.
  • It encompasses low-grade papillary carcinomas (type 1 papillary renal cell carcinoma, oncocytic papillary renal cell carcinoma) and high-grade papillary carcinomas (type 2 papillary renal cell carcinoma, juvenile papillary carcinoma corresponding to renal carcinoma associated with Xp11.2 translocations and unclassified carcinomas).
  • The so-called carcinoma of collecting ducts of Bellini and renal medullary carcinoma should be considered as intrarenal urothelial carcinoma or as high-grade papillary or unclassified carcinoma.
  • Sarcomatoid carcinoma derives from morphological progression of any type of renal cell carcinoma.
  • The group of oncocytomas/chromophobe renal cell carcinomas can be considered as a spectrum from benign (oncocytoma) to malignant neoplasm (chromophobe renal cell carcinoma).
  • Angiomyolipoma is usually a benign mesenchymatous neoplasm, that can be sporadic or familial (tuberous sclerosis).
  • Renal epithelial and stromal tumors (REST) is a new concept gathering two benign mixed mesenchymal and epithelial tumors: cystic nephroma and mixed epithelial and stromal tumors (MEST).
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adenoma, Oxyphilic / classification. Adenoma, Oxyphilic / genetics. Adenoma, Oxyphilic / pathology. Carcinoma / classification. Carcinoma / genetics. Carcinoma / pathology. Chromosome Mapping. Chromosomes, Human. Humans. Immunohistochemistry. Kidney / pathology. Kidney Tubules, Collecting / pathology. Necrosis


51. Trpkov K, Yilmaz A, Uzer D, Dishongh KM, Quick CM, Bismar TA, Gokden N: Renal oncocytoma revisited: a clinicopathological study of 109 cases with emphasis on problematic diagnostic features. Histopathology; 2010 Dec;57(6):893-906
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  • [Title] Renal oncocytoma revisited: a clinicopathological study of 109 cases with emphasis on problematic diagnostic features.
  • AIM: To evaluate problematic diagnostic features in renal oncocytoma.
  • METHODS AND RESULTS: One hundred and nine cases of oncocytoma were reviewed and the problematic gross and microscopic features recorded.
  • Limited foci with chromophobe-like histology (not exceeding 5% of the neoplasm) were found in 13 (11.9%) oncocytomas.
  • After a median follow-up of 52 months (range 1-113 months), there was no disease recurrence, progression or death attributed to oncocytoma.
  • CONCLUSIONS: The recognition of the spectrum of morphological changes observed in renal oncocytoma should help pathologists establish a diagnosis of oncocytoma in problematic cases.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Kidney / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Renal Cell / metabolism. Carcinoma, Renal Cell / pathology. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Necrosis. Retrospective Studies

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  • [Copyright] © 2010 Blackwell Publishing Limited.
  • (PMID = 21166703.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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52. Neuzillet Y, Lechevallier E, André M, Daniel L, Nahon O, Coulange C: [Outcome of oncocytomas diagnosed by percutaneous renal biopsy]. Prog Urol; 2006 Sep;16(4):435-8
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  • [Title] [Outcome of oncocytomas diagnosed by percutaneous renal biopsy].
  • OBJECTIVE: Renal oncocytoma is a benign tumour that is usually diagnosed postoperatively.
  • We studied the outcome of patients with renal oncocytoma diagnosed by percutaneous biopsy and not operated.
  • MATERIAL: From January 1998 to April 2004, on a series of 148 renal tumour biopsies performed in our centre, 15 showed oncocytoma.
  • RESULTS: The mean age of these patients at diagnosis was 57.6 +/- 14.4 years and the mean tumour diameter was 3.49 +/- 2.43 cm with a mean volume of 62.3 +/- 135.4 cm3.
  • Operated patients were younger (45.5 +/- 11.1 years vs 65.6 +/- 10.3 years) and had larger tumours at diagnosis (50 +/- 30.1 mm vs 27.3 +/- 10.5 mm).
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Kidney Neoplasms / pathology

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  • (PMID = 17069035.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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53. Plaut MA, El Mahou S, Popa L, Cantagrel A, Mazières B, Laroche M: Systemic vasculitis revealing a benign tumor: a paraneoplastic syndrome? Joint Bone Spine; 2006 Jul;73(4):462-4
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  • [Title] Systemic vasculitis revealing a benign tumor: a paraneoplastic syndrome?
  • Systemic vasculitis is a rare event in the course of malignant tumors and has not been described in association with benign tumors.
  • We report a case of renal oncocytoma in a patient who presented with digital necrosis, arthralgia, myalgia, and a decline in general health.
  • The symptoms resolved fully after tumor excision, supporting a diagnosis of paraneoplastic syndrome.
  • [MeSH-major] Adenoma, Oxyphilic / complications. Kidney Neoplasms / complications. Paraneoplastic Syndromes / complications. Vasculitis / etiology
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged

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  • (PMID = 16807043.001).
  • [ISSN] 1297-319X
  • [Journal-full-title] Joint, bone, spine : revue du rhumatisme
  • [ISO-abbreviation] Joint Bone Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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54. Muscarella LA, Barbano R, Augello B, Formica V, Micale L, Zelante L, D'Agruma L, Merla G: An 11-bp duplication in the promoter region of the VHL gene in a patient with cerebellar hemangioblastoma and renal oncocytoma. J Hum Genet; 2007;52(6):485-91
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  • [Title] An 11-bp duplication in the promoter region of the VHL gene in a patient with cerebellar hemangioblastoma and renal oncocytoma.
  • Central nervous system hemangioblastomas are benign vascular tumours that may present sporadically or as manifestation of the von Hippel-Lindau (VHL) disease.
  • VHL Syndrome is a rare autosomal dominant disorder characterized, besides hemangioblastomas, by susceptibility to multifocal and bilateral renal cell carcinoma and cysts, retinal angiomas, pheochromocytoma, epididymis cystoadenoma, pancreatic cysts and/or islet cell tumours.
  • Germline mutations of VHL tumour suppressor gene cause the VHL disease, while somatic mutations have been associated with sporadic hemangioblastomas and clear-cell renal carcinomas.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Cerebellar Neoplasms / genetics. Hemangioblastoma / genetics. Kidney Neoplasms / genetics. Promoter Regions, Genetic. Von Hippel-Lindau Tumor Suppressor Protein / genetics. von Hippel-Lindau Disease / genetics


55. Zbar B, Glenn G, Merino M, Middelton L, Peterson J, Toro J, Coleman J, Pinto P, Schmidt LS, Choyke P, Linehan WM: Familial renal carcinoma: clinical evaluation, clinical subtypes and risk of renal carcinoma development. J Urol; 2007 Feb;177(2):461-5; discussion 465
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  • [Title] Familial renal carcinoma: clinical evaluation, clinical subtypes and risk of renal carcinoma development.
  • PURPOSE: Familial renal carcinoma is defined as families with 2 or more individuals with renal cell carcinoma without evidence of known hereditary renal carcinoma syndromes.
  • To better characterize this familial cancer we reviewed renal carcinoma families evaluated at the National Cancer Institute between 1990 and 2004 to identify distinctive features of these families.
  • We also determined the risk of renal carcinoma in first-degree relatives of affected family members.
  • MATERIALS AND METHODS: We evaluated 141 at risk asymptomatic relatives of affected individuals from 50 families with 2 or more members with renal carcinoma.
  • Histology slides of renal tumors from affected family members were reviewed.
  • At risk members from renal carcinoma families were screened for occult renal neoplasms by renal ultrasound and computerized tomography.
  • DNA from select families was tested for germline mutations of known renal carcinoma genes when clinically indicated and constitutional cytogenetic analysis was performed to search for germline chromosome alterations.
  • RESULTS: Familial renal carcinoma families could be subdivided into subtypes based on tumor multiplicity and renal tumor histology.
  • Of 141 at risk members of renal carcinoma families screened for occult renal tumors 2 were found to have occult renal tumors, which were identified as renal oncocytoma and a solid tumor that was not resected, respectively.
  • No histologically confirmed occult renal carcinomas were detected in at risk family members.
  • Several families previously classified as having familial renal carcinoma were found on further evaluation to have hereditary renal cancer syndromes.
  • CONCLUSIONS: Familial renal carcinoma is a heterogeneous clinical and pathological entity.
  • Familial renal carcinoma was subdivided into groups based on tumor multiplicity and tumor pathology.
  • The empirical risk of histologically documented renal carcinoma in first-degree relatives who were members of familial renal carcinoma families was less than 1:141.
  • One renal oncocytoma and 1 small solid renal tumor were detected.
  • [MeSH-major] Carcinoma, Renal Cell / genetics. Kidney Neoplasms / genetics

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  • (PMID = 17222609.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CO / N01-CO-12400; United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] United States
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56. Jeon HG, Lee SR, Kim KH, Oh YT, Cho NH, Rha KH, Yang SC, Han WK: Benign lesions after partial nephrectomy for presumed renal cell carcinoma in masses 4 cm or less: prevalence and predictors in Korean patients. Urology; 2010 Sep;76(3):574-9
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  • [Title] Benign lesions after partial nephrectomy for presumed renal cell carcinoma in masses 4 cm or less: prevalence and predictors in Korean patients.
  • OBJECTIVES: To investigate the prevalence and predictors associated with benign lesions in Korean patients after partial nephrectomy for presumed renal cell carcinoma (RCC) for lesions measuring ≤ 4 cm.
  • METHODS: We retrospectively investigated the medical records of 376 patients who underwent partial nephrectomy for presumed RCC with renal masses of size ≤ 4 cm between June 1997 and December 2008.
  • Demographic and clinicopathologic parameters were compared between benign lesions and RCC.
  • Logistic regression was done to identify parameters associated with benign lesions.
  • RESULTS: In the 376 patients, 81 tumors (21.5%) were benign, including 35 angiomyolipomas (9.3%), 26 complicated cysts (6.9%), 11 oncocytomas (2.9%), and 9 others (2.4%).
  • Univariate analysis showed that time of surgery, female sex, younger age, and normal body mass index (body mass index (BMI) < 23 kg/m(2)) were associated with benign pathologic findings.
  • On multiple logistic regression analysis, female sex (OR, 4.91; 95% CI, 2.76-08.75; P < .001), age (OR, 0.97; 95% CI, 0.95-0.99; P = .009), and time of surgery (OR, 0.33; 95% CI, 0.11-0.95; P = .040) were independent predictors of benign histologic features.
  • Tumor size, incidental diagnosis, and BMI were not significant predictors (P > .05).
  • CONCLUSIONS: Our study with a large cohort of Asian patients showed that the prevalence of benign lesions was similar to previously reported Western studies.
  • However, the most common benign lesion was angiomyolipoma, compared with oncocytoma in Western countries.
  • The results of this study may help clinicians counsel female and younger patients recently diagnosed with small renal masses and decide the most appropriate treatment, including renal biopsies and close observation.
  • [MeSH-major] Carcinoma, Renal Cell / epidemiology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / epidemiology. Kidney Neoplasms / pathology. Nephrectomy


57. Perepletchikov AM, Alroy J, Ucci A: Diagnostic utility of CD10, CD3 and electron microscopy of renal cortical neoplasms with oncocytic features. Pathol Res Pract; 2010 Jun 15;206(6):384-6
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  • [Title] Diagnostic utility of CD10, CD3 and electron microscopy of renal cortical neoplasms with oncocytic features.
  • No currently defined imaging techniques can reliably distinguish between oncocytoma and epithelial malignant lesions with oncocytic features in the kidney; therefore, patients must undergo resection or, in certain circumstances, biopsy to definitively establish diagnosis.
  • Immunohistochemical staining for CD10 and CD3, evaluation of the staining pattern and intensity, and relevant morphologic appearance are helpful diagnostic tools in discriminating between renal cell carcinoma with oncocytic features and renal oncocytoma.
  • Accurate determination of the tumor origin would allow for the use of limited nephron sparing and laparoscopic surgical approaches to treat appropriately.
  • [MeSH-major] Antigens, CD3 / biosynthesis. Carcinoma, Renal Cell / ultrastructure. Kidney Neoplasms / ultrastructure. Neprilysin / biosynthesis
  • [MeSH-minor] Adenoma, Oxyphilic. Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission

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  • [Copyright] Published by Elsevier GmbH.
  • (PMID = 19942355.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD3; 0 / Biomarkers, Tumor; EC 3.4.24.11 / Neprilysin
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58. Yen TH, Chen Y, Fu JF, Weng CH, Tian YC, Hung CC, Lin JL, Yang CW: Proliferation of myofibroblasts in the stroma of renal oncocytoma. Cell Prolif; 2010 Jun;43(3):287-96
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  • [Title] Proliferation of myofibroblasts in the stroma of renal oncocytoma.
  • OBJECTIVES: Myofibroblasts are a vital component of stroma of many malignant neoplasms, but it is not yet established whether stromal myofibroblasts also exist in benign tumours such as oncocytoma of the kidney.
  • MATERIALS AND METHODS: Histomorphological and immunohistochemical analysis of 16 renal oncocytomas diagnosed at Chang Gung Memorial Hospital, Taiwan, has been performed.
  • RESULTS: Renal oncocytomas were composed of oncocytes, large cells with granular eosinophilic cytoplasm, arranged mostly in sheets, in tubulocystic or combined pattern.
  • Wnt/beta-catenin signalling was not implicated in this neoplasm, as there was no loss of E-cadherin membranous localization or expression of intranuclear beta-catenin in the cells.
  • CONCLUSIONS: Renal oncocytomas were composed of two independent compartments: benign oncocytes and pronounced fibrotic stroma, which consisted of proliferating myofibroblasts (SMA- and MIB-1-positive) which were associated with excessive deposition of extracellular matrix (periodic acid Schiff-component, collagen I-, collagen III- and fibronectin-positive, and desmin- and human caldesmon-negative).
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Fibroblasts / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Cell Proliferation. Extracellular Matrix / metabolism. Extracellular Matrix / pathology. Extracellular Matrix Proteins / metabolism. Female. Humans. Male. Middle Aged. Myoblasts / metabolism. Myoblasts / pathology. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / physiopathology. Stromal Cells / metabolism. Stromal Cells / pathology

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  • (PMID = 20412129.001).
  • [ISSN] 1365-2184
  • [Journal-full-title] Cell proliferation
  • [ISO-abbreviation] Cell Prolif.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Extracellular Matrix Proteins
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59. Choudhary S, Rajesh A, Mayer NJ, Mulcahy KA, Haroon A: Renal oncocytoma: CT features cannot reliably distinguish oncocytoma from other renal neoplasms. Clin Radiol; 2009 May;64(5):517-22
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  • [Title] Renal oncocytoma: CT features cannot reliably distinguish oncocytoma from other renal neoplasms.
  • AIM: To retrospectively review the computed tomography (CT) imaging features of a series of histologically confirmed renal oncocytomas and to determine whether imaging features are predictive of this subtype of benign renal epithelial tumour.
  • MATERIALS AND METHODS: From May 2001 to October 2007, 21 patients with 28 renal masses, confirmed as renal oncocytoma on histological examination of the resection specimen, were identified from the pathology database at our institution.
  • The preoperative imaging findings were retrospectively analysed to determine characteristic features, if any, to predict this rare subtype of benign renal tumour.
  • In 18 (64.3%) lesions the enhancement of the tumour was isodense to renal cortex.
  • Ten (35.7%) lesions were hypodense to renal cortex.
  • CONCLUSION: Renal oncocytoma is typically described as being hypervascular and homogeneous, with a characteristic central stellate scar on CT.
  • Therefore, imaging characteristics alone are unreliable when differentiating between oncocytoma and renal cell carcinoma, and histopathological diagnosis remains the reference standard.
  • [MeSH-major] Adenoma, Oxyphilic / radiography. Kidney Neoplasms / radiography
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Renal Cell / diagnosis. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies. Tomography, Spiral Computed / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 19348848.001).
  • [ISSN] 1365-229X
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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60. Mete O, Kilicaslan I, Gulluoglu MG, Uysal V: Can renal oncocytoma be differentiated from its renal mimics? The utility of anti-mitochondrial, caveolin 1, CD63 and cytokeratin 14 antibodies in the differential diagnosis. Virchows Arch; 2005 Dec;447(6):938-46
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  • [Title] Can renal oncocytoma be differentiated from its renal mimics? The utility of anti-mitochondrial, caveolin 1, CD63 and cytokeratin 14 antibodies in the differential diagnosis.
  • Among the epithelial renal tumours with eosinophilic cytoplasm, the main differential diagnostic problem arises between renal oncocytomas (ROs) and eosinophilic variants of chromophobe renal cell carcinomas (RCCs).
  • We investigated the possible role of anti-mitochondrial (AMA), anti-caveolin 1 (CAV1), anti-CD63 (CD63) and anti-cytokeratin 14 (CK14) antibodies in the differential diagnosis of eosinophilic epithelial tumours and applied the Muller and Mowry modification of Hale's colloidal iron stain (HCI).
  • We showed CK14 antibody not to be useful in the differential diagnosis of the eosinophilic epithelial renal tumours.
  • [MeSH-major] Adenoma, Oxyphilic / metabolism. Adenoma, Oxyphilic / pathology. Biomarkers, Tumor / analysis. Kidney Neoplasms / metabolism. Kidney Neoplasms / pathology
  • [MeSH-minor] Antigens, CD / metabolism. Antigens, CD63. Carcinoma, Renal Cell / metabolism. Carcinoma, Renal Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratins / metabolism. Male. Middle Aged. Mitochondria / immunology. Platelet Membrane Glycoproteins / metabolism. Sensitivity and Specificity

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  • (PMID = 16133362.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD63; 0 / Biomarkers, Tumor; 0 / CD63 protein, human; 0 / Platelet Membrane Glycoproteins; 68238-35-7 / Keratins
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61. Zubakov D, Stupar Z, Kovacs G: Differential expression of a new isoform of DLG2 in renal oncocytoma. BMC Cancer; 2006;6:106
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  • [Title] Differential expression of a new isoform of DLG2 in renal oncocytoma.
  • BACKGROUND: Renal oncocytoma, a benign tumour of the kidney, may pose a differential diagnostic problem due to overlapping phenotype with chromophobe renal cell carcinoma or other types of renal cell tumours.
  • METHODS: In the current study we applied various techniques, including Affymetrix microarray hybridization and semiquantitative RT-PCR, to identify genes expressed differentially in renal oncocytomas.
  • Subsequently, we used RACE and Northern blot hybridization to characterize the potential candidates for molecular diagnosis.
  • The new isoform is specifically upregulated in renal oncocytoma, whereas the known DLG2 gene is downregulated in this type of kidney tumour.
  • CONCLUSION: The new isoform of DLG2 is the promising candidate gene for molecular differential diagnostics of renal oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / genetics. Guanylate Kinase / genetics. Kidney Neoplasms / diagnosis. Kidney Neoplasms / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / genetics. Diagnosis, Differential. Down-Regulation. Genetic Markers. Humans. Nucleic Acid Amplification Techniques. Oligonucleotide Array Sequence Analysis. Protein Isoforms. Reverse Transcriptase Polymerase Chain Reaction. Up-Regulation

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  • (PMID = 16640776.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Genetic Markers; 0 / Protein Isoforms; 0 / Tumor Suppressor Proteins; EC 2.7.4.8 / DLG2 protein, human; EC 2.7.4.8 / Guanylate Kinase
  • [Other-IDs] NLM/ PMC1524971
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62. Brunelli M, Delahunt B, Gobbo S, Tardanico R, Eccher A, Bersani S, Cossu-Rocca P, Parolini C, Balzarini P, Menestrina F, Cheng L, Eble JN, Martignoni G: Diagnostic usefulness of fluorescent cytogenetics in differentiating chromophobe renal cell carcinoma from renal oncocytoma: a validation study combining metaphase and interphase analyses. Am J Clin Pathol; 2010 Jan;133(1):116-26
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  • [Title] Diagnostic usefulness of fluorescent cytogenetics in differentiating chromophobe renal cell carcinoma from renal oncocytoma: a validation study combining metaphase and interphase analyses.
  • We investigated the usefulness of interphase fluorescence in situ hybridization (FISH) analysis to differentiate between 11 chromophobe renal carcinomas and 12 renal oncocytomas, showing different clinical outcomes, when compared with conventional metaphase cytogenetics by karyotyping.
  • Karyotypically, 3 chromophobe renal cell carcinomas showed losses of chromosomes, 3 were polyploid, 1 was normal, and 4 failed to grow.
  • FISH on chromophobe renal cell carcinomas showed a high percentage of cases (10/11 [91%]) with multiple numeric losses among chromosomes 1, 2, 6, 10, and 17; this interphase pattern was observed irrespective of the 3 different metaphase karyotypes.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Chromosome Aberrations. In Situ Hybridization, Fluorescence. Kidney Neoplasms / diagnosis
  • [MeSH-minor] DNA, Neoplasm / analysis. Diagnosis, Differential. Humans. Interphase / genetics. Metaphase / genetics. Tissue Array Analysis


63. Han XN, Peng LR, Liu GH, Wang J: [Multiphasic spiral CT scanning features in 100 patients with small renal cell carcinoma]. Zhonghua Zhong Liu Za Zhi; 2007 May;29(5):382-5
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  • [Title] [Multiphasic spiral CT scanning features in 100 patients with small renal cell carcinoma].
  • OBJECTIVE: To investigate the role of multiphasic spiral computed tomography (SCT) in the differential diagnosis of small renal cell carcinoma.
  • METHODS: The data of 100 patients with small renal cell carcinoma (< or = 3.0 cm) proved by pathology were retrospectively reviewed in order to analyze the features of SCT during plain, corticomedullary and excretory phases.
  • RESULTS: There were 38 tumor masses in the left kidney and 62 in the right one.
  • According to the 2004 WHO histological classification criteria for the tumors of the kidney.
  • Seventy-six patients had clear cell renal cell carcinoma, 4 multilocular clear cell renal cell carcinomas, 9 papillary renal cell carcinoma, 4 chromophobe renal cell carcinomas and 7 unclassified renal cell carcinomas.
  • Clear cell renal cell carcinoma exhibited rich blood supply and inhomogeneous density due to hemorrhage, necrosis or cystic degeneration.
  • Multilocular clear cell renal cell carcinoma presented as a multilocular cystic mass with thin wall and septa, instead of an expansile nodule.
  • Papillary renal cell carcinoma showed inhomogeneous density and hypovascular distribution.
  • Chromophobe renal cell carcinoma was relatively homogeneous and hypovascular.
  • Compared with clear cell renal cell carcinoma, unclassified renal cell carcinoma showed inhomogeneous density and hypervascular distribution with more invading growth features than the other subtypes.
  • CONCLUSION: Commonly encountered subtypes of the small renal cell carcinoma exhibit their own specific features in multiphasic spiral CT, which may be helpful in differential diagnosis, but each subtype should be differentiated from the renal oncocytoma, cystic nephroma, complex renal cyst, renal angiomyolipoma with minimal fat and renal infiltrating urothelial carcinoma.
  • [MeSH-major] Carcinoma, Renal Cell / radiography. Kidney Neoplasms / radiography. Tomography, Spiral Computed / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Papillary / radiography. Child. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Prognosis. Retrospective Studies

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  • (PMID = 17892138.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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64. Jayaratna I, Munver R, Disick G, Han MW, Sawczuk I: Paraneoplastic hypertension associated with renal oncocytoma: management with cryoablation. Urology; 2009 Jan;73(1):209.e9-11
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  • [Title] Paraneoplastic hypertension associated with renal oncocytoma: management with cryoablation.
  • Paraneoplastic hypertension associated with a renal oncocytoma is an unreported syndrome.
  • We report a unique case of a patient with multidrug-resistant hypertension who was found to have a solitary renal mass.
  • Histologic review of intraoperative biopsy specimens revealed findings consistent with renal oncocytoma.
  • To our knowledge, this is the first report of hypertension in the setting of a renal oncocytoma, with subsequent improvement of this paraneoplastic syndrome after cryoablation.
  • [MeSH-major] Adenoma, Oxyphilic / complications. Adenoma, Oxyphilic / surgery. Cryosurgery. Hypertension / etiology. Hypertension / surgery. Kidney Neoplasms / complications. Kidney Neoplasms / surgery. Paraneoplastic Syndromes / etiology. Paraneoplastic Syndromes / surgery


65. Okoń K, Sińczak-Kuta A: Nuclear morphometry as a tool of limited capacity for distinguishing renal oncocytoma from chromophobe carcinoma. Pol J Pathol; 2008;59(1):9-13
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  • [Title] Nuclear morphometry as a tool of limited capacity for distinguishing renal oncocytoma from chromophobe carcinoma.
  • The principal types of renal tumors include malignant clear cell renal cell carcinoma, chromophobe carcinoma (ChRCC), papillary carcinoma and benign oncocytoma (RO) and adenoma.
  • Both oncocytoma and chromophobe carcinoma are characterized by a solid growth pattern of cell with abundant cytoplasm and in some cases may be difficult to distinguish based on histology only.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Cell Nucleus / pathology. Kidney Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Image Processing, Computer-Assisted. Male. Middle Aged

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  • (PMID = 18655365.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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66. Scialpi M, Cardone G, Barberini F, Piscioli I, Rotondo A: Renal oncocytoma: misleading diagnosis of benignancy by using angular interface sign at MR imaging. Radiology; 2010 Nov;257(2):587-8; author reply 588
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  • [Title] Renal oncocytoma: misleading diagnosis of benignancy by using angular interface sign at MR imaging.
  • [MeSH-major] Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Contrast Media. Diagnosis, Differential. Gadolinium DTPA. Humans. Kidney Diseases / diagnosis. Kidney Diseases / pathology. Predictive Value of Tests

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  • [CommentOn] Radiology. 2010 May;255(2):501-7 [20160001.001]
  • (PMID = 20959552.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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67. Deshpande A, Munshi M: Renal oncocytoma with hyaline globules: cytologic diagnosis by guided fine needle aspiration, a case report. Indian J Pathol Microbiol; 2005 Apr;48(2):230-5
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  • [Title] Renal oncocytoma with hyaline globules: cytologic diagnosis by guided fine needle aspiration, a case report.
  • Renal oncocytomas are rare renal parenchymal neoplasms which have a good prognosis.
  • An accurate pre-operative diagnosis by guided fine needle aspiration cytology helps to plan a more conservative surgery.
  • Cytologic findings in a case of renal oncocytoma are presented.
  • The resected specimen showed the characteristic findings of oncocytoma.
  • Renal oncocytoma has to be distinguished from granular renal cell carcinoma (RCC) and chromophobe cell carcinoma, because of the markedly different prognosis.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / pathology. Kidney Neoplasms / diagnosis. Kidney Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy, Needle. Diagnosis, Differential. Female. Humans

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  • (PMID = 16758678.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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68. Sundararajan S, Dyer J, Pemberton R, Cohen RJ: Asymptomatic giant renal oncocytoma presenting with hypertension. Pathology; 2008 Dec;40(7):723-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Asymptomatic giant renal oncocytoma presenting with hypertension.
  • [MeSH-major] Adenoma, Oxyphilic / complications. Adenoma, Oxyphilic / pathology. Hypertension / etiology. Kidney Neoplasms / complications. Kidney Neoplasms / pathology
  • [MeSH-minor] Adult. Carcinoma, Renal Cell / pathology. Diagnosis, Differential. Humans. Male. Tomography, X-Ray Computed


69. Yamaguchi T, Kuroda N, Imamura Y, Hes O, Michal M, Sima R, Nakayama K, Sato N: Imprint cytologic features of chromophobe renal cell carcinoma morphologically resembling renal oncocytoma: is this an oncocytic variant of chromophobe renal cell carcinoma? Diagn Cytopathol; 2010 Jul;38(7):509-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imprint cytologic features of chromophobe renal cell carcinoma morphologically resembling renal oncocytoma: is this an oncocytic variant of chromophobe renal cell carcinoma?
  • In this article, we report a case of 76-year-old woman with a rare variant of chromophobe renal cell carcinoma (CRCC).
  • Cytologically, renal tumor cells obtained from imprint cytology were isolated or arranged in small or monotonous population cells with abundant granular cytoplasm.
  • Immunocytochemically, the cytoplasm of almost all tumor cells was diffusely positive for vimentin and CK 7.
  • Additionally, tumor cells showed infiltration into some small renal veins covered by a single layer of endothelial cells.
  • These cytological and histological features entirely resembled those of renal oncocytoma.
  • As a result, we confirmed monosomy of chromosomes 7, 10, 13, and 17, and these findings corresponded to the diagnosis of CRCC.
  • Finally, we present a case of renal tumor morphologically resembling renal oncocytoma but genetically showing CRCC.
  • We suggest that oncocytic variant of CRCC may actually exist.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Renal Cell / pathology. Cytological Techniques / methods. Kidney / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Aged. Chromosomes, Human / genetics. Female. Humans. In Situ Hybridization, Fluorescence. Loss of Heterozygosity / genetics. Mutation / genetics. Von Hippel-Lindau Tumor Suppressor Protein / genetics


70. Leroy X, Aubert S, Lemaitre L, Haffner J, Biserte J, Gosselin B: Multilocular cystic renal oncocytoma. J Clin Pathol; 2006 Feb;59(2):223-4
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  • [Title] Multilocular cystic renal oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Kidney Neoplasms / diagnosis

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  • [Cites] AJR Am J Roentgenol. 2003 Mar;180(3):755-8 [12591691.001]
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  • (PMID = 16443744.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1860320
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71. Demirović A, Cesarec S, Spajić B, Tomas D, Bulimbasić S, Milosević M, Marusić Z, Kruslin B: Can renal oncocytoma be distinguished from chromophobe renal cell carcinoma by the presence of fibrous capsule? Virchows Arch; 2010 Jan;456(1):85-9
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  • [Title] Can renal oncocytoma be distinguished from chromophobe renal cell carcinoma by the presence of fibrous capsule?
  • The most important differential diagnosis of chromophobe renal cell carcinoma (CRCC) is renal oncocytoma.
  • Due to overlapping morphological characteristics of renal oncocytoma and CRCC, particularly its eosinophilic variant, making a correct diagnosis can be challenging.
  • To date, no data are available on the presence of the tumor fibrous capsule as a diagnostic feature in differentiating these tumors.
  • The main purpose of this study was to establish the presence and compare the thickness of the tumor fibrous capsule between two tumor groups.
  • A total of 37 tumors--18 cases of CRCC (three eosinophilic and 15 classic) and 19 cases of renal oncocytoma--were analyzed.
  • Four slides of each tumor stained with hematoxylin and eosin were first scanned at low-power magnification (x40) to assess the presence of the capsule.
  • The capsule was present in 12 (66.7%) cases of CRCCs and in only two (10.5%) cases of renal oncocytomas.
  • Statistical analysis showed significant difference between the presence of fibrous capsule in these two observed tumor groups (P = 0.001).
  • Average thickness of capsule in CRCCs was 337.7 microm, and 115.4 microm in renal oncocytomas, but the median was not statistically significant (P = 0.198).
  • Studies with a larger number of cases are needed to conclude if this characteristic could be a low-cost, reliable microscopic feature in differentiating between CRCC and renal oncocytoma.
  • [MeSH-major] Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / diagnosis. Kidney Neoplasms / pathology. Neoplasms, Glandular and Epithelial / diagnosis. Neoplasms, Glandular and Epithelial / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies


72. Krüger S, Sotlar K, Kausch I, Horny HP: Expression of KIT (CD117) in renal cell carcinoma and renal oncocytoma. Oncology; 2005;68(2-3):269-75
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of KIT (CD117) in renal cell carcinoma and renal oncocytoma.
  • Our aim was to analyze KIT expression immunohistochemically in renal cell carcinomas (RCCs) and in oncocytomas.
  • METHODS: Routinely processed, paraffin-embedded specimens from 61 RCCs and 13 renal oncocytomas were investigated immunohistochemically.
  • Cytoplasmic and membrane-bound KIT staining of tumor cells was determined semiquantitatively.
  • Within the group of chromophobe RCCs, negative cytoplasmatic KIT reactivity was significantly correlated with advanced tumor stage (pT > or = 2; p = 0.036).
  • CONCLUSIONS: KIT expression is a hallmark of oncocytoma and chromophobe RCC.
  • [MeSH-major] Adenoma, Oxyphilic / chemistry. Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / chemistry. Kidney Neoplasms / chemistry. Proto-Oncogene Proteins c-kit / analysis
  • [MeSH-minor] Aged. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Neoplasm Staging

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  • [Copyright] Copyright (c) 2005 S. Karger AG, Basel.
  • (PMID = 16015044.001).
  • [ISSN] 0030-2414
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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73. Schmidt LS, Nickerson ML, Warren MB, Glenn GM, Toro JR, Merino MJ, Turner ML, Choyke PL, Sharma N, Peterson J, Morrison P, Maher ER, Walther MM, Zbar B, Linehan WM: Germline BHD-mutation spectrum and phenotype analysis of a large cohort of families with Birt-Hogg-Dubé syndrome. Am J Hum Genet; 2005 Jun;76(6):1023-33
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  • Birt-Hogg-Dubé syndrome (BHD), a genodermatosis characterized by multiple hamartomas of the hair follicle (fibrofolliculoma), predisposes individuals to an increased risk of developing renal neoplasms and spontaneous pneumothorax.
  • Among patients with a mutation in the exon 11 hotspot, significantly fewer renal tumors were observed in patients with the C-deletion than those with the C-insertion mutation.
  • Of the 53 families with BHD whose members inherited either a germline mutation or the affected haplotype, 24 (45%) had at least one member with renal neoplasms.
  • Three families classified with familial renal oncocytoma were identified with BHD mutations, which represents the first disease gene associated with this rare form of renal neoplasm.

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  • (PMID = 15852235.001).
  • [ISSN] 0002-9297
  • [Journal-full-title] American journal of human genetics
  • [ISO-abbreviation] Am. J. Hum. Genet.
  • [Language] ENG
  • [Databank-accession-numbers] OMIM/ 135150
  • [Grant] United States / PHS HHS / / N01-C0-12400
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / FLCN protein, human; 0 / Proteins; 0 / Proto-Oncogene Proteins; 0 / Tumor Suppressor Proteins
  • [Other-IDs] NLM/ PMC1196440
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74. Blanco L, Larrinaga G, Pérez I, López JI, Gil J, Agirregoitia E, Varona A: Acid, basic, and neutral peptidases present different profiles in chromophobe renal cell carcinoma and in oncocytoma. Am J Physiol Renal Physiol; 2008 Apr;294(4):F850-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acid, basic, and neutral peptidases present different profiles in chromophobe renal cell carcinoma and in oncocytoma.
  • Renal cell carcinomas (RCCs) are neoplasias with high prevalence and mortality.
  • We previously reported that several peptidases may be involved in the pathophysiology of clear cell renal cell carcinoma (CCRCC).
  • Now, to gain insight into the reasons that lead the various RCC types to behave very differently with regard to aggressiveness and response to anticancer treatments, we analyzed subsets of chromophobe renal cell carcinoma (ChRCC), and renal oncocytoma (RO), a benign tumor; as well as different grades and stages of CCRCCs.
  • Particulate APN, APB, and APA activities were decreased in both ChRCC and RO (tumor vs. nontumor tissues).
  • Interestingly, activities were downregulated in a tumor-type specific way and the intensities of the decreases were stronger in the benign tumor than in the malignant type.
  • Moreover, when two key histopathological parameters for tumor prognosis (high vs. low stage and grade) were analyzed, increases of activity were also observed in several of these cell surface peptidases (APN, APB).
  • These results may suggest an involvement of several peptidases in the pathophysiology of renal cancer, since they presented different patterns of activity and expression in tumors with different behaviors.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Carcinoma, Renal Cell / genetics. Kidney Neoplasms / genetics. Peptide Hydrolases / genetics
  • [MeSH-minor] Aged. Aged, 80 and over. DNA Primers. Female. Gene Expression Profiling. Humans. Hydrogen-Ion Concentration. Kinetics. Male. Middle Aged. Neoplasm Staging. Polymerase Chain Reaction


75. Rowsell C, Fleshner N, Marrano P, Squire J, Evans A: Papillary renal cell carcinoma within a renal oncocytoma: case report of an incidental finding of a tumour within a tumour. J Clin Pathol; 2007 Apr;60(4):426-8
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  • [Title] Papillary renal cell carcinoma within a renal oncocytoma: case report of an incidental finding of a tumour within a tumour.
  • The most common renal tumours are clear cell, papillary, chromophobe and collecting duct renal cell carcinomas (RCCs), and benign oncocytomas and angiomyolipomas.
  • Tumours with hybrid features between some of these entities have been recognised; in particular, tumours with features of both chromophobe RCC and oncocytoma.
  • Case reports describing one distinct type of primary renal tumour actually within another are very rare.
  • The incidental finding of a papillary RCC located in an oncocytoma in a nephrectomy specimen from a 75-year-old man is described.
  • The cells in the papillary tumour contained three copies, whereas the oncocytoma cells contained only two per nucleus.
  • To our knowledge, this is the first report of a papillary RCC being identified within an oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Mixed Tumor, Malignant / pathology


76. Huang W, Kanehira K, Drew S, Pier T: Oncocytoma can be differentiated from its renal cell carcinoma mimics by a panel of markers: an automated tissue microarray study. Appl Immunohistochem Mol Morphol; 2009 Jan;17(1):12-7
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  • [Title] Oncocytoma can be differentiated from its renal cell carcinoma mimics by a panel of markers: an automated tissue microarray study.
  • BACKGROUND: Differentiating oncocytoma from its renal cell carcinoma (RCC) mimics, particularly chromophobe RCC, can be difficult, especially when limited tissue is available for evaluation.
  • This study presents a panel of markers that are readily available, easy to use, and useful for differential diagnoses of renal tumors.
  • DESIGN: A renal cell neoplasm tissue microarray was constructed including oncocytoma (n=30), chromophobe RCC (n=18), conventional RCC (n=64), papillary RCC (n=50), and benign renal tissues (n=31).
  • CK7, CD10, epithelial membrane antigen, renal cell carcinoma marker (RCCma), vimentin, and endogenous avidin-binding activity (EABA) were studied.
  • RESULT: EABA was positive in 97% of oncocytoma, 26% of conventional RCC and 35% of papillary RCC with granular/eosinophilic (G/E) features and 6% of chromophobe RCC.
  • Vimentin and RCCma were positive in most RCC with G/E features (conventional, 78% and 71%; and papillary, 85% and 76%, respectively), and negative in oncocytoma.
  • CK7 was positive in up to 81% of papillary RCC and 63% of chromophobe RCC, and essentially negative in conventional RCC and oncocytoma.
  • CONCLUSIONS: EABA is an excellent marker for oncocytoma, which can be useful in differentiating oncocytoma from chromophobe RCC.
  • A panel of EABA, vimentin, and RCCma markers can be useful in discerning oncocytoma from RCC with G/E features.

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  • (PMID = 18769342.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Vimentin; EC 2.7.11.22 / MOK protein, human; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
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77. Al-Saleem T, Balsara BR, Liu Z, Feder M, Testa JR, Wu H, Greenberg RE: Renal oncocytoma with loss of chromosomes Y and 1 evolving to papillary carcinoma in connection with gain of chromosome 7. Coincidence or progression? Cancer Genet Cytogenet; 2005 Nov;163(1):81-5
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  • [Title] Renal oncocytoma with loss of chromosomes Y and 1 evolving to papillary carcinoma in connection with gain of chromosome 7. Coincidence or progression?
  • Hybrid tumors of the kidney are not rare.
  • Previous studies of hybrid renal tumors have been valuable for the understanding of the pathogenesis and progression pathways of renal cell neoplasm.
  • In this paper we describe the morphologic, immunohistochemical, and genetic features of 2 oncocytomas with evolving papillary renal cell carcinoma (PRCC) in a nephrectomy specimen of a 60-year old male.
  • The patient was referred for urologic oncology consultation after the incidental discovery of a renal tumor.
  • Papillary carcinoma nests were highlighted with cytokeratin 7 and vimentin positivity and were more prominent in the larger tumor.
  • We postulate that the PRCC represents a neoplastic progression by the gain of chromosome 7 oncocytoma with -Y and -1.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Carcinoma, Papillary / genetics. Chromosome Aberrations. Chromosome Deletion. Chromosomes, Human, Pair 7. Chromosomes, Human, Y. Kidney Neoplasms / genetics

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  • (PMID = 16271962.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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78. Hes O, Michal M: Images in pathology. "Digital'' lung metastasis of a renal oncocytoma. Int J Surg Pathol; 2005 Jul;13(3):280
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Images in pathology. "Digital'' lung metastasis of a renal oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / secondary. Artifacts. Kidney Neoplasms / pathology. Lung / pathology. Lung Neoplasms / secondary. Photomicrography / methods

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  • [CommentIn] Int J Surg Pathol. 2006 Jan;14(1):107 [16501847.001]
  • (PMID = 16086085.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Sokolova IA, Hes O, Michal M, Matsko DE: [Small-cell variant of renal oncocytoma]. Arkh Patol; 2007 Sep-Oct;69(5):34-6
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  • [Title] [Small-cell variant of renal oncocytoma].
  • Renal oncocytoma is a distinct benign tumor accounting for approximately 3-5% of all renal tumors.
  • This neoplasm is easily recognizable in its classic form: there are polygonal cells with abundant granular eosinophilic cytoplasm filled with mitochondria.
  • The tumor cells are arranged in nests and tubular pattern.
  • Here, 1 case of renal oncocytoma with a domination of small cells is reported (the so-called "oncoblasts") arising in elderly woman.
  • The term "small-cell variant of renal oncocytoma" was proposed for these cases.
  • The unusual extensive small-cell component of the tumor may represent a potential diagnostic pitfall for primary or metastatic malignant small cell tumors.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Small Cell / pathology. Cytoplasm / pathology. Kidney Neoplasms / pathology. Mitochondria / pathology
  • [MeSH-minor] Aged. Female. Humans. Neoplasm Metastasis

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  • (PMID = 18074818.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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80. Roy C, Gengler L, Sauer B, Lang H: [Role of contrast enhanced US in the evaluation of renal tumors]. J Radiol; 2008 Nov;89(11 Pt 1):1735-44
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  • [Title] [Role of contrast enhanced US in the evaluation of renal tumors].
  • [Transliterated title] Rôle de l'échographie de contraste dans l'évaluation des tumeurs rénales.
  • PURPOSE: To evaluate the role of contrast enhanced US in the characterization of renal tumors.
  • Eighty-six renal tumors (33 solid, 53 cystic) underwent contrast enhanced US after indeterminate CT/MRI (67 lesions) or US (19 lesions).
  • Diagnosis was achieved in 21 cases.
  • Lesions included: 19 renal cell carcinomas (4 conventional, 14 papillary, 1 tubulocystic), 5 oncocytomas, 3 metastases, 6 pseudomasses, and 53 cystic lesions including 6 malignant tumors.
  • Characterization of solid tumors was possible with specificity of 92.9% for papillary carcinoma, 57.1% for clear cell carcinoma, and 100% for oncocytoma.
  • The specificity for distinguishing solid benign from solid malignant tumor was 100% based on the presence of hypoechogenicity relative to normal renal parenchyma on delayed imaging.
  • CONCLUSION: Contrast enhanced US is easily performed in clinical practice and allows improved characterization of some renal tumors compared to other cross sectional imaging techniques.
  • [MeSH-major] Contrast Media. Kidney Neoplasms / ultrasonography

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  • (PMID = 19106830.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Multicenter Study
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Contrast Media
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81. Ibarz Servio L, Ruiz Domínguez J, Cannata Ortiz P, Olazábal Zudaire A: [Giant renal oncocytoma]. Med Clin (Barc); 2009 Apr 11;132(13):527
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  • [Title] [Giant renal oncocytoma].
  • [Transliterated title] Oncocitoma renal gigante.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Kidney Neoplasms / pathology

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  • (PMID = 19232648.001).
  • [ISSN] 0025-7753
  • [Journal-full-title] Medicina clínica
  • [ISO-abbreviation] Med Clin (Barc)
  • [Language] spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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82. Neuzillet Y, Lechevallier E: [Renal oncocytoma]. Prog Urol; 2006 Apr;16(2):105-11
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  • [Title] [Renal oncocytoma].
  • Due to its nonspecific clinical and radiological features, renal oncocytoma is usually diagnosed on the operative specimen.
  • Histological confirmation of the diagnosis is based on the distinction between oncocytoma and renal cell carcinoma (RCC), which can be difficult.
  • Description of cases in which RCC and oncocytoma are present in the same tumour and the hypothesis of a link between oncocytoma and RCC further complicate the diagnosis of this tumour by the urologist.
  • The authors reviewed the management of tumours suspected to be oncocytoma based on a review of the international literature concerning the diagnosis, natural history and treatment of renal oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic. Kidney Neoplasms

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  • (PMID = 16734229.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 88
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83. Lebret T, Poulain JE, Molinie V, Herve JM, Denoux Y, Guth A, Scherrer A, Botto H: Percutaneous core biopsy for renal masses: indications, accuracy and results. J Urol; 2007 Oct;178(4 Pt 1):1184-8; discussion 1188
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  • [Title] Percutaneous core biopsy for renal masses: indications, accuracy and results.
  • PURPOSE: We evaluated the results, accuracy and clinical incidence of our standard procedure of percutaneous biopsy for solid renal masses.
  • MATERIALS AND METHODS: From March 1999 to April 2005, 119 percutaneous core biopsies of renal masses were performed.
  • Biopsies were proposed when there was no formal evidence for a carcinoma diagnosis on computerized tomography.
  • RESULTS: Benign lesions were diagnosed in 24 biopsies (20.1%), including oncocytoma in 13, angiomyolipoma in 5 and chronic pyelonephritis in 5.
  • Malignancy was identified in 70 biopsies (58.8%), including 57 renal carcinomas (conventional renal cell in 41, papillary in 12 and chromophobe in 4), 4 transitional cell carcinomas, 8 metastases and 1 lymphoma.
  • For 25 biopsies (21%) no accurate diagnosis was possible, including 12 that showed inflammatory tissue and 13 with normal or necrotic tissue.
  • A total of 64 nephrectomies were performed with a biopsy accuracy for histopathological tumor type and Fuhrman nuclear grade of 86% and 46%, respectively.
  • A period of watchful waiting was proposed for 31 patients (34.2%) and no renal malignancies were found.
  • Computerized tomography showed stabilization or disappearance of the initial renal mass.
  • CONCLUSIONS: Percutaneous renal tumor biopsies are safe, cost-effective and often conclusive for an acute histological diagnosis.
  • This procedure could be decisive for choosing the optimal treatment, particularly to avoid nephrectomy for benign lesions.
  • [MeSH-major] Biopsy. Carcinoma, Renal Cell / pathology. Kidney / pathology. Kidney Neoplasms / pathology. Nephrostomy, Percutaneous
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Kidney Diseases / pathology. Kidney Diseases / radiography. Kidney Diseases / surgery. Male. Middle Aged. Neoplasm Staging. Predictive Value of Tests. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 17698122.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Hes O, Michal M, Síma R, Vanecek T, Brunelli M, Martignoni G, Kuroda N, Cabrero IA, Perez-Montiel D, Hora M, Urge T, Dvorák M, Jarosová M, Yang X: Renal oncocytoma with and without intravascular extension into the branches of renal vein have the same morphological, immunohistochemical and genetic features. Virchows Arch; 2008 Mar;452(3):285-93
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  • [Title] Renal oncocytoma with and without intravascular extension into the branches of renal vein have the same morphological, immunohistochemical and genetic features.
  • We attempted to investigate the clinicopathological correlation of renal oncocytoma (RO) with renal vein extension.
  • We identified seven ROs with extension into the branches of renal vein.
  • Renal vein extension was grossly suspected in 5/7 cases and histologically confirmed in all seven cases.
  • Tumor cells were positive for cytokeratins, mitochondrial antigen, epithelial membrane antigen, and parvalbumin; 5/7 tumors were focally positive for cluster of differentiation 117.
  • (1) renal oncocytomas may have intravascular extension to the branches of the renal vein;.
  • (2) renal oncocytomas with intravascular extension to the branches of the renal vein have the same morphological, immunohistochemical, and cytogenetic findings as have their counterparts without evidence of intravascular invasion;.
  • (3) the absence of metastases suggests an overall benign behavior of this tumor, but this has to be substantiated by further studies with a long-term follow-up;.
  • (4) in a renal tumor with granular cytoplasm showing renal vein extension, it is necessary to carefully exclude renal cell carcinomas (RCC) such as chromophobe RCC, oncocytic variant of papillary RCC, and granular variant of clear cell RCC.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Kidney / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers / analysis. Caenorhabditis elegans Proteins. Diagnosis, Differential. Female. Genome, Human. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Keratins / analysis. Loss of Heterozygosity. Male. Middle Aged. Mucin-1 / analysis. Mutation. Nucleic Acid Hybridization. Parvalbumins / analysis. Vacuolar Proton-Translocating ATPases. Von Hippel-Lindau Tumor Suppressor Protein / genetics

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  • (PMID = 18196270.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers; 0 / CAM 5.2 antigen; 0 / Caenorhabditis elegans Proteins; 0 / Mucin-1; 0 / Parvalbumins; 68238-35-7 / Keratins; EC 2.3.2.27 / Von Hippel-Lindau Tumor Suppressor Protein; EC 3.6.1.- / VHA-5 protein, C elegans; EC 3.6.1.- / Vacuolar Proton-Translocating ATPases; EC 6.3.2.- / VHL protein, human
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85. Feng G, Li G, Gentil-Perret A, Tostain J, Genin C: Elevated serum-circulating RNA in patients with conventional renal cell cancer. Anticancer Res; 2008 Jan-Feb;28(1A):321-6
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  • [Title] Elevated serum-circulating RNA in patients with conventional renal cell cancer.
  • BACKGROUND: Reliable serum biomarkers for differential diagnosis of conventional renal cell carcinoma (RCC) are highly desirable.
  • The purpose of our study was to evaluate whether the amounts of circulating RNA could discriminate between conventional renal cancer patients and healthy individuals as a tumor marker.
  • PATIENTS AND METHODS: A total of 71 patients with conventional RCC, 12 with renal oncocytomas and 44 healthy individuals entered into this study.
  • RESULTS: The mean level of RNA in conventional RCC (1414.19 +/- 91.95 ng/ml) was significantly higher than that in healthy individuals (520.49 +/- 39.75 ng/ml, p<0.0001) and these with renal oncocytomas (560.71 +/- 69.54 ng/ml, p<0.0001).
  • Among the conventional RCC, there was no significant difference in circulating RNA levels in terms of tumor stage, grade or size.
  • The area under the ROC curve was 0.956 (95% confidence interval, 0.923 to 0.989), indicating an acceptable sensitivity and specificity as a tumor marker.
  • CONCLUSION: The data suggest that elevated circulating RNA may be a valuable diagnostic tool for discriminating conventional RCC patients from normal individuals or from these with renal oncocytoma.
  • Elevated serum circulating RNA provides a new research area as biomarker for the diagnosis of conventional RCC.
  • [MeSH-major] Carcinoma, Renal Cell / blood. Kidney Neoplasms / blood. RNA, Neoplasm / blood
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / blood. Female. Humans. Male. Middle Aged. ROC Curve. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 18383864.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Neoplasm
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86. Henderson A, Douglas F, Perros P, Morgan C, Maher ER: SDHB-associated renal oncocytoma suggests a broadening of the renal phenotype in hereditary paragangliomatosis. Fam Cancer; 2009;8(3):257-60
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  • [Title] SDHB-associated renal oncocytoma suggests a broadening of the renal phenotype in hereditary paragangliomatosis.
  • Renal tumours are also increasingly being reported as component tumours in hereditary paragangliomatosis associated with mutations in SDHB.
  • We present the first reported case of a family in whom an individual shown to carry a mutation in SDHB developed a renal oncocytoma.
  • We review other reports of renal tumours associated with SDHB-associated hereditary paragangliomatosis and suggest that various histological subtypes of renal tumours are part of this condition.
  • This observation indicates that SDHB-associated hereditary paragangliomatosis is unlike most tumour predisposition syndromes associated with the development of renal tumours which are usually associated with specific histological sub-types.
  • The increasing recognition of the involvement of renal tumours in SDHB mutation carriers suggests that renal screening is likely to be valuable for these patients.
  • SDHB mutations should also be considered in the context of genetic testing when renal tumours, regardless of histopathology, present in families with other tumours consistent hereditary paraganglioma syndrome.
  • [MeSH-minor] Aged. Case-Control Studies. DNA Mutational Analysis. Female. Genetic Predisposition to Disease. Genotype. Head and Neck Neoplasms / genetics. Humans. Kidney Neoplasms / genetics. Male. Pedigree. Phenotype. Retroperitoneal Neoplasms / genetics. Thyroid Neoplasms / genetics

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  • (PMID = 19184535.001).
  • [ISSN] 1573-7292
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Iron-Sulfur Proteins
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87. Masoom S, Venkataraman G, Jensen J, Flanigan RC, Wojcik EM: Renal FNA-based typing of renal masses remains a useful adjunctive modality: evaluation of 31 renal masses with correlative histology. Cytopathology; 2009 Feb;20(1):50-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Renal FNA-based typing of renal masses remains a useful adjunctive modality: evaluation of 31 renal masses with correlative histology.
  • OBJECTIVES: Given the advances in renal imaging modalities in the recent years, a greater number of renal cell carcinomas (RCCs) with tumour size of <3 cm are being detected radiologically.
  • METHODS: A total of 31 cases of renal masses with available fine needle aspiration (FNA) material and concomitant histopathology details were retrieved.
  • They included 27 RCCs (17 clear cells, eight papillary and two chromophobe), one oncocytoma, one liposarcoma and two benign lesions - one xanthogranulomatous pyelonephritis (XPN) and one benign cyst.
  • RESULTS: There was excellent agreement between the FNA typing and the final diagnosis, with correct classification in 28 of 31 cases.
  • CONCLUSIONS: There is an excellent concordance (90.3%) between the FNA diagnosis and the final histological diagnosis, especially in RCCs.
  • [MeSH-major] Carcinoma, Renal Cell. Kidney / pathology. Kidney Neoplasms
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Early Diagnosis. Humans. Middle Aged

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  • (PMID = 18476991.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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88. Eiss D, Larousserie F, Mejean A, Ghouadni M, Merran S, Correas JM, Hélénon O: [Renal oncocytoma: CT diagnostic criteria revisited]. J Radiol; 2005 Dec;86(12 Pt 1):1773-82
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  • [Title] [Renal oncocytoma: CT diagnostic criteria revisited].
  • PURPOSE: To redefine and evaluate the computed tomographic criteria for the diagnosis of renal oncocytoma (RO) for which renal sparing surgery should be preferred.
  • A double blinded comparative study was made of 60 renal tumors (containing adenocarcinomas and oncocytomas) larger than 3 cm in diameter in order to evaluate the redefined CT diagnostic criteria.
  • RESULTS: Among RO larger than 3 cm in diameter, 55% presented a sharply defined low attenuation scar on post-contrast scans at the tubular nephrographic phase, central or eccentric, with homogeneous attenuation throughout the remainder of the hypervascular tumor which was classified in 3 different groups.
  • The use of our CT diagnostic criteria gave a statistically significant (p < 0.05) Kappa index of inter-observer concordance of 0.71 and a specificity of 96% for the diagnosis of RO.
  • CONCLUSION: Our redefined computed tomographic criteria for the diagnosis of renal oncocytoma, eventually associated with renal biopsy, should increase the indications for renal sparing surgery for RO larger than 3 cm in diameter.
  • [MeSH-major] Adenoma, Oxyphilic / radiography. Kidney Diseases / radiography. Tomography, X-Ray Computed


89. Mazal PR, Exner M, Haitel A, Krieger S, Thomson RB, Aronson PS, Susani M: Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma. Hum Pathol; 2005 Jan;36(1):22-8
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  • [Title] Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma.
  • Distinguishing renal oncocytoma from chromophobe and other renal carcinomas is essential, considering their differing biological potentials.
  • Although renal oncocytoma is considered a benign tumor, chromophobe renal cell carcinoma has potentially malignant biological behavior.
  • We report a novel immunohistochemical approach based on the expression of a recently described kidney-specific cadherin (Ksp-cadherin) for the differential diagnosis of these 2 tumors.
  • We compared Ksp-cadherin expression in 212 renal tumors, including 102 clear cell renal carcinomas, 46 papillary renal cell carcinomas, 30 chromophobe carcinomas, 3 collecting duct carcinomas, and 31 oncocytomas.
  • In addition, we examined the expression of epithelial membrane antigen, vimentin, CK7, and Hale's colloidal iron staining.
  • We found that chromophobe renal cell carcinomas consistently (96.7% of cases) demonstrated a distinctive membrane pattern of Ksp-cadherin expression, whereas renal oncocytomas (3.2%), clear cell renal cell carcinomas (0%), papillary renal cell carcinomas (2.2%), and collecting duct carcinomas (0%) usually did not express Ksp-cadherin.
  • CK7 expression was found in 90.0%, 6.5%, 7.8%, 76.1%, and 33.3% of these tumor cases, respectively.
  • Whereas CK7 was detected in different types of renal cell carcinomas, Ksp-cadherin was expressed almost exclusively in chromophobe renal cell carcinomas.
  • Immunohistochemical analysis of Ksp-cadherin offers a fast, reliable approach for the distinguishing between renal oncocytoma and chromophobe renal cell carcinoma that is applicable for routine pathology laboratory studies without the need for time-consuming and costly ancillary studies.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma, Papillary / metabolism. Adenoma, Oxyphilic / metabolism. Biomarkers, Tumor / analysis. Cadherins / biosynthesis. Kidney Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma, Clear Cell / metabolism. Adenocarcinoma, Clear Cell / pathology. Adolescent. Adult. Aged. Aged, 80 and over. Blotting, Western. Carcinoma, Renal Cell / metabolism. Carcinoma, Renal Cell / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Middle Aged


90. Mai KT, Dhamanaskar P, Belanger E, Stinson WA: Hybrid chromophobe renal cell neoplasm. Pathol Res Pract; 2005;201(5):385-9
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  • [Title] Hybrid chromophobe renal cell neoplasm.
  • Hybrid renal cell neoplasms (HRCNs) containing areas of tumor cells displaying cytological features of chromophobe renal cell carcinoma (CHRCC) and renal oncocytoma (RO) have been recently described in patients with renal oncocytosis and Birt-Hogg-Dube (BHD) syndrome (autosomal dominant genodermatosis).
  • We reviewed 425 consecutive renal cell carcinomas (RCC), 18 CHRCC, six HRCN, and 25 RO.
  • Areas of oncocytic cells in studied tumors and control oncocytomas showed negative or focal cytoplasmic staining usually bordering extra- or intra-cytoplasmic lumina.
  • None of the study cases had microscopic RO, as commonly seen in renal oncocytosis, or were associated with BHD syndrome Sporadic HRCN accounted for 1% of RCC.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology

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  • (PMID = 16047948.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / KRT7 protein, human; 0 / Keratin-7; 0 / Vimentin; 68238-35-7 / Keratins
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91. de la Cruz Burgos R, Martel Villagrán J: [Renal oncocytoma. Fundamental radiologic manifestations and enhancement patterns in tri-phase helical CT]. Radiologia; 2007 Mar-Apr;49(2):109-14
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  • [Title] [Renal oncocytoma. Fundamental radiologic manifestations and enhancement patterns in tri-phase helical CT].
  • [Transliterated title] Oncocitoma renal. Manifestaciones radiológicas fundamentales y patrones de captación en tomografía computarizada helicoidal trifásica.
  • OBJECTIVE: Oncocytoma is a relatively uncommon benign kidney tumor.
  • To date, it has been impossible to differentiate this tumor from renal cell carcinoma radiologically, although few articles report on the use of tri-phase CT in this tumor.
  • We describe the triphasic CT findings in these tumors and evaluate whether some characteristics, although not sufficient to ensure the diagnosis, can suggest the possibility of oncocytoma.
  • MATERIAL AND METHODS: We describe the tri-phase CT findings in 10 cases of oncocytoma in eight patients (one case was bilateral and multifocal).
  • The diagnosis was made after histological examination of surgical specimens in all cases.
  • CONCLUSIONS: Although oncocytoma cannot be differentiated from renal cell carcinoma with certainty, the possibility of oncocytoma should be suggested in the case of small tumors with a central scar, without necrosis or infiltration, and an enhancement pattern as described here.
  • Regardless of the size of the tumor, lobular morphology should also suggest this possibility.
  • [MeSH-major] Adenoma, Oxyphilic / radiography. Kidney Neoplasms / radiography. Tomography, Spiral Computed

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  • (PMID = 17403340.001).
  • [ISSN] 0033-8338
  • [Journal-full-title] Radiología
  • [ISO-abbreviation] Radiologia
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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92. Westermann DH, Rüdiger T, Lohe B, Frohneberg D: [Birt-Hogg-Dubé syndrome : bilateral oncocytic kidney tumors in a patient]. Urologe A; 2010 Dec;49(12):1527-31
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  • [Title] [Birt-Hogg-Dubé syndrome : bilateral oncocytic kidney tumors in a patient].
  • [Transliterated title] Birt-Hogg-Dubé-Syndrom : Bilateraler onkozytischer Hybridtumor der Niere.
  • We report on a rare case of bilateral oncocytic kidney tumors in a patient with Birt-Hogg-Dubé syndrome (BHD).
  • BHD is an autosomal inherited cancer syndrome associated with multiple kidney tumors, benign cutaneous tumors, and pulmonary cysts with spontaneous pneumothorax.
  • Close follow-up is mandatory because recurrence in previously operated kidneys and metastatic tumor progression can occur.
  • [MeSH-major] Birt-Hogg-Dube Syndrome / diagnosis. Birt-Hogg-Dube Syndrome / surgery. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / surgery
  • [MeSH-minor] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / surgery. Humans. Kidney Neoplasms / diagnosis. Kidney Neoplasms / surgery. Male. Middle Aged. Syndrome. Treatment Outcome

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  • (PMID = 20949256.001).
  • [ISSN] 1433-0563
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] Oncocytoma, renal
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93. Delongchamps NB, Galmiche L, Eiss D, Rouach Y, Vogt B, Timsit MO, Vieillefond A, Méjean A: Hybrid tumour 'oncocytoma-chromophobe renal cell carcinoma' of the kidney: a report of seven sporadic cases. BJU Int; 2009 May;103(10):1381-4
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  • [Title] Hybrid tumour 'oncocytoma-chromophobe renal cell carcinoma' of the kidney: a report of seven sporadic cases.
  • OBJECTIVES: To determine whether renal hybrid tumours (HT) appear as a specific clinical and radiological entity, as HT are characterized by the association of both oncocytes and chromophobe cells within the same tumour, and have been described in patients with oncocytosis and Birt-Hogg-Dube syndrome.
  • PATIENTS AND METHODS: We reviewed the medical charts of 67 patients who had a partial or radical nephrectomy in our institution for renal oncocytoma (RO, 24), chromophobe renal cell carcinoma (CRCC, 36) and HT (seven), from January 2006 to October 2007.
  • Two patients had a history of kidney cancer.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Nephrectomy / methods. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Aged. Female. Genetic Predisposition to Disease. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis


94. Liu L, Qian J, Singh H, Meiers I, Zhou X, Bostwick DG: Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: an optimal and practical panel for differential diagnosis. Arch Pathol Lab Med; 2007 Aug;131(8):1290-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: an optimal and practical panel for differential diagnosis.
  • CONTEXT: The separation of chromophobe renal cell carcinoma, oncocytoma, and clear cell renal cell carcinoma using light microscopy remains problematic in some cases.
  • OBJECTIVE: To determine a practical immunohistochemical panel for the differential diagnosis of chromophobe carcinoma.
  • DESIGN: Vimentin, glutathione S-transferase alpha (GST-alpha), CD10, CD117, cytokeratin (CK) 7, and epithelial cell adhesion molecule (EpCAM) were investigated in 22 cases of chromophobe carcinoma, 17 cases of oncocytoma, and 45 cases of clear cell carcinoma.
  • CD10 staining was more frequently detected in clear cell carcinoma (91%) than in chromophobe carcinoma (45%) and oncocytoma (29%).
  • CD117 was strongly expressed in chromophobe carcinoma (82%) and oncocytoma (100%), whereas none of the cases of clear cell carcinomas were immunoreactive.
  • CONCLUSIONS: Using the combination of 3 markers (vimentin, GST-alpha, and EpCAM), we achieved 100% sensitivity and 100% specificity for the differential diagnosis of chromophobe carcinoma, oncocytoma, and clear cell carcinoma.
  • The pattern of "vimentin(-)/GST-alpha(-)" effectively excluded clear cell carcinoma, and homogeneous EpCAM expression confirmed the diagnosis of chromophobe carcinoma rather than oncocytoma.
  • CD117 and CK7 were also useful markers and could be used as second-line markers for the differential diagnosis, with high specificity (100%) and high sensitivity (90% and 86%, respectively).
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Adenoma, Oxyphilic / diagnosis. Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / diagnosis. Immunoenzyme Techniques / methods. Kidney Neoplasms / diagnosis. Neoplasm Proteins / analysis
  • [MeSH-minor] Diagnosis, Differential. Fluorescent Antibody Technique, Indirect. Humans. Predictive Value of Tests


95. Rao Q, Liu XH, Zhou HB, Ma HH, Lu ZF, Zhou XJ: Expression analysis of Wnt-5a in renal epithelial neoplasms: distinguishing renal oncocytoma from a wide spectrum of renal cell carcinomas. Tumori; 2010 Mar-Apr;96(2):304-9
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  • [Title] Expression analysis of Wnt-5a in renal epithelial neoplasms: distinguishing renal oncocytoma from a wide spectrum of renal cell carcinomas.
  • OBJECTIVE: To study the expression of a novel marker, Wnt-5a, in renal epithelial neoplasms and determine its clinicopathological significance.
  • METHODS: Immunohistochemical analysis of Wnt-5a was carried out in normal human kidney samples as well as in 123 primary renal epithelial neoplasms including 37 clear cell renal cell carcinomas (RCCs), 24 papillary RCCs (15 type 1 and 9 type 2), 25 chromophobe RCCs, 11 Xp11 translocation carcinomas, 6 mucinous tubular and spindle cell carcinomas, and 20 oncocytomas.
  • There was a significant difference in Wnt-5a immunohistochemistry between renal oncocytoma and the other subtypes of RCC (P < 0.01).
  • CONCLUSIONS: Our results indicate that Wnt-5a is a potentially useful immunohistochemical marker for the complex differential diagnosis between oncocytoma and other subtypes of RCC and also suggest that Wnt-5a may be a tumor suppressor gene in RCC.
  • [MeSH-major] Adenoma, Oxyphilic / chemistry. Carcinoma, Renal Cell / chemistry. Kidney Neoplasms / chemistry. Neoplasms, Glandular and Epithelial / chemistry. Proto-Oncogene Proteins / analysis. Wnt Proteins / analysis
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Wnt-5a Protein

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  • (PMID = 20572590.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins; 0 / WNT5A protein, human; 0 / Wnt Proteins; 0 / Wnt-5a Protein
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96. Theodosopoulos T, Yiallourou A, Kyriazi M, Anastasopoulos G, Kairi-Vassilatou E, Dafnios N, Vassiliou I: Unilateral simultaneous renal oncocytoma and angiomyolipoma: case report. Cases J; 2009;2:9093
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  • [Title] Unilateral simultaneous renal oncocytoma and angiomyolipoma: case report.
  • A rare case of synchronous angiomyolipoma and oncocytoma in the same kidney of a 70 year old man is presented.
  • A left renal mass was found incidentally by ultrasound.
  • Computerized tomography and magnetic resonance imaging revealed a 1,3 cm mass in the mid-portion of the left kidney, whereas on the lower pole of the same kidney, a 3,3 cm mass was also revealed, consistent with angiomyolipoma.
  • A working diagnosis of renal cell carcinoma was made.
  • Microscopically, the tumor of the lower pole was found to be an angiomyolipoma, whereas the mid-portion tumor was an oncocytoma.
  • Until now, only 16 cases of unilateral simultaneous presence of renal angiomyolipoma and oncocytoma have been reported.
  • It is well worth remarking, that renal oncocytoma overlap with other renal neoplasms, therefore nephrectomy remains the treatment of choice.Renal angiomyolipoma and oncocytoma are uncommon neoplasms and their simultaneous presence in the same kidney is rare.

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  • (PMID = 20062730.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803890
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97. Magro G, Gardiman MP, Lopes MR, Michal M: Small-cell variant of renal oncocytoma with dominating solid growth pattern: a potential diagnostic pitfall. Virchows Arch; 2006 Mar;448(3):379-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Small-cell variant of renal oncocytoma with dominating solid growth pattern: a potential diagnostic pitfall.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Carcinoma, Small Cell / diagnosis. Carcinoma, Small Cell / secondary. Diagnosis, Differential. Female. Humans. Kidney / diagnostic imaging. Middle Aged. Nephrectomy. Radiography. Treatment Outcome. Ultrasonography

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  • [Cites] Int J Surg Pathol. 2001 Jul;9(3):215-22 [11584318.001]
  • [Cites] Am J Surg Pathol. 1997 Jan;21(1):1-12 [8990136.001]
  • [Cites] Am J Surg Pathol. 1997 Aug;21(8):871-83 [9255250.001]
  • (PMID = 16292662.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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98. Yusenko MV: Molecular pathology of renal oncocytoma: a review. Int J Urol; 2010 Jul;17(7):602-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular pathology of renal oncocytoma: a review.
  • Differentiating renal oncocytoma from its renal cell carcinoma (RCC) mimics, particularly chromophobe RCC, can be difficult, especially when limited tissue is available for evaluation and requires sophisticated microscopic, ultrastructural and immunohistochemical evaluation.
  • In this review, the relevant literature has been reviewed, and supporting data obtained by applying modern microarray-based technologies are discussed with a focus on molecular pathology of renal oncocytoma.
  • Renal oncocytomas are characterized by variable chromosomal patterns.
  • Applying DNA based tools might help in the diagnosis of renal oncocytoma with uncertain histology.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Adenoma, Oxyphilic / pathology. Kidney Neoplasms / genetics. Kidney Neoplasms / pathology

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  • [CommentIn] Int J Urol. 2010 Jul;17(7):612-3 [20590945.001]
  • [CommentIn] Int J Urol. 2010 Jul;17(7):613-4 [20590946.001]
  • [ErratumIn] Int J Urol. 2011 Aug;18(8):614
  • (PMID = 20590944.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Australia
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99. Alvarez Ardura M, Hernández Cañas V, de la Morena Gallego JM, Rengifo Abbad D, González-Chamorro Ladrón de Guevara F, Llorente Abarca C: [Giant renal oncocytoma]. Actas Urol Esp; 2005 Sep;29(8):791-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Giant renal oncocytoma].
  • [Transliterated title] Oncocitoma renal gigante.
  • Renal oncocytoma is a benign neoplasms arising from cells of the distal renal tubule.
  • They acount for 3-7% of all renal tumors. most are incidental findings.
  • Differential diagnosis with renal cells carcinoma is often difficult.
  • Here we report a case of big renal oncocytoma as an incidental finding while performing an abdominal ultrasound in a patient with low abdominal pain.
  • [MeSH-major] Adenoma, Oxyphilic / diagnostic imaging. Kidney Neoplasms / diagnostic imaging

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  • (PMID = 16304913.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas espanolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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100. McHugh JB, Hoschar AP, Dvorakova M, Parwani AV, Barnes EL, Seethala RR: p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma. Head Neck Pathol; 2007 Dec;1(2):123-31
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  • [Title] p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma.
  • Metastatic renal cell carcinoma (RCC) can pose diagnostic challenges in the head and neck often resembling benign and malignant oncocytic lesions.
  • Nineteen oncocytomas, 9 cases of oncocytosis, 9 oncocytic carcinomas and 16 head and neck metastatic RCC were studied.
  • Morphologic features evaluated were cytoplasmic character (clear versus oncocytic), Fuhrman nuclear grade, mitotic rate, growth pattern, presence of lumens/blood lakes and stromal characteristics.
  • Tumors were stained with antibodies to p63, renal cell carcinoma marker (RCCm), CD10, and vimentin.
  • Eight benign oncocytic tumors (29%) had clear cell features while 6 metastatic RCC (37%) had oncocytic features.
  • Median Fuhrman nuclear grade was 2 in oncocytoma and oncocytosis and 3 both oncocytic carcinoma and metastatic RCC.
  • Mitotic rates were only significantly different between benign oncocytic tumors and metastatic RCC.
  • Seven benign oncocytic tumors (25%) and 5 oncocytic carcinomas (56%) had RCC-like vascular stroma.
  • While clinical history and morphology usually are adequate, demonstration of p63 staining can definitively exclude metastatic RCC from the differential diagnosis of similar appearing tumors in salivary glands, namely oncocytoma and oncocytic carcinoma, with 100% specificity and sensitivity.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Membrane Proteins / metabolism. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Predictive Value of Tests

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  • (PMID = 20614263.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Membrane Proteins
  • [Other-IDs] NLM/ PMC2807526
  • [Keywords] NOTNLM ; Metastatic renal cell carcinoma / Oncocytic carcinoma / Oncocytoma / p63
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