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1. Picken MM: Editorial comment from Dr Picken to Molecular pathology of renal oncocytoma: a review. Int J Urol; 2010 Jul;17(7):613-4
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  • [Title] Editorial comment from Dr Picken to Molecular pathology of renal oncocytoma: a review.
  • [MeSH-major] Adenoma, Oxyphilic. Kidney Neoplasms

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  • [CommentOn] Int J Urol. 2010 Jul;17(7):602-12 [20590944.001]
  • (PMID = 20590946.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] Australia
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2. Tamai H, Takiguchi Y, Oka M, Shingaki N, Enomoto S, Shiraki T, Furuta M, Inoue I, Iguchi M, Yanaoka K, Arii K, Shimizu Y, Nakata H, Shinka T, Sanke T, Ichinose M: Contrast-enhanced ultrasonography in the diagnosis of solid renal tumors. J Ultrasound Med; 2005 Dec;24(12):1635-40
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  • [Title] Contrast-enhanced ultrasonography in the diagnosis of solid renal tumors.
  • OBJECTIVE: The purpose of this study was to evaluate the usefulness of contrast-enhanced ultrasonography (CEUS) in the diagnosis of solid renal tumors.
  • METHODS: Twenty-nine patients with solid tumors detected on gray scale ultrasonography underwent resection for suspected renal malignancy.
  • Findings of arterial phase contrast computed tomography (CT) and CEUS were compared for each diagnosis.
  • RESULTS: Histopathologic examination of resected lesions showed malignancy in 26 patients (clear cell carcinoma, n = 18; papillary renal cell carcinoma, n = 6; collecting duct carcinoma, n = 1; and infiltrative urothelial carcinoma, n = 1) and benign tumors in 3 patients (oncocytoma, n = 2; and angiomyolipoma, n = 1).
  • Contrast CT failed to show tumor blood flow in 5 of 29 patients, whereas CEUS showed this in all patients.
  • Positive predictive values of CEUS and contrast CT in the diagnosis of renal malignancy were 100% and 82.8%, respectively.
  • However, CEUS showed blood flow in these lesions, leading to diagnosis of hypovascular renal tumors.
  • CONCLUSIONS: Contrast-enhanced ultrasonography was more sensitive for detecting slight tumor blood flow than contrast CT and was useful in preoperatively diagnosing malignant hypovascular renal tumors but was less so for hypervascular renal tumors.
  • [MeSH-major] Contrast Media. Image Enhancement / methods. Kidney Neoplasms / radiography. Kidney Neoplasms / ultrasonography. Neovascularization, Pathologic / radiography. Neovascularization, Pathologic / ultrasonography. Ultrasonography / methods

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  • (PMID = 16301719.001).
  • [ISSN] 0278-4297
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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3. Anastasiadis A, Dimitriadis G, Radopoulos D: Incidental giant renal oncocytoma: a case report. J Med Case Rep; 2010;4:358
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  • [Title] Incidental giant renal oncocytoma: a case report.
  • INTRODUCTION: Large renal oncocytomas are not very rare entities.
  • The tumor was incidentally diagnosed and, based on the preoperative clinical and radiographic findings, was therefore considered to be a renal cell carcinoma.
  • CASE PRESENTATION: A 48-year-old Caucasian diabetic man had an abdominal ultrasound for chronic abdominal discomfort, which revealed a large mass on the left kidney.
  • A magnetic resonance imaging scan was performed with no evidence of renal vein or caval thrombus or embolus.
  • A radical nephrectomy was performed through a left flank intercostal incision and the pathology diagnosed renal oncocytoma.
  • CONCLUSION: Several reports have characterised this essentially benign renal histiotype, which represents 5% to 7% of all solid renal masses.
  • Unfortunately, most renal oncocytomas cannot be differentiated from malignant renal cell carcinomas by clinical or radiographic criteria.
  • We report on, to the best of our knowledge, the fourth largest lesion of this type of renal pathology.

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  • (PMID = 21059248.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2990760
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4. Roy C, Gengler L, Sauer B, Lang H: [Role of contrast enhanced US in the evaluation of renal tumors]. J Radiol; 2008 Nov;89(11 Pt 1):1735-44
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  • [Title] [Role of contrast enhanced US in the evaluation of renal tumors].
  • [Transliterated title] Rôle de l'échographie de contraste dans l'évaluation des tumeurs rénales.
  • PURPOSE: To evaluate the role of contrast enhanced US in the characterization of renal tumors.
  • Eighty-six renal tumors (33 solid, 53 cystic) underwent contrast enhanced US after indeterminate CT/MRI (67 lesions) or US (19 lesions).
  • Diagnosis was achieved in 21 cases.
  • Lesions included: 19 renal cell carcinomas (4 conventional, 14 papillary, 1 tubulocystic), 5 oncocytomas, 3 metastases, 6 pseudomasses, and 53 cystic lesions including 6 malignant tumors.
  • Characterization of solid tumors was possible with specificity of 92.9% for papillary carcinoma, 57.1% for clear cell carcinoma, and 100% for oncocytoma.
  • The specificity for distinguishing solid benign from solid malignant tumor was 100% based on the presence of hypoechogenicity relative to normal renal parenchyma on delayed imaging.
  • CONCLUSION: Contrast enhanced US is easily performed in clinical practice and allows improved characterization of some renal tumors compared to other cross sectional imaging techniques.
  • [MeSH-major] Contrast Media. Kidney Neoplasms / ultrasonography

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  • (PMID = 19106830.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Multicenter Study
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Contrast Media
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5. Fiske J, Patel R, Kau E, Pappas JG, Garcia RA, Taneja SS: Multifocal renal oncocytoma in a patient with Von Hippel-Lindau mutation. Urology; 2005 Dec;66(6):1320
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  • [Title] Multifocal renal oncocytoma in a patient with Von Hippel-Lindau mutation.
  • Von Hippel-Lindau disease (VHL) is a rare genetic disease with a lifetime risk of clear cell renal cell carcinoma in approximately 70% of cases.
  • We present a case of a 63-year-old man with bilateral, multifocal renal masses.
  • Pathology of all renal masses revealed oncocytoma.
  • To our knowledge, we describe the first reported case of multiple renal oncocytomas in a male patient with a germline VHL mutation.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Kidney Neoplasms / genetics. von Hippel-Lindau Disease / genetics


6. Burger M, Denzinger S, Filbeck T, Hartmann A, Rössler W, Hammerschmied C: A metachronous, atypical, multifocal renal oncocytoma with a concomitant renal cell carcinoma of the contralateral side and bilateral multifocal oncocytomas: two case reports and review of literature. ScientificWorldJournal; 2005 Jul 20;5:545-9
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  • [Title] A metachronous, atypical, multifocal renal oncocytoma with a concomitant renal cell carcinoma of the contralateral side and bilateral multifocal oncocytomas: two case reports and review of literature.
  • We present one case of a metachronous, atypical, multifocal renal oncocytoma with a concomitant chromophobe renal cell carcinoma (RCC) of the contralateral side and one case of bilateral and multifocal oncocytomas.
  • Oncocytomas are benign renal tumours that rarely appear bilateral or multifocal or with coexisting RCC.
  • The first case was a 63 years old patient presenting with a history of nephrectomy for a pT1 G1 pN0 R0 papillary RCC 4 years prior to presentation, showed two tumours of a singular kidney.
  • Upon nephron-sparing surgery one typical and one atypical oncocytoma with an invasion of the perinephric fat were found.
  • The second case was a 62 years old patient presenting with multifocal and bilateral renal tumours of undeclared dignity upon imaging.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Neoplasms, Second Primary / pathology
  • [MeSH-minor] Chromosome Deletion. Chromosomes, Human, Pair 1 / ultrastructure. Chromosomes, Human, Pair 10 / ultrastructure. DNA, Neoplasm / genetics. Diagnosis, Differential. Follow-Up Studies. Humans. Incidental Findings. Middle Aged. Nephrectomy / methods. Nucleic Acid Hybridization. Remission Induction

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  • (PMID = 16075151.001).
  • [ISSN] 1537-744X
  • [Journal-full-title] TheScientificWorldJournal
  • [ISO-abbreviation] ScientificWorldJournal
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm
  • [Number-of-references] 12
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7. Alamara C, Karapanagiotou EM, Tourkantonis I, Xyla V, Maurer CC, Lykourinas M, Pandha H, Syrigos KN: Renal oncocytoma: a case report and short review of the literature. Eur J Intern Med; 2008 Nov;19(7):e67-9
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  • [Title] Renal oncocytoma: a case report and short review of the literature.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Kidney Neoplasms / pathology

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  • (PMID = 19013370.001).
  • [ISSN] 1879-0828
  • [Journal-full-title] European journal of internal medicine
  • [ISO-abbreviation] Eur. J. Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 14
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8. Prager GW, Poettler M, Schmidinger M, Mazal PR, Susani M, Zielinski CC, Haitel A: CD98hc (SLC3A2), a novel marker in renal cell cancer. Eur J Clin Invest; 2009 Apr;39(4):304-10
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  • [Title] CD98hc (SLC3A2), a novel marker in renal cell cancer.
  • Especially in renal cell cancer (RCC), tyrosine kinase-inhibitors have been established as useful and highly effective therapy.
  • RESULTS: We found increased CD98hc expression in different types of malign RCCs, among them clear cell (cc)RCC, papillary (p)RCC and chromophobe (ch)RCC, but lack of expression in the benign renal oncocytoma.
  • [MeSH-major] Antigens, CD98 Heavy Chain / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis

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  • (PMID = 19292886.001).
  • [ISSN] 1365-2362
  • [Journal-full-title] European journal of clinical investigation
  • [ISO-abbreviation] Eur. J. Clin. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD98 Heavy Chain; 0 / Biomarkers, Tumor
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9. Reichelt O, Gajda M, Chyhrai A, Wunderlich H, Junker K, Schubert J: Ultrasound-guided biopsy of homogenous solid renal masses. Eur Urol; 2007 Nov;52(5):1421-6
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  • [Title] Ultrasound-guided biopsy of homogenous solid renal masses.
  • OBJECTIVES: We evaluated the reliability of sonographic criteria in selecting solid renal masses for percutaneous fine-needle biopsy.
  • The main tumor was intraoperatively evaluated by B-mode and power Doppler sonography.
  • Morphologic characteristics seen on ultrasound were categorized in (non-)homogenous and (non-)cystic renal masses and were related to findings of pathological examination.
  • RESULTS: In the ultrasound study, only 16 (22.9%) of the 76 clear-cell carcinomas but all 9 (100%) oncocytoma appeared homogenous and noncystic on high-resolution intraoperative ultrasound.
  • By applying these results to 30 patients of study 2 (18 men, 12 women; aged 63+/-7.7 yr, tumor size 29+/-11.3mm) who met these sonographic criteria on preoperative transabdominal ultrasound, we bioptically diagnosed 8 (26.7%) benign tumors; 25 of 30 (83.3%) patients were accurately diagnosed.
  • Small tumors (<3cm), decreased breathing compliance, and medially located renal lesions seem to negatively influence biopsy results.
  • CONCLUSIONS: Kidney tumors that appear noncystic and homogenous on preoperative ultrasound are more likely to be of benign origin.
  • Ultrasound-guided percutaneous biopsy of these solid renal masses could determine renal tumor patients for whom surveillance might be an option.
  • However, experienced and dedicated histopathologic evaluation remains crucial to observe patients with clearly benign biopsy results.
  • [MeSH-major] Biopsy / methods. Kidney Neoplasms / pathology. Ultrasonography, Doppler / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Staging / methods. Nephrectomy / methods. Prospective Studies. Reproducibility of Results


10. Shakarchi JA, Wharton I, Youssef A, Anderson P: Giant renal oncocytoma. Radiol Case Rep; 2009;4(3):307
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  • [Title] Giant renal oncocytoma.
  • We present the case of a 70-year-old male who presented with a large lesion in the right kidney, which was noticed on ultrasonography.
  • CT confirmed the large tumor, and both clinical and radiological findings raised suspicion of a renal cell carcinoma.

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  • (PMID = 27307826.001).
  • [ISSN] 1930-0433
  • [Journal-full-title] Radiology case reports
  • [ISO-abbreviation] Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC4897999
  • [Keywords] NOTNLM ; CT, computed tomography / MRI, magnetic resonance imaging
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11. Zisman A, Patard JJ, Raz O, Klatte T, Haifler M, Mendlovic S, Sandbank J, Belldegrun AS, Lindner A, Leibovici D, Pantuck AJ: Sex, age, and surgeon decision on nephron-sparing surgery are independent predictors of renal masses with benign histologic findings--a multicenter survey. Urology; 2010 Sep;76(3):541-6
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  • [Title] Sex, age, and surgeon decision on nephron-sparing surgery are independent predictors of renal masses with benign histologic findings--a multicenter survey.
  • OBJECTIVES: To define the preoperative independent predictors indicating that renal mass has benign histologic features.
  • METHODS: A total of 1664 patients with Stage T1-T2N0M0 with a unilateral renal mass underwent nephrectomy.
  • The endpoint at multivariate analysis was benign versus malignant histologic features.
  • RESULTS: The surgical approach (odds ratio [OR] 2.9, P = .0001), sex (OR 1.97, P = .0001), and age (OR 1.01, P = .007) were independent predictors for the malignant-benign distinction.
  • A weak relationship was found between an increasing tumor size and malignancy risk in men only.
  • High-grade renal cell carcinoma was more prevalent in men (31% versus 21%, P = .001).
  • The histologic tumor types were distributed differently between the 2 sexes: 8% papillary renal cell carcinoma in women versus 16% in men, 86% and 78% clear cell renal cell carcinoma, 33% and 57% oncocytoma, and 40% versus 12% angiomyolipoma, respectively.
  • The physician's preoperative judgment regarding tumor amenability for nephron-sparing surgery resulted in patient selection: 10% benign tumors for radical nephrectomy versus 25% for partial nephrectomy (P = .001) and 31% versus 20% high-grade tumors, respectively (P = .0001).
  • CONCLUSIONS: Renal tumors were consistently benign in 20% of women, regardless of size.
  • In contrast, in men, the malignancy risk increased slightly with tumor size.
  • The surgeons' preoperative decision regarding nephron-sparing surgery caused a selection bias in favor of benign lesions, regardless of sex.
  • Such changes could alter current practice and limit treatment of histologically proven benign lesions to surveillance or ablation only.
  • [MeSH-major] Kidney Neoplasms / pathology. Kidney Neoplasms / surgery. Nephrectomy

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • [CommentIn] Urology. 2010 Sep;76(3):546-7; discussion 547 [20832600.001]
  • (PMID = 20494411.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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12. Bensalah K, Tuncel A, Peshwani D, Zeltser I, Liu H, Cadeddu J: Optical reflectance spectroscopy to differentiate renal tumor from normal parenchyma. J Urol; 2008 May;179(5):2010-3
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  • [Title] Optical reflectance spectroscopy to differentiate renal tumor from normal parenchyma.
  • PURPOSE: Optical spectroscopy has been evaluated as an innovative technique for the ex vivo study of renal and prostate tumors.
  • In this pilot study we assessed the ability of optical reflectance spectroscopy to reliably differentiate tumor and normal tissue in renal specimens.
  • MATERIALS AND METHODS: From January to April 2007 we completed optical reflectance spectroscopy measurements at several standardized tumor and normal parenchymal locations immediately after kidney tumor removal.
  • The slopes of the optical reflectance spectroscopy curves were compared, and the correlation between tumor and normal parenchyma reflectance was assessed.
  • Histology was malignant in 15 cases (clear cell in 14 and papillary in 1) and benign in 6 cases of oncocytoma.
  • Overall we found a significant difference between the average optical reflectance spectroscopy slopes of tumor and normal parenchyma (p = 0.03).
  • In individual radical nephrectomy specimens optical reflectance spectroscopy measurements at different locations in the tumor showed an excellent correlation (r = 0.968).
  • Normal parenchymal measurements also correlated well (r = 0.88), although there was poor correlation between tumor and nontumor tissue in the specimen (r = 0.07).
  • In the partial nephrectomy subset we also found a close correlation among measurements made on the normal parenchymal margin of the tumor (r = 0.94) except in 1 case of a positive margin (oncocytoma), in which the measurement from the positive margin site did not correlate with that of the adjacent parenchymal margin (r = 0.48).
  • CONCLUSIONS: Optical reflectance spectroscopy can help distinguish tumor from normal renal tissue in specimens immediately removed at surgery.
  • [MeSH-major] Kidney Neoplasms / diagnosis. Spectrum Analysis / methods
  • [MeSH-minor] Humans. Kidney / pathology. Nephrectomy

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  • (PMID = 18355850.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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13. Dhingra S, Nada R, Rayat CS, Joshi K: Unusual eosinophilic variant of chromophobe cell renal carcinoma--an ultrastructural diagnosis. Indian J Pathol Microbiol; 2005 Apr;48(2):255-7
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  • [Title] Unusual eosinophilic variant of chromophobe cell renal carcinoma--an ultrastructural diagnosis.
  • A case of eosinophilic variant of chromophobe cell renal carcinoma (EVCCRC), an uncommon variety of renal cell carcinoma, occurred in a 72 year old male.
  • The most problematic differential diagnosis was renal oncocytoma, as the two entities share overlapping features on histology, yet differ completely in biological behavior.
  • EVCCRC is a potentially malignant neoplasm whereas renal oncocytoma is totally benign.
  • The diagnosis was confirmed by ultrastructural examination of the tumor which revealed unique features of EVCCRC like presence of numerous cytoplasmic microvesicles along with mitochondria displaying tubulo-vesicular cristae.
  • This case delineates the role of electron microscopic examination as the sole means to differentiate EVCCRC from renal oncocytomas.
  • [MeSH-major] Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / ultrastructure. Eosinophils / pathology. Kidney Neoplasms / diagnosis. Kidney Neoplasms / ultrastructure


14. Kochhar R, Brown RK, Wong CO, Dunnick NR, Frey KA, Manoharan P: Role of FDG PET/CT in imaging of renal lesions. J Med Imaging Radiat Oncol; 2010 Aug;54(4):347-57
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  • [Title] Role of FDG PET/CT in imaging of renal lesions.
  • Focal incidental renal lesions are commonly encountered on positron emission tomography (PET)/computed tomography (CT) imaging.
  • The vast majority of these lesions are benign.
  • However, the interpretation of renal lesions can be problematic if the imaging criteria of simple cysts are not met.
  • Limited literature exists on the characterisation of renal masses with metabolic imaging.
  • The purpose of this article is to focus on the imaging features of benign and malignant renal masses with PET/CT.
  • The lesions discussed include renal cyst, angiomyolipoma, oncocytoma, renal cell carcinoma, renal metastases and other infiltrating neoplastic processes affecting the kidney.
  • Both the anatomical and metabolic features which characterise these benign and malignant entities are described.
  • We emphasise the importance of viewing the CT component to identify the typical morphological features and discuss how to best use hybrid imaging for management of renal lesions.
  • Metabolic imaging has a promising role in the imaging of renal lesions and can help prevent unnecessary biopsies and ensure optimal management of suspicious lesions.
  • [MeSH-major] Carcinoma, Renal Cell / diagnosis. Fluorodeoxyglucose F18. Kidney Neoplasms / diagnosis. Positron-Emission Tomography / methods. Radiopharmaceuticals. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adenoma, Oxyphilic / diagnosis. Angiomyolipoma / diagnosis. Cysts / diagnosis. Humans. Incidental Findings. Kidney / radiography. Kidney / radionuclide imaging. Kidney Diseases / diagnosis. Leukemia / diagnosis. Lymphoma / diagnosis

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  • (PMID = 20718915.001).
  • [ISSN] 1754-9485
  • [Journal-full-title] Journal of medical imaging and radiation oncology
  • [ISO-abbreviation] J Med Imaging Radiat Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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15. Rogers C, Laungani R, Krane LS, Bhandari A, Bhandari M, Menon M: Robotic nephrectomy for the treatment of benign and malignant disease. BJU Int; 2008 Dec;102(11):1660-5
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  • [Title] Robotic nephrectomy for the treatment of benign and malignant disease.
  • Radical nephrectomy (RN) was performed for suspected malignant disease and simple nephrectomy (SN) was performed for benign disease.
  • Renal hilar vessels were controlled using robotic suture ligation (25), robotic haemolock clips (12), or laparoscopic staplers (five).
  • On final tumour pathology, the RN specimens included 34 renal cell carcinomas (clear cell 23, papillary nine, chromophobe two) and an oncocytoma.
  • CONCLUSIONS: Robotic nephrectomy is a safe and feasible option for minimally invasive surgical removal of the kidney for benign and malignant conditions and can be performed through a transperitoneal or retroperitoneal approach.
  • [MeSH-major] Kidney Diseases / surgery. Nephrectomy / methods. Robotics

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  • [CommentIn] BJU Int. 2009 Mar;103(6):842; author reply 842 [19260854.001]
  • (PMID = 18671787.001).
  • [ISSN] 1464-410X
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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16. Russo P: Open partial nephrectomy: an essential operation with an expanding role. Curr Opin Urol; 2007 Sep;17(5):309-15
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  • PURPOSE OF REVIEW: To describe the rationale for expanding the role of partial nephrectomy in the treatment of renal cortical tumors.
  • RECENT FINDINGS: Renal tumors are a family of neoplasms ranging from the benign oncocytoma, to the indolent papillary and chromophobe carcinomas, to the more potentially malignant clear cell carcinomas that account for 54% of the lesions resected, but 90% of those that metastasize.
  • Due to a contemporary stage migration, 70% of the tumors are detected incidentally with a median tumor size of below 4.0 cm.
  • Partial nephrectomy for tumors of 7 cm or less provides equivalent oncological tumor control to radical nephrectomy with maximum preservation of long-term renal function.
  • Twenty-six percent of patients prior to operation already have stage 3 chronic kidney disease with an estimated glomerular filtration rate of less than 60 ml/min/1.73 m.
  • Chronic kidney disease is an independent risk factor for the development of cardiovascular disease, hospitalization and death.
  • SUMMARY: Partial nephrectomy is an essential surgical approach to the small kidney tumor and provides equivalent local tumor control while preventing the new onset or worsening of chronic kidney disease.
  • [MeSH-major] Kidney Cortex / surgery. Kidney Neoplasms / surgery. Nephrectomy / methods. Renal Insufficiency, Chronic / prevention & control
  • [MeSH-minor] Cardiovascular Diseases / etiology. Cardiovascular Diseases / prevention & control. Glomerular Filtration Rate. Humans. Neoplasm Staging. Patient Selection. Risk Assessment. Risk Factors. Treatment Outcome

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  • (PMID = 17762622.001).
  • [ISSN] 0963-0643
  • [Journal-full-title] Current opinion in urology
  • [ISO-abbreviation] Curr Opin Urol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 48
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17. Brunelli M, Eble JN, Zhang S, Martignoni G, Delahunt B, Cheng L: Eosinophilic and classic chromophobe renal cell carcinomas have similar frequent losses of multiple chromosomes from among chromosomes 1, 2, 6, 10, and 17, and this pattern of genetic abnormality is not present in renal oncocytoma. Mod Pathol; 2005 Feb;18(2):161-9
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  • [Title] Eosinophilic and classic chromophobe renal cell carcinomas have similar frequent losses of multiple chromosomes from among chromosomes 1, 2, 6, 10, and 17, and this pattern of genetic abnormality is not present in renal oncocytoma.
  • That chromophobe renal cell carcinoma has an uncommon eosinophilic variant has been recognized for more than a decade.
  • In sections stained with hematoxylin and eosin, the eosinophilic variant of chromophobe renal cell carcinoma and renal oncocytoma are similar in appearance.
  • While it is well established that chromophobe renal cell carcinoma and renal oncocytoma have different patterns of genetic anomalies, little is known of the genetics of the eosinophilic variant of chromophobe renal cell carcinoma.
  • This study was undertaken to elucidate the genetic lesions of eosinophilic chromophobe renal cell carcinoma and to compare them with those found in classic chromophobe renal cell carcinoma and in renal oncocytoma.
  • A total of 29 renal neoplasms--nine eosinophilic chromophobe renal cell carcinomas, 10 classic chromophobe renal cell carcinomas, and 10 oncocytomas--were investigated by fluorescence in situ hybridization on 5 microm paraffin-embedded tissue sections with centromeric probes for chromosomes 1, 2, 6, 10, and 17.
  • Signals were counted in 100-200 neoplastic nuclei from each tumor.
  • Chromophobe renal cell carcinomas frequently showed loss of chromosomes 1 (70% of classic, 67% of eosinophilic), 2 (90% classic, 56% eosinophilic), 6 (80% classic, 56% eosinophilic), 10 (60% classic, 44% eosinophilic), and 17 (90% classic, 78% eosinophilic); Among the classic chromophobe renal cell carcinomas, only one had no loss of any of the chromosomes, while 50% had loss of all five chromosomes.
  • Among the eosinophilic chromophobe renal cell carcinomas, one of nine had no loss and 44% had loss of all five chromosomes.
  • One oncocytoma had loss of chromosome 1.
  • In conclusion, losses of chromosomes 1, 2, 6, 10, and 17 are frequent in both eosinophilic and classic chromophobe renal cell carcinomas.
  • Loss of chromosome 1 occurs occasionally in oncocytoma but losses of chromosomes 2, 6, 10, and 17 are not found in oncocytomas.
  • When the differential diagnostic problem is oncocytoma vs eosinophilic chromophobe renal cell carcinoma, detection of losses of chromosomes 2, 6, 10, or 17 effectively excludes the diagnosis of oncocytoma and supports the diagnosis of chromophobe renal cell carcinoma.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Renal Cell / pathology. Chromosome Aberrations. Kidney Neoplasms / pathology

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  • (PMID = 15467713.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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18. Hornsby CD, Cohen C, Amin MB, Picken MM, Lawson D, Yin-Goen Q, Young AN: Claudin-7 immunohistochemistry in renal tumors: a candidate marker for chromophobe renal cell carcinoma identified by gene expression profiling. Arch Pathol Lab Med; 2007 Oct;131(10):1541-6
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  • [Title] Claudin-7 immunohistochemistry in renal tumors: a candidate marker for chromophobe renal cell carcinoma identified by gene expression profiling.
  • CONTEXT: The differential diagnosis of eosinophilic renal tumors can be difficult by light microscopy.
  • In particular, chromophobe renal cell carcinoma (RCC) is difficult to distinguish from oncocytoma.
  • This differential diagnosis is important because chromophobe RCC is malignant, whereas oncocytoma is benign.
  • Immunohistochemistry is useful for distinguishing chromophobe RCC from other subtypes of renal carcinoma, but no expression marker reliably separates chromophobe RCC from oncocytoma.
  • OBJECTIVE: In a previous gene expression microarray analysis of renal tumor subtypes, we found the distal nephron markers claudin-7 and claudin-8 to be overexpressed in chromophobe RCC versus oncocytoma and other tumor subtypes.
  • CONCLUSIONS: Based on microarray and immunohistochemical data, we propose claudin-7 to be a candidate expression marker for distinguishing chromophobe RCC from other renal tumor subtypes, including the morphologically similar oncocytoma.
  • The clinical utility of claudin-7 should be validated in independent studies of renal tumors, possibly in combination with additional targets in a multiplex immunohistochemical panel.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Renal Cell / metabolism. Gene Expression. Gene Expression Profiling / methods. Kidney Neoplasms / metabolism. Membrane Proteins / metabolism
  • [MeSH-minor] Adenoma, Oxyphilic / diagnosis. Claudins. Diagnosis, Differential. Immunohistochemistry. RNA, Messenger / metabolism. RNA, Neoplasm / analysis

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  • (PMID = 17922590.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 1 U54 CA119338-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Validation Studies
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CLDN7 protein, human; 0 / Claudins; 0 / Membrane Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm
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19. Feriozzi S, Giannakakis K, Ranalli TV, Pofi E, Gomes V, Ancarani E: Renal oncocytoma associated with necrotizing glomerulonephritis. Ren Fail; 2006;28(2):181-3
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  • [Title] Renal oncocytoma associated with necrotizing glomerulonephritis.
  • A case of renal oncocytoma associated with focal segmental necrotizing glomerulonephritis is described.
  • The patient showed haematuria, mild proteinuria and arterial hypertension; the diagnosis was made after right nephrectomy performed because of the presence of a renal mass.
  • Our case is the first reported in which the removal of renal oncocytoma is not followed by the disappearance of renal symptoms, as currently reported in literature, suggesting that the two diseases are not always related.
  • [MeSH-major] Adenoma, Oxyphilic / complications. Glomerulosclerosis, Focal Segmental / complications. Kidney Neoplasms / complications


20. Adley BP, Gupta A, Lin F, Luan C, Teh BT, Yang XJ: Expression of kidney-specific cadherin in chromophobe renal cell carcinoma and renal oncocytoma. Am J Clin Pathol; 2006 Jul;126(1):79-85
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  • [Title] Expression of kidney-specific cadherin in chromophobe renal cell carcinoma and renal oncocytoma.
  • Kidney-specific cadherin (Ksp-cad) recently was proposed to differentiate chromophobe renal cell carcinoma (RCC) from oncocytoma based on a finding of Ksp-cad expression in 97% of chromophobe RCCs but only 3% of oncocytomas.
  • We attempted to evaluate Ksp-cad expression in renal tumors using expression microarrays and immunohistochemical analysis.
  • Ksp-cad messenger RNA (mRNA) levels were examined in 158 renal tumors, including 15 chromophobe RCCs and 15 oncocytomas.
  • Immunohistochemical analysis was performed on tissue microarrays containing 125 renal tumors, including 36 chromophobe RCCs and 41 oncocytomas.
  • Ksp-cad mRNA compared with normal kidney tissue was 89% in chromophobe RCC and 64% in oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / metabolism. Cadherins / metabolism. Carcinoma, Renal Cell / metabolism. Kidney Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Immunoenzyme Techniques. Oligonucleotide Array Sequence Analysis. RNA, Messenger / metabolism. Retrospective Studies


21. Saillant J, Fontana L, Biat I, Boudet G, Maublant C, Chamoux A: Report of three cases of renal oncocytoma in the same French chemical industrial factory. J Occup Environ Med; 2009 Oct;51(10):1113-5
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  • [Title] Report of three cases of renal oncocytoma in the same French chemical industrial factory.

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  • (PMID = 19820548.001).
  • [ISSN] 1536-5948
  • [Journal-full-title] Journal of occupational and environmental medicine
  • [ISO-abbreviation] J. Occup. Environ. Med.
  • [Language] ENG
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] WD06X94M2D / Vinyl Chloride
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22. Abrahams NA, Tamboli P: Oncocytic renal neoplasms: diagnostic considerations. Clin Lab Med; 2005 Jun;25(2):317-39, vi
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  • [Title] Oncocytic renal neoplasms: diagnostic considerations.
  • Advances in our understanding of renal neoplasia have resulted in recognition of numerous tumors that are composed predominantly of cells with abundant eosinophilic cytoplasm.
  • This article discusses the features of renal oncocytoma (including oncocytosis), chromophobe renal cell carcinoma (RCC), and clear cell RCC; explores the relationship between renal oncocytoma and chromophobe RCC; briefly discusses other tumors with abundant eosinophilic cytoplasm; and emphasizes the differential diagnosis of such tumors.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Eosinophils / pathology. Humans. Neoplastic Syndromes, Hereditary / pathology. Proteins / genetics. Proto-Oncogene Proteins. Tumor Suppressor Proteins

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  • (PMID = 15848739.001).
  • [ISSN] 0272-2712
  • [Journal-full-title] Clinics in laboratory medicine
  • [ISO-abbreviation] Clin. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / FLCN protein, human; 0 / Proteins; 0 / Proto-Oncogene Proteins; 0 / Tumor Suppressor Proteins
  • [Number-of-references] 98
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23. Adley BP, Papavero V, Sugimura J, Teh BT, Yang XJ: Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma. Anal Quant Cytol Histol; 2006 Aug;28(4):228-36
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  • [Title] Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma.
  • STUDY DESIGN: CK7 and parvalbumin mRNA expression levels in 23 oncocytomas and 32 chromophobe renal cell carcinomas (RCCs) were examined using gene expression microarrays.
  • CONCLUSION: Both mRNA and protein expression levels of CK7 appear significantly higher in chromophobe RCC compared to oncocytoma (p < 0.001).
  • Our study provides further evidence that CK7 and parvalbumin immunostains may be useful in differentiating oncocytoma from chromophobe RCC in problematic cases.
  • Negative or patchy staining (< 50% cells) for CK7 and/or parvalbumin strongly favors the diagnosis of oncocytoma.


24. Muñoz-Delgado E, Montenegro MF, Morote-García JC, Campoy FJ, Cabezas-Herrera J, Kovacs G, Vidal CJ: The expression of cholinesterases in human renal tumours varies according to their histological types. Chem Biol Interact; 2008 Sep 25;175(1-3):340-2
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  • [Title] The expression of cholinesterases in human renal tumours varies according to their histological types.
  • The change in the expression of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities in neoplastic colon and lung prompted us to study the possible effect of cancer on the expression of cholinesterases (ChEs) in kidney.
  • Samples of papillary renal cell carcinoma (pRCC), conventional RCC (cRCC), chromophobe RCC (chRCC) and renal oncocytoma (RON), beside adjacent non-cancerous tissues, were analyzed.
  • Abundant amphiphilic AChE dimers (G(2)(A)) and fewer monomers (G(1)(A)) were identified in healthy kidney as well as in all tumour classes.
  • RT-PCR showed similar amounts of AChE-H, AChE-T and BuChE mRNAs in healthy kidney.
  • The data support the idea that, as in lung tumours, in renal carcinomas expression of ChE mRNAs, biosynthesis of molecular components and level of enzyme activity change according to the specific kind of cell from which tumours arise.
  • [MeSH-major] Acetylcholinesterase / metabolism. Butyrylcholinesterase / metabolism. Kidney Neoplasms / enzymology

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  • (PMID = 18482720.001).
  • [ISSN] 0009-2797
  • [Journal-full-title] Chemico-biological interactions
  • [ISO-abbreviation] Chem. Biol. Interact.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] EC 3.1.1.- / Butyrylcholinesterase; EC 3.1.1.7 / Acetylcholinesterase
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25. Mogorovich A, Giannarini G, De Maria M, Manassero F, Selli C: Multifocal and bilateral renal oncocytoma: a case report and review of the literature. Arch Ital Urol Androl; 2007 Sep;79(3):130-4
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  • [Title] Multifocal and bilateral renal oncocytoma: a case report and review of the literature.
  • A 78-year-old man presenting with synchronous, multifocal and bilateral renal oncocytomas underwent a staged nephron-sparing surgery with removal of six lesions.
  • At 14-month follow-up the renal function was preserved and no recurrent disease was evident.

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  • (PMID = 18041365.001).
  • [ISSN] 1124-3562
  • [Journal-full-title] Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
  • [ISO-abbreviation] Arch Ital Urol Androl
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 42
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26. Mazal PR, Exner M, Haitel A, Krieger S, Thomson RB, Aronson PS, Susani M: Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma. Hum Pathol; 2005 Jan;36(1):22-8
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  • [Title] Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma.
  • Distinguishing renal oncocytoma from chromophobe and other renal carcinomas is essential, considering their differing biological potentials.
  • Although renal oncocytoma is considered a benign tumor, chromophobe renal cell carcinoma has potentially malignant biological behavior.
  • We report a novel immunohistochemical approach based on the expression of a recently described kidney-specific cadherin (Ksp-cadherin) for the differential diagnosis of these 2 tumors.
  • We compared Ksp-cadherin expression in 212 renal tumors, including 102 clear cell renal carcinomas, 46 papillary renal cell carcinomas, 30 chromophobe carcinomas, 3 collecting duct carcinomas, and 31 oncocytomas.
  • In addition, we examined the expression of epithelial membrane antigen, vimentin, CK7, and Hale's colloidal iron staining.
  • We found that chromophobe renal cell carcinomas consistently (96.7% of cases) demonstrated a distinctive membrane pattern of Ksp-cadherin expression, whereas renal oncocytomas (3.2%), clear cell renal cell carcinomas (0%), papillary renal cell carcinomas (2.2%), and collecting duct carcinomas (0%) usually did not express Ksp-cadherin.
  • CK7 expression was found in 90.0%, 6.5%, 7.8%, 76.1%, and 33.3% of these tumor cases, respectively.
  • Whereas CK7 was detected in different types of renal cell carcinomas, Ksp-cadherin was expressed almost exclusively in chromophobe renal cell carcinomas.
  • Immunohistochemical analysis of Ksp-cadherin offers a fast, reliable approach for the distinguishing between renal oncocytoma and chromophobe renal cell carcinoma that is applicable for routine pathology laboratory studies without the need for time-consuming and costly ancillary studies.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma, Papillary / metabolism. Adenoma, Oxyphilic / metabolism. Biomarkers, Tumor / analysis. Cadherins / biosynthesis. Kidney Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma, Clear Cell / metabolism. Adenocarcinoma, Clear Cell / pathology. Adolescent. Adult. Aged. Aged, 80 and over. Blotting, Western. Carcinoma, Renal Cell / metabolism. Carcinoma, Renal Cell / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Middle Aged


27. Mai KT, Teo I, Belanger EC, Robertson SJ, Marginean EC, Islam S: Progesterone receptor reactivity in renal oncocytoma and chromophobe renal cell carcinoma. Histopathology; 2008 Feb;52(3):277-82
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  • [Title] Progesterone receptor reactivity in renal oncocytoma and chromophobe renal cell carcinoma.
  • AIMS: To investigate the reactivity for oestrogen and progesterone receptors (ER and PR) in renal oncocytoma (RO) and chromophobe renal cell carcinoma (CHRCC).
  • MATERIALS AND METHODS: Thirty-eight RO, 25 CHRCC, 20 papillary RCC with oncocytic cytoplasm and 10 clear cell RCC with dominant eosinophilic cytoplasm were submitted for immunohistochemistry for ER, PR, CD117 and RCC.
  • CONCLUSIONS: PR can be used in combination with CD117 and RCC in the differential diagnosis of RO and eosinophilic variant of CHRCC with other RCC with oncocytic or eosinophilic cytoplasm.
  • [MeSH-major] Adenoma, Oxyphilic / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Renal Cell / metabolism. Kidney Neoplasms / metabolism. Receptors, Progesterone / metabolism
  • [MeSH-minor] Cell Nucleus / metabolism. Cell Nucleus / pathology. Diagnosis, Differential. Female. Humans. Immunoenzyme Techniques. Male. Proto-Oncogene Proteins c-kit / metabolism. Receptors, Estrogen / metabolism


28. Ploussard G, Droupy S, Ferlicot S, Ples R, Rocher L, Richard S, Benoit G: [Renal oncocytosis: case report]. Prog Urol; 2009 Feb;19(2):142-4
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  • [Title] [Renal oncocytosis: case report].
  • Renal oncocytoma represent 5% of kidney tumors.
  • Oncocytoma is a benign tumor, usually asymptomatic and fortuitous discovery.
  • Surgery is indicated when oncocytoma becomes symptomatic, large or grows quickly.
  • We report here the case of a patient suffering from renal oncocytosis responsible for a diffuse renal involvement by numerous oncocytic nodules.
  • [MeSH-major] Kidney Diseases / pathology. Oxyphil Cells

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  • (PMID = 19168021.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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29. Skolarus TA, Serrano MF, Grubb RL 3rd, Katz MD, Bullock TL, Gao F, Humphrey PA, Kibel AS: Effect of reclassification on the incidence of benign and malignant renal tumors. J Urol; 2010 Feb;183(2):455-8
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  • [Title] Effect of reclassification on the incidence of benign and malignant renal tumors.
  • PURPOSE: The incidence of benign renal tumors has increased in recent years.
  • To further investigate the impact of histological reclassification we reexamined all excised renal masses using the 2004 WHO criteria and compared this histological classification to the prior criteria.
  • The percentages of benign lesions per year according to the prior histological and current WHO 2004 histological criteria were compared.
  • RESULTS: Of the 1,101 renal masses 132 (12.0%) and 165 (15.0%) were classified as benign using prior and current WHO criteria, respectively.
  • On average the WHO criteria diagnosed more benign tumors per year than the prior criteria (p = 0.004).
  • Linear regression demonstrated a similar, persistent increase in benign diagnoses per year of 0.69% (WHO) and 1.22% (prior) during the 14-year period (p = 0.33).
  • All masses reclassified as benign were oncocytoma (33).
  • CONCLUSIONS: Implementation of the 2004 WHO criteria is contributing to the increase in diagnosis of benign renal lesions, specifically oncocytoma.
  • Other factors, which remain to be delineated, are also contributing to the increase in the diagnosis of benign renal lesions.
  • [MeSH-major] Kidney Neoplasms / classification. Kidney Neoplasms / epidemiology

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  • [Copyright] Copyright 2010 American Urological Association. Published by Elsevier Inc. All rights reserved.
  • [CommentIn] J Urol. 2010 Sep;184(3):1222 [20650500.001]
  • [CommentIn] J Urol. 2010 Feb;183(2):459; discussion 459 [20006881.001]
  • [CommentIn] J Urol. 2010 Aug;184(2):804 [20639058.001]
  • (PMID = 20006852.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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30. Heckmann M, Heinrich M, Humke U, Bautz W, Uder M: [Differential diagnosis of focal lesions of the kidney in CT and MRT]. Rontgenpraxis; 2008;56(6):219-40
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  • [Title] [Differential diagnosis of focal lesions of the kidney in CT and MRT].
  • The great majority of renal masses are found incidentally as a result of the use of ultrasonography, computed tomography (CT) and magnetic resonance imaging (MRI).
  • If ultrasonography is not diagnostic CT or MRI should be initiated to differentiate lesions of the kidney that need surgical intervention from those that do not and from those that need follow-up examinations.
  • Cystic renal masses are characterized by using the Bosniak classification, including category IIF.
  • In solid Lesions of the kidney first non-surgical lesions as well as lymphoma, renal infarction and nephritis should be excluded.
  • Identifying fatty components in renal lesions is very important because in angiomyolipoma they are almost always present.
  • CT and MRI are exellent for tumor detection.
  • Careful evaluation of imaging finding combined with the patient's history should assist the radiologist in making the proper diagnosis or recommending the appropriate treatment in most cases.
  • This article provides a review about renal masses, the imaging methods for their evaluation and their characteristic features at CT and MR imaging.
  • Different lesions are demonstrated like xantogranulomatous pyelonephritis, acute pyelonephritis, renal infarction, lymphoma, angiomyolipoma, renal oncocytoma, cystic lesion and polycystic disease the kidney, echinococcosis, renal cystadenoma, metastases, renal cell carcinoma (RCC), and multiple bilateral RCC in patients with Hippel-Lindau-Syndrome.
  • This article should help to differentiate complex cystic lesions of the kidney by using the Bosniak-classification, especially Bosniak Category IIF.
  • [MeSH-major] Kidney Diseases / diagnosis. Magnetic Resonance Imaging / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Contrast Media. Diagnosis, Differential. Female. Follow-Up Studies. Gadolinium DTPA. Humans. Kidney Diseases, Cystic / classification. Kidney Diseases, Cystic / diagnosis. Kidney Diseases, Cystic / radiography. Kidney Neoplasms / diagnosis. Kidney Neoplasms / radiography. Lymphoma / diagnosis. Lymphoma / radiography. Male. Polycystic Kidney Diseases / diagnosis. Polycystic Kidney Diseases / radiography. Pyelonephritis / diagnosis. Pyelonephritis / radiography. von Hippel-Lindau Disease / diagnosis. von Hippel-Lindau Disease / radiography

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  • (PMID = 19294868.001).
  • [ISSN] 0035-7820
  • [Journal-full-title] Röntgenpraxis; Zeitschrift für radiologische Technik
  • [ISO-abbreviation] Rontgenpraxis
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
  • [Number-of-references] 24
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31. Van der Kwast T, Perez-Ordoñez B: Renal oncocytoma, yet another tumour that does not fit in the dualistic benign/malignant paradigm? J Clin Pathol; 2007 Jun;60(6):585-6
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  • [Title] Renal oncocytoma, yet another tumour that does not fit in the dualistic benign/malignant paradigm?
  • [MeSH-major] Adenoma, Oxyphilic / secondary. Kidney Neoplasms / pathology
  • [MeSH-minor] Humans. Neoplasm Invasiveness. Prognosis

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  • (PMID = 17557864.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Comment; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 16
  • [Other-IDs] NLM/ PMC1955085
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32. Westermann DH, Rüdiger T, Lohe B, Frohneberg D: [Birt-Hogg-Dubé syndrome : bilateral oncocytic kidney tumors in a patient]. Urologe A; 2010 Dec;49(12):1527-31
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  • [Title] [Birt-Hogg-Dubé syndrome : bilateral oncocytic kidney tumors in a patient].
  • [Transliterated title] Birt-Hogg-Dubé-Syndrom : Bilateraler onkozytischer Hybridtumor der Niere.
  • We report on a rare case of bilateral oncocytic kidney tumors in a patient with Birt-Hogg-Dubé syndrome (BHD).
  • BHD is an autosomal inherited cancer syndrome associated with multiple kidney tumors, benign cutaneous tumors, and pulmonary cysts with spontaneous pneumothorax.
  • Close follow-up is mandatory because recurrence in previously operated kidneys and metastatic tumor progression can occur.
  • [MeSH-major] Birt-Hogg-Dube Syndrome / diagnosis. Birt-Hogg-Dube Syndrome / surgery. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / surgery
  • [MeSH-minor] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / surgery. Humans. Kidney Neoplasms / diagnosis. Kidney Neoplasms / surgery. Male. Middle Aged. Syndrome. Treatment Outcome

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  • (PMID = 20949256.001).
  • [ISSN] 1433-0563
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] Oncocytoma, renal
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33. D'Antonio A, Caleo A, Caleo O, Addesso M, Boscaino A: Hepatocellular carcinoma metastatic to the kidney mimicking renal oncocytoma. Hepatobiliary Pancreat Dis Int; 2010 Oct;9(5):550-2
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  • [Title] Hepatocellular carcinoma metastatic to the kidney mimicking renal oncocytoma.
  • BACKGROUND: Renal metastases of hepatocellular carcinoma (HCC) are very rare.
  • METHODS: We describe the clinico-pathological features of a rare case of HCC metastatic to the kidney in which the renal mass was the clinical debut of disease.
  • The patient was a 54-year-old woman previously submitted to orthotopic liver transplantation, who underwent left nephrectomy for a renal mass.
  • RESULTS: Histologically, the tumor was composed mainly of epithelioid cells with homogeneous acidophilic cytoplasm resembling oncocytoma or primary renal carcinoma with oncocytic features.
  • A correct diagnosis was made on the basis of positive immunostaining for hepatocyte paraffin 1.
  • CONCLUSIONS: Metastasis to the kidney is a rare complication that should be considered whenever a renal mass is present in patients with HCC.
  • Since HCC may histologically resemble primary renal tumors such as oncocytoma, pathologists must be aware of this possibility above all in patients referred for liver transplantation and treated with immunosuppressant drugs.
  • Immunohistochemistry is particularly helpful to establish a precise diagnosis in cases of doubt.
  • [MeSH-major] Carcinoma, Hepatocellular / diagnosis. Carcinoma, Hepatocellular / pathology. Kidney Neoplasms / diagnosis. Kidney Neoplasms / secondary. Liver Neoplasms / diagnosis. Liver Neoplasms / pathology
  • [MeSH-minor] Adenoma, Oxyphilic / diagnosis. Diagnosis, Differential. Fatal Outcome. Female. Humans. Liver Transplantation / pathology. Middle Aged. Neoplasm Metastasis

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  • (PMID = 20943467.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] Oncocytoma, renal
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34. Osunkoya AO, Cohen C, Lawson D, Picken MM, Amin MB, Young AN: Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. Hum Pathol; 2009 Feb;40(2):206-10
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  • [Title] Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.
  • In a recent oligonucleotide microarray study, we identified claudin-7 and claudin-8 as candidate markers to distinguish chromophobe renal cell carcinoma from other renal tumors, including oncocytoma.
  • Distinction of these lesions can be difficult by light microscopy but is clinically important because chromophobe renal cell carcinoma has malignant biological potential, whereas renal oncocytoma is benign.
  • Claudin-7 and claudin-8 expression was studied by immunohistochemistry in 11 chromophobe renal cell carcinomas and 17 oncocytomas using formalin-fixed paraffin-embedded tissue sections of tumor with adjacent nonneoplastic kidney.
  • Specificity was verified by negative control reactions without primary antibody and appropriate membranous staining patterns in positive control tissues (colon carcinoma and adjacent nonneoplastic kidney).
  • Claudin-7 protein was expressed in a membranous pattern in 10 of 11 chromophobe renal cell carcinomas and 4 of 17 oncocytomas (P < .01).
  • Claudin-8 was expressed in multiple patterns: In oncocytoma, 11 of 17 cases showed cytoplasmic, 4 of 17 membranous, and 2 of 17 negative reactions.
  • In chromophobe renal cell carcinoma, 0 of 11 cases showed cytoplasmic, 3 of 11 membranous, and 8 of 11 negative reactions (P < .01).
  • The immunohistochemical pattern of membranous claudin-7 and negative claudin-8 was seen in 7 of 11 chromophobe renal cell carcinomas and 1 of 17 oncocytomas (63% sensitivity, 84% specificity, 88% positive predictive value for chromophobe renal cell carcinoma).
  • Negative claudin-7 and cytoplasmic claudin-8 were observed in 10 of 17 oncocytomas and 0 of 11 chromophobe renal cell carcinomas (59% sensitivity, 100% specificity and positive predictive value for oncocytoma).
  • The distal nephron proteins claudin-7 and claudin-8 have potential use as immunohistochemical biomarkers in the differential diagnosis of chromophobe renal cell carcinoma and oncocytoma.
  • Expression of claudin-7 and claudin-8 may reflect the relationship of chromophobe renal cell carcinoma and oncocytoma to intercalated cells of the cortical collecting duct.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Membrane Proteins / biosynthesis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Claudins. Diagnosis, Differential. Humans. Immunohistochemistry. Sensitivity and Specificity


35. Kim SS, Choi YD, Jin XM, Cho YM, Jang JJ, Juhng SW, Choi C: Immunohistochemical stain for cytokeratin 7, S100A1 and claudin 8 is valuable in differential diagnosis of chromophobe renal cell carcinoma from renal oncocytoma. Histopathology; 2009 Apr;54(5):633-5
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  • [Title] Immunohistochemical stain for cytokeratin 7, S100A1 and claudin 8 is valuable in differential diagnosis of chromophobe renal cell carcinoma from renal oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Keratin-7 / metabolism. Kidney Neoplasms / diagnosis. Membrane Proteins / metabolism. S100 Proteins / metabolism
  • [MeSH-minor] Biomarkers, Tumor / analysis. Claudins. Diagnosis, Differential. Humans. Immunohistochemistry / methods. Staining and Labeling / methods


36. Nagashima Y, Mitsuya T, Shioi KI, Noguchi S, Kishida T, Hamano A, Ohgo Y, Tsuura Y, Ogawa T, Aoki I, Yao M: Renal oncocytosis. Pathol Int; 2005 Apr;55(4):210-5
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  • [Title] Renal oncocytosis.
  • Renal oncocytosis is a rare disorder in which numerous oncocytic nodules develop in the kidney.
  • Nineteen years previously she had developed a tumorous lesion in the right kidney, which had been diagnosed as oncocytoma with laparotomic biopsy.
  • Recently the kidney was removed because of enlargement of the tumor.
  • The renal parenchyma was entirely replaced with numerous brownish nodules.
  • Histologically, the nodules were composed of nests of uniform oncocytic cells.
  • Ultrastructurally, the oncocytic cells contained numerous mitochondria.
  • Based on these findings, the lesion was diagnosed as renal oncocytosis.
  • It was not possible to determine whether the larger nodules should be diagnosed as oncocytoma or a part of oncocytosis.
  • Despite the rare occurrence pathologists and urologists should be aware of renal oncocytosis, as a precursor lesion of renal oncocytoma and chromophobe renal cell carcinoma.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Kidney / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Cadherins / analysis. DNA Mutational Analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratin-7. Keratins / analysis. Microscopy, Electron. Middle Aged. Mucin-1 / analysis. Neoplasms, Multiple Primary / pathology. Proteins / genetics. Proto-Oncogene Proteins. Tumor Suppressor Proteins. Vimentin / analysis

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  • (PMID = 15826248.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Cadherins; 0 / FLCN protein, human; 0 / KRT7 protein, human; 0 / Keratin-7; 0 / Mucin-1; 0 / Proteins; 0 / Proto-Oncogene Proteins; 0 / Tumor Suppressor Proteins; 0 / Vimentin; 68238-35-7 / Keratins
  • [Number-of-references] 21
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37. Pahernik S, Roos F, Hampel C, Gillitzer R, Melchior SW, Thüroff JW: Nephron sparing surgery for renal cell carcinoma with normal contralateral kidney: 25 years of experience. J Urol; 2006 Jun;175(6):2027-31
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  • [Title] Nephron sparing surgery for renal cell carcinoma with normal contralateral kidney: 25 years of experience.
  • PURPOSE: We report the long-term results of our consecutive series of 504 patients who underwent NSS for cancer suspicious, solid renal tumors in the presence of a normal opposite kidney at our institution since 1979.
  • MATERIALS AND METHODS: A total of 715 patients underwent NSS since 1969, including 504 for an elective indication, that is with a normal opposite kidney.
  • Of these patients 381 (75.6%) had RCC, 123 (24.4%) had cancer suspicious benign lesions, including 53 (10.5%) with oncocytoma, 33 (6.5%) with angiomyo(lipo)ma, 23 (4.6%) with a complicated cyst and 13 (2.8%) with other benign lesions.
  • Mean tumor diameter was 3.0 cm (range 0.5 to 11.0).
  • The oncological outcome was studied, including pathological features associated with tumor progression.
  • CONCLUSIONS: The long-term results of our series support the concept of organ sparing surgery for RCC in the presence of a normal opposite kidney with excellent long-term survival and a low tumor recurrence rate.
  • [MeSH-major] Carcinoma, Renal Cell / surgery. Kidney Neoplasms / surgery. Nephrectomy / methods

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  • (PMID = 16697793.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Choi YD, Kim KS, Ryu S, Park Y, Cho NH, Rha SH, Jang JJ, Ro JY, Juhng SW, Choi C: Claudin-7 is highly expressed in chromophobe renal cell carcinoma and renal oncocytoma. J Korean Med Sci; 2007 Apr;22(2):305-10
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  • [Title] Claudin-7 is highly expressed in chromophobe renal cell carcinoma and renal oncocytoma.
  • We tested the possibility that expression of claudin-7 could be used as a marker of renal tumors originating from the distal nephron.
  • We examined the immunohistochemical expression of claudin-7 and parvalbumin in 239 renal tumors, including 179 clear cell renal cell carcinoma (RCC)s, 29 papillary RCCs, 20 chromophobe RCCs, and 11 renal oncocytomas.
  • Claudin-7 and parvalbumin immunostains were positive in 3.4%, 7.8% of clear cell RCCs, 34.5%, 31.0% of papillary RCCs, 95.0%, 80.0% of chromophobe RCCs, and 72.7%, 81.8% of renal oncocytomas, respectively.
  • The expression pattern of claudin-7 was mostly diffuse in chromophobe RCC and was either focal or diffuse in oncocytoma.
  • Claudin-7 can be used as a useful diagnostic marker in diagnosing chromophobe RCC and oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / metabolism. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / metabolism. Kidney Neoplasms / diagnosis. Kidney Neoplasms / metabolism. Membrane Proteins / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Claudins. Humans. Neoplasm Proteins / metabolism. Nephrons / metabolism. Reproducibility of Results. Sensitivity and Specificity. Tissue Distribution. Tumor Cells, Cultured

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  • (PMID = 17449941.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CLDN7 protein, human; 0 / Claudins; 0 / Membrane Proteins; 0 / Neoplasm Proteins
  • [Other-IDs] NLM/ PMC2693599
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39. Wang HY, Mills SE: KIT and RCC are useful in distinguishing chromophobe renal cell carcinoma from the granular variant of clear cell renal cell carcinoma. Am J Surg Pathol; 2005 May;29(5):640-6
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  • [Title] KIT and RCC are useful in distinguishing chromophobe renal cell carcinoma from the granular variant of clear cell renal cell carcinoma.
  • The distinction between chromophobe renal cell carcinoma, the granular cell variant of clear cell renal cell carcinoma, and renal oncocytoma is a common diagnostic dilemma.
  • The usefulness of KIT, CD10, RCC, and RON in the differential diagnosis of these renal epithelial tumors was investigated.
  • KIT was 100% positive in chromophobe renal cell carcinoma (11 of 11) and renal oncocytoma (12 of 12).
  • The KIT staining pattern was identical in both tumor types, with cytoplasmic membrane attenuation, and fine granular cytoplasmic staining.
  • In contrast, KIT was absent in all granular cell variants of clear cell renal cell carcinoma (0 of 6).
  • RCC was observed in more than 80% of the granular cell variant of clear cell renal cell carcinoma (5 of 6) but was negative in all chromophobe renal cell carcinomas (0 of 11) and renal oncocytomas (0 of 12).
  • CD10 was expressed in 100% of the granular cell variant of clear cell renal cell carcinoma (6 of 6), 72% of chromophobe renal cell carcinomas (8 of 11), and 58% of renal oncocytomas (7 of 12).
  • RON was 100% positive in the chromophobe renal cell carcinomas (11 of 11) and renal oncocytomas (12 of 12) but only 50% positive in the granular cell variant of clear cell renal cell carcinoma (3 of 6).
  • Colloidal iron was diffusely and strongly positive in more than 80% of the chromophobe renal cell carcinomas (9 of 11), focally and weakly positive in 41% of the renal oncocytomas (5 of 12) but negative in all granular cell variant of clear cell renal cell carcinoma (0 of 6).
  • 1) KIT is a very sensitive marker for both chromophobe renal cell carcinoma and renal oncocytoma;.
  • 2) immunohistochemistry using antibodies to KIT combined with RCC was sufficient to discriminate between chromophobe renal cell carcinoma and the granular cell variant of clear cell renal cell carcinoma; and 3) neither RON, nor KIT, nor a combination of this panel can be used to distinguish chromophobe renal cell carcinoma from renal oncocytoma.
  • Colloidal iron staining aided in this distinction for the majority of the chromophobe renal cell carcinomas (more than 80% positive) and renal oncocytomas (close to 60% negative).
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Mitogen-Activated Protein Kinases. Proto-Oncogene Proteins c-kit
  • [MeSH-minor] Antigens, Neoplasm. Biomarkers, Tumor. Cytoplasmic Granules / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Neprilysin. Receptor Protein-Tyrosine Kinases

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  • (PMID = 15832088.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; EC 2.7.1.- / RON protein; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.11.22 / MOK protein, human; EC 2.7.11.24 / Mitogen-Activated Protein Kinases; EC 3.4.24.11 / Neprilysin
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40. Picken MM, Chyna B, Flanigan RC, Lee JM: Analysis of chromosome 1p abnormalities in renal oncocytomas by loss of heterozygosity studies: correlation with conventional cytogenetics and fluorescence in situ hybridization. Am J Clin Pathol; 2008 Mar;129(3):377-82
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  • [Title] Analysis of chromosome 1p abnormalities in renal oncocytomas by loss of heterozygosity studies: correlation with conventional cytogenetics and fluorescence in situ hybridization.
  • We previously showed by cytogenetics and fluorescence in situ hybridization (FISH) that the most common chromosomal abnormality in renal oncocytomas is loss of chromosome 1 or 1p.
  • LOH was detected in at least 1 locus in 12 (86%) of 14 renal oncocytomas studied, with other loci being noninformative or not interpretable (1 case).
  • These results provide further evidence to support widespread abnormalities in chromosome 1p in renal oncocytoma.
  • Determining whether such abnormalities are unique to renal oncocytomas or are also present in other tumors requires further studies.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Chromosomes, Human, Pair 1 / genetics. Kidney Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chromosome Aberrations. DNA, Neoplasm / analysis. Female. Humans. In Situ Hybridization, Fluorescence. Loss of Heterozygosity. Male. Microsatellite Repeats. Middle Aged. Polymerase Chain Reaction

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  • (PMID = 18285259.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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41. Yang XJ, Sugimura J, Schafernak KT, Tretiakova MS, Han M, Vogelzang NJ, Furge K, Teh BT: Classification of renal neoplasms based on molecular signatures. J Urol; 2006 Jun;175(6):2302-6
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  • [Title] Classification of renal neoplasms based on molecular signatures.
  • PURPOSE: Gene expression microarray studies have demonstrated distinct molecular signatures for different types of renal neoplasms based on overall gene expression patterns.
  • However, in most of these studies the investigators used renal tumors with defined histology.
  • We analyzed a test set of renal tumors in double-blind fashion using recently established molecular profiles of renal tumors as benchmarks.
  • Analysis was clustered with our previously established molecular profiles of 91 histologically defined kidney neoplasms and comparative genomic microarray analysis while blinded to tumor histology and clinical information.
  • RESULTS: With molecular analysis 9, 4, 2 and 1 tumors were classified as clear cell, papillary RCC, chromophobe RCC, and renal oncocytoma, respectively.
  • One of the 2 tumors with a discrepancy between molecular and pathological diagnoses was composed of oncocytoma and high grade clear cell RCC, and the other was chromophobe RCC that histologically mimicked papillary RCC.
  • CONCLUSIONS: We report the feasibility of the molecular diagnosis and classification of unknown renal neoplasms.
  • Molecular diagnosis appears to be reliable and comparable to the standard of urological pathology.
  • This molecular method may be a potentially useful test for establishing an accurate diagnosis that can impact clinical management.
  • [MeSH-major] Carcinoma, Renal Cell / classification. Carcinoma, Renal Cell / genetics. Kidney Neoplasms / classification. Kidney Neoplasms / genetics. Oligonucleotide Array Sequence Analysis

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  • (PMID = 16697863.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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42. Delongchamps NB, Vieillefond A, Peyromaure M, Saighi D, Conquy S, Debré B, Zerbib M: [Hybrid renal tumors: a report of two patients]. Prog Urol; 2010 Dec;20(13):1223-6
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  • [Title] [Hybrid renal tumors: a report of two patients].
  • [Transliterated title] Tumeurs rénales hybrides: à propos de deux patients.
  • PURPOSE: Renal hybrid tumors (HT) are characterized by the association of both oncocytes- and chromophobe-cells within the same tumor.
  • RESULTS: Two patients were diagnosed with multiple but small tumors of the kidney, and were treated with partial nephrectomy.
  • Pathological analysis of these tumors showed oncocytoma-like and chromophobe-like cells intermixed in the same stroma.
  • CONCLUSIONS: HT may constitute a spectrum of tumors between renal oncocytoma and chromophobe renal cell carcinoma.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Angiomyolipoma / pathology. Kidney Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 21130404.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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43. Esposito M, Varca V, Simonato A, Toncini C, Carmignani G, Derchi L: [Coexistence of different histotypes of renal carcinoma:our experience and literature review]. Urologia; 2009 Apr-Jun;76(2):130-2
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  • [Title] [Coexistence of different histotypes of renal carcinoma:our experience and literature review].
  • The coexistence of multiple, synchronous primary tumors of different histology within the same kidney is a rare condition.
  • We report herein a series of five patients with two tumors of different histology involving synchronously the same kidney.
  • We reviewed the pathology reports of a series of 381 patients who underwent surgery for primary renal tumors at our institution from 2000 to 2007.
  • RESULTS. Five out of 381 patients (1.37%) had coexistence of two primary tumors of different histology within the same kidney.
  • CONCLUSIONS. The coexistence of multiple and synchronous primary tumors of different histology within the same kidney has been only rarely described.
  • To the best of our knowledge, in literature there are only case reports with the exception of a case of renal oncocytoma with evolving papillary RCC.

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  • (PMID = 21086315.001).
  • [ISSN] 1724-6075
  • [Journal-full-title] Urologia
  • [ISO-abbreviation] Urologia
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] United States
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44. Rosenkrantz AB, Hindman N, Fitzgerald EF, Niver BE, Melamed J, Babb JS: MRI features of renal oncocytoma and chromophobe renal cell carcinoma. AJR Am J Roentgenol; 2010 Dec;195(6):W421-7
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  • [Title] MRI features of renal oncocytoma and chromophobe renal cell carcinoma.
  • OBJECTIVE: The purpose of this study was to retrospectively describe the MRI features of the pathologically related entities renal oncocytoma and chromophobe renal cell carcinoma (RCC).
  • MATERIALS AND METHODS: Twenty-eight cases of histologically proven renal oncocytoma and 15 of chromophobe RCC evaluated with preoperative MRI from January 2003 through June 2009 at our institution were independently reviewed for an array of MRI features by two radiologists blinded to the final histopathologic diagnosis.
  • These features were tabulated and compared between chromophobe RCC and renal oncocytoma by use of the Mann-Whitney test and binary logistic regression.
  • RESULTS: Renal oncocytoma and chromophobe RCC showed no significant difference in size or any of 16 qualitative imaging features (p = 0.0842-1.0, reader 1; p = 0.0611-1.0, reader 2).
  • Microscopic fat, hemorrhage, cysts, infiltrative margins, perinephric fat invasion, renal vein invasion, enhancement homogeneity, and hypervascularity were each observed in less than 20% of cases by both readers.
  • A central scar and segmental enhancement inversion (a recently described finding in which early contrast-enhanced images show relatively more enhanced and less enhanced intralesional components with inversion of their relative enhancement on later images) were observed by both readers in at least 10% of cases of both renal oncocytoma and of chromophobe RCC with no significant difference between the two entities (p = 0.2092-0.2960).
  • CONCLUSION: We have presented the largest series to date of the MRI features of both renal oncocytoma and chromophobe RCC.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Magnetic Resonance Imaging / methods


45. Yen TH, Chen Y, Lin JL, Ng KF: Renal oncocytoma in Taiwan. Ren Fail; 2006;28(2):141-7
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  • [Title] Renal oncocytoma in Taiwan.
  • BACKGROUND: Renal oncocytoma has been repeatedly reported in Western countries, but only a few cases have been reported in Eastern countries.
  • This study aims to review the clinical course of renal oncocytoma in an Eastern country such as Taiwan.
  • MATERIALS AND METHODS: Sixteen cases of renal oncocytoma seen between 1987 and 2002 at Chang Gung Memorial Hospital, Taipei, Taiwan, were studied.
  • RESULTS: Preoperatively, all patients were diagnosed to have renal cell carcinoma, following various radiologic studies.
  • Perioperatively, frozen sections of three patients indicated renal oncocytoma in two and renal cell carcinoma in one.
  • Renal oncocytoma has marked similarities to renal cell carcinoma, according to various radiologic, cytologic, and pathological investigations, so an accurate diagnosis is difficult to achieve, either preoperatively or perioperatively.
  • Notably, all patients survived with no evidence of tumor recurrence.
  • CONCLUSIONS: The experience in Taiwan is generally that renal oncocytoma behaves benignly, as reported in other areas.
  • The excellent prognosis associated with this tumor appears to indicate that partial nephrectomy may suffice for removing the tumor, while sparing other unaffected renal parenchyma.
  • [MeSH-major] Adenoma, Oxyphilic. Kidney Neoplasms
  • [MeSH-minor] Aged. Carcinoma, Renal Cell / diagnosis. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Nephrectomy. Taiwan

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  • (PMID = 16538972.001).
  • [ISSN] 0886-022X
  • [Journal-full-title] Renal failure
  • [ISO-abbreviation] Ren Fail
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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46. Shomori K, Nagashima Y, Kuroda N, Honjo A, Tsukamoto Y, Tokuyasu N, Maeta N, Matsuura K, Hijiya N, Yano S, Yokoyama S, Ito H, Moriyama M: ARPP protein is selectively expressed in renal oncocytoma, but rarely in renal cell carcinomas. Mod Pathol; 2007 Feb;20(2):199-207
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  • [Title] ARPP protein is selectively expressed in renal oncocytoma, but rarely in renal cell carcinomas.
  • In the present study, we generated the anti-ARPP monoclonal antibody, YAS11, immunoreactive with the N-terminal region (amino-acids residues 1-145) of the ARPP protein.
  • Further, we immunohistochemically analyzed 100 renal tumors including 14 oncocytomas, and 86 renal cell carcinomas (RCCs).
  • Interestingly, ARPP was not detected in any of 11 chromophobe RCCs, suggesting that ARPP may be useful for differential diagnosis between oncocytoma and chromophobe RCC.
  • Furthermore, we found that ARPP was selectively expressed in part of the distal renal tubule in normal kidney.
  • Immunoelectron microscopy with anti-ARPP antibody revealed that ARPP was localized in mitochondria and nuclei in both the normal distal renal tubule and oncocytoma, suggesting that oncocytoma may be derived from the distal nephron, and probably from part of the distal renal tubule.
  • [MeSH-major] Adenoma, Oxyphilic / metabolism. Carcinoma, Renal Cell / metabolism. Kidney Neoplasms / metabolism. Muscle Proteins / metabolism. Nuclear Proteins / metabolism. Repressor Proteins / metabolism
  • [MeSH-minor] Antibodies, Monoclonal / biosynthesis. Antibodies, Monoclonal / immunology. Biomarkers, Tumor / metabolism. Blotting, Western. Cell Nucleus / metabolism. Cell Nucleus / ultrastructure. Diagnosis, Differential. Fluorescent Antibody Technique, Indirect. HeLa Cells. Humans. Immunoenzyme Techniques. Kidney Tubules, Distal / metabolism. Kidney Tubules, Distal / ultrastructure. Microscopy, Immunoelectron. Mitochondria / metabolism. Mitochondria / ultrastructure. Transfection

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  • (PMID = 17206105.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ANKRD2 protein, human; 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / Muscle Proteins; 0 / Nuclear Proteins; 0 / Repressor Proteins
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47. Morelli L, Pusiol T, Piscioli I, Larosa M, Pozzoli GL, Monica B: Concurrent occurrence of three primary neoplasms with different hystotype in the same kidney, associated with an adenoma of the omolateral adrenal gland: first case report. Int J Urol; 2006 Sep;13(9):1236-9
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  • [Title] Concurrent occurrence of three primary neoplasms with different hystotype in the same kidney, associated with an adenoma of the omolateral adrenal gland: first case report.
  • We present an unusual case of concurrent occurrence of three synchronous primary tumors in the same kidney (oncocytoma, chromophobe renal cell carcinoma, angiomyolipoma) associated to an adenoma of the omolateral adrenal gland in a patient with no evident clinical symptoms.
  • The immunohistochemistry showed a positivity for KIT in oncocytoma and chromophobe cell carcinoma, and a weak positivity in the angiomyolipoma, only in the cells positive for HMB-45.
  • [MeSH-major] Adenoma / pathology. Adenoma, Oxyphilic / pathology. Adrenal Gland Neoplasms / pathology. Angiomyolipoma / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 16984560.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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48. Muscarella LA, Barbano R, Augello B, Formica V, Micale L, Zelante L, D'Agruma L, Merla G: An 11-bp duplication in the promoter region of the VHL gene in a patient with cerebellar hemangioblastoma and renal oncocytoma. J Hum Genet; 2007;52(6):485-91
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  • [Title] An 11-bp duplication in the promoter region of the VHL gene in a patient with cerebellar hemangioblastoma and renal oncocytoma.
  • Central nervous system hemangioblastomas are benign vascular tumours that may present sporadically or as manifestation of the von Hippel-Lindau (VHL) disease.
  • VHL Syndrome is a rare autosomal dominant disorder characterized, besides hemangioblastomas, by susceptibility to multifocal and bilateral renal cell carcinoma and cysts, retinal angiomas, pheochromocytoma, epididymis cystoadenoma, pancreatic cysts and/or islet cell tumours.
  • Germline mutations of VHL tumour suppressor gene cause the VHL disease, while somatic mutations have been associated with sporadic hemangioblastomas and clear-cell renal carcinomas.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Cerebellar Neoplasms / genetics. Hemangioblastoma / genetics. Kidney Neoplasms / genetics. Promoter Regions, Genetic. Von Hippel-Lindau Tumor Suppressor Protein / genetics. von Hippel-Lindau Disease / genetics


49. Trpkov K, Yilmaz A, Uzer D, Dishongh KM, Quick CM, Bismar TA, Gokden N: Renal oncocytoma revisited: a clinicopathological study of 109 cases with emphasis on problematic diagnostic features. Histopathology; 2010 Dec;57(6):893-906
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  • [Title] Renal oncocytoma revisited: a clinicopathological study of 109 cases with emphasis on problematic diagnostic features.
  • AIM: To evaluate problematic diagnostic features in renal oncocytoma.
  • METHODS AND RESULTS: One hundred and nine cases of oncocytoma were reviewed and the problematic gross and microscopic features recorded.
  • Limited foci with chromophobe-like histology (not exceeding 5% of the neoplasm) were found in 13 (11.9%) oncocytomas.
  • After a median follow-up of 52 months (range 1-113 months), there was no disease recurrence, progression or death attributed to oncocytoma.
  • CONCLUSIONS: The recognition of the spectrum of morphological changes observed in renal oncocytoma should help pathologists establish a diagnosis of oncocytoma in problematic cases.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Kidney / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Renal Cell / metabolism. Carcinoma, Renal Cell / pathology. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Necrosis. Retrospective Studies

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  • [Copyright] © 2010 Blackwell Publishing Limited.
  • (PMID = 21166703.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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50. Radopoulos D, Tzakas K, Tahmatzopoulos A: A rare case of renal oncocytoma associated with erythrocytosis: case report. BMC Urol; 2006;6:26
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  • [Title] A rare case of renal oncocytoma associated with erythrocytosis: case report.
  • BACKGROUND: Oncocytomas are benign tumors of the kidney that are usually diagnosed postoperatively due to differential diagnostic problems from renal cell carcinoma.
  • CASE PRESENTATION: In this case report we present a unique case of a right lower pole oncocytoma associated with erythrocytosis.
  • CONCLUSION: Erythrocytosis can sometimes occur in association with renal oncocytomas.
  • [MeSH-major] Adenoma, Oxyphilic / complications. Adenoma, Oxyphilic / diagnosis. Kidney Neoplasms / complications. Kidney Neoplasms / diagnosis. Polycythemia / complications. Polycythemia / diagnosis

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  • [Cites] J Urol. 2004 Mar;171(3):1066-70 [14767272.001]
  • [Cites] Eur Urol. 1992;21(2):160-3 [1499617.001]
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  • (PMID = 16995951.001).
  • [ISSN] 1471-2490
  • [Journal-full-title] BMC urology
  • [ISO-abbreviation] BMC Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1590043
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51. Bahrami A, Truong LD, Shen SS, Krishnan B: Synchronous renal and adrenal masses: an analysis of 80 cases. Ann Diagn Pathol; 2009 Feb;13(1):9-15
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  • [Title] Synchronous renal and adrenal masses: an analysis of 80 cases.
  • Synchronous renal and adrenal masses are uncommon.
  • Although adrenal masses in the context of renal cell carcinoma (RCC) are often suspected as metastasis, other adrenal lesions with different therapeutic and prognostic implications may coexist with RCC.
  • In a retrospective review of 550 radical nephrectomies with ipsilateral adrenalectomy, 80 cases of coexisting renal and adrenal masses were identified.
  • The renal masses included 76 RCCs, 3 oncocytomas, and 1 malignant pheochromocytoma of adrenal gland involving the kidney.
  • Although the gross pathologic impression of adrenal masses in the presence of RCC was metastasis, on histologic examination, 56% of them were found to be benign lesions (mostly adrenal adenoma/hyperplasia), whereas malignant involvement from RCC was seen in 43%.
  • The benign and malignant nature of the adrenal lesions in the context of RCC could not be discriminated based on the size of adrenal mass.
  • Rare unusual combinations of renal and adrenal lesions such as RCC and adrenal histoplasmosis, RCC and adrenal myelolipoma, renal oncocytoma, and adrenal pheochromocytoma are also described.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Adrenal Glands / pathology. Carcinoma, Renal Cell / pathology. Kidney / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / surgery. Adrenalectomy. Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Staging. Nephrectomy. Pheochromocytoma / pathology. Pheochromocytoma / surgery. Retrospective Studies

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  • (PMID = 19118776.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. Sukov WR, Ketterling RP, Lager DJ, Carlson AW, Sinnwell JP, Chow GK, Jenkins RB, Cheville JC: CCND1 rearrangements and cyclin D1 overexpression in renal oncocytomas: frequency, clinicopathologic features, and utility in differentiation from chromophobe renal cell carcinoma. Hum Pathol; 2009 Sep;40(9):1296-303
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  • [Title] CCND1 rearrangements and cyclin D1 overexpression in renal oncocytomas: frequency, clinicopathologic features, and utility in differentiation from chromophobe renal cell carcinoma.
  • SUMMARY: Renal oncocytoma is a benign tumor occurring singly or as multiple synchronous lesions.
  • The histologic features of renal oncocytoma may overlap with those of chromophobe renal cell carcinoma.
  • Chromosomal translocations involving the CCND1 locus at 11q13 and overexpression of cyclin D1 occur in a subset of renal oncocytomas.
  • We evaluated a series of 63 renal oncocytomas and 36 chromophobe renal cell carcinomas and assessed the clinical features, cyclin D1 overexpression by immunohistochemistry, and alterations of the CCND1 gene by fluorescence in situ hybridization.
  • All 36 chromophobe renal cell carcinomas were negative for cyclin D1 overexpression and alterations of CCND1.
  • Of the 63 renal oncocytomas, 21 (33%) showed cyclin D1 overexpression.
  • Of 21 renal oncocytomas with cyclin D1 overexpression, a CCND1 rearrangement was detected in 12 (57%).
  • A CCND1 rearrangement was also identified in 1 (2%) of the 42 renal oncocytomas without cyclin D1 overexpression.
  • Of 42 renal oncocytomas without cyclin D1 overexpression, 16 (38%) were from patients with multiple renal oncocytomas at nephrectomy.
  • Of 21 renal oncocytomas with cyclin D1 overexpression, only 1 (5%) patient had multiple renal oncocytomas (P = .006).
  • Of the 25 patients whose original tumor showed no cyclin D1 overexpression, 8 (32%) developed a subsequent renal oncocytoma.
  • None of 15 patients whose original tumor showed cyclin D1 overexpression had a subsequent renal oncocytoma (P = .016).
  • The findings of this study suggest that renal oncocytomas lacking cyclin D1 overexpression may be associated with the development of multiple renal oncocytomas and that these patients are more likely to develop subsequent renal oncocytomas suggesting the need for more frequent clinical for these patients and little need for follow-up in patients with renal oncocytomas overexpressing cyclin D1.
  • The data also show that cyclin D1 overexpression and CCND1 rearrangements by fluorescence in situ hybridization are absent in chromophobe renal cell carcinoma, suggesting that these are useful when differentiating between renal oncocytoma and chromophobe renal cell carcinoma.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Carcinoma, Renal Cell / genetics. Cyclin D1 / genetics. Gene Rearrangement. Kidney Neoplasms / genetics
  • [MeSH-minor] Case-Control Studies. Chromosomes, Human, Pair 11 / metabolism. Cytogenetic Analysis / methods. Diagnosis, Differential. Female. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Karyotyping. Male. Nephrectomy. Translocation, Genetic. Tumor Cells, Cultured


53. Gassler N, Haferkamp A, Flechtenmacher C, Hohenfellner M, Schirmacher P, Autschbach F: [Renal oncocytoma with metastasis from breast carcinoma: a contribution to the differential diagnosis of tumourous lesions of the kidney]. Pathologe; 2006 May;27(3):217-21
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  • [Title] [Renal oncocytoma with metastasis from breast carcinoma: a contribution to the differential diagnosis of tumourous lesions of the kidney].
  • [Transliterated title] Onkozytom der Niere mit Metastase eines Mammakarzinoms : Differenzialdiagnose tumoröser Läsionen der Niere.
  • The case of a renal oncocytoma involvement by metastasis from breast carcinoma in a 83-year-old woman is reported.
  • In conclusion, metastasis of breast carcinoma to a benign renal tumour is very rare.
  • [MeSH-major] Adenoma, Oxyphilic / secondary. Breast Neoplasms / pathology. Kidney Neoplasms / secondary. Neoplasm Metastasis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Humans

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  • (PMID = 16642392.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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54. Zbar B, Glenn G, Merino M, Middelton L, Peterson J, Toro J, Coleman J, Pinto P, Schmidt LS, Choyke P, Linehan WM: Familial renal carcinoma: clinical evaluation, clinical subtypes and risk of renal carcinoma development. J Urol; 2007 Feb;177(2):461-5; discussion 465
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  • [Title] Familial renal carcinoma: clinical evaluation, clinical subtypes and risk of renal carcinoma development.
  • PURPOSE: Familial renal carcinoma is defined as families with 2 or more individuals with renal cell carcinoma without evidence of known hereditary renal carcinoma syndromes.
  • To better characterize this familial cancer we reviewed renal carcinoma families evaluated at the National Cancer Institute between 1990 and 2004 to identify distinctive features of these families.
  • We also determined the risk of renal carcinoma in first-degree relatives of affected family members.
  • MATERIALS AND METHODS: We evaluated 141 at risk asymptomatic relatives of affected individuals from 50 families with 2 or more members with renal carcinoma.
  • Histology slides of renal tumors from affected family members were reviewed.
  • At risk members from renal carcinoma families were screened for occult renal neoplasms by renal ultrasound and computerized tomography.
  • DNA from select families was tested for germline mutations of known renal carcinoma genes when clinically indicated and constitutional cytogenetic analysis was performed to search for germline chromosome alterations.
  • RESULTS: Familial renal carcinoma families could be subdivided into subtypes based on tumor multiplicity and renal tumor histology.
  • Of 141 at risk members of renal carcinoma families screened for occult renal tumors 2 were found to have occult renal tumors, which were identified as renal oncocytoma and a solid tumor that was not resected, respectively.
  • No histologically confirmed occult renal carcinomas were detected in at risk family members.
  • Several families previously classified as having familial renal carcinoma were found on further evaluation to have hereditary renal cancer syndromes.
  • CONCLUSIONS: Familial renal carcinoma is a heterogeneous clinical and pathological entity.
  • Familial renal carcinoma was subdivided into groups based on tumor multiplicity and tumor pathology.
  • The empirical risk of histologically documented renal carcinoma in first-degree relatives who were members of familial renal carcinoma families was less than 1:141.
  • One renal oncocytoma and 1 small solid renal tumor were detected.
  • [MeSH-major] Carcinoma, Renal Cell / genetics. Kidney Neoplasms / genetics

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  • (PMID = 17222609.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CO / N01-CO-12400; United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] United States
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55. Ivey BS, Devarajan K, Sundaram CP: Bilateral oncocytoma and the value of needle biopsy. Can J Urol; 2010 Apr;17(2):5131-4
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  • [Title] Bilateral oncocytoma and the value of needle biopsy.
  • INTRODUCTION: Renal oncocytoma represents a diagnostic challenge to urologists.
  • We present three patients with bilateral renal oncocytomas.
  • CASES: All three patients presented with bilateral renal masses and through surgical means, were diagnosed with oncocytoma.
  • Renal biopsies were used to diagnose oncocytoma in the contralateral kidney.
  • DISCUSSION: Considering oncocytoma represents up to 16% of renal masses, there is overtreatment of benign disease due the difficulty in distinguishing between histologies on radiographs.
  • Even when the diagnosis of oncocytoma is made, concurrent renal cell carcinoma can be found in a small subset of patients.
  • The value of renal biopsy in these patients thus becomes increasingly important.
  • Accuracy in establishing a diagnosis is better than 70% in most series.
  • Tissue acquisition remains a barrier to accurate diagnosis.
  • Although not routine, patients with bilateral masses or impaired renal function may be candidates for renal biopsy.
  • CONCLUSIONS: Oncocytoma in the setting of bilateral renal masses presents a difficult clinical scenario.
  • The clinician must exclude renal cell carcinoma from the differential diagnosis.
  • Renal biopsy represents a safe and accurate method towards that end so that patients can be followed radiographically.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Biopsy, Needle / methods. Kidney Neoplasms / pathology

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  • (PMID = 20398456.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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56. Németh I, Sükösd F, Béli L, Kiss A, Pajor L, Mikó T, Iványi B: [Adult renal neoplasms in the material of the Pathology Department of the Szeged University]. Orv Hetil; 2005 Apr 3;146(14):653-8
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  • [Title] [Adult renal neoplasms in the material of the Pathology Department of the Szeged University].
  • AIMS: The authors investigated the frequencies of the various histological types of adult renal tumours.
  • Among the malignant tumours, the frequency of renal cell carcinomas was 91.1% (n = 371).
  • 88.4% of the renal cell carcinomas (n = 328) were of conventional type, 5.6% (n = 21) were papillary and 4% (n = 15) were chromophobe.
  • As far as benign tumours are concerned (13.2%, n = 62), oncocytomas (n = 37, 7.8% of all the tumours) affected mainly females, whereas angiomyolipomas (n = 21, 4.4% of all the tumours) occurred in females only.
  • In 13 oncocytoma cases, the tumours were initially diagnosed as malignant.
  • CONCLUSIONS: Adult malignant renal tumours affect mainly patients around the age of 60.
  • The commonest diagnosis was clear cell carcinoma of conventional type.
  • In comparison with the literature data, oncocytomas were relatively common (8% instead of 3%), and not rarely, it was difficult to distinguish them from renal cell carcinomas.
  • [MeSH-major] Carcinoma / epidemiology. Carcinoma / pathology. Kidney Neoplasms / epidemiology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Clear Cell / epidemiology. Adenocarcinoma, Clear Cell / pathology. Adenoma, Chromophobe / epidemiology. Adenoma, Chromophobe / pathology. Adenoma, Oxyphilic / epidemiology. Adenoma, Oxyphilic / pathology. Adult. Aged. Angiomyolipoma / epidemiology. Angiomyolipoma / pathology. Carcinoma, Papillary / epidemiology. Carcinoma, Papillary / pathology. Carcinoma, Renal Cell / epidemiology. Carcinoma, Renal Cell / pathology. Carcinoma, Transitional Cell / epidemiology. Carcinoma, Transitional Cell / pathology. Female. Humans. Hungary / epidemiology. Male. Middle Aged. Nephrectomy

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  • (PMID = 15889540.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
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57. DeWitt J, Gress FG, Levy MJ, Hernandez LV, Eloubeidi MA, Mishra G, Sherman S, Al-Haddad MA, LeBlanc JK: EUS-guided FNA aspiration of kidney masses: a multicenter U.S. experience. Gastrointest Endosc; 2009 Sep;70(3):573-8
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  • [Title] EUS-guided FNA aspiration of kidney masses: a multicenter U.S. experience.
  • BACKGROUND: Tissue sampling of renal lesions is traditionally performed with percutaneous US or CT guidance.
  • To date, only 3 known cases of EUS-guided FNA (EUS-FNA) of a renal mass have been reported.
  • OBJECTIVE: To describe a multicenter experience with the indications, yield, and complications from attempted EUS-FNA of a kidney mass.
  • PATIENTS: Consecutive subjects undergoing attempted EUS-FNA of a kidney mass.
  • Endosonographers at 15 other teaching hospitals were contacted regarding EUS findings and follow-up of any EUS-guided renal biopsies previously attempted or considered at that institution.
  • INTERVENTIONS: EUS-FNA of a kidney mass.
  • MAIN OUTCOME MEASUREMENTS: Biopsy indications, yield, diagnosis, and complications.
  • Kidney masses (median diameter 32 mm; range 11-60 mm) were located in the upper (n = 12) and lower (n = 3) poles of the left (n = 10) and right (n = 5) kidneys, respectively.
  • Results of EUS-FNA (median 3 passes; range 2-4 passes) in 13 (87%) procedures were diagnostic of (n = 7) or highly suspicious for (n = 1) renal cell carcinoma (RCC), atypical cells (n = 2), oncocytoma (n = 1), benign cyst (n = 1), and nondiagnostic (n = 1).
  • Surgical resection confirmed RCC in 7 patients in whom preoperative EUS-FNA demonstrated RCC (n = 5) or oncocytoma (n = 1) or was not performed (n = 1).
  • CONCLUSIONS: EUS-FNA of renal masses is rarely performed at the U.S. teaching hospitals surveyed.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Endosonography / methods. Kidney Neoplasms / pathology. Kidney Neoplasms / ultrasonography
  • [MeSH-minor] Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / ultrasonography. Aged. Aged, 80 and over. Carcinoma, Renal Cell / pathology. Carcinoma, Renal Cell / ultrasonography. Cohort Studies. Confidence Intervals. Female. Follow-Up Studies. Hospitals, Teaching. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Probability. Retrospective Studies. Risk Assessment. Sensitivity and Specificity. United States

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  • (PMID = 19560139.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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58. Snyder ME, Bach A, Kattan MW, Raj GV, Reuter VE, Russo P: Incidence of benign lesions for clinically localized renal masses smaller than 7 cm in radiological diameter: influence of sex. J Urol; 2006 Dec;176(6 Pt 1):2391-5; discussion 2395-6
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  • [Title] Incidence of benign lesions for clinically localized renal masses smaller than 7 cm in radiological diameter: influence of sex.
  • PURPOSE: We determined the incidence of benign renal lesions in patients undergoing definitive surgery for localized renal masses 7 cm or less in maximum radiological diameter, and assessed preoperative and clinical parameters associated with benign histology.
  • We excluded 208 patients with lesions more than 7 cm in maximum radiological diameter, 17 with evidence of renal vein or vena caval invasion, 75 with suspected or documented metastatic disease, 28 with a history of renal cell carcinoma and 41 with no available imaging.
  • Logistic regression was done to determine clinical factors associated with benign renal masses, including radiological tumor size, cystic vs solid appearance, patient sex, age, presenting symptoms and race.
  • RESULTS: Of 815 nephrectomies in our data set 134 (16.4%) were associated with benign lesions, including oncocytoma in 87 (10.7%), angiomyolipoma in 17 (2%), simple cysts in 10 (1.2%), metanephric adenoma in 8 (1%), cystic nephroma in 5 (0.6%) and other in 7.
  • On multivariate logistic regression analysis only sex was significantly associated with benign histology with females having an OR of 1.8 (95% CI 1.2 to 2.6, p = 0.002).
  • Tumor size was not independently associated with benign histology (p = 0.13).
  • CONCLUSIONS: A significant number (16.4%) of benign lesions less than 7 cm in radiological diameter were operated on based on suspicious preoperative imaging.
  • Women had almost twice the likelihood of having a benign lesion.
  • [MeSH-major] Adenoma, Oxyphilic / radiography. Carcinoma, Renal Cell / radiography. Kidney Neoplasms / radiography

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  • (PMID = 17085108.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Perepletchikov AM, Alroy J, Ucci A: Diagnostic utility of CD10, CD3 and electron microscopy of renal cortical neoplasms with oncocytic features. Pathol Res Pract; 2010 Jun 15;206(6):384-6
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  • [Title] Diagnostic utility of CD10, CD3 and electron microscopy of renal cortical neoplasms with oncocytic features.
  • No currently defined imaging techniques can reliably distinguish between oncocytoma and epithelial malignant lesions with oncocytic features in the kidney; therefore, patients must undergo resection or, in certain circumstances, biopsy to definitively establish diagnosis.
  • Immunohistochemical staining for CD10 and CD3, evaluation of the staining pattern and intensity, and relevant morphologic appearance are helpful diagnostic tools in discriminating between renal cell carcinoma with oncocytic features and renal oncocytoma.
  • Accurate determination of the tumor origin would allow for the use of limited nephron sparing and laparoscopic surgical approaches to treat appropriately.
  • [MeSH-major] Antigens, CD3 / biosynthesis. Carcinoma, Renal Cell / ultrastructure. Kidney Neoplasms / ultrastructure. Neprilysin / biosynthesis
  • [MeSH-minor] Adenoma, Oxyphilic. Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission

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  • [Copyright] Published by Elsevier GmbH.
  • (PMID = 19942355.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD3; 0 / Biomarkers, Tumor; EC 3.4.24.11 / Neprilysin
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60. Mete O, Kilicaslan I, Gulluoglu MG, Uysal V: Can renal oncocytoma be differentiated from its renal mimics? The utility of anti-mitochondrial, caveolin 1, CD63 and cytokeratin 14 antibodies in the differential diagnosis. Virchows Arch; 2005 Dec;447(6):938-46
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  • [Title] Can renal oncocytoma be differentiated from its renal mimics? The utility of anti-mitochondrial, caveolin 1, CD63 and cytokeratin 14 antibodies in the differential diagnosis.
  • Among the epithelial renal tumours with eosinophilic cytoplasm, the main differential diagnostic problem arises between renal oncocytomas (ROs) and eosinophilic variants of chromophobe renal cell carcinomas (RCCs).
  • We investigated the possible role of anti-mitochondrial (AMA), anti-caveolin 1 (CAV1), anti-CD63 (CD63) and anti-cytokeratin 14 (CK14) antibodies in the differential diagnosis of eosinophilic epithelial tumours and applied the Muller and Mowry modification of Hale's colloidal iron stain (HCI).
  • We showed CK14 antibody not to be useful in the differential diagnosis of the eosinophilic epithelial renal tumours.
  • [MeSH-major] Adenoma, Oxyphilic / metabolism. Adenoma, Oxyphilic / pathology. Biomarkers, Tumor / analysis. Kidney Neoplasms / metabolism. Kidney Neoplasms / pathology
  • [MeSH-minor] Antigens, CD / metabolism. Antigens, CD63. Carcinoma, Renal Cell / metabolism. Carcinoma, Renal Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratins / metabolism. Male. Middle Aged. Mitochondria / immunology. Platelet Membrane Glycoproteins / metabolism. Sensitivity and Specificity

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  • (PMID = 16133362.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD63; 0 / Biomarkers, Tumor; 0 / CD63 protein, human; 0 / Platelet Membrane Glycoproteins; 68238-35-7 / Keratins
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61. Akbulut S, Senol A, Cakabay B, Sezgin A: Giant renal oncocytoma: a case report and review of the literature. J Med Case Rep; 2010;4:52
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  • [Title] Giant renal oncocytoma: a case report and review of the literature.
  • INTRODUCTION: Renal oncocytomas are benign neoplasms derived from cells of the distal renal tubule, and comprise 5% to 7% of primary renal neoplasms.
  • In this case report, we present a case of a patient with a giant oncocytoma arising from her left kidney.
  • Computed tomography revealed a mass with regular outlines, measuring 18 x 11 x 12 cm, associated with the left kidney, and causing marked hydroureteronephrosis.
  • The immunohistopathology of the mass was consistent with renal oncocytoma.
  • CONCLUSION: To the best of our knowledge, this is the second largest renal oncocytoma described in the English language literature.
  • This is also the first reported giant oncocytoma that presented during pregnancy.

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  • (PMID = 20205900.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2827435
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62. Yen TH, Chen Y, Fu JF, Weng CH, Tian YC, Hung CC, Lin JL, Yang CW: Proliferation of myofibroblasts in the stroma of renal oncocytoma. Cell Prolif; 2010 Jun;43(3):287-96
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  • [Title] Proliferation of myofibroblasts in the stroma of renal oncocytoma.
  • OBJECTIVES: Myofibroblasts are a vital component of stroma of many malignant neoplasms, but it is not yet established whether stromal myofibroblasts also exist in benign tumours such as oncocytoma of the kidney.
  • MATERIALS AND METHODS: Histomorphological and immunohistochemical analysis of 16 renal oncocytomas diagnosed at Chang Gung Memorial Hospital, Taiwan, has been performed.
  • RESULTS: Renal oncocytomas were composed of oncocytes, large cells with granular eosinophilic cytoplasm, arranged mostly in sheets, in tubulocystic or combined pattern.
  • Wnt/beta-catenin signalling was not implicated in this neoplasm, as there was no loss of E-cadherin membranous localization or expression of intranuclear beta-catenin in the cells.
  • CONCLUSIONS: Renal oncocytomas were composed of two independent compartments: benign oncocytes and pronounced fibrotic stroma, which consisted of proliferating myofibroblasts (SMA- and MIB-1-positive) which were associated with excessive deposition of extracellular matrix (periodic acid Schiff-component, collagen I-, collagen III- and fibronectin-positive, and desmin- and human caldesmon-negative).
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Fibroblasts / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Cell Proliferation. Extracellular Matrix / metabolism. Extracellular Matrix / pathology. Extracellular Matrix Proteins / metabolism. Female. Humans. Male. Middle Aged. Myoblasts / metabolism. Myoblasts / pathology. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / physiopathology. Stromal Cells / metabolism. Stromal Cells / pathology

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  • (PMID = 20412129.001).
  • [ISSN] 1365-2184
  • [Journal-full-title] Cell proliferation
  • [ISO-abbreviation] Cell Prolif.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Extracellular Matrix Proteins
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63. Meyer PN, Cao Y, Jacobson K, Krausz T, Flanigan RC, Picken MM: Chromosome 1 analysis in chromophobe renal cell carcinomas with tissue microarray (TMA)-facilitated fluorescence in situ hybridization (FISH) demonstrates loss of 1p/1 which is also present in renal oncocytomas. Diagn Mol Pathol; 2008 Sep;17(3):141-4
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  • [Title] Chromosome 1 analysis in chromophobe renal cell carcinomas with tissue microarray (TMA)-facilitated fluorescence in situ hybridization (FISH) demonstrates loss of 1p/1 which is also present in renal oncocytomas.
  • Morphologic overlap between chromophobe renal cell carcinoma (ChRCC) and renal oncocytomas (RO) has been widely recognized.
  • Whether these tumors are genetically related and represent a spectrum of benign to malignant tumor progression remains an open question.
  • FISH analysis showed an abnormal chromosome 1 in 20/21 (95%) ChRCCs as follows: 18 tumors (85%) had loss of entire chromosome 1, 2 tumors (10%) had loss of 1p36.3 only, and 1 tumor (5%) was apparently diploid for chromosome 1.
  • These results provide further evidence to support a genetic similarity between chromophobe carcinoma and oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Carcinoma, Renal Cell / genetics. Chromosome Deletion. Chromosomes, Human, Pair 1 / genetics. Kidney Neoplasms / genetics

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  • (PMID = 18382368.001).
  • [ISSN] 1533-4066
  • [Journal-full-title] Diagnostic molecular pathology : the American journal of surgical pathology, part B
  • [ISO-abbreviation] Diagn. Mol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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64. Brunelli M, Delahunt B, Gobbo S, Tardanico R, Eccher A, Bersani S, Cossu-Rocca P, Parolini C, Balzarini P, Menestrina F, Cheng L, Eble JN, Martignoni G: Diagnostic usefulness of fluorescent cytogenetics in differentiating chromophobe renal cell carcinoma from renal oncocytoma: a validation study combining metaphase and interphase analyses. Am J Clin Pathol; 2010 Jan;133(1):116-26
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  • [Title] Diagnostic usefulness of fluorescent cytogenetics in differentiating chromophobe renal cell carcinoma from renal oncocytoma: a validation study combining metaphase and interphase analyses.
  • We investigated the usefulness of interphase fluorescence in situ hybridization (FISH) analysis to differentiate between 11 chromophobe renal carcinomas and 12 renal oncocytomas, showing different clinical outcomes, when compared with conventional metaphase cytogenetics by karyotyping.
  • Karyotypically, 3 chromophobe renal cell carcinomas showed losses of chromosomes, 3 were polyploid, 1 was normal, and 4 failed to grow.
  • FISH on chromophobe renal cell carcinomas showed a high percentage of cases (10/11 [91%]) with multiple numeric losses among chromosomes 1, 2, 6, 10, and 17; this interphase pattern was observed irrespective of the 3 different metaphase karyotypes.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Chromosome Aberrations. In Situ Hybridization, Fluorescence. Kidney Neoplasms / diagnosis
  • [MeSH-minor] DNA, Neoplasm / analysis. Diagnosis, Differential. Humans. Interphase / genetics. Metaphase / genetics. Tissue Array Analysis


65. Compérat EV, Vasiliu V, Ferlicot S, Camparo P, Sibony M, Vieillefond A: [Tumors of the kidneys: new entities]. Ann Pathol; 2005 Apr;25(2):117-33
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  • Since 1998 new entities have surfaced in renal tumor classification and have been included in the WHO 2004 classification.
  • In this article, we will discuss the following entities: multilocular clear cell renal carcinoma, Xp11 translocation carcinoma, low grade mucinous tubular carcinoma, epithelioid angiomyolipoma, benign mixed epithelial and stromal tumor.
  • We will investigate new concepts of hybrid oncocytoma and chromophobe renal cell carcinoma and the syndrome of Birt-Hogg-Dube which is associated to kidney tumors.
  • [MeSH-major] Kidney Neoplasms / classification. Kidney Neoplasms / pathology

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  • (PMID = 16142163.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 77
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66. Jaff A, Molinié V, Mellot F, Guth A, Lebret T, Scherrer A: Evaluation of imaging-guided fine-needle percutaneous biopsy of renal masses. Eur Radiol; 2005 Aug;15(8):1721-6
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  • [Title] Evaluation of imaging-guided fine-needle percutaneous biopsy of renal masses.
  • To evaluate the utility of imaging-guided fine-needle percutaneous biopsy of renal masses, we conducted a prospective analysis of our imaging-guided procedures from January 1999 to February 2003.
  • The mean tumor size was 33 mm.
  • Biopsy findings were positive for malignancy in 31 cases; histologic diagnoses included renal cell carcinoma (n=23), transitional cell carcinoma (n=5), and metastasis (n=3).
  • Biopsy revealed 15 benign diagnoses: oncocytoma (n=6), hemorrhagic renal cyst (n=3), chronic nephritis (n=3), angiomyolipoma (n=2), and mycotic renal abscess (n=1).
  • The average follow-up period for patients with benign diagnoses was 16 months.
  • Biopsy results showed normal renal parenchyma in eight of 54 procedures, all of which had recuperated by subsequent biopsies.
  • Imaging-guided percutaneous core biopsy is a safe and accurate method for the evaluation of renal masses.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Kidney Diseases / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Kidney Neoplasms / diagnosis. Kidney Neoplasms / diagnostic imaging. Male. Middle Aged. Tomography, X-Ray Computed. Ultrasonography

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  • [CommentIn] Eur Radiol. 2006 Aug;16(8):1857 [16395535.001]
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  • (PMID = 15627185.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
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67. Al-Ahmadie HA, Olgac S, Gregor PD, Tickoo SK, Fine SW, Kondagunta GV, Scher HI, Morris MJ, Russo P, Motzer RJ, Reuter VE: Expression of prostate-specific membrane antigen in renal cortical tumors. Mod Pathol; 2008 Jun;21(6):727-32
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  • [Title] Expression of prostate-specific membrane antigen in renal cortical tumors.
  • Prostate-specific membrane antigen is a type II membrane glycoprotein that is expressed in benign and neoplastic prostatic tissue and has been recently shown to be also expressed in the neovasculature of various solid malignant tumors including renal cell carcinoma.
  • Renal cell carcinoma is a heterogeneous group of tumors with distinct morphologic and genetic characteristics and clinical behaviors.
  • The study included 30 clear cell renal cell carcinomas, and 15 of each of papillary and chromophobe renal cell carcinoma and oncocytoma.
  • In all cases, immunoreactivity was detected only in the tumor-associated neovasculature and not in tumor cells.
  • Clear cell renal cell carcinoma showed the most diffuse staining pattern, where 24/30 cases or 80% had >50% reactive vessels, followed by chromophobe renal cell carcinoma (9/15; 60%) and oncocytoma (5/15, 33%).
  • No diffuse staining was detected in any of the papillary renal cell carcinomas and only focal staining was detected in 11 cases (11/15; 73%).
  • Staining intensity was the strongest in clear cell renal cell carcinoma (25/30; 83%) followed by chromophobe renal cell carcinoma (9/15; 60%), oncocytoma (8/15, 53%) and papillary renal cell carcinoma (5/15; 33%).
  • In summary, prostate-specific membrane antigen is expressed in tumor-associated neovasculature of the majority of renal cortical tumors and is most diffusely and intensely expressed in clear cell renal cell carcinoma and least in papillary renal cell carcinoma.
  • The differences in the expression of prostate-specific membrane antigen in renal cell carcinoma subtypes provide further evidence of the biological diversity of these tumors, and diagnostic and therapeutic applications of such expression can be expanded to include subtypes of renal cell carcinoma.
  • [MeSH-major] Antigens, Surface / biosynthesis. Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / metabolism. Carcinoma, Renal Cell / pathology. Glutamate Carboxypeptidase II / biosynthesis. Kidney Neoplasms / metabolism. Kidney Neoplasms / pathology

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  • (PMID = 18344976.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Surface; 0 / Biomarkers, Tumor; EC 3.4.17.21 / Glutamate Carboxypeptidase II; EC 3.4.17.21 / glutamate carboxypeptidase II, human
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68. Dvorakova M, Dhir R, Bastacky SI, Cieply KM, Acquafondata MB, Sherer CR, Mercuri TL, Parwani AV: Renal oncocytoma: a comparative clinicopathologic study and fluorescent in-situ hybridization analysis of 73 cases with long-term follow-up. Diagn Pathol; 2010;5:32
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  • [Title] Renal oncocytoma: a comparative clinicopathologic study and fluorescent in-situ hybridization analysis of 73 cases with long-term follow-up.
  • Clinical studies have confirmed that renal oncocytoma (RO) is a benign neoplasm with excellent prognosis.
  • In diagnostically challenging cases of renal oncocytic epithelial neoplasms, fluorescent in-situ hybridization (FISH) is increasingly being used and its ability to distinguish RO from chromophobe renal cell carcinoma (ChRCC) has been documented.
  • FISH results, even those showing significant chromosomal abnormalities, should not alter the primarily morphology-based diagnosis of RO.
  • [MeSH-major] Carcinoma, Renal Cell / genetics. Chromosome Aberrations. Chromosomes, Human, Pair 1. Chromosomes, Human, Pair 17. In Situ Hybridization, Fluorescence
  • [MeSH-minor] Adenoma, Oxyphilic / genetics. Adenoma, Oxyphilic / mortality. Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / surgery. Adult. Aged. Aged, 80 and over. Chromosomes, Human, Pair 2. Female. Fixatives. Follow-Up Studies. Formaldehyde. Humans. Kidney Neoplasms / genetics. Kidney Neoplasms / mortality. Kidney Neoplasms / pathology. Kidney Neoplasms / surgery. Male. Middle Aged. Nephrectomy. Paraffin Embedding. Predictive Value of Tests. Time Factors. Tissue Fixation. Treatment Outcome

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  • (PMID = 20497539.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Fixatives; 1HG84L3525 / Formaldehyde; Oncocytoma, renal
  • [Other-IDs] NLM/ PMC2881070
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69. Hes O, Michal M, Síma R, Vanecek T, Brunelli M, Martignoni G, Kuroda N, Alvarado Cabrero I, Perez-Montiel D, Hora M, Urge T, Dvorák M, Jarosová M, Yang X: Renal oncocytoma with and without intravascular extension into the branches of renal vein have the same morphological, immunohistochemical, and genetic features. Virchows Arch; 2008 Feb;452(2):193-200
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  • [Title] Renal oncocytoma with and without intravascular extension into the branches of renal vein have the same morphological, immunohistochemical, and genetic features.
  • We attempted to investigate the clinicopathological correlation of renal oncocytoma (RO) with renal vein extension.
  • We identified seven ROs with extension into the branches of renal vein.
  • Renal vein extension was grossly suspected in five of seven cases and histologically confirmed in all seven cases.
  • Tumor cells were positive for cytokeratins, mitochondrial-antigen (MIA), epithelial membrane antigen (EMA), and parvalbumin; five of seven tumors were focally positive for CD117.
  • (1) renal oncocytomas may have intravascular extension to the branches of the renal vein;.
  • (2) renal oncocytomas with intravascular extension to the branches of the renal vein have the same morphological, immunohistochemical, and cytogenetic findings as have their counterparts without evidence of intravascular invasion;.
  • (3) the absence of metastases suggests an overall benign behavior of this tumor, but this has to be substantiated by further studies with a long-term follow-up; and (4) in a renal tumor with granular cytoplasm showing renal vein extension, it is necessary to carefully exclude renal cell carcinomas such as chromophobe RCC, oncocytic variant of papillary RCC, and granular variant of clear cell RCC.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Kidney Neoplasms / pathology. Renal Veins / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Chromosome Aberrations. Cytoplasm / ultrastructure. DNA, Neoplasm / analysis. Female. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Mitochondria / ultrastructure. Neoplasm Invasiveness. Nephrectomy


70. Han XN, Peng LR, Liu GH, Wang J: [Multiphasic spiral CT scanning features in 100 patients with small renal cell carcinoma]. Zhonghua Zhong Liu Za Zhi; 2007 May;29(5):382-5
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  • [Title] [Multiphasic spiral CT scanning features in 100 patients with small renal cell carcinoma].
  • OBJECTIVE: To investigate the role of multiphasic spiral computed tomography (SCT) in the differential diagnosis of small renal cell carcinoma.
  • METHODS: The data of 100 patients with small renal cell carcinoma (< or = 3.0 cm) proved by pathology were retrospectively reviewed in order to analyze the features of SCT during plain, corticomedullary and excretory phases.
  • RESULTS: There were 38 tumor masses in the left kidney and 62 in the right one.
  • According to the 2004 WHO histological classification criteria for the tumors of the kidney.
  • Seventy-six patients had clear cell renal cell carcinoma, 4 multilocular clear cell renal cell carcinomas, 9 papillary renal cell carcinoma, 4 chromophobe renal cell carcinomas and 7 unclassified renal cell carcinomas.
  • Clear cell renal cell carcinoma exhibited rich blood supply and inhomogeneous density due to hemorrhage, necrosis or cystic degeneration.
  • Multilocular clear cell renal cell carcinoma presented as a multilocular cystic mass with thin wall and septa, instead of an expansile nodule.
  • Papillary renal cell carcinoma showed inhomogeneous density and hypovascular distribution.
  • Chromophobe renal cell carcinoma was relatively homogeneous and hypovascular.
  • Compared with clear cell renal cell carcinoma, unclassified renal cell carcinoma showed inhomogeneous density and hypervascular distribution with more invading growth features than the other subtypes.
  • CONCLUSION: Commonly encountered subtypes of the small renal cell carcinoma exhibit their own specific features in multiphasic spiral CT, which may be helpful in differential diagnosis, but each subtype should be differentiated from the renal oncocytoma, cystic nephroma, complex renal cyst, renal angiomyolipoma with minimal fat and renal infiltrating urothelial carcinoma.
  • [MeSH-major] Carcinoma, Renal Cell / radiography. Kidney Neoplasms / radiography. Tomography, Spiral Computed / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Papillary / radiography. Child. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Prognosis. Retrospective Studies

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  • (PMID = 17892138.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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71. Jayaratna I, Munver R, Disick G, Han MW, Sawczuk I: Paraneoplastic hypertension associated with renal oncocytoma: management with cryoablation. Urology; 2009 Jan;73(1):209.e9-11
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  • [Title] Paraneoplastic hypertension associated with renal oncocytoma: management with cryoablation.
  • Paraneoplastic hypertension associated with a renal oncocytoma is an unreported syndrome.
  • We report a unique case of a patient with multidrug-resistant hypertension who was found to have a solitary renal mass.
  • Histologic review of intraoperative biopsy specimens revealed findings consistent with renal oncocytoma.
  • To our knowledge, this is the first report of hypertension in the setting of a renal oncocytoma, with subsequent improvement of this paraneoplastic syndrome after cryoablation.
  • [MeSH-major] Adenoma, Oxyphilic / complications. Adenoma, Oxyphilic / surgery. Cryosurgery. Hypertension / etiology. Hypertension / surgery. Kidney Neoplasms / complications. Kidney Neoplasms / surgery. Paraneoplastic Syndromes / etiology. Paraneoplastic Syndromes / surgery


72. Scialpi M, Cardone G, Barberini F, Piscioli I, Rotondo A: Renal oncocytoma: misleading diagnosis of benignancy by using angular interface sign at MR imaging. Radiology; 2010 Nov;257(2):587-8; author reply 588
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  • [Title] Renal oncocytoma: misleading diagnosis of benignancy by using angular interface sign at MR imaging.
  • [MeSH-major] Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Contrast Media. Diagnosis, Differential. Gadolinium DTPA. Humans. Kidney Diseases / diagnosis. Kidney Diseases / pathology. Predictive Value of Tests

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  • [CommentOn] Radiology. 2010 May;255(2):501-7 [20160001.001]
  • (PMID = 20959552.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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73. Zubakov D, Stupar Z, Kovacs G: Differential expression of a new isoform of DLG2 in renal oncocytoma. BMC Cancer; 2006;6:106
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  • [Title] Differential expression of a new isoform of DLG2 in renal oncocytoma.
  • BACKGROUND: Renal oncocytoma, a benign tumour of the kidney, may pose a differential diagnostic problem due to overlapping phenotype with chromophobe renal cell carcinoma or other types of renal cell tumours.
  • METHODS: In the current study we applied various techniques, including Affymetrix microarray hybridization and semiquantitative RT-PCR, to identify genes expressed differentially in renal oncocytomas.
  • Subsequently, we used RACE and Northern blot hybridization to characterize the potential candidates for molecular diagnosis.
  • The new isoform is specifically upregulated in renal oncocytoma, whereas the known DLG2 gene is downregulated in this type of kidney tumour.
  • CONCLUSION: The new isoform of DLG2 is the promising candidate gene for molecular differential diagnostics of renal oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / genetics. Guanylate Kinase / genetics. Kidney Neoplasms / diagnosis. Kidney Neoplasms / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / genetics. Diagnosis, Differential. Down-Regulation. Genetic Markers. Humans. Nucleic Acid Amplification Techniques. Oligonucleotide Array Sequence Analysis. Protein Isoforms. Reverse Transcriptase Polymerase Chain Reaction. Up-Regulation

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  • (PMID = 16640776.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Genetic Markers; 0 / Protein Isoforms; 0 / Tumor Suppressor Proteins; EC 2.7.4.8 / DLG2 protein, human; EC 2.7.4.8 / Guanylate Kinase
  • [Other-IDs] NLM/ PMC1524971
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74. Rohan S, Tu JJ, Kao J, Mukherjee P, Campagne F, Zhou XK, Hyjek E, Alonso MA, Chen YT: Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes. Clin Cancer Res; 2006 Dec 1;12(23):6937-45
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  • [Title] Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes.
  • PURPOSE: To compare gene expression profiles of chromophobe renal cell carcinoma (RCC) and benign oncocytoma, aiming at identifying differentially expressed genes.
  • EXPERIMENTAL DESIGN: Nine cases each of chromophobe RCC and oncocytoma were analyzed by oligonucleotide microarray.
  • Candidate genes that showed consistent differential expression were validated by reverse transcription-PCR using 25 fresh-frozen and 15 formalin-fixed, paraffin-embedded tumor samples.
  • RESULTS: Unsupervised hierarchical clustering separated the chromophobe RCC and oncocytoma into two distinct groups.
  • By a combination of data analysis approaches, we identified 11 candidate genes showing consistent differential expression between chromophobe RCC and oncocytoma.
  • Five of these genes, AP1M2, MAL2, PROM2, PRSS8, and FLJ20171, were shown to effectively separate these two tumor groups by quantitative reverse transcription-PCR using fresh tissue samples, with similar trends seen on formalin-fixed tissues.
  • Immunohistochemical analysis revealed selective expression of MAL2 and claudin 8 in distal renal tubules, with MAL2 antibody showing differential expression between chromophobe RCC and oncocytoma.
  • Functional analyses suggest that genes encoding tight junction proteins and vesicular membrane trafficking proteins, normally expressed in distal nephrons, are retained in chromophobe RCC and lost or consistently down-regulated in oncocytoma, indicating that these two tumor types, believed to be both derived from distal tubules, are likely distinctive in their histogenesis.
  • CONCLUSIONS: We showed that chromophobe RCC and oncocytoma are distinguishable by mRNA expression profiles and a panel of gene products potentially useful as diagnostic markers were identified.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Carcinoma, Renal Cell / genetics. Gene Expression Profiling. Kidney Neoplasms / genetics. Membrane Proteins / genetics. Thyroid Neoplasms / genetics. Vesicular Transport Proteins / genetics

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  • (PMID = 17145811.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AP1M2 protein, human; 0 / Adaptor Protein Complex 1; 0 / Adaptor Protein Complex mu Subunits; 0 / FLJ20171 protein, human; 0 / MAL2 protein, human; 0 / Membrane Glycoproteins; 0 / Membrane Proteins; 0 / Myelin and Lymphocyte-Associated Proteolipid Proteins; 0 / PROM2 protein, human; 0 / Proteolipids; 0 / RNA, Messenger; 0 / RNA-Binding Proteins; 0 / Vesicular Transport Proteins; EC 3.4.21.- / Serine Endopeptidases; EC 3.4.21.- / prostasin
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75. Deshpande A, Munshi M: Renal oncocytoma with hyaline globules: cytologic diagnosis by guided fine needle aspiration, a case report. Indian J Pathol Microbiol; 2005 Apr;48(2):230-5
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  • [Title] Renal oncocytoma with hyaline globules: cytologic diagnosis by guided fine needle aspiration, a case report.
  • Renal oncocytomas are rare renal parenchymal neoplasms which have a good prognosis.
  • An accurate pre-operative diagnosis by guided fine needle aspiration cytology helps to plan a more conservative surgery.
  • Cytologic findings in a case of renal oncocytoma are presented.
  • The resected specimen showed the characteristic findings of oncocytoma.
  • Renal oncocytoma has to be distinguished from granular renal cell carcinoma (RCC) and chromophobe cell carcinoma, because of the markedly different prognosis.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / pathology. Kidney Neoplasms / diagnosis. Kidney Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy, Needle. Diagnosis, Differential. Female. Humans

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  • (PMID = 16758678.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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76. Sundararajan S, Dyer J, Pemberton R, Cohen RJ: Asymptomatic giant renal oncocytoma presenting with hypertension. Pathology; 2008 Dec;40(7):723-4
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  • [Title] Asymptomatic giant renal oncocytoma presenting with hypertension.
  • [MeSH-major] Adenoma, Oxyphilic / complications. Adenoma, Oxyphilic / pathology. Hypertension / etiology. Kidney Neoplasms / complications. Kidney Neoplasms / pathology
  • [MeSH-minor] Adult. Carcinoma, Renal Cell / pathology. Diagnosis, Differential. Humans. Male. Tomography, X-Ray Computed


77. Rowsell C, Fleshner N, Marrano P, Squire J, Evans A: Papillary renal cell carcinoma within a renal oncocytoma: case report of an incidental finding of a tumour within a tumour. J Clin Pathol; 2007 Apr;60(4):426-8
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  • [Title] Papillary renal cell carcinoma within a renal oncocytoma: case report of an incidental finding of a tumour within a tumour.
  • The most common renal tumours are clear cell, papillary, chromophobe and collecting duct renal cell carcinomas (RCCs), and benign oncocytomas and angiomyolipomas.
  • Tumours with hybrid features between some of these entities have been recognised; in particular, tumours with features of both chromophobe RCC and oncocytoma.
  • Case reports describing one distinct type of primary renal tumour actually within another are very rare.
  • The incidental finding of a papillary RCC located in an oncocytoma in a nephrectomy specimen from a 75-year-old man is described.
  • The cells in the papillary tumour contained three copies, whereas the oncocytoma cells contained only two per nucleus.
  • To our knowledge, this is the first report of a papillary RCC being identified within an oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Mixed Tumor, Malignant / pathology


78. Yamaguchi T, Kuroda N, Imamura Y, Hes O, Michal M, Sima R, Nakayama K, Sato N: Imprint cytologic features of chromophobe renal cell carcinoma morphologically resembling renal oncocytoma: is this an oncocytic variant of chromophobe renal cell carcinoma? Diagn Cytopathol; 2010 Jul;38(7):509-13
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  • [Title] Imprint cytologic features of chromophobe renal cell carcinoma morphologically resembling renal oncocytoma: is this an oncocytic variant of chromophobe renal cell carcinoma?
  • In this article, we report a case of 76-year-old woman with a rare variant of chromophobe renal cell carcinoma (CRCC).
  • Cytologically, renal tumor cells obtained from imprint cytology were isolated or arranged in small or monotonous population cells with abundant granular cytoplasm.
  • Immunocytochemically, the cytoplasm of almost all tumor cells was diffusely positive for vimentin and CK 7.
  • Additionally, tumor cells showed infiltration into some small renal veins covered by a single layer of endothelial cells.
  • These cytological and histological features entirely resembled those of renal oncocytoma.
  • As a result, we confirmed monosomy of chromosomes 7, 10, 13, and 17, and these findings corresponded to the diagnosis of CRCC.
  • Finally, we present a case of renal tumor morphologically resembling renal oncocytoma but genetically showing CRCC.
  • We suggest that oncocytic variant of CRCC may actually exist.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Renal Cell / pathology. Cytological Techniques / methods. Kidney / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Aged. Chromosomes, Human / genetics. Female. Humans. In Situ Hybridization, Fluorescence. Loss of Heterozygosity / genetics. Mutation / genetics. Von Hippel-Lindau Tumor Suppressor Protein / genetics


79. Fan YH, Chang YH, Huang WJ, Chung HJ, Chen KK: Renal oncocytoma: clinical experience of Taipei Veterans General Hospital. J Chin Med Assoc; 2008 May;71(5):254-8
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  • [Title] Renal oncocytoma: clinical experience of Taipei Veterans General Hospital.
  • BACKGROUND: Renal oncocytoma has been reported mostly in the Western literature, and only a few cases have been reported in Eastern populations.
  • In the present study, we review the clinical course of renal oncocytoma in our institution.
  • METHODS: We obtained the files of 13 cases of renal oncocytoma between 1988 and 2006 from the pathological archives of Taipei Veterans General Hospital.
  • RESULTS: The study population comprised 10 men and 3 women, and the mean age at diagnosis was 59.6 years (range, 37-75 years).
  • Twelve patients (92%) were asymptomatic at presentation and were incidentally diagnosed to have renal tumor by sonography (9 patients), computed tomography (1 patient) or magnetic resonance imaging (2 patients), and 1 presented with hematuria.
  • The clinical impression of oncocytoma was made preoperatively in only 3 patients by imaging studies, and most of the patients (76.9%) were diagnosed with renal cell carcinoma before surgery.
  • All patients had unilateral solitary renal tumor; the right kidney was involved in 7 cases (54%) and the left in 6 (46%).
  • Mean tumor size was 5.3 cm (range, 2.7-8.5 cm).
  • CONCLUSION: Renal oncocytoma has a benign clinical course with excellent long-term outcomes.
  • However, accurate preoperative diagnosis based only on imaging studies is difficult, and radical nephrectomy was performed for most of the patients in our series.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Kidney Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Carcinoma, Renal Cell / diagnosis. Female. Humans. Male. Middle Aged. Nephrectomy. Positron-Emission Tomography. Retrospective Studies

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  • (PMID = 18490230.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China (Republic : 1949- )
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80. Leroy X, Aubert S, Lemaitre L, Haffner J, Biserte J, Gosselin B: Multilocular cystic renal oncocytoma. J Clin Pathol; 2006 Feb;59(2):223-4
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  • [Title] Multilocular cystic renal oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Kidney Neoplasms / diagnosis

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81. Shriki J, Murthy V, Brown J: Renal oncocytoma on 1-11C acetate positron emission tomography: Case report and literature review. Mol Imaging Biol; 2006 Jul-Aug;8(4):208-11
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  • [Title] Renal oncocytoma on 1-11C acetate positron emission tomography: Case report and literature review.
  • Renal oncocytomas are uncommon tumors of the renal collecting duct.
  • Although generally benign, these tumors pose a diagnostic and therapeutic dilemma in that they can not be differentiated noninvasively from renal cell carcinomas.
  • The study demonstrated a nodule at the inferior pole of the right kidney with more uptake than the remainder of the kidney.
  • Upon resection, this nodule was determined to be an oncocytoma.
  • To our knowledge, this marks the first report of the 1-11C acetate PET scan appearance of a renal oncocytoma Possible mechanisms for increased uptake include dysfunctional, but up-regulated oxidative phosphorylation or uptake through lipid biosynthesis pathways.
  • [MeSH-major] Adenoma, Oxyphilic / diagnostic imaging. Kidney Neoplasms / diagnostic imaging. Positron-Emission Tomography

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  • (PMID = 16791747.001).
  • [ISSN] 1536-1632
  • [Journal-full-title] Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging
  • [ISO-abbreviation] Mol Imaging Biol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbon Radioisotopes
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82. Demirović A, Cesarec S, Spajić B, Tomas D, Bulimbasić S, Milosević M, Marusić Z, Kruslin B: Can renal oncocytoma be distinguished from chromophobe renal cell carcinoma by the presence of fibrous capsule? Virchows Arch; 2010 Jan;456(1):85-9
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  • [Title] Can renal oncocytoma be distinguished from chromophobe renal cell carcinoma by the presence of fibrous capsule?
  • The most important differential diagnosis of chromophobe renal cell carcinoma (CRCC) is renal oncocytoma.
  • Due to overlapping morphological characteristics of renal oncocytoma and CRCC, particularly its eosinophilic variant, making a correct diagnosis can be challenging.
  • To date, no data are available on the presence of the tumor fibrous capsule as a diagnostic feature in differentiating these tumors.
  • The main purpose of this study was to establish the presence and compare the thickness of the tumor fibrous capsule between two tumor groups.
  • A total of 37 tumors--18 cases of CRCC (three eosinophilic and 15 classic) and 19 cases of renal oncocytoma--were analyzed.
  • Four slides of each tumor stained with hematoxylin and eosin were first scanned at low-power magnification (x40) to assess the presence of the capsule.
  • The capsule was present in 12 (66.7%) cases of CRCCs and in only two (10.5%) cases of renal oncocytomas.
  • Statistical analysis showed significant difference between the presence of fibrous capsule in these two observed tumor groups (P = 0.001).
  • Average thickness of capsule in CRCCs was 337.7 microm, and 115.4 microm in renal oncocytomas, but the median was not statistically significant (P = 0.198).
  • Studies with a larger number of cases are needed to conclude if this characteristic could be a low-cost, reliable microscopic feature in differentiating between CRCC and renal oncocytoma.
  • [MeSH-major] Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / diagnosis. Kidney Neoplasms / pathology. Neoplasms, Glandular and Epithelial / diagnosis. Neoplasms, Glandular and Epithelial / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies


83. Krüger S, Sotlar K, Kausch I, Horny HP: Expression of KIT (CD117) in renal cell carcinoma and renal oncocytoma. Oncology; 2005;68(2-3):269-75
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  • [Title] Expression of KIT (CD117) in renal cell carcinoma and renal oncocytoma.
  • Our aim was to analyze KIT expression immunohistochemically in renal cell carcinomas (RCCs) and in oncocytomas.
  • METHODS: Routinely processed, paraffin-embedded specimens from 61 RCCs and 13 renal oncocytomas were investigated immunohistochemically.
  • Cytoplasmic and membrane-bound KIT staining of tumor cells was determined semiquantitatively.
  • Within the group of chromophobe RCCs, negative cytoplasmatic KIT reactivity was significantly correlated with advanced tumor stage (pT > or = 2; p = 0.036).
  • CONCLUSIONS: KIT expression is a hallmark of oncocytoma and chromophobe RCC.
  • [MeSH-major] Adenoma, Oxyphilic / chemistry. Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / chemistry. Kidney Neoplasms / chemistry. Proto-Oncogene Proteins c-kit / analysis
  • [MeSH-minor] Aged. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Neoplasm Staging

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  • [Copyright] Copyright (c) 2005 S. Karger AG, Basel.
  • (PMID = 16015044.001).
  • [ISSN] 0030-2414
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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84. Yoost TR, Clarke HS, Savage SJ: Laparoscopic cryoablation of renal masses: which lesions fail? Urology; 2010 Feb;75(2):311-4
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  • [Title] Laparoscopic cryoablation of renal masses: which lesions fail?
  • OBJECTIVE: To identify potential predictive characteristics of lesions which failed in laparoscopic renal cryoablation (LRC).
  • METHODS: We reviewed 45 consecutive patients who underwent LRC of a renal mass between 2003 and 2008 at a single institution.
  • We analyzed patient age, ASA, pre- and postoperative creatinine, tumor size, location, number of cryoprobes used, and histology of the lesions.
  • Of the biopsy samples from 40 of 47 lesions, renal cell carcinoma was found in 23, oncocytoma was found in 7, and 10 were benign or inconclusive.
  • Treatment failure was noted in 8 of 47 lesions (17%), 7 of which (87.5% of failed lesions) had broad-based contact with the renal sinus.
  • Broad-based lesions which made contact with the renal sinus were successfully treated 53.3% of the time, whereas lesions which lacked contact with the renal sinus were treated successfully 96.9% of the time (P <.01).
  • CONCLUSIONS: Broad-based central location of a renal mass may predict a significantly increased risk of failure of LRC and should be considered in patient counseling.
  • [MeSH-major] Cryosurgery / methods. Kidney Neoplasms / surgery. Laparoscopy

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  • [Copyright] Published by Elsevier Inc.
  • (PMID = 20018355.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Schmidt LS, Nickerson ML, Warren MB, Glenn GM, Toro JR, Merino MJ, Turner ML, Choyke PL, Sharma N, Peterson J, Morrison P, Maher ER, Walther MM, Zbar B, Linehan WM: Germline BHD-mutation spectrum and phenotype analysis of a large cohort of families with Birt-Hogg-Dubé syndrome. Am J Hum Genet; 2005 Jun;76(6):1023-33
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  • Birt-Hogg-Dubé syndrome (BHD), a genodermatosis characterized by multiple hamartomas of the hair follicle (fibrofolliculoma), predisposes individuals to an increased risk of developing renal neoplasms and spontaneous pneumothorax.
  • Among patients with a mutation in the exon 11 hotspot, significantly fewer renal tumors were observed in patients with the C-deletion than those with the C-insertion mutation.
  • Of the 53 families with BHD whose members inherited either a germline mutation or the affected haplotype, 24 (45%) had at least one member with renal neoplasms.
  • Three families classified with familial renal oncocytoma were identified with BHD mutations, which represents the first disease gene associated with this rare form of renal neoplasm.

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  • (PMID = 15852235.001).
  • [ISSN] 0002-9297
  • [Journal-full-title] American journal of human genetics
  • [ISO-abbreviation] Am. J. Hum. Genet.
  • [Language] ENG
  • [Databank-accession-numbers] OMIM/ 135150
  • [Grant] United States / PHS HHS / / N01-C0-12400
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / FLCN protein, human; 0 / Proteins; 0 / Proto-Oncogene Proteins; 0 / Tumor Suppressor Proteins
  • [Other-IDs] NLM/ PMC1196440
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86. Argüelles Salido E, Marcilla Plaza D, Medina López R, Congregado Ruiz B, Campoy Martínez P, Cayuela Domínguez A: [Renal oncocytoma. Review of our 22 patients]. Actas Urol Esp; 2006 Jun;30(6):583-90
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  • [Title] [Renal oncocytoma. Review of our 22 patients].
  • [Transliterated title] Oncocitoma renal. Revisión de nuestra serie de 22 pacientes.
  • Renal oncocytoma (OR) is a benign tumor.
  • It may represent up to 3-7% of solid kidney masses, and shows specifics cellular and evolutive characteristics.
  • MATERIALS AND METHODS: Between 1986 and 2005, 478 kidney tumors have been surgically treated at our institution.
  • We report the frequency and characteristics of OR in our patients, compared with renal cell carcinomas (RCC).
  • We try to find out the rate of multifocality, bilateralism and other tumor association, and the number of neoplasms originally diagnosed as OR before surgery.
  • 12 in the left kidney and 12 in the right one, one patient presenting oncocytomatosis.
  • Tumor mean size was 4.64 cm (1-12.5 cm).
  • CONCLUSIONS: The rate of OR found in our sample population of renal tumors undergoing surgery matches other series already published.
  • All cases presented a benign evolution.
  • [MeSH-major] Adenoma, Oxyphilic. Kidney Neoplasms

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  • (PMID = 16921835.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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87. Huang W, Kanehira K, Drew S, Pier T: Oncocytoma can be differentiated from its renal cell carcinoma mimics by a panel of markers: an automated tissue microarray study. Appl Immunohistochem Mol Morphol; 2009 Jan;17(1):12-7
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  • [Title] Oncocytoma can be differentiated from its renal cell carcinoma mimics by a panel of markers: an automated tissue microarray study.
  • BACKGROUND: Differentiating oncocytoma from its renal cell carcinoma (RCC) mimics, particularly chromophobe RCC, can be difficult, especially when limited tissue is available for evaluation.
  • This study presents a panel of markers that are readily available, easy to use, and useful for differential diagnoses of renal tumors.
  • DESIGN: A renal cell neoplasm tissue microarray was constructed including oncocytoma (n=30), chromophobe RCC (n=18), conventional RCC (n=64), papillary RCC (n=50), and benign renal tissues (n=31).
  • CK7, CD10, epithelial membrane antigen, renal cell carcinoma marker (RCCma), vimentin, and endogenous avidin-binding activity (EABA) were studied.
  • RESULT: EABA was positive in 97% of oncocytoma, 26% of conventional RCC and 35% of papillary RCC with granular/eosinophilic (G/E) features and 6% of chromophobe RCC.
  • Vimentin and RCCma were positive in most RCC with G/E features (conventional, 78% and 71%; and papillary, 85% and 76%, respectively), and negative in oncocytoma.
  • CK7 was positive in up to 81% of papillary RCC and 63% of chromophobe RCC, and essentially negative in conventional RCC and oncocytoma.
  • CONCLUSIONS: EABA is an excellent marker for oncocytoma, which can be useful in differentiating oncocytoma from chromophobe RCC.
  • A panel of EABA, vimentin, and RCCma markers can be useful in discerning oncocytoma from RCC with G/E features.

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  • (PMID = 18769342.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Vimentin; EC 2.7.11.22 / MOK protein, human; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
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88. Al-Saleem T, Balsara BR, Liu Z, Feder M, Testa JR, Wu H, Greenberg RE: Renal oncocytoma with loss of chromosomes Y and 1 evolving to papillary carcinoma in connection with gain of chromosome 7. Coincidence or progression? Cancer Genet Cytogenet; 2005 Nov;163(1):81-5
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  • [Title] Renal oncocytoma with loss of chromosomes Y and 1 evolving to papillary carcinoma in connection with gain of chromosome 7. Coincidence or progression?
  • Hybrid tumors of the kidney are not rare.
  • Previous studies of hybrid renal tumors have been valuable for the understanding of the pathogenesis and progression pathways of renal cell neoplasm.
  • In this paper we describe the morphologic, immunohistochemical, and genetic features of 2 oncocytomas with evolving papillary renal cell carcinoma (PRCC) in a nephrectomy specimen of a 60-year old male.
  • The patient was referred for urologic oncology consultation after the incidental discovery of a renal tumor.
  • Papillary carcinoma nests were highlighted with cytokeratin 7 and vimentin positivity and were more prominent in the larger tumor.
  • We postulate that the PRCC represents a neoplastic progression by the gain of chromosome 7 oncocytoma with -Y and -1.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Carcinoma, Papillary / genetics. Chromosome Aberrations. Chromosome Deletion. Chromosomes, Human, Pair 7. Chromosomes, Human, Y. Kidney Neoplasms / genetics

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  • (PMID = 16271962.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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89. Hes O, Michal M: Images in pathology. "Digital'' lung metastasis of a renal oncocytoma. Int J Surg Pathol; 2005 Jul;13(3):280
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  • [Title] Images in pathology. "Digital'' lung metastasis of a renal oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / secondary. Artifacts. Kidney Neoplasms / pathology. Lung / pathology. Lung Neoplasms / secondary. Photomicrography / methods

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  • [CommentIn] Int J Surg Pathol. 2006 Jan;14(1):107 [16501847.001]
  • (PMID = 16086085.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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90. Alvarez Ardura M, Hernández Cañas V, de la Morena Gallego JM, Rengifo Abbad D, González-Chamorro Ladrón de Guevara F, Llorente Abarca C: [Giant renal oncocytoma]. Actas Urol Esp; 2005 Sep;29(8):791-3
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  • [Title] [Giant renal oncocytoma].
  • [Transliterated title] Oncocitoma renal gigante.
  • Renal oncocytoma is a benign neoplasms arising from cells of the distal renal tubule.
  • They acount for 3-7% of all renal tumors. most are incidental findings.
  • Differential diagnosis with renal cells carcinoma is often difficult.
  • Here we report a case of big renal oncocytoma as an incidental finding while performing an abdominal ultrasound in a patient with low abdominal pain.
  • [MeSH-major] Adenoma, Oxyphilic / diagnostic imaging. Kidney Neoplasms / diagnostic imaging

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  • (PMID = 16304913.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas espanolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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91. Fujii Y, Komai Y, Saito K, Iimura Y, Yonese J, Kawakami S, Ishikawa Y, Kumagai J, Kihara K, Fukui I: Incidence of benign pathologic lesions at partial nephrectomy for presumed RCC renal masses: Japanese dual-center experience with 176 consecutive patients. Urology; 2008 Sep;72(3):598-602
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  • [Title] Incidence of benign pathologic lesions at partial nephrectomy for presumed RCC renal masses: Japanese dual-center experience with 176 consecutive patients.
  • OBJECTIVES: To determine the incidence of benign pathologic findings at elective partial nephrectomy for renal masses thought to be renal cell carcinoma (RCC) on preoperative imaging in Japanese patients.
  • Overall, 97 and 79 patients had a renal mass of < or = 2 cm and > 2 cm, respectively.
  • RESULTS: Of the 176 masses resected, the pathologic examination revealed benign findings in 19 (11%), angiomyolipoma in 10 (5.7%), oncocytoma in 5 (2.8%), complicated cysts in 2 (1.1%), and a solitary fibrous tumor and scar of the kidney 1 each (0.6%).
  • Of the 46 women, 12 (26.1%) had benign lesions compared with 7 of the 130 men (5.3%; P = .0003).
  • Tumor size was not associated with benign histologic findings.
  • The incidence of benign lesions was equivalent (10% and 12%) between the 2 centers.
  • CONCLUSIONS: The present incidence (11%) of benign lesions in presumed RCC masses at surgery in Japanese patients was lower than the incidence of 20%-30% previously reported from Western countries, probably because of the low incidence of oncocytomas in Japanese patients.
  • Women had almost 5 times the likelihood of having a benign lesion compared with men, because of the high incidence of angiomyolipomas in women.
  • [MeSH-major] Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / epidemiology. Kidney Neoplasms / diagnosis. Kidney Neoplasms / epidemiology. Nephrectomy / methods
  • [MeSH-minor] Aged. Female. Humans. Incidence. Japan. Kidney / surgery. Magnetic Resonance Imaging / methods. Male. Middle Aged. Tomography, X-Ray Computed / methods. Treatment Outcome. Ultrasonography / methods

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  • (PMID = 18649929.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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92. Ibarz Servio L, Ruiz Domínguez J, Cannata Ortiz P, Olazábal Zudaire A: [Giant renal oncocytoma]. Med Clin (Barc); 2009 Apr 11;132(13):527
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  • [Title] [Giant renal oncocytoma].
  • [Transliterated title] Oncocitoma renal gigante.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Kidney Neoplasms / pathology

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  • (PMID = 19232648.001).
  • [ISSN] 0025-7753
  • [Journal-full-title] Medicina clínica
  • [ISO-abbreviation] Med Clin (Barc)
  • [Language] spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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93. Neuzillet Y, Lechevallier E: [Renal oncocytoma]. Prog Urol; 2006 Apr;16(2):105-11
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  • [Title] [Renal oncocytoma].
  • Due to its nonspecific clinical and radiological features, renal oncocytoma is usually diagnosed on the operative specimen.
  • Histological confirmation of the diagnosis is based on the distinction between oncocytoma and renal cell carcinoma (RCC), which can be difficult.
  • Description of cases in which RCC and oncocytoma are present in the same tumour and the hypothesis of a link between oncocytoma and RCC further complicate the diagnosis of this tumour by the urologist.
  • The authors reviewed the management of tumours suspected to be oncocytoma based on a review of the international literature concerning the diagnosis, natural history and treatment of renal oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic. Kidney Neoplasms

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  • (PMID = 16734229.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 88
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94. Breda A, Treat EG, Haft-Candell L, Leppert JT, Harper JD, Said J, Raman S, Smith RB, Belldegrun AS, Schulam PG: Comparison of accuracy of 14-, 18- and 20-G needles in ex-vivo renal mass biopsy: a prospective, blinded study. BJU Int; 2010 Apr;105(7):940-5
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  • [Title] Comparison of accuracy of 14-, 18- and 20-G needles in ex-vivo renal mass biopsy: a prospective, blinded study.
  • OBJECTIVE: To prospectively determine the accuracy of 14-, 18- and 20-G core needle biopsies to render the appropriate histological diagnosis of solid, enhancing renal masses, using a controlled, ex-vivo biopsy technique.
  • RESULTS: The final pathological evaluation classified 21 masses (68%) as clear cell renal cell carcinoma (RCC), three (10%) as papillary RCC, three (10%) as chromophobe RCC, three (10%) as oncocytoma and one (3%) as a benign lymphoid infiltrate.
  • In two cases chromophobe RCC was misdiagnosed with oncocytoma, and vice versa.
  • CONCLUSION: In this study a minimum of an 18-G biopsy needle was the most accurate in determining the histological diagnosis.
  • Clear cell and papillary RCCs were accurately diagnosed on biopsy using an 18-G, whereas oncocytoma and chromophobe RCC were difficult to differentiate using standard H&E techniques and immunohistochemistry.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Biopsy, Needle / standards. Carcinoma, Papillary / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Nephrectomy / methods

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  • (PMID = 19888984.001).
  • [ISSN] 1464-410X
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] England
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95. Tan MH, Wong CF, Tan HL, Yang XJ, Ditlev J, Matsuda D, Khoo SK, Sugimura J, Fujioka T, Furge KA, Kort E, Giraud S, Ferlicot S, Vielh P, Amsellem-Ouazana D, Debré B, Flam T, Thiounn N, Zerbib M, Benoît G, Droupy S, Molinié V, Vieillefond A, Tan PH, Richard S, Teh BT: Genomic expression and single-nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and oncocytoma. BMC Cancer; 2010;10:196
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  • [Title] Genomic expression and single-nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and oncocytoma.
  • BACKGROUND: Chromophobe renal cell carcinoma (chRCC) and renal oncocytoma are two distinct but closely related entities with strong morphologic and genetic similarities.
  • While chRCC is a malignant tumor, oncocytoma is usually regarded as a benign entity.
  • The overlapping characteristics are best explained by a common cellular origin, and the biologic differences between chRCC and oncocytoma are therefore of considerable interest in terms of carcinogenesis, diagnosis and clinical management.
  • Previous studies have been relatively limited in terms of examining the differences between oncocytoma and chromophobe RCC.
  • METHODS: Gene expression profiling using the Affymetrix HGU133Plus2 platform was applied on chRCC (n = 15) and oncocytoma specimens (n = 15).
  • CONCLUSIONS: Gene expression profiles, high-throughput SNP genotyping, and pathway analysis effectively distinguish chRCC from oncocytoma.
  • A cytogenetic alteration, loss of chromosome 1p, common to renal oncocytoma and chRCC has been identified, providing the opportunities for identifying novel tumor suppressor genes and we have identified a series of immunohistochemical markers that are clinically useful in discriminating chRCC and oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Biomarkers, Tumor / genetics. Carcinoma, Renal Cell / genetics. Chromosomes, Human, Pair 1. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Genetic Testing / methods. Kidney Neoplasms / genetics. Polymorphism, Single Nucleotide
  • [MeSH-minor] Aquaporin 6 / analysis. Cytogenetic Analysis. Diagnosis, Differential. Gene Dosage. Gene Regulatory Networks. Humans. Immunohistochemistry. Membrane Proteins / analysis. Nerve Tissue Proteins / analysis. Odds Ratio. Oligonucleotide Array Sequence Analysis. Predictive Value of Tests. Reproducibility of Results. Synaptogyrins. Tumor Suppressor Proteins / analysis


96. Feng G, Li G, Gentil-Perret A, Tostain J, Genin C: Elevated serum-circulating RNA in patients with conventional renal cell cancer. Anticancer Res; 2008 Jan-Feb;28(1A):321-6
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  • [Title] Elevated serum-circulating RNA in patients with conventional renal cell cancer.
  • BACKGROUND: Reliable serum biomarkers for differential diagnosis of conventional renal cell carcinoma (RCC) are highly desirable.
  • The purpose of our study was to evaluate whether the amounts of circulating RNA could discriminate between conventional renal cancer patients and healthy individuals as a tumor marker.
  • PATIENTS AND METHODS: A total of 71 patients with conventional RCC, 12 with renal oncocytomas and 44 healthy individuals entered into this study.
  • RESULTS: The mean level of RNA in conventional RCC (1414.19 +/- 91.95 ng/ml) was significantly higher than that in healthy individuals (520.49 +/- 39.75 ng/ml, p<0.0001) and these with renal oncocytomas (560.71 +/- 69.54 ng/ml, p<0.0001).
  • Among the conventional RCC, there was no significant difference in circulating RNA levels in terms of tumor stage, grade or size.
  • The area under the ROC curve was 0.956 (95% confidence interval, 0.923 to 0.989), indicating an acceptable sensitivity and specificity as a tumor marker.
  • CONCLUSION: The data suggest that elevated circulating RNA may be a valuable diagnostic tool for discriminating conventional RCC patients from normal individuals or from these with renal oncocytoma.
  • Elevated serum circulating RNA provides a new research area as biomarker for the diagnosis of conventional RCC.
  • [MeSH-major] Carcinoma, Renal Cell / blood. Kidney Neoplasms / blood. RNA, Neoplasm / blood
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / blood. Female. Humans. Male. Middle Aged. ROC Curve. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 18383864.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Neoplasm
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97. Henderson A, Douglas F, Perros P, Morgan C, Maher ER: SDHB-associated renal oncocytoma suggests a broadening of the renal phenotype in hereditary paragangliomatosis. Fam Cancer; 2009;8(3):257-60
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  • [Title] SDHB-associated renal oncocytoma suggests a broadening of the renal phenotype in hereditary paragangliomatosis.
  • Renal tumours are also increasingly being reported as component tumours in hereditary paragangliomatosis associated with mutations in SDHB.
  • We present the first reported case of a family in whom an individual shown to carry a mutation in SDHB developed a renal oncocytoma.
  • We review other reports of renal tumours associated with SDHB-associated hereditary paragangliomatosis and suggest that various histological subtypes of renal tumours are part of this condition.
  • This observation indicates that SDHB-associated hereditary paragangliomatosis is unlike most tumour predisposition syndromes associated with the development of renal tumours which are usually associated with specific histological sub-types.
  • The increasing recognition of the involvement of renal tumours in SDHB mutation carriers suggests that renal screening is likely to be valuable for these patients.
  • SDHB mutations should also be considered in the context of genetic testing when renal tumours, regardless of histopathology, present in families with other tumours consistent hereditary paraganglioma syndrome.
  • [MeSH-minor] Aged. Case-Control Studies. DNA Mutational Analysis. Female. Genetic Predisposition to Disease. Genotype. Head and Neck Neoplasms / genetics. Humans. Kidney Neoplasms / genetics. Male. Pedigree. Phenotype. Retroperitoneal Neoplasms / genetics. Thyroid Neoplasms / genetics

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  • (PMID = 19184535.001).
  • [ISSN] 1573-7292
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Iron-Sulfur Proteins
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98. Hes O, Michal M, Kuroda N, Martignoni G, Brunelli M, Lu Y, Adley BP, Alvarado-Cabrero I, Yang XJ: Vimentin reactivity in renal oncocytoma: immunohistochemical study of 234 cases. Arch Pathol Lab Med; 2007 Dec;131(12):1782-8
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  • [Title] Vimentin reactivity in renal oncocytoma: immunohistochemical study of 234 cases.
  • CONTEXT: The expression of vimentin in benign renal oncocytomas has been controversial.
  • However, this is of clinical significance because immunostains may be used in differential diagnosis of renal tumors on limited biopsy specimens.
  • Using different staining and analysis methods, we studied vimentin immunoreactivity in a large series of renal oncocytomas with a special emphasis on the immunoreactivity patterns.
  • OBJECTIVE: Immunohistochemical expression of vimentin has been used in the differential diagnosis of renal epithelial neoplasms.
  • Although typically expressed in most renal cell carcinomas, the immunoreactivity of this intermediate filament in renal oncocytomas has been controversial.
  • DESIGN: We studied vimentin immunoreactivity in a large series of 234 renal oncocytomas using 2 staining methods as well as manual and automated imaging analyses.
  • RESULTS: We found that the focal vimentin immunoreactivity can be seen in most (72.6%) renal oncocytomas with vimentin-positive tumor cells usually found in the edge of a central scar or in small clusters scattered throughout the tumor.
  • Computer-aided imaging analysis using ChromaVision Automatic Cellular Imaging System II confirmed the difference in vimentin immunoreactivity between oncocytoma and other renal neoplasms.
  • CONCLUSIONS: Our study of vimentin immunohistochemistry in a series of renal oncocytomas, which to our knowledge is the largest ever published, showed focal vimentin positivity detected in most oncocytomas.
  • Because the vimentin staining patterns in renal oncocytomas are different from those seen in clear cell or papillary renal cell carcinomas, we consider vimentin staining to be helpful in the differential diagnosis of oncocytoma from other renal tumor mimics.
  • Furthermore, strong vimentin positivity in a renal cell neoplasm does not exclude the diagnosis of renal oncocytoma, particularly in a limited biopsy specimen.
  • [MeSH-major] Adenoma, Oxyphilic / metabolism. Kidney Neoplasms / metabolism. Vimentin / biosynthesis
  • [MeSH-minor] Diagnosis, Differential. Humans. Image Processing, Computer-Assisted. Immunohistochemistry

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  • (PMID = 18081436.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vimentin
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99. Gasparre G, Hervouet E, de Laplanche E, Demont J, Pennisi LF, Colombel M, Mège-Lechevallier F, Scoazec JY, Bonora E, Smeets R, Smeitink J, Lazar V, Lespinasse J, Giraud S, Godinot C, Romeo G, Simonnet H: Clonal expansion of mutated mitochondrial DNA is associated with tumor formation and complex I deficiency in the benign renal oncocytoma. Hum Mol Genet; 2008 Apr 1;17(7):986-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clonal expansion of mutated mitochondrial DNA is associated with tumor formation and complex I deficiency in the benign renal oncocytoma.
  • Here we show a benign tumor type in which mtDNA mutations that lead to complex I (CI) enzyme deficiency are found in all tumors and are the only genetic alteration detected.
  • Actually renal oncocytomas are homogeneous tumors characterized by dense accumulation of mitochondria and we had found that they are deficient in electron transport chain complex I (CI, NADH-ubiquinone oxidoreductase).
  • [MeSH-major] Adenoma, Oxyphilic / genetics. DNA, Mitochondrial / genetics. Electron Transport Complex I / genetics. Kidney Neoplasms / genetics

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  • (PMID = 18156159.001).
  • [ISSN] 1460-2083
  • [Journal-full-title] Human molecular genetics
  • [ISO-abbreviation] Hum. Mol. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Mitochondrial; 0 / Electron Transport Chain Complex Proteins; 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / RNA, Messenger; EC 1.6.5.3 / Electron Transport Complex I; EC 1.6.99.3 / NADH Dehydrogenase; EC 2.3.3.1 / Citrate (si)-Synthase; EC 2.7.7.- / POLG protein, human; EC 2.7.7.7 / DNA-Directed DNA Polymerase; IY9XDZ35W2 / Glucose
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100. Eiss D, Larousserie F, Mejean A, Ghouadni M, Merran S, Correas JM, Hélénon O: [Renal oncocytoma: CT diagnostic criteria revisited]. J Radiol; 2005 Dec;86(12 Pt 1):1773-82
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  • [Title] [Renal oncocytoma: CT diagnostic criteria revisited].
  • PURPOSE: To redefine and evaluate the computed tomographic criteria for the diagnosis of renal oncocytoma (RO) for which renal sparing surgery should be preferred.
  • A double blinded comparative study was made of 60 renal tumors (containing adenocarcinomas and oncocytomas) larger than 3 cm in diameter in order to evaluate the redefined CT diagnostic criteria.
  • RESULTS: Among RO larger than 3 cm in diameter, 55% presented a sharply defined low attenuation scar on post-contrast scans at the tubular nephrographic phase, central or eccentric, with homogeneous attenuation throughout the remainder of the hypervascular tumor which was classified in 3 different groups.
  • The use of our CT diagnostic criteria gave a statistically significant (p < 0.05) Kappa index of inter-observer concordance of 0.71 and a specificity of 96% for the diagnosis of RO.
  • CONCLUSION: Our redefined computed tomographic criteria for the diagnosis of renal oncocytoma, eventually associated with renal biopsy, should increase the indications for renal sparing surgery for RO larger than 3 cm in diameter.
  • [MeSH-major] Adenoma, Oxyphilic / radiography. Kidney Diseases / radiography. Tomography, X-Ray Computed






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