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1. Sterker I, Hagert-Winkler A, Gradistanac T, Frerich B: [Granular cell tumor of the orbit]. Ophthalmologe; 2007 Sep;104(9):803-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Granular cell tumor of the orbit].
  • Granular cell tumor (GCT, Abrikossoff tumor) is an extremely rare, benign tumor with a neurogenic origin occurring most commonly in the upper aerodigestive tract.
  • We report on a 26 year old man suffering from unilateral ocular hypertension and retrobulbar pain.
  • [MeSH-major] Granular Cell Tumor. Orbital Neoplasms

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  • (PMID = 17440732.001).
  • [ISSN] 0941-293X
  • [Journal-full-title] Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • [ISO-abbreviation] Ophthalmologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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2. Arora R, Monga S, Mehta DK, Raina UK, Gogi A, Gupta SD: Malignant fibrous histiocytoma of the conjunctiva. Clin Exp Ophthalmol; 2006 Apr;34(3):275-8
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  • They can occur in any part of the body including the orbital tissues.
  • Eleven of these were classified as benign, and the rest were malignant fibrous histiocytomas.
  • Benign fibrous histiocytomas have been reported in the orbit, eyelid, episclera and conjunctiva.
  • Malignant fibrous histiocytoma has been well described in the orbit, but rarely as a primary conjunctival tumour.
  • The rarity of the tumour makes its diagnosis and management a challenge.
  • Herein, the clinicopathological features of a case of malignant fibrous histiocytoma are presented and its management with wide excision and cryotherapy followed by ocular reconstruction with amniotic membrane transplant is discussed.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Histiocytoma, Malignant Fibrous / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Humans. Male. Middle Aged. Neoplasm Proteins / metabolism

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  • (PMID = 16671910.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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3. Archondakis S, Skagias L, Tsakiris A, Sambaziotis D, Daskalopoulou D: Oncocytoma of the lacrimal gland diagnosed initially by fine-needle aspiration cytology. Diagn Cytopathol; 2009 Jun;37(6):443-5
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  • Oncocytomas are benign tumors that infrequently involve ocular adnexa.
  • An 83-year-old patient presented to the cytology laboratory with a peripunctal mass in the right eye.
  • The tumor was aspirated.
  • The cytoplasm of the tumor cells was rich in eosinophilic granules.
  • The initial cytological diagnosis was oncocytoma.
  • The tumor was then completely excised and the histological diagnosis confirmed the initial cytological one.
  • Oncocytoma is a rare entity which must be considered in differential diagnosis of a peripunctal mass in elderly patients.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / pathology. Lacrimal Apparatus / pathology

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19217061.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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4. Tomita M, Goto H, Muramatsu R, Usui M: Treatment of large conjunctival nevus by resection and reconstruction using amniotic membrane. Graefes Arch Clin Exp Ophthalmol; 2006 Jun;244(6):761-4
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  • BACKGROUND: Nevus of the bulbar conjunctiva is a benign pigmented lesion of the ocular surface.
  • METHODS: A 54-year-old Japanese man was referred to our clinic with suspected malignant tumor of the bulbar conjunctiva in his right eye.
  • A large and diffuse pigmented tumor with numerous small cysts was present mainly on the upper bulbar conjunctiva.
  • Resection of the conjunctival tumor and amniotic membrane transplantation for reconstruction of the bulbar conjunctiva were performed.
  • RESULTS: The histopathological diagnosis was conjunctival nevus.
  • [MeSH-major] Amnion / transplantation. Conjunctival Neoplasms / surgery. Nevus, Pigmented / surgery. Ophthalmologic Surgical Procedures

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  • (PMID = 16315045.001).
  • [ISSN] 0721-832X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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5. Kaliaperumal S, Gupta A, Nongrum B, Rao VA, Srinivasan R: Case reports of three patients showing optic nerve head melanocytoma and systemic hypertension. Ophthalmologica; 2007;221(1):62-4
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  • CASES: Ocular examination of 3 asymptomatic hypertensive patients revealed a pigmented lesion over the optic disk.
  • After clinical examination and radiological evaluation a diagnosis of optic disk melanocytoma was made.
  • CONCLUSIONS: Optic disk melanocytoma is a benign tumor though the lesion may increase in size with the resultant decrease in visual acuity over few years.
  • [MeSH-major] Hypertension / complications. Nevus, Pigmented / etiology. Optic Disk / pathology. Optic Nerve Neoplasms / etiology

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  • [Copyright] Copyright 2007 S. Karger AG, Basel.
  • (PMID = 17183204.001).
  • [ISSN] 0030-3755
  • [Journal-full-title] Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
  • [ISO-abbreviation] Ophthalmologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 55-10-7 / Vanilmandelic Acid
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6. Al-Rashaed S, Abboud EB, Nowilaty SR: Characteristics of optic disc melanocytomas presenting with visual dysfunction. Middle East Afr J Ophthalmol; 2010 Jul;17(3):242-5
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  • OBJECTIVE AND DESIGN: A retrospective review study was designed to describe five cases of optic disc melanocytomas with tumor-related visual impairment.
  • PARTICIPANTS: Five patients with optic disc melanocytoma presented with visual complaints to a tertiary eye hospital in Saudi Arabia.
  • MATERIALS AND METHODS: Demographic and clinical data were analyzed, including the results of ocular examination, lesion laterality, best-corrected Snellen visual acuity, pupillary reflex, visual field testing, color fundus photography, fundus fluorescein angiography, and ophthalmic ultrasound.
  • Case 1 had macular star edema with mild tumor enlargement, Case 2 had optic atrophy, Case 3 had juxtapapillary choroidal neovascular membrane with macular involvement, Case 4 had optic disc swelling with an enlarged blind spot, and Case 5 had a large altitudinal visual field defect.
  • CONCLUSION: Although melanocytomas of the optic disc tend to have a benign behavior with slow evolution and stable vision, they may adversely affect visual function through a variety of mechanisms.

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  • (PMID = 20844679.001).
  • [ISSN] 0975-1599
  • [Journal-full-title] Middle East African journal of ophthalmology
  • [ISO-abbreviation] Middle East Afr J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2934715
  • [Keywords] NOTNLM ; Melanocytoma / Optic Disc / Visual Function
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7. Smith JH, Padnick-Silver L, Newlin A, Rhodes K, Rubinstein WS: Genetic study of familial uveal melanoma: association of uveal and cutaneous melanoma with cutaneous and ocular nevi. Ophthalmology; 2007 Apr;114(4):774-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetic study of familial uveal melanoma: association of uveal and cutaneous melanoma with cutaneous and ocular nevi.
  • METHODS: Evaluation of a large sibship via family history, complete eye and skin examinations, environmental risk factor questionnaire, and genetic testing, as well as a MEDLINE search of familial uveal melanoma kindreds.
  • MAIN OUTCOME MEASURES: Cutaneous and ocular nevi, benign and malignant neoplasms of skin and other sites, brief skin cancer risk assessment tool risk classification for cutaneous melanoma, DNA sequencing of p16INK4a and p14ARF genes, and citations on familial uveal melanoma.
  • No germline mutations were detected in the melanoma-associated tumor suppressor genes p16INK4a and p14ARF.
  • Seven out of 10 siblings had a history of cutaneous and/or ocular nevi.
  • Of the 3 subjects without nevi, 2 had histories of eye or skin malignancies (1 uveal melanoma, 1 basal cell carcinoma).
  • Three of the 10 siblings had relevant ocular findings (2 choroidal nevi, 1 uveal melanoma).
  • [MeSH-major] Carcinoma, Basal Cell / genetics. Melanoma / genetics. Nevus, Pigmented / genetics. Skin Neoplasms / genetics. Uveal Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cyclin-Dependent Kinase Inhibitor p16 / genetics. DNA, Neoplasm / analysis. Female. Humans. Male. Middle Aged. Pedigree. Risk Factors. Sequence Analysis, DNA. Surveys and Questionnaires. Tumor Suppressor Protein p14ARF / genetics


8. Finn M, Krohne S, Stiles J: Ocular melanocytic neoplasia. Compend Contin Educ Vet; 2008 Jan;30(1):19-25; quiz 26
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ocular melanocytic neoplasia.
  • Tumors of melanocytic origin in ocular tissues are relatively uncommon in dogs and cats, and although many are benign, some have a high potential for metastasis.
  • In addition, even small ocular masses can be significant due to their potential vision-threatening sequelae.
  • While several similarities exist among these tumors, the prognosis and recommended treatment options vary based on the species affected as well as the location, extent, and histologic characteristics of the tumor.
  • [MeSH-major] Cat Diseases / diagnosis. Dog Diseases / diagnosis. Eye Neoplasms / veterinary. Melanoma / veterinary

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  • (PMID = 18278744.001).
  • [ISSN] 1940-8315
  • [Journal-full-title] Compendium (Yardley, PA)
  • [ISO-abbreviation] Compend Contin Educ Vet
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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9. Ferlito A, Elsheikh MN, Manni JJ, Rinaldo A: Paraneoplastic syndromes in patients with primary head and neck cancer. Eur Arch Otorhinolaryngol; 2007 Mar;264(3):211-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Paraneoplastic syndromes represent the clinical manifestations of the indirect and remote effects produced by tumor metabolites or other products.
  • Paraneoplastic syndromes related to primary malignancies of the head and neck region can be categorized as: endocrine, cutaneous or dermatologic, hematologic, neurologic, osteoarticular or rheumatologic, ocular syndromes.
  • Sometimes, paraneoplastic syndromes can be more serious than the consequences of the primary tumor itself and can precede, follow or be concurrent to the diagnosis of a malignancy; moreover, they can dominate the clinical picture and thus lead to errors with respect to the origin and type of the primary tumor.
  • Physicians who deal with cancer-associated syndromes should be able to differentiate the paraneoplastic syndromes from the benign disorders that mimic them.
  • Patients with a suspected paraneoplastic disorder should undergo a complete panel of laboratory studies, in addition to imaging studies and endoscopy.
  • Identification of paraneoplastic syndromes allow the clinician to make an early diagnosis and to provide adequate treatment of tumors, with a favorable oncologic outcome and improved life expectancy for the patient.
  • These syndromes can follow the clinical course of the tumor and thus be useful for monitoring its evolution.
  • [MeSH-major] Chorionic Gonadotropin, beta Subunit, Human / metabolism. Head and Neck Neoplasms. Paraneoplastic Syndromes

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  • (PMID = 17206403.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human
  • [Number-of-references] 126
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10. Fernandes BF, Castiglione E, Belfort RN, Codère F, Burnier MN Jr: Orbital leiomyoma: histopathologic and immunohistochemical findings of a rare tumor. Ophthal Plast Reconstr Surg; 2009 Jan-Feb;25(1):59-61
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  • [Title] Orbital leiomyoma: histopathologic and immunohistochemical findings of a rare tumor.
  • The tumor did not compromise other orbital structures.
  • On the basis of the histopathologic and immunohistochemical findings, the diagnosis of orbital leiomyoma was established.
  • Orbital leiomyoma is a slow-growing tumor that can be located anywhere in the orbit.
  • Although there are no unique features that help the radiologist to exclude other benign lesions of the orbit, the histopathologic diagnosis using immunohistochemical markers is usually straightforward.
  • Attention to the cytologic features that exclude the malignant variant is of utmost relevance for proper diagnosis and patient counseling.
  • [MeSH-major] Leiomyoma / pathology. Orbital Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Humans. Immunoenzyme Techniques. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 19273932.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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11. Ishijima K, Kase S, Noda M, Ishida S: [Pyogenic granuloma developing rapidly after excision of corneal/conjunctival intraepithelial neoplasia]. Nippon Ganka Gakkai Zasshi; 2010 Dec;114(12):1036-9
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  • [Title] [Pyogenic granuloma developing rapidly after excision of corneal/conjunctival intraepithelial neoplasia].
  • BACKGROUND: Pyogenic granuloma is a benign tumor presenting with a smooth hemorrhagic surface that develops on the ocular surface after trauma or ophthalmic surgery.
  • Abnormal wound healing due to physical and/or chemical stimulation may contribute to the pathogenesis of the tumor.
  • We herein report the usefulness of brushing cytology for diagnosis of pyogenic granuloma, which rapidly developed after surgical resection of corneal/conjunctial intraepithelial neoplasia (CIN).
  • CASE: A 70-year-old man presented with a flat tumor on the left lower conjunctiva in conjunction with the cornea.
  • The patient underwent excision of the tumor and cryotherapy.
  • The primary tumor was histologically diagnosed with CIN.
  • The secondary tumor was diagnosed as pyogenic granuloma.
  • CONCLUSIONS: It is possible to diagnose a secondary tumor based on information of the clinical course, slit-lamp examination and brushing cytology before the excision of CIN.
  • [MeSH-major] Carcinoma in Situ / surgery. Conjunctival Neoplasms / surgery. Corneal Diseases / surgery. Eye Neoplasms / surgery. Granuloma, Pyogenic / diagnosis. Granuloma, Pyogenic / etiology. Postoperative Complications
  • [MeSH-minor] Aged. Cytodiagnosis / methods. Diagnosis, Differential. Humans. Male


12. Singh R, Chattopadhyay A, Agarwal A, Bhattacharya SK, Bhattacharya AK: Oxidants and ocular tumors. Ann Ophthalmol (Skokie); 2006;38(3):231-4
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  • [Title] Oxidants and ocular tumors.
  • Serum superoxide dismutase and catalase assays were performed using spectrophotometry in 60 adults and children with benign or malignant tumors and in controls.
  • These enzymes may be of value in the early diagnosis of malignant intraocular tumor, especially retinoblastoma.
  • [MeSH-major] Eye Neoplasms / etiology. Oxidants / metabolism. Retinoblastoma / etiology

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  • (PMID = 17416959.001).
  • [ISSN] 1558-9951
  • [Journal-full-title] Annals of ophthalmology (Skokie, Ill.)
  • [ISO-abbreviation] Ann Ophthalmol (Skokie)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Oxidants; EC 1.11.1.6 / Catalase; EC 1.15.1.1 / Superoxide Dismutase
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13. Shields CL, Eagle RC, Ip MS, Marr BP, Shields JA: Two discrete uveal melanomas in a child with ocular melanocytosis. Retina; 2006 Jul-Aug;26(6):684-7
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  • [Title] Two discrete uveal melanomas in a child with ocular melanocytosis.
  • OBJECTIVE: To describe a case of two uveal melanomas in a child with mild ocular melanocytosis.
  • Ocular oncology evaluation revealed mild sectorial scleral and uveal melanocytosis and an episcleral sentinel vessel superotemporally.
  • In the circumpapillary and macular region, tumor 1 was diffuse at 9.0 mm in base and 4.1 mm in thickness and with overlying subretinal fluid.
  • In the ciliary body, tumor 2 was discovered by transillumination and was 6.0 mm in base and 2.2 mm in thickness.
  • Tumor 1 was a mixed, predominantly epithelioid cell melanoma with active mitotic figures, and tumor 2 was a mixed, predominantly spindle cell melanoma.
  • The choroid between the melanomas showed only benign, dendritic melanocytes consistent with melanocytosis.
  • CONCLUSIONS: Ocular melanocytosis can predispose to one or multiple uveal melanomas.
  • [MeSH-major] Melanocytes / pathology. Melanoma / pathology. Melanosis / pathology. Neoplasms, Multiple Primary / pathology. Uveal Neoplasms / pathology
  • [MeSH-minor] Child. Eye Enucleation. Female. Humans

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  • (PMID = 16829813.001).
  • [ISSN] 0275-004X
  • [Journal-full-title] Retina (Philadelphia, Pa.)
  • [ISO-abbreviation] Retina (Philadelphia, Pa.)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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14. Cohen VM, Shields CL, Furuta M, Shields JA: Vitreous seeding from retinal astrocytoma in three cases. Retina; 2008 Jun;28(6):884-8
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  • RESULTS: An asymptomatic 8-year-old boy (Case 1) presented with a white juxtapapillary retinal tumor and extensive overlying large vitreous seeds.
  • Fine-needle aspiration biopsy (FNAB) confirmed the diagnosis of benign retinal astrocytoma.
  • A 5-year-old boy (Case 2) presented with a large, multilobulated, tan juxtapapillary retinal tumor.
  • Histopathologic analysis of the enucleated globe supported the diagnosis of retinal astrocytoma.
  • The tumor height increased from 2.5 mm to 5.5 mm, and total retinal detachment developed.
  • After enucleation, the diagnosis of retinal astrocytoma was confirmed.
  • CONCLUSIONS: Retinal astrocytoma can produce vitreous seeds, sometimes associated with tumor growth.
  • Care should be taken to exclude the diagnosis of retinoblastoma.
  • [MeSH-major] Astrocytoma / secondary. Eye Neoplasms / secondary. Neoplasm Seeding. Retinal Neoplasms / pathology. Vitreous Body / pathology
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Eye Enucleation. Female. Humans. Male. Retrospective Studies

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  • (PMID = 18536607.001).
  • [ISSN] 0275-004X
  • [Journal-full-title] Retina (Philadelphia, Pa.)
  • [ISO-abbreviation] Retina (Philadelphia, Pa.)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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15. Livaoĝlu M, Cakir E, Karaçal N: Large orbital osteoma arising from orbital roof: Excision through an upper blepharoplasty incision. Orbit; 2009;28(2-3):200-2
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  • Osteoma is the most common benign tumor of facial bony structure.
  • The patient's ophtalmological examination revealed; only light perception due to the severe amblyopia and posterior capsular opacification in the right eye, and complete visual acuity in the left.
  • His left eye was proptotic and directed to downward lateral gaze position.
  • There were not any postoperative complications and all ocular symptoms in the left eye were resolved after 1 month.
  • [MeSH-major] Orbital Neoplasms / diagnosis. Orbital Neoplasms / surgery. Osteoma / diagnosis. Osteoma / surgery
  • [MeSH-minor] Biopsy, Needle. Blepharoplasty / methods. Blepharoptosis / diagnosis. Blepharoptosis / etiology. Follow-Up Studies. Humans. Imaging, Three-Dimensional. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Ophthalmologic Surgical Procedures / methods. Risk Assessment. Time Factors. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19839914.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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16. Alkatan HM, Al-Arfaj KM, Maktabi A: Conjunctival nevi: Clinical and histopathologic features in a Saudi population. Ann Saudi Med; 2010 Jul-Aug;30(4):306-12
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  • BACKGROUND AND OBJECTIVE: Conjunctival nevi are benign lesions with wide variation in clinical and histopathological features.
  • The differentiation between benign nevi and other pigmented lesions is essential.
  • The aim of our study was to identify the distribution of the histopathologic types of conjunctival nevi among the Saudi population and to provide the basic knowledge needed for proper clinical diagnosis.
  • PATIENTS AND METHODS: This retrospective study of surgically excised benign conjunctival nevi was conducted at a tertiary care eye hospital from 1995 to 2006.
  • CONCLUSIONS: The distribution of the histopathologic types of this tumor in our population matches the pattern in other areas of the world with the compound nevus being the commonest lesion.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Nevus, Pigmented / pathology

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  • (PMID = 20622349.001).
  • [ISSN] 0975-4466
  • [Journal-full-title] Annals of Saudi medicine
  • [ISO-abbreviation] Ann Saudi Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Other-IDs] NLM/ PMC2931783
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17. Gündüz K, Demirel S, Heper AO, Günalp I: A rare case of atypical chondroid syringoma of the lower eyelid and review of the literature. Surv Ophthalmol; 2006 May-Jun;51(3):280-5
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  • Biopsy nine years previously had not established a diagnosis.
  • Chondroid syringoma is a rare skin tumor that occurs, very rarely, in the eyelids, especially the lower eyelid.
  • The tumor can have benign, atypical, and malignant variants.
  • Our patient had the atypical variant, which is characterized by benign cytological features, as well as the presence of infiltrative margins and/or satellite nodules.
  • Even benign chondroid syringomas, if incompletely excised, can recur with malignant transformation; thus, complete excision and regular follow-up is recommended for all chondroid syringomas.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Eyelid Neoplasms / pathology
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Middle Aged

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  • (PMID = 16644368.001).
  • [ISSN] 0039-6257
  • [Journal-full-title] Survey of ophthalmology
  • [ISO-abbreviation] Surv Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Romero-Rojas AE, Díaz-Pérez JA, Lozano-Castillo A: [Malignant peripheric nerve sheath tumor of the orbit: first description of orbital location in a patient with NF1]. Neurocirugia (Astur); 2010 Feb;21(1):37-45
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  • [Title] [Malignant peripheric nerve sheath tumor of the orbit: first description of orbital location in a patient with NF1].
  • [Transliterated title] Tumor maligno de la vaina del nervio periférico (MPNST) glandular de la órbita: primera descripción de la literatura de localización orbitaria en un paciente con neurofibromatosis tipo 1.
  • INTRODUCTION: The malignant peripheric nerve sheath tumor (MPNST), is a malignant neoplastic lesion originated in Schwann cells of the lining sheath of peripheral nerves.
  • This neoplasia may appear with benign or malignant heterologous components, with divergent differentiation, as the glandular one.
  • CLINICAL CASE: Nine year old male, with a base diagnosis of NF1, who had exophthalmos, retro-ocular pain, headache, facial asymmetry and descent of the right eyeball, that started 1 year earlier.
  • This patient showed in the Computed Tomography an Magnetic Resonance, a well delimited, lobulated, solid mass at the eyeball, which extended to the fontal and temporal brain parenchyma.
  • The diagnosis of Glandular MPNST was made.
  • This extremely uncommon neoplasia must be taken into account, in the study of biphasic malignant lesions, as its diagnosis is of great importance because of the bad prognosis of the affected patients.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Neurofibromatosis 1 / pathology. Orbital Neoplasms / pathology

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  • (PMID = 20186373.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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19. Saw VP, Dart RJ, Galatowicz G, Daniels JT, Dart JK, Calder VL: Tumor necrosis factor-alpha in ocular mucous membrane pemphigoid and its effect on conjunctival fibroblasts. Invest Ophthalmol Vis Sci; 2009 Nov;50(11):5310-7
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  • [Title] Tumor necrosis factor-alpha in ocular mucous membrane pemphigoid and its effect on conjunctival fibroblasts.
  • PURPOSE: First, to determine whether tumor necrosis factor-(TNF)-alpha is expressed in the conjunctiva of ocular mucous membrane pemphigoid (MMP) and the consequences of systemic immunosuppressive treatment on this expression.
  • METHODS: The expression of TNFalpha in conjunctival tissues of patients with actively inflamed ocular MMP (n = 10), patients with clinically noninflamed ocular MMP after systemic immunosuppressive treatment (n = 10), and normal subjects (n = 10) was studied by immunohistochemistry.
  • RESULTS: In active ocular MMP, TNFalpha is expressed by a large number of stromal infiltrating cells (234 cells/mm(2)), and although the level of stromal TNFalpha expression is significantly reduced after immunosuppressive treatment (90 cells/mm(2)), these levels are still significantly elevated compared with normal conjunctiva (10 cells/mm(2), P < 0.05).
  • CONCLUSIONS: Increased conjunctival expression of TNFalpha in ocular MMP suggests that systemic TNFalpha antagonists are likely to be effective in controlling severe disease unresponsive to conventional systemic immunosuppression.
  • [MeSH-major] Conjunctiva / drug effects. Pemphigoid, Benign Mucous Membrane / metabolism. Tumor Necrosis Factor-alpha / metabolism. Tumor Necrosis Factor-alpha / pharmacology

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  • (PMID = 19494201.001).
  • [ISSN] 1552-5783
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Cell Adhesion Molecules; 0 / HLA-DR Antigens; 0 / Tissue Inhibitor of Metalloproteinases; 0 / Tumor Necrosis Factor-alpha; 9007-34-5 / Collagen; EC 3.4.24.- / Matrix Metalloproteinases
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20. Miaśkiewicz B, Lukomski M, Starska K, Józefowicz-Korczyńska M: [Ocular and orbital symptoms in benign sinonasal neopasmas]. Pol Merkur Lekarski; 2006 Feb;20(116):184-7
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  • [Title] [Ocular and orbital symptoms in benign sinonasal neopasmas].
  • Osteoma (0.01-0.4%) and inverted papilloma (0.5-4%) are the most common benign tumours of the nose and paranasal sinuses, whereas heamangioma occurs very rare.
  • Orbital and ocular symptoms are uncommon in these types of neoplasmas.
  • AIM OF THE STUDY: Analysis of symtoms, diagnostic procedures and treatment options in 10 patients with diagnosed orbital and ocular complications of benign tumours of the nose and paranasal sinuses.
  • Presenting orbital and ocular symptoms occured in 7 patients and in 3 left person orbital involvement was presented only radiographically and intraoperatively.
  • RESULTS: Nine of the patients were operated: 4--lateral rhinotomies, 2--Denker's operations, 2--operations of sinus frontalis and/or ethmoidalis by external approach and in 1 case resection of maxilllary sinus's tumor were performed.
  • The rest of patients stay without recurrences of tumor.
  • CONCLUSION: Orbital and ocular symptoms in benign tumors of nose and paranasal sinuses do not always correlate with radiologic and intraoperative findings.
  • [MeSH-major] Headache / epidemiology. Hemangioma / epidemiology. Nose Neoplasms / epidemiology. Orbit / physiopathology. Pain / epidemiology. Pain / physiopathology. Papilloma, Inverted / epidemiology. Paranasal Sinus Neoplasms / epidemiology

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  • (PMID = 16708636.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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21. Yan XM, Chen Y, Li HL, Rong B, Yang SL: [Retrospective analysis of ocular cicatricial pemphigoid]. Zhonghua Yan Ke Za Zhi; 2010 Sep;46(9):781-4
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  • [Title] [Retrospective analysis of ocular cicatricial pemphigoid].
  • OBJECTIVE: To analyze the clinical characterization of ocular cicatricial pemphigoid (OCP).
  • It was two to five years from the first time to see a doctor to definite diagnosis.
  • All of cases have been prescribed antibiotic eye drops for a long times, one case has been undergone three times trichiasis operation and made the disease progression.
  • Only in 1 case, there was slight increase of iron protein as tumor mark.
  • [MeSH-major] Diagnostic Errors. Pemphigoid, Benign Mucous Membrane


22. George JL, Marchal JC: [Orbital tumors in children: clinical examination, imaging, specific progression]. Neurochirurgie; 2010 Apr-Jun;56(2-3):244-8
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  • [Transliterated title] Les tumeurs d'orbite de l'enfant : examen clinique, paraclinique, diagnostic et particularités évolutives.
  • "Orbital tumors (OT) are neoplasms of the bony orbit and contents except for the eyeball."
  • Examination must be careful: measurement, direction of proptosis, impairment of ocular motility, compressive optic neuropathy, strabismus, etc.
  • Benign tumors such as dermoid cysts or hemangiomas grow slowly, whereas rapid growth suggests a malignant tumor.
  • When a metastatic tumor is suspected, abdominal palpation and ultrasonography must be performed.
  • Most of the time, standard x-rays, CT, and MR imaging allow for an adequate assessment and usually provide a diagnosis.
  • [MeSH-major] Orbital Neoplasms / diagnosis
  • [MeSH-minor] Adult. Age Factors. Child. Disease Progression. Emotions. Exophthalmos / etiology. Humans. Leukemia / diagnosis. Leukemia / epidemiology. Leukemia / pathology. Neoplasm Metastasis / pathology. Neuroblastoma / diagnosis. Neuroblastoma / epidemiology. Neuroblastoma / pathology. Palpation. Rhabdomyosarcoma / diagnosis. Rhabdomyosarcoma / epidemiology. Rhabdomyosarcoma / pathology

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20303555.001).
  • [ISSN] 1773-0619
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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23. Benatiya Andaloussi I, Touiza E, Bhallil S, Oudidi A, Bouayed MA, Daoudi K, El Alami MN, Tahri H: Orbital osteoma: three case reports. Bull Soc Belge Ophtalmol; 2006;(300):73-9
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  • INTRODUCTION: Osteoma is the most frequent benign tumor of paranasal sinuses.
  • The management consisted in a surgical excision of the whole tumor by external approach, associated with a dacryocystorhinostomy.
  • 2nd observation: Miss K.A. is a 16 years-old caucasian female who came to consultation for a swelling of the medial angle of the left eye.
  • The tumor was removed through an external ethmoidectomy.
  • The computed tomography is of a great contribution, not only for diagnosis but also for the choice of the surgical approach.
  • This surgery may induce ocular or neurochirurgical complications.
  • [MeSH-major] Orbital Neoplasms / diagnosis. Osteoma / diagnosis

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  • (PMID = 16903514.001).
  • [ISSN] 0081-0746
  • [Journal-full-title] Bulletin de la Société belge d'ophtalmologie
  • [ISO-abbreviation] Bull Soc Belge Ophtalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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24. Ohnishi Y, Saika S, Yamanaka O, Okada Y, Shirai K, Miyamoto T, Nishikawa I, Tanaka T, Miyazaki K: [Investigation of mechanism of cell proliferation regulation and its clinical application]. Nippon Ganka Gakkai Zasshi; 2005 Dec;109(12):865-83; discussion 884
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  • Cell proliferation and related cellular behavior in ocular neoplastic disease and in the healing process in ocular surgery or post-injury management, as well as new treatment strategy were investigated.
  • Cell proliferation-related signals were found to be activated to a greater extent in malignant ocular tumors than in benign tumor cells regardless of the similarity of simple histological findings.
  • Suppression of cell proliferation-related signals can be a new treatment for ocular neoplastic diseases.
  • [MeSH-minor] Animals. Eye Neoplasms / pathology. Eye Neoplasms / therapy. Gene Expression Regulation, Developmental. Genetic Therapy. Hedgehog Proteins. Humans. Ocular Physiological Phenomena. Trans-Activators / physiology. Wound Healing / genetics. Wound Healing / physiology

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  • (PMID = 16408488.001).
  • [ISSN] 0029-0203
  • [Journal-full-title] Nippon Ganka Gakkai zasshi
  • [ISO-abbreviation] Nippon Ganka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Hedgehog Proteins; 0 / Smad Proteins; 0 / Trans-Activators; 0 / Transcription Factor AP-1; 0 / Transforming Growth Factor beta
  • [Number-of-references] 77
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25. Feyma T, Carter GT, Weiss MD: Myotonic dystrophy type 1 coexisting with myasthenia gravis and thymoma. Muscle Nerve; 2008 Jul;38(1):916-20
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  • Myotonic dystrophy type 1 (DM1) is an autosomal-dominant multisystemic disorder that may rarely be associated with benign and malignant neoplasms.
  • We present a 51-year-old man with a family history of DM1 and fluctuating diplopia and ptosis, who was found to have acetylcholine receptor-binding antibodies, thymoma, and a clinical presentation compatible with ocular myasthenia gravis as well as positive genetic testing for DM1.
  • Needle electromyographic (EMG) study demonstrated diffuse runs of myotonic discharges in multiple muscles, consistent with the diagnosis of DM1.
  • Due to somatic instability, which has been shown previously in DM1, the myotonin protein kinase (DMPK) gene appears to act as a tumor suppressor.
  • [MeSH-major] Myasthenia Gravis / complications. Myasthenia Gravis / pathology. Myotonic Dystrophy / complications. Myotonic Dystrophy / pathology. Thymoma / complications. Thymoma / pathology. Thymus Neoplasms / complications. Thymus Neoplasms / pathology


26. Perlmann E, da Silva EG, Guedes PM, Barros PS: Co-existing squamous cell carcinoma and hemangioma on the ocular surface of a cat. Vet Ophthalmol; 2010 Jan;13(1):63-6
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  • [Title] Co-existing squamous cell carcinoma and hemangioma on the ocular surface of a cat.
  • A 14-year-old spayed female domestic short-haired cat was presented for evaluation of a mass in the right eye.
  • Ophthalmic examination revealed a blind right eye and presence of two distinct masses: a pink and a red-to-brown mass, the latter occupying most of the cornea and part of the conjunctiva.
  • Exenteration was performed under general anesthesia, and the ocular tissues were processed routinely for histopathology.
  • Upon microscopic examination, a malignant epithelial neoplasm and a benign vascular neoplasm were present in the cornea.
  • Upon immunohistochemistry, the epithelial tumor was positive for cytokeratin and negative for vimentin and the endothelial tumor was negative for cytokeratin and positive for vimentin.
  • A diagnosis of squamous cell carcinoma (SCC) and hemangioma was made.
  • To the authors' knowledge, this is the first report of concomitant SCC and hemangioma affecting the ocular surface in a cat.
  • [MeSH-major] Carcinoma, Squamous Cell / veterinary. Cat Diseases / pathology. Eye Neoplasms / veterinary. Hemangioma / veterinary. Neoplasms, Multiple Primary / veterinary


27. Lavaju P, Arya SK, Sinha A, Pandey S, Adhikari S, Shrestha BG, Chetan S, Agarwal TL: Pattern of ocular tumors in the eastern region of Nepal. Nepal J Ophthalmol; 2009 Jan-Jun;1(1):9-12
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  • [Title] Pattern of ocular tumors in the eastern region of Nepal.
  • BACKGROUND: ocular tumors are commonly encountered in ophthalmic practice.
  • OBJECTIVE: to study the clinical pattern of ocular tumors in the eastern region of Nepal.
  • MATERIALS AND METHODS: the hospital records of patients with ocular tumors treated at B P Koirala Institute of Health Sciences in the eastern region of Nepal over a period of 5 years (April 2003 - March 2008) were studied retrospectively.
  • RESULTS: of 115 consecutive patients with ocular tumors, 40 (34.75%) were below the age of 21 years, 41 (35.65%) were in the age group of 21-50 years and 34 (29.56%) of age above 50 years.
  • There were 48 (41.73%) and 67 (58.26%) patients with benign and malignant tumors respectively.
  • The common benign tumors were conjunctival papilloma, dermoid cysts, nevus, cystic lesions and hemangioma.
  • Retinoblastoma was the most common ocular malignant tumor in the pediatric age group (88.8%).
  • CONCLUSION: conjunctival papilloma, dermoid cysts, nevus, cystic lesions and hemangioma are common benign ocular tumors, whereas basal cell carcinoma and retinoblastoma are the commonest ocular malignancies in adults and children respectively.
  • [MeSH-major] Eye Neoplasms / epidemiology

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  • (PMID = 21141015.001).
  • [ISSN] 2072-6805
  • [Journal-full-title] Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH
  • [ISO-abbreviation] Nepal J Ophthalmol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Nepal
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28. Rodrigues EB, Shields CL, Eagle RC Jr, Marr BP, Shields JA: Solitary intraosseous orbital myofibroma in four cases. Ophthal Plast Reconstr Surg; 2006 Jul-Aug;22(4):292-5
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  • PURPOSE: To report four pediatric cases of a bone-destructive orbital tumor that proved to be a benign solitary intraosseous myofibroma.
  • The diagnosis was also supported by immunohistochemical studies showing positive immunoreactivity for vimentin and smooth muscle actin.
  • CONCLUSIONS: Myofibroma is a benign tumor that can occur in the orbital bony wall of children.
  • [MeSH-major] Myofibroma / pathology. Orbital Neoplasms / pathology

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  • (PMID = 16855503.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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29. Hałoń A, Błazejewska M, Sabri H, Rabczyński J: [Tumors and tumor-like lesions of eyelids collected at Department of Pathological Anatomy, Wroclaw Medical University, between 1946 and 1999]. Klin Oczna; 2005;107(7-9):475-8
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  • [Title] [Tumors and tumor-like lesions of eyelids collected at Department of Pathological Anatomy, Wroclaw Medical University, between 1946 and 1999].
  • PURPOSE: To determine the histopathological, epidemiological and clinical characteristics of benign, malignant and tumor-like lesions of the eyelid collected in Department of Pathological Anatomy, Wrocław Medical University.
  • MATERIAL AND METHODS: Department of Pathological Anatomy, Wrocław Medical University, has been collecting data of all tumors and tumor-like lesions of the eye and ocular adnexa diagnosed at the department during the 54-year interval from 1946 through 1999.
  • RESULTS: There were 4818 cases of the eye and ocular adnexa lesions diagnosed at the department since 1946 and 1999, what made up 0.262% of all diagnosed cases.
  • The eyelids were the most common localization of malignant tumors (39.9% cases of all eye regions).
  • The incidence cohort of all eyelid lesions included 2031 cases what made up 42.15% of all diagnosed lesions within the eye and it's adnexa.
  • Benign tumors were the most common lesions (n=1262; 62.2%).
  • Almost 2/3 of all tumor-like lesions in both genders were cysts including atheromas.
  • CONCLUSIONS: Benign eyelid tumors compose the majority of all eyelid lesions.
  • The eyelids are the most common localization of malignant tumors within the eye and it's adnexa.
  • Basal cell carcinoma is the most common malignant eyelid tumor.
  • [MeSH-major] Carcinoma / epidemiology. Eyelid Neoplasms / epidemiology. Papilloma / epidemiology

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  • (PMID = 16417001.001).
  • [ISSN] 0023-2157
  • [Journal-full-title] Klinika oczna
  • [ISO-abbreviation] Klin Oczna
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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30. Sarnat HB, Flores-Sarnat L: Embryology of the neural crest: its inductive role in the neurocutaneous syndromes. J Child Neurol; 2005 Aug;20(8):637-43
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  • After dorsal closure of the neural tube, neural crest cells separate and migrate throughout the embryo to form many structures of ectodermal origin (eg, dorsal root and autonomic ganglia, peripheral nerve sheaths) and mesodermal origin (eg, blood vessels, melanocytes, adipose tissue, membranous bone, connective tissue, most of the ocular globe).
  • Abnormal angiogenesis, areas of abnormal pigmentation that sometimes follow the lines of Blashko, nerve sheath proliferations, disorders of chromaffin tissue, lipomes and benign and malignant tumors are frequent features.
  • Many defective genes in neurocutaneous syndromes have an additional function as tumor suppressors.
  • The craniofacial abnormalities associated with many cerebral malformations and cutaneous lesions in some neurocutaneous syndromes emphasize an important inductive role of the neural tube in the development of non-neural tissues, mediated through neural crest.

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  • (PMID = 16225807.001).
  • [ISSN] 0883-0738
  • [Journal-full-title] Journal of child neurology
  • [ISO-abbreviation] J. Child Neurol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 74
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31. Randriamora JT, Andrianilana H, Rarivomanana M, Raherizaka N, Rakotovao F, Rasoavelonoro VA: [Voluminous mucocele of frontal sinus with superior eyelid and orbit expansion]. J Fr Ophtalmol; 2005 Jan;28(1):55-8
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  • INTRODUCTION: A mucocele is an unusual benign cystic tumor, frequently seen in the adult and affecting mucous sinuses that expand the orbit by bone destruction.
  • DESCRIPTION: A 72-year-old man, without a history of sinus disease, presented a voluminous mucocele of the right frontal sinus that had begun 3 years before, with superior eyelid and orbit expansion hiding and pushing the eye to the downside and the outside.
  • After surgery, the patient recovered visual function without diplopia, and normal eyelid and ocular motility.
  • However, the right eye is abnormally sized a bit downside.

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  • (PMID = 15767900.001).
  • [ISSN] 0181-5512
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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32. Windisch-Furrer R, Kurz-Levin MM, Sutter FK, Reineke T, Helbig H: [Vasoproliferative retinal tumors]. Klin Monbl Augenheilkd; 2007 Apr;224(4):364-6
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  • [Transliterated title] Vasoproliferative retinale Tumore.
  • BACKGROUND: Vasoproliferative Tumors of the retina (VPTR) are benign tumors of unknown origin, occurring mostly in otherwise systemically healthy patients.
  • These highly vascularised tumors are characterised by a pink to yellow colour on funduscopy and are usually situated in the inferior part of the retina.
  • In one case the tumour was surgically excised and histology was performed.
  • CONCLUSIONS: VPTR of the ocular fundus are a distinct entity in the differential diagnosis of intraocular tumors.
  • These benign lesions represent reactive gliovascular proliferations, with varying degrees of both gliosis and of vascular proliferation.
  • VPTR can be idiopathic, or they develop after inflammatory, vascular, traumatic, dystrophic or degenerative ocular diseases, in particular, uveitis.
  • The major differential diagnosis includes other vascular lesions or tumors of the ocular fundus like capillary retinal hemangiomas, Coat' Disease or malignancies.
  • The therapy is based on tumor size, localisation and complications.
  • [MeSH-major] Neoplasms, Vascular Tissue / diagnosis. Neoplasms, Vascular Tissue / therapy. Retinal Neoplasms / diagnosis. Retinal Neoplasms / therapy. Retinal Neovascularization / diagnosis. Retinal Neovascularization / therapy
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 17458816.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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33. Cordero Coma M, Yilmaz T, Foster CS: Tumour necrosis factor-alpha in conjunctivae affected by ocular cicatricial pemphigoid. Acta Ophthalmol Scand; 2007 Nov;85(7):753-5
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  • [Title] Tumour necrosis factor-alpha in conjunctivae affected by ocular cicatricial pemphigoid.
  • PURPOSE: The presence of tumour necrosis factor-alpha (TNF-alpha) in conjunctivae affected by ocular cicatricial pemphigoid (OCP) was investigated.
  • [MeSH-major] Conjunctiva / metabolism. Conjunctivitis, Allergic / metabolism. Pemphigoid, Benign Mucous Membrane / metabolism. Tumor Necrosis Factor-alpha / metabolism


34. Okuda T, Hanamure Y, Kasano F, Kashima N: [Isolated sphenoid sinus lesions: a clinical analysis of 44 cases]. Nihon Jibiinkoka Gakkai Kaiho; 2005 Sep;108(9):835-41
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  • Of these, 32 had inflammatory disease, 8 mucocele, 1 a benign tumor, and 3 malignant tumors.
  • The most common symptoms were headache at 59% followed by ocular symptoms at 27%.
  • Ocular symptoms included ocular pain in 60% of those with inflammatory disease, visual disturbance in 63% of those with mucocele, and diplopia in all of those with neoplasms.
  • CONCLUSION: The type of ocular symptom largely depends on ISL pathology.
  • Patients with headaches and diplopia have a high ratio of malignant neoplasms.
  • It is most important to differentiate pathological disease that requires early diagnosis and therapy such as acute inflammatory disease, mucocele with visual disturbance, and malignant tumors.
  • [MeSH-minor] Humans. Paranasal Sinus Diseases / diagnosis. Paranasal Sinus Diseases / therapy. Retrospective Studies

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  • (PMID = 16218441.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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35. Dégi R, Szabó A, Janáky M: [Experience in 13-year follow-up of a melanocytoma of the optic nerve head]. Magy Onkol; 2005;49(1):31-4
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  • Thirteen years ago, a 35-year-old woman was found on routine ocular examination to have a pigmented tumor in her right eye, adjacent to the optic nerve head.
  • Ultrasound examination revealed that the tumor diameter was 4.4 mm on the base and the maximal thickness was 2.7 mm.
  • There were several additional examinations (e.g. determination of the visual field, measurement of the intraocular pressure, detection of visually evoked potentials, CT scan and MRI examination) to exclude a benign tumor of similar appearance, The patient underwent ocular examination every year.
  • During the observation period a minor tumor enlargement occurred but there were no changes in the visual acuities.
  • The findings documented and illustrated here suggest that our methods were useful to differentiate the melanocytoma from a malignant melanoma, and no surgical interventions were needed to characterize or to remove the tumor.
  • [MeSH-major] Melanocytes. Melanoma / diagnosis. Optic Nerve Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Fluorescein Angiography. Follow-Up Studies. Humans. Middle Aged

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  • (PMID = 15902331.001).
  • [ISSN] 0025-0244
  • [Journal-full-title] Magyar onkologia
  • [ISO-abbreviation] Magy Onkol
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
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36. Orawiec B, Grałek M, Stefańczyk L, Niwald A: Applicability of ultrasound in ocular tumors in children and adolescents. Klin Oczna; 2005;107(7-9):437-41
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  • [Title] Applicability of ultrasound in ocular tumors in children and adolescents.
  • PURPOSE: Evaluation of the applicability of ultrasound in children diagnosed for neoplasm of the eye.
  • Evaluation of Doppler ultrasound in visualizing blood vessels within the lesion in eye ball, eye socket and eye lids.
  • Establishing the value of the obtained data concerning the image of vessels and blood flow for the diagnosis, monitoring the course of disease and results of treatment.
  • MATERIAL AND METHODS: The study comprised 80 patients diagnosed and treated for neoplasm of the eye.
  • The presence of vessels in tumor mass and blood flow in tumors were useful for differentiation between malignant and benign tumors.
  • The obtained pictures of vessels and flow character are typical for some tumors, which together with histopathology of tumors enables establishing of correct diagnosis.
  • [MeSH-major] Eye Neoplasms / ultrasonography

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  • (PMID = 16416991.001).
  • [ISSN] 0023-2157
  • [Journal-full-title] Klinika oczna
  • [ISO-abbreviation] Klin Oczna
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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37. Prey S, Robert PY, Drouet M, Sparsa A, Roux C, Bonnetblanc JM, Bédane C: Treatment of ocular cicatricial pemphigoid with the tumour necrosis factor alpha antagonist etanercept. Acta Derm Venereol; 2007;87(1):74-5
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  • [Title] Treatment of ocular cicatricial pemphigoid with the tumour necrosis factor alpha antagonist etanercept.
  • [MeSH-major] Eye Diseases / drug therapy. Immunoglobulin G / therapeutic use. Immunosuppressive Agents / therapeutic use. Pemphigoid, Benign Mucous Membrane / drug therapy. Receptors, Tumor Necrosis Factor / therapeutic use
  • [MeSH-minor] Aged, 80 and over. Etanercept. Female. Humans. Treatment Outcome. Tumor Necrosis Factor-alpha / antagonists & inhibitors

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  • (PMID = 17225020.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Immunoglobulin G; 0 / Immunosuppressive Agents; 0 / Receptors, Tumor Necrosis Factor; 0 / Tumor Necrosis Factor-alpha; OP401G7OJC / Etanercept
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38. Kernt M, Schaller UC, Stumpf C, Ulbig MW, Kampik A, Neubauer AS: Choroidal pigmented lesions imaged by ultra-wide-field scanning laser ophthalmoscopy with two laser wavelengths (Optomap). Clin Ophthalmol; 2010;4:829-36
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  • Choroidal melanoma is the most prevalent primary neoplasia among malignant ocular tumors, and metastasis often occurs before the primary tumor is diagnosed.
  • We investigated the imaging properties of clinically diagnosed melanocytic choroidal tumors using a nonmydriatic ultra-wide-field scanning laser ophthalmoscope (SLO) with two laser wavelengths to distinguish benign from malignant lesions.
  • METHODS: In a consecutive series of 49 patients with clinically diagnosed melanocytic choroidal tumors in one eye, 29 had established melanoma (defined by proven growth on repeated US follow-up) and 20 had nevi (defined by no malignancy according to clinical, US, and growth characteristics for at least 2 years).
  • Measurements of the tumor base using the Optomap software were compared with US B-scan measurements.
  • RESULTS: Measurements of tumor base correlated well between SLO and US with r = 0.61 (T-direction) and r = 0.51 (L-direction).
  • CONCLUSIONS: In this first, limited series, nonmydriatic SLO imaging with two laser wavelengths permitted to differentiate malignant ocular tumors from nonmalignant lesions with high diagnostic accuracy.

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  • (PMID = 20689737.001).
  • [ISSN] 1177-5483
  • [Journal-full-title] Clinical ophthalmology (Auckland, N.Z.)
  • [ISO-abbreviation] Clin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC2915871
  • [Keywords] NOTNLM ; choroidal melanoma / imaging / nevus / ultra-wide-field scanning laser ophthalmoscopy
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39. Allen BJ, Raja C, Rizvi S, Li Y, Tsui W, Graham P, Thompson JF, Reisfeld RA, Kearsley J: Intralesional targeted alpha therapy for metastatic melanoma. Cancer Biol Ther; 2005 Dec;4(12):1318-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This paper reports the development and application of intralesional targeted alpha therapy (TAT) for melanoma, being the first part of a program to establish a new systemic therapy.
  • RATIONALE: Labelling the benign targeting vector 9.2.27 with 213Bi forms the alpha-immunoconjugate (AIC), which is highly cytotoxic to targeted melanoma cells.
  • AIC doses from 50 to 450 mCi injected into lesions of different sizes resulted in massive cell death, as observed by the presence of tumour debris.
  • The AIC was very effective in delivering a high dose to the tumour while sparing other tissues.
  • MIA, apoptosis and ki67 proliferation marker tests all indicated that TAT is a promising therapy for the control of inoperable secondary melanoma or primary ocular melanoma.
  • [MeSH-major] Alpha Particles / therapeutic use. Antibodies, Bispecific / therapeutic use. Bismuth / therapeutic use. Melanoma / radiotherapy. Skin Neoplasms / radiotherapy
  • [MeSH-minor] Aged. Aged, 80 and over. Antibodies, Monoclonal / chemistry. Biomarkers, Tumor / blood. Female. Half-Life. Humans. Immunoconjugates / adverse effects. Immunoconjugates / pharmacokinetics. Immunoconjugates / therapeutic use. Injections, Intralesional. Male. Middle Aged. Neoplasm Metastasis. Tissue Distribution

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  • [CommentIn] Cancer Biol Ther. 2006 Jan;5(1):118-9 [16491043.001]
  • (PMID = 16322682.001).
  • [ISSN] 1538-4047
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase I; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Bispecific; 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / Immunoconjugates; U015TT5I8H / Bismuth
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40. Tandon A, Branson HM, Buncic JR: Transient visual loss and isolated disk edema in juvenile nasopharyngeal angiofibroma. J AAPOS; 2010 Feb;14(1):90-2
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  • Juvenile nasopharyngeal angiofibroma is a well-described but rare benign tumor that mainly affects adolescent boys.
  • Although it is capable of extravagant local extension and tissue destruction, the tumor is amenable to effective therapy.
  • Ocular or visual complications have been little noted in the literature.

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  • [Copyright] Copyright (c) 2010 American Association for Pediatric Ophthalmology and Strabismus. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20045362.001).
  • [ISSN] 1528-3933
  • [Journal-full-title] Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
  • [ISO-abbreviation] J AAPOS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Apostol S, Filip M, Nechita A, Filip A: A lymphoid conjunctival tumor--clinical aspects; therapeutical options. Oftalmologia; 2005;49(1):26-9
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  • [Title] A lymphoid conjunctival tumor--clinical aspects; therapeutical options.
  • The therapeutical and also investigational approach was to excise all suspected tissue and to biopsy to determine if benign or malignant (clinically indistinguishable).
  • The conjunctival biopsy revealed a non-Hodgkin malignant conjunctival MALT lymphoma.
  • In this case, of ocular adnexal MALT lymphoma with localised disease, we took into account local treatment: external beam radiation therapy, topical use of chemotherapy agents and biologic therapy (subconjunctival injections with interferon-alpha).
  • [MeSH-major] Conjunctival Neoplasms. Lymphoma, B-Cell, Marginal Zone

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  • (PMID = 15934333.001).
  • [ISSN] 1220-0875
  • [Journal-full-title] Oftalmologia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Oftalmologia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Hormonal
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42. Shields CL, Shields JA: Conjunctival tumors in children. Curr Opin Ophthalmol; 2007 Sep;18(5):351-60
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  • Overall, 97% prove to be benign and only 3% are malignant.
  • SUMMARY: Conjunctival nevus is the most common conjunctival tumor in children and fewer than 1% evolve into melanoma over time.
  • [MeSH-major] Conjunctival Neoplasms / pathology

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  • (PMID = 17700226.001).
  • [ISSN] 1040-8738
  • [Journal-full-title] Current opinion in ophthalmology
  • [ISO-abbreviation] Curr Opin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 51
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43. Maheshwari R, Maheshwari S, Shekde S: Role of fine needle aspiration cytology in diagnosis of eyelid sebaceous carcinoma. Indian J Ophthalmol; 2007 May-Jun;55(3):217-9
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  • [Title] Role of fine needle aspiration cytology in diagnosis of eyelid sebaceous carcinoma.
  • Sebaceous carcinoma of the ocular adnexa is a malignant neoplasm which can exhibit aggressive local behavior and can metastasize to regional lymph nodes and distant organs.
  • The neoplasm is known to masquerade as other benign and less malignant lesions, resulting in delay in diagnosis and relative high morbidity and mortality.
  • Subsequently histopathology confirmed the diagnosis of sebaceous gland carcinoma.
  • Eyelid reconstruction was done after histopathologically confirmed tumor-free margins.
  • The article highlights the role of FNAC in early diagnosis and subsequent appropriate surgical management of eyelid sebaceous gland carcinoma to prevent recurrence and metastasis.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Biopsy, Fine-Needle. Eyelid Neoplasms / pathology. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged, 80 and over. Early Diagnosis. Female. Humans. Male. Middle Aged

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  • (PMID = 17456941.001).
  • [ISSN] 0301-4738
  • [Journal-full-title] Indian journal of ophthalmology
  • [ISO-abbreviation] Indian J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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44. Boonman ZF, van Mierlo GJ, Fransen MF, de Keizer RJ, Jager MJ, Melief CJ, Toes RE: Maintenance of immune tolerance depends on normal tissue homeostasis. J Immunol; 2005 Oct 1;175(7):4247-54
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  • In this study, we analyzed whether tolerance toward an intraocular tumor expressing a highly immunogenic CTL epitope is maintained, broken, or reverted into immunity in the event the anatomical integrity of the eye is lost.
  • Inoculation of tumor cells into the anterior chamber of the eye of naive B6 mice leads to progressive intraocular tumor growth, an abortive form of CTL activation in the tumor-draining submandibular lymph node, and systemic tolerance as evidenced by the inability of these mice to reject an otherwise benign tumor cell inoculum.
  • Loss of anatomical integrity of the eye as a consequence of phthisis resulted in loss of systemic tolerance and the emergence of effective antitumor immunity against an otherwise lethal tumor challenge.
  • Phthisis was accompanied by dendritic cell maturation and preceded the induction of systemic tumor-specific CTL immunity.
  • Our data show that normal tissue homeostasis and anatomical integrity is required for the maintenance of ocular tolerance and prevention of CTL-mediated immunity.
  • [MeSH-major] Eye Neoplasms / immunology. Homeostasis / immunology. Immune Tolerance / physiology
  • [MeSH-minor] Animals. Anterior Chamber / immunology. Antigen Presentation / immunology. Antigen-Presenting Cells / metabolism. Antigens, CD11c / metabolism. Antigens, Neoplasm / immunology. Cell Line, Transformed. Cell Line, Tumor. Cross-Priming / immunology. Mice. Mice, Inbred C57BL. Mice, Knockout. Mice, Transgenic. T-Lymphocytes, Cytotoxic / immunology

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  • (PMID = 16177064.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD11c; 0 / Antigens, Neoplasm
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45. Shields JA, Eagle RC Jr, Shields CL, Brown GC, Lally SE: Malignant transformation of congenital hypertrophy of the retinal pigment epithelium. Ophthalmology; 2009 Nov;116(11):2213-6
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  • METHODS: A 56-year-old black woman was referred for an asymptomatic fundus lesion in her left eye.
  • It had features typical of CHRPE, but there was a small elevated nodule within the flat component, and the diagnosis was adenoma of the retinal pigment epithelium (RPE) arising from CHRPE.
  • Thirteen years after the initial diagnosis, the patient returned with severe visual loss and no view of the fundus resulting from cataract and posterior synechia.
  • Ultrasonography revealed a total retinal detachment and a pedunculated tumor measuring 7.5 mm in thickness.
  • The eye was enucleated and studied histopathologically.
  • MAIN OUTCOME MEASURES: Clinical evaluation and correlation of clinical findings with histopathologic results of the enucleated eye.
  • RESULTS: Histopathologically, the mass was composed of a proliferation of atypical RPE cells with a marked infiltration of benign plasma cells.
  • Typical features of CHRPE were present at the base of the tumor.
  • The final diagnosis was adenocarcinoma arising from CHRPE.
  • CONCLUSIONS: Congenital hypertrophy of the retinal pigment epithelium, once considered to be a benign and stationary lesion, may spawn a malignant neoplasm.
  • [MeSH-major] Adenocarcinoma / pathology. Cell Transformation, Neoplastic / pathology. Retinal Neoplasms / pathology. Retinal Pigment Epithelium / pathology
  • [MeSH-minor] Eye Enucleation. Female. Humans. Hypertrophy / congenital. Middle Aged. Retinal Detachment / pathology. Retinal Detachment / ultrasonography

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  • (PMID = 19744732.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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46. Canizares MJ, Smith DI, Conners MS, Maverick KJ, Heffernan MP: Successful treatment of mucous membrane pemphigoid with etanercept in 3 patients. Arch Dermatol; 2006 Nov;142(11):1457-61
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  • BACKGROUND: Mucous membrane pemphigoid (MMP), also known as cicatricial pemphigoid, is a serious, autoimmune, blistering disorder that can result in blindness and other complications as a result of scarring of the mucous membranes.
  • All 3 patients had oral mucosal involvement, and 1 had severe, recalcitrant, ocular disease.
  • The patient with ocular involvement experienced stabilization of progression.
  • Etanercept may be an effective treatment option for MMP of the oral and ocular mucous membranes.
  • [MeSH-major] Immunoglobulin G / therapeutic use. Immunologic Factors / therapeutic use. Pemphigoid, Benign Mucous Membrane / drug therapy. Receptors, Tumor Necrosis Factor / therapeutic use. Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • [MeSH-minor] Conjunctival Diseases / complications. Conjunctival Diseases / diagnosis. Conjunctival Diseases / drug therapy. Conjunctival Diseases / pathology. Diagnosis, Differential. Etanercept. Female. Humans. Injections, Subcutaneous. Middle Aged. Severity of Illness Index

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  • (PMID = 17116836.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunoglobulin G; 0 / Immunologic Factors; 0 / Receptors, Tumor Necrosis Factor; 0 / Tumor Necrosis Factor-alpha; OP401G7OJC / Etanercept
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47. Bajaj MS, Pushker N, Kashyap S, Sen S, Vengayil S, Chaturvedi A: Fibrous histiocytoma of the lacrimal gland. Ophthal Plast Reconstr Surg; 2007 Mar-Apr;23(2):145-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Fibrous histiocytoma, a primary mesenchymal tumor of the orbit, is known to arise from various ocular and adnexal tissues.
  • We are unable to find a published report of this tumor originating from the lacrimal gland.
  • We report a case of a benign fibrous histiocytoma of the lacrimal gland in an 11 year old girl who presented with painless, progressive eyelid swelling and mild proptosis.
  • The tumor was completely excised by anterolateral orbitotomy.
  • Light microscopy showed a spindle cell tumor arising from the lacrimal gland.
  • The tumor cells were arranged in a characteristic storiform (cartwheel) pattern with no pleomorphism or mitotic figures.
  • Immunohistochemically, the tumor cells were focally positive for CD-68 and negative for S-100, smooth muscle actin, vimentin, and CD-34, which ruled out neurofibroma, leiomyoma, solitary fibrous tumor, and hemangiopericytoma.
  • Based on these features, a diagnosis of benign fibrous histiocytoma was made.
  • [MeSH-major] Eye Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology. Lacrimal Apparatus Diseases / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Child. Female. Humans. Neoplasm Proteins / analysis. Tomography, X-Ray Computed

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  • (PMID = 17413632.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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48. Kiratli H, Bulur B, Bilgiç S: Transconjunctival approach for retrobulbar intraconal orbital cavernous hemangiomas. Orbital surgeon's perspective. Surg Neurol; 2005 Jul;64(1):71-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Cavernous hemangioma is the most common benign intraorbital tumor found in adults.
  • The presumptive preoperative diagnosis was based on magnetic resonance imaging findings.
  • The tumor was exposed via a transconjunctival route after temporarily disinserting an extraocular muscle depending on the location of the lesion.
  • RESULTS: In all patients, the tumor was in touch with the globe and in most cases extended to the orbital apex.
  • This method is best for tumors whose anterior borders are in contact or very close to the eye even if the posterior border abuts the orbital apex.
  • [MeSH-major] Hemangioma, Cavernous / surgery. Neurosurgical Procedures / methods. Orbital Neoplasms / surgery

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  • [CommentIn] Surg Neurol. 2006 Mar;65(3):316; author reply 316 [16488268.001]
  • (PMID = 15993191.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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49. Levy-Gabriel C: [Suspicious conjunctival lesions]. J Fr Ophtalmol; 2010 Feb;33(2):125-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Taches suspectes de la conjonctive.
  • The main conjunctival tumors are represented by (i) conjunctival melanoma, ocular surface squamous neoplasia, and conjunctival lymphoma, which are malignant tumors, and (ii) conjunctival nevus, papilloma, and choristoma, which are benign.
  • Indeed, the therapeutic approach to these two malignant diseases presents a number of particularities such as the need for surgery under general anesthesia, if possible, to minimize the risk of local dissemination and further local recurrence, and detailed information on the tumor location and measurements before surgery (Figures, diagram, sizes) to precisely define the irradiation field during complementary radiotherapy.
  • [MeSH-major] Conjunctival Neoplasms / diagnosis. Conjunctival Neoplasms / therapy. Ophthalmology / methods
  • [MeSH-minor] Choristoma / diagnosis. Combined Modality Therapy. Diagnosis, Differential. Humans. Lymphoma / diagnosis. Melanoma / diagnosis. Neoplasm Staging. Neoplasms, Squamous Cell / diagnosis. Nevus / diagnosis. Papilloma / diagnosis. Pigmentation. Precancerous Conditions / diagnosis

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  • [Copyright] Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20096479.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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50. Robinson JW, Brownstein S, Jordan DR, Hodge WG: Conjunctival mucoepidermoid carcinoma in a patient with ocular cicatricial pemphigoid and a review of the literature. Surv Ophthalmol; 2006 Sep-Oct;51(5):513-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conjunctival mucoepidermoid carcinoma in a patient with ocular cicatricial pemphigoid and a review of the literature.
  • The woman was undergoing mitomycin C injections for ocular cicatricial pemphigoid, diagnosed in the same eye 2 years prior to identification of the neoplasm.
  • The tumor invaded the cornea, sclera, lacrimal gland, regional small nerves, and lymphatics, but did not show intraocular involvement.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Conjunctival Neoplasms / pathology. Conjunctivitis / complications. Pemphigoid, Benign Mucous Membrane / complications
  • [MeSH-minor] Basement Membrane / pathology. Biopsy. Drug Therapy, Combination. Female. Fluorometholone / therapeutic use. Humans. Middle Aged. Mitomycin / therapeutic use. Neoplasm Invasiveness. Ofloxacin / therapeutic use


51. Saornil MA, Becerra E, Méndez MC, Blanco G: [Conjunctival tumors]. Arch Soc Esp Oftalmol; 2009 Jan;84(1):7-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Tumores de la conjuntiva.
  • Conjunctival tumors are one of the most frequent of the eye and adnexa.
  • They comprise a large variety of conditions, from benign lesions such as nevus or papilloma, to malignant lesions such as epidermoid carcinoma or melanoma which may threaten visual function and the life of the patient.
  • Early diagnosis is essential for preventing ocular and systemic spread and to preserve visual function.
  • In this paper we review the clinical characteristics of the most frequent conjunctival tumors, and we discuss tumor management.
  • [MeSH-major] Conjunctival Neoplasms
  • [MeSH-minor] Carcinoma / pathology. Carcinoma / surgery. Conjunctival Diseases / pathology. Conjunctival Diseases / surgery. Eye Enucleation. Eye Evisceration. Hematologic Neoplasms / pathology. Hematologic Neoplasms / surgery. Humans. Melanoma / pathology. Melanoma / surgery. Neoplasm Invasiveness. Nevus / pathology. Nevus / surgery. Papilloma / pathology. Papilloma / surgery. Precancerous Conditions / pathology. Precancerous Conditions / surgery. Sarcoma / pathology. Sarcoma / surgery

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  • (PMID = 19173134.001).
  • [ISSN] 1989-7286
  • [Journal-full-title] Archivos de la Sociedad Española de Oftalmología
  • [ISO-abbreviation] Arch Soc Esp Oftalmol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 47
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52. Berman EL, Shields CL, Sagoo MS, Eagle RC Jr, Shields JA: Multifocal blue nevus of the conjunctiva. Surv Ophthalmol; 2008 Jan-Feb;53(1):41-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Blue nevus is a congenital benign melanocytic tumor that classically occurs in the skin and carries low potential for malignant transformation.
  • A 55-year-old Hispanic woman was found to have multiple darkly pigmented lesions on her left eye.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Nevus, Blue / pathology
  • [MeSH-minor] Biopsy. Cryosurgery / methods. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Melanoma / diagnosis. Middle Aged

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  • (PMID = 18191656.001).
  • [ISSN] 0039-6257
  • [Journal-full-title] Survey of ophthalmology
  • [ISO-abbreviation] Surv Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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53. Andonegui-Navarro J, Aranguren-Laflin M, Aliseda-Pérez-de-Madrid D, Rebollo-Aguayo A: [Asymptomatic vasoproliferative retinal tumor]. Arch Soc Esp Oftalmol; 2005 Nov;80(11):675-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Asymptomatic vasoproliferative retinal tumor].
  • [Transliterated title] Tumor vasoproliferativo de la retina asintomático.
  • PURPOSE/METHOD: A case of vasoproliferative retinal tumor is described.
  • RESULTS/CONCLUSIONS: Vasoproliferative retinal tumors are infrequent benign retinal lesions of gliovascular composition.
  • The differential diagnoses needing consideration are a retinal hemangioma associated with von Hippel-Lindau disease, an amelanotic choroidal melanoma and an ocular metastasis from a tumor elsewhere.
  • [MeSH-major] Retinal Neoplasms / pathology

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  • (PMID = 16311959.001).
  • [ISSN] 0365-6691
  • [Journal-full-title] Archivos de la Sociedad Española de Oftalmología
  • [ISO-abbreviation] Arch Soc Esp Oftalmol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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54. Lally DR, Shields JF, Shields CL, Marr BP, Shields JA: Pigmented free-floating vitreous cyst in a child. J Pediatr Ophthalmol Strabismus; 2008 Jan-Feb;45(1):47-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • An 8-year-old asymptomatic boy was referred for a pigmented fundus lesion in his left eye that was suspected to be a possible choroidal melanoma.
  • Visual acuity was 20/20 in each eye.
  • Ocular examination in the upright position revealed a pigmented lesion measuring 4 mm in diameter and 3 mm in thickness located inferior to the fovea.
  • Observation of the benign vitreous cyst was advised.
  • A free-floating pigmented cyst can resemble a pigmented intraocular tumor, particularly if it is immediately preretinal.
  • [MeSH-major] Cysts / diagnosis. Eye Diseases / diagnosis. Pigment Epithelium of Eye / pathology. Vitreous Body / pathology

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  • (PMID = 18286964.001).
  • [ISSN] 0191-3913
  • [Journal-full-title] Journal of pediatric ophthalmology and strabismus
  • [ISO-abbreviation] J Pediatr Ophthalmol Strabismus
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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55. Turell ME, Singh AD: Vascular tumors of the retina and choroid: diagnosis and treatment. Middle East Afr J Ophthalmol; 2010 Jul;17(3):191-200
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  • [Title] Vascular tumors of the retina and choroid: diagnosis and treatment.
  • The major vascular tumors of the retina include retinal capillary hemangioma, cavernous hemangioma of the retina, retinal vasoproliferative tumor, and racemose hemangiomatosis of the retina or Wyburn-Mason syndrome.
  • While classified as benign, visual symptoms secondary to exudative retinal detachment and a variety of other mechanisms are common and are a major source of long-term visual disability.
  • As ocular symptoms are often the most common presenting disease manifestation, the ophthalmologist plays an important role in accurate and early diagnosis.

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  • (PMID = 20844673.001).
  • [ISSN] 0975-1599
  • [Journal-full-title] Middle East African journal of ophthalmology
  • [ISO-abbreviation] Middle East Afr J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2934709
  • [Keywords] NOTNLM ; Cavernous Hemangioma / Choroidal Hemangioma / Retinal Capillary Hemangioma / Retinal Vasoproliferative Tumor / Wyburn–Mason Syndrome
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56. Kloek CE, Bilyk JR, Pribitkin EA, Rubin PA: Orbital decompression as an alternative management strategy for patients with benign tumors located at the orbital apex. Ophthalmology; 2006 Jul;113(7):1214-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Orbital decompression as an alternative management strategy for patients with benign tumors located at the orbital apex.
  • PURPOSE: Tumors located in the intraconal portion of the orbital apex, especially those inferior to the optic nerve, can be difficult to access surgically, carrying a significant risk of ocular morbidity.
  • The purpose of this study was to investigate outcomes in 5 patients with benign-appearing but symptomatic tumors located in the intraconal portion of the orbital apex in which orbital decompression was performed as an alternative management strategy to resection.
  • PARTICIPANTS: Five patients were diagnosed with a compressive optic neuropathy secondary to a benign-appearing tumor at the orbital apex.
  • None of the patients had the tumor biopsied or resected.
  • CONCLUSIONS: Orbital decompression is a therapeutic option for patients with compressive optic neuropathies from benign orbital apex tumors, offering potential improvement in optic nerve function while sparing morbidity from attempts at surgical resection.
  • [MeSH-major] Decompression, Surgical. Nerve Compression Syndromes / surgery. Optic Nerve Diseases / surgery. Orbit / surgery. Orbital Neoplasms / surgery

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  • [CommentIn] Ophthalmology. 2007 Mar;114(3):619-20; author reply 620-1 [17324707.001]
  • (PMID = 16815404.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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57. Bikmaz K, Mrak R, Al-Mefty O: Management of bone-invasive, hyperostotic sphenoid wing meningiomas. J Neurosurg; 2007 Nov;107(5):905-12
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  • OBJECT: The hyperostosis frequently associated with sphenoid wing meningiomas is actual invasion of bone by the tumor.
  • The intracranial portion of the tumor is usually thin with en plaque spread, and the tumor tends to invade the orbit through the superior orbital fissure.
  • Seventeen of the patients had the distinguishing characteristics of hyperostotic sphenoid wing meningiomas-extensive bone invasion, en plaque dural involvement, and a minimal intracranial mass with minimal orbital involvement.
  • Revision of the orbital reconstruction was required because of postoperative enophthalmos (two cases) or restricted postoperative ocular movement (one case).
  • These lesions are generally histologically benign.
  • [MeSH-major] Hyperostosis / pathology. Meningeal Neoplasms / pathology. Meningeal Neoplasms / surgery. Meningioma / surgery. Neoplasm Invasiveness / pathology. Orbit / pathology
  • [MeSH-minor] Adult. Aged. Dura Mater / surgery. Female. Follow-Up Studies. Humans. Ki-67 Antigen / analysis. Male. Middle Aged. Neoplasm Recurrence, Local. Receptors, Estrogen / analysis. Receptors, Progesterone / analysis. Treatment Outcome

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  • (PMID = 17977259.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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58. Murthy R, Honavar SG: Secondary vasoproliferative retinal tumor associated with Usher syndrome type 1. J AAPOS; 2009 Feb;13(1):97-8
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  • [Title] Secondary vasoproliferative retinal tumor associated with Usher syndrome type 1.
  • Vasoproliferative retinal tumors are benign tumors of unknown origin that generally affect healthy persons between their fourth and sixth decades and may lead to severe vision loss as a result of intraretinal hemorrhages and exudates.
  • We describe a case of unilateral vasoproliferative retinal tumor associated with retinitis pigmentosa in a patient with Usher syndrome type 1.


59. Song JJ, Finger PT, Kurli M, Wisnicki HJ, Iacob CE: Giant secondary conjunctival inclusion cysts: a late complication of strabismus surgery. Ophthalmology; 2006 Jun;113(6):1049.e1-2
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  • The patient's ocular history, ophthalmic examinations, and imaging (ultrasound/ultrasound biomicroscopy and/or computed tomography) were recorded.
  • Histopathologic evaluations were consistent with benign inclusion cysts of the conjunctiva.
  • Tumor size, cystic nature, and involvement of underlying structures can be determined by ultrasonography and radiographic imaging.

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  • (PMID = 16631253.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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60. Soong T, Soong V, Salvi SM, Raynor M, Mudhar H, Goel S, Edwards M: Primary corneal myxoma. Cornea; 2008 Dec;27(10):1186-8
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  • These include an inferonasal location between the corneal epithelium and Bowman layer and with no relationship to the corneal stroma, rapid tumor growth over a 3-month period, and no previous ocular trauma or conjunctival pathology.
  • The histology of this lesion has an important part to play in the management of this condition as it determines the cellular origin, establishes a benign or malignant state, and helps with treatment and prognosis.
  • [MeSH-major] Corneal Diseases / pathology. Corneal Diseases / surgery. Eye Neoplasms / pathology. Eye Neoplasms / surgery. Myxoma / pathology. Myxoma / surgery

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  • (PMID = 19034139.001).
  • [ISSN] 1536-4798
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Thanou-Stavraki A, James JA: Primary Sjogren's syndrome: current and prospective therapies. Semin Arthritis Rheum; 2008 Apr;37(5):273-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Relevant English and non-English articles acquired through Medline were reviewed.
  • RESULTS: pSS usually has a benign clinical course, centered on sicca features and general musculoskeletal manifestations, and is managed symptomatically.
  • Muscarinic agonists and topical cyclosporine yield well-documented improvement in ocular sicca features.
  • Among the biologic agents already examined in pSS, those targeting tumor necrosis factor (TNF)-alpha failed to demonstrate significant benefit.

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  • (PMID = 17714766.001).
  • [ISSN] 0049-0172
  • [Journal-full-title] Seminars in arthritis and rheumatism
  • [ISO-abbreviation] Semin. Arthritis Rheum.
  • [Language] ENG
  • [Grant] United States / NIAMS NIH HHS / AR / AR49084; United States / NIAID NIH HHS / AI / AI31584; United States / NCRR NIH HHS / RR / RR15577; United States / NIAMS NIH HHS / AR / AR45084; United States / NIAMS NIH HHS / AR / P30 AR053483; United States / NCRR NIH HHS / RR / RR20143; United States / NIAMS NIH HHS / AR / AR48045; United States / NIAMS NIH HHS / AR / AR48940
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antirheumatic Agents; 0 / Immunologic Factors; 0 / Tumor Necrosis Factor-alpha
  • [Number-of-references] 251
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62. Arathi C, Vijaya C: Scrape cytology in the early diagnosis of eyelid sebaceous carcinoma. J Cytol; 2010 Oct;27(4):140-2
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  • [Title] Scrape cytology in the early diagnosis of eyelid sebaceous carcinoma.
  • The low incidence and the non-specific clinical symptoms led us to conclude that the diagnosis of a sebaceous carcinoma of the eyelid often occurs very late.
  • Sebaceous carcinoma of the ocular adnexa is a malignant neoplasm which can exhibit aggressive local behavior, can have pagetoid spread and can metastasize to regional lymph nodes and distant organs.
  • The neoplasm is known to masquerade as other benign and less malignant lesions, and has relatively high morbidity and mortality.
  • Scrape cytology was done in a 70-year-old female with a tumor in left upper lid.
  • Subsequently, histopathology confirmed the diagnosis of sebaceous gland carcinoma.
  • The article highlights the role of scrape cytology in early diagnosis and subsequent appropriate surgical management of eyelid sebaceous gland carcinoma, to prevent recurrence and metastasis.

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  • (PMID = 21157566.001).
  • [ISSN] 0974-5165
  • [Journal-full-title] Journal of cytology
  • [ISO-abbreviation] J Cytol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3001202
  • [Keywords] NOTNLM ; Sebaceous carcinoma / eyelid / scrape cytology
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63. Khuu T, Hoffman DJ: Circumscribed choroidal hemangioma: A case report and review of the literature. Optometry; 2006 Aug;77(8):384-91
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  • BACKGROUND: Choroidal hemangioma is a rare, benign vascular ocular tumor that presents as either a circumscribed mass or as a diffuse variant.
  • CASE REPORT: A 35-year-old Hispanic man presented for a routine eye examination and was observed to have a choroidal lesion in the posterior pole.
  • The lesion is an elevated subretinal mass located superotemporal to the fovea in the right eye.
  • A selective battery of diagnostic tests will facilitate the correct diagnosis.
  • Management of CCH may depend on the character of the lesion and risks of ocular morbidity and vision loss.
  • [MeSH-major] Choroid Neoplasms / diagnosis. Hemangioma / diagnosis
  • [MeSH-minor] Adult. Choroid / pathology. Choroid / ultrasonography. Diagnosis, Differential. Fluorescein Angiography. Follow-Up Studies. Fundus Oculi. Humans. Male. Visual Field Tests

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  • (PMID = 16877203.001).
  • [ISSN] 1529-1839
  • [Journal-full-title] Optometry (St. Louis, Mo.)
  • [ISO-abbreviation] Optometry
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Schöniger S, Summers BA: Localized, plexiform, diffuse, and other variants of neurofibroma in 12 dogs, 2 horses, and a chicken. Vet Pathol; 2009 Sep;46(5):904-15
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  • In humans, neurofibroma and schwannoma are distinct entities within the group of benign peripheral nerve sheath tumors.
  • In the veterinary literature, these tumors are often classified together simply as benign peripheral nerve sheath tumors, and diagnostic criteria for their subclassification are not well established.
  • The chicken was a mature white Leghorn chicken with an ocular neoplasm.
  • This investigation shows the existence of identical subtypes of neurofibroma in animals and humans and identifies similarities in tumor location and patient age between animals and humans.
  • This report will allow a more discriminating classification of benign peripheral nerve sheath tumors and probably has a bearing on epidemiology, pathogenesis and prognosis.

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  • (PMID = 19429995.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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65. John H, Whallett A, Quinlan M: Successful biologic treatment of ocular mucous membrane pemphigoid with anti-TNF-alpha. Eye (Lond); 2007 Nov;21(11):1434-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Successful biologic treatment of ocular mucous membrane pemphigoid with anti-TNF-alpha.
  • [MeSH-major] Conjunctival Diseases / drug therapy. Immunoglobulin G / therapeutic use. Immunosuppressive Agents / therapeutic use. Pemphigoid, Benign Mucous Membrane / drug therapy. Receptors, Tumor Necrosis Factor / therapeutic use. Tumor Necrosis Factor-alpha / antagonists & inhibitors

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  • (PMID = 17693996.001).
  • [ISSN] 0950-222X
  • [Journal-full-title] Eye (London, England)
  • [ISO-abbreviation] Eye (Lond)
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Immunoglobulin G; 0 / Immunosuppressive Agents; 0 / Receptors, Tumor Necrosis Factor; 0 / Tumor Necrosis Factor-alpha; OP401G7OJC / Etanercept
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66. Ushio M, Murofushi T, Iwasaki S: Subjective visual horizontal in patients with posterior canal benign paroxysmal positional vertigo. Acta Otolaryngol; 2007 Aug;127(8):836-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Subjective visual horizontal in patients with posterior canal benign paroxysmal positional vertigo.
  • CONCLUSION: Patients with posterior canal benign paroxysmal positional vertigo (p-BPPV) could have mild excitation in the vestibular system on the affected side.
  • For comparison, 17 patients with vestibular neuritis and 45 patients with cerebello-pontine angle (CPA) tumor were also examined.
  • Conversely, deviation of SVH was toward the affected side down in 88.2% of patients with vestibular neuritis and in 75.6% of patients with CPA tumor.
  • [MeSH-major] Posture / physiology. Reflex, Vestibulo-Ocular / physiology. Vertigo / physiopathology. Vision, Ocular / physiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cerebellar Neoplasms / complications. Cerebellar Neoplasms / physiopathology. Cerebellopontine Angle. Female. Follow-Up Studies. Humans. Male. Middle Aged. Severity of Illness Index. Vestibular Neuronitis / complications. Vestibular Neuronitis / physiopathology


67. Kreusel KM: Ophthalmological manifestations in VHL and NF 1: pathological and diagnostic implications. Fam Cancer; 2005;4(1):43-7
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  • Von Hippel-Lindau disease (VHL) and neurofibromatosis type 1 (NF 1) are hereditary multitumor syndromes that show associated ocular manifestations.
  • Capillary retinal angioma, a benign vascular tumor, is the classical ocular lesion in VHL.
  • It often appears as the first manifestation of the disease and may thus lead to the diagnosis of VHL.
  • Since small angiomas can be treated easily by laser photocoagulation, a regular ocular screening of VHL patients is recommended.
  • Ocular manifestations of NF 1 are more diverse as compared to VHL.
  • Extension of the tumor beyond the chiasm worsens the prognosis quoad vitam.
  • [MeSH-major] Hemangioma / etiology. Neurofibromatosis 1 / complications. Neurofibromatosis 1 / diagnosis. Optic Nerve Glioma / etiology. Retinal Neoplasms / etiology. von Hippel-Lindau Disease / complications. von Hippel-Lindau Disease / diagnosis

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  • (PMID = 15883709.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 63
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68. Vijayalakshmi P, Jethani J, Kim U: Congenital unilateral ocular fibrosis syndrome secondary to benign congenital tumor. Indian J Ophthalmol; 2006 Jun;54(2):123-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Congenital unilateral ocular fibrosis syndrome secondary to benign congenital tumor.
  • We report a case of this rare syndrome associated with an adjacent sinus tumor.
  • [MeSH-major] Oculomotor Muscles / pathology. Orbital Neoplasms / complications
  • [MeSH-minor] Diagnosis, Differential. Female. Fibrosis / congenital. Fibrosis / etiology. Fibrosis / pathology. Humans. Infant. Magnetic Resonance Imaging

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  • (PMID = 16770032.001).
  • [ISSN] 0301-4738
  • [Journal-full-title] Indian journal of ophthalmology
  • [ISO-abbreviation] Indian J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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69. Sokol JA, Clark JD, Lee HB, Nunery WR: Pigmented epithelioid melanocytoid tumor of the ocular adnexa. J Pediatr Ophthalmol Strabismus; 2010;47 Online:e1-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pigmented epithelioid melanocytoid tumor of the ocular adnexa.
  • An 8-year-old girl with a history of microphthalmia in the right eye presented with a left medial upper eyelid mass with a dark blue-green nodule that could be seen through the skin but did not appear to involve the overlying epidermis.
  • A biopsy demonstrated a pigmented epithelioid melanocytoid tumor with rare mitoses arising in association with a congenital nevus and positive margins.
  • Due to the pathological findings, the patient underwent excision of the tumor with 5-mm margins and a sentinel lymph node biopsy.
  • The re-excision of the upper eyelid margins demonstrated residual benign congenital melanocytic nevus, but did not reveal residual melanocytic lesion.
  • The parotid sentinel node biopsy revealed benign and cytologically mature nevus nests in the capsule and septa, but there was no evidence of involvement with the pigmented epithelioid melanocytoid tumor.
  • [MeSH-major] Eyelid Neoplasms / pathology. Nevus, Epithelioid and Spindle Cell / pathology. Skin Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Skin Cancer.
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  • [Copyright] Copyright 2010, SLACK Incorporated.
  • (PMID = 21162462.001).
  • [ISSN] 1938-2405
  • [Journal-full-title] Journal of pediatric ophthalmology and strabismus
  • [ISO-abbreviation] J Pediatr Ophthalmol Strabismus
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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