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1. Kiratli H, Yildiz S, Soylemezoğlu F: Neurofibromatosis type 2: optic nerve sheath meningioma in one orbit, intramuscular schwannoma in the other. Orbit; 2008;27(6):451-4
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  • [Title] Neurofibromatosis type 2: optic nerve sheath meningioma in one orbit, intramuscular schwannoma in the other.
  • Magnetic resonance imaging studies showed bilateral cerebellopontine angle tumors, a tumor surrounding the right intraorbital optic nerve, and a large left lateral orbital mass mixed with the lateral rectus muscle.
  • The histopathological diagnoses following incisional biopsies were right optic nerve sheath meningioma and left intramuscular schwannoma.
  • The left-sided orbital schwannoma and the right-sided vestibular schwannoma were treated with fractionated stereotactic radiotherapy.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningioma / pathology. Muscle Neoplasms / pathology. Neoplasms, Second Primary / pathology. Neurilemmoma / pathology. Neurofibromatosis 2 / pathology. Orbital Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Child. Female. Functional Laterality. Hamartoma / pathology. Humans. Magnetic Resonance Imaging. Neoplasm Proteins / analysis. Neuroma, Acoustic / chemistry. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Oculomotor Muscles / pathology. Radiosurgery. Radiotherapy, Conformal. Retinal Diseases / pathology


2. Ulu EM, Cakmak O, Dönmez FY, Büyüklü F, Cevik B, Akdoğan V, Coşkun M: Sinonasal schwannoma of the middle turbinate. Diagn Interv Radiol; 2010 Jun;16(2):129-31
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  • [Title] Sinonasal schwannoma of the middle turbinate.
  • Paranasal schwannomas are uncommon lesions, representing less than 4% of all head and neck schwannomas.
  • Here, we present the radiologic features of a benign schwannoma of the middle turbinate with dural invasion in a 71-year-old woman.
  • [MeSH-major] Neurilemmoma / radiography. Nose Neoplasms / radiography. Paranasal Sinus Neoplasms / radiography. Turbinates / radiography

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  • (PMID = 19821257.001).
  • [ISSN] 1305-3612
  • [Journal-full-title] Diagnostic and interventional radiology (Ankara, Turkey)
  • [ISO-abbreviation] Diagn Interv Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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3. Lai D, Li WR, Wu YJ: [One case of neurilemmoma resection on infratemporal fossa through left maxillary sinus route guided by endoscopic]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2005 Jun;40(6):472
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  • [Title] [One case of neurilemmoma resection on infratemporal fossa through left maxillary sinus route guided by endoscopic].
  • [MeSH-major] Endoscopy. Neurilemmoma / surgery. Paranasal Sinus Neoplasms / surgery

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  • (PMID = 16144354.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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4. Colletti V: Auditory outcomes in tumor vs. nontumor patients fitted with auditory brainstem implants. Adv Otorhinolaryngol; 2006;64:167-85
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  • [Title] Auditory outcomes in tumor vs. nontumor patients fitted with auditory brainstem implants.
  • Auditory brainstem implants (ABIs) are currently indicated for patients older than 12 years with neurofibromatosis type 2 (NF2) who had bilateral schwannoma removed.
  • Over the last 10 years, we have extended the indications for ABIs to nontumor children and adult patients with cochlear or cochlear nerve injuries or malfunctions who would not benefit from a cochlear implant.
  • In the present chapter we report our recent findings in adult ABI patients and compare the psychophysical and speech perception outcomes in tumor with those in nontumor patients.
  • We demonstrate that the ABI can stimulate the central auditory system in a way that gives the ability of open set speech understanding, and can thus be indicated in nontumor adult patients who are not candidates for a cochlear implant.
  • Twenty-six patients had NF2 with bilateral vestibular schwannoma removal, and 54 had nontumor diseases of the cochlear nerve or cochlea.
  • At 1 year after implantations nontumor adults scored from 12 to 100% in open set speech perception tests (average 59%), and tumor (NF2) patients scored from 5 to 30% (average of 11%).
  • To investigate the cause of the differences in performance between tumor and nontumor ABI recipients, a series of psychophysical tests were done consecutively in 39 adult patients with implants (25 nontumor and 14 tumor patients) from May 1999 to April 2004 and with a follow-up of at least 1 year.
  • (1) The ABIs allow most tumor and nontumor patients to experience improved communication as well as awareness of environmental sounds. (2) Nontumor patients had better hearing outcomes than tumor patients when the variation in the auditory benefit with the ABI in relation to the patient's underlying pathological conditions were taken into consideration. (3) A significant number of nontumor patients are able understand speech at a level comparable to that of the most successful cochlear implant users including conversational telephone use. (4) The ABI represents the tool for hearing rehabilitation in patients with profound hearing loss who cannot be fitted with cochlear implants.
  • [MeSH-major] Auditory Brain Stem Implants. Ear Neoplasms / surgery. Hearing Loss / surgery. Neurilemmoma / surgery. Neurofibromatosis 2 / surgery

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  • (PMID = 16891842.001).
  • [ISSN] 0065-3071
  • [Journal-full-title] Advances in oto-rhino-laryngology
  • [ISO-abbreviation] Adv. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 38
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5. Preuss M, Stein M, Huegens-Penzel M, Kuchelmeister K, Nestler U: Metastatic tumours mimicking vestibular schwannoma. Acta Neurochir (Wien); 2008 Sep;150(9):915-9
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  • [Title] Metastatic tumours mimicking vestibular schwannoma.
  • In this review of the literature we discuss the rare occurrence of metastatic tumours mimicking bilateral vestibular schwannoma and present an own case with pancreatic signet-ring cell carcinoma as primary tumour.
  • [MeSH-major] Carcinoma, Signet Ring Cell / diagnosis. Carcinoma, Signet Ring Cell / secondary. Ear Neoplasms / diagnosis. Ear Neoplasms / secondary. Ear, Inner. Neuroma, Acoustic / diagnosis. Pancreatic Neoplasms / pathology

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  • (PMID = 18754073.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 34
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6. Hadfield KD, Smith MJ, Urquhart JE, Wallace AJ, Bowers NL, King AT, Rutherford SA, Trump D, Newman WG, Evans DG: Rates of loss of heterozygosity and mitotic recombination in NF2 schwannomas, sporadic vestibular schwannomas and schwannomatosis schwannomas. Oncogene; 2010 Nov 25;29(47):6216-21
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  • [Title] Rates of loss of heterozygosity and mitotic recombination in NF2 schwannomas, sporadic vestibular schwannomas and schwannomatosis schwannomas.
  • Biallelic inactivation of the NF2 gene occurs in the majority of schwannomas.
  • We have performed DNA sequence and dosage analysis of the NF2 gene in a panel of 239 schwannoma tumours: 97 neurofibromatosis type 2 (NF2)-related schwannomas, 104 sporadic vestibular schwannomas (VS) and 38 schwannomatosis-related schwannomas.
  • LOH was present in 28 out of 34 (82%) schwannomatosis-related schwannomas.
  • In all eight patients who had previously tested positive for a germline SMARCB1 mutation, this involved loss of the whole, or part of the long arm, of chromosome 22.
  • This study shows that MR is a mechanism of LOH in NF2 and SMARCB1-negative schwannomatosis-related schwannomas, occurring less frequently in sporadic vs. We found no evidence of MR in SMARCB1-positive schwannomatosis, suggesting that susceptibility to MR varies according to the disease context.
  • [MeSH-minor] Adolescent. Adult. Child. Chromosome Breakpoints. Gene Dosage / genetics. Genes, Neurofibromatosis 2. Homozygote. Humans. Neurilemmoma / genetics. Neurofibromatoses / genetics. Polymorphism, Single Nucleotide / genetics. Skin Neoplasms / genetics. Young Adult

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  • (PMID = 20729918.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] Schwannomatosis
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7. Nagano O, Higuchi Y, Serizawa T, Ono J, Matsuda S, Yamakami I, Saeki N: Transient expansion of vestibular schwannoma following stereotactic radiosurgery. J Neurosurg; 2008 Nov;109(5):811-6
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  • [Title] Transient expansion of vestibular schwannoma following stereotactic radiosurgery.
  • OBJECT: The authors prospectively analyzed volume changes in vestibular schwannomas (VSs) after stereotactic radiosurgery.
  • The frequency and degree of transient tumor expansion were documented and possible prognostic factors were analyzed.
  • Tumor volumes at GKS averaged 2.7 cm3 (range 0.1-13.2 cm3), and the lesions were irradiated at the mean 52.2% isodose line for the tumor margin (range 50-67%), with a mean dose of 12.2 Gy (range 10.5-13 Gy) at the periphery.
  • The tumor volume was increased by 23% at 3 months and 27% at 6 months.
  • The peak tumor expansion averaged 47% (range 0-613%).
  • A high-dose (> or = 3.5 Gy/min) treatment appears to be the greatest risk factor for transient tumor expansion, although the difference did not reach statistical significance.
  • Transient facial palsy and facial dysesthesia correlated strongly with tumor expansion, but only half of the hearing loss was coincident with this phenomenon.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cranial Nerves / physiopathology. Facial Nerve / physiopathology. Female. Humans. Male. Middle Aged. Prospective Studies. Risk Factors. Treatment Outcome. Trigeminal Nerve / physiopathology. Tumor Burden

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  • (PMID = 18976069.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Plotkin SR, Halpin C, McKenna MJ, Loeffler JS, Batchelor TT, Barker FG 2nd: Erlotinib for progressive vestibular schwannoma in neurofibromatosis 2 patients. Otol Neurotol; 2010 Sep;31(7):1135-43
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  • [Title] Erlotinib for progressive vestibular schwannoma in neurofibromatosis 2 patients.
  • We sought to determine the activity of erlotinib for progressive vestibular schwannoma (VS) associated with neurofibromatosis 2 (NF2).
  • PATIENTS: Eleven NF2 patients with progressive VS who were poor candidates for standard therapy.
  • MAIN OUTCOME MEASURES: A radiographic response was defined as >or= 20% decrease in tumor volume compared with baseline.
  • Among 10 evaluable patients, the median time-to-tumor progression was 9.2 months.
  • Three patients with stable disease experienced maximum tumor shrinkage of 4%, 13%, and 14%.
  • The median time-to-progressive hearing loss was 9.2 months and to either tumor growth or progressive hearing loss was 7.1 months.
  • Adverse treatment effects included mild-to-moderate rash, diarrhea, and hair thinning, with 2 episodes of grade 3 toxicity.
  • CONCLUSION: Erlotinib treatment was not associated with radiographic or hearing responses in NF2 patients with progressive vs. Because a subset of patients experienced prolonged stable disease, time-to-progression may be more appropriate than radiographic or hearing response for anti-EGFR agents in NF2-associated vs.
  • [MeSH-minor] Adolescent. Adult. Audiometry, Pure-Tone. Disease Progression. Erlotinib Hydrochloride. Female. Hearing Loss, Sensorineural / complications. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Speech Perception / physiology. Treatment Outcome. Young Adult

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  • (PMID = 20736812.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / P01 NS024279; United States / NINDS NIH HHS / NS / P01 NS024279-23; United States / NIDCD NIH HHS / DC / R01 DC009837
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Quinazolines; DA87705X9K / Erlotinib Hydrochloride
  • [Other-IDs] NLM/ NIHMS570073; NLM/ PMC4030413
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9. Watanabe T, Nagase K, Chosa M, Tobinai K: Schwann cell autophagy induced by SAHA, 17-AAG, or clonazepam can reduce bortezomib-induced peripheral neuropathy. Br J Cancer; 2010 Nov 9;103(10):1580-7
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  • [Title] Schwann cell autophagy induced by SAHA, 17-AAG, or clonazepam can reduce bortezomib-induced peripheral neuropathy.
  • Animal studies suggest that bortezomib predominantly causes pathological changes in Schwann cells.
  • METHODS: Rat schwannoma cells were pretreated with vincristine (VCR), histone deacetylase inhibitors, anticonvulsants, or a heat-shock protein 90 (HSP90) inhibitor.
  • CONCLUSIONS: This schwannoma model can be used to test BiPN-reducing drugs.
  • The present data suggest that aggresome formation in Schwann cells is a possible mechanism of BiPN, and drugs that induce HSP70 or LAMP-2A have the potential to alleviate this complication.
  • [MeSH-minor] Animals. Antineoplastic Agents / therapeutic use. Boronic Acids / therapeutic use. Bortezomib. Cell Division / drug effects. Cell Line, Tumor. HSP90 Heat-Shock Proteins / antagonists & inhibitors. Multiple Myeloma / drug therapy. Multiple Myeloma / pathology. Neurilemmoma. Protein Folding. Proteostasis Deficiencies / pathology. Pyrazines / therapeutic use. Rats. Schwann Cells / cytology. Schwann Cells / pathology

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  • (PMID = 20959823.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzoquinones; 0 / Boronic Acids; 0 / HSP90 Heat-Shock Proteins; 0 / Lactams, Macrocyclic; 0 / Pyrazines; 4GY0AVT3L4 / tanespimycin; 5PE9FDE8GB / Clonazepam; 69G8BD63PP / Bortezomib
  • [Other-IDs] NLM/ PMC2990589
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10. El-Bahrawy M, Khoubehi B, Hrouda D: Perirenal schwannoma: a case report. J Med Case Rep; 2008;2:189
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  • [Title] Perirenal schwannoma: a case report.
  • CASE PRESENTATION: We describe the case of a tumour presenting towards the lateral border of the ventral aspect of the mid-zone of the kidney.
  • This was a spindle cell lesion in which the cells strongly and diffusely expressed cytokeratins, but were negative for epithelial membrane antigen.
  • The cells also expressed S-100 protein and glial fibrillary acidic protein, confirming the diagnosis of a cellular schwannoma.
  • CONCLUSION: To the best of our knowledge, this is the first case of a cellular schwannoma presenting towards the lateral border of the kidney.
  • The case also highlights the importance of using a panel of antibodies in diagnosing spindle cell neoplasms in the kidney.

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  • [Cites] Eur Radiol. 2001;11(9):1834-7 [11511910.001]
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  • (PMID = 18518995.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2430707
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11. Sabat SB, Chapman P, Pappas DG: Radiology quiz case 2. Hemorrhagic vestibular schwannoma. Arch Otolaryngol Head Neck Surg; 2010 Aug;136(8):837-9
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  • [Title] Radiology quiz case 2. Hemorrhagic vestibular schwannoma.


12. Nishio M, Tamaki T, Hara M, Shibamoto Y: Appendiceal schwannoma detected by FDG-PET/CT. Clin Nucl Med; 2010 May;35(5):379-80
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  • [Title] Appendiceal schwannoma detected by FDG-PET/CT.
  • [MeSH-major] Appendiceal Neoplasms / radiography. Appendiceal Neoplasms / radionuclide imaging. Fluorodeoxyglucose F18. Neurilemmoma / radiography. Neurilemmoma / radionuclide imaging. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 20395722.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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13. Mandrioli L, Gentile A, Morini M, Bettini G, Marcato PS: Malignant, solitary, nasopharyngeal schwannoma in a cow. Vet Rec; 2005 Apr 23;156(17):552-3
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  • [Title] Malignant, solitary, nasopharyngeal schwannoma in a cow.
  • [MeSH-major] Cattle Diseases / diagnosis. Nasopharyngeal Neoplasms / veterinary. Neurilemmoma / veterinary

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  • (PMID = 15849348.001).
  • [ISSN] 0042-4900
  • [Journal-full-title] The Veterinary record
  • [ISO-abbreviation] Vet. Rec.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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14. Flickinger JC, Burton S: Radiotherapy of cranial nerve schwannomas. Prog Neurol Surg; 2008;21:238-46
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  • [Title] Radiotherapy of cranial nerve schwannomas.
  • Fractionated stereotactic radiotherapy is an attractive, low-morbidity alternative to surgical resection for managing cranial nerve schwannomas.
  • [MeSH-major] Cranial Nerve Neoplasms / radiotherapy. Neurilemmoma / radiotherapy

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  • (PMID = 18810225.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 15
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15. Vellin JF, Bozorg Grayeli A, Kalamarides M, Fond C, Bouccara D, Sterkers O: Intratumoral and brainstem hemorrhage in a patient with vestibular schwannoma and oral anticoagulant therapy. Otol Neurotol; 2006 Feb;27(2):209-12
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  • [Title] Intratumoral and brainstem hemorrhage in a patient with vestibular schwannoma and oral anticoagulant therapy.
  • OBJECTIVE: To report the first case of spontaneous intratumoral and brainstem hemorrhage in a patient with a vestibular schwannoma.
  • PATIENT: A 73-year-old woman with a vestibular schwannoma, anti-vitamin K overdose, and arterial hypertension experienced a rapid onset of headache, facial palsy, diplopia, and hoarseness.
  • CONCLUSION: Intratumoral, subarachnoid, and brainstem hemorrhages can occur in patients with vestibular schwannoma.
  • Oral anticoagulant therapy is a risk factor for tumor-related hemorrhage.

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  • (PMID = 16436991.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticoagulants
  • [Number-of-references] 14
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16. Chung WY, Liu KD, Shiau CY, Wu HM, Wang LW, Guo WY, Ho DM, Pan DH: Gamma knife surgery for vestibular schwannoma: 10-year experience of 195 cases. J Neurosurg; 2005 Jan;102 Suppl:87-96
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  • [Title] Gamma knife surgery for vestibular schwannoma: 10-year experience of 195 cases.
  • OBJECT: The authors conducted a study to determine the optimal radiation dose for vestibular schwannoma (VS) and to examine the histopathology in cases of treatment failure for better understanding of the effects of irradiation.
  • Seventy-two patients (37%) had undergone partial or total excision of their tumor prior to gamma knife surgery (GKS).
  • The mean tumor volume was 4.1 cm3 (range 0.04-23.1 cm3).
  • Multiisocenter dose planning placed a prescription dose of 11 to 18.2 Gy on the 50 to 94% isodose located at the tumor margin.
  • At the latest MR imaging assessment decreased or stable tumor volume was demonstrated in 93.6% of the patients.
  • Uncontrolled tumor swelling was noted in five patients at 3.5, 17, 24, 33, and 62 months after GKS, respectively.
  • Histopathological examination of specimens in three cases (one at 62 months after GKS) revealed a long-lasting radiation effect on vessels inside the tumor.
  • A margin 12-Gy dose with homogeneous distribution is effective in preventing tumor progression, while posing no serious threat to normal cranial nerve function.

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  • (PMID = 15662787.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents
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17. Kralick F, Koenigsberg R: Sciatica in a patient with unusual peripheral nerve sheath tumors. Surg Neurol; 2006 Dec;66(6):634-7
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  • BACKGROUND: Other causes such as peripheral schwannomas can mimic lumbar disk disease.
  • Magnetic resonance neurography subsequently revealed a compressive mass of the sciatic nerve proximal to the popliteal fossa, histologically identified as a schwannoma.
  • [MeSH-major] Myelin Sheath / pathology. Neurilemmoma / complications. Neurilemmoma / pathology. Peripheral Nervous System Neoplasms / complications. Peripheral Nervous System Neoplasms / pathology. Sciatica / etiology

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  • (PMID = 17145335.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Rogg JM, Ahn SH, Tung GA, Reinert SE, Norén G: Prevalence of hydrocephalus in 157 patients with vestibular schwannoma. Neuroradiology; 2005 May;47(5):344-51
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  • [Title] Prevalence of hydrocephalus in 157 patients with vestibular schwannoma.
  • The purpose of this study was to determine the prevalence of hydrocephalus in patients with vestibular schwannoma.
  • A second objective was to investigate possible etiologies for hydrocephalus in this population by attempting to correlate the incidence and severity of hydrocephalus with tumor volume and extent of fourth ventricular compression.
  • The MRI examinations of 157 adult patients with vestibular schwannoma were retrospectively reviewed.
  • Tumor size was quantified, and the presence of accompanying hydrocephalus was assessed, categorized as communicating type or non-communicating type and then rated as mild, moderate or severe (grades 1-3).
  • Next, the degree of fourth ventricular distortion caused by tumor mass effect was evaluated and categorized as mild, moderate or severe (grades 1-3).
  • Spearman's rank correlation coefficient was used to test the relationships between tumor volume and (1) the extent of fourth ventricular effacement and (2) severity of hydrocephalus.
  • There was a positive correlation between the grade of non-communicating hydrocephalus and tumor volume (r=0.38; P<0.001) and between the severity of fourth ventricular compression and extent of hydrocephalus in this group(r=0.43; P<0.001).
  • In patients who were classified as having communicating hydrocephalus, the correlation between tumor volume and the severity of hydrocephalus was poor (r=0.19; P=0.02) as was the correlation between the extent of fourth ventricular distortion and the severity of hydrocephalus (r=0.21; P<0.01).
  • There is a high prevalence of hydrocephalus in patients with vestibular schwannoma.
  • In a minority of cases non-communicating type hydrocephalus is present and the severity of hydrocephalus can be attributed to the affect of tumor volume on fourth ventricular compression.
  • Therefore, other etiologies for hydrocephalus, such as tumor protein sloughing, are likely relevant.


19. Hascalik S, Celik O, Erdem G, Ara C, Kirimlioglu H: Proton magnetic resonance spectroscopy findings of a sacrococcygeal schwannoma. Int J Gynecol Cancer; 2006 Jan-Feb;16 Suppl 1:344-8
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  • [Title] Proton magnetic resonance spectroscopy findings of a sacrococcygeal schwannoma.
  • Schwannoma is tumor of peripheral nerves, originating from Schwann cells.
  • It is a rare nerve sheath tumor, which frequently occurs in the intracranial acoustic nerve and spinal nerves.
  • We report on a 28-year-old woman who suffered from a large pelvic mass that was diagnosed to be sacrococcygeal schwannoma.
  • MRS measurement was performed on two different parts of the tumor.
  • As well as strongly elevated choline and lipid signals, the tumor spectrum showed increased N-acetylaspartate resonances.
  • [MeSH-major] Magnetic Resonance Spectroscopy. Nerve Sheath Neoplasms / chemistry. Nerve Sheath Neoplasms / diagnosis. Neurilemmoma / chemistry. Neurilemmoma / diagnosis

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  • Hazardous Substances Data Bank. (L)-ASPARTIC ACID .
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  • (PMID = 16515619.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Lipids; 0 / Protons; 30KYC7MIAI / Aspartic Acid; N91BDP6H0X / Choline
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20. Park MK, Lee KT, Choi YS, Shin DH, Lee JY, Lee JK, Paik SW, Ko YH, Rhee JC: [A case of benign schwannoma in the porta hepatis]. Korean J Gastroenterol; 2006 Feb;47(2):164-7
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  • [Title] [A case of benign schwannoma in the porta hepatis].
  • Schwannomas or neurilemmomas are uncommon tumors arising from schwann cells of neural sheath, which most frequently affect the extremities, trunk, head and neck area.
  • Moreover, benign schwannoma in the porta hepatis is extremely rare.
  • Approximately, 2 cases of benign schwannoma in the porta hepatis have been reported in the literatures.
  • We report a case of benign schwannoma in the porta hepatis occurring in a 53-year-old woman who was asymptomatic and incidentally found to have a mass.
  • [MeSH-major] Liver Neoplasms. Neurilemmoma

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  • (PMID = 16498284.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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21. Wang ZM, Xu WQ: [Analysis of prognostic factors in microsurgery of intratemporal facial nerve schwannoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2007 Jan;42(1):30-2
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  • [Title] [Analysis of prognostic factors in microsurgery of intratemporal facial nerve schwannoma].
  • OBJECTIVE: To discuss prognostic factors in microsurgery of intratemporal facial nerve schwannoma.
  • METHODS: Clinical and follow-up materials from 13 cases of facial nerve schwannoma were analyzed retrospectively.
  • Mann-Whitney U test showed that the tumor position had no effect on the postoperative facial nerve function (P = 0.889).
  • CONCLUSIONS: Among most of the patients who received microsurgery of facial nerve schwannoma, facial nerve functions could be restored to great extent.
  • The longer the preoperative duration of facial nerve paralysis or the worse the preoperative facial nerve function, the worse the postoperative facial nerve function in cases who received facial nerve resection and reconstruction.
  • Facial nerve reconstruction was helpful for the patient with facial nerve schwannoma whose facial muscles were denervated but have fibrillation potentials, as well as for the patient whose facial nerve schwannoma intruded internal acoustic canal.
  • [MeSH-major] Facial Neoplasms / diagnosis. Facial Nerve / pathology. Microsurgery. Neurilemmoma / diagnosis

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  • (PMID = 17432353.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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22. Cayé-Thomasen P, Borup R, Stangerup SE, Thomsen J, Nielsen FC: Deregulated genes in sporadic vestibular schwannomas. Otol Neurotol; 2010 Feb;31(2):256-66
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  • [Title] Deregulated genes in sporadic vestibular schwannomas.
  • OBJECTIVE: In search of genes associated with vestibular schwannoma tumorigenesis, this study examines the gene expression in human vestibular nerve versus vestibular schwannoma tissue samples using microarray technology.
  • MATERIAL AND METHODS: RNA was extracted from 3 vestibular nerves (serving as control) and 16 solid, sporadic vestibular schwannomas.
  • Differentially expressed genes were identified as differences between control and tumor tissue larger than 2-fold, with a conservative p value of less than 0.000161 and means of differences greater than 25.
  • RESULTS: Eighty-seven probe sets, representing 78 genes, were significantly up- or down-regulated in tumor tissue.
  • The deregulated genes were matched against established gene ontology, revealing that 8 of the up-regulated genes are involved in regulation of the cell cycle, 6 in cell morphogenesis, 8 in cell development, 11 in cell differentiation, 6 in cell death, 13 in cell adhesion, 9 in extracellular matrix, and 50 in protein binding (overlapping occurring).
  • Gene annotation enrichment analyses of the clustered genes showed significant enrichment of annotations for the extracellular matrix (p < 0.0002), cell adhesion (p < 0.0001), and protein binding (p < 0.0004).
  • CONCLUSION: We conclude that a number of transcripts are deregulated in sporadic vestibular schwannomas, and that several of these have functional annotations implicated in tumorigenesis.
  • Specifically, genes involved in extracellular matrix function, cell adhesion, and protein binding seem to be of potential importance.
  • [MeSH-minor] Adult. Aged. Apoptosis / genetics. Cell Adhesion / genetics. Cell Cycle / genetics. Cell Differentiation / genetics. Extracellular Matrix / genetics. Female. Humans. Male. Middle Aged. Morphogenesis / genetics. Oligonucleotide Array Sequence Analysis. Prospective Studies. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Vestibular Nerve / metabolism

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  • (PMID = 19816230.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger
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23. Yamazaki M, Naganawa S, Kawai H, Nihashi T, Fukatsu H, Nakashima T: Increased signal intensity of the cochlea on pre- and post-contrast enhanced 3D-FLAIR in patients with vestibular schwannoma. Neuroradiology; 2009 Dec;51(12):855-63
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  • [Title] Increased signal intensity of the cochlea on pre- and post-contrast enhanced 3D-FLAIR in patients with vestibular schwannoma.
  • INTRODUCTION: In the vestibular schwannoma patients, the pathophysiologic mechanism of inner ear involvement is still unclear.
  • We investigated the status of the cochleae in patients with vestibular schwannoma by evaluating the signal intensity of cochlear fluid on pre- and post-contrast enhanced thin section three-dimensional fluid-attenuated inversion recovery (3D-FLAIR).
  • In 13 patients (26 cochleae) who underwent both gadolinium injection and the pure-tone audiometry, the post-contrast CM ratio correlated with hearing level (rho < 0.05).
  • CONCLUSION: The results of the present study suggest that alteration of cochlear fluid composition and increased permeability of the blood-labyrinthine barrier exist in the affected side in patients with vestibular schwannoma.

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  • (PMID = 19727694.001).
  • [ISSN] 1432-1920
  • [Journal-full-title] Neuroradiology
  • [ISO-abbreviation] Neuroradiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
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24. Gronau E, Arnholdt H, Harzmann R, Weckermann D: [Renal neurilemoma--a rare differential diagnosis of renal tumors]. Urologe A; 2005 Sep;44(9):1059-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Renal neurilemoma--a rare differential diagnosis of renal tumors].
  • [Transliterated title] Das Schwannom der Niere - Eine seltene Differenzialdiagnose renaler Raumforderungen.
  • Neurilemomas originate from the Schwann cells of nerve sheaths.
  • They can occur ubiquitously as benign or malign variants.
  • Renal neurilemomas are extremely rare.
  • Complete tumor resectioning is the only curative therapy.
  • Histological criteria of renal neurilemoma are: mesenchymal, spindle cell, capsulated tumor intensely positive to S-100 antiserum.
  • [MeSH-major] Kidney Neoplasms / pathology. Kidney Neoplasms / surgery. Neurilemmoma / pathology. Neurilemmoma / surgery

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  • (PMID = 15971046.001).
  • [ISSN] 0340-2592
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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25. Predescu D, Gheorghe M, Predoiu I, Iosif C, Constantin A, Chiru F, Cociu L, Constantinoiu S: [Gastrointestinal stromal tumor (GIST)--medical rarities?]. Chirurgia (Bucur); 2010 Jul-Aug;105(4):577-85
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  • [Title] [Gastrointestinal stromal tumor (GIST)--medical rarities?].
  • Considered as rare digestive cancers, tumors like schwannomas, neurofibromas, gastrointestinal leiomiomas are now reclassified as GIST based on immunohistochemistry studies.
  • Most with symptomatic disease: palpable tumor, abdominal pain, anemia, fatigue, superior digestive hemorrhage or occlusion.
  • The principle of surgery for GIST is RO resection of the tumor.
  • Tumor rupture or R1 resection of the primary tumor has a negative impact on disease free survival.


26. Hemminki K, Chen B: Are twins at risk of cancer: results from the Swedish family-cancer database. Twin Res Hum Genet; 2005 Oct;8(5):509-14
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  • Among other tumors, neurinomas and non-thyroid endocrine gland tumors were increased.
  • Melanoma and squamous cell skin cancer were decreased in male same-sex twins.

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  • (PMID = 16212840.001).
  • [ISSN] 1832-4274
  • [Journal-full-title] Twin research and human genetics : the official journal of the International Society for Twin Studies
  • [ISO-abbreviation] Twin Res Hum Genet
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Twin Study
  • [Publication-country] England
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27. Dagain A, Pouit B, Dutertre G, Dulou R: Role of cystoperitoneal shunt in the setup of cystic vestibular schwannomas drainage. Acta Neurochir (Wien); 2010 Aug;152(8):1441-2
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  • [Title] Role of cystoperitoneal shunt in the setup of cystic vestibular schwannomas drainage.

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  • [CommentOn] Acta Neurochir (Wien). 2010 Jan;152(1):177-80 [19693430.001]
  • (PMID = 20354735.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] Austria
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28. Nascimento AF, Fletcher CD: The controversial nosology of benign nerve sheath tumors: neurofilament protein staining demonstrates intratumoral axons in many sporadic schwannomas. Am J Surg Pathol; 2007 Sep;31(9):1363-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The controversial nosology of benign nerve sheath tumors: neurofilament protein staining demonstrates intratumoral axons in many sporadic schwannomas.
  • Schwannomas are benign peripheral nerve sheath tumors believed to be composed purely of cells with ultrastructural features of Schwann cells; these tumors are believed to develop eccentrically from the surface of nerves and not to contain axons, other than immediately beneath the capsule.
  • The usual presence of intratumoral axons in neurofibromas is said to allow easy distinction from schwannomas.
  • Eighty sporadic schwannomas (20 conventional, 20 cellular, 20 ancient, 10 gastric, and 10 plexiform) were retrieved from the authors' files.
  • NFP-positive axons were identified in 11 of 20 (55%) conventional schwannomas (2 rare, 4 focal, 3 multifocal, and 2 diffuse; 5 central, 4 peripheral, and 2 central and peripheral) and in 15 of 20 (75%) cellular schwannomas (3 rare, 6 focal, and 6 multifocal; 12 central, 1 peripheral, and 2 central and peripheral).
  • Of the 20 ancient schwannomas, 7 cases (35%) showed intratumoral axons, highlighted by NFP immunostaining (1 rare, 4 focal, 1 multifocal, and 1 diffuse; 4 peripheral, 2 central, and 1 central and peripheral).
  • Most cases of gastric schwannoma showed no evidence of intratumoral axons; 9 cases (90%) were negative for NFP and only 1 case (10%) was positive (focal and central).
  • Seven of 10 cases (70%) of plexiform schwannomas were negative for NFP, whereas only 3 cases (30%) showed positive axons (2 multifocal and 1 focal; 3 central).
  • The unexpected but quite frequent presence of intratumoral axons in schwannomas argues against conventional views of these lesions' pathogenesis as an eccentric encapsulated lesion and raises the possibility that a more diverse cell population, perhaps more closely resembling neurofibromas, may constitute these neoplasms.
  • Although NFP-positive axons were most often present in the conventional and cellular variants of schwannoma, their presence was also observed in a minority of ancient, gastric and plexiform schwannomas.
  • Differentiation between neurofibroma and schwannoma in cases with overlapping cytoarchitectural features should not be based solely on the presence or absence of NFP-positive axons within a given tumor.
  • [MeSH-major] Axons / chemistry. Neurilemmoma / diagnosis. Neurofibroma / diagnosis. Neurofilament Proteins / analysis. S100 Proteins / analysis. Schwann Cells / chemistry. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Cell Differentiation. Cell Proliferation. Diagnosis, Differential. Humans. Immunohistochemistry. Neoplasm Invasiveness. Predictive Value of Tests. Reproducibility of Results

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  • (PMID = 17721192.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neurofilament Proteins; 0 / S100 Proteins
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29. Martinez-Rodriguez M, Subramaniam MM, Calatayud AM, Ramos D, Navarro S, Llombart-Bosch A: Ossifying fibromyxoid tumor of soft parts mimicking a schwannoma with uncommon histology: a potential diagnostic pitfall. J Cutan Pathol; 2009 Jan;36(1):71-3
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  • [Title] Ossifying fibromyxoid tumor of soft parts mimicking a schwannoma with uncommon histology: a potential diagnostic pitfall.
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Neurilemmoma / pathology

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  • (PMID = 19125736.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Denmark
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30. Mourmouras V, Taddeucci P, Ambrosio MR, Miracco C: Neuroblastoma-like neurilemoma: an additional case. J Dermatol; 2008 Aug;35(8):548-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neuroblastoma-like neurilemoma: an additional case.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Neurilemmoma / diagnosis
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Female. Humans. S100 Proteins / analysis

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  • (PMID = 18789078.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins
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31. Huang DQ, Li WR, Ou XY, Chen M: [A case of neurilemoma of larynx]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2005 Aug;40(8):600
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  • [Title] [A case of neurilemoma of larynx].
  • [MeSH-major] Laryngeal Neoplasms / pathology. Neurilemmoma / pathology

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  • (PMID = 16270878.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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32. Kienemund J, Liegl B, Siebert F, Jagoditsch M, Spuller E, Langner C: Microcystic reticular schwannoma of the colon. Endoscopy; 2010;42 Suppl 2:E247
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  • [Title] Microcystic reticular schwannoma of the colon.
  • [MeSH-major] Colonic Polyps / surgery. Neurilemmoma / pathology. Sigmoid Neoplasms / surgery

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  • (PMID = 20931464.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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33. Dadkhah F, Salimi M, Kaviani A: Benign retroperitoneal schwannoma mimicking adrenal mass. Urol J; 2005;2(1):49-51
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  • [Title] Benign retroperitoneal schwannoma mimicking adrenal mass.

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  • (PMID = 17629897.001).
  • [ISSN] 1735-1308
  • [Journal-full-title] Urology journal
  • [ISO-abbreviation] Urol J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
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34. Mizuno T, Usami N, Taniguchi T, Kawaguchi K, Okagawa T, Yokoi K: Schwannoma of the sternum. Ann Thorac Surg; 2010 Apr;89(4):1280-1
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  • [Title] Schwannoma of the sternum.
  • A primary sternal tumor is rare, and it is difficult to make an accurate diagnosis.
  • We herein report a case of intraosseous schwannoma of the sternum, which was associated with various difficulties in regard to making an accurate preoperative diagnosis.
  • A 38-year-old woman underwent a surgical resection for a sternal tumor.
  • The pathologic findings of the resected specimen revealed schwannoma, Antoni type A.
  • [MeSH-major] Bone Neoplasms. Neurilemmoma. Sternum

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  • [Copyright] Copyright (c) 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20338357.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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35. Lu CL, Chen MH, Chao TK: Dumbbell-shaped cervical spinal neurilemmoma presenting as neck mass. J Laryngol Otol; 2005 Dec;119(12):1018-20
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  • [Title] Dumbbell-shaped cervical spinal neurilemmoma presenting as neck mass.
  • Cervical neurilemmoma may originate from any nerve sheath tissue in the neck including the vagus nerve, glossopharyngeal nerve, brachial plexus, sympathetic trunk and cervical spine.
  • We report an unusual case of a dumbbell-shaped neurilemmoma arising from the cervical spinal roots in a patient who complained of having had a neck mass for several months.
  • Computed tomographic scan and magnetic resonance imaging revealed a dumbbell-shaped tumour extending from the C4 spinal level through the intervertebral foramen into the right parapharyngeal space.
  • Five months later, the patient received laminectomy and a complete tumour excision.
  • This two-staged operation could offer an alternative surgical approach yielding ideal therapeutic results in such a rare disease.
  • [MeSH-major] Neurilemmoma / diagnosis. Spinal Cord Compression / etiology. Spinal Cord Neoplasms / diagnosis

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  • (PMID = 16354375.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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36. Ferber-Viart C, Dubreuil C, Vidal PP: Effects of acetyl-DL-leucine in vestibular patients: a clinical study following neurotomy and labyrinthectomy. Audiol Neurootol; 2009;14(1):17-25
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  • To test this hypothesis, we investigated the efficacy of acetyl-DL-leucine during the acute stage following neurotomy or labyrinthectomy in patients undergoing surgery for unilateral vestibular acoustic neurinoma, or suffering from unilateral and intractable Ménière's disease.
  • For patients who had achieved a close to perfect compensation before surgery, acetyl-DL-leucine had minor or no effect after surgery.
  • For patients who displayed residual vestibular function before surgery, acetyl-DL-leucine eased the static vestibular syndromes, which followed neurotomy.
  • [MeSH-major] Leucine / analogs & derivatives. Meniere Disease / drug therapy. Meniere Disease / surgery. Neuroma, Acoustic / drug therapy. Neuroma, Acoustic / surgery


37. Sengöz A, Taşdemiroğlu E, Togay H: Is clear cell sarcoma a malignant form of psammomatous melanotic schwannoma? Case report. Neurosurg Focus; 2006;21(6):E11
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  • [Title] Is clear cell sarcoma a malignant form of psammomatous melanotic schwannoma? Case report.
  • The authors present a case of clear cell sarcoma (CCS) in which the tumor originated in the S-1 nerve root and had been previously diagnosed as psammomatous melanotic schwannoma (PMS).
  • The border of the resection was extended 1 cm distal to the tumor margin.
  • Despite total resection, the patient returned with disseminated disease at the 18-month follow-up visit.
  • [MeSH-major] Neurilemmoma / classification. Peripheral Nervous System Neoplasms / classification. Sarcoma, Clear Cell / classification. Spinal Nerve Roots / pathology
  • [MeSH-minor] Adolescent. Adult. Antigens, Neoplasm. Biomarkers, Tumor / analysis. Breast Neoplasms. Diagnosis, Differential. Diagnostic Errors. Female. Fibroadenoma. Humans. Keratins / analysis. Male. Melanins / analysis. Melanoma-Specific Antigens. Neoplasm Invasiveness. Neoplasm Proteins / analysis. Neoplasm Recurrence, Local. Neoplasms, Multiple Primary. Neoplastic Syndromes, Hereditary / diagnosis. Neoplastic Syndromes, Hereditary / genetics. Nerve Sheath Neoplasms / pathology. Pigmentation Disorders / diagnosis. Pigmentation Disorders / genetics. Prognosis. S100 Proteins / analysis. Sacrococcygeal Region. Syndrome. Vimentin / analysis

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  • (PMID = 17341045.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Melanins; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins
  • [Number-of-references] 17
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38. Melroy CT, Senior BA: Benign sinonasal neoplasms: a focus on inverting papilloma. Otolaryngol Clin North Am; 2006 Jun;39(3):601-17, x
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  • [Title] Benign sinonasal neoplasms: a focus on inverting papilloma.
  • Benign sinonasal neoplasms are a pathologic and clinically varied group of tumors.
  • The treatment algorithm for this tumor has undergone a complex evolution that continues today.
  • [MeSH-minor] Endoscopy. Hamartoma / diagnosis. Hamartoma / pathology. Humans. Magnetic Resonance Imaging. Meningioma / diagnosis. Meningioma / pathology. Neurilemmoma / diagnosis. Neurilemmoma / pathology. Neurofibroma / diagnosis. Neurofibroma / pathology. Tomography, X-Ray Computed

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  • (PMID = 16757234.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 60
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39. Aghi M, Barker FG 2nd: Benign adult brain tumors: an evidence-based medicine review. Prog Neurol Surg; 2006;19:80-96
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  • [Title] Benign adult brain tumors: an evidence-based medicine review.
  • BACKGROUND: Benign adult brain tumors can be managed conservatively or using surgery, radiation, or medicines.
  • While randomized comparisons assessing tumor recurrence, quality of life, or survival are the ideal means of comparing treatments, it can be difficult to recruit patients to such trials and lengthy follow-up periods are needed because of the slowly progressive natural history of these tumors.
  • METHODS: Review of the literature on benign adult brain tumors using evidence-based standards and focusing on meningiomas, pituitary adenomas, and vestibular schwannomas, which together represent the majority of WHO grade 1 adult brain tumors.
  • RESULTS: Nearly all studies of benign adult brain tumors were of relatively poor quality (level 3 or poorer).
  • These studies enable grade C recommendations.
  • Vestibular schwannomas can be conservatively managed, but there are no reliable predictors of growth, so serial imaging is important.
  • Radiosurgery has proven to be a reliable alternative to surgery for small to medium-sized vestibular schwannomas, but followup has been relatively short in most studies to date.
  • CONCLUSIONS: While randomized clinical trials comparing conservative management, surgery, radiation, and medical management of benign adult benign tumors are unlikely to occur, there is some level 3 evidence that can assist in their treatment.

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  • (PMID = 17033148.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 58
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40. Hung SF, Chung SD, Lai MK, Chueh SC, Yu HJ: Renal Schwannoma: case report and literature review. Urology; 2008 Sep;72(3):716.e3-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Renal Schwannoma: case report and literature review.
  • Schwannomas are tumors arising from the nerve sheath.
  • Renal schwannomas are extremely rare and have nonspecific symptoms and limited radiologic features, and are often diagnosed histologically after surgical excision.
  • We report a case of a left renal schwannoma which, after evaluation by imaging studies, was assumed to be a renal cell carcinoma arising from the left kidney.
  • [MeSH-major] Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / therapy. Kidney Neoplasms / diagnosis. Kidney Neoplasms / therapy. Neurilemmoma / diagnosis. Neurilemmoma / therapy

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  • (PMID = 18314178.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Schupp DJ, Mukherjee D, Sharma GK: Schwannoma of the vagus nerve masquerading as a carotid body tumor. Vascular; 2009 Jul-Aug;17(4):222-5
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  • [Title] Schwannoma of the vagus nerve masquerading as a carotid body tumor.
  • He was found to have a schwannoma of the vagus nerve with compression of the right hypoglossal nerve.
  • A discussion of this case is followed by a review of the literature surrounding this rare disease and this unique presentation.
  • [MeSH-major] Carotid Body Tumor / diagnosis. Cranial Nerve Neoplasms / diagnosis. Neurilemmoma / diagnosis. Vagus Nerve Diseases / diagnosis

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  • (PMID = 19698304.001).
  • [ISSN] 1708-5381
  • [Journal-full-title] Vascular
  • [ISO-abbreviation] Vascular
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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42. Lüdemann WO, Stieglitz LH, Gerganov V, Samii A, Samii M: Fat implant is superior to muscle implant in vestibular schwannoma surgery for the prevention of cerebrospinal fluid fistulae. Neurosurgery; 2008 Jul;63(1 Suppl 1):ONS38-42; discussion 42-3
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  • [Title] Fat implant is superior to muscle implant in vestibular schwannoma surgery for the prevention of cerebrospinal fluid fistulae.
  • OBJECTIVE: Meticulous sealing of opened air cells in the petrous bone is necessary for the prevention of cerebrospinal fluid (CSF) fistulae after vestibular schwannoma surgery.
  • Analysis was performed regarding the incidence of postoperative CSF fistulae and correlation with the patient's sex and tumor grade.
  • There was an inverse correlation with tumor grade.
  • CONCLUSION: Fat implantation is superior to muscle implantation for the prevention of CSF leakage after vestibular schwannoma surgery and should, therefore, be used for the sealing of opened air cells in cranial base surgery.

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  • (PMID = 18728602.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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43. Saberi H, Khashayar P: Olfactory groove schwannoma masquerading as an orbital mass. Neurosciences (Riyadh); 2008 Jan;13(1):73-6
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  • [Title] Olfactory groove schwannoma masquerading as an orbital mass.
  • Olfactory groove schwannoma is a very rare tumor breaking through the skull base and orbit.
  • The tumor may also extend to the subfrontal region intradurally.
  • A case of olfactory groove schwannoma in a 35-year-old female, originating from the left olfactory groove with left proptosis, diplopia, supra-orbital mass, and gross intracranial extension is reported.
  • Histological examination and immuno-histochemical evaluation for S-100 protein, showed the tumor as a schwannoma.

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  • (PMID = 21063292.001).
  • [ISSN] 1319-6138
  • [Journal-full-title] Neurosciences (Riyadh, Saudi Arabia)
  • [ISO-abbreviation] Neurosciences (Riyadh)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
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44. Machner B, Gottschalk S, Sander T, Helmchen C, Rambold H: Intralabyrinthine schwannoma affecting the low but not high frequency function of the vestibulo-ocular reflex: implications for the clinical diagnosis of chronic peripheral vestibular deficits. J Neurol Neurosurg Psychiatry; 2007 Jul;78(7):772-4
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  • [Title] Intralabyrinthine schwannoma affecting the low but not high frequency function of the vestibulo-ocular reflex: implications for the clinical diagnosis of chronic peripheral vestibular deficits.
  • [MeSH-minor] Chronic Disease. Humans. Middle Aged. Neurilemmoma

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  • (PMID = 17575027.001).
  • [ISSN] 1468-330X
  • [Journal-full-title] Journal of neurology, neurosurgery, and psychiatry
  • [ISO-abbreviation] J. Neurol. Neurosurg. Psychiatry
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45. Muzzafar S, Ketonen L, Weinberg JS, Schellingerhout D: Imaging and clinical features of an intra-axial brain stem schwannoma. AJNR Am J Neuroradiol; 2010 Mar;31(3):567-9
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  • [Title] Imaging and clinical features of an intra-axial brain stem schwannoma.
  • A 68-year-old man presented with a highly symptomatic brain stem tumor originally thought to be a brain stem glioma.
  • Intraoperative MR imaging guidance was used to resect the tumor, and real-time evoked potentials improved during surgery.
  • Pathology findings unexpectedly indicated that the tumor was an intra-axial brain stem schwannoma, a condition reported, to our knowledge, only 6 times previously in the literature.
  • [MeSH-major] Brain Stem Neoplasms / pathology. Magnetic Resonance Imaging. Neurilemmoma / pathology

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  • (PMID = 19833800.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Plotkin SR, Halpin C, Blakeley JO, Slattery WH 3rd, Welling DB, Chang SM, Loeffler JS, Harris GJ, Sorensen AG, McKenna MJ, Barker FG 2nd: Suggested response criteria for phase II antitumor drug studies for neurofibromatosis type 2 related vestibular schwannoma. J Neurooncol; 2009 May;93(1):61-77
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  • [Title] Suggested response criteria for phase II antitumor drug studies for neurofibromatosis type 2 related vestibular schwannoma.
  • Neurofibromatosis type 2 (NF2) is a tumor suppressor gene syndrome characterized by multiple schwannomas, especially vestibular schwannomas (VS), and meningiomas.
  • We also identify research goals in NF2 to facilitate future trial conduct, such as identifying the expectations for time to tumor progression and time to measurable hearing loss in untreated NF2-related VS, and the relation of both endpoints to patient prognostic factors (such as age, baseline tumor volume, and measures of disease severity).
  • These data would facilitate future use of endpoints based on stability of tumor size and hearing, which might be more appropriate for testing certain drugs.

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  • (PMID = 19430883.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA006973
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 154
  • [Other-IDs] NLM/ NIHMS573252; NLM/ PMC4036446
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47. Gerszten PC, Burton SA, Ozhasoglu C, McCue KJ, Quinn AE: Radiosurgery for benign intradural spinal tumors. Neurosurgery; 2008 Apr;62(4):887-95; discussion 895-6
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  • [Title] Radiosurgery for benign intradural spinal tumors.
  • OBJECTIVE: The role of stereotactic radiosurgery for the treatment of intracranial benign tumors is well established.
  • There is less experience and more controversy regarding its use for benign tumors of the spine.
  • This study evaluated the clinical efficacy of radiosurgery as part of the treatment paradigm of selected benign tumors of the spine.
  • METHODS: Seventy-three benign intradural extramedullary spinal tumors were treated with a radiosurgery technique and prospectively evaluated.
  • Tumor histology included neurofibroma (25 cases), schwannoma (35 cases), and meningioma (13 cases).
  • Tumor volume ranged from 0.3 to 93.4 cm (mean, 10.5 cm; median, 4.11 cm).
  • Radiosurgery was used for the treatment of postsurgical radiographic progression in 18 cases; it was used as the primary treatment modality in 14 cases; it was used for treatment of radiographic tumor progression in nine cases; and it was used for the treatment of postsurgical residual tumor in two cases.
  • Long-term radiographic tumor control was demonstrated in all cases.
  • CONCLUSION: Single fraction radiosurgery was found to be clinically effective for the treatment of benign extramedullary spinal neoplasms.
  • Although surgical extirpation remains the primary treatment option for most benign spinal tumors, radiosurgery was demonstrated to have short-term clinical benefits for the treatment of such lesions.

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  • (PMID = 18496194.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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48. Sevimli S, Erkut B, Becit N, Aksakal E, Polat P: Primary benign schwannoma of the left ventricle coursing under the left anterior descending artery. Echocardiography; 2007 Nov;24(10):1093-5
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  • [Title] Primary benign schwannoma of the left ventricle coursing under the left anterior descending artery.
  • Histological examination revealed a benign primary schwannoma of the heart.
  • To our knowledge, this is the first reported case of benign schwannoma of left ventricle in an adult.
  • [MeSH-major] Echocardiography, Doppler / methods. Heart Neoplasms / diagnosis. Heart Ventricles. Neurilemmoma / diagnosis

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  • (PMID = 18001365.001).
  • [ISSN] 0742-2822
  • [Journal-full-title] Echocardiography (Mount Kisco, N.Y.)
  • [ISO-abbreviation] Echocardiography
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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49. Gouveris HT, Mann WJ: Quality of life in sporadic vestibular schwannoma: a review. ORL J Otorhinolaryngol Relat Spec; 2010;72(2):69-74
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  • [Title] Quality of life in sporadic vestibular schwannoma: a review.
  • Methods and questionnaires currently used for QoL assessment in vestibular schwannoma (VS) patients, studies evaluating QoL before and after treatment, studies on patients managed conservatively and studies evaluating facial-nerve-function-related QoL in VS patients are reviewed.

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20431315.001).
  • [ISSN] 1423-0275
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 42
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50. Asano K, Takeda T, Nakano T, Ohkuma H: Correlation of MIB-1 staining index and (201)Tl-SPECT retention index in preoperative evaluation of malignancy of brain tumors. Brain Tumor Pathol; 2010 Apr;27(1):1-6
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  • The subjects of this study were 47 patients who underwent tumor removal surgery at our hospital in 2006 and 2007.
  • The tumors consisted of 16 intraaxial tumors (all gliomas: 9 glioblastomas, 2 anaplastic astrocytomas, 2 anaplastic oligoastrocytomas, 1 oligodendroglioma, and 2 ependymomas), 8 other malignant brain tumors, and 23 extraaxial tumors (10 meningiomas, 7 pituitary adenomas, and 6 schwannomas).
  • RI values may also be useful for evaluating apparently benign extraaxial tumors for possible malignancy.
  • [MeSH-major] Biomarkers, Tumor / analysis. Brain Neoplasms / diagnosis. Brain Neoplasms / pathology. Ki-67 Antigen / analysis. Preoperative Period. Staining and Labeling. Tomography, Emission-Computed, Single-Photon

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  • (PMID = 20425041.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Radiopharmaceuticals; 0 / Thallium Radioisotopes
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51. Barrenechea IJ, Fukumoto R, Lesser JB, Ewing DR, Connery CP, Perin NI: Endoscopic resection of thoracic paravertebral and dumbbell tumors. Neurosurgery; 2006 Dec;59(6):1195-201; discussion 1201-2
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  • Final pathology included four neurofibromas, eight schwannomas, and one unclassified granular cell tumor.
  • Three patients required a hemilaminectomy for resection of the intraspinal dumbbell component of the tumor during the same operation.

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  • (PMID = 17277682.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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52. Hatori M, Hosaka M, Watanabe M, Moriya T, Sasano H, Kokubun S: Osteosarcoma in a patient with neurofibromatosis type 1: a case report and review of the literature. Tohoku J Exp Med; 2006 Apr;208(4):343-8
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  • Neurofibromatosis type 1 (NF1) or von Recklinghausen's disease is a genetic disease generally characterized by café-au-lait spots and neurofibromas.
  • Malignant tumors of the nervous system, such as malignant schwannomas, gliomas, or astrocytomas, have been well known to coexist with neurofibromatosis.
  • We report an unusual case of a 29-year-old NF1 female suffering from malignant peripheral nerve sheath tumor (MPNST) that eventually developed osteosarcoma in the proximal femur.
  • Osteosarcoma is the most common high-grade malignant bone tumor in which the neoplastic cells produce osteoid.
  • Magnetic resonance imaging revealed extraskeletal growth of the tumor.
  • The removed tumor was composed of highly anaplastic cells.
  • Lace-like irregular osteoid formation was observed among the tumor cells.
  • The tumor was diagnosed as osteoblastic type osteosarcoma.
  • The correlation between the histogenesis of osteosarcoma and the genetic abnormality in NF1 patients has not been elucidated, but the finding of osteosarcomatous transformation in this case suggests the divergent cellular differentiation to mesenchymal malignant tumors of neuroectodermal tissue in NF1 patients.
  • [MeSH-minor] Adult. Cell Transformation, Neoplastic. Combined Modality Therapy. Fatal Outcome. Female. Femur / pathology. Femur / radiography. Humans. Magnetic Resonance Imaging. Nerve Sheath Neoplasms / pathology. Nerve Sheath Neoplasms / therapy


53. Shetty C, Avinash KR, Auluck A: Schwannoma of vagus nerve masquerading as a parotid tumour. Dentomaxillofac Radiol; 2006 Sep;35(5):376-9
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  • [Title] Schwannoma of vagus nerve masquerading as a parotid tumour.
  • A post-auricular swelling is the most common presentation of a parotid tumour, the majority of which are benign neoplasms like pleomorphic adenoma.
  • This case report discusses a post-styloid parapharyngeal space tumour presenting as a post-auricular mass which, on initial clinical and cytological examination, was diagnosed as pleomorphic adenoma.
  • A cross-sectional radiological examination revealed the true location of the mass, which was histopathologically confirmed to be a vagal schwannoma.
  • [MeSH-major] Cranial Nerve Neoplasms / radiography. Neurilemmoma / radiography. Vagus Nerve Diseases / radiography

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  • (PMID = 16940487.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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54. Bello MJ, Martinez-Glez V, Franco-Hernandez C, Pefla-Granero C, de Campos JM, Isla A, Lassaletta L, Vaquero J, Rey JA: DNA methylation pattern in 16 tumor-related genes in schwannomas. Cancer Genet Cytogenet; 2007 Jan 1;172(1):84-6
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  • [Title] DNA methylation pattern in 16 tumor-related genes in schwannomas.
  • [MeSH-major] DNA Methylation. Genes, Neoplasm. Nerve Sheath Neoplasms / genetics. Neurilemmoma / genetics

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  • (PMID = 17175387.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] United States
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55. Chiang ER, Chang MC, Chen TH: Giant retroperitoneal schwannoma from the fifth lumbar nerve root with vertebral body osteolysis: a case report and literature review. Arch Orthop Trauma Surg; 2009 Apr;129(4):495-9
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  • [Title] Giant retroperitoneal schwannoma from the fifth lumbar nerve root with vertebral body osteolysis: a case report and literature review.
  • STUDY DESIGN: To report a rare case of retroperitoneal schwannoma from lumbar nerve root with difficult surgery and potential vascular complication.
  • OBJECTIVE: We report a rare case of giant schwannoma which arises from fifth lumbar root with L5 vertebral body destruction.
  • Retroperitoneal schwannomas are rare, and those with bony involvement are even rarer and may be mimicking malignant tumors.
  • METHODS: Retroperitoneal removal of the tumor with partial killing of right L5 nerve root and allograft of L5 vertebral body defect were performed.
  • Incidental injury of common iliac vein was encountered due to adhesion of the vein to tumor capsule.
  • CONCLUSIONS: Retroperitoneal schwannomas are rare, and they can become very large when diagnosed.
  • [MeSH-major] Neurilemmoma / complications. Neurilemmoma / surgery. Retroperitoneal Neoplasms / complications. Retroperitoneal Neoplasms / surgery. Spinal Neoplasms / surgery

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  • (PMID = 18438680.001).
  • [ISSN] 1434-3916
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 30
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56. Huang SQ, Liang BL, Yuan JP, Zhong JL: [MRI performance and diagnosis of schwannomas from cranial nerves in posterior cranial fossae]. Ai Zheng; 2006 Sep;25(9):1178-82
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  • [Title] [MRI performance and diagnosis of schwannomas from cranial nerves in posterior cranial fossae].
  • BACKGROUND & OBJECTIVE: Cranial nerve schwannomas originate frequently in posterior cranial fossae and have various and complex MRI performances, some of which are still not well known.
  • This study was to explore MRI performances and features of schwannomas from cranial nerves in posterior cranial fossae.
  • METHODS: The MRI performances of 75 cases of schwannoma from cranial nerves in posterior cranial fossae, including trigeminal (n=9), facial (n=1), acoustic (n=53), 9th-11th (n=9) and hypoglossal (n=3) schwannomas, confirmed by surgical and pathologic findings, were analyzed retrospectively.
  • RESULTS: Most of schwannomas in posterior cranial fossae were solid-cystic lesions when their sizes were larger than 1.5 cm in diameter.
  • On T1WI, the solid part of tumor appeared iso- or slightly hypointense, while cystic part was hypointense.
  • Some typical signs were very useful to infer tumor origin, such as, dumbbell-shaped trigeminal schwannoma extended across the middle and posterior cranial fossa, enlargement of internal auditory canal, widened jugular foramen and hypoglossal foramen caused by acoustic schwannoma, the 9th-11th shcwannoma, and hypoglossal schwannoma, respectively.
  • The correct ratio for qualitative diagnosis of schwannoma was 92% using MRI, but the incorrect ratio for identifying the nerve of tumor origin was 8.7%.
  • CONCLUSION: MRI is a good method in qualitative diagnosis of schwannoma and identifying cranial nerves of tumor origin in posterior cranial fossae.
  • [MeSH-major] Cranial Nerve Neoplasms / diagnosis. Magnetic Resonance Imaging. Neurilemmoma / diagnosis. Neuroma, Acoustic / diagnosis. Trigeminal Nerve Diseases / diagnosis

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  • (PMID = 16965666.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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57. Inoue T, Satou M, Morii H, Matsuda T: [Schwannoma of the penis: a case report]. Hinyokika Kiyo; 2008 Aug;54(8):569-72
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  • [Title] [Schwannoma of the penis: a case report].
  • We suspected a benign tumor of the penis and removed it.
  • Histological examination revealed a benign schwannoma composed of Antoni A and Antoni B areas.
  • [MeSH-major] Neurilemmoma / diagnosis. Neurilemmoma / surgery. Penile Neoplasms / diagnosis. Penile Neoplasms / surgery

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  • (PMID = 18788450.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 17
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58. Agarwal K, Agarwal C, Agarwal M, Harbhajanka A: Plexiform schwannoma of scalp: a case report with brief review of literature. Indian J Pathol Microbiol; 2007 Oct;50(4):797-9
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  • [Title] Plexiform schwannoma of scalp: a case report with brief review of literature.
  • Plexiform schwannoma is a morphologically distinct and rare variant of schwannoma.
  • It is a benign tumor and malignant transformation has not been reported.
  • We are presenting a case of plexiform schwannoma occurring on scalp and measuring 8cm in size because of its rarity and unusual size.
  • [MeSH-major] Neurilemmoma / diagnosis. Neurilemmoma / pathology. Scalp / pathology

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  • The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for plexiform schwannoma .
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  • (PMID = 18306559.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 15
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59. Jaiswal A, Shetty AP, Rajasekaran S: Giant cystic intradural schwannoma in the lumbosacral region: a case report. J Orthop Surg (Hong Kong); 2008 Apr;16(1):102-6
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  • [Title] Giant cystic intradural schwannoma in the lumbosacral region: a case report.
  • We report a case of a giant cystic intradural schwannoma of the lumbosacral region in a 30- year-old man who presented with a 2-year history of non-specific lower back pain.
  • The tumour was completely excised.
  • Histological investigation confirmed the diagnosis of cystic schwannoma with alternating hypercellular (Antoni A) and hypocellular (Antoni B) areas in a fibrillar background.
  • [MeSH-major] Neurilemmoma. Spinal Cord Neoplasms

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  • (PMID = 18453671.001).
  • [ISSN] 1022-5536
  • [Journal-full-title] Journal of orthopaedic surgery (Hong Kong)
  • [ISO-abbreviation] J Orthop Surg (Hong Kong)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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60. Kandziora F, Pingel A: Posterior resection of a cervical spine neurinoma. Eur Spine J; 2010 Jun;19(6):1044-5
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  • [Title] Posterior resection of a cervical spine neurinoma.
  • [MeSH-major] Cervical Vertebrae / surgery. Neurilemmoma / surgery. Neurosurgical Procedures / methods. Spinal Neoplasms / surgery

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  • [Cites] Surg Neurol. 2004 Jan;61(1):34-43; discussion 44 [14706374.001]
  • [Cites] Acta Neurochir (Wien). 1993;122(1-2):91-6 [8333314.001]
  • (PMID = 20514497.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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61. Bouccara D, Kalamarides M, Bozorg Grayeli A, Ambert-Dahan E, Rey A, Sterkers O: [Auditory brainstem implant: indications and results]. Ann Otolaryngol Chir Cervicofac; 2007 Jul;124(3):148-54
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  • Emergent indications are bilateral total ossified cochlea, vestibular schwannoma with controlateral lesions, cochlear nerve aplasia or inner ear's malformations.
  • RESULTS: In NF2 patients, best results are obtained in cases of smaller vestibular schwannoma and none, or short term, auditory deprivation.
  • Negative prognostic factors are duration of total hearing loss (>10 years), tumor size (>30 mm), difficulties in electrode array placement, complications during post-operative course and number of active electrodes (<10).
  • CONCLUSION: These results show a clear benefit of ABI in NF2 patients, with or without previous tumor removal, in case of small tumor with a short duration of hearing loss.

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  • (PMID = 17320034.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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62. Donzelli R, Maiuri F, Peca C, Cavallo LM, Motta G, de Divitiis E: Microsurgical repair of the facial nerve. Zentralbl Neurochir; 2005 May;66(2):63-9
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  • OBJECTIVE: To report a series of 18 patients who underwent microsurgical repair of the facial nerve using different techniques and to discuss the indications and results of facial reinnervation procedures.
  • 'These included classic hypoglossal-facial anastomosis in 13 cases, one-stage hemihypoglossal-intratemporal facial nerve anastomosis and translabyrinthine removal of residual intra-canalar acoustic schwannoma in 3, hemihypoglossal-facial nerve anastomosis in one, and neurotization of facial muscles through a nerve graft in one.
  • RESULTS: The facial muscle function improved in all patients, up to grade III in 7 cases (39 %), grade IV in 9 (50 %) and grade V in 2 (11 %).
  • The outcome was better in younger patients (less than 40 years of age) and in those with a lesser grade of preoperative facial impairment.
  • The use of the intratemporal facial nerve is indicated when removal of an intra-canalar residual schwannoma must also be performed.

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  • (PMID = 15846533.001).
  • [ISSN] 0044-4251
  • [Journal-full-title] Zentralblatt für Neurochirurgie
  • [ISO-abbreviation] Zentralbl. Neurochir.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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63. Bertagna F, Bosio G, Biasiotto G, Fisogni S, Bercich L, Giubbini R: Malignant transformation to schwannoma in a patient affected by type 1 neurofibromatosis as demonstrated by F-18-FDG-PET/CT. Nucl Med Rev Cent East Eur; 2010;13(1):15-7
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  • [Title] Malignant transformation to schwannoma in a patient affected by type 1 neurofibromatosis as demonstrated by F-18-FDG-PET/CT.
  • Neurofibromatosis type I (NF1) is an autosomal dominant multisystem disorder.
  • Patients with NF1 are at increased risk for developing both benign and malignant tumours.
  • We report the case of a patient with histologically documented NF1, who underwent F18-FDG-PET/CT for staging purposes.
  • The surgical biopsy of the largest popliteal lesion with higher uptake at F18-FDG-PET/CT documented the presence of a malignant schwannoma at histological examination.
  • In conclusion, F18-FDG-PET/CT was probably able to help the discrimination between benign lesions related to known NF1 and the malignant transformed ones, and to assist clinical decision making.
  • [MeSH-major] Cell Transformation, Neoplastic. Fluorodeoxyglucose F18. Neurilemmoma / diagnosis. Neurilemmoma / pathology. Neurofibromatosis 1 / complications. Positron-Emission Tomography. Tomography, X-Ray Computed


64. Cheshire WP, Odell JA, Woodward TA, Wharen RE Jr: Cervical sympathetic neuralgia arising from a schwannoma. Headache; 2007 Mar;47(3):444-6
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  • [Title] Cervical sympathetic neuralgia arising from a schwannoma.
  • We describe an unusual case of neuropathic pain of the left face and shoulder accompanied by ipsilateral hyperhidrosis caused by a schwannoma of the cervical sympathetic chain.
  • The pain was refractory to analgesic and antimigraine medications but resolved following surgical resection of the T2 schwannoma.
  • [MeSH-major] Autonomic Nervous System Diseases / complications. Face. Nervous System Neoplasms / complications. Neuralgia / etiology. Neurilemmoma / complications. Shoulder


65. Lang-Lazdunski L, Pilling J: Videothoracoscopic excision of mediastinal tumors and cysts using the harmonic scalpel. Thorac Cardiovasc Surg; 2008 Aug;56(5):278-82
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  • METHODS: We have prospectively studied 19 cases presenting with a mediastinal tumor or cyst operated on consecutively since January 2003.
  • The maximum tumor diameter was 38 +/- 14 mm and the maximum cyst dimension was 55 +/- 20 mm.
  • Histopathology revealed 1 esophageal leiomyosarcoma, 1 Langerhans cell histiocytosis X, 1 hamartoma, 5 schwannomas, 1 neurofibroma, 1 malignant peripheral nerve sheath tumor, 1 reactive lymphadenopathy, 1 tuberculous lymphadenopathy, 1 cystic hygroma, 2 bronchogenic cysts, 2 foregut cysts, 1 thymic cyst, and 1 pleuropericardial cyst.
  • There has been no recurrence of tumor or cyst on follow-up.

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  • (PMID = 18615374.001).
  • [ISSN] 0171-6425
  • [Journal-full-title] The Thoracic and cardiovascular surgeon
  • [ISO-abbreviation] Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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66. Tringali S, Marzin A, Zaouche S, Céruse P, Dubreuil C: [Meningiomas of the posterior petrous bone: diagnostic and therapeutic aspects]. J Otolaryngol Head Neck Surg; 2008 Feb;37(1):98-104
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  • OBJECTIVE: To compare the clinical and paraclinical picture and the postoperative results of meningiomas of the posterior petrous bone and to compare them with those of vestibular schwannomas (VSs) operated on by the same surgical team.
  • CONCLUSION: Meningiomas of the posterior temporal bone may present clinically and radiologically like a VS, especially for intracanalar tumour and stage IV tumours.

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  • (PMID = 18479635.001).
  • [ISSN] 1916-0216
  • [Journal-full-title] Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
  • [ISO-abbreviation] J Otolaryngol Head Neck Surg
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Canada
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67. Talwalkar SC, Cutler L, Stilwell JH: Multiple plexiform schwannoma of the hand and forearm: a long-term follow-up. J Hand Surg Br; 2005 Aug;30(4):358-60
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  • [Title] Multiple plexiform schwannoma of the hand and forearm: a long-term follow-up.
  • We present a case report to illustrate the differential diagnosis and management of a multiple plexiform schwannoma involving the main nerve trunks of the upper limb in a 4 year-old boy.
  • The tumour was diagnosed by MRI scan and histological examination.
  • [MeSH-major] Forearm. Hand. Median Nerve. Neurilemmoma / surgery. Ulnar Nerve

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  • (PMID = 15950336.001).
  • [ISSN] 0266-7681
  • [Journal-full-title] Journal of hand surgery (Edinburgh, Scotland)
  • [ISO-abbreviation] J Hand Surg Br
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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68. Dohi O, Hatori M, Ichinohasama R, Hosaka M, Hashimoto S, Kokubun S: Diffuse large B-cell lymphoma arising in a patient with neurofibromatosis type I and in a patient with neurofibromatosis type II. Tohoku J Exp Med; 2006 Feb;208(2):169-76
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  • [Title] Diffuse large B-cell lymphoma arising in a patient with neurofibromatosis type I and in a patient with neurofibromatosis type II.
  • We experienced two unusual cases of diffuse large B-cell lymphoma (DLBCL), which occurred in a patient with neurofibromatosis type I and a patient with neurofibromatosis type II.
  • B-cell lymphoma is one of the most common phenotypic subgroups of malignant lymphoma.
  • Neurofibromatosis II typically consists of bilateral schwannomas of the acoustic nerve.
  • The patient with neurofibromatosis I was a 50-year-old Japanese woman, clinically manifesting von Recklinghausen's disease since infancy, who noticed an egg-sized tumor in her shoulder.
  • The patient with neurofibromatosis II was a 39-year-old Japanese man who noticed multiple soft tissue tumors in his neck, buttock, and elbow.
  • Flow cytometry revealed large-scale cells to be tumor cells, and they were positive for CD19, CD20, and CD22.
  • [MeSH-major] Lymphoma, B-Cell / complications. Lymphoma, Large B-Cell, Diffuse / complications. Neurofibromatosis 1 / complications. Neurofibromatosis 2 / complications. Skin Neoplasms / complications. Soft Tissue Neoplasms / complications
  • [MeSH-minor] Adult. Biomarkers, Tumor. Female. Humans. Male. Middle Aged

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  • (PMID = 16434841.001).
  • [ISSN] 0040-8727
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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69. Cueva RA, Mastrodimos B: Approach design and closure techniques to minimize cerebrospinal fluid leak after cerebellopontine angle tumor surgery. Otol Neurotol; 2005 Nov;26(6):1176-81
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  • [Title] Approach design and closure techniques to minimize cerebrospinal fluid leak after cerebellopontine angle tumor surgery.
  • OBJECTIVE: The purpose of the study was to identify specific aspects of surgical approach design and closure technique aimed at reducing the incidence of cerebrospinal fluid leak after cerebellopontine angle tumor surgery.
  • PATIENTS: All patients undergoing cerebellopontine angle tumor surgery at the study institution from January 1996 through September 2004.
  • Tumor types in descending order of frequency were as follows: acoustic neuroma, 244; cerebellopontine angle meningiomas, 33; petroclival meningiomas, 32; foramen magnum meningiomas, 10; epidermoid tumors, 9; facial nerve tumors, 6; hemangiopericytomas, 3; schwannomas of glossopharyngeal/spinal accessory nerves, 3; and unusual internal auditory canal tumors, 3.
  • Surgical approaches used for tumor resection included translabyrinthine, retrosigmoid, combined transpetrosal, far lateral/transcondylar, middle cranial fossa, and extended middle cranial fossa.

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  • (PMID = 16272937.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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70. Rodriguez FJ, Atkinson JL, Giannini C: Massive sellar and parasellar schwannoma. Arch Neurol; 2007 Aug;64(8):1198-9
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  • [Title] Massive sellar and parasellar schwannoma.
  • [MeSH-major] Neurilemmoma / diagnosis. Pituitary Neoplasms / diagnosis

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  • (PMID = 17698713.001).
  • [ISSN] 0003-9942
  • [Journal-full-title] Archives of neurology
  • [ISO-abbreviation] Arch. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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71. Gómez García I, Rodríguez Patrón R, Conde Someso S, Sanz Mayayo E, Quicios Dorado C, Palmeiro A: [Benign retroperitoneal schwannoma. Incidental diagnostic in patient with hematuria of the percusionist]. Actas Urol Esp; 2005 May;29(5):511-5
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  • [Title] [Benign retroperitoneal schwannoma. Incidental diagnostic in patient with hematuria of the percusionist].
  • [Transliterated title] Schwannoma retroperitoneal benigno. Diagnostico incidental en paciente con hematuria del percusionista.
  • The incidence of retroperitoneal primitive tumour varies from the 0.3 to 3%.
  • The sarcomas suppose the group but it frequents of retroperitoneal tumour, being the Schwannoma an unusual tumour with an incidence from 1% to 50% of the retroperitoneal primary tumours.
  • The schwannoma also denominated neurinoma or neurolenoma, it is a derived tumour of the cells of Schwann of the outlying nerves.
  • [MeSH-major] Hematuria / etiology. Neurilemmoma / complications. Retroperitoneal Neoplasms / complications

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  • (PMID = 16013798.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas espanolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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72. Dagain A, Dulou R, Lahutte M, Dutertre G, Pouit B, Delmas JM, Camparo P, Pernot P: [Extradural spinal meningioma: case report]. Neurochirurgie; 2009 Dec;55(6):565-8
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  • Epidural meningiomas are infrequent intraspinal tumors that can be easily confused with malignant neoplasms or spinal schwannomas.
  • CASE: A 62-year-old man with a previous history of malignant disease presented with back pain and weakness of the lower limbs.
  • CONCLUSION: Purely extradural spinal meningiomas can mimic metastatic tumors or schwannomas.

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  • (PMID = 18817937.001).
  • [ISSN] 1773-0619
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Contrast Media; AU0V1LM3JT / Gadolinium
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73. Jung TY, Jung S, Kim IY, Kang SS: Intracisternal schwannoma of the spinal accessory nerve: a case report. Skull Base; 2006 Aug;16(3):175-9
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  • [Title] Intracisternal schwannoma of the spinal accessory nerve: a case report.
  • We report the details of a patient with an intracisternal schwannoma that developed from the spinal accessory nerve.
  • The tumor arose from one rootlet of the right accessory nerve and histological examination confirmed the diagnosis of a schwannoma.
  • Removal of the schwannoma did not result in a significant neurological deficit.

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  • [Cites] Acta Neurochir (Wien). 1975;31(3-4):201-21 [1081330.001]
  • [Cites] Neurosurgery. 1991 Sep;29(3):455-9 [1922718.001]
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  • (PMID = 17268591.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1586173
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74. Fiscina F, Gouveris H, Mann W: Influence of nerve branch of origin and extracanalicular extension of the tumor on hearing after middle fossa removal of vestibular schwannoma. Acta Otolaryngol; 2007 Oct;127(10):1058-61
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  • [Title] Influence of nerve branch of origin and extracanalicular extension of the tumor on hearing after middle fossa removal of vestibular schwannoma.
  • CONCLUSION: Neither nerve branch of origin nor extracanalicular (up to 1 cm) extension of a vestibular schwannoma (VS) influence the postoperative hearing outcome in patients operated via a middle cranial fossa (MCF) approach.
  • OBJECTIVE: To test whether the nerve branch of tumor origin and an extracanalicular, up to 1 cm, tumor extension influences hearing outcome after MCF VS surgery.
  • Twenty patients had a superior vestibular nerve (SVN) tumor and 27 patients had an inferior vestibular nerve (IVN) tumor.
  • Thirty-four patients had a purely intracanalicular (IC) tumor and 16 patients had an extracanalicular extension in the cerebello-pontine angle.
  • RESULTS: Neither vestibular nerve branch of origin nor extracanalicular tumor extension (up to 1 cm) caused any significant difference in the degree of postoperative hearing change at any of the tested PTA frequencies.

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  • (PMID = 17851965.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Norway
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75. Scheller C, Richter HP, Scheuerle A, Kretschmer T, König RW, Antoniadis G: Intraneural perineuriomas; a rare entity. Clinical, surgical and neuropathological details in the management of these lesions. Zentralbl Neurochir; 2008 Aug;69(3):134-8
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  • OBJECTIVE: Perineuriomas are rare benign peripheral nerve sheath tumors, which have only been included in the WHO classification system since 2000.
  • Two of the four patients showed a partial improvement of their motor and sensorial nerve deficits in the long-term follow-up following complete tumor resection and interpositional autologous nerve grafts.
  • [MeSH-major] Nervous System Neoplasms / pathology. Nervous System Neoplasms / surgery. Neurilemmoma / pathology. Neurilemmoma / surgery

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  • (PMID = 18666052.001).
  • [ISSN] 0044-4251
  • [Journal-full-title] Zentralblatt für Neurochirurgie
  • [ISO-abbreviation] Zentralbl. Neurochir.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / S100 Proteins
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76. Takei H, Schmiege L, Buckleair L, Goodman JC, Powell SZ: Intracerebral schwannoma clinically and radiologically mimicking meningioma. Pathol Int; 2005 Aug;55(8):514-9
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  • [Title] Intracerebral schwannoma clinically and radiologically mimicking meningioma.
  • A case of intracerebral schwannoma (ICS) occurring in a 33-year-old woman is presented.
  • Microscopically, the tumor demonstrated classic biphasic Antoni type A and B patterns, admixed with degenerative changes.
  • Immunohistochemically, the neoplastic cells were positive for S-100 protein (diffuse and strong), CD34 (primarily in Antoni B areas), glial fibrillary acidic protein (GFAP; weak and diffuse) and calretinin (mainly in Antoni A areas), while none was positive for CD31, estrogen and progesterone receptors, bcl-2, or epithelial membrane antigen (EMA).
  • The differential diagnosis includes fibrous meningioma, solitary fibrous tumor, and ICS.
  • [MeSH-major] Brain Neoplasms / pathology. Meningeal Neoplasms / pathology. Meningioma / pathology. Neurilemmoma / pathology

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  • (PMID = 15998381.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / Glial Fibrillary Acidic Protein; 0 / S100 Calcium Binding Protein G; 0 / S100 Proteins
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77. Amit A, Achawal S, Dorward N: Pituitary macro adenoma and vestibular schwannoma: a case report of dual intracranial pathologies. Br J Neurosurg; 2008 Oct;22(5):695-6
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  • [Title] Pituitary macro adenoma and vestibular schwannoma: a case report of dual intracranial pathologies.
  • A case of dual intracranial benign tumours comprising pituitary adenoma and vestibular schwannoma is described.
  • The aetiology and genetic association of these pathologies is explored and the literature of multiple intracranial tumours of different cell types is reviewed.

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  • (PMID = 18661423.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 4
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78. Kohama M, Murakami K, Endo T, Watanabe M, Tominaga T: Surgical and histological observations of trochlear neurinoma: case report. Neurol Med Chir (Tokyo); 2009 May;49(5):217-20
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  • [Title] Surgical and histological observations of trochlear neurinoma: case report.
  • A 47-year-old woman presented with an extremely rare case of trochlear nerve neurinoma manifesting as left hemiparesis.
  • Magnetic resonance imaging demonstrated a cystic tumor, 4 cm in diameter, in the right ambient and cerebellopontine cisterns, compressing the midbrain and upper pons.
  • The preoperative diagnosis was trigeminal neurinoma.
  • However, the tumor was identified arising from the trochlear nerve, and was totally removed via the posterior transpetrosal approach.
  • The histological diagnosis was neurinoma.
  • Preoperative diagnosis of trochlear neurinoma must distinguish the neurological presentations of trochlear and trigeminal neurinomas and to analyze the microanatomy of the tumor and skull base structures on neuroimaging.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neurilemmoma / surgery. Trochlear Nerve Diseases / surgery

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  • (PMID = 19465794.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 32
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79. Novák P, Németh I, Hamar S, Tiszlavicz L, Szalai L, Sonkodi I, Nagy K: [Clear cell adenocarcinoma of the tongue. Coincidence or distant metastasis?]. Fogorv Sz; 2009 Oct;102(5):183-6
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  • [Title] [Clear cell adenocarcinoma of the tongue. Coincidence or distant metastasis?].
  • Clear cell adenocarcinoma represents 1% of malignant tumors of the salivary glands.
  • Her past medical history included right nephrectomy of renal cell carcinoma, seven years before the tongue tumor.
  • The initial orofacial clinical examination suspected lipoma, neurinoma or distant metastasis of the renal cell carcinoma.
  • The histomorphological analysis of the resected tongue tumor showed similar clear cell adenocarcinoma mimicking the phenotype of renal cell carcinoma but detailed immunohistochemical analysis proved the primary origin of tongue indicating second primary metachronous malignant tumor.
  • [MeSH-major] Adenocarcinoma, Clear Cell. Neoplasms, Second Primary. Tongue Neoplasms
  • [MeSH-minor] Carcinoma, Renal Cell / surgery. Female. Humans. Kidney Neoplasms / surgery. Middle Aged. Nephrectomy

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  • (PMID = 20000197.001).
  • [ISSN] 0015-5314
  • [Journal-full-title] Fogorvosi szemle
  • [ISO-abbreviation] Fogorv Sz
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
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80. Bisceglia M, Spagnolo D, Galliani C, Fisher C, Suster S, Kazakov DV, Cooper K, Michal M: Tumoral, quasitumoral and pseudotumoral lesions of the superficial and somatic soft tissue: new entities and new variants of old entities recorded during the last 25 years. Part XII: appendix. Pathologica; 2006 Aug;98(4):239-98
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  • Detailed clinicomorphological and differential diagnostic features of approximately sixty entities were chosen on the basis of their clinical significance and morphologic distinctiveness.
  • The series included fibrous and myofibroblastic tumors (e.g. solitary fibrous tumor, high grade classic and pigmented dermatofibrosarcoma protuberans, inflammatory myofibroblastic tumor and myofibrosarcomas), fibromyxoid and fibrohistiocytic neoplasms (e.g., Evans' tumor, phosphaturic mesenchymal tumor, inflammatory myxohyaline tumor), special adipocytic/vascular/and smooth muscle lesions (e.g., chondroid lipoma, Dabska's tumor, ST hemangioblastoma, lipoleiomyosarcoma), epithelioid mesenchymal malignancies of diverse lineages (e.g., epithelioid liposarcoma, proximal-type epithelioid sarcoma, neuroendocrine extraskeletal chondromyxoid sarcoma), ST Ewing's tumor and peripheral nerve sheath tumors (perineuriomas and pigmented and rosetting tumors of the schwannoma/neurofibroma group), extranodal dendritic or histiocytic proliferative processes (follicular dendritic cell sarcoma, Rosai-Dorfman disease, Castleman's disease, and plexiform xanthomatous tumor), and tumors with myoepithelial differentiation.
  • The section devoted to selected pseudotumoral entities considered representatives of the hamartoma group (neural fibrolipomatous hamartoma, ectopic hamartomatous thymoma, rudimentary meningocele), metabolic diseases (amyloid tumor, nephrogenic fibrosing dermopathy, tophaceous pseudogout, pseudoinfiltrative parathyromatosis), stromal tissue reactions to trauma (fibroosseous pseudotumors of digits) and infections (bacillary angiomatosis), and normal organs (glomus coccygeum).

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  • (PMID = 17175794.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 272
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81. Plaza JA, Wakely PE Jr, Suster S: Lipoblastic nerve sheath tumors: report of a distinctive variant of neural soft tissue neoplasm with adipocytic differentiation. Am J Surg Pathol; 2006 Mar;30(3):337-44
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  • Benign nerve sheath tumors of soft tissue can occasionally adopt unusual or unfamiliar morphologic appearances that may introduce difficulties for diagnosis, such as multinucleation, bizarre nuclei, intranuclear vacuoles, and other degenerative changes.
  • Tumor cells adopting a signet-ring or lipoblast-like configuration, however, are mostly associated with epithelial malignancies, liposarcoma and melanoma, and have been only rarely observed in spindle cell tumors of soft tissue.
  • We report 5 cases of benign nerve sheath neoplasms that displayed prominent signet-ring cells with lipoblast-like features.
  • Four tumors predominantly showed features of schwannoma and one of neurofibroma; however, intimately admixed with the spindle cell population, there were also numerous scattered mature adipocytes as well as lipoblast-like cells displaying a signet-ring cell appearance.
  • Neurogenic tumors should be added in the differential diagnosis of spindle cell tumors capable of displaying prominent signet-ring cell features.
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Carcinoma, Signet Ring Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission. Middle Aged

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  • (PMID = 16538053.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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82. Komatsu D, Koide N, Hiraga R, Furuya N, Akamatsu T, Uehara T, Miyagawa S: Gastric schwannoma exhibiting increased fluorodeoxyglucose uptake. Gastric Cancer; 2009;12(4):225-8
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  • [Title] Gastric schwannoma exhibiting increased fluorodeoxyglucose uptake.
  • This is the first case of gastric schwannoma that exhibited increased accumulation of [(18)F] fluorodeoxyglucose (FDG) on positron emission tomography (PET) imaging.
  • The patient was a 60-year-old woman in whom esophagogastroduodenoscopy showed a submucosal tumor, about 25 mm in size, in the upper body of the stomach, with ulceration at the top of the tumor.
  • The specimen taken from the tumor showed only inflammatory degenerative tissue.
  • Abdominal computed tomography revealed a tumor in the upper body of the stomach.
  • FDG-PET showed FDG uptake (standardized uptake value [SUV] max 5.8) coincident with the tumor.
  • Hence, the tumor was diagnosed initially as a gastrointestinal stromal tumor of the stomach.
  • Pathological examination showed that the tumor consisted of spindle cells with large nuclei, and mitosis was absent.
  • The Ki-67 labeling index of the tumor cells was 4%.
  • Immunohistochemically, the tumor cells showed a positive reaction for S-100 protein, whereas they were negative for KIT, CD 34, and alpha-smooth muscle actin protein.
  • The tumor was diagnosed as a benign gastric schwannoma.
  • Gastric schwannoma should be included in the differential diagnosis of submucosal tumors of the stomach with FDG uptake.
  • [MeSH-major] Fluorodeoxyglucose F18. Neurilemmoma / diagnosis. Radiopharmaceuticals. Stomach Neoplasms / diagnosis

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  • [Cites] Clin Radiol. 2008 May;63(5):536-42 [18374717.001]
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  • (PMID = 20047128.001).
  • [ISSN] 1436-3305
  • [Journal-full-title] Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
  • [ISO-abbreviation] Gastric Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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83. Phaniendra V, Pratinidhi SK, Renuka IV: Silent intratemporal facial nerve schwannoma associated with Chronic Suppurative Otitis Media: A rare presentation. Indian J Otolaryngol Head Neck Surg; 2007 Mar;59(1):53-5
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  • [Title] Silent intratemporal facial nerve schwannoma associated with Chronic Suppurative Otitis Media: A rare presentation.
  • Facial palsy is a common manifestation of intratemporal facial nerve schwannoma.
  • Review of English literature describes intratemporal facial nerve schwannoma presenting as vertigo, tinnitus (without facial palsy) which were diagnosed on CT scan or MRI of temporal bone.
  • We are presenting two cases of asymptomatic facial nerve schwannoma without facial palsy presenting only as Chronic Suppurative Otitis Media (CSOM), which were diagnosed incidentally during surgery.

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  • [Cites] ORL J Otorhinolaryngol Relat Spec. 1978;40(5):254-62 [572027.001]
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  • (PMID = 23120387.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3451712
  • [Keywords] NOTNLM ; CSOM / Facial paralysis / Intratemporal facial nerve / Schwannoma
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84. Flaiz C, Utermark T, Parkinson DB, Poetsch A, Hanemann CO: Impaired intercellular adhesion and immature adherens junctions in merlin-deficient human primary schwannoma cells. Glia; 2008 Apr;56(5):506-15
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  • [Title] Impaired intercellular adhesion and immature adherens junctions in merlin-deficient human primary schwannoma cells.
  • Schwannomas that occur spontaneously or in patients with neurofibromatosis Type 2, lack both alleles for the tumor suppressor and plasma membrane-cytoskeleton linker merlin.
  • We have shown that human primary schwannoma cells display activation of the RhoGTPases Rac1 and Cdc42 which results in highly dynamic and ongoing protrusive activity like ruffling.
  • We tested if there is a connection between Rac1-induced ongoing ruffling and the maintenance, stabilization and functionality of adherens junctions and if this is of relevance in human, merlin-deficient schwannoma cells.
  • We show intense ongoing ruffling is not limited to membranes of single human primary schwannoma cells, but occurs also in membranes of contacting cells, even when confluent.
  • Live cell imaging shows that newly formed contacts are released after a short time, suggesting disturbed formation or stabilization of adherens junctions.
  • Morphology, high phospho-tyrosine levels and cortactin staining indicate that adherens junctions are immature in human primary schwannoma cells, whereas they display characteristics of mature adherens junctions in human primary Schwann cells.
  • When merlin is reintroduced, human primary schwannoma cells show only initial ruffling in contacting cells and adherens junctions appear more mature.
  • We therefore propose that ongoing Rac-induced ruffling causes immature adherens junctions and leads to impaired, nonfunctional intercellular adhesion in aggregation assays in merlin-deficient schwannoma cells that could be an explanation for increased proliferation rates due to loss of contact inhibition or tumor development in general.
  • [MeSH-major] Adherens Junctions / pathology. Cell Adhesion Molecules / metabolism. Neurilemmoma / metabolism. Neurilemmoma / pathology. Neurofibromin 2 / deficiency
  • [MeSH-minor] Cell Adhesion / genetics. Cells, Cultured. Gene Expression Regulation, Neoplastic / genetics. Gene Transfer Techniques. Green Fluorescent Proteins / genetics. Green Fluorescent Proteins / metabolism. Humans. Neurofibromatosis 2 / pathology. Peripheral Nervous System Neoplasms / pathology. Protein Transport / genetics. Schwann Cells / metabolism. Schwann Cells / pathology. Time Factors. Tyrosine / metabolism. cdc42 GTP-Binding Protein / metabolism. rac1 GTP-Binding Protein / metabolism

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  • (PMID = 18240308.001).
  • [ISSN] 0894-1491
  • [Journal-full-title] Glia
  • [ISO-abbreviation] Glia
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Adhesion Molecules; 0 / Neurofibromin 2; 0 / RAC1 protein, human; 147336-22-9 / Green Fluorescent Proteins; 42HK56048U / Tyrosine; EC 3.6.5.2 / cdc42 GTP-Binding Protein; EC 3.6.5.2 / rac1 GTP-Binding Protein
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85. García-Toral R, Aguilar-Padilla L, Gardoqui-Zurita F, Prieto-Murguía E, Vásquez-Fernández F: [Giant mediastinal neurilemoma. A case report]. Rev Med Inst Mex Seguro Soc; 2009 May-Jun;47(3):327-30
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  • [Title] [Giant mediastinal neurilemoma. A case report].
  • [Transliterated title] Neurilemoma mediastinal gigante. Presentación de un caso.
  • BACKGROUND: Mediastinal neurilemmoma is an infrequent and a big size neoplasm in the posterior mediastinum.
  • CLINICAL CASE: We report a case in a 29-year-old male with a giant mediastinal neurilemmoma.
  • CONCLUSIONS: The giant mediastinal neurilemmoma is a benign and asymptomatic neoplasm in most cases.
  • [MeSH-major] Mediastinal Neoplasms. Neurilemmoma

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  • (PMID = 20141665.001).
  • [ISSN] 0443-5117
  • [Journal-full-title] Revista médica del Instituto Mexicano del Seguro Social
  • [ISO-abbreviation] Rev Med Inst Mex Seguro Soc
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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86. Lewin MR, Dilworth HP, Abu Alfa AK, Epstein JI, Montgomery E: Mucosal benign epithelioid nerve sheath tumors. Am J Surg Pathol; 2005 Oct;29(10):1310-5
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  • [Title] Mucosal benign epithelioid nerve sheath tumors.
  • In a series of mucosal biopsies, we have encountered a distinct subset of mucosal peripheral nerve sheath tumors characterized by small epithelioid cells and a benign clinical course.
  • Such epithelioid nerve sheath tumors have been observed as a component of a larger study of colorectal "schwannomas," but herein we describe them in detail.
  • On follow-up of 5 patients, none has had any symptoms or recurrence of disease.
  • These lesions are often discovered incidentally and have a benign clinical course.

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  • (PMID = 16160473.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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87. Rawal A, Yin Q, Roebuck M, Sinopidis C, Kalogrianitis S, Helliwell TR, Frostick S: Atypical and malignant peripheral nerve-sheath tumors of the brachial plexus: report of three cases and review of the literature. Microsurgery; 2006;26(2):80-6
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  • Tumor involvement of the brachial plexus is uncommon.
  • The most common intrinsic neoplasms involving the brachial plexus are benign neurilemmomas and neurofibromas that are usually associated with neurofibromatosis-1 (NF-1).
  • MPNST are intermediate or high-grade sarcomas with a high risk of local and distant spread.

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  • (PMID = 16538633.001).
  • [ISSN] 0738-1085
  • [Journal-full-title] Microsurgery
  • [ISO-abbreviation] Microsurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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88. Shelfer J, Zapala D, Lundy L: Fall risk, vestibular schwannoma, and anticoagulation therapy. J Am Acad Audiol; 2008 Mar;19(3):237-45
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fall risk, vestibular schwannoma, and anticoagulation therapy.
  • A case is presented of an 87-year-old female with balance problems, in part from a small unilateral vestibular schwannoma.

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  • (PMID = 18672652.001).
  • [ISSN] 1050-0545
  • [Journal-full-title] Journal of the American Academy of Audiology
  • [ISO-abbreviation] J Am Acad Audiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Anticoagulants; 5Q7ZVV76EI / Warfarin
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89. Oshima Y, Miyoshi K, Mikami Y, Kawamura N: Pelvic ring reconstruction with a vascularized pedicle iliac bone graft for a large sacral schwannoma. J Spinal Disord Tech; 2005 Apr;18(2):200-2
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  • [Title] Pelvic ring reconstruction with a vascularized pedicle iliac bone graft for a large sacral schwannoma.
  • A case of pelvic ring reconstruction with a vascularized pedicle iliac bone graft for removal of a huge sacral schwannoma is reported.
  • We applied a vascularized pedicle iliac bone graft to the pelvic ring reconstruction after resection of a huge sacral schwannoma.
  • [MeSH-major] Bone Transplantation / methods. Ilium / transplantation. Neurilemmoma / surgery. Pelvic Neoplasms / surgery. Reconstructive Surgical Procedures / methods. Sacrum / surgery

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  • (PMID = 15800443.001).
  • [ISSN] 1536-0652
  • [Journal-full-title] Journal of spinal disorders & techniques
  • [ISO-abbreviation] J Spinal Disord Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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90. Jacob A, Lee TX, Neff BA, Miller S, Welling B, Chang LS: Phosphatidylinositol 3-kinase/AKT pathway activation in human vestibular schwannoma. Otol Neurotol; 2008 Jan;29(1):58-68
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  • [Title] Phosphatidylinositol 3-kinase/AKT pathway activation in human vestibular schwannoma.
  • HYPOTHESIS: The neurofibromatosis 2 gene, which encodes the tumor suppressor protein merlin, is frequently mutated in vestibular schwannomas (VS).
  • Activation of the PI3 kinase/AKT pathway increases cell survival and cell proliferation and has been observed in a variety of human cancers.
  • METHODS: Complementary deoxyribonucleic acid microarrays were performed using cultured Schwann cells, 4 VS specimens, and 2 paired normal vestibular nerves.
  • [MeSH-minor] Blotting, Western. Colforsin / pharmacology. DNA, Neoplasm / genetics. Humans. Immunohistochemistry. Oligonucleotide Array Sequence Analysis. Paraffin Embedding. Tubulin / genetics. Tumor Cells, Cultured. Xenograft Model Antitumor Assays

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  • (PMID = 18199958.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Tubulin; 1F7A44V6OU / Colforsin; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Oncogene Protein v-akt
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91. Gaitero L, Añor S, Fondevila D, Pumarola M: Canine cutaneous spindle cell tumours with features of peripheral nerve sheath tumours: a histopathological and immunohistochemical study. J Comp Pathol; 2008 Jul;139(1):16-23
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  • [Title] Canine cutaneous spindle cell tumours with features of peripheral nerve sheath tumours: a histopathological and immunohistochemical study.
  • In veterinary medicine, the term peripheral nerve sheath tumour is usually restricted to neoplasms that are closely associated with an identified nerve.
  • Thirty-three cases of canine cutaneous tumours previously classified as spindle cell tumours with features resembling peripheral nerve sheath tumours were examined.
  • Two histological patterns were identified: dense areas of spindle shaped cells resembling the Antoni A pattern and less cellular areas with more pleomorphic cells resembling the Antoni B pattern.
  • Glial fibrillary acidic protein was only expressed within the cytoplasm of some large multinucleated cells in one tumour.
  • These findings suggest that any cutaneous tumour with one of the two histopathological patterns described above should be described as a cutaneous peripheral nerve sheath tumour and that expression of S-100, laminin and collagen IV may be used to define a schwannoma.

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  • (PMID = 18514218.001).
  • [ISSN] 0021-9975
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Collagen Type IV; 0 / Glial Fibrillary Acidic Protein; 0 / Laminin; 0 / S100 Proteins; 0 / Vimentin
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92. Galbis Caravajal JM, Sales Badía G, Fuster Diana CA, Mallent Añón J, Pallardó Calatayud Y, Rodríguez Paniagua JM: [Oncoplastic surgery for thoracic wall tumours]. Clin Transl Oncol; 2005 Sep;7(8):351-5
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  • MATERIAL AND METHODS: We present a series of 14 patients who needed extensive resection of the thoracic wall (external and/or 3 or more ribs) with disease-free margins and reconstruction with prostheses (7 with polytetrafluoroethylene [PTFE(R)] and 7 with the Sandwich Marlex-Methyl Metacrylate) technique with additional covering with muscle-skin flaps (6 pectoral, 5 recto-anterior, 3 dorsal) pedicled during the same surgical intervention.
  • RESULTS: The aetiology of the extirpated tumours, following pathology assessment, were: 4 chondrosarcoma, 3 metastatic sternum, 2 breast cancer relapse, 1 desmoid tumour, 1 neurofibrosarcoma, 1 rhabdomiosarcoma, 1 malignant schwannoma and 1 radiation induced sarcoma.
  • One patient died from complications and another 4 from disease progression before the conclusion of the study follow-up (3-22 months).

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  • (PMID = 16185604.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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93. Kuo YH, Roos D, Brophy BP: Linear accelerator radiosurgery for treatment of vestibular schwannomas in neurofibromatosis 2. J Clin Neurosci; 2008 Jul;15(7):744-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Linear accelerator radiosurgery for treatment of vestibular schwannomas in neurofibromatosis 2.
  • Management of vestibular schwannomas in patients with neurofibromatosis 2 (NF2) balances growth control against preservation of hearing with the primary aim of maintaining patient quality of life.
  • Previous studies on the efficacy of stereotactic radiosurgery for vestibular schwannomas in NF2 have reported results from delivery by Gamma Knife systems.
  • Modelling studies suggest that lesional conformality is superior with Gamma Knife, but clinical studies on sporadic vestibular schwannomas show equivalent results between the two systems.
  • Our experience with LINAC radiosurgery in NF2 reported here shows good long-term growth control in four patients with vestibular schwannomas.

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  • (PMID = 18403208.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Scotland
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94. James MF, Han S, Polizzano C, Plotkin SR, Manning BD, Stemmer-Rachamimov AO, Gusella JF, Ramesh V: NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth. Mol Cell Biol; 2009 Aug;29(15):4250-61
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  • [Title] NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth.
  • Inactivating mutations of the neurofibromatosis 2 (NF2) gene, NF2, result predominantly in benign neurological tumors, schwannomas and meningiomas, in humans; however, mutations in murine Nf2 lead to a broad spectrum of cancerous tumors.
  • The tumor-suppressive function of the NF2 protein, merlin, a membrane-cytoskeleton linker, remains unclear.
  • Here, we identify the mammalian target of rapamycin complex 1 (mTORC1) as a novel mediator of merlin's tumor suppressor activity.
  • Merlin-deficient human meningioma cells and merlin knockdown arachnoidal cells, the nonneoplastic cell counterparts of meningiomas, exhibit rapamycin-sensitive constitutive mTORC1 activation and increased growth.

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  • (PMID = 19451225.001).
  • [ISSN] 1098-5549
  • [Journal-full-title] Molecular and cellular biology
  • [ISO-abbreviation] Mol. Cell. Biol.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / P30 NS045776; United States / NINDS NIH HHS / NS / NS 045776; United States / NIMH NIH HHS / MH / R21 MH079213; United States / NIMH NIH HHS / MH / MH 079213; United States / NINDS NIH HHS / NS / P01 NS024279; United States / NCI NIH HHS / CA / R01 CA122617-04; United States / NINDS NIH HHS / NS / NS 024279; United States / NCI NIH HHS / CA / CA122617-04; United States / NCI NIH HHS / CA / R01 CA122617
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Multiprotein Complexes; 0 / Neurofibromin 2; 0 / Proteins; 0 / RNA, Small Interfering; 0 / Transcription Factors; 0 / mechanistic target of rapamycin complex 1; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; W36ZG6FT64 / Sirolimus
  • [Other-IDs] NLM/ PMC2715803
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95. Roche PH, Ribeiro T, Khalil M, Soumare O, Thomassin JM, Pellet W: Recurrence of vestibular schwannomas after surgery. Prog Neurol Surg; 2008;21:89-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrence of vestibular schwannomas after surgery.
  • The issue of recurrence of vestibular schwannomas is poorly studied by the surgical literature and is probably underestimated.
  • Management of recurrence depends on the tumor size and patient's condition.
  • Prospective long-term follow-up studies using serial MR imaging after radical removal should bring reliable data about the incidence of vestibular schwannoma recurrence.

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  • (PMID = 18810204.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 7
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96. Sen A, Green KM, Khan MI, Saeed SR, Ramsden RT: Cerebrospinal fluid leak rate after the use of BioGlue in translabyrinthine vestibular schwannoma surgery: a prospective study. Otol Neurotol; 2006 Jan;27(1):102-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cerebrospinal fluid leak rate after the use of BioGlue in translabyrinthine vestibular schwannoma surgery: a prospective study.
  • OBJECTIVE: To determine the effectiveness of BioGlue surgical adhesive in dural and middle ear closure after translabyrinthine vestibular schwannoma surgery.
  • INTERVENTIONS: We studied the use of BioGlue and its possible effect on further reducing our department's cerebrospinal fluid leak rate for translabyrinthine vestibular schwannoma surgery.
  • CONCLUSION: Our preliminary prospective study of the use of BioGlue for dural and middle ear closure in translabyrinthine vestibular schwannoma surgery demonstrated poor results.
  • The high cerebrospinal fluid leak rate associated with the unusual presentations and ensuing management difficulties in controlling these leaks lead us to recommend that BioGlue not be used in translabyrinthine vestibular schwannoma surgery.
  • [MeSH-major] Cerebrospinal Fluid Otorrhea / prevention & control. Cranial Nerve Neoplasms / surgery. Neurilemmoma / surgery. Proteins / therapeutic use. Vestibular Nerve. Vestibulocochlear Nerve Diseases / surgery

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  • [CommentIn] Otol Neurotol. 2007 Oct;28(7):992 [17909439.001]
  • [ErratumIn] Otol Neurotol. 2006 Feb;27(2):298
  • (PMID = 16371855.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bio-glue; 0 / Proteins
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97. Ambrosio A, Scaramuzzi M, Torlontano M, Di Sebastiano P: [Laparoscopic adrenalectomy: analysis of 65 cases]. Chir Ital; 2007 Nov-Dec;59(6):853-6
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  • On the basis of our analysis of the results we feel that we can safely claim, in agreement with the literature, that laparoscopic cholecystectomy is the treatment of choice for benign disease and that lesions measuring > 6 cm can be dealt with by surgical teams with good laparoscopic experience.
  • [MeSH-major] Adenoma / surgery. Adrenal Gland Neoplasms / surgery. Adrenal Hyperplasia, Congenital / surgery. Adrenalectomy. Hemangioma / surgery. Laparoscopy. Myelolipoma / surgery. Neurilemmoma / surgery. Pheochromocytoma / surgery

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  • (PMID = 18360991.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Italy
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98. Yeager S: Ventriculostomy for treatment of persistent cervical cerebral spinal fluid leak after excision of cervical schwannoma: a case study. J Neurosci Nurs; 2008 Apr;40(2):116-8
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  • [Title] Ventriculostomy for treatment of persistent cervical cerebral spinal fluid leak after excision of cervical schwannoma: a case study.
  • Given the tumor's attachment to dural tissue, cerebrospinal fluid (CSF) leaks are an anticipated challenge.
  • A 59-year-old female admitted for surgical excision of a cervical schwannoma developed a persistent postoperative CSF leak.
  • Ventriculostomy is a viable option for treatment of persistent CSF wound drainage after excision of cervical schwannoma surgery.
  • [MeSH-major] Neurilemmoma / surgery. Spinal Cord Neoplasms / surgery. Subdural Effusion / surgery. Surgical Wound Dehiscence / surgery. Ventriculostomy

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  • (PMID = 18481742.001).
  • [ISSN] 0888-0395
  • [Journal-full-title] The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses
  • [ISO-abbreviation] J Neurosci Nurs
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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99. Otto SR, Shannon RV, Wilkinson EP, Hitselberger WE, McCreery DB, Moore JK, Brackmann DE: Audiologic outcomes with the penetrating electrode auditory brainstem implant. Otol Neurotol; 2008 Dec;29(8):1147-54
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  • PATIENTS AND PROTOCOL: In a prospective clinical trial, 10 individuals, all with neurofibromatosis type 2, received a PABI after vestibular schwannoma removal via a translabyrinthine approach.

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  • (PMID = 18931643.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Grant] United States / NIDCD NIH HHS / DC / N01-DC-1-2105; United States / NIDCD NIH HHS / DC / N01-DC-4-0005
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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100. Ohwada S, Hamada K, Kawate S, Sunose Y, Tomizawa N, Yamada T, Okabe T, Ogawa T, Sato Y: Left renal vein graft for vascular reconstruction in abdominal malignancy. World J Surg; 2007 Jun;31(6):1215-20
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  • METHODS: A total of 113 patients underwent vascular resection including the PV (42 patients), IVC (68 patients), and HV (3 patients) for hepatobiliary-pancreatic or abdominal tumor resection.
  • The IVC was partially resected in 1 patient with advanced colon cancer and 1 with malignant schwannoma.
  • One patient who underwent extended right hepatectomy and pancreaticoduodenectomy died of liver failure in the hospital.
  • The serum creatinine level after surgery did not deteriorate except in the one patient who died in the hospital.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Bile Duct Neoplasms / mortality. Bile Duct Neoplasms / pathology. Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic / pathology. Bile Ducts, Intrahepatic / surgery. Carcinoma, Hepatocellular / mortality. Carcinoma, Hepatocellular / pathology. Carcinoma, Hepatocellular / surgery. Carcinoma, Renal Cell / mortality. Carcinoma, Renal Cell / pathology. Carcinoma, Renal Cell / surgery. Cholangiocarcinoma / mortality. Cholangiocarcinoma / pathology. Cholangiocarcinoma / surgery. Female. Follow-Up Studies. Hepatectomy. Hospital Mortality. Humans. Kidney Neoplasms / mortality. Kidney Neoplasms / pathology. Kidney Neoplasms / surgery. Liver Neoplasms / mortality. Liver Neoplasms / pathology. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Male. Microsurgery. Middle Aged. Neoplasm Invasiveness. Pancreatic Neoplasms / mortality. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy. Postoperative Complications / mortality. Tomography, X-Ray Computed. Vascular Patency / physiology

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  • (PMID = 17453283.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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