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1. Fine RE, Staren ED: Percutaneous radiofrequency-assisted excision of fibroadenomas. Am J Surg; 2006 Oct;192(4):545-7
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  • INTRODUCTION: Fibroadenomas are a frequently encountered benign tumor that will occur in approximately 10% of women during their lifetime.
  • An 18-month retrospective analysis was undertaken to evaluate the utilization of a new radiofrequency-assisted biopsy device in the successful removal and continued absence of histologically confirmed fibroadenomas on 4- to 6-month follow-up imaging.
  • On pathologic examination, the tumors ranged in size from 6 to 27 mm (mean diameter, 14 mm) and weighed from 0.6 to 2.0 g (mean weight, 1.0 g).
  • [MeSH-major] Breast Neoplasms / surgery. Electrosurgery / instrumentation. Fibroadenoma / surgery

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  • (PMID = 16978972.001).
  • [ISSN] 0002-9610
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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2. Lagiou P, Georgila C, Samoli E, Lagiou A, Zourna P, Minaki P, Vassilarou D, Papadiamandis I, Sfikas C, Kalapothaki V, Sekeris CE, Trichopoulos D: Estrogen alpha and progesterone receptor expression in the normal mammary epithelium in relation to breast cancer risk. Int J Cancer; 2009 Jan 15;124(2):440-2
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  • In a study in Greece, we determined estrogen alpha and progesterone receptor expression in normal mammary tissue adjacent to the pathological tissue from 267 women with breast cancer and 299 women with benign breast disease.

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  • [Copyright] Copyright (c) 2008 Wiley-Liss, Inc.
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  • (PMID = 18798271.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA089823-02; United States / NCI NIH HHS / CA / R03 CA089823; United States / NCI NIH HHS / CA / CA89823; United States / NCI NIH HHS / CA / R03 CA089823-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; 0 / Estrogens; 0 / Receptors, Progesterone
  • [Other-IDs] NLM/ NIHMS70937; NLM/ PMC2605180
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3. Chen YQ, Zhao CL, Li W: Effect of hypoxia-inducible factor-1alpha on transcription of survivin in non-small cell lung cancer. J Exp Clin Cancer Res; 2009;28:29
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  • [Title] Effect of hypoxia-inducible factor-1alpha on transcription of survivin in non-small cell lung cancer.
  • METHODS: In this study, we investigated the effect of hypoxia-inducible factor-1alpha (HIF-1alpha) on the transcriptional activity of the survivin promoter in non-small cell lung cancer (NSCLC).
  • Immunohistochemical staining was used to detect the expression of survivin and HIF-1alpha in the lung tissue of 120 patients with non-small cell lung cancer (NSCLC) and 40 patients with benign pulmonary disease.
  • In the survivin promoter the putative binding-site for HIF-1alpha, is -19 bpapproximately -16 bp upstream of TSS.
  • We performed site-directed mutagenesis of this binding site, and used luciferase reporter plasmids to determine the relative activity of the survivin promoter in A549 cells.
  • Site directed mutagenesis of the putative binding site for HIF-1alpha in the survivin promoter significantly decreased the activity of the survivin promoter in A549 cells.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / metabolism. Hypoxia-Inducible Factor 1, alpha Subunit / biosynthesis. Lung Neoplasms / metabolism. Microtubule-Associated Proteins / biosynthesis
  • [MeSH-minor] Adult. Aged. Apoptosis / genetics. Binding Sites. Cell Growth Processes / genetics. Cell Hypoxia / genetics. Cell Line, Tumor. Female. Gene Expression Regulation, Neoplastic. Humans. Inhibitor of Apoptosis Proteins. Male. Middle Aged. Mutagenesis, Site-Directed. Promoter Regions, Genetic. RNA Interference. Transcription, Genetic. Transfection

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  • (PMID = 19245702.001).
  • [ISSN] 1756-9966
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins
  • [Other-IDs] NLM/ PMC2663545
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4. Khandani AH, Dunphy CH, Meteesatien P, Dufault DL, Ivanovic M, Shea TC: Glut1 and Glut3 expression in lymphoma and their association with tumor intensity on 18F-fluorodeoxyglucose positron emission tomography. Nucl Med Commun; 2009 Aug;30(8):594-601
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  • [Title] Glut1 and Glut3 expression in lymphoma and their association with tumor intensity on 18F-fluorodeoxyglucose positron emission tomography.
  • OBJECTIVE: To evaluate the expression of glucose transporters (Gluts) 1 and 3 in Hodgkin and nonHodgkin lymphoma and to assess the association between their expression and the tumor intensity on 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET).
  • METHODS: All 31 lymphoma patients in whom the histologic diagnosis was made and who had also undergone a prechemotherapy PET scan at our institution between June 2001 and December 2005 were included in this retrospective study.
  • The percentage of tumor cells in the various lymphoma subtypes was estimated by comparison of hematoxylin and eosin stain with a lineage-associated immunohistochemical stain on the same block of tissue.
  • FDG PET images were reviewed and the tumor intensity was assessed by calculating the maximum standard uptake value (SUVmax).
  • RESULTS: In all 31 cases, tumors were visible on FDG PET and positive for Glut1 and Glut3.
  • More importantly, in 16 of 31 cases (52%), only nonlymphomatous, benign cells expressed Glut1 or Glut3.
  • The nonlymphomatous, benign cells may play an important role in visualization of lymphoma on FDG PET.
  • [MeSH-major] Fluorodeoxyglucose F18. Gene Expression Regulation, Neoplastic. Glucose Transporter Type 1 / metabolism. Glucose Transporter Type 3 / metabolism. Lymphoma / genetics. Lymphoma / radionuclide imaging
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Hodgkin Disease / genetics. Hodgkin Disease / metabolism. Hodgkin Disease / pathology. Hodgkin Disease / radionuclide imaging. Humans. Lymphoma, Non-Hodgkin / genetics. Lymphoma, Non-Hodgkin / metabolism. Lymphoma, Non-Hodgkin / pathology. Lymphoma, Non-Hodgkin / radionuclide imaging. Male. Middle Aged. Positron-Emission Tomography

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  • (PMID = 19536037.001).
  • [ISSN] 1473-5628
  • [Journal-full-title] Nuclear medicine communications
  • [ISO-abbreviation] Nucl Med Commun
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Glucose Transporter Type 1; 0 / Glucose Transporter Type 3; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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5. Pironi D, Vendettuoli M, La Gioia G, Arcieri S, Filippini A: A large Brunner's gland adenoma: an unusual cause of gastrointestinal bleeding. Case report and literature review. Ann Ital Chir; 2010 Mar-Apr;81(2):147-51
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  • Brunner's gland adenoma is a rare benign tumour of the duodenum.
  • We report a rare case of a very large Brunner's gland adenoma in a 38-year-old female presenting with severe anaemia but without obstructive symptoms and detected by ultrasonography.
  • The tumour was managed by surgical removal and during a six month follow-up the patient remained symptom-free without any recurrence.
  • [MeSH-major] Adenoma / complications. Brunner Glands. Duodenal Neoplasms / complications. Gastrointestinal Hemorrhage / etiology

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  • (PMID = 20726394.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 45
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6. Yu YH, Son BK, Jun DW, Kim SH, Jo YJ, Park YS, Hong BW, Joo JE: [A case of desmoid tumor presenting as intra-abdominal abscess]. Korean J Gastroenterol; 2009 May;53(5):315-9
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  • [Title] [A case of desmoid tumor presenting as intra-abdominal abscess].
  • Desmoid tumor is a rare benign tumor derived from fibrous sheath or musculoaponeurotic structure.
  • The tumor is benign histologically but considered as malignant clinically because it has high propensity on infiltrative growth with local invasion and tendency to recurrence after local excision.
  • Especially, when this tumor happens to be in the intra-abdomen, the prognosis is worse because it can cause intestinal obstruction, ureter obstruction and, fistula formation.
  • This tumor occurs more frequently in patients with familial adenomatous polyposis (FAP), in post-partume women, and at old surgical incision site.
  • We report a rare case of the young male patient who presented with an acute abdomen and underwent laparotomy and was found to have an intra-abdominal desmoid tumor with abscess formation.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Peritoneal Neoplasms / diagnosis
  • [MeSH-minor] Abdominal Abscess / diagnosis. Adult. Diagnosis, Differential. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 19458469.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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7. Satish Rao BS, Krishnanand BR, Krishan A: Androgen & vitamin D nuclear receptor expression in archival breast tumour samples. Indian J Med Res; 2006 Jan;123(1):73-82
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  • [Title] Androgen & vitamin D nuclear receptor expression in archival breast tumour samples.
  • BACKGROUND & OBJECTIVE: Breast tumour cells have receptors for androgen and vitamin D and their clinical significance is not completely understood.
  • Therefore, the present study was undertaken to analyze androgen and vitamin D receptor levels in human primary infiltrating ductal breast carcinomas (IDC) and benign breast tumour archival samples and to find out their correlation, if any, with the clinical findings.
  • METHODS: Paraffin blocks of benign and malignant breast tumours were sectioned, deparaffinized, and nuclei released by pepsin digestion.
  • RESULTS: Androgen receptor positive nuclei ranged from 16-66 per cent in the IDC tumours as compared to 36-67 per cent in the benign tumours.
  • Based on flow cytometric comparison of AR expression in AR positive and negative cell lines established earlier, 24 of 28 tumours from postmenopausal women were AR positive compared to all benign tumours and 32 of 33 tumours from pre-menopausal patients.
  • Vitamin D receptor positive nuclei ranged from 14-89 and 2-75 per cent in IDC and benign tumours, respectively.
  • All pre- or post-menopausal tumours were VDR positive as compared to 10 of 15 benign tumours that were VDR positive.
  • No correlation was seen between nuclear androgen and vitamin D receptor expression of the IDC or benign tumours.
  • No statistically significant correlation was found between nuclear receptor expression (per cent positive nuclei or antigen density) with that of tumour stage, lymph node status, tumour grade, patient age or menopausal status.
  • The expression of AR and VDR and the antigen density in the nuclei of the archival breast tumour samples were highly variable because of the tumour heterogeneity.
  • Future studies with fresh biopsy samples of tumour on AR and VDR levels and their up- or down-regulation may be useful while stratifying the patients for hormonal therapy.
  • [MeSH-major] Breast Neoplasms / chemistry. Receptors, Androgen / analysis. Receptors, Calcitriol / analysis

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  • (PMID = 16567872.001).
  • [ISSN] 0971-5916
  • [Journal-full-title] The Indian journal of medical research
  • [ISO-abbreviation] Indian J. Med. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Receptors, Androgen; 0 / Receptors, Calcitriol
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8. Sakata N, Egawa S, Motoi F, Mikami Y, Ishida M, Aoki T, Ottomo S, Fukuyama S, Rikiyama T, Katayose Y, Goto M, Unno M: Institutional indications for islet transplantation after total pancreatectomy. J Hepatobiliary Pancreat Surg; 2008;15(5):488-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Eight of the 12 patients with total pancreatectomy were operated for intraductal papillary mucinous neoplasm.
  • At our institution, the 5-year survival of patients with intraductal papillary mucinous neoplasm was far better (76.3%) than that of patients with pancreatic cancer.
  • Of the 12 patients treated with total pancreatectomy, 4 (intraductal papillary mucinous neoplasm, n = 2; islet cell tumor, n = 1; and acute pancreatitis due to arteriovenous malformation, n = 1) showed deteriorated diabetic control and therefore were considered to be candidates for islet allotransplantation according to the guidelines.
  • CONCLUSIONS: Islet allotransplantation could be indicated for patients with favorable postoperative survival who have had a total pancreatectomy for either benign or neoplastic disease.
  • [MeSH-major] Diabetes Mellitus / surgery. Islets of Langerhans Transplantation. Pancreatectomy / adverse effects. Pancreatic Neoplasms / surgery


9. Zanelli M, Cortecchia S, Righi E, Caprara L, De Lillo M, Costa F, Galanti G, Bondi A: Epithelioid angiomyolipoma of the kidney: case report. Pathologica; 2008 Jun;100(3):202-5
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  • Renal angiomyolipoma is a benign tumour histologically characterized by a mixture of adipose tissue, smooth muscle cells and thick walled blood vessels.
  • Long-believed to be a benign hamartoma, angiomyolipoma is now considered to arise from perivascular epithelioid cells.
  • Positivity for HMB45, Melan A, CD68 and CD117 are useful for diagnosis.
  • Herein, we report the clinicopathologic and immunohistochemical features of a renal tumour composed of large epithelioid mononucleated or multinucleated cells with abundant acidophilic cytoplasm and prominent nucleoli.
  • Despite the morphologic resemblance of this tumour to renal cell carcinoma, its phenotype (HMB45, Melan A and CD68 positivity and keratin negativity) parallels the phenotypic profile of angiomyolipoma.
  • [MeSH-major] Angiomyolipoma / pathology. Kidney Neoplasms / pathology

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  • (PMID = 18841830.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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10. Baratta A, Gorin RJ, Costa R: Sister Mary Joseph nodule: a case report. Cutis; 2007 Dec;80(6):469-72
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  • It is a rare occurrence but may represent the first sign of a visceral malignancy and therefore should prompt a thorough search for the primary tumor.
  • We report a case of a 66-year-old man who was referred for evaluation of an enlarging umbilical lesion.
  • After a full metastatic workup, the tumor of origin was identified as adenocarcinoma of the sigmoid colon.
  • Benign tumors of the umbilicus are uncommon.
  • This case report serves to emphasize the importance of obtaining a histologic diagnosis when any new lesion presents in the umbilical region.
  • [MeSH-major] Adenocarcinoma / secondary. Colonic Neoplasms / pathology. Skin Neoplasms / secondary. Umbilicus / pathology
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols. Combined Modality Therapy. Diagnosis, Differential. Fluorouracil. Humans. Leucovorin. Male. Organoplatinum Compounds

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  • Hazardous Substances Data Bank. FLUOROURACIL .
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  • (PMID = 18246878.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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11. Skoulakis CE, Papadakis CE, Datseris GE, Drivas EI, Kyrmizakis DE, Bizakis JG: Subcutaneous benign fibrous histiocytoma of the cheek. Case report and review of the literature. Acta Otorhinolaryngol Ital; 2007 Apr;27(2):90-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Subcutaneous benign fibrous histiocytoma of the cheek. Case report and review of the literature.
  • Fibrous histiocytoma is a benign tumour composed of a mixture of fibroblastic and histiocytic cells.
  • Based on the location of this tumour, fibrous histiocytoma are usually divided into cutaneous types and those involving deep tissues.
  • The diagnosis of fibrous histiocytoma may be clinically difficult when the lesion is located in the deep tissues, and is frequently confirmed after local excision.
  • The most important diagnostic distinction is the separation of this tumour from aggressive forms of fibrohistiocytic neoplasms, including dermatofibrosarcoma protuberans and malignant fibrous histiocytoma.
  • The lesion had been totally excised under local anaesthesia, and histopathology revealed a benign fibrous histiocytoma.
  • The diagnosis, location, treatment and prognosis of fibrous histiocytoma are also discussed.
  • [MeSH-major] Cheek / pathology. Histiocytoma, Benign Fibrous / pathology

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  • (PMID = 17608138.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 18
  • [Other-IDs] NLM/ PMC2640009
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12. Garioni E, Danesino GM, Madonia L: Pilomatricoma: Sonographic features. J Ultrasound; 2008 Jun;11(2):76-8
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  • Pilomatricomas (also known as calcifying epitheliomas of Malherbe) are benign subcutaneous tumors that arise from the cutaneous adnexa and usually affect young subjects.
  • Diagnosis is based on clinical and histological findings.

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  • [Cites] Pediatr Dermatol. 1999 Sep-Oct;16(5):341-4 [10571829.001]
  • [Cites] Dermatol Surg. 2002 Jul;28(7):603-5 [12135516.001]
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  • (PMID = 23396664.001).
  • [ISSN] 1971-3495
  • [Journal-full-title] Journal of ultrasound
  • [ISO-abbreviation] J Ultrasound
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC3553250
  • [Keywords] NOTNLM ; Color Doppler / Pilomatricoma / Ultrasonography
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13. Yavuz Balci A, Kayacioglu I, Vural U, Alkan P, Ates M, Tuygun AK, Yekeler I: Cardiac papillary fibroelastoma as a reason of transient ischemic attack for a young patient. Int J Cardiol; 2008 Jul 4;127(2):e86-8
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  • Cardiac papillary fibroelastoma is a rare primary cardiac tumor.
  • Although cardiac papillary fibroelastomas are benign tumors, they have potential life threatening complications such as sudden death, stroke, and myocardial infarction.
  • We excised the tumor completely without damage to the mitral valve.
  • We confirmed the diagnosis histopathologically.
  • Intracardiac tumors must be excised urgently due to severe complications.
  • [MeSH-major] Fibroma / complications. Heart Neoplasms / complications. Ischemic Attack, Transient / etiology. Mitral Valve / pathology. Papillary Muscles / pathology

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  • (PMID = 17706802.001).
  • [ISSN] 1874-1754
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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14. Parker WH: Etiology, symptomatology, and diagnosis of uterine myomas. Fertil Steril; 2007 Apr;87(4):725-36
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  • [Title] Etiology, symptomatology, and diagnosis of uterine myomas.
  • OBJECTIVE: To review the currently available literature regarding the biology, etiology, symptoms, and diagnosis of uterine myomas.
  • RESULT(S): Although uterine myomas presently are not well understood, many advances have been made in the understanding of the hormonal factors, genetic factors, growth factors, and molecular biology of these benign tumors.
  • CONCLUSION(S): A summary of the available literature regarding the biology, etiology, symptomatology, and diagnosis of myomas shows that, although they are still not well understood, much has been learned about uterine myomas.
  • [MeSH-major] Myoma / etiology. Uterine Neoplasms / etiology
  • [MeSH-minor] Adult. Body Weight. Estrogen Replacement Therapy / adverse effects. Estrogens / physiology. Female. Growth Substances / physiology. Humans. Incidence. Leiomyoma / diagnosis. Leiomyoma / ethnology. Leiomyoma / etiology. Leiomyoma / genetics. Middle Aged. Pregnancy. Progesterone / physiology. Risk Factors. Sarcoma / genetics. Smoking / adverse effects

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  • (PMID = 17430732.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogens; 0 / Growth Substances; 4G7DS2Q64Y / Progesterone
  • [Number-of-references] 98
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15. Jelenc F, Brencic E: Laparoscopically assisted resection of an ascending colon lipoma causing intermittent intussusception. J Laparoendosc Adv Surg Tech A; 2005 Apr;15(2):173-5
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  • Colonic lipomas are relatively uncommon clinical entity, although they are among the most common nonepithelial benign tumors of the colon.
  • We report a case of a 56-year-old man who was suffering from abdominal pain and 4 weeks of intermittent diarrhea.
  • Histology confirmed the diagnosis of benign lipoma.
  • Aspects of preoperative diagnosis and treatment are discussed, and we review the literature.
  • [MeSH-major] Colectomy / methods. Colonic Neoplasms / surgery. Intussusception / surgery. Laparoscopy. Lipoma / surgery

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  • (PMID = 15898912.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Bossert T, Gummert JF, Battellini R, Richter M, Barten M, Walther T, Falk V, Mohr FW: Surgical experience with 77 primary cardiac tumors. Interact Cardiovasc Thorac Surg; 2005 Aug;4(4):311-5
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  • [Title] Surgical experience with 77 primary cardiac tumors.
  • BACKGROUND: To assess the prognosis and to develop management strategies for primary cardiac tumors all patients were included in an ongoing study.
  • 1994 until December 2003 we prospectively evaluated all patients with cardiac tumors.
  • RESULTS: There were a total of 77 primary cardiac tumors.
  • Seventy-three were benign: myxoma (n=59), papillary fibroelastoma (n=11), lipoma (n=2), fibroma (n=1) and four malignant sarcoma (n=4).
  • Minimal invasive right thoracotomy was utilized in 19 of 73 patients all with benign tumor.
  • There were two early deaths (3%): a myxoma patient with triple vessel disease and a LVEF less than 30% and one sarcoma patient.
  • No recurrence or late death was observed in the group of benign tumors.
  • However, two remaining patients with sarcoma had recurrent disease 10 and 15 month later, respectively.
  • CONCLUSION: Surgical excision of benign cardiac tumors is a safe and curative treatment, which is feasible using minimally invasive right thoracotomy approach and provides excellent results.
  • However, therapy of malignant cardiac tumors continues to have a poor prognosis despite individualization of approach.

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  • (PMID = 17670419.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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17. Sarica FB, Cekinmez M, Tufan K, Erdoğan B, Sen O, Altinörs MN: A rare case of massive NF1 with invasion of entire spinal axis by neurofibromas: case report. Turk Neurosurg; 2008 Jan;18(1):99-106
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  • Also called 'von Recklinghausen disease' or 'peripheral neurofibromatosis', it comprises 90% of all neurofibromatosis (NF) cases.
  • It is characterized by multiple peripheral nerve sheath tumors of benign character called neurofibromas.
  • In the present paper, we discuss an NF1 case in which paraspinal neurofibromas were observed along the complete spinal axis of a 32-year-old male patient who arrived at the clinic reporting increasingly intense pins and needles and weakness.
  • We discuss the patient's diagnosis, treatment, and prognosis, and relate this case to the literature.
  • [MeSH-minor] Adult. Disease Progression. Humans. Male. Spine

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  • (PMID = 18382989.001).
  • [ISSN] 1019-5149
  • [Journal-full-title] Turkish neurosurgery
  • [ISO-abbreviation] Turk Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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18. Ozen O, Demirhan B, Altinörs N: Correlation between histological grade and MIB-1 and p53 immunoreactivity in meningiomas. Clin Neuropathol; 2005 Sep-Oct;24(5):219-24
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  • OBJECTIVE: Meningiomas for the most part are slow-growing benign tumors, but complete removal can be difficult and recurrence is an issue.
  • The aim of this study was to re-evaluate tumors diagnosed as meningioma previously in our hospital, according to the latest World Health Organization classification.
  • We also examined the relationships among parameters such as brain invasion, histological grade and Ki-67 and p53 expression in these tumors.
  • MATERIALS AND METHODS: Meningioma biopsy specimens numbering 60 (48 grade I, 11 grade II, and 1 grade III tumors) were examined immunohistochemically using monoclonal antibodies for Ki-67 (MIB-1) and p53 protein.
  • The MIB-1 labeling index (LI) for each tumor was calculated as a percentage based on the number of stained cells per total cells counted.
  • The mean MIB-1 LI values for the grade I and grade II tumors were 1.1% and 2.3%, respectively.
  • [MeSH-major] Biomarkers, Tumor / analysis. Ki-67 Antigen / biosynthesis. Meningeal Neoplasms / pathology. Meningioma / pathology. Tumor Suppressor Protein p53 / biosynthesis

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  • (PMID = 16167545.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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19. Baras A, Yu Y, Filtz M, Kim B, Moskaluk CA: Combined genomic and gene expression microarray profiling identifies ECOP as an upregulated gene in squamous cell carcinomas independent of DNA amplification. Oncogene; 2009 Aug 13;28(32):2919-24
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  • Gene expression profiling clearly separated benign squamous mucosa (BSM) from SCC and identified several candidate genes relevant to the biology of SCC.
  • When gene expression measures were correlated with amplification status at 7p11.2 locus, EGFR overexpression in relation to benign tissue was dependent on amplification and occurred in only 9% of cases.
  • [MeSH-minor] Cell Line, Tumor. Cell Survival. Gene Amplification. Gene Expression Regulation, Neoplastic. Genetic Predisposition to Disease. HeLa Cells. Humans. Immunoblotting. RNA, Small Interfering / genetics. Reverse Transcriptase Polymerase Chain Reaction. Time Factors. Transfection. Up-Regulation


20. Martinez S, Heyneman LE, McAdams HP, Rossi SE, Restrepo CS, Eraso A: Mucoid impactions: finger-in-glove sign and other CT and radiographic features. Radiographics; 2008 Sep-Oct;28(5):1369-82
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  • The sign also may be observed in many acquired conditions, include inflammatory and infectious diseases (allergic bronchopulmonary aspergillosis, broncholithiasis, and foreign body aspiration), benign neoplastic processes (bronchial hamartoma, lipoma, and papillomatosis), and malignancies (bronchogenic carcinoma, carcinoid tumor, and metastases).
  • To point to the correct diagnosis, the radiologist must be familiar with the key radiographic and CT features that enable differentiation among the various likely causes.
  • CT is more useful than chest radiography for differentiating between mucoid impaction and other disease processes, such as arteriovenous malformation, and for directing further diagnostic evaluation.
  • [MeSH-major] Bronchial Diseases / complications. Bronchial Diseases / diagnosis. Mucus / radiography. Radiography, Thoracic / methods. Tomography, X-Ray Computed / methods

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  • [Copyright] (c) RSNA, 2008.
  • (PMID = 18794313.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 45
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21. Kataoka K, Nishikawa T, Fujiwara T, Matsuura M: [Leiomyoma of the trachea; report of a case]. Kyobu Geka; 2010 Apr;63(4):336-9
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  • [Title] [Leiomyoma of the trachea; report of a case].
  • Leiomyoma of the trachea is a rare benign tumor.
  • Chest X-ray and computed tomography (CT) scan demonstrated a tracheal tumor.
  • Bronchofiberscopy revealed a polypoid round tumor in the trachea.
  • The tumor originated from the membranous portion of the trachea without narrow stalk.
  • Definitive diagnosis of tracheal leiomyoma was made by histological examination.
  • [MeSH-major] Leiomyoma / surgery. Tracheal Neoplasms / surgery

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  • (PMID = 20387511.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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22. Filipovski V, Banev S, Janevska V, Dukova B: Granular cell tumor of the breast: a case report and review of literature. Cases J; 2009;2:8551
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  • [Title] Granular cell tumor of the breast: a case report and review of literature.
  • A 22-year-old female patient presented with a breast mass lesion with a clinical suspicion of a fibroadenoma.
  • Histological evaluation revealed a rare benign neoplasm - granular cell tumor.Granular cell tumor is rare neoplasm that may arise in virtually any body site, and in 5% it occurs in the breast.
  • The histogenesis of this tumor is still rather controversial and currently the most acceptable theory is a Schwann cell origin.
  • The main histological feature is granular cytoplasm of the tumor cells.From a clinical point of view there is a similarity between granular cell tumor and mammary carcinoma on mammography and ultrasound.
  • Pathohistologically, sometimes, differential diagnostic difficulties exist concerning apocrine carcinoma, histiocytic lesions and metastatic neoplasms.

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  • [Cites] Arch Pathol Lab Med. 1992 Feb;116(2):206-8 [1733419.001]
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  • (PMID = 19918386.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2769456
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23. Alobaid AS: Mucinous cystadenoma of the ovary in a 12-year-old girl. Saudi Med J; 2008 Jan;29(1):126-8
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  • Benign mucinous cystadenomas MCA are rare benign neoplasms in the pediatric age group.
  • The final pathology revealed a benign MCA.
  • Patients with mucinous tumors usually present late, this may lead to renal insufficiency secondary to urinary outflow obstruction.
  • The diagnosis of MCA should be considered in children who present with huge pelvi-abdominal masses.
  • [MeSH-major] Cystadenoma, Mucinous / diagnosis. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Humans

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  • (PMID = 18176687.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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24. Pipinikas CP, Carter ND, Corbishley CM, Fenske CD: HIF-1alpha mRNA gene expression levels in improved diagnosis of early stages of prostate cancer. Biomarkers; 2008 Nov;13(7):680-91
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  • [Title] HIF-1alpha mRNA gene expression levels in improved diagnosis of early stages of prostate cancer.
  • OBJECTIVES: Several clinical studies have indicated that the rates of invasive growth and metastatic disease in cancer depend on the degree of hypoxia, which is mediated by hypoxia-inducible factor 1 alpha (HIF-1alpha).
  • To determine its potential role as a marker for prostate cancer (CaP) diagnosis, HIF-1alpha mRNA levels were measured in blood samples of patients diagnosed with different stages of prostatic disease.
  • Quantitative data were compared with serum prostate-specific antigen (PSA) measurements to determine variations in the accuracy of the CaP diagnosis.
  • RESULTS: HIF-1alpha mRNA levels were significantly upregulated in patients with localized CaP (LocCaP; n=63; p<0.0001), compared with patients with no evidence of malignancy (NEOM) and benign prostatic hyperplasia (BPH) (n=35 for both patient groups combined).
  • Receiver operator characteristic (ROC) curve analysis demonstrated that HIF-1alpha specificity for the NEOM/BPH diagnosis was 88.6%.
  • Specificity of the NEOM diagnosis at PSA levels of 4.0 ng ml(-1) was 28.6% and sensitivity of the LocCap diagnosis was 65.1%, demonstrating a reduced overall diagnostic efficiency, compared with that given by HIF-1alpha measurements, of 52.0%.
  • Levels of HIF-1alpha in patients with metastatic CaP (MetCaP; n=27)) were similar to those in the NEOM/BPH group.
  • This study demonstrates increased accuracy of early-stage disease diagnosis using HIF-1alpha qRT-PCR compared with serum PSA measurements.
  • [MeSH-major] Early Detection of Cancer. Hypoxia-Inducible Factor 1, alpha Subunit / genetics. Prostatic Neoplasms / diagnosis. RNA, Neoplasm / blood
  • [MeSH-minor] Biomarkers, Tumor. Disease Progression. Gene Expression Regulation, Neoplastic. Humans. Male. Neoplasm Metastasis. Prostate-Specific Antigen / blood. RNA, Messenger / blood. ROC Curve. Reverse Transcriptase Polymerase Chain Reaction. Sensitivity and Specificity. Time Factors

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  • (PMID = 19096962.001).
  • [ISSN] 1366-5804
  • [Journal-full-title] Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
  • [ISO-abbreviation] Biomarkers
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / RNA, Messenger; 0 / RNA, Neoplasm; EC 3.4.21.77 / Prostate-Specific Antigen
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25. Mischiati C, Natali PG, Sereni A, Sibilio L, Giorda E, Cappellacci S, Nicotra MR, Mariani G, Di Filippo F, Catricalà C, Gambari R, Grammatico P, Giacomini P: cDNA-array profiling of melanomas and paired melanocyte cultures. J Cell Physiol; 2006 Jun;207(3):697-705
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  • Array results were validated by RT-PCR on a small panel of surgically removed nevocellular nevi and metastatic melanoma lesions, and by immunohistochemistry on a large panel of benign and malignant lesions of the nevomelanocytic lineage.
  • These data provide the proof of principle that cDNA profiling of paired melanocyte/melanoma cultures sorts out novel, early signatures of melanocyte transformation that could contribute to the clinical management of patients at high risk of metastatic disease.
  • [MeSH-major] Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Melanocytes / cytology. Melanocytes / metabolism. Melanoma / genetics. Melanoma / pathology. Oligonucleotide Array Sequence Analysis
  • [MeSH-minor] Antigens, CD / metabolism. Antigens, CD9. Cell Lineage. Cells, Cultured. Collagen Type IV / metabolism. Down-Regulation / genetics. Humans. Immunohistochemistry. Membrane Glycoproteins / metabolism. Neoplasm Staging. RNA, Messenger / genetics. STAT2 Transcription Factor / metabolism. Up-Regulation / genetics

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16523488.001).
  • [ISSN] 0021-9541
  • [Journal-full-title] Journal of cellular physiology
  • [ISO-abbreviation] J. Cell. Physiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD9; 0 / CD9 protein, human; 0 / Collagen Type IV; 0 / Membrane Glycoproteins; 0 / RNA, Messenger; 0 / STAT2 Transcription Factor; 0 / STAT2 protein, human
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26. Zhang T, Zhang XM, Zhang XM, Li QL: [Intravenous leiomyomatosis with intracardiac extension: a case report]. Beijing Da Xue Xue Bao; 2008 Dec 18;40(6):642-4
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  • Intravenous leiomyomatosis is characterized by a proliferation of benign smooth muscular tissue growing into uterine with malignant appearance.
  • On extremely rare occasions, the tumor may grow out of the pelvis and extend into the inferior vena cava and the right atrium.
  • Pelvic vascular ultrasound revealed the thrombotic material in the inferior vena cava and the left common iliac vein, and confirmed the presence of a complex mass in the left annex region.
  • Based on the findings, the initial diagnosis was intracardiac and intravenous tumor.
  • An operation was performed through a sternotomy and laparotomy to remove the whole tumor from the left common iliac vein to the right atrium, ligate left internal iliac vein mean-wile.
  • Immunohistochemical studies revealed that the tumor cells were fusiform shape, there was no karyokinesis and necrosis, and the tumor cells were positive for smooth muscle antigen and desmin, as well as estrogen receptor and progesterone receptor.
  • The differential diagnosis of the disease compared with primary cardiovascular sarcomas and thrombus was difficult.
  • The final diagnosis relied on immunohistochemical analysis, however, the short-term result of operation was acceptable.
  • [MeSH-major] Heart Neoplasms / secondary. Leiomyomatosis / pathology. Vascular Neoplasms / pathology. Vena Cava, Inferior / pathology
  • [MeSH-minor] Adult. Female. Humans. Neoplastic Cells, Circulating / pathology. Uterine Neoplasms / pathology

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  • (PMID = 19088839.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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27. Santini M, Fiorello A, Mansi L, Rambaldi PF, Vicidomini G, Busiello L, Messina G, Nargi P: The role of technetium-99m hexakis-2-methoxyisobutyl isonitrile in the detection of neoplastic lung lesions. Eur J Cardiothorac Surg; 2009 Feb;35(2):325-31
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  • [Title] The role of technetium-99m hexakis-2-methoxyisobutyl isonitrile in the detection of neoplastic lung lesions.
  • OBJECTIVE: Our goal was to determine the role of technetium-99m hexakis-2-methoxyisobutyl isonitrile ((99m)Tc-MIBI) in the detection of neoplastic lung lesions.
  • In addition, semiquantitative analysis was made by calculating tumor/contralateral normal lung ratio (T/N).
  • Finally, the scintigraphic findings were correlated to the histopathological diagnosis obtained by invasive procedure or confirmation of instrumental exams.
  • Nineteen patients had a benign disease.
  • The mean size+/-standard deviation of benign nodules was 3.3+/-1.71 cm (range 2-6 cm). (99m)Tc-MIBI SPECT delineated focal lesions with an increase in tracer accumulation in 55/60 malignant lesions; in 5/60 malignant lesions was negative.
  • In patients with neoplastic lesion, the mean T/N ratio value+/-standard deviation was 1.72+/-0.35 whereas in patients with benign lesions was 1.14+/-0.25.
  • [MeSH-major] Lung Neoplasms / radionuclide imaging. Radiopharmaceuticals. Technetium Tc 99m Sestamibi
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Epidemiologic Methods. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Tomography, Emission-Computed, Single-Photon / methods. Tomography, X-Ray Computed

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  • (PMID = 18996706.001).
  • [ISSN] 1873-734X
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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28. Parsi MA, Li A, Li CP, Goggins M: DNA methylation alterations in endoscopic retrograde cholangiopancreatography brush samples of patients with suspected pancreaticobiliary disease. Clin Gastroenterol Hepatol; 2008 Nov;6(11):1270-8
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  • [Title] DNA methylation alterations in endoscopic retrograde cholangiopancreatography brush samples of patients with suspected pancreaticobiliary disease.
  • BACKGROUND & AIMS: Molecular markers of pancreatic neoplasia could aid in the evaluation of suspicious pancreatic lesions where cytology is nondiagnostic.
  • METHODS: Methylation analysis was performed on endoscopically obtained brush samples from the biliary and pancreatic ducts from 130 individuals with biliary tract strictures: 41 with pancreatic ductal adenocarcinoma, 10 with biliary tract cancers, 13 with other periampullary neoplasms, and 66 with non-neoplastic strictures including 27 with primary sclerosing cholangitis and 39 with other benign strictures.
  • RESULTS: QMSP could accurately distinguish patients with pancreatic cancer and other periampullary cancers from those with benign periampullary disease; 73.2% of patients with pancreatic ductal adenocarcinoma had at least 1 gene positive for methylation by QMSP (defined as > or =1% TFPI-2 DNA and > or =3% methylated NPTX2 and Cyclin D2 DNA) in their brush samples, compared with 80% of patients with a biliary tract cancer and only 13.6% of patients with a benign stricture (P < .001).
  • CONCLUSIONS: The detection and quantification of aberrantly methylated DNA in endoscopic brush samples are a promising tool to differentiate benign from malignant biliary strictures.

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  • (PMID = 18995218.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA062924; United States / NCI NIH HHS / CA / R01 CA120432; United States / NCI NIH HHS / CA / CA62924; United States / NCI NIH HHS / CA / CA062924-130008; United States / NCI NIH HHS / CA / R01 CA120432-03; United States / NCI NIH HHS / CA / CA120432-03; United States / NCI NIH HHS / CA / P50 CA062924-130008
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CCND2 protein, human; 0 / Cyclin D2; 0 / Cyclins; 0 / Glycoproteins; 0 / Nerve Tissue Proteins; 0 / neuronal pentraxin; 0 / tissue-factor-pathway inhibitor 2; 9007-41-4 / C-Reactive Protein
  • [Other-IDs] NLM/ NIHMS85843; NLM/ PMC2636968
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29. Ramnath N, Menezes RJ, Loewen G, Dua P, Eid F, Alkhaddo J, Paganelli G, Natarajan N, Reid ME: Hormone replacement therapy as a risk factor for non-small cell lung cancer: results of a case-control study. Oncology; 2007;73(5-6):305-10
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  • [Title] Hormone replacement therapy as a risk factor for non-small cell lung cancer: results of a case-control study.
  • Controls included 1,195 women, randomly selected from a pool of 5,845 eligible individuals, who received medical services at RPCI for non-neoplastic conditions; they had come to RPCI with a suspicion of neoplastic disease, but were diagnosed with neither benign nor malignant conditions.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / chemically induced. Estrogen Replacement Therapy / adverse effects. Lung Neoplasms / chemically induced


30. Jordan KW, Nordenstam J, Lauwers GY, Rothenberger DA, Alavi K, Garwood M, Cheng LL: Metabolomic characterization of human rectal adenocarcinoma with intact tissue magnetic resonance spectroscopy. Dis Colon Rectum; 2009 Mar;52(3):520-5
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  • Multiple biopsies of macroscopically malignant rectal tumors and benign rectal mucosa were obtained from each patient for a total of 14 malignant and 9 benign samples.
  • RESULTS: Metabolomic profiles represented by principle components of metabolites measured from spectra differentiated between malignant and benign samples and correlated with the volume percent of cancer (P = 0.0065 and P = 0.02, respectively) and benign epithelium (P = 0.0051 and P = 0.0255, respectively), and with volume percent of stroma, and inflammation.
  • Future studies should determine its utility in in vivo applications for non-invasive pathologic evaluations of suspicious rectal lesions.

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  • (PMID = 19333056.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA115746-03; United States / NCI NIH HHS / CA / R01 CA095624; United States / NCI NIH HHS / CA / CA095624; United States / NCI NIH HHS / CA / CA115746; United States / NCI NIH HHS / CA / CA095624-04; United States / NCI NIH HHS / CA / R01 CA115746; United States / NCI NIH HHS / CA / R01 CA095624-04; United States / NCI NIH HHS / CA / R01 CA115746-03
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS119443; NLM/ PMC2720561
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31. Zhang S, Zhou X, Yu H, Yu Y: Expression of tumor-specific antigen MAGE, GAGE and BAGE in ovarian cancer tissues and cell lines. BMC Cancer; 2010;10:163
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  • [Title] Expression of tumor-specific antigen MAGE, GAGE and BAGE in ovarian cancer tissues and cell lines.
  • BACKGROUND: To observe mRNA expression of tumor-specific antigen MAGE, BAGE and GAGE in epithelial ovarian cancer tissues and cell lines, to explore the relationship between gene expression and diagnosis, treatment and prognosis of ovarian cancer, and to evaluate the feasibility of their gene products as markers, and an immunotherapy target for ovarian cancer.
  • METHODS: mRNA expression of MAGE-1, MAGE-3, GAGE-1/2 and BAGE were determined by reverse transcription polymerase chain reaction (RT-PCR) in 14 cases of normal ovarian tissue, 20 cases of ovarian benign tumor specimens, 41 cases of ovarian cancer specimens, and ovarian cancer cell lines SKOV3, A2780, and COC1.
  • In benign tumors, only the MAGE gene was expressed; the expression rate of this gene in benign tumors was 15% (3/20).
  • Positive expression of MAGE-1 and MAGE-3 was positively correlated with tumor differentiation and the clinical stage of the ovarian cancer.
  • CONCLUSION: Tumor-specific antigen MAGE, BAGE and GAGE may play a role in the occurrence and development of ovarian cancer.
  • These genes can be used as one of the important indicators for early diagnosis, efficacy evaluation and prognostic determination of ovarian cancer.
  • [MeSH-major] Antigens, Neoplasm / genetics. Biomarkers, Tumor / genetics. Cystadenocarcinoma, Serous / genetics. Neoplasm Proteins / genetics. Ovarian Neoplasms / genetics
  • [MeSH-minor] Cell Line, Tumor. Feasibility Studies. Female. Gene Expression Regulation, Neoplastic. Humans. Melanoma-Specific Antigens. Neoplasm Staging. Prognosis. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 20423514.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / BAGE protein, human; 0 / Biomarkers, Tumor; 0 / GAGE1 protein, human; 0 / GAGE2A protein, human; 0 / MAGEA1 protein, human; 0 / MAGEA3 protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / RNA, Messenger
  • [Other-IDs] NLM/ PMC2868811
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32. Chen CM, Chen KH, Jung SM, Hsu HC, Wang CM: Central neurocytoma: 9 case series and review. Surg Neurol; 2008 Aug;70(2):204-9
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  • Whether the high score of functional outcome was correlated with benign tumor course or 5-year survival rate remains uncertain.
  • We recommend regular follow-up for detecting tumor growth or recurrence, although central neurocytomas are always benign.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / therapy. Neurocytoma / diagnosis. Neurocytoma / therapy
  • [MeSH-minor] Activities of Daily Living. Adult. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Cerebral Angiography. Female. Follow-Up Studies. Glial Fibrillary Acidic Protein / analysis. Glial Fibrillary Acidic Protein / metabolism. Humans. Ki-67 Antigen / analysis. Ki-67 Antigen / metabolism. Magnetic Resonance Imaging. Male. Neurosurgical Procedures / methods. Radiotherapy / methods. Survival Rate. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18262625.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; 0 / Ki-67 Antigen
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33. Illian C, Kortmann HR, Künstler HO, Poll LW, Schofer M: Tenosynovial giant cell tumors as accidental findings after episodes of distortion of the ankle: two case reports. J Med Case Rep; 2009;3:9331
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  • [Title] Tenosynovial giant cell tumors as accidental findings after episodes of distortion of the ankle: two case reports.
  • INTRODUCTION: Tenosynovial giant cell tumors are benign tumors of uncertain pathogenesis.
  • Due to a high recurrence rate of up to 50%, some authors call a giant cell tumor a semimalignant tumor.
  • To date, less than 10 cases of tenosynovial giant cell tumor of the ankle have been published in the international medical literature.
  • CASE PRESENTATION: In this case report, we present two patients with localized tumors that were detected accidentally after the occurrence of ankle sprains with persisting pain in the joint.
  • The tumors were resected by open marginal surgery and regular follow-up examinations were carried out.
  • CONCLUSIONS: We present an unusual occurrence of a tumor along with a possible follow-up strategy, which has not been previously discussed in the international literature.

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  • (PMID = 20062758.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803852
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34. Chemli H, Dhouib M, Karray F, Abdelmoula M: [Risk factors for recurrence of maxillary odontogenic keratocysts]. Rev Stomatol Chir Maxillofac; 2010 Sep;111(4):189-92
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  • [Transliterated title] Les facteurs de risque de récidive des kératokystes odontogéniques des maxillaires.
  • PURPOSE: The odontogenic keratocyst is a benign tumor with a high recurrence rate and aggressive behavior.
  • The mandible was the most common site (30 cases).
  • [MeSH-minor] Adolescent. Adult. Age Factors. Child. Chin / innervation. Dental Fistula / diagnosis. Female. Follow-Up Studies. Humans. Lip / innervation. Male. Middle Aged. Osteolysis / radiography. Paresthesia / diagnosis. Prognosis. Recurrence. Retrospective Studies. Risk Factors. Root Resorption / radiography. Sex Factors. Tomography, X-Ray Computed. Young Adult

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20553889.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
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35. Kusumi T, Minakawa M, Fukui K, Saito S, Ohashi M, Sato F, Fukuda I, Kijima H: Cardiac tumor comprising two components including typical myxoma and atypical hypercellularity suggesting a malignant change. Cardiovasc Pathol; 2009 Nov-Dec;18(6):369-74
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  • [Title] Cardiac tumor comprising two components including typical myxoma and atypical hypercellularity suggesting a malignant change.
  • BACKGROUND: Cardiac myxoma is a benign neoplasm and is not considered to carry a risk of malignant transformation.
  • We describe a case of a cardiac tumor comprising typical myxoma and atypical cellular parts.
  • METHODS AND RESULTS: A 72-year-old woman was found to have a tumor in the left atrial chamber after undergoing echocardiographic investigation and so she underwent tumor excision surgery.
  • The excised tumor was composed of two components with different features with a smooth transition from one type to the other.
  • The apex of the tumor showed a gelatinous and villous appearance on gross examination, and histological examination revealed that the tumor cells had small oval nuclei and eosinophilic cytoplasm and were arranged in cords and vasoformative structures in the myxoid matrix.
  • The base of the tumor appeared as a solid mass on gross examination with hypercellular proliferation of spindle-shaped tumor cells and intersecting fascicles observed histologically.
  • On immunohistochemistry, the tumor cells were found to be positive for alpha-smooth muscle actin, calretinin, and CD34, and this immunoreactivity was decreased at the tip.
  • CONCLUSIONS: We diagnosed this tumor as cardiac myxoma with an atypical hypercellular component suggesting a malignant change.
  • [MeSH-major] Heart Neoplasms / pathology. Myxoma / pathology

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  • (PMID = 18619858.001).
  • [ISSN] 1879-1336
  • [Journal-full-title] Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
  • [ISO-abbreviation] Cardiovasc. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. Langner E, Del Negro A, Akashi HK, Araújo PP, Tincani AJ, Martins AS: Schwannomas in the head and neck: retrospective analysis of 21 patients and review of the literature. Sao Paulo Med J; 2007 Jul 5;125(4):220-2
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  • CONTEXT AND OBJECTIVE: Schwannomas are benign neoplasms of the peripheral nerves originating in the Schwann cells.
  • They occur in the head and neck region in only 25% of the cases, and may be associated with Von Recklinghausen's disease.
  • The present study retrospectively analyzed some data on this disease in the head and neck region and reviewed the literature on the subject.
  • DESIGN AND SETTING: Retrospective study at Head and Neck Service, Universidade Estadual de Campinas.
  • Four patients had a positive past history of type I neurofibromatosis or Von Recklinghausen's disease.
  • Tumor enucleation was performed in 16 patients; the other five required more extensive surgery.
  • They are solitary lesions, except in Von Recklinghausen's disease.
  • They are generally benign, and rarely recur.
  • The recommended surgical treatment is tumor enucleation.
  • [MeSH-major] Head and Neck Neoplasms. Neurilemmoma

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  • (PMID = 17992392.001).
  • [ISSN] 1516-3180
  • [Journal-full-title] São Paulo medical journal = Revista paulista de medicina
  • [ISO-abbreviation] Sao Paulo Med J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 16
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37. Czeczot H, Scibior-Bentkowska D, Skrzycki M, Majewska M, Podsiad M: [Lipid peroxidation level in gastrointestinal tract tumors]. Pol Merkur Lekarski; 2010 Nov;29(173):309-14
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  • [Title] [Lipid peroxidation level in gastrointestinal tract tumors].
  • Oxygen free radicals and their reactive derivatives participate in formation of chronic inflammation states, which facilitate development of gastrointestinal tract tumors.
  • The aim of the study was the determination of lipid peroxidation level in gastrointestinal tract tumors (stomach, liver, colon, and colorectal cancer to liver metastases).
  • MATERIAL AND METHODS: Materials for studies were obtained from 150 patients with gastrointestinal tract tumors: 10 with stomach cancer, 30 with malignant and benign liver cancers, 60 with primary colorectal cancer, and 50 with metachronous colorectal cancer liver metastases.
  • Tumor specimens, and normal adjacent tissues (6-7 cm from the edge of the tumor), which served as control tissue in studies, were collected from patients (with their consent) during surgery.
  • RESULTS: The study showed the highest concentration of TBARS in benign, and the lowest in malignant liver tumors.
  • Other types of gastrointestinal tumors studied, were characterized by similar levels of lipid peroxidation.
  • TBARS concentration in these tumors was approximately 2-fold higher than in malignant liver tumors and much lower than in benign tumors.
  • In all cancers of the digestive tract with the exception of malignant liver tumors increased level of TBARS was found, comparing with control tissue.
  • The level of lipid peroxidation in liver cirrhosis and malignant liver tumors was similar.
  • There were no significant differences in TBARS concentration in the tumors of particular sections of the intestine and normal colon.
  • The changes of lipid peroxidation level--a marker of oxidative stress in gastrointestinal tumors appear to be closely associated with their development stages (liver cirrhosis/malignant liver cancer; colorectal cancer/colorectal cancer liver metastases) and are likely to create such conditions, in which cancerous cells may proliferate, undergo gradual dedifferentiation and malignancy, and generate metastases.
  • [MeSH-major] Gastrointestinal Neoplasms / metabolism. Lipid Peroxidation. Liver Neoplasms / secondary

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  • (PMID = 21268915.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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38. De Flora S, Izzotti A: Mutagenesis and cardiovascular diseases Molecular mechanisms, risk factors, and protective factors. Mutat Res; 2007 Aug 1;621(1-2):5-17
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  • A variety of experimental and epidemiological findings are also in favor of the somatic mutation theory, which maintains that the earliest event in the atherogenic process is represented by mutations in arterial smooth muscle cells, akin to formation of a benign tumor.
  • [MeSH-minor] Animals. Atherosclerosis / epidemiology. Atherosclerosis / etiology. Atherosclerosis / genetics. Atherosclerosis / prevention & control. DNA Adducts / metabolism. Humans. Neoplasms / epidemiology. Neoplasms / etiology. Neoplasms / genetics. Neoplasms / prevention & control. Polymorphism, Genetic. Risk Factors

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  • (PMID = 17383689.001).
  • [ISSN] 0027-5107
  • [Journal-full-title] Mutation research
  • [ISO-abbreviation] Mutat. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA Adducts
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39. Villalón G, Monteagudo C, Martín JM, Ramón D, Alonso V, Jordá E: [Chondroid syringoma: a clinical and histological review of eight cases]. Actas Dermosifiliogr; 2006 Nov;97(9):573-7
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  • [Transliterated title] Siringoma condroide: revisión clínica e histológica de ocho casos.
  • INTRODUCTION: Chondroid syringoma is a rare skin tumor that presents as a slow growing, indolent lesion, that is more frequent in male adults and is usually benign.
  • It is treated surgically and its diagnosis is histological.
  • RESULTS: Most of the cases occurred as well-defined nodular lesions, whose presumptive clinical diagnosis was adnexal or cystic pathology.
  • DISCUSSION: The chondroid syringoma is usually a small-sized skin tumor, frequently on the head and neck.
  • The final treatment of these tumors is surgical.
  • As a general rule, it is a benign tumor.
  • Some authors have proposed the term of atypical mixed tumor of the skin for those chondroid syringomas with histological traits of malignancy but without evidence of metastasis.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17173760.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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40. Eley KA, Watt-Smith PA, Watt-Smith SR: Deformity of the tongue in an infant: Riga-Fede disease. Paediatr Child Health; 2010 Nov;15(9):581-2
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  • [Title] Deformity of the tongue in an infant: Riga-Fede disease.
  • Riga-Fede is the rare condition of benign ulceration caused by repetitive trauma to the lingual tissues by the teeth in children younger than two years of age.
  • The differential diagnosis includes infective and neoplastic conditions.
  • Histological diagnosis is required when the symptoms fail to resolve with standard management.
  • Riga-Fede disease should be considered in infants presenting with oral ulceration.

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  • (PMID = 22043140.001).
  • [ISSN] 1918-1485
  • [Journal-full-title] Paediatrics & child health
  • [ISO-abbreviation] Paediatr Child Health
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC3009564
  • [Keywords] NOTNLM ; Child / Riga-Fede / Tongue / Tooth
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41. Ruttenstock EM, Saxena AK, Schwinger W, Sorantin E, Hoellwarth ME: Pediatric ovarian tumors--dilemmas in diagnosis and management. Eur J Pediatr Surg; 2010 Mar;20(2):116-20
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  • [Title] Pediatric ovarian tumors--dilemmas in diagnosis and management.
  • BACKGROUND: Ovarian tumors are rare in the pediatric age group and thus diagnostic and treatment strategies are heterogeneous.
  • This study aims to evaluate ovarian tumors with a focus on age at presentation, imaging characteristics, diagnostic strategy, tumor presentation and management.
  • METHODS: Data was collected retrospectively from patients admitted between 1991 and 2008 for the evaluation and therapy of ovarian tumors.
  • RESULTS: Twenty-five patients were identified with neoplastic ovarian lesions (mean age 10.7 years).
  • Sixteen patients (64%) underwent surgery for benign and 9 (36%) for malignant tumors.
  • Benign tumors (n=16) had a mean diameter of 10.7 cm and mean age at presentation was 9.6 years compared to a diameter of 18.6 cm and 12.3 years in the malignant group (n=9).
  • Elevated tumor markers were observed in 3 (12.5%) benign tumors and in 7 (77.8%) malignant tumors.
  • In preoperative ultrasound investigation, cyst formation was identified in 4 benign tumors and solid tumor mass in 2 malignant tumors.
  • CONCLUSION: Cyst formation, small tumor size and younger age at presentation were characteristic of benign tumors.
  • Malignant tumors often presented with elevated tumor markers, a larger size and a solid consistency.
  • Diagnostic dilemmas remain for both tumor groups due to the different tumor types and the heterogeneity of presentation.
  • [MeSH-major] Ovarian Neoplasms / pathology. Ovarian Neoplasms / surgery
  • [MeSH-minor] Child. Female. Humans. Neoplasm Staging. Retrospective Studies

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  • (PMID = 20112185.001).
  • [ISSN] 1439-359X
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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42. Garman M, Metry D: Vulvar syringomas in a 9-year-old child with review of the literature. Pediatr Dermatol; 2006 Jul-Aug;23(4):369-72
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  • Syringomas are benign tumors of the eccrine sweat gland that are most common to the periorbital location.
  • We report a 9-year-old girl who had severe pruritus secondary to syringomas of the vaginal labia, and review the literature on this unusual disorder.
  • [MeSH-major] Sweat Gland Neoplasms / pathology. Sweat Gland Neoplasms / surgery. Syringoma / pathology
  • [MeSH-minor] Child. Female. Humans. Treatment Outcome. Vulvar Neoplasms

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  • (PMID = 16918636.001).
  • [ISSN] 0736-8046
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Byrne HM, Alarcon T, Owen MR, Webb SD, Maini PK: Modelling aspects of cancer dynamics: a review. Philos Trans A Math Phys Eng Sci; 2006 Jun 15;364(1843):1563-78
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  • Cancer is a complex disease in which a variety of factors interact over a wide range of spatial and temporal scales with huge datasets relating to the different scales available.
  • In this paper, we explain why mathematics is a powerful tool for interpreting such data by presenting case studies that illustrate the types of insight that realistic theoretical models of solid tumour growth may yield.
  • These range from discriminating between competing hypotheses for the formation of collagenous capsules associated with benign tumours to predicting the most likely stimulus for protease production in early breast cancer.
  • [MeSH-major] Models, Biological. Neoplasms / blood supply. Neoplasms / physiopathology. Neovascularization, Pathologic / physiopathology. Spheroids, Cellular / physiology. Tumor Cells, Cultured / physiology

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  • (PMID = 16766361.001).
  • [ISSN] 1364-503X
  • [Journal-full-title] Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
  • [ISO-abbreviation] Philos Trans A Math Phys Eng Sci
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / / E18413/2
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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44. Feng Y, Yang ZG, Chen T, Wang Q, Deng W: Giant plexiform neurofibroma with hemorrhage in cranio-maxillofacial region as depicted on CT and MRI. Eur J Med Res; 2010 Feb 26;15(2):84-7
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  • Plexiform neurofibroma (PN) is a rare benign tumor and a special subtype of neurofibromatosis type 1 (NF1).
  • [MeSH-major] Hemorrhage / diagnosis. Maxillary Neoplasms / diagnosis. Neurofibroma, Plexiform / diagnosis

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  • [Cites] Am J Med Genet. 2000 May 15;92(2):132-5 [10797438.001]
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  • (PMID = 20452890.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC3352051
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45. Garrido-Ruiz MC, Ramos P, Enguita AB, Rodriguez Peralto JL: Subcutaneous atypical fibrous histiocytoma. Am J Dermatopathol; 2009 Jul;31(5):499-501
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  • Benign fibrous histiocytoma is one of the most frequent benign neoplasms mainly composed of a mixture of fibroblastic and histiocytic cells, especially found in the skin (dermatofibroma), particularly in the limbs.
  • The diagnosis of cutaneous benign fibrous histiocytoma is generally easy; however, rare variants may be difficult to identify, and the diagnosis only confirmed after exhaustive histopathological examination.
  • We report a case of a 38-year-old woman with a painless swelling on the abdominal wall, which was totally excised and histopathologically diagnosed as subcutaneous atypical fibrous histiocytoma.
  • Prominent hyaline collagen bundles surrounded by tumor cells were observed, predominantly at the periphery of the lesion.
  • Definitive diagnosis, although especially difficult in our case, is established by characteristic histological and immunohistochemical criteria.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry

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  • (PMID = 19542931.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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46. Dalpa E, Gourvas V, Baritaki S, Miyakis S, Samaras V, Barbatis C, Sourvinos G, Spandidos DA: High prevalence of Human Herpes Virus 8 (HHV-8) in patients with Warthin's tumors of the salivary gland. J Clin Virol; 2008 Jun;42(2):182-5
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  • [Title] High prevalence of Human Herpes Virus 8 (HHV-8) in patients with Warthin's tumors of the salivary gland.
  • BACKGROUND: Warthin's tumor is a common benign neoplasm of the salivary gland.
  • Human Herpes Virus 8 (HHV-8) is the etiologic agent for all forms of Kaposi's sarcoma (KS), and HHV-8 DNA is present in saliva, suggesting that non-sexual transmission is associated with latent infection of the salivary gland.
  • OBJECTIVES: To provide insights into the HHV-8 cell tropism, the presence of HHV-8 was investigated in a series of Warthin's tumors of the salivary gland and corresponding adjacent normal tissue.
  • STUDY DESIGN: Forty-three patients with Warthin's tumors (cystadenolymphoma) were tested for the presence of HHV-8 DNA, and corresponding adjacent normal tissue samples were obtained from 15 patients.
  • RESULTS: HHV-8 DNA was detected in 19 out of 43 (44%) salivary gland tumor samples.
  • Among the 15 cases with paired samples, 9 were HHV-8-positive for both samples, 4 were HHV-8-negative for both samples while in two cases HHV-8 was detected only in the tumor specimens.
  • CONCLUSIONS: HHV-8 is frequently detected in adenoid salivary neoplasms, suggesting a significant role of the virus in the etiopathogenesis of the disease.
  • Larger studies are required to investigate the role of HHV-8 in the development or progression of Warthin's tumors.
  • [MeSH-major] Adenolymphoma / virology. Herpesvirus 8, Human / isolation & purification. Salivary Gland Neoplasms / virology. Salivary Glands / virology

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  • (PMID = 18339579.001).
  • [ISSN] 1386-6532
  • [Journal-full-title] Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • [ISO-abbreviation] J. Clin. Virol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Viral
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47. Habibi Z, Nejat F, Naeini PE, Mahjoub F: Teratoma inside a myelomeningocele. J Neurosurg; 2007 Jun;106(6 Suppl):467-71
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  • The coincidence of an MMC and a neoplasm is rare, and only limited reports on the concurrence of a teratoma within an MMC have been published.
  • The postoperative histopathological assessments in 15 (4.5%) of these patients revealed evidence of a teratoma inside the MMC.
  • CONCLUSIONS: The special feature of a protruding fingerlike appendage or intraoperative detection of a cystic portion of an MMC without direct connection to the spinal canal can be possible signs of teratoma concurrent with an MMC.
  • Teratoma inside an MMC is a benign neoplasm, without any recurrence after standard surgery for an MMC.
  • [MeSH-major] Central Nervous System Neoplasms / complications. Meningomyelocele / complications. Teratoma / complications

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  • (PMID = 17566404.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Schlosser RJ, Woodworth BA, Gillespie MB, Day TA: Endoscopic resection of sinonasal hemangiomas and hemangiopericytomas. ORL J Otorhinolaryngol Relat Spec; 2006;68(2):69-72
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  • INTRODUCTION: Endoscopic resection of benign neoplasms, such as inverted papilloma, has been well described.
  • There are limited case reports of endoscopic resection of benign vascular tumors, including hemangiomas, or those with low-grade malignant potential, such as hemangiopericytomas.
  • Four tumors involved the skull base; 2 of these underwent preoperative embolization.
  • One patient had a CSF leak that occurred as the tumor was removed from the cribriform plate and that was successfully repaired intraoperatively.
  • The average size of the tumors was 5.8 cm x 2.7 cm with all tumors at least 2.5 cm in greatest dimension by computed tomography or magnetic resonance imaging.
  • The largest tumor was 12 cm in greatest dimension.
  • An average of 8 intraoperative frozen section margins was taken around 5 tumors, with all margins of each tumor clear on final pathology.
  • CONCLUSION: Large vascular neoplasms of the sinonasal cavity, such as hemangiomas and hemangiopericytomas, can be safely removed using endoscopic techniques.
  • [MeSH-major] Endoscopy / methods. Hemangioma / surgery. Hemangiopericytoma / surgery. Paranasal Sinus Neoplasms / surgery
  • [MeSH-minor] Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Skull Base Neoplasms / surgery. Treatment Outcome

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  • [Copyright] Copyright 2006 S. Karger AG, Basel.
  • (PMID = 16428897.001).
  • [ISSN] 0301-1569
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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49. Muzumdar D, Ventureyra EC: Tonsillar herniation and cervical syringomyelia in association with posterior fossa tumors in children: a case-based update. Childs Nerv Syst; 2006 May;22(5):454-9
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  • [Title] Tonsillar herniation and cervical syringomyelia in association with posterior fossa tumors in children: a case-based update.
  • BACKGROUND: Posterior fossa tumors most commonly occur in children.
  • The symptomatology is predominantly directed towards the tumor.
  • CASE REPORT: We describe a case of a pilocytic astrocytoma of the cerebellum in a 13-year-old girl who presented with clinical features of progressively worsening raised intracranial pressure and secondary tonsillar herniation and cervical syringomyelia.
  • Magnetic resonance (MR) imaging showed a large midline inhomogenously enhancing vermian tumor causing moderate obstructive hydrocephalus.
  • The tumor was resected through a suboccipital craniectomy.
  • CONCLUSIONS: The occurrence of tonsillar herniation and syringomyelia in association with a slow growing benign tumor like pilocytic astrocytoma of the cerebellum is uncommon.
  • Surgical extirpation of the tumor restores the normal cerebrospinal fluid circulation at the foramen magnum and produces an excellent outcome.
  • [MeSH-major] Astrocytoma. Hernia / etiology. Infratentorial Neoplasms / complications. Palatine Tonsil / pathology. Syringomyelia / etiology
  • [MeSH-minor] Adolescent. Disease Progression. Female. Humans. Magnetic Resonance Imaging

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  • (PMID = 16397818.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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50. Yang XJ, Zhou M, Hes O, Shen S, Li R, Lopez J, Shah RB, Yang Y, Chuang ST, Lin F, Tretiakova MM, Kort EJ, Teh BT: Tubulocystic carcinoma of the kidney: clinicopathologic and molecular characterization. Am J Surg Pathol; 2008 Feb;32(2):177-87
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  • The nature of tubulocystic carcinoma, a rare renal tumor composed of tubular and cystic structures, is poorly understood.
  • Furthermore, using gene expression microarray analysis, we defined the molecular signature of this tumor by comparing it with other renal tumors in our previously established molecular profile database.
  • Histologically, all 13 tumors were composed of closely packed tubules and cysts of varying sizes separated by fibrovascular septa.
  • The epithelial lining cells of the tubules and cysts in this tumor were characterized by abundant eosinophilic cytoplasm with prominent nucleoli often showing a hobnail appearance.
  • Therefore, based on its unique pathologic features and molecular signature as well as its biologic behavior to develop metastasis either by itself or in association with papillary RCC, tubulocystic carcinoma of the kidney should be recognized as a distinct subtype of RCC and be distinguished from other malignant and benign cystic lesions of the kidney.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Renal Cell / secondary. Chromosome Aberrations. Cystadenocarcinoma / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chromosomes, Human, Pair 17. Disease-Free Survival. Female. Fluorescent Antibody Technique, Indirect. Gene Expression Regulation, Neoplastic. Humans. Lymph Nodes / pathology. Male. Middle Aged. Neoplasms, Multiple Primary. Oligonucleotide Array Sequence Analysis

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  • (PMID = 18223319.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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51. D'Angelo VA, Galarza M, Catapano D, Monte V, Bisceglia M, Carosi I: Lateral ventricle tumors: surgical strategies according to tumor origin and development--a series of 72 cases. Neurosurgery; 2008 Jun;62(6 Suppl 3):1066-75
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  • [Title] Lateral ventricle tumors: surgical strategies according to tumor origin and development--a series of 72 cases.
  • OBJECTIVE: Optimal surgical management in lateral ventricle tumors remains controversial.
  • We conducted a retrospective study of patients with these lesions treated with a surgical strategy on the basis of tumor origin: primary or secondary ventricular and associated transependymal development.
  • METHODS: A total of 72 patients underwent surgery for lateral ventricle tumors.
  • Sixty-five percent of tumors were benign and low-grade tumors.
  • Final morbidity correlated well with preoperative clinical condition and pathological diagnosis.
  • CONCLUSION: Lateral ventricle tumors can be treated best by careful selection of the approach according to tumor origin and development.
  • Overall, the transcallosal approach is preferred, but in patients with transependymal growth or large primary or secondary ventricular tumors, the transcortical is a better option.

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  • [ReprintOf] Neurosurgery. 2005 Jan;56(1 Suppl):36-45; discussion 36-45 [15799791.001]
  • (PMID = 18695527.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. Shepherd CJ, Rizzo S, Ledaki I, Davies M, Brewer D, Attard G, de Bono J, Hudson DL: Expression profiling of CD133+ and CD133- epithelial cells from human prostate. Prostate; 2008 Jun 15;68(9):1007-24
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  • BACKGROUND: Recent evidence suggests that prostate stem cells in benign and tumor tissue express the cell surface marker CD133, but these cells have not been well characterized.
  • METHODS: We analyzed CD133-positive (CD133+) and -negative (CD133-) sub-populations of high-integrin expressing epithelial cells isolated from benign human prostate tissue and hormone-refractory prostate cancer (HRPC).
  • RESULTS: CD133+ cells freshly isolated from benign prostate tissue exhibited an expression profile characteristic of a putative stem/progenitor cell population, with transcripts involved in biological processes ranging from development and ion homeostasis to cell communication.
  • The profile of CD133- cells was consistent with that of a transit amplifying population, suggesting up-regulated proliferation and metabolism.
  • Comparison of benign populations to those from HRPC showed some similarities between CD133+ profiles but also revealed significant differences that provide a tumor-specific pattern, which included evidence of increased metabolic activity and active proliferation.
  • Subsequently, we demonstrated protein expression of a number of candidate genes in these cell populations and in benign tissue.
  • In a novel observation we also found expression of some of these markers in prostate tumors, including the oligodendrocyte lineage transcription factor OLIG1.
  • [MeSH-major] Antigens, CD / biosynthesis. Glycoproteins / biosynthesis. Prostatic Hyperplasia / immunology. Prostatic Neoplasms / immunology

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  • (PMID = 18398820.001).
  • [ISSN] 0270-4137
  • [Journal-full-title] The Prostate
  • [ISO-abbreviation] Prostate
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0501019
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AC133 Antigen; 0 / Antigens, CD; 0 / Glycoproteins; 0 / PROM1 protein, human; 0 / Peptides; 0 / RNA, Messenger
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53. Siniscalchi EN, Angileri FF, Mastellone P, Catalfamo L, Giusa M, Conti A, De Ponte FS, Tomasello F: Anterior skull base reconstruction with a galeal-pericranial flap. J Craniofac Surg; 2007 May;18(3):622-5
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  • Excision of neoplasm and trauma involving the anterior cranial base may often result in communication between the intracranial and extracranial compartments.
  • Ten underwent a combined maxillofacial-neurosurgical approach for the removal of a benign tumor involving the anterior skull base.
  • [MeSH-minor] Adult. Craniocerebral Trauma / surgery. Craniotomy. Facial Injuries / surgery. Female. Fibrin Tissue Adhesive / therapeutic use. Follow-Up Studies. Graft Survival. Humans. Magnetic Resonance Imaging. Male. Postoperative Complications. Retrospective Studies. Skull Base Neoplasms / surgery. Subdural Effusion / surgery. Tissue Adhesives / therapeutic use. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17538328.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fibrin Tissue Adhesive; 0 / Tissue Adhesives
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54. Ho H, Chen YD, Tan PH, Wang M, Lau WK, Cheng C: Inverted papilloma of urinary bladder: is long-term cystoscopic surveillance needed? A single center's experience. Urology; 2006 Aug;68(2):333-6
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  • IP is an uncommon benign tumor of the urinary tract.
  • No patient had a synchronous or previous bladder tumor.
  • All were solitary tumors, most commonly found at the bladder neck.
  • CONCLUSIONS: Although our cases exhibited benign biologic behavior, the presence of cytologic atypia and suspicious urine cytology require exclusion of TCC with an inverted pattern.
  • [MeSH-major] Cystoscopy. Papilloma, Inverted / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 16904447.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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55. Bornemann A, Koitschev A: A 57-year-old female with a benign tumor in the ethmoid sinus. Brain Pathol; 2006 Oct;16(4):335-6
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  • [Title] A 57-year-old female with a benign tumor in the ethmoid sinus.
  • [MeSH-major] Ethmoid Sinus / pathology. Neurocytoma / pathology. Paranasal Sinus Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged. Mucocele / pathology. Tomography, X-Ray Computed

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  • (PMID = 17107604.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
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56. Rachappa MM, Triveni MN: Capillary hemangioma or pyogenic granuloma: A diagnostic dilemma. Contemp Clin Dent; 2010 Apr;1(2):119-22
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  • Pyogenic granulomas and hemangiomas of oral cavity are well-known benign lesions.
  • The clinical diagnosis of such an uncommon occurrence can be quite challenging as they sometimes may mimic more serious lesions such as malignancies.
  • The purpose of this article is to report an unusual case of benign tumor occurring on hard palate which was clinically diagnosed as pyogenic granuloma and histopathologically as capillary hemangioma.

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  • (PMID = 22114397.001).
  • [ISSN] 0976-2361
  • [Journal-full-title] Contemporary clinical dentistry
  • [ISO-abbreviation] Contemp Clin Dent
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3220083
  • [Keywords] NOTNLM ; Capillary hemangioma / portwine stain / pyogenic granuloma / vascular malformations
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57. Xue Q, Wang J: Recurrent respiratory papillomatosis arising in trachea not affecting larynx. Intern Med; 2010;49(15):1649-51
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  • Recurrent respiratory papillomatosis (RRP) is an infrequent benign neoplasm commonly involving the upper respiratory tract with laryngeal predilection.
  • The diagnosis and treatment of this disease are challenging due to its nonspecific clinical presentations and recurrent nature.
  • Our experiences indicate that a high awareness of RRP and proper consideration in the right clinical context are prerequisites for early diagnosis, and a combination of multiple treatment modalities should be considered as a feasible treatment regimen.
  • [MeSH-major] Larynx. Tracheal Neoplasms / diagnosis
  • [MeSH-minor] Child. Humans. Male. Papillomavirus Infections / diagnosis. Papillomavirus Infections / prevention & control. Papillomavirus Infections / surgery. Respiratory Tract Infections / diagnosis. Respiratory Tract Infections / prevention & control. Respiratory Tract Infections / surgery. Secondary Prevention

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  • (PMID = 20686308.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] Recurrent respiratory papillomatosis
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58. Singhal A, Kanagala R, Wright HI, Kohli V: Multiple bile duct hamartomas mimicking diffuse hepatic metastasis: GI image. J Gastrointest Surg; 2010 Oct;14(10):1629-31
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  • Bile duct hamartomas (von Meyenburg complex) are the rare benign neoplasm of the liver due to dysembryogenesis; constituted historically, cystic dilatations of the bile duct encompassed by fibrous stroma.
  • Magnetic resonance cholangiography has been suggested as the best investigation for their imaging diagnosis.
  • [MeSH-major] Bile Duct Diseases / pathology. Gallstones / surgery. Hamartoma / pathology. Liver Neoplasms / diagnosis
  • [MeSH-minor] Cholecystectomy, Laparoscopic. Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 20480252.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. Sterker I, Hagert-Winkler A, Gradistanac T, Frerich B: [Granular cell tumor of the orbit]. Ophthalmologe; 2007 Sep;104(9):803-5
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  • [Title] [Granular cell tumor of the orbit].
  • Granular cell tumor (GCT, Abrikossoff tumor) is an extremely rare, benign tumor with a neurogenic origin occurring most commonly in the upper aerodigestive tract.
  • [MeSH-major] Granular Cell Tumor. Orbital Neoplasms

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  • (PMID = 17440732.001).
  • [ISSN] 0941-293X
  • [Journal-full-title] Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • [ISO-abbreviation] Ophthalmologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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60. Berlingieri MT, Pallante P, Sboner A, Barbareschi M, Bianco M, Ferraro A, Mansueto G, Borbone E, Guerriero E, Troncone G, Fusco A: UbcH10 is overexpressed in malignant breast carcinomas. Eur J Cancer; 2007 Dec;43(18):2729-35
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  • Subsequently, a clear correlation between UbcH10 overexpression and a reduced survival in ovarian carcinoma patients has been described indicating UbcH10 as a valid prognostic marker in this neoplastic disease.
  • Here we have extended the analysis of the UbcH10 expression to neoplastic breast diseases.
  • We demonstrated, by tissue micro-arrays immunohistochemical studies, a significant difference (p=0.0001) in the mean percentage of UbcH10 stained cells between benign (0.22%) and malignant (11.01%) neoplastic lesions.
  • Therefore, these results suggest the perspective of a therapy of aggressive breast carcinomas based on the suppression of the UbcH10 function.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Breast Neoplasms / enzymology. Ubiquitin-Conjugating Enzymes / metabolism
  • [MeSH-minor] Blotting, Western. Cell Division. Cell Line, Tumor. Genes, erbB-2 / genetics. Humans. Immunohistochemistry. Prognosis. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17933517.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 6.3.2.19 / UBE2C protein, human; EC 6.3.2.19 / Ubiquitin-Conjugating Enzymes
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61. Tsokos M, Erbersdobler A: Pathology of peliosis. Forensic Sci Int; 2005 Apr 20;149(1):25-33
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  • Concerning the underlying pathogenetic mechanisms of onset and maintenance of peliosis, the morphological data obtained by different investigators suggest that there is more than one path of formal pathogenesis (e.g., congenital malformation of vessels manifesting under altered local intravascular pressure conditions, acquired vascular disorder triggered by toxic noxae, active proliferation of vessels corresponding to the benign end on the spectrum of neoplastic vascular lesions).
  • One of the differential diagnoses that most closely resembles peliosis hepatis is secondary hepatic congestion due to veno-occlusive disease or the Budd-Chiari syndrome.
  • Since the disease may culminate in spontaneous rupture of the affected organ and thus may mimic a violent death at autopsy, peliosis is far more than just another morphological curiosity.
  • [MeSH-minor] Bone Marrow Diseases / pathology. Diagnosis, Differential. Humans. Kidney Diseases / pathology. Lung Diseases / pathology. Lymphatic Diseases / pathology. Parathyroid Diseases / pathology. Splenic Diseases / pathology

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  • (PMID = 15734106.001).
  • [ISSN] 0379-0738
  • [Journal-full-title] Forensic science international
  • [ISO-abbreviation] Forensic Sci. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Number-of-references] 47
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62. Metser U, Even-Sapir E: Increased (18)F-fluorodeoxyglucose uptake in benign, nonphysiologic lesions found on whole-body positron emission tomography/computed tomography (PET/CT): accumulated data from four years of experience with PET/CT. Semin Nucl Med; 2007 May;37(3):206-22
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  • [Title] Increased (18)F-fluorodeoxyglucose uptake in benign, nonphysiologic lesions found on whole-body positron emission tomography/computed tomography (PET/CT): accumulated data from four years of experience with PET/CT.
  • The use of (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET) in the field of oncology is rapidly evolving; however, (18)F-FDG is not tumor specific.
  • Aside from physiological uptake (18)F-FDG also may accumulate in benign processes.
  • Knowledge of these (18)F-FDG-avid nonmalignant lesions is essential for accurate PET interpretation in oncologic patients to avoid a false-positive interpretation.
  • Through the systematic review of the reports of PET/computed tomography (CT) studies performed in oncologic patients during a 6-month period, we found benign nonphysiological uptake of (18)F-FDG in more than 25% of studies.
  • A total of 73% of benign lesions were inflammatory in nature, with post-traumatic bone and soft-tissue abnormalities (including iatrogenic injury) and benign tumors accounting for the remainder.
  • The differentiation of benign from malignant uptake of (18)F-FDG on PET alone may be particularly challenging as a result of the low anatomical resolution of PET and paucity of anatomical landmarks.
  • Familiarity with (18)F-FDG-avid nonmalignant lesions also may extend the use of (18)F-FDG-PET imaging beyond the field of oncology.
  • We have tabulated our experience with benign entities associated with increased (18)F-FDG uptake on whole-body PET/CT from 12,000 whole-body (18)F-FDG-PET/CT studies performed during a 4-year period.
  • [MeSH-major] Fluorodeoxyglucose F18 / pharmacokinetics. Inflammation / diagnosis. Inflammation / metabolism

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  • (PMID = 17418153.001).
  • [ISSN] 0001-2998
  • [Journal-full-title] Seminars in nuclear medicine
  • [ISO-abbreviation] Semin Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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63. Németh I, Sükösd F, Béli L, Kiss A, Pajor L, Mikó T, Iványi B: [Adult renal neoplasms in the material of the Pathology Department of the Szeged University]. Orv Hetil; 2005 Apr 3;146(14):653-8
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  • [Title] [Adult renal neoplasms in the material of the Pathology Department of the Szeged University].
  • AIMS: The authors investigated the frequencies of the various histological types of adult renal tumours.
  • RESULTS: 86.7% of all the tumours (n = 407) were malignant.
  • Among the malignant tumours, the frequency of renal cell carcinomas was 91.1% (n = 371).
  • The authors observed 3 Bellini duct, 1 mucinous tubular and 3 non-classifiable carcinomas, with a combined incidence of 1.8%.
  • As far as benign tumours are concerned (13.2%, n = 62), oncocytomas (n = 37, 7.8% of all the tumours) affected mainly females, whereas angiomyolipomas (n = 21, 4.4% of all the tumours) occurred in females only.
  • In 13 oncocytoma cases, the tumours were initially diagnosed as malignant.
  • CONCLUSIONS: Adult malignant renal tumours affect mainly patients around the age of 60.
  • The commonest diagnosis was clear cell carcinoma of conventional type.
  • [MeSH-major] Carcinoma / epidemiology. Carcinoma / pathology. Kidney Neoplasms / epidemiology. Kidney Neoplasms / pathology

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  • (PMID = 15889540.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
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64. Lanza A, Laino L, Rossiello L, Perillo L, Ermo AD, Cirillo N: Clinical Practice: Giant Cell Tumour of the Jaw Mimicking Bone Malignancy on Three-Dimensional Computed Tomography (3D CT) Reconstruction. Open Dent J; 2008;2:73-7
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  • [Title] Clinical Practice: Giant Cell Tumour of the Jaw Mimicking Bone Malignancy on Three-Dimensional Computed Tomography (3D CT) Reconstruction.
  • Periapical inflammation, cysts and benign tumours, bone malignancies, all of these conditions may show bone resorption on radiograph.
  • Features of the surrounding bone, margins of the lesion, and biological behaviour including tendency to infiltration and root resorption, may represent important criteria for distinguishing benign tumours from their malign counterpart, although the radiographic aspect of the lesion is not always predictive.
  • Therefore a critical differential diagnosis has to be reached to choose the best management.
  • Here, we report a case of giant cell tumour (GCT) whose radiological features by computed tomography (CT) suggested the presence of bone malignancy, whereas the evaluation of a routine OPT scan comforted us about the benign nature of the lesion.
  • A brief review of the literature on such a benign but locally aggressive neoplasm is also provided.

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  • [Cites] Acta Otorhinolaryngol Ital. 2004 Feb;24(1):26-9 [15270430.001]
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  • (PMID = 19088886.001).
  • [ISSN] 1874-2106
  • [Journal-full-title] The open dentistry journal
  • [ISO-abbreviation] Open Dent J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2581533
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65. Hakverdi S, Dolapçioğlu K, Güngören A, Yaldiz M, Hakverdi AU: Multiple uterine angioleiomyomas mimicking an ovarian neoplasm: a case report. Eur J Gynaecol Oncol; 2009;30(5):592-4
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  • [Title] Multiple uterine angioleiomyomas mimicking an ovarian neoplasm: a case report.
  • Angioleiomyoma is a rare benign neoplasm that originates from smooth muscle cells and contains thick-walled blood vessels.
  • On pathologic examination of the specimen, the tumor was diagnosed as an angioleiomyoma.
  • Here, we present a case of giant-multiple uterine angioleiomyomas mimicking an ovarian neoplasm.
  • [MeSH-major] Angiomyoma / diagnosis. Angiomyoma / pathology. Ovarian Neoplasms / diagnosis. Uterine Diseases / diagnosis. Uterine Diseases / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Hysterectomy. Ovariectomy

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  • (PMID = 19899426.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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66. Kamiyama K, Usui S, Kimura M: [Thoracoscopic surgery combined with a supraclavicular approach for removing left superior mediastinal neurogenic tumor]. Kyobu Geka; 2009 Sep;62(10):880-3
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  • [Title] [Thoracoscopic surgery combined with a supraclavicular approach for removing left superior mediastinal neurogenic tumor].
  • Chest computed tomography (CT) scan and magnetic resonance imaging (MRI) revealed a left upper mediastinal mass at the Th1 to Th2 level, measuring 30 mm in size, which was suspected to be a neurogenic tumor.
  • Surgical removal of the tumor using thoracoscopic procedure through 3 chest ports combined with a supraclavicular approach was successfully performed.
  • A pathological examination revealed the tumor to be benign neurilemmoma.
  • [MeSH-major] Mediastinal Neoplasms / surgery. Neurilemmoma / surgery

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  • (PMID = 19764493.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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67. Kondo T, Kajimoto S, Okuda H, Toma H, Tanabe K: A case of granular cell tumor of the bladder successfully managed with extraperitoneal laparoscopic surgery. Int J Urol; 2006 Jun;13(6):827-8
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  • [Title] A case of granular cell tumor of the bladder successfully managed with extraperitoneal laparoscopic surgery.
  • Granular cell tumor is a benign neoplasm which frequently occurs in the oral cavity, skin, and subcutaneous tissue.
  • Granular cell tumor of the bladder is an extremely rare disease, and only nine cases have been reported.
  • We present here an additional case of granular cell tumor occurring in the bladder.
  • Unlike the other tumors reported, this tumor extruded into the Retzius' cavity.
  • Therefore, the tumor was successfully excised through extraperitoneal laparoscopic surgery.
  • The small tumor located in Retzius' cavity could be managed with extraperitoneal laparoscopic surgery.
  • [MeSH-major] Granular Cell Tumor / therapy. Laparoscopy. Urinary Bladder Neoplasms / therapy

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  • (PMID = 16834673.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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68. Liu CL, Lai PL, Jung SM, Liao CC: Thoracic ossified meningioma and osteoporotic burst fracture: treatment with combined vertebroplasty and laminectomy without instrumentation: case report. J Neurosurg Spine; 2006 Mar;4(3):256-9
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  • Although spinal meningioma is a common benign neoplasm, the ossified variant is rare.
  • The tumor was completely removed by T10-11 laminectomy and transpedicular vertebroplasty was performed.
  • [MeSH-major] Laminectomy / methods. Meningeal Neoplasms / complications. Meningeal Neoplasms / surgery. Meningioma / complications. Meningioma / surgery. Spinal Neoplasms / complications. Spinal Neoplasms / surgery

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  • (PMID = 16572627.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Yoo KH, Kim BJ, Rho YK, Lee JW, Kim YJ, Kim MN, Song KY: A case of diffuse neurofibroma of the scalp. Ann Dermatol; 2009 Feb;21(1):46-8
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  • A neurofibroma is a benign tumor of the peripheral nerve sheath characterized by proliferation of Schwann cells, perineural cells, and endoneurial fibroblasts.
  • Neurofibromas can involve any site on the body skin.
  • We present a case of a 10-year-old boy who had a diffuse neurofibroma on the scalp.

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  • (PMID = 20548855.001).
  • [ISSN] 2005-3894
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2883368
  • [Keywords] NOTNLM ; Diffuse neurofibroma / Scalp
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70. Zhu HN, Yu JP, Luo J, Jiang YH, Li JQ, Sun WY: Gastric adenomyoma presenting as melena: a case report and literature review. World J Gastroenterol; 2010 Apr 21;16(15):1934-6
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  • Gastric adenomyoma (AM) is a rare benign tumor characterized by gland-like structures embedded within a smooth muscle stroma.
  • We report a case of a 68-year-old man with gastric AM admitted to our hospital for melana.
  • Although gastric AM is rare, it should be considered in differential diagnosis of extramucosal gastric tumor.
  • [MeSH-major] Adenomyoma / diagnosis. Adenomyoma / therapy. Melena / diagnosis. Stomach Neoplasms / diagnosis. Stomach Neoplasms / therapy
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Endoscopy / methods. Endoscopy, Gastrointestinal / methods. Humans. Microscopy / methods. Muscle, Smooth / pathology

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  • (PMID = 20397275.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 11
  • [Other-IDs] NLM/ PMC2856838
  • [Keywords] NOTNLM ; Adenomyoma / Endoscopic examination / Histopathology / Melana / Stomach
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71. Sakurai H, Kaji M, Mukai K, Suemasu K: Ectopic hamartomatous thymoma--a truly rare neoplasm: report of a case. Surg Today; 2010;40(2):146-9
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  • [Title] Ectopic hamartomatous thymoma--a truly rare neoplasm: report of a case.
  • An ectopic hamartomatous thymoma is an extremely rare benign neoplasm that commonly occurs in the lower neck region.
  • This report presents a case of a 26-year-old man with ectopic hamartomatous thymoma in the left supraclavicular region, and discusses the current knowledge regarding this type of lesion.
  • Clinicians as well as pathologists should be aware of the existence of this disease so that it can be identified correctly.
  • [MeSH-major] Choristoma / pathology. Hamartoma / pathology. Thymoma / pathology. Thymus Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Treatment Outcome. Ultrasonography

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  • (PMID = 20107954.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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72. Joshi D, Gangane N, Kishore S, Vagha S: Unusual histological presentation in neurofibromas: Two case reports. Cases J; 2008;1(1):188
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  • Histological examination of case no.1 revealed a benign tumor of the peripheral nerve sheath, of neurofibroma type with presence of mucus producing glands.
  • The epithelial component was benign in this case.

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  • (PMID = 18823533.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2565668
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73. Garnacho Saucedo GM, Moreno Jiménez JC, Jiménez Puya R, Rodríguez Bujaldon A: Therapeutic Hotline: Topical glycopyrrolate: a successful treatment for craniofacial hyperhidrosis and eccrine hidrocystomas. Dermatol Ther; 2010 Jan-Feb;23(1):94-7
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  • Eccrine hidrocystoma is a benign tumor derived from eccrine sudoriparous glands.
  • Multiple hidrocystomas are unusual and have been associated with Graves' disease, Parkinson's disease, and idiopathic craniofacial hyperhidrosis.
  • [MeSH-major] Eyelid Neoplasms / drug therapy. Glycopyrrolate / therapeutic use. Hidrocystoma / drug therapy. Hyperhidrosis / drug therapy. Muscarinic Antagonists / therapeutic use. Sweat Gland Neoplasms / drug therapy

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  • (PMID = 20136914.001).
  • [ISSN] 1529-8019
  • [Journal-full-title] Dermatologic therapy
  • [ISO-abbreviation] Dermatol Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Muscarinic Antagonists; V92SO9WP2I / Glycopyrrolate
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74. Smolka W, Eggensperger N, Stauffer-Brauch EJ, von Bredow F, Lizuka T: Pleomorphic adenoma in an atypical location near the temporomandibular joint: a case report. Quintessence Int; 2007 May;38(5):417-21
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  • The tumor was solitary, closely attached to the capsule of the TMJ and superior to the parotid gland, with clear demarcation.
  • Clinically, the tumor resembled TMJ pathology, but MRI examination led to diagnosis of a benign tumor attached to the TMJ.
  • This report shows that pleomorphic adenoma can be a possible diagnosis for lesions at the joint capsule.
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male

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  • (PMID = 17568841.001).
  • [ISSN] 1936-7163
  • [Journal-full-title] Quintessence international (Berlin, Germany : 1985)
  • [ISO-abbreviation] Quintessence Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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75. Thejasvi K, Niveditha SR, Suguna BV, Hemalata M, Kusuma V: Cytomorphology of hibernoma: a report of 2 cases. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):875-8
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  • BACKGROUND: Hibernoma, a benign neoplasm of the brown fat, clinically and radiologically can mimic a lipoma or liposarcoma, especially in the retroperitoneum.
  • As treatment modalities vary, an accurate preoperative diagnosis may help the surgeon to plan treatment.
  • CONCLUSION: FNA is a highly sensitive and specific tool for the diagnosis of hibernoma.

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  • (PMID = 21053560.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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76. Kondo T: A case of lipomatous pleomorphic adenoma in the parotid gland: a case report. Diagn Pathol; 2009;4:16
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  • INTRODUCTION: Pleomorphic adenoma is the most common benign neoplasm of the salivary glands.
  • Extensive lipomatous involvement of the tumor is, however, a very rare finding.
  • CASE REPORT: Herein, a rare case of lipomatous pleomorphic adenoma arising in the parotid gland of a 14-year-old Japanese woman is presented.
  • Recognition of this rare subtype of pleomorphic adenoma is important for clinical diagnosis and management.

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  • [Cites] Histopathology. 1995 Sep;27(3):285-8 [8522295.001]
  • [Cites] Histopathology. 1996 Jan;28(1):87-9 [8838128.001]
  • [Cites] J Oral Pathol Med. 2004 Jan;33(1):53-5 [14675141.001]
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  • (PMID = 19497106.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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77. De Padua M, Gupta N, Broor SL, Govil D: Duodenal angiomyolipoma: a case report. Indian J Pathol Microbiol; 2007 Jul;50(3):568-9
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  • Angiomyolipoma is a benign neoplasm, the most common site being the kidney.
  • [MeSH-major] Angiomyolipoma / diagnosis. Duodenum / pathology. Intestinal Neoplasms / diagnosis

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  • [CommentIn] Indian J Pathol Microbiol. 2010 Oct-Dec;53(4):859 [21045449.001]
  • (PMID = 17883138.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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78. Karabakhtsian R, Heller D, Hameed M, Bethel C: Periosteal chondroma of the rib--report of a case and literature review. J Pediatr Surg; 2005 Sep;40(9):1505-7
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  • [Title] Periosteal chondroma of the rib--report of a case and literature review.
  • Periosteal chondroma is a rare benign tumor of hyaline cartilage.

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  • (PMID = 16150361.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Chung SW, Kwon SY, Jung KY, Woo JS: Synchronous double primary cancers of the unilateral parotid gland. Acta Otolaryngol; 2007 Feb;127(2):209-12
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  • Synchronous parotid neoplasms, especially synchronous neoplasms of two separate and histologically different types, are extremely uncommon.
  • A review of the literature revealed that most reported cases were either a combination of two distinct benign neoplasms or a benign neoplasm and another malignant tumor.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Mucoepidermoid / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology

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  • (PMID = 17364354.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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80. Wouda RM, Chalkley MD, Fraser AR, Moses PA: Hepatic myelolipoma incarcerated in a peritoneopericardial diaphragmatic hernia in a cat. Aust Vet J; 2010 Jun;88(6):231-5
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  • Myelolipoma is an extremely rare benign tumour, composed of extramedullary haematopoietic cells and adipose tissue.
  • Myelolipomas are hypothesised to result from metaplastic alteration, rather than a neoplastic process, although this theory cannot be substantiated.

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  • (PMID = 20553572.001).
  • [ISSN] 1751-0813
  • [Journal-full-title] Australian veterinary journal
  • [ISO-abbreviation] Aust. Vet. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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81. Miller DV, Wang H, Wang H, Fealey ME, Tazelaar HD: Beta-catenin mutations do not contribute to cardiac fibroma pathogenesis. Pediatr Dev Pathol; 2008 Jul-Aug;11(4):291-4
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  • Cardiac fibromas are the 2nd most common benign cardiac tumor occurring in children and bear a striking morphologic resemblance to soft tissue or desmoid fibromatosis.
  • Nine cardiac fibromas from patients with surgical resection were examined for beta-catenin mutations by immunoperoxidase staining for beta-catenin protein and DNA sequencing of a region in exon 3 of the beta-catenin gene, where relatively conserved mutations have been described in desmoid fibromatosis.
  • The beta-catenin exon 3 sequence data showed no mutations in any of the 9 tumors.
  • We conclude that despite their morphologic similarity, cardiac fibroma and desmoid fibromatosis do not share this common molecular pathway of neoplastic growth.
  • [MeSH-major] Fibroma / genetics. Genetic Predisposition to Disease. Heart Neoplasms / genetics. beta Catenin / genetics
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Child. Child, Preschool. DNA Mutational Analysis. DNA, Neoplasm / analysis. Female. Humans. Immunoenzyme Techniques. Infant. Male. Mutation

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  • (PMID = 18078366.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / beta Catenin
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82. Giunippero A, Maya AM, Gallo A, Bazzana MS, Cosentino V, Aulet FJ: [Mesenchymal hamartoma of the liver in an elderly man]. Medicina (B Aires); 2009;69(5):554-6
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  • [Transliterated title] Hamartoma mesenquimatoso hepático en un anciano.
  • The mesenchymal hamartoma of the liver is a non frequent benign tumor with a ductal plate malformation, consisting of myxoid mesenchymal tissue and abnormal bile ducts in different proportion.
  • [MeSH-major] Hamartoma / diagnosis. Liver Diseases / diagnosis

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  • (PMID = 19897442.001).
  • [ISSN] 0025-7680
  • [Journal-full-title] Medicina
  • [ISO-abbreviation] Medicina (B Aires)
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Argentina
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83. Coriat R, Mozer-Bernardeau M, Terris B, Chryssostalis A, Prat F, Chaussade S: Endoscopic resection of a large Brunner's gland hamartoma. Gastroenterol Clin Biol; 2008 Jan;32(1 Pt. 1):11-4
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  • [Title] Endoscopic resection of a large Brunner's gland hamartoma.
  • Brunner's Gland Hamartoma (BGH) is a benign tumor of the duodenum that can lead to gastrointestinal bleeding and intestinal obstruction.
  • We describe the case of a duodenal obstruction caused by a large BGH (6 cm x 4 cm).
  • Endoscopic ultrasound (EUS) revealed a submucosal duodenal tumor.

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  • (PMID = 18341972.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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84. Saifzadeh S, Derakhshanfar A, Hadian M: Congenital lipoblastoma in a neonate calf: first report in veterinary literature. Vet Dermatol; 2007 Apr;18(2):130-3
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  • Lipoblastoma is a rare benign tumour of adipose tissue that usually occurs in young children.
  • This case report describes the clinical and histopathological findings of a congenital lipoblastoma located at the tail base of a 2-day-old male calf.
  • Lipoblastoma should thus be considered in the differential diagnosis list for congenital adipose tissue tumours in animals.
  • [MeSH-major] Cattle Diseases / diagnosis. Lipoma / veterinary. Skin Neoplasms / veterinary
  • [MeSH-minor] Animals. Animals, Newborn. Cattle. Diagnosis, Differential. Male. Tail

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  • (PMID = 17355429.001).
  • [ISSN] 0959-4493
  • [Journal-full-title] Veterinary dermatology
  • [ISO-abbreviation] Vet. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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85. Pacelli J, Whitaker CH: Brachial plexopathy due to malignant peripheral nerve sheath tumor in neurofibromatosis type 1: case report and subject review. Muscle Nerve; 2006 May;33(5):697-700
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  • [Title] Brachial plexopathy due to malignant peripheral nerve sheath tumor in neurofibromatosis type 1: case report and subject review.
  • Neurofibromatosis type 1 (NF1) is a common tumor predisposition syndrome affecting approximately 1 in 4,000 persons.
  • It is an autosomal-dominant disorder with half of the cases resulting from spontaneous mutations.
  • This genetic defect leads to the formation of benign tumors or neurofibromas of the peripheral nervous system.
  • In this report, we illustrate this point by presenting a patient who developed acute shoulder pain and weakness due to malignant degeneration of a plexiform neurofibroma involving the left brachial plexus, and review the literature on this subject.
  • [MeSH-major] Brachial Plexus Neuropathies / etiology. Nerve Sheath Neoplasms / complications. Neurofibromatosis 1 / complications


86. Burkhart CG, Burkhart CN: Use of a keratolytic agent with occlusion for topical treatment of hyperkeratotic seborrheic keratoses. Skinmed; 2008 Jan-Feb;7(1):15-8
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  • [Title] Use of a keratolytic agent with occlusion for topical treatment of hyperkeratotic seborrheic keratoses.
  • BACKGROUND: Seborrheic keratoses are the most common benign tumors in adults.

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  • (PMID = 18174808.001).
  • [ISSN] 1540-9740
  • [Journal-full-title] Skinmed
  • [ISO-abbreviation] Skinmed
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratolytic Agents
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87. Thakur JS, Mohindroo NK, Mohindroo S, Sharma DR, Thakur A: Pleomorphic adenoma of minor salivary gland with therapeutic misadventure: a rare case report. BMC Ear Nose Throat Disord; 2010;10:2
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  • BACKGROUND: The benign tumors of nasopharynx are least encountered tumors in otolaryngology, as nasopharynx is considered one of notorious anatomical site for the malignant tumors.
  • On CT scan, this tumor was quite big and extending to the parapharyngeal space.
  • The excision biopsy of tumor revealed it as pleomorphic adenoma.
  • We found only five published reports on this tumor arising from nasopharynx.
  • DISCUSSION AND CONCLUSION: Although, in this case report exact origin of the tumor could not be ascertained as it also appeared to be a parapharyngeal tumor but we kept the possibility of a nasopharyngeal tumor on the basis of clinical features.
  • It can be misdiagnosed as malignant epithelial tumor on histopathology.
  • A possibility of benign tumor should always be kept in nasopharyngeal growth with no evidence of metastasis, and histopathological diagnosis of growth should be available before any definitive treatment.

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  • [Cites] Cancer. 1977 May;39(5):2209-30 [192443.001]
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  • (PMID = 20157428.001).
  • [ISSN] 1472-6815
  • [Journal-full-title] BMC ear, nose, and throat disorders
  • [ISO-abbreviation] BMC Ear Nose Throat Disord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2821363
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88. Kelly JJ: Peripheral neuropathies associated with monoclonal gammopathies of undetermined significance. Rev Neurol Dis; 2008;5(1):14-22
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  • An MG is a proliferation of a single clone of neoplastic or nonneoplastic plasma that usually secretes a monoclonal protein (M-protein) serum or urine.
  • If a diagnosis of monoclonal gammopathy of undetermined significance (MGUS) is established, a sudden increase in M-protein levels can indicate malignant transformation of a benign PCD.
  • MGUS is the most common of the PCDs associated with neurologic disorders, which are easily approached clinically by classifying them as IgM or non-IgM types.
  • [MeSH-minor] Antibodies, Anti-Idiotypic / blood. Antibodies, Anti-Idiotypic / immunology. Autoimmune Diseases / complications. Autoimmune Diseases / immunology. Cryoglobulinemia / blood. Cryoglobulinemia / complications. Cryoglobulinemia / immunology. Humans. Motor Neuron Disease / blood. Motor Neuron Disease / complications. Motor Neuron Disease / immunology

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  • (PMID = 18418318.001).
  • [ISSN] 1545-2913
  • [Journal-full-title] Reviews in neurological diseases
  • [ISO-abbreviation] Rev Neurol Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Anti-Idiotypic; 0 / Blood Proteins; 0 / Immunoglobulins
  • [Number-of-references] 85
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89. Hałoń A, Patrzałek DJ, Boratyńska M, Wolański M, Hałoń Ł: Kidney donation from a patient with cardiac myxoma: a case report. Transplant Proc; 2008 May;40(4):1073-8
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  • A significant percentage of donors may be found among patients primarily suffering from benign neoplasms whose nature does not show malignant potential and do not metastasize.
  • CONCLUSION: Patients with myxoma should be accepted as donors, since the risk of dying on the waiting list is greater than the tumor transfer risk.
  • [MeSH-major] Heart Neoplasms / ultrasonography. Kidney. Kidney Transplantation / physiology. Myxoma / ultrasonography. Tissue Donors

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  • (PMID = 18555118.001).
  • [ISSN] 0041-1345
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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90. Nakayama Y, Inoue H, Hamada Y, Takeshita M, Iwasaki H, Maeshiro K, Iwanaga S, Tani H, Ryu S, Yasunami Y, Ikeda S: Intraductal tubular adenoma of the pancreas, pyloric gland type: a clinicopathologic and immunohistochemical study of 6 cases. Am J Surg Pathol; 2005 May;29(5):607-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The intraductal tubular adenoma (ITA), pyloric gland type, of the pancreas is an uncommon benign tumor, akin to the pyloric gland type adenoma of the gallbladder.
  • Grossly, all tumors formed a localized polypoid mass protruding into the lumen of the dilated pancreatic duct.
  • Five of the six tumors were found within the main duct, and the other arose within the branch duct of the pancreas.
  • Microscopically, the tumors were composed of closely packed tubular glands resembling pyloric type glands.
  • Histochemically, the tumors largely showed neutral mucin with a lesser amount of acidic mucin made up mainly of sialomucin.
  • Endocrine cells were found in five tumors.
  • Immunohistochemically, all tumors were labeled with M-GGMC-1 and MUC6, whereas MUC1 and MUC2 stains were negative.
  • Pepsinogen II was positive in 5 tumors; thus, the results displayed a pattern of differentiation similar to those of ordinary gastric pyloric or metaplastic pyloric glands.
  • DPC4 expression was maintained in all tumors and p53-positive nuclei were hardly encountered.
  • All patients are alive with no evidence of disease 3 to 10.5 years after surgical resection.
  • [MeSH-major] Adenoma / pathology. Gastric Mucosa / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. DNA-Binding Proteins / analysis. Epithelial Cells / pathology. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Mucins / analysis. Mucins / classification. Pancreaticoduodenectomy. Pepsinogen A / analysis. Smad4 Protein. Trans-Activators / analysis. Treatment Outcome. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 15832084.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Mucins; 0 / SMAD4 protein, human; 0 / Smad4 Protein; 0 / Trans-Activators; 0 / Tumor Suppressor Protein p53; 9001-10-9 / Pepsinogen A
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91. Rhee DK, Park SH, Jang YK: Molecular signatures associated with transformation and progression to breast cancer in the isogenic MCF10 model. Genomics; 2008 Dec;92(6):419-28
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  • We utilized gene expression profiling to define molecular signatures associated with transformation and cancer progression in a series of isogenic human breast cancer cell lines including a normal, benign, noninvasive and invasive carcinoma.
  • Exogenous expressions of S100A8 and S100A9 inhibit growth in benign and noninvasive carcinoma cells, suggesting their negative role in cell proliferation.
  • [MeSH-major] Biomarkers, Tumor / genetics. Breast Neoplasms / genetics. Cell Transformation, Neoplastic / genetics. Epigenesis, Genetic. Gene Expression Profiling / statistics & numerical data. Gene Expression Regulation, Neoplastic
  • [MeSH-minor] Cell Line, Tumor. Cell Proliferation. Cluster Analysis. Disease Progression. Humans. Models, Genetic. Oligonucleotide Array Sequence Analysis / statistics & numerical data. Prognosis


92. Ekşi E, Oztop I: Nerve sheath myxoma of the upper lip: a case report. Kulak Burun Bogaz Ihtis Derg; 2010 Nov-Dec;20(6):318-20
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  • Nerve sheath myxoma is a benign tumor that rarely occurs in the lip area.
  • Although very rare, nerve sheath myxoma should be considered in the differential diagnosis of lip mass and widely excised to avoid local recurrence.
  • [MeSH-major] Lip Neoplasms / surgery. Neurothekeoma / surgery
  • [MeSH-minor] Adult. Cell Division. Female. Humans. Neoplasm Recurrence, Local / prevention & control. S100 Proteins / analysis. Treatment Outcome

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  • (PMID = 20961288.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / S100 Proteins
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93. Kubyshkin VA, Vishnevskiĭ VA, Grishankov SA, Shevchenko TV: [Median resection of pancreas]. Khirurgiia (Mosk); 2007;(10):10-4
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  • Experience of 16 median resections of pancreas due to serous or mucinous benign cystic tumor (13 patients) or small afunctional neuroendocrine tumor (3 patients) is analyzed.
  • There were no recurrences of tumor.
  • It is concluded that median resection of pancreas is effective and safe surgical operation for the patients with localization of benign tumor at the zone of pancreatic istmus.
  • [MeSH-major] Cystadenoma, Mucinous / surgery. Neuroendocrine Tumors / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery

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  • (PMID = 18163044.001).
  • [ISSN] 0023-1207
  • [Journal-full-title] Khirurgiia
  • [ISO-abbreviation] Khirurgiia (Mosk)
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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94. Khadilkar UN, Kumar S, Prabhu PP, Kamath M: Mucoepidermoid carcinoma of lung: a case report. Indian J Pathol Microbiol; 2007 Jul;50(3):560-2
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  • Mucoepidermoid lung tumours are uncommon neoplasms comprising of 0.2% of all the lung tumours and historically included under the term bronchial adenomas.
  • This is a case report of a bronchial tumour in the hilar region present since 3 years.
  • The neoplasm could be easily classified as a mucoepidermoid tumour of low malignant potential, as it resembled the histologically identical lesion in the main salivary glands.
  • The case is reported for its rarity and for the histological evaluation of the malignant potential in an apparently clinically benign neoplasm.
  • [MeSH-major] Carcinoma, Mucoepidermoid / diagnosis. Lung Neoplasms / diagnosis

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  • (PMID = 17883135.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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95. Palade R, Grigoriu M, Voiculescu D: [Gallbladder leiomyoma]. Chirurgia (Bucur); 2006 Jul-Aug;101(4):415-8
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  • [Transliterated title] Leiomiomul de veziculă biliară.
  • Leiomyoma, benign tumor generated by wall's smooth muscle proliferation, is extremely rare revealed.
  • The echographic exam may suggest sometimes the diagnosis but the presence of the stones makes it harder, especially when the bladder has scleroathrophic lesions.
  • The differential diagnosis with gallbladder carcinoma is necessary especially for medium dimensions tumors.
  • Laparoscopic cholecystectomy is the sufficient and recommended procedure; only even the benignity of the tumor is pathologically established.
  • [MeSH-major] Gallbladder Neoplasms. Leiomyoma
  • [MeSH-minor] Aged. Cholecystectomy, Laparoscopic. Diagnosis, Differential. Female. Humans. Treatment Outcome

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  • (PMID = 17059154.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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96. Lü BJ, Zhu J, Gao L, Xie L, Xu JY, Lai MD: [Diagnostic accuracy and pitfalls in fine needle aspiration cytology of salivary glands: a study of 113 cases]. Zhonghua Bing Li Xue Za Zhi; 2005 Nov;34(11):706-10
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  • RESULTS: The FNAC diagnostic failure (2); non-neoplastic lesions (12); benign neoplasm (82) and malignant neoplasm (17).
  • Cytologically, the distinction between cellular pleomorphic adenoma, adenoid cystic carcinoma and basal cell adenoma could be difficult due to their overlapping morphologic features.
  • The three inaccurately diagnosed cases of FNAC are, as follows: reactive lymphoid hyperplasia of lymph node mistaken as non-Hodgkin lymphoma, mucoepidermoid carcinoma diagnosed as "scanty atypical cells present" and primary lymphoepithelial carcinoma mistaken as benign lymphoepithelial lesion.
  • On the basis of FNAC, 97.4% (110 /113) were correctly depicted as benign (95/96; 99.0%) or malignant (15/17; 88.2%).
  • Furthermore, 90.3% (102 /113) (specificity = 91.9%; 102/111) were accurately diagnosed, including 91.7% (88/96) benign lesions (specificity = 92.6% ; 88/95) and 82.4% (14/17) malignant tumors (specificity = 87.5%; 14/16).
  • CONCLUSIONS: FNAC is reliable in distinguishing benign and malignant salivary gland lesions.
  • A specific cytologic diagnosis is often possible.
  • On the other hand, due to the pitfalls in cytologic diagnosis of certain salivary gland tumors, tissue biopsy for histologic examination may be necessary.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Carcinoma, Squamous Cell / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology
  • [MeSH-minor] Adenolymphoma / pathology. Adenoma / pathology. Adenoma, Pleomorphic / pathology. Adolescent. Adult. Aged. Biopsy, Fine-Needle. Carcinoma, Adenoid Cystic / pathology. Child. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Male. Middle Aged. Parotid Neoplasms / pathology. Retrospective Studies. Submandibular Gland Neoplasms / pathology

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  • (PMID = 16536312.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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97. Jansen AP, Camalier CE, Colburn NH: Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis. Cancer Res; 2005 Jul 15;65(14):6034-41
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  • To ascertain whether Pdcd4 suppresses tumor development in vivo, we have generated transgenic mice that overexpress Pdcd4 in the epidermis (K14-Pdcd4).
  • Expression of a protein encoded by 5' unstructured mRNA showed no change.
  • These results extend to an in vivo model the observations that Pdcd4 inhibits both translation initiation and AP-1 activation while decreasing benign tumor development and malignant progression.
  • [MeSH-major] Carcinoma, Squamous Cell / prevention & control. Papilloma / prevention & control. RNA-Binding Proteins / physiology. Skin Neoplasms / prevention & control
  • [MeSH-minor] 5' Untranslated Regions. Animals. Apoptosis Regulatory Proteins. Cytoplasm / metabolism. Disease Progression. Epidermis / metabolism. Epidermis / pathology. Female. Luciferases / antagonists & inhibitors. Luciferases / biosynthesis. Luciferases / genetics. Mice. Mice, Transgenic. Promoter Regions, Genetic. Protein Biosynthesis. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Transcription Factor AP-1 / antagonists & inhibitors. Transcription Factor AP-1 / physiology. Transcriptional Activation


98. van Buuren F, Langer C, Faber L, Butz T, Schmidt HK, Esdorn H, Bogunovic N, Mellwig KP, Scholtz W, Horstkotte D: Percutaneous balloon mitral valvulotomy and coexisting left atrial hemangioma: case report and long-term follow-up. Tex Heart Inst J; 2010;37(1):106-8
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  • The prognosis is quite variable, because this benign tumor may grow, involute, or stop growing; therefore, resection is usually the treatment of choice.
  • In patients with tumors of the left atrium, percutaneous balloon mitral valvulotomy is generally contraindicated.
  • Herein, we present the case of a 73-year-old woman who was referred to our department in 1995 with severe mitral valve stenosis.
  • There were no signs of coronary artery disease.
  • Magnetic resonance imaging and transesophageal echocardiography confirmed the diagnosis.

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99. Kuhne M, Boniquit N, Ghodadra N, Romeo AA, Provencher MT: The snapping scapula: diagnosis and treatment. Arthroscopy; 2009 Nov;25(11):1298-311
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  • [Title] The snapping scapula: diagnosis and treatment.
  • Understanding the anatomy of the scapula and surrounding neurovascular structures is crucial in making a differential diagnosis and providing both nonoperative and surgical treatments.
  • Common causes of snapping scapula include bursitis, muscle abnormality, and bony or soft-tissue abnormalities.
  • Benign tumor conditions of the scapula can also predispose one to snapping scapula syndrome and should be thoroughly investigated during the course of treatment.
  • [MeSH-major] Musculoskeletal Diseases / diagnosis. Scapula

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  • [CommentIn] Arthroscopy. 2010 Mar;26(3):299-300; author reply 301 [20206036.001]
  • (PMID = 19896053.001).
  • [ISSN] 1526-3231
  • [Journal-full-title] Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
  • [ISO-abbreviation] Arthroscopy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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100. Wu JK, Kitajewski JK: A potential role for notch signaling in the pathogenesis and regulation of hemangiomas. J Craniofac Surg; 2009 Mar;20 Suppl 1:698-702
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  • Hemangiomas are the most common benign tumor of infancy, yet its pathogenesis and the mechanisms governing proliferation and involution are not well understood.
  • Postnatally, it has been implicated in tumor angiogenesis in multiple malignancies.
  • Notch signaling triggers tumor angiogenesis at least in part to stimulation by VEGF, thus establishing that there is a cross talk between the VEGF and Notch pathways.
  • Given the presence of VEGF and its receptors in hemangiomas and known VEGF-Notch cross talk in tumor angiogenesis, the authors hypothesize that Notch signaling may contribute to hemangioma proliferation and involution.
  • [MeSH-major] Hemangioma / physiopathology. Receptors, Notch / physiology. Receptors, Vascular Endothelial Growth Factor / physiology. Signal Transduction / physiology. Skin Neoplasms / physiopathology

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  • (PMID = 19169152.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL062454
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Notch; EC 2.7.10.1 / Receptors, Vascular Endothelial Growth Factor
  • [Other-IDs] NLM/ NIHMS543366; NLM/ PMC3893793
  • [General-notes] NLM/ Original DateCompleted: 20090722
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