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1. Lasota J, Wang ZF, Sobin LH, Miettinen M: Gain-of-function PDGFRA mutations, earlier reported in gastrointestinal stromal tumors, are common in small intestinal inflammatory fibroid polyps. A study of 60 cases. Mod Pathol; 2009 Aug;22(8):1049-56
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gain-of-function PDGFRA mutations, earlier reported in gastrointestinal stromal tumors, are common in small intestinal inflammatory fibroid polyps. A study of 60 cases.
  • The inflammatory fibroid polyp is a rare benign lesion occurring throughout the digestive tract.
  • There were 26 deletions, three deletion-insertions, duplication, and single nucleotide substitution in exon 12, and a single nucleotide substitution and deletion in exon 18.
  • However, 1835_1852delinsCGC leading to the same S566_E571delinsR, were found in two tumors.
  • Similar gain-of-function PDGFRA mutations reported in gastrointestinal stromal tumors have been considered to be a driving pathogenetic force.
  • This study showed consistent expression and common mutational activation of PDGFRA in small intestinal inflammatory fibroid polyps as in their gastric counterparts, and these lesions should be considered PDGFRA-driven benign neoplasms.
  • [MeSH-major] Biomarkers, Tumor / genetics. Intestinal Neoplasms / genetics. Intestinal Polyps / genetics. Leiomyoma / genetics. Receptor, Platelet-Derived Growth Factor alpha / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. DNA Mutational Analysis. Female. Gastrointestinal Stromal Tumors / genetics. Humans. Immunohistochemistry. Intestine, Small / pathology. Male. Middle Aged. Mutation. Polymerase Chain Reaction. Young Adult

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  • (PMID = 19448595.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha
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2. Osaki T, Matsuura H: Thoracic empyema and lung abscess resulting from gastropulmonary fistula as a complication of esophagectomy. Ann Thorac Cardiovasc Surg; 2008 Jun;14(3):172-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A benign fistula between the gastric tube and the airway resulting from esophagectomy is a rare complication, but it is a potentially life-threatening status.
  • We present a 59-year-old man with thoracic empyema and lung abscess resulting from a benign gastric tube-to-pulmonary fistula caused by a penetration of the peptic ulcer in the gastric tube four years after an esophagectomy for esophageal cancer.
  • [MeSH-major] Empyema, Pleural / etiology. Esophageal Neoplasms / surgery. Esophagectomy / adverse effects. Gastric Fistula / complications. Lung Abscess / etiology. Respiratory Tract Fistula / complications
  • [MeSH-minor] Anti-Bacterial Agents / therapeutic use. Endoscopy, Gastrointestinal. Humans. Male. Middle Aged. Parenteral Nutrition. Thoracotomy. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18577896.001).
  • [ISSN] 1341-1098
  • [Journal-full-title] Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
  • [ISO-abbreviation] Ann Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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3. Kazakov DV, Grossmann P, Spagnolo DV, Vanecek T, Vazmitel M, Kacerovska D, Zelger B, Calonje E, Michal M: Expression of p53 and TP53 mutational analysis in malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome. Am J Dermatopathol; 2010 May;32(3):215-21
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  • [Title] Expression of p53 and TP53 mutational analysis in malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome.
  • We performed immunohistochemical assessment of p53 expression and TP53 mutational analysis of 15 malignant neoplasms arising from preexisting benign cylindroma, spiradenoma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome.
  • In one case only there were 2 p53 mutations, one being a c.673-1G>A splice-site mutation in the 3'-end of intron 6 (position--g.15289G>A, contig gb.AY838696.1) and the second being a c.743G>A (p.R248Q) mutation in exon 7 (position--15360G>A, contig gb.AY838696.1).
  • None of the 12 benign control group cases harbored a TP53 mutation, whereas all 12 demonstrated single nucleotide polymorphisms identical to those detected in the malignant tumor group.
  • In conclusion, we found a fairly high rate of p53 expression in malignant neoplasms arising from preexisting benign spiradenomas, cylindromas, and spiradenocylindromas.
  • Whereas immunostaining for p53 has been suggested as an adjunct tool to differentiate benign spiradenoma, cylindroma, and spiradenocylindroma from their malignant counterparts, its utility is limited by its heterogeneous pattern of expression, especially the sometimes lack of staining in clearly malignant areas and the occurrence of focal, weak positivity in the benign residua or in unequivocally benign neoplasms.
  • [MeSH-major] Adenoma / genetics. Carcinoma, Adenoid Cystic / genetics. Neoplasms, Multiple Primary / genetics. Point Mutation. Sweat Gland Neoplasms / genetics. Tumor Suppressor Protein p53 / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. DNA Mutational Analysis. DNA, Neoplasm / genetics. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Syndrome. Young Adult

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  • (PMID = 20075707.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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4. Yan JQ, Peng CH, Yang WP, Ding JZ, Zhou GW, Ma D, Li HW: Surgical management of benign duodenal tumours. ANZ J Surg; 2010 Jul-Aug;80(7-8):526-30
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  • [Title] Surgical management of benign duodenal tumours.
  • BACKGROUND: While benign duodenal tumours are rare compared with malignant tumours, they comprise a wide variety of pathologies.
  • Despite their diagnostic challenge, the optimal management of benign duodenal tumours remains undefined.
  • We aimed to review the diagnosis and surgical treatment of benign duodenal tumours.
  • METHODS: Records of all patients with post-operative pathological diagnosis of benign duodenal tumour were retrieved.
  • Information on clinical presentations, diagnostic methods, tumour locations, surgical approaches, pathological results and patient outcomes were analysed.
  • CONCLUSION: The presentation of benign duodenal tumours is non-specific, with upper abdominal discomfort and upper gastrointestinal bleeding as common symptoms.
  • [MeSH-major] Duodenal Neoplasms / pathology. Duodenal Neoplasms / surgery. Duodenum / surgery
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / pathology. Adenoma / surgery. Adult. Aged. Anastomosis, Surgical / methods. Biopsy, Needle. Cholangiopancreatography, Endoscopic Retrograde / methods. Cohort Studies. Colectomy / methods. Duodenoscopy / methods. Female. Follow-Up Studies. Hamartoma / diagnosis. Hamartoma / pathology. Hamartoma / surgery. Humans. Immunohistochemistry. Magnetic Resonance Imaging / methods. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Risk Assessment. Tomography, X-Ray Computed / methods. Treatment Outcome

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  • [CommentIn] ANZ J Surg. 2011 Apr;81(4):300-1 [21418483.001]
  • (PMID = 20795967.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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5. Gleeson FC, Clain JE, Papachristou GI, Rajan E, Topazian MD, Wang KK, Levy MJ: Prospective assessment of EUS criteria for lymphadenopathy associated with rectal cancer. Gastrointest Endosc; 2009 Apr;69(4):896-903
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: There are few data that assess the accuracy of echo characteristics for predicting lymph-node (LN) metastases in patients with rectal cancer.
  • MAIN OUTCOME MEASUREMENTS: Evaluation of perirectal nodal morphology accuracy that corresponds to malignant cytology and identification of echo criteria, including LN size, to have sufficient predictive value to predict malignancy.
  • RESULTS: Forty-three of 52 patients (83%) underwent FNA of a visualized LN.
  • The number of malignant nodal echo features per node did not distinguish benign from malignant pathology, except when all 4 features were present.
  • Only 68% of malignant LN had >or=3 echo characteristics.
  • An optimum LN short-axis or long-axis length cutoff value of 6 mm or 9 mm were 90% and 95% specific, respectively, for the presence of malignancy by receiver operating characteristic analysis.
  • LIMITATIONS: FNA was performed in a subset of identified LNs.
  • [MeSH-major] Endosonography. Rectal Neoplasms / pathology

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  • [CommentIn] Gastrointest Endosc. 2009 Apr;69(4):904-5 [19327476.001]
  • (PMID = 18718586.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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6. Nosrati N, Coleman NM, Hsu S: Axillary syringomas. Dermatol Online J; 2008;14(4):13
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  • Syringomas are common benign neoplasms encountered mostly around the eyes.
  • However, as described herein, these tumors can occur in atypical locations such as the axilla.
  • The differential diagnosis revolves around those entities more likely seen in this anatomical location (such as Fox-Fordyce, Hailey-Hailey and Darier diseases).
  • [MeSH-major] Sweat Gland Neoplasms / diagnosis. Syringoma / diagnosis
  • [MeSH-minor] Adult. Axilla / pathology. Diagnosis, Differential. Female. Humans. Sex Factors. Skin / pathology

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  • (PMID = 18627735.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Moraitis D, Singh P, Jayadevan R, Cayten CG: Colonic wall thickening on computed tomography scan and clinical correlation. Does it suggest the presence of an underlying neoplasia? Am Surg; 2006 Mar;72(3):269-71
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  • [Title] Colonic wall thickening on computed tomography scan and clinical correlation. Does it suggest the presence of an underlying neoplasia?
  • The purpose of our study was to determine the incidence of significant clinical pathology and, particularly, neoplasia in patients with abnormally thickened bowel on CT scan examination.
  • Thirty-five patients had no history of previous gastrointestinal disorder and form our study group.
  • Eight (23%) patients with thick bowel had colonic neoplasia based on pathology.
  • Four (11%) of the 5 patients with colon adenocarcinoma did not have any associated gastrointestinal symptoms or signs.
  • One (3%) patient had lymphoma of the colon and two (6%) had benign polyps.
  • [MeSH-major] Colon / radiography. Colonic Neoplasms / radiography. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Colitis / diagnosis. Colonoscopy. Diagnosis, Differential. Female. Humans. Incidence. Male. Middle Aged. Reproducibility of Results. Retrospective Studies. Severity of Illness Index

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  • (PMID = 16553131.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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8. Dunst CM, Swanström LL: Minimally invasive esophagectomy. J Gastrointest Surg; 2010 Feb;14 Suppl 1:S108-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The procedural goal is to decrease the high overall morbidity of a traditional open esophageal resection.
  • The entire spectrum of open esophagectomy techniques has been successfully replicated in a minimally invasive fashion.
  • Minimally invasive approaches show most promise for benign disease and select early esophageal cancers, but their role in more advanced cancer remains controversial due to lack of long-term results.
  • CONCLUSION: As minimally invasive esophagectomy matures, its true value in both benign and malignant disorders will become better defined.
  • [MeSH-minor] Esophageal Neoplasms / surgery. Humans

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  • (PMID = 19789930.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Petrolla AA, Xin W: Hepatic angiomyolipoma. Arch Pathol Lab Med; 2008 Oct;132(10):1679-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Hepatic angiomyolipoma is a rare, benign, hepatic mesenchymal neoplasm found in both males and females, and most commonly in adult females.
  • The liver represents the second most frequent site of involvement.
  • The smooth muscle cell component is the most specific to the diagnosis.
  • The differential diagnosis includes hepatocellular carcinoma, hepatic adenoma, leiomyoma, hepatoblastoma, melanoma, and gastrointestinal stromal tumor.
  • The immunohistochemical staining pattern differentiates this lesion from other malignant and benign liver lesions.
  • If the diagnosis of hepatic angiomyolipoma has been made, it can be followed conservatively or surgically resected.
  • [MeSH-major] Angiomyolipoma / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Antigens, Neoplasm / metabolism. Female. Humans. MART-1 Antigen. Male. Melanoma-Specific Antigens. Neoplasm Proteins / metabolism. S100 Proteins / metabolism

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  • (PMID = 18834230.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins
  • [Number-of-references] 17
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10. Xing BC, Sun Y, Bao Q, Qian HG, Hao CY, Huang XF, Wang Y, Gu J, Ji JF: [Spleen-preserving distal pancreatectomy in treatment of solid-pseudopapillary neoplasm]. Zhonghua Yi Xue Za Zhi; 2006 Mar 14;86(10):690-2
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  • [Title] [Spleen-preserving distal pancreatectomy in treatment of solid-pseudopapillary neoplasm].
  • OBJECTIVE: To investigate the feasibility and safety of spleen-preserving distal pancreatectomy with conservation of the splenic arteries and veins in treatment of benign neoplasms of distal pancreas.
  • METHODS: Four patients with solid-pseudopapillary neoplasm, 1 males and 3 females, aged 30 (17 - 37), underwent laparotomy.
  • The distal pancreas with tumor was cut.
  • CONCLUSION: Safe and feasible, spleen-preserving distal pancreatectomy with conservation of the splenic arteries and veins is one of the best choices for treatment of benign and borderline tumors of pancreas.
  • [MeSH-major] Carcinoma, Papillary / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery

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  • (PMID = 16681929.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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11. Hassounah M, Lach B, Allam A, Al-Khalaf H, Siddiqui Y, Pangue-Cruz N, Al-Omeir A, Al-Ahdal MN, Aboussekhra A: Benign tumors from the human nervous system express high levels of survivin and are resistant to spontaneous and radiation-induced apoptosis. J Neurooncol; 2005 May;72(3):203-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign tumors from the human nervous system express high levels of survivin and are resistant to spontaneous and radiation-induced apoptosis.
  • Here we have assessed the level of the survivin protein in some benign tumors of the nervous system: meningioma, schwannoma, low-grade ependymoma, pilocytic astrocytoma and pituitary adenoma.
  • Using immuno-blot analysis we present evidence that these low-grade tumors are positive for survivin expression.
  • In agreement, flow cytometrical analysis showed that both spontaneous and radiation-induced apoptosis levels are very low in these neoplasms.
  • Using host cell reactivation assay we have also shown that these tumor cells are proficient in the repair of gamma-ray-induced DNA damage.
  • These results suggest that survivin overexpression may be an early event in the stepwise tumoregenesis and hence could be responsible for the onset as well as the growth advantage during tumoregenic progression of malignant as well as benign neoplasms.
  • [MeSH-major] Apoptosis / physiology. Apoptosis / radiation effects. Microtubule-Associated Proteins / biosynthesis. Nervous System Neoplasms / metabolism. Nervous System Neoplasms / pathology
  • [MeSH-minor] Cell Line, Tumor. DNA Damage / radiation effects. Electrophoresis, Polyacrylamide Gel. Flow Cytometry. Gamma Rays. Genes, p53 / genetics. Genes, p53 / radiation effects. Humans. Immunoblotting. Inhibitor of Apoptosis Proteins. Neoplasm Proteins / metabolism. Oncogene Protein p21(ras) / biosynthesis. Oncogene Protein p21(ras) / radiation effects. Tumor Cells, Cultured. Ultraviolet Rays

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  • (PMID = 15937641.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; EC 3.6.5.2 / Oncogene Protein p21(ras)
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12. Shi RL, Li JF, Qu Y, Chen XH, Gu QL, Zhu ZG, Liu BY: [Expression of Ezrin in gastric carcinoma and its significance]. Zhonghua Wei Chang Wai Ke Za Zhi; 2006 Sep;9(5):433-5
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  • OBJECTIVE: To investigate the expression of Ezrin in gastric cancer, its role in tumor metastasis.
  • METHODS: Ezrin expression in tumor tissues from 90 gastric cancer cases and in normal gastric mucosa from 12 cases with benign disease was examined by immunohistochemical staining.
  • [MeSH-major] Cytoskeletal Proteins / metabolism. Stomach Neoplasms / metabolism. Stomach Neoplasms / pathology
  • [MeSH-minor] Cell Line, Tumor. Female. Gene Expression. Humans. Lymphatic Metastasis. Male. Neoplasm Invasiveness. Neoplasm Staging. Protein Array Analysis

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  • (PMID = 17043968.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cytoskeletal Proteins; 0 / ezrin
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13. You YN, Leibovitch BC, Que FG: Hepatic metastasectomy for testicular germ cell tumors: is it worth it? J Gastrointest Surg; 2009 Apr;13(4):595-601
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  • [Title] Hepatic metastasectomy for testicular germ cell tumors: is it worth it?
  • BACKGROUND: Chemotherapy is highly effective for metastatic germ cell tumor (GCT), but experience with resection of hepatic metastases from GCT is limited.
  • Hepatic histology included: necrosis (33%), viable tumor (27%), mature teratoma (13%), and benign histology (27%).
  • Concomitant resection of extrahepatic disease (14 patients, 93%) found necrosis (53%), mature teratoma (27%), and viable tumor (13%).
  • At 8.2 years (mean) from resection, 11 patients (73%) were alive: five with no evidence of disease, two with elevated tumor marker only, and four with gross disease.
  • The 10-year overall survival was 62% from diagnosis.
  • [MeSH-major] Hepatectomy. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Neoplasms, Germ Cell and Embryonal / secondary
  • [MeSH-minor] Adolescent. Adult. Choriocarcinoma / secondary. Choriocarcinoma / surgery. Female. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Survival Analysis. Testicular Neoplasms / pathology. Young Adult

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  • [ISSN] 1873-4626
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  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
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14. Ritter MR, Reinisch J, Friedlander SF, Friedlander M: Myeloid cells in infantile hemangioma. Am J Pathol; 2006 Feb;168(2):621-8
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  • Little is known about the pathogenesis of infantile hemangiomas despite the fact that they are relatively common tumors.
  • These benign neoplasms occur in as many as 1 in 10 births, and although rarely life threatening, hemangiomas can pose serious concerns to the cosmetic and psychosocial development of the afflicted child.

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  • (PMID = 16436675.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / F32 EY013916; United States / NEI NIH HHS / EY / R01 EY011254; United States / NEI NIH HHS / EY / F32 EY13916; United States / NEI NIH HHS / EY / R01 EY11254
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD14; 0 / Antigens, CD15; 0 / CD83 antigen; 0 / Immunoglobulins; 0 / Membrane Glycoproteins; 0 / Receptors, IgG
  • [Other-IDs] NLM/ PMC1606494
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15. Gamblin TC, Krasinskas AM, Slivka AS, Tublin ME, Demetris J, Shue E, Caro S, Marsh JW, James Moser A: Fibroinflammatory biliary stricture: a rare bile duct lesion masquerading as cholangiocarcinoma. J Gastrointest Surg; 2009 Apr;13(4):713-21
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  • INTRODUCTION: Fibroinflammatory biliary stricture (FIBS) is a rare benign tumor-like process of the extrahepatic bile duct that masquerades as cholangiocarcinoma.
  • Preoperative evaluation included computed tomography scan and endoscopic retrograde cholangiopancreatography with benign brush cytology.
  • RESULTS AND DISCUSSION: Immunohistochemistry demonstrated smooth muscle actin expression in all lesions except one; five tumors exhibited IgG4 positive plasma cells.
  • CONCLUSION: FIBS is a rare myofibroblastic lesion with an immunohistochemical profile distinct from other epithelial and stromal neoplasms of the extrahepatic bile duct.
  • Because preoperative cytology is not diagnostic of FIBS, surgical resection remains the mainstay of diagnosis and treatment, while immunosuppression may reduce the risk of recurrence.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Bile Ducts, Extrahepatic / pathology. Bile Ducts, Intrahepatic. Cholangiocarcinoma / diagnosis

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  • (PMID = 19057967.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK-51485; United States / NICHD NIH HHS / HD / K12 HD 049109
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins
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16. Bellolio J E, Guzmán G P, Orellana C J, Roa S JC, Villaseca H M, Araya O JC, Tapia E O, Ineda N V: [Diagnostic value of frozen section biopsy during surgery for breast lesions or neoplasms]. Rev Med Chil; 2009 Sep;137(9):1173-8
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  • [Title] [Diagnostic value of frozen section biopsy during surgery for breast lesions or neoplasms].
  • [Transliterated title] Validez diagnóstica de la biopsia intraoperatoria en cirugía de lesiones mamarias palpables.
  • BACKGROUND: During the surgical treatment of breast neoplasms (benign or malignant), frozen section biopsy is frequently requested to assess the kind of lesion and determine the surgical margins.
  • MATERIAL AND METHODS: AH the pathological reports of frozen section biopsies and definitive biopsies of 337 women aged 26 to 88 years, operated for suspected breast neoplasms between 2002 and 2006, were reviewed.
  • The diagnosis of phyllodes tumor was missed by frozen section biopsy in three cases.
  • [MeSH-major] Biopsy / methods. Breast Neoplasms / pathology. Frozen Sections / standards. Intraoperative Care / methods

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  • (PMID = 20011957.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Chile
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17. Schmitz-Feuerhake I, Pflugbeil S, Pflugbeil C: [Radiation risks from diagnostic radiology: meningiomas and other late effects after exposure of the skull]. Gesundheitswesen; 2010 Apr;72(4):246-54
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  • [Title] [Radiation risks from diagnostic radiology: meningiomas and other late effects after exposure of the skull].
  • [Transliterated title] Röntgenrisiko: Abschätzung der strahleninduzierten Meningeome und anderer Spätschäden bei Exposition des Schädels.
  • A complete assessment of late effects of X-ray diagnostics should take into account that radiation sensitivity varies considerably for the different ages at exposure and, furthermore, that not only malignant diseases but also benign neoplasms are induced which also may lead to severe detriment of the patient.
  • Dose-effect relationships for tumours of the brain, skin, thyroid, and other sites of the head region, leukaemia, and cataracts are taken from the literature.
  • 1,000 annual paediatric CT investigations of the skull will lead to about 3 excess neoplasms in the head region, i.e., the probability of an induced late effect must be suspected in the range of some thousandths.
  • The radiation-induced occurrence of meningiomas and other brain tumours most probably contributes to the continuously increasing incidence of these diseases which is observed in several industrial nations, as well as the exposure of the bone marrow by CT to the increase of childhood leukaemia.
  • [MeSH-major] Brain Neoplasms / etiology. Brain Neoplasms / radiography. Meningeal Neoplasms / etiology. Meningioma / etiology. Neoplasms, Radiation-Induced / etiology. Skull / radiation effects. Tomography, X-Ray Computed / adverse effects

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  • [Copyright] Georg Thieme Verlag KG Stuttgart, New York.
  • (PMID = 19551621.001).
  • [ISSN] 1439-4421
  • [Journal-full-title] Gesundheitswesen (Bundesverband der Ärzte des Öffentlichen Gesundheitsdienstes (Germany))
  • [ISO-abbreviation] Gesundheitswesen
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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18. Joyner DE, Wade ML, Szabo A, Bastar J, Coffin CM, Albritton KH, Bernard PS, Randall RL: Discriminate gene lists derived from cDNA microarray profiles of limited samples permit distinguishing mesenchymal neoplasia ex vivo. J Cancer Res Clin Oncol; 2005 Mar;131(3):137-46
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  • [Title] Discriminate gene lists derived from cDNA microarray profiles of limited samples permit distinguishing mesenchymal neoplasia ex vivo.
  • BACKGROUND: Mesenchymal neoplasia comprises a heterogeneous group of tumors with over 200 benign neoplasms and 100 sarcomas.
  • Currently, tumors are classified using histologic and immunocytologic characteristics, with diagnostic error rates reported as high as 40% of cases.
  • As a feasibility study, our goal was to generate a preliminary discriminatory gene list for selected mesenchymal tumors, including sarcomas.
  • This technique may enable an eventual molecular classification schema based on expression profiles that can complement current clinical and pathologic diagnostic procedures in mesenchymal tumors.
  • METHODS: cDNA microarray analyses were preformed on connective tissue tumors obtained at time of surgical resection or biopsy.
  • Messenger RNA (mRNA) from four general tumor classes was competitively hybridized against a human dermal fibroblast cell line comparator and the resulting gene expression profiles processed by ANOVA and linear discriminate analysis.
  • RESULTS: The tissue classification involved 18 patients with malignant peripheral nerve sheath tumors, giant cell containing tumors, benign spindle cell lesions, or Ewing's family of tumors.
  • CONCLUSIONS: Linear discriminate analysis of cDNA gene expression profiles partitioned mesenchymal tumor classes, even when constrained by limited sample sizes.
  • [MeSH-major] DNA Fingerprinting. DNA, Neoplasm / analysis. Mesenchymoma / diagnosis. Mesenchymoma / genetics. Neoplasms, Connective Tissue / diagnosis. Neoplasms, Connective Tissue / genetics. Oligonucleotide Array Sequence Analysis
  • [MeSH-minor] Analysis of Variance. Carcinoma / diagnosis. Carcinoma / genetics. Carcinoma, Giant Cell / diagnosis. Carcinoma, Giant Cell / genetics. Cell Line. Feasibility Studies. Fibroblasts. Gene Expression Regulation, Neoplastic. Humans. Linear Models. Nerve Sheath Neoplasms / diagnosis. Nerve Sheath Neoplasms / genetics. RNA, Messenger / analysis. RNA, Neoplasm / analysis. Sarcoma, Ewing / diagnosis. Sarcoma, Ewing / genetics. Skin / cytology

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  • (PMID = 15614524.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / RNA, Messenger; 0 / RNA, Neoplasm
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19. Cavaliere R, Lopes MB, Schiff D: Low-grade gliomas: an update on pathology and therapy. Lancet Neurol; 2005 Nov;4(11):760-70
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  • Low-grade gliomas (LGG) are not benign neoplasms.
  • [MeSH-major] Brain Neoplasms / pathology. Brain Neoplasms / therapy. Glioma / pathology. Glioma / therapy

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  • (PMID = 16239183.001).
  • [ISSN] 1474-4422
  • [Journal-full-title] The Lancet. Neurology
  • [ISO-abbreviation] Lancet Neurol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 119
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20. Buragas M, Kidd M, Modlin IM, Cha C: Multiple gastrointestinal stromal tumors and synchronous ileal carcinoids. Nat Clin Pract Oncol; 2005 Mar;2(3):166-70; quiz 1 p following 170
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  • [Title] Multiple gastrointestinal stromal tumors and synchronous ileal carcinoids.
  • His physical examination and medical history were unremarkable except for benign prostatic hypertrophy.
  • Biopsy of the mass revealed an ulcerated tumor composed of spindle cells.
  • A gastric-wedge resection revealed an ulcerated 4.5 cm mass in the stomach, and exploration of the abdomen revealed two ileal carcinoid tumors, jejunal diverticula and reactive mesenteric lymphadenopathy.
  • DIAGNOSIS: Multiple gastrointestinal stromal tumors occurring concomitantly with ileal carcinoids.
  • [MeSH-major] Carcinoid Tumor / pathology. Ileal Neoplasms / pathology. Neoplasms, Multiple Primary. Neoplasms, Second Primary
  • [MeSH-minor] Aged. Diverticulum / etiology. Gastrointestinal Stromal Tumors. Hematemesis / etiology. Humans. Immunohistochemistry. Jejunal Diseases / etiology. Male. Stomach Ulcer / etiology


21. Levy AD, Shaw JC, Sobin LH: Secondary tumors and tumorlike lesions of the peritoneal cavity: imaging features with pathologic correlation. Radiographics; 2009 Mar-Apr;29(2):347-73
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  • [Title] Secondary tumors and tumorlike lesions of the peritoneal cavity: imaging features with pathologic correlation.
  • Tumors and tumorlike lesions that secondarily involve the mesothelial or submesothelial layers of the peritoneum are a diverse group of disorders that range in biologic behavior from benign to highly malignant.
  • Peritoneal carcinomatosis is the most common secondary tumor to affect the peritoneal cavity.
  • When it arises from carcinomas of the gastrointestinal tract or ovary, the prognosis is grave.
  • Granulomatous peritonitis is the consequence of disseminated infection such as tuberculosis or histoplasmosis, foreign materials, or rupture of a tumor or hollow viscus.
  • Finally, a group of benign miscellaneous conditions that range from common disorders such as endometriosis and splenosis to very rare conditions such as gliomatosis peritonei and melanosis may also affect the peritoneum diffusely.
  • Secondary tumors and tumorlike lesions of the peritoneum have overlapping imaging features when compared with each other and primary peritoneal tumors.
  • [MeSH-major] Neoplasms, Mesothelial / diagnosis. Neoplasms, Mesothelial / secondary. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / secondary. Tomography, X-Ray Computed / methods. Ultrasonography / methods

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  • (PMID = 19325052.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 93
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22. Varghese LR, Stanley MW, Wakely PE Jr, Lucido ML, Mallery S, Bardales RH: A case report of anthracosilicotic spindle-cell pseudotumor of mediastinal lymph node: cytologic diagnosis by endoscopic ultrasound-guided fine-needle aspiration. Diagn Cytopathol; 2005 Oct;33(4):268-72
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  • [Title] A case report of anthracosilicotic spindle-cell pseudotumor of mediastinal lymph node: cytologic diagnosis by endoscopic ultrasound-guided fine-needle aspiration.
  • Pigmented spindle-cell tumors of the lymph nodes have a broad differential diagnosis, including both benign and malignant neoplasms.
  • Here, we report a case of a pigmented spindle-cell lesion in a mediastinal lymph node mimicking a spindle-cell melanoma on fine-needle aspiration cytology.
  • Electron microscopy was confirmatory and a diagnosis of anthracosilicotic spindle-cell pseudotumor was made.
  • [MeSH-minor] Aged. Biopsy, Fine-Needle. Diagnosis, Differential. Endoscopy, Gastrointestinal. Humans. Male. Mediastinal Neoplasms / diagnosis. Mediastinum. Melanoma / diagnosis. Microscopy, Polarization / methods. Pneumoconiosis / complications. Pneumoconiosis / pathology. Silicon Dioxide / analysis. Ultrasonography

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc
  • (PMID = 16138379.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 7631-86-9 / Silicon Dioxide
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23. Ducic Y, Oxford L, Pontius AT: Transoral approach to the superomedial parapharyngeal space. Otolaryngol Head Neck Surg; 2006 Mar;134(3):466-70
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  • OBJECTIVES: To present our early experience with the transoral approach to the superomedial parapharyngeal space (PPS) and describe our technique for removal of these neoplasms.
  • METHODS: Eight patients with various neoplasms of the superomedial PPS were retrospectively reviewed for type of neoplasm, size, success with the transoral approach, need for conversion to another approach, length of hospitalization, and complications.
  • RESULTS: The transoral approach described herein safely allowed for en bloc resection of benign neoplasms with intraoperative control and exposure of the internal carotid artery.
  • Mean tumor size was 3.3 cm (range, 1.5 to 7 cm).
  • This technique is indicated for neoplasms with benign appearance on preoperative imaging or fine needle aspiration.
  • [MeSH-major] Mouth / surgery. Pharyngeal Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Biopsy, Needle. Carotid Artery, Internal / pathology. Child. Female. Follow-Up Studies. Humans. Intraoperative Care. Length of Stay. Male. Middle Aged. Neoplasm Invasiveness. Neurilemmoma / pathology. Neurilemmoma / surgery. Postoperative Complications. Retrospective Studies. Teratoma / pathology. Teratoma / surgery. Treatment Outcome

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  • (PMID = 16500446.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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24. de Toro C G, Villaseca H M, Roa S JC: [Colitis cystica profunda: report of one case]. Rev Med Chil; 2007 Jun;135(6):759-63
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  • Colitis cystica profunda is a benign condition that can be confused with adenocarcinoma.
  • After this period she presented again intermittent hematochezia and a rectal mass that was surgically removed.
  • [MeSH-minor] Adult. Carcinoma / radiotherapy. Female. Gastrointestinal Hemorrhage / etiology. Humans. Necrosis. Ulcer / complications. Uterine Cervical Neoplasms / radiotherapy

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  • (PMID = 17728902.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Chile
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25. Linder JD, Geenen JE, Catalano MF: Cyst fluid analysis obtained by EUS-guided FNA in the evaluation of discrete cystic neoplasms of the pancreas: a prospective single-center experience. Gastrointest Endosc; 2006 Nov;64(5):697-702
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  • [Title] Cyst fluid analysis obtained by EUS-guided FNA in the evaluation of discrete cystic neoplasms of the pancreas: a prospective single-center experience.
  • BACKGROUND: Accurate assessment of pancreatic cystic neoplasms is imperative before selecting available treatment options, such as surgical resection, drainage, or conservative therapy.
  • Available modalities, CT and magnetic resonance imaging, have been inconsistent in diagnosis.
  • Reports involving EUS and cyst fluid analysis have been encouraging, including studies of EUS features and/or cyst fluid analysis, which may differentiate pancreatic cystic neoplasms.
  • OBJECTIVE: To retrospectively determine cyst fluid characteristics that differentiate cystic neoplasms.
  • Exclusion criteria included the following: intraductal papillary mucinous tumor lesions, bloody cyst aspirate, neuroendocrine tumors, and patients without surgical histopathology.
  • PATIENTS: A total of 102 patients (60 women, 42 men; age, 23-76 years) presented for evaluation of pancreatic cystic neoplasm; 71 underwent surgical resection.
  • All mucinous neoplasms had VIS >1.6, whereas only 2 mucinous cystic neoplasms (MCN) had VIS = 1.6 (both PC).
  • Amylase levels were higher in PC (7210 U/L) compared with cystic neoplasm (SCyA, 679 U/L; MCyA, 1605 U/L; MCyA-CA, 569 U/L).
  • CONCLUSIONS: Differential diagnosis of pancreatic cystic neoplasm is significantly enhanced by cyst fluid analysis.
  • Malignant from benign MCN can be differentiated by CEA levels > or =6000 ng/mL.
  • [MeSH-major] Biomarkers, Tumor / analysis. Biopsy, Fine-Needle / methods. Cyst Fluid / chemistry. Endosonography. Pancreatic Neoplasms / chemistry. Pancreatic Pseudocyst / chemistry

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  • [CommentIn] Gastrointest Endosc. 2006 Nov;64(5):703-4 [17055860.001]
  • (PMID = 17055859.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen; 0 / Mucins; EC 3.1.1.3 / Lipase; EC 3.2.1.- / Amylases
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26. McLoughlin MT, Byrne MF: Endoscopic stenting: where are we now and where can we go? World J Gastroenterol; 2008 Jun 28;14(24):3798-803
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  • Self expanding metal stents (SEMS) play an important role in the management of malignant obstructing lesions in the gastrointestinal tract.
  • The development of the polyflex stent, which is a removable self expanding plastic stent, allows temporary stent insertion for benign esophageal disease and possibly for patients undergoing neoadjuvant chemotherapy prior to esophagectomy.
  • Potential complications of SEMS insertion include perforation, tumour overgrowth or ingrowth, and stent migration.
  • Other areas of development include biodegradable stents for benign disease and radioactive or drug-eluting stents for malignant disease.
  • [MeSH-major] Endoscopy, Gastrointestinal / trends. Stents / trends
  • [MeSH-minor] Colonic Neoplasms / surgery. Esophageal Neoplasms / surgery. Gastrointestinal Neoplasms / surgery. Humans. Intestinal Obstruction / surgery

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  • (PMID = 18609702.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2721435
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27. Masoud N, Manouchehr K, Najmeh D, Monireh H: Lack of association between Helicobacter pylori and laryngeal carcinoma. Asian Pac J Cancer Prev; 2008 Jan-Mar;9(1):81-2
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  • SUBJECTS: Patients with laryngeal cancer as cases and patients with benign laryngeal lesion as controls.
  • RESULTS: Totally, 44 patients (42 men and 2 women) with squamous cell carcinoma of larynx and 30 patients (24 men and 6 women) with benign laryngeal lesions (polyp, nodule, granuloma) were studied, none of which were infected with the bacterium.
  • Pylori infection among patients with laryngeal cancer (SCC) or benign laryngeal lesions. .
  • [MeSH-major] Carcinoma, Squamous Cell / microbiology. Helicobacter Infections / microbiology. Helicobacter pylori / isolation & purification. Laryngeal Neoplasms / microbiology

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  • (PMID = 18439080.001).
  • [ISSN] 2476-762X
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] EC 3.5.1.5 / Urease
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28. Benarroch-Gampel J, Riall TS: Extrapancreatic malignancies and intraductal papillary mucinous neoplasms of the pancreas. World J Gastrointest Surg; 2010 Oct 27;2(10):363-7
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  • [Title] Extrapancreatic malignancies and intraductal papillary mucinous neoplasms of the pancreas.
  • Over the last two decades multiple studies have demonstrated an increased incidence of additional malignancies in patients with intraductal papillary mucinous neoplasms (IPMNs).
  • The majority of these additional cancers occur before or concurrent with the diagnosis of IPMN.
  • The gastrointestinal tract is most commonly involved in secondary malignancies, with benign colon polyps and colon cancer commonly seen in western countries and gastric cancer commonly seen in Asian countries.
  • Other extrapancreatic malignancies associated with IPMNs include benign and malignant esophageal neoplasms, gastrointestinal stromal tumors, carcinoid tumors, hepatobiliary cancers, breast cancers, prostate cancers, and lung cancers.
  • If a patient has not had recent colonoscopy, this should be performed during the evaluation of a newly diagnosed IPMN.
  • Upper endoscopy should be performed in patients from Asian countries or for those who present with symptoms suggestive of upper gastrointestinal disease.
  • Routine screening studies (breast and prostate) should be carried out as currently recommended for patient's age both before and after the diagnosis of IPMN.

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  • (PMID = 21160845.001).
  • [ISSN] 1948-9366
  • [Journal-full-title] World journal of gastrointestinal surgery
  • [ISO-abbreviation] World J Gastrointest Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2999205
  • [Keywords] NOTNLM ; Intraductal papillary mucinous neoplasm / Invasive / Malignant potential / Non-invasive / Secondary malignancy
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29. Biswas D, Crank S: Aetiopathology of maxillary swelling--a 3-year prospective study. Eur Arch Otorhinolaryngol; 2007 Nov;264(11):1295-9
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  • A wide variety of lesions and not necessarily a malignant tumour can cause maxillary swelling.
  • Non-specificity of clinical and radiological features of these maxillary lesions makes their diagnosis difficult.
  • The awareness of the spectrum of pathology related to maxillary swelling is essential for correct diagnosis and treatment.
  • Maxillary swelling was found to be caused by malignant tumours in 54.2%, benign neoplasms in 22.9% and non-neoplastic lesions in 22.9%.
  • Overall squamous cell carcinoma (22.9%) was the commonest lesion, tumour of vascular origin was the commonest benign neoplasm and odontogenic cyst was the commonest among the non-neoplastic lesions.

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  • (PMID = 17611767.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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30. Gómez-Martín C, Rodríguez A, Malón D, Cortés-Funes H: Biliary cystadenocarcinoma with mesenchymal stroma. Clin Transl Oncol; 2010 Mar;12(3):234-7
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  • This tumour needs to be distinguished from benign biliary cystadenoma, which is antecedent in most cases.
  • Preoperative diagnosis of BCACs is often difficult, because their clinical manifestations are similar to those of other hepatic cystic lesions.
  • [MeSH-major] Biliary Tract Neoplasms / pathology. Cystadenocarcinoma / pathology. Mesoderm / pathology. Neoplasms, Second Primary / pathology
  • [MeSH-minor] Adenocarcinoma, Papillary / pathology. Adult. Antineoplastic Agents / therapeutic use. Chemotherapy, Adjuvant. Female. Hepatectomy. Hepatitis B / complications. Humans. Thyroid Neoplasms / pathology

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  • (PMID = 20231130.001).
  • [ISSN] 1699-3055
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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31. Sawhney MS, Debold SM, Kratzke RA, Lederle FA, Nelson DB, Kelly RF: Central intranodal blood vessel: a new EUS sign described in mediastinal lymph nodes. Gastrointest Endosc; 2007 Apr;65(4):602-8
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  • In malignant nodes, this pattern is distorted because of tumor infiltration and neovascularization.
  • OBJECTIVE: To determine whether EUS imaging of central intranodal blood vessels (CIV) can be used to differentiate benign from malignant subcarinal lymph nodes in lung cancer.
  • The diagnostic accuracy of CIV was compared with other lymph-node features in a retrospective cohort of patients who underwent EUS for lung cancer evaluation.
  • Findings were then prospectively validated in a similar cohort.
  • PATIENTS: Patients who underwent EUS for lung cancer diagnosis or staging at the VA Medical Center from March 2003 to March 2005.
  • RESULTS: Of 67 patients included in the retrospective analysis, CIV was noted in 17 of 35 patients with benign nodes (49%), compared with 5 of 32 patients with malignant nodes (16%) (P = .002).
  • In lymph nodes > or =1 cm, CIV was noted in 14 of 16 patients with benign nodes (88%), compared with 2 of 27 with malignant nodes (7%) (P < .001).
  • CONCLUSIONS: The absence of a central intranodal blood vessel was a strong and independent predictor of malignancy in lymph nodes of patients with lung cancer and can be used to select lymph nodes for FNA.
  • [MeSH-major] Endosonography / methods. Lung Neoplasms / pathology. Lymph Nodes / blood supply. Lymph Nodes / ultrasonography. Lymphatic Metastasis / ultrasonography

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  • (PMID = 17383457.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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32. Kluger N, Perrochia H, Guillot B: Pelvic mass in von Recklinghausen's neurofibromatosis: diagnostic issues: a case report. Cases J; 2009;2:191
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  • BACKGROUND: Leiomyomas are benign smooth muscle cell tumours.
  • They are the most common uterine neoplasms, although they may also occur elsewhere, such as in the gastrointestinal and urinary tracts.
  • CASE REPORT: We report here the unusual case of a 47-year-old woman with NF1 who presented menorrhagias and a hard, tender pelvic mass composed of uterine leiomyomas.
  • Abdominal hysterectomy was performed and microscopic examination confirmed the diagnosis of multiple benign smooth muscle tumours (uterine leiomyomatosis).

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  • (PMID = 19946501.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2783146
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33. Beltran MA, Cruces KS: Primary tumors of jejunum and ileum as a cause of intestinal obstruction: a case control study. Int J Surg; 2007 Jun;5(3):183-91
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  • [Title] Primary tumors of jejunum and ileum as a cause of intestinal obstruction: a case control study.
  • BACKGROUND: Small-bowel tumors are rare and account for 1-2% of all gastrointestinal neoplasms.
  • Most of these tumors are found at surgery indicated for other diagnosis or intestinal obstruction.
  • The rarity, unclear presentation and diagnostic difficulty of these tumors stimulated our interest to review our experience with emergency surgery for intestinal obstruction secondary to jejunoileal tumors.
  • METHODS: We reviewed 17 patients operated on for intestinal obstruction secondary to benign and malignant primary tumors of jejunum and ileum at our institution the last 10 years.
  • The most frequent tumors found were GIST (36%) followed by lymphomas (24%) and adenocarcinomas (18%).
  • Most tumors (65%) were located in the ileum.
  • Mean survival for patients with malignant tumors was 19.5+/-13 months, and for patients with benign tumors 72+/-20 months (p<0.05).
  • CONCLUSION: Jejunoileal tumors present frequently in patients younger than 49 years of age.
  • Ileal tumors are more likely to develop intestinal obstruction than jejunal tumors.
  • [MeSH-major] Ileal Neoplasms / complications. Intestinal Obstruction / etiology. Jejunal Neoplasms / complications
  • [MeSH-minor] Abdomen, Acute / etiology. Adenocarcinoma / complications. Adult. Aged. Case-Control Studies. Female. Gastrointestinal Stromal Tumors / complications. Gastrointestinal Stromal Tumors / pathology. Humans. Leiomyoma / complications. Logistic Models. Lymphoma / complications. Lymphoma / pathology. Male. Middle Aged. Neoplasm Staging. Sarcoma / complications

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  • (PMID = 17509501.001).
  • [ISSN] 1743-9159
  • [Journal-full-title] International journal of surgery (London, England)
  • [ISO-abbreviation] Int J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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34. Usunova I, Vladimirov V: [Benign neoplasms of female urethra]. Akush Ginekol (Sofiia); 2009;48(1):31-3
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  • [Title] [Benign neoplasms of female urethra].
  • In clinical practice neoplasms of female urethra are found usually in adult women.
  • Histological sample analysis has provided diagnosis of urethral polyp, caruncle and mucosal prolaps.
  • Collaboration between urologists and gynecologists is essential for early diagnosis, prophylaxis and successful treatment of above mentioned diseases.
  • [MeSH-major] Urethral Neoplasms / diagnosis. Urethral Neoplasms / surgery

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  • (PMID = 19496462.001).
  • [ISSN] 0324-0959
  • [Journal-full-title] Akusherstvo i ginekologii︠a︡
  • [ISO-abbreviation] Akush Ginekol (Sofiia)
  • [Language] bul
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Bulgaria
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35. Pironi D, Vendettuoli M, La Gioia G, Arcieri S, Filippini A: A large Brunner's gland adenoma: an unusual cause of gastrointestinal bleeding. Case report and literature review. Ann Ital Chir; 2010 Mar-Apr;81(2):147-51
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  • [Title] A large Brunner's gland adenoma: an unusual cause of gastrointestinal bleeding. Case report and literature review.
  • Brunner's gland adenoma is a rare benign tumour of the duodenum.
  • It is usually small and asymptomatic often discovered incidentally with upper gastrointestinal endoscopy, but sometimes may become large causing symptoms (haemorrhage or intestinal obstruction).
  • We report a rare case of a very large Brunner's gland adenoma in a 38-year-old female presenting with severe anaemia but without obstructive symptoms and detected by ultrasonography.
  • The tumour was managed by surgical removal and during a six month follow-up the patient remained symptom-free without any recurrence.
  • [MeSH-major] Adenoma / complications. Brunner Glands. Duodenal Neoplasms / complications. Gastrointestinal Hemorrhage / etiology

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  • (PMID = 20726394.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 45
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36. Val-Bernal JF, Mayorga M, Diego C, González-Vela MC: Pedunculated polypoid lymphangioma of the anal canal. Pathol Int; 2008 Jul;58(7):442-4
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  • Lymphangioma is a rare benign lesion of the gastrointestinal tract, in which the large intestine is the least commonly involved site.
  • Described herein is a case of pedunculated polypoid lymphangioma of the right lateral wall on the transitional zone of the anal canal measuring 1.7 x 1.3 x 1 cm in a 40-year-old woman.
  • A pedicle does not exclude the endoscopic diagnosis of lymphangioma.
  • Lymphangioma must be included in the differential diagnosis of polypoid lesions of the anal canal.
  • [MeSH-major] Anus Neoplasms / pathology. Lymphangioma / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Rectal Fistula / pathology

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  • (PMID = 18577114.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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37. Nagula S, Kennedy T, Schattner MA, Brennan MF, Gerdes H, Markowitz AJ, Tang L, Allen PJ: Evaluation of cyst fluid CEA analysis in the diagnosis of mucinous cysts of the pancreas. J Gastrointest Surg; 2010 Dec;14(12):1997-2003
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  • [Title] Evaluation of cyst fluid CEA analysis in the diagnosis of mucinous cysts of the pancreas.
  • BACKGROUND: Although cyst fluid carcinoembryonic antigen (CEA; > 192 ng/ml) is the preferred test for identifying mucinous pancreatic cysts, the data are more robust for mucinous cystic neoplasms (MCN) than for intraductal papillary mucinous neoplasms (IPMN).
  • RESULTS: Two hundred sixty-seven patients were identified; pathological diagnosis was obtained in 97.
  • Mucinous cysts were identified in 66 of 97 (68%): benign IPMN, n = 42; malignant IPMN, n = 10; benign MCN, n = 12; malignant MCN, n = 2.
  • One hundred seventy-eight patients were managed with an initial non-operative strategy.
  • Eight (4%) developed radiographic changes necessitating surgery; pathology demonstrated seven benign mucinous cysts and one retention cyst.
  • [MeSH-major] Carcinoembryonic Antigen / analysis. Cyst Fluid / chemistry. Pancreatic Cyst / diagnosis

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  • (PMID = 20658204.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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38. Ioncica AM, Malos A, Crisan E, Popescu C, Saftoiu A, Ciurea T: State-of-the art endoscopic imaging in lung cancer: should specialties collide or concur? J Gastrointestin Liver Dis; 2010 Mar;19(1):93-7
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  • Transesophageal endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) represents a method which not only allows the visualization of the upper gastrointestinal tract, but also offers good visualisation of the posterior and inferior mediastinum.
  • Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) permits the assessment of the tumors in the anterior mediastinum.
  • Based on previously published literature, it is obvious that this minimally invasive procedure now offers the possibility of tissue diagnosis in mediastinal masses including primary tumours or secondary lesions from both benign and malignant diseases.
  • [MeSH-major] Biopsy, Fine-Needle. Bronchoscopy. Echocardiography, Transesophageal. Endosonography. Lung Neoplasms / diagnosis. Ultrasonography, Interventional
  • [MeSH-minor] Diagnosis, Differential. Humans. Neoplasm Staging. Predictive Value of Tests

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  • (PMID = 20361084.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Romania
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39. Wilhelm SM, Robinson AV, Krishnamurthi SS, Reynolds HL: Evaluation and management of incidental thyroid nodules in patients with another primary malignancy. Surgery; 2007 Oct;142(4):581-6; discussion 586-7
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  • We sought to determine the rate of malignancy in incidental thyroid nodules in patients with other malignancies, and examine the accuracy of ultrasound (US) versus computed tomography (CT) in determining nodule size.
  • METHODS: We evaluated 41 patients with history of another known malignancy (gastrointestinal, 23; breast, 11; other, 7) referred with an incidental thyroid nodule.
  • Pathology yielded 4 papillary thyroid cancers (PTC), 4 microPTC, 2 metastatic cancers, and 7 benign lesions.
  • [MeSH-major] Carcinoma, Papillary / epidemiology. Carcinoma, Papillary / surgery. Thyroid Neoplasms / epidemiology. Thyroid Neoplasms / surgery. Thyroid Nodule / epidemiology. Thyroid Nodule / surgery
  • [MeSH-minor] Bile Duct Neoplasms / epidemiology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic. Biopsy. Carcinoma, Renal Cell / epidemiology. Carcinoma, Renal Cell / secondary. Cholangiocarcinoma / epidemiology. Cholangiocarcinoma / secondary. Databases, Factual. Humans. Incidence. Kidney Neoplasms / epidemiology. Kidney Neoplasms / pathology. Melanoma / epidemiology. Melanoma / secondary. Skin Neoplasms / epidemiology. Skin Neoplasms / pathology. Tomography, X-Ray Computed. Ultrasonography


40. Razzak R, Bédard EL, Hunt I, Satkunam N: Spindle cell lipoma of the esophagus. Eur J Cardiothorac Surg; 2009 Mar;35(3):542-3
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  • Esophageal lipomas are benign tumors representing less than 0.5% of all gastrointestinal lipomas.
  • We describe a case of a 60-year-old man with progressive dysphagia and weight loss, who presented with several episodes of near asphyxiation secondary to regurgitation and aspiration of the pedunculated mass.
  • [MeSH-major] Asphyxia / etiology. Esophageal Neoplasms / pathology. Lipoma / pathology

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  • (PMID = 19195907.001).
  • [ISSN] 1873-734X
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
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41. Chatelain D, Brevet M, Fuks D, Yzet T, Verhaeghe P, Regimbeau JM, Lauwers G, Sevestre H: [Inflammatory fibroid polyp, a rare tumor of the appendix]. Gastroenterol Clin Biol; 2008 Mar;32(3):274-7
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  • [Title] [Inflammatory fibroid polyp, a rare tumor of the appendix].
  • [Transliterated title] Le polype fibroïde inflammatoire, une tumeur rare de l'appendice.
  • The lesion was diagnosed in a 33-year-old woman presenting with abdominal pain, fever and localized tenderness in right iliac fossa on abdominal palpation.
  • CT-scan showed an 8 cm appendiceal mass and a laparoscopic appendectomy was consequently performed.
  • On microscopic examination, the tumor consisted of spindle cells dispersed in a loose fibromyxoid stroma containing numerous blood cells and inflammatory cells with abundant eosinophils.
  • On immunohistochemistry, the spindle tumor cells were positive for vimentin, fascin and focally for CD34 and CD35.
  • Inflammatory fibroid polyp is a rare benign mesenchymal tumor of the gastrointestinal tract rarely reported in the appendix.
  • This tumor shares some common pathologic features with the myofibroblatic inflammatory tumor but they are two different entities.
  • The pathogenesis of this tumor remains unclear but fascin and CD35 immunoreactivity of the tumor cells suggests a probable dendritic cell origin.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Intestinal Polyps / pathology. Leiomyoma / pathology

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  • (PMID = 18353580.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / CR1 protein, human; 0 / Carrier Proteins; 0 / Microfilament Proteins; 0 / Receptors, Complement 3b; 0 / Vimentin; 146808-54-0 / fascin
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42. Chekrine T, Tawfiq N, Bourhaleb Z, Benchakroun N, Jouhadi H, Sahraoui S, Benider A: [Giant-cell bone tumors of the spine: report of two cases and literature review]. Cancer Radiother; 2009 Sep;13(5):451-4
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  • [Title] [Giant-cell bone tumors of the spine: report of two cases and literature review].
  • [Transliterated title] Deux cas de tumeurs osseuses à cellules géantes du rachis et revue de la littérature.
  • Giant cell tumours (GCT) are relatively rare neoplasms, most often benign.
  • We report two observations of GCT, the spine in a 51-year-old woman and a 14-year-old boy.
  • Computed tomography and magnetic resonance imaging showed osteolysis of the body and vertebral arch of L5 for the first and a process affecting the vertebral body and medullary canal of T6-T7 with spinal cord compression for the second case.
  • The diagnosis was confirmed by histological examination in two cases.
  • [MeSH-major] Giant Cell Tumor of Bone / radiotherapy. Spinal Neoplasms / radiotherapy

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  • (PMID = 19615930.001).
  • [ISSN] 1769-6658
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 15
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43. Tsimmerman IaS: [Neuroendocrine tumours of pancreas and gastrointestinal tract]. Klin Med (Mosk); 2009;87(12):7-13
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  • [Title] [Neuroendocrine tumours of pancreas and gastrointestinal tract].
  • This paper reviews data on benign and malignant neuroendocrine tumours of pancreas and gastrointestinal tract including insulinoma, glucagonoma, somatostatinoma, gastrinoma, carcinoid syndrome, and multiple endocrine neoplasms.
  • Their origin, prevalence, clinical manifestations, laboratory and instrumental diagnosis, surgical and medicamentous treatment are discussed.
  • [MeSH-major] Gastrointestinal Neoplasms. Neuroendocrine Tumors. Pancreatic Neoplasms
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Diagnosis, Differential. Diagnostic Imaging. Digestive System Surgical Procedures / methods. Humans. Prevalence. Russia / epidemiology

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  • (PMID = 20135878.001).
  • [ISSN] 0023-2149
  • [Journal-full-title] Klinicheskaia meditsina
  • [ISO-abbreviation] Klin Med (Mosk)
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 39
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44. Nikolić M, Boban M, Ljubicić N, Duvnjak M, Hrabar D, Pavić T: [Evaluation of upper gastrointestinal submucosal lesions by endoscopic ultrasonography]. Acta Med Croatica; 2009 Dec;63 Suppl 3:29-37
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  • [Title] [Evaluation of upper gastrointestinal submucosal lesions by endoscopic ultrasonography].
  • Endoscopy is an established method for diagnosing gastrointestinal tract diseases, however, suspected subepithelial lesions usually cannot be appropriately evaluated by this technique alone.
  • In this review, we evaluated the role of endoscopic ultrasonography (EUS) in the diagnosis of and management strategy for submucosal lesions.
  • EUS has emerged as the most reliable investigative procedure of choice for evaluating submucosal tumors.
  • EUS is the method of choice to differentiate between true intramural tumors and lesions caused by extraluminal compressions due to normal or pathologic structures.
  • Some endoscopic findings (color, consistency, mobility, 'pillow sign') can be helpful in narrowing the differential diagnosis.
  • On the other hand, determination of the histologic layer and the internal echo patterns of some submucosal tumors are also predictive of benign or malignant tumors.
  • EUS can provide an accurate diagnosis in 80% of patients with benign lesions and 64% of those with malignant lesions.
  • [MeSH-major] Endosonography. Gastrointestinal Diseases / ultrasonography. Upper Gastrointestinal Tract / ultrasonography
  • [MeSH-minor] Gastrointestinal Neoplasms / ultrasonography. Humans

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  • (PMID = 20232668.001).
  • [ISSN] 1330-0164
  • [Journal-full-title] Acta medica Croatica : c̆asopis Hravatske akademije medicinskih znanosti
  • [ISO-abbreviation] Acta Med Croatica
  • [Language] hrv
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Croatia
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45. King JC, Ng TT, White SC, Cortina G, Reber HA, Hines OJ: Pancreatic serous cystadenocarcinoma: a case report and review of the literature. J Gastrointest Surg; 2009 Oct;13(10):1864-8
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  • BACKGROUND: Serous cystic neoplasms of the pancreas are benign lesions with little chance for malignant degeneration.
  • The mean age at diagnosis is 68 +/- 2 years (range, 52 to 81), and women are affected more commonly (2:1).
  • CONCLUSIONS: We conclude that there is a small but finite risk of malignancy for serous cystic neoplasms of the pancreas.
  • [MeSH-major] Cystadenocarcinoma, Serous / diagnosis. Pancreatic Neoplasms / diagnosis

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  • (PMID = 19459016.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
  • [Other-IDs] NLM/ PMC2759006
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46. Lee HW, Lee JJ, Yang DH, Lee BH: A clinicopathologic study of glomus tumor of the stomach. J Clin Gastroenterol; 2006 Sep;40(8):717-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A clinicopathologic study of glomus tumor of the stomach.
  • Glomus tumors are benign lesions and originate from modified smooth muscle cells of the glomus body.
  • These tumors are commonly observed in the dermis or subcutis, but only rarely found in the stomach.
  • Here we report a case of a 67-year-old patient in whom glomus tumor of the stomach was diagnosed after 10-day history of melena.
  • We have reviewed the 13 cases selected from literature of gastric glomus tumor in Korean, including our case.
  • The tumors typically presented with gastrointestinal bleeding or ulcerlike symptom, and 6 tumors had mucosal ulceration.
  • The tumor sizes varied from 1.2 to 3.8 cm (median 2.5 cm), and all tumors presented in antrum of stomach.
  • Microscopically, the tumors were well-circumscribed, and composed of uniform, small, round to polygonal cells.
  • The characteristics of gastric glomus tumors in Korean patients are very similar to those of Western populations.
  • Although gastric glomus tumors can be considered more likely benign, a small possibility of malignant behavior cannot be ruled out.
  • [MeSH-major] Glomus Tumor. Stomach Neoplasms

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  • (PMID = 16940885.001).
  • [ISSN] 0192-0790
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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47. Bogliolo G, Martino G, Di Fulvio A, Tonda M, Pontone P: [Endoscopic endoprosthesis insertion in the treatment of digestive diseases]. G Chir; 2006 May;27(5):217-22
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  • [Title] [Endoscopic endoprosthesis insertion in the treatment of digestive diseases].
  • [Transliterated title] L'utilizzo delle protesi endoscopiche nella patologia dell'apparato digerente.
  • Over the last few years the use of endoscopically placed endoprostheses for benign and malignant digestive diseases has considerably developed.
  • This study presents a review of experience with prostheses placement in digestive diseases.
  • [MeSH-major] Digestive System Diseases / surgery. Endoscopy, Digestive System. Prosthesis Implantation. Stents
  • [MeSH-minor] Cholangitis, Sclerosing / surgery. Cholestasis / surgery. Colonic Neoplasms / complications. Constriction, Pathologic. Deglutition Disorders / etiology. Endoscopy, Gastrointestinal. Esophageal Stenosis / complications. Esophageal Stenosis / surgery. Esophagoscopy. Humans. Intestinal Obstruction / etiology. Intestinal Obstruction / surgery. Jaundice, Obstructive / surgery. Metals. Palliative Care. Pancreatitis / surgery. Prospective Studies. Randomized Controlled Trials as Topic. Recurrence

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  • (PMID = 16857111.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Metals
  • [Number-of-references] 28
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48. Landi B, Palazzo L: The role of endosonography in submucosal tumours. Best Pract Res Clin Gastroenterol; 2009;23(5):679-701
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Submucosal tumours (SMTs) are relatively common findings in patients undergoing endoscopy, especially in upper gastrointestinal (GI) tract.
  • This term includes various non-neoplastic and neoplastic conditions.
  • In this review, the following issues will be addressed: the endosonographic features of SMT; the diagnostic accuracy of EUS; the ability of EUS to distinguish benign and malignant SMTs; the value of EUS-guided fine-needle aspiration (FNA); and the influence of EUS on clinical management.
  • [MeSH-major] Endoscopy, Gastrointestinal. Endosonography. Gastrointestinal Neoplasms / ultrasonography
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Gastrointestinal Stromal Tumors / ultrasonography. Humans. Mucous Membrane / ultrasonography. Neoplasm Staging. Predictive Value of Tests

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  • (PMID = 19744633.001).
  • [ISSN] 1532-1916
  • [Journal-full-title] Best practice & research. Clinical gastroenterology
  • [ISO-abbreviation] Best Pract Res Clin Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 33
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49. Odell DD, Pratt WB, Callery MP, Vollmer CM Jr: The obstructed pancreatico-biliary drainage limb: presentation, management, and outcomes. J Gastrointest Surg; 2010 Sep;14(9):1414-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Individuals with PB limb obstruction were identified from a cohort of 477 patients undergoing major PB resections or bypasses for benign and malignant (N = 265) diseases from September 2000 to January 2010.
  • The other two are alive at a mean follow-up of 48 months.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Drainage / adverse effects. Pancreatic Neoplasms / surgery. Postoperative Complications / etiology. Reoperation / methods

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  • (PMID = 20567929.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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50. Lasota J, vel Dobosz AJ, Wasag B, Wozniak A, Kraszewska E, Michej W, Ptaszynski K, Rutkowski P, Sarlomo-Rikala M, Steigen SE, Schneider-Stock R, Stachura J, Chosia M, Ogun G, Ruka W, Siedlecki JA, Miettinen M: Presence of homozygous KIT exon 11 mutations is strongly associated with malignant clinical behavior in gastrointestinal stromal tumors. Lab Invest; 2007 Oct;87(10):1029-41
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  • [Title] Presence of homozygous KIT exon 11 mutations is strongly associated with malignant clinical behavior in gastrointestinal stromal tumors.
  • Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of gastrointestinal tract.
  • GISTs range from benign indolent neoplasms to highly malignant sarcomas.
  • In this study, we report 36 GIST patients whose tumors had homozygous KIT exon 11 mutations detected by direct sequencing of PCR products.
  • Loss of heterozygosity in KIT locus and other chromosome 4 loci were documented in majority of these tumors.
  • However, fluorescence in situ hybridization with KIT locus-specific probe and chromosome 4 centromeric enumeration probe showed no evidence of KIT hemizygosity in a majority of analyzed cases.
  • Homozygous KIT exon 11 mutations were found in 33 primary tumors and 7 metastatic lesions.
  • In two cases, shift from heterozygosity to homozygosity was documented during tumor progression being present in metastases, but not in primary tumors.
  • An average primary tumor size was 12 cm and average mitotic activity 32/50 HPFs.
  • Out of 32 tumors 29 (90.6%) with complete clinicopathologic data were diagnosed as sarcomas with more than 50% risk of metastatic disease, and 26 of 29 patients with follow-up had metastases or died of disease.
  • [MeSH-major] Gastrointestinal Stromal Tumors / genetics. Loss of Heterozygosity. Neoplasm Metastasis / genetics. Proto-Oncogene Proteins c-kit / genetics

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  • [CommentIn] Lab Invest. 2008 May;88(5):456-7 [18432212.001]
  • (PMID = 17632543.001).
  • [ISSN] 0023-6837
  • [Journal-full-title] Laboratory investigation; a journal of technical methods and pathology
  • [ISO-abbreviation] Lab. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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51. Munir N, Bradley PJ: Diagnosis and management of neoplastic lesions of the submandibular triangle. Oral Oncol; 2008 Mar;44(3):251-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis and management of neoplastic lesions of the submandibular triangle.
  • Review of submandibular triangle neoplasms (benign and malignant) treated at a tertiary referral centre in the United Kingdom (1986-2004).
  • Forty nine benign and 58 malignant neoplasms of the submandibular triangle were reviewed.
  • Definitive diagnosis was by excision and pathological examination.
  • Pleomorphic adenoma (n=37) were the most common benign neoplasms.
  • The most frequent primary lesions were malignant non-Hodgkin lymphoma (n=22), adenoid cystic carcinoma (n=9) and mucoepidermoid carcinoma (n=9).
  • The mainstay treatment for both benign and malignant lesions was surgical either by extracapsular excision of the gland/lesion or selective levels I, IIa and III neck dissection.
  • Submandibular triangle neoplasms are rare and pose many diagnostic and therapeutic challenges.
  • There is a relatively high incidence of malignant neoplasms in this region (54%).
  • Benign tumours manifest a mild course of disease and have an excellent prognosis following adequate excision.
  • Malignant tumours have a poor symptomatology that can result in late (often post-operative) diagnosis.
  • The adequacy of primary surgery is crucial and would support the approach of a more radical excision primarily with a selective levels I, IIa and III neck dissection; ensuring a definitive operation for benign lesions, avoiding the risks of tumour spillage associated with a more limited excision; and removing the primary echelon of lymph nodes at risk of metastasis if the pathology in fact turns out to be malignant; without a significantly higher morbidity in comparison with an extracapsular gland/lesion excision.
  • [MeSH-major] Mouth Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / surgery. Child. Female. Humans. Lymphoma, Non-Hodgkin / diagnosis. Lymphoma, Non-Hodgkin / surgery. Male. Middle Aged. Retrospective Studies. Submandibular Gland Neoplasms / diagnosis. Submandibular Gland Neoplasms / surgery. Treatment Outcome

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  • (PMID = 17467329.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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52. Jhala NC, Eltoum IA, Eloubeidi MA, Meara R, Chhieng DC, Crowe DR, Jhala D: Providing on-site diagnosis of malignancy on endoscopic-ultrasound-guided fine-needle aspirates: should it be done? Ann Diagn Pathol; 2007 Jun;11(3):176-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Providing on-site diagnosis of malignancy on endoscopic-ultrasound-guided fine-needle aspirates: should it be done?
  • BACKGROUND: Rapid and accurate tissue diagnosis for a deep-seated malignancy would allow treating physicians to provide disease-specific interventions and help patients make early informed management decisions.
  • Providing on-site tissue diagnosis for fine-needle aspirate samples obtained with endosonography would help develop such efficient patient management issues.
  • Here we report our experience of prospectively providing on-site diagnosis on 485 endoscopic ultrasound fine-needle aspirate samples.
  • METHODS: Four hundred eighty-five endoscopic ultrasound fine-needle aspirates from the pancreas (n= 305), lymph nodes (n = 91), biliary tree (n = 47), liver (n = 15), gastrointestinal tract (n = 19), and adrenal gland (n = 8) were reviewed.
  • RESULTS: Of the 485 cases, 163 (33.6%) were diagnosed as benign, 43 (8.8%) as atypical, 21 (4.3%) as suspicious, 18 (3.7%) as positive for neoplasm, and 230 (47.4%) as malignant after final cytologic interpretation.
  • A significantly (P < .001) higher degree of concordance was noted for unequivocal diagnosis of malignancy (196/198, 98.9%) vs nonmalignancy (200/250, 67.2%) between on-site and final cytologic diagnosis.
  • Of the 52 discordant cases, 12 (2.6%) diagnoses were downgraded and 40 (8.9%) were upgraded from preliminary on-site diagnosis.
  • Our overall sensitivity (87 vs 92), specificity (95% vs 100%), and accuracy (90% vs 94%) improved for final cytologic diagnosis.
  • CONCLUSION: On-site diagnosis of malignancy could be used to initiate informed patient management decisions.
  • Cases where a diagnosis of malignancy is not rendered at on-site interpretation need further cytologic evaluation.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Endosonography / methods. Neoplasms / diagnosis
  • [MeSH-minor] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / pathology. Adult. Aged. Aged, 80 and over. Gastrointestinal Neoplasms / diagnosis. Gastrointestinal Neoplasms / pathology. Humans. Liver Neoplasms / diagnosis. Liver Neoplasms / pathology. Middle Aged. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / pathology. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 17498591.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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53. Dorić M, Radović S, Babić M, Hukić A, Kuskunović S, Tomić I, Selak I: Testicular metastasis of gastrointestinal stromal tumor of the jejunum. Bosn J Basic Med Sci; 2007 May;7(2):176-9
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  • [Title] Testicular metastasis of gastrointestinal stromal tumor of the jejunum.
  • Gastrointestinal stromal tumors (GIST) are neoplasm of mesenchymal origin that usually begins in cells of the wall of the gastrointestinal tract.
  • It can be benign or malignant.
  • In this report, we have presented a case of malignant GIST with uncommon site of metastasis.

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  • (PMID = 17489757.001).
  • [ISSN] 1512-8601
  • [Journal-full-title] Bosnian journal of basic medical sciences
  • [ISO-abbreviation] Bosn J Basic Med Sci
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Bosnia and Herzegovina
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54. Yu DC, Javid PJ, Chikwava KR, Kozakewich HP, Debiec-Rychter M, Lillehei CW, Weldon CB: Mesenteric lipoblastoma presenting as a segmental volvulus. J Pediatr Surg; 2009 Feb;44(2):e25-8
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  • Mesenteric lipoblastoma is a rare tumor and, its presentation as a bowel obstruction with possible midgut volvulus has only been reported once before.
  • A 7-year-old girl presented with nausea and vomiting but a benign abdominal examination.
  • Upper gastrointestinal contrast study demonstrated possible malrotation with midgut volvulus.
  • Resection margins were negative for tumor, and the patient is doing well with no evidence of recurrence.
  • [MeSH-major] Intestinal Obstruction / etiology. Intestinal Volvulus / etiology. Intestine, Small. Mesentery. Peritoneal Neoplasms / complications

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  • (PMID = 19231517.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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55. Zhou JP, Yang ZL, Liu DC, Zhou JP: [Expression of galectin 3 and Sambucus nigra agglutinin and their clinicopathological significance in benign and malignant lesions of stomach]. Zhonghua Wei Chang Wai Ke Za Zhi; 2009 May;12(3):297-300
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  • [Title] [Expression of galectin 3 and Sambucus nigra agglutinin and their clinicopathological significance in benign and malignant lesions of stomach].
  • OBJECTIVE: To study the expressive levels of galectin-3(gal-3) and Sambucus nigra agglutinin(SNA) and their clinicopathological significance in the benign and malignant lesions of stomach.
  • METHODS: EnVision immunohistochemistry for assaying gal-3 expressive level and ABC cytochemistry for determining SNA expressive level were used in conventional paraffin-embedded sections from specimens of gastric cancer(n=49), peritumoral tissues(n=20), metastatic foci of lymph nodes(n=36), and different types of benign lesions(n=80).
  • RESULTS: The positive rates of gal-3 and SNA were significantly higher in gastric cancer tissues than those in peritumoral tissues and different types of benign lesions(P<0.05, P<0.01).
  • The positive cases of gal-3 and/or SNA in peritumoral tissues and benign lesions showed mild- to severe-atypical hyperplasia of mucous epithelial cells.
  • The positive rates of gal-3 and SNA were higher in lymphnode metastatic site N1 and no-metastasis of distant organs than those in lymphnode metastatic site N2,N3 and metastasis of distant organs, but no significant difference was found(P>0.05).
  • [MeSH-major] Galectin 3 / metabolism. Plant Lectins / metabolism. Ribosome Inactivating Proteins / metabolism. Stomach Neoplasms / metabolism. Stomach Neoplasms / pathology
  • [MeSH-minor] Adenoma / pathology. Adult. Aged. Female. Gastritis / pathology. Humans. Immunohistochemistry. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Polyps / pathology

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  • (PMID = 19434543.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Galectin 3; 0 / Plant Lectins; 0 / Sambucus nigra lectins; EC 3.2.2.22 / Ribosome Inactivating Proteins
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56. Capovilla M, Couturier J, Molinié V, Bruneval P, Vieillefond A: [Juxtaglomerular cell tumors: report of two cases with genomic analysis]. Ann Pathol; 2008 Oct;28(5):474-6
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  • [Title] [Juxtaglomerular cell tumors: report of two cases with genomic analysis].
  • [Transliterated title] Tumeur à rénine du rein : à propos de deux cas, avec analyse génomique.
  • Juxtaglomerular-cell tumor (JGCT), first described in 1967, is a rare tumor of the kidney that derives from specialized smooth-muscle cells of the wall of the glomerular afferent arteriole.
  • JGCTs are considered benign, but the clinical follow-up has been short in most reported cases.
  • Only one metastatic case has been reported to date, raising the question of tumors of uncertain malignant potential rather than clearly benign neoplasms.
  • Similarly to the two previously reported cases, these two tumors showed losses on chromosomes 9 and 11, suggesting recurrent chromosomal imbalances.
  • Thus, JGCT might be better considered as a tumor of uncertain malignant potential consequently requiring a prolonged follow-up.
  • [MeSH-major] Juxtaglomerular Apparatus / pathology. Kidney Cortex / pathology. Kidney Neoplasms / pathology

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  • (PMID = 19068398.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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57. Bisdas S, Baghi M, Wagenblast J, Knecht R, Thng CH, Koh TS, Vogl TJ: Differentiation of benign and malignant parotid tumors using deconvolution-based perfusion CT imaging: feasibility of the method and initial results. Eur J Radiol; 2007 Nov;64(2):258-65
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  • [Title] Differentiation of benign and malignant parotid tumors using deconvolution-based perfusion CT imaging: feasibility of the method and initial results.
  • AIM: We evaluated the feasibility of perfusion CT (CTP) of the parotid gland and attempted to differentiate benign from malignant tumors.
  • MATERIALS AND METHODS: CTP was performed in 17 patients with benign tumors and 10 patients with malignant parotid tumors.
  • Regions of interest were placed through the tumor site and the contralateral healthy parotid tissue.
  • Ratios of the perfusion values between the tumors and the contralateral healthy structures were also calculated.
  • RESULTS: Perfusion maps of all tumors were successfully obtained.
  • High Pearson correlation coefficients comparing the two readers' visually measured abnormalities were observed (r=0.79-0.86, P=0.001) for all perfusion maps, The MTT and PS values between malignant and benign tumors were not significantly different.
  • The BF and BV values were statistically significant different between the benign and malignant tumors (0.00<P<0.02).
  • Only the BV ratio criterion between malignant and benign neoplasms was statistically significant (P<0.004).
  • CONCLUSIONS: CTP of the parotid gland is feasible and may differentiate malignant from non-malignant lesions by means of absolute BF, BV and BV ratio values.
  • [MeSH-major] Image Processing, Computer-Assisted / methods. Parotid Neoplasms / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adenocarcinoma / radiography. Adenolymphoma / radiography. Adenoma, Pleomorphic / radiography. Aged. Blood Volume / physiology. Capillary Permeability / physiology. Carcinoma, Adenoid Cystic / radiography. Contrast Media. Diagnosis, Differential. Feasibility Studies. Female. Humans. Iopamidol / analogs & derivatives. Male. Middle Aged. Parotid Gland / blood supply. Parotid Gland / radiography. Radiographic Image Enhancement / methods. Regional Blood Flow / physiology. Time Factors

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  • (PMID = 17399933.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media; 17E17JBP8L / iomeprol; JR13W81H44 / Iopamidol
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58. Kozarek RA: Transpapillary cytology analysis helps to distinguish benign from malignant gallbladder disease. Should we do it? Gastrointest Endosc; 2006 Oct;64(4):520-1
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  • [Title] Transpapillary cytology analysis helps to distinguish benign from malignant gallbladder disease. Should we do it?
  • [MeSH-major] Bile / cytology. Catheters, Indwelling. Drainage / instrumentation. Duodenoscopes. Gallbladder Diseases / diagnosis. Gallbladder Neoplasms / diagnosis. Sphincterotomy, Endoscopic / instrumentation
  • [MeSH-minor] Cholangiopancreatography, Endoscopic Retrograde. Diagnosis, Differential. Gallbladder / pathology. Humans. Sensitivity and Specificity. Tomography, X-Ray Computed

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  • [CommentOn] Gastrointest Endosc. 2006 Oct;64(4):512-9 [16996341.001]
  • (PMID = 16996342.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] United States
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59. Radecke K, Gerken G, Treichel U: Impact of a self-expanding, plastic esophageal stent on various esophageal stenoses, fistulas, and leakages: a single-center experience in 39 patients. Gastrointest Endosc; 2005 Jun;61(7):812-8
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  • [Title] Impact of a self-expanding, plastic esophageal stent on various esophageal stenoses, fistulas, and leakages: a single-center experience in 39 patients.
  • BACKGROUND: In this study, we describe our experience with the use of a self-expanding, covered, plastic esophageal stent (SEPS).
  • METHODS: Thirty-nine patients were treated by insertion of a SEPS by endoscopic or radiologic guidance for the following: malignant stenosis (n = 22), malignant fistula (n = 8), benign stenosis after treatment for malignant disease (n = 6), benign fistula (n = 2), and perforation or leakage after surgery of the esophagus (n = 5).
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anastomosis, Surgical / adverse effects. Device Removal. Esophageal Neoplasms / complications. Esophagoscopy. Female. Follow-Up Studies. Foreign-Body Migration / etiology. Humans. Male. Middle Aged. Plastics. Postoperative Complications. Prosthesis Design. Radiography, Interventional. Recurrence. Retrospective Studies. Treatment Outcome

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  • (PMID = 15933681.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Plastics
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60. Yates CW, Weinberg M, Packer MJ, Jacob A: Fatal case of tumor-associated hemorrhage in a large vestibular schwannoma. Ann Otol Rhinol Laryngol; 2010 Jun;119(6):402-5
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  • [Title] Fatal case of tumor-associated hemorrhage in a large vestibular schwannoma.
  • Vestibular schwannomas are benign neoplasms that arise from Schwann cells of the eighth cranial nerve.
  • We report the case of a 69-year-old man with a large vestibular schwannoma who required anticoagulation for several medical comorbidities.
  • Attempts were made to stabilize the patient, including posterior fossa craniectomy and evacuation of hematoma; however, the intracranial hemorrhage ultimately resulted in a fatal outcome.
  • During this procedure, a biopsy specimen was obtained, showing benign vestibular schwannoma.

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  • (PMID = 20583739.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticoagulants; 5Q7ZVV76EI / Warfarin
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61. Pasieka JL: Carcinoid tumors. Surg Clin North Am; 2009 Oct;89(5):1123-37
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  • [Title] Carcinoid tumors.
  • Carcinoid tumors, which arise from the enterochromaffin cells of the gastrointestinal tract, encompass a diverse group of neoplasms.
  • Once thought to be "carcinoma-like," these neoplasms exhibit a biologic behavior that varies from an indolent, benign course to an aggressive, rapidly progressive, and deadly disease.
  • Today the term carcinoid is reserved for neuroendocrine tumors arising from the small bowel or neuroendocrine tumors that can cause carcinoid syndrome.
  • For the general surgeon there are several "carcinoid" tumors that he or she must be familiar with because many of these lesions are encountered during emergency laparotomies or incidentally discovered during investigation for vague abdominal pain.
  • This review focuses on the gastrointestinal neuroendocrine tumors that general surgeons are likely to encounter during their career.
  • [MeSH-major] Carcinoid Tumor / surgery. Gastrointestinal Neoplasms / surgery. Neuroendocrine Tumors / surgery

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  • (PMID = 19836488.001).
  • [ISSN] 1558-3171
  • [Journal-full-title] The Surgical clinics of North America
  • [ISO-abbreviation] Surg. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 54
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62. Hu ZM, Zou SC, Zhao DJ, Zhang CW, Shi D, Ye ZY, Jiang YP: [Diagnosis and treatment of benign duodenal tumor]. Zhonghua Wei Chang Wai Ke Za Zhi; 2005 Jan;8(1):35-7
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  • [Title] [Diagnosis and treatment of benign duodenal tumor].
  • OBJECTIVE: To investigate the diagnosis and treatment of benign duodenal tumor.
  • METHODS: Clinical data of 14 patients with benign duodenal tumor confirmed pathologically or by operation from Oct.1988 to Oct.2001 were analyzed retrospectively.
  • Upper abdominal discomfort (64% ), gastrointestinal bleeding(50% ) and abdominal pain(20% ) were common manifestations.
  • Five cases received duodenoscope and the diagnosis was confirmed in 4 cases.
  • Computed tomographic scan and B-ultrasound were performed in 2 cases and only one case was diagnosed.
  • Eleven cases (79% ) got definite diagnosis before operation.
  • Tumor resection was performed in all patients.
  • CONCLUSION: Upper abdominal discomfort and gastrointestinal bleeding are common features in patients with benign duodenal tumor.
  • Surgical tumor resection is the first choice of treatment.
  • [MeSH-major] Duodenal Neoplasms / diagnosis. Duodenal Neoplasms / surgery

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  • (PMID = 16148996.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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63. Kitagawa H, Okabayashi T, Nishimori I, Kobayashi M, Sugimoto T, Akimori T, Kohsaki T, Miyaji E, Onishi S, Araki K: Rapid growth of mucinous cystic adenoma of the pancreas following pregnancy. Int J Gastrointest Cancer; 2006;37(1):45-8
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  • At 8 mo postpartum, she became aware of an upper abdominal tumor.
  • The patient underwent tumor resection at 11 mo postpartum.
  • Pathological examination of the tumor revealed mucin-producing columnar epithelial cells lining the cystic wall with ovarian-type stromal tissue and no findings indicative of malignancy, giving a diagnosis of mucinous cystic adenoma of the pancreas.
  • Postpartum rapid growth of a benign mucinous cystic neoplasm might be linked to the production of female sex hormones during lactation.
  • [MeSH-major] Adenoma / pathology. Cystadenocarcinoma, Mucinous / pathology. Pancreatic Neoplasms / pathology. Pregnancy Complications, Neoplastic / pathology

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  • [Cites] Am Surg. 1999 Feb;65(2):105-11 [9926740.001]
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  • (PMID = 17290080.001).
  • [ISSN] 1537-3649
  • [Journal-full-title] International journal of gastrointestinal cancer
  • [ISO-abbreviation] Int J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Brønden LB, Eriksen T, Kristensen AT: Oral malignant melanomas and other head and neck neoplasms in Danish dogs--data from the Danish Veterinary Cancer Registry. Acta Vet Scand; 2009;51:54
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  • [Title] Oral malignant melanomas and other head and neck neoplasms in Danish dogs--data from the Danish Veterinary Cancer Registry.
  • Neoplasms originating in the head and neck region are a heterogeneous group.
  • Also the proportions of benign and malignant neoplasms of different locations in dogs were compared using Fisher's exact test.
  • RESULTS: A total of 1768 cases of neoplasias (679 malignant, 826 benign, 263 unknown) were submitted.
  • Of all neoplasias HNC accounted for 7.2% (n = 128).
  • Of these, 64 (50%) were malignant and 44 (34%) benign.
  • The most common types of malignant neoplasia were SCC (18; 28% of malignant), OMM (13; 20% of malignant), soft tissue sarcoma (11; 17% of malignant) and adenocarcinoma (5; 11% of malignant).
  • The most common types of benign neoplasms were adenoma (7; 16% of benign), polyps (6; 14% of benign) and fibroma (5; 11% of benign).
  • CONCLUSIONS: In the current study, the proportion of neoplasia in the head and neck region in dogs in Denmark was similar to other canine studies and significantly more common than in humans with a large proportion of malignancies.
  • [MeSH-major] Dog Diseases / epidemiology. Head and Neck Neoplasms / veterinary. Melanoma / veterinary. Mouth Neoplasms / veterinary. Registries

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  • (PMID = 20021647.001).
  • [ISSN] 1751-0147
  • [Journal-full-title] Acta veterinaria Scandinavica
  • [ISO-abbreviation] Acta Vet. Scand.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803174
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65. Arai E, Nishida Y, Tsukushi S, Sugiura H, Ishiguro N: Intramuscular granular cell tumor in the lower extremities. Clin Orthop Relat Res; 2010 May;468(5):1384-9
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  • [Title] Intramuscular granular cell tumor in the lower extremities.
  • Granular cell tumors are uncommon but typically histologically benign neoplasms that occasionally behave as malignant tumors.
  • Differentiation of benign granular cell tumors from malignant counterparts with radiographic and/or histologic analysis is crucial for physicians.
  • We retrospectively studied five cases of intramuscular granular cell tumors arising in the lower extremities.
  • All tumors had been histologically diagnosed as benign and were resected with a wide surgical margin.
  • Intramuscular granular cell tumors can be diagnosed based on their characteristic MRI features, such as peripheral high intensity on T2-weighed images, and histologic evaluation.
  • The histologic criteria described by Fanburg-Smith et al. can differentiate malignant granular cell tumors from benign tumors.
  • A wide resection seems suitable for most granular cell tumors in the extremities.
  • [MeSH-major] Granular Cell Tumor / diagnosis. Leg
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Prognosis. Retrospective Studies. Time Factors

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  • (PMID = 19760336.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2853648
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66. Lito P, Pantanowitz L, Marotti J, Aboulafia DM, Campbell V, Bower M, Dezube BJ: Gastroenteropancreatic neuroendocrine tumors in patients with HIV infection: a trans-Atlantic series. Am J Med Sci; 2009 Jan;337(1):1-4
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  • [Title] Gastroenteropancreatic neuroendocrine tumors in patients with HIV infection: a trans-Atlantic series.
  • BACKGROUND: Non-AIDS-defining cancers are an important problem in HIV-infected patients.
  • The occurrence of neuroendocrine (NE) tumors in sites other than the lung and skin has not been well characterized in the setting of concurrent HIV infection.
  • METHODS: HIV-positive patients with biopsy-confirmed NE tumors localized to the gastrointestinal tract were identified based on the personal archives of the authors.
  • RESULTS: We identified 4 adult patients, mean age 42 years (range: 37-47) infected with HIV, who developed NE tumors originating in their gastrointestinal tact.
  • A specialized diagnostic work-up was required, including serum chromogranin and urinary 5-hydroxyindoleacetic acid levels, colonoscopy, radioactive isotope scans, and the demonstration of NE differentiation in procured pathologic material.
  • The spectrum of tumors ranged from benign (typical carcinoid) to highly aggressive neoplasms (NE carcinoma).
  • CONCLUSIONS: These cases serve to broaden the spectrum of neoplasms that may be encountered in the current HIV era, and illustrate the difficulty in establishing the diagnosis of NE tumors in the context of HIV infection.
  • [MeSH-major] Gastrointestinal Neoplasms / etiology. HIV Infections / complications. Neuroendocrine Tumors / etiology. Pancreatic Neoplasms / etiology

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  • (PMID = 19155751.001).
  • [ISSN] 0002-9629
  • [Journal-full-title] The American journal of the medical sciences
  • [ISO-abbreviation] Am. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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67. Russo A, Zaottini A: [Diagnosis of synovial sarcoma of the knee accidentally revealed by trauma. Role of ultrasound. Differential diagnosis by scar-hematoma]. Ann Ital Chir; 2009 Mar-Apr;80(2):151-7
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  • [Title] [Diagnosis of synovial sarcoma of the knee accidentally revealed by trauma. Role of ultrasound. Differential diagnosis by scar-hematoma].
  • [Transliterated title] Diagnosi di sarcoma sinoviale del ginocchio fortuitamente favorita da evento traumatico. Il contributo dell'ecografia in urgenza al sospetto clinico e la diagnosi differenziale con l'ematoma in fase di cicatrizzazione.
  • Generally arising in the contest of joint or from immediately surrounding anatomical sites, first of all affecting inferior limbs (2/3), a sarcoma of the knee, elective anatomical site, is described, accidentally diagnosed after traumatic event.
  • Exhibiting a very poor 5 year survey, (55%), related to dimension, distal or proximal arising, necrosis rate and grading, it's the most fequently soft tissue malignancy misdiagnosed with benign neoplasms, such as Baker cyst or villonodular pigmented synovitis, considering its deceiving macroscopic and chronological features; the differential diagnosis seems to be very hard, relying on histhological biopsy.
  • [MeSH-major] Cicatrix, Hypertrophic / ultrasonography. Hematoma / ultrasonography. Knee Injuries / ultrasonography. Knee Joint / ultrasonography. Sarcoma, Synovial / ultrasonography. Soft Tissue Neoplasms / ultrasonography
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Incidental Findings. Male. Middle Aged. Prognosis. Treatment Outcome

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  • (PMID = 19681299.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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68. Naama O, Gazzaz M, Akhaddar A, Belhachmi A, Asri A, Elmostarchid B, Elbouzidi A, Kadiri B, Boucetta M: Cavernous hemangioma of the skull: 3 case reports. Surg Neurol; 2008 Dec;70(6):654-9
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  • BACKGROUND: Intraosseous cavernous hemangiomas of the bone are uncommon tumors, accounting for 0.7% to 1% of all bone neoplasms.
  • Calvarial cavernous hemangioma is rare, comprising about 0.2% of all benign neoplasms of the skull.
  • CONCLUSION: Skull cavernous hemangiomas are rare benign tumors.
  • The preferred treatment is complete tumor removal with normal bony margins.
  • Consequently, the diagnosis is most often made during surgical resection.
  • [MeSH-major] Hemangioma, Cavernous / pathology. Skull Neoplasms / pathology

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  • (PMID = 18207223.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Spinelli P, Calarco G, Mancini A, Ni XG: Operative colonoscopy in cancer patients. Minim Invasive Ther Allied Technol; 2006;15(6):339-47
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  • Gastrointestinal endoscopy has experienced tremendous developments in technology and equipment over the past decades.
  • It is not only a diagnostic tool, but it also allows some interventional treatments in benign and malignant digestive diseases.
  • [MeSH-major] Colonoscopy / methods. Colorectal Neoplasms / therapy

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  • (PMID = 17190658.001).
  • [ISSN] 1364-5706
  • [Journal-full-title] Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy
  • [ISO-abbreviation] Minim Invasive Ther Allied Technol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 44
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70. Santos RR, Damasceno RW, de Pontes FS, Cursino SR, Nishiwaki-Dantas MC, Vital Filho J, Dantas PE: Ten-year follow-up of a case series of primary epithelial neoplasms of the lacrimal gland: clinical features, surgical treatment and histopathological findings. Arq Bras Oftalmol; 2010 Jan-Feb;73(1):33-9
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  • [Title] Ten-year follow-up of a case series of primary epithelial neoplasms of the lacrimal gland: clinical features, surgical treatment and histopathological findings.
  • PURPOSE: To describe and analyze the features of a cases series of patients with primary epithelial neoplasms of the lacrimal gland, its surgical treatment, and histopathological findings.
  • METHODS: Retrospective evaluation of files from patients with primary epithelial neoplasms of the lacrimal gland in the period from 1997 to 2007.
  • All patients with primary epithelial tumors of the lacrimal gland were included in this study.
  • The slides with histological sections of the tumors were reviewed by the same pathologist.
  • RESULTS: During the study period, there were 12 patients, 5 (41.7%) with benign tumors, all pleomorphic adenomas (benign mixed tumor) and 7 (58.3%) with malignant neoplasms, thus distributed: four cases of adenoid cystic carcinoma, two of mucoepidermoid carcinoma and one carcinoma expleomorphic adenoma.
  • Globally, patients mean age was 54.1 years-old (ranging from 14 to 70 years-old), with mean age of 52.4 years-old (ranging from 14 to 65 years-old) for benign neoplasms, and 55.3 years-old for malignant neoplasms (ranging from 26 to 70 years-old).
  • CONCLUSIONS: The most frequent primary epithelial neoplasms of the lacrimal gland were pleomorphic adenoma and adenoid cystic carcinoma during the study period.
  • Malignant tumors were more frequent than benign tumors.
  • The histopathological diagnosis and the disease initial stage can play a significant role in patient's survival.
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Young Adult

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  • (PMID = 20464111.001).
  • [ISSN] 1678-2925
  • [Journal-full-title] Arquivos brasileiros de oftalmologia
  • [ISO-abbreviation] Arq Bras Oftalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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71. Tian W, Li X, Li D, Liu X, Lin S, Liang Y: [Imageology features and transoral approach of benign parapharyngeal space tumors]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2010 Nov;24(21):983-6
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  • [Title] [Imageology features and transoral approach of benign parapharyngeal space tumors].
  • OBJECTIVE: To analyze the imageology features of benign parapharyngeal space (PPS) tumors, and also to summarize our experience in removing PPS benign tumors through transoral approach.
  • METHOD: A retrospective review was conducted to 48 patients with benign tumors in PPS during a 10-year period.
  • RESULT: CT scan and MRI often provided complementary information to help the surgeons delineate the size, precise location and likely cause of these tumors.
  • The transoral approach described herein safely allowed for en bloc resection of most benign neoplasms.
  • CONCLUSION: CT or MRI scan can distinguish prestyloid from poststyloid lesions, and to assess the extension of the tumor as well as its relationship with adjacent structures.
  • The transoral approach safely provides access to some benign PPS tumors with a low rate of complications and recurrence as well as traditional transcervical approaches.
  • [MeSH-major] Neoplasms / diagnosis. Neoplasms / surgery. Pharyngeal Neoplasms / diagnosis. Pharyngeal Neoplasms / surgery

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  • (PMID = 21261019.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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72. Kimchi NA, Eliakim R, Suissa A, Scapa E: [The contribution of capsule endoscopy to the diagnosis of small-bowel tumors in cases of obscure overt gastrointestinal bleeding]. Harefuah; 2006 Nov;145(11):811-4, 862, 861
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  • [Title] [The contribution of capsule endoscopy to the diagnosis of small-bowel tumors in cases of obscure overt gastrointestinal bleeding].
  • GOALS: To review our experience with the diagnosis of small bowel tumors by CE in patients with obscure overt gastrointestinal bleeding.
  • RESULTS: Among 156 patients who underwent CE examination (including 58 patients with obscure overt bleeding), five patients, all of whom presented with melena, were diagnosed as having a small bowel tumor.
  • Three tumors were found in one patient (two ileal carcinoids and one ileal benign stromal tumor).
  • A jejunal benign stromal tumor was diagnosed in two other patients by push enteroscopy.
  • One of these was missed by a subsequent capsule endoscopy examination, and in the other, only active bleeding was detected by prior capsule endoscopy.
  • In two patients, three small tumors were detected, beyond the reach of push enteroscopy, but surgical confirmation was not available.
  • No tumors were found among patients in whom the indication for CE examination was not obscure overt bleeding.
  • CONCLUSIONS: The possibility of finding a small bowel tumor emphasizes the role of capsule endoscopy in patients with obscure overt gastrointestinal bleeding.
  • [MeSH-major] Capsule Endoscopy / methods. Gastrointestinal Hemorrhage / etiology. Intestinal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Female. Humans. Jejunal Neoplasms / diagnosis. Male. Middle Aged. Retrospective Studies

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  • (PMID = 17183952.001).
  • [ISSN] 0017-7768
  • [Journal-full-title] Harefuah
  • [ISO-abbreviation] Harefuah
  • [Language] heb
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Israel
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73. Seo YS, Park JJ, Kim BG, Kim JH, Kim JH, Kim CH, Kim JY, Byun KS, Bak YT: Segmental amputation of esophagus with bronchial-wall rupture during removal of a stent for benign esophageal stricture. Gastrointest Endosc; 2006 Jul;64(1):141-3
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  • [Title] Segmental amputation of esophagus with bronchial-wall rupture during removal of a stent for benign esophageal stricture.
  • [MeSH-minor] Aged. Bronchi / injuries. Carcinoma, Squamous Cell / radiotherapy. Esophageal Neoplasms / radiotherapy. Esophagitis / etiology. Fatal Outcome. Female. Humans. Intraoperative Complications. Prosthesis Design. Radiation Injuries / complications. Respiratory Insufficiency / etiology. Rupture

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  • (PMID = 16813827.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Khalid U, McGough C, Hackett C, Blake P, Harrington KJ, Khoo VS, Tait D, Norman AR, Andreyev HJ: A modified inflammatory bowel disease questionnaire and the Vaizey Incontinence questionnaire are more sensitive measures of acute gastrointestinal toxicity during pelvic radiotherapy than RTOG grading. Int J Radiat Oncol Biol Phys; 2006 Apr 1;64(5):1432-41
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  • [Title] A modified inflammatory bowel disease questionnaire and the Vaizey Incontinence questionnaire are more sensitive measures of acute gastrointestinal toxicity during pelvic radiotherapy than RTOG grading.
  • PURPOSE: Simple scales with greater sensitivity than Radiation Therapy Oncology Group (RTOG) grading to detect acute gastrointestinal toxicity during pelvic radiotherapy, could be clinically useful.
  • METHODS AND MATERIALS: Do questionnaires used in benign gastrointestinal diseases detect toxicity in patients undergoing radiotherapy?
  • After 5 weeks of treatment, patients with gynecologic and gastrointestinal cancer were more symptomatic than urologic patients (p = 0.012; p = 0.014).
  • [MeSH-major] Gastrointestinal Neoplasms / radiotherapy. Gastrointestinal Tract / radiation effects. Genital Neoplasms, Female / radiotherapy. Surveys and Questionnaires / standards. Urologic Neoplasms / radiotherapy

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  • (PMID = 16580497.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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75. Inoue H, Sasajima K, Kaga M, Sugaya S, Sato Y, Wada Y, Inui M, Satodate H, Kudo SE, Kimura S, Hamatani S, Shiokawa A: Endoscopic in vivo evaluation of tissue atypia in the esophagus using a newly designed integrated endocytoscope: a pilot trial. Endoscopy; 2006 Sep;38(9):891-5
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  • BACKGROUND AND STUDY AIMS: A newly designed magnifying endoscope featuring an endocytoscopy function provided by ultrahigh magnification was evaluated in a pilot study in patients with various types of benign and malignant pathology in the esophagus.
  • CONCLUSIONS: These preliminary results suggest that incorporating endocytoscopy facilities into a standard endoscope may be helpful in characterizing tissue in a variety of esophageal lesions.
  • The potential clinical impact of this method in relation to other gastrointestinal organs requires further study.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Endoscopes, Gastrointestinal. Esophageal Neoplasms / pathology. Esophagus / pathology

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  • (PMID = 16981105.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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76. Kan H, Suzuki H, Shinji S, Naito Z, Furukawa K, Tajiri T: Case of an inflammatory fibroid polyp of the cecum. J Nippon Med Sch; 2008 Jun;75(3):181-6
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  • An inflammatory fibroid polyp (IFP) is a rare benign lesion, originating in the submucosa of the gastrointestinal tract.
  • The lesion was diagnosed to be a submucosal tumor.
  • Immunohistochemical staining of the spindle-shaped cells, which were present around the small vessels in the stroma of the tumor, showed that the tissue expressed vimentin but not alpha-smooth muscle actin, desmin, S-100, c-kit or CD 34.
  • [MeSH-major] Cecal Neoplasms / surgery. Intestinal Polyps / surgery
  • [MeSH-minor] Cecum / pathology. Cecum / surgery. Colonoscopy. Digestive System Surgical Procedures / methods. Female. Humans. Ileum / surgery. Laparoscopy. Lymph Node Excision. Middle Aged. Treatment Outcome

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  • (PMID = 18648178.001).
  • [ISSN] 1345-4676
  • [Journal-full-title] Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
  • [ISO-abbreviation] J Nippon Med Sch
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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77. Zissis D, Zizi-Serbetzoglou A, Glava C, Grammatoglou X, Katsamagkou E, Nikolaidou ME, Vasilakaki T: Glomus tumor of the stomach: a case report. J BUON; 2008 Oct-Dec;13(4):581-4
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  • [Title] Glomus tumor of the stomach: a case report.
  • Glomus tumors are relatively uncommon benign neoplasms, most common in the skin and subcutaneous tissue, but can also occur in the viscera, most often in the stomach.
  • Preoperative diagnosis, when the tumor occurs in the stomach, seems difficult but is important, since glomus tumors of the stomach are essentially benign and amenable to conservative excision, contrary to aggressive gastric neoplasms.
  • We describe the case of a 75-year-old man presented to the emergency department with gastrointestinal bleeding and epigastric pain.
  • Biopsies taken from the lesion showed morphological and immunohistochemical [positivity for alphasmooth muscle actin (alpha-SMA) and vimentin, negativity for CD34, CD117, chromogranin, synaptophysin, desmin and S-100 protein] characteristics attributable to glomus tumor.
  • Histological examination of the tumor confirmed the diagnosis of gastric glomus tumor.
  • [MeSH-major] Glomus Tumor / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Immunohistochemistry. Male

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  • (PMID = 19145686.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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78. Carlsten JR, Lewis MD, Saddler K, Reilly P, Pan T, Gnepp DR, Robinson-Bostom L: Spiradenocylindrocarcinoma: a malignant hybrid tumor. J Cutan Pathol; 2005 Feb;32(2):166-71
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  • [Title] Spiradenocylindrocarcinoma: a malignant hybrid tumor.
  • BACKGROUND: Eccrine spiradenomas and cylindromas are benign, slowly growing, cutaneous adnexal neoplasms, recently hypothesized to arise from a common pluripotential cell; malignant variants are rare.
  • Benign tumors demonstrating both spiradenomatous and cylindromatous features have been infrequently reported.
  • Recent immunohistochemical studies of these two tumors have provided compelling evidence that these two tumors may merely represent a single tumor type with a spectrum of histological features.
  • CASE REPORT: We describe two cases of a malignant variant of this rare hybrid tumor occurring in a 62-year-old male and a 72-year-old female.
  • CONCLUSION: We propose the term 'spiradenocylindrocarcinoma' to describe malignant tumors with features of both a spiradenoma and a cylindroma.
  • In conjunction with histological features of malignancy, p53 and Ki-67 immunohistochemical staining may provide helpful clues in determining the malignant potential of this tumor.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Female. Gastrointestinal Neoplasms / secondary. Humans. Immunohistochemistry. Male. Middle Aged

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  • [ErratumIn] J Cutan Pathol. 2005 Jul;32(6):453
  • (PMID = 15606677.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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79. Zang L, Hu WG, Yan XW, Zhang T, Ma JJ, Ye Q, Feng B, Wang ML, Lu AG, Li JW, Zhong J, Zheng MH: Laparoscopic treatment for small intestinal bleeding: a report of 77 cases. J Laparoendosc Adv Surg Tech A; 2010 Jul-Aug;20(6):521-5
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  • Hence, small intestinal disease is an important differential diagnosis when hematochezia or melena occurs, especially when gastric and colonic diseases are excluded.
  • With the development of laparoscopic technique, laparoscopic operations are more frequently applied to surgical disease, despite their benign or malignant nature.
  • There was 1 case of gastrointestinal stromal tumor with local recurrence and hepatic metastasis.
  • Four patients died from metastasis of malignant tumors during the follow-up from 2 to 70 months after operations.
  • No trocar site or wound recurrences were noted.
  • [MeSH-major] Gastrointestinal Hemorrhage / surgery. Intestine, Small. Laparoscopy
  • [MeSH-minor] Adolescent. Adult. Aged. Blood Loss, Surgical. Female. Humans. Intestinal Neoplasms / diagnosis. Length of Stay. Male. Melena / diagnosis. Middle Aged. Postoperative Complications. Retrospective Studies. Treatment Outcome

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  • [CommentIn] J Laparoendosc Adv Surg Tech A. 2010 Nov;20(9):771 [20874417.001]
  • (PMID = 20687815.001).
  • [ISSN] 1557-9034
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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80. Sperti C, Pasquali C, Fiore V, Bissoli S, Chierichetti F, Liessi G, Pedrazzoli S: Clinical usefulness of 18-fluorodeoxyglucose positron emission tomography in the management of patients with nonpancreatic periampullary neoplasms. Am J Surg; 2006 Jun;191(6):743-8
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  • [Title] Clinical usefulness of 18-fluorodeoxyglucose positron emission tomography in the management of patients with nonpancreatic periampullary neoplasms.
  • BACKGROUND: 18-Fluorodeoxyglucose positron emission tomography (18-FDG PET) has been investigated for the diagnosis and staging of gastrointestinal malignancies including pancreatic adenocarcinoma.
  • The aim of this study was to examine the clinical usefulness of 18-FDG PET in the diagnosis and follow-up evaluation of patients with periampullary neoplasms.
  • RESULTS: Between January 1998 and December 2003, 14 ampullary, 7 bile duct, and 4 duodenal tumors were included in the study.
  • PET showed increased focal uptake in 22 patients (88%): 11 of 14 (79%) ampullary tumors, and 100% of bile duct and duodenal tumors.
  • CONCLUSIONS: 18-FDG PET is very sensitive for detecting periampullary neoplasms.
  • It may be useful to differentiate benign or borderline lesions from invasive tumors when no mass has been identified by traditional imaging.
  • Finally, it is very useful in the follow-up evaluation of resected patients to identify recurrent disease or other malignancies.
  • [MeSH-major] Ampulla of Vater / radionuclide imaging. Bile Duct Neoplasms / radionuclide imaging. Duodenal Neoplasms / radionuclide imaging. Pancreatic Neoplasms / radionuclide imaging. Positron-Emission Tomography
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Fluorodeoxyglucose F18. Humans. Laparotomy / methods. Male. Middle Aged. Neoplasm Staging. Risk Assessment. Sensitivity and Specificity

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  • (PMID = 16720142.001).
  • [ISSN] 0002-9610
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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81. Takeyama H, Funahashi H, Sawai H, Takahashi H, Yamamotorm M, Akamo Y, Manabe T: Expression of alpha6 integrin subunit is associated with malignancy in gastric gastrointestinal stromal tumors. Med Sci Monit; 2007 Feb;13(2):CR51-6
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  • [Title] Expression of alpha6 integrin subunit is associated with malignancy in gastric gastrointestinal stromal tumors.
  • BACKGROUND: Gastrointestinal stromal tumors (GISTs) are the most common non-epithelial neoplasms of the gastrointestinal tract.
  • The c-kit negative examples among the original 48 patients with gastric submucosal and muscle layer tumors were excluded from the study.
  • RESULTS: There was a significant correlation between p53 protein expression and tumor malignancy.
  • The positive staining for proliferating cell nuclear antigen was observed in all patients, and the mean tumor proliferation index for benign and malignant groups were 3.0% and 16.3%, respectively. alpha5beta1 integrin and alpha6 integrin subunit were expressed from moderately to strongly in tumor cells, and alpha 6 integrin subunit expression correlated significantly with whether tumors were classified as benign or malignant.
  • However, there were no significant differences between the survival of GIST patients and integrin expression, mitotic rate, tumor size, or tumor malignancy.
  • It may be useful in supporting other parameters, such as p53, MI, and tumor size.
  • [MeSH-major] Gastrointestinal Stromal Tumors / metabolism. Integrin alpha6 / metabolism. Stomach Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 17261983.001).
  • [ISSN] 1234-1010
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Integrin alpha6; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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82. Chon SH, Lee CB, Shinn SH, Heo JN, Paik SS: Rib xanthoma resected by video-assisted thoracoscopic surgery using a bone punch. Surg Laparosc Endosc Percutan Tech; 2009 Feb;19(1):e15-6
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  • Xanthomas of the rib are extremely rare benign neoplasms, most commonly reported in soft tissue, but rarely in bone.
  • We report a case of a 4-cm xanthoma of the rib resected by video-assisted thoracoscopic surgery and pulled through a 2-cm port incision around the patient's areola.
  • To the best of our knowledge, there are only 8 other such cases, and none of which were removed by thoracoscopic surgery.
  • [MeSH-major] Bone Neoplasms / surgery. Ribs / surgery. Thoracic Surgery, Video-Assisted. Xanthomatosis / surgery

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  • (PMID = 19238049.001).
  • [ISSN] 1534-4908
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Kamimura H, Mochiki E, Kamiyama Y, Aihara R, Kimura H, Kuwano H: Gastrointestinal stromal tumor of the stomach: report of a case. Hepatogastroenterology; 2005 Jul-Aug;52(64):1297-300
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  • [Title] Gastrointestinal stromal tumor of the stomach: report of a case.
  • We report herein a case of a 65-year-old woman who had a gastrointestinal stromal tumor (GIST) of the stomach.
  • Preoperative endoscopic and X-ray examinations showed a spherical submucosal tumor in the gastric fornix.
  • We resected the tumor by laparoscopic surgery, because it was detected by computed tomography (CT) and positron emission tomography (PET), and they did not detect distant metastasis.
  • Postoperative histologic examination revealed that the tumor was composed of spindle-shaped cells with elongated nuclei and showed little mitosis.
  • The tumor did not show differentiation toward smooth muscle or neural cells.
  • Pathological findings showed this tumor was probably benign.
  • [MeSH-major] Gastrointestinal Stromal Tumors / diagnosis. Gastrointestinal Stromal Tumors / surgery. Stomach Neoplasms / diagnosis. Stomach Neoplasms / surgery

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  • (PMID = 16001681.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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84. Ginès A, Wiersema MJ, Clain JE, Pochron NL, Rajan E, Levy MJ: Prospective study of a Trucut needle for performing EUS-guided biopsy with EUS-guided FNA rescue. Gastrointest Endosc; 2005 Oct;62(4):597-601
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  • [Title] Prospective study of a Trucut needle for performing EUS-guided biopsy with EUS-guided FNA rescue.
  • The use of a Trucut needle to perform EUS-guided biopsy (EUS-TCB) may improve the results or simplify the procedure.
  • METHODS: Patients with a known or a suspected malignancy referred for a diagnostic and/or staging EUS examination were enrolled in a prospective study.
  • If the Trucut failed to obtain an adequate sample or when the "in room" touch preparation was benign, EUS-FNA was performed with a standard 22-gauge FNA needle.
  • By using EUS-TCB, we were able to obtain a sample for diagnosis in all but 3 patients (one pancreatic mass and two lymph nodes) in which technical problems arose.
  • In these patients, the diagnosis was obtained in two cases by EUS-FNA and in the other one by EUS-TCB from the primary pancreatic tumor.
  • CONCLUSIONS: EUS-TCB is a safe and an accurate procedure to obtain a histologic diagnosis in patients with known or suspected malignancies.
  • [MeSH-major] Endosonography. Gastrointestinal Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle / instrumentation. Diagnosis, Differential. Equipment Design. Equipment Safety. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prospective Studies. Reproducibility of Results

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  • [CommentIn] Gastrointest Endosc. 2005 Oct;62(4):602-4 [16185977.001]
  • (PMID = 16185976.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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85. Min YW, Kim YH, Yun HS, Kil JS, Kim YC, Yun SH, Kim KM, Kim JJ: [A case of benign schwannoma in the ascending colon]. Korean J Gastroenterol; 2007 Dec;50(6):398-401
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  • [Title] [A case of benign schwannoma in the ascending colon].
  • Schwannomas are rare tumors derived from the cells of Schwann which form the neural sheath.
  • Some patients with gastrointestinal schwannoma have been previously reported in the literature.
  • A 49-year-old woman was admitted with complaint of abdominal pain and investigations revealed the presence of a 4 cm sized mass in the ascending colon.
  • Following right hemicolectomy, histopathology and immunohistochemistry confirmed the colonic lesion to be a benign schwannoma.
  • [MeSH-major] Colon, Ascending / pathology. Colonic Neoplasms / diagnosis. Neurilemmoma / diagnosis

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  • (PMID = 18159179.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / S100 Proteins
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86. Amaro C, Freitas I, Lamarão P, Afonso A, Skrzypczak M, Heinritz W: Multiple trichoepitheliomas--a novel mutation in the CYLD gene. J Eur Acad Dermatol Venereol; 2010 Jul;24(7):844-6
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  • BACKGROUND: Trichoepitheliomas are benign neoplasms with follicular differentiation.
  • OBJECTIVE: The authors report the case of a 9-year-old African girl with multiple facial trichoepitheliomas in whom a mutation in the CYLD gene was hypothesised.
  • RESULTS: A novel heterozygous mutation in exon 18 of the CYLD gene (c.2449delT) was identified, with a deletion of one nucleotide resulting in a premature translational termination codon at amino acid position 831 on the affected allele (p.Cys817Valfs X15).
  • [MeSH-major] Mutation. Skin Neoplasms / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 19929939.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins; 9007-49-2 / DNA
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87. Lee DH, Lee SH, Sung JK: Inflammatory myofibroblastic tumor on intercostal nerve presenting as paraneoplastic pemphigus with fatal pulmonary involvement. J Korean Med Sci; 2007 Aug;22(4):735-9
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  • [Title] Inflammatory myofibroblastic tumor on intercostal nerve presenting as paraneoplastic pemphigus with fatal pulmonary involvement.
  • Inflammatory myofibroblastic tumors (IMTs) are benign neoplasms that can occur at different anatomic sites with nonspecific clinical symptoms.
  • A 48-yr-old woman presented with a 2-month history of a relapsed oral ulcer, progressive dyspnea, and a thoracic pain induced by breathing.
  • A tumorous mass was noticed in the right costodiaphragmatic recess on chest computed tomography and magnetic resonance imaging, and the patient underwent a right costotransversectomy with excision of the tumor, which originated from the 12th intercostal nerve.
  • Histology and immunohistochemistry showed that the tumor was an IMT of the intercostal nerve.
  • The patient's postoperative course was not favorable; dyspnea persisted after surgery, and a progressive pulmonary compromise developed.
  • A brief review of the heterogeneous theories concerning the pathogenesis, clinicopathological features, and differential diagnosis of this disease entity is presented.
  • [MeSH-major] Granuloma, Plasma Cell / pathology. Intercostal Nerves / pathology. Paraneoplastic Syndromes / pathology. Pemphigus / pathology. Peripheral Nervous System Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Fatal Outcome. Female. Humans. Lung Diseases / etiology. Lung Diseases / pathology. Middle Aged

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  • (PMID = 17728520.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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88. Van Patten K, Parkash V, Jain D: Cadherin expression in gastrointestinal tract endometriosis: possible role in deep tissue invasion and development of malignancy. Mod Pathol; 2010 Jan;23(1):38-44
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  • [Title] Cadherin expression in gastrointestinal tract endometriosis: possible role in deep tissue invasion and development of malignancy.
  • The mechanism of deep tissue invasion in gastrointestinal endometriosis is unknown and may be related to the altered expression of these cell surface proteins.
  • The goal of this study was to evaluate the expression of N-cadherin, E-cadherin, and beta-catenin in peritoneal endometriotic implants, gastrointestinal endometriosis, and carcinoma arising in gastrointestinal endometriosis.
  • Cases of peritoneal endometriosis, gastrointestinal endometriosis, and carcinoma arising in gastrointestinal endometriosis were identified from our pathology database.
  • A total of 38 cases (peritoneal endometriosis (n=14), gastrointestinal endometriosis (n=21: 11 colon, 8 appendix, 2 small bowel), and 3 cases of endometrioid carcinoma arising in colonic endometriosis (n=3)) were included in the study.
  • Peritoneal and gastrointestinal endometriosis also showed markedly decreased expression of N-cadherin compared with proliferative endometrium.
  • All three cases of carcinoma arising in colonic endometriosis showed a total loss of N-cadherin in the tumor, but preserved E-cadherin and beta-catenin expression.
  • In these cases, areas of benign endometriotic glands near the tumor showed weak and focal N-cadherin expression that was gradually lost.
  • Moderate-to-strong membranous staining for beta-catenin expression and variable intensity of E-cadherin expression was seen diffusely in normal endometrium and all study cases.
  • These results strongly suggest that alterations of N-cadherin expression in gastrointestinal endometriosis may have an important role in the mechanism that underlies deep tissue invasion, and possibly also in the development of malignancy.
  • [MeSH-major] Cadherins / biosynthesis. Cell Transformation, Neoplastic / metabolism. Endometrial Neoplasms / metabolism. Endometriosis / metabolism. Gastrointestinal Diseases / metabolism


89. Tascilar O, Cakmak GK, Gün BD, Uçan BH, Balbaloglu H, Cesur A, Emre AU, Comert M, Erdem LO, Aydemir S: Clinical evaluation of submucosal colonic lipomas: decision making. World J Gastroenterol; 2006 Aug 21;12(31):5075-7
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  • Even lipomas are the most common mesenchymal benign tumors of the gastrointestinal tract, symptomatic colonic presentation is rare.
  • [MeSH-major] Colonic Neoplasms / diagnosis. Colonic Neoplasms / therapy. Intestinal Mucosa / pathology. Lipoma / diagnosis. Lipoma / therapy
  • [MeSH-minor] Adult. Aged. Colonoscopy. Diagnosis, Differential. Female. Humans. Male. Tomography, X-Ray Computed / methods

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  • (PMID = 16937511.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4087418
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90. Ballarin R, Spaggiari M, Di Benedetto F, Montalti R, Masetti M, De Ruvo N, Romano A, Guerrini GP, De Blasiis MG, Gerunda GE: Do not deny pancreatic resection to elderly patients. J Gastrointest Surg; 2009 Feb;13(2):341-8
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  • INTRODUCTION: Radical resection is the only potential cure for pancreatic malignancies and a useful treatment for other benign diseases, such as pancreatitis.
  • DISCUSSION: In the light of these findings and as reported for other series, old age is probably not directly related with any increase in the rate of postoperative complications, but comorbidities (which are naturally related to the patients' previous life) may have a key role in the postoperative course.
  • [MeSH-major] Pancreatectomy. Pancreatic Neoplasms / surgery. Postoperative Complications

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  • (PMID = 18784970.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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91. Aminian A, Noaparast M, Mirsharifi R, Bodaghabadi M, Mardany O, Ali FA, Karimian F, Toolabi K: Ileal intussusception secondary to both lipoma and angiolipoma: a case report. Cases J; 2009;2:7099
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  • Lipoma and angiolipoma are common benign neoplasms that occur in the subcutaneous tissue and rarely in the gastrointestinal tract.
  • These tumors are usually asymptomatic but may present with abdominal pain, bleeding and obstruction.
  • Histopathological study showed that one was angiolipoma and other lesions were lipoma.
  • We have described some aspects of diagnosis and treatment of this rare cause of intestinal intussusception.

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  • (PMID = 19829910.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2740257
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92. Soumaoro LT, Teramoto K, Kawamura T, Nakamura N, Sanada T, Sugihara K, Arii S: Benign schwannoma of the pancreas. J Gastrointest Surg; 2005 Feb;9(2):288-90
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  • [Title] Benign schwannoma of the pancreas.
  • We herein describe the clinicopathologic findings of a solitary benign schwannoma occurring in the head of the pancreas.
  • Additionally, the differential diagnosis versus other cystic- and solid-appearing pancreatic masses is briefly discussed.
  • [MeSH-major] Neurilemmoma / diagnosis. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Radiography

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  • (PMID = 15694826.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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93. Levy MJ, Wiersema MJ: Pancreatic neoplasms. Gastrointest Endosc Clin N Am; 2005 Jan;15(1):117-42, x
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  • [Title] Pancreatic neoplasms.
  • Patients who present with signs and symptoms suggesting a pancreatic neoplasm typically undergo initial imaging with transabdominal ultrasound or CT.
  • When a pancreatic mass or fullness is identified, it may represent an inflammatory mass, benign process, or malignancy.
  • Endoscopic ultrasound (EUS) is performed commonly to further characterize the lesion, obtain a tissue diagnosis, and for staging.
  • This article reviews the role of EUS for the diagnosis and staging of pancreatic tumors.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Endosonography / methods. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / ultrasonography
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / ultrasonography. Cyst Fluid / cytology. Cystadenocarcinoma, Mucinous / pathology. Cystadenocarcinoma, Mucinous / ultrasonography. Cystadenoma, Mucinous / pathology. Cystadenoma, Mucinous / ultrasonography. Cystadenoma, Serous / pathology. Cystadenoma, Serous / ultrasonography. Cysts / pathology. Cysts / ultrasonography. Humans. Neuroendocrine Tumors / pathology. Neuroendocrine Tumors / ultrasonography. Pancreatic Diseases / pathology. Pancreatic Diseases / ultrasonography

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  • (PMID = 15555956.001).
  • [ISSN] 1052-5157
  • [Journal-full-title] Gastrointestinal endoscopy clinics of North America
  • [ISO-abbreviation] Gastrointest. Endosc. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 145
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94. Sugár I, Forgács B, István G, Bognár G, Sápy Z, Ondrejka P: Gastrointestinal stromal tumors (GIST). Hepatogastroenterology; 2005 Mar-Apr;52(62):409-13
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  • [Title] Gastrointestinal stromal tumors (GIST).
  • BACKGROUND/AIMS: Gastrointestinal stromal tumors (GIST) are the most frequent non-epithelial tumors of the alimentary tract.
  • GIST's occur throughout the gastrointestinal tract but are generally located in the stomach and the intestine.
  • The tumor size, mitotic rate, cellularity and nuclear pleomorphism are the most important parameters characterizing the biological behavior of tumors.
  • The diagnostic procedures are similar to those of other gastrointestinal neoplasms but only a half of the patients will have correct preoperative histological diagnosis.
  • RESULTS: All but one proved to be benign.
  • CONCLUSIONS: GIST is a rare neoplasm of the GI tract.
  • [MeSH-major] Gastrointestinal Stromal Tumors / diagnosis. Gastrointestinal Stromal Tumors / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Incidental Findings. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies

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  • (PMID = 15816446.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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95. Dionigi G, Dionigi R, Bartalena L, Tanda ML, Piantanida E, Castano P, Annoni M, Boni L, Rovera F, Bacuzzi A, Vanoli P, Sessa F: [Current indications for thyroidectomy]. Minerva Chir; 2007 Oct;62(5):359-72
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  • It accounts for the bulk of work even in reference centers that treat rare endocrine tumors (e.g. adrenal and gastrointestinal tract cancer).
  • Surgeons who correctly perform thyroid surgery can achieve excellent outcomes even in other areas of endocrine surgery.
  • So it is surprising that not more is being done to teach the procedure, which has always been considered something of an art, perhaps because surgical treatment of rare endocrine tumors is more stimulating to teach than routine surgical procedures.
  • Numerous studies have reported that the incidence of complications is high and that the rate is growing: 5% involve permanent injury to the recurrent laryngeal nerve after intervention for a benign tumor, despite repeated reports that the incidence could be reduced to near zero or at least to 1%.
  • [MeSH-minor] Algorithms. Ambulatory Surgical Procedures. Goiter, Nodular / surgery. Graves Disease / surgery. Humans. Minimally Invasive Surgical Procedures. Thyroid Neoplasms / surgery. Thyroid Nodule / surgery. Thyrotoxicosis / surgery. Treatment Outcome. Video-Assisted Surgery

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  • (PMID = 17947947.001).
  • [ISSN] 0026-4733
  • [Journal-full-title] Minerva chirurgica
  • [ISO-abbreviation] Minerva Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 105
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96. Hou YY, Tan YS, Xu JF, Wang XN, Lu SH, Ji Y, Wang J, Zhu XZ: Schwannoma of the gastrointestinal tract: a clinicopathological, immunohistochemical and ultrastructural study of 33 cases. Histopathology; 2006 Apr;48(5):536-45
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  • [Title] Schwannoma of the gastrointestinal tract: a clinicopathological, immunohistochemical and ultrastructural study of 33 cases.
  • AIMS: Thirty-three cases of gastrointestinal schwannomas were analysed to elucidate their peculiar clinicopathological, immunohistochemical and ultrastructural features.
  • Tumour size ranged from 10 to 120 mm in diameter.
  • CONCLUSIONS: Gastrointestinal schwannomas have characteristic histological features, especially the presence of a lymphoid cuff, that are different from their soft tissue and central nervous system counterparts.
  • Gastrointestinal tract schwannomas behave in a benign fashion.
  • [MeSH-major] Gastrointestinal Neoplasms / pathology. Neurilemmoma / pathology

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  • (PMID = 16623779.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Glial Fibrillary Acidic Protein; 0 / S100 Proteins; 0 / Vimentin; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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97. Ponsaing LG, Hansen MB: Therapeutic procedures for submucosal tumors in the gastrointestinal tract. World J Gastroenterol; 2007 Jun 28;13(24):3316-22
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  • [Title] Therapeutic procedures for submucosal tumors in the gastrointestinal tract.
  • This review is part three of three and will present an update on the therapeutic options and procedures concerning gastrointestinal (GI) submucosal tumors (SMTs).
  • The aim of this paper is to investigate the treatments of GI SMTs and to present a case of a gastrointestinal stromal tumor (GIST).
  • Literature searches were performed to find information on therapy for GI SMTs.
  • The choice of treatment of localized tumors is endoscopic resection if possible or, alternatively, laparoscopic resection or surgical resection by an open procedure.
  • However, benign SMTs should only be excised if symptoms are present, and GISTs should be treated with particular precautions.
  • [MeSH-major] Gastrointestinal Neoplasms / therapy
  • [MeSH-minor] Benzamides. Endoscopy, Gastrointestinal. Female. Gastric Mucosa / pathology. Gastrointestinal Stromal Tumors / therapy. Humans. Imatinib Mesylate. Intestinal Mucosa / pathology. Middle Aged. Piperazines / therapeutic use. Pyrimidines / therapeutic use

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  • (PMID = 17659670.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
  • [Number-of-references] 58
  • [Other-IDs] NLM/ PMC4172711
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98. Sailer J, Zacherl J, Schima W: MDCT of small bowel tumours. Cancer Imaging; 2007;7:224-33
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  • Primary benign and malignant neoplasm of the small bowel are rare.
  • Malignant tumours often present late symptoms resulting in a poor prognosis.
  • Early detection of small bowel neoplasms is desirable but challenging for both clinicians and radiologists.
  • The best visualisation of small bowel neoplasms is achieved with CT enteroclysis or enterography and this review discusses these techniques and MDCT characteristics of small bowel tumours.
  • [MeSH-major] Gastrointestinal Neoplasms / radiography. Intestine, Small. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Contrast Media. Diagnosis, Differential. Humans

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  • (PMID = 18083648.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 30
  • [Other-IDs] NLM/ PMC2151330
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99. Mosnier JF, Kandel C, Cazals-Hatem D, Bou-Hanna C, Gournay J, Jarry A, Laboisse CL: N-cadherin serves as diagnostic biomarker in intrahepatic and perihilar cholangiocarcinomas. Mod Pathol; 2009 Feb;22(2):182-90
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  • As a definite immunoprofile of this tumor is missing, the histopathologic diagnosis of intrahepatic cholangiocarcinoma is difficult.
  • The aim of this study was to explore E- and N-cadherin expressions in intrahepatic bile duct tumors, and to determine their potential interest in differential diagnosis.
  • Tissue-microarrays including 20 esophageal, 86 gastric, 8 small bowel, 64 colonic, 18 pancreatic, 6 gallbladder, and 7 extrahepatic biliary tract adenocarcinomas, 22 hepatocellular carcinomas, and normal tissues were constructed.
  • Immunoblot analysis of frozen liver tissues was performed to control the specificity of E- and N-cadherin antibodies used.
  • In normal liver, epithelial cells of intrahepatic bile ducts, whatever their caliber, as well as hepatocytes, coexpressed E- and N-cadherins at their plasma membranes.
  • In cirrhosis, ductular reactions completely expressed E- and N-cadherins.
  • All the benign lesions and 30 of the 45 intrahepatic cholangiocarcinomas (23/29 peripheral and 7/16 hilar) also expressed N-cadherin.
  • The expression of N-cadherin at the plasma membrane of tumor cells was significantly more frequent in peripheral than in hilar intrahepatic cholangiocarcinomas (P=0.003).
  • Among noncholangiocarcinomas, only 1% gastric and 66% gallbladder adenocarcinomas and all the hepatocellular carcinomas expressed N-cadherin at the membrane of tumor cells.
  • Finally, for the diagnosis of intrahepatic cholangiocarcinomas, the specificity value of membranous expression of N-cadherin was 88%, whereas that of the combination cytokeratin 7/membranous N-cadherin was 98%.
  • In the gastrointestinal and liver tract, membranous N-cadherin is restricted to the hepatocytes and intrahepatic biliary cells.
  • In combination with cytokeratin 7 and Hep Par1, N-cadherin is a reliable tool for the histopathological diagnosis of primary hepatic tumors.
  • [MeSH-major] Antigens, CD / analysis. Bile Duct Neoplasms / immunology. Bile Ducts, Intrahepatic / immunology. Biomarkers, Tumor / analysis. Cadherins / analysis. Cholangiocarcinoma / immunology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. France. Humans. Immunoblotting. Immunohistochemistry. Keratin-7 / analysis. Male. Middle Aged. Predictive Value of Tests. Reproducibility of Results. Tissue Array Analysis

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  • (PMID = 18622386.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / CDH1 protein, human; 0 / CDH2 protein, human; 0 / Cadherins; 0 / KRT7 protein, human; 0 / Keratin-7
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100. Ho CH, Chau WK, Hsu HC, Gau JP, You JY, Chen CC: Predictive risk factors and prevalence of malignancy in patients with iron deficiency anemia in Taiwan. Am J Hematol; 2005 Feb;78(2):108-12
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  • Gastrointestinal (GI) tract malignancy is one of the important causes of chronic iron deficiency anemia (IDA).
  • A series of examinations to explore the GI tract were performed either by radiology and/or endoscopy.
  • A Tc-RBC GI bleeding study was also performed, and prevalence and risk factors of malignancy were calculated.
  • Eighteen patients (12.2%) were found to have malignant tumors.
  • Ten (6.8%) had benign tumors, and 96 (64.9%) had other benign conditions.
  • Clinical symptoms and presence of fecal occult blood could not predict malignancy or any GI lesions.
  • [MeSH-major] Anemia, Iron-Deficiency / epidemiology. Gastrointestinal Neoplasms / diagnosis. Gastrointestinal Neoplasms / epidemiology

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15682422.001).
  • [ISSN] 0361-8609
  • [Journal-full-title] American journal of hematology
  • [ISO-abbreviation] Am. J. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-73-2 / Ferritins; EC 1.1.1.27 / L-Lactate Dehydrogenase
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