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1. Mai KT, Elmontaser G, Perkins DG, Thomas J, Stinson WA: Benign Hürthle cell adenoma with papillary architecture: a benign lesion mimicking oncocytic papillary carcinoma. Int J Surg Pathol; 2005 Jan;13(1):37-41
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  • [Title] Benign Hürthle cell adenoma with papillary architecture: a benign lesion mimicking oncocytic papillary carcinoma.
  • We studied the significance of encapsulated Hürthle cell thyroid nodules with papillary structures lacking the nuclear features of papillary thyroid carcinoma (PTC); 19 cases fulfilling these criteria were encountered The patients' ages ranged from 22 to 40 years (32+/-6), and the F:M ratio was 3:1 The tumors measured from 0.5-5 cm (2+/-1.1).
  • The diameter of the tumor cell nuclei ranged from 5.6 to 7.2 microns.
  • Many nodules had nuclei displaying a fine chromatin pattern somewhat resembling those of PTC, but these were present in <20% of the tumor cells.
  • In view of (1) the encapsulation and the uniformity of the constituent cells, (2) the negative or weak immunoreactivity for galectin-3 and HBME and negative to moderate immunoreactivity for CK19, and (3) the absence or paucity of nuclear criteria for the diagnosis of PTC and the absence of lymph node metastasis in all study cases, we believe that these lesions represent the papillary variant of oncocytic follicular adenoma (Hürthle cell adenoma).
  • [MeSH-major] Adenoma / pathology. Adenoma, Oxyphilic / pathology. Carcinoma, Papillary, Follicular / diagnosis. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Chromatin / pathology. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 15735853.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromatin
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2. Rowe EW, Laniado ME, Walker MM, Anup P: Incidental acute prostatic inflammation is associated with a lower percentage of free prostate-specific antigen than other benign conditions of the prostate: a prospective screening study. BJU Int; 2006 May;97(5):1039-42
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  • [Title] Incidental acute prostatic inflammation is associated with a lower percentage of free prostate-specific antigen than other benign conditions of the prostate: a prospective screening study.
  • Biopsies were taken from men with a tPSA of > or = 4 ng/mL, together with those with a tPSA of 1.1-3.99 ng/mL and a f/tPSA of < or = 20%.
  • Histological evidence of prostate cancer, acute inflammation, chronic inflammation, and benign prostatic tissue were noted in biopsy cores, together with the associated f/tPSA values.
  • Men with acute inflammation (27/175, 15%) had significantly lower serum f/tPSA values (mean 13.4%) than those with chronic inflammation (mean 16.6%, P = 0.002) and benign prostatic tissue (mean 15.7%, P = 0.034), but were similar to men with prostate cancer (mean 15.3%, P = 0.315).
  • This might explain the variability of f/tPSA in improving specificity when used as a screening tool for prostate cancer, and might also reduce its effectiveness in differentiating tumours with more aggressive potential.
  • [MeSH-major] Mass Screening / methods. Prostate-Specific Antigen / blood. Prostatic Neoplasms / diagnosis. Prostatitis / blood
  • [MeSH-minor] Acute Disease. Aged. Biopsy / methods. Cohort Studies. Humans. Incidental Findings. Male. Middle Aged. Prospective Studies. Prostate / pathology. Sensitivity and Specificity


3. Widder S, Guggisberg K, Khalil M, Pasieka JL: A pathologic re-review of follicular thyroid neoplasms: the impact of changing the threshold for the diagnosis of the follicular variant of papillary thyroid carcinoma. Surgery; 2008 Jul;144(1):80-5
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  • [Title] A pathologic re-review of follicular thyroid neoplasms: the impact of changing the threshold for the diagnosis of the follicular variant of papillary thyroid carcinoma.
  • The purpose was to determine whether, on review, these criteria would result in a change in diagnosis of follicular neoplasm (FN).
  • METHODS: A ten-year clinical cohort included patients with a diagnosis of a follicular adenoma, follicular carcinoma (FC), or FVPTC.
  • Clinical follow-up, including ultrasonography, was carried out on all patients with a change in diagnosis.
  • Initially, 118 were benign, 56 were FVPTC, and 11 were FC.
  • Overall, 46 (25%) patients had a change in diagnosis on re-review; 35 were reclassified from a benign diagnosis to a re-reviewed malignant diagnosis, with 5 reclassified as minimally invasive FC, 4 as occult PTC, and 26 (74%) as FVPTC.
  • None of these patients had evidence of recurrent or persistent disease.
  • Eleven patients were reclassified to a benign diagnosis.
  • A third independent thyroid pathologist also reviewed the histopathologic slides of these 46 patients and concurred with the change in diagnosis in 41 of the 46 patients.
  • Although there have been no clinical ramifications in the patients with a changed diagnosis, the ethical issues surrounding these 46 patients are important and present a substantive quandary to the clinicians responsible for their care.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Adenocarcinoma, Papillary / pathology. Diagnostic Errors / ethics. Ethics, Clinical. Thyroid Neoplasms / pathology
  • [MeSH-minor] Classification. Diagnosis, Differential. Humans


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4. Rybikowski S, Tomatis L, Arroua F, Ragni E, Rossi D, Bastide C: [Value of percutaneous kidney biopsy in the management of solid renal tumours less or equal to 4 cm]. Prog Urol; 2008 Jun;18(6):337-43
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  • [Title] [Value of percutaneous kidney biopsy in the management of solid renal tumours less or equal to 4 cm].
  • [Transliterated title] Intérêts des ponctions biopsies rénales percutanées dans la prise en charge des tumeurs solides du rein inférieures ou égales à 4 cm.
  • OBJECTIVE: To assess the value of diagnostic percutaneous kidney biopsy of solid renal tumours less or equal to 4 cm and its impact on management.
  • MATERIALS AND METHOD: From January 2001 to October 2006, all solid renal tumours less or equal to 4 cm were systematically assessed by CT-guided percutaneous biopsy: 66 tumours were biopsied in 65 patients (one bilateral tumour) and four patients had a second biopsy.
  • Four were repeated and provided a diagnosis in 50% of cases.
  • Two patients with non contributive biopsies were lost to follow-up.
  • Seven benign tumours (10.9%) and 54 malignant tumours were diagnosed.
  • The kidney biopsy diagnosed 91% (52/57) of malignant tumours and 57% (4/7) of benign tumours.
  • The concordance between biopsy results and pathology results was 90.7% for histological type of tumour and 64% for Fuhrman nuclear grade.
  • Histological type and tumour grade had no impact on the type of surgery performed (51 patients operated, 29 kidney-preserving procedures, by necessity in seven cases).
  • Four patients (6.3%) in whom a benign tumour was diagnosed on biopsy were simply followed, thereby avoiding surgery.
  • CONCLUSION: This series revealed 10.9% of benign tumours, only 57% of which were diagnosed by biopsy.
  • Kidney biopsy remains an option in the pretreatment assessment of renal tumours less or equal to 4 cm, but cannot be proposed systematically.
  • [MeSH-major] Biopsy / methods. Kidney / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 18558321.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] France
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5. Miyamoto H, Jones CE, Raymond DP, Wandtke JC, Strang JG, Bourne PA, Bonfiglio TA, Xu H: Pulmonary metastases from uterine neoplasms after long tumour-free interval: four cases and review of the literature. Pathology; 2009;41(3):234-41
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  • [Title] Pulmonary metastases from uterine neoplasms after long tumour-free interval: four cases and review of the literature.
  • AIMS: Uncommon cases of lung metastasis from different types of uterine neoplasms with a long tumour-free interval after hysterectomy are reported.
  • A transthoracic biopsy revealed benign metastasising leiomyoma.
  • The biopsied and resected lung tumour was consistent with metastatic EEA.
  • Case 4 was a 51-year-old woman who underwent total hysterectomy and subsequent radiotherapy for endocervical adenocarcinoma 12 years ago and lung lobectomy for metastatic disease 8 years ago.
  • CONCLUSIONS: A review of the literature revealed that late pulmonary metastasis from uterine neoplasms is rare but not negligible.
  • Immunohistochemical studies and molecular tests, together with detailed clinical information and imaging findings, are important for rendering a diagnosis.
  • [MeSH-major] Carcinoma, Endometrioid / secondary. Leiomyoma / pathology. Lung Neoplasms / secondary. Sarcoma, Endometrial Stromal / secondary. Uterine Neoplasms / pathology

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  • (PMID = 19291535.001).
  • [ISSN] 1465-3931
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 41
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6. Anurova OA, Snigur PV, Filippova NA, Sel'chuk VIu: [Morphological characteristics of stromal gastrointestinal tumors]. Arkh Patol; 2006 Jan-Feb;68(1):10-3
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  • [Title] [Morphological characteristics of stromal gastrointestinal tumors].
  • Stromal tumors are singled out from smooth muscle and neurogenic neoplasms into a special group due to differences in CD117 expression caused by mutation of c-kit gene.
  • Out of 57 stromal tumors, 37 (64,9%) located in the stomach, 17 (29,8%) in the small intestine and 3 (5,3%) in the colon.
  • Immunohistochemically, all the tumors expressed CD117 and vimentine.
  • Smooth muscle actin was found in 82% tumors, S-100 protein in 75%, neuron-specific enolase in 66% cases.
  • Malignant tumors were in 93% cases, and in 7% benign.
  • The liver was most frequent site of metastases (88.9%), peritoneum (51.9%).
  • 21% patients died of progression of the underlying disease during the follow-up of 6-60 months.
  • [MeSH-major] Gastrointestinal Stromal Tumors / metabolism. Gastrointestinal Stromal Tumors / pathology. Neoplasm Proteins / biosynthesis
  • [MeSH-minor] Female. Follow-Up Studies. Humans. Liver Neoplasms / metabolism. Liver Neoplasms / mortality. Liver Neoplasms / pathology. Liver Neoplasms / secondary. Male. Peritoneal Neoplasms / metabolism. Peritoneal Neoplasms / mortality. Peritoneal Neoplasms / pathology. Peritoneal Neoplasms / secondary. Stromal Cells / metabolism. Stromal Cells / pathology

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  • (PMID = 16544528.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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7. Radotra B, Awasthi A, Joshi K, Das A: Histopatholgical spectrum of thymic neoplasms: twelve-year experience at a referral hospital in north India. Indian J Pathol Microbiol; 2006 Jan;49(1):1-6
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  • [Title] Histopatholgical spectrum of thymic neoplasms: twelve-year experience at a referral hospital in north India.
  • This study was undertaken to determine the histopathological spectrum and clinical profile of thymic neoplasms at a tertiary referral care centre.
  • A total of 96 thymectomy specimens were received during the study period (1992-2004), which consisted of 54 neoplasms and 42 benign lesions.
  • Among the neoplasms there were 48 thymic epithelial tumors, 3 thymolipomas and 3 thymic carcinoids.
  • Among paraneoplastic syndromes in thymic epithelial tumours, 27 out of 48 (56.25%) cases were associated with myasthenia gravis and one case was associated with pure red cell aplasia.
  • This study has revealed that half of thymic epithelial tumours presented as myasthenia gravis.
  • [MeSH-major] Thymus Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Carcinoid Tumor / pathology. Carcinoma / pathology. Child. Child, Preschool. Female. Humans. India. Lipoma / pathology. Male. Middle Aged. Myasthenia Gravis. Neoplasm Staging. Red-Cell Aplasia, Pure. Thymectomy. Thymoma / pathology. Thymus Gland / pathology

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  • (PMID = 16625962.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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8. Sugawara Y, Kikuchi T, Kajihara M, Semba T, Ochi T, Fujii T, Mochizuki T, Sakayama K, Nakata S: Thallium-201 scintigraphy in bone and soft-tissue tumors: a comparison of dynamic, early and delayed scans. Ann Nucl Med; 2005 Sep;19(6):461-8
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  • [Title] Thallium-201 scintigraphy in bone and soft-tissue tumors: a comparison of dynamic, early and delayed scans.
  • OBJECTIVE: It has been reported that delayed scan of thallium-201 (201Tl) scintigraphy is useful for differentiating malignant tumors from benign lesions and for evaluating treatment response.
  • However, physiological muscle uptake which usually increases in delayed scans, often makes it difficult to evaluate 201Tl uptake and its washout in bone and soft-tissue tumors.
  • The purpose of this study was to evaluate whether the delayed scan is necessary and whether a dynamic scan is useful in the evaluation of bone and soft-tissue tumors.
  • METHODS: We studied 175 cases of bone and soft-tissue tumors (malignant 45, benign 130).
  • 201Tl images were visually interpreted and the radioactivity count ratio (T/N) of tumors to normal tissues and washout rate [WR = (early T/N - delayed T/N)/early T/N] were defined.
  • RESULTS: When there were no 201Tl uptake in dynamic (n = 67) and early scans (n = 68), no tumor uptake was also appreciated in delayed scans, and all but two cases of negative scans were benign.
  • In 107 lesions, although there were significant differences in T/Ns between malignant and benign lesions both on early scans (2.84 +/- 1.45 vs. 2.05 +/- 1.13, p < 0.05) and delayed scans (2.17 +/- 1.03 vs. 1.58 +/- 0.64, p < 0.05), there was a substantial overlap.
  • The T/Ns decreased in delayed scans (i.e., WR > 0) in 100 of 107 cases due to increase of surrounding muscle uptake, and there was no difference in WR between malignant tumors and benign lesions (0.21 +/- 0.14 vs. 0.19 +/- 0.14).
  • CONCLUSIONS: For evaluating bone and soft-tissue tumors, delayed scan had little clinical usefulness and it may be time consuming.
  • Dynamic scan would be useful for demonstrating the differences between tumor blood flow and 201Tl uptake in tumors.
  • [MeSH-major] Bone Neoplasms / radionuclide imaging. Image Enhancement / methods. Image Interpretation, Computer-Assisted / methods. Soft Tissue Neoplasms / radionuclide imaging. Thallium

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  • (PMID = 16248382.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Clinical Trial; Controlled Clinical Trial; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 7791-12-0 / thallium chloride; AD84R52XLF / Thallium
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9. Ruttenstock EM, Saxena AK, Schwinger W, Sorantin E, Hoellwarth ME: Pediatric ovarian tumors--dilemmas in diagnosis and management. Eur J Pediatr Surg; 2010 Mar;20(2):116-20
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  • [Title] Pediatric ovarian tumors--dilemmas in diagnosis and management.
  • BACKGROUND: Ovarian tumors are rare in the pediatric age group and thus diagnostic and treatment strategies are heterogeneous.
  • This study aims to evaluate ovarian tumors with a focus on age at presentation, imaging characteristics, diagnostic strategy, tumor presentation and management.
  • METHODS: Data was collected retrospectively from patients admitted between 1991 and 2008 for the evaluation and therapy of ovarian tumors.
  • RESULTS: Twenty-five patients were identified with neoplastic ovarian lesions (mean age 10.7 years).
  • Sixteen patients (64%) underwent surgery for benign and 9 (36%) for malignant tumors.
  • Benign tumors (n=16) had a mean diameter of 10.7 cm and mean age at presentation was 9.6 years compared to a diameter of 18.6 cm and 12.3 years in the malignant group (n=9).
  • Elevated tumor markers were observed in 3 (12.5%) benign tumors and in 7 (77.8%) malignant tumors.
  • In preoperative ultrasound investigation, cyst formation was identified in 4 benign tumors and solid tumor mass in 2 malignant tumors.
  • CONCLUSION: Cyst formation, small tumor size and younger age at presentation were characteristic of benign tumors.
  • Malignant tumors often presented with elevated tumor markers, a larger size and a solid consistency.
  • Diagnostic dilemmas remain for both tumor groups due to the different tumor types and the heterogeneity of presentation.
  • [MeSH-major] Ovarian Neoplasms / pathology. Ovarian Neoplasms / surgery
  • [MeSH-minor] Child. Female. Humans. Neoplasm Staging. Retrospective Studies

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  • (PMID = 20112185.001).
  • [ISSN] 1439-359X
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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10. Rocourt DV, Shiels WE, Hammond S, Besner GE: Contemporary management of benign hepatic adenoma using percutaneous radiofrequency ablation. J Pediatr Surg; 2006 Jun;41(6):1149-52
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  • [Title] Contemporary management of benign hepatic adenoma using percutaneous radiofrequency ablation.
  • Hepatic adenoma is a benign liver tumor that occurs primarily in women.
  • The authors present an unusual case report of a histologically proven benign hepatic adenoma occurring in an adolescent boy treated with percutaneous radiofrequency ablation (RFA).
  • Magnetic resonance imaging scan revealed a lobular solid mass in the posterior segment of the right lobe of the liver that did not have the classic appearance of a hemangioma.
  • Histologic examination revealed a benign liver adenoma.
  • The tumor was treated with RFA by the interventional radiologist.
  • Postprocedure computed tomography scans obtained at 6 weeks, 8 months, and 1 year and magnetic resonance imaging scan obtained 2 years after the procedure showed complete ablation of the tumor with no evidence of tumor recurrence.
  • Traditionally, surgical resection has been the mainstay of therapy for the treatment of benign hepatic adenoma.
  • [MeSH-major] Adenoma / surgery. Catheter Ablation. Liver Neoplasms / surgery

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  • (PMID = 16769351.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Giorgi Rossi P, Chini F, Barca A, Baiocchi D, Federici A, Farchi S, Borgia P: Efficacy of disease management profiles. The mammographic screening program of Lazio. Tumori; 2008 May-Jun;94(3):297-303
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  • [Title] Efficacy of disease management profiles. The mammographic screening program of Lazio.
  • BACKGROUND: Screening programs are considered disease management profiles.
  • Screening histories of all the incident cases of women surgically treated for a breast neoplasm were reconstructed (not contacted, contacted, non-participants, participants).
  • RESULTS: We identified 3251 women who were treated for malignant neoplasms of the breast and 1562 treated for benign neoplasms.
  • The incidence of malignant neoplasms was higher in the women contacted for screening (incidence rate ratio, 1.45; 95% CI, 1.32-1.60), and the incidence of treatment for non-malignancies was similar in the two populations (incidence rate ratio, 1.00: 95% CI, 0.86-1.16).
  • The percentage of surgery for non-malignancies detected by screening was 16.7%, whereas among the cases diagnosed outside a screening program it was 33.8%.
  • Women contacted for screening showed a higher incidence of localized and in situ tumors, whereas the incidence of non-localized and metastatic tumors was basically the same in the two groups.
  • CONCLUSIONS: The first round of screening programs led to more surgical interventions, a similar incidence of mastectomy and of interventions for benign neoplasm, but a lower incidence of unnecessary treatment.
  • [MeSH-major] Breast Neoplasms / diagnostic imaging. Breast Neoplasms / surgery. Mammography. Mass Screening. Mastectomy / methods
  • [MeSH-minor] Aged. Carcinoma in Situ / diagnostic imaging. Carcinoma in Situ / surgery. Early Diagnosis. Female. Humans. Incidence. Italy / epidemiology. Middle Aged. Neoplasm Staging. Odds Ratio. Program Evaluation. Research Design

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  • (PMID = 18705394.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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12. Lenhard MS, Kahlert S, Himsl I, Ditsch N, Untch M, Bauerfeind I: Phyllodes tumour of the breast: clinical follow-up of 33 cases of this rare disease. Eur J Obstet Gynecol Reprod Biol; 2008 Jun;138(2):217-21
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  • [Title] Phyllodes tumour of the breast: clinical follow-up of 33 cases of this rare disease.
  • OBJECTIVE: The "cystosarcoma phyllodes" of the breast is a rare entity which accounts for 0.5% of all breast neoplasms.
  • STUDY DESIGN: The data of 5270 patients with primary breast neoplasms treated in our department between 1984 and 2005 were retrospectively analysed for the histopathologic diagnosis of a cystosarcoma phyllodes.
  • The clinical data was analysed with respect to tumour grading and size, treatment and prognosis.
  • RESULTS: Retrospective analysis of 5270 patients with primary breast neoplasms revealed 33 patients.
  • In the histopathological analysis, tumour grade was classified as benign in 40%, borderline in 27% and malignant in 33% of patients.
  • Mean tumour size was 6.9 cm, and no lymph node infiltration was found in the 10 patients who received axillary lymph node dissection.
  • The local recurrence rate was 50% in malignant, 20% in borderline and only 8% in benign tumours.
  • Distant metastases were seen in three patients (9%) with malignant phyllodes tumours.
  • Neither regarding age at primary diagnosis nor in tumour size there was a significant difference between patients with local recurrence or metastatic spread and those without (p=0.284 tumour size; p=0.739 for age; Mann-Whitney U-test).
  • CONCLUSION: Histopathological classification appears to be the strongest prognostic factor in this disease.
  • [MeSH-major] Breast Neoplasms / pathology. Phyllodes Tumor / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Middle Aged. Neoplasm Recurrence, Local. Rare Diseases. Retrospective Studies

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  • (PMID = 17868973.001).
  • [ISSN] 0301-2115
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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13. Zhang CF, Dong FT, Chen YX, Du H, Han BL: [Clinical manifestation and follow-up of melanocytoma of the optic disc]. Zhonghua Yan Ke Za Zhi; 2009 Apr;45(4):296-300
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  • The examination included direct and indirect ophthalmoscopy, fundus photography, fundus fluorescein angiography (FFA), fundus indocyanine green angiography (ICGA), optical coherence tomography (OCT) and B-scan.
  • The tumor mass at the optic disc with extensive serous detachment of retina was detected on B-scan in one eye.
  • The benign melanocytoma was diagnosed by vitreous fine needle biopsy for this eye.
  • In other case, the tumor was found to be enlarged, visual field defect deteriorated, pigment granules appeared in the vitreous adjacent to the tumor during on year follow-up period.
  • On the patient request, enucleation was performed to rule out the malignancy of the tumor.
  • Pathologic study showed that the tumor cells were active, but benign state.
  • The tumor size and visual acuity in other eight eyes remained stable in the follow-up period with one to 18 years (mean 3.5 years).
  • CONCLUSIONS: Melanocytoma of the optic disc is a benign tumor that rarely causes visual impairment.
  • However, visual acuity may be impaired due to enlargement of the tumor or necrosis in tumor.
  • [MeSH-major] Melanoma / diagnosis. Optic Disk / pathology. Optic Nerve Neoplasms / diagnosis
  • [MeSH-minor] Adult. Choroid Neoplasms / diagnosis. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 19575959.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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14. Choi SW, Song SH: Intrapelvic lipoblastoma with massive spinal canal invasion. Childs Nerv Syst; 2007 May;23(5):581-5
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  • OBJECTS: The lipoblastoma is a rare benign pediatric neoplasm that derives from embryonic white fat cells.
  • However, this tumor with spinal invasion in children is extremely rare.
  • We report a case of a 3-year-old boy who had lipoblastoma with massive invasion into the lower lumbosacral spinal canal.
  • Histopathologic diagnosis confirmed the lipoblastoma.
  • CONCLUSION: Lipoblastoma is a rare benign neoplasm and lumbosacral invasion is unique.
  • [MeSH-major] Lipoma / pathology. Neoplasms, Adipose Tissue / pathology. Pelvic Neoplasms / pathology. Spinal Cord Neoplasms / secondary

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  • [Cites] Pediatr Surg Int. 2000;16(5-6):458-61 [10955594.001]
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  • (PMID = 17143644.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Coloring Agents
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15. Masarie K, Katz V, Balderston K: Pregnancy luteomas: clinical presentations and management strategies. Obstet Gynecol Surv; 2010 Sep;65(9):575-82
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  • Pregnancy luteomas are rare, benign, neoplasms of the ovary thought to be caused by the hormonal effects of pregnancy.
  • We present a case of a woman with the classic presentation of a pregnancy luteoma and the common challenges of subsequent management.
  • Pregnancy luteomas present a diagnostic and management challenge in that they can mimic the presentation of malignant ovarian tumors.
  • There have been fewer than 200 case reports of pregnancy luteomas and a relative paucity of data to provide guidance for clinical management.
  • When there is a high clinical suspicion for pregnancy luteoma, conservative management is appropriate since these tumors will usually regress spontaneously.
  • After completing this CME activity, obstetrician/gynecologists should be better able to evaluate clinical presentations of pregnancy luteomas, examine the complexities involved in diagnosing neoplasms suspicious for pregnancy luteoma, and counsel patients about appropriate management and treatment options.
  • TARGET AUDIENCE: Obstetricians & Gynecologists, Family Physicians, Pediatricians Learning Objectives: After completion of this article, the reader should be better able to evaluate the clinical presentations of pregnancy luteomas; examine the complexities involved in the diagnosis of neoplasms suspicious for pregnancy luteoma; and counsel patients on appropriate management and treatment for suspected luteomas.
  • [MeSH-major] Luteoma / diagnosis. Luteoma / therapy. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / therapy. Pregnancy Complications, Neoplastic / diagnosis. Pregnancy Complications, Neoplastic / therapy
  • [MeSH-minor] Adult. Cesarean Section. Diagnosis, Differential. Female. Humans. Ovariectomy. Pregnancy. Virilism / etiology

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  • (PMID = 21144088.001).
  • [ISSN] 1533-9866
  • [Journal-full-title] Obstetrical & gynecological survey
  • [ISO-abbreviation] Obstet Gynecol Surv
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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16. Biber R: [Benign metastasizing leiomyoma of the lung]. MMW Fortschr Med; 2009 Jun 25;151(26-29):46-7
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  • [Title] [Benign metastasizing leiomyoma of the lung].
  • [MeSH-major] Leiomyoma. Lung Neoplasms / secondary. Uterine Neoplasms
  • [MeSH-minor] Angiomyoma / diagnosis. Female. Humans. Lymph Node Excision. Middle Aged. Radiography, Thoracic. Risk Factors. Solitary Pulmonary Nodule / diagnosis. Thoracoscopy. Thoracotomy. Time Factors

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  • (PMID = 19739550.001).
  • [ISSN] 1438-3276
  • [Journal-full-title] MMW Fortschritte der Medizin
  • [ISO-abbreviation] MMW Fortschr Med
  • [Language] ger
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 0
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17. La Vecchia C, Tavani A: Female hormones and benign liver tumours. Dig Liver Dis; 2006 Aug;38(8):535-6
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  • [Title] Female hormones and benign liver tumours.
  • [MeSH-major] Contraceptives, Oral, Hormonal / adverse effects. Liver Neoplasms / chemically induced

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  • (PMID = 16753350.001).
  • [ISSN] 1590-8658
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Contraceptives, Oral, Hormonal
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18. Doganavsargil B, Simsir A, Boyacioglu H, Cal C, Hekimgil M: A comparison of p21 and p27 immunoexpression in benign glands, prostatic intraepithelial neoplasia and prostate adenocarcinoma. BJU Int; 2006 Mar;97(3):644-8
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  • [Title] A comparison of p21 and p27 immunoexpression in benign glands, prostatic intraepithelial neoplasia and prostate adenocarcinoma.
  • OBJECTIVE: To assess the immunoexpression of p21 and p27 proteins in consecutive areas of benign glands, prostatic intraepithelial neoplasia (PIN) and prostate adenocarcinoma.
  • PATIENTS AND METHODS: Tissue from 91 patients who had a radical prostatectomy was assessed by immunohistochemistry to evaluate the expression of p21 and p27 in adjacent areas of benign glands, PIN and prostate adenocarcinoma.
  • The results were correlated with various clinicopathological variables, e.g. age, total prostate-specific antigen level, tumour stage, Gleason score, surgical margin involvement, extraprostatic extension, seminal vesicle invasion, and perineural invasion.
  • RESULTS: The p27 score in PIN was lower than that in benign glands (P = 0.04) but there was no significant difference between the scores for PIN and tumour.
  • By contrast, p21 expression was almost undetectable in benign glands, although there was substantially more in PIN and tumour (P < 0.01).
  • Some patients had no expression of p21 in tumour tissue, and had lower p21 scores in benign glands and PIN areas (P < 0.05).
  • The tumour p21 score was higher in patients with extraprostatic extension (P = 0.045) and tumour p27 expression was inversely correlated with seminal vesicle invasion (P = 0.028).
  • Tumour and PIN p27 expression appeared to decrease with advancing age (P = 0.008 and 0.012, respectively).
  • The decline in p27 with advancing age in tumour and PIN areas may be a possible explanation of the greater frequency of prostate adenocarcinoma in older men.
  • A p21-negative tumour subgroup with a lower frequency of adverse prognostic factors was identified, which needs to be further explored.
  • [MeSH-major] Adenocarcinoma / chemistry. Cyclin-Dependent Kinase Inhibitor p21 / analysis. Cyclin-Dependent Kinase Inhibitor p27 / analysis. Neoplasm Proteins / analysis. Prostatic Intraepithelial Neoplasia / chemistry. Prostatic Neoplasms / chemistry

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  • (PMID = 16469041.001).
  • [ISSN] 1464-4096
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Neoplasm Proteins; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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19. Juhlin J: [Surgery on cylindroma of the external auditory canal]. Ugeskr Laeger; 2009 Nov 2;171(45):3280-2
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  • Cylindromas are rare benign tumours arising from sweat glands in the skin.
  • They occur as multiple tumours (as in Brooke-Spieglers syndrome) and solitary tumours.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Ear Canal / surgery. Ear Neoplasms / surgery. Neoplasms, Multiple Primary / surgery. Otologic Surgical Procedures / methods. Skin Neoplasms / surgery
  • [MeSH-minor] Female. Head and Neck Neoplasms / surgery. Humans. Middle Aged. Scalp / pathology

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  • (PMID = 19887058.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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20. Christensen N, Canfield P, Martin P, Krockenberger M, Spielman D, Bosward K: Cytopathological and histopathological diagnosis of canine splenic disorders. Aust Vet J; 2009 May;87(5):175-81
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  • [Title] Cytopathological and histopathological diagnosis of canine splenic disorders.
  • OBJECTIVES: To determine (1) the common types of canine splenic disorders, and the breeds affected, that are diagnosed by cytopathological and histopathological examination in Sydney, Australia and (2) the accuracy of cytopathological examination compared with histopathological examination for the diagnosis of canine splenic disorders.
  • RESULTS: The most common cytopathological diagnoses were benign disorders of growth, vascular disturbances and necrosis (29%), followed by no abnormalities detectable (28%), malignant neoplasms (20%), equivocal diagnoses (20%) and inflammatory disorders (3%).
  • The most common histopathological diagnoses were benign disorders of growth, vascular disturbances and necrosis (49%), followed by malignant neoplasms (43%) and inflammatory disorders (8%).
  • CONCLUSION: Benign disorders of growth, vascular disturbances and necrosis were the most commonly diagnosed canine splenic disorders, both cytopathologically and histopathologically.
  • Although cytopathological and histopathological splenic examinations are complementary for diagnosis, this study has shown a high correlation for complete and partial agreement between the two.

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  • (PMID = 19382924.001).
  • [ISSN] 0005-0423
  • [Journal-full-title] Australian veterinary journal
  • [ISO-abbreviation] Aust. Vet. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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21. Sturgeon BP, Milne EM, Smith KC: Benign peripheral nerve sheath tumor of the perianal region in a young pony. J Vet Diagn Invest; 2008 Jan;20(1):93-6
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  • [Title] Benign peripheral nerve sheath tumor of the perianal region in a young pony.
  • A 20 x 10 cm, lobulated mass was present in the perianal region of a 4-year-old Dales pony.
  • The whorls were often arranged around a central structure resembling an axon or a vascular structure.
  • On the basis of the histopathology and immunohistochemistry, a diagnosis of benign peripheral nerve sheath tumor (schwannoma type) was made.
  • This case was unusual in that the concentric laminations of Schwann cells were very loosely arranged, with an intervening myxomatous stroma (Antoni type B appearance) and despite its benign histological appearance, the mass extended deeply to the proximal sacral vertebrae.
  • [MeSH-major] Anus Neoplasms / veterinary. Horse Diseases / pathology. Nerve Sheath Neoplasms / veterinary
  • [MeSH-minor] Animals. Horses. Immunohistochemistry / veterinary. Male. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / veterinary

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  • (PMID = 18182519.001).
  • [ISSN] 1040-6387
  • [Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • [ISO-abbreviation] J. Vet. Diagn. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Hsiao YH, Huang YL, Kuo SJ, Liang WM, Chen ST, Chen DR: Characterization of benign and malignant solid breast masses in harmonic 3D power Doppler imaging. Eur J Radiol; 2009 Jul;71(1):89-95
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  • [Title] Characterization of benign and malignant solid breast masses in harmonic 3D power Doppler imaging.
  • PURPOSE: The authors assessed the characteristics of benign and malignant solid breast tumors in harmonic three-dimensional (3D) power Doppler imaging and proposed decision models to classify benign and malignant breast tumors.
  • MATERIALS AND METHODS: A total of 86 malignant and 97 benign harmonic 3D power Doppler US images were analyzed.
  • All the harmonic 3D power Doppler images were obtained using a Voluson730 US system (GE, Zipf, Austria) equipped with a RSP 6-12 transducer and tissue harmonic imaging modalities.
  • Histogram indices, the vascularization index (VI), flow index (FI) and vascularization-flow index (VFI), were calculated for the intra-tumor and for shells with an outside thickness of 3mm surrounding the breast tumors.
  • RESULTS: The results revealed that the choice of decision model comprised the parameters of patient age, intra-tumor VI, and tumor volume to classify benign and malignant breast tumors.
  • The parameter intra-tumor VI was the choice for all of the histogram indices in differentiating between malignant and benign lesions.
  • CONCLUSION: The decision model, which was composed of patient age, tumor volume and intra-tumor VI, and a cut-off value for intra-tumor VI at the upper end of patient age and tumor volume, was recommended in clinical application.
  • [MeSH-major] Breast Neoplasms / ultrasonography. Imaging, Three-Dimensional / methods. Ultrasonography, Doppler / methods. Ultrasonography, Mammary / methods

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  • (PMID = 18479868.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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23. Grenacher L, Klauss M: [Computed tomography of pancreatic tumors]. Radiologe; 2009 Feb;49(2):107-23
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  • [Title] [Computed tomography of pancreatic tumors].
  • Computed tomography (CT) and in particular multi-detector row computed tomography (MDCT), also known as multislice CT (MSCT), is ideally suited for detecting pancreatic tumors because of the high spatial resolution.The method of choice is hydro-CT which involves distension of the stomach and duodenum by administration of 1-1.5 l water as a negative contrast medium under medically induced hypotension by administration of buscopan.
  • In addition, curved MPRs or in rare cases 3D reconstructions could be very helpful in identifying the critical anatomic tumor site in the neighbourhood of the visceral vessel system.
  • After the correct diagnosis of an adenocarcinoma has been made only 20% of all patients are shown to have a surgically resectable disease, but the overall survival rate is significantly higher after resection in combination with a multimodal tumor therapy strategy.
  • The reason is that the correct diagnosis of the resectability of the tumor is one of the main criteria for overall survival of these patients.
  • Currently practically all pancreatic tumors can be detected using MDCT and the detection rate varies between 70% and 100% (most recent literature references give a sensitivity of 89% and specificity up to 99%).
  • Resectability can be correctly diagnosed with MDCT with a sensitivity of 94% and a specificity of 89%.
  • MDCT is an ideal tool for the detection of neuroendocrine tumors, metastases and for the differentiation of cystic pancreatic lesions such as pseudocysts, microcystic adenomas or intraductal papillary mucinous neoplasms (IPMN).
  • Particularly, the differentiation of the latter into benign, borderline or malignant transformation is not always possible, but indirect signs, such as small nodules adjacent to the ductal wall, the diameter of the pancreatic duct, or a direct communication between cystic lesions and duct can be detected because of the high spatial resolution and is comparable to the findings in MRI.
  • Moreover MD-CT is an ideal procedure for the differentiation of local tumor stages in patients under neoadjuvant or adjuvant chemotherapy.
  • [MeSH-major] Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Pancreatic Neoplasms / diagnostic imaging. Tomography, Spiral Computed
  • [MeSH-minor] Adenocarcinoma / diagnostic imaging. Adenocarcinoma / mortality. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adenocarcinoma, Mucinous / diagnostic imaging. Adenocarcinoma, Mucinous / mortality. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / surgery. Carcinoma, Pancreatic Ductal / diagnostic imaging. Carcinoma, Pancreatic Ductal / mortality. Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Pancreatic Ductal / surgery. Carcinoma, Papillary / diagnostic imaging. Carcinoma, Papillary / mortality. Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Diagnosis, Differential. Disease-Free Survival. Humans. Neuroendocrine Tumors / diagnostic imaging. Neuroendocrine Tumors / mortality. Neuroendocrine Tumors / pathology. Neuroendocrine Tumors / surgery. Pancreas / diagnostic imaging. Pancreas / pathology. Pancreatectomy. Pancreatic Pseudocyst / diagnostic imaging. Prognosis. Sensitivity and Specificity

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  • (PMID = 19137277.001).
  • [ISSN] 1432-2102
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 71
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24. Brustmann H: Immunohistochemical detection of human telomerase reverse transcriptase (hTERT) and c-kit in serous ovarian carcinoma: a clinicopathologic study. Gynecol Oncol; 2005 Sep;98(3):396-402
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  • [Title] Immunohistochemical detection of human telomerase reverse transcriptase (hTERT) and c-kit in serous ovarian carcinoma: a clinicopathologic study.
  • OBJECTIVE: This study investigated the expression of human telomerase reverse transcriptase (hTERT) and c-kit in a cohort of serous ovarian carcinomas by immunohistochemistry with regard to outcome and clinicopathologic variables.
  • METHODS: Formalin-fixed, paraffin-embedded archival tissue sections of 10 benign serous cystadenomas, 10 serous neoplasms of low malignant potential (LMP), and 41 serous ovarian carcinomas were immunostained with antibodies to hTERT and c-kit.
  • No c-kit immunoreactivity was observed in serous cystadenomas and LMP; 27% of serous carcinomas were negative, 46% showed moderate, and 27% strong immunostaining. c-kit immunoreactivity was positively correlated with grade (P = 0.0008) and FIGO stage (P = 0.0247), but not with mitotic activity (P = 0.1433) and outcome (P = 0.1145); however, c-kit expression was positively related with poor outcome in FIGO II and III stages (P = 0.0105).
  • CONCLUSIONS: hTERT and c-kit are frequently up-regulated in serous ovarian carcinomas; c-kit immunoexpression may serve as a marker of aggressive behavior in high stage tumors.
  • [MeSH-major] Biomarkers, Tumor / biosynthesis. Cystadenocarcinoma, Serous / enzymology. DNA-Binding Proteins / biosynthesis. Ovarian Neoplasms / enzymology. Proto-Oncogene Proteins c-kit / biosynthesis. Telomerase / biosynthesis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Growth Processes / physiology. Female. Humans. Immunohistochemistry. Middle Aged. Mitosis / physiology. Neoplasm Staging. Prognosis. Survival Rate

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  • (PMID = 16005054.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.7.49 / Telomerase
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25. Terry G, Ho L, Londesborough P, Duggan C, Hanby A, Cuzick J: The expression of FHIT, PCNA and EGFR in benign and malignant breast lesions. Br J Cancer; 2007 Jan 15;96(1):110-7
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  • [Title] The expression of FHIT, PCNA and EGFR in benign and malignant breast lesions.
  • Immunohistochemical staining for FHIT and PCNA proteins was carried out in 451 breast lesions showing nonproliferative benign breast disease (BBD) (n=263), proliferative BBD without atypia (n=128), proliferative BBD with atypia (n=11), carcinoma in situ (n=15) or invasive carcinoma (n=34) and for EGFR protein in a subset of 71 of these cases.
  • [MeSH-major] Acid Anhydride Hydrolases / biosynthesis. Breast Diseases / metabolism. Breast Neoplasms / metabolism. Carcinoma, Ductal, Breast / metabolism. Carcinoma, Intraductal, Noninfiltrating / metabolism. Neoplasm Proteins / biosynthesis. Proliferating Cell Nuclear Antigen / biosynthesis. Receptor, Epidermal Growth Factor / biosynthesis
  • [MeSH-minor] Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Oligonucleotide Array Sequence Analysis / methods. Polymerase Chain Reaction / methods. RNA / genetics. Sensitivity and Specificity. Staining and Labeling


26. Chen ZW, Saad RS: Ovarian adenosarcoma arising from benign cystadenoma and associated intraoperative consultation pitfalls. Int J Gynecol Pathol; 2010 Sep;29(5):415-8
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  • [Title] Ovarian adenosarcoma arising from benign cystadenoma and associated intraoperative consultation pitfalls.
  • The malignant component was underdiagnosed during frozen section examination as benign cystadenoma because of the deceptively benign gross appearance of the tumor.
  • On the permanent sections, a phyllodes-like pattern of stromal proliferation and periglandular condensation of atypical stromal cells with a mitotic count of 3 per 10 high-power fields was more apparent and led to the diagnosis of adenosarcoma.
  • The malignant component could not be distinguished from the benign component using immunohistochemical analysis.
  • To our knowledge, this is the first reported case of an adenosarcoma arising from a grossly benign cystadenoma and the third case in the literature of an adenosarcoma associated with a cystadeno(fibro)ma.
  • This case also shows the challenges in differentiating adenosarcoma from a benign counterpart on both frozen and permanent sections.
  • [MeSH-major] Adenosarcoma / pathology. Cystadenoma / pathology. Neoplasms, Multiple Primary / pathology. Ovarian Neoplasms / pathology

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  • (PMID = 20736764.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Simeonov R, Simeonova G: Computerized cytomorphometric analysis of nuclear area, nuclear perimeter and mean nuclear diameter in spontaneous canine mammary gland tumours. Vet Res Commun; 2007 Jul;31(5):553-8
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  • [Title] Computerized cytomorphometric analysis of nuclear area, nuclear perimeter and mean nuclear diameter in spontaneous canine mammary gland tumours.
  • Fifty-two spontaneous canine mammary gland tumours (fibroadenomas (n=8), tubulopapillary carcinomas (n=9), solid carcinomas (n=6), anaplastic carcinomas (n=7), fibrosarcomas (n=9), liposarcomas (n=9) and osteosarcomas (n=4) were analysed by computer-assisted nuclear morphometry in Hemacolor-stained cytological specimens.
  • Computerized cytomorphometry was performed and the nuclear area, nuclear perimeter and mean nuclear diameter of investigated tumours were assessed.
  • The statistical analysis revealed statistically significant differences between benign and malignant neoplasms.
  • The results indicated that computer-assisted nuclear morphometry could be used as an additional method for differentiation of benign from malignant canine mammary gland tumours in cytological specimens.
  • [MeSH-major] Cell Nucleus. Cytological Techniques / veterinary. Dog Diseases / pathology. Histological Techniques / veterinary. Mammary Neoplasms, Animal / pathology

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  • (PMID = 17221362.001).
  • [ISSN] 0165-7380
  • [Journal-full-title] Veterinary research communications
  • [ISO-abbreviation] Vet. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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28. Meuris B, Gewillig M, Meyns B: Extreme levels of alpha-fetoprotein in a newborn with a benign intrapericardial teratoma. Cardiol Young; 2006 Feb;16(1):76-7
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  • [Title] Extreme levels of alpha-fetoprotein in a newborn with a benign intrapericardial teratoma.
  • We report a neonate presenting with an intrapericardial benign teratoma and an exceptionally high level of alpha-fetoprotein.
  • Such severe elevation of alpha-fetoprotein in a neonate with a teratoma is usually associated with the presence of immature or malignant elements, compromising the prognosis.
  • The tumour in our patient, however, proved to be completely benign.
  • [MeSH-major] Biomarkers, Tumor / blood. Heart Neoplasms / blood. Pericardium. Teratoma / blood. alpha-Fetoproteins / metabolism

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  • (PMID = 16454881.001).
  • [ISSN] 1047-9511
  • [Journal-full-title] Cardiology in the young
  • [ISO-abbreviation] Cardiol Young
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins
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29. Ramírez-Backhaus M, Trassierra M, Pontones JL, Luján S, DiCapua C, Rabenalt R, Stolzenburg JU, Jiménez Cruz F: [Significance of residual hyperplastic cells after radical prostatectomy. A literature review]. Actas Urol Esp; 2008 Oct;32(9):873-8
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  • [Transliterated title] Trascendencia de células hiperplásicas residuales a la prostatectomía radical. Revisión de la literatura.
  • We reviewed the literature looking for the incidence, the potential etiology and the influence of these hyperplastic cells in the biochemical evolution of the disease.
  • We used "Mesh", Prostatectomy" and "Prostatic Neoplasms" and "Prostate-Specific Antigen" terms, and we added "biochemical failure" and/or "hyperplasic cells" and/or "benign cells".
  • CONCLUSIONS: Benign hyperplasic cells left behind after radical prostatectomy are frequent and probably under-rated.
  • Positive margins for benign cells can come from apex or neck of the bladder, where the prostatic capsule is not well defined, but no from dorso-lateral area, this would imply a technical mistake.
  • [MeSH-major] Prostate / pathology. Prostatic Neoplasms / pathology. Prostatic Neoplasms / surgery

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  • (PMID = 19044296.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 33
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30. Han MW, Lee BJ, Jang YJ, Chung YS: Clinical value of office-based endoscopic incisional biopsy in diagnosis of nasal cavity masses. Otolaryngol Head Neck Surg; 2010 Sep;143(3):341-7
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  • [Title] Clinical value of office-based endoscopic incisional biopsy in diagnosis of nasal cavity masses.
  • SUBJECTS AND METHODS: From January 1997 to August 2006, preoperative diagnosis was achieved using endoscopic incisional biopsy in 521 patients.
  • Cytopathologic and histologic findings were categorized as malignancy, benign neoplasm, or non-neoplastic lesion.
  • We investigated the accuracy of endoscopic incisional biopsy and preoperative imaging by comparing it with pathologic results from tumor resection as the "gold standard."
  • RESULTS: Most of the patients had unilateral nasal symptoms (e.g., nasal obstruction, unilateral epistaxis, unilateral facial pain), and the clinical symptoms were of little diagnostic value in the differentiation of tumor and inflammatory lesion.
  • The sensitivity and specificity of endoscopic incisional biopsy were 43.7 and 98.9 percent, respectively, for the diagnosis of nasal cavity malignancies, and 78.2 and 96.2 percent, respectively, for the diagnosis of benign neoplasms.
  • The sensitivity and specificity of preoperative imaging were 78.3 and 97.5 percent, respectively, for the diagnosis of nasal cavity malignancies and 66.4 and 86.3 percent, respectively, for the diagnosis of benign neoplasms.
  • CONCLUSION: Endoscopic incisional biopsy alone did not ensure accurate diagnosis of nasal cavity tumors, but in combination with preoperative imaging it was helpful for the diagnosis of nasal cavity malignancies.
  • [MeSH-major] Ambulatory Surgical Procedures. Biopsy / methods. Endoscopy. Nasal Cavity. Nose Neoplasms / pathology

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  • [Copyright] Copyright 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20723769.001).
  • [ISSN] 1097-6817
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Blitman NM, Levsky JM, Villanueva-Siles E, Thornhill BA: Spontaneous hemorrhage simulating rapid growth of a benign subperiosteal plexiform neurofibroma. Pediatr Radiol; 2007 Sep;37(9):925-8
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  • [Title] Spontaneous hemorrhage simulating rapid growth of a benign subperiosteal plexiform neurofibroma.
  • Spontaneous subperiosteal hemorrhage is a rare complication of von Recklinghausen's disease.
  • Surgery and pathology revealed subperiosteal hemorrhage into a benign, plexiform neurofibroma.
  • Recognition of this disease process and differentiating it from malignant transformation can prevent unnecessary surgery.
  • [MeSH-major] Bone Neoplasms / diagnosis. Hemorrhage / diagnosis. Magnetic Resonance Imaging. Neurofibroma, Plexiform / diagnosis. Periosteum / blood supply. Periosteum / pathology
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Humans


32. Suardi N, Scattoni V, Briganti A, Salonia A, Naspro R, Gallina A, Cestari A, Colombo R, Karakiewicz PI, Guazzoni G, Rigatti P, Montorsi F: Nerve-sparing radical retropubic prostatectomy in patients previously submitted to holmium laser enucleation of the prostate for bladder outlet obstruction due to benign prostatic enlargement. Eur Urol; 2008 Jun;53(6):1180-5
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  • [Title] Nerve-sparing radical retropubic prostatectomy in patients previously submitted to holmium laser enucleation of the prostate for bladder outlet obstruction due to benign prostatic enlargement.
  • OBJECTIVES: To evaluate the feasibility and safety of nerve-sparing radical retropubic prostatectomy (NSRRP) for localised prostate cancer after holmium laser enucleation of the prostate (HoLEP) for bladder outlet obstruction due to benign prostatic enlargement (BPE).
  • RESULTS: At diagnosis, the prostate-specific antigen (PSA) level, clinical stage, Gleason sum distributions, body mass index, ICIQ-SF, and IPSS were not significantly different among the groups.
  • [MeSH-major] Laser Therapy. Lasers, Solid-State. Prostatectomy / methods. Prostatic Hyperplasia / complications. Prostatic Hyperplasia / surgery. Prostatic Neoplasms / surgery. Urinary Bladder Neck Obstruction / etiology. Urinary Bladder Neck Obstruction / surgery


33. Abdelkrim SB, Trabelsi A, Bouzrara M, Boudagga MZ, Memmi A, Bakir DA, Mokni M: Phyllodes Tumors of the Breast: A Review of 26 Cases. World J Oncol; 2010 Jun;1(3):129-134
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  • [Title] Phyllodes Tumors of the Breast: A Review of 26 Cases.
  • Background: Phyllodes tumors of the breast are rare and locally aggressive neoplasms.
  • Methods: The authors analyzed retrospectively clinical, radiological, histopathological and therapeutic features as well as outcome in a series of 26 cases diagnosed as phyllodes tumors of the breast at the Pathology Department of Farhat Hached Hospital, Sousse, Tunisia, from 2003 to 2009.
  • The slides were reviewed in order to classify the tumors into benign, borderline and malignant on the basis of the criteria proposed by the World Health Organization.
  • The analysis of this series showed the following characteristics: mean age at diagnosis was 40 years (19 - 66), tumor size was 1.5 - 40 cm (mean: 7.8 cm); the chief complaint was a mammary mass; the right breast was affected in 14 cases, the upper outer quadrant was the most commonly involved site (42.3%); surgical treatment was used in all cases, 21 patients (80.8%) were treated conservatively (13 benign, 6 borderline, and 2 malignant) and 5 (19.2%) by radical surgery (1 borderline and 4 malignant); seven patients underwent post-operative radiotherapy; in 14/19 cases (73.7%), a good correlation was observed between intraoperative frozen section analysis and definitive histology; the tumor was classed as benign in 13 cases (50%), borderline in 7 cases (27%) and malignant in 6 cases (23%); follow-up data was available in 22 cases; the rate of recurrence was 23% (1 benign, 3 borderline, and 2 malignant) after a mean follow-up of 13.6 months; all the recurrent tumors were initially treated by lumpectomy and were close to margin at the initial pathologic examination; the treatment of recurrences consisted of simple mastectomy in 5 cases, and local excision in one case; three patients developed metastases, one of whom after recurrence<b>;</b> three patients have died.
  • Conclusions: This is a substantial single institution experience of a rare tumor.
  • Phyllodes tumors of the breast have an unpredictable outcome, thus a wide local excision, with an adequate margin of normal breast tissue, is the preferred initial therapy.

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  • (PMID = 29147192.001).
  • [ISSN] 1920-454X
  • [Journal-full-title] World journal of oncology
  • [ISO-abbreviation] World J Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Keywords] NOTNLM ; Outcome / Pathology / Phyllodes tumor / Prognosis / Treatment
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34. Andersson S, Mints M, Sällström J, Wilander E: The relative distribution of oncogenic types of human papillomavirus in benign, pre-malignant and malignant cervical biopsies. A study with human papillomavirus deoxyribonucleic acid sequence analysis. Cancer Detect Prev; 2005;29(1):37-41
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  • [Title] The relative distribution of oncogenic types of human papillomavirus in benign, pre-malignant and malignant cervical biopsies. A study with human papillomavirus deoxyribonucleic acid sequence analysis.
  • The aim of the present investigation was to define the spectrum of oncogenic types of human papillomavirus (HPV) present in benign, pre-malignant (low-grade and high-grade squamous intraepithelial lesions, LSIL and HSIL) and malignant cervical lesions.
  • In 170 benign or pre-maligant alterations, the most common being HPV 16 (51%), HPV 31 (8%), HPV 18 (7%) and HPV 45 (6%).
  • The most common oncogenic HPV types (16 and 18), occurring in 45 invasive squamous carcinomas, comprised 76 per cent of the tumours, whereas less frequent HPV types (31, 33, 52, 56, 67, 70 and 73) were each found in about 2-4%.
  • [MeSH-major] Cervical Intraepithelial Neoplasia / pathology. Cervical Intraepithelial Neoplasia / virology. DNA, Viral / analysis. Oncogenes / genetics. Papillomaviridae / genetics. Papillomaviridae / pathogenicity. Papillomavirus Infections / complications. Precancerous Conditions / pathology. Precancerous Conditions / virology. Uterine Cervical Diseases / pathology. Uterine Cervical Diseases / virology. Uterine Cervical Neoplasms / pathology. Uterine Cervical Neoplasms / virology


35. Ohta M, Seto M, Ijichi H, Miyabayashi K, Kudo Y, Mohri D, Asaoka Y, Tada M, Tanaka Y, Ikenoue T, Kanai F, Kawabe T, Omata M: Decreased expression of the RAS-GTPase activating protein RASAL1 is associated with colorectal tumor progression. Gastroenterology; 2009 Jan;136(1):206-16
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  • [Title] Decreased expression of the RAS-GTPase activating protein RASAL1 is associated with colorectal tumor progression.
  • The expression of the RAS protein activator like-1 (RASAL1) was examined in clinical colorectal neoplasms using immunohistochemistry.
  • The clinicopathologic (age, sex, and tumor site and grade) and molecular (KRAS gene mutation, as well as CTNNB1 and TP53 expression patterns) factors that could affect RASAL1 expression were examined.
  • RASAL1 expression levels were correlated with the presence of wild-type KRAS gene in CRC tumor samples (P= .0010), distal location (P= .0066), and abnormal expression of TP53 (P= .0208).
  • Reductions in RASAL1 expression were detected more frequently in advanced lesions than in small adenomas, suggesting that RASAL1 functions in the progression of benign colonic neoplasms.
  • [MeSH-major] Colorectal Neoplasms / etiology. Tumor Suppressor Proteins / physiology. ras GTPase-Activating Proteins / physiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Line, Tumor. DNA Methylation. Disease Progression. Female. Gene Silencing. Genes, ras. Humans. Male. Middle Aged. Signal Transduction


36. Osadchy A, Zehavi T, Zissin R: Pulmonary benign metastasising leiomyomas presenting as fluid-containing masses on CT in a patient with two unrelated malignancies. Br J Radiol; 2005 Jul;78(931):639-41
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  • [Title] Pulmonary benign metastasising leiomyomas presenting as fluid-containing masses on CT in a patient with two unrelated malignancies.
  • [MeSH-major] Leiomyoma / radiography. Lung Neoplasms / secondary. Neoplasms, Multiple Primary / radiography
  • [MeSH-minor] Adenocarcinoma, Papillary / radiography. Carcinoma, Renal Cell / radiography. Female. Humans. Kidney Neoplasms / radiography. Middle Aged. Thyroid Neoplasms / radiography. Tomography, X-Ray Computed

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  • (PMID = 15961848.001).
  • [ISSN] 0007-1285
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 8
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37. Dalit A, Karen M, Alexander M: Congenital desmoid tumor of the cheek: a clinicopathological case report. Eplasty; 2009;9:e52
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  • [Title] Congenital desmoid tumor of the cheek: a clinicopathological case report.
  • OBJECTIVE: Desmoid tumors are rare benign neoplasms of fibroblastic origin, frequently presenting in the abdomen of adult patients.
  • Little is reported about clinical features and outcome of desmoid tumors appearing in infants and children, especially when they are located in the face.
  • METHODS: We report a girl with a desmoid tumor of her cheek, which was present at birth.
  • RESULTS: The tumor was treated by surgical excision, with no additional treatment, other than follow-up.
  • No recurrence of the tumor was witnessed 15 months following surgical excision.
  • SUMMARY: Radical surgical treatment with tumor excision, sometimes accompanied by radiotherapy, is the current standard therapy for infantile desmoid tumors.
  • These modalities may be challenging when desmoid tumors appear in the face because of risks of facial distortion and associated growth problems.

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  • (PMID = 20011031.001).
  • [ISSN] 1937-5719
  • [Journal-full-title] Eplasty
  • [ISO-abbreviation] Eplasty
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2779781
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38. Jinhu Y, Jianping D, Jun M, Hui S, Yepeng F: Metastasis of a histologically benign choroid plexus papilloma: case report and review of the literature. J Neurooncol; 2007 May;83(1):47-52
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  • [Title] Metastasis of a histologically benign choroid plexus papilloma: case report and review of the literature.
  • Cerebrospinal metastases of benign choroid plexus papillomas (CPPs) are extremely rare.
  • Plain CT scan of the cranium revealed a partly calcified tumor filling the fourth ventricle and its right recess.
  • Cranial MRI showed an inhomogeneously contrast-enhancing tumor and leptomeningeal enhancement encasing the brain stem.
  • Complete resection of the tumor was carried out, and seedings to the floor of the fourth ventricle and cervico-medullary junction were found during the operation.
  • While intraoperative frozen section suggested pathology of papillary ependymoma or CPP, to our surprise, final histological examination revealed a benign choroid plexus papilloma.
  • Two months after the first operation, on follow-up MRI of the cranium, the leptomeningeal enhancement encasing the brain stem had resolved spontaneously.
  • This special case helps increase our understanding of benign CPPs and expands our differential diagnostic consideration of lesions with similar manifestations.
  • [MeSH-major] Central Nervous System Neoplasms / secondary. Cerebral Ventricle Neoplasms / secondary. Choroid Plexus Neoplasms / pathology. Choroid Plexus Neoplasms / secondary. Fourth Ventricle. Papilloma / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Neoplasm Seeding. Neurosurgical Procedures / adverse effects. Subarachnoid Space. Tomography, X-Ray Computed

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  • (PMID = 17387433.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 33
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39. Yamaguchi Y, Kinouchii T, Yasuhara Y, Kakimoto K, Ono Y, Meguro N, Maeda O, Usami M: [Renal lymphangioma: report of a case]. Hinyokika Kiyo; 2007 Feb;53(2):113-5
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  • [Title] [Renal lymphangioma: report of a case].
  • Renal lymphangioma is a very rare benign tumor caused by failure in the development of the lymphatic communication system.
  • Computed tomography demonstrated a right renal multilocular cystic tumor, 5.5 cm in diameter, which was enhanced by contrast medium.
  • Radical nephrectomy was performed, and the pathological diagnosis was renal lymphangioma based on positive staining with D2-40 antibody, which is reactive to endothelial cells of the lymphatics.
  • [MeSH-major] Kidney Neoplasms / pathology. Kidney Neoplasms / surgery. Lymphangioma / pathology. Lymphangioma / surgery

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  • (PMID = 17352161.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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40. Levy BF, Nisar A, Karanjia ND: Cholangiocarcinoma, renal cell carcinoma and parathyroid adenoma found synchronously in a patient on long-term methotrexate. HPB (Oxford); 2006;8(2):151-3
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  • [Title] Cholangiocarcinoma, renal cell carcinoma and parathyroid adenoma found synchronously in a patient on long-term methotrexate.
  • Cases of patients developing lymphoma and cutaneous neoplasms after long-term methotrexate therapy are well documented in the literature; however, there are no reported cases of other neoplasms resulting from methotrexate therapy.
  • Investigation with ultrasound, CT scanning and MRCP showed a hilar cholangiocarcinoma and a synchronous right renal tumour.
  • A left hemi-hepatectomy extended to segments 5 and 8 with the formation of a hepaticojejunostomy was performed for a poorly differentiated infiltrative hilar cholangiocarcinoma.
  • It seems likely that treatment with methotrexate was causal in the development of these three non-cutaneous neoplasms-two malignant and one benign.

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  • (PMID = 18333265.001).
  • [ISSN] 1365-182X
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2131422
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46. Gonçalves AJ, Carvalho LH, Serdeira K, Nakai MY, Malavasi TR: Comparative analysis of the prevalence of the glutathione S-transferase (GST) system in malignant and benign thyroid tumor cells. Sao Paulo Med J; 2007 Sep 6;125(5):289-91
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  • [Title] Comparative analysis of the prevalence of the glutathione S-transferase (GST) system in malignant and benign thyroid tumor cells.
  • CONTEXT AND OBJECTIVE: When null, the mu and theta genes of the glutathione S-transferase system (GSTM1 and GSTT1, respectively) are related to malignant tumors affecting the lungs, colon, prostate, bladder and head and neck.
  • The aim of this study was to compare the frequencies of these genes in patients with benign and malignant tumors of the thyroid gland.
  • DESIGN AND SETTINGS: This was a cross-sectional clinical trial carried out in the Head and Neck Surgery Division, Faculdade de Medicina da Santa Casa de São Paulo.
  • METHODS: Samples of thyroid tissue were collected from 32 patients and divided into two groups: benign tumor (A) and malignant tumor (B).
  • RESULTS: The B group presented four cases of positive genotyping for both genes, seven positive for GSTT1 and negative for GSTM1, two negative for GSTT1 and positive for GSTM1, and only one case of double negative.
  • The A group showed 11 cases with positive genotyping for both genes and none with the double negative genotype.
  • CONCLUSION: In this study, there was no relationship between the presence of the GSTT1 and GSTM1 genes and the benign and malignant thyroid tumors.
  • [MeSH-major] Adenocarcinoma, Follicular / genetics. Carcinoma, Papillary / genetics. Glutathione Transferase / genetics. Thyroid Neoplasms / genetics
  • [MeSH-minor] Biomarkers, Tumor / genetics. Cross-Sectional Studies. Female. Genotype. Humans. Male

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  • (PMID = 18094897.001).
  • [ISSN] 1516-3180
  • [Journal-full-title] São Paulo medical journal = Revista paulista de medicina
  • [ISO-abbreviation] Sao Paulo Med J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.5.1.- / glutathione S-transferase T1; EC 2.5.1.18 / Glutathione Transferase; EC 2.5.1.18 / glutathione S-transferase M1
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47. Vijayalakshmi P, Jethani J, Kim U: Congenital unilateral ocular fibrosis syndrome secondary to benign congenital tumor. Indian J Ophthalmol; 2006 Jun;54(2):123-5
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  • [Title] Congenital unilateral ocular fibrosis syndrome secondary to benign congenital tumor.
  • We report a case of this rare syndrome associated with an adjacent sinus tumor.
  • [MeSH-major] Oculomotor Muscles / pathology. Orbital Neoplasms / complications
  • [MeSH-minor] Diagnosis, Differential. Female. Fibrosis / congenital. Fibrosis / etiology. Fibrosis / pathology. Humans. Infant. Magnetic Resonance Imaging

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  • (PMID = 16770032.001).
  • [ISSN] 0301-4738
  • [Journal-full-title] Indian journal of ophthalmology
  • [ISO-abbreviation] Indian J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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48. Ławicki S, Szmitkowski M, Wojtukiewicz M: The pretreatment plasma level and diagnostic utility of M-CSF in benign breast tumor and breast cancer patients. Clin Chim Acta; 2006 Sep;371(1-2):112-6
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  • [Title] The pretreatment plasma level and diagnostic utility of M-CSF in benign breast tumor and breast cancer patients.
  • BACKGROUND: In the present study, we investigated the plasma levels of M-CSF and commonly accepted tumor marker (antigen CA 15-3) in breast cancer patients in relation to the group with benign breast tumor and to the healthy controls.
  • Additionally, we compared the plasma level of M-CSF with the tumor stage of breast cancer and defined the diagnostic criteria: sensitivity, specificity, the positive and the negative predictive values.
  • METHODS: M-CSF and CA 15-3 were measured in 80 patients with breast cancer, 17 patients with benign breast tumor and in 30 healthy subjects.
  • RESULTS: There were statistically significant differences in the levels of circulating M-CSF and CA 15-3 in the breast cancer patients comparing to the group with benign breast tumor and to the control group.
  • The levels of M-CSF and CA 15-3 were also significantly higher in patients with more advanced tumor stage.
  • Statistically significant positive correlation was observed between the M-CSF and CA 15-3 levels.
  • The M-CSF and CA 15-3 diagnostic specificities were 95%.
  • We observed a higher range of the diagnostic sensitivity of M-CSF in more advanced breast tumor stage.
  • The M-CSF area under the ROC curve was larger (0.801) than the ROC area of CA 15-3 (0.785).
  • CONCLUSIONS: These results suggest that M-CSF is the good candidate for a breast cancer tumor marker.
  • [MeSH-major] Biomarkers, Tumor / blood. Breast Neoplasms / blood. Breast Neoplasms / diagnosis. Macrophage Colony-Stimulating Factor / blood. Mucin-1 / blood
  • [MeSH-minor] Adult. Aged. Enzyme-Linked Immunosorbent Assay. Female. Humans. Middle Aged. Neoplasm Staging. ROC Curve. Reagent Kits, Diagnostic. Sensitivity and Specificity

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  • (PMID = 16631152.001).
  • [ISSN] 0009-8981
  • [Journal-full-title] Clinica chimica acta; international journal of clinical chemistry
  • [ISO-abbreviation] Clin. Chim. Acta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucin-1; 0 / Reagent Kits, Diagnostic; 81627-83-0 / Macrophage Colony-Stimulating Factor
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49. Dhouib RS, Sassi S, Jbeli A, Driss M, Mrad K, Abbes I, Ben Romdhane K: Desmoplastic spitz nevus: report of a case and review of the literature. Pathologica; 2008 Jun;100(3):181-4
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  • [Title] Desmoplastic spitz nevus: report of a case and review of the literature.
  • The histologic features of this benign tumour may mimic those of certain benign (dermatofibroma and desmoplastic cellular blue nevus) or malignant (metastatic carcinoma and malignant melanoma) neoplasms.
  • We report the case of a male with a DSN, and also review the clinical characteristics, histologic features and differential diagnosis of this extremely rare lesion.
  • The neoplastic cells were large and epithelioid-shaped, and were either isolated as individual cells or arranged in small nests in a paucicellular hyalinized stroma.
  • Diffuse expression of S100 and the absence of staining with antibodies to melan-A and HMB45 was observed.
  • A diagnosis of DSN with free margins was made.
  • The histologic presentation of this benign lesion mimics both benign and malignant neoplasms.
  • The immunohistochemical profile (S100 positive, HMB-45 negative and cytokeratin negative) may be helpful to differentiate it from other lesions.
  • [MeSH-major] Nevus, Epithelioid and Spindle Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 18841824.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 15
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50. Zhen B, Shen Y, Zhang YM, Zhu CH, Liu ZL: [Analysis of the differences in the expression of HSP27 and c-kit between benign prostatic hyperplasia and prostatic cancer tissues]. Zhonghua Nan Ke Xue; 2006 May;12(5):416-20
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  • [Title] [Analysis of the differences in the expression of HSP27 and c-kit between benign prostatic hyperplasia and prostatic cancer tissues].
  • OBJECTIVE: To examine the differences in the expression of HSP27 and c-kit between benign prostatic hyperplasia (BPH) and prostatic cancer (PCa) tissues and to analyse the relationship between their expression and BPH and PCa, especially the relationship with the occurrence, development, prognosis and treatment of PCa.
  • METHODS: An immunohistochemical staining (SP method) for HSP27 and c-kit was undertaken on 40 BPH and 40 PCa tissues samples.
  • The expression of c-kit in PCa tissues was lower than BPH (P < 0.05).
  • The expression level of both HSP27 and c-kit were decreased with the development of grade of PCa (P < 0.05); HSP27 was increased with the development of clinical stage of PCa (P < 0.05 ); c-kit was decreased with the development of clinical stage of PCa (P < 0.05).
  • CONCLUSION: The expression level of HSP27 and c-kit was highly correlated with the process of the development from BPH to PCa, and also correlated with tumor grades and stages.
  • The expression of HSP27 and c-kit may be used as an important pathological index and may be helpful for the treatment of PCa.
  • [MeSH-major] Heat-Shock Proteins / biosynthesis. Neoplasm Proteins / biosynthesis. Prostatic Hyperplasia / metabolism. Prostatic Neoplasms / metabolism. Proto-Oncogene Proteins c-kit / biosynthesis


51. Mazzoleni S, Stomaci D, Rizzo A, Rigo L, Bressan E, Stellini E: Solitary neurofibroma of the palate. A case report. Minerva Stomatol; 2009 Sep;58(9):453-8
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  • The neurofibroma is a benign tumor of neuronal origin not frequently located in the oral cavity.
  • The possible association of this neoplasia with systemic pathologies, such as Von Recklinghausen's disease and multiple endocrine neoplasia, makes its diagnosis fundamental.
  • The diagnosis is, in most cases, quite complex, because of the neurofibroma's strong similarities with a great number of benign neoformations of the connective tissue, of the epithelium, and of the bone.
  • This articles presents the case of a solitary neurofibroma, subtype I (common Schwann cell type), detected on the left-hand side of the posterior region of the palate in a 56-year-old woman, which presented itself as an otherwise non-symptomatic ulcerated mass.
  • The immunohistochemical test, which resulted positive for S-100 and negative for the epithelial membrane antigen and keratin, allowed the diagnosis of a presumably benign lesion deriving from a neural differentiation.
  • [MeSH-major] Neurofibroma / pathology. Palatal Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Middle Aged. Molar. Neurofibromatoses / diagnosis. Oral Ulcer / etiology. Tooth Extraction

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  • (PMID = 19893470.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng; ita
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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52. Laroia AT, Thompson BH, Laroia ST, van Beek E Jr: Modern imaging of the tracheo-bronchial tree. World J Radiol; 2010 Jul 28;2(7):237-48
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  • This article is a comprehensive review of trachea and main bronchi imaging, with emphasis on the dynamic airway anatomy, and a discussion of a wide variety of diseases including, but not limited to, congenital large airway abnormalities, tracheobronchial stenoses, benign and malignant neoplasms and tracheobronchomalacia.
  • The importance of multiplanar reconstruction, 3-D reconstruction and incorporation of dynamic imaging for non-invasive evaluation of the large airways is stressed.

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  • (PMID = 21160663.001).
  • [ISSN] 1949-8470
  • [Journal-full-title] World journal of radiology
  • [ISO-abbreviation] World J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2998855
  • [Keywords] NOTNLM ; Advanced imaging / Airways / Bronchial tree / Computed tomography / Trachea
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53. Müller MW, Assfalg V, Michalski CW, Büchler P, Kleeff J, Friess H: [Middle segmental pancreatic resection: an organ-preserving option for benign lesions]. Chirurg; 2009 Jan;80(1):14-21
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  • [Title] [Middle segmental pancreatic resection: an organ-preserving option for benign lesions].
  • Benign and low malignant tumors of the middle pancreatic segment can be resected by extended pancreaticoduodenectomy or distal pancreatic resection.
  • Normal pancreatic tissue can be preserved as only the tumor with a pancreatic segment is resected.
  • The indication should be limited exclusively to benign or low malignant pancreatic tumors, metastases from other tumors, and focal chronic pancreatitis, as this type of resection cannot be deemed oncologic.
  • [MeSH-major] Minimally Invasive Surgical Procedures / methods. Pancreatectomy / methods. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods. Pancreatitis / surgery. Precancerous Conditions / surgery

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  • (PMID = 19011818.001).
  • [ISSN] 1433-0385
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 42
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54. Reddy S, Wolfgang CL: Benign pancreatic tumors. Surg Clin North Am; 2007 Dec;87(6):1359-78, viii
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  • [Title] Benign pancreatic tumors.
  • The goal of this article is to describe the different types of benign pancreatic neoplasms, methods to distinguish between them, and treatment options.
  • Pancreatic adenocarcinoma is associated with specific neoplastic lesions that are similar in radiographic appearance to some benign lesions.
  • The correct differentiation of these malignant and premalignant lesions from their benign counterpart is paramount to their proper management.
  • [MeSH-major] Pancreatic Neoplasms
  • [MeSH-minor] Algorithms. Carcinoma, Neuroendocrine / pathology. Cystadenoma, Mucinous / diagnosis. Cystadenoma, Serous / diagnosis. Humans. Neuroectodermal Tumors, Primitive / diagnosis. Neuroectodermal Tumors, Primitive / surgery. Pancreatic Pseudocyst / diagnosis. Pancreatitis, Chronic / pathology. Sclerosis. Tomography, X-Ray Computed. Vipoma / diagnosis

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  • (PMID = 18053836.001).
  • [ISSN] 0039-6109
  • [Journal-full-title] The Surgical clinics of North America
  • [ISO-abbreviation] Surg. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 63
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55. Crippa S, Boninsegna L, Partelli S, Falconi M: Parenchyma-sparing resections for pancreatic neoplasms. J Hepatobiliary Pancreat Sci; 2010 Nov;17(6):782-7
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  • [Title] Parenchyma-sparing resections for pancreatic neoplasms.
  • BACKGROUND/PURPOSE: In recent years there has been an increase in the indications for pancreatic resection of benign or low-grade malignant lesions, especially in young patients with long life expectancy.
  • CONCLUSIONS: Parenchyma-sparing resections are safe and effective procedures for treatment of benign and low-grade malignant neoplasms.
  • [MeSH-major] Pancreatectomy / methods. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Humans. Laparoscopy. Neoplasm Recurrence, Local. Treatment Outcome

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  • [CommentIn] J Hepatobiliary Pancreat Sci. 2010 Mar;17(2):203 [20454911.001]
  • (PMID = 19865792.001).
  • [ISSN] 1868-6982
  • [Journal-full-title] Journal of hepato-biliary-pancreatic sciences
  • [ISO-abbreviation] J Hepatobiliary Pancreat Sci
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
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56. Park BK, Kim CK: Re: the value of preoperative needle core biopsy for diagnosing benign lesions among small, incidentally detected renal masses: B. A. Shannon, R. J. Cohen, H. de Bruto and R. J. Davies J Urol 2008; 180: 1257-1261. J Urol; 2009 Apr;181(4):1959-60; author reply 1960
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  • [Title] Re: the value of preoperative needle core biopsy for diagnosing benign lesions among small, incidentally detected renal masses: B. A. Shannon, R. J. Cohen, H. de Bruto and R. J. Davies J Urol 2008; 180: 1257-1261.
  • [MeSH-major] Kidney Neoplasms / pathology

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  • [CommentOn] J Urol. 2008 Oct;180(4):1257-61; discussion 1261 [18707712.001]
  • (PMID = 19246051.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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57. Busam KJ, Kucukgöl D, Sato E, Frosina D, Teruya-Feldstein J, Jungbluth AA: Immunohistochemical analysis of novel monoclonal antibody PNL2 and comparison with other melanocyte differentiation markers. Am J Surg Pathol; 2005 Mar;29(3):400-6
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  • [Title] Immunohistochemical analysis of novel monoclonal antibody PNL2 and comparison with other melanocyte differentiation markers.
  • PNL2 is a novel monoclonal antibody, which has recently been introduced as an immunohistochemical reagent to stain melanocyte and tumors derived thereof.
  • In the present study, we analyzed the immunoreactivity of this mAb in various normal tissues, melanocytic nevi, primary and metastatic melanoma, nonmelanocytic tumors, including histologic mimickers of melanoma as well as angiomyolipoma, and multiple cell lines derived from different tumors types.
  • Positive staining with PNL2 was found in normal melanocytes and neutrophils, but no other normal cell type.
  • Among melanocytic lesions, both benign nevi as well as primary malignant melanomas, especially epithelioid variants thereof, were commonly immunopositive.
  • None of the selected nonmelanocytic tumors (carcinomas or soft tissue neoplasms) was positive for PNL2 in this series except for angiomyolipomas and chronic myeloid leukemias and 1 single case of a malignant peripheral nerve sheath tumor with heterologous differentiation (malignant Triton tumor).
  • Despite its reactivity with neutrophils, PNL2 appears to be a valuable supplementary reagent for the diagnosis of melanocytic tumors.
  • [MeSH-major] Antibodies, Monoclonal. Melanoma / chemistry. Nevus / chemistry. Skin Neoplasms / chemistry

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  • (PMID = 15725810.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Biomarkers
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58. Meenakshi M, McCluggage WG: Myoepithelial neoplasms involving the vulva and vagina: report of 4 cases. Hum Pathol; 2009 Dec;40(12):1747-53
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  • [Title] Myoepithelial neoplasms involving the vulva and vagina: report of 4 cases.
  • We report 4 myoepitheial neoplasms involving the vulva (2 cases) or vagina (2 cases) in patients aged 40 to 45.
  • Two tumors were composed entirely of ovoid or spindle-shaped cells, one entirely of epithelioid cells, and in the other, there was a mixture of spindled and epithelioid cells.
  • Small foci of ductal differentiation with squamous metaplasia were present in one case and a minor stromal component, which varied from myxoid to hyalinized, in all cases.
  • In all cases, the tumor cells were positive for epithelial markers (cytokeratins and/or epithelial membrane antigen) and the myoid markers alpha smooth muscle actin and calponin.
  • S100 and p63 were positive in 1 of the 4 neoplasms.
  • On the basis of the nuclear features and degree of mitotic activity, 2 neoplasms were classified as benign myoepitheliomas and 2 as myoepithelial carcinomas.
  • Judging by the paucity of cases in the literature, myoepithelial neoplasms appear extremely rare in the vulvovaginal region with only 3 previous case reports of primary vulval tumors.
  • As far as we are aware, this is the first description of a primary vaginal myoepithelial neoplasm.
  • At these sites, myoepithelial tumors are liable to be misdiagnosed as a variety of other neoplasms because the pathologist may not think of the diagnosis.
  • In reporting these cases, we discuss the criteria for diagnosis and the differential diagnosis.
  • [MeSH-major] Carcinoma / pathology. Myoepithelioma / pathology. Vaginal Neoplasms / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged

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  • (PMID = 19716162.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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59. Karim Z, Walker B, Lam E: Lymphoepithelial cysts of the pancreas: the use of endoscopic ultrasound-guided fine-needle aspiration in diagnosis. Can J Gastroenterol; 2010 Jun;24(6):348-50
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  • [Title] Lymphoepithelial cysts of the pancreas: the use of endoscopic ultrasound-guided fine-needle aspiration in diagnosis.
  • Lymphoepithelial cysts (LECs) are rare non-neoplastic lesions that can appear as a complex cyst or a mass in the pancreas.
  • Cytology from endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) can be helpful in making a diagnosis with the aim of avoiding unnecessary surgical resection.
  • Cytology from EUS-FNA can help distinguish LECs from cystic neoplasms, thus preventing radical surgical resection of this benign pancreatic cyst.

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  • (PMID = 20559575.001).
  • [ISSN] 0835-7900
  • [Journal-full-title] Canadian journal of gastroenterology = Journal canadien de gastroenterologie
  • [ISO-abbreviation] Can. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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  • [Other-IDs] NLM/ PMC2898487
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60. Thompson RH, Kurta JM, Kaag M, Tickoo SK, Kundu S, Katz D, Nogueira L, Reuter VE, Russo P: Tumor size is associated with malignant potential in renal cell carcinoma cases. J Urol; 2009 May;181(5):2033-6
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  • [Title] Tumor size is associated with malignant potential in renal cell carcinoma cases.
  • PURPOSE: We evaluated our experience with renal cortical tumors to determine whether tumor size is associated with malignant histology and/or nuclear grade.
  • MATERIALS AND METHODS: We identified 2,675 patients treated surgically at our institution for renal cell carcinoma or a benign tumor between 1989 and 2007.
  • Histological subtype and tumor size were obtained from our kidney cancer database and logistic regression analysis was performed.
  • RESULTS: Of the 2,675 tumors 311 (12%) were benign and 2,364 (88%) were renal cell carcinoma.
  • The OR for the association of malignancy with tumor size was 1.16 (95% CI 1.11-1.22, p <0.001), indicating that each 1 cm increase in tumor size was associated with a 16% increase in the odds of malignancy.
  • The incidence of benign tumors decreased from 38% for tumors less than 1 cm to 7% for tumors 7 cm or greater.
  • In patients with clear cell renal cell carcinoma each 1 cm increase in tumor size increased the odds of high grade disease (Fuhrman grade 3-4) compared with low grade disease (Fuhrman grade 1-2) by 25% (OR 1.25, 95% CI 1.21-1.30, p <0.001).
  • In this subset the incidence of high grade lesions increased from 0% for tumors less than 1 cm to 59% for tumors greater than 7 cm.
  • CONCLUSIONS: Our results confirm previous observations suggesting that the risks of malignancy and high grade tumors increase with tumor size.

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  • [Cites] J Urol. 2000 Mar;163(3):730-6 [10687966.001]
  • [Cites] J Urol. 2003 Jul;170(1):64-8 [12796646.001]
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  • (PMID = 19286217.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / T32 CA082088; None / None / / T32 CA082088-09; United States / NCI NIH HHS / CA / T32 CA082088-09; United States / NCI NIH HHS / CA / T32-CA82088
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS131623; NLM/ PMC2734327
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61. Chiang JM, Lin YS: Tumor spectrum of adult intussusception. J Surg Oncol; 2008 Nov 1;98(6):444-7
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  • [Title] Tumor spectrum of adult intussusception.
  • Data related to presentation, diagnosis, treatment, and pathology were analyzed.
  • Neoplasm was identified as the cause of intussusception in 66 (92%) cases, and 6 (8%) were idiopathic.
  • Lipoma (15 of 40 patients, 38%) and Peutz-Jegher adenoma (10 of 40 patients, 25%) were the two most common lesions of benign small bowel neoplasms while 27% (3 of 11) of malignant enteric intussusception cases were malignant lymphoma and metastatic respectively.
  • CONCLUSION: Lipoma is the most common benign tumor in both small and large bowel intussusception.
  • Whereas 80% of tumors associated with small bowel intussusception were benign, two-thirds of colonic intussusceptions had resulted from primary adenocarcinoma.
  • [MeSH-major] Intestinal Diseases / etiology. Intestinal Neoplasms / complications. Intussusception / etiology

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • [ErratumIn] J Surg Oncol. 2009 Jun 1;99(7):457
  • (PMID = 18668640.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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62. Stang A, Keles H, Hentschke S, von Seydewitz CU, Dahlke J, Malzfeldt E, Braumann D: Differentiation of benign from malignant focal splenic lesions using sulfur hexafluoride-filled microbubble contrast-enhanced pulse-inversion sonography. AJR Am J Roentgenol; 2009 Sep;193(3):709-21
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  • [Title] Differentiation of benign from malignant focal splenic lesions using sulfur hexafluoride-filled microbubble contrast-enhanced pulse-inversion sonography.
  • MATERIALS AND METHODS: One hundred forty-seven splenic lesions (68 benign, 79 malignant) in 147 patients (81 men, 66 women; mean age, 51 years) underwent baseline gray-scale sonography and sulfur hexafluoride-enhanced low-acoustic-power pulse-inversion sonography (mechanical index < 0.1).
  • Two site investigators assessed in consensus lesion and splenic enhancement during arterial and parenchymal phases.
  • Four readers (readers 1 and 2, blinded; and readers 3 and 4, unblinded to clinical data) independently reviewed baseline and contrast-enhanced sonograms and provided confidence rating for diagnosis of malignancy or benignancy.
  • RESULTS: Benign lesions appeared predominately non- or isoenhancing relative to splenic parenchyma, whereas malignant lesions appeared predominately progressively hypoenhancing.
  • For correct diagnosis of benignancy or malignancy, review of contrast-enhanced sonography after baseline sonography yielded significantly improved diagnostic performance (overall accuracy, 51%, 43%, 70%, and 74% before vs 83%, 81%, 92%, and 91% after contrast-enhanced sonography for readers 1, 2, 3, and 4; p < 0.05; respectively) and significantly improved diagnostic confidence (A(z), 0.770, 0.678, 0.900, and 0.917 before vs 0.935, 0.917, 0.984, and 0.959 after contrast-enhanced sonography for readers 1, 2, 3, and 4; p < 0.05; respectively).
  • [MeSH-major] Phospholipids. Splenic Neoplasms / ultrasonography. Sulfur Hexafluoride
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Contrast Media. Diagnosis, Differential. Female. Humans. Male. Microbubbles. Middle Aged. Predictive Value of Tests. ROC Curve. Retrospective Studies. Sensitivity and Specificity. Splenectomy

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  • (PMID = 19696284.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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63. Schittenhelm J, Ebner FH, Harter P, Bornemann A: Symptomatic intraspinal oncocytic adrenocortical adenoma. Endocr Pathol; 2009;20(1):73-7
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  • Most intraspinal neoplasms of epithelial origin are metastases from primary carcinomas.
  • Benign epithelial tumors are rarely found at this site.
  • We here present the case of a 44-year-old woman with a lesion in the cauda equina that fulfilled the radiologic criteria of schwannoma and caused clinical symptoms for 3 years.
  • The excised tumor was composed of nests of large polygonal cells with eosinophilic partial granular cytoplasm.
  • The tumor showed diffuse positivity for melan-A, synaptophysin, and alpha-inhibin.
  • Steroidogenic factor 1 and cytokeratins 8 and 18 were focally seen in the absence of S-100 and chromogranin.
  • Ultrastructural examination showed abundant mitochondria, suggesting an oncocytic tumor.
  • The diagnosis of an oncocytic adrenal cortical adenoma was made.
  • These extraadrenal tumors are thought to arise from heterotopic adrenocortical tissue in the spinal cavity.
  • Oncocytic tumors are rare neoplasms and they comprise non-functioning variants of adrenal cortical adenomas.
  • To date, only five such intraspinal tumors have been observed.
  • Immunohistochemistry excluded oncocytic paraganglioma, oncocytic meningioma, renal cell carcinoma, alveolar soft part sarcoma, and granular cell tumor.
  • A view of the literature of these rare but probably underdiagnosed intraspinal tumors is given.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Adrenocortical Adenoma / pathology. Spinal Cord Neoplasms / pathology

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  • (PMID = 19039533.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Saussez S, Glinoer D, Chantrain G, Pattou F, Carnaille B, André S, Gabius HJ, Laurent G: Serum galectin-1 and galectin-3 levels in benign and malignant nodular thyroid disease. Thyroid; 2008 Jul;18(7):705-12
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  • [Title] Serum galectin-1 and galectin-3 levels in benign and malignant nodular thyroid disease.
  • The goal of this study was to determine if a difference in galectin serum levels could be detected between benign and malignant nodular thyroid diseases.
  • DESIGN: Using validated ELISAs, the concentrations of several galectins were prospectively measured in serum samples from 30 healthy individuals and preoperatively in 90 patients with thyroid disease.
  • Seventy-one patients had multiple thyroid nodules (MTN), 13 patients had a single thyroid nodule (STN), and 6 patients had Graves' disease.
  • Nine of 71 patients with MTN had fine-needle aspiration biopsy (FNAB) of their nodules and in 7 patients a "benign" diagnosis was made, in 0 patient a "malignant" diagnosis was made, and in 2 patients a "suspicious" diagnosis was made.
  • Six of 13 patients with STN had FNAB of their nodules and in 2 patients a "benign" diagnosis was made, in 3 patients a "malignant" diagnosis was made, and in 1 patient a "suspicious" diagnosis was made.
  • RESULTS: Thyroid disease was associated with higher levels of galectins-1 and -3 compared to normal subjects.
  • Using a threshold value of 3.2 ng/mL as a cut-off point, the measurement of serum galectin-3 separated micro- and macropapillary thyroid carcinoma (PAP_CA) from patients with nonmalignant thyroid disease with 74% specificity, 73% sensitivity, 57% positive predictive value, and 85% negative predictive value.
  • CONCLUSIONS: Serum levels of galectins-1 and -3 are relatively high in patients with thyroid malignancy but there is considerable overlap in serum galectin-3 concentrations between those with benign and malignant nodular thyroid disease and, to a lesser extent, between those with and without nodular thyroid disease.
  • [MeSH-major] Biomarkers, Tumor / blood. Galectin 1 / blood. Galectin 3 / blood. Thyroid Neoplasms / blood. Thyroid Nodule / blood
  • [MeSH-minor] Adult. Aged. Biopsy, Fine-Needle. Case-Control Studies. Female. Galectins / blood. Graves Disease / blood. Graves Disease / diagnosis. Graves Disease / pathology. Humans. Male. Middle Aged. Predictive Value of Tests. Prospective Studies. Sensitivity and Specificity

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  • (PMID = 18630998.001).
  • [ISSN] 1050-7256
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 1; 0 / Galectin 3; 0 / Galectins; 0 / LGALS7 protein, human
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65. Sahin D, Koç N, Etker S, Güven S, Canpolat C: Congenital pulmonary fibrosarcoma in a newborn with hypoglycemia and respiratory distress: case report. Turk J Pediatr; 2010 May-Jun;52(3):325-9
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  • [Title] Congenital pulmonary fibrosarcoma in a newborn with hypoglycemia and respiratory distress: case report.
  • Although primary bronchopulmonary fibrosarcoma is a rare tumor, it may be characterized by the symptoms of acute respiratory distress occurring during the first moments of life in a newborn.
  • It is one of the leading congenital malignant neoplasms of the lung, but is considered a borderline tumor since its biological behavior is much more favorable than that of adult fibrosarcomas.
  • Histopathological diagnosis is not simple, as the microscopic characteristics may be confused with benign fibromatosis or malignant mesenchymal neoplasms.
  • In this case report, we present a case of congenital pulmonary spindle cell tumor showing the features of fibrosarcoma, and we discuss the differential diagnosis of spindle cell lesions localized within the thorax.
  • [MeSH-major] Fibrosarcoma / congenital. Hypoglycemia / etiology. Lung Neoplasms / congenital. Respiratory Insufficiency / etiology


66. Kluger N, Perrochia H, Guillot B: Pelvic mass in von Recklinghausen's neurofibromatosis: diagnostic issues: a case report. Cases J; 2009;2:191
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  • BACKGROUND: Leiomyomas are benign smooth muscle cell tumours.
  • They are the most common uterine neoplasms, although they may also occur elsewhere, such as in the gastrointestinal and urinary tracts.
  • CASE REPORT: We report here the unusual case of a 47-year-old woman with NF1 who presented menorrhagias and a hard, tender pelvic mass composed of uterine leiomyomas.
  • Positron emission tomography/computed tomography disclosed an area of increased 18-fluorodeoxyglucose (FDG) uptake in the upper right part of the mass that raised the suspicion of malignancy.
  • Abdominal hysterectomy was performed and microscopic examination confirmed the diagnosis of multiple benign smooth muscle tumours (uterine leiomyomatosis).

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  • (PMID = 19946501.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2783146
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67. Pieta B, Opala T, Wilczak M, Grodecka-Gazdecka S, Kramer L, Samulak D, Wieznowska-Maczyńska K: Past obstetric history and risk of malignant breast neoplasms. Eur J Gynaecol Oncol; 2008;29(4):374-7
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  • [Title] Past obstetric history and risk of malignant breast neoplasms.
  • They are also probably responsible for the development of benign neoplasms and play a role in the origin and development of breast carcinoma.
  • The purpose of the study was to analyze the obstetrical past of patients and the potential influence on the risk of developing malignant breast neoplasms.
  • The participants in the study were healthy women with no changes in mammary glands (control group) and women with diagnosed malignant or benign breast neoplasms (study group).
  • Hormonal disorders in childhood and puberty symptoms of early menarche play a crucial role in increasing the risk of malignant breast neoplasms.
  • In women who experienced one or more miscarriages the risk of malignant breast neoplasms is significantly increased.
  • On the basis of our study we calculated the odds ratio (OR) of malignant breast neoplasms among women who during lactation experienced problems needing medical intervention (OR = 2.25; 95% CI, 1.20-4.19) in comparison to women who experienced no problems).
  • [MeSH-major] Breast Neoplasms / epidemiology. Reproductive History

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  • (PMID = 18714573.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Estrogens
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68. Meningioma. Understanding this usually benign brain tumor. Mayo Clin Health Lett; 2010 Jul;28(7):4-5
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  • [Title] Meningioma. Understanding this usually benign brain tumor.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / therapy. Health Knowledge, Attitudes, Practice. Meningioma / diagnosis. Meningioma / therapy

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  • (PMID = 20799379.001).
  • [ISSN] 0741-6245
  • [Journal-full-title] Mayo Clinic health letter (English ed.)
  • [ISO-abbreviation] Mayo Clin Health Lett
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. Manhès C, Kayser C, Bertheau P, Kelder B, Kopchick JJ, Kelly PA, Touraine P, Goffin V: Local over-expression of prolactin in differentiating mouse mammary gland induces functional defects and benign lesions, but no carcinoma. J Endocrinol; 2006 Aug;190(2):271-85
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  • [Title] Local over-expression of prolactin in differentiating mouse mammary gland induces functional defects and benign lesions, but no carcinoma.
  • Experimental, clinical, and epidemiological data support the growth-promoting role of endocrine prolactin (PRL) in mammary tumors.
  • Although some older, multiparous females developed benign tumors (papillomas and metaplasias), none of the animals studied developed mammary carcinomas.
  • This phenotype was due neither to failure of milk production nor to modification of its protein content, but rather it was correlated to lipid enrichment of the milk, which, in combination with profoundly altered morphology of the gland, led to impaired milk extrusion through the nipple.
  • In summary, these data show that over-expression of autocrine hPRL in a differentiating mammary gland induces dramatic functional and morphological defects, but not carcinoma.
  • [MeSH-major] Autocrine Communication. Lactation. Mammary Glands, Animal / metabolism. Mammary Neoplasms, Animal / metabolism. Prolactin / metabolism

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  • (PMID = 16899561.001).
  • [ISSN] 0022-0795
  • [Journal-full-title] The Journal of endocrinology
  • [ISO-abbreviation] J. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Milk Proteins; 0 / whey acidic proteins; 9002-62-4 / Prolactin
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70. Hanna SJ, Green AL, Ansorge O, Anslow P, Richards PG: Immature teratoma arising from a benign cortical abnormality. Childs Nerv Syst; 2006 Feb;22(2):164-7
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  • [Title] Immature teratoma arising from a benign cortical abnormality.
  • CASE REPORT: The authors report the case of an immature teratoma of the left parieto-occipital region in a 13-year-old girl.
  • The patient had a computed tomographic (CT) scan of the brain aged 10 months old, following a minor head injury.
  • This demonstrated an abnormality in the same region, which had been reported as 'a cortical malformation'.
  • DIAGNOSIS: We propose that the lesion on the original imaging is a mature teratoma or other silent dystopic germ cell element that subsequently transformed into the immature teratoma.
  • [MeSH-major] Brain Neoplasms / pathology. Neoplasms, Second Primary / pathology. Teratoma / secondary
  • [MeSH-minor] Adolescent. Cell Transformation, Neoplastic / pathology. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 15682320.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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71. Ahlhelm F, Schulte-Altedorneburg G, Naumann N, Nabhan A, Reith W: [Imaging of extradural spinal lesions]. Radiologe; 2006 Dec;46(12):1035-43
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  • There is a wide variety of spinal extradural tumors.
  • In addition to real neoplasms, degenerative diseases, congenital abnormalities and inflammatory disorders can be causes of extradural masses.
  • Due to the bony boundary of the spinal canal, both benign as well as malignant masses can cause progressive neurological deficits including paraplegia.
  • Most of the spinal tumors are benign (hemangioma of the vertebral body, degenerative diseases).
  • In younger patients congenital abnormalities and primary tumors of the spine have to be considered, whereas in adults the list of differential diagnoses should include secondary malignancies such as metastases and lymphomas as well as metabolic disorders such as osteoporotic vertebral compression fracture and Paget's disease.
  • Cross-sectional imaging techniques such as magnetic resonance imaging (MRI) and computed tomography (CT) of the spine often help to make a specific diagnosis of extradural spinal lesions and represent important tools for tumor staging and preoperative evaluation.
  • [MeSH-major] Epidural Neoplasms / diagnosis. Magnetic Resonance Imaging. Spinal Diseases / diagnosis. Spinal Neoplasms / diagnosis. Tomography, Spiral Computed
  • [MeSH-minor] Diagnosis, Differential. Epidural Space / pathology. Humans. Neurologic Examination. Spinal Cord / pathology. Spinal Cord Compression / diagnosis. Spine / pathology

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  • (PMID = 17066265.001).
  • [ISSN] 0033-832X
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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72. Bologna-Molina R, González-González R, Mosqueda-Taylor A, Molina-Frechero N, Damián-Matsumura P, Dominguez-Malagón H: Expression of syndecan-1 in papillary carcinoma of the thyroid with extracapsular invasion. Arch Med Res; 2010 Jan;41(1):33-7
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  • Evidence suggests that loss of SDC-1 expression in several benign and malignant epithelial neoplasms is an unfavorable prognostic indicator, but its expression profile in thyroid gland neoplasms remains to be elucidated.
  • The aim of this study was to evaluate SDC-1 expression in papillary carcinomas of the thyroid (PCT) that were both larger and smaller (papillary microcarcinoma) than 10mm, with or without extracapsular extension (PCT-E and PCT-NE).
  • METHODS: The expression of SDC-1 was studied in 62 cases of PCT-E and PCT-NE using a tissue microarrays technique (TMA).
  • SDC-1 positivity was predominantly observed in the cytoplasm of neoplastic epithelial cells and in the stroma of PCT.
  • RESULTS: SDC-1 is expressed in both neoplastic epithelial cells and the stroma.
  • It is more frequently expressed in PCT-E than PCT-NE (p=0.002) and the stromal expression of SDC-1 is more intense in PCT-E that are >10 mm (p=0.026).
  • [MeSH-major] Carcinoma, Papillary / metabolism. Neoplasm Invasiveness. Syndecan-1 / metabolism. Thyroid Neoplasms / metabolism

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  • [Copyright] 2010 IMSS. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20430252.001).
  • [ISSN] 1873-5487
  • [Journal-full-title] Archives of medical research
  • [ISO-abbreviation] Arch. Med. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Syndecan-1
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73. Bougrine F, Bacha D, Chouchane O, Laabidi B, Yeades M, Bouziani A: [Intracerebral schwannoma: case report]. Neurochirurgie; 2007 Nov;53(5):387-90
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  • BACKGROUND AND PURPOSE: We report a well-documented case of intracerebral schwannoma, presenting as a cystic and solid parietal mass, arising in a 20-year-old woman.
  • The tumor was removed through a right parietal craniotomy.
  • The patient is alive without progressive local disease or metastasis.
  • The most popular hypothesis argues that these tumors arise from the proliferation of Schwann cells in the perivascular nerve plexii.
  • CONCLUSIONS: Intracerebral schwannoma is an extremely rare benign tumor.
  • The importance of recognizing this tumor is stressed, particularly in younger patients, given its benign nature, radiological resemblance to other tumors and favorable response to resection without toxic treatment.
  • [MeSH-major] Brain Neoplasms / pathology. Neurilemmoma / pathology
  • [MeSH-minor] Adult. Female. Humans. Immunohistochemistry. Intracranial Hypertension / etiology. Magnetic Resonance Imaging. Neoplasm Metastasis. Neurosurgical Procedures. Seizures / etiology

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  • (PMID = 17884108.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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74. Haab BB, Porter A, Yue T, Li L, Scheiman J, Anderson MA, Barnes D, Schmidt CM, Feng Z, Simeone DM: Glycosylation variants of mucins and CEACAMs as candidate biomarkers for the diagnosis of pancreatic cystic neoplasms. Ann Surg; 2010 May;251(5):937-45
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  • [Title] Glycosylation variants of mucins and CEACAMs as candidate biomarkers for the diagnosis of pancreatic cystic neoplasms.
  • Here we explored whether glycosylation variants on specific proteins in cyst fluid samples could serve as biomarkers to aid in this diagnosis.
  • METHODS: We used a novel antibody-lectin sandwich microarray method to measure the protein expression and glycosylation of mucin (MUC)1, MUC5AC, MUC16, carcinoembryonic antigen, and other proteins implicated in pancreatic neoplasia in cyst fluid samples.
  • Fifty-three cyst fluid samples were obtained from patients with mucinous cystic neoplasms (n=17), intraductal papillary mucinous neoplasms (n=15), serous cystadenomas (n=12), or pseudocysts (n=9), with confirmation of histologic diagnosis at surgical resection.
  • RESULTS: The detection of a glycan variant on MUC5AC using the lectin wheat-germ agglutinin discriminated mucin-producing cystic tumors (mucinous cystic neoplasms+intraductal papillary mucinous neoplasms) from benign cystic lesions (serous cystadenomas+pseudocysts) with a 78% sensitivity at 80% specificity, and when used in combination with cyst fluid CA 19-9 gave a sensitivity of 87% at 86% specificity.
  • CONCLUSIONS: These results demonstrate the value of glycan variants for biomarker discovery and suggest that these biomarkers could greatly enhance the accuracy of differentiating pancreatic cystic tumors.

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  • (PMID = 20395854.001).
  • [ISSN] 1528-1140
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R03 CA112629; United States / NCI NIH HHS / CA / R21 CA122890; United States / NCI NIH HHS / CA / U01 CA117452; United States / NCI NIH HHS / CA / U01 1CA117452; United States / NCI NIH HHS / CA / R33 CA122890; United States / NCI NIH HHS / CA / 1 R03 CA 112629-01A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucins
  • [Other-IDs] NLM/ NIHMS484419; NLM/ PMC3713623
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75. Kirilovas D, Schedvins K, Naessén T, Von Schoultz B, Carlström K: Conversion of circulating estrone sulfate to 17beta-estradiol by ovarian tumor tissue: a possible mechanism behind elevated circulating concentrations of 17beta-estradiol in postmenopausal women with ovarian tumors. Gynecol Endocrinol; 2007 Jan;23(1):25-8
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  • [Title] Conversion of circulating estrone sulfate to 17beta-estradiol by ovarian tumor tissue: a possible mechanism behind elevated circulating concentrations of 17beta-estradiol in postmenopausal women with ovarian tumors.
  • AIM: Elevated serum levels of 17beta-estradiol (E2) are frequently found in postmenopausal women with ovarian tumors not classified as estrogen-producing.
  • Our aim was to find out if conversion of circulating E1S to E2 by the tumor tissue could be a reason for elevated serum E2 levels in postmenopausal women with 'non-estrogen-producing' ovarian tumors.
  • METHOD: Serum E2 was measured in 12 postmenopausal women with 'non-estrogen-producing' ovarian tumors (nine benign, three malignant).
  • Total hydrolysis of and [3H]E2 formation from [3H]E1S by the tumor tissue homogenates was studied in vitro.
  • RESULTS: Serum E2 showed significant positive correlations with total hydrolysis of and [3H]E2 formation from [3H]E1S in the total material as well as in the benign tumor subgroup.
  • CONCLUSION: Conversion of circulating E1S to E2 by the tumor tissue could be one important reason for elevated S-E2 levels in postmenopausal women with 'non-estrogen-producing' ovarian tumors.
  • [MeSH-major] Estradiol / metabolism. Estrone / analogs & derivatives. Ovarian Neoplasms / metabolism. Postmenopause

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  • (PMID = 17484508.001).
  • [ISSN] 0951-3590
  • [Journal-full-title] Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • [ISO-abbreviation] Gynecol. Endocrinol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 2DI9HA706A / Estrone; 4TI98Z838E / Estradiol; QTL48N278K / estrone sulfate
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76. Wang S, Ma XY, Xia Y, Zhang LH: [Expressions of Ki67, PCNA and mitotic index in ovarian epithelial tumors]. Sichuan Da Xue Xue Bao Yi Xue Ban; 2010 Jul;41(4):575-80
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  • [Title] [Expressions of Ki67, PCNA and mitotic index in ovarian epithelial tumors].
  • OBJECTIVE: To analyze the expressions of Ki67, PCNA and mitotic index in ovarian epithelial tumors and their relationship with clinical pathological features.
  • METHODS: The expressions of Ki67, PCNA protein and mitotic index in ovarian tissues from 20 patients with normal ovarian tissues, 28 patients with ovarian benign tumors, 20 patients with borderline tumors and 109 (73 metastatic ovarian cancer) patients with malignant tumors were retrospectively tested using the American GBI immunohistochemistry two-step method.
  • The expressions of Ki67 and PCNA mRNA were also detected by in situ hybridization (ISH) in ovarian tissues from 37 patients with primary ovarian cancer, 14 patients with borderline tumors, 11 patients with benign tumors and 12 patients with normal ovarian tissues.
  • The relationship between clinical pathologic parameters and the expressions of Ki67 and, PCNA and mitotic index in human ovarian tumors was analyzed. RESULTS:.
  • (1) The expressions of Ki67 mRNA and protein in ovarian epithelial tumors was higher than in the controls (P = 0.003; P = 0.009; P = 0.001; P = 0.001).
  • The expression of Ki67 protein in serous tumor tissues was high, but low or missed in other types of tumor tissues such as malignant mixed mullerian tumor and transitional cell carcinoma (P = 0. 018).
  • No significant differences in other clinicopathological features were found.
  • CONCLUSION: Ki67 and mitotic index can serve as biomolecular markers for predicting the proliferation of malignant ovarian epithelial tumors.
  • PCNA can not discriminate between benign and malinant ovarian tumors.
  • [MeSH-major] Ki-67 Antigen / metabolism. Mitotic Index. Neoplasms, Glandular and Epithelial / metabolism. Ovarian Neoplasms / metabolism. Proliferating Cell Nuclear Antigen / metabolism
  • [MeSH-minor] Biomarkers, Tumor / biosynthesis. Carcinoma / metabolism. Carcinoma / pathology. Female. Humans

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  • (PMID = 20848772.001).
  • [ISSN] 1672-173X
  • [Journal-full-title] Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
  • [ISO-abbreviation] Sichuan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen; Ovarian epithelial cancer
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77. Jakab C, Rusvai M, Szabó Z, Szabára A, Kulka J: Expression of the claudin-4 molecule in benign and malignant canine hepatoid gland tumours. Acta Vet Hung; 2009 Dec;57(4):463-75
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  • [Title] Expression of the claudin-4 molecule in benign and malignant canine hepatoid gland tumours.
  • The present study has evaluated the expression of claudin-4 in 10 normal canine hepatoid glands and in 67 hepatoid glands with hyperplastic and neoplastic lesions.
  • The multiple small parts of epitheliomas in which the cells exhibited typical hepatoid features showed a well-localised linear circumferential membranous staining pattern for claudin-4.
  • These results suggest that low claudin-4 expression in epitheliomas is a molecular characteristic indicative of increasing cellular disorientation, detachment motility and invasion by tumour cells, and claudin-4 seems to be helpful in distinguishing undifferentiated carcinomas from differentiated carcinomas and epitheliomas of the hepatoid gland.
  • [MeSH-major] Anal Gland Neoplasms / metabolism. Dog Diseases / metabolism. Gene Expression Regulation, Neoplastic / physiology. Membrane Proteins / metabolism

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  • (PMID = 19897451.001).
  • [ISSN] 0236-6290
  • [Journal-full-title] Acta veterinaria Hungarica
  • [ISO-abbreviation] Acta Vet. Hung.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Claudin-4; 0 / Membrane Proteins
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78. Krishnanand G, Kaur M, Rao RV, Monappa V: Oncocytic variant of mucoepidermoid carcinoma of submandibular gland: an unusual clinical and morphological entity. Indian J Pathol Microbiol; 2007 Jul;50(3):538-40
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  • In this case report we describe a rare tumor--Oncocytic variant of Mucoepidermoid carcinoma of the submandibular salivary gland with a review of the literature.
  • Oncocytic metaplasia in salivary glands is a benign change that is associated with increasing age and also seen in a few salivary gland neoplasms', which include oncocytoma, Warthin's tumor, and the rare, oncocytic carcinoma.
  • The recognition of this entity is important, since most of the other primary oncocytic lesions of the salivary gland are benign.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Submandibular Gland Neoplasms / pathology

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  • (PMID = 17883126.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 10
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79. Darwood RJ, Borley NR: TEMS: an alternative method for the repair of benign recto-vaginal fistulae. Colorectal Dis; 2008 Jul;10(6):619-20
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  • [Title] TEMS: an alternative method for the repair of benign recto-vaginal fistulae.
  • METHOD: The patient was placed prone and a 25 cm rectoscope was inserted.
  • The patient was discharged 2 days later and a contrast study confirmed closure of the fistula.
  • COMPARISON WITH OTHER TECHNIQUES: TEMS allows excellent visualisation of a rectovaginal fistula compared to standard endo-anal or trans-vaginal techniques.
  • COMMENTS: TEMS is a useful technique for the repair of benign recto-vaginal fistula and has distinct advantages over conventional techniques.
  • [MeSH-minor] Adenocarcinoma / surgery. Aged. Anal Canal. Female. Humans. Rectal Neoplasms / surgery

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  • (PMID = 18294273.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] England
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80. Aniba K, Ghannane H, Lmejjati M, Ouali M, Jalal H, Ousehal A, Ait Benali S: [Benign sacrococcygeal teratoma in a child: a case report with a review of the literature]. Arch Pediatr; 2009 Nov;16(11):1467-9
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  • [Title] [Benign sacrococcygeal teratoma in a child: a case report with a review of the literature].
  • [Transliterated title] Tératome sacrococcygien bénin chez l'enfant : revue de littérature à propos d'un cas.
  • Sacrococcygeal teratomas are rare congenital tumors, generally discovered at birth.
  • These tumors are seldom observed in children.
  • Radical resection must be performed to avoid potentially malignant recurrence even if the primary lesion is benign.
  • The MRI showed a large sacrococcygeal cyst in hypointense-signal T1-weighted imaging with no contrast enhancement, and a hyperintense signal in T2-weighted imaging.
  • At surgery, the tumor was totally removed.
  • The intraoperative aspect was that of a viscous cyst.
  • [MeSH-major] Magnetic Resonance Imaging. Sacrococcygeal Region. Soft Tissue Neoplasms / congenital. Soft Tissue Neoplasms / diagnosis. Teratoma / congenital. Teratoma / diagnosis
  • [MeSH-minor] Child. Contrast Media / administration & dosage. Diagnosis, Differential. Female. Follow-Up Studies. Humans

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  • (PMID = 19748243.001).
  • [ISSN] 1769-664X
  • [Journal-full-title] Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
  • [ISO-abbreviation] Arch Pediatr
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 6
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81. Gonzalez S: Apocrine gland cyst with hemosiderotic dermatofibroma-like stroma: report of two cases. Am J Dermatopathol; 2005 Feb;27(1):36-8
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  • The first case was a 52-year-old female who presented with a nodule on the back of several years of evolution and with the clinical diagnosis of lipoma; the second case was a 41-year-old male who presented with a forehead nodule of several years of evolution with a clinical diagnosis of epidermal cyst.
  • Histologically, an ill-delimited non-encapsulated nodule composed of cystic spaces and solid areas was found.
  • The cystic spaces consisted of ductal structures and a bilayered epithelial covering with apocrine differentiation; the surrounding area showed a stroma composed of a mixture of both fibrocytes and macrophages and abundant hemosiderin granules; foci of recent hemorrhages and a more dense fibrous stroma at the periphery with typical storiform areas were also visible.
  • Both cases have shown a benign course without local recurrence in follow up until this report date.
  • [MeSH-major] Apocrine Glands / pathology. Epidermal Cyst / pathology. Hemosiderin / metabolism. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

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  • (PMID = 15677975.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9011-92-1 / Hemosiderin
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82. Nawar R, Aron D: Adrenal incidentalomas -- a continuing management dilemma. Endocr Relat Cancer; 2005 Sep;12(3):585-98
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  • Adrenal incidentalomas (AI), adrenal tumors detected through an imaging procedure done for reasons unrelated to adrenal dysfunction, is becoming a common clinical problem with the more frequent utilization of different imaging techniques.
  • Most such tumors are benign and hormonally inactive.
  • Even after a commissioned systematic review of the literature and a state of the science conference sponsored by the National Institutes of Health, the optimal strategy for hormonal screening of a patient with AI is unknown, but we anticipate further refinements and major advances in the field.
  • The benefit of making a diagnosis of a clinically significant AI must be considered in the context of the patient's overall condition and preferences.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / physiopathology. Incidental Findings
  • [MeSH-minor] Adrenal Gland Diseases / diagnosis. Adrenal Gland Diseases / etiology. Humans. National Institutes of Health (U.S.). Pheochromocytoma / diagnosis. United States

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  • (PMID = 16172193.001).
  • [ISSN] 1351-0088
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 99
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83. Yamazaki K: CD10- and CD34-positive periglandular stromal cells in pulmonary benign metastasizing leiomyoma with metaplastic adenomyomatous glands: an ultrastructural and immunohistochemical study. Virchows Arch; 2005 Mar;446(3):270-7
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  • [Title] CD10- and CD34-positive periglandular stromal cells in pulmonary benign metastasizing leiomyoma with metaplastic adenomyomatous glands: an ultrastructural and immunohistochemical study.
  • Two Japanese females, 36 years and 52 years old, with episodes of uterine leiomyoma, were operated on for pulmonary benign metastasizing leiomyomas (PBMLs) in their peripheral lung.
  • In the tumorous nodules of the PBMLs, epithelial cells with the characteristics of lung epithelial cells of type-II pneumocytes were observed, together with ciliated and non-ciliated bronchiolar epithelial cells in the entrapped and metaplastic glands.
  • [MeSH-major] Antigens, CD34 / metabolism. Leiomyoma / metabolism. Lung Neoplasms / secondary. Neprilysin / metabolism. Uterine Neoplasms / metabolism
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Microscopy, Electron, Transmission. Middle Aged

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  • (PMID = 15688167.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD34; EC 3.4.24.11 / Neprilysin
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84. Holdenrieder S, Burges A, Reich O, Spelsberg FW, Stieber P: DNA integrity in plasma and serum of patients with malignant and benign diseases. Ann N Y Acad Sci; 2008 Aug;1137:162-70
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  • [Title] DNA integrity in plasma and serum of patients with malignant and benign diseases.
  • Matched serum and plasma samples of 42 patients with various forms of cancer and 17 patients with corresponding benign diseases were analyzed.
  • DNA was isolated from 1 mL serum and plasma using the MagNA Pure LC system.
  • We found that DNA concentrations were not different in plasma (median: 4.5 ng/mL) and serum (67.1 ng/mL) of patients with benign diseases when compared with values in plasma (5.1 ng/mL) and serum (65.4 ng/mL) of cancer patients.
  • Similarly, the DNA integrity index in plasma (0.38), and serum of patients with benign diseases (0.29) was comparable to values in plasma (0.33) and serum (0.37) of cancer patients.
  • However, a combination with other markers such as DNA may enhance sensitivity for cancer detection.
  • [MeSH-major] DNA / blood. DNA, Neoplasm / blood. Neoplasms
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Area Under Curve. Biomarkers, Tumor / blood. Biomarkers, Tumor / genetics. Diagnosis, Differential. Disease. Female. Humans. Male. Middle Aged. ROC Curve. Sensitivity and Specificity

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  • (PMID = 18837942.001).
  • [ISSN] 1749-6632
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 9007-49-2 / DNA
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85. Fisenko EP: [Alterations in blood flow as a diagnostic criteria for breast cancer]. Angiol Sosud Khir; 2009;15(1):33-8
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  • The article is dedicated to one of the challenging problems, i. e., diagnosis of breast cancer by the findings of ultrasonographic Doppler examination in women with endured augmentation mammoplasty performed by means of inserting gel implants.
  • Special attention is paid to diagnosis of small tumours (less than 1.5 cm in size) and to differential diagnosis of malignant and benign neoplasms of the mammary gland with complications of gel plasty.
  • The use of Doppler ultrasonography made it possible to increase the accuracy of ultrasonographic examination in diagnosis of breast cancer by 4.5 %.
  • A highly specific sign of breast cancer, amounting to as high as 98.2 %, is local enhancement of the vascular picture within the zone of the growing tumour, including in women having sustained augmentation mammoplasty.
  • [MeSH-major] Breast Neoplasms / ultrasonography. Regional Blood Flow / physiology. Ultrasonography, Doppler, Color / methods. Ultrasonography, Mammary / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Middle Aged. Reproducibility of Results. Young Adult

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  • (PMID = 19791573.001).
  • [ISSN] 1027-6661
  • [Journal-full-title] Angiologii︠a︡ i sosudistai︠a︡ khirurgii︠a︡ = Angiology and vascular surgery
  • [ISO-abbreviation] Angiol Sosud Khir
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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86. Naz Z, Anjum S: Effect of anthropometric measurements and personal data parameters on benign prostatic hyperplasia and carcinoma prostate. J Ayub Med Coll Abbottabad; 2010 Jul-Sep;22(3):54-7
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  • [Title] Effect of anthropometric measurements and personal data parameters on benign prostatic hyperplasia and carcinoma prostate.
  • BACKGROUND: With advancing age the chances of benign prostatic hyperplasia (BPH) and carcinoma prostate (CaP) increases.
  • CONCLUSION: No significant association between other parameters and BPH, CaP cases was found, except weight, BMI and skilled labour.
  • [MeSH-major] Anthropometry / methods. Prostatic Hyperplasia / epidemiology. Prostatic Neoplasms / epidemiology


87. Sadetzki S, Chetrit A, Freedman L, Stovall M, Modan B, Novikov I: Long-term follow-up for brain tumor development after childhood exposure to ionizing radiation for tinea capitis. Radiat Res; 2005 Apr;163(4):424-32
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  • [Title] Long-term follow-up for brain tumor development after childhood exposure to ionizing radiation for tinea capitis.
  • Ionizing radiation is an established risk factor for brain tumors, yet quantitative information on the long-term risk of different types of brain tumors is sparse.
  • Our aims were to assess the risk of radiation-induced malignant brain tumors and benign meningiomas after childhood exposure and to investigate the role of potential modifiers of that risk.
  • The mean estimated radiation dose to the brain was 1.5 Gy.
  • Survival analysis using Poisson regression was performed to estimate the excess relative and absolute risks (ERR, EAR) for brain tumors.
  • After a median follow-up of 40 years, an ERR/Gy of 4.63 and 1.98 (95% CI = 2.43-9.12 and 0.73-4.69) and an EAR/Gy per 10(4) PY of 0.48 and 0.31 (95% CI = 0.28-0.73 and 0.12-0.53) were observed for benign meningiomas and malignant brain tumors, respectively.
  • The risk of both types of tumors was positively associated with dose.
  • The estimated ERR/Gy for malignant brain tumors decreased with increasing age at irradiation from 3.56 to 0.47 (P = 0.037), while no trend with age was seen for benign meningiomas.
  • The ERR for both types of tumor remains elevated at 30-plus years after exposure.
  • [MeSH-major] Brain / radiation effects. Brain Neoplasms / epidemiology. Neoplasms, Radiation-Induced / epidemiology. Radiotherapy / statistics & numerical data. Risk Assessment / methods. Tinea Capitis / epidemiology. Tinea Capitis / radiotherapy


88. Brandal P, Panagopoulos I, Bjerkehagen B, Heim S: t(19;22)(q13;q12) Translocation leading to the novel fusion gene EWSR1-ZNF444 in soft tissue myoepithelial carcinoma. Genes Chromosomes Cancer; 2009 Dec;48(12):1051-6
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  • Myoepithelial neoplasms of soft tissue have only recently been acknowledged as a separate diagnostic entity.
  • To know based on histological appearance whether these tumors are benign or malignant is often difficult, and their tumorigenic mechanisms remain poorly understood.
  • We report a myoepithelial carcinoma with an aberrant near-diploid karyotype, 43 approximately 47,XX,add(1)(p34)x2,add(3)(q27)x2,del(12)(q22),+add(18)(p11)x2,del(22)(q11),+r, found in cells cultured from a lung metastasis.
  • How the new fusion gene contributes to tumorigenesis is unknown, but the finding of an EWSR1 rearrangement suggests that this, possibly even the EWSR1-ZNF444, is a defining pathogenetic feature of at least a subset of these tumors.
  • [MeSH-minor] Adult. Female. Gene Expression Regulation, Neoplastic. Humans. Immunoenzyme Techniques. In Situ Hybridization, Fluorescence. Karyotyping. Lung Neoplasms / genetics. Lung Neoplasms / secondary. Polymerase Chain Reaction

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19760602.001).
  • [ISSN] 1098-2264
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calmodulin-Binding Proteins; 0 / EWSR1 protein, human; 0 / Kruppel-Like Transcription Factors; 0 / Oncogene Proteins, Fusion; 0 / RNA-Binding Proteins; 0 / ZNF71 protein, human
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89. Daniely M, Rona R, Kaplan T, Olsfanger S, Elboim L, Freiberger A, Lew S, Leibovitch I: Combined morphologic and fluorescence in situ hybridization analysis of voided urine samples for the detection and follow-up of bladder cancer in patients with benign urine cytology. Cancer; 2007 Dec 25;111(6):517-24
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  • [Title] Combined morphologic and fluorescence in situ hybridization analysis of voided urine samples for the detection and follow-up of bladder cancer in patients with benign urine cytology.
  • Patients with bladder cancer are closely followed with periodic cystoscopies and urine cytology analyses due to the significant risk of tumor recurrence.
  • METHODS: In the current study, the diagnostic usefulness of a combined cytology and FISH analysis approach was tested using the Duet automatic scanning system in patients with benign urine cytology who were being monitored for recurrent urothelial carcinoma or being assessed for various urologic symptoms.
  • Only 2 patients with a negative combined analysis result presented with late disease recurrence (20 months and 22 months, respectively, after the negative test).
  • Therefore, negative combined analysis was found to be predictive of a lack of disease recurrence for at least 12 months.
  • [MeSH-major] Urinary Bladder Neoplasms / pathology. Urinary Bladder Neoplasms / urine. Urine / cytology
  • [MeSH-minor] Cytodiagnosis. Female. Follow-Up Studies. Humans. In Situ Hybridization, Fluorescence. Male. Neoplasm Recurrence, Local / diagnosis. Sensitivity and Specificity

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  • (PMID = 17963263.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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90. Battista RA: Preface: radiosurgery and radiotherapy for benign skull base tumors. Otolaryngol Clin North Am; 2009 Aug;42(4):xiii-xiv
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  • [Title] Preface: radiosurgery and radiotherapy for benign skull base tumors.
  • [MeSH-major] Skull Base Neoplasms / radiotherapy. Skull Base Neoplasms / surgery

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  • (PMID = 19751865.001).
  • [ISSN] 1557-8259
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Editorial; Introductory Journal Article
  • [Publication-country] United States
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91. Vargas PA, Cheng Y, Barrett AW, Craig GT, Speight PM: Expression of Mcm-2, Ki-67 and geminin in benign and malignant salivary gland tumours. J Oral Pathol Med; 2008 May;37(5):309-18
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  • [Title] Expression of Mcm-2, Ki-67 and geminin in benign and malignant salivary gland tumours.
  • BACKGROUND: Recent studies have proposed that minichromosome maintenance (Mcm) proteins may be sensitive proliferation markers and may serve as novel biomarkers for prognostication and diagnosis of various pre-malignant and malignant lesions.
  • The aims of this study were to determine the expression of Mcm-2, Ki-67 and geminin in salivary gland (SG) tumours, and to evaluate their usefulness for diagnosis or for prediction of tumour behaviour.
  • METHODS: Tissue from 62 SG tumours was assembled in tissue microarray format.
  • RESULTS: Mcm-2 expression was higher than Ki-67 and geminin in all tumours studied.
  • LI did not correlate to tumour grade or outcome for any of the markers or tumour types.
  • CONCLUSIONS: The findings suggest that Mcm-2 may be a sensitive proliferation marker in SG tumours and may be useful for differential diagnosis between PA and CEPA, and ACC and PLGA.
  • [MeSH-major] Biomarkers, Tumor / biosynthesis. Cell Cycle Proteins / biosynthesis. Ki-67 Antigen / biosynthesis. Nuclear Proteins / biosynthesis. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / metabolism. Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / metabolism. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Acinar Cell / diagnosis. Carcinoma, Acinar Cell / metabolism. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / metabolism. Cell Proliferation. Diagnosis, Differential. Female. Geminin. Humans. Immunoenzyme Techniques. Male. Microarray Analysis. Middle Aged. Minichromosome Maintenance Complex Component 2. Neoplasm Proteins / biosynthesis

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  • (PMID = 18248354.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / GMNN protein, human; 0 / Geminin; 0 / Ki-67 Antigen; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; EC 3.6.4.12 / MCM2 protein, human; EC 3.6.4.12 / Minichromosome Maintenance Complex Component 2
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92. Auluck A, Rosin MP, Zhang L, Sumanth KN: Oral submucous fibrosis, a clinically benign but potentially malignant disease: report of 3 cases and review of the literature. J Can Dent Assoc; 2008 Oct;74(8):735-40
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  • [Title] Oral submucous fibrosis, a clinically benign but potentially malignant disease: report of 3 cases and review of the literature.
  • Dentists in western countries should enhance their knowledge of this disease as it seems to be increasing with population migration.
  • In this paper, we review the literature on OSF and present 3 cases representing different stages of the disease to help dentists make an early diagnosis and reduce the morbidity and mortality associated with this condition.
  • [MeSH-minor] Adult. Areca / adverse effects. Carcinoma, Squamous Cell / pathology. Cell Transformation, Neoplastic. Collagen / metabolism. Disease Progression. Female. Gingival Neoplasms / pathology. Glucocorticoids / administration & dosage. Humans. Injections, Intralesional. Male. Middle Aged. Precancerous Conditions / pathology. Young Adult

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  • (PMID = 18845065.001).
  • [ISSN] 1488-2159
  • [Journal-full-title] Journal (Canadian Dental Association)
  • [ISO-abbreviation] J Can Dent Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Glucocorticoids; 9007-34-5 / Collagen
  • [Number-of-references] 37
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93. Coenegrachts K, ter Beek L, Haspeslagh M, Bipat S, Stoker J, Rigauts H: Comparison of respiratory-triggered T2-weighted turbo spin-echo imaging versus breath-hold T2-weighted turbo spin-echo imaging: distinguishing benign from malignant liver lesions in patients with colorectal cancer. JBR-BTR; 2009 Jul-Aug;92(4):195-201
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  • [Title] Comparison of respiratory-triggered T2-weighted turbo spin-echo imaging versus breath-hold T2-weighted turbo spin-echo imaging: distinguishing benign from malignant liver lesions in patients with colorectal cancer.
  • [MeSH-major] Colorectal Neoplasms / pathology. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Diagnosis, Differential. Diffusion Magnetic Resonance Imaging. Female. Humans. Liver Diseases / diagnosis. Male. Middle Aged


94. Picken MM, Fresco R: Mixed epithelial and stromal tumor of the kidney: preliminary immunohistochemical and electron microscopic studies of the epithelial component. Ultrastruct Pathol; 2005 May-Aug;29(3-4):283-6
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  • [Title] Mixed epithelial and stromal tumor of the kidney: preliminary immunohistochemical and electron microscopic studies of the epithelial component.
  • Mixed epithelial and stromal tumor of the kidney is a rare biphasic tumor composed of cysts and tubules embedded in the spindle cell stroma.
  • Although the histogenesis of this tumor is unknown, it has been proposed that both components of the tumor, i.e., stromal and epithelial, are neoplastic.
  • The authors report preliminary immunohistochemical and electron microscopic studies of the epithelial component from one case of a typical, benign, mixed epithelial, and stromal tumor of the kidney.
  • By electron microscopy, some tubules had features of proximal tubular epithelium, while other tubules had features of the loop of Henle (thin segments).
  • The authors believe that in a benign tumor such morphologic heterogeneity is inconsistent with neoplastic proliferation.
  • Therefore, they postulate that in mixed epithelial and stromal tumor of the kidney the tubules are entrapped rather than neoplastic.
  • [MeSH-major] Epithelial Cells / pathology. Kidney Neoplasms / pathology. Mixed Tumor, Malignant / pathology. Stromal Cells / pathology

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  • (PMID = 16036882.001).
  • [ISSN] 0191-3123
  • [Journal-full-title] Ultrastructural pathology
  • [ISO-abbreviation] Ultrastruct Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / KRT7 protein, human; 0 / Keratin-7; 68238-35-7 / Keratins; EC 3.4.24.11 / Neprilysin
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95. Nolen B, Velikokhatnaya L, Marrangoni A, De Geest K, Lomakin A, Bast RC Jr, Lokshin A: Serum biomarker panels for the discrimination of benign from malignant cases in patients with an adnexal mass. Gynecol Oncol; 2010 Jun;117(3):440-5
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  • [Title] Serum biomarker panels for the discrimination of benign from malignant cases in patients with an adnexal mass.
  • OBJECTIVES: The diagnosis of an adnexal mass is a prevalent issue among women in the United States, although current methods of identifying those at high risk of malignancy remain insufficient.
  • Ineffective triage of women with malignant masses is associated with delayed or inappropriate treatment and a negative effect on disease outcome.
  • Our subject group consisted of women diagnosed with benign masses and early- and late-stage ovarian cancer.
  • RESULTS: More than half of the biomarkers tested were found to differ significantly between benign and malignant cases.
  • As individual markers, HE4 and CA-125 provided the greatest level of discrimination between benign and malignant cases, and the combination of these two biomarkers provided a higher level of discriminatory power than either marker considered alone.
  • Multivariate statistical analysis identified several multimarker panels that could discriminate early-stage, late-stage, and combined ovarian cancers from benign cases with similar or slightly improved SN/SP levels to the CA-125/HE4 combination; however, these larger panels could not outperform the 2-biomarker panel in an independent validation set.
  • CONCLUSIONS: Our findings serve to advance the development of blood-based screening methods for the discrimination of benign and malignant ovarian masses by confirming and expanding upon the superior utility of the CA-125/HE4 combination.

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
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  • (PMID = 20334903.001).
  • [ISSN] 1095-6859
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA098642-03; United States / NCI NIH HHS / CA / R01 CA098642; United States / NCI NIH HHS / CA / R01 CA108990; United States / NCI NIH HHS / CA / R01 CA098642-02; United States / NCI NIH HHS / CA / R01 CA098642-01A1; United States / NCI NIH HHS / CA / R01 CA108990-02; United States / NCI NIH HHS / CA / R01 CA108990-01; United States / NCI NIH HHS / CA / R01 CA108990-05; United States / NCI NIH HHS / CA / R01 CA108990-04; United States / NCI NIH HHS / CA / R01 CA108990-05S1; United States / NCI NIH HHS / CA / R01 CA098642-04; United States / NCI NIH HHS / CA / R01 CA108990-01A1; United States / NCI NIH HHS / CA / R01 CA108990-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-125 Antigen; 0 / DEFB126 protein, human; 0 / Epididymal Secretory Proteins; 0 / beta-Defensins
  • [Other-IDs] NLM/ NIHMS192224; NLM/ PMC2873171
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96. Sherrod QJ, Chiu MW, Gutierrez M: Multiple pilomatricomas: cutaneous marker for myotonic dystrophy. Dermatol Online J; 2008;14(7):22
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  • We report an interesting case of multiple pilomatricomas (MPs) in a patient with myotonic dystrophy.
  • Pilomatricoma (calcifying epithelioma of Malherbe) is a benign tumor of hair matrix derivation.
  • Since the onset of MPs may precede the signs of myotonic dystrophy, they can serve as potential early cutaneous markers for this systemic disease.
  • [MeSH-major] Biomarkers, Tumor / analysis. Hair Diseases / pathology. Myotonic Dystrophy / pathology. Pilomatrixoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 18718206.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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97. Chandra RK, Rohman GT, Walsh WE: Anterior palate sensory impairment after septal surgery. Am J Rhinol; 2008 Jan-Feb;22(1):86-8
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  • One hundred one surgeries were septoplasty by technique of submucous resection, three surgeries were septal perforation repairs using a mucosal advancement flap from the nasal floor, two surgeries were excisions of benign septal neoplasms, and one surgery was a closed reduction of a nasal septal fracture.

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  • (PMID = 18284865.001).
  • [ISSN] 1050-6586
  • [Journal-full-title] American journal of rhinology
  • [ISO-abbreviation] Am J Rhinol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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98. Mai PL, Korde L, Kramer J, Peters J, Mueller CM, Pfeiffer S, Stratakis CA, Pinto PA, Bratslavsky G, Merino M, Choyke P, Linehan WM, Greene MH: A possible new syndrome with growth-hormone secreting pituitary adenoma, colonic polyposis, lipomatosis, lentigines and renal carcinoma in association with familial testicular germ cell malignancy: A case report. J Med Case Rep; 2007 Mar 28;1:9
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  • BACKGROUND: Germ-cell testicular cancer has not been definitively linked to any known hereditary cancer susceptibility disorder.
  • Familial testicular cancer in the presence of other findings in affected and unaffected family members might indicate a previously-unidentified hereditary cancer syndrome.
  • His evaluation as part of an etiologic study of familial testicular cancer revealed multiple colon polyps (adenomatous, hyperplastic, and hamartomatous) first found in his 50 s, multiple lipomas, multiple hyperpigmented skin lesions, left kidney cancer diagnosed at age 64, and a growth-hormone producing pituitary adenoma with associated acromegaly diagnosed at age 64.
  • The patient underwent genetic testing for Cowden syndrome (PTEN gene), Carney complex (PRKAR1A gene), and multiple endocrine neoplasia syndrome type 1 (MEN1 gene); no deleterious mutations were identified.
  • DISCUSSION: The constellation of benign and malignant neoplasms in the context of this patient's familial testicular cancer raised the possibility that these might be manifestations of a known hereditary susceptibility cancer syndrome; however, genetic testing for the three syndromes that were most likely to explain these findings did not show any mutation.
  • Alternatively, this family's phenotype might represent a novel neoplasm susceptibility disorder.
  • This possibility cannot be evaluated definitively on the basis of a single case report; additional observations and studies are necessary to investigate this hypothesis further.

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  • (PMID = 17411461.001).
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CP / N02CP11019
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1847830
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99. Guitera P, Bourgeat P, Stretch JR, Scolyer RA, Ourselin S, Lean C, Thompson JF, Bourne R: Diagnostic value of 8.5 T magnetic resonance spectroscopy of benign and malignant skin lesion biopsies. Melanoma Res; 2010 Aug;20(4):311-7
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  • [Title] Diagnostic value of 8.5 T magnetic resonance spectroscopy of benign and malignant skin lesion biopsies.
  • Samples were grouped and compared according to five clinically significant distinctions: melanoma (n=38) or nonmelanoma (n=30), primary melanoma (n=33) or secondary melanoma (involved nodes and distant metastases, n=5), primary melanoma (n=33) or nevi (n=8), malignant (n=46) or nonmalignant (n=22), and melanocytic (n=46) or nonmelanocytic (n=22).
  • In all comparisons, the average magnetic resonance spectrum of each class lay within 1 standard deviation of the average spectrum of the other class.
  • Inclusion of other metabolite resonances in the analysis did not increase discrimination accuracy.
  • Tissue heterogeneity in conventionally collected full thickness skin biopsies and possible biochemical variance within individual tissue types limit classification accuracy using the methods and magnetic field strength that were earlier reported to provide accurate discrimination in other cancer types.
  • [MeSH-major] Magnetic Resonance Spectroscopy / methods. Melanoma / diagnosis. Melanoma / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology

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  • (PMID = 20626102.001).
  • [ISSN] 1473-5636
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Protons
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100. Bui MM, Bagui TK, Boulware DC, Letson DG, Nasir A, Kaiser HE, Pledger WJ, Coppola D: Altered expression of cell cycle regulatory proteins in benign and malignant bone and soft tissue neoplasms. In Vivo; 2007 Sep-Oct;21(5):729-37
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  • [Title] Altered expression of cell cycle regulatory proteins in benign and malignant bone and soft tissue neoplasms.
  • Overexpression of cyclins is believed to deregulate the cell cycle in human tumors.
  • Here the expression of G1 cyclins D1 and D3, and of Ki-67 in a variety of bone and soft tissue sarcomas was assessed as compared to adjacent normal tissue and to a subset of leiomyomas.
  • In addition, upregulation of cyclin D1 was observed in leiomyosarcomas, pleomorphic sarcomas and gastrointestinal stromal tumors, but not in liposarcomas or osteosarcomas.
  • The normal soft tissue adjacent to the tumors when present (10 cases) was negative for cyclin D1 and D3, and expressed Ki-67 in 5% of the cell nuclei.
  • CONCLUSION: The higher expression of cyclin D1 and D3 and of Ki-67 in bone and soft tissue sarcomas, as compared to leiomyomas and peritumoral normal soft tissue, suggests that high cyclin expression may contribute to deregulation of the cell cycle in bone and soft tissue tumors.
  • [MeSH-major] Bone Neoplasms / metabolism. Cell Cycle Proteins / metabolism. Cyclin D1 / metabolism. Cyclins / metabolism. Gene Expression Regulation, Neoplastic. Ki-67 Antigen / metabolism. Soft Tissue Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Line, Tumor. Cyclin D3. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 18019405.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / CCND3 protein, human; 0 / Cell Cycle Proteins; 0 / Cyclin D3; 0 / Cyclins; 0 / Ki-67 Antigen; 136601-57-5 / Cyclin D1
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