[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Items 1 to 29 of about 29
1. Gonçalves AJ, Carvalho LH, Serdeira K, Nakai MY, Malavasi TR: Comparative analysis of the prevalence of the glutathione S-transferase (GST) system in malignant and benign thyroid tumor cells. Sao Paulo Med J; 2007 Sep 6;125(5):289-91
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative analysis of the prevalence of the glutathione S-transferase (GST) system in malignant and benign thyroid tumor cells.
  • In the thyroid, the appearance of cancer has been correlated with deletion of these genes.
  • The aim of this study was to compare the frequencies of these genes in patients with benign and malignant tumors of the thyroid gland.
  • DESIGN AND SETTINGS: This was a cross-sectional clinical trial carried out in the Head and Neck Surgery Division, Faculdade de Medicina da Santa Casa de São Paulo.
  • METHODS: Samples of thyroid tissue were collected from 32 patients and divided into two groups: benign tumor (A) and malignant tumor (B).
  • RESULTS: The B group presented four cases of positive genotyping for both genes, seven positive for GSTT1 and negative for GSTM1, two negative for GSTT1 and positive for GSTM1, and only one case of double negative.
  • CONCLUSION: In this study, there was no relationship between the presence of the GSTT1 and GSTM1 genes and the benign and malignant thyroid tumors.
  • [MeSH-major] Adenocarcinoma, Follicular / genetics. Carcinoma, Papillary / genetics. Glutathione Transferase / genetics. Thyroid Neoplasms / genetics
  • [MeSH-minor] Biomarkers, Tumor / genetics. Cross-Sectional Studies. Female. Genotype. Humans. Male

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18094897.001).
  • [ISSN] 1516-3180
  • [Journal-full-title] São Paulo medical journal = Revista paulista de medicina
  • [ISO-abbreviation] Sao Paulo Med J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.5.1.- / glutathione S-transferase T1; EC 2.5.1.18 / Glutathione Transferase; EC 2.5.1.18 / glutathione S-transferase M1
  •  go-up   go-down


2. Shimizu K, Nakamura K, Kobatake S, Satomura S, Maruyama M, Tajiri J, Kato R: Discrimination of thyroglobulin from thyroid carcinoma tissue and that from benign thyroid tissues with use of competitive assay between lectin and anti-thyroglobulin antibody. Rinsho Byori; 2007 May;55(5):428-33
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Discrimination of thyroglobulin from thyroid carcinoma tissue and that from benign thyroid tissues with use of competitive assay between lectin and anti-thyroglobulin antibody.
  • Thyroglobulin is produced only by thyroid follicular cells, and has a molecular weight of 660,000 and carbohydrate content of approximately 10%.
  • The composition of carbohydrate chains on thyroglobulin from thyroid carcinoma has been reported to differ from that in normal thyroid tissue.
  • In this study, heterogeneities of carbohydrate chains on thyroglobulin obtained from thyroid tissues were investigated by competitive reaction between lectin and anti-thyroglobulin monoclonal antibody.
  • The ratio of Lens culinaris agglutinin-reactive thyroglobulin to thyroglobulin was significantly lower in thyroid carcinoma than in normal thyroid tissue, Graves' disease and benign thyroid tumor.
  • However, no differences between malignant and benign tissues were observed with the other lectins tested.
  • Differences in carbohydrate chain on thyroglobulin were observed between malignant and benign thyroid tissues.
  • [MeSH-major] Autoantibodies / immunology. Lectins / immunology. Thyroglobulin / analysis. Thyroglobulin / immunology. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Antibodies, Monoclonal / immunology. Humans. Thyroid Diseases / metabolism

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • Hazardous Substances Data Bank. THYROGLOBULIN .
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17593687.001).
  • [ISSN] 0047-1860
  • [Journal-full-title] Rinsho byori. The Japanese journal of clinical pathology
  • [ISO-abbreviation] Rinsho Byori
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Autoantibodies; 0 / Lectins; 0 / anti-thyroglobulin; 9010-34-8 / Thyroglobulin
  •  go-up   go-down


3. Shimizu K, Nakamura K, Kobatake S, Satomura S, Maruyama M, Kameko F, Tajiri J, Kato R: The clinical utility of Lens culinaris agglutinin-reactive thyroglobulin ratio in serum for distinguishing benign from malignant conditions of the thyroid. Clin Chim Acta; 2007 Apr;379(1-2):101-4
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The clinical utility of Lens culinaris agglutinin-reactive thyroglobulin ratio in serum for distinguishing benign from malignant conditions of the thyroid.
  • BACKGROUND: Traditionally, the follow-up of differentiated thyroid carcinoma consists of periodic withdrawal from L-T4-suppressive therapy to allow performance of a highly sensitive serum Tg measurement to detect recurrences.
  • We investigated Lens culinaris agglutinin-reactive thyroglobulin ratios in serum to evaluate in usefulness for detection of thyroid carcinoma.
  • METHODS: The study was conducted on 93 serum sample from 23 healthy volunteers, 32 patients with benign thyroid tumor, 28 patients with thyroid carcinoma without metastasis, and 10 patients with thyroid carcinoma with lymph node metastasis.
  • RESULTS: The Lens culinaris Agglutinin reactive thyroglobulin ratio in patients with thyroid carcinoma was significantly lower than in patients with benign thyroid tumor with serum thyroglobulin concentration >200 ng/ml.
  • Among cases of thyroid carcinoma with lymph node metastasis, Lens culinaris Agglutinin reactive thyroglobulin ratios were significantly lower than in patient with thyroid carcinoma without metastasis and those with benign tumor regardless of serum thyroglobulin concentration.
  • CONCLUSION: Measurement of Lens culinaris Agglutinin reactive thyroglobulin ratio in serum may be useful for distinguishing between thyroid carcinoma and benign thyroid tumor.
  • [MeSH-major] Biomarkers, Tumor / blood. Carcinoma / pathology. Plant Lectins / immunology. Thyroglobulin / blood. Thyroid Neoplasms / pathology
  • [MeSH-minor] Binding, Competitive. Diagnosis, Differential. Female. Humans. Immunoassay. Male

  • Genetic Alliance. consumer health - Thyroid Conditions.
  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • Hazardous Substances Data Bank. THYROGLOBULIN .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17270168.001).
  • [ISSN] 0009-8981
  • [Journal-full-title] Clinica chimica acta; international journal of clinical chemistry
  • [ISO-abbreviation] Clin. Chim. Acta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Plant Lectins; 0 / lentil lectin; 9010-34-8 / Thyroglobulin
  •  go-up   go-down


Advertisement
4. Gerhard R, Nonogaki S, Fregnani JH, Soares FA, Nagai MA: NDRG1 protein overexpression in malignant thyroid neoplasms. Clinics (Sao Paulo); 2010 Jun;65(8):757-62
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] NDRG1 protein overexpression in malignant thyroid neoplasms.
  • OBJECTIVES: The aim of this study was to examine the expression of the N-myc downstream-regulated gene 1 protein in benign and malignant lesions of the thyroid gland by immunohistochemistry.
  • Increased N-myc downstream-regulated gene 1 expression has been detected in various types of tumors, but the role of N-myc downstream-regulated gene 1 expression in thyroid lesions remains to be determined.
  • METHODS: A tissue microarray paraffin block containing 265 tissue fragments corresponding to normal thyroid, nodular goiter, follicular adenoma, papillary thyroid carcinoma (classical pattern and follicular variant), follicular carcinoma, and metastases of papillary and follicular thyroid carcinomas were analyzed by immunohistochemistry using a polyclonal anti- N-myc downstream-regulated gene 1 antibody.
  • RESULTS: The immunohistochemical expression of N-myc downstream-regulated gene 1 was higher in carcinomas compared to normal thyroid glands and nodular goiters, with higher expression in classical papillary thyroid carcinomas and metastases of thyroid carcinomas (P < 0.001).
  • A combined analysis showed higher immunohistochemical expression of NDRG1 in malignant lesions (classical pattern and follicular variant of papillary thyroid carcinomas, follicular carcinomas, and metastases of thyroid carcinomas) compared to benign thyroid lesions (goiter and follicular adenomas) (P = 0.043).
  • In thyroid carcinomas, N-myc downstream-regulated gene 1 expression was significantly correlated with a more advanced TNM stage (P = 0.007) and age, metastasis, tumor extent, and size (AMES) high-risk group (P = 0.012).
  • CONCLUSIONS: Thyroid carcinomas showed increased immunohistochemical N-myc downstream-regulated gene 1 expression compared to normal and benign thyroid lesions and is correlated with more advanced tumor stages.
  • [MeSH-major] Adenoma / metabolism. Cell Cycle Proteins / metabolism. Intracellular Signaling Peptides and Proteins / metabolism. Neoplasm Proteins / metabolism. Thyroid Neoplasms / metabolism

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387.001]
  • [Cites] Carcinogenesis. 2008 Jan;29(1):2-8 [17916902.001]
  • [Cites] Cancer Res. 2000 Feb 1;60(3):749-55 [10676663.001]
  • [Cites] Rheumatology (Oxford). 2000 Jan;39(1):43-9 [10662872.001]
  • [Cites] Mol Cell Biochem. 2002 Jan;229(1-2):35-44 [11936845.001]
  • [Cites] Am J Surg Pathol. 2002 Nov;26(11):1508-14 [12409728.001]
  • [Cites] Histochem Cell Biol. 2002 Nov;118(5):399-408 [12432451.001]
  • [Cites] Cancer Res. 2003 Apr 15;63(8):1731-6 [12702552.001]
  • [Cites] Expert Rev Mol Diagn. 2003 Jul;3(4):421-30 [12877382.001]
  • [Cites] Hum Pathol. 2003 Nov;34(11):1092-100 [14652809.001]
  • [Cites] World J Gastroenterol. 2004 Feb 15;10(4):550-4 [14966915.001]
  • [Cites] Oncogene. 2004 Jul 22;23(33):5675-81 [15184886.001]
  • [Cites] Am J Surg Pathol. 2004 Oct;28(10):1336-40 [15371949.001]
  • [Cites] BMC Genet. 2004 Sep 2;5:27 [15341671.001]
  • [Cites] J Histochem Cytochem. 1979 Aug;27(8):1131-9 [90074.001]
  • [Cites] Surgery. 1988 Dec;104(6):947-53 [3194846.001]
  • [Cites] J Pathol. 1994 Aug;173(4):371-9 [7965396.001]
  • [Cites] Nat Genet. 1996 Oct;14(2):214-7 [8841199.001]
  • [Cites] J Biol Chem. 1996 Nov 22;271(47):29659-65 [8939898.001]
  • [Cites] J Histochem Cytochem. 1999 Mar;47(3):411-20 [10026243.001]
  • [Cites] Mech Dev. 1999 May;83(1-2):39-52 [10381566.001]
  • [Cites] Biochim Biophys Acta. 1999 Jul 8;1450(3):364-73 [10395947.001]
  • [Cites] Carcinogenesis. 1999 Sep;20(9):1819-23 [10469629.001]
  • [Cites] J Biol Chem. 2004 Nov 19;279(47):48930-40 [15377670.001]
  • [Cites] Cancer Res. 2005 Mar 1;65(5):1693-9 [15753364.001]
  • [Cites] Endocr Pathol. 2005 Winter;16(4):295-309 [16627917.001]
  • [Cites] JAMA. 2006 May 10;295(18):2164-7 [16684987.001]
  • [Cites] Cancer Res. 2006 Jun 15;66(12):6233-42 [16778198.001]
  • [Cites] Dis Esophagus. 2006;19(6):454-8 [17069588.001]
  • [Cites] Mod Pathol. 2007 Jan;20(1):76-83 [17170744.001]
  • [Cites] CMAJ. 2007 Nov 20;177(11):1357-61 [18025426.001]
  • [Cites] Cancer Lett. 2008 Jun 8;264(1):36-43 [18281151.001]
  • (PMID = 20835551.001).
  • [ISSN] 1980-5322
  • [Journal-full-title] Clinics (São Paulo, Brazil)
  • [ISO-abbreviation] Clinics (Sao Paulo)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / N-myc downstream-regulated gene 1 protein; 0 / Neoplasm Proteins; Thyroid cancer, papillary
  • [Other-IDs] NLM/ PMC2933120
  • [Keywords] NOTNLM ; Immunohistochemistry / NDRG1 / Thyroid Carcinoma / Thyroid Gland / Tissue Microarray
  •  go-up   go-down


5. França SR, Caldas D, Alcebíades V 2nd, de Oliveira CA: [Mucoepidermoid carcinoma of the thyroid: a case report and literature review]. Arq Bras Endocrinol Metabol; 2006 Oct;50(5):968-76
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mucoepidermoid carcinoma of the thyroid: a case report and literature review].
  • [Transliterated title] Carcinoma mucoepidermóide de tireóide: relato de caso e revisão da literatura.
  • The mucoepidermoid carcinoma is a neoplasia that usually occurs at salivary glands, breast, pancreas and gastrointestinal tract.
  • The primary occurrence on thyroid gland is rare and only 33 cases were previously published.
  • Although the majority of cases of mucoepidermoid carcinoma of the thyroid (MECT) show a benign evolution, this paper describes a patient with an aggressive tumor.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Carcinoma, Papillary / secondary. Thyroid Neoplasms / pathology
  • [MeSH-minor] Calcitonin / analysis. Female. Humans. Middle Aged. Mucins / metabolism. Neoplasm Recurrence, Local / pathology. Prognosis. Thyroid Gland / pathology. Thyroidectomy. Whole Body Imaging

  • Genetic Alliance. consumer health - Mucoepidermoid carcinoma.
  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • Hazardous Substances Data Bank. Calcitonin .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17160225.001).
  • [ISSN] 0004-2730
  • [Journal-full-title] Arquivos brasileiros de endocrinologia e metabologia
  • [ISO-abbreviation] Arq Bras Endocrinol Metabol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Mucins; 9007-12-9 / Calcitonin
  • [Number-of-references] 26
  •  go-up   go-down


6. Chen HC, Jen YM, Wang CH, Lee JC, Lin YS: Etiology of vocal cord paralysis. ORL J Otorhinolaryngol Relat Spec; 2007;69(3):167-71
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Vocal cord paralysis (VCP) is a sign of a certain underlying disease, a diagnosis which can be attributed to various causes.
  • In males, neoplasm was the most common cause occurring in 63 of 176 males, whereas surgery was most frequent in 59 of 115 females.
  • The possibility of a neoplasm must be ruled out before VCP is labeled idiopathic.
  • A benign thyroid tumor could also cause VCP.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Infant. Laryngeal Neoplasms / complications. Laryngeal Neoplasms / epidemiology. Male. Middle Aged. Prevalence. Radiation Injuries / complications. Radiation Injuries / epidemiology. Retrospective Studies

  • Genetic Alliance. consumer health - paralysis.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright (c) 2007 S. Karger AG, Basel.
  • (PMID = 17264533.001).
  • [ISSN] 0301-1569
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  •  go-up   go-down


7. Kebebew E, Peng M, Reiff E, Duh QY, Clark OH, McMillan A: ECM1 and TMPRSS4 are diagnostic markers of malignant thyroid neoplasms and improve the accuracy of fine needle aspiration biopsy. Ann Surg; 2005 Sep;242(3):353-61; discussion 361-3
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] ECM1 and TMPRSS4 are diagnostic markers of malignant thyroid neoplasms and improve the accuracy of fine needle aspiration biopsy.
  • OBJECTIVE: The objective of this study was to determine whether genes that regulate cellular invasion and metastasis are differentially expressed and could serve as diagnostic markers of malignant thyroid nodules.
  • SUMMARY AND BACKGROUND DATA: Patients whose thyroid nodules have indeterminate or suspicious cytologic features on fine needle aspiration (FNA) biopsy require thyroidectomy because of a 20% to 30% risk of thyroid cancer.
  • METHODS: Differentially expressed genes (2-fold higher or lower) in malignant versus benign thyroid neoplasms were identified by extracellular matrix and adhesion molecule cDNA array analysis and confirmed by real-time quantitative polymerase chain reaction (PCR).
  • RESULTS: By cDNA array analysis, ADAMTS8, ECM1, MMP8, PLAU, SELP, and TMPRSS4 were upregulated, and by quantitative PCR, ECM1, SELP, and TMPRSS4 mRNA expression was higher in malignant (n = 57) than in benign (n = 38) thyroid neoplasms (P< 0.002).
  • ECM1 and TMPRSS4 mRNA expression levels were independent predictors of a malignant thyroid neoplasm (P < 0.003).
  • The level of ECM1 mRNA expression was higher in TNM stage I differentiated thyroid cancers than in stage II and III tumors (P < or = 0.031).
  • CONCLUSIONS: ECM1 and TMPRSS4 are excellent diagnostic markers of malignant thyroid nodules and may be used to improve the diagnostic accuracy of FNA biopsy.
  • ECM1 is also a marker of the extent of disease in differentiated thyroid cancers.
  • [MeSH-major] Biomarkers, Tumor / genetics. Extracellular Matrix Proteins / genetics. Membrane Proteins / genetics. Serine Endopeptidases / genetics. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / genetics
  • [MeSH-minor] Biopsy, Fine-Needle. Gene Expression. Humans. Neoplasm Invasiveness. Neoplasm Metastasis. Oligonucleotide Array Sequence Analysis

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • COS Scholar Universe. author profiles.
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Clin Endocrinol Metab. 1999 Mar;84(3):951-5 [10084577.001]
  • [Cites] J Pathol. 1998 Nov;186(3):287-91 [10211118.001]
  • [Cites] Histopathology. 1999 May;34(5):453-61 [10231421.001]
  • [Cites] Am J Surg Pathol. 1999 Jun;23(6):678-85 [10366150.001]
  • [Cites] BMC Bioinformatics. 2004 Oct 25;5:159 [15504239.001]
  • [Cites] World J Surg. 2004 Nov;28(11):1099-102 [15490050.001]
  • [Cites] Cancer Res. 2000 May 15;60(10):2602-6 [10825129.001]
  • [Cites] Science. 2000 Aug 25;289(5483):1357-60 [10958784.001]
  • [Cites] Cancer. 2000 Dec 25;90(6):335-41 [11156516.001]
  • [Cites] Bone. 2001 Jan;28(1):14-20 [11165938.001]
  • [Cites] Curr Opin Genet Dev. 2001 Feb;11(1):41-7 [11163149.001]
  • [Cites] FASEB J. 2001 Apr;15(6):988-94 [11292659.001]
  • [Cites] J Clin Endocrinol Metab. 2001 May;86(5):2187-90 [11344225.001]
  • [Cites] Thyroid. 2001 Aug;11(8):783-7 [11525273.001]
  • [Cites] Trends Biotechnol. 2001 Nov;19(11):463-8 [11602311.001]
  • [Cites] J Clin Endocrinol Metab. 2001 Nov;86(11):5152-8 [11701669.001]
  • [Cites] Endocr Pathol. 2001 Fall;12(3):275-9 [11740048.001]
  • [Cites] Diagn Cytopathol. 2002 Jan;26(1):41-4 [11782086.001]
  • [Cites] J Natl Cancer Inst. 2002 Apr 3;94(7):513-21 [11929952.001]
  • [Cites] Int J Biol Markers. 2002 Jan-Mar;17(1):56-62 [11936588.001]
  • [Cites] Histopathology. 2002 Feb;40(2):133-42 [11952857.001]
  • [Cites] Cancer Res. 2004 Apr 15;64(8):2898-903 [15087409.001]
  • [Cites] Thyroid. 2004 Apr;14(4):287-93 [15142362.001]
  • [Cites] Surg Clin North Am. 2004 Jun;84(3):907-19 [15145242.001]
  • [Cites] Cancer Res. 2004 Jun 1;64(11):3780-9 [15172984.001]
  • [Cites] Cancer. 2004 Jul 1;101(1):3-27 [15221985.001]
  • [Cites] Endocrinol Jpn. 1990 Apr;37(2):247-54 [1699752.001]
  • [Cites] Diagn Cytopathol. 1992;8(1):23-7 [1551363.001]
  • [Cites] Blood Coagul Fibrinolysis. 2001 Jan;12(1):43-50 [11229826.001]
  • [Cites] J Immunol Methods. 2001 Apr1;250(1-2):3-13 [11251218.001]
  • [Cites] J Clin Endocrinol Metab. 2004 Jul;89(7):3214-23 [15240595.001]
  • [Cites] Endocr J. 2004 Jun;51(3):361-6 [15256783.001]
  • [Cites] Curr Med Chem. 2004 Aug;11(16):2153-60 [15279555.001]
  • [Cites] Br J Cancer. 2004 Aug 16;91(4):732-8 [15238980.001]
  • [Cites] Virchows Arch. 2004 Aug;445(2):183-8 [15252732.001]
  • [Cites] Ann Surg. 2004 Sep;240(3):425-36; discussion 436-7 [15319714.001]
  • [Cites] J Clin Oncol. 2004 Sep 1;22(17):3531-9 [15337802.001]
  • [Cites] Clin Cancer Res. 2004 Sep 1;10(17):5762-8 [15355904.001]
  • [Cites] Eur J Endocrinol. 2004 Sep;151(3):367-74 [15362967.001]
  • [Cites] J Clin Endocrinol Metab. 2004 Oct;89(10):5175-80 [15472223.001]
  • [Cites] Am J Clin Pathol. 2004 Oct;122(4):524-31 [15487449.001]
  • [Cites] Histopathology. 1987 Jul;11(7):723-31 [3623436.001]
  • [Cites] Cancer Res. 1988 Oct 1;48(19):5503-9 [3046740.001]
  • [Cites] Ann Intern Med. 1993 Feb 15;118(4):282-9 [8420446.001]
  • [Cites] N Engl J Med. 1993 Feb 25;328(8):553-9 [8426623.001]
  • [Cites] Mayo Clin Proc. 1993 Apr;68(4):343-8 [8455392.001]
  • [Cites] Clin Lab Med. 1993 Sep;13(3):699-709 [8222583.001]
  • [Cites] Mod Pathol. 1994 Apr;7(3):295-300 [7520169.001]
  • [Cites] Cancer Res. 1994 Sep 1;54(17):4744-9 [8062273.001]
  • [Cites] Mod Pathol. 1994 Jun;7(5):529-32 [7937716.001]
  • [Cites] Surgery. 1994 Dec;116(6):1054-60 [7985087.001]
  • [Cites] Cancer Lett. 1996 May 15;103(1):57-63 [8616809.001]
  • [Cites] Acta Cytol. 1996 May-Jun;40(3):408-13 [8669170.001]
  • [Cites] Dermatology. 1996;192(2):89-93 [8829517.001]
  • [Cites] Diagn Cytopathol. 1996 Jun;14(4):287-91 [8725126.001]
  • [Cites] Histochem Cell Biol. 1996 Dec;106(6):551-62 [8985743.001]
  • [Cites] Laryngoscope. 1997 Jan;107(1):95-100 [9001272.001]
  • [Cites] Pathol Int. 1997 Oct;47(10):673-9 [9361100.001]
  • [Cites] Oncol Rep. 2002 May-Jun;9(3):539-44 [11956624.001]
  • [Cites] Arch Pathol Lab Med. 2002 Jun;126(6):710-3 [12033961.001]
  • [Cites] Exp Hematol. 2002 Jun;30(6):503-12 [12063017.001]
  • [Cites] Endocr Pathol. 2002 Spring;13(1):3-16 [12114746.001]
  • [Cites] Biotechniques. 2002 Jul;33(1):108, 110, 112-3, passim [12139235.001]
  • [Cites] J Clin Endocrinol Metab. 2002 Aug;87(8):3947-52 [12161538.001]
  • [Cites] Am J Clin Pathol. 2002 Aug;118(2):165-6 [12162672.001]
  • [Cites] Am J Surg Pathol. 2002 Aug;26(8):1016-23 [12170088.001]
  • [Cites] Histopathology. 2002 Sep;41(3):236-43 [12207785.001]
  • [Cites] Mod Pathol. 2002 Dec;15(12):1294-301 [12481010.001]
  • [Cites] J Clin Endocrinol Metab. 2003 Jan;88(1):354-7 [12519876.001]
  • [Cites] Ann N Y Acad Sci. 2002 Dec;975:24-32 [12538151.001]
  • [Cites] Cancer Lett. 2003 Mar 10;191(2):223-7 [12618337.001]
  • [Cites] Endocr Pathol. 2002 Winter;13(4):271-88 [12665646.001]
  • [Cites] Endocr Pathol. 2002 Winter;13(4):301-11 [12665648.001]
  • [Cites] J Biol Chem. 2003 May 9;278(19):17491-9 [12604605.001]
  • [Cites] Clin Cancer Res. 2003 May;9(5):1792-800 [12738736.001]
  • [Cites] Cancer Metastasis Rev. 2003 Jun-Sep;22(2-3):237-58 [12784999.001]
  • [Cites] Biostatistics. 2003 Jul;4(3):465-77 [12925512.001]
  • [Cites] J Clin Endocrinol Metab. 2003 Sep;88(9):4440-5 [12970322.001]
  • [Cites] Cancer Lett. 2003 Oct 8;200(1):57-67 [14550953.001]
  • [Cites] Pol J Pathol. 2003;54(2):111-5 [14575419.001]
  • [Cites] BMC Bioinformatics. 2002 Aug 23;3:22 [12194703.001]
  • [Cites] Eur J Endocrinol. 2003 Nov;149(5):449-53 [14585093.001]
  • [Cites] Curr Mol Med. 2003 Nov;3(7):659-71 [14601640.001]
  • [Cites] Tumori. 2003 Sep-Oct;89(5):517-9 [14870775.001]
  • [Cites] Physiol Genomics. 2004 Feb 13;16(3):361-70 [14645736.001]
  • [Cites] FASEB J. 2004 Mar;18(3):560-1 [14715705.001]
  • [Cites] Virchows Arch. 2004 Apr;444(4):309-12 [14999471.001]
  • [Cites] Matrix Biol. 1997 Nov;16(5):289-92 [9501329.001]
  • [Cites] Mod Pathol. 1998 Feb;11(2):169-74 [9504687.001]
  • [Cites] Thyroid. 1998 May;8(5):377-83 [9623727.001]
  • [Cites] Cancer Res. 1998 Jul 15;58(14):3015-20 [9679965.001]
  • [Cites] Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9325-30 [9689079.001]
  • [Cites] Thyroid. 1998 Nov;8(11):981-7 [9848710.001]
  • [Cites] Int J Cancer. 1999 Jan 5;80(1):32-8 [9935226.001]
  • (PMID = 16135921.001).
  • [ISSN] 0003-4932
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / ECM1 protein, human; 0 / Extracellular Matrix Proteins; 0 / Membrane Proteins; EC 3.4.21.- / Serine Endopeptidases; EC 3.4.21.- / transmembrane serine protease 2, human
  • [Other-IDs] NLM/ PMC1357743
  •  go-up   go-down


8. Tischler V, Fritzsche FR, Wild PJ, Stephan C, Seifert HH, Riener MO, Hermanns T, Mortezavi A, Gerhardt J, Schraml P, Jung K, Moch H, Soltermann A, Kristiansen G: Periostin is up-regulated in high grade and high stage prostate cancer. BMC Cancer; 2010;10:273
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Metastatic prostate cancers (n = 20), hormone refractory prostate cancers (n = 19) and benign prostatic tissues (n = 38) were also analyzed.
  • RESULTS: In total, strong epithelial periostin expression was detectable in 142 of 418 (34.0%) of prostate carcinomas and in 11 of 38 benign prostate glands (28.9%).
  • Increased periostin expression in carcinoma cells was significantly associated with high Gleason score (p < 0.01) and advanced tumour stage (p < 0.05) in the test cohort.
  • Whereas periostin expression was weak or absent in the stroma around normal prostate glands, strong periostin expression in tumour stroma was found in most primary and metastatic prostate cancers.
  • CONCLUSIONS: Our data indicate that periostin up-regulation is related to increased tumour aggressiveness in prostate cancer and might be a promising target for therapeutical interventions in primary and metastatic prostate cancer.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cell Adhesion Molecules / analysis. Prostatic Neoplasms / chemistry
  • [MeSH-minor] Aged. Chi-Square Distribution. Cohort Studies. Epithelial Cells / chemistry. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Prognosis. Prostate-Specific Antigen / analysis. Stromal Cells / chemistry. Time Factors. Up-Regulation

  • Genetic Alliance. consumer health - Prostate cancer.
  • MedlinePlus Health Information. consumer health - Prostate Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Cell Biochem. 2002;86(4):792-804 [12210745.001]
  • [Cites] Mech Dev. 2001 May;103(1-2):183-8 [11335131.001]
  • [Cites] Jpn J Cancer Res. 2001 Aug;92(8):869-73 [11509119.001]
  • [Cites] Cancer. 2001 Aug 15;92(4):843-8 [11550156.001]
  • [Cites] Cancer Lett. 2001 Oct 22;172(1):37-42 [11595127.001]
  • [Cites] J Pediatr Surg. 2002 Sep;37(9):1293-7 [12194119.001]
  • [Cites] Cell Tissue Res. 2003 Jun;312(3):345-51 [12761672.001]
  • [Cites] Arch Otolaryngol Head Neck Surg. 2003 Jul;129(7):754-9 [12874078.001]
  • [Cites] Dev Dyn. 2004 Apr;229(4):857-68 [15042709.001]
  • [Cites] Mol Cell Biol. 2004 May;24(9):3992-4003 [15082792.001]
  • [Cites] Cancer Cell. 2004 Apr;5(4):329-39 [15093540.001]
  • [Cites] J Orthop Res. 2004 May;22(3):520-5 [15099630.001]
  • [Cites] J Appl Physiol (1985). 2004 Oct;97(4):1550-8; discussion 1549 [15121739.001]
  • [Cites] Biochem J. 1993 Aug 15;294 ( Pt 1):271-8 [8363580.001]
  • [Cites] J Bone Miner Res. 1999 Jul;14(7):1239-49 [10404027.001]
  • [Cites] Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):77-83 [15514205.001]
  • [Cites] Anat Rec A Discov Mol Cell Evol Biol. 2005 Dec;287(2):1205-12 [16240445.001]
  • [Cites] Thyroid. 2006 Feb;16(2):161-75 [16676402.001]
  • [Cites] J Biol Chem. 2006 Jul 14;281(28):19700-8 [16702213.001]
  • [Cites] Cancer Res. 2006 Jul 15;66(14):6928-35 [16849536.001]
  • [Cites] Mol Cell Proteomics. 2006 Nov;5(11):2083-91 [16861259.001]
  • [Cites] Br J Cancer. 2006 Nov 20;95(10):1396-403 [17060937.001]
  • [Cites] Breast Cancer Res Treat. 2007 Jan;101(1):83-93 [16807673.001]
  • [Cites] Oncogene. 2007 Mar 29;26(14):2082-94 [17043657.001]
  • [Cites] Gastroenterology. 2007 Apr;132(4):1447-64 [17408641.001]
  • [Cites] Histol Histopathol. 2007 Oct;22(10):1167-74 [17616943.001]
  • [Cites] J Cell Physiol. 2007 Nov;213(2):374-83 [17680632.001]
  • [Cites] World J Gastroenterol. 2007 Oct 21;13(39):5261-6 [17876898.001]
  • [Cites] Int J Urol. 2007 Nov;14(11):1034-9 [17956532.001]
  • [Cites] Br J Cancer. 2008 Feb 12;98(3):604-10 [18212746.001]
  • [Cites] J Exp Med. 2008 Feb 18;205(2):295-303 [18208976.001]
  • [Cites] J Clin Pathol. 2008 Apr;61(4):494-8 [17938160.001]
  • [Cites] Cancer Res. 2008 Apr 1;68(7):2479-88 [18381457.001]
  • [Cites] Int J Cancer. 2008 Jun 15;122(12):2707-18 [18381746.001]
  • [Cites] Cancer. 2008 Apr 25;114(2):124-33 [18327805.001]
  • [Cites] J Endocrinol. 2008 May;197(2):401-8 [18434370.001]
  • [Cites] Stem Cells. 2008 Jun;26(6):1425-35 [18403754.001]
  • [Cites] J Histochem Cytochem. 2008 Aug;56(8):753-64 [18443362.001]
  • [Cites] Mod Pathol. 2008 Aug;21(8):1044-53 [18487994.001]
  • [Cites] Eur Urol. 2008 Nov;54(5):1097-106 [18061337.001]
  • [Cites] Clin Cancer Res. 2008 Nov 15;14(22):7430-7 [19010860.001]
  • [Cites] Prostate. 2009 Sep 15;69(13):1398-403 [19479898.001]
  • [Cites] Histopathology. 2010 Apr;56(5):600-6 [20459570.001]
  • [Cites] Cancer Res. 2002 Sep 15;62(18):5358-64 [12235007.001]
  • (PMID = 20534149.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Adhesion Molecules; 0 / POSTN protein, human; EC 3.4.21.77 / Prostate-Specific Antigen
  • [Other-IDs] NLM/ PMC2903527
  •  go-up   go-down


9. Kebebew E, Peng M, Reiff E, Duh QY, Clark OH, McMillan A: Diagnostic and prognostic value of angiogenesis-modulating genes in malignant thyroid neoplasms. Surgery; 2005 Dec;138(6):1102-9; discussion 1109-10
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic and prognostic value of angiogenesis-modulating genes in malignant thyroid neoplasms.
  • We postulated that expression analysis of genes that modulate angiogenesis would identify differentially expressed genes that would help to distinguish benign from malignant thyroid neoplasms and serve as markers of aggressive differentiated thyroid cancer.
  • METHODS: A complementary DNA (cDNA) array with 96 genes that modulate angiogenesis was used to identify differentially expressed genes (2-fold higher or lower) in malignant versus benign thyroid neoplasms.
  • Real-time quantitative polymerase chain reaction was used to confirm cDNA array expression data in 123 patients (4 normal thyroid, 26 hyperplastic nodules, 27 follicular adenomas, 23 follicular cancers, 18 follicular variant of papillary cancers, 25 papillary cancers).
  • RESULTS: Twenty-two genes were upregulated in malignant thyroid neoplasms by cDNA array analysis, but only 13 genes had higher messenger RNA (mRNA) expression levels in malignant than in benign thyroid neoplasms by real-time quantitative polymerase chain reaction (P < or = .04).
  • Of the 13 differentially expressed genes, the combined use of angiopoietin 2 (ANGPT2) and tissue inhibitor of metalloproteinase 1 (TIMP1) mRNA expression levels was best for distinguishing malignant from benign thyroid neoplasms, with a sensitivity of 90%, specificity of 85%, positive predictive value of 75%, and negative predictive value of 94%.
  • Epidermal growth factor receptor and ephrin B2 mRNA expression was elevated in higher TNM stage neoplasms and in patients with high-risk AMES (Age, distant Metastasis, Extrathyroidal invasion, and tumor Size) differentiated thyroid cancers (P < or = .005).
  • CONCLUSIONS: Angiopoietin 2 and tissue inhibitor of metalloproteinase 1 are diagnostic markers of malignant thyroid nodules and could improve the diagnostic accuracy of FNA biopsy.
  • Epidermal growth factor receptor and ephrin B2 are markers of aggressive differentiated thyroid cancer.
  • [MeSH-major] Adenocarcinoma, Follicular / genetics. Adenoma / genetics. Angiogenic Proteins / genetics. Carcinoma, Papillary / genetics. Carcinoma, Papillary, Follicular / genetics. Thyroid Neoplasms / genetics. Thyroid Nodule / genetics


10. Liu Z, Liu D, Bojdani E, El-Naggar AK, Vasko V, Xing M: IQGAP1 plays an important role in the invasiveness of thyroid cancer. Clin Cancer Res; 2010 Dec 15;16(24):6009-18
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] IQGAP1 plays an important role in the invasiveness of thyroid cancer.
  • PURPOSE: This study was designed to explore the role of IQGAP1 in the invasiveness of thyroid cancer and its potential as a novel prognostic marker and therapeutic target in this cancer.
  • EXPERIMENTAL DESIGN: We examined IQGAP1 copy gain and its relationship with clinicopathologic outcomes of thyroid cancer and investigated its role in cell invasion and molecules involved in the process.
  • RESULTS: We found IQGAP1 copy number (CN) gain ≥ 3 in 1 of 30 (3%), 24 of 74 (32%), 44 of 107 (41%), 8 of 16 (50%), and 27 of 41 (66%) of benign thyroid tumor, follicular variant papillary thyroid cancer (FVPTC), follicular thyroid cancer (FTC), tall cell papillary thyroid cancer (PTC), and anaplastic thyroid cancer, respectively, in the increasing order of invasiveness of these tumors.
  • A similar tumor distribution trend of CN ≥ 4 was also seen.
  • The siRNA knockdown of IQGAP1 dramatically inhibited thyroid cancer cell invasion and colony formation.
  • This provided a mechanism for the invasive role of IQGAP1 in thyroid cancer.
  • CONCLUSIONS: IQGAP1, through genetic copy gain, plays an important role in the invasiveness of thyroid cancer and may represent a novel prognostic marker and therapeutic target for this cancer.

  • Genetic Alliance. consumer health - Thyroid Cancer.
  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] ©2010 AACR.
  • [Cites] Clin Cancer Res. 2007 Feb 15;13(4):1161-70 [17317825.001]
  • [Cites] Mol Cell Endocrinol. 2010 May 28;321(1):86-93 [19883729.001]
  • [Cites] Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10465-9 [17563371.001]
  • [Cites] Clin Transl Oncol. 2007 Nov;9(11):686-93 [18055323.001]
  • [Cites] Endocr Rev. 2007 Dec;28(7):742-62 [17940185.001]
  • [Cites] J Clin Endocrinol Metab. 2008 Feb;93(2):611-8 [18000091.001]
  • [Cites] Endocrinol Metab Clin North Am. 2008 Jun;37(2):333-62, viii [18502330.001]
  • [Cites] Nat Cell Biol. 2008 Aug;10(8):971-8 [18604197.001]
  • [Cites] J Hum Genet. 2001;46(1):21-5 [11289714.001]
  • [Cites] J Cell Biol. 2001 May 28;153(5):1049-60 [11381089.001]
  • [Cites] Cancer Lett. 2002 Feb 8;176(1):101-9 [11790459.001]
  • [Cites] Cancer. 2003 Mar 1;97(5):1181-5 [12599223.001]
  • [Cites] EMBO Rep. 2003 Jun;4(6):571-4 [12776176.001]
  • [Cites] J Biol Chem. 2004 Apr 23;279(17):17329-37 [14970219.001]
  • [Cites] Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10380-5 [15240889.001]
  • [Cites] J Biol Chem. 1994 Aug 12;269(32):20517-21 [8051149.001]
  • [Cites] Science. 1998 Aug 7;281(5378):832-5 [9694656.001]
  • [Cites] J Biol Chem. 1999 Jan 1;274(1):464-70 [9867866.001]
  • [Cites] Cancer. 1998 Dec 15;83(12):2638-48 [9874472.001]
  • [Cites] Genes Chromosomes Cancer. 2005 Mar;42(3):280-6 [15611933.001]
  • [Cites] J Clin Endocrinol Metab. 2005 Aug;90(8):4688-93 [15928251.001]
  • [Cites] Mol Cell Biol. 2005 Sep;25(18):7940-52 [16135787.001]
  • [Cites] Trends Cell Biol. 2006 May;16(5):242-9 [16595175.001]
  • [Cites] Cancer Lett. 2006 Nov 8;243(1):120-7 [16387427.001]
  • [Cites] J Clin Endocrinol Metab. 2008 Aug;93(8):3106-16 [18492751.001]
  • [Cites] J Clin Endocrinol Metab. 2008 Nov;93(11):4331-41 [18713817.001]
  • [Cites] Otolaryngol Clin North Am. 2008 Dec;41(6):1135-46, ix [19040974.001]
  • [Cites] Rev Med Chir Soc Med Nat Iasi. 2008 Apr-Jun;112(2):432-6 [19295016.001]
  • [Cites] Eur J Endocrinol. 2009 Apr;160(4):619-24 [19158232.001]
  • [Cites] J Clin Endocrinol Metab. 2009 Jun;94(6):2199-203 [19293266.001]
  • [Cites] FEBS Lett. 2009 Jun 18;583(12):1817-24 [19433088.001]
  • [Cites] Cell Signal. 2009 Oct;21(10):1471-8 [19269319.001]
  • [Cites] PLoS One. 2009;4(7):e6200 [19593429.001]
  • [Cites] J Clin Endocrinol Metab. 2007 Jun;92(6):2264-71 [17374713.001]
  • (PMID = 20959410.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA113507-05; United States / NCI NIH HHS / CA / R01 CA113507; United States / NCI NIH HHS / CA / R0-1 CA113507; United States / NCI NIH HHS / CA / R01 CA113507-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cadherins; 0 / IQ motif containing GTPase activating protein 1; 0 / RNA, Small Interfering; 0 / ras GTPase-Activating Proteins; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Oncogene Protein v-akt; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases
  • [Other-IDs] NLM/ NIHMS242709; NLM/ PMC3005072
  •  go-up   go-down


11. Assaad A, Voeghtly L, Hunt JL: Thyroidectomies from patients with history of therapeutic radiation during childhood and adolescence have a unique mutational profile. Mod Pathol; 2008 Sep;21(9):1176-82
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Radiation in childhood is a known risk factor for thyroid carcinoma, but may also be related to benign nodular hyperplasias.
  • Radiation in childhood was associated with both benign nodular disease and carcinomas of the thyroid.
  • The frequency of allelic loss was very high in all lesions in these patients, as compared to control thyroid glands.
  • These data from human thyroids support prior cell culture experiments and show that radiation induces genetic mutational damage even in benign proliferative processes in these thyroids.
  • [MeSH-major] DNA Mutational Analysis. Laryngeal Neoplasms / radiotherapy. Neoplasms, Radiation-Induced / genetics. Thyroid Neoplasms / genetics. Thyroidectomy
  • [MeSH-minor] Adenocarcinoma, Papillary / etiology. Adenocarcinoma, Papillary / genetics. Adenocarcinoma, Papillary / surgery. Adenoma / etiology. Adenoma / genetics. Adenoma / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Child. DNA, Neoplasm / analysis. Electrophoresis, Capillary. Female. Humans. Loss of Heterozygosity. Male. Middle Aged. Mutation. Nucleic Acid Hybridization. Polymerase Chain Reaction. Proto-Oncogene Proteins B-raf / genetics. Proto-Oncogene Proteins B-raf / metabolism

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18587320.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
  •  go-up   go-down


12. Krause K, Karger S, Sheu SY, Aigner T, Kursawe R, Gimm O, Schmid KW, Dralle H, Fuhrer D: Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis. J Endocrinol; 2008 Aug;198(2):291-9
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis.
  • We have recently found an increased expression of amyloid precursor protein (APP) in cold thyroid nodules that are difficult to classify as a truly benign thyroid neoplasm or a lesion with the potential for further dedifferentiation.
  • Since differences in APP activity have been found in other human cancers, we asked whether thyroid carcinogenesis might be associated with an altered APP expression and function.
  • APP regulation was studied in vitro in differentiated (FRTL-5) and dedifferentiated follicular thyroid carcinomas (FTC-133) thyroid cells after specific inhibition or activation of the cAMP-PKA, the PI3K/AKT or the protein kinase c (PKC) cascades.
  • In vivo analysis of APP expression and downstream signalling was performed in benign and malignant thyroid tissues.
  • We found that upregulation of APP expression and sAPP secretion is induced by TSH in differentiated thyroid cells and by insulin in thyroid cancer cells.
  • Thyroid cancers are characterized by APP upregulation, increased membrane targeting of the APP ectodomain and significantly increased mRNA levels of the APP scaffold proteins JIP1, ShcA and Fe65.
  • [MeSH-major] Amyloid beta-Protein Precursor / physiology. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Adaptor Proteins, Signal Transducing / genetics. Animals. Blotting, Western. Cell Line. Cell Line, Tumor. Gene Expression / drug effects. Humans. Immunohistochemistry. In Vitro Techniques. Insulin / pharmacology. Microscopy, Confocal. Nerve Tissue Proteins / genetics. Nuclear Proteins / genetics. Polymerase Chain Reaction. Protein Transport / drug effects. Rats. Reverse Transcriptase Polymerase Chain Reaction. Shc Signaling Adaptor Proteins / genetics. Thyroid Gland / drug effects. Thyroid Gland / metabolism. Thyroid Gland / pathology. Thyrotropin / pharmacology

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18480379.001).
  • [ISSN] 1479-6805
  • [Journal-full-title] The Journal of endocrinology
  • [ISO-abbreviation] J. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / APBB1 protein, human; 0 / Adaptor Proteins, Signal Transducing; 0 / Amyloid beta-Protein Precursor; 0 / Insulin; 0 / MAPK8IP1 protein, human; 0 / Nerve Tissue Proteins; 0 / Nuclear Proteins; 0 / SHC1 protein, human; 0 / Shc Signaling Adaptor Proteins; 9002-71-5 / Thyrotropin
  •  go-up   go-down


13. Larumbe A, Iglesias ME, Illarramendi JJ, Córdoba A, Gállego M: [Acral keratoses and inverted follicular keratosis presenting Cowden disease]. Actas Dermosifiliogr; 2007 Jul-Aug;98(6):425-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Queratosis acras y queratosis folicular invertida como manifestación de la enfermedad de Cowden.
  • Cowden disease is a rare genetic disorder characterized by the presence of multiple hamartomas in the skin, thyroid, breast, nervous system and gastrointestinal tract.
  • Breast and thyroid neoplasms (benign and malignant) develop in up to two thirds of patients.
  • [MeSH-major] Hamartoma Syndrome, Multiple / diagnosis. Keratosis / etiology
  • [MeSH-minor] Adenocarcinoma / genetics. Breast Neoplasms / genetics. Endometrial Neoplasms / genetics. Female. Goiter, Nodular / genetics. Humans. Lymphangioma / etiology. Mastectomy. Middle Aged. Postoperative Complications / etiology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17663933.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  •  go-up   go-down


14. Lappinga PJ, Kip NS, Jin L, Lloyd RV, Henry MR, Zhang J, Nassar A: HMGA2 gene expression analysis performed on cytologic smears to distinguish benign from malignant thyroid nodules. Cancer Cytopathol; 2010 Oct 25;118(5):287-97
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] HMGA2 gene expression analysis performed on cytologic smears to distinguish benign from malignant thyroid nodules.
  • BACKGROUND: Up to 80% of thyroid nodules with an indeterminate diagnosis on fine-needle aspiration (FNA) (eg, "suspicious for follicular neoplasm") prove to be benign at the time of surgical resection.
  • Ancillary tests in current use are limited in their ability to improve the preoperative detection of malignant follicular thyroid nodules.
  • Studies using paraffin-embedded tissue have indicated that high mobility group AT-hook 2 (HMGA2) overexpression is present in a high percentage of malignant thyroid neoplasms but not in benign thyroid neoplasms.
  • In the current study, the ability of HMGA2 overexpression analysis to preoperatively distinguish benign from malignant thyroid nodules by reverse transcriptase-polymerase chain reaction (RT-PCR) on suspicious cytologic smears was evaluated.
  • METHODS: Patients who underwent thyroid FNA and subsequent thyroid resection from 2001 through 2007 were identified.
  • A subset of these patients who had a cytologic diagnosis of "suspicious" underwent HMGA2 expression analysis.
  • With an HMGA2 overexpression change of 5.9-fold or greater compared with a thyroid tumor cell line as a positive cutoff, the test was found to have the following overall performance for detecting malignant nodules: sensitivity of 71%, specificity of 97%, positive predictive value of 94%, and negative predictive value of 84%.
  • CONCLUSIONS: HMGA2 mRNA expression analysis can be performed on cytologic smears and demonstrates a high specificity and positive predictive value and relatively high sensitivity and negative predictive value for detecting malignancy in "suspicious" thyroid aspirate specimens.
  • [MeSH-major] Gene Expression Regulation, Neoplastic. HMGA2 Protein / genetics. Thyroid Gland / metabolism. Thyroid Nodule / genetics
  • [MeSH-minor] Adenocarcinoma, Follicular / diagnosis. Adenocarcinoma, Follicular / genetics. Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / genetics. Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Child. Cytodiagnosis / methods. Diagnosis, Differential. Female. Goiter / diagnosis. Goiter / genetics. Humans. Male. Middle Aged. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reproducibility of Results. Reverse Transcriptase Polymerase Chain Reaction. Sensitivity and Specificity. Young Adult

  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] © 2010 American Cancer Society.
  • (PMID = 20597139.001).
  • [ISSN] 1934-662X
  • [Journal-full-title] Cancer cytopathology
  • [ISO-abbreviation] Cancer Cytopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / HMGA2 Protein; 0 / RNA, Messenger
  •  go-up   go-down


15. Mambo E, Chatterjee A, Xing M, Tallini G, Haugen BR, Yeung SC, Sukumar S, Sidransky D: Tumor-specific changes in mtDNA content in human cancer. Int J Cancer; 2005 Oct 10;116(6):920-4
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumor-specific changes in mtDNA content in human cancer.
  • We examined mtDNA content in 25 pairs of normal and tumor breast tissue samples, 37 papillary thyroid carcinoma (PTC), 21 benign thyroid neoplasms and in 20 paired normal and PTC samples.
  • Our results showed that mtDNA content was reduced in 80% of the breast tumors relative to their corresponding normal. mtDNA was increased in papillary thyroid carcinomas, however, when compared to the corresponding normal DNA taken from the same individual.
  • Our findings indicate that changes in mtDNA content during carcinogenesis may be regulated in a tumor specific manner.
  • Additionally, changes in mtDNA levels did not correlate with tumor grade and metastasis, suggesting that these alterations may occur in the early stages of tumorigenesis.
  • [MeSH-major] DNA, Mitochondrial / genetics. DNA, Neoplasm / genetics. Neoplasms / genetics
  • [MeSH-minor] Breast Neoplasms / genetics. Breast Neoplasms / pathology. Breast Neoplasms / surgery. Female. Humans. Polymerase Chain Reaction. Reference Values. Thyroid Diseases / genetics. Thyroid Diseases / pathology. Thyroid Neoplasms / genetics. Thyroid Neoplasms / pathology

  • COS Scholar Universe. author profiles.
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15856456.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 5U01CA084986-04; United States / NCI NIH HHS / CA / P01CA077664-07
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Mitochondrial; 0 / DNA, Neoplasm
  •  go-up   go-down


16. Evenson A, Mowschenson P, Wang H, Connolly J, Mendrinos S, Parangi S, Hasselgren PO: Hyalinizing trabecular adenoma--an uncommon thyroid tumor frequently misdiagnosed as papillary or medullary thyroid carcinoma. Am J Surg; 2007 Jun;193(6):707-12
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hyalinizing trabecular adenoma--an uncommon thyroid tumor frequently misdiagnosed as papillary or medullary thyroid carcinoma.
  • BACKGROUND: Hyalinizing trabecular adenoma (HTA) is an uncommon benign thyroid tumor that can present as a solitary thyroid nodule, a prominent nodule in a multinodular goiter, or as an incidental finding in a thyroidectomy specimen.
  • METHODS: Fine-needle aspiration biopsy was performed in 7 patients presenting with a solitary thyroid nodule (n = 4) or a multinodular goiter (n = 3).
  • CONCLUSIONS: Although HTA is a rare condition of the thyroid, the surgeon needs to be aware of this entity to be able to better discuss the pathological findings with the patient, particularly since some pathologists and endocrinologists believe that HTA may represent a malignant neoplasm of low metastatic potential.
  • [MeSH-major] Adenoma / pathology. Diagnostic Errors. Thyroid Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy, Fine-Needle. Carcinoma, Medullary / diagnosis. Carcinoma, Papillary / diagnosis. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies. Thyroidectomy

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17512281.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


17. Wiseman SM, Melck A, Masoudi H, Ghaidi F, Goldstein L, Gown A, Jones SJ, Griffith OL: Molecular phenotyping of thyroid tumors identifies a marker panel for differentiated thyroid cancer diagnosis. Ann Surg Oncol; 2008 Oct;15(10):2811-26
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular phenotyping of thyroid tumors identifies a marker panel for differentiated thyroid cancer diagnosis.
  • The objective of this work was to evaluate the molecular phenotype of differentiated thyroid cancer (DTC) and benign thyroid lesions to identify molecular markers that allow for accurate thyroid cancer diagnosis.
  • METHODS: Tissue microarrays consisting of 100 benign and 105 malignant thyroid lesions, plus 24 lymph node samples, were stained for a panel of 57 molecular markers.
  • Significant associations between marker staining and tumor pathology (DTC versus benign) were determined using contingency table and Mann-Whitney U (MU) tests.
  • RESULTS: Of the 57 diagnostic markers evaluated 35 (61%) were significantly associated with a DTC diagnosis after multiple testing correction.
  • Of these, in DTC compared with benign thyroid tumors, 8 markers were downregulated and 27 upregulated.
  • The most significant markers for DTC diagnosis were: Galectin-3, Cytokeratin 19, Vascular Endothelial Growth Factor, Androgen Receptor, p16, Aurora-A, and HBME-1.
  • Using the entire molecular marker panel, a Random Forests algorithm was able to classify tumors as DTC or benign with an estimated sensitivity of 87.9%, specificity of 94.0%, and an accuracy of 91.0%.
  • CONCLUSION: Evaluation of the DTC and benign thyroid tumor molecular phenotype has allowed for identification of a marker panel, composed of both established and novel markers, useful for thyroid cancer diagnosis.
  • These results suggest that further study of the molecular profile of thyroid tumors is warranted, and a diagnostic molecular marker panel may potentially improve patient selection for thyroid surgery.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma, Follicular / diagnosis. Adenocarcinoma, Follicular / metabolism. Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / metabolism. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / metabolism. Cell Differentiation. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Phenotype. Prognosis. Tissue Array Analysis

  • Genetic Alliance. consumer health - Thyroid Cancer.
  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • COS Scholar Universe. author profiles.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18612701.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


18. Rahbari R, Sansano IG, Elaraj DM, Duh QY, Clark OH, Kebebew E: Prior head and neck radiation exposure is not a contraindication to minimally invasive parathyroidectomy. J Am Coll Surg; 2010 Jun;210(6):942-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Most patients with primary hyperparathyroidism can have a minimally invasive parathyroidectomy based on localization studies showing single-gland disease.
  • In patients with a history of head and neck irradiation, due to the increased risk of multigland disease and risk of concurrent thyroid cancer, minimally invasive parathyroidectomy is considered by some to be a contraindication.
  • There was no significant difference in concurrent benign thyroid neoplasm, thyroid cancer, and type of parathyroid disease (single vs multigland) in the 2 groups.
  • CONCLUSIONS: Head and neck irradiation should not be a contraindication for minimally invasive parathyroidectomy in patients with primary hyperparathyroidism in the setting of preoperative localization studies showing single-gland disease and no concurrent thyroid neoplasm.
  • [MeSH-major] Head and Neck Neoplasms / radiotherapy. Hyperparathyroidism, Primary / surgery. Parathyroidectomy. Radiotherapy. Thyroid Neoplasms / radiotherapy

  • MedlinePlus Health Information. consumer health - Head and Neck Cancer.
  • MedlinePlus Health Information. consumer health - Radiation Therapy.
  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Published by Elsevier Inc.
  • (PMID = 20510803.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


19. Camargo RY, Tomimori EK: [Usefulness of ultrasound in the diagnosis and management of well-differentiated thyroid carcinoma]. Arq Bras Endocrinol Metabol; 2007 Jul;51(5):783-92
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Usefulness of ultrasound in the diagnosis and management of well-differentiated thyroid carcinoma].
  • [Transliterated title] Uso da ultra-sonografia no diagnóstico e seguimento do carcinoma bem diferenciado da tireóide.
  • Thyroid nodules are found in the vast majority of the population, but only 5 to 10% are malignant.
  • Ultrasonography of the thyroid, by virtue of being a straightforward, non-invasive method presenting strong correlation with macroscopic aspects of the thyroid gland, is being increasingly used to identify nodules that present a higher risk of malignancy.
  • Conversely, nodules presenting benign ultrasonographic characteristics such as hyperechogenicity and a mixed sponge-like aspect, and a concordant cytology, have a negative predictive value of 96.6%.
  • It is, thus, important to examine all nodular lesions and to identify suspicious lesions that need biopsy, especially in multinodular glands.
  • Ultrasonography is also highly sensitive in the identification of suspicious cervical lymph nodes during the follow-up of patients with thyroid carcinoma, even when PCI is negative and serum thyroglobulin (Tg) levels are undetectable.
  • Tg measurement in the needle wash-out content is recommended as this has proven to be more sensitive than cytology in the diagnosis of cervical metastasis, especially where there is liquid content, and it is not affected by the presence of anti-Tg antibodies.
  • [MeSH-major] Adenocarcinoma, Follicular / ultrasonography. Carcinoma, Papillary / ultrasonography. Thyroid Neoplasms / ultrasonography
  • [MeSH-minor] Biopsy, Fine-Needle / methods. Calcinosis / ultrasonography. Humans. Neoplasm Staging / methods. Predictive Value of Tests. Thyroglobulin / blood. Thyroid Nodule / pathology. Thyroid Nodule / ultrasonography. Ultrasonography, Doppler, Color. Whole Body Imaging

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • Hazardous Substances Data Bank. THYROGLOBULIN .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17891242.001).
  • [ISSN] 0004-2730
  • [Journal-full-title] Arquivos brasileiros de endocrinologia e metabologia
  • [ISO-abbreviation] Arq Bras Endocrinol Metabol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Brazil
  • [Chemical-registry-number] 9010-34-8 / Thyroglobulin
  • [Number-of-references] 50
  •  go-up   go-down


20. Kameyama K, Ito K, Takami H: [Pathology of benign thyroid tumor]. Nihon Rinsho; 2007 Nov;65(11):1973-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pathology of benign thyroid tumor].
  • True benign neoplasm of the thyroid gland is only follicular adenoma, which is a tumor derived from follicular cells.
  • The architectural pattern of follicular adenoma varies from trabecular to macrofollicular, and in most instances more than one architectural pattern is observed in one tumor.
  • Adenomatous goiter, a hyperplastic lesion of follicles, is the most common tumorous lesion of thyroid gland.
  • The gland is distorted with a nodular surface.
  • Mature or immature teratoma is also observed in the thyroid gland.
  • [MeSH-major] Adenoma / pathology. Thyroid Gland / pathology. Thyroid Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18018557.001).
  • [ISSN] 0047-1852
  • [Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine
  • [ISO-abbreviation] Nippon Rinsho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 2
  •  go-up   go-down


21. Lee SM, Kwak KH: Risk factors and a predictive model for thyroid cancer in Korean women. Cancer Nurs; 2010 Jul-Aug;33(4):310-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Risk factors and a predictive model for thyroid cancer in Korean women.
  • BACKGROUND: Thyroid cancer incidence in Korean women has increased radically and is the highest in all cancer types.
  • OBJECTIVE: The aim of the study was to determine the risk factors for thyroid cancer and to develop a predictive model based on these risk factors.
  • To construct a predictive model, the participants selected were 260 female outpatients diagnosed with malignant neoplasm of thyroid gland who had undergone thyroid removal surgery.
  • Nine variables, including occupation, live(d) in coastal region, family history of thyroid cancer, history of benign thyroid tumor, menopause status and weight gain, number of full-term deliveries, abortion, exercise intensity, and stress, remained as statistically significant risk factors in the stepwise regression model.
  • CONCLUSION: The predictive power of the model was relatively good, so it can be used to identify individuals at high risk for thyroid cancer.
  • Thus, it will be possible to detect thyroid cancer in its earliest stage, diminish mortality, and improve quality of life.
  • [MeSH-major] Logistic Models. Risk Assessment / organization & administration. Thyroid Neoplasms / epidemiology. Thyroid Neoplasms / etiology. Women's Health

  • Genetic Alliance. consumer health - Thyroid Cancer.
  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • MedlinePlus Health Information. consumer health - Women's Health.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20495449.001).
  • [ISSN] 1538-9804
  • [Journal-full-title] Cancer nursing
  • [ISO-abbreviation] Cancer Nurs
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] United States
  •  go-up   go-down


22. Owston MA, Ramsay EC, Rotstein DS: Neoplasia in felids at the Knoxville Zoological Gardens, 1979-2003. J Zoo Wildl Med; 2008 Dec;39(4):608-13
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neoplasia in felids at the Knoxville Zoological Gardens, 1979-2003.
  • A review of medical records and necropsy reports from 1979-2003 found 40 neoplasms in 26 zoo felids, including five lions (Panthera leo, two males and three females), three leopards (Panthera pardus, two males and one female), one jaguar (Panthera onca, female), 11 tigers (Panthera tigris, three males and eight females), two snow leopards (Panthera uncia, one male and one female), two cougars (Felis concolor, one male and one female), one bobcat (Felis rufus, male), and one cheetah (Acinonyx jubatus, female).
  • Neoplasia rate at necropsy was 51% (24/47), and overall incidence of felid neoplasia during the study period was 25% (26/103).
  • Neoplasia was identified as the cause of death or reason for euthanasia in 28% (13/47) of those necropsied.
  • Neoplasms were observed in the integumentary-mammary (n=11), endocrine (n=10), reproductive (n=8), hematopoietic-lymphoreticular (n=5), digestive (n=3), and hepatobiliary (n=2) systems.
  • One neoplasm was unclassified by system.
  • Multiple neoplasms were observed in 11 animals.
  • Both benign and malignant neoplasms were observed in all systems except for the hematopoietic-lymphoreticular systems where all processes were malignant.
  • Of the endocrine neoplasms, those involving the thyroid and parathyroid glands predominated (n=8) over other endocrine organs and included adenomas and carcinomas.
  • In the integumentary system, 63% (7/11) of neoplasms involved the mammary gland, with mammary carcinoma representing 83% (6/7) of the neoplasms.
  • The rates of neoplasia at this institution, during the given time period, appears to be greater than rates found in the one other published survey of captive felids.
  • [MeSH-major] Felidae. Neoplasms / veterinary

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19110704.001).
  • [ISSN] 1042-7260
  • [Journal-full-title] Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians
  • [ISO-abbreviation] J. Zoo Wildl. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


23. Nio Y, Iguchi C, Itakura M, Toga T, Hashimoto K, Koike M, Omori H, Sato Y, Endo S: High incidence of synchronous or metachronous breast cancer in patients with malignant and benign thyroid tumor or tumor-like disorders. Anticancer Res; 2009 May;29(5):1607-10
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High incidence of synchronous or metachronous breast cancer in patients with malignant and benign thyroid tumor or tumor-like disorders.
  • BACKGROUND: Although many reports indicated an association between thyroid diseases and breast cancer, such an association still remains controversial.
  • The present study was aimed to clarify the association of thyroid diseases with the breast cancer incidence.
  • In the patients with benign and malignant thyroid tumor or tumor-like disorders, the incidence of other malignancies was surveyed, and the frequency of thyroid cancer in patients with breast cancer was also surveyed.
  • PATIENTS AND METHODS: Between 1982 and 2005, a total of 201 female patients received surgery for tumor or tumor-like disorders, including 65 carcinoma, 68 adenoma, 61 adenomatous goiter and 7 chronic thyroiditis cases.
  • RESULTS: The overall incidence rate of breast cancer was 16.4% (33/201) in the patients, who received thyroid surgeries and was much higher than other malignancies: 2.0% gastric cancer, 1.0% uterine and colorectal cancer.
  • The incidence rate of breast cancer in each disease was 13.8% for thyroid cancer, 16.2% for adenoma and 21.3% for adenomatous goiter, but no incidence for chronic thyroiditis.
  • On the other hand, in the patients with breast cancer during the same period in our department, the frequency of thyroid cancer was only 2.1% (7/340).
  • CONCLUSION: It appears that thyroid cancer, adenoma and adenomatous goiter were associated with the risk of breast cancer, but chronic thyroiditis was not related.
  • [MeSH-major] Breast Neoplasms / epidemiology. Neoplasms, Second Primary / complications. Thyroid Neoplasms / complications


24. Chang T, Husain AN, Colby T, Taxy JB, Welch WR, Cheung OY, Early A, Travis W, Krausz T: Pneumocytic adenomyoepithelioma: a distinctive lung tumor with epithelial, myoepithelial, and pneumocytic differentiation. Am J Surg Pathol; 2007 Apr;31(4):562-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pneumocytic adenomyoepithelioma: a distinctive lung tumor with epithelial, myoepithelial, and pneumocytic differentiation.
  • Pulmonary tumors with epithelial and myoepithelial differentiation are rare, thought to be of bronchial minor salivary gland origin and classified similarly to salivary gland neoplasms.
  • Some glands were filled with colloidlike secretion and had an inner, cuboidal epithelial cell layer (pankeratin, epithelial membrane antigen, and thyroid transcription factor-1 positive), surrounded by an outer layer of myoepithelial cells merging with foci of spindled myoepithelial cells (high molecular weight keratin, S100, smooth muscle actin, calponin, caldesmon, and p63 positive).
  • There were also some glands lined by a single layer of plump cells that were positive for surfactant protein-A in addition to the other epithelial cell markers.
  • The biologic behavior to date has been benign.
  • This is the first reported series of a distinctive lung tumor with epithelial, myoepithelial, and pneumocytic differentiation that differs histologically from all previously recognized pulmonary salivary gland-type and pneumocytic tumors.
  • It is a unique benign appearing neoplasm for which the designation pneumocytic adenomyoepithelioma is suggested.
  • [MeSH-major] Lung Neoplasms / pathology. Myoepithelioma / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Female. Humans. Microscopy, Electron, Transmission. Middle Aged. Treatment Outcome

  • MedlinePlus Health Information. consumer health - Lung Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17414103.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


25. Kebebew E, Peng M, Reiff E, Duh QY, Clark OH, McMillan A: Diagnostic and prognostic value of cell-cycle regulatory genes in malignant thyroid neoplasms. World J Surg; 2006 May;30(5):767-74
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic and prognostic value of cell-cycle regulatory genes in malignant thyroid neoplasms.
  • BACKGROUND: Approximately 30% of patients with thyroid nodules have indeterminate or suspicious fine-needle aspiration (FNA) biopsy results.
  • We hypothesized that genes that regulate cell-cycle progression would be differentially expressed in malignant versus benign thyroid nodules and could serve as diagnostic markers and markers of disease aggressiveness.
  • METHODS: We used a cDNA array with 96 cell-cycle regulatory genes to identify differentially expressed genes in pooled benign versus malignant thyroid neoplasms.
  • Genes up- or down-regulated by more than 2-fold in malignant thyroid neoplasms were further evaluated by real-time quantitative polymerase chain reaction (PCR) in 95 patients with hyperplastic nodules (n = 19), follicular adenoma (n = 19), follicular thyroid cancer (n = 19), the follicular variant of papillary thyroid cancer (n = 19), and papillary thyroid cancer (n = 19).
  • RESULTS: cDNA array analysis showed that cyclin B1, MCM5, MCM7, RAD9, ubiquitin C, CDK6, SKP2, and APAF1 were up-regulated in malignant thyroid neoplasms.
  • Real-time quantitative PCR showed that MCM5, MCM7, and RAD9 mRNA expression were significantly higher in malignant than in benign thyroid neoplasms (< or = 0.0012).
  • The level of MCM7 mRNA expression was higher in T4 than in T1, T2, and T3 differentiated thyroid cancers (P < 0.0127).
  • CONCLUSIONS: MCM5, MCM7, and RAD9 are overexpressed in malignant thyroid neoplasms of follicular cell origin.
  • These genes may be useful markers of malignant thyroid neoplasms as an adjunct to FNA biopsy.
  • MCM7 mRNA expression is higher in locally invasive differentiated thyroid cancer.
  • [MeSH-major] Adenocarcinoma, Follicular / genetics. Biomarkers, Tumor / genetics. Cell Cycle Proteins / genetics. Thyroid Neoplasms / genetics
  • [MeSH-minor] Biopsy, Fine-Needle. DNA-Binding Proteins / biosynthesis. DNA-Binding Proteins / genetics. Gene Expression. Humans. Minichromosome Maintenance Complex Component 7. Neoplasm Invasiveness. Nuclear Proteins / biosynthesis. Nuclear Proteins / genetics. Oligonucleotide Array Sequence Analysis. Polymerase Chain Reaction. Prognosis. Thyroidectomy

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • COS Scholar Universe. author profiles.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Oncogene. 1999 Apr 8;18(14):2299-309 [10327050.001]
  • [Cites] Surg Clin North Am. 2004 Jun;84(3):907-19 [15145242.001]
  • [Cites] Ann Surg. 2004 Sep;240(3):425-36; discussion 436-7 [15319714.001]
  • [Cites] Lancet Oncol. 2002 Sep;3(9):522 [12217780.001]
  • [Cites] Clin Cancer Res. 1999 Aug;5(8):2121-32 [10473096.001]
  • [Cites] Br J Cancer. 2003 Jan 27;88(2):257-62 [12610511.001]
  • [Cites] Cancer. 2005 Jan 1;103(1):126-32 [15558813.001]
  • [Cites] J Natl Cancer Inst. 2002 Jul 17;94(14):1071-9 [12122098.001]
  • [Cites] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2002 Nov;20(2):77-116 [12515671.001]
  • [Cites] Diagn Cytopathol. 2002 Jan;26(1):41-4 [11782086.001]
  • [Cites] Cancer. 2000 Dec 25;90(6):335-41 [11156516.001]
  • [Cites] J Clin Pathol. 2004 Oct;57(10):1057-62 [15452160.001]
  • [Cites] Cancer. 2005 Apr 1;103(7):1330-5 [15739211.001]
  • [Cites] Oncogene. 2004 Apr 1;23(14):2484-98 [14676830.001]
  • [Cites] Am Surg. 1998 Jul;64(7):674-8; discussion 678-9 [9655281.001]
  • [Cites] J Clin Pathol. 2005 May;58(5):525-34 [15858126.001]
  • [Cites] Cancer Res. 2002 Feb 15;62(4):1123-8 [11861392.001]
  • [Cites] Br J Cancer. 2004 Aug 16;91(4):714-9 [15266314.001]
  • [Cites] World J Surg. 2005 Mar;29(3):317-24 [15706435.001]
  • [Cites] J Clin Endocrinol Metab. 1999 Mar;84(3):951-5 [10084577.001]
  • [Cites] Gut. 2002 Mar;50(3):373-7 [11839717.001]
  • [Cites] Thyroid. 2004 Apr;14(4):287-93 [15142362.001]
  • [Cites] Ann Intern Med. 1993 Feb 15;118(4):282-9 [8420446.001]
  • [Cites] Annu Rev Biochem. 2002;71:333-74 [12045100.001]
  • [Cites] Neoplasia. 2004 Sep-Oct;6(5):611-22 [15548371.001]
  • [Cites] FASEB J. 1997 Jan;11(1):68-76 [9034168.001]
  • [Cites] Gut. 2002 Mar;50(3):290-1 [11839701.001]
  • [Cites] Endocr Pathol. 2002 Winter;13(4):301-11 [12665648.001]
  • [Cites] Thyroid. 1998 Nov;8(11):981-7 [9848710.001]
  • [Cites] BJU Int. 2003 Nov;92(7):823-4 [14616479.001]
  • [Cites] J Clin Endocrinol Metab. 2005 Aug;90(8):4703-9 [15899946.001]
  • [Cites] FASEB J. 2004 Mar;18(3):560-1 [14715705.001]
  • [Cites] Cancer. 2004 Jul 1;101(1):3-27 [15221985.001]
  • [Cites] Lancet. 1999 Oct 30;354(9189):1524-5 [10551502.001]
  • [Cites] Mayo Clin Proc. 1993 Apr;68(4):343-8 [8455392.001]
  • [Cites] Clin Ter. 1999 Mar-Apr;150(2):135-41 [10396863.001]
  • [Cites] N Engl J Med. 1993 Feb 25;328(8):553-9 [8426623.001]
  • [Cites] Clin Lab Med. 1993 Sep;13(3):699-709 [8222583.001]
  • [Cites] Cancer Res. 2003 Dec 1;63(23):8173-80 [14678972.001]
  • (PMID = 16547620.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / DNA-Binding Proteins; 0 / MCM5 protein, human; 0 / Nuclear Proteins; 139691-42-2 / rad9 protein; EC 3.6.4.12 / MCM7 protein, human; EC 3.6.4.12 / Minichromosome Maintenance Complex Component 7
  •  go-up   go-down


26. Woźniak E, Klencki M, Popowicz B, Sporny S, Słowińska-Klencka D: The recurrent goitre unusually located near the hyoid bone. Endokrynol Pol; 2010 Sep-Oct;61(5):448-53
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Recurrent goitre is a significant clinical problem among patients who have been operated due to benign lesions.
  • The aim of this study was to analyze if this unusual localization of recurrence is related to any significant differences in the clinical course, and if it significantly increases the risk of thyroid neoplasm.
  • The analysis included the period from the operation to the lesion-revealing US, the lesion's volume, the presence of ultrasound features of malignancy, the volume of residual thyroid tissue in the thyroid bed, the changes in volumes of examined structures, and the outcomes of cytological examinations.
  • CONCLUSIONS: Focal lesions near the hyoid bone, revealed in patients operated previously for benign goitre, are not related to increased risk of thyroid neoplasm, and their enlargement does not imply their malignancy.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21049456.001).
  • [ISSN] 0423-104X
  • [Journal-full-title] Endokrynologia Polska
  • [ISO-abbreviation] Endokrynol Pol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
  •  go-up   go-down


27. Tomoda C, Takamura Y, Ito Y, Miya A, Miyauchi A: Transient vocal cord paralysis after fine-needle aspiration biopsy of thyroid tumor. Thyroid; 2006 Jul;16(7):697-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transient vocal cord paralysis after fine-needle aspiration biopsy of thyroid tumor.
  • OBJECTIVE: Complications of thyroid fine-needle aspiration biopsy (FNAB) are exceedingly rare.
  • Here we describe patients diagnosed as having transient vocal cord paralysis after FNAB of benign thyroid tumor.
  • DESIGN: Retrospective review of patients with concurrent diagnosis of vocal cord paralysis after FNAB.
  • These patients had solid and/or cystic lesion in the thyroid.
  • Cytologic findings were benign tumor.
  • CONCLUSION: Although the incidence of vocal cord paralysis in patients with thyroid tumor after FNAB is reported to be 0.036%, the true incidence is unknown because asymptomatic subjects are not screened.
  • [MeSH-major] Biopsy, Fine-Needle / adverse effects. Thyroid Neoplasms / pathology. Thyroid Nodule / pathology. Vocal Cord Paralysis / chemically induced. Vocal Cords / drug effects

  • Genetic Alliance. consumer health - paralysis.
  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16889495.001).
  • [ISSN] 1050-7256
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


28. Lieu D: Cytopathologist-performed ultrasound-guided fine-needle aspiration of parathyroid lesions. Diagn Cytopathol; 2010 May;38(5):327-32
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • As most cases are caused by parathyroid adenoma, there is a movement toward preoperative localization of the abnormal gland by ultrasound and/or Tc(99)-sestamibi scan and minimally invasive parathyroidectomy.
  • Nonpalpable thyroid nodules are common and cannot be differentiated from parathyroid lesions by imaging alone.
  • This study examines cytopathologist-performed ultrasound-guided fine-needle aspiration (UG-FNA) in diagnosis of parathyroid lesions.
  • Between January 1, 2007 and December 31, 2008, seven patients with PHPT or other parathyroid lesions with one or more sonographically-visible thyroid masses underwent cytopathologist-performed UG-FNA with immediate cytological evaluation (ICE).
  • Three parathyroid adenomas, two benign colloid nodules, one papillary carcinoma, three parathyroid cysts, and one thyroid cyst were diagnosed.
  • The nodules in three patients with parathyroid adenomas were identified as follicular lesion/neoplasm on ICE.
  • Two of these patients had a separate benign colloid nodule and one had a thyroid cyst diagnosed by UG-FNA.
  • The three patients with thyroid cysts identified by radiology were suspected of being parathyroid cysts on the basis of real-time sonographic features at the biopsy table.
  • Cytopathologist-performed UG-FNA can distinguish between parathyroid and thyroid nodules in patients with suspected parathyroid lesions.
  • [MeSH-major] Adenoma / pathology. Biopsy, Fine-Needle / methods. Parathyroid Glands / pathology. Parathyroid Glands / ultrasonography. Parathyroid Neoplasms / pathology. Parathyroid Neoplasms / ultrasonography. Thyroid Nodule / pathology. Thyroid Nodule / ultrasonography

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19845029.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


29. Xu F, Liu B, Chen XY, Zhou EX, Fan DF, Ma Y, Tang ZH: [Diagnosis and therapy of childhood thyroid carcinoma: clinical analysis of 12 cases]. Zhongguo Dang Dai Er Ke Za Zhi; 2009 Feb;11(2):120-3
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnosis and therapy of childhood thyroid carcinoma: clinical analysis of 12 cases].
  • OBJECTIVE: To explore the clinical characteristics, diagnosis and therapy of thyroid carcinoma in children.
  • METHODS: Clinical data of 12 children under the age of 14 years, diagnosed as thyroid carcinoma between August 1998 and August 2008, were reviewed.
  • RESULTS: A hard thyroid mass was observed in 10 out of 12 children with thyroid carcinoma, but only one out of 15 children with benign thyroid tumor (<0.05).
  • The rate of cervical lymph node metastasis in children with thyroid carcinoma was significantly higher than that in children with benign thyroid tumor (<0.05).
  • There was no significant difference in the final diagnostic rate of thyroid carcinoma between ultrasonography and CT scans (75% vs 83%; >0.05).
  • All of 12 cases were pathologically confirmed as differentiated thyroid carcinoma, including papillary carcinoma (7 cases), follicular carcinoma (3 cases) and papillary-follicular carcinoma (2 cases).
  • CONCLUSIONS: Childhood thyroid carcinoma is mostly differentiated and characterized by hard thyroid mass and cervical lymph node metastasis.
  • A combination of ultrasonography and CT is helpful to the diagnosis of childhood thyroid carcinoma.
  • The treatment outcome may be satisfactory by optimal therapy in children with thyroid carcinoma.
  • [MeSH-major] Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / surgery

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19222949.001).
  • [ISSN] 1008-8830
  • [Journal-full-title] Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
  • [ISO-abbreviation] Zhongguo Dang Dai Er Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
  •  go-up   go-down






Advertisement