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Items 1 to 34 of about 34
1. Goto T, Maeshima A, Oyamada Y, Kato R: Definitive diagnosis of multiple myeloma from rib specimens resected at thoracotomy in a patient with lung cancer. Interact Cardiovasc Thorac Surg; 2010 Jun;10(6):1051-3
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  • [Title] Definitive diagnosis of multiple myeloma from rib specimens resected at thoracotomy in a patient with lung cancer.
  • Serum immunoelectrophoresis detected IgG-lambda monoclonal protein; therefore, we suspected the coexistence of multiple myeloma, amyloidosis, benign macroglobulinemia, or benign monoclonal gammopathy.
  • Since the patient continued to expectorate large amounts of bloody sputum every day, and his anemia progressed, right upper lobectomy and lymph node dissection were performed on a semi-emergent basis without preoperative bone marrow examination.
  • The postoperative pathological diagnosis was SCC of the lung (p-T2N0M0, stage IB).
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Lung Neoplasms / surgery. Multiple Myeloma / diagnosis. Neoplasms, Multiple Primary. Ribs / pathology. Thoracotomy
  • [MeSH-minor] Biomarkers, Tumor / analysis. Humans. Immunohistochemistry. Lymph Node Excision. Male. Middle Aged. Neoplasm Staging. Tomography, X-Ray Computed


2. Bodner JC, Zitt M, Ott H, Wetscher GJ, Wykypiel H, Lucciarini P, Schmid T: Robotic-assisted thoracoscopic surgery (RATS) for benign and malignant esophageal tumors. Ann Thorac Surg; 2005 Oct;80(4):1202-6
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  • [Title] Robotic-assisted thoracoscopic surgery (RATS) for benign and malignant esophageal tumors.
  • The esophagus possesses attributes that are interesting for general thoracic robotic surgeons.
  • This comprised the dissection of the intrathoracic esophagus including lymph node dissection in four patients suffering from esophageal cancer and the extirpation of a benign lesion (one leiomyoma and one foregut cyst) in the remaining two patients.
  • The median overall operating time was 173 (160-190) minutes in the oncologic cases and 121 minutes in the benign cases, including the robotic act of 147 (135-160) minutes and 94 minutes, respectively.
  • One patient had to undergo a redo thoracoscopy because of a persistent lymph fistula.
  • One cancer patient died after 12 months due to tumor progression and another patient had to be stented due to local tumor recurrence 19 months postoperatively.
  • [MeSH-minor] Adenocarcinoma / surgery. Aged. Carcinoma, Squamous Cell / surgery. Esophageal Cyst / surgery. Female. Follow-Up Studies. Humans. Leiomyoma / surgery. Length of Stay. Male. Middle Aged. Neoplasm Recurrence, Local. Robotics / instrumentation. Robotics / methods. Treatment Outcome

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  • (PMID = 16181841.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Netherlands
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3. Ai Z, Zhang W, Luo W, Huang L, Pan Y: Expression of Pin1 mRNA in non-small-cell lung cancer patients. Asian Cardiovasc Thorac Ann; 2009 Apr;17(2):157-61
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  • Pin1 mRNA expression in blood samples from patients with lung cancer, controls with benign lung disease, and healthy subjects were determined by a real-time reverse transcriptase polymerase chain reaction.
  • Compared to those with benign lung disease and healthy controls, Pin1 mRNA was overexpressed in patients with non-small-cell lung cancer, and the levels correlated with lymph node-positive disease and tumor stage.
  • These findings suggest that Pin1 might be a useful tumor marker for cancer therapy.
  • [MeSH-major] Biomarkers, Tumor / genetics. Carcinoma, Non-Small-Cell Lung / genetics. Lung Neoplasms / genetics. Peptidylprolyl Isomerase / genetics. RNA, Messenger / blood
  • [MeSH-minor] Aged. Female. Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Humans. Ligation. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Pulmonary Artery / surgery. Pulmonary Surgical Procedures. Pulmonary Veins / surgery. Time Factors. Treatment Outcome. Up-Regulation

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  • (PMID = 19592546.001).
  • [ISSN] 1816-5370
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] Singapore
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / NIMA-interacting peptidylprolyl isomerase; 0 / RNA, Messenger; EC 5.2.1.8 / Peptidylprolyl Isomerase
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4. Keylock JB, Galvin JR, Franks TJ: Sclerosing hemangioma of the lung. Arch Pathol Lab Med; 2009 May;133(5):820-5
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  • We present a brief review of sclerosing hemangioma, an uncommon but histologically distinctive neoplasm of the lung.
  • Sclerosing hemangiomas typically present as asymptomatic, peripheral, solitary, well-circumscribed lesions in women with a mean age at diagnosis in the fifth decade.
  • Rare cases are reported to have regional lymph node metastases; however, metastases do not appear to affect long-term survival.
  • Sclerosing hemangioma of the lung is generally considered to be a benign lesion, and surgical excision is curative without the need for additional treatment.
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Carcinoma / diagnosis. Carcinoma / secondary. Diagnosis, Differential. Female. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Male. Prognosis. Radiography, Thoracic. Respiratory Mucosa / metabolism. Respiratory Mucosa / pathology. Tomography, X-Ray Computed

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  • (PMID = 19415961.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 29
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5. Liu XY, Chen G, Wang Z, Liu FY: Clinical significance of detecting mucin 1 mRNA in diagnosing occult lymph node micrometastasis in esophageal cancer patients. Ai Zheng; 2007 Feb;26(2):194-9
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  • [Title] Clinical significance of detecting mucin 1 mRNA in diagnosing occult lymph node micrometastasis in esophageal cancer patients.
  • BACKGROUND & OBJECTIVE: Early postoperative relapse in esophageal cancer might be related to occult lymph node micrometastasis that could not be detected by routine histopathologic examination.
  • This study was to investigate the clinical significance of detecting Mucin 1 (MUC1) mRNA in diagnosing occult lymph node micrometastasis in esophageal cancer patients, and to evaluate its prognostic significance.
  • METHODS: The expression of MUC1 mRNA in 366 regional lymph nodes from 63 esophageal squamous cell cancer (ESCC) patients without histopathologically confirmed invasion (pN0), 30 paraesophageal lymph nodes from patients with benign esophageal diseases, and 15 lymph nodes and 15 tumor tissues from ESCC patients with histopathologically proved metastasis (pN1) were detected by reverse transcription-polymerase chain reaction (RT-PCR) to determine micrometastasis.
  • RESULTS: Specificity of genetic diagnosis was 100.0% (30/30) for occult lymph node micrometastasis, and 90.0% (27/30) for lymph node micrometastasis.
  • MUC1 mRNA was identified in 30 (8.2%) lymph nodes from 22 (34.9%) patients.
  • Occult lymph node micrometastasis was diagnosed in these patients.
  • The 3-year survival rate was significantly lower in the patients with lymph node micrometastasis than in the patients without lymph node micrometastasis (54.5% vs. 80.5%, P<0.01).
  • In Logistic regression analysis, lymph node micrometastasis (P<0.05, odds ratio=3.71) and T3 tumor (P<0.05, odds ratio=7.17) were independent prognostic factors.
  • CONCLUSIONS: It is helpful to diagnose occult lymph node micrometastasis by detecting the expression of MUC1 mRNA in lymph nodes of pN0 ESCC patients.
  • Lymph node micrometastasis may predict poor prognosis of the patients after radial operation.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Esophageal Neoplasms / metabolism. Lymph Nodes / metabolism. Lymphatic Metastasis / diagnosis. Mucin-1 / biosynthesis
  • [MeSH-minor] Aged. Base Sequence. DNA, Complementary / genetics. DNA, Neoplasm / genetics. Female. Follow-Up Studies. Humans. Male. Middle Aged. Molecular Sequence Data. Neoplasm Staging. Prognosis. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17298752.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / DNA, Neoplasm; 0 / Mucin-1; 0 / RNA, Messenger
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6. Cerfolio RJ, Bryant AS: Ratio of the maximum standardized uptake value on FDG-PET of the mediastinal (N2) lymph nodes to the primary tumor may be a universal predictor of nodal malignancy in patients with nonsmall-cell lung cancer. Ann Thorac Surg; 2007 May;83(5):1826-9; discussion 1829-30
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  • [Title] Ratio of the maximum standardized uptake value on FDG-PET of the mediastinal (N2) lymph nodes to the primary tumor may be a universal predictor of nodal malignancy in patients with nonsmall-cell lung cancer.
  • BACKGROUND: The maximum standardized uptake value (maxSUV) on F-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) scan of mediastinal (N2) lymph nodes may predict pathology in patients with nonsmall-cell lung cancer.
  • Thus, we evaluated the ratio of the maxSUV of the lymph node to the primary tumor at different centers to determine whether it was a universal predictor of lymph node malignancy.
  • Patients with nonsmall-cell lung cancer, a dedicated FDG-PET with the maxSUV of the primary lung tumor and FDG-avid mediastinal (N2) nodes reported (before therapy), and who underwent lymph node removal were eligible.
  • RESULTS: There were 239 patients with 335 FDG-PET-positive N2 nodes at 14 different PET centers.
  • The median ratio of the maxSUV of the lymph node to the maxSUV of the primary tumor of the pathologically proven malignant nodes was 0.58 (range, 0.32 to 1.61).
  • Benign nodes had a median ratio of 0.40 (range, 0.21 to 1.10, p = 0.02).
  • CONCLUSIONS: The ratio of the maxSUV of the mediastinal (N2) lymph node to the maxSUV of the primary tumor in patients with nonsmall-cell lung cancer predicts mediastinal nodal pathology across different PET centers.
  • When the ratio is 0.56 or greater, there is a 94% chance that the node is malignant.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Lymph Nodes / radionuclide imaging. Lymphatic Metastasis. Male. Mediastinum. Middle Aged. Neoplasm Staging. Predictive Value of Tests

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  • (PMID = 17462407.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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7. Li BJ, Huang XP, Wei WD, Wang JY, Su XD, Zhang X, Hong WS, Tang J, Zhang LJ, Long H, Yang MT, Rong TH: [Expression and clinical significance of cytokeratin 19 in bone marrow of patients with breast cancer]. Ai Zheng; 2005 Jun;24(6):735-9
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  • METHODS: Expression of CK19 mRNA in bone marrows of 65 breast cancer patients, 15 benign breast disease patients, and 8 healthy volunteers was detected by reverse transcription-polymerase chain reaction (RT-PCR).
  • RESULTS: Positive rate of CK19 mRNA was 33.8% in the 65 breast cancer patients, and 0 in both benign breast disease patients and healthy volunteers.
  • Expression of CK19 mRNA was positively correlated with tumor size and clinical stage (P < 0.05), but was not related to age and lymph node status (P > 0.05).
  • [MeSH-minor] Adult. Aged. Breast Neoplasms, Male / metabolism. Breast Neoplasms, Male / pathology. Carcinoembryonic Antigen / blood. Female. Fibroadenoma / blood. Fibroadenoma / metabolism. Fibroadenoma / pathology. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. RNA, Messenger / biosynthesis. RNA, Messenger / genetics

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  • (PMID = 15946491.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Keratin-19; 0 / RNA, Messenger
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8. Mao YS, He J, Zheng R, Lin L, Liu L, Cheng Z: [The role of (18)F-FDG DHC SPECT-CT in the diagnosis and staging for lung cancer]. Zhonghua Zhong Liu Za Zhi; 2008 Dec;30(12):933-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The role of (18)F-FDG DHC SPECT-CT in the diagnosis and staging for lung cancer].
  • OBJECTIVE: To investigate and compare the clinical significance of (18)F-FDG single-photon emission computed tomography and computed tomography (SPECT-CT) in the diagnosis and staging of lung cancer.
  • Fifty-seven of the 71 patients had definite pathological or cytological diagnosis, consisting of 52 malignant lung tumors and 5 benign pulmonary nodules.
  • RESULTS: Taking the pathological diagnosis as gold standard, the sensitivity, specificity and accuracy of diagnosing pulmonary lesions suspected as lung cancer were 84.6% (44/52), 80.0% (4/5), 84.2% (48/57) for conventional CT and 92.3% (48/52), 80.0% (4/5), 91.2% (52/57) for SPECT-CT, respectively.
  • The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of staging hilar and mediastinal lymph nodes were 76.9%, 79.2%, 78.4%, 66.6%, 86.4% for conventional CT versus 61.5%, 75.0%, 70.3%, 57.1%, 78.3% for SPECT-CT (P > 0.05), respectively.
  • It can be used as a non-invasive supplementary tool for differential diagnosis between malignant and benign pulmonary lesions and in diagnosis of lymph node > 1 cm in diameter.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Fluorodeoxyglucose F18. Lung Neoplasms / diagnosis. Neoplasm Staging. Tomography, Emission-Computed, Single-Photon / methods
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / radiography. Adenocarcinoma / radionuclide imaging. Adult. Aged. Aged, 80 and over. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Radiopharmaceuticals. Small Cell Lung Carcinoma / diagnosis. Small Cell Lung Carcinoma / pathology. Small Cell Lung Carcinoma / radiography. Small Cell Lung Carcinoma / radionuclide imaging. Tomography, X-Ray Computed

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  • (PMID = 19173997.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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9. Paci M, Cavazza A, Annessi V, Ricchetti T, Rapicetta C, Sgarbi G: Cystic fibrohistiocytic tumor of the lung presenting as a solitary lesion. Rare Tumors; 2010;2(1):e14
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  • [Title] Cystic fibrohistiocytic tumor of the lung presenting as a solitary lesion.
  • Cystic fibrohistiocytic tumor of the lung is a rare neoplasm.
  • In many cases it represents a metastasis from a benign or low-grade fibrohistiocytic tumor of the skin, but occasionally it may be primary.
  • Microscopy of the apical segmentectomy showed a cystic fibrohistiocytic tumor, whereas the nodule of the lower lobe was an intraparenchymal lymph node.
  • The patient is alive with no tumor recurrence.
  • The differential diagnosis includes Langerhans cell histiocytosis, lymphangioleiomyomatosis, pleuropulmonary blastoma, and metastatic endometrial stromal sarcoma.

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  • (PMID = 21139943.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994490
  • [Keywords] NOTNLM ; cystic fibrohistiocytic tumor / lung neoplasms / mesenchymal cystic hamartoma / mesenchymal tumors / metastases / pneumothorax
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10. Kozlowski M, Kowalczuk O, Milewski R, Chyczewski L, Niklinski J, Laudański J: Serum vascular endothelial growth factors C and D in patients with oesophageal cancer. Eur J Cardiothorac Surg; 2010 Sep;38(3):260-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Lymph node metastasis is a characteristic of malignant cancers and is observed more frequently in oesophageal cancer than in other digestive tract cancers, making it one of the most important prognostic factors.
  • Vascular endothelial growth factors C (VEGF-C) and D (VEGF-D) are important lymphangiogenic factors in human cancers and lymphangiogenesis is associated with lymph node metastasis.
  • METHODS: Serum VEGF-C and sVEGF-D were measured by enzyme-linked immunoadsorbent assay (ELISA) on 149 patients with oesophageal cancer, 29 patients with benign oesophageal diseases and 30 healthy controls.
  • RESULTS: Serum VEGF-C and sVEGF-D levels were significantly higher in patients with oesophageal carcinoma than in the control group (p<0.001 and p=0.001, respectively) or in the benign oesophageal diseases group (p=0.04 and p=0.03, respectively).
  • Subgroup analysis showed that lymph node metastasis (p=0.001), stage (p=0.001), tumour depth (p=0.006), resectability (p=0.002), tumour size (p=0.01), distant metastases (p=0.01) and histological grading (p=0.04) were correlated with an elevated level of sVEGF-C.
  • Elevated levels of sVEGF-D were associated with tumour depth (p=0.002), stage (p=0.01) and lymph node metastasis (p=0.02).
  • On univariate regression analysis, tumour size, tumour depth, stage, lymph node metastases, distant metastases, resectability and sVEGF-C were found to be significant prognostic factors.
  • CONCLUSIONS: These results suggest that pre-treatment levels of sVEGF-C and sVEGF-D reflect lymph node metastases and advanced stage of oesophageal cancer.
  • [MeSH-major] Biomarkers, Tumor / blood. Esophageal Neoplasms / diagnosis. Vascular Endothelial Growth Factor C / blood. Vascular Endothelial Growth Factor D / blood
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Diagnosis, Differential. Epidemiologic Methods. Esophageal Diseases / diagnosis. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Proteins / metabolism. Neoplasm Staging. Prognosis. Treatment Outcome

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  • [Copyright] Copyright 2010. Published by Elsevier B.V.
  • (PMID = 20226684.001).
  • [ISSN] 1873-734X
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Vascular Endothelial Growth Factor C; 0 / Vascular Endothelial Growth Factor D
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11. Zhao J, Yang CL, Zhao SY: [Expression of SKP2 protein in lung carcinoma and its implication for prognosis]. Zhonghua Zhong Liu Za Zhi; 2007 Apr;29(4):289-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: The expression of SKP2 protein was detected in 89 NSCLC, 13 SCLC, 5 benign lung neoplasms, 5 normal bronchus and lung tissues by tissue chip and immunohistochemical techniques.
  • RESULTS: The positive rate of SKP2 staining was (23.52 +/-13.57)% in NSCLC tissues and (53.85 +/- 12.26)% in SCLC tissues, significantly higher than (2.91 +/- 1.27)% in benign lung neoplasms and normal bronchus and lung tissues.
  • Its expression was highest in SCLC tissues and lowest in benign lung tissues, with a significant difference between them (P <0.01).
  • The expressive level of SKP2 protein in lung carcinoma tissues was closely related to cell differentiation and lymph node metastasis, but not to age, sex, smoking history, tumor site and size, and TNM staging, etc.
  • CONCLUSION: The positive expression of SKP2 protein is higher in lung carcinoma than in benign or normal lung tissues, in particular, much higher in SCLC tissue.
  • [MeSH-minor] Adolescent. Adult. Aged. Bronchi / chemistry. Bronchi / pathology. Female. Humans. Immunohistochemistry. Lung / chemistry. Lung / pathology. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Prognosis. Survival Analysis

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  • (PMID = 17760257.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / S-Phase Kinase-Associated Proteins
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12. Gedik GK, Kara PO, Kara T, Sari O, Kara F: Evaluation of FDG uptake in pulmonary hila with FDG PET/CT and contrast-enhanced CT in patients with thoracic and non-thoracic tumors. Ann Nucl Med; 2010 Oct;24(8):593-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of FDG uptake in pulmonary hila with FDG PET/CT and contrast-enhanced CT in patients with thoracic and non-thoracic tumors.
  • Our objective was to evaluate the features of FDG uptake in lung hilus associated with benign or malignant etiology in patients with thoracic and non-thoracic tumors.
  • In 30 of 71 (42.3%) hilar regions, FDG uptake was considered to be physiological because no lymph node was observed on CECT.
  • In 19 of 71 (26.8%), FDG uptake was secondary to benign lymph nodes and in 22 (30.9%) to malignant lymph nodes.
  • Significant differences were observed between benign and malignant lymph nodes for SUVhilus and SUVhilus/SUVliver ratio.
  • For SUVhilus/SUVliver ratio, sensitivity and specificity to detect malignant lymph nodes were 77.6 and 77.3% (AUC: 0.885), respectively, at a cut-off value of 1.75.
  • [MeSH-major] Contrast Media. Fluorodeoxyglucose F18 / metabolism. Lung / metabolism. Positron-Emission Tomography. Thoracic Neoplasms / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biological Transport. Child. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Retrospective Studies. Young Adult

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  • (PMID = 20665251.001).
  • [ISSN] 1864-6433
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Contrast Media; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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13. Eloubeidi MA, Cerfolio RJ, Chen VK, Desmond R, Syed S, Ojha B: Endoscopic ultrasound-guided fine needle aspiration of mediastinal lymph node in patients with suspected lung cancer after positron emission tomography and computed tomography scans. Ann Thorac Surg; 2005 Jan;79(1):263-8
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  • [Title] Endoscopic ultrasound-guided fine needle aspiration of mediastinal lymph node in patients with suspected lung cancer after positron emission tomography and computed tomography scans.
  • Positron emission and computed tomography (CT) scans can identify suspicious lymph nodes that require biopsy.
  • We prospectively evaluated the yield and accuracy of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) in sampling mediastinal lymph nodes and compared its accuracy to that of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) and CT in staging NSCLC.
  • METHODS: A consecutive series of patients with suspicious nodes on PET or CT scan in the posterior mediastinal lymph node stations (#5, 7, 8, or 9) were prospectively evaluated by EUS-FNA.
  • The reference standard included thoracotomy with complete lymphadenectomy in patients with lung cancer or if EUS-FNA was benign, repeat clinical imaging, or long-term follow-up.
  • RESULTS: There were 104 patients (63 men) with 125 lesions (117 lymph nodes, 8 left adrenal glands) who underwent EUS-FNA.
  • EUS-FNA was more accurate and had a higher positive predictive value than the PET or CT (p < 0.001) scan in confirming cancer in the posterior mediastinal lymph nodes.
  • It is more accurate and has a higher predictive value than either the PET scan or CT scan for posterior mediastinal lymph nodes.
  • [MeSH-major] Biopsy, Fine-Needle. Carcinoma, Non-Small-Cell Lung / secondary. Esophagoscopy. Lung Neoplasms / pathology. Lymphatic Diseases / pathology. Lymphatic Metastasis / pathology. Neoplasm Staging / methods. Positron-Emission Tomography. Tomography, X-Ray Computed. Ultrasonography, Interventional
  • [MeSH-minor] Aged. Breast Neoplasms / pathology. Carcinoma / pathology. Carcinoma / radiography. Carcinoma / radionuclide imaging. Carcinoma / secondary. Carcinoma / ultrasonography. Colonic Neoplasms / pathology. Endometrial Neoplasms / pathology. Female. Fluorodeoxyglucose F18. Granuloma / diagnosis. Histiocytosis / complications. Histiocytosis / diagnosis. Histoplasmosis / complications. Histoplasmosis / diagnosis. Humans. Kidney Neoplasms / pathology. Lung Diseases / complications. Lymphoma / pathology. Lymphoma / radiography. Lymphoma / radionuclide imaging. Lymphoma / ultrasonography. Male. Mediastinum. Middle Aged. Predictive Value of Tests. Prospective Studies. Radiopharmaceuticals. Sarcoidosis / complications. Sarcoidosis / diagnosis. Silicosis / complications. Silicosis / diagnosis. Urinary Bladder Neoplasms / pathology


14. Wang XT, Sienel W, Eggeling S, Ludwig C, Stoelben E, Mueller J, Klein CA, Passlick B: Detection of disseminated tumor cells in mediastinoscopic lymph node biopsies and lymphadenectomy specimens of patients with NSCLC by quantitative RT-PCR. Eur J Cardiothorac Surg; 2005 Jul;28(1):26-32
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  • [Title] Detection of disseminated tumor cells in mediastinoscopic lymph node biopsies and lymphadenectomy specimens of patients with NSCLC by quantitative RT-PCR.
  • OBJECTIVE: Detection of disseminated tumor cells in mediastinoscopic biopsies could improve staging and might be helpful concerning indications for neoadjuvant therapy regimens.
  • This prospective study was performed to evaluate a simple and observer-independent polymerase chain reaction (PCR)-based method for the detection of disseminated tumor cells in regional lymph nodes.
  • METHODS: Lymph nodes of 32 consecutive patients without neoadjuvant therapy were removed by systematic lymphadenectomy during resection of primary NSCLC.
  • One hundred of these lymph nodes were cut into two equal halves which were examined using either routine histopathology or quantitative reverse transcriptase PCR (qRT-PCR).
  • qRT-PCR amplification of cytokeratin 19 (CK19) transcripts was applied for the detection of tumor cell-specific RNA.
  • We differentiated between illegitimate marker gene transcription and cancer-specific expression by using a cut-off value that was obtained from the analysis of 18 lymph nodes of patients with benign lung diseases.
  • RESULTS: Ninety-four (94%) lymph nodes were tumor-free by histopathology. qRT-PCR detected disseminated tumor cells in 26 (28%) of these lymph nodes.
  • All of the remaining six lymph nodes that were judged by the pathologist to contain tumor cells exhibited CK19 transcripts.
  • Twenty-three patients had a pN0 status. qRT-PCR detected disseminated tumor cells in 13 (56%) of these pN0 patients.
  • The mediastinoscopic biopsies showed disseminated tumor cells in four (21%) out of 19 histopathologically tumor-free samples.
  • CONCLUSIONS: CK19 qRT-PCR is a sensitive and specific tools for the detection of disseminated tumor cells in regional lymph nodes of patients with operable NSCLC.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / secondary. Lung Neoplasms / pathology. Lymph Nodes / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / biosynthesis. Biomarkers, Tumor / genetics. Biopsy. Female. Humans. Keratins / biosynthesis. Keratins / genetics. Lymph Node Excision. Lymphatic Metastasis / pathology. Male. Mediastinoscopy. Mediastinum. Middle Aged. Neoplasm Staging. Prospective Studies. RNA, Neoplasm / genetics. Reverse Transcriptase Polymerase Chain Reaction / methods. Sensitivity and Specificity

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  • (PMID = 15939599.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Neoplasm; 68238-35-7 / Keratins
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15. Lee BE, Redwine J, Foster C, Abella E, Lown T, Lau D, Follette D: Mediastinoscopy might not be necessary in patients with non-small cell lung cancer with mediastinal lymph nodes having a maximum standardized uptake value of less than 5.3. J Thorac Cardiovasc Surg; 2008 Mar;135(3):615-9
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  • [Title] Mediastinoscopy might not be necessary in patients with non-small cell lung cancer with mediastinal lymph nodes having a maximum standardized uptake value of less than 5.3.
  • The maximum standardized uptake value obtained with integrated fluorodeoxyglucose-positron emission tomography/computed tomography has been proposed to be a predictor of malignancy in mediastinal lymph nodes.
  • A recent study has also suggested that accuracy of integrated fluorodeoxyglucose-positron emission tomography/computed tomography might be improved by increasing the maximum standardized uptake value used for calling a lymph node positive from 2.5 to 5.3.
  • We tested the hypotheses that the maximum standardized uptake value is a predictor of individual lymph node metastasis in non-small cell lung cancer and that pathologic staging with mediastinoscopy might not be necessary in patients with a maximum standardized uptake value of less than 5.3 in their mediastinal lymph nodes.
  • METHODS: This is a retrospective review of 765 lymph nodes sampled from 110 patients in a single institution with biopsy-proved non-small cell lung cancer.
  • All patients underwent integrated fluorodeoxyglucose-positron emission tomography/computed tomography before biopsy or resection of their mediastinal lymph nodes.
  • All N2 lymph nodes were individually assessed according to station.
  • RESULTS: Twenty-one (19%) of 110 patients had N2 disease, and a total of 765 N2 lymph nodes were pathologically examined.
  • The mean and median maximum standardized uptake values for N2 nodes with metastatic disease were 9.2 (95% confidence interval, 7.0-11.4) and 7.2 (range, 2.2-25.8), respectively.
  • For benign N2 nodes, the mean and median maximum standardized uptake values were 1.5 (95% confidence interval, 1.4-1.6) and 1.0 (range, 1.0-9.6), respectively (P < .05).
  • CONCLUSIONS: The maximum standardized uptake value is a predictor of individual lymph node metastasis in non-small cell lung cancer.
  • More importantly, these results suggest that some patients with non-small cell lung cancer with a maximum standardized uptake value less than 5.3 in their N2 lymph nodes might be able to forego mediastinoscopy and proceed directly to thoracotomy.
  • This represents a significant change in the current management of standardized uptake value-positive mediastinal lymph nodes in non-small cell lung cancer.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / pathology. Lung Neoplasms / pathology. Lymph Nodes / pathology. Lymph Nodes / radionuclide imaging. Neoplasm Invasiveness / pathology. Positron-Emission Tomography
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Needle. Cohort Studies. Female. Humans. Immunohistochemistry. Lymph Node Excision / methods. Male. Mediastinoscopy / methods. Middle Aged. Neoplasm Staging. Pneumonectomy / methods. Pneumonectomy / mortality. Predictive Value of Tests. Probability. Prognosis. Retrospective Studies. Risk Assessment. Statistics, Nonparametric. Survival Analysis. Treatment Outcome


16. Vansteenkiste JF, Stroobants SS: PET scan in lung cancer: current recommendations and innovation. J Thorac Oncol; 2006 Jan;1(1):71-3
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  • FDG-PET is recommended for the diagnosis of indeterminate pulmonary nodules, for which it is significantly more accurate than computed tomography (CT) in the distinction between benign and malignant lesions.
  • A large body of evidence convincingly demonstrates that loco-regional lymph node staging by FDG-PET (in correlation with CT images) is significantly superior to CT alone, with a negative predictive value equal or even superior to mediastinoscopy.
  • [MeSH-minor] Diagnosis, Differential. Fluorodeoxyglucose F18. Humans. Neoplasm Staging / methods. Radiopharmaceuticals. Reproducibility of Results

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  • (PMID = 17409830.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 19
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17. Leshnower BG, Miller DL, Fernandez FG, Pickens A, Force SD: Video-assisted thoracoscopic surgery segmentectomy: a safe and effective procedure. Ann Thorac Surg; 2010 May;89(5):1571-6
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  • There was no difference in tumor size, number of lymph node stations sampled, or number of lymph nodes removed based upon approach.
  • The remaining indications for surgery were metastatic disease in 12 patients and benign disease in 4 patients.
  • [MeSH-major] Pneumonectomy / methods. Thoracic Surgery, Video-Assisted / methods. Thoracotomy / methods
  • [MeSH-minor] Aged. Carcinoma, Non-Small-Cell Lung / mortality. Carcinoma, Non-Small-Cell Lung / pathology. Carcinoma, Non-Small-Cell Lung / surgery. Cohort Studies. Disease-Free Survival. Female. Follow-Up Studies. Hospital Mortality / trends. Humans. Length of Stay / trends. Lung Neoplasms / mortality. Lung Neoplasms / pathology. Lung Neoplasms / surgery. Male. Middle Aged. Minimally Invasive Surgical Procedures / methods. Minimally Invasive Surgical Procedures / mortality. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Postoperative Complications / diagnosis. Postoperative Complications / mortality. Probability. Retrospective Studies. Risk Assessment. Survival Analysis. Treatment Outcome

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  • [Copyright] Copyright (c) 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20417779.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
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18. Kumasaka T, Seyama K, Mitani K, Souma S, Kashiwagi S, Hebisawa A, Sato T, Kubo H, Gomi K, Shibuya K, Fukuchi Y, Suda K: Lymphangiogenesis-mediated shedding of LAM cell clusters as a mechanism for dissemination in lymphangioleiomyomatosis. Am J Surg Pathol; 2005 Oct;29(10):1356-66
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  • Recent studies indicate that LAM cells can migrate or metastasize to form new lesions in multiple organs, although they show a morphologically benign appearance.
  • In this study, we further focused on the lymphatic abnormalities in LAM: LAM-associated chylous fluid (5 pleural effusion and 2 ascites), surgically resected diaphragm (1 patient), and axial lymphatic system including the thoracic duct, lymph nodes at various regions, and diaphragmatic lymphatic system (5 autopsy cases).
  • We identified LAM lesion in the diaphragm (2 of 5 autopy cases and one surgical specimen), thoracic duct (5 of 5), and lymph nodes (retroperitoneal (5 of 5), mediastinal (4 of 5), left venous angle (5 of 5) with total positive rate of 68% to 88% at each region of the lymph node, but less frequent or none at remote lymph nodes located away from the axial lymph trunk (cervical [1 of 5] and axillary [0 of 5]).
  • [MeSH-major] Endothelial Cells / pathology. Lymphangiogenesis. Lymphangioleiomyomatosis / pathology. Neoplasm Metastasis / pathology. Neoplastic Cells, Circulating / pathology
  • [MeSH-minor] Adult. Chylous Ascites / etiology. Female. Humans. Immunohistochemistry. Thoracic Duct / pathology


19. Cerfolio RJ, Bryant AS, Ojha B: Restaging patients with N2 (stage IIIa) non-small cell lung cancer after neoadjuvant chemoradiotherapy: a prospective study. J Thorac Cardiovasc Surg; 2006 Jun;131(6):1229-35
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  • RESULTS: Ninety-three patients had their lymph nodes pathologically restaged.
  • When the maximum standardized uptake value of the primary tumor is decreased by 75% or more, it is highly likely (likelihood ratio, +LR, 6.1) the patient is a complete responder; when it decreased by 55% or more, it is highly likely (+LR, 9.1) the patient is a partial responder.
  • When the maximum standardized uptake value of the N2 node initially involved with metastatic cancer is decreased by more than 50%, it is highly likely (+LR, 7.9) the node is now benign.
  • The percent decrease in the maximum standardized uptake value of the primary and of the involved lymph node is predictive of pathology; however, nodal biopsies are required since a persistently high maximum standardized uptake value does not equate to residual cancer.
  • [MeSH-minor] Adult. Aged. Algorithms. Chemotherapy, Adjuvant. Female. Humans. Male. Middle Aged. Neoplasm Staging. Positron-Emission Tomography. Prospective Studies. Radiotherapy, Adjuvant. Reproducibility of Results. Tomography, X-Ray Computed

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  • [CommentIn] J Thorac Cardiovasc Surg. 2007 Jan;133(1):275-6; author reply 276-7 [17198837.001]
  • [CommentIn] J Thorac Cardiovasc Surg. 2006 Jun;131(6):1227-8 [16733149.001]
  • [ErratumIn] J Thorac Cardiovasc Surg. 2006 Sep;132(3):565-7
  • (PMID = 16733150.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] United States
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20. Meyers BF, Haddad F, Siegel BA, Zoole JB, Battafarano RJ, Veeramachaneni N, Cooper JD, Patterson GA: Cost-effectiveness of routine mediastinoscopy in computed tomography- and positron emission tomography-screened patients with stage I lung cancer. J Thorac Cardiovasc Surg; 2006 Apr;131(4):822-9; discussion 822-9
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  • An important goal of preoperative staging is to identify mediastinal lymph node metastasis.
  • Computed tomography and positron emission tomography may identify mediastinal lymph node metastasis with sufficient sensitivity to allow omission of mediastinoscopy.
  • METHODS: We retrospectively reviewed our thoracic surgery database for cases between May 1999 and May 2004.
  • A decision model was created using TreeAgePro software and our observed data for the prevalence of mediastinal lymph node metastases and for the rate of benign nodules.
  • An additional 9 patients were found to have N2 metastasis in the final resected specimen, resulting in a total of 14/248 patients (5.6%) with occult mediastinal lymph node metastases.
  • Benign nodules were found in 19/248 (8%) of patients.
  • [MeSH-minor] Bromhexine. Chemotherapy, Adjuvant. Cost-Benefit Analysis. Disease Progression. Humans. Lymphatic Metastasis. Missouri. Neoplasm Staging. Positron-Emission Tomography. Quality-Adjusted Life Years. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 16580440.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] Q1J152VB1P / Bromhexine
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21. Hürtgen M, Friedel G, Witte B, Toomes H, Fritz P: Systematic Video-Assisted Mediastinoscopic Lymphadenectomy (VAMLA). Thorac Surg Sci; 2005;2:Doc02
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  • Accurate mediastinal lymph node dissection during thoracotomy is mandatory for staging and for adjuvant therapy in lung cancer.
  • Lymph nodes were counted and compared to open lymphadenectomy.
  • Mean duration of anaesthesia was 84.6 (SD 35.8) minutes.In 7 patients radical lymphadenectomy was not intended because of bulky nodal disease or benign disease.
  • In two patients, 1 and 2 left over paratracheal nodes were counted respectively.
  • In 6 patients one single node and in the remaining 2 cases 5 and 8 nodes were found, respectively.
  • However these counts also included nodes from the ipsilateral main bronchus.
  • None of these nodes was positive for tumour.Average weight of the tissue that was harvested by VAMLA was 10.1 g (2.2-23.7, SD 6.3).
  • An average number of 20.5 (6-60, SD 12.5) nodes per patient were counted in the specimens.
  • This is comparable to our historical data from open lymphadenectomy.One palsy of the recurrent nerve in a patient with extensive preparation of the nerve and resection of 11 left-sided enlarged nodes was the only severe complication in this series.VAMLA seems to accomplish mediastinal nodal dissection comparable to open lymphadenectomy and supports video assisted surgery for lung cancer.

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  • (PMID = 21289921.001).
  • [ISSN] 1862-4006
  • [Journal-full-title] Thoracic surgical science
  • [ISO-abbreviation] Thorac Surg Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC3011310
  • [Keywords] NOTNLM ; carcinoma, non-small-cell lung / lung neoplasm / mediastinoscopy / neoplasm staging / video-assisted surgery
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22. Iwata T, Nishiyama N, Nagano K, Izumi N, Tsukioka T, Hanada S, Kimura T, Kudoh S, Hirata K, Suehiro S: Squamous cell carcinoma presenting as a solitary growing cyst in lung: a diagnostic pitfall in daily clinical practice. Ann Thorac Cardiovasc Surg; 2009 Jun;15(3):174-7
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  • Thin-walled cavitary lung cancer is a rare entity; however, it could be a pitfall in the diagnosis of such radiographically benign-looking lesions, especially without an obvious solid, nodular, or tumorous appearance in the lesion.
  • We herein report a rare case of lung cancer successfully treated by surgical resection that appeared as a gradually growing cystic lesion mimicking benign emphysematous disease, with a review of the literature.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Cysts / diagnosis. Diagnostic Errors / prevention & control. Lung Neoplasms / diagnosis. Solitary Pulmonary Nodule / diagnosis
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols. Biopsy. Carboplatin / administration & dosage. Chemotherapy, Adjuvant. Frozen Sections. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Neoplasm Staging. Paclitaxel / administration & dosage. Pneumonectomy. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • (PMID = 19597393.001).
  • [ISSN] 2186-1005
  • [Journal-full-title] Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
  • [ISO-abbreviation] Ann Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
  • [Number-of-references] 5
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23. Cerfolio RJ, Bryant AS: Survival of patients with true pathologic stage I non-small cell lung cancer. Ann Thorac Surg; 2009 Sep;88(3):917-22; discussion 922-3
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  • All patients had an integrated positron-emission tomography/computed tomography (CT) and CT scan, an R0 pulmonary resection with lung palpation, and complete thoracic lymphadenectomy.
  • Of the 721 (c)stage I, 405 (56%) had (p)stage I disease; 101 (14%) were clinically over-staged (benign nodules).
  • CONCLUSIONS: When patients with NCSLC are accurately staged preoperatively and undergo complete thoracic lymphadenectomy, the 5-year survival is 80% for (p)stage IA tumors and 87% for (c)stage I disease.
  • About 32% of patients are under-staged (most commonly from nonimaged N2 disease) despite the liberal application of all of the techniques that assess mediastinal lymph nodes preoperatively.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Algorithms. Biopsy. Disease-Free Survival. Female. Humans. Image Processing, Computer-Assisted. Lung / pathology. Lymph Node Excision. Lymph Nodes / pathology. Male. Middle Aged. Neoplasm Staging. Pneumonectomy. Positron-Emission Tomography. Predictive Value of Tests. Prognosis. Retrospective Studies. Tomography, X-Ray Computed. Young Adult


24. Chen G, Liu XY, Wang Z, Liu FY: Vascular endothelial growth factor C: the predicator of early recurrence in patients with N2 non-small-cell lung cancer. Eur J Cardiothorac Surg; 2010 Mar;37(3):546-51
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  • OBJECTIVE: Mediastinal lymph node metastasis (N2) is a key prognostic factor for lung carcinoma.
  • METHODS: Cancer tissue samples from 92 patients with pN2 non-small-cell lung cancer and benign lung disease tissues samples from 30 patients were examined by reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry assays to detect VEGF-C expression.
  • RESULTS: VEGF-C mRNA expression was observed in 64 (70%) pN2 lung cancer tissues, but was not found in benign lung disease tissues.
  • About one-half of the patients with N2 non-small-cell lung cancer would develop recurrence disease within 1 year after surgery, frequently with mediastinal nodes, brain or lung metastases.
  • [MeSH-major] Biomarkers, Tumor / biosynthesis. Carcinoma, Non-Small-Cell Lung / metabolism. Lung Neoplasms / metabolism. Vascular Endothelial Growth Factor C / biosynthesis
  • [MeSH-minor] Adult. Aged. Brain Neoplasms / secondary. Chemotherapy, Adjuvant. Epidemiologic Methods. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. RNA, Messenger / genetics. RNA, Neoplasm / genetics. Radiotherapy, Adjuvant. Reverse Transcriptase Polymerase Chain Reaction / methods

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  • [Copyright] Copyright (c) 2009 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
  • (PMID = 19758816.001).
  • [ISSN] 1873-734X
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / VEGFC protein, human; 0 / Vascular Endothelial Growth Factor C
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25. Komatsu T, Fukuse T, Wada H, Sakurai T: Pulmonary sclerosing hemangioma with pulmonary metastasis. Thorac Cardiovasc Surg; 2006 Aug;54(5):348-9
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  • Pulmonary sclerosing hemangioma is a relatively rare neoplasm.
  • Although it is thought to be benign, cases with lymph node metastasis or multiple pulmonary involvement have been reported in clinical settings.
  • [MeSH-minor] Aged. Female. Humans. Lymphatic Metastasis. Thoracic Surgery, Video-Assisted

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  • (PMID = 16902885.001).
  • [ISSN] 0171-6425
  • [Journal-full-title] The Thoracic and cardiovascular surgeon
  • [ISO-abbreviation] Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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26. Varadarajulu S, Eloubeidi M: Can endoscopic ultrasonography-guided fine-needle aspiration predict response to chemoradiation in non-small cell lung cancer? A pilot study. Respiration; 2006;73(2):213-20
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  • BACKGROUND: Accurate prediction of pathologic response to chemoradiation (CHEMO-XRT) has a significant impact on the treatment of patients with non-small cell lung cancer (NSCLC) and mediastinal lymph node (LN) metastasis (N2 disease).
  • Those staged N0 by EUS underwent tumor resection with complete LN dissection.
  • Eleven of 14 patients in whom mediastinal LN were seen at restaging by EUS underwent FNA: the aspirate was benign in 4, residual disease was found in 6, and an inadequate sample was obtained in 1 patient.
  • Final diagnosis on the 7 patients in whom EUS suggested N0 disease was established at surgery: EUS was true negative in 6 and false negative in 1.
  • Of the 6 patients with residual disease, 5 underwent palliative CHEMO-XRT and 1 underwent extended tumor resection.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / therapy. Endoscopy / methods. Lung Neoplasms / therapy. Mediastinal Neoplasms / secondary. Neoplasm, Residual / diagnosis
  • [MeSH-minor] Aged. Biopsy, Fine-Needle. Chemotherapy, Adjuvant. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Pilot Projects. Predictive Value of Tests. Prospective Studies. Radiotherapy, Adjuvant. Retrospective Studies


27. Liu Z, Xu S, Xiao N, Song C, Zhang H, Li F: [Overexpression of IL-8 and MMP-9 confer high malignant phenotype in patients with non-small cell lung cancer]. Zhongguo Fei Ai Za Zhi; 2010 Aug;13(8):795-802
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  • BACKGROUND AND OBJECTIVE: IL-8 (interleukin-8) has been identified as a chemotactic factor, but recent found that IL-8 and matrix metalloproteinase-9 (MMP-9) are important cytokines which are closely related to the growth and metastasis of tumor.
  • The aim of this study is to explore the relationship between IL-8, MMP-9 expressions and clinical pathological features of non-small cell lung cancer (NSCLC) patients and evaluate the diagnostic potential of IL-8, MMP-9 as tumor markers.
  • METHODS: The serum levels of IL-8 and MMP-9 were detected by enzyme-linked immunosorbentassay (ELISA) in 141 NSCLC patients, 40 healthy adults and 40 patients with benign pulmonary disease.
  • The expressions of IL-8 and MMP-9 were detected by immunohistochemical method in 95 NSCLC tissues, and 21 benign disease lung tissues, 25 normal lung tissues as control.
  • RESULTS: The level of expression of IL-8 and MMP-9 in serum and tissue of NSCLC was significantly higher than that of healthy and benign respiratory disease, and the expression was gradually increased with the upgrade of clinicopathological stage.
  • The serum and tissue expression of IL-8 and MMP-9 in NSCLC patients with lymph node metastasis was remarkably higher than that without lymph node metastasis.
  • There is an obvious correlation between IL-8 expression and lymph node metastasis, IL-8 may facilitate the lymph node metastasis by up-regulating MMP-9 expression.
  • Serum level of IL-8 is a valuable auxiliary parameter in diagnosing lymph node metastases of NSCLC with good sensitivity and specificity.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Case-Control Studies. Female. Humans. Male. Middle Aged. Neoplasm Metastasis

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  • (PMID = 20704821.001).
  • [ISSN] 1999-6187
  • [Journal-full-title] Zhongguo fei ai za zhi = Chinese journal of lung cancer
  • [ISO-abbreviation] Zhongguo Fei Ai Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Interleukin-8; EC 3.4.24.35 / Matrix Metalloproteinase 9
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28. D'Cunha J, Herndon JE 2nd, Herzan DL, Patterson GA, Kohman LJ, Harpole DH, Kernstine KH, Kern JA, Green MR, Maddaus MA, Kratzke RA, Cancer and Leukemia Group B: Poor correspondence between clinical and pathologic staging in stage 1 non-small cell lung cancer: results from CALGB 9761, a prospective trial. Lung Cancer; 2005 May;48(2):241-6
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  • Patients with clinically suspected resectable early stage lung cancer were eligible for enrollment if they had no evidence of mediastinal or hilar adenopathy on CT scan or if they had CT evidence of potential N2 or N3 disease (lymph node > or =1.0 cm) but with negative mediastinoscopy.
  • Of the patients undergoing resection for clinical stage 1 NSCLC, 65 patients did not have NSCLC (44 had benign disease and 21 had malignancies other than NSCLC) and two additional patients had dual synchronous primary NSCLC tumors and were not eligible for the study.
  • Overall, only 61.7% (302 of 489) of patients with suspected stage 1 NSCLC disease retained that stage and diagnosis after complete surgical staging, while 38.3% had an inaccurate pre-operative clinical stage or diagnosis.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / pathology. Lung Neoplasms / pathology. Neoplasm Staging / methods. Neoplasm Staging / standards

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  • (PMID = 15829324.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA04326; United States / NCI NIH HHS / CA / CA12046; United States / NCI NIH HHS / CA / CA16450; United States / NCI NIH HHS / CA / CA21060; United States / NCI NIH HHS / CA / CA31946; United States / NCI NIH HHS / CA / CA31983; United States / NCI NIH HHS / CA / CA32291; United States / NCI NIH HHS / CA / CA47577; United States / NCI NIH HHS / CA / CA47642; United States / NCI NIH HHS / CA / CA77440
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Ireland
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29. Lee JW, Kim BS, Lee DS, Chung JK, Lee MC, Kim S, Kang WJ: 18F-FDG PET/CT in mediastinal lymph node staging of non-small-cell lung cancer in a tuberculosis-endemic country: consideration of lymph node calcification and distribution pattern to improve specificity. Eur J Nucl Med Mol Imaging; 2009 Nov;36(11):1794-802
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  • [Title] 18F-FDG PET/CT in mediastinal lymph node staging of non-small-cell lung cancer in a tuberculosis-endemic country: consideration of lymph node calcification and distribution pattern to improve specificity.
  • PURPOSE: The aim of the study was to assess the accuracy of (18)F-fluorodeoxyglucose (FDG) PET/CT in mediastinal lymph node staging of patients with non-small-cell lung cancer (NSCLC) in a region with a high prevalence of granulomatous disease.
  • METHODS: Between March 2004 and February 2006, all patients with NSCLC underwent FDG PET/CT and contrast-enhanced thoracic CT, and subsequent surgical resection.
  • Mediastinal node staging was determined using the American Joint Committee on Cancer (AJCC) staging system.
  • RESULTS: A total of 182 patients with 778 mediastinal node stations were evaluated.
  • Sensitivity and specificity of contrast-enhanced CT were 36% and 80% on a per-patient basis and 23% and 92% on a per-node station basis.
  • Sensitivity and specificity of PET/CT were 81% and 73% on a per-patient basis and 75% and 85% on a per-node station basis.
  • After lymph nodes with calcification and bilateral hilar distribution were considered benign, sensitivity and specificity of PET/CT were 75% and 89% on a per-patient basis and 66% and 96% on a per-node station basis.
  • CONCLUSION: This prospective study suggests that FDG PET/CT can more accurately stage mediastinal lymph nodes than CT.
  • Considering lymph node calcification and distribution pattern could improve specificity at the cost of a decrease in sensitivity.
  • [MeSH-major] Calcinosis. Carcinoma, Non-Small-Cell Lung / pathology. Fluorodeoxyglucose F18. Lung Neoplasms / pathology. Lymph Nodes / pathology. Mediastinum. Tuberculosis / complications
  • [MeSH-minor] Contrast Media. Endemic Diseases. False Positive Reactions. Female. Humans. Male. Middle Aged. Neoplasm Staging. Positron-Emission Tomography. Radiography, Thoracic. Sensitivity and Specificity. Tomography, X-Ray Computed


30. Fujiwara T, Yasufuku K, Nakajima T, Chiyo M, Yoshida S, Suzuki M, Shibuya K, Hiroshima K, Nakatani Y, Yoshino I: The utility of sonographic features during endobronchial ultrasound-guided transbronchial needle aspiration for lymph node staging in patients with lung cancer: a standard endobronchial ultrasound image classification system. Chest; 2010 Sep;138(3):641-7
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  • [Title] The utility of sonographic features during endobronchial ultrasound-guided transbronchial needle aspiration for lymph node staging in patients with lung cancer: a standard endobronchial ultrasound image classification system.
  • BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive procedure with a high yield for lymph node staging of lung cancer.
  • The aim of this study was to assess the utility of sonographic features of lymph nodes during EBUS-TBNA for the prediction of metastasis in patients with lung cancer and to establish a standard endobronchial ultrasound (EBUS) image classification system.
  • METHODS: Digital images of lymph nodes obtained during EBUS-TBNA in patients with lung cancer were categorized according to the following characteristics:.
  • RESULTS: A total of 1,061 lymph nodes were retrospectively evaluated in 487 patients.
  • Two hundred eighty-five of the 664 lymph nodes (42.9%) having at least one metastatic feature of the four categories were pathologically proven metastatic, and 96.0% of lymph nodes (381/397) were proven not metastatic when all four categories were determined as benign.
  • CONCLUSIONS: Sonographic features of lymph nodes based on the new EBUS imaging classification may be helpful in the prediction of metastatic lymph nodes during EBUS-TBNA.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle / methods. Cohort Studies. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging / methods. Predictive Value of Tests. Retrospective Studies


31. Yang HX, Wu YL, Ding JA, Jiang GN, Zhou X, Chen C, Gao W, Chen G: [Detection of micrometastasis in mediastinal lymph nodes in operable non-small cell lung cancers]. Zhonghua Zhong Liu Za Zhi; 2006 May;28(5):368-70
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  • [Title] [Detection of micrometastasis in mediastinal lymph nodes in operable non-small cell lung cancers].
  • OBJECTIVE: Using the LUNX-mRNA as a marker and RT-PCR technique to assess mediastinal lymph nodes in patients with operable NSCLC, to evaluate at gene level the feasibility of this method in detection of micrometastasis in NSCLC and the necessity of systematic mediastinal lymphadenectomy during surgery.
  • The mediastinal lymph nodes were taken during operation.
  • Ten cases with benign lung disease were assayed by the same method as control.
  • RESULTS: Seventy one mediastinal lymph nodes were obtained from 20 patients, 8 (11.3%) of which showed histologically metastasis with HE staining, while 23 (32.4%) were LUNX-mRNA positive by RT-PCR, P < 0.001.
  • Micrometastasis was detected in 25.4% of all lymph nodes.
  • LUNX-mRNA was found to be positive in 23.6% of lymph nodes from 15 patients with stage I A-II B NSCLC compared with 62.5% from 5 patients with stage III NSCLC, with a significant difference (P = 0.003).
  • CONCLUSION: About 25.4% of mediastinal lymph nodes are with micrometastasis in patients with operable NSCLC.
  • Systematic mediastinal lymphadenectomy is necessary to deal with the regional lymph nodes during surgery.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / secondary. Lung Neoplasms / pathology. Lymph Node Excision. Lymph Nodes / pathology
  • [MeSH-minor] Adult. Aged. Female. Glycoproteins / biosynthesis. Glycoproteins / genetics. Humans. Lymphatic Metastasis. Male. Mediastinum. Middle Aged. Neoplasm Staging. Phosphoproteins / biosynthesis. Phosphoproteins / genetics. RNA, Messenger / biosynthesis. RNA, Messenger / genetics

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  • (PMID = 17045003.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / BPIFA1 protein, human; 0 / Glycoproteins; 0 / Phosphoproteins; 0 / RNA, Messenger
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32. Vincent BD, El-Bayoumi E, Hoffman B, Doelken P, DeRosimo J, Reed C, Silvestri GA: Real-time endobronchial ultrasound-guided transbronchial lymph node aspiration. Ann Thorac Surg; 2008 Jan;85(1):224-30
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  • [Title] Real-time endobronchial ultrasound-guided transbronchial lymph node aspiration.
  • BACKGROUND: Accurate staging of lung cancer requires noninvasive and pathologic examination of intrathoracic lymphadenopathy, which determines both the treatment options and prognosis.
  • METHODS: This was a retrospective analysis of 152 consecutive patients who underwent EBUS-TBNA with undiagnosed intrathoracic adenopathy or cancer staging as the primary indications.
  • Of the 152 patients, 117 were included in the final statistical analysis after excluding those with benign disease diagnosed by EBUS-TBNA.
  • Four patients had benign diagnoses at surgical pathology.
  • Only 1 surgical patient was found to have nodal metastasis at a lymph node station previously biopsied by EBUS-TBNA (negative predictive value, 97%).
  • CONCLUSIONS: EBUS-TBNA is useful in accessing mediastinal and hilar lymph nodes for the diagnosis and staging of non-small cell lung cancer and other disorders of the mediastinum.
  • Thoracic surgeons and pulmonologists are well positioned to use this tool in everyday practice.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Bronchoscopes. Endosonography / methods. Lung Neoplasms / pathology. Lymph Nodes / pathology. Lymph Nodes / ultrasonography
  • [MeSH-minor] Academic Medical Centers. Adult. Aged. Equipment Design. Female. Humans. Male. Mediastinal Neoplasms / pathology. Mediastinal Neoplasms / surgery. Middle Aged. Neoplasm Staging. Predictive Value of Tests. Preoperative Care. Prognosis. Retrospective Studies. Risk Assessment. Sensitivity and Specificity

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  • (PMID = 18154815.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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33. Morikawa M, Demura Y, Ishizaki T, Ameshima S, Miyamori I, Sasaki M, Tsuchida T, Kimura H, Fujibayashi Y, Okazawa H: The effectiveness of 18F-FDG PET/CT combined with STIR MRI for diagnosing nodal involvement in the thorax. J Nucl Med; 2009 Jan;50(1):81-7
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  • The purpose of this study was to compare the efficacy of short-tau inversion-recovery (STIR) MRI and 18F-FDG PET/CT for the detection of metastasis in mediastinal and hilar lymph nodes in patients with lung cancer.
  • METHODS: Ninety-three patients with known or suspected lung cancer with mediastinal and hilar lymph node swelling underwent STIR MRI and 18F-FDG PET/CT examinations.
  • STIR MRI scans were obtained with a 2% copper sulfate phantom placed along the back of each patient, with the lymph node-to-phantom ratio calculated for quantitative analysis.
  • To evaluate the diagnostic capabilities of STIR MRI and 18F-FDG PET/CT, we used receiver-operating-characteristic curve analysis to determine the optimal thresholds for the lymph node-to-phantom ratio, visual score, and maximal standardized uptake value.
  • RESULTS: A total of 137 lymph nodes (82 malignant lesions, 55 benign lesions) were analyzed.
  • [MeSH-major] Fluorodeoxyglucose F18. Lung Neoplasms / pathology. Lymphatic Metastasis / radiography. Lymphatic Metastasis / radionuclide imaging. Radiography, Thoracic. Thorax / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Magnetic Resonance Imaging. Male. Mediastinal Neoplasms / radiography. Mediastinal Neoplasms / radionuclide imaging. Mediastinal Neoplasms / secondary. Middle Aged. Neoplasm Staging. Phantoms, Imaging. Positron-Emission Tomography. Sensitivity and Specificity. Tomography, X-Ray Computed

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  • (PMID = 19091887.001).
  • [ISSN] 0161-5505
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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34. Chen F, Sato T, Fujinaga T, Sakai H, Miyahara R, Bando T, Date H: Surgical management of bronchopulmonary typical carcinoid tumors: an institutional experience. Interact Cardiovasc Thorac Surg; 2010 Dec;11(6):737-9
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  • Bronchopulmonary typical carcinoid tumors are well known as low-grade malignant tumors with fairly benign behaviors; however, distant metastasis after complete resection and multiple carcinoid tumors in the resected lungs have been sporadically reported.
  • [MeSH-major] Bronchial Neoplasms / surgery. Carcinoid Tumor / surgery. Pneumonectomy
  • [MeSH-minor] Adult. Aged. Biopsy. Bronchoscopy. Female. Humans. Japan. Liver Neoplasms / secondary. Lymph Node Excision. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Time Factors. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20852330.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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