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1. Yoshida S, Masuda H, Ishii C, Saito K, Kawakami S, Kihara K: Initial experience of functional imaging of upper urinary tract neoplasm by diffusion-weighted magnetic resonance imaging. Int J Urol; 2008 Feb;15(2):140-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Initial experience of functional imaging of upper urinary tract neoplasm by diffusion-weighted magnetic resonance imaging.
  • OBJECTIVES: Diffusion-weighted (DW) magnetic resonance imaging (MRI) provides functional information widely used in the diagnosis of acute cerebral stroke.
  • We reported our initial experience of this imaging technique of upper urinary tract (UUT) urothelial carcinoma (UC).
  • The last patient was confirmed as experiencing benign stenosis.
  • The apparent diffusion coefficient (ADC) values of renal parenchyma, dilated collecting system, and tumor were calculated.
  • RESULTS: On DW MRI, all nine tumors showed hyperintensity with negligible urinary intensity.
  • The case of benign stenosis had negative DW MRI.
  • The median (range) ADC value of the tumor (0.803 [0.412-0.958] x 10(-3) mm(2)/s) was significantly lower than those of the dilated collecting system (2.19 [1.42-2.40] x 10(-3)) and renal parenchyma (1.28 [0.922-1.45] x 10(-3), respectively (P < 0.01 and P < 0.01).
  • [MeSH-major] Carcinoma / diagnosis. Diffusion Magnetic Resonance Imaging. Urologic Neoplasms / diagnosis

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  • (PMID = 18269448.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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2. Bjornsson B, Birgisson G, Oddsdottir M: Laparoscopic adrenalectomies: A nationwide single-surgeon experience. Surg Endosc; 2008 Mar;22(3):622-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Since then, all procedures for presumed benign lesions of the adrenals have been performed laparoscopically in a single center.
  • The preoperative diagnosis was documented, as well as the pathologic diagnosis, operative details, complications, and length of hospital stay.
  • The complications were mild pancreatitis (n = 1), urinary tract infection (n = 1), atelectasis (n = 1), mild congestive heart failure (n = 2), and transient corneal abrasion (n = 1).
  • The mean tumor size was 3.5 cm (range, 1.5-6.2 cm), and the mean postoperative hospital stay was 2.6 days (range, 1-6 days).
  • CONCLUSION: The results of laparoscopic adrenalectomies in Iceland for benign lesions of the adrenals are comparable with published results from large referral centers.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Adrenalectomy / methods. Laparoscopy / methods. Laparoscopy / statistics & numerical data. Pheochromocytoma / surgery
  • [MeSH-minor] Adult. Aged. Cohort Studies. Female. Follow-Up Studies. Humans. Iceland / epidemiology. Immunohistochemistry. Length of Stay. Male. Middle Aged. Minimally Invasive Surgical Procedures / methods. Minimally Invasive Surgical Procedures / statistics & numerical data. Neoplasm Staging. Pain, Postoperative / physiopathology. Postoperative Complications / epidemiology. Probability. Reference Values. Retrospective Studies. Risk Assessment. Treatment Outcome

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  • (PMID = 18163169.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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3. Tavora F, Fajardo DA, Lee TK, Lotan T, Miller JS, Miyamoto H, Epstein JI: Small endoscopic biopsies of the ureter and renal pelvis: pathologic pitfalls. Am J Surg Pathol; 2009 Oct;33(10):1540-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Technical advances in endoscopic equipment have led to increased ureteroscopic biopsies of the upper urinary tract, resulting in limited biopsy material.
  • At consultation, the most common diagnoses were benign urothelium (n=25, 32.9%); atypical (n=17, 22.4%); low-grade noninvasive papillary urothelial carcinoma (n=10, 13.2%); and high-grade noninvasive papillary urothelial carcinoma (n=8, 10.5%).
  • In cases where a definitive diagnosis could not be reached on expert review, it was mainly because of the limited size of the biopsy, absence of papillary fronds, crush artifact, and distorted architecture.
  • There were 7 major discrepancies between the outside and second opinion diagnosis, where all of the cases were initially diagnosed as an urothelial neoplasm, yet was non-neoplastic upon review.
  • Strips of urothelium without well-developed fibrovascular cores, polypoid ureteritis/pyelitis, and reactive urothelium mimicked urothelial neoplasms.
  • In 5 of these 7 cases, there was no gross lesion suspicious of a tumor present according to the urologist.
  • Overall, 33 of the 44 (75%) cases with a mass noted by the urologist or by radiography was found to have a neoplasm at follow-up.
  • Conversely, 24 of the 32 (75%) cases without a grossly suspected tumor had no neoplasm at follow-up.
  • The association between the histologic presence of a neoplasm at follow-up and the presence of a clinically suspected tumor was highly significant (P<0.0001).
  • Pathologists need to recognize that in almost 1 of the 4 renal pelvic/ureteral biopsies a definitive diagnosis cannot be made because of the inadequate tissue.
  • Caution must be exercised in the evaluation of these limited specimens, especially in the absence of a clinically suspected tumor.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy. Endoscopy. Female. Humans. Male. Middle Aged. Urologic Neoplasms / diagnosis

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  • (PMID = 19654502.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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4. Matsushima M, Asakura H, Sakamoto H, Horinaga M, Nakahira Y, Yanaihara H: Leiomyoma of the bladder presenting as acute urinary retention in a female patient: urodynamic analysis of lower urinary tract symptom; a case report. BMC Urol; 2010;10:13
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  • [Title] Leiomyoma of the bladder presenting as acute urinary retention in a female patient: urodynamic analysis of lower urinary tract symptom; a case report.
  • Benign mesenchymal tumors are rare.
  • Leiomyoma of the bladder is the most common benign neoplasm.
  • We present a case of leiomyoma of the bladder presenting with acute urinary retention in a female patient and report on the post-operative change in urodynamic findings.
  • CASE PRESENTATION: A 56-year-old woman presented with acute urinary retention.
  • Evaluations including ultrasound, magnetic resonance imaging, cystoscopy, and urodynamics contributed to a diagnosis of leiomyoma of the bladder.
  • Various medications were ineffective for solving her lower urinary tract symptoms; therefore, a transurethral resection was performed.
  • [MeSH-major] Leiomyoma / complications. Leiomyoma / physiopathology. Urinary Bladder Neoplasms / complications. Urinary Bladder Neoplasms / physiopathology. Urinary Retention / etiology. Urodynamics
  • [MeSH-minor] Female. Humans. Magnetic Resonance Imaging. Manometry. Middle Aged. Treatment Outcome. Urinary Bladder Neck Obstruction / etiology. Urologic Surgical Procedures / methods

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  • (PMID = 20684762.001).
  • [ISSN] 1471-2490
  • [Journal-full-title] BMC urology
  • [ISO-abbreviation] BMC Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2924335
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5. Takao A, Saika T, Uehara S, Monden K, Abarzua F, Nasu Y, Kumon H, Okayama Urological Research Group: Indications for ureteropyeloscopy based on radiographic findings and urine cytology in detection of upper urinary tract carcinoma. Jpn J Clin Oncol; 2010 Nov;40(11):1087-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Indications for ureteropyeloscopy based on radiographic findings and urine cytology in detection of upper urinary tract carcinoma.
  • OBJECTIVE: To verify the indication of diagnostic ureteropyeloscopy based on clinical features for upper urinary tract urothelial cancer with over 100 patients and over a 10-year series.
  • METHODS: From January 1997 to December 2008, consecutive 129 units in 124 patients underwent ureteropyeloscopy to obtain a definitive diagnosis of upper urinary tract cancer or to rule out a malignancy.
  • Patients were divided into four subgroups based on voided urine cytology and preoperative radiographic findings: group A (n = 8), positive urine cytology and positive radiographic findings; group B (n = 4), positive cytology and negative radiographic findings; group C (n = 55), negative cytology and positive radiographic findings and group D (n = 62), gross hematuria originating from the upper urinary tract with negative cytology and negative radiographic findings.
  • Seventy-eight patients out of 80 (97.5%) in groups C and D were confirmed to have benign disease.
  • CONCLUSIONS: Ureteropyeloscopy can help in detecting upper urinary tract cancer or to rule out malignancy for patients with negative voiding cytology.
  • [MeSH-major] Carcinoma, Transitional Cell / diagnosis. Urine / cytology. Urologic Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Sensitivity and Specificity. Survival Rate. Ureteroscopy. Urography. Young Adult

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  • (PMID = 20581003.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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6. Shanks JH, Iczkowski KA: Divergent differentiation in urothelial carcinoma and other bladder cancer subtypes with selected mimics. Histopathology; 2009 Jun;54(7):885-900
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Conventional urothelial carcinoma accounts for most carcinomas of the urinary tract lining.
  • A variety of unusual architectural patterns of urothelial carcinoma, such as the nested, microcystic and inverted variants, can be mistaken for reactive processes or benign tumours.
  • Others such as the micropapillary, plasmacytoid and discohesive variants, can mimic metastatic tumour from other sites.
  • Sarcomatoid carcinoma and its differential diagnosis with other spindle cell lesions of urinary tract will be covered in a separate review.
  • [MeSH-major] Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Clear Cell / diagnosis. Adenocarcinoma, Clear Cell / pathology. Adenoma / diagnosis. Adenoma / pathology. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / pathology. Carcinoma, Transitional Cell / diagnosis. Carcinoma, Transitional Cell / pathology. Cell Differentiation. Cystitis / diagnosis. Cystitis / pathology. Diagnosis, Differential. Giant Cell Tumors / diagnosis. Giant Cell Tumors / pathology. Humans. Neoplasm Metastasis / diagnosis. Neoplasm Metastasis / pathology. Neoplasms, Squamous Cell / diagnosis. Neoplasms, Squamous Cell / pathology. Neuroendocrine Tumors / diagnosis. Neuroendocrine Tumors / pathology. Radiation Injuries / diagnosis. Radiation Injuries / pathology. Urothelium / pathology

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  • (PMID = 19178589.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 152
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7. Montanari E, Del Nero A, Bernardini P, Mangiarotti B, Confalonieri S, Grisotto M, Cordima G: Percutaneous therapy of low stage and grade urothelial neoplasia: long-term follow up. Arch Ital Urol Androl; 2005 Dec;77(4):211-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Percutaneous therapy of low stage and grade urothelial neoplasia: long-term follow up.
  • Nephroureterectomy with the excision of the ipsilateral ureteral orifice and bladder cuff has been considered the standard treatment of the urinary upper transitional cell carcinoma.
  • With the advent of sophisticated techniques for the endo-urologic management of many benign urologic diseases of the upper tract, there has been growing enthusiasm for the application of these same techniques in the management of upper tract TCC, which is also supported by recent advances in the development of small calibre telescopes with improved optics and the development of small calibre adjunctive instruments and laser fibers.
  • A large number of cases published in the literature has confirmed the safety and efficacy of percutaneous treatment in selected patients with upper tract TCC of low grade and stage.
  • 4 pts (5 renal units: 4 T1G2 and 1 TaG1) underwent percutaneous resection for a tumor in a solitary kidney (2 cases), one case for bilateral neoplasm, and in the other case the lesion was unilateral with chronic renal failure.
  • After preoperative evaluation, (excretory urography, computerized tomography and ureteroscopy with biopsy to confirm the low stage and grade of the lesion) the tumor was resected using an Amplatz sheat of 26-30 Fr and a 24 Fr resectoscope to keep a low intra-caliceal pressure.
  • The tumor base was biopsied and fulgurated After 48 h, contrastography to assure integrity of the urinary system was performed and Mitomycin C was infused over 24 h.
  • Second-look nephroscopy with multiple biopsies was performed in all cases 7 days later and 8 Ch nephrostomy was placed.
  • All pts at a mean follow up of 71 months were tumor free.

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  • (PMID = 16444935.001).
  • [ISSN] 1124-3562
  • [Journal-full-title] Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
  • [ISO-abbreviation] Arch Ital Urol Androl
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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8. Cai T, Salvadori A, Nesi G, Detti B, Tinacci G, Zini E, Bartoletti R: Penile metastasis from a T1b prostate carcinoma. Onkologie; 2007 May;30(5):249-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In March 1998, the patient underwent prostate surgery for lower urinary tract symptoms related to benign prostatic obstruction.
  • [MeSH-major] Adenocarcinoma / secondary. Penile Neoplasms / secondary. Prostatic Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / blood. Biopsy. Disease Progression. Humans. Incidental Findings. Male. Neoplasm Staging. Palliative Care. Penis / pathology. Prostate / pathology. Prostate-Specific Antigen / blood. Prostatectomy

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  • (PMID = 17460419.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.21.77 / Prostate-Specific Antigen
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9. Shabbir M, Kirby RS: Fact or fiction: what do the benign prostatic hyperplasia data tell us? Curr Urol Rep; 2005 Jul;6(4):243-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fact or fiction: what do the benign prostatic hyperplasia data tell us?
  • Benign prostatic hyperplasia (BPH) is the most common benign neoplasm in men.
  • We now have a number of medical therapies and minimally invasive treatment options available that can effectively manage lower urinary tract symptoms secondary to benign prostatic obstruction.
  • [MeSH-minor] Algorithms. Animals. Catheter Ablation. Disease Progression. Humans. Laser Coagulation. Male. Prostate / surgery. Quality of Life. Rats. Stents. Transurethral Resection of Prostate. Urinary Retention / etiology. Urodynamics


10. Vemulakonda VM, Kopp RP, Sorensen MD, Grady RW: Recurrent nephrogenic adenoma in a 10-year-old boy with prune belly syndrome : a case presentation. Pediatr Surg Int; 2008 May;24(5):605-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Nephrogenic adenoma is a rare benign lesion of the urinary tract that is associated with a history of irritation or injury of the urothelium.
  • Nephrogenic adenoma commonly presents with lower urinary tract symptoms or hematuria.
  • [MeSH-major] Adenoma / complications. Neoplasm Recurrence, Local / complications. Prune Belly Syndrome / complications. Urinary Bladder Neoplasms / complications

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  • (PMID = 18043925.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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11. Wei JT, Calhoun E, Jacobsen SJ: Urologic diseases in America project: benign prostatic hyperplasia. J Urol; 2005 Apr;173(4):1256-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Urologic diseases in America project: benign prostatic hyperplasia.
  • PURPOSE: Benign prostatic hyperplasia (BPH), the most common benign neoplasm in American men, is a chronic condition that is associated with progressive lower urinary tract symptoms and affects almost 3 of 4 men during the seventh decade of life.
  • RESULTS: In 2000 approximately 4.5 million visits were made to physician offices to for a primary diagnosis of BPH and almost 8 million visits were made with a primary or secondary diagnosis of BPH.

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  • [CommentIn] J Urol. 2005 Apr;173(4):1065-6 [15758702.001]
  • [ReprintIn] J Urol. 2008 May;179(5 Suppl):S75-80 [18405761.001]
  • (PMID = 15758764.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 5-alpha Reductase Inhibitors; 0 / Adrenergic alpha-Antagonists; 0 / Enzyme Inhibitors
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12. Jalpota Y, Tewari V, Madan R: Recurrent nephrogenic adenoma of urinary bladder in a renal allograft recipient--a case report. Indian J Pathol Microbiol; 2006 Apr;49(2):261-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent nephrogenic adenoma of urinary bladder in a renal allograft recipient--a case report.
  • Nephrogenic adenoma is a rare benign tumour-like lesion within the urothelial mucosa of the urinary tract.
  • Clinically it mimics bladder neoplasm.
  • Definite diagnosis is established by histological examination of tumor.
  • Though it attains an extensive spread in bladder mucosa and has a high tendency to recur, the clinical course is benign.
  • [MeSH-major] Adenoma / pathology. Kidney Neoplasms. Neoplasm Recurrence, Local / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans

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  • (PMID = 16933732.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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13. Okada Y, Arakaki R, Kitahara M, Terada N, Kaneko Y, Oomori K, Nishimura K: [Two cases of the nephrogenic adenoma of the bladder]. Hinyokika Kiyo; 2005 Jul;51(7):467-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Nephrogenic adenoma is a relatively rare, benign tumor of the urinary tract.
  • Transurethral resection of the bladder tumor (TUR-Bt) was performed.
  • The second patient was a 72-year-old man who had a history of TUR-Bt for the bladder tumor and a history of left nephroureterectomy for left ureteral tumor.
  • Cystoscopy showed a papillary tumor on the top of the bladder wall and TUR-Bt was performed.
  • In both cases, the histopathological diagnosis was the nephrogenic adenoma.
  • [MeSH-major] Adenoma / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 16119812.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 17
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14. Sung MT, Maclennan GT, Lopez-Beltran A, Montironi R, Cheng L: Natural history of urothelial inverted papilloma. Cancer; 2006 Dec 1;107(11):2622-7
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  • BACKGROUND: Inverted urothelial papilloma is an uncommon urothelial neoplasm.
  • Although it is traditionally regarded as a benign tumor, conflicting data on multiplicity, recurrence rate, and association with urothelial carcinoma have left uncertainties concerning its biologic behavior.
  • METHODS: The authors analyzed the clinicopathological characteristics of 75 cases of inverted papilloma in the urinary tract without prior or concurrent urothelial carcinoma to determine its biologic behavior and prognosis, and to correlate these findings with surveillance strategies.
  • Inverted papillomas were located in the urinary bladder (67 cases), prostatic urethra (4 cases), and ureter (4 cases).
  • All other patients were free of tumor recurrence or progression during a mean follow-up of 68 months (range, 2-240 months).
  • CONCLUSIONS: Both the extremely low incidence of tumor recurrence (1%) and strikingly favorable prognosis suggest that inverted urothelial papilloma, when diagnosed according to strictly defined criteria, is a benign urothelial neoplasm not related to urothelial carcinoma.
  • [MeSH-major] Papilloma, Inverted / pathology. Urologic Neoplasms / pathology

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  • [Copyright] (c) 2006 American Cancer Society.
  • (PMID = 17078053.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Hammarsten J, Damber JE, Peeker R, Mellström D, Högstedt B: A higher prediagnostic insulin level is a prospective risk factor for incident prostate cancer. Cancer Epidemiol; 2010 Oct;34(5):574-9
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  • In the present report, the insulin hypothesis was tested once more prospectively in men with a benign prostatic disorder.
  • Three hundred and eighty-nine consecutive patients referred with lower urinary tract symptoms without clinical prostate cancer were included during 1994-2002.
  • Men with prostate cancer diagnosis had a higher systolic (P<0.001) and diastolic blood pressure (P<0.000), were more obese as measured by BMI (P=0.010), waist (P=0.007) and hip measurements (P=0.041) than men who did not have prostate cancer diagnosis at follow-up.
  • These men also had a higher uric acid level (P=0.040), and a higher fasting serum insulin level (P=0.023) than men who did not have prostate cancer diagnosis at follow-up.
  • [MeSH-major] Insulin / blood. Prostatic Neoplasms / blood
  • [MeSH-minor] Aged. Diabetes Mellitus, Type 2 / blood. Diabetes Mellitus, Type 2 / epidemiology. Humans. Hypertension / blood. Hypertension / epidemiology. Male. Neoplasm Staging. Prospective Studies. Sweden / epidemiology

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20702155.001).
  • [ISSN] 1877-783X
  • [Journal-full-title] Cancer epidemiology
  • [ISO-abbreviation] Cancer Epidemiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Insulin
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16. Wei JT, Calhoun E, Jacobsen SJ: Urologic diseases in america project: benign prostatic hyperplasia. J Urol; 2008 May;179(5 Suppl):S75-80
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  • [Title] Urologic diseases in america project: benign prostatic hyperplasia.
  • PURPOSE: Benign prostatic hyperplasia (BPH), the most common benign neoplasm in American men, is a chronic condition that is associated with progressive lower urinary tract symptoms and affects almost 3 of 4 men during the seventh decade of life.
  • RESULTS: In 2000 approximately 4.5 million visits were made to physician offices to for a primary diagnosis of BPH and almost 8 million visits were made with a primary or secondary diagnosis of BPH.

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  • [CommentIn] J Urol. 2008 May;179(5 Suppl):S81 [18405762.001]
  • [ReprintOf] J Urol. 2005 Apr;173(4):1256-61 [15758764.001]
  • (PMID = 18405761.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / N01 DK012460
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Kanda H, Ishii K, Ogura Y, Imamura T, Kanai M, Arima K, Sugimura Y: Naftopidil, a selective alpha-1 adrenoceptor antagonist, inhibits growth of human prostate cancer cells by G1 cell cycle arrest. Int J Cancer; 2008 Jan 15;122(2):444-51
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  • Alpha-1 adrenoceptor antagonists are generally prescribed for benign prostate hyperplasia with lower urinary tract symptoms.
  • [MeSH-major] Adrenergic alpha-1 Receptor Antagonists. G1 Phase / drug effects. Naphthalenes / pharmacology. Piperazines / pharmacology. Prostatic Neoplasms / drug therapy. Prostatic Neoplasms / metabolism
  • [MeSH-minor] Adrenergic alpha-Antagonists / pharmacology. Animals. Cell Line, Tumor. Cell Proliferation. Cell Separation. Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Cyclin-Dependent Kinase Inhibitor p27. Flow Cytometry. Humans. Intracellular Signaling Peptides and Proteins / metabolism. Male. Mice. Mice, Nude. Neoplasm Transplantation. Receptors, Adrenergic, alpha-1 / metabolism

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  • [Copyright] Copyright 2007 Wiley-Liss, Inc.
  • (PMID = 17918159.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenergic alpha-1 Receptor Antagonists; 0 / Adrenergic alpha-Antagonists; 0 / CDKN1A protein, human; 0 / CDKN1B protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Intracellular Signaling Peptides and Proteins; 0 / Naphthalenes; 0 / Piperazines; 0 / Receptors, Adrenergic, alpha-1; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27; R9PHW59SFN / naftopidil
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18. Stübinger SH, van der Horst Ch, Braun PM: [Pelvic tumors in the eyes of urologists]. Ther Umsch; 2007 Jul;64(7):395-8
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  • [Transliterated title] Raumforderungen im kleinen Becken aus Sicht des Urologen.
  • Pelvic tumors originating from outside the urinary tract commonly invade the urogenital organs by direct extension mainly because of the close relationships between the pelvic organs.
  • Benign tumors such as endometrial myoma, ovarian cyst and adenoma of the colon might lead to the development of urogenital symptoms.
  • These are the symptoms that lead to the diagnosis of the primary tumor.
  • It has to be kept in mind that urogenital tumors with such symptoms have to be included in the differential diagnosis.
  • An example is the development of hydronephrosis, where the initial measure has to be the immediate relief of the obstruction through draining of either the kidney or the urinary bladder.
  • The possibility of eradicating the tumor is then to be discussed after relieving the obstruction.
  • [MeSH-major] Pelvic Neoplasms. Prostatic Hyperplasia. Prostatic Neoplasms. Urethral Neoplasms. Urinary Bladder Neoplasms
  • [MeSH-minor] Cystectomy. Cystoscopy. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Neoplasm Staging. Prostatectomy. Quality of Life. Urinary Bladder / pathology

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  • (PMID = 17948757.001).
  • [ISSN] 0040-5930
  • [Journal-full-title] Therapeutische Umschau. Revue thérapeutique
  • [ISO-abbreviation] Ther Umsch
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Switzerland
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19. Zachariou AG, Manoliadis IN, Kalogianni PA, Karagiannis GK, Georgantzis DJ: A rare case of bladder fibroepithelial polyp in childhood. Arch Ital Urol Androl; 2005 Jun;77(2):118-20
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  • OBJECTIVE: To present a rare case of a benign polyp in a child.
  • Very few cases of urinary tract fibroepithelial polyps in the bladder are reported in the international literature and they are even less common in children.
  • The patient did not report previous urinary tract disorders.
  • After a thorough laboratory investigation, which included urinalysis, urine culture, ultrasonography, intravenous pyelography and cystoscopy the presence of an exophytic papillary tumor in the bladder was identified.
  • RESULTS: The biopsy set the diagnosis of fibroepithelial polyp, which is a rare benign neoplasm and occurs in patients of nearly all ages.

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  • (PMID = 16146277.001).
  • [ISSN] 1124-3562
  • [Journal-full-title] Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
  • [ISO-abbreviation] Arch Ital Urol Androl
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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20. Antonelli A, Zani D, Dotti P, Tralce L, Simeone C, Cunico SC: Use of the appendix as ureteral substitute in a patient with a single kidney affected by relapsing upper urinary tract carcinoma. ScientificWorldJournal; 2005 Apr 5;5:276-9
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  • [Title] Use of the appendix as ureteral substitute in a patient with a single kidney affected by relapsing upper urinary tract carcinoma.
  • The treatment of upper urinary tract transitional cell carcinoma (UT-TCC) in single-kidney patients requires the radical removal of cancer, but also, when feasible, the preservation of the continuity of the urinary tract by various surgical techniques.
  • In the literature, the cecal appendix has rarely been used as a ureteral substitute, moreover in benign pathological conditions, showing encouraging early results.
  • [MeSH-major] Appendix / transplantation. Carcinoma, Transitional Cell / surgery. Neoplasm Recurrence, Local / surgery. Ureter / surgery. Ureteral Neoplasms / surgery

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  • (PMID = 15962193.001).
  • [ISSN] 1537-744X
  • [Journal-full-title] TheScientificWorldJournal
  • [ISO-abbreviation] ScientificWorldJournal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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21. Ho H, Chen YD, Tan PH, Wang M, Lau WK, Cheng C: Inverted papilloma of urinary bladder: is long-term cystoscopic surveillance needed? A single center's experience. Urology; 2006 Aug;68(2):333-6
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  • [Title] Inverted papilloma of urinary bladder: is long-term cystoscopic surveillance needed? A single center's experience.
  • OBJECTIVES: To review all cases of urinary bladder inverted papilloma (IP) in our institution and determine the need for cystoscopic surveillance.
  • IP is an uncommon benign tumor of the urinary tract.
  • No patient had a synchronous or previous bladder tumor.
  • CONCLUSIONS: Although our cases exhibited benign biologic behavior, the presence of cytologic atypia and suspicious urine cytology require exclusion of TCC with an inverted pattern.
  • [MeSH-major] Cystoscopy. Papilloma, Inverted / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 16904447.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Srivastava S, Roy R, Singh S, Kumar P, Dalela D, Sankhwar SN, Goel A, Sonkar AA: Taurine - a possible fingerprint biomarker in non-muscle invasive bladder cancer: A pilot study by 1H NMR spectroscopy. Cancer Biomark; 2010;6(1):11-20
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  • Urinary bladder cancer is a major epidemiological problem that continues to grow each year.
  • In this pilot study, utility of non-invasive (1)H NMR spectroscopy has been evaluated for probing the metabolic perturbations occurring in non-muscle invasive urinary bladder cancer. (1)H NMR spectra of urine of bladder cancer patients and controls (healthy and urinary tract infection/bladder stone) (n = 103) were acquired at 400MHz.
  • The cancer patients showed significant (p < 0.05) variations in concentration of hippurate and citrate as compared with healthy controls and benign controls.
  • [MeSH-major] Biomarkers, Tumor / urine. Early Detection of Cancer / methods. Magnetic Resonance Spectroscopy / methods. Taurine / urine. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Carcinoma in Situ / diagnosis. Carcinoma in Situ / metabolism. Humans. Male. Middle Aged. Neoplasm Staging. Pilot Projects. Protons. Sensitivity and Specificity. Young Adult

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  • (PMID = 20164538.001).
  • [ISSN] 1875-8592
  • [Journal-full-title] Cancer biomarkers : section A of Disease markers
  • [ISO-abbreviation] Cancer Biomark
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Protons; 1EQV5MLY3D / Taurine
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23. Lee SH, Mah SY, Chung BH: Incidentally discovered inverted papilloma of the urinary bladder in patients with lower urinary tract symptoms. J Endourol; 2010 Feb;24(2):271-5
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  • [Title] Incidentally discovered inverted papilloma of the urinary bladder in patients with lower urinary tract symptoms.
  • BACKGROUND AND PURPOSE: Inverted urothelial papilloma (IP) is an uncommon urothelial neoplasm.
  • We aimed to determine the clinicopathologic characteristics of IP of the bladder and its association with prostate volume and lower urinary tract symptoms (LUTS).
  • PATIENTS AND METHODS: From 1994 to 2008, 53 patients with urinary IP underwent transurethral resection of the bladder tumor (TURBT) at our institution.
  • In IP located on the bladder neck of patients with benign prostatic hyperplasia (BPH), significantly higher obstructive symptoms and larger prostate volumes than that of other located IP with BPH were observed.
  • CONCLUSIONS: This is the largest series of cases of urinary bladder IP reported from Korea.
  • Despite the absence of agreement of its etiology, its presenting symptoms were related to LUTS and benign prostatic enlargement.

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  • (PMID = 20039831.001).
  • [ISSN] 1557-900X
  • [Journal-full-title] Journal of endourology
  • [ISO-abbreviation] J. Endourol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Crook TJ, Mead Z, Vadgama B, Malone PS: A case series of nephrogenic adenoma of the urethra and bladder in children: review of this rare diagnosis, its natural history and management, with reference to the literature. J Pediatr Urol; 2006 Aug;2(4):323-8
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  • [Title] A case series of nephrogenic adenoma of the urethra and bladder in children: review of this rare diagnosis, its natural history and management, with reference to the literature.
  • Nephrogenic adenoma (NA) is a rare benign tumour of the urinary tract and is found most commonly in the bladder.
  • Their diagnostic and management features in the context of differential diagnosis and natural history are discussed.
  • A 3-year-old girl presented with recurrent urinary tract infections (UTIs) and haematuria.
  • An ultrasound scan suggested a large bladder tumour, which was biopsied cystoscopically, and histology confirmed an NA.
  • She then underwent open resection of the tumour.
  • A cystoscopy showed a papillary tumour, which was confirmed as NA on histology.

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  • (PMID = 18947630.001).
  • [ISSN] 1873-4898
  • [Journal-full-title] Journal of pediatric urology
  • [ISO-abbreviation] J Pediatr Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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25. Ko ML, Lin HW, Chen SC, Pan HS: Should cystoscopy be routinely performed after laparoscopy-assisted vaginal hysterectomy? Minim Invasive Ther Allied Technol; 2008;17(3):195-9
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  • There were eighty patients who underwent LAVH for benign tumors of the uterus (adenomyosis and myoma), uterine prolapse, persistent intraepithelial neoplasm of the cervix (CIN3) and cervical carcinoma in situ (CIS).
  • Intra-operative cystoscopy with ureteral stenting was performed at the time of LAVH to evaluate the urinary tract.
  • Urinary tract evaluation, including cystoscopy and ureteral stenting at the time of complex gynecologic surgery such as LAVH could be incorporated in the whole surgical procedure.
  • [MeSH-major] Cystoscopy / methods. Hysterectomy, Vaginal / adverse effects. Intraoperative Complications / diagnosis. Laparoscopy / adverse effects
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Hematuria / etiology. Humans. Middle Aged. Postoperative Complications / prevention & control. Retrospective Studies. Stents. Ureter / injuries. Ureter / surgery. Ureteral Obstruction / diagnosis. Ureteral Obstruction / etiology. Ureteral Obstruction / surgery

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  • (PMID = 18608998.001).
  • [ISSN] 1365-2931
  • [Journal-full-title] Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy
  • [ISO-abbreviation] Minim Invasive Ther Allied Technol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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26. Chitale S, Mbakada R, Irving S, Burgess N: Nephroureterectomy for transitional cell carcinoma - the value of pre-operative histology. Ann R Coll Surg Engl; 2008 Jan;90(1):45-50
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  • INTRODUCTION: Nephroureterectomy with excision of a cuff of bladder remains the standard for managing upper tract transitional cell carcinoma (TCC).
  • Increasing use of diagnostic upper tract endoscopy has underlined the importance of obtaining a pre-operative histological diagnosis in order to avoid under-treating high-grade or multifocal disease and over-treating low-grade disease, which could, in selected cases, be managed conservatively.
  • We review nephroureterectomy at our institution over a 10-year period with particular reference to a pre-operative histological diagnosis.
  • Of these cases, 58 were for upper tract TCC and 50 of these 58 had intravenous urography (IVU): 9 had only IVU, 28 had an additional CT scan, 5 had an additional ultrasonography and 8 had additional CT + ultrasonography for pre-operative work-up.
  • Thirty-one (53%) of the 58 tumours were within the pelvicalyceal system and 27 within the ureter (upper, 5; middle, 3; lower, 19).
  • RESULTS: Nineteen (32.7%) of the 58 patients had a pre-operative histological diagnosis - 17 G2pTa, 1 G1pTa, and 1 G2pT1.
  • Five (12.8%) of 39 patients without pre-operative histology had no TCC in the final surgical specimen: 4 (10.25%) had benign pathology such as capillary haemangioma, urothelial cysts and reactive urothelial changes while one had renal cell carcinoma (RCC).
  • CONCLUSIONS: This study underlines the importance of obtaining a pre-operative histological diagnosis in cases with presumed upper tract TCC.
  • Failure to do so can result in unnecessary ablative surgery for benign disease.
  • Such an approach can also help identify multifocality and grade of disease so that treatment of upper tract TCC can be tailored more appropriately with ablative surgery for high-grade or multifocal disease and conservative (endoscopic) therapy for low-grade disease in selected cases.
  • Patients with suspected TCC of the upper tract should be managed at centres where facilities for the comprehensive evaluation of such tumours exist.
  • [MeSH-major] Carcinoma, Transitional Cell / surgery. Nephrectomy / methods. Preoperative Care / methods. Ureter / surgery. Ureteral Neoplasms / surgery
  • [MeSH-minor] Aged. Female. Flank Pain / etiology. Hematuria / etiology. Histological Techniques / methods. Humans. Male. Neoplasm Recurrence, Local / etiology. Treatment Outcome. Urinary Bladder Neoplasms / etiology

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  • (PMID = 18201500.001).
  • [ISSN] 1478-7083
  • [Journal-full-title] Annals of the Royal College of Surgeons of England
  • [ISO-abbreviation] Ann R Coll Surg Engl
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2216716
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27. Ye B, Skates S, Mok SC, Horick NK, Rosenberg HF, Vitonis A, Edwards D, Sluss P, Han WK, Berkowitz RS, Cramer DW: Proteomic-based discovery and characterization of glycosylated eosinophil-derived neurotoxin and COOH-terminal osteopontin fragments for ovarian cancer in urine. Clin Cancer Res; 2006 Jan 15;12(2):432-41
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  • EXPERIMENTAL DESIGN: Urine samples collected preoperatively from postmenopausal women with ovarian cancer and benign conditions and from nonsurgical controls were analyzed by surface-enhanced laser desorption/ionization mass spectrometry and two-dimensional gel electrophoresis.
  • Quantitative and semiquantitative ELISAs were developed for preliminary validation in patients of 128 ovarian cancer, 52 benign conditions, 44 other cancers, and 188 healthy controls.
  • RESULTS: A protein (m/z approximately 17,400) with higher peak intensities in cancer patients than in benign conditions and controls was identified and subsequently defined as eosinophil-derived neurotoxin (EDN).
  • CONCLUSIONS: Specific elevated posttranslationally modified urinary EDN and osteopontin COOH-terminal fragments in ovarian cancer might lead to potential noninvasive screening tests for early diagnosis.
  • Urine with less complexity than serum and relatively high thermodynamic stability of peptides or metabolites is a promising study medium for discovery of the novel biomarkers which may present in many non-urinary tract neoplastic diseases.
  • [MeSH-major] Biomarkers, Tumor / urine. Eosinophil-Derived Neurotoxin / urine. Neoplasms, Glandular and Epithelial / urine. Ovarian Neoplasms / urine. Sialoglycoproteins / urine
  • [MeSH-minor] Adenocarcinoma, Clear Cell / pathology. Adenocarcinoma, Clear Cell / surgery. Adenocarcinoma, Clear Cell / urine. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / surgery. Adenocarcinoma, Mucinous / urine. Amino Acid Sequence. Carcinoma, Endometrioid / pathology. Carcinoma, Endometrioid / surgery. Carcinoma, Endometrioid / urine. Case-Control Studies. Cystadenocarcinoma, Serous / pathology. Cystadenocarcinoma, Serous / surgery. Cystadenocarcinoma, Serous / urine. Electrophoresis, Gel, Two-Dimensional. Enzyme-Linked Immunosorbent Assay. Female. Glycosylation. Humans. Molecular Sequence Data. Neoplasm Invasiveness. Osteopontin. Prognosis. Proteome. Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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  • [CommentIn] Clin Cancer Res. 2006 Jan 15;12(2):323-7 [16428467.001]
  • (PMID = 16428483.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 1P50 CA 105009; United States / NCI NIH HHS / CA / R21 CA 111949-01; United States / NCI NIH HHS / CA / U01 CA 86381
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Proteome; 0 / SPP1 protein, human; 0 / Sialoglycoproteins; 106441-73-0 / Osteopontin; EC 3.1.- / Eosinophil-Derived Neurotoxin
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28. Lowe MP, Chamberlain DH, Kamelle SA, Johnson PR, Tillmanns TD: A multi-institutional experience with robotic-assisted radical hysterectomy for early stage cervical cancer. Gynecol Oncol; 2009 May;113(2):191-4
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  • METHODS: A multi-institutional robotic surgical consortium consisting of five board-certified gynecologist oncologist in distinct geographical regions of the United States was created to evaluate the utility of robotics for gynecologic surgery (benign and malignant).
  • Between April 2003 and August 2008, a total of 835 patients underwent robotic surgery for benign gynecologic disorders and/or gynecologic malignancies by a surgeon in the consortium.
  • Postoperative complications were reported in 12% of the patients and included a DVT (2.4%), infection (7.2%), and bladder/urinary tract complication (2.4%) The conversion rate to laparotomy was 2.4%.
  • [MeSH-major] Uterine Cervical Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Hysterectomy. Laparoscopy. Neoplasm Staging. Retrospective Studies. Robotics. Treatment Outcome


29. Huszar M, Moldenhauer G, Gschwend V, Ben-Arie A, Altevogt P, Fogel M: Expression profile analysis in multiple human tumors identifies L1 (CD171) as a molecular marker for differential diagnosis and targeted therapy. Hum Pathol; 2006 Aug;37(8):1000-8
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  • [Title] Expression profile analysis in multiple human tumors identifies L1 (CD171) as a molecular marker for differential diagnosis and targeted therapy.
  • Here we carried out an immunohistochemical survey of L1 expression in normal adults and in a broad range of benign and malignant tumors using monoclonal antibody L1-11A and the novel monoclonal antibody L1-14.10.
  • In tumors of the female genital tract, L1 was detected in adenocarcinomas of the cervix and fallopian tubes, in addition to ovarian and endometrial carcinomas.
  • Nongynecological tumors expressing L1 comprised malignant melanoma, colon adenocarcinoma positive to chromogranin, clear-cell adenocarcinoma of the urinary bladder, pheochromocytoma, small cell lung carcinoma, and tumors of the nervous system.
  • L1 was absent in breast carcinoma, gastrointestinal tract carcinomas, gastrointestinal carcinoids, renal clear-cell carcinomas, prostate adenocarcinomas, and mesotheliomas.
  • Our results suggest that L1 expression in tumors is not ubiquitous but restricted to certain subtypes and may be a helpful molecular marker for differential diagnosis and target for antibody-based therapy.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Biomarkers, Tumor / metabolism. Genital Neoplasms, Female / metabolism. Isoantigens / metabolism. Membrane Glycoproteins / metabolism. Receptors, Cell Surface / metabolism
  • [MeSH-minor] Antibodies, Monoclonal / immunology. Cell Line, Tumor. Diagnosis, Differential. Female. Fluorescent Antibody Technique, Direct. GPI-Linked Proteins. Humans. Immunoenzyme Techniques. Male. Neutrophils / metabolism

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  • (PMID = 16867862.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / CD177 protein, human; 0 / GPI-Linked Proteins; 0 / Isoantigens; 0 / Membrane Glycoproteins; 0 / Receptors, Cell Surface
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30. Reich O, Gratzke C, Bachmann A, Seitz M, Schlenker B, Hermanek P, Lack N, Stief CG, Urology Section of the Bavarian Working Group for Quality Assurance: Morbidity, mortality and early outcome of transurethral resection of the prostate: a prospective multicenter evaluation of 10,654 patients. J Urol; 2008 Jul;180(1):246-9
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  • PURPOSE: Transurethral resection of the prostate has for decades been the standard surgical therapy for lower urinary tract symptoms secondary to benign prostatic hyperplasia, the most common benign neoplasm in men.
  • The most relevant complications were failure to void (5.8%), surgical revision (5.6%), significant urinary tract infection (3.6%), bleeding requiring transfusions (2.9%) and transurethral resection syndrome (1.4%).
  • Urinary peak flow rate increased significantly to 21.6 +/- 9.4 ml per second (baseline 10.4 +/- 6.8 ml per second, 1 tail p <0.0001), while post-void residual decreased to 31.1 +/- 73.0 ml (baseline 180.3 +/- 296.9 ml, 1-tail p <0.0001).
  • This most contemporary information should be of use to potential patients and facilitate subsumption of emerging surgical and nonsurgical benign prostatic hyperplasia treatment options.

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  • [CommentIn] J Urol. 2008 Jul;180(1):15-6 [18485411.001]
  • (PMID = 18499179.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Investigator] Altwein J; Hartung R; Klotz T; Kriegmair M; Liedl B; Ottmann K; Burmeister C
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31. Garrido Abad P, Coloma del Peso A, Jiménez Gálvez M, Herranz Fernández LM, Arellano Gañán R, Reina Durán T: [Inflammatory myofibroblastic tumor. Case report]. Arch Esp Urol; 2008 Jan-Feb;61(1):62-5
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  • [Title] [Inflammatory myofibroblastic tumor. Case report].
  • [Transliterated title] Tumor miofibroblástico inflamatorio vesical. Aportación de un nuevo caso.
  • OBJECTIVE: To report one case of myofibroblastic bladder tumor.
  • METHODS/RESULTS: We report the case of a 30-year-old woman with recurrent urinary tract infections and incidental finding of a bladder mass after abdominal ultrasound.
  • After TUR, inflammatory myofibroblastic tumor of the bladder was diagnosed.
  • CONCLUSION: Myofibroblastic tumor (also known as inflammatory pseudotumor or pseudosarcoma) is a benign tumor with mesenchymal origin.
  • It must not be misdiagnosed as a malignant neoplasm.
  • [MeSH-major] Leydig Cell Tumor / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 18405029.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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32. Chen CS, Cheng CL: Nephrogenic adenoma of the urinary bladder: clinical experience and review of the literature. J Chin Med Assoc; 2006 Apr;69(4):166-8
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  • [Title] Nephrogenic adenoma of the urinary bladder: clinical experience and review of the literature.
  • BACKGROUND: Nephrogenic adenoma (NA) is a rare disease of the urinary tract.
  • We report our clinical experience with this disease in the urinary bladder and review the literature.
  • METHODS: Between April 1994 and July 2004, 8 patients were diagnosed with NA of the urinary bladder: 3 men and 5 women, aged 23-77 years (mean 49.6).
  • All patients had recurrent urinary tract infection.
  • Urinary tuberculosis was diagnosed in 2 patients.
  • Previous long-term urinary catheterization was noted in 3 patients.
  • Urinary frequency and microscopic hematuria were found in all patients.
  • CONCLUSION: NA is an uncommon benign metaplastic lesion occurring in the urothelium.
  • Transurethral resection of NA provides a definite diagnosis and relief of symptoms.
  • [MeSH-major] Adenoma / etiology. Urinary Bladder Neoplasms / etiology
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 16689198.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China (Republic : 1949- )
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33. Kunju LP: Nephrogenic adenoma: report of a case and review of morphologic mimics. Arch Pathol Lab Med; 2010 Oct;134(10):1455-9
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  • Nephrogenic adenoma, also referred to as nephrogenic metaplasia, is an uncommon benign lesion of the urothelial tract, characterized by a circumscribed proliferation of tubules, cysts, and papillae lined by cells with low cuboidal to columnar epithelium.
  • The diagnostic features that are useful in the recognition of this benign entity are the characteristic mixture of various architectural patterns, associated stromal edema and inflammation, hyaline sheath around tubules, eosinophilic colloidlike secretion within tubules, and lack of mitotic activity.
  • [MeSH-major] Adenoma / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Child. Diagnosis, Differential. Female. Humans. Male. Neoplasm Invasiveness. Prostate-Specific Antigen / blood. Sex Ratio. Urethra / pathology. Urothelium / pathology

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  • (PMID = 20923300.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen
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34. Gopalan A, Sharp DS, Fine SW, Tickoo SK, Herr HW, Reuter VE, Olgac S: Urachal carcinoma: a clinicopathologic analysis of 24 cases with outcome correlation. Am J Surg Pathol; 2009 May;33(5):659-68
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  • RESULT: The mean age at diagnosis was 52 years (range: 26 to 68 y).
  • In all instances but 1, cystitis cystica/glandularis was focal and predominantly in the bladder overlying the urachal neoplasm.
  • Urachal remnants were identified in 15 cases: the urachal epithelium was benign urothelial-type in 6 cases and showed adenomatous changes in 9.
  • In all 3, urachal remnants were identified and showed transition from benign to adenomatous epithelium.
  • The mean follow-up period was 40 months (range: 0.3 to 157.6 mo).
  • Surface urothelial involvement by carcinoma and presence of cystitis cystica/glandularis do not necessarily exclude the diagnosis of urachal carcinoma.
  • Immunostains do not unequivocally discriminate a urachal from a colorectal carcinoma, but diffuse positivity for 34BE12 would support, and diffuse nuclear immunoreactivity for beta-catenin would militate against, a diagnosis of urachal carcinoma.
  • Local recurrence may be owing to seeding within the distal urothelial tract, particularly in tumors with a configuration that is polypoid and which open into the bladder cavity.
  • [MeSH-major] Carcinoma / pathology. Urachus / pathology. Urinary Bladder Neoplasms / pathology. Urothelium / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Carcinoma, Signet Ring Cell / pathology. Chemotherapy, Adjuvant. Cystectomy. Cystitis / pathology. Databases as Topic. Female. Homeodomain Proteins / analysis. Humans. Immunohistochemistry. Keratin-20 / analysis. Keratin-7 / analysis. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local. Neoplasm Staging. Radiotherapy, Adjuvant. Treatment Outcome. Umbilicus / surgery. beta Catenin / analysis

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  • (PMID = 19252435.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / T32 CA082088
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDX2 protein, human; 0 / CTNNB1 protein, human; 0 / Homeodomain Proteins; 0 / KRT20 protein, human; 0 / KRT7 protein, human; 0 / Keratin-20; 0 / Keratin-7; 0 / beta Catenin
  • [Other-IDs] NLM/ NIHMS627175; NLM/ PMC4225778
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35. Wang J, Wang H, Tang G, Hou Z, Wang G: Transitional cell carcinoma of upper urinary tract vs. benign lesions: distinctive MSCT features. Abdom Imaging; 2009 Jan-Feb;34(1):94-106
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  • [Title] Transitional cell carcinoma of upper urinary tract vs. benign lesions: distinctive MSCT features.
  • The transitional cell carcinoma (TCC) of the upper urinary tract is relatively uncommon.
  • The clinical presentation of TCCs and many other diseases of the upper urinary tract are nonspecific, and most of these lesions are usually necessary to be evaluated by computed tomography (CT) urography.
  • CT appearances of TCCs can be classified as papillary, infiltrating papillary, and diffusely infiltrating tumor.
  • Most TCCs of the upper urinary tract can be identified on the bases of characteristic CT appearances.
  • However, some benign lesions may mimic different categories of TCCs and should be taken into account for differentiating diagnosis.
  • The useful CT signs to make differential diagnosis involve enhanced pattern, location of lesion, induration of urinary tract, and range of thickening of urinary wall.
  • The three-dimension (3D) reconstructed images is useful in making differential diagnosis.
  • [MeSH-major] Carcinoma, Transitional Cell / radiography. Tomography, Spiral Computed / methods. Urologic Neoplasms / radiography
  • [MeSH-minor] Adult. Aged. Contrast Media. Diagnosis, Differential. Humans. Imaging, Three-Dimensional. Infant. Male. Middle Aged. Neoplasm Staging. Radiographic Image Interpretation, Computer-Assisted

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  • (PMID = 18581162.001).
  • [ISSN] 1432-0509
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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36. Cheng L, Foster SR, MacLennan GT, Lopez-Beltran A, Zhang S, Montironi R: Inflammatory myofibroblastic tumors of the genitourinary tract--single entity or continuum? J Urol; 2008 Oct;180(4):1235-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Inflammatory myofibroblastic tumors of the genitourinary tract--single entity or continuum?
  • PURPOSE: Inflammatory myofibroblastic tumor of the genitourinary tract is a spindled soft tissue lesion that is often mistaken for sarcoma.
  • The relationship between inflammatory myofibroblastic tumor and other morphologically similar entities has been a long-standing source of controversy.
  • We investigated whether inflammatory myofibroblastic tumors in adults and children are the same entity, and whether inflammatory myofibroblastic tumor is part of a biological spectrum that includes benign and malignant entities at opposite ends.
  • CONCLUSIONS: Inflammatory myofibroblastic tumor of the genitourinary tract should be considered a neoplasm of uncertain malignant potential, and routine surveillance and close clinical followup are recommended.
  • Aggressive therapy (radical cystectomy, radiation or chemotherapy) is unwarranted given the indolent and often benign clinical course for the majority of cases.
  • [MeSH-major] Carcinoma / pathology. Granuloma, Plasma Cell / pathology. Sarcoma / pathology. Urogenital Neoplasms / pathology
  • [MeSH-minor] Biopsy, Needle. Diagnosis, Differential. Humans. Immunohistochemistry. Incidence. Neoplasm Staging. Prognosis. Risk Assessment. Ureteral Neoplasms / diagnosis. Ureteral Neoplasms / pathology. Urethral Neoplasms / diagnosis. Urethral Neoplasms / pathology. Urinary Bladder Neoplasms / diagnosis. Urinary Bladder Neoplasms / pathology

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  • (PMID = 18707729.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 40
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37. Eiber M, van Oers JM, Zwarthoff EC, van der Kwast TH, Ulrich O, Helpap B, Stoerkel S, Blaszyk H, Cheville J, Sauter G, Wild PJ, Stoehr R, Hofstaedter F, Hartmann A: Low frequency of molecular changes and tumor recurrence in inverted papillomas of the urinary tract. Am J Surg Pathol; 2007 Jun;31(6):938-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Low frequency of molecular changes and tumor recurrence in inverted papillomas of the urinary tract.
  • AIM: Inverted papilloma (IP) of the urinary tract can be difficult to distinguish from noninvasive urothelial carcinoma with prominent inverted growth pattern (invNIUC).
  • CONCLUSIONS: IP is a benign lesion that lacks specific genetic alterations found in exophytic noninvasive papillary urothelial tumors.
  • [MeSH-major] Neoplasm Recurrence, Local / pathology. Papilloma, Inverted / genetics. Papilloma, Inverted / pathology. Urologic Neoplasms / genetics. Urologic Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Carcinoma / pathology. DNA Mutational Analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Loss of Heterozygosity. Microsatellite Repeats. Middle Aged. Observer Variation. Polymerase Chain Reaction. Receptor, Fibroblast Growth Factor, Type 3 / genetics

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  • (PMID = 17527084.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / FGFR3 protein, human; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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38. Lane Z, Epstein JI: Polypoid/papillary cystitis: a series of 41 cases misdiagnosed as papillary urothelial neoplasia. Am J Surg Pathol; 2008 May;32(5):758-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Polypoid/papillary cystitis: a series of 41 cases misdiagnosed as papillary urothelial neoplasia.
  • Polypoid cystitis and its more chronic phase papillary cystitis, which results as a reaction to injury to the bladder mucosa, is a benign lesion mimicking various papillary urothelial neoplasms.
  • Analogous lesions occur throughout the urothelial tract and are referred to as polypoid urethritis, polypoid ureteritis, and polypoid pyelititis when present in the urethra, ureter, and renal pelvis, respectively.
  • Of 155 cases diagnosed as polypoid cystitis, we identified 41 cases that were diagnosed as papillary urothelial neoplasms by contributing pathologists and only sent to us, typically at the request of the urologist after the case had be signed out.
  • For cases where information was available, clinical symptoms included bladder obstruction (n=7), gross hematuria (n=6), colovesicular fistula (n=4), follow-up status posttreatment of bladder and ureter carcinoma (n=4), bladder/urethral stones (n=2), benign prostate hyperplasia (n=2), follow-up after radiation for prostate cancer (n=2), long-standing urinary stents (n=2), and voiding dysfunction (n=1).
  • Original diagnoses included noninvasive low grade papillary urothelial carcinoma (n=23), noninvasive high grade papillary urothelial carcinoma (n=6), papillary urothelial neoplasm of low malignant potential (n=5), papilloma (n=3), urothelial neoplasia (n=2), carcinoma in situ (n=1), and squamous carcinoma (n=1).
  • The mean age at diagnosis was 63 years (range, 19 to 93 y; median 63 y).
  • Clinical symptoms varied with the most common manifestations, including gross hematuria, bladder/urethral stones, history of prostate cancer treated with radiation, follow-up after bladder/ureter carcinoma treatment, long-term urinary stents, and colovesicular fistulas.
  • The key to correctly diagnosing polypoid/papillary cystitis is to recognize at low magnification the reactive nature of the process with an inflamed background that is edematous or densely fibrous with predominantly simple, non-branching, broad-based fronds of relatively normal thickness urothelium, and not focus at higher power on the exceptional frond that may more closely resemble a urothelial neoplasm either architecturally or cytologically.
  • In cases where the diagnosis of papillary neoplasia is not straightforward and there is a question of polypoid cystitis, pathologists should seek clinical history that might suggest a reactive process.
  • Because the urologist can more often better recognize the inflammatory nature of the lesion than the pathologist, the pathologist should hesitate diagnosing urothelial neoplasia when the cystoscopic impression is that of an inflammatory lesion.
  • [MeSH-major] Carcinoma, Papillary / diagnosis. Cystitis / diagnosis. Polyps / diagnosis. Urologic Neoplasms / diagnosis. Urothelium / pathology

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  • (PMID = 18379418.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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39. Tiwari P, Tripathi A, Vijay M, Mitra B, Kumar S, Pal DK, Kundu AK: Inverted papilloma of the urinary bladder: Rigorous surveillance needed? An Indian experience. Indian J Cancer; 2010 Oct-Dec;47(4):418-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Inverted papilloma of the urinary bladder: Rigorous surveillance needed? An Indian experience.
  • AIMS: Inverted papilloma (IP) is an uncommon benign neoplasm of the urinary tract.
  • In this study, we review all cases of urinary bladder IP in our institution and determine the need for strict follow-up.
  • MATERIALS AND METHODS: We included consecutive patients from August 2004 to August 2008 with IP of the urinary bladder in this study who did not have prior or concurrent urothelial carcinoma.
  • No patient had a synchronous or previous bladder tumor.
  • CONCLUSIONS: We conclude that when diagnosed by strictly defined criteria, IP as benign urothelial neoplasm was with extremely low incidence of recurrence and good prognosis.
  • [MeSH-major] Papilloma, Inverted / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 21131756.001).
  • [ISSN] 1998-4774
  • [Journal-full-title] Indian journal of cancer
  • [ISO-abbreviation] Indian J Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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