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1. Sakuma T, Ohashi H, Kawano K: Nodular hidradenoma masquerading an epidermal cyst. J Eur Acad Dermatol Venereol; 2008 Jul;22(7):900-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nodular hidradenoma masquerading an epidermal cyst.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Epidermal Cyst / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 18070023.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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2. Deprez M, Uffer S: Clinicopathological features of eyelid skin tumors. A retrospective study of 5504 cases and review of literature. Am J Dermatopathol; 2009 May;31(3):256-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Eyelid tumors are the most common neoplasm in daily ophthalmology practice and encompass a wide variety of benign and malignant tumors.
  • Benign tumors largely predominated over malignant ones, representing 84% of cases in this series, and the 5 most frequent subtypes were squamous cell papilloma (26%), seborrheic keratosis (21%), melanocytic nevus (20%), hidrocystoma (8%), and xanthoma/xanthelasma (6%).
  • Basal cell carcinoma was the most frequent malignant tumor (86%), followed by squamous cell carcinoma (7%) and sebaceous carcinoma (3%).
  • For several tumor subtypes, there was a poor correlation between clinical and histological diagnosis, stressing the numerous pitfalls in the diagnosis of eyelid tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Child. Child, Preschool. Female. Hidrocystoma / pathology. Humans. Infant. Keratosis, Seborrheic / pathology. Male. Middle Aged. Nevus, Pigmented / pathology. Papilloma / pathology. Predictive Value of Tests. Retrospective Studies. Sebaceous Gland Neoplasms / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology. Xanthomatosis / pathology. Young Adult

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  • (PMID = 19384066.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 32
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3. Barbarino S, McCormick SA, Lauer SA, Milman T: Syringocystadenoma papilliferum of the eyelid. Ophthal Plast Reconstr Surg; 2009 May-Jun;25(3):185-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: To describe 6 patients with syringocystadenoma papilliferum of the eyelid and to review the literature regarding this rare eyelid tumor.
  • None of the lesions was associated with a malignant neoplasm.
  • Although syringocystadenoma papilliferum of the eyelid can be associated with other benign lesions, no malignant transformation or association with malignant neoplasms has been reported.
  • The evidence suggests that this tumor should be managed with conservative complete excision.
  • [MeSH-major] Cystadenoma / pathology. Eyelid Neoplasms / pathology. Sweat Gland Neoplasms / pathology. Syringoma / pathology

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  • (PMID = 19454927.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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4. Gupta R, Singh S, Gupta K, Kudesia M: Clear-cell hidradenoma in a child: a diagnostic dilemma for the cytopathologist. Diagn Cytopathol; 2009 Jul;37(7):531-3
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  • [Title] Clear-cell hidradenoma in a child: a diagnostic dilemma for the cytopathologist.
  • As a result, the cytological reports of skin adnexal tumors like hidradenoma are scarce in the available literature.
  • The cytological features, in conjunction with the clinical examination, suggested a skin appendageal tumor.
  • Though nuclear pleomorphism and occasional larger nucleus posed a cytological diagnostic challenge, a diagnosis of benign appendageal tumor was suggested, considering the young age of the patient.
  • This was later confirmed as a clear-cell hidradenoma on excision biopsy.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Skin Neoplasms / pathology

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  • [Copyright] 2009 Wiley-Liss, Inc.
  • (PMID = 19459171.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Alkatan HM: Nodular hidradenoma of the lower eyelid. Can J Ophthalmol; 2007 Feb;42(1):149-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nodular hidradenoma of the lower eyelid.

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  • (PMID = 17361265.001).
  • [ISSN] 0008-4182
  • [Journal-full-title] Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
  • [ISO-abbreviation] Can. J. Ophthalmol.
  • [Language] ENG
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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6. Mahalingam M, Srivastava A, Hoang MP: Expression of stem-cell markers (cytokeratin 15 and nestin) in primary adnexal neoplasms-clues to etiopathogenesis. Am J Dermatopathol; 2010 Dec;32(8):774-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: We evaluated expression of follicular stem-cell markers, cytokeratin (CK) 15 and nestin, in 78 benign and 23 malignant adnexal neoplasms.
  • RESULTS: CK15 and nestin expression were noted in 39 of 78 (50%) and 36 of 78 (46%) cases in the benign group, respectively (8 cutaneous mixed tumor, 10 hidradenoma papilliferum, 9 apocrine cystadenoma, 11 cylindroma and/or spiradenoma, and 9 poroma/dermal duct tumor).
  • Except 1, both markers were negative in 4 syringocystadenoma papilliferum, 10 hidradenoma, 1 syringofibroadenoma, 10 syringoma, 1 eccrine adenoma, 8 poroma/dermal duct tumor, 5 eccrine hidrocystoma, and 1 apocrine carcinoma.
  • CONCLUSIONS: Given that follicular germinative cells give rise to the folliculosebaceous apocrine unit, expression of CK15 and nestin in the majority of cutaneous mixed tumor, hidradenoma papilliferum, apocrine cystadenoma, and cylindroma/spiradenoma is suggestive of an apocrine origin/differentiation of these neoplasms.
  • [MeSH-major] Apocrine Glands / chemistry. Biomarkers, Tumor / analysis. Eccrine Glands / chemistry. Intermediate Filament Proteins / analysis. Keratin-15 / analysis. Neoplasms, Adnexal and Skin Appendage / chemistry. Neoplastic Stem Cells / chemistry. Nerve Tissue Proteins / analysis. Sweat Gland Neoplasms / chemistry

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  • (PMID = 20700038.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Intermediate Filament Proteins; 0 / KRT15 protein, human; 0 / Keratin-15; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin
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7. Ozawa T, Fujiwara M, Nose K, Muraoka M: Clear-cell hidradenoma of the forearm in a young boy. Pediatr Dermatol; 2005 Sep-Oct;22(5):450-2
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  • [Title] Clear-cell hidradenoma of the forearm in a young boy.
  • We treated a 5-year-old boy with clear-cell hidradenoma of the forearm.
  • This presentation demonstrates that clear-cell hidradenoma needs to be considered in the differential diagnosis of cutaneous tumors even in young children, which is of interest because malignant transformation can occur.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16191000.001).
  • [ISSN] 0736-8046
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Toulemonde A, Croue A, Rodien P, Verret JL: [Malignant nodular hidradenoma and multiple nodular hidradenomas in a hypogonadic patient]. Ann Dermatol Venereol; 2006 Dec;133(12):1005-8
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  • [Title] [Malignant nodular hidradenoma and multiple nodular hidradenomas in a hypogonadic patient].
  • BACKGROUND: We report a case of multiple benign nodular hidradenomas associated with malignant nodular hidradenoma in a hypogonadic patient.
  • CASE-REPORT: A 49 year-old man presented 11 benign nodular hidradenomas in the pectoral region.
  • A malignant nodular hidradenoma had recently appeared in this region some distance from the pre-existing benign modular hidradenomas.
  • Large numbers of estrogen receptors were demonstrated in each of the benign nodular hidradenomas.
  • The malignant nodular hidradenoma mass was unavailable and screening for these receptors was not possible.
  • DISCUSSION: Cases of multiple nodular hidradenoma are extremely rare: we have seen only two.
  • To the best of our knowledge, there have been no reports to date of combined malignant nodular hidradenoma and multiple benign nodular hidradenoma.
  • The coexistence of endocrine anomalies associated with this type of tumour has never been reported.
  • However, the presence of estrogen receptors has occasionally been demonstrated in benign nodular hidradenomas.
  • [MeSH-major] Adenoma, Sweat Gland / complications. Hypogonadism / complications. Sweat Gland Neoplasms / complications

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  • (PMID = 17185934.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Receptors, Estrogen
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9. Durairaj VD, Bartlett HM, Said S: Malignant hidradenoma of the medial canthus with orbital and intracranial extension. Ophthal Plast Reconstr Surg; 2006 May-Jun;22(3):229-32
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  • [Title] Malignant hidradenoma of the medial canthus with orbital and intracranial extension.
  • A diagnosis of malignant hidradenoma of the medial canthus was confirmed by histopathology.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Brain Neoplasms / secondary. Eyelid Neoplasms / pathology. Orbital Neoplasms / secondary. Paranasal Sinus Neoplasms / secondary

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  • (PMID = 16714943.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Liapakis IE, Korkolis DP, Koutsoumbi A, Fida A, Kokkalis G, Vassilopoulos PP: Malignant hidradenoma: a report of two cases and review of the literature. Anticancer Res; 2006 May-Jun;26(3B):2217-20
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  • [Title] Malignant hidradenoma: a report of two cases and review of the literature.
  • INTRODUCTION: Malignant tumors of the sweat glands are very rare.
  • Clear cell hidradenoma is a lesion with histopathological features resembling those of eccrine poroma and eccrine spiradenoma.
  • The biological behavior of the tumor is aggressive, with local recurrences reported in more than 50% of the surgically-treated cases.
  • MATERIALS AND METHODS: Two patients are presented, the first with tumor in the right axillary region, the second with a recurrent tumor of the abdominal wall.
  • CONCLUSION: Malignant tumors of the sweat glands are very rare neoplasms with no discrete clinical characteristics.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16821590.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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11. Biedrzycki OJ, Rufford B, Wilcox M, Barton DP, Jameson C: Malignant clear cell hidradenoma of the vulva: report of a unique case and review of the literature. Int J Gynecol Pathol; 2008 Jan;27(1):142-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant clear cell hidradenoma of the vulva: report of a unique case and review of the literature.
  • Clear cell hidradenoma (CCH) is a rare tumor derived from eccrine sweat glands with a predilection for the head, face, and upper extremities.
  • A previously healthy 39-year-old woman underwent marsupialization of a presumed left-side vulval Bartholin gland cyst.
  • Microscopy revealed a tumor with the features of CCH; no atypia, necrosis, or mitoses were observed.
  • Ten months later, she developed enlarging left groin nodes, one of which contained a metastatic clear cell tumor.
  • A reexcision of the vulval primary site, which contained residual tumor, was performed.
  • It also highlights the importance of considering MCCH in the differential diagnosis of a lymph node containing a metastatic clear cell tumor or an apparent metastatic clear cell lesion in the skin.
  • We review the current literature on MCCH and discuss the problems in the differential diagnosis and treatment of this rare tumor.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adult. Bartholin's Glands / pathology. Cysts / pathology. Female. Humans. Immunohistochemistry. Neoplasm Recurrence, Local / pathology

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  • (PMID = 18156989.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Misago N, Narisawa Y: Cytokeratin 15 expression in apocrine mixed tumors of the skin and other benign neoplasms with apocrine differentiation. J Dermatol; 2006 Jan;33(1):2-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytokeratin 15 expression in apocrine mixed tumors of the skin and other benign neoplasms with apocrine differentiation.
  • To clarify the features of apocrine mixed tumors (AMT) of the skin among benign neoplasms with apocrine differentiation in their relationship to follicular stem cells, we investigated the immunohistochemical expression of CK15 (LHK15 and C8/144B), which is a relatively specific marker of hair follicle stem cells in the bulge, in 35 cases of eight different benign neoplasms with presumed apocrine differentiation.
  • None of the other benign neoplasms with presumed apocrine differentiation showed CK15 expression.
  • AMT of the skin are unique among benign neoplasms with apocrine differentiation in their substantial and constant CK15 expression, suggesting that they derive from multipotent epithelial stem cells in the bulge.
  • The partially positive reaction for CK15 in syringocystadenomas papilliferum and spiradenoma/cylindroma may depend on the ability to express CK15 in stem cells with an apocrine fate or result from the follicular and apocrine nature of this neoplasm.
  • [MeSH-major] Apocrine Glands / metabolism. Keratins / metabolism. Sweat Gland Neoplasms / metabolism
  • [MeSH-minor] Adenoma, Sweat Gland / metabolism. Adult. Aged. Biomarkers, Tumor. Case-Control Studies. Cystadenoma / metabolism. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 16469077.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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13. Punia RP, Garg S, Bal A, Mohan H: Pigmented nodular hidradenoma masquerading as nodular malignant melanoma. Dermatol Online J; 2008;14(1):15
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  • [Title] Pigmented nodular hidradenoma masquerading as nodular malignant melanoma.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 18319032.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Hu JC, Ko CJ, Soriano TT, Chiu MW: Syringomatous carcinoma in a young patient treated with Mohs micrographic surgery. Cutis; 2006 Jan;77(1):19-24; quiz 37-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histopathologic examination results showed a dermal neoplasm consisting of nests of basaloid cells, focal areas of ductal differentiation, moderate dermal fibrosis, and moderate nuclear atypia consistent with a diagnosis of SC.
  • The tumor was completely excised Pennsylvania. using Mohs micrographic surgery (MS).
  • This case demonstrates the importance of differentiating SC from other benign or malignant entities, the value of a prompt diagnosis of SC, and the effective treatment of SC with MMS.
  • [MeSH-major] Mohs Surgery. Sweat Gland Neoplasms / pathology. Sweat Gland Neoplasms / surgery. Syringoma / pathology. Syringoma / surgery
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Carcinoembryonic Antigen / analysis. Diagnosis, Differential. Epidermal Cyst / diagnosis. Humans. Immunohistochemistry. Keratins / analysis. Male

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  • (PMID = 16475490.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen; 68238-35-7 / Keratins
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15. Baumhoer D, Pförtner R, Mohr C, Jundt G: Tubulopapillary hidradenoma-like tumor of the mandible. Int J Oral Maxillofac Surg; 2009 Aug;38(8):903-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tubulopapillary hidradenoma-like tumor of the mandible.
  • Tubulopapillary hidradenomas are uncommon benign tumors of the dermis, most commonly occurring in the skin of the head or of the extremities.
  • The authors describe an unusual case of an intraosseous tubulopapillary hidradenoma of the mandible that recurred 1 year after initial curettage and required en-bloc resection.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Mandibular Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Curettage. Diagnosis, Differential. Epithelial Cells / pathology. Follow-Up Studies. Humans. Jaw Cysts / diagnosis. Male. Mandible / surgery. Mandibular Diseases / diagnosis. Neoplasm Recurrence, Local / pathology. Osteolysis / diagnosis. Osteotomy

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  • (PMID = 19375892.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
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16. Sington J, Chandrapala R, Manek S, Hollowood K: Mitotic count is not predictive of clinical behavior in hidradenoma papilliferum of the vulva: a clinicopathologic study of 19 cases. Am J Dermatopathol; 2006 Aug;28(4):322-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mitotic count is not predictive of clinical behavior in hidradenoma papilliferum of the vulva: a clinicopathologic study of 19 cases.
  • Although it is generally recognized that some benign sweat gland neoplasms may show appreciable mitotic activity, there are few reports of its quantitative analysis in specific tumor types or of its correlation with clinical behavior.
  • The presence of a large number of mitoses in a sweat gland tumor for which the histologic criteria of malignancy are not well defined, particularly in association with nuclear abnormalities, may produce a considerable diagnostic challenge.
  • We recently encountered such a problem in a putative case of hidradenoma papilliferum.
  • Therefore, we have undertaken a retrospective clinicopathologic study of 19 cases originally diagnosed as hidradenoma papilliferum or probable hidradenoma papilliferum, with a particular emphasis on the relationship of the mitotic index to clinical behavior.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Mitosis. Vulvar Diseases / pathology

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  • (PMID = 16871035.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Gilaberte Y, Grasa MP, Carapeto FJ: Clear cell hidradenoma. J Am Acad Dermatol; 2006 May;54(5 Suppl):248-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clear cell hidradenoma.
  • [MeSH-major] Acrospiroma / pathology. Leg. Sweat Gland Neoplasms / pathology

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  • [CommentOn] J Am Acad Dermatol. 2000 Apr;42(4):693-5 [10727324.001]
  • (PMID = 16631962.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] United States
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18. Yildiz B, Ozdemir F, Cobanoglu U, Kavgaci H, Fidan E, Aydin F: Clear cell hidradenoma of the gluteal region: a case report. Acta Dermatovenerol Croat; 2009;17(2):144-6
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  • [Title] Clear cell hidradenoma of the gluteal region: a case report.
  • Clear cell hidradenoma is a rare skin appendage tumor.
  • Under the epidermis, an eosinophilic-cytoplasm, uniform-appearance, oval-round-nucleus, benign tumor with cystic and solid components was detected.
  • These results were consistent with clear cell hidradenoma.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Buttocks / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19595274.001).
  • [ISSN] 1330-027X
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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19. Liu HN, Chang YT, Chen CC, Huang CH: Histopathological and immunohistochemical studies of poroid hidradenoma. Arch Dermatol Res; 2006 Jan;297(7):319-23
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  • [Title] Histopathological and immunohistochemical studies of poroid hidradenoma.
  • Poroid hidradenoma (PH), a less common subtype of poroid neoplasm (PN) than eccrine poroma (EP), has not been immunohistochemically studied before.
  • [MeSH-major] Adenoma, Sweat Gland / chemistry. Adenoma, Sweat Gland / pathology. Keratins / analysis. Sweat Gland Neoplasms / chemistry. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Cell Transformation, Neoplastic / pathology. Eccrine Glands / pathology. Epidermis / pathology. Humans. Immunohistochemistry. Male. Melanins / analysis. Middle Aged. Skin Neoplasms / chemistry. Skin Neoplasms / etiology. Skin Neoplasms / pathology

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  • (PMID = 16283345.001).
  • [ISSN] 0340-3696
  • [Journal-full-title] Archives of dermatological research
  • [ISO-abbreviation] Arch. Dermatol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Melanins; 68238-35-7 / Keratins
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20. Mebazaa A, Trabelsi S, Denguezli M, Sriha B, Belajouza C, Nouira R: Chondroid syringoma of the arm: an unusual localization. Dermatol Online J; 2006;12(1):14
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  • Chondroid syringoma (CS) is an uncommon, benign, sweat-gland tumor.
  • This tumor developed slowly over 8 years.
  • There was no recurrence after total excision of the tumor with a 2-year followup.
  • Surgical tumor excision remains the best therapeutic option to avoid relapses of this tumor.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Arm. Sweat Gland Neoplasms / pathology

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  • (PMID = 16638382.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Nazarian RM, Kapur P, Rakheja D, Piris A, Duncan LM, Mihm MC Jr, Hoang MP: Atypical and malignant hidradenomas: a histological and immunohistochemical study. Mod Pathol; 2009 Apr;22(4):600-10
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  • The histological features of atypical hidradenoma are worrisome for increased risk of recurrence and possible malignant potential; however, earlier studies with immunohistochemistry or patient follow-up have not been reported.
  • We compare the histological features and Ki-67, phosphorylated histone H3, epidermal growth factor receptor, and Her2/neu expression profiles of 15 atypical and 15 malignant hidradenomas with those of benign hidradenoma and metastasizing adnexal carcinomas.
  • Significant difference in mean Ki-67% was observed between benign and malignant hidradenomas (P<0.001), benign and metastasizing adnexal carcinomas (0.002), atypical and malignant hidradenomas (P<0.001), and between atypical hidradenomas and metastasizing adnexal carcinomas (0.002).
  • Significant difference in mean phosphorylated histone H3% was observed between benign and malignant hidradenomas (P<0.001), benign and metastasizing adnexal carcinomas (0.003), atypical and malignant hidradenomas (P<0.001), and between atypical hidradenomas and metastasizing adnexal carcinomas (P<0.001).
  • Mean epidermal growth factor receptor total score was significantly different in benign and atypical hidradenoma when compared with that in metastasizing adnexal carcinoma (P=0.014 and 0.019, respectively).
  • A tumor with Ki-67>11% and/or phosphorylated histone H3>0.7% would likely be a malignant rather than an atypical hidradenoma.
  • [MeSH-major] Adenoma, Sweat Gland / metabolism. Adenoma, Sweat Gland / pathology. Biomarkers, Tumor / analysis. Sweat Gland Neoplasms / metabolism. Sweat Gland Neoplasms / pathology

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  • (PMID = 19252473.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Histones; 0 / Ki-67 Antigen; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
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22. Collman DR, Blasko M, Alonzo J, Stess R: Clear cell hidradenoma of the ankle. J Foot Ankle Surg; 2007 Sep-Oct;46(5):387-93
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  • [Title] Clear cell hidradenoma of the ankle.
  • Clear cell hidradenoma is a relatively common, benign eccrine neoplasm with rare presentations in the foot and ankle.
  • Variable clinical and histopathologic characteristics of the tumor warrant careful consideration over primary and recurrent malignancy, particularly eccrine carcinoma.
  • The first known case of primary benign clear cell hidradenoma of the ankle is presented with imaging studies, surgical management, and clinicopathologic correlation, distinguishing the neoplasm from its malignant counterparts.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Ankle / pathology. Foot Diseases / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 17761324.001).
  • [ISSN] 1067-2516
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Angulo J, Jaqueti G, Kutzner H, Requena L: Squamous cell apocrine hidradenoma. J Cutan Pathol; 2007 Oct;34(10):801-3
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  • [Title] Squamous cell apocrine hidradenoma.
  • Apocrine hidradenoma is a benign adnexal neoplasm with apocrine differentiation.
  • The neoplasm is composed of four different types of epithelial cells, including pale or clear cells, polygonal cells, mucinous cells and squamous cells, with variable proportions of them from case to case.
  • In most examples of this neoplasm, clear or the polygonal cells are predominant, whereas the other types of neoplastic cells are less abundant.
  • We report two cases of apocrine hidradenoma mostly composed of squamous cells.
  • The rare cases described in this report are exceptional because most of the neoplastic cells showed squamous appearance and for that reason we think that squamous cell apocrine hidradenoma is the most appropriate name for these neoplasms.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Neoplasms, Squamous Cell / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Apocrine Glands / pathology. Female. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 17880588.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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24. Behboudi A, Winnes M, Gorunova L, van den Oord JJ, Mertens F, Enlund F, Stenman G: Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion. Genes Chromosomes Cancer; 2005 Jun;43(2):202-5
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  • [Title] Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion.
  • Recent studies have shown that the t(11;19)(q21;p13) translocation in mucoepidermoid carcinomas and benign Warthin's tumors results in a fusion of the N-terminal CREB-binding domain of the cAMP coactivator TORC1 (a.k.a.
  • Here we show that a third tumor type, clear cell hidradenoma of the skin, also expresses this gene fusion.
  • RT-PCR analysis of a clear cell hidradenoma with a t(11;19)(q21;p13) translocation revealed expression of a TORC1-MAML2 fusion transcript consisting of exon 1 of TORC1 fused to exons 2-5 of MAML2.
  • These results demonstrate that the t(11;19) in mucoepidermoid carcinoma, Warthin's tumor, and clear cell hidradenoma targets the same genes and results in identical gene fusions, indicating that at least subgroups of these glandular tumors evolve through activation of the same molecular pathways.

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15729701.001).
  • [ISSN] 1045-2257
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CRTC1 protein, human; 0 / DNA Primers; 0 / DNA-Binding Proteins; 0 / MAML2 protein, human; 0 / Nuclear Proteins; 0 / Transcription Factors
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25. Shah BK, Qamruzzaman Y, Serban K, Hire E, Ying SC: First case report of locally advanced malignant nodular hidradenoma of the scrotum. Onkologie; 2010;33(12):701-3
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  • [Title] First case report of locally advanced malignant nodular hidradenoma of the scrotum.
  • BACKGROUND: Malignant nodular hidradenoma (MNH) is a malignant tumor of the eccrine glands, and most commonly involves the head, trunk, and extremities.
  • [MeSH-major] Acrospiroma / pathology. Genital Neoplasms, Male / pathology. Scrotum / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Follow-Up Studies. Humans. Lymph Node Excision. Lymph Nodes / pathology. Lymphatic Metastasis / pathology. Male. Neoplasm Staging

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  • [Copyright] Copyright © 2010 S. Karger AG, Basel.
  • (PMID = 21124043.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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26. Garcia-Bonafe MM, Campins MM, Redecilla PH: Malignant nodular hidradenoma on the scalp: report of a case with fine needle aspiration cytology features and histologic correlation. Acta Cytol; 2009 Sep-Oct;53(5):576-80
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  • [Title] Malignant nodular hidradenoma on the scalp: report of a case with fine needle aspiration cytology features and histologic correlation.
  • BACKGROUND: Malignant nodular hidradenoma (MNH) is a malignant adnexal tumor of the eccrine sweat glands.
  • The histology is similar to that of benign nodular hidradenoma, but MNH shows an infiltrative and invasive pattern, necrosis and angiolymphatic invasion.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Biopsy, Fine-Needle. Head and Neck Neoplasms / pathology. Scalp / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Anaplasia. Cell Differentiation. Female. Giant Cells / pathology. Humans. Immunohistochemistry. Middle Aged. Necrosis. Neoplasm Invasiveness. Predictive Value of Tests

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  • (PMID = 19798887.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Nash JW, Barrett TL, Kies M, Ross MI, Sneige N, Diwan AH, Lazar AJ: Metastatic hidradenocarcinoma with demonstration of Her-2/neu gene amplification by fluorescence in situ hybridization: potential treatment implications. J Cutan Pathol; 2007 Jan;34(1):49-54
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  • A 'benign' nodule had been excised from this location 8 years prior.
  • Histologically, a nodular dermal proliferation composed of poorly differentiated epithelioid cells in nests and focally forming ducts with pseudopapillary architecture comprised the primary tumor.
  • Features of a clear cell hidradenoma were noted focally.
  • Metastatic tumor involved nine of 28 nodes.
  • Interphase fluorescence in situ hybridization (FISH) demonstrated chromosomal amplification of the Her-2/neu locus within the tumor and a nodal metastasis.
  • We believe this to be the first demonstration of Her-2/neu amplification in a malignant skin adnexal tumor.
  • [MeSH-major] Adenoma, Sweat Gland / genetics. Gene Amplification. Genes, erbB-2. In Situ Hybridization, Fluorescence. Lymphatic Metastasis / genetics. Sweat Gland Neoplasms / pathology


28. Gonul M, Cakmak SK, Gul U, Han O, Karagece U: A skin tumor in a young girl. Diagnosis: Clear cell hidradenoma. Indian J Dermatol Venereol Leprol; 2010 Jul-Aug;76(4):445-6
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  • [Title] A skin tumor in a young girl. Diagnosis: Clear cell hidradenoma.

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  • (PMID = 20657141.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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29. Canedo T, de Almeida MP, Cuzzi T, Ramos-e-Silva M: Immunophenotypic aspects of cylindroma and nodular hidradenoma. J Eur Acad Dermatol Venereol; 2010 Feb;24(2):178-85
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  • [Title] Immunophenotypic aspects of cylindroma and nodular hidradenoma.
  • OBJECTIVES: To evaluate the eccrine and/or apocrine differentiation phenotype in cases of cylindroma and clear cell hidradenoma with CD15 and p63 antibodies.
  • METHODOLOGY: Slides and blocks of six cases of cylindroma and seven cases of nodular hidradenoma (clear cells) were analyzed by the technique of immunohistochemistry with CD15 and p63 antibodies.
  • In five of seven cases of nodular hidradenoma (clear cell), we could easily observe clear cells between 20% and 50% of tumour cells.
  • The positivity for p63 antibody, nuclear pattern, was observed in six of seven cases, in the major part of tumour cells.
  • CONCLUSIONS: The present study suggests eccrine origin for both tumours: cylindroma and clear cell hidradenoma.

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  • (PMID = 19796089.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, CD15; 0 / CKAP4 protein, human; 0 / Membrane Proteins
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30. Reid-Nicholson M, Iyengar P, Friedlander MA, Lin O: Fine needle aspiration biopsy of primary mucinous carcinoma of the skin: a case report. Acta Cytol; 2006 May-Jun;50(3):317-22
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  • BACKGROUND: Primary mucinous carcinoma of the skin is a rare neoplasm of sweat gland origin.
  • At the time of wide excision of the residual tumor, sentinel lymph node biopsy revealed a single focus of micrometastasis.
  • CONCLUSION: Cutaneous mucinous carcinoma is a tumor characterized by bland histocytologic features and abundant extracellular pools of mucin.
  • Numerous benign and malignant mucin-producing primary and secondary mimics exist, and immunohistochemistry offers limited benefits in differentiating them.

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  • (PMID = 16780028.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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31. Nemoto N, Suzukawa K, Shimizu S, Shinagawa A, Takei N, Taki T, Hayashi Y, Kojima H, Kawakami Y, Nagasawa T: Identification of a novel fusion gene MLL-MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv(11)(q21q23). Genes Chromosomes Cancer; 2007 Sep;46(9):813-9
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  • MLL-MAML2 in secondary AML/MDS and MECT1-MAML2 in mucoepithelioid carcinoma, benign Wartin's tumor, and clear cell hidradenoma consist of the same COOH-terminal part of MAML2.


32. Rammeh-Rommani S, Ben Ghanem A, Laatiri N, Jenhani F, Fezaa B, Kammoun MR, Baltagi Ben Jilani S, Zermani R: [Study of the ploidy and cellular cycle of hidradenomas and hidradenocarcinomas: a series of 13 cases]. Tunis Med; 2007 May;85(5):409-12
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  • [Transliterated title] Etude de la ploïdie et du cycle cellulaire des hidradenomes et des hidradenocarcinomes: a propos d'une série de 13 cas.
  • AIMS: To study by flow cytometry (FCM) the ploidy and the cellular cycle of nodular hidradenoma (NH) and hidradenocarcinoma (HC) and to assess the prognostic utility of this technique in such tumors.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Cell Cycle. Ploidies. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aneuploidy. DNA, Neoplasm / genetics. Diploidy. Female. Flow Cytometry. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local / genetics. Neoplasm Recurrence, Local / pathology. Prognosis. Retrospective Studies. S Phase

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  • (PMID = 17657929.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Tunisia
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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33. Brown CW Jr, Dy LC: Eccrine porocarcinoma. Dermatol Ther; 2008 Nov-Dec;21(6):433-8
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  • Eccrine porocarcinoma (EPC) is a rare cutaneous neoplasm that grows slowly over a long period of time but often experiences an accelerated growth phase.
  • This malignant tumor may arise denovo or evolve from a pre-existing benign eccrine poroma.
  • [MeSH-major] Acrospiroma / therapy. Sweat Gland Neoplasms / therapy
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Humans. Lymphatic Metastasis. Mohs Surgery. Neoplasm Invasiveness. Neoplasm Staging. Sentinel Lymph Node Biopsy

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  • (PMID = 19076620.001).
  • [ISSN] 1529-8019
  • [Journal-full-title] Dermatologic therapy
  • [ISO-abbreviation] Dermatol Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 53
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34. Cho KE, Son EJ, Kim JA, Youk JH, Kim EK, Kwak JY, Jeong J: Clear cell hidradenoma of the axilla: a case report with literature review. Korean J Radiol; 2010 Jul-Aug;11(4):490-2
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  • [Title] Clear cell hidradenoma of the axilla: a case report with literature review.
  • Clear cell hidradenoma is an uncommon benign skin appendageal tumor that typically involves the dermal layer of the head, face, and extremities.
  • We present a case of clear cell hidradenoma of the axillary tail with radiological findings and a literature review.
  • [MeSH-major] Adenoma, Sweat Gland / radiography. Adenoma, Sweat Gland / ultrasonography. Axilla. Sweat Gland Neoplasms / radiography. Sweat Gland Neoplasms / ultrasonography

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  • (PMID = 20592936.001).
  • [ISSN] 2005-8330
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2893323
  • [Keywords] NOTNLM ; Axilla mass / Hidradenoma / Ultrasonography
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35. Al Baghli A, Reddy SS, Reddy MA: Malignant nodular hidradenoma of the eyelid: a rare sweat gland tumor. Middle East Afr J Ophthalmol; 2010 Oct;17(4):374-6
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  • [Title] Malignant nodular hidradenoma of the eyelid: a rare sweat gland tumor.
  • We report a case of malignant nodular hidradenoma in a middle-aged man, who presented with a nodular swelling in the eyelid.
  • The tumor was similar to its benign counterpart but had additional features such as surface ulceration, numerous mitiotic figures, and an infiltrative growth pattern.

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  • (PMID = 21180442.001).
  • [ISSN] 0975-1599
  • [Journal-full-title] Middle East African journal of ophthalmology
  • [ISO-abbreviation] Middle East Afr J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2991459
  • [Keywords] NOTNLM ; Eccrine Glands / Nodular Hidradenoma / Sweat Gland Tumor
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36. Presutti L, Alicandri-Ciufelli M, Mattioli F, Marchioni D, Costantini M: A case of syryngocystadenoma papilliferum (SCAP) involving middle ear, presenting with otomastoiditis and cerebral abscess. Auris Nasus Larynx; 2008 Sep;35(3):401-3
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  • Syryngocystadenoma papilliferum (SCAP) is an uncommon cutaneous adnexal neoplasm of apocrine gland origin.
  • We describe a case of SCAP of external and middle ear, presenting with otomastoiditis and cerebral abscess; this aggressive behavior, never reported for a benign adenoma of the external or middle ear, could lead to a differential diagnosis with cholesteatoma or malignancies.
  • [MeSH-major] Ear, Middle. Empyema, Subdural / etiology. Mastoiditis / etiology. Streptococcal Infections / etiology. Sweat Gland Neoplasms / diagnosis. Syringoma / diagnosis. Temporal Lobe

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  • (PMID = 17870265.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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37. Suwattee P, McClelland MC, Huiras EE, Warshaw EM, Lee PK, Kaye VN, McCalmont TH, Niehans GA: Plaque-type syringoma: two cases misdiagnosed as microcystic adnexal carcinoma. J Cutan Pathol; 2008 Jun;35(6):570-4
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  • This benign neoplasm may be easily misdiagnosed as microcystic adnexal carcinoma (MAC), potentially resulting in unnecessary surgery with disfiguring consequences.
  • [MeSH-major] Carcinoma, Skin Appendage / diagnosis. Cysts / pathology. Diagnostic Errors. Skin Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis. Syringoma / diagnosis


38. Singhal V, Sharma SC, Anil J, Sachan PK, Harsh M, Singhal S, Raghuvanshi S: Giant benign nodular hidradenoma of the shoulder: A rare tumor in orthopedic practice. Int J Shoulder Surg; 2010 Oct;4(4):93-6
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  • [Title] Giant benign nodular hidradenoma of the shoulder: A rare tumor in orthopedic practice.
  • A clear cell hidradenoma is a rare dermal tumor, which is believed to originate from the apical portion of the sweat glands.
  • We present a giant benign nodular hidradenoma presenting as painful restriction of the right shoulder joint in a 35-year-old male.

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  • [Cites] Korean J Radiol. 2010 Jul-Aug;11(4):490-2 [20592936.001]
  • [Cites] AJR Am J Roentgenol. 1990 Dec;155(6):1251-5 [2122675.001]
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  • (PMID = 21655004.001).
  • [ISSN] 0973-6042
  • [Journal-full-title] International journal of shoulder surgery
  • [ISO-abbreviation] Int J Shoulder Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] South Africa
  • [Other-IDs] NLM/ PMC3100814
  • [Keywords] NOTNLM ; Axillary mass / nodular hidradenoma
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39. Gauerke S, Driscoll JJ: Hidradenocarcinomas: a brief review and future directions. Arch Pathol Lab Med; 2010 May;134(5):781-5
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  • Hidradenocarcinomas are rare, aggressive skin adnexal tumors of sweat gland origin that demonstrate a high potential for local recurrence, metastasis, and poor outcome.
  • These neoplasms can derive from preexisting clear cell hidradenomas but more commonly appear de novo, with the molecular events responsible for the pathogenesis currently unknown.
  • Historically, diagnosis has been difficult because of the few cases, inconsistent nomenclature, variable morphology of cells that compose the neoplasm, and confusion with other visceral metastatic tumors.
  • Presentation is generally benign with an indolent clinical course that typically includes local and multiple recurrences.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 20441512.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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40. Yu G, Goodloe S Jr, D'Angelis CA, McGrath BE, Chen F: Giant clear cell hidradenoma of the knee. J Cutan Pathol; 2010 Sep;37(9):e37-41
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  • [Title] Giant clear cell hidradenoma of the knee.
  • Hidradenomas, also referred to as nodular hidradenomas or clear cell hidradenomas (CCH), are benign cutaneous eccrine tumors usually 2-3 cm in dimension.
  • We report a case of an 8.0 x 6.0 x 3.0 cm clear cell hidradenoma of the left knee in a 43-year-old man.
  • The tumor was mobile, located above the patellar tendon and was without bony involvement on imaging studies.
  • Grossly, the resected tumor was unencapsulated and tan, with a solid and cystic cut surface showing papillary excrescences on the cyst wall.
  • Microscopically, the tumor cells showed an infiltrative growth pattern at the periphery, however, the tumor cytology was bland and no necrosis or mitoses were identified.
  • Immunohistochemically, tumor cells were positive for cytokeratin, CAM5.2, p53, carcino-embryonic antigen (CEA) and epithelial membrane antigen (EMA), and negative for CD10 and Ki-67.
  • [MeSH-major] Acrospiroma / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / secondary. Diagnosis, Differential. Humans. Immunohistochemistry. Kidney Neoplasms / diagnosis. Knee. Magnetic Resonance Imaging. Male. Treatment Outcome

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  • (PMID = 19615032.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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41. Dubb M, Michelow P: Cytologic features of hidradenoma in fine needle aspiration biopsies. Acta Cytol; 2009 Mar-Apr;53(2):179-82
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  • [Title] Cytologic features of hidradenoma in fine needle aspiration biopsies.
  • OBJECTIVE: To review the cytologic features of hidradenoma to describe criteria that may aid in identification of these tumors at the time of aspiration and allow for a more specific diagnosis than the umbrella term of benign skin adnexal tumor.
  • Fine needle aspiration (FNA) of these lesions showed the presence of benign skin adnexal tumors.
  • RESULTS: The following cytomorphologic findings are consistent with the diagnosis of hidradenoma: a cystic component to the aspirate as represented by amorphous background material with or without foam cells and epithelial duct-like cells and tubular structures.
  • CONCLUSION: Knowledge of the cytologic features of hidradenoma will allow for correct management of the patient and prevent misdiagnosis as a malignant tumor.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Head and Neck Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19365971.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Khurshid A, Yaqoob N, Devan HA, Pervez S: 'Nuclear grooves' in nodular hidradenoma: frequency and significance of an unrecognized histopatological feature. J Cutan Pathol; 2007 Nov;34(11):871-5
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  • [Title] 'Nuclear grooves' in nodular hidradenoma: frequency and significance of an unrecognized histopatological feature.
  • BACKGROUND: Nodular hidradenoma is a distinctive sweat gland neoplasm.
  • RESULTS: Totally, 34 cases of nodular hidradenoma were studied.
  • CONCLUSIONS: In this study, we reviewed 34 cases of nodular hidradenoma.
  • [MeSH-major] Adenoma, Sweat Gland / ultrastructure. Sweat Gland Neoplasms / ultrastructure

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  • (PMID = 17944729.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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43. Arias-Santiago S, Aceituno-Madera P, Aneiros-Fernández J, Gutiérrez-Salmerón MT, Naranjo-Sintes R: Syringocystoadenoma papilliferum associated with apocrine hidrocystoma and verruca. Dermatol Online J; 2009;15(11):9
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  • Syringocystoadenoma papilliferum is a benign adnexal tumor usually located in head and neck that occurs during childhood or adolescence.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Hidrocystoma / pathology. Neoplasms, Multiple Primary / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Biopsy, Needle. Cystadenoma / complications. Cystadenoma / pathology. Cystadenoma / surgery. Follow-Up Studies. Humans. Immunohistochemistry. Male. Neoplasm Staging. Risk Assessment. Thoracic Wall. Treatment Outcome. Young Adult

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  • (PMID = 19951645.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Mote DG, Ramamurti T, Naveen Babu B: Nodular hidradenoma of the breast: A case report with literature review. Indian J Surg; 2009 Feb;71(1):43-5
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  • [Title] Nodular hidradenoma of the breast: A case report with literature review.
  • Nodular hidradenoma or clear cell hidradenoma is a rare skin adenexal tumor which arises from eccrine sweat glands.
  • Final diagnosis of nodular hidradenoma was made only after excision biopsy as fi ne needle aspiration cytology was inconclusive.

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  • [Cites] J Surg Oncol. 1986 Mar;31(3):191-8 [3014220.001]
  • [Cites] Diagn Cytopathol. 1996 Jul;15(1):70-2 [8807256.001]
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  • (PMID = 23133109.001).
  • [ISSN] 0972-2068
  • [Journal-full-title] The Indian journal of surgery
  • [ISO-abbreviation] Indian J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3452564
  • [Keywords] NOTNLM ; Adenexal tumor / Carcinoma breast / Nodular hidradenoma
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45. Sierra Montenegro E, Sierra Luzuriaga G, Leone Stay G, Salazar Menéndez V, Quiñonez Auria C: Perianal nodular hidradenocarcinoma. Case report. Cir Cir; 2010 Mar-Apr;78(2):173-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Eccrine glands (sweat glands) appear in all sites of the skin and are more abundant in hands and feet.
  • Nodular hidradenocarcinoma (NH) is a rare malignant and aggressive tumor of the eccrine glands.
  • Physical examination revealed a small perianal tumor that was palpated near the anal canal.
  • Pathology report revealed perianal hidradenoma.
  • Extensive resection of the tumor was done.
  • [MeSH-major] Eccrine Glands. Sweat Gland Neoplasms

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  • (PMID = 20478121.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Mexico
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46. Avilés-Izquierdo JA, Velázquez-Tarjuelo D, Lecona-Echevarría M, Lázaro-Ochaita P: [Dermoscopic features of eccrine poroma]. Actas Dermosifiliogr; 2009 Mar;100(2):133-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Eccrine poroma is a benign adnexal neoplasm that clinically may mimic malignant skin tumors such as squamous cell carcinoma and amelanotic melanoma.
  • Dermoscopy can improve the clinical diagnosis of this benign adnexal skin tumor.
  • [MeSH-major] Acrospiroma / pathology. Dermoscopy. Foot Diseases / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19445878.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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47. Barré C, Lorenzato M, Bourdat B, Quéreux C, Durlach A: [Vulvar invasive squamous cell carcinoma and hidradenoma papilliferum. Case report]. Gynecol Obstet Fertil; 2007 Sep;35(9):776-9
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  • [Title] [Vulvar invasive squamous cell carcinoma and hidradenoma papilliferum. Case report].
  • We report a case of a vulvar invasive squamous cell carcinoma associated to a benign tumor with apocrine differenciation, the hidradenoma papilliferum, infiltrated by the carcinoma.
  • Classical association between hidradenoma papilliferum and Paget's disease is described, but to the best of our knowledge, there have been no previous reports of such case in published literature.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Vulvar Neoplasms / secondary
  • [MeSH-minor] Aged. Biopsy. Female. Humans. Neoplasm Invasiveness

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  • (PMID = 17766164.001).
  • [ISSN] 1297-9589
  • [Journal-full-title] Gynécologie, obstétrique & fertilité
  • [ISO-abbreviation] Gynecol Obstet Fertil
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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48. Battistella M, Langbein L, Peltre B, Cribier B: From hidroacanthoma simplex to poroid hidradenoma: clinicopathologic and immunohistochemic study of poroid neoplasms and reappraisal of their histogenesis. Am J Dermatopathol; 2010 Jul;32(5):459-68
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  • [Title] From hidroacanthoma simplex to poroid hidradenoma: clinicopathologic and immunohistochemic study of poroid neoplasms and reappraisal of their histogenesis.
  • BACKGROUND: Poroid neoplasms comprise classic poroma (P), hidroacanthoma simplex (HS), dermal duct tumor (DDT), and poroid hidradenoma (PH).
  • Poroid cells in P have recently been identified as keratinocytes of the lowermost acrosyringium and the sweat duct ridge.
  • METHODS: 202 P, 11 HS, 17 DDT, 31 PH, and 5 composite tumors were examined under light microscopy, and 11, 9, 10, 15, and 2, respectively, by immunohistochemistry using anti-keratin antibodies, in particular, anti-K77, specific for luminal cells of the eccrine dermal sweat duct, and Ki-67 antibody.
  • CONCLUSIONS: Our data demonstrate the common histogenesis of the 4 poroid neoplasms, which seem to derive from the basal keratinocytes of the sweat duct ridge and the lower acrosyringium.
  • The variable length of the sweat duct ridge may account for the variety of poroid neoplasms, according to the site of tumor induction along this structure.
  • [MeSH-major] Acanthoma / pathology. Acrospiroma / pathology. Keratinocytes / pathology. Keratins / metabolism. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Dermis / metabolism. Dermis / pathology. Female. Humans. Immunohistochemistry. Ki-67 Antigen / metabolism. Male. Middle Aged. Necrosis. Retrospective Studies. Sweat Glands / metabolism. Sweat Glands / pathology. Young Adult

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  • (PMID = 20571345.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 68238-35-7 / Keratins
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49. Jukic DM, Drogowski LM, Davie JR: Carcinoma ex spiradenoma/cylindroma confirmed by immunohistochemical and molecular loss-of-heterozygosity profiling. Am J Dermatopathol; 2009 Oct;31(7):702-8
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  • Histopathological exam revealed a benign eccrine spiradenoma/cylindroma and an intermixed carcinoma, with a differential diagnosis of either primary eccrine carcinoma or mammary carcinoma metastatic to the spiradenoma/cylindroma.
  • This neoplasm is referred to in the literature as carcinoma ex spiradenoma/cylindroma and spiradenocylindrocarcinoma.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19684510.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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50. Kazakov DV, Vanecek T, Belousova IE, Mukensnabl P, Kollertova D, Michal M: Skin-type hidradenoma of the breast parenchyma with t(11;19) translocation: hidradenoma of the breast. Am J Dermatopathol; 2007 Oct;29(5):457-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Skin-type hidradenoma of the breast parenchyma with t(11;19) translocation: hidradenoma of the breast.
  • We report herein a case of solid-cystic hidradenoma of the breast.
  • The tumor was situated in the parenchyma of the breast of a 55-year-old female and showed no connection to the overlying skin on ultrasound and radiology investigations, grossly and microscopically.
  • Histologically, the tumor was identical to its cutaneous counterpart and was surrounded by breast tissue.
  • The neoplasm was composed of solid and cystic areas.
  • Several mammary ducts in close proximity to the tumor showed features of columnar cell hyperplasia.
  • [MeSH-major] Adenoma, Sweat Gland / genetics. Breast Neoplasms / genetics. Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 19. Translocation, Genetic / genetics

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  • (PMID = 17890914.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MECT1-MAML2 fusion protein, human; 0 / Oncogene Proteins, Fusion
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51. Veeranna S, Vijaya: Solitary nodule over the labia majora. Hidradenoma papilliferum. Indian J Dermatol Venereol Leprol; 2009 May-Jun;75(3):327-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary nodule over the labia majora. Hidradenoma papilliferum.
  • [MeSH-major] Acrospiroma / diagnosis. Sweat Gland Neoplasms / diagnosis. Vulva / pathology
  • [MeSH-minor] Adult. Apocrine Glands / pathology. Apocrine Glands / surgery. Female. Humans

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  • (PMID = 19439903.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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52. MacNeill KN, Riddell RH, Ghazarian D: Perianal apocrine adenocarcinoma arising in a benign apocrine adenoma; first case report and review of the literature. J Clin Pathol; 2005 Feb;58(2):217-9
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  • [Title] Perianal apocrine adenocarcinoma arising in a benign apocrine adenoma; first case report and review of the literature.
  • Benign apocrine lesions have been described in the anogenital region, although according to the World Health Organisation convincing examples of anal apocrine adenocarcinomas have not been published.
  • This report describes the case of an invasive apocrine adenocarcinoma arising in a benign adenoma in the perianal region of a 45 year old woman.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Sweat Gland / pathology. Anus Neoplasms / pathology. Apocrine Glands / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Female. Humans. Immunohistochemistry / methods. Middle Aged. Neoplasm Invasiveness


53. Zhou HM, Lang JH, Zhu L, Guo LN: [Clinical and pathological analysis of rare nonepithelial vulvar tumors]. Zhonghua Fu Chan Ke Za Zhi; 2008 Jul;43(7):490-2
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  • Among the pathological diagnoses after operation, the most common benign histological subtypes were hidradenoma and haemangioma, while the most common malignant histological subtypes were leiomyosarcoma and aggressive angiomyxoma.
  • [MeSH-minor] Adult. Aged. Colposcopy. Female. Follow-Up Studies. Humans. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Syringoma / diagnosis. Syringoma / pathology. Syringoma / surgery. Vulva / pathology. Vulva / surgery. Young Adult

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  • (PMID = 19080509.001).
  • [ISSN] 0529-567X
  • [Journal-full-title] Zhonghua fu chan ke za zhi
  • [ISO-abbreviation] Zhonghua Fu Chan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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54. Kazakov DV, Kutzner H, Spagnolo DV, Kempf W, Zelger B, Mukensnabl P, Michal M: Sebaceous differentiation in poroid neoplasms: report of 11 cases, including a case of metaplastic carcinoma associated with apocrine poroma (sarcomatoid apocrine porocarcinoma). Am J Dermatopathol; 2008 Feb;30(1):21-6
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  • Six lesions had the silhouette of a classical poroma, 3 of poroid hidradenoma and 1 of dermal duct tumor.
  • The single carcinoma was an ulcerated oval to spindle cell neoplasm surrounded laterally by the residuum of a poroma containing groups of sebocytes.
  • Our study supports previous findings that sebaceous differentiation can be identified not only in classical poroma but also in the related lesions known as dermal duct tumor and poroid hidradenoma.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Neoplasms, Multiple Primary / pathology. Sarcoma / pathology. Sebaceous Glands / pathology. Skin Neoplasms / pathology

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  • (PMID = 18212539.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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55. Ohi Y, Umekita Y, Rai Y, Kukita T, Sagara Y, Sagara Y, Takahama T, Andou M, Sagara Y, Yoshida A, Yoshida H: Clear cell hidradenoma of the breast: a case report with review of the literature. Breast Cancer; 2007;14(3):307-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clear cell hidradenoma of the breast: a case report with review of the literature.
  • Clear cell hidradenoma of the breast is rare.
  • A 55-year-old woman demonstrated a left breast tumor during follow-up examination of the right breast.
  • Focal asymmetric density was shown on mammogram, and ultrasonography showed an intracystic tumor.
  • The lesion was an intracystic tumor macroscopically.
  • Histological examination demonstrated characteristic histological features of clear cell hidradenoma, such as proliferation of uniform epithelial cells, clear or slightly eosinophilic cytoplasm, and cuboidal cell-lined ductal structures.
  • These features were consistent with clear cell hidradenoma.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Breast Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 17690510.001).
  • [ISSN] 1340-6868
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 16
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56. Kazakov DV, Ivan D, Kutzner H, Spagnolo DV, Grossmann P, Vanecek T, Sima R, Kacerovska D, Shelekhova KV, Denisjuk N, Hillen U, Kuroda N, Mukensnabl P, Danis D, Michal M: Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her2/neu gene expression/amplification, TP53 gene mutation analysis, and t(11;19) translocation. Am J Dermatopathol; 2009 May;31(3):236-47
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  • The residuum of a hidradenoma was present in 5 of the 14 primaries.
  • Glandular differentiation varied from case to case and appeared most commonly as simple round glands or as cells with intracytoplasmic lumens.
  • Despite the bland appearance, the tumor metastasized to a lymph node.
  • It is concluded that cutaneous hidradenocarcinomas show some microscopic heterogeneity and comprise both low- and high-grade lesions that cytologically are similar to their benign counterpart, the hidradenoma.
  • [MeSH-major] Adenocarcinoma / pathology. Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 19. Gene Amplification. Mutation. Receptor, ErbB-2 / genetics. Sweat Gland Neoplasms / pathology. Translocation, Genetic. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 19384064.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / ERBB2 protein, human; EC 2.7.10.1 / Receptor, ErbB-2
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57. Ben Brahim E, Sfia M, Tangour M, Makhlouf R, Cribier B, Chatti S: Malignant eccrine spiradenoma: a new case report. J Cutan Pathol; 2010 Apr;37(4):478-81
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  • Malignant eccrine spiradenoma is an extremely rare skin tumor of sweat gland origin.
  • In most cases, it arises in pre-existing benign eccrine spiradenoma.
  • The gross pathologic specimen showed a large cutaneous and subcutaneous multinodular tumor, measuring 6 cm in maximal dimension.
  • Microscopically, there were two distinct morphological components: a benign eccrine spiradenoma and a malignant eccrine spiradenoma of low grade with extensive necrosis.
  • Extensive sampling to look for a probable previously benign component is necessary.
  • [MeSH-major] Acrospiroma / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Humans. Male. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Treatment Outcome

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  • (PMID = 19614990.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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58. Segal A, Segal N, Gal A, Tumuluri K: Mucinous sweat gland adenocarcinoma of the eyelid - current knowledge of a rare tumor. Orbit; 2010 Dec;29(6):334-40
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  • [Title] Mucinous sweat gland adenocarcinoma of the eyelid - current knowledge of a rare tumor.
  • PURPOSE: To review the medical literature on mucinous sweat gland adenocarcinoma of the eyelid (MSA) and present two new cases.
  • In 12(21.8%) patients a lesion with a benign diagnosis was previously excised from the same location.
  • Recurrence of the tumor was reported in 14(30%) patients.
  • CONCLUSIONS: MSA is a rare tumor of the eyelid with no clinically distinguishing features.
  • The tumor may extend into the orbit and metastasize regionally.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Eyelid Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Mohs Surgery / methods. Neoplasm Staging. Rare Diseases. Risk Assessment. Treatment Outcome

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  • (PMID = 21158574.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
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59. Doganavsargil B, Akalin T, Ylmaz M, Kandiloglu G: Perianal fibroadenoma, case report. Am J Dermatopathol; 2008 Feb;30(1):81-3
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  • Extramammary fibroadenomas, occurring in the anogenital region, are rare lesions thought to be arising from "mammary-like anogenital sweet glands" described by van der Putte.
  • Low columnar or cuboidal cells with focal, apical cytoplasmic snouts lined the glands, whereas the underlying layer had myoepithelial cell features, expressing smooth muscle actin and S-100.
  • The case is presented to increase the awareness on mammary-like glands of anogenital region, which may give rise to not only fibroadenomas but also fibrocystic disease, phyllodes tumor, carcinoma in situ, invasive carcinoma and lactating adenoma, hidrocystoma, hidradenoma papilliferum, intraductal papilloma, and sclerosing adenosis, although very rare.

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  • (PMID = 18212553.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. Plaza JA, Ortega PF, Stockman DL, Suster S: Value of p63 and podoplanin (D2-40) immunoreactivity in the distinction between primary cutaneous tumors and adenocarcinomas metastatic to the skin: a clinicopathologic and immunohistochemical study of 79 cases. J Cutan Pathol; 2010 Apr;37(4):403-10
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  • The distinction of metastatic carcinomas to the skin from poorly differentiated primary cutaneous carcinomas and sometimes primary benign adnexal tumors can pose a significant diagnostic challenge.
  • The 37 primary cutaneous tumors included 14 cases of benign adnexal tumors, 9 malignant skin adnexal neoplasms, and 14 primary squamous and basal cell carcinomas.
  • The 42 metastatic adenocarcinomas all corresponded to metastases from patients with a well-documented history of a primary tumor at another location.
  • We found variable positivity with podoplanin in all primary cutaneous neoplasms including spiradenoma (6/6), hidradenoma (2/4), cylindroma (3/3), desmoplastic trichilemmoma (1/1), poorly differentiated squamous cell carcinoma (4/4), sebaceous carcinoma (1/1), basal cell carcinoma (4/10), trichilemmal carcinoma (2/2), eccrine carcinoma (3/3), microcystic adnexal carcinoma (1/1), adnexal carcinoma NOS (1/1), and porocarcinoma (1/1).

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  • (PMID = 20377670.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / Membrane Glycoproteins; 0 / Membrane Proteins; 0 / PDPN protein, human
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61. Uke MS, Kulkarni MB, Ajit D, Gujral S: Diagnosis of hidradenoma papilliferum of the vulva on cytologic smears: a case report. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):907-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis of hidradenoma papilliferum of the vulva on cytologic smears: a case report.
  • BACKGROUND: Hidradenoma papilliferum is a rare benign tumor of the vulva that occurs mainly in women in the skin of the anogenital region.
  • Clinically it may mimic a carcinoma, so the correct cytologic interpretation of the tumor cells with subsequent careful histologic confirmation is essential for good management.
  • Fine needle aspiration cytology and vulvar scraping of the lesion were reported as a malignant tumor, and the case was referred to our center for further management.
  • Repeat vulvar smears showed mainly groups and clusters of benign-looking glandular cells and were interpreted as a benign tumor.
  • Subsequent histology confirmed the diagnosis of hidradenoma papilliferum.
  • CONCLUSION: This case highlights the cytologic features of hidradenoma papilliferum on cytologic smears.
  • The clinical presentation should not mislead the cytologic interpretation of the tumor cells.
  • [MeSH-major] Acrospiroma / diagnosis. Cytological Techniques. Sweat Gland Neoplasms / diagnosis. Vulva / pathology

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  • (PMID = 21053567.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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62. Tolland JP, Brenn T, Guldbakke KK, Schanbacher CF: Mohs micrographic surgery, sentinel lymph node mapping, and estrogen receptor analysis for the treatment of malignant nodular hidradenoma. Dermatol Surg; 2006 Oct;32(10):1294-301
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mohs micrographic surgery, sentinel lymph node mapping, and estrogen receptor analysis for the treatment of malignant nodular hidradenoma.
  • [MeSH-major] Adenoma, Sweat Gland. Mohs Surgery / methods. Receptors, Estrogen / metabolism. Sweat Gland Neoplasms
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Follow-Up Studies. Foot. Humans. Immunohistochemistry. Male. Sentinel Lymph Node Biopsy

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  • (PMID = 17034384.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, Estrogen
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63. Piana S, Tagliavini E: Papillary poroid hidradenoma. Am J Dermatopathol; 2010 Feb;32(1):101-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary poroid hidradenoma.
  • [MeSH-major] Carcinoma, Papillary / pathology. Poroma / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Humans. Keratins / metabolism. Male. Thigh

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  • (PMID = 19730081.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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64. Bollée G, Patey N, Cazajous G, Robert C, Goujon JM, Fakhouri F, Bruneval P, Noël LH, Knebelmann B: Thrombotic microangiopathy secondary to VEGF pathway inhibition by sunitinib. Nephrol Dial Transplant; 2009 Feb;24(2):682-5
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  • A 44-year-old woman with a history of malignant skin hidradenoma was started on sunitinib for refractory disease.
  • [MeSH-minor] Adenoma, Sweat Gland / drug therapy. Adult. Antineoplastic Agents / adverse effects. Female. Humans. Protein Kinase Inhibitors / adverse effects. Skin Neoplasms / drug therapy

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  • [CommentIn] Nephrol Dial Transplant. 2009 Jun;24(6):2002-3 [19332867.001]
  • (PMID = 19054798.001).
  • [ISSN] 1460-2385
  • [Journal-full-title] Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • [ISO-abbreviation] Nephrol. Dial. Transplant.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Indoles; 0 / Protein Kinase Inhibitors; 0 / Pyrroles; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 0 / sunitinib
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65. Goh SG, Carr R, Dayrit JF, Calonje E: Mucinous hidradenoma: a report of three cases. J Cutan Pathol; 2007 Jun;34(6):497-502
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  • [Title] Mucinous hidradenoma: a report of three cases.
  • We describe three cases of mucinous hidradenoma characterized by diffuse and prominent mucinous cell proliferation and discuss the relevant literature.
  • Case 1 presented as a 1.3-cm eyelid nodule and histology showed a mucinous apocrine hidradenoma with a proliferation of mucinous cells and apocrine glands.
  • The tumor was also interpretated as a mucinous hidradenoma, most likely of follicular-apocrine origin.
  • The histology showed a mucinous clear-cell hidradenoma composed of numerous mucinous glands amidst small squamous cells with clear cytoplasm and a hyalinized fibrovascular stroma.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Cystadenoma, Mucinous / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17518780.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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66. Oo KZ, Xiao PQ: Infiltrating syringomatous adenoma of the nipple: clinical presentation and literature review. Arch Pathol Lab Med; 2009 Sep;133(9):1487-9
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  • Infiltrating syringomatous adenoma of the nipple is a rare neoplasm of the breast.
  • Despite its benign behavior, syringomatous adenoma of the nipple usually shows infiltrative expansile proliferation into adjacent tissue and underlying breast tissue.
  • Special attention given to this tumor by pathologists and clinicians can avoid misdiagnosis and unnecessary treatment.
  • [MeSH-major] Breast Neoplasms / pathology. Nipples / pathology. Sweat Gland Neoplasms / pathology. Syringoma / pathology

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  • (PMID = 19722761.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 16
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67. Guan Y, Xiao Y, Ji HA, Xue CW, Li P: [Poroid hidradenoma: a case report]. Zhonghua Bing Li Xue Za Zhi; 2006 Jun;35(6):378-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Poroid hidradenoma: a case report].
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Skin Neoplasms / pathology

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  • (PMID = 16834920.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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68. Scurry J, van der Putte SC, Pyman J, Chetty N, Szabo R: Mammary-like gland adenoma of the vulva: review of 46 cases. Pathology; 2009;41(4):372-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mammary-like gland adenoma of the vulva: review of 46 cases.
  • AIMS: Hidradenoma papilliferum (HP) of the anogenital region, which was previously thought to be an apocrine tumour, is now believed to be derived from anogenital mammary-like glands (MLG) and is more accurately termed MLG adenoma.
  • We sought to explore any ramifications that may have resulted from the perceived change in histogenesis of this tumour.
  • Tumours occurred in the known distribution of mammary-like glands.
  • [MeSH-major] Adenoma / pathology. Mammary Glands, Human / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 19404851.001).
  • [ISSN] 1465-3931
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 46
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69. Bekler H, Gokce A, Beyzadeoglu T: Chondroid syringoma of the hand: a rare localization. Handchir Mikrochir Plast Chir; 2007 Dec;39(6):430-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondroid syringoma is a rare benign neoplasm of the sweat glands that usually occurs in the head and neck region.
  • We describe a 18-year-old male patient with a benign chondroid syringoma that occurred at an unusual site, leading to compression symptoms of the ulnar nerve causing symptoms at the hypothenar region of the right hand.
  • Although it is a rare tumor at an unusual site, it should be included in the differential diagnosis of the hand tumors.
  • [MeSH-minor] Adolescent. Biopsy. Humans. Image Enhancement. Magnetic Resonance Imaging. Male. Muscle, Skeletal / pathology. Neoplasm Invasiveness

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  • (PMID = 18058676.001).
  • [ISSN] 0722-1819
  • [Journal-full-title] Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der Peripheren Nerven und Gefässe : Organ der Vereinigung der Deutschen Plastischen Chirurgen
  • [ISO-abbreviation] Handchir Mikrochir Plast Chir
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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70. Smiri KH, Fenniche S, Marrak H, Daoud L, Debbiche A, Ben Ayed M, Mokhtar I: [Chondroid syringoma]. Tunis Med; 2005 Jun;83(6):372-4
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  • Chondroid syringoma is a benign sweat gland tumor.
  • This lesion is electively located in the craniofacial area, made of a subcutaneous painless tumor measuring from 0.5 to 3 cm.
  • Diagnosis can always be confirmed by histology which shows tubuloalveolar and gland like structures with two or more cuboidal cell lines in a fibroadipoid or chondroid stroma that is positively stained for Alcian blue.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Salivary Gland Neoplasms / surgery

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  • (PMID = 16156416.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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71. Monteagudo B, Iglesias B, de la Torre C, Paredes C, Vázquez-Blanco M, Ginarte M, Labandeira J: [Poroid hidradenoma]. Actas Dermosifiliogr; 2005 Jul-Aug;96(6):398-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Poroid hidradenoma].
  • Poroid hidradenoma is a recently described variant of eccrine poroma.
  • This neoplasm presents structural findings of hidradenoma (solid and cystic areas) and cytological characteristics of poromas (poroid and cuticular cells, the latter showing ductal differentiation).
  • We present a case of poroid hidradenoma in a 74-year-old woman, who consulted her physician because of a nodular lesion on the left buttock.
  • [MeSH-major] Acrospiroma / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16476263.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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72. Rosmaninho AD, de Almeida MT, Costa V, Sanches MM, Lopes C, Selores Gomes Meirinhos MM: Ectopic hidradenoma papilliferum. Dermatol Res Pract; 2010;2010:709371
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ectopic hidradenoma papilliferum.
  • Hidradenoma papilliferum is a rare tumor that occurs almost exclusively in females on the anogenital area.
  • Rare cases of ectopic (nongenital) hidradenoma papilliferum have been described.
  • The histological findings revealed a hidradenoma papilliferum.
  • So far, among the very few reports of ectopic hidradenoma papilliferum, only a very small number were localized to the eyelid.

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  • [Cites] J Am Acad Dermatol. 1999 Jul;41(1):115-8 [10411423.001]
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  • (PMID = 21197082.001).
  • [ISSN] 1687-6113
  • [Journal-full-title] Dermatology research and practice
  • [ISO-abbreviation] Dermatol Res Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC3004393
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73. Gouiaa N, Abbes K, Fakhfekh I, Ayadi L, Bahri I, Chaari C, Ellouze S, Chtourou I, Makni S, Sellami-Boudawara T: [Hidradenocarcinoma arising from pre-existing hidradenoma]. Ann Dermatol Venereol; 2008 Oct;135(10):714-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Hidradenocarcinoma arising from pre-existing hidradenoma].
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Sweat Gland / pathology. Cell Transformation, Neoplastic / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18929928.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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74. Vazmitel M, Pavlovsky M, Kacerovska D, Michal M, Kazakov DV: Pseudoangiomatous stromal hyperplasia in a complex neoplastic lesion involving anogenital mammary-like glands. J Cutan Pathol; 2009 Oct;36(10):1117-20
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  • [Title] Pseudoangiomatous stromal hyperplasia in a complex neoplastic lesion involving anogenital mammary-like glands.
  • Anogenital mammary-like glands (AMLG) may give rise to various pathologic lesions identical to those known in mammary pathology.
  • Pseudoangiomatous stromal hyperplasia (PASH), a relatively frequent hormonal change associated with different benign and malignant processes in the breast, was only once mentioned in the literature concerning the pathology of AMLG.
  • The present case of PASH is remarkable because of its occurrence within a complex lesion evidencing the changes identical to or reminiscent of blunt duct adenosis, fibroadenoma and hidradenoma papilliferum.
  • [MeSH-major] Mammary Glands, Human / pathology. Neoplasms, Complex and Mixed / pathology. Neoplasms, Multiple Primary / pathology. Vulvar Neoplasms / pathology

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  • [Copyright] 2009 John Wiley & Sons A/S.
  • (PMID = 19508499.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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75. Monteagudo B, Antón-Badiola IM, Muñoz MJ, Paredes-Suárez C, Vázquez-Blanco M: [Pigmented apocrine hidradenoma]. Actas Dermosifiliogr; 2005 Jan-Feb;96(1):50-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pigmented apocrine hidradenoma].
  • Apocrine hidradenoma is a benign adnexal neoplasm.
  • The same as other tumors of the sweat glands, there is a pigmented variety.
  • After the histopathological study, the diagnosis was established as pigmented apocrine hidradenoma.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Hyperpigmentation / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16476334.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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76. Obaidat NA, Awamleh AA, Ghazarian DM: Adenocarcinoma in situ arising in a tubulopapillary apocrine hidradenoma of the peri-anal region. Eur J Dermatol; 2006 Sep-Oct;16(5):576-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma in situ arising in a tubulopapillary apocrine hidradenoma of the peri-anal region.
  • Histologically, the excised lesion showed features of tubulopapillary apocrine hidradenoma, with an area showing features of carcinoma in situ.
  • Similar to vulvar lesions, peri-anal apocrine tumours are believed to arise in mammary like glands (MLGs).
  • To the best of our knowledge, this is the first description of a peri-anal adenocarcinoma in situ arising in a tubulopapillary apocrine hidradenoma.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Sweat Gland / pathology. Anus Neoplasms / pathology. Carcinoma in Situ / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17101482.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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77. Ishida M, Kojima F, Kushima R, Kakutani A, Okabe H: [Case of clear cell hidradenoma with mucinous metaplasia in the forehead--immunohistochemical analysis of the mucin]. Rinsho Byori; 2006 Aug;54(8):781-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Case of clear cell hidradenoma with mucinous metaplasia in the forehead--immunohistochemical analysis of the mucin].
  • Here we report a new case of clear cell hidradenoma with mucinous metaplasia in the forehead.
  • Our immunohistochemical analysis revealed MUC5AC in the mucinous metaplastic cells of this tumor as in the extramammary Paget's disease, and expression of this gastric foveolar epithelial mucin core protein in these two neoplastic conditions seem to related to their common apocrine origin.
  • [MeSH-major] Adenoma, Sweat Gland / metabolism. Adenoma, Sweat Gland / pathology. Forehead. Mucins / analysis. Sweat Gland Neoplasms / metabolism. Sweat Gland Neoplasms / pathology

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  • (PMID = 16989395.001).
  • [ISSN] 0047-1860
  • [Journal-full-title] Rinsho byori. The Japanese journal of clinical pathology
  • [ISO-abbreviation] Rinsho Byori
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucins
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78. Moon JW, Na CH, Kim HR, Shin BS: Giant ectopic hidradenoma papilliferum on the scalp. J Dermatol; 2009 Oct;36(10):545-7
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  • [Title] Giant ectopic hidradenoma papilliferum on the scalp.
  • [MeSH-major] Acrospiroma / pathology. Head and Neck Neoplasms / pathology. Scalp / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19785709.001).
  • [ISSN] 1346-8138
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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79. Markou K, Karasmanis I, Vlachtsis K, Petridis D, Nikolaou A, Vital V: Primary pleomorphic adenoma of the external ear canal. Report of a case and literature review. Am J Otolaryngol; 2008 Mar-Apr;29(2):142-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ceruminal glands are modified sweat glands of the skin of the external auditory meatus that may give rise to (a) benign tumors such as ceruminous adenoma, pleomorphic adenoma, and syringocystadenoma papilliferum, and (b) malignant tumors such as ceruminous adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma.
  • These tumors are very rare and usually have a benign course.
  • Magnetic resonance imaging showed no intracranial extension or any association with the adjacent parotid gland.
  • The patient underwent modified radical mastoidectomy and complete resection of the tumor and the entire skin of the external auditory canal.
  • CONCLUSIONS: Pleomorphic adenoma is an extremely rare tumor arising from the ceruminal glands of the external ear canal.
  • Nonspecific presentation and difficult histologic diagnosis characterize this benign neoplasm.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Ear, External / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 18314029.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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80. Al-Faky YH, Al-Mosallam AR, Al-Sohaibani MO: Periocular hidradenoma papilliferum. Saudi J Ophthalmol; 2009 Oct;23(3-4):211-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Periocular hidradenoma papilliferum.
  • Hidradenoma is a benign adnexal neoplasm originating from the apocrine sweat gland, and is almost exclusively detectable in the skin of the anogenital area of middle-aged white females after puberty.
  • Ectopic hidradenoma papilliferum, which involves the skin away from the anogenital region, is exceedingly rare, and can also affect males.

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  • (PMID = 23960862.001).
  • [ISSN] 1319-4534
  • [Journal-full-title] Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
  • [ISO-abbreviation] Saudi J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Other-IDs] NLM/ PMC3729807
  • [Keywords] NOTNLM ; Childhood / Ectopic / Hidradenoma papilliferum
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81. Kim JY, Kim YC, Lee ES: Solitary eccrine syringofibroadenoma with prominent plasma cell infiltration. J Dermatol; 2007 Feb;34(2):138-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Eccrine syringofibroadenoma (ESFA) is a rare, benign, adnexal neoplasm thought to be eccrine ductal differentiation displaying variable clinical findings and characteristic histological features.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Eccrine Glands / pathology. Plasma Cells / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17239154.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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82. de Koning HD, Bovenschen HJ: Two adjacent nodules on the leg. Dermatol Online J; 2010;16(6):13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Poroma is a rare benign neoplasm (derived from the intraepidermal part of the eccrine or apocrine duct), which may clinically mimic malignant tumors such as (amelanotic) malignant melanoma and porocarcinoma.
  • Despite a clinical differential diagnosis of melanoma, histopathology showed the typical characteristics of a poroma, a rare but much more favorable tumor.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Leg. Poroma / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 20579468.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Shah SS, Adelson M, Mazur MT: Adenocarcinoma in situ arising in vulvar papillary hidradenoma: report of 2 cases. Int J Gynecol Pathol; 2008 Jul;27(3):453-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma in situ arising in vulvar papillary hidradenoma: report of 2 cases.
  • Adenocarcinoma in situ rarely occurs in vulvar papillary hidradenoma.
  • We encountered 2 cases of adenocarcinoma in situ arising in a papillary hidradenoma of the vulva.
  • One tumor ulcerated the overlying epidermis.
  • On microscopic examination, the tumors showed focal features of benign hidradenoma at the periphery with transitions into areas of increasing cytologic atypia that fulfilled criteria for adenocarcinoma in situ similar to that seen in the breast.
  • One tumor showed a predominant cribriform pattern with moderate atypia and many mitoses; the other showed a mixture of cribriform and micropapillary patterns, mild atypia, and fewer mitotic figures.
  • There was no evidence of destructive invasion or desmoplasia in either tumor.
  • There was no evidence of benign ectopic breast tissue within or adjacent to the neoplasms.
  • Both patients underwent local excision with no evidence of tumor recurrence at 15 and 32 months of follow-up.
  • The fact that these tumors displayed morphologic and immunohistochemical features that resembled ductal carcinoma in situ of the breast demonstrates the close homology between papillary hidradenoma and breast epithelium.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Sweat Gland / pathology. Carcinoma in Situ / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 18580327.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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84. Souvatzidis P, Sbano P, Mandato F, Fimiani M, Castelli A: Malignant nodular hidradenoma of the skin: report of seven cases. J Eur Acad Dermatol Venereol; 2008 May;22(5):549-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant nodular hidradenoma of the skin: report of seven cases.
  • BACKGROUND: Malignant nodular hidradenoma (MNH) is an infrequent, highly malignant, primary skin tumour derived from eccrine sweat glands.
  • Survival time was inversely proportional to the size of the tumour.
  • CONCLUSIONS: MNH is an aggressive tumour and should be diagnosed and excised as early as possible.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Skin Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 18410617.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 29
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85. Ward JL, Prieto VG, Joseph A, Chevray P, Kronowitz S, Sturgis EM: Neurothekeoma. Otolaryngol Head Neck Surg; 2005 Jan;132(1):86-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Two lesions had been previously diagnosed, histologically, as leiomyosarcomas, 1 as a malignant nodular hidradenoma, and 1 as a clear cell hidradenoma.
  • CONCLUSION: Neurothekeoma is a benign neoplasm occurring usually in women and commonly in the head and neck.

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  • (PMID = 15632914.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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86. Rongioletti F, Baldari M, Carli C, Fiocca R: Squamomelanocytic tumor: a new case of a unique biphenotypic neoplasm of uncertain biological potential. J Cutan Pathol; 2009 Apr;36(4):477-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Squamomelanocytic tumor: a new case of a unique biphenotypic neoplasm of uncertain biological potential.
  • Squamomelanocytic tumor is an uncommon cutaneous neoplasm composed of an admixture of melanocytic and squamous cellular phenotypes.
  • We describe a case of this tumor in a 94-year-old man who presented with a nodule on the back.
  • This tumor represents a proliferation of two phenotypic cells that are distinctive for their intimate admixture and singular immunohistochemical profile.
  • The authors discuss the histogenesis of this tumor, suggesting that it could represent an atypical solid-cystic hidradenoma colonized by a melanocytic malignant component.
  • The biological behavior of this neoplasm remains currently uncertain.

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  • (PMID = 19278436.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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87. Möller E, Stenman G, Mandahl N, Hamberg H, Mölne L, van den Oord JJ, Brosjö O, Mertens F, Panagopoulos I: POU5F1, encoding a key regulator of stem cell pluripotency, is fused to EWSR1 in hidradenoma of the skin and mucoepidermoid carcinoma of the salivary glands. J Pathol; 2008 May;215(1):78-86
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] POU5F1, encoding a key regulator of stem cell pluripotency, is fused to EWSR1 in hidradenoma of the skin and mucoepidermoid carcinoma of the salivary glands.
  • In the present study, we report the fusion of EWSR1 and POU5F1 in two types of epithelial tumours: hidradenoma of the skin and mucoepidermoid carcinoma of the salivary glands.
  • This finding not only broadens considerably the spectrum of neoplasms associated with EWSR1 fusion genes but also strengthens the evidence for shared pathogenetic mechanisms in the development of adnexal and salivary gland tumours.
  • [MeSH-major] Adenoma, Sweat Gland / metabolism. Calmodulin-Binding Proteins / genetics. Carcinoma, Mucoepidermoid / metabolism. Octamer Transcription Factor-3 / genetics. RNA-Binding Proteins / genetics. Salivary Glands / metabolism. Skin Neoplasms / metabolism

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  • (PMID = 18338330.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Calmodulin-Binding Proteins; 0 / EWSR1 protein, human; 0 / Octamer Transcription Factor-3; 0 / Oncogene Proteins, Fusion; 0 / POU5F1 protein, human; 0 / RNA-Binding Proteins
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88. Chiu HH, Chen PH, Wu CS, Chen GS, Tsai KB, Wen CH, Lan CC: Origin of poroid hidradenoma and pigmentation mechanism of eccrine poroma: critical analysis of an unique presentation. J Eur Acad Dermatol Venereol; 2009 May;23(5):597-9
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  • [Title] Origin of poroid hidradenoma and pigmentation mechanism of eccrine poroma: critical analysis of an unique presentation.
  • [MeSH-major] Adenoma, Sweat Gland / etiology. Eccrine Glands / pathology. Skin Pigmentation

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  • (PMID = 18783473.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Endothelin-1
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89. Kim S, Lim B, Kim J: EWS-Oct-4B, an alternative EWS-Oct-4 fusion gene, is a potent oncogene linked to human epithelial tumours. Br J Cancer; 2010 Jan 19;102(2):436-46
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  • Recently, an alternative form of the fusion protein between the EWS and Oct-4 genes, named EWS-Oct-4B, was reported in two types of epithelial tumours, a hidradenoma of the skin and a mucoepidermoid carcinoma of the salivary glands.
  • [MeSH-major] Carcinoma / genetics. Octamer Transcription Factor-3 / genetics. Oncogene Proteins, Fusion / genetics. RNA-Binding Protein EWS / genetics. Salivary Gland Neoplasms / genetics. Sweat Gland Neoplasms / genetics

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  • (PMID = 20051954.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Octamer Transcription Factor-3; 0 / Oncogene Proteins, Fusion; 0 / POU5F1 protein, human; 0 / RNA-Binding Protein EWS
  • [Other-IDs] NLM/ PMC2816667
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90. Sirivella S, Gielchinsky I: Chondroid syringoma: a rare tumor of the chest wall. Ann Thorac Surg; 2010 Mar;89(3):983-5
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  • [Title] Chondroid syringoma: a rare tumor of the chest wall.
  • Chondroid syringoma, an uncommon, slow-growing, benign, sweat-gland tumor located on the upper right chest wall of a 66-year-old woman is presented.
  • This skin adenexal tumor is typically located on the head and neck region.
  • Total surgical excision remains the best therapeutic option to avoid tumor recurrence and close follow-up is recommended because of a rare possibility of malignant transformation and visceral metastases.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • [Copyright] 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20172178.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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91. Seyhan T, Borman H, Bal N: Malignant eccrine spiradenoma of the scalp. J Craniofac Surg; 2008 Nov;19(6):1608-12
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  • Malignant eccrine spiradenoma is a rare neoplasm generally arising from long-standing benign eccrine spiradenomas; it is rarely seen on the scalp.
  • A 27-year-old woman with a malignant eccrine spiradenoma of the scalp, which had occurred 8 months after the inadequate excision of a benign eccrine spiradenoma, was treated at our hospital.
  • The tumor with its large subcutaneous extension and the outer table of the cranium were removed.
  • At 24 months' follow-up, there has been no tumor recurrence.
  • We report a case of a malignant eccrine spiradenoma of the scalp with cranial involvement that arose from an inadequately removed, long-standing, benign eccrine spiradenoma in a young patient.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Head and Neck Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis. Scalp / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Alopecia / diagnosis. Female. Follow-Up Studies. Humans. Neoplasm Invasiveness. Sentinel Lymph Node Biopsy. Skin Transplantation


92. Kazakov DV, Grossmann P, Spagnolo DV, Vanecek T, Vazmitel M, Kacerovska D, Zelger B, Calonje E, Michal M: Expression of p53 and TP53 mutational analysis in malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome. Am J Dermatopathol; 2010 May;32(3):215-21
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  • We performed immunohistochemical assessment of p53 expression and TP53 mutational analysis of 15 malignant neoplasms arising from preexisting benign cylindroma, spiradenoma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome.
  • None of the 12 benign control group cases harbored a TP53 mutation, whereas all 12 demonstrated single nucleotide polymorphisms identical to those detected in the malignant tumor group.
  • In conclusion, we found a fairly high rate of p53 expression in malignant neoplasms arising from preexisting benign spiradenomas, cylindromas, and spiradenocylindromas.
  • Whereas immunostaining for p53 has been suggested as an adjunct tool to differentiate benign spiradenoma, cylindroma, and spiradenocylindroma from their malignant counterparts, its utility is limited by its heterogeneous pattern of expression, especially the sometimes lack of staining in clearly malignant areas and the occurrence of focal, weak positivity in the benign residua or in unequivocally benign neoplasms.
  • [MeSH-major] Adenoma / genetics. Carcinoma, Adenoid Cystic / genetics. Neoplasms, Multiple Primary / genetics. Point Mutation. Sweat Gland Neoplasms / genetics. Tumor Suppressor Protein p53 / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. DNA Mutational Analysis. DNA, Neoplasm / genetics. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Syndrome. Young Adult

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  • (PMID = 20075707.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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93. Chiu HH, Lan CC, Wu CS, Chen GS, Tsai KB, Chen PH: A single lesion showing features of pigmented eccrine poroma and poroid hidradenoma. J Cutan Pathol; 2008 Sep;35(9):861-5
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  • [Title] A single lesion showing features of pigmented eccrine poroma and poroid hidradenoma.
  • Poroid hidradenoma (PH) is a variant of poroma.
  • This neoplasm shows architectural characteristics of hidradenoma (tumor cells confined entirely within the dermis in both solid and cystic components) and cytologic characteristics of poroid neoplasm (poroid and cuticular cells, the latter showing ductal differentiation).
  • [MeSH-major] Acrospiroma / pathology. Pigmentation Disorders / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cell Nucleus / metabolism. Cell Nucleus / pathology. Female. Humans. Immunohistochemistry. Ki-67 Antigen / metabolism. Melanins / metabolism. Middle Aged. Pigmentation

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  • (PMID = 18422687.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Melanins
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94. van Hout NM, Hazebroek EJ, de Rooij PD: A giant atypical hidradenoma on the neck. Dermatol Surg; 2008 Oct;34(10):1411-3
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  • [Title] A giant atypical hidradenoma on the neck.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18637811.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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95. Kariya Y, Moriya T, Suzuki T, Chiba M, Ishida K, Takeyama J, Endoh M, Watanabe M, Sasano H: Sex steroid hormone receptors in human skin appendage and its neoplasms. Endocr J; 2005 Jun;52(3):317-25
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  • Therefore, in this study, we immunolocalized sex steroid receptor protein (estrogen receptor (ER)alpha, ERbeta, progesterone receptor (PR)A, PRB and androgen receptor (AR)) in 23 cases of non-pathological skin (male: 10, female: 13) and in 50 cases of skin adnexal tumors (male 24, female 26; 38 benign and 12 malignant).
  • ERalpha immunoreactivity was detected exclusively in basal cells of sebaceous glands of non-pathological skin.
  • AR and PRB immunoreactivity was detected in both differentiated and basal cells of sebaceous gland.
  • AR and ERbeta immunoreactivity was also detected in sebaceous and eccrine sweat glands but not in outer root sheath of hair follicles.
  • In sebaceous gland neoplasms, the number of ERalpha positive cases was significantly lower in skin appendage neoplasms than non-pathological skin.
  • ERbeta immunoreactivity was not detected in any of sebaceous gland neoplasms examined.
  • There were no significant differences in PRA, PRB and AR immunoreactivity between non-pathological sebaceous gland and its neoplasm.
  • In sweat gland neoplasms, the number of AR positive cases was significantly lower in benign neoplasms than their non-pathological counterpart.
  • Therefore sex steroids are considered to play important roles in regulation of non-pathological skin appendage function and pathogenesis and/or development of its neoplasm.
  • In addition, the status of the great majority of sex steroid hormone receptors was maintained throughout the process of neoplastic transformation of skin appendages, except for AR and ERalpha in sweat and sebaceous gland neoplasms.
  • [MeSH-major] Carcinoma, Skin Appendage / metabolism. Receptors, Steroid / metabolism. Sebaceous Gland Neoplasms / metabolism. Sweat Gland Neoplasms / metabolism

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  • (PMID = 16006726.001).
  • [ISSN] 0918-8959
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; 0 / Estrogen Receptor beta; 0 / Receptors, Androgen; 0 / Receptors, Progesterone; 0 / Receptors, Steroid; 0 / progesterone receptor A; 0 / progesterone receptor B
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96. Quatresooz P, Piérard GE: Distinct expression patterns of alpha1 (IV) and alpha5 (IV) collagen chains in cylindroma and malignant cylindroma. Int J Mol Med; 2005 Jan;15(1):27-31
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  • Cutaneous cylindromas are considered to derive from cells of the sweat gland apparatus.
  • The aim was to study the distribution of the alpha1 (IV) and alpha5 (IV) collagen chains in cylindromas and malignant cylindroma, and to compare it with the BM of sweat glands.
  • The malignant cylindroma showed a linear immunoreactivity for the alpha1 (IV) collagen chain undistinguishable from the pattern seen in the benign cylindromas.
  • No immunoreactivity was present for the alpha5 (IV) collagen chain in the malignant neoplasm.
  • The distinctive patterns of expression of the alpha1 (IV) and alpha5 (IV) collagen chains may be related to the histogenic sudoral origin of cylindromas without any relationship with the benign or malignant nature of the neoplasm.

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  • (PMID = 15583824.001).
  • [ISSN] 1107-3756
  • [Journal-full-title] International journal of molecular medicine
  • [ISO-abbreviation] Int. J. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Collagen Type IV
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97. Chen CC, Chang YT, Liu HN: Clinical and histological characteristics of poroid neoplasms: a study of 25 cases in Taiwan. Int J Dermatol; 2006 Jun;45(6):722-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Eccrine poroma (EP) are relatively common benign eccrine neoplasms.
  • Other poroid neoplasms (PNs), namely hidroacanthoma simplex (HS), dermal duct tumor (DDT), and poroid hidradenoma (PH), are seldom reported.
  • [MeSH-major] Skin Neoplasms / pathology. Sweat Gland Diseases / pathology

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  • (PMID = 16796636.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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98. Daniel F, Mahmoudi A, de Parades V, Fléjou JF, Atienza P: An uncommon perianal nodule: hidradenoma papilliferum. Gastroenterol Clin Biol; 2007 Feb;31(2):166-8
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  • [Title] An uncommon perianal nodule: hidradenoma papilliferum.
  • Hidradenoma papilliferum is a rare, benign, cystic, papillary apocrine gland tumor that occurs almost exclusively in women in the skin of the anogenital region.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Anus Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17347625.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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99. Gatti A, di Meo N, Trevisan G: Dermoscopy of eccrine acrospiroma masquerading as nodular malignant melanoma. Acta Dermatovenerol Alp Pannonica Adriat; 2010 Dec;19(4):23-5
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  • Eccrine acrospiroma, better known as eccrine poroma, is a benign adnexal neoplasm of the skin.
  • [MeSH-major] Acrospiroma / pathology. Dermoscopy. Melanoma / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology


100. Fullen DR, Garrisi AJ, Sanders D, Thomas D: Expression of S100A6 protein in a broad spectrum of cutaneous tumors using tissue microarrays. J Cutan Pathol; 2008 Nov;35 Suppl 2:28-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CONCLUSIONS: S100A6 expression may distinguish SCC from BCC, MAC from BCC and hidradenoma from other adnexal tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cell Cycle Proteins / biosynthesis. S100 Proteins / biosynthesis. Skin Neoplasms / diagnosis. Skin Neoplasms / metabolism

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  • (PMID = 18201235.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / S100 Proteins; 105504-00-5 / S100A6 protein, human
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