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1. Stodulski D, Rzepko R, Kowalska B, Stankiewicz C: [Carcinoma ex pleomorphic adenoma of major salivary glands--a clinicopathologic review]. Otolaryngol Pol; 2007;61(5):687-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Pleomorphic adenoma (PA) is the most common neoplasm of the major salivary glands.
  • There are three subtypes of malignant PA: carcinoma ex pleomorphic adenoma (CXPA); carcinosarcoma (true malignant mixed tumor) and metastasizing pleomorphic adenoma.
  • For proper diagnosis of CXPA, a statement of coexistence of pleomorphic adenoma and carcinoma (or carcinoma after prior PA surgery) is needed.
  • Own material is presented because of rarity and clinicopathologic specificity of this neoplasm.
  • The following clinical factors were evaluated: age, sex, symptoms (time of lasting, evolution), tumor size, invasion of the adjacent structures and facial nerve, neck nodes, clinical stage, treatment outcome.
  • One pathologist reviewed histological material of 18 out of 19 patients who had been operated and pathological factors such as sensitivity and accuracy of fine needle aspiration biopsy, grade, histology and proportion of malignant component in tumor, lymph nodes metastases were analyzed.
  • In 15 cases, tumor was localized in the parotid and in 4 in the submandibular gland.
  • Duration of symptoms of benign PA was from 2 to 40 years (mean 17.8 years).
  • Symptoms of malignant transformation occurred in 15 patients, the most common were rapid enlargement of tumor, pain and facial nerve palsy.
  • Tumor size varied from 2 to 20 cm with a mean of 6 cm.
  • Adjacent structures were invaded by neoplasm in 5 cases.
  • Clinical picture and histopathological examination determinate the diagnosis of CXPA.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma / pathology. Neoplasms, Multiple Primary / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology
  • [MeSH-minor] Biopsy, Needle. Female. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 18552001.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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2. Panikar N, Agarwal S: Salivary gland manifestations of sinus histiocytosis with massive lymphadenopathy: fine-needle aspiration cytology findings. A case report. Diagn Cytopathol; 2005 Sep;33(3):187-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Salivary gland manifestations of sinus histiocytosis with massive lymphadenopathy: fine-needle aspiration cytology findings. A case report.
  • We present the cytologic features and differential diagnoses of one such case.A 45-yr-old woman presented with an enlarged submandibular gland on the left side with ipsilateral cervical lymphadenopathy that had been persisting for 1 mo.
  • The gland and the two enlarged nodes measured 2.5 x 2.5 cm(2) each and were firm in consistency.
  • Clinically, tumor of the salivary glands was suspected.
  • The diagnosis of SHML involving left submandibular gland and ipsilateral lymph nodes was returned.
  • When analyzed in the context of clinical findings (laboratory data), the cytologic features of SHML involving salivary gland could be differentiated from those of malignancies and other benign lesions, especially Kuttner's tumor of the submandibular gland, which mimics neoplasm clinically.
  • [MeSH-major] Histiocytosis, Sinus / pathology. Salivary Gland Diseases / etiology. Salivary Gland Diseases / pathology
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Middle Aged

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  • [Copyright] Copyright (c) 2005 Wiley-Liss, Inc.
  • (PMID = 16078253.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Ethunandan M, Witton R, Hoffman G, Spedding A, Brennan PA: Atypical features in pleomorphic adenoma--a clinicopathologic study and implications for management. Int J Oral Maxillofac Surg; 2006 Jul;35(7):608-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pleomorphic adenoma is the most common salivary gland neoplasm and infrequently undergoes malignant transformation.
  • Carcinoma ex pleomorphic adenoma is typically an infiltrative neoplasm with features of cellular pleomorphism, high mitotic activity, peri-neural and vascular invasion.
  • Three tumours exhibited features of dysplasia/carcinoma without evidence of extra-capsular invasion and a further case demonstrated benign vascular invasion.
  • Patients underwent a superficial parotidectomy or submandibular gland excision based on the location of the lesion.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 16540285.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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4. Huang HZ, Huang ZQ, Zhao XP, Zhang B: [Intraoral submandibular gland excision and how to deal with external maxillary artery]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2006 Jul;41(7):514-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Intraoral submandibular gland excision and how to deal with external maxillary artery].
  • OBJECTIVE: To investigate the feasibility and safety of intraoral submandibular gland excision.
  • METHODS: Analyze the relationship between the external maxillary artery and submandibular gland, and offer a reliable anatomical base for 10 cases of intraoral submandibular gland excision, including 8 cases of chronic sialadenitis, 1 case of pleomorphic adenoma and 1 case of cyst of submandibular gland.
  • RESULTS: The external maxillary artery went across the surface of gland submandibular, and its branches provided nutrition for the gland in most cases.
  • The results of 10 cases intraoral submandibular gland excision were effective and satisfied, without major complications.
  • CONCLUSION: Intraoral submandibular gland excision is safe and feasible for chronic sialadenitis and cyst of submandibular gland and some of benign tumor submandibular gland as long as indications strictly controlled and the external maxillary artery well coped with.
  • [MeSH-major] Maxillary Artery / surgery. Submandibular Gland / anatomy & histology. Submandibular Gland / surgery. Submandibular Gland Diseases / surgery
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Middle Aged. Sialadenitis / surgery. Submandibular Gland Neoplasms / surgery. Treatment Outcome. Young Adult

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  • (PMID = 17007375.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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5. Ceylan A, Celenk F, Poyraz A, Uslu S: Pleomorphic adenoma of the nasal columella. Pathol Res Pract; 2008;204(4):273-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pleomorphic adenoma (mixed tumor) is the most common benign neoplasm of the salivary glands.
  • It is considered to occur primarily in the major salivary glands, such as the parotid and submandibular glands.
  • It is much less common in the minor salivary glands, and rarely occurs at other sites, such as larynx, pharynx, trachea, lacrimal gland, and sinonasal tract.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Neoplasm Recurrence, Local. Neoplasm Seeding. Nose Neoplasms / pathology

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  • (PMID = 18295980.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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6. Kaba S, Kojima M, Matsuda H, Sugihara S, Masawa N, Kobayashi TK, Fukuda T: Küttner's tumor of the submandibular glands: report of five cases with fine-needle aspiration cytology. Diagn Cytopathol; 2006 Sep;34(9):631-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Küttner's tumor of the submandibular glands: report of five cases with fine-needle aspiration cytology.
  • Küttner's tumor (KT) is a benign tumor-like lesion of the salivary gland that mimics neoplasm clinically because of presentation as a hard mass.
  • Recently, the histomorphological and immunohistochemical findings of this lesion have been analyzed, and differential diagnostic problems relating to salivary gland lymphoma have been discussed.
  • FNAC findings of scattered ductal structures surrounded by collagens and infiltrated by a mixed population of lymphoid cells, not specific for KT, are highly suggestive of the diagnosis with the appropriate clinical findings.
  • However, a portion of cytological specimens of KT containing relatively large numbers of lymphoid cells should be differentiated from malignant lymphoma arising from the submandibular gland.
  • [MeSH-major] Biopsy, Fine-Needle. Sialadenitis / pathology. Submandibular Gland / pathology. Submandibular Gland Diseases / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Lymphoma / pathology. Male. Middle Aged. Retrospective Studies. Salivary Ducts / pathology. Salivary Gland Neoplasms / pathology. Sclerosis / pathology. Sclerosis / surgery. Treatment Outcome

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16900478.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Folk GS, Williams SB, Foss RB, Fanburg-Smith JC: Oral and maxillofacial sclerosing epithelioid fibrosarcoma: report of five cases. Head Neck Pathol; 2007 Sep;1(1):13-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The OMF Pathology Department Registry was searched for cases coded from 1990 to the present as "SEF," "fibrosarcoma not otherwise specified" or "neoplasm of uncertain histiogenesis."
  • Tumor location included the infra-temporal fossa, buccal mucosa (recurrence extending into bone), anterior mandible (intraosseous primary, focally extending into soft tissue), and left parotid and submandibular gland (with metaplastic bone) regions.
  • Tumor sizes ranged from 1.0 to 5.7 cm, median 3.5 cm.
  • The spindled to primarily epithelioid tumor cells formed moderately cellular sheets and cords of irregularly contoured medium to large, round to oval, occasionally overlapping nuclei, indistinct nucleoli, wispy eosinophilic (retracting) cytoplasm, and distinctive cytoplasmic borders, embedded in osteoid-like stroma.
  • Immunohistochemically, the tumor cells were positive for vimentin, 1 case focally for CD34, whereas all cases were negative for S100 protein, keratins, EMA, desmin, and SMA.
  • The differential diagnosis for these tumors in this site includes sclerosing carcinoma, Ewing/PNET, osteosarcoma, osteoblastoma, and benign and malignant myoepithelial salivary gland tumors.
  • The collagen, focal spindle cell features, HPC-like vasculature, and weak focal CD34 reactivity in one case might have raised a possible relationship between OMFRSEF and low grade malignant solitary fibrous tumor, but the intraosseous propensity, epithelioid features and relative lack of CD34 make this a distinctive entity.
  • [MeSH-minor] Adult. Apoptosis. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Leiomyoma / diagnosis. Male. Middle Aged. Sclerosis. Solitary Fibrous Tumors / diagnosis. Young Adult

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  • [ErratumIn] Head Neck Pathol. 2013 Mar;7(1):103
  • (PMID = 20614275.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807507
  • [Keywords] NOTNLM ; Maxillofacial / Oral / Sarcoma / Sclerosing epithelioid fibrosarcoma
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8. Sirohi D, Sharma R, Sinha R, Suresh Menon P: Salivary gland neoplasms: an analysis of 74 cases. J Maxillofac Oral Surg; 2009 Jun;8(2):164-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Salivary gland neoplasms: an analysis of 74 cases.
  • Between 2006 and 2009, 74 cases of salivary gland neoplasms were analyzed retrospectively, of which 44 (60%) were benign and 30 (40%) malignant.
  • 61 % percent of neoplasms were in the parotid gland, 22% in the minor salivary glands including sublingual salivary glands, and 17% in the submandibular glands.
  • The most common benign neoplasm was pleomorphic adenoma (64%), and the most common malignant neoplasm were adenoid cystic carcinoma (17%) and mucoepidermoid carcinoma (23%).
  • We analyze the incidence and distribution of all types of salivary gland neoplasms in our series, and provide data for comparison with other epidemiological studies from different geographical sites and races.
  • Further epidemiological surveys should be encouraged for better understanding of the disease and to provide early and better treatment of salivary gland neoplasms.

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  • (PMID = 23139498.001).
  • [ISSN] 0972-8279
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3453927
  • [Keywords] NOTNLM ; Parotid / Pleomorphic adenoma / Sublingual / Submandibular / mucoepidermoid carcinoma
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9. Wierzbicka M, Kopeć T, Szyfter W, Bem G: [Epidemiology of non-malignant salivary gland tumours based on 675 cases]. Otolaryngol Pol; 2010 Sep-Oct;64(5):281-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Epidemiology of non-malignant salivary gland tumours based on 675 cases].
  • Neoplasm of salivary glands constitutes about 3% of all tumours of head and neck.
  • About 80% of all tumours of salivary glands is located in parotid gland, from 10 to 20% - in submandibular gland and several percent in sublingual and small salivary gland.
  • This work aims at the assessment of the frequency of occurrence of non-malignant neoplasm in parotid and submandibular gland based on the material collected at the ENT Department of the Medical University in Poznan in the years 1995-2006.
  • The number of non-malignant neoplasm was 675, and the number of malignant neoplasm was 103.
  • With regard to paroid glands, 586 non-malignant tumours and 82 malignant tumours were identified, with regard to submandibular glands the numbers were respectively: 89 and 21.
  • Main aim of this work has been achieved through the execution of partial steps: the analysis of the trends in occurrence of non-malignant neoplasm in the 12-year period, the analysis of the epidemiological differences: sex, age, place of residence - town or country, duration of symptoms, diameter of the tumour at the time the patient reported for treatment, histological structures that were carried on the basis of the comparison of data collected in the two periods of time: period I--the years 1995-2000 and period II--the years 2001-2006.
  • In both periods the most frequent benign tumour was the mixed tumour (54.9% of all tumours) and constituted 60% and 54% of all tumours in the respective periods analyzed.
  • The next most frequently occurring tumour was Warthin's tumour, identified in 31.2% of the patients, in 23% in period I and 35% in period II.
  • Duration of the symptoms, ranged from 1 month to 20 years, 14 months on average, yet in 263 cases the tumour has been developing developed for over a year.
  • [MeSH-major] Rural Population / statistics & numerical data. Salivary Gland Diseases / epidemiology. Salivary Gland Diseases / pathology. Urban Population / statistics & numerical data
  • [MeSH-minor] Adult. Age Distribution. Age Factors. Aged. Female. Humans. Incidence. Male. Middle Aged. Neoplasm Staging. Poland / epidemiology. Prognosis. Salivary Gland Neoplasms / epidemiology. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology. Young Adult

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  • (PMID = 21166137.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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10. Alves CA, Ribeiro Júnior O, Borba AM, Gouveia MM, Guimarães Júnior J, Aburad A, de Souza SC: Pleomorphic multicentric adenoma in the submandibular gland. Head Neck Pathol; 2007 Dec;1(2):178-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pleomorphic multicentric adenoma in the submandibular gland.
  • In this group, the pleomorphic adenoma is the most frequent neoplasm, yet involves the submandibular gland in only 12.3% of cases.
  • A patient presenting a swelling in the region of the submandibular gland was submitted to an incisional biopsy, where a fragment of the gland and one juxtaposed node were removed.
  • Later, the patient was submitted to submandibulectomy and two other nodes were found close to the gland and removed.
  • This multicentric finding is of great interest, perhaps explaining the recurrence rate of this neoplasm.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Submandibular Gland / pathology. Submandibular Gland Neoplasms / pathology

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  • (PMID = 20614272.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807518
  • [Keywords] NOTNLM ; Benign neoplasm / Multicentric tumor / Pleomorphic adenoma / Salivary gland tumor / Submandibular gland
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11. Freitas LL, Araújo VC, Martins MT, Chone C, Crespo A, Altemani A: Biomarker analysis in carcinoma ex pleomorphic adenoma at an early phase of carcinomatous transformation. Int J Surg Pathol; 2005 Oct;13(4):337-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In all cases of CXPA, p53 and Ki-67 were demonstrated predominantly in luminal cells of benign and malignant areas, significantly more in the latter.
  • Few benign myoepithelial cells were p53 positive. c-erbB-2 reactivity was strongly associated with atypical luminal cells.
  • In PA with atypical cells, evaluation of the expression of these 2 markers provides more objective criteria for the diagnosis of intracapsular CXPA.
  • [MeSH-major] Adenoma, Pleomorphic / chemistry. Biomarkers, Tumor / analysis. Cell Transformation, Neoplastic. Parotid Neoplasms / chemistry. Submandibular Gland Neoplasms / chemistry
  • [MeSH-minor] Adult. Aged. Female. Humans. Immunohistochemistry. Ki-67 Antigen / analysis. Male. Middle Aged. Neoplasm Staging. Proto-Oncogene Proteins c-bcl-2 / analysis. Receptor, ErbB-2 / analysis. Receptor, ErbB-2 / physiology. Tumor Suppressor Protein p53 / analysis. Tumor Suppressor Protein p53 / physiology

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  • (PMID = 16273189.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Receptor, ErbB-2
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12. Paul R, Shekar K, Singh M: Kuttner tumour: an unusual cause of enlargement of a minor salivary gland in the lip. Br J Oral Maxillofac Surg; 2010 Mar;48(2):152-3
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  • [Title] Kuttner tumour: an unusual cause of enlargement of a minor salivary gland in the lip.
  • Kuttner tumour is benign, chronic, sclerosing sialadenitis that usually occurs in the submandibular gland and is regarded as a salivary gland neoplasm because of its clinical features.
  • We describe a tumour arising from a minor salivary gland of the upper lip.
  • [MeSH-major] Lip Neoplasms / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology
  • [MeSH-minor] Chronic Disease. Diagnosis, Differential. Female. Humans. Middle Aged. Sialadenitis / diagnosis. Sialadenitis / etiology

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  • (PMID = 19926183.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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13. Mortensen KS, Hjortlund J, Bjørndal K, Krogdal A, Godballe C: [Salivary gland tumors in the County of Funen, 1984-2003]. Ugeskr Laeger; 2008 Feb 11;170(7):545-8
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  • [Title] [Salivary gland tumors in the County of Funen, 1984-2003].
  • INTRODUCTION: The objective of this study is to estimate the incidence of major salivary gland tumors in a geographically well-defined area (the County of Funen, Denmark) and to analyse the demographic data and distribution of histological types.
  • MATERIALS AND METHODS: Patients with salivary gland tumors were identified through a search on pathology and diagnosis codes in the period 1984-2003, which initially resulted in a group of 951 patients.
  • RESULTS: The incidence of major salivary gland tumors for the County of Funen is calculated to 7.3 per 100,000 residents per year.
  • 90% of the tumors were found in the parotid gland - 93% benign and 7% malignant.
  • 10% were located in the submandibular gland - 73% benign and 27% malignant.
  • Only one neoplasm was located in the sublingual gland and it was malignant (100%).
  • CONCLUSION: The incidence of major salivary gland tumors in the County of Funen is calculated to 7.3 per 100,000 inhabitants per year which is equivalent to 383 new cases in Denmark per year.
  • [MeSH-major] Adenolymphoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Salivary Gland Neoplasms / epidemiology

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  • (PMID = 18291086.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Denmark
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14. Ellies M, Schaffranietz F, Arglebe C, Laskawi R: Tumors of the salivary glands in childhood and adolescence. J Oral Maxillofac Surg; 2006 Jul;64(7):1049-58
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  • PURPOSE: We report on 52 juvenile and adolescent patients with benign and malignant tumors of the salivary glands.
  • RESULTS: Benign tumors had their highest incidence in puberty and postpuberty.
  • Forty patients (20 girls and 20 boys; 77%) had benign growths and 12 patients (9 girls and 3 boys; 23%) suffered from malignant neoplasms.
  • After surgery for benign tumors we saw no postoperative recurrences in long-term follow-up.
  • CONCLUSIONS: Salivary gland diseases are rare in childhood and adolescence.
  • This is particularly true for the malignant parotid tumors that are more frequent in juvenile patients, a fact that has to be considered in diagnosis and therapy.
  • [MeSH-major] Adenoma, Pleomorphic / therapy. Carcinoma / therapy. Neoplasm Recurrence, Local / therapy. Salivary Gland Neoplasms / therapy
  • [MeSH-minor] Adolescent. Age Factors. Child. Female. Follow-Up Studies. Humans. Male. Parotid Neoplasms / diagnosis. Parotid Neoplasms / epidemiology. Parotid Neoplasms / pathology. Parotid Neoplasms / therapy. Submandibular Gland Neoplasms / diagnosis. Submandibular Gland Neoplasms / epidemiology. Submandibular Gland Neoplasms / pathology. Submandibular Gland Neoplasms / therapy. Survival Analysis. Treatment Outcome

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  • (PMID = 16781337.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Sivakumar S: Pilomatrixoma as a diagnostic pitfall in fine needle aspiration cytology: a case report. Acta Cytol; 2007 Jul-Aug;51(4):583-5
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  • BACKGROUND: Pilomatrixoma (pilomatrixoma, calcifying epithelioma of Malherbe) is a relatively uncommon, benign neoplasm arising from the skin adnexa.
  • The tumor can cause diagnostic difficulty not only for the clinician but also for the cytologist.
  • CASE: A 62-year-old woman presented with a right submandibular swelling of 4 months' duration.
  • Three preliminary differential diagnoses were offered: mucoepidermoid carcinoma of the submandibular salivary gland, squamous cell carcinomatous deposit in a submandibular lymph node and calcifying odontogenic tumor.
  • An excisional biopsy of the swelling was performed, and the histologic diagnosis of pilomatrixoma was made.
  • CONCLUSION: The cytologic presentation of pilomatrixoma of the right submandibular region can masquerade as that of a malignant tumor, in this case mucoepidermoid carcinoma, squamous cell carcinoma or odontogenic tumor.
  • [MeSH-major] Hair Diseases / diagnosis. Hair Diseases / pathology. Pilomatrixoma / diagnosis. Pilomatrixoma / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology

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  • (PMID = 17718128.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Williams SB, Ellis GL, Warnock GR: Sialoblastoma: a clinicopathologic and immunohistochemical study of 7 cases. Ann Diagn Pathol; 2006 Dec;10(6):320-6
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  • Sialoblastoma is a rare congenital or perinatal salivary tumor that varies in histologic features and biologic potential.
  • Five lesions originated from the parotid gland; 2 lesions were from the submandibular gland.
  • (1) a favorable pattern had semiencapsulation of cytologically benign basaloid tumor cells with intervening stroma; and (2) an unfavorable histology of anaplastic basaloid tumor cells, minimal stroma, and broad pushing to infiltrative periphery.
  • Tumor cells in 3 cases were immunohistochemically reactive for keratin, S-100, smooth muscle actin, and calponin to varying degrees.
  • Ki67 was expressed at 3% in a favorable tumor and 40% and 80% in the 2 unfavorable lesions.
  • [MeSH-major] Mixed Tumor, Malignant / secondary. Neoplasms, Glandular and Epithelial / secondary. Parotid Neoplasms / pathology. Submandibular Gland Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Female. Humans. Immunoenzyme Techniques. Infant. Infant, Newborn. Ki-67 Antigen / analysis. Male. Neoplasm Recurrence, Local. Treatment Outcome. alpha-Fetoproteins / analysis

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  • (PMID = 17126248.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / alpha-Fetoproteins
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17. Chen YK, Su CT, Chi KH, Cheng RH, Wang SC, Hsu CH: Utility of 18F-FDG PET/CT uptake patterns in Waldeyer's ring for differentiating benign from malignant lesions in lateral pharyngeal recess of nasopharynx. J Nucl Med; 2007 Jan;48(1):8-14
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  • [Title] Utility of 18F-FDG PET/CT uptake patterns in Waldeyer's ring for differentiating benign from malignant lesions in lateral pharyngeal recess of nasopharynx.
  • Focally increased (18)F-FDG uptake in the lateral pharyngeal recess (LPR) of the nasopharynx due to a benign or malignant lesion is not an uncommon finding on PET images.
  • The aim of this study was to evaluate whether, on PET/CT images, (18)F-FDG uptake occurs with characteristic patterns and intensities in various regions of Waldeyer's ring that can improve our ability to differentiate benign from malignant lesions.
  • Increased uptake in the LPR was observed in 80 subjects (4.9%) presenting with benign lesions, including 53 subjects without and 27 subjects with symptoms of upper airway discomfort.
  • RESULTS: Increased (18)F-FDG uptake (SUV, mean +/- SD) was found in the LPR, with a statistically significant (P < 0.001) difference between benign lesions (3.0 +/- 1.16) and malignant lesions (7.03 +/- 3.83).
  • However, associated increased uptake exclusively in the palatine tonsil, lingual tonsil, and submandibular gland was found in both asymptomatic and symptomatic subjects.
  • The ratio of LPR uptake to palatine tonsil uptake (N/P ratio) in benign lesions (0.81 +/- 0.37) was significantly (P < 0.001) lower than that in malignant lesions (2.30 +/- 1.62).
  • When an SUV of less than 3.9 and an N/P ratio of less than 1.5 were used as cutoff points in subjects showing the combination of symmetric uptake in the LPR and normal or symmetric wall thickening, and detectable lymph node uptake, the area under the curve for benign lesions on PET/CT was 0.932 +/- 0.042 (95% confidence interval, 0.86-0.98), with a sensitivity of 90.4% and a specificity of 93.8%.
  • CONCLUSION: The intensity and patterns of (18)F-FDG uptake in various regions of Waldeyer's ring along with CT scan findings provide a feasible modality to differentiate benign from malignant nasopharyngeal lesions.
  • [MeSH-major] Fluorodeoxyglucose F18. Nasopharyngeal Neoplasms / diagnosis. Nasopharyngeal Neoplasms / radionuclide imaging. Nasopharynx / radionuclide imaging
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Image Interpretation, Computer-Assisted. Lymph Nodes / pathology. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Metastasis. Positron-Emission Tomography / methods. Prospective Studies. Subtraction Technique

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  • (PMID = 17204693.001).
  • [ISSN] 0161-5505
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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18. Harimaya A, Somekawa Y, Sasaki M, Ohuchi T: Cystadenocarcinoma (papillary cystadenocarcinoma) of the submandibular gland. J Laryngol Otol; 2006 Dec;120(12):1077-80
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  • [Title] Cystadenocarcinoma (papillary cystadenocarcinoma) of the submandibular gland.
  • Cystadenocarcinoma (papillary cystadenocarcinoma) of the salivary gland is a rare malignant neoplasm.
  • Major locations of this neoplasm are the parotid gland, the sublingual gland, and minor salivary glands, while occurrence in the submandibular gland is extremely rare.
  • As far as we know, only one report, written in the French language, has been published concerning cystadenocarcinoma of the submandibular gland, but no report is available in the English language.
  • In this report, we describe a case of cystadenocarcinoma arising from the submandibular gland of a 54-year-old male patient.
  • The neoplasm is a low-grade carcinoma, and pre-operative examination may not show typical characteristics of malignant neoplasms.
  • Therefore, as was true in this case, the differential diagnosis from benign lesions is sometimes difficult.
  • This is the first report on cystadenocarcinoma of the submandibular gland in the English language and the first to show a computed tomography (CT) scan and magnetic resonance imaging (MRI) of this neoplasm in the submandibular gland.
  • [MeSH-major] Cystadenocarcinoma, Papillary / pathology. Submandibular Gland Neoplasms / pathology

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  • (PMID = 16995970.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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19. Jang YW, Kim SG, Pai H, Park JW, Lee YC, Rotaru H: Sialolipoma: case report and review of 27 cases. Oral Maxillofac Surg; 2009 Jun;13(2):109-13
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  • INTRODUCTION: This article presents a patient with sialolipoma of the submandibular gland, a rare neoplasm, and reviews related literatures.
  • DISCUSSION: We presented a sialolipoma of the submandibular gland and other 27 cases from published literatures.
  • It was the second case of submandibular gland sialolipoma reported in the English literature.
  • The most common site for the tumor was the parotid gland (17 cases, 60.7%), followed by the palate (four cases, 14.2%).
  • Histopathologically, a tumor was a benign lesion with proliferating lipocytes including scattered foci with a normal salivary gland tissue.
  • CONCLUSION: Sialolipoma is a rare benign neoplasm in the head and neck and it shows equal sex predilection.
  • [MeSH-major] Lipoma / diagnosis. Submandibular Gland Neoplasms / diagnosis
  • [MeSH-minor] Adipocytes / pathology. Female. Follow-Up Studies. Humans. Middle Aged. Salivary Ducts / pathology. Submandibular Gland / pathology. Tomography, X-Ray Computed

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  • (PMID = 19347375.001).
  • [ISSN] 1865-1550
  • [Journal-full-title] Oral and maxillofacial surgery
  • [ISO-abbreviation] Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 16
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20. Ziglinas P, Arnold A, Arnold M, Zbären P: Primary tumors of the submandibular glands: a retrospective study based on 41 cases. Oral Oncol; 2010 Apr;46(4):287-91
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  • [Title] Primary tumors of the submandibular glands: a retrospective study based on 41 cases.
  • We report our experience on the diagnostic approach, treatment, and follow-up of primary submandibular gland tumors.
  • Forty-one adult patients, 22 male and 19 female, with primary submandibular gland tumors, 20 benign and 21 malignant.
  • Most tumors presented as a painless submandibular mass.
  • Patients with benign tumors were treated with surgery.
  • The preoperative assessment of the nature of submandibular gland tumors remains challenging.
  • [MeSH-major] Submandibular Gland Neoplasms / pathology
  • [MeSH-minor] Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / therapy. Adenoma, Pleomorphic / pathology. Adenoma, Pleomorphic / therapy. Aged. Biopsy, Fine-Needle. Combined Modality Therapy / methods. Cystadenoma / pathology. Cystadenoma / therapy. Female. Humans. Male. Middle Aged. Myoepithelioma / pathology. Myoepithelioma / therapy. Neck Dissection. Neoplasm Recurrence, Local / pathology. Preoperative Care. Prognosis. Retrospective Studies. Treatment Outcome

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20189445.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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21. Lü BJ, Zhu J, Gao L, Xie L, Xu JY, Lai MD: [Diagnostic accuracy and pitfalls in fine needle aspiration cytology of salivary glands: a study of 113 cases]. Zhonghua Bing Li Xue Za Zhi; 2005 Nov;34(11):706-10
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  • OBJECTIVE: To describe the fine needle aspiration cytology (FNAC) features of various salivary gland lesions and to analyze the respective diagnostic value and pitfalls.
  • METHODS: 113 FNAC specimens of salivary gland lesions were reviewed and correlated with clinical and histopathologic findings.
  • RESULTS: The FNAC diagnostic failure (2); non-neoplastic lesions (12); benign neoplasm (82) and malignant neoplasm (17).
  • The three inaccurately diagnosed cases of FNAC are, as follows: reactive lymphoid hyperplasia of lymph node mistaken as non-Hodgkin lymphoma, mucoepidermoid carcinoma diagnosed as "scanty atypical cells present" and primary lymphoepithelial carcinoma mistaken as benign lymphoepithelial lesion.
  • On the basis of FNAC, 97.4% (110 /113) were correctly depicted as benign (95/96; 99.0%) or malignant (15/17; 88.2%).
  • Furthermore, 90.3% (102 /113) (specificity = 91.9%; 102/111) were accurately diagnosed, including 91.7% (88/96) benign lesions (specificity = 92.6% ; 88/95) and 82.4% (14/17) malignant tumors (specificity = 87.5%; 14/16).
  • CONCLUSIONS: FNAC is reliable in distinguishing benign and malignant salivary gland lesions.
  • A specific cytologic diagnosis is often possible.
  • On the other hand, due to the pitfalls in cytologic diagnosis of certain salivary gland tumors, tissue biopsy for histologic examination may be necessary.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Carcinoma, Squamous Cell / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology
  • [MeSH-minor] Adenolymphoma / pathology. Adenoma / pathology. Adenoma, Pleomorphic / pathology. Adolescent. Adult. Aged. Biopsy, Fine-Needle. Carcinoma, Adenoid Cystic / pathology. Child. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Male. Middle Aged. Parotid Neoplasms / pathology. Retrospective Studies. Submandibular Gland Neoplasms / pathology

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  • (PMID = 16536312.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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22. Shigeishi H, Mizuta K, Higashikawa K, Yoneda S, Ono S, Kamata N: Correlation of CENP-F gene expression with tumor-proliferating activity in human salivary gland tumors. Oral Oncol; 2005 Aug;41(7):716-22
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  • [Title] Correlation of CENP-F gene expression with tumor-proliferating activity in human salivary gland tumors.
  • We examined the expression of Centromere protein F (CENP-F) mRNA in 26 human salivary gland tumors (seven pleomorphic adenomas, three Warthin tumors, seven mucoepidermoid carcinomas, four adenoid cystic carcinomas, four acinic cell carcinomas and one malignant myoepithelioma) and four normal submandibular glands using the real time quantitative reverse transcription-polymerase chain reaction (RT-PCR).
  • The mean expression level of CENP-F mRNA was higher in malignant tumors (1.05+/-0.32) than normal submandibular glands (0.11+/-0.05) and benign tumors (0.46+/-0.16).
  • [MeSH-major] Adenoma / genetics. Chromosomal Proteins, Non-Histone / genetics. Gene Expression Regulation, Neoplastic / genetics. Salivary Gland Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Proliferation. Female. Humans. Male. Microfilament Proteins. Middle Aged. RNA, Messenger / metabolism. RNA, Neoplasm / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Submandibular Gland / metabolism

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  • (PMID = 15927522.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / Microfilament Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / centromere protein F
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23. Hong KH, Yang YS: Intraoral approach for the treatment of submandibular salivary gland mixed tumors. Oral Oncol; 2008 May;44(5):491-5
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  • [Title] Intraoral approach for the treatment of submandibular salivary gland mixed tumors.
  • Pleomorphic adenoma represents a most common benign neoplasm of major salivary glands.
  • Most occurrences of this benign tumor in the submandibular gland have been treated surgically without difficulty via transcervical approach.
  • In this study, we introduced the intraoral approach for the removal of the submandibular mixed tumor.
  • In total, 12 cases of pleomorphic adenoma of the submandibular gland were treated via intraoral approach.
  • During surgery the tumor and submandibular gland are easily dissected from surrounding tissue and removed through intraoral incision.
  • All patients were followed up for the recurrence of the tumor from 20 months to 10 years.
  • One patient showed a tumor recurrence at the early stage of this approach.
  • We propose that the benign mixed tumor of the submandibular gland could be removed easily via intraoral route without an external scar or nerve injury.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Postoperative Complications / prevention & control. Submandibular Gland / surgery. Submandibular Gland Neoplasms / surgery

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  • (PMID = 17827052.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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24. Tagnon B, Weynand B, Reychler H: Küttner's tumour: a case report. Acta Chir Belg; 2008 Sep-Oct;108(5):621-4
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  • [Title] Küttner's tumour: a case report.
  • Küttner's tumour (chronic sclerosing sialadenitis) is a chronic inflammatory disease of the salivary glands.
  • It is a totally benign lesion.
  • However, because of its clinical features, the clinical diagnosis is often that of a salivary gland neoplasm.
  • We present a case of unilateral Küttner's tumour in the left submandibular salivary gland and discuss clinical, imaging and histological features.
  • [MeSH-major] Sialadenitis / diagnosis. Submandibular Gland / pathology. Submandibular Gland Diseases / diagnosis

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  • (PMID = 19051485.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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25. Roh JL, Park CI: Gland-preserving surgery for pleomorphic adenoma in the submandibular gland. Br J Surg; 2008 Oct;95(10):1252-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gland-preserving surgery for pleomorphic adenoma in the submandibular gland.
  • BACKGROUND: Removal of tumours arising in the submandibular gland (SMG) usually involves excision of the entire gland.
  • This prospective study evaluated the efficacy of gland-preserving surgery in patients with benign SMG tumours.
  • METHODS: Twenty consecutive patients with pleomorphic adenomas in the SMG underwent local excision of tumours with limited tumour-free margins and preservation of the remnant glandular tissues.
  • Complications, operating time, salivary function and rates of tumour recurrence were evaluated.
  • After surgery, the function of the affected gland was equal to that of the unaffected gland.
  • All patients had symmetrical facial contours without defects in the operated submandibular triangle.
  • None of the patients had evidence of tumour recurrence on ultrasonographic examination and regular clinical examination at a median of 36 months after surgery.
  • CONCLUSION: Gland-preserving surgery in patients with benign SMG tumours preserves salivation, and reduces surgical morbidity and operating time, with good cosmesis but without compromising local control.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Submandibular Gland / surgery. Submandibular Gland Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Length of Stay. Male. Middle Aged. Neoplasm Recurrence, Local. Prospective Studies. Saliva / secretion

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  • (PMID = 18720459.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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26. Zhi KQ, Ren WH, Zhang L, Wen YM, Zhang YC: [Diagnosis and surgical approach of parapharyngeal space neoplasms]. Shanghai Kou Qiang Yi Xue; 2007 Oct;16(5):547-50
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  • [Title] [Diagnosis and surgical approach of parapharyngeal space neoplasms].
  • PURPOSE: The aim of this study is to investigate the diagnosis and reasonable surgical approach for parapharyngeal space neoplasms.
  • Most patients visited the doctor with cervical or submandibular masses and some of them with disorders of swallowing or speech.
  • 87.5% of the neoplasms were benign and 12.5% were malignant.
  • Neurogenic tumors and tumors originating from the parotid gland accounted the most.
  • CT or MRI provided useful information such as their sizes, shapes, extents and the relationship between the neoplasm and surrounding tissues.
  • CONCLUSIONS: CT and/or MRI are essentially useful tools for diagnosis and presurgical planning.
  • [MeSH-minor] Humans. Mandible / surgery. Parotid Gland / surgery. Pharynx / surgery. Retrospective Studies

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  • (PMID = 18004491.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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27. Shigeishi H, Yoneda S, Taki M, Nobumori T, Ohta K, Higashikawa K, Yasui W, Kamata N: Correlation of human Bub1 expression with tumor-proliferating activity in salivary gland tumors. Oncol Rep; 2006 Apr;15(4):933-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Correlation of human Bub1 expression with tumor-proliferating activity in salivary gland tumors.
  • We examined the expression of Bub1 mRNA and protein in 21 human salivary gland tumors (7 pleomorphic adenomas, 2 warthin tumors, 5 mucoepidermoid carcinomas, 3 adenoid cystic carcinomas and 4 acinic cell carcinomas) and 3 normal submandibular glands using real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) or western blotting.
  • The mean expression levels of Bub1 mRNA and protein were higher in malignant tumors (0.12+/-0.028/1.75+/-0.53) than normal submandibular glands (0.042+/-0.014/0.19+/-0.044) and benign tumors (0.058+/-0.01/0.97+/-0.44).
  • A significant correlation was found between Bub1 mRNA/protein expression and the Ki-67 labeling index in salivary gland tumors (Spearman's correlation coefficient by rank test, p=0.026/p=0.002).
  • [MeSH-major] Cell Proliferation. Protein Kinases / genetics. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adenolymphoma / genetics. Adenolymphoma / metabolism. Adenolymphoma / pathology. Adenoma, Pleomorphic / genetics. Adenoma, Pleomorphic / metabolism. Adenoma, Pleomorphic / pathology. Blotting, Western. Carcinoma, Acinar Cell / genetics. Carcinoma, Acinar Cell / metabolism. Carcinoma, Acinar Cell / pathology. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / genetics. Carcinoma, Mucoepidermoid / metabolism. Carcinoma, Mucoepidermoid / pathology. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Ki-67 Antigen / analysis. Neoplasm Staging. Proliferating Cell Nuclear Antigen / analysis. Protein-Serine-Threonine Kinases. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16525682.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen; 0 / RNA, Messenger; EC 2.7.- / Protein Kinases; EC 2.7.11.1 / BUB1 protein, human; EC 2.7.11.1 / Bub1 spindle checkpoint protein; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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28. Kubacka M, Pośpiech L, Jaworska M, Markowska-Woyciechowska A: [A case of bilateral oncocytomas of the submandibular gland and synchronous renal oncocytomas]. Otolaryngol Pol; 2005;59(6):903-5
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  • [Title] [A case of bilateral oncocytomas of the submandibular gland and synchronous renal oncocytomas].
  • A case of 42 years-old man with bilateral big sized (12 x 5 cm and 10 x 4,5 cm) oncocytoma in submandibular glands was presented.
  • Oncocytoma is a rare benign neoplasm observed in numerous of organs.
  • In the case described besides submandibular glands tumours, accessory oncocytic tumours in both kidneys were diagnosed.
  • The comparison of the both tumours histology allowed to establish proper diagnosis.
  • The case is presented because of the explicitly of the oncocytoma location especially in the both submandibular glands simultaneously with tumour of the same histology in distant organs.
  • [MeSH-major] Adenoma, Oxyphilic / complications. Kidney Neoplasms / complications. Neoplasms, Multiple Primary. Submandibular Gland Neoplasms / complications
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male

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  • (PMID = 16521462.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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29. Suwała P, Wilczyński K, Barnaś S, Pitala G: [Salivary tumors in the material of the Otolaryngology Clinical Ward of 4th Military Clinical Hospital with the Polyclinic in Wrocław in the years 1992- 2008]. Otolaryngol Pol; 2009 Sep;63(7):54-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIM: The aim of the study is the analyses of salivary gland tumors on 193 patients who underwent surgery at the Otolaryngology Clinical Ward of 4th Military Clinical Hospital with the Polyclinic in Wrocław in the years 1992-2008.
  • MATERIAL AND METHODS: In the group of patients with salivary gland tumors, which were analysed, there were 106 woman (54.9%) and 87 men (45.1%).
  • RESULTS AND CONCLUSIONS: Tumors located in 48.7% in parotid gland, 49.7% in submandibular salivary gland and 1.6% in hypoglossal salivary gland.
  • Tumor--like lesions constituted 56%, adenoma 38.9% and malignat tumors 4.7% of all glands tumors.
  • Tumors salivary glands both benign and malignat occur at women about the average age of 50.9 more often.
  • Pleomorphic adenoma was the most common neoplasm.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenocarcinoma / surgery. Adenoma / epidemiology. Adenoma / surgery. Salivary Gland Neoplasms / epidemiology. Salivary Gland Neoplasms / surgery
  • [MeSH-minor] Adenoma, Pleomorphic / epidemiology. Adenoma, Pleomorphic / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Mucoepidermoid / epidemiology. Carcinoma, Mucoepidermoid / surgery. Female. Follow-Up Studies. Hospitals, Military. Humans. Male. Middle Aged. Parotid Neoplasms / epidemiology. Parotid Neoplasms / surgery. Poland / epidemiology. Retrospective Studies. Salivary Glands / surgery. Sex Distribution. Submandibular Gland Neoplasms / epidemiology. Submandibular Gland Neoplasms / surgery. Survival Analysis. Treatment Outcome. Young Adult

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  • (PMID = 20564902.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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