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1. Muenscher A, Diegel T, Jaehne M, Ussmüller J, Koops S, Sanchez-Hanke M: Benign and malignant salivary gland diseases in children A retrospective study of 549 cases from the Salivary Gland Registry, Hamburg. Auris Nasus Larynx; 2009 Jun;36(3):326-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign and malignant salivary gland diseases in children A retrospective study of 549 cases from the Salivary Gland Registry, Hamburg.
  • OBJECTIVE: Tumors of salivary glands in children are rare.
  • Basically all types of salivary gland diseases during the period of childhood are described.
  • The incidences of salivary gland tumors in children (0-14 years) differ completely from those in adults.
  • METHODS: In our study we were able to draw data from the Hamburg Salivary Gland Registry, concerning the last 25 years regarding histopathological diagnosis, age, gender and localisation of the pathologies.
  • As a reference centre for salivary gland diseases some material was sent by other institutions.
  • RESULTS: This study will give a detailed survey of salivary gland diseases and tumors in children up to the age of 14 which have undergone surgical therapy/biopsy.
  • Comparing the distribution of malignant tumors with other studies, the epithelial-myoepithelial carcinomas followed by salivary duct carcinomas represent the largest group in childhood.
  • Further many salivary gland diseases in childhood underwent surgery/biopsy although this is not supposed to be the proper treatment.
  • The study shows that the right diagnosis most often can only be reached by surgery and histology.
  • [MeSH-major] Registries. Salivary Gland Neoplasms / epidemiology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adolescent. Biopsy. Catchment Area (Health). Child. Child, Preschool. Female. Germany / epidemiology. Humans. Infant. Infant, Newborn. Male. Neoplasm Staging. Retrospective Studies

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  • (PMID = 18809268.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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2. Ilie M, Hofman V, Pedeutour F, Attias R, Santini J, Hofman P: Oncocytic lipoadenoma of the parotid gland: Immunohistochemical and cytogenetic analysis. Pathol Res Pract; 2010 Jan 15;206(1):66-72
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  • [Title] Oncocytic lipoadenoma of the parotid gland: Immunohistochemical and cytogenetic analysis.
  • Salivary gland oncocytic lipoadenoma is an exceptional benign tumor composed of mature adipose tissue associated with a mixture of oncocytes.
  • A 64-year-old male developed a left parotid gland, well-encapsulated tumor measuring 3.5 x 3 cm(2), showing mature fat cells associated with oncocytic changes of epithelial components.
  • Such alterations in HMGA2 have been described in both lipomas and pleomorphic adenomas of the salivary glands.
  • [MeSH-minor] Disease-Free Survival. Humans. Immunohistochemistry. Lipoma / metabolism. Lipoma / pathology. Lipoma / surgery. Male. Middle Aged. Neoplasm Proteins / metabolism

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  • [Copyright] Copyright 2009 Elsevier GmbH. All rights reserved.
  • (PMID = 19346081.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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3. Chahwala Q, Siddaraju N, Singh N, Goneppanavar M, Basu D: Fine needle aspiration cytology of oncocytic lipoadenoma of the parotid gland: report of a rare case. Acta Cytol; 2009 Jul-Aug;53(4):437-9
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  • [Title] Fine needle aspiration cytology of oncocytic lipoadenoma of the parotid gland: report of a rare case.
  • BACKGROUND: Oncocytic lipoadenoma is an uncommon benign salivary gland tumor.
  • CASE: A 50-year-old woman presented with a slow-growing swelling in the left parotid region that was clinically interpreted as a soft tissue tumor, with a differential of neurofibroma/lipoma.
  • The adipose tissue background of the cytologic smears was ignored as material derived from the normal fat tissue; based on the oncocytic population of cells, a diagnosis of oncocytoma was considered.
  • However, histopathologic examination showed it to be an oncocytic lipoadenoma, a tumor we were unaware of at the time of cytodiagnosis.
  • CONCLUSION: Both cytopathologists and histopathologists need to be aware of oncocytic lipoadenoma of the salivary gland in order to diagnose it precisely.
  • The clinicocytopathologic correlation highlighted in our case will be useful for cytopathologists in preoperative interpretation and diagnosis.

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  • (PMID = 19697732.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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4. Sivakumar S: Pilomatrixoma as a diagnostic pitfall in fine needle aspiration cytology: a case report. Acta Cytol; 2007 Jul-Aug;51(4):583-5
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  • BACKGROUND: Pilomatrixoma (pilomatrixoma, calcifying epithelioma of Malherbe) is a relatively uncommon, benign neoplasm arising from the skin adnexa.
  • The tumor can cause diagnostic difficulty not only for the clinician but also for the cytologist.
  • Three preliminary differential diagnoses were offered: mucoepidermoid carcinoma of the submandibular salivary gland, squamous cell carcinomatous deposit in a submandibular lymph node and calcifying odontogenic tumor.
  • An excisional biopsy of the swelling was performed, and the histologic diagnosis of pilomatrixoma was made.
  • CONCLUSION: The cytologic presentation of pilomatrixoma of the right submandibular region can masquerade as that of a malignant tumor, in this case mucoepidermoid carcinoma, squamous cell carcinoma or odontogenic tumor.
  • [MeSH-major] Hair Diseases / diagnosis. Hair Diseases / pathology. Pilomatrixoma / diagnosis. Pilomatrixoma / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology

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  • (PMID = 17718128.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Mahy P, Reychler H: [The pathology of salivary glands. Tumors of the salivary glands]. Rev Belge Med Dent (1984); 2006;61(3):141-53
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  • [Title] [The pathology of salivary glands. Tumors of the salivary glands].
  • [Transliterated title] Pathologie des glandes salivaires. Lésions tumorales des glandes salivaires.
  • The management of benign and malignant neoplasms of the salivary glands requires precise knowledge of tumor histogenesis and classification as well as surgical skills.
  • Pleomorphic adenoma and Whartin's tumor are the most frequent tumors in parotid glands while the probability for malignant tumors is higher in other glands, especially in sublingual and minor salivary glands.
  • Those malignant salivary glands tumors are rare and necessitate multidisciplinar staging and management in close collaboration with the pathologist and the radiation oncologist.
  • [MeSH-major] Salivary Gland Neoplasms / surgery
  • [MeSH-minor] Adenolymphoma / pathology. Adenoma, Pleomorphic / pathology. Humans. Neoplasm Staging. Prognosis. Radiotherapy, Adjuvant. Salivary Glands, Minor / pathology. Sublingual Gland Neoplasms / pathology

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  • (PMID = 17408135.001).
  • [ISSN] 0775-0293
  • [Journal-full-title] Revue belge de médecine dentaire
  • [ISO-abbreviation] Rev Belge Med Dent (1984)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Belgium
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6. Maffini F, Fasani R, Petrella D, Maiorano E, Bruschini R, Pelosi G, Viale G: Sebaceous lymphadenoma of salivary gland: a case report and a review of the literature. Acta Otorhinolaryngol Ital; 2007 Jun;27(3):147-50
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  • [Title] Sebaceous lymphadenoma of salivary gland: a case report and a review of the literature.
  • The unusual case is described of a benign parotid gland neoplasm with intermingled sebaceous and lymphoid tissue, synchronous to breast cancer.
  • In the past, the patient had undergone a simple surgical procedure for a cystic parotid gland lesion in that same gland.
  • Secondary neoplasms have only occasionally been reported, since there are few cases for corroborating the strong correlation between salivary neoplasms and other carcinomas as in Muir-Torre syndrome; the previous cystic lesion showed the origin of the neoplasm from a sebaceous inclusion in the lymph node as a postulate of Warthin tumour.
  • [MeSH-major] Adenolymphoma / pathology. Salivary Gland Neoplasms / pathology. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Neoplasm Invasiveness / pathology

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  • (PMID = 17883194.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 31
  • [Other-IDs] NLM/ PMC2640041
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7. Gierek T, Majzel K, Witkowska M, Jura-Szołtys E: [Analysis of 216 cases of pleomorphic adenoma of the parotid gland]. Otolaryngol Pol; 2005;59(3):329-32
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  • [Title] [Analysis of 216 cases of pleomorphic adenoma of the parotid gland].
  • Pleomorphic adenoma is the most frequent benign tumour of the salivary glands.
  • The most common localization is the parotid gland.
  • The frequency of incidence of mixed tumours is 50.70% of all 426 cases of parotid gland's tumours.
  • In 92, 13% cases the tumours was localized in the superficial part, only in 7.87% in deep part of the gland.
  • We don't noticed the incidence of salivary fistula in our material.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Incidence. Male. Middle Aged. Neoplasm Recurrence, Local. Poland / epidemiology

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  • (PMID = 16117385.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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8. Balakrishnan K, Castling B, McMahon J, Imrie J, Feeley KM, Parker AJ, Bull PD, Johnston A: Fine needle aspiration cytology in the management of a parotid mass: a two centre retrospective study. Surgeon; 2005 Apr;3(2):67-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The definitive histopathological diagnosis was compared with any pre-operative FNAC diagnosis.
  • RESULTS: For the University Teaching Hospital the sensitivity in distinguishing malignant from benign disease was 79% (95% CI 61-97%) with a specificity 84% (95% CI 73-95%).
  • However, three of eight patients with a primary parotid salivary gland malignancy were reported as having benign disease on FNAC.
  • For the participating District General Hospital the sensitivity in distinguishing malignant from benign disease was 38% (95% CI 13-63%) and specificity 95% (95% CI 73-95%).
  • CONCLUSIONS: Fine needle aspiration cytology does not reliably distinguish a benign from a malignant primary salivary gland neoplasm in the participating institutions.
  • [MeSH-minor] Diagnosis, Differential. Humans. Reproducibility of Results. Retrospective Studies. Sensitivity and Specificity

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  • [CommentIn] Surgeon. 2006 Jun;4(3):185-6; author reply 186 [16764208.001]
  • [CommentIn] Surgeon. 2006 Jun;4(3):185; author reply 186 [16764206.001]
  • [CommentIn] Surgeon. 2006 Jun;4(3):185; author reply 186 [16764207.001]
  • (PMID = 15861939.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Scotland
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9. Marques YM, de Lima Mde D, de Melo Alves Sde M Jr, Soares FA, de Araújo VC, Pinto Ddos S Jr, Mantesso A: Mdm2, p53, p21 and pAKT protein pathways in benign neoplasms of the salivary gland. Oral Oncol; 2008 Sep;44(9):903-8
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  • [Title] Mdm2, p53, p21 and pAKT protein pathways in benign neoplasms of the salivary gland.
  • The pAkt protein is closely related to Mdm2, and has not been previously reported in salivary gland tumors.
  • In conclusion, the signaling pathway in benign salivary gland neoplasm showed an important participation of Mdm2 overexpression protein in tumor formation, progression through inactivation of p53 action, or both, and of pAkt overexpression through increased translocation of Mdm2 protein to cellular nuclei.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Proto-Oncogene Proteins c-akt / metabolism. Proto-Oncogene Proteins c-mdm2 / metabolism. Salivary Gland Neoplasms / metabolism. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Cell Line, Tumor. Genes, p53 / genetics. Humans. Immunohistochemistry. Mutation. Signal Transduction / genetics

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  • (PMID = 18485798.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CDKN1A protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Tumor Suppressor Protein p53; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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10. Suwała P, Wilczyński K, Barnaś S, Prudlak E: [A rare case of multiple primary benign neoplasm of parotid gland: oncocytoma and adenolimphoma]. Otolaryngol Pol; 2009 Sep;63(7):89-92
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  • [Title] [A rare case of multiple primary benign neoplasm of parotid gland: oncocytoma and adenolimphoma].
  • AIM OF THE WORK: The authors present unusually rare case primary multiple synchronicus benign tumor of the ipsilateral parotid gland: oncocytoma and Warthin's tumor, which is rare among occasionally occurred multiple tumors with different histology in the salivary glands.
  • MATERIAL AND METHOD: A 71-year-old man presented with the tumor in the right parotid gland.
  • We performed excision of the superficial lobe of the parotid gland.
  • The preoperative ultrasonography and macroscopic analysis of the removed parotid gland tissue revealed only one tumor recognised histopathologically as adenolimphoma, but upon histopathological examination Warthin's tumor proved to coexist with oncocytoma.
  • RESULTS AND CONCLUSIONS: In the ultrasonography examination some salivary glands tumors may not be recognised.
  • The histopathological examination is the ultimate method in recognising tumors, which are not detected in the preoperative diagnosis.
  • The superficial parotidectomy protects from the recrudescence of the superficial lobe of the parotid gland tumors.
  • The coexistence of the oncocytoma and Warthin's in one parotid gland is extremely rare.
  • [MeSH-minor] Aged. Humans. Male. Parotid Gland / pathology. Rare Diseases. Treatment Outcome

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  • (PMID = 20564910.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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11. Lü BJ, Zhu J, Gao L, Xie L, Xu JY, Lai MD: [Diagnostic accuracy and pitfalls in fine needle aspiration cytology of salivary glands: a study of 113 cases]. Zhonghua Bing Li Xue Za Zhi; 2005 Nov;34(11):706-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnostic accuracy and pitfalls in fine needle aspiration cytology of salivary glands: a study of 113 cases].
  • OBJECTIVE: To describe the fine needle aspiration cytology (FNAC) features of various salivary gland lesions and to analyze the respective diagnostic value and pitfalls.
  • METHODS: 113 FNAC specimens of salivary gland lesions were reviewed and correlated with clinical and histopathologic findings.
  • RESULTS: The FNAC diagnostic failure (2); non-neoplastic lesions (12); benign neoplasm (82) and malignant neoplasm (17).
  • The three inaccurately diagnosed cases of FNAC are, as follows: reactive lymphoid hyperplasia of lymph node mistaken as non-Hodgkin lymphoma, mucoepidermoid carcinoma diagnosed as "scanty atypical cells present" and primary lymphoepithelial carcinoma mistaken as benign lymphoepithelial lesion.
  • On the basis of FNAC, 97.4% (110 /113) were correctly depicted as benign (95/96; 99.0%) or malignant (15/17; 88.2%).
  • Furthermore, 90.3% (102 /113) (specificity = 91.9%; 102/111) were accurately diagnosed, including 91.7% (88/96) benign lesions (specificity = 92.6% ; 88/95) and 82.4% (14/17) malignant tumors (specificity = 87.5%; 14/16).
  • CONCLUSIONS: FNAC is reliable in distinguishing benign and malignant salivary gland lesions.
  • A specific cytologic diagnosis is often possible.
  • On the other hand, due to the pitfalls in cytologic diagnosis of certain salivary gland tumors, tissue biopsy for histologic examination may be necessary.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Carcinoma, Squamous Cell / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology
  • [MeSH-minor] Adenolymphoma / pathology. Adenoma / pathology. Adenoma, Pleomorphic / pathology. Adolescent. Adult. Aged. Biopsy, Fine-Needle. Carcinoma, Adenoid Cystic / pathology. Child. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Male. Middle Aged. Parotid Neoplasms / pathology. Retrospective Studies. Submandibular Gland Neoplasms / pathology

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  • (PMID = 16536312.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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12. Gaissert HA, Mark EJ: Tracheobronchial gland tumors. Cancer Control; 2006 Oct;13(4):286-94
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  • [Title] Tracheobronchial gland tumors.
  • Bronchial gland tumors demonstrate oncologic diversity and include benign, low-grade, and high-grade malignant tumors.
  • METHODS: We reviewed the present knowledge of bronchial gland tumors of the trachea, carina, and bronchi, including the epidemiology, presentation, evaluation, tumor types, and treatment options.
  • RESULTS: The malignant bronchial gland tumors, adenoid cystic carcinoma and mucoepidermoid carcinoma, are far more common than benign mucinous cystadenoma or pleomorphic adenoma.
  • Complete resection of localized tumors has excellent long-term results in symptomatic benign tumors.
  • CONCLUSIONS: Expanding knowledge of diagnostic evaluation and surgical therapy can improve the long-term survival of patients with tracheobronchial gland tumors.
  • [MeSH-minor] Clinical Trials as Topic. Humans. Neoplasm Staging. Salivary Gland Neoplasms / pathology. Salivary Gland Neoplasms / therapy. Thoracic Surgical Procedures. United States / epidemiology

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  • (PMID = 17075566.001).
  • [ISSN] 1073-2748
  • [Journal-full-title] Cancer control : journal of the Moffitt Cancer Center
  • [ISO-abbreviation] Cancer Control
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 49
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13. Angiero F, Sozzi D, Seramondi R, Valente MG: Epithelial-myoepithelial carcinoma of the minor salivary glands: immunohistochemical and morphological features. Anticancer Res; 2009 Nov;29(11):4703-9
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  • [Title] Epithelial-myoepithelial carcinoma of the minor salivary glands: immunohistochemical and morphological features.
  • AIMS: Epithelial-myoepithelial carcinoma (EMC) is a rare malignant salivary gland neoplasm that most commonly occurs in the parotid gland, but can also arise in the minor salivary glands.
  • Three cases are reported of epithelial-myoepithelial carcinoma of the minor salivary glands, with the goal of better defining this entity.
  • All parts of each tumor were surrounded by a myoepithelial cell rim and there was evidence of invasion.
  • RESULTS: Immunohistochemical analysis showed the tumor cells to be weakly positive for S100, cytokeratin (CK) CK5/6, CK7, CKAE-1/AE-3 and strongly positive for epithelial membrane antigen (EMA) and p63; they were focally positive for calponin and acute lymphoblastic leukemia antigen (CD10).
  • The tumor cells were negative for vimentin, alpha-smooth muscle actin (SMA) (except one case), glial fibrillar acid protein (GFAP) and MIB1.
  • CONCLUSION: Three cases of minor salivary gland tumors are described and the differential diagnosis underlined in relation to benign myoepithelioma.
  • The characteristic morphological and immunohistochemical features aided diagnosis of these biphasic tumors.
  • [MeSH-major] Myoepithelioma / pathology. Salivary Gland Neoplasms / pathology


14. Andrade ES, Filho JR, Rocha NS, Neto IC, Camargo IB: Isolated intra-oral granular cell tumor: report of two cases and review of the literature. Acta Odontol Latinoam; 2010;23(2):99-104
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  • [Title] Isolated intra-oral granular cell tumor: report of two cases and review of the literature.
  • Granular cell tumor (GCT) is a relatively uncommon lesion occurring in almost any part of the body, including the orofacial region.
  • Although aggressive and malignant variants of this neoplasm have been described, most GCTs are benign.
  • The tumor generally occurs in middle-aged or older adults.
  • As most granular cell tumors are benign, surgical excision of the lesion is the treatment of choice.
  • Differential diagnoses include fibrous hyperplasia, minor salivary gland tumor condyloma acuminatum and neurilemmoma.
  • The main clinical pathology and diagnostic features of this neoplasm are reviewed and discussed.
  • [MeSH-major] Granular Cell Tumor / pathology. Tongue Neoplasms / pathology

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  • (PMID = 21053681.001).
  • [ISSN] 0326-4815
  • [Journal-full-title] Acta odontológica latinoamericana : AOL
  • [ISO-abbreviation] Acta Odontol Latinoam
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Argentina
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15. Panikar N, Agarwal S: Salivary gland manifestations of sinus histiocytosis with massive lymphadenopathy: fine-needle aspiration cytology findings. A case report. Diagn Cytopathol; 2005 Sep;33(3):187-90
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  • [Title] Salivary gland manifestations of sinus histiocytosis with massive lymphadenopathy: fine-needle aspiration cytology findings. A case report.
  • Seldom SHML may involve the salivary glands.
  • We present the cytologic features and differential diagnoses of one such case.A 45-yr-old woman presented with an enlarged submandibular gland on the left side with ipsilateral cervical lymphadenopathy that had been persisting for 1 mo.
  • The gland and the two enlarged nodes measured 2.5 x 2.5 cm(2) each and were firm in consistency.
  • Clinically, tumor of the salivary glands was suspected.
  • Isolated stromal fragments consisting of fibrocytes were seen separate from salivary acinar clusters on repeat aspirations.
  • The diagnosis of SHML involving left submandibular gland and ipsilateral lymph nodes was returned.
  • When analyzed in the context of clinical findings (laboratory data), the cytologic features of SHML involving salivary gland could be differentiated from those of malignancies and other benign lesions, especially Kuttner's tumor of the submandibular gland, which mimics neoplasm clinically.
  • [MeSH-major] Histiocytosis, Sinus / pathology. Salivary Gland Diseases / etiology. Salivary Gland Diseases / pathology
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Middle Aged

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  • [Copyright] Copyright (c) 2005 Wiley-Liss, Inc.
  • (PMID = 16078253.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Ganly I, Gross ND, Patel SG, Bilsky MH, Shah JP, Kraus DH: Outcome of craniofacial resection in patients 70 years of age and older. Head Neck; 2007 Feb;29(2):89-94
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  • Thirty-five patients had a malignant tumor and 1 patient a benign tumor; 15 (42%) had high-grade, 17 (47%) intermediate-grade, and 4 (11%) low-grade pathology.
  • [MeSH-major] Nose Neoplasms / surgery. Postoperative Complications. Salivary Gland Neoplasms / surgery. Skull Base Neoplasms / surgery
  • [MeSH-minor] Age Factors. Aged. Aged, 80 and over. Carcinoma / mortality. Carcinoma / pathology. Carcinoma / surgery. Cranial Fossa, Anterior / surgery. Cranial Fossa, Middle / surgery. Databases as Topic. Esthesioneuroblastoma, Olfactory / mortality. Esthesioneuroblastoma, Olfactory / pathology. Esthesioneuroblastoma, Olfactory / surgery. Female. Follow-Up Studies. Humans. Male. Melanoma / mortality. Melanoma / pathology. Melanoma / surgery. Neoplasm Recurrence, Local. Prospective Studies. Surgical Flaps. Survival Analysis


17. Kara MI, Göze F, Ezirganli S, Polat S, Muderris S, Elagoz S: Neoplasms of the salivary glands in a Turkish adult population. Med Oral Patol Oral Cir Bucal; 2010 Nov;15(6):e880-5
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  • [Title] Neoplasms of the salivary glands in a Turkish adult population.
  • OBJECTIVE: This retrospective study aimed to investigate the types and distribution of neoplasm of salivary glands in a Turkish population.
  • STUDY DESIGN: The histological diagnosis records of the Department of Pathology at Cumhuriyet University were reevaluated for 125 patients who were treated for salivary gland tumors from 1987 to 2008.
  • The neoplasms were analyzed for histological diagnosis, age, sex, and site.
  • RESULTS: A total of 125 primary salivary gland neoplasms, consisting of 95 (76%) benign and 30 (24%) malignant groups were recorded.
  • The most common major and minor salivary gland sites were the parotid (61.6%) and palatal glands (9.6%), respectively.
  • Pleomorphic adenoma was the most frequent benign tumor followed by Warthin's tumor.
  • CONCLUSIONS: Although there were some discrepancies, the characteristics of salivary gland tumors of Turkish patients are in line with those of patients from other countries according to tumor type, tumor site distribution, and age and sex of patients.
  • [MeSH-major] Salivary Gland Neoplasms / pathology

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  • (PMID = 20526249.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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18. Freedman LS, Oberman B, Sadetzki S: Using time-dependent covariate analysis to elucidate the relation of smoking history to Warthin's tumor risk. Am J Epidemiol; 2009 Nov 1;170(9):1178-85
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  • [Title] Using time-dependent covariate analysis to elucidate the relation of smoking history to Warthin's tumor risk.
  • The authors aimed to elucidate the relation of the time-dependent smoking history parameters--age at smoking initiation and smoking intensity, duration, and latency--to the risk of Warthin's tumor, a benign tumor of the salivary gland for which cigarette smoking is a strong risk factor.
  • They studied 117 cases of Warthin's tumor and 336 matched controls included in an Israeli nationwide case-control study of parotid gland tumors conducted from 2002 to 2003 by using the Cox regression model with time-dependent covariates, with age as the time axis.
  • The relation of smoking variables to Warthin's tumor agrees with the patterns reported for lung cancer.
  • [MeSH-major] Adenolymphoma / etiology. Salivary Gland Neoplasms / etiology. Smoking / adverse effects

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  • (PMID = 19755633.001).
  • [ISSN] 1476-6256
  • [Journal-full-title] American journal of epidemiology
  • [ISO-abbreviation] Am. J. Epidemiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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19. Gallego L, Junquera L, Fresno MF: Non-sebaceous lymphadenoma of the parotid gland: immunohistochemical study and DNA ploidy analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Apr;107(4):555-8
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  • [Title] Non-sebaceous lymphadenoma of the parotid gland: immunohistochemical study and DNA ploidy analysis.
  • Nonsebaceous lymphadenoma (NSL) is an unusual benign salivary gland tumor characterized by a predominant lymphoid background, dense lymphoid infiltrate, and absence of sebaceous differentiation.
  • We report an additional case of NSL arising in the parotid gland in 58-year-old female patient.
  • The extensive immunohistochemical investigation of the tumor revealed the presence of both luminal and myoepithelial cells.
  • The tumor was considered as being DNA diploid.

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  • (PMID = 19201224.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 68238-35-7 / Keratins
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20. Paul R, Shekar K, Singh M: Kuttner tumour: an unusual cause of enlargement of a minor salivary gland in the lip. Br J Oral Maxillofac Surg; 2010 Mar;48(2):152-3
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  • [Title] Kuttner tumour: an unusual cause of enlargement of a minor salivary gland in the lip.
  • Kuttner tumour is benign, chronic, sclerosing sialadenitis that usually occurs in the submandibular gland and is regarded as a salivary gland neoplasm because of its clinical features.
  • We describe a tumour arising from a minor salivary gland of the upper lip.
  • [MeSH-major] Lip Neoplasms / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology
  • [MeSH-minor] Chronic Disease. Diagnosis, Differential. Female. Humans. Middle Aged. Sialadenitis / diagnosis. Sialadenitis / etiology

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  • (PMID = 19926183.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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21. Manucha V, Ioffe OB: Metastasizing pleomorphic adenoma of the salivary gland. Arch Pathol Lab Med; 2008 Sep;132(9):1445-7
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  • [Title] Metastasizing pleomorphic adenoma of the salivary gland.
  • Metastasizing pleomorphic adenoma of salivary glands is a group of rare tumors that are histologically identical to benign mixed tumors and that inexplicably metastasize.
  • A review of the literature revealed that it usually occurs after multiple local recurrences, and the interval between diagnosis of primary pleomorphic adenoma and metastases ranges between 3 and 52 years.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Neoplasm Invasiveness / pathology. Salivary Gland Neoplasms / pathology. Salivary Gland Neoplasms / secondary
  • [MeSH-minor] Humans. Neoplasm Recurrence, Local / pathology

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  • (PMID = 18788859.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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22. Liess BD, Lane RV, Frazier S, Zitsch RP 3rd: Bilateral canalicular adenoma of the parotid gland. Arch Otolaryngol Head Neck Surg; 2006 Mar;132(3):339-41
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  • [Title] Bilateral canalicular adenoma of the parotid gland.
  • Canalicular adenoma is a rare benign salivary gland tumor that occurs almost exclusively in the upper lip.
  • Rarely, this benign tumor may occur multifocally in the oral cavity.
  • We report a case of canalicular adenoma in bilateral parotid glands, discuss histological characteristics, and review this tumor.

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  • (PMID = 16549756.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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23. Zhou CX, Gao Y: Oncocytoma of the salivary glands: a clinicopathologic and immunohistochemical study. Oral Oncol; 2009 Dec;45(12):e232-8
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  • [Title] Oncocytoma of the salivary glands: a clinicopathologic and immunohistochemical study.
  • We present a clinicopathologic and immunohistochemical study of 21 Chinese patients with oncocytoma of salivary gland origin, a rare benign tumour composed exclusively of large epithelial cells with eosinophilic granular cytoplasm (oncocytes).
  • In summary, clinical diagnosis for an oncocytoma is challenging for its similar features to other benign tumours.
  • Histopathological diagnosis is reliable with histochemical and electron microscopic conformation of the oncocytes, but differential diagnosis is still challenging.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Child. China. Diagnosis, Differential. Female. Humans. Male. Microscopy, Electron. Middle Aged. Neoplasm Proteins / metabolism

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  • (PMID = 19796983.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Antinuclear; 0 / Antibodies, Monoclonal; 0 / MIB-1 antibody; 0 / Neoplasm Proteins
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24. Uğuz MZ, Onal K, Demiray U, Ekinci N: Tumoral mass presenting in the nasomalar region arising from the lateral nasal wall: pleomorphic adenoma. Eur Arch Otorhinolaryngol; 2007 Nov;264(11):1377-9
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  • Pleomorphic adenoma is the most common benign salivary gland tumor.
  • Although the major salivary glands are the most common sites of its origin, it can also occur in the minor salivary glands of the oral cavity and rarely in the neck, ear, nasal cavity and larynx.
  • We report a rare case of intranasal pleomorphic adenoma arising from lateral nasal wall and discuss the clinical presentation, diagnosis and treatment approaches with the review of the literature.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Nasal Cavity / pathology. Nasal Septum / pathology. Nose Neoplasms / pathology. Salivary Gland Neoplasms / pathology. Zygoma / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Neoplasm Invasiveness. Tomography, X-Ray Computed

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  • (PMID = 17549505.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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25. Nilsson M, Panagopoulos I, Mertens F, Mandahl N: Fusion of the HMGA2 and NFIB genes in lipoma. Virchows Arch; 2005 Nov;447(5):855-8
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  • In addition, subsets of other benign solid tumors show aberrations of 12q13-15.
  • Among pleomorphic adenomas of the salivary glands, where the preferred recombination partner with 12q13-15 is 9p22-24, an HMGA2/NFIB fusion gene has been reported.
  • It was identical to a transcript that was previously described in salivary gland adenoma and contained a stop codon shortly 3' of the fusion point.
  • [MeSH-minor] Adult. Chromosomes, Human, Pair 12. Chromosomes, Human, Pair 9. DNA, Neoplasm / analysis. Gene Rearrangement. Humans. Male. Reverse Transcriptase Polymerase Chain Reaction. Sequence Analysis, DNA

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  • (PMID = 16133369.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / HMGA2 Protein; 0 / NFI Transcription Factors; 0 / NFIB protein, human
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26. Sirohi D, Sharma R, Sinha R, Suresh Menon P: Salivary gland neoplasms: an analysis of 74 cases. J Maxillofac Oral Surg; 2009 Jun;8(2):164-6
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  • [Title] Salivary gland neoplasms: an analysis of 74 cases.
  • Between 2006 and 2009, 74 cases of salivary gland neoplasms were analyzed retrospectively, of which 44 (60%) were benign and 30 (40%) malignant.
  • 61 % percent of neoplasms were in the parotid gland, 22% in the minor salivary glands including sublingual salivary glands, and 17% in the submandibular glands.
  • The most common benign neoplasm was pleomorphic adenoma (64%), and the most common malignant neoplasm were adenoid cystic carcinoma (17%) and mucoepidermoid carcinoma (23%).
  • We analyze the incidence and distribution of all types of salivary gland neoplasms in our series, and provide data for comparison with other epidemiological studies from different geographical sites and races.
  • Further epidemiological surveys should be encouraged for better understanding of the disease and to provide early and better treatment of salivary gland neoplasms.

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  • (PMID = 23139498.001).
  • [ISSN] 0972-8279
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3453927
  • [Keywords] NOTNLM ; Parotid / Pleomorphic adenoma / Sublingual / Submandibular / mucoepidermoid carcinoma
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27. Noseri H, Erden T, Toros S, Habesoglu M, Egeli E, Aker F, Cetin S: Intraductal papilloma of the parotid gland in a child. Eur Arch Otorhinolaryngol; 2007 Nov;264(11):1385-6
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  • [Title] Intraductal papilloma of the parotid gland in a child.
  • Intraductal papillomas are rare benign tumors, most commonly encountered in minor salivary glands and rarely in major salivary glands.
  • They are cystic, solitary neoplasm that arise from ductal epithelium and produce painless swelling.
  • We report a case of intraductal papilloma of the parotid gland in a child.

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  • (PMID = 17598121.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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28. John BJ, Griffiths C, Ebbs SR: Pleomorphic adenoma of the breast should be excised with a cuff of normal tissue. Breast J; 2007 Jul-Aug;13(4):418-20
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  • Pleomorphic adenoma is a benign tumor found rarely in the breast but commonly in the salivary gland.
  • Unlike the salivary gland variant management guidelines are poorly defined in the breast.
  • Due to the risk of recurrence and malignant transformation, we recommend complete excision of the lesion with a cuff of normal tissue, as is the practice in the salivary gland.
  • Clinicians should be aware of the condition, as preoperative diagnosis will facilitate adequate surgery.
  • [MeSH-minor] Adult. Female. Humans. Neoplasm Recurrence, Local / surgery

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  • (PMID = 17593049.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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29. de Araújo VC, Altemani A, Furuse C, Martins MT, de Araújo NS: Immunoprofile of reactive salivary myoepithelial cells in intraductal areas of carcinoma ex-pleomorphic adenoma. Oral Oncol; 2006 Nov;42(10):1011-6
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  • [Title] Immunoprofile of reactive salivary myoepithelial cells in intraductal areas of carcinoma ex-pleomorphic adenoma.
  • The myoepithelial cell (MC) is a component of various secretory glands, including salivary glands.
  • Besides its function, a tumor suppressor and a tumor facilitating functions have been attributed to this cell.
  • We investigated the immunoprofile of benign MC in intraductal areas of carcinoma ex-pleomorphic adenoma (CXPA), comparing them with the MC in duct-like areas of pleomorphic adenoma, origin of the malignant tumor.
  • The immunohistochemical reactions of all the antibodies showed stronger staining in benign MC surrounding the malignant epithelial cells than in benign MC in duct-like areas of pleomorphic adenoma, thus revealing that in the malignization process the benign MC become differentiated and produce important proteins related to the tumor suppressor function.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma, Pleomorphic / metabolism. Biomarkers, Tumor / metabolism. Neoplasm Proteins / metabolism. Salivary Gland Neoplasms / metabolism

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  • (PMID = 16757205.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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30. Berardi D, Scoccia A, Perfetti G, Berardi S: Recurrence of pleomorphic adenoma of the palate after sixteen years: case report and an analysis of the literature. J Biol Regul Homeost Agents; 2009 Oct-Dec;23(4):225-9
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  • Pleomorphic adenoma or mixed tumour (MT) is a benign neoplasia of slow growth and epithelial histogenesis.
  • The case reported is of particular interest due to many aspects: the outbreak from the minor salivary glands; the male sex; the young age of the patient at the first sign of the tumour; the appearance of a recurrence after 16 years, not contemplated in literature; and finally, the rapid growth of the second appearance.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Neoplasm Recurrence, Local / surgery. Palatal Neoplasms / surgery. Salivary Gland Neoplasms / surgery
  • [MeSH-minor] Adult. Humans. Male. Palate, Hard / pathology. Palate, Hard / surgery. Salivary Glands, Minor. Time Factors

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  • (PMID = 20003761.001).
  • [ISSN] 0393-974X
  • [Journal-full-title] Journal of biological regulators and homeostatic agents
  • [ISO-abbreviation] J. Biol. Regul. Homeost. Agents
  • [Language] eng
  • [Publication-type] Case Reports; Editorial; Review
  • [Publication-country] Italy
  • [Number-of-references] 23
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31. Khandekar MM, Kavatkar AN, Patankar SA, Bagwan IB, Puranik SC, Deshmukh SD: FNAC of salivary gland lesions with histopathological correlation. Indian J Otolaryngol Head Neck Surg; 2006 Jul;58(3):246-8
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  • [Title] FNAC of salivary gland lesions with histopathological correlation.
  • HYPOTHESIS: Analysis of salivary gland lesions by FNAC and correlation with histopathology.
  • To evaluate utility of FNAC in salivary gland lesions.Back ground: Salivary gland lesions form about 2-6.5% of all head and neck neoplasms in adults.
  • They are easily accessible for FNAC (Fine Needle Aspiration Cytology) and risks of fistula formation or tumour implantation are low compared surgical biopsy.
  • Also, cytology can provide a distinction between asalivary and non salivary lesion, benign and malignant lesions so also specific and non specific inflammation.
  • RESULTS: 80% of the lesions were neoplastic (61% benign, 31% malignant) and 20% were neoplastic.
  • Pleomorphic adenoma was the most frequent benign neoplasm while mucoepidermoid carcinoma was the most frequent malignant lesion.
  • CONCLUSIONS: FNAC was found to be a useful diagnostic tool in the evaluation of salivary gland lesions because of its simplicity, excellent patient compliance and rapid diagnosis.

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  • (PMID = 23120304.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450424
  • [Keywords] NOTNLM ; FNAC / Salivary Gland / Salivary Gland Tumours
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32. Logasundaram R, Amarawickrama H, Premachandra D, Hellquist H: Intracapsular (in situ) carcinoma ex pleomorphic adenoma with unusual clinical and histological features. Eur Arch Otorhinolaryngol; 2008 Dec;265(12):1563-6
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  • Carcinoma ex pleomorphic adenoma poses a challenge to diagnosis and treatment.
  • Herein we describe an extremely unusual case, which presented initially as an intracapsular carcinoma ex pleomorphic adenoma in the right parotid gland.
  • The first recurrence, after an interval of 8 years, showed only recurrence of the benign component.
  • This case report elucidates the atypical clinical behaviour and interesting histological features encountered within this group of salivary neoplasm.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma in Situ / pathology. Myoepithelioma / pathology. Neoplasm Recurrence, Local / pathology. Parotid Neoplasms / pathology

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  • (PMID = 18288478.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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33. Minicucci EM, de Campos EB, Weber SA, Domingues MA, Ribeiro DA: Basal cell adenoma of the upper lip from minor salivary gland origin. Eur J Dent; 2008 Jul;2(3):213-6
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  • [Title] Basal cell adenoma of the upper lip from minor salivary gland origin.
  • Basal cell adenoma is an uncommon benign salivary gland neoplasm, presenting isomorphic basaloid cells with a prominent basal cell layer.
  • Taking into account that basal cell adenomas represent 1% of all salivary gland tumors, being the majority of cases in the parotid glands, the goal of this paper is to report a case of basal cell adenoma of the upper lip arising from minor salivary gland.

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  • (PMID = 19212550.001).
  • [ISSN] 1305-7456
  • [Journal-full-title] European journal of dentistry
  • [ISO-abbreviation] Eur J Dent
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Other-IDs] NLM/ PMC2635906
  • [Keywords] NOTNLM ; Basal cell adenoma / Immunohistochemistry / Minor salivary gland
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34. Shigeishi H, Mizuta K, Higashikawa K, Yoneda S, Ono S, Kamata N: Correlation of CENP-F gene expression with tumor-proliferating activity in human salivary gland tumors. Oral Oncol; 2005 Aug;41(7):716-22
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  • [Title] Correlation of CENP-F gene expression with tumor-proliferating activity in human salivary gland tumors.
  • We examined the expression of Centromere protein F (CENP-F) mRNA in 26 human salivary gland tumors (seven pleomorphic adenomas, three Warthin tumors, seven mucoepidermoid carcinomas, four adenoid cystic carcinomas, four acinic cell carcinomas and one malignant myoepithelioma) and four normal submandibular glands using the real time quantitative reverse transcription-polymerase chain reaction (RT-PCR).
  • The mean expression level of CENP-F mRNA was higher in malignant tumors (1.05+/-0.32) than normal submandibular glands (0.11+/-0.05) and benign tumors (0.46+/-0.16).
  • [MeSH-major] Adenoma / genetics. Chromosomal Proteins, Non-Histone / genetics. Gene Expression Regulation, Neoplastic / genetics. Salivary Gland Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Proliferation. Female. Humans. Male. Microfilament Proteins. Middle Aged. RNA, Messenger / metabolism. RNA, Neoplasm / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Submandibular Gland / metabolism

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  • Gene Ontology. gene/protein/disease-specific - Gene Ontology annotations from this paper .
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  • (PMID = 15927522.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / Microfilament Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / centromere protein F
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35. Harimaya A, Somekawa Y, Sasaki M, Ohuchi T: Cystadenocarcinoma (papillary cystadenocarcinoma) of the submandibular gland. J Laryngol Otol; 2006 Dec;120(12):1077-80
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  • [Title] Cystadenocarcinoma (papillary cystadenocarcinoma) of the submandibular gland.
  • Cystadenocarcinoma (papillary cystadenocarcinoma) of the salivary gland is a rare malignant neoplasm.
  • Major locations of this neoplasm are the parotid gland, the sublingual gland, and minor salivary glands, while occurrence in the submandibular gland is extremely rare.
  • As far as we know, only one report, written in the French language, has been published concerning cystadenocarcinoma of the submandibular gland, but no report is available in the English language.
  • In this report, we describe a case of cystadenocarcinoma arising from the submandibular gland of a 54-year-old male patient.
  • The neoplasm is a low-grade carcinoma, and pre-operative examination may not show typical characteristics of malignant neoplasms.
  • Therefore, as was true in this case, the differential diagnosis from benign lesions is sometimes difficult.
  • This is the first report on cystadenocarcinoma of the submandibular gland in the English language and the first to show a computed tomography (CT) scan and magnetic resonance imaging (MRI) of this neoplasm in the submandibular gland.
  • [MeSH-major] Cystadenocarcinoma, Papillary / pathology. Submandibular Gland Neoplasms / pathology

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  • (PMID = 16995970.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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36. Farah-Klibi F, Ferchiou M, Kourda J, El Amine O, Ferjaoui M, Ben Jilani S, Zermani R: [Parotid basal cell adenoma of membranous type]. Tunis Med; 2009 Feb;87(2):149-51
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  • [Transliterated title] Adenome a cellules basales de type membraneux de la parotide.
  • INTRODUCTION: Basal cell adenoma (BCA) is a rare benign neoplasm characterized by the basaloid appearance of the tumour cells and the lack of myxo-chondroid stromal component present in pleomorphic adenoma.
  • So the diagnosis of metastatic malignant salivary gland tumor was suspected.
  • CONCLUSION: The BCA is a benign tumor located generally in the parotid gland.
  • When the malignancy is suspected, like in our case, this tumor must be differentiated from the basal cell adenocarcinoma using histological criteria.
  • [MeSH-major] Adenoma / diagnosis. Parotid Neoplasms / diagnosis. Sarcoidosis / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Humans. Lymphatic Metastasis. Mediastinum / radiography. Treatment Outcome

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  • (PMID = 19522450.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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37. Perez DE, Lopes MA, de Almeida OP, Jorge J, Kowalski LP: Plasmacytoid myoepithelioma of the palate in a child. Int J Paediatr Dent; 2007 May;17(3):223-7
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  • BACKGROUND: Myoepithelioma is a rare benign salivary gland tumour, localized most frequently in the parotid and in minor intraoral salivary glands.
  • The diagnosis was consistent with myoepithelioma, plasmocytoid variant.
  • Tumour cells were positive for cytokeratins, vimentin and S-100 protein.
  • Surgical resection was performed and no evidences of tumour recurrence were observed after 6 years of the treatment.
  • CONCLUSION: Myoepithelioma is a very rare tumour in children and apparently presents a good prognosis, similar to occur in adult patients.

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  • (PMID = 17397468.001).
  • [ISSN] 0960-7439
  • [Journal-full-title] International journal of paediatric dentistry
  • [ISO-abbreviation] Int J Paediatr Dent
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins
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38. Pantelis A, Wenghoefer M, Haas S, Merkelbach-Bruse S, Pantelis D, Jepsen S, Bootz F, Winter J: Down regulation and nuclear localization of human beta-defensin-1 in pleomorphic adenomas of salivary glands. Oral Oncol; 2009 Jun;45(6):526-30
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  • [Title] Down regulation and nuclear localization of human beta-defensin-1 in pleomorphic adenomas of salivary glands.
  • Although antimicrobial peptides (AMPs) appear to have diverse functional activities in innate immunity, a few reports suggest a potential role of human beta-defensin (hBD)-1 in tumor suppression.
  • The aim of the present study was to compare the expression patterns of hBD-1, -2 and -3 in various features of human salivary gland tissues, such as healthy parenchyma, chronic sialadenitis and intraglandular pleomorphic adenomas, with their adjacent normal tissues.
  • Twenty human salivary gland specimens (five healthy, five chronic sialadenitis, five pleomorphic adenomas and five adenoma adjacent normal tissues (AANTs)) were investigated for mRNA expression levels of hBD-1, -2 and -3 by quantitative real-time RT-PCR.
  • Considerably increased, 80-fold higher hBD-1 and increased hBD-3 mRNA expression levels compared to healthy salivary gland tissues were detected in chronic sialadenitis.
  • Interestingly, the AANTs showed a 48-fold higher expression of hBD-1 and increased hBD-3 expression compared to the healthy salivary gland.
  • These data support the hypothesis that hBD-1 might be a potential tumor suppressor also in benign salivary gland tumors in addition to other genetic alterations.
  • [MeSH-major] Adenoma, Pleomorphic / metabolism. Neoplasm Proteins / metabolism. Salivary Gland Neoplasms / metabolism. beta-Defensins / metabolism

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  • (PMID = 18805729.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DEFB1 protein, human; 0 / DEFB4A protein, human; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / beta-Defensins; 0 / beta-defensin 3, human
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39. Weissferdt A, Langman G: An intracapsular carcinoma ex pleomorphic adenoma with lung metastases composed exclusively of benign elements: histological evidence of a continuum between metastasizing pleomorphic adenoma and carcinoma ex pleomorphic adenoma. Pathol Res Pract; 2010 Jul 15;206(7):480-3
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  • [Title] An intracapsular carcinoma ex pleomorphic adenoma with lung metastases composed exclusively of benign elements: histological evidence of a continuum between metastasizing pleomorphic adenoma and carcinoma ex pleomorphic adenoma.
  • Malignant mixed tumors of the salivary glands, encompassing carcinoma ex pleomorphic adenoma (ca ex PA), carcinosarcoma and metastasizing pleomorphic adenoma (mPA), are rare neoplasms.
  • When the malignant component does not breach the capsule of the parent PA, the lesion is termed intracapsular ca ex PA, a neoplasm which is thought to have no metastatic potential.
  • Metastatic deposits of ca ex PA are composed exclusively of malignant elements or mixed benign and malignant components.
  • The metastatic deposits resembled benign PA with no histological evidence of malignancy.
  • This pattern of spread is described with mPA, an entity that caused controversy in the past regarding its exact classification as a benign or malignant tumor.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Lung Neoplasms / secondary. Mouth Mucosa / pathology. Salivary Gland Neoplasms / pathology

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  • [Copyright] Copyright 2009 Elsevier GmbH. All rights reserved.
  • (PMID = 19665316.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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40. Spoto G, della Malva M, Rubini C, Fioroni M, Piattelli A, Serra E, Di Nicola M, Santoleri F: cAMP phosphodiesterase activity evaluation in human carcinoma of salivary glands. Nucleosides Nucleotides Nucleic Acids; 2006;25(9-11):1113-7
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  • [Title] cAMP phosphodiesterase activity evaluation in human carcinoma of salivary glands.
  • The aim of this study was to evaluate differences of cAMP-PDE activity in human salivary glands, between a control group and some different benign tumours groups and, where present, with 2 malignant tumors groups.
  • The differences between the control group (82 +/- 7.9 nmols/mg of protein) and the 3 pathologic groups (Benign A: 44 +/- 6.2; Malignant A: 40 +/- 16; Benign B: 40 +/- 14.2; Malign A: 9.1; Benign C: 22 nmols/mg of protein) are statistically significant.
  • [MeSH-major] 3',5'-Cyclic-AMP Phosphodiesterases / metabolism. Carcinoma / enzymology. Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Salivary Gland Neoplasms / enzymology. Salivary Glands / enzymology
  • [MeSH-minor] Case-Control Studies. Cyclic AMP / chemistry. Disease Progression. Humans. Neoplasm Metastasis. Nucleotides, Cyclic / chemistry

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  • (PMID = 17065074.001).
  • [ISSN] 1525-7770
  • [Journal-full-title] Nucleosides, nucleotides & nucleic acids
  • [ISO-abbreviation] Nucleosides Nucleotides Nucleic Acids
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nucleotides, Cyclic; E0399OZS9N / Cyclic AMP; EC 3.1.4.17 / 3',5'-Cyclic-AMP Phosphodiesterases
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41. Guzzo M, Ferrari A, Marcon I, Collini P, Gandola L, Pizzi N, Casanova M, Mattavelli F, Scaramellini G: Salivary gland neoplasms in children: the experience of the Istituto Nazionale Tumori of Milan. Pediatr Blood Cancer; 2006 Nov;47(6):806-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Salivary gland neoplasms in children: the experience of the Istituto Nazionale Tumori of Milan.
  • BACKGROUND: Epithelial salivary gland tumors are very uncommon in pediatric age.
  • These results are presented in conjunction with a literature review of salivary tumors with a view to providing an up-to-date overview of the clinical course, prognosis, and treatment options for this rare tumor.
  • PROCEDURE: Fifty-two cases of epithelial salivary tumors were reviewed and the clinical-pathological information concerning tumor characteristics, therapy, and follow-up were collected.
  • RESULTS: The major salivary glands were the main site of tumor occurrence (79% of cases arose in parotid glands); 37 patients had benign tumors (pleomorphic adenoma), 15 had malignant tumors (12 mucoepidermoid carcinoma, 9 low grade).
  • All the patients were treated by surgery; local relapses after parotidectomy were 4% and 25%, in benign and malignant tumors, respectively.
  • When tumor enucleation was performed, recurrences occurred in 50% of benign neoplasms.
  • At the time of the report, all patients with benign tumors were alive, 35(95%) without evidence of disease; only one patient with malignant tumor died of disease.
  • CONCLUSIONS: Epithelial salivary glands tumor in children had different characteristics compared with their adult counterpart with respect to the frequency of histotypes and site of occurrence, but their prognosis seems to be similar.
  • Parotidectomy (total or superficial) is the best choice for achieving good cure rates in both benign and malignant tumors.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Carcinoma, Acinar Cell / surgery. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Mucoepidermoid / surgery. Neoplasm Recurrence, Local / surgery. Salivary Gland Neoplasms / surgery

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16425245.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Behzatoglu K, Bahadir B, Huq GE, Kaplan HH: Spontaneous infarction of a pleomorphic adenoma in parotid gland: diagnostic problems and review. Diagn Cytopathol; 2005 Jun;32(6):367-9
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  • [Title] Spontaneous infarction of a pleomorphic adenoma in parotid gland: diagnostic problems and review.
  • Although infarction of parotid gland pleomorphic adenoma (PA) following fine-needle aspiration (FNA) has been well-documented, spontaneous infarction of PA has remained as an uncommon entity in the literature.
  • To our knowledge, we report the second case of spontaneous infarction occurring in a parotid gland PA.
  • Although appears to be rare, spontaneous infarction of PA should be considered in the differential diagnosis, since necrosis may mimic carcinoma and cause misinterpretation of necrosis as an indication of malignancy, in an otherwise benign salivary gland neoplasm.
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Humans. Male. Parotid Gland / blood supply. Parotid Gland / pathology

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  • (PMID = 15880698.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Alcure ML, Della Coletta R, Graner E, Di Hipolito O Jr, Lopes MA: Sialolithiasis of minor salivary glands: a clinical and histopathological study. Gen Dent; 2005 Jul-Aug;53(4):278-81
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  • [Title] Sialolithiasis of minor salivary glands: a clinical and histopathological study.
  • Sialolithiasis is one of the most common disorders of particular major salivary glands.
  • It is caused by sialolith within the ducts or parenchyma of particularly major salivary glands.
  • Although sialolithasis is not uncommon, it often is clinically misdiagnosed when minor salivary glands are affected.
  • This article describes the clinical and microscopic findings of nine cases of sialolithiasis of minor salivary glands.
  • The most common clinical hypotheses for diagnosis were mucocele, sialoadenitis, and benign salivary gland tumor.
  • Sialolithiasis of minor salivary glands was misdiagnosed frequently.
  • It should be considered as a possible diagnosis when swelling of the oral tissues is observed.
  • [MeSH-major] Salivary Gland Calculi / pathology. Salivary Glands, Minor / pathology
  • [MeSH-minor] Adult. Aged. Cheek. Diagnosis, Differential. Female. Humans. Lip. Male. Middle Aged. Mouth Mucosa

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  • (PMID = 16158797.001).
  • [ISSN] 0363-6771
  • [Journal-full-title] General dentistry
  • [ISO-abbreviation] Gen Dent
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. Azevedo Rde S, Pires FR, Della Coletta R, de Almeida OP, Kowalski LP, Lopes MA: Oral myofibromas: report of two cases and review of clinical and histopathologic differential diagnosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Jun;105(6):e35-40
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  • [Title] Oral myofibromas: report of two cases and review of clinical and histopathologic differential diagnosis.
  • Myofibroma is a benign mesenchymal neoplasm composed of myofibroblasts which has been described with different synonyms since the first report in 1951.
  • Differential diagnosis included benign and malignant mesenchymal neoplasms, salivary gland tumors, and reactive processes.
  • Microscopic analysis of both lesions revealed a spindle cell tumor with immunoreactivity for vimentin, muscle-specific actin, and specific smooth muscle isoform alpha-actin, rendering the diagnoses of myofibroma.
  • Myofibroma presents a wide range of differential diagnosis, including benign and malignant neoplasms.
  • Therefore, accurate diagnosis may avoid an unnecessary aggressive therapy.
  • [MeSH-minor] Actins / analysis. Child. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Vimentin / analysis

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  • (PMID = 18417385.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Vimentin
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45. Lin C, Li J, Lu N: [Analysis of 2161 cases of neoplasm in oral maxillofacial region in Xinjiang]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2010 Sep;45(9):553-5
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  • [Title] [Analysis of 2161 cases of neoplasm in oral maxillofacial region in Xinjiang].
  • OBJECTIVE: To investigate the incidence and constituent characteristic of neoplasm in oromaxillo-facial region in Xinjiang.
  • METHODS: A total of 2161 patients with benign or malignant oral-maxillofacial tumors diagnosed in Department of Dentofacial Surgery of the First Affiliated Hospital of Xinjiang Medical College from 1995 to 2009 were analyzed retrospectively.
  • RESULTS: Of the 2161 cases, 58.49% (1264/2161) was benign tumors, 33.13% (716/2161) malignant tumors, and 8.38% (181/2161) tumor-like lesions.
  • The most common benign tumors were pleomorphic adenoma, hemangioma, papilloma, adenolymphoma and ameloblastoma.
  • The most common malignant tumors of salivary gland were adenoid cystic carcinoma.
  • The most common sites of malignant tumors were tongue, lip, parotiod gland and buccal mucosa.
  • CONCLUSIONS: The common pathological type of oral and maxillofacial benign neoplasm and the most common sites of malignancy in Xinjiang region were similar to those of other places inside and outside the country.
  • Adenoid cystic carcinoma was more common than other salivary originated tumors.
  • [MeSH-minor] Adenolymphoma. Adenoma, Pleomorphic. Ameloblastoma. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. China / epidemiology. Face. Humans. Incidence. Mouth Mucosa. Odontogenic Tumors. Retrospective Studies. Salivary Gland Neoplasms

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  • (PMID = 21122451.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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46. Singh S, Shivamurthy DM, Agarwal R: Pleomorphic adenoma of the soft palate. J Maxillofac Oral Surg; 2010 Mar;9(1):76-7
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  • Pleomorphic adenoma is the commonest benign salivary gland tumour, accounting for almost three fourths of all such tumours.
  • Pleomorphic adenoma most commonly occurs in the parotid gland; however it is also encountered in the submandibular, sublingual and minor salivary glands.Almost half of all salivary gland tumours are malignant, pleomorphic adenoma is the commonest benign lesion.A case of pleomorphic adenoma arising denovo in the minor salivary glands is discussed.

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  • [Cites] Oral Surg Oral Med Oral Pathol. 1988 Sep;66(3):323-33 [2845326.001]
  • [Cites] Int J Oral Maxillofac Surg. 1986 Dec;15(6):777-9 [3027209.001]
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  • (PMID = 23139574.001).
  • [ISSN] 0972-8279
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3453680
  • [Keywords] NOTNLM ; Minor salivary gland tumours / Pleomorphic adenoma
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47. Dewan K, Owens J, Silvester K: Maintaining a high level of suspicion for recurrent malignant disease: report of a case with periapical involvement. Int Endod J; 2007 Nov;40(11):900-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIM: To report the unusual endodontic presentation and radiographic features of a subgroup of pleomorphic adenoma called carcinoma ex pleomorphic adenoma and to stress the importance of maintaining a high level of suspicion in cases where primary or recurrent neoplasia is included in the differential diagnosis.
  • SUMMARY: This paper describes a case in which a patient with a previous history of malignant neoplasm presented with signs and symptoms similar to a dental infection.
  • The pathology report however confirmed recurrence of the previous tumour in a malignant fashion.
  • KEY LEARNING POINTS: *Pleomorphic adenomas, also known as benign mixed tumours, are common salivary gland tumours, which infrequently undergo malignant transformation, with potentially devastating consequences.
  • *Malignant salivary gland tumours can present as dental swelling, dental pain and sudden loss of vitality of teeth so both general practitioners and specialists have the responsibility to evaluate such patients with a broad vision.
  • *Radiographic differential diagnosis of periapical radiolucency should also include malignant salivary gland tumours.
  • *This case highlights the need of vigilance at all times and emphasizes the benefits of biopsy and histological examination in the diagnosis of recurrent malignant salivary gland tumours.
  • [MeSH-major] Adenocarcinoma / radiography. Adenoma, Pleomorphic / radiography. Maxillary Neoplasms / radiography. Neoplasm Recurrence, Local / radiography. Periapical Diseases / radiography. Salivary Gland Neoplasms / radiography
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male

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  • (PMID = 17764459.001).
  • [ISSN] 0143-2885
  • [Journal-full-title] International endodontic journal
  • [ISO-abbreviation] Int Endod J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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48. Ghosh A, Arundhati, Asthana AK: Pleomorphic adenoma of the parotid gland metastasizing to the scapular region: a case report. Acta Cytol; 2008 Nov-Dec;52(6):733-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pleomorphic adenoma of the parotid gland metastasizing to the scapular region: a case report.
  • BACKGROUND: Metastasizing pleomorphic adenoma (MPA) is a rare, incompletely understood enigmatic entity having the histologic appearance of benign pleomorphic adenoma and clinically malignant behavior.
  • We report a case of MPA of the parotid gland that metastasized to the scapular region 6 years after the appearance of the primary lesion in the left parotid gland.
  • The patient had a prior history of surgical removal of recurrent pleomorphic adenoma of the left parotid salivary gland.
  • Fine needle aspiration cytology (FNAC) smears of both sites demonstrated the 3 components (i.e., stromal, mesenchymal and epithelial) of benign pleomorphic adenoma with benign features.
  • The diagnosis was MPA.
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Female. Humans. Neoplasm Metastasis

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  • (PMID = 19068682.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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49. Pacchioni D, Volante M, Casetta G, Sapino A, Marchiò C, Bussolati G: Myxoid renal tumor with myoepithelial differentiation mimicking a salivary gland pleomorphic adenoma: description of a case. Am J Surg Pathol; 2007 Apr;31(4):632-6
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  • [Title] Myxoid renal tumor with myoepithelial differentiation mimicking a salivary gland pleomorphic adenoma: description of a case.
  • We herein report an unusual case of a low-grade myxoid renal epithelial neoplasm, with peculiar and previously unreported morphologic and immunohistochemical features.
  • The lesion morphologically resembled a pleomorphic adenoma of the salivary gland.
  • The tumor proved benign at follow-up.
  • A definitive classification and histogenetic interpretation of this previously unreported tumor type awaits description of further cases showing similar features which, perhaps, as it may happen, went so far unnoticed.
  • [MeSH-minor] Adenoma, Pleomorphic / pathology. Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Salivary Gland Neoplasms / pathology

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  • (PMID = 17414112.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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50. Westernoff TH, Jordan RC, Regezi JA, Ramos DM, Schmidt BL: Beta-6 Integrin, tenascin-C, and MMP-1 expression in salivary gland neoplasms. Oral Oncol; 2005 Feb;41(2):170-4
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  • [Title] Beta-6 Integrin, tenascin-C, and MMP-1 expression in salivary gland neoplasms.
  • The objective of this study was to determine whether there is overexpression of these molecules in three types of salivary neoplasms showing markedly different behavior.
  • Staining was graded as 0 (<1% positive tumor cells), 1+ (<25% positive tumor cells), 2+ (25-50% positive tumor cells), and 3+ (>50% positive cells).
  • The results showed that the malignant tumors were higher expressors of beta-6 than the benign tumors.
  • No significant difference was observed between ACCs and PLGAs. beta-6 expression was rarely seen in normal salivary gland epithelium and was occasionally present in mucosa overlying the tumors.
  • A majority of tumors in all three tumor types showed high expression of MMP1 with expression significantly greater in the PAs compared to ACCs (p=0.008).
  • We conclude that ACCs and PLGAs express beta-6, tenascin-C, and MMP-1, but that their expression patterns are not significantly different. beta-6 appears to be more closely associated with the malignant tumors, and MMP-1 more closely associated with the benign tumors.
  • We believe that beta-6, tenascin-C, and MMP-1 proteins are part of the molecular repertoire used by salivary tumors for malignant invasion and benign tumor expansion.
  • [MeSH-major] Integrin beta Chains / metabolism. Matrix Metalloproteinase 1 / metabolism. Neoplasm Proteins / metabolism. Salivary Gland Neoplasms / metabolism. Tenascin / metabolism

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  • (PMID = 15695119.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Grant] United States / PHS HHS / / 11RT-0141; United States / PHS HHS / / 12KT-0166; United States / NCI NIH HHS / CA / CA095231; United States / NIDCR NIH HHS / DE / DE14609; United States / NIDCR NIH HHS / DE / K23DE00443; United States / NIDCR NIH HHS / DE / P01DE13904; United States / NIDCR NIH HHS / DE / R0I DE12856; United States / NIDCR NIH HHS / DE / R0I DEO11930
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Integrin beta Chains; 0 / Neoplasm Proteins; 0 / Tenascin; 0 / integrin beta6; EC 3.4.24.7 / Matrix Metalloproteinase 1
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51. Schache AG, Hall G, Woolgar JA, Nikolaidis G, Triantafyllou A, Lowe D, Risk JM, Shaw RJ, Liloglou T: Quantitative promoter methylation differentiates carcinoma ex pleomorphic adenoma from pleomorphic salivary adenoma. Br J Cancer; 2010 Dec 7;103(12):1846-51
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  • [Title] Quantitative promoter methylation differentiates carcinoma ex pleomorphic adenoma from pleomorphic salivary adenoma.
  • BACKGROUND: potential epigenetic biomarkers for malignant transformation to carcinoma ex pleomorphic adenoma (Ca ex PSA) have been sought previously with and without specific comparison with the benign variant, pleomorphic salivary adenoma (PSA).
  • We sought to demonstrate quantitative promoter methylation across a panel of tumour suppressor genes (TSGs) in both Ca ex PSA and PSA.
  • METHODS: quantitative methylation-specific real-time polymerase chain reaction (qMSP) analysis of p16(INK4A), CYGB, RASSF1, RARβ, human telomerase reverse transcriptase (hTERT), Wilms' tumour 1 (WT1) and TMEFF2 gene promoters was undertaken on bisulphite-converted DNA, previously extracted from archival fixed tissue specimens of 31 Ca ex PSA and an unrelated cohort of 28 PSA.
  • All target regions examined had formerly been shown to be hypermethylated in salivary and/or mucosal head and neck malignancies.
  • CONCLUSIONS: we demonstrate the successful application of qMSP to a large series of historical Ca ex PSA samples and report on a panel of TSGs with significant differences in their methylation profiles between benign and malignant variants of pleomorphic salivary adenoma. qMSP analysis could be developed as a useful clinical tool to differentiate between Ca ex PSA and its benign precursor.
  • [MeSH-major] Adenoma, Pleomorphic / genetics. DNA Methylation. Promoter Regions, Genetic. Salivary Gland Neoplasms / genetics
  • [MeSH-minor] Genes, Tumor Suppressor. Humans. Membrane Proteins / genetics. Neoplasm Proteins / genetics. Polymerase Chain Reaction. Telomerase / genetics. WT1 Proteins / genetics

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  • [Copyright] 2010 Cancer Resaerch UK.
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  • (PMID = 21063414.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / TMEFF2 protein, human; 0 / WT1 Proteins; EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
  • [Other-IDs] NLM/ PMC3008600
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52. Chakrabarti S, Bera M, Bhattacharya PK, Chakrabarty D, Manna AK, Pathak S, Maiti K: Study of salivary gland lesions with fine needle aspiration cytology and histopothology along with immunohistochemistry. J Indian Med Assoc; 2010 Dec;108(12):833-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Study of salivary gland lesions with fine needle aspiration cytology and histopothology along with immunohistochemistry.
  • Salivary gland swelling is a common and important problem.
  • Acute and chronic sialadenitis, different benign and malignant neoplasms are the common causes which present with salivary gland swelling.
  • Imaging technique is not so helpful in pre-operative diagnosis; microscopical examination is required for diagnosis.
  • Pre-operative core needle biopsy is hazardous and may damage facial nerve, lead to fistula formation or associated with tumour seeding.
  • The study was done with 40 cases of salivary gland swelling.
  • Out of 40 cases, 25 involved the parotid gland, most common age group affected was 20 - 40 years and male: female ratio was 5: 3.
  • Among these 3 cases, 2 were adenoid cystic carcinoma which was cytologically diagnosed as benign neoplasm (monomorphic adenoma).
  • One case of Warthin's tumour was cytologically diagnosed as pleomorphic adenoma.
  • This study corroborates well with other studies including immunohistochemical findings. p53 expression was found to be related with nature of the neoplasm.
  • FNAC is an important tool for early diagnosis of salivary gland lesions.
  • [MeSH-major] Biopsy, Fine-Needle. Salivary Gland Diseases / pathology

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  • (PMID = 21661459.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] India
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53. Ozawa H, Tomita T, Sakamoto K, Tagawa T, Fujii R, Kanzaki S, Ogawa K, Kameyama K, Fujii M: Mucoepidermoid carcinoma of the head and neck: clinical analysis of 43 patients. Jpn J Clin Oncol; 2008 Jun;38(6):414-8
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  • While the high-grade type is a highly aggressive tumor, its low-grade counterpart usually demonstrates a more benign nature and several systems have, therefore, been proposed to grade this neoplasm.
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Analysis of Variance. Disease-Free Survival. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Predictive Value of Tests. Prognosis. Proportional Hazards Models. Radiotherapy, Adjuvant. Retrospective Studies. Salivary Gland Neoplasms / therapy. Sex Factors. Treatment Outcome

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  • (PMID = 18573852.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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54. Kazakov DV, Zelger B, Rütten A, Vazmitel M, Spagnolo DV, Kacerovska D, Vanecek T, Grossmann P, Sima R, Grayson W, Calonje E, Koren J, Mukensnabl P, Danis D, Michal M: Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on the study of 24 cases, sporadic or occurring in the setting of Brooke-Spiegler syndrome. Am J Surg Pathol; 2009 May;33(5):705-19
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  • The authors present a series of 24 malignant neoplasms arising in preexisting benign spiradenoma (20), cylindroma (2), and spiradenocylindroma (2).
  • Nineteen patients (12 females, 7 males; age range, 41 to 92 y) had a solitary neoplasm (size range, 2.2 to 17.5 cm; median 4 cm), whereas the remaining 5 (4 females, 1 male; age range, 66 to 72 y) manifested clinical features of Brooke-Spiegler syndrome (BSS), an autosomal dominantly inherited disease characterized by widespread, small, benign neoplasms on which background larger malignant lesions appeared.
  • Microscopically, all cases showed the residuum of a preexisting benign neoplasm.
  • 1) salivary gland type basal cell adenocarcinoma-like pattern, low-grade (BCAC-LG);.
  • 2) salivary gland type basal cell adenocarcinoma-like pattern, high-grade (BCAC-HG);.
  • 3) invasive adenocarcinoma, not otherwise specified (IAC-NOS); and 4) sarcomatoid (metaplastic) carcinoma.
  • In 1 case of IAC-NOS, an in situ adenocarcinoma was also found, presumed to have evolved from an adjacent adenomatous and atypical adenomatous component.
  • Cases harboring a sarcomatoid carcinoma featured a malignant epithelial component composed of varying combinations of BCAC-HG, BCAC-LG, IAC-NOS, or squamous cell carcinoma, whereas the sarcomatoid component appeared as either a pleomorphic or spindle-cell sarcoma.
  • The histologic pattern of the malignant neoplasm correlated to some extent with the clinical course.
  • Given the morphologic diversity and complexity of the neoplasms in question, we propose using a more specific terminology with the precise description of the neoplasm components, rather than generic and less informative terms such as "spiradenocarcinoma" or "carcinoma ex cylindroma. "
  • [MeSH-major] Adenoma / pathology. Carcinoma / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Salivary Gland Neoplasms / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Australia. Carcinoma, Skin Appendage / pathology. Carcinoma, Squamous Cell / pathology. Cell Differentiation. Chromosomes, Human, Pair 16. Europe. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Male. Metaplasia. Middle Aged. Mutation. Neoplasm Invasiveness. South Africa. Syndrome. Treatment Outcome. Tumor Suppressor Proteins / genetics


55. Otoh EC, Johnson NW, Olasoji H, Danfillo IS, Adeleke OA: Salivary gland neoplasms in Maiduguri, north-eastern Nigeria. Oral Dis; 2005 Nov;11(6):386-91
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  • [Title] Salivary gland neoplasms in Maiduguri, north-eastern Nigeria.
  • OBJECTIVE: To document the pattern of salivary gland neoplasia in Maiduguri, Nigeria.
  • MATERIALS AND METHODS: Information on demographics, diagnosis and cancer management in the hospital were retrieved from biopsy reports and case notes of patients.
  • RESULTS: The palatal (71.9%) and parotid (78.3%) glands were the most common minor and major salivary glands involved, with a benign-malignant ratio of 1:1 and 1.4:1, respectively.
  • Pleomorphic adenoma (44.3%) was the most common salivary gland neoplasm recorded.
  • Mucoepidermoid carcinoma (10.1%) was the most common salivary gland malignancy, occurring in the second and sixth decades; of equal gender distribution and predominantly in the palate (50%).
  • CONCLUSION: Pleomorphic adenoma and mucoepidermoid carcinoma were the most commonly reported benign and malignant neoplasia in this series.
  • [MeSH-major] Carcinoma, Squamous Cell / epidemiology. Palatal Neoplasms / epidemiology. Salivary Gland Neoplasms / epidemiology

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  • (PMID = 16269031.001).
  • [ISSN] 1354-523X
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Denmark
  • [Number-of-references] 30
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56. Shaw CK, Sood S, Bradley PJ, Krishnan S: Unusual mass in the parapharyngeal space: a Warthin's tumour. ANZ J Surg; 2006 Mar;76(3):193-4
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  • [Title] Unusual mass in the parapharyngeal space: a Warthin's tumour.
  • Most of the PPS tumours are salivary tumours (pleomorphic adenoma being the most frequent diagnosis), and are thought to originate from minor salivary glands or the deep lobe of the parotid gland.
  • Warthin's tumour, another benign salivary tumour involving the PPS has been rarely reported.
  • A case of bilateral, metachronous Warthin's tumour involving the PPS is reported here.
  • PPS Warthin's tumour is a very rare condition that if undiagnosed may result in considerable morbidity.
  • [MeSH-minor] Aged. Female. Humans. Neoplasm Invasiveness. Parotid Gland / surgery. Tomography, X-Ray Computed

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  • (PMID = 16626365.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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57. Ota T, Ota K, Jono H, Fujimori H, Ueda M, Shinriki S, Sueyoshi T, Shinohara M, Ando Y: Midkine expression in malignant salivary gland tumors and its role in tumor angiogenesis. Oral Oncol; 2010 Sep;46(9):657-61
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  • [Title] Midkine expression in malignant salivary gland tumors and its role in tumor angiogenesis.
  • The aims of this study were to investigate midkine (MK) expression patterns in salivary gland tumors (SGTs) and to evaluate the correlation between MK expression and the degree of malignancy.
  • Immunohistochemistry showed that MK protein expression was significantly higher in specimens of malignant SGTs (ACC [P<0.01] and MEC [P<0.001]) than in benign SGT (PA) samples.
  • These results suggest that MK may play important roles in malignant transformation and tumor angiogenesis in SGTs.
  • [MeSH-major] Carcinoma, Mucoepidermoid / metabolism. Cytokines / physiology. Neoplasm Proteins / physiology. Neovascularization, Pathologic / pathology. Salivary Gland Neoplasms / metabolism

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20637680.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cytokines; 0 / Neoplasm Proteins; 137497-38-2 / midkine
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58. Nouraei SA, Ferguson MS, Clarke PM, Sandison A, Sandhu GS, Michaels L, Rhys-Evans P: Metastasizing pleomorphic salivary adenoma. Arch Otolaryngol Head Neck Surg; 2006 Jul;132(7):788-93
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  • [Title] Metastasizing pleomorphic salivary adenoma.
  • OBJECTIVE: To address questions about the etiology, behavior, optimal treatment, and prognosis of metastasizing pleomorphic adenoma (MPA), we undertook a review of the literature (1953-2005) and constructed a virtual series of all identified cases of MPA, metastatic lesions that are very occasionally identified in patients with a history of pleomorphic salivary adenoma and, on detailed pathological evaluation, found to exhibit all the histological hallmarks of the preceding benign lesions.
  • There was an overwhelming history of incomplete surgery for pleomorphic salivary adenoma.
  • Developing distant lesions within 10 years of the primary tumor and presence of metastases in multiple sites were independent predictors of survival on Cox regression analysis.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Proportional Hazards Models. Survival Analysis. Treatment Outcome

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  • (PMID = 16847191.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] United States
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59. Steele NP, Wenig BM, Sessions RB: A case of pleomorphic adenoma of the parotid gland metastasizing to a mediastinal lymph node. Am J Otolaryngol; 2007 Mar-Apr;28(2):130-3
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  • [Title] A case of pleomorphic adenoma of the parotid gland metastasizing to a mediastinal lymph node.
  • OBJECTIVE: Pleomorphic adenomas are the most common salivary gland tumors and are typically cured with complete surgical excision.
  • There are rare reports, however, in which these histologically benign tumors have inexplicably metastasized to distant sites.
  • The patient's presentation, workup, and final diagnosis of benign metastasizing pleomorphic adenoma will be discussed, along with a pertinent review of the literature.
  • RESULTS: A diagnosis of recurrent pleomorphic adenoma was made from a fine needle aspiration biopsy of the right parotid mass.
  • Examination of the pathology specimens confirmed a diagnosis of pleomorphic adenoma in both the parotid bed and the mediastinum.
  • No histologic characteristics of malignancy were seen in either specimen; therefore, a diagnosis of benign metastasizing mixed tumor was rendered.
  • CONCLUSION: Benign metastasizing pleomorphic adenoma is a rare and controversial but distinct clinical entity.
  • Although the definition of the term benign precludes metastatic disease, these tumors do not demonstrate any malignant features yet metastasize to distant sites.
  • It remains to be determined whether these benign metastasizing pleomorphic adenomas are really low-grade salivary malignancies.
  • [MeSH-minor] Adult. Female. Humans. Lymphatic Metastasis. Mediastinum / pathology. Neoplasm Recurrence, Local / pathology

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  • (PMID = 17362821.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. Matsubayashi S, Yoshihara T: Carcinoma ex pleomorphic adenoma of the salivary gland: an immunohistochemical study. Eur Arch Otorhinolaryngol; 2007 Jul;264(7):789-95
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  • [Title] Carcinoma ex pleomorphic adenoma of the salivary gland: an immunohistochemical study.
  • The proliferative activity of the tumor cells and the expression of tumor-associated genes and sex steroid hormone receptors were investigated immunohistochemically in ten cases of carcinoma ex pleomorphic adenoma (Ca-ex-PA) of the salivary glands.
  • These were analyzed in benign and malignant components separately, and then were compared with ten cases of the other malignant tumors [adenocarcinomas, not otherwise specified (ACN) and salivary duct carcinomas (SDC)] and ten cases of pleomorphic adenomas (PA).
  • (1) malignant component of Ca-ex-PA showed a higher incidence of PCNA and Ki67 than benign component of Ca-ex-PA.
  • A significant difference between benign component of Ca-ex-PA and PA was not observed. (2) A significant difference in the incidence of p53, c-erbB-2, EGFR overexpression was observed only between malignant component of Ca-ex-PA and benign component of Ca-ex-PA. (3) The incidence of PCNA, Ki67, p53, c-erbB-2 overexpression in malignant component of Ca-ex-PA showed the highest data among the four groups.
  • These results suggest that Ca-ex-PA acquired the particular biological behavior in contrast to the other salivary neoplasms in the long-standing process while PA undergoes malignant transformation.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Antibodies, Neoplasm / immunology. Biomarkers, Tumor / immunology. Carcinoma, Ductal / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry / methods. Ki-67 Antigen / immunology. Ki-67 Antigen / metabolism. Male. Middle Aged. Neoplasm Recurrence, Local / immunology. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Proliferating Cell Nuclear Antigen / immunology. Proliferating Cell Nuclear Antigen / metabolism. Receptor, Epidermal Growth Factor / immunology. Receptor, Epidermal Growth Factor / metabolism. Receptor, ErbB-2 / immunology. Receptor, ErbB-2 / metabolism. Receptors, Androgen / immunology. Receptors, Androgen / metabolism. Receptors, Estrogen / immunology. Receptors, Estrogen / metabolism. Retrospective Studies. Tumor Suppressor Protein p53 / immunology. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 17310348.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen; 0 / Receptors, Androgen; 0 / Receptors, Estrogen; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
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61. Roh JL, Park CI: Gland-preserving surgery for pleomorphic adenoma in the submandibular gland. Br J Surg; 2008 Oct;95(10):1252-6
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  • [Title] Gland-preserving surgery for pleomorphic adenoma in the submandibular gland.
  • BACKGROUND: Removal of tumours arising in the submandibular gland (SMG) usually involves excision of the entire gland.
  • This prospective study evaluated the efficacy of gland-preserving surgery in patients with benign SMG tumours.
  • METHODS: Twenty consecutive patients with pleomorphic adenomas in the SMG underwent local excision of tumours with limited tumour-free margins and preservation of the remnant glandular tissues.
  • All patients had salivary scintigraphy before and 6 months after surgery, with ultrasonography 2 years after operation.
  • Complications, operating time, salivary function and rates of tumour recurrence were evaluated.
  • After surgery, the function of the affected gland was equal to that of the unaffected gland.
  • None of the patients had evidence of tumour recurrence on ultrasonographic examination and regular clinical examination at a median of 36 months after surgery.
  • CONCLUSION: Gland-preserving surgery in patients with benign SMG tumours preserves salivation, and reduces surgical morbidity and operating time, with good cosmesis but without compromising local control.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Submandibular Gland / surgery. Submandibular Gland Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Length of Stay. Male. Middle Aged. Neoplasm Recurrence, Local. Prospective Studies. Saliva / secretion

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  • (PMID = 18720459.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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62. Rajan KV, Santhi T: A case of solitary fibrous tumour of the nose and paranasal sinuses. Indian J Otolaryngol Head Neck Surg; 2006 Jul;58(3):316-8
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  • [Title] A case of solitary fibrous tumour of the nose and paranasal sinuses.
  • Solitary fibrous tumours (SFT), formerly known as benign fibrous mesothelioma, are rare mesenchymal spindle cell neoplasms, originally described in the pleura, but now found to arise in many other locations such as mediastinum, urogenital tract, face, nose, paranasal sinuses, orbit, meninges, ear, buccal mucosa, tongue, salivary gland etc.
  • It was first described as a distinct neoplasm in 1931 by Klemperer and Rabin.
  • A case of solitary fibrous tumour of the nose and paranasal sinuses is presented.

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  • (PMID = 23120332.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450392
  • [Keywords] NOTNLM ; Solitary fibrous tumour / paranasal sinuses
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63. Maruya S, Shirasaki T, Nagaki T, Kakehata S, Kurotaki H, Mizukami H, Shinkawa H: Differential expression of topoisomerase IIalpha protein in salivary gland carcinomas: histogenetic and prognostic implications. BMC Cancer; 2009;9:72
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  • [Title] Differential expression of topoisomerase IIalpha protein in salivary gland carcinomas: histogenetic and prognostic implications.
  • BACKGROUND: Salivary gland carcinomas are relatively uncommon heterogeneous malignancies characterized by locoregional invasion and distant metastasis.
  • The purpose of this study was to evaluate the expression of topoIIalpha in various types of salivary gland tumors and its biological significance.
  • METHODS: The protein expression of topoIIalpha was evaluated immunohistochemically in formalin-fixed, paraffin-embedded tissue from 54 salivary gland carcinomas and 20 benign tumors (10 pleomorphic adenomas and 10 Warthin's tumors).
  • The primary salivary gland carcinoma specimens consisted of 17 adenoid cystic carcinomas, 7 adenocarcinomas not otherwise specified, 7 mucoepidermoid carcinomas, 6 salivary duct carcinomas, 3 acinic cell carcinomas, 3 carcinomas ex pleomorphic adenomas, 3 epithelial-myoepithelial carcinomas, 2 carcinosarcomas, 2 lymphoepithelial carcinomas, 2 myoepithelial carcinomas, 1 oncocytic carcinoma, and 1 squamous cell carcinoma.
  • RESULTS: Of the 54 primary salivary gland carcinomas, 38 (70%) showed positive expression (> or = 10%) of topoIIalpha protein, and 16 carcinomas (30%) and all benign tumors were negative (p < 0.001).
  • Expression of topoIIalpha was more frequently observed in salivary duct carcinoma, carcinoma ex pleomorphic adenoma, adenocarcinoma, and adenoid cystic carcinoma, solid type, and it was associated with advanced stage and shortened survival.
  • Furthermore, it may provide useful prognostic information and suggests the potential efficacy of topoIIalpha-targeting therapy in patients with salivary gland carcinoma.
  • [MeSH-major] Antigens, Neoplasm / biosynthesis. DNA Topoisomerases, Type II / biosynthesis. DNA-Binding Proteins / biosynthesis. Salivary Gland Neoplasms / enzymology

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  • (PMID = 19250538.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / DNA-Binding Proteins; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
  • [Other-IDs] NLM/ PMC2654461
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64. Hayashi D, Tysome JR, Boyei E, Gluckman P, Barbaccia C: Sebaceous lymphadenoma of the parotid gland: report of two cases and review of the literature. Acta Otorhinolaryngol Ital; 2007 Jun;27(3):144-6
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  • [Title] Sebaceous lymphadenoma of the parotid gland: report of two cases and review of the literature.
  • Sebaceous lymphadenoma is an unusual salivary gland neoplasm which is rarely correctly diagnosed pre-operatively in the parotid gland.
  • Two cases of sebaceous lymphadenoma are presented in which, in common with most cases reported in the literature, the correct pre-operative diagnosis was not made.
  • Sebaceous lymphadenoma rarely transforms into a malignant tumour.
  • Fine needle aspiration cytology identifies a benign process in the majority of patients who receive appropriate treatment on this basis.
  • Although an uncommon tumour, it should be taken into consideration in the differential diagnosis of a solitary parotid mass.
  • [MeSH-major] Adenolymphoma / surgery. Parotid Neoplasms / surgery. Sebaceous Gland Neoplasms / surgery
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 17883193.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 20
  • [Other-IDs] NLM/ PMC2640048
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65. Nakaya K, Oshima T, Watanabe M, Hidaka H, Kikuchi T, Higashi K, Honkura Y, Hara Y, Kobayashi T: A case of myoepithelioma of the nasal cavity. Auris Nasus Larynx; 2010 Oct;37(5):640-3
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  • Myoepithelioma is a rare tumor, most frequently located in the salivary gland.
  • Case reports of extra-salivary myoepithelioma are sporadic, with only one case in the nasal cavity.
  • Histological examination revealed myoepithelial cells and myxoid stroma, which confirmed the diagnosis of myoepithelioma.
  • The behavioral pattern is similar to if not identical with that of the mixed tumor, pleomorphic adenoma, which is benign, but the potential for recurrence is always present, especially if complete resection is not achieved.
  • [MeSH-major] Myoepithelioma / diagnosis. Nasal Cavity. Nose Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Biopsy. Humans. Magnetic Resonance Imaging. Male. Maxillary Sinus / pathology. Neoplasm Invasiveness. Tomography, X-Ray Computed

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  • [Copyright] Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20392578.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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66. Vranic S, Caughron SK, Djuricic S, Bilalovic N, Zaman S, Suljevic I, Lydiatt WM, Emanuel J, Gatalica Z: Hamartomas, teratomas and teratocarcinosarcomas of the head and neck: Report of 3 new cases with clinico-pathologic correlation, cytogenetic analysis, and review of the literature. BMC Ear Nose Throat Disord; 2008;8:8
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  • METHODS: We describe here two new cases of multilineage tumors including sinonasal teratocarcinosarcoma [SNTCS], and congenital oronasopharyngeal teratoma (epignathus) and compare their features with those of a new case of a rare salivary gland anlage tumor [SGAT], an entity for which the pathogenesis is unclear (i.e. hamartoma versus neoplasm).
  • Both cytogenetic abnormalities are characteristically present in malignant germ cell tumors providing for the first time evidence that this rare tumor type indeed might represent a variant of a germ cell neoplasm.
  • The SGAT and epignathus carried no such cytogenetic abnormalities, in keeping with their limited and benign biologic potential.
  • Malignant tumors of germ cell origins are more likely to affect adults with insidious symptom development, while benign tumors can nevertheless cause dramatic clinical symptoms which, under certain circumstances, can be fatal.

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  • (PMID = 19025657.001).
  • [ISSN] 1472-6815
  • [Journal-full-title] BMC ear, nose, and throat disorders
  • [ISO-abbreviation] BMC Ear Nose Throat Disord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2611960
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67. de Moraes M, de Matos FR, de Carvalho CP, de Medeiros AM, de Souza LB: Sialolipoma in minor salivary gland: case report and review of the literature. Head Neck Pathol; 2010 Sep;4(3):249-52
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  • [Title] Sialolipoma in minor salivary gland: case report and review of the literature.
  • Sialolipoma is a rare benign neoplasm characterized by a well-circumscribed mass composed of neoplastic mature adipose tissue and non-neoplastic salivary gland elements.
  • Microscopically, the tumor was well-circumscribed consisting of lobular proliferation of the lipomatous tissue with thin fibrous tissue septa containing clustered salivary gland elements.
  • The definitive diagnosis was sialolipoma.
  • Of these 35 cases, 16 cases were located in minor salivary glands.
  • The age distribution was from 27 to 84 years (mean, 61.6 years) and the tumor size ranged from 0.9 to 4 cm (mean, 1.7 cm).
  • [MeSH-major] Lipoma / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Salivary Glands, Minor / pathology. Salivary Glands, Minor / surgery. Treatment Outcome

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  • (PMID = 20563675.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2923305
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68. Wierzbicka M, Kopeć T, Szyfter W, Bem G: [Epidemiology of non-malignant salivary gland tumours based on 675 cases]. Otolaryngol Pol; 2010 Sep-Oct;64(5):281-7
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  • [Title] [Epidemiology of non-malignant salivary gland tumours based on 675 cases].
  • Neoplasm of salivary glands constitutes about 3% of all tumours of head and neck.
  • What lies behind such great differences in the changes within the salivary glands is complex embryogenesis of the glands.
  • About 80% of all tumours of salivary glands is located in parotid gland, from 10 to 20% - in submandibular gland and several percent in sublingual and small salivary gland.
  • This work aims at the assessment of the frequency of occurrence of non-malignant neoplasm in parotid and submandibular gland based on the material collected at the ENT Department of the Medical University in Poznan in the years 1995-2006.
  • In the 12-year period, 778 patients in total suffered from tumours of large salivary glands.
  • The number of non-malignant neoplasm was 675, and the number of malignant neoplasm was 103.
  • Main aim of this work has been achieved through the execution of partial steps: the analysis of the trends in occurrence of non-malignant neoplasm in the 12-year period, the analysis of the epidemiological differences: sex, age, place of residence - town or country, duration of symptoms, diameter of the tumour at the time the patient reported for treatment, histological structures that were carried on the basis of the comparison of data collected in the two periods of time: period I--the years 1995-2000 and period II--the years 2001-2006.
  • The frequency of operations on non-malignant tumours of salivary glands (as compared to the total number of operations) was 4.11% in the first period and 4.18% in the second.
  • In both periods the most frequent benign tumour was the mixed tumour (54.9% of all tumours) and constituted 60% and 54% of all tumours in the respective periods analyzed.
  • The next most frequently occurring tumour was Warthin's tumour, identified in 31.2% of the patients, in 23% in period I and 35% in period II.
  • Duration of the symptoms, ranged from 1 month to 20 years, 14 months on average, yet in 263 cases the tumour has been developing developed for over a year.
  • [MeSH-major] Rural Population / statistics & numerical data. Salivary Gland Diseases / epidemiology. Salivary Gland Diseases / pathology. Urban Population / statistics & numerical data
  • [MeSH-minor] Adult. Age Distribution. Age Factors. Aged. Female. Humans. Incidence. Male. Middle Aged. Neoplasm Staging. Poland / epidemiology. Prognosis. Salivary Gland Neoplasms / epidemiology. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology. Young Adult

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  • (PMID = 21166137.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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69. Cohen SM, Burkey BB, Netterville JL: Surgical management of parapharyngeal space masses. Head Neck; 2005 Aug;27(8):669-75
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  • Age, sex, diagnosis, surgical approach, complications, and outcome were collected.
  • RESULTS: One hundred sixty-six PPS masses were identified: 21 (12.7%) were malignant, 145 (87.3%) were benign, 76 (45.8%) were vascular, and 69 (41.6 %) involved the skull base.
  • Expected neurologic sequelae resulted from cranial nerve involvement by tumor.
  • CONCLUSION: Careful patient assessment and surgical techniques allow the oncologically safe removal of benign, vascular, and skull base PPS tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Infant. Lymph Node Excision. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasms, Vascular Tissue / diagnosis. Neoplasms, Vascular Tissue / pathology. Neoplasms, Vascular Tissue / surgery. Paraganglioma / diagnosis. Paraganglioma / pathology. Paraganglioma / surgery. Retrospective Studies. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / pathology. Salivary Gland Neoplasms / surgery. Skull Base Neoplasms / diagnosis. Skull Base Neoplasms / pathology. Skull Base Neoplasms / surgery. Treatment Outcome

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  • [Copyright] Copyright 2005 Wiley Periodicals, Inc.
  • (PMID = 15880689.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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70. Barrese JL, Lau S, Chen BT, Maghami E: Nonparotid parapharyngeal oncocytoma: a case report and literature review. Head Neck; 2010 Jun;32(6):800-5
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  • Oncocytoma is a rare, benign salivary neoplasm composed of mitochondria-rich cells called oncocytes.
  • Although oncocytoma usually occurs in the parotid glands, it has much less commonly been reported to occur in minor salivary gland tissues.
  • Excision of the mass, through a transcervical approach, demonstrated it to be an isolated oncocytoma of the parapharyngeal space, noncontiguous with the parotid gland.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Pharyngeal Neoplasms / diagnosis

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  • [Copyright] (c) 2009 Wiley Periodicals, Inc. Head Neck, 2010.
  • (PMID = 19787785.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 37
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71. Al-Rawi NH, Omer H, Al Kawas S: Immunohistochemical analysis of P(53) and bcl-2 in benign and malignant salivary glands tumors. J Oral Pathol Med; 2010 Jan;39(1):48-55
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  • [Title] Immunohistochemical analysis of P(53) and bcl-2 in benign and malignant salivary glands tumors.
  • BACKGROUND: Salivary glands tumors are relatively uncommon neoplasm with widely variable histopathologic and biologic characteristics.
  • Alteration in some proto-oncogenes and tumor suppressor genes may lead to the development and progression of these tumors.
  • AIMS: The purpose of this study was to analyze the immunohistochemical expression of P(53) and bcl-2 in some salivary gland tumors in relation to tumor size, histologic grade, and extent of invasion.
  • SETTING AND DESIGN: The sample consisted of 22 formalin-fixed paraffin embedded blocks of benign and malignant salivary glands tumors.
  • MATERIAL AND METHOD: P(53) and bcl-2 immunoreactivity was semi-quantitatively evaluated in at least 1000 cells examined under the microscope at 40x magnification and recorded as percentage of P(53) or bcl-2 positive tumor cells over the total number of cells examined in the same area.
  • RESULTS AND CONCLUSION: Pleomorphic adenoma (PA) showed negative expression of P(53) and bcl-2 in 70% of cases, whereas all malignant salivary glands tumors were positive for P(53) and bcl-2.
  • P(53)/bcl-2 immunostaining reactivity could be helpful in demonstrating salivary glands tumor behavior in terms of progression and extent of invasion.
  • [MeSH-major] Proto-Oncogene Proteins c-bcl-2 / analysis. Salivary Gland Neoplasms / pathology. Tumor Suppressor Protein p53 / analysis
  • [MeSH-minor] Adenocarcinoma / pathology. Adenoma, Pleomorphic / pathology. Adolescent. Adult. Aged. Carcinoma / pathology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / pathology. Cell Count. Female. Humans. Immunohistochemistry. Lymph Nodes / pathology. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Invasiveness. Neoplasms, Multiple Primary / pathology

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  • (PMID = 19761475.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53
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72. He H, Chen G, Zhou L, Liu Y: A joint detection of CEA and CA-50 levels in saliva and serum of patients with tumors in oral region and salivary gland. J Cancer Res Clin Oncol; 2009 Oct;135(10):1315-21
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  • [Title] A joint detection of CEA and CA-50 levels in saliva and serum of patients with tumors in oral region and salivary gland.
  • OBJECTIVE: To detect the levels of carcinoembryonic antigen (CEA) and carcinoma associated antigen CA-50 in the patients with oral or salivary malignant tumors.
  • METHODS: The concentrations of salivary CEA and CA-50 were assayed in 80 patients of oral and salivary malignant tumors, 40 patients of benign tumors and 80 health controls.
  • RESULTS: Salivary CEA and CA-50 levels were significantly higher in malignant tumors than in benign tumors and in health controls, respectively (P < 0.001).
  • This may be more useful as prognostic indicators in early diagnosis of oral and salivary malignant tumors.
  • [MeSH-major] Adenoma / blood. Antigens, Tumor-Associated, Carbohydrate / analysis. Carcinoembryonic Antigen / analysis. Mouth Neoplasms / blood. Saliva / chemistry. Salivary Gland Neoplasms / blood
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Case-Control Studies. Enzyme-Linked Immunosorbent Assay. Female. Humans. Immunoradiometric Assay. Male. Middle Aged. Neoplasm Staging. Prognosis. Survival Rate. Young Adult

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  • [Cites] J Surg Oncol. 2001 Dec;78(4):253-8 [11745820.001]
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  • (PMID = 19322585.001).
  • [ISSN] 1432-1335
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, Tumor-Associated, Carbohydrate; 0 / CA-50 antigen; 0 / Carcinoembryonic Antigen
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73. Takahama Junior A, Almeida OP, Kowalski LP: Parotid neoplasms: analysis of 600 patients attended at a single institution. Braz J Otorhinolaryngol; 2009 Jul-Aug;75(4):497-501
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  • Salivary gland tumors are rare, generally benign and affect mainly the parotid gland.
  • RESULTS: 600 cases of parotid tumors were selected; 369 were benign and 231 were malignant.
  • Pleomorphic adenoma was the most frequent benign tumor.
  • The most common malignant tumor was the mucoepidermoid carcinoma.
  • Benign tumors were mostly the pleomorphic adenoma, which were more frequent than malignancies.
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Retrospective Studies. Treatment Outcome

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  • (PMID = 19784416.001).
  • [ISSN] 1808-8686
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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74. Apple SK, Moatamed NA, Lai CK, Bhuta S: Sebaceous adenoma of the parotid gland: a case report with fine needle aspiration findings and histologic correlation. Acta Cytol; 2009 Jul-Aug;53(4):419-22
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  • [Title] Sebaceous adenoma of the parotid gland: a case report with fine needle aspiration findings and histologic correlation.
  • BACKGROUND: Sebaceous adenoma of the salivary gland is an extremely rare, benign neoplasm that predominantly involves the major salivary glands.
  • CONCLUSION: We report a case ofa rare and unusual tumor of the salivary glands.

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  • (PMID = 19697727.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Maruyama S, Cheng J, Shingaki S, Tamura T, Asakawa S, Minoshima S, Shimizu Y, Shimizu N, Saku T: Establishment and characterization of pleomorphic adenoma cell systems: an in-vitro demonstration of carcinomas arising secondarily from adenomas in the salivary gland. BMC Cancer; 2009;9:247
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  • [Title] Establishment and characterization of pleomorphic adenoma cell systems: an in-vitro demonstration of carcinomas arising secondarily from adenomas in the salivary gland.
  • BACKGROUND: Among the salivary gland carcinomas, carcinoma in pleomorphic adenoma has been regarded as a representative carcinoma type which arises secondarily in the background of a pre-existent benign pleomorphic adenoma.
  • It is still poorly understood how and which benign pleomorphic adenoma cells transform into its malignant form, carcinoma ex pleomorphic adenoma.
  • METHODS: We have established five cell systems from a benign pleomorphic adenoma of the parotid gland of a 61-year-old woman.
  • RESULTS: We established and characterized five cell systems (designated as SM-AP1 to SM-AP5) from a benign pleomorphic adenoma of the parotid gland.
  • Among them, der(9)t(9;13)(p13.3;q12.3) was shared by all five of the cell systems.
  • In addition, they had ductal arrangements or plasmacytoid appearances of tumor cells and myxoid or hyaline stromata, indicating some characteristics of pleomorphic adenoma.
  • The histological features of squamous cell carcinoma from the transplanted cell systems in nude mice might suggest a secondary onset of malignancy from a pre-existing benign adenoma.
  • [MeSH-major] Adenoma / metabolism. Adenoma / pathology. Carcinoma / metabolism. Carcinoma / secondary. Salivary Gland Neoplasms / metabolism. Salivary Gland Neoplasms / secondary
  • [MeSH-minor] Animals. Chromosomes, Artificial, Bacterial. DNA Mutational Analysis. Female. Genes, p53. Humans. Immunohistochemistry / methods. In Situ Hybridization, Fluorescence. Mice. Mice, Nude. Microscopy, Fluorescence / methods. Middle Aged. Neoplasm Transplantation. Tumor Cells, Cultured


76. Hong KH, Yang YS: Intraoral approach for the treatment of submandibular salivary gland mixed tumors. Oral Oncol; 2008 May;44(5):491-5
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  • [Title] Intraoral approach for the treatment of submandibular salivary gland mixed tumors.
  • Pleomorphic adenoma represents a most common benign neoplasm of major salivary glands.
  • Most occurrences of this benign tumor in the submandibular gland have been treated surgically without difficulty via transcervical approach.
  • In this study, we introduced the intraoral approach for the removal of the submandibular mixed tumor.
  • In total, 12 cases of pleomorphic adenoma of the submandibular gland were treated via intraoral approach.
  • During surgery the tumor and submandibular gland are easily dissected from surrounding tissue and removed through intraoral incision.
  • All patients were followed up for the recurrence of the tumor from 20 months to 10 years.
  • One patient showed a tumor recurrence at the early stage of this approach.
  • We propose that the benign mixed tumor of the submandibular gland could be removed easily via intraoral route without an external scar or nerve injury.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Postoperative Complications / prevention & control. Submandibular Gland / surgery. Submandibular Gland Neoplasms / surgery

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  • (PMID = 17827052.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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77. Jang YW, Kim SG, Pai H, Park JW, Lee YC, Rotaru H: Sialolipoma: case report and review of 27 cases. Oral Maxillofac Surg; 2009 Jun;13(2):109-13
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  • INTRODUCTION: This article presents a patient with sialolipoma of the submandibular gland, a rare neoplasm, and reviews related literatures.
  • DISCUSSION: We presented a sialolipoma of the submandibular gland and other 27 cases from published literatures.
  • It was the second case of submandibular gland sialolipoma reported in the English literature.
  • The most common site for the tumor was the parotid gland (17 cases, 60.7%), followed by the palate (four cases, 14.2%).
  • Histopathologically, a tumor was a benign lesion with proliferating lipocytes including scattered foci with a normal salivary gland tissue.
  • CONCLUSION: Sialolipoma is a rare benign neoplasm in the head and neck and it shows equal sex predilection.
  • [MeSH-major] Lipoma / diagnosis. Submandibular Gland Neoplasms / diagnosis
  • [MeSH-minor] Adipocytes / pathology. Female. Follow-Up Studies. Humans. Middle Aged. Salivary Ducts / pathology. Submandibular Gland / pathology. Tomography, X-Ray Computed

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  • (PMID = 19347375.001).
  • [ISSN] 1865-1550
  • [Journal-full-title] Oral and maxillofacial surgery
  • [ISO-abbreviation] Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 16
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78. Pietniczka-Załeska M, Dabrowska-Bień J: [Parotid tumors: a two-year experience of Otolaryngology Department at MSS Hospital in Warsaw]. Otolaryngol Pol; 2009 Sep;63(7):43-6
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  • THE AIM OF THE STUDY: Tumors of the salivary glands represent about 3% of head and neck neoplasms.
  • Most of theme--up to 80%--originate from the parotid gland.
  • The aim of the study is to present current epidemiological data, most frequent complains, our surgical technique, histopathological diagnosis, complications rate and follow-up.
  • All of the patients had ultrasound examination prior to operation to estimate the spread and the type of the tumor.
  • RESULTS: The frequency of incidence of benign tumours was 90% and the most frequent histopathological diagnosis was pleomorphic adenoma (49%) and adenolymphoma (42%).
  • The most frequent complication was sensory deficit about the cheek and ear (35%), temporary facial nerve paresis (5%), hematoma (1%), salivary fistula (1%).
  • CONCLUSION: Superficial and total parotidectomy are safe procedures of treatment in case of salivary gland tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Follow-Up Studies. Hospitals, Special. Humans. Male. Middle Aged. Neoplasm Staging. Oral Surgical Procedures / statistics & numerical data. Poland. Retrospective Studies. Survival Analysis. Treatment Outcome. Young Adult

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  • (PMID = 20564899.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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79. Benoit MM, Handzel O, McKenna MJ, Deschler DG: A 42-year-old man with facial nerve weakness and multiple recurrent pleomorphic adenoma. Otol Neurotol; 2010 Sep;31(7):1157-9
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  • OBJECTIVE: To describe a case and discuss the differential diagnosis of facial nerve paresis presenting years after resection of multiple recurrent parotid pleomorphic adenoma.
  • MAIN OUTCOME MEASURES: Histopathologic diagnosis and treatment outcome.
  • RESULTS: Final diagnosis of recurrent pleomorphic adenoma causing compression of the facial nerve at the stylomastoid foramen.
  • CONCLUSION: Facial nerve weakness caused by a benign salivary gland tumor is rare.
  • [MeSH-minor] Adult. Humans. Immunosuppressive Agents / therapeutic use. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local. Temporal Bone / pathology. Tomography, X-Ray Computed

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  • (PMID = 20657328.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
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80. Tagnon B, Weynand B, Reychler H: Küttner's tumour: a case report. Acta Chir Belg; 2008 Sep-Oct;108(5):621-4
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  • [Title] Küttner's tumour: a case report.
  • Küttner's tumour (chronic sclerosing sialadenitis) is a chronic inflammatory disease of the salivary glands.
  • It is a totally benign lesion.
  • However, because of its clinical features, the clinical diagnosis is often that of a salivary gland neoplasm.
  • We present a case of unilateral Küttner's tumour in the left submandibular salivary gland and discuss clinical, imaging and histological features.
  • [MeSH-major] Sialadenitis / diagnosis. Submandibular Gland / pathology. Submandibular Gland Diseases / diagnosis

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  • (PMID = 19051485.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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81. Mansueto G, Falleti J, De Cecio R, Papa F, De Rosa G: Synchronous bilateral multifocal canalicular adenoma: a case report of an unusual finding. Clin Exp Dermatol; 2009 Dec;34(8):e587-9
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  • Canalicular adenoma is a benign neoplasm of the minor salivary glands.
  • [MeSH-major] Adenoma / pathology. Nose Neoplasms / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Female. Humans. Neoplasm Recurrence, Local. Salivary Glands, Minor / pathology

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  • (PMID = 19486066.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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82. Chang T, Husain AN, Colby T, Taxy JB, Welch WR, Cheung OY, Early A, Travis W, Krausz T: Pneumocytic adenomyoepithelioma: a distinctive lung tumor with epithelial, myoepithelial, and pneumocytic differentiation. Am J Surg Pathol; 2007 Apr;31(4):562-8
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  • [Title] Pneumocytic adenomyoepithelioma: a distinctive lung tumor with epithelial, myoepithelial, and pneumocytic differentiation.
  • Pulmonary tumors with epithelial and myoepithelial differentiation are rare, thought to be of bronchial minor salivary gland origin and classified similarly to salivary gland neoplasms.
  • The biologic behavior to date has been benign.
  • This is the first reported series of a distinctive lung tumor with epithelial, myoepithelial, and pneumocytic differentiation that differs histologically from all previously recognized pulmonary salivary gland-type and pneumocytic tumors.
  • It is a unique benign appearing neoplasm for which the designation pneumocytic adenomyoepithelioma is suggested.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Female. Humans. Microscopy, Electron, Transmission. Middle Aged. Treatment Outcome

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  • (PMID = 17414103.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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83. Stodulski D, Rzepko R, Kowalska B, Stankiewicz C: [Carcinoma ex pleomorphic adenoma of major salivary glands--a clinicopathologic review]. Otolaryngol Pol; 2007;61(5):687-93
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  • [Title] [Carcinoma ex pleomorphic adenoma of major salivary glands--a clinicopathologic review].
  • BACKGROUND: Pleomorphic adenoma (PA) is the most common neoplasm of the major salivary glands.
  • There are three subtypes of malignant PA: carcinoma ex pleomorphic adenoma (CXPA); carcinosarcoma (true malignant mixed tumor) and metastasizing pleomorphic adenoma.
  • For proper diagnosis of CXPA, a statement of coexistence of pleomorphic adenoma and carcinoma (or carcinoma after prior PA surgery) is needed.
  • Own material is presented because of rarity and clinicopathologic specificity of this neoplasm.
  • The following clinical factors were evaluated: age, sex, symptoms (time of lasting, evolution), tumor size, invasion of the adjacent structures and facial nerve, neck nodes, clinical stage, treatment outcome.
  • One pathologist reviewed histological material of 18 out of 19 patients who had been operated and pathological factors such as sensitivity and accuracy of fine needle aspiration biopsy, grade, histology and proportion of malignant component in tumor, lymph nodes metastases were analyzed.
  • In 15 cases, tumor was localized in the parotid and in 4 in the submandibular gland.
  • Duration of symptoms of benign PA was from 2 to 40 years (mean 17.8 years).
  • Symptoms of malignant transformation occurred in 15 patients, the most common were rapid enlargement of tumor, pain and facial nerve palsy.
  • Tumor size varied from 2 to 20 cm with a mean of 6 cm.
  • Adjacent structures were invaded by neoplasm in 5 cases.
  • Clinical picture and histopathological examination determinate the diagnosis of CXPA.
  • The best method of prevention and treatment of CXPA is early and radical removal of all major salivary glands tumors.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma / pathology. Neoplasms, Multiple Primary / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology
  • [MeSH-minor] Biopsy, Needle. Female. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 18552001.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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84. Maruya S, Kies MS, Williams M, Myers JN, Weber RS, Batsakis JG, El-Naggar AK: Differential expression of p63 isotypes (DeltaN and TA) in salivary gland neoplasms: biological and diagnostic implications. Hum Pathol; 2005 Jul;36(7):821-7
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  • [Title] Differential expression of p63 isotypes (DeltaN and TA) in salivary gland neoplasms: biological and diagnostic implications.
  • To determine the association between the expression of p63 gene isoforms (TA and DeltaN) and salivary gland tumorigenesis, we performed reverse transcription-polymerase chain reaction analysis of these markers in 71 benign and malignant salivary gland neoplasms.
  • Both p63 isoforms were either negative or weakly expressed in normal salivary gland tissues.
  • TAp63 was highly expressed in most benign tumors and was either negative or weakly positive in most carcinomas.
  • Conversely, DeltaNp63 was negative or faintly positive in most benign neoplasms and was highly expressed in adenoid cystic, mucoepidermoid, and myoepithelial carcinomas.
  • Immunohistochemical analysis using anti-full-length p63 protein showed ubiquitous nuclear staining in basal and myoepithelial cells in both benign and malignant neoplasms.
  • JAG1 was expressed in most benign and malignant tumors and did not correlate with p63 isoforms expression.
  • We conclude that (1) p63 isoforms are differentially expressed in most benign and malignant tumors and may play distinct biological roles in certain salivary gland neoplasms;.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenolymphoma / metabolism. Adenoma, Pleomorphic / metabolism. Genes, Tumor Suppressor. Phosphoproteins / metabolism. Salivary Gland Neoplasms / metabolism. Trans-Activators / metabolism
  • [MeSH-minor] Calcium-Binding Proteins. DNA Primers / chemistry. DNA-Binding Proteins. Gene Expression Regulation, Neoplastic. Humans. Immunoenzyme Techniques. Intercellular Signaling Peptides and Proteins. Membrane Proteins / genetics. Membrane Proteins / metabolism. Protein Isoforms. RNA, Messenger / metabolism. RNA, Neoplasm / genetics. Reverse Transcriptase Polymerase Chain Reaction. Salivary Glands / metabolism. Salivary Glands / pathology. Transcription Factors. Tumor Suppressor Proteins

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  • (PMID = 16084953.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium-Binding Proteins; 0 / DNA Primers; 0 / DNA-Binding Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Membrane Proteins; 0 / Phosphoproteins; 0 / Protein Isoforms; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 134324-36-0 / Serrate proteins
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85. Shigeishi H, Yoneda S, Taki M, Nobumori T, Ohta K, Higashikawa K, Yasui W, Kamata N: Correlation of human Bub1 expression with tumor-proliferating activity in salivary gland tumors. Oncol Rep; 2006 Apr;15(4):933-8
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  • [Title] Correlation of human Bub1 expression with tumor-proliferating activity in salivary gland tumors.
  • We examined the expression of Bub1 mRNA and protein in 21 human salivary gland tumors (7 pleomorphic adenomas, 2 warthin tumors, 5 mucoepidermoid carcinomas, 3 adenoid cystic carcinomas and 4 acinic cell carcinomas) and 3 normal submandibular glands using real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) or western blotting.
  • The mean expression levels of Bub1 mRNA and protein were higher in malignant tumors (0.12+/-0.028/1.75+/-0.53) than normal submandibular glands (0.042+/-0.014/0.19+/-0.044) and benign tumors (0.058+/-0.01/0.97+/-0.44).
  • A significant correlation was found between Bub1 mRNA/protein expression and the Ki-67 labeling index in salivary gland tumors (Spearman's correlation coefficient by rank test, p=0.026/p=0.002).
  • [MeSH-major] Cell Proliferation. Protein Kinases / genetics. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adenolymphoma / genetics. Adenolymphoma / metabolism. Adenolymphoma / pathology. Adenoma, Pleomorphic / genetics. Adenoma, Pleomorphic / metabolism. Adenoma, Pleomorphic / pathology. Blotting, Western. Carcinoma, Acinar Cell / genetics. Carcinoma, Acinar Cell / metabolism. Carcinoma, Acinar Cell / pathology. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / genetics. Carcinoma, Mucoepidermoid / metabolism. Carcinoma, Mucoepidermoid / pathology. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Ki-67 Antigen / analysis. Neoplasm Staging. Proliferating Cell Nuclear Antigen / analysis. Protein-Serine-Threonine Kinases. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16525682.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen; 0 / RNA, Messenger; EC 2.7.- / Protein Kinases; EC 2.7.11.1 / BUB1 protein, human; EC 2.7.11.1 / Bub1 spindle checkpoint protein; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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86. Gierek T, Majzel K, Jura-Szołtys E, Slaska-Kaspera A, Witkowska M, Klimczak-Gołab L: [A 20-year retrospective histoclinical analysis of parotid gland tumors in the ENT Department AM in Katowice]. Otolaryngol Pol; 2007;61(4):399-403
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  • [Title] [A 20-year retrospective histoclinical analysis of parotid gland tumors in the ENT Department AM in Katowice].
  • INTRODUCTION: Salivary gland neoplasms represent the diverse group of tumours encountered by the head and neck surgeons.
  • MATERIAL AND METHODS: The study is analysis of 531 patients with parotid gland tumours in patients treated in ENT Department during 1986-2006.
  • We analysed surgical treatment and intraoperative tumour stage.
  • The results of histological diagnosis were presented.
  • RESULTS: The frequency of incidence of benign neoplasm was 80%.
  • The most frequent tumour was pleomorphic adenoma--75% and adenolymphoma--16%.
  • Malignant tumours constituted 20% of all gland tumours.
  • Mucoepidermoid (27%) and adenoid cyst (22%) carcinomas were the most common malignant tumour.
  • Tumour stages T3-T4 was in 90%.
  • [MeSH-minor] Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Mucoepidermoid / epidemiology. Carcinoma, Mucoepidermoid / pathology. Carcinoma, Mucoepidermoid / surgery. Female. Humans. Incidence. Male. Middle Aged. Neoplasm Staging. Poland / epidemiology. Retrospective Studies

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  • (PMID = 18260221.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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87. Driemel O, Kraft K, Hemmer J: Flow cytometric S-phase fraction contributes to diagnosis of diploid malignant salivary gland tumours. Int J Oral Maxillofac Surg; 2006 Oct;35(10):947-50
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  • [Title] Flow cytometric S-phase fraction contributes to diagnosis of diploid malignant salivary gland tumours.
  • DNA ploidy studies on salivary gland tumours have shown that the proportion of aneuploid cases, although confined to the malignant entities, is considerably lower than for other solid malignancies.
  • To analyse whether the S-phase fraction (SPF) may contribute to discrimination of diploid malignant from benign tumours, DNA flow cytometric data from 45 different malignant salivary gland tumours was compared with that of 121 pleomorphic adenomas.
  • All benign tumours were diploid.
  • These results show that DNA flow cytometry may contribute to diagnostic assessment in salivary gland tumours.
  • [MeSH-major] DNA, Neoplasm / analysis. Diploidy. Flow Cytometry / methods. S Phase. Salivary Gland Neoplasms / diagnosis
  • [MeSH-minor] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / genetics. Adenoma, Pleomorphic / pathology. Adult. Aged. Aged, 80 and over. Aneuploidy. Diagnosis, Differential. Epidemiologic Methods. Female. Humans. Male. Middle Aged. Salivary Glands / pathology

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  • (PMID = 16829041.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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88. Banich J, Reyes CV, Bier-Laning C: Sebaceous lymphadenoma identified by fine needle aspiration biopsy: a case report. Acta Cytol; 2007 Mar-Apr;51(2):211-3
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  • BACKGROUND: Sebaceous lymphadenoma of the parotid gland is a rare benign neoplasm.
  • This is the first reported case of fine needle aspiration biopsy (FNAB) findings for sebaceous lymphadenoma of the parotid gland.
  • It revealed lymphoid and salivary gland parenchymal cells.
  • The surgical specimen of the parotid mass confirmed the diagnosis of sebaceous lymphadenoma on the tissue section.
  • CONCLUSION: This report is the first to describe the FNAB findings of the unusual benign parotid neoplasm sebaceous lymphadenoma.
  • Though the definitive diagnosis of any parotid mass requires tissue, generally obtained via parotidectomy, an FNAB diagnosis can be useful in counseling a patient prior to definitive biopsy.
  • [MeSH-major] Adenolymphoma / pathology. Parotid Gland / pathology. Parotid Neoplasms / pathology. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Digestive System Surgical Procedures. Facial Nerve Injuries / etiology. Facial Nerve Injuries / physiopathology. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17425206.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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89. Ethunandan M, Witton R, Hoffman G, Spedding A, Brennan PA: Atypical features in pleomorphic adenoma--a clinicopathologic study and implications for management. Int J Oral Maxillofac Surg; 2006 Jul;35(7):608-12
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  • Pleomorphic adenoma is the most common salivary gland neoplasm and infrequently undergoes malignant transformation.
  • Carcinoma ex pleomorphic adenoma is typically an infiltrative neoplasm with features of cellular pleomorphism, high mitotic activity, peri-neural and vascular invasion.
  • Following a review of 100 consecutive pleomorphic adenomas removed from the major salivary glands, 4 cases with atypical histological features were found.
  • Three tumours exhibited features of dysplasia/carcinoma without evidence of extra-capsular invasion and a further case demonstrated benign vascular invasion.
  • Patients underwent a superficial parotidectomy or submandibular gland excision based on the location of the lesion.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 16540285.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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90. Araújo VC, Demasi AP, Furuse C, Altemani A, Alves VA, Freitas LL, Araújo NS: Collagen type I may influence the expression of E-cadherin and beta-catenin in carcinoma ex-pleomorphic adenoma. Appl Immunohistochem Mol Morphol; 2009 Jul;17(4):312-8
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  • Carcinoma ex-pleomorphic adenoma (CXPA) is an aggressive salivary gland malignancy, usually derived from a long-standing or a recurrent benign tumor, the pleomorphic adenoma (PA).
  • In the context of dynamic reciprocity, changes in the composition and structure of extracellular matrix proteins and cell surface receptors have been frequently associated with dysfunctional adhesion and invasive behavior of tumor cells.
  • By immunohistochemical analysis, we have demonstrated that direct contact of tumor cells with fibrillar type I collagen, particularly near the invasive front and in invasive areas prevailing small nests of CXPA cells, could be associated with reduced expression of the E-cadherin and beta-catenin adhesion molecules and with invasive behavior of epithelial, but not of CXPA with myoepithelial component.

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  • (PMID = 19276972.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cadherins; 0 / Collagen Type I; 0 / Neoplasm Proteins; 0 / beta Catenin
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91. Zhi K, Ren W, Zhou H, Wen Y, Zhang Y: Management of parapharyngeal-space tumors. J Oral Maxillofac Surg; 2009 Jun;67(6):1239-44
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  • The most common class of lesion was salivary-gland neoplasm, accounting for 74 cases (45.68%).
  • Surgical approaches were dictated by size of the tumor, its location, its relationship to the great vessels, and suspicion of malignancy.
  • The most common approach was transcervical-transparotid for benign tumors.
  • [MeSH-minor] Adenoma, Pleomorphic / surgery. Adult. Biopsy, Fine-Needle. Carcinoma / secondary. Carcinoma / surgery. Chemotherapy, Adjuvant. Cranial Nerve Diseases / etiology. Female. Follow-Up Studies. Humans. Magnetic Resonance Angiography. Magnetic Resonance Imaging. Male. Neck Muscles / surgery. Neoplasm Recurrence, Local / pathology. Parotid Gland / surgery. Postoperative Complications. Radiotherapy, Adjuvant. Retrospective Studies. Salivary Gland Neoplasms / surgery. Tomography, X-Ray Computed

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  • [CommentIn] J Oral Maxillofac Surg. 2010 May;68(5):1209-11; author reply 1212 [20403530.001]
  • (PMID = 19446210.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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92. Das DK, Haji BE, Ahmed MS, Hossain MN: Myoepithelioma of the parotid gland initially diagnosed by fine needle aspiration cytology and immunocytochemistry: a case report. Acta Cytol; 2005 Jan-Feb;49(1):65-70
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  • [Title] Myoepithelioma of the parotid gland initially diagnosed by fine needle aspiration cytology and immunocytochemistry: a case report.
  • BACKGROUND: Myoepithelioma is a rare, benign tumor of the salivary gland, most commonly affecting the parotid gland.
  • Red to purple, myxoid matrix was present as a scanty fibrillar substance and as globules surrounded by tumor cells vaguely reminiscent of adenoid cystic carcinoma.
  • Histopathology of the resected tumor and immunohistochemical staining confirmed the cytodiagnosis of myoepithelioma.
  • CONCLUSION: FNA cytologic features together with immunocytochemical studies on smears can offer a preoperative diagnosis of myoepithelioma.
  • [MeSH-major] Myoepithelioma / diagnosis. Myoepithelioma / pathology. Parotid Neoplasms / diagnosis. Parotid Neoplasms / pathology

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  • (PMID = 15717758.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S100 Proteins
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93. Zhang Y, Gomez-Fernandez CR, Jorda M, Ganjei-Azar P: Fine-needle aspiration (FNA) and pleural fluid cytology diagnosis of benign metastasizing pleomorphic adenoma of the parotid gland in the lung: a case report and review of literature. Diagn Cytopathol; 2009 Nov;37(11):828-31
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  • [Title] Fine-needle aspiration (FNA) and pleural fluid cytology diagnosis of benign metastasizing pleomorphic adenoma of the parotid gland in the lung: a case report and review of literature.
  • Lesions that contain abundant benign myoepithelial cells, including pleomorphic adenomas of salivary gland origin, may present a diagnostic challenge in fine-needle aspiration (FNA) specimens.
  • Benign metastasizing pleomorphic adenoma is a rare neoplasm, in which the benign appearing pleomorphic adenoma, without any histological evidence of malignancy, metastasizes to distant sites including lung.
  • In the absence of clinical history of a pre-existing myoepithelial neoplasm, the presence of myoepithelial cells in the lung or any other organs besides salivary glands may create diagnostic difficulty.
  • Here we present the cytologic findings of such a metastatic tumor found in the lung FNA and pleural fluid specimens from a 64-year-old woman, with a history of local recurrent salivary gland pleomorphic adenomas, who presented with multiple bilateral pulmonary nodules and pleural effusion.
  • The diagnosis of benign metastasizing pleomorphic adenoma was made based on clinical information and cytomorphology, and confirmed by immunocytochemistry.

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  • (PMID = 19582818.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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94. Sayed SI, Kazi RA, Jagade MV, Palav RS, Shinde VV, Pawar PV: A rare myoepithelioma of the sinonasal cavity: case report. Cases J; 2008;1(1):29
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  • Myoepithelioma is a rare benign neoplasm.
  • Pure accounting for less than 1% of all salivary gland tumors.
  • Diagnosis of myoepithelioma through light microscopy is possible and immunohistochemistry is done to facilitate the diagnosis.
  • We report to you a rare case of sinonasal myoepithelioma in a 57 year old Asian female.Myoepitheliomas are rare tumours that account for only about 1% of all salivary gland tumors.
  • Most are benign, but some can be malignant.

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  • [Cites] AJR Am J Roentgenol. 1999 Nov;173(5):1413-4 [10541134.001]
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  • (PMID = 18620583.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2483262
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95. Sassano P, Paparo F, Ramieri V, Colangeli W, Verdino G: Interleukine-6 (IL-6) may be a link between myasthenia gravis and myoepithelioma of the parotid gland. Med Hypotheses; 2007;68(2):314-7
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  • [Title] Interleukine-6 (IL-6) may be a link between myasthenia gravis and myoepithelioma of the parotid gland.
  • Myoepithelioma is a rare benign neoplasm of the salivary glands occurring more frequently in the parotids.
  • Myasthenia gravis (MG) is a chronic, T-cell dependent, antibody and complement-mediated autoimmune neuromuscular transmission disorder.


96. Charous DD, Cunnane MF, Rosen MR, Keane WM: Recurrent polymorphous low-grade adenocarcinoma manifesting as a sinonasal mass: a case report. Ear Nose Throat J; 2005 Jun;84(6):354, 356-7
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  • Polymorphous low-grade adenocarcinoma (PLGA) is a malignant neoplasm that tends to follow a benign clinical course.
  • [MeSH-major] Adenocarcinoma / diagnosis. Paranasal Sinus Neoplasms / diagnosis. Paranasal Sinuses / physiopathology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Humans. Male. Recurrence. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / pathology

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  • (PMID = 16075858.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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97. Gurey LE, Brook CD, Parnes SM: Pleomorphic adenoma of the infratemporal fossa: case report and literature review. Laryngoscope; 2010;120 Suppl 4:S151
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  • OBJECTIVES: To describe an unusual location for a common benign salivary gland neoplasm.
  • RESULTS: Pleomorphic adenoma has been reported to arise in such diverse locations as the nasal septum, main stem bronchus, trachea, lacrimal gland and external auditory canal.
  • Diagnosis and approach to this region is difficult considering its concealed location.

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  • (PMID = 21225749.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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98. Ceylan A, Celenk F, Poyraz A, Uslu S: Pleomorphic adenoma of the nasal columella. Pathol Res Pract; 2008;204(4):273-6
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  • Pleomorphic adenoma (mixed tumor) is the most common benign neoplasm of the salivary glands.
  • It is considered to occur primarily in the major salivary glands, such as the parotid and submandibular glands.
  • It is much less common in the minor salivary glands, and rarely occurs at other sites, such as larynx, pharynx, trachea, lacrimal gland, and sinonasal tract.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Neoplasm Recurrence, Local. Neoplasm Seeding. Nose Neoplasms / pathology

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  • (PMID = 18295980.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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99. Borzym-Kluczyk M, Olszewska E, Radziejewska I, Lewszuk A, Zwierz K: Isoenzymes of N-acetyl-beta-hexosaminidase in human pleomorphic adenoma and healthy salivary glands: a preliminary study. Clin Chem Lab Med; 2008;46(1):131-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isoenzymes of N-acetyl-beta-hexosaminidase in human pleomorphic adenoma and healthy salivary glands: a preliminary study.
  • BACKGROUND: Pleomorphic adenoma (PA) is a benign tumour of the salivary gland with a tendency to malignancy which creates many diagnostic problems.
  • N-acetyl-beta-hexosaminidase (HEX) is a lysosomal exoglycosidase involved in degradation of oligosaccharide chains of glycoproteins, glycolipids and glycosaminoglycans, known as a potential tumour marker.
  • The aim of our study was to evaluate HEX A and HEX B activity in healthy and PA human salivary glands using colorimetric and isoelectrofocusing methods.
  • METHODS: PA (n=8) and macroscopically unchanged salivary glands (n=8), served as controls, were used for the study.
  • RESULTS: Total activity of HEX, as well as HEX A and HEX B, in PA specimens determined by a colorimetric method was significantly higher compared with normal human salivary gland specimens.
  • After isoelectrofocusing, in normal human salivary and PA glands, two sets of HEX isoforms were found corresponding to HEX A and HEX B.
  • CONCLUSIONS: The present data indicate that HEX activity and activity of its isoenzymes in tumour specimens is significantly and consistently elevated, and thus suggest the need for further studies on the degradation of glycoconjugates, both in healthy salivary glands and PA.
  • It appears that HEX may be considered as a new tumour marker in these salivary gland diseases.

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  • (PMID = 18034640.001).
  • [ISSN] 1434-6621
  • [Journal-full-title] Clinical chemistry and laboratory medicine
  • [ISO-abbreviation] Clin. Chem. Lab. Med.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Isoenzymes; EC 3.2.1.52 / Hexosaminidase A; EC 3.2.1.52 / Hexosaminidase B; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
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100. Yang S, Chen X, Wang L, Zhang J: Non-sebaceous lymphadenoma of the salivary gland: case report with immunohistochemical investigation. Virchows Arch; 2007 May;450(5):595-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-sebaceous lymphadenoma of the salivary gland: case report with immunohistochemical investigation.
  • Non-sebaceous lymphadenoma (NSL) is a rare, recently described, benign salivary gland tumor characterized by a dense lymphoid infiltrate and absence of sebaceous differentiation.
  • The patient was a 50-year-old woman presenting with a slowly growing painless mass in the right parotid gland.
  • The tumor was encapsulated and measured 3 x 2 x 2 cm.
  • Microscopically, the tumor comprised islands of epithelial cells with centrally located duct-like structures within a dense lymphoid stroma.
  • Immunohistochemically, the tumor regularly expressed CKs 7, 8/18, and 19, which are typical for columnar differentiation and CKs 17 and 5/6, which are most typically expressed in basal cells of complex epithelia.
  • [MeSH-major] Lymphoma / pathology. Parotid Gland / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Female. Humans. Keratins / analysis. Middle Aged. Treatment Outcome

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  • (PMID = 17431672.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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