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1
benign neoplasm of the retina 2005:2010[pubdate] *count=100
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Items 1 to 100 of about 11536
1.
Usui S, Oveson BC, Lee SY, Jo YJ, Yoshida T, Miki A, Miki K, Iwase T, Lu L, Campochiaro PA:
NADPH oxidase plays a central role in cone cell death in retinitis pigmentosa.
J Neurochem
; 2009 Aug;110(3):1028-37
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After rods die, the level of tissue oxygen in the outer
retina
becomes elevated and there is progressive oxidative damage to cones that ultimately triggers apoptosis.
Apocynin, a blocker of Nox, but not allopurinol, a blocker of xanthine oxidase, markedly reduced the superoxide radicals visualized by hydroethidine in the outer
retina
in the
retinal
degeneration-1 (rd1(+/+)) model of RP.
Compared to rd1(+/+) mice treated with vehicle, those treated with apocynin, but not those treated with allopurinol, had significantly less oxidative damage in
the retina
measured by ELISA for carbonyl adducts.
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(PMID = 19493169.001).
[ISSN]
1471-4159
[Journal-full-title]
Journal of neurochemistry
[ISO-abbreviation]
J. Neurochem.
[Language]
ENG
[Grant]
United States / NEI NIH HHS / EY / EY005951-23; United States / NEI NIH HHS / EY / R01 EY005951; United States / NEI NIH HHS / EY / R01 EY005951-23; United States / NEI NIH HHS / EY / R01 EY05951
[Publication-type]
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
EC 1.6.3.1 / NADPH Oxidase
[Other-IDs]
NLM/ NIHMS170296; NLM/ PMC2833098
2.
Hegde GV, James J, Das AV, Zhao X, Bhattacharya S, Ahmad I:
Characterization of early retinal progenitor microenvironment: presence of activities selective for the differentiation of retinal ganglion cells and maintenance of progenitors.
Exp Eye Res
; 2007 Mar;84(3):577-90
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[Title]
Characterization of early
retinal
progenitor microenvironment: presence of activities selective for the differentiation of
retinal
ganglion cells and maintenance of progenitors.
The maintenance and differentiation of
retinal
progenitors take place in the context of the microenvironment in which they reside at a given time during
retinal
histogenesis.
To understand the nature of the microenvironment in the developing
retina
, we have examined the influence of activities present during the early stage of
retinal
histogenesis on enriched
retinal
progenitors, using the neurosphere model.
Early and late
retinal
progenitors, enriched as neurospheres from embryonic day 14 (E14) and E18 rat
retina
, respectively, were cultured in embryonic day 3 (E3) chick
retinal
conditioned medium, simulating the microenvironment present during early
retinal
histogenesis.
Examination of the differentiation and proliferation of
retinal
progenitors revealed that the early microenvironment contains at least three regulatory activities, which are partitioned in different size fractions of the conditioned medium with different heat sensitivity.
First, it is characterized by activities, present in heat stable <30 kDa fraction, that promote the differentiation of
retinal
ganglion cells (RGCs), the early born neurons.
Second, it contains activities, present in heat-sensitive >30 kDa fraction, that regulate the number of early born neurons and maintain the pool of
retinal
progenitors.
Third, it possesses activities, present in heat-sensitive <30 kDa fraction, that prevent the premature differentiation of early
retinal
progenitors into the late born neurons.
Thus, our observations demonstrate the regulatory influence of microenvironment on the maintenance and differentiation of
retinal
progenitors and establish neurospheres as a viable model system for the examination of such influences.
[MeSH-major]
Retina
/ embryology. Stem Cells / cytology
[MeSH-minor]
Animals. Cell Differentiation. Cell Division. Cells, Cultured. Coculture Techniques. Culture Media, Conditioned. Female. Gene Expression Regulation, Developmental. Immunohistochemistry / methods. Models, Animal. Photoreceptor Cells, Vertebrate / cytology. Rats. Rats, Sprague-Dawley.
Retinal
Ganglion Cells / cytology. Reverse Transcriptase Polymerase Chain Reaction
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(PMID = 17227675.001).
[ISSN]
0014-4835
[Journal-full-title]
Experimental eye research
[ISO-abbreviation]
Exp. Eye Res.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Culture Media, Conditioned
3.
Liao SD, Puro DG:
NAD+-induced vasotoxicity in the pericyte-containing microvasculature of the rat retina: effect of diabetes.
Invest Ophthalmol Vis Sci
; 2006 Nov;47(11):5032-8
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[Title]
NAD+-induced vasotoxicity in the pericyte-containing microvasculature of the rat
retina
: effect of diabetes.
PURPOSE: It was recently proposed that activation of P2X(7) purinoceptors may play a role in causing cell death in the pericyte-containing microvasculature of the diabetic
retina
.
This hypothesis is supported by the observation that diabetes enhances lethal pore formation in
retinal
microvessels exposed to synthetic P2X(7) agonists.
METHODS: Pericyte-containing
retinal
microvessels were isolated from normal and streptozotocin-injected rats.
RESULTS: In freshly isolated
retinal
microvessels, it was found that extracellular NAD(+), but not its catabolites, caused cell death (half-maximal effective concentration [EC(50)] = 2 nM) by a mechanism involving the activation of P2X(7) purinoceptors and the formation of transmembrane pores.
A series of experiments provided evidence that NAD(+), which is not a direct purinergic agonist, serves as a substrate for ecto-ribosylation reactions that subsequently trigger P2X(7)-dependent cell death in the
retinal
microvasculature.
Soon after the onset of diabetes, the sensitivity of
retinal
microvessels to the vasotoxic effect of extracellular NAD(+) increased by approximately 100-fold.
CONCLUSIONS: Purinergic vasotoxicity triggered by extracellular NAD(+) is a newly recognized mechanism that may contribute to the cell death observed in the pericyte-containing microvascular of the diabetic
retina
.
[MeSH-major]
Apoptosis / drug effects. Diabetes Mellitus, Experimental / metabolism. Diabetic Retinopathy / metabolism. NAD / toxicity. Pericytes / drug effects.
Retinal
Vessels / drug effects
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(PMID = 17065524.001).
[ISSN]
0146-0404
[Journal-full-title]
Investigative ophthalmology & visual science
[ISO-abbreviation]
Invest. Ophthalmol. Vis. Sci.
[Language]
eng
[Grant]
United States / NEI NIH HHS / EY / EY 07003; United States / NEI NIH HHS / EY / EY 12505
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Benzoxazoles; 0 / Fluorescent Dyes; 0 / P2rx7 protein, rat; 0 / Purinergic P2 Receptor Antagonists; 0 / Quinolinium Compounds; 0 / Receptors, Purinergic P2; 0 / Receptors, Purinergic P2X7; 0U46U6E8UK / NAD; 152068-09-2 / YO-PRO 1; 20762-30-5 / Adenosine Diphosphate Ribose; 38806-39-2 / 1,N(6)-ethenoadenosine diphosphate; 61D2G4IYVH / Adenosine Diphosphate; EC 2.4.2.- / ADP Ribose Transferases
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4.
Cheruvu NP, Amrite AC, Kompella UB:
Effect of eye pigmentation on transscleral drug delivery.
Invest Ophthalmol Vis Sci
; 2008 Jan;49(1):333-41
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PURPOSE: To determine the influence of eye pigmentation on transscleral
retinal
delivery of celecoxib.
The animals were euthanatized at the end of 0.25, 0.5, 1, 2, 3, 4, 8, or 12 hours after the drug was administered, and celecoxib levels in ocular tissues (sclera, choroid-RPE,
retina
, vitreous, lens, and cornea) were estimated with an HPLC assay.
The concentrations of melanin in choroid-RPE, sclera, and
retina of
BN rats were 200 +/- 30, 12 +/- 4, and 3 +/- 0.2 mug/mg tissue, respectively.
However, the
retinal
(P = 0.001) and vitreal (P = 0.001) AUCs of celecoxib in the treated eyes were approximately 1.5-fold higher in SD rats than in BN rats.
With celecoxib-poly(lactide) microparticles, choroid-RPE,
retina
, and vitreous concentrations on day 8 exhibited similar trends in differences between the two strains, with the differences being greater than those recorded for the celecoxib suspension.
CONCLUSIONS: Transscleral
retinal
and vitreal drug delivery of lipophilic celecoxib is significantly lower in pigmented rats than in albino rats.
The hindrance of
retinal
and vitreal drug delivery by the choroid-RPE in pigmented rats is also true of sustained-release microparticle systems.
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]
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[
16296723.001
]
[Cites]
Pigment Cell Res. 2000 Jun;13(3):179-84
[
10885677.001
]
(PMID = 18172110.001).
[ISSN]
0146-0404
[Journal-full-title]
Investigative ophthalmology & visual science
[ISO-abbreviation]
Invest. Ophthalmol. Vis. Sci.
[Language]
ENG
[Grant]
United States / NIDDK NIH HHS / DK / R01 DK064172; United States / NEI NIH HHS / EY / R24 EY017045-02; United States / NIDDK NIH HHS / DK / R01 DK064172-02S1; United States / NIDDK NIH HHS / DK / DK 064172; United States / NIDDK NIH HHS / DK / R01 DK064172-03; United States / NEI NIH HHS / EY / R24 EY017045; United States / NEI NIH HHS / EY / EY 017045; United States / NEI NIH HHS / EY / R03 EY013842; United States / NEI NIH HHS / EY / EY 013842
[Publication-type]
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Cyclooxygenase 2 Inhibitors; 0 / Drug Carriers; 0 / Melanins; 0 / Polymers; 0 / Pyrazoles; 0 / Sulfonamides; 0 / polylactic acid-polyglycolic acid copolymer; 26009-03-0 / Polyglycolic Acid; 33X04XA5AT / Lactic Acid; JCX84Q7J1L / Celecoxib
[Other-IDs]
NLM/ NIHMS367015; NLM/ PMC3324932
5.
Mora-Ferrer C, Neumeyer C:
Neuropharmacology of vision in goldfish: a review.
Vision Res
; 2009 May;49(9):960-9
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The goldfish is one of the few animals exceptionally well analyzed in behavioral experiments and also in electrophysiological and neuroanatomical investigations of the
retina
.
To get insight into the functional organization of the
retina
we studied color vision, motion detection and temporal resolution before and after intra-ocular injection of neuropharmaca with known effects on
retinal
neurons.
[MeSH-major]
Goldfish / physiology. Neurotransmitter Agents / pharmacology.
Retina
/ physiology. Vision, Ocular / physiology
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(PMID = 18768148.001).
[ISSN]
1878-5646
[Journal-full-title]
Vision research
[ISO-abbreviation]
Vision Res.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / Neurotransmitter Agents; 56-12-2 / gamma-Aminobutyric Acid; N9YNS0M02X / Acetylcholine; TE7660XO1C / Glycine; VTD58H1Z2X / Dopamine
6.
Kamphuis W, Dijk F, Bergen AA:
Ischemic preconditioning alters the pattern of gene expression changes in response to full retinal ischemia.
Mol Vis
; 2007;13:1892-901
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[Title]
Ischemic preconditioning alters the pattern of gene expression changes in response to full
retinal
ischemia.
PURPOSE: Ischemic conditions in
the retina
have been implicated in several retinopathological conditions.
Experimentally induced ischemia for 60 min followed by reperfusion leads to a loss of neurons in the inner
retina
.
In contrast, a 5 min ischemic episode triggers a series of alterations that protect
the retina
against the damaging effects of a subsequent 60 min ischemic insult.
To study the changes altered by IPC, we assessed the gene expression patterns in the rat
retina
after ischemia (60 min) followed by reperfusion (I/R) and compared these to the gene expression patterns after ischemia/reperfusion in preconditioned animals (IPC-I/R).
Our observations indicate that activation of translational activity may be a mediator of ischemia-associated damage in
the retina
, and IPC may prevent activation of this mechanism.
[MeSH-major]
Gene Expression Regulation. Ischemia / metabolism. Ischemic Preconditioning.
Retinal
Vessels
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(PMID = 17960128.001).
[ISSN]
1090-0535
[Journal-full-title]
Molecular vision
[ISO-abbreviation]
Mol. Vis.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
9014-25-9 / RNA, Transfer; EC 6.1.1.- / Amino Acyl-tRNA Synthetases
7.
Albanna W, Banat M, Albanna N, Alnawaiseh M, Siapich SA, Igelmund P, Weiergräber M, Lüke M, Schneider T:
Longer lasting electroretinographic recordings from the isolated and superfused murine retina.
Graefes Arch Clin Exp Ophthalmol
; 2009 Oct;247(10):1339-52
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[Title]
Longer lasting electroretinographic recordings from the isolated and superfused murine
retina
.
BACKGROUND: Analysis of
retinal
signaling in mutant mice has become a powerful tool for studying
retinal
function and disease.
Previous attempts to record from isolated mouse
retina
have been limited to short time periods (about 90 min).
We performed a series of recordings from isolated mouse
retina
under a number of different conditions in order to determine the optimal parameters for this species.
METHODS: We used a superfused vertebrate
retina
assay, for which the murine
retina
had to be isolated with specific tools.
RESULTS: To improve the sensitivity and stability of photoreceptor and
retinal
network responses from the isolated and superfused murine
retina
, two different nutrient solutions from rat (physiological Ca(2+)) and bovine (reduced Ca(2+) but increased phosphate buffering capacity) were used.
CONCLUSION: In conclusion, the isolated murine
retina
can be used as a pharmacological testing system, which provides the additional advantage of selective gene inactivation for better understanding of
retinal
signalling.
[MeSH-major]
Electroretinography. Mice.
Retina
/ physiology
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]
(PMID = 19629513.001).
[ISSN]
1435-702X
[Journal-full-title]
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
[ISO-abbreviation]
Graefes Arch. Clin. Exp. Ophthalmol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Germany
[Chemical-registry-number]
0 / Calcium Channel Blockers; 0 / Solutions; 696BNE976J / nickel chloride; 7OV03QG267 / Nickel; S88TT14065 / Oxygen; YO1UK1S598 / Isradipine
8.
Sanders EJ, Lin WY, Parker E, Harvey S:
Growth hormone expression and neuroprotective activity in a quail neural retina cell line.
Gen Comp Endocrinol
; 2010 Jan 1;165(1):111-9
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[Title]
Growth hormone expression and neuroprotective activity in a quail neural
retina
cell line.
We have previously shown that growth hormone (GH) is produced within cells of the chick embryo
retina
where it appears to act as an autocrine/paracrine anti-apoptotic factor in the regulation of programmed cell death during
retinal
development.
These investigations were carried out on cultured chick embryo
retinal
ganglion cells (RGCs) as well as on the chick embryo
retina
in ovo, using GH protein knock-down by immunoneutralization.
We have now investigated the putative neuroprotective actions of GH using a quail embryo neural
retina
cell line (QNR/D) treated with GH siRNA to silence the local synthesis of GH.
We now show that knock-down of GH by gene silencing in cells of this cultured embryonic neural
retina
cell line, using NR-cGH-1 siRNA, correlates with the increased appearance in the cultures of cells with apoptotic nuclear morphology.
We thus validate, using different technology and a different culture system, our contention that GH, produced locally by cells of the neural
retina
acts in an autocrine or paracrine manner to regulate cell survival in
the retina
.
[MeSH-major]
Gene Expression Regulation. Growth Hormone / metabolism.
Retina
/ cytology.
Retina
/ metabolism.
Retinal
Ganglion Cells / metabolism
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(PMID = 19539627.001).
[ISSN]
1095-6840
[Journal-full-title]
General and comparative endocrinology
[ISO-abbreviation]
Gen. Comp. Endocrinol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / RNA, Small Interfering; 9002-72-6 / Growth Hormone
9.
See AW, Clagett-Dame M:
The temporal requirement for vitamin A in the developing eye: mechanism of action in optic fissure closure and new roles for the vitamin in regulating cell proliferation and adhesion in the embryonic retina.
Dev Biol
; 2009 Jan 1;325(1):94-105
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[Title]
The temporal requirement for vitamin A in the developing eye: mechanism of action in optic fissure closure and new roles for the vitamin in regulating cell proliferation and adhesion in the embryonic
retina
.
The optic fissure does not close in late VAD embryos, and severe folding and collapse of the
retina
is observed at E18.5.
Surprisingly, ROL given as late as E13.5 completely prevents folding of the
retina
despite the presence of an open fetal fissure, showing that coloboma and
retinal
folding represent distinct VAD-dependent defects.
Retinal
folding due to VAD is preceded by an overall reduction in the percentage of cyclin D1 positive cells in the developing
retina
, (initially resulting in
retinal
thinning), as well as a dramatic reduction in the cell adhesion-related molecules, N-cadherin and beta-catenin.
Reduction of
retinal
cell number combined with a loss of the normal cell-cell adhesion proteins may contribute to the collapse and folding of the
retina
that occurs in late VAD fetuses.
[MeSH-major]
Retina
/ cytology.
Retina
/ embryology. Vitamin A / metabolism
[MeSH-minor]
Animals. Basement Membrane / drug effects. Basement Membrane / pathology. Cadherins / metabolism. Cell Adhesion / drug effects. Cell Death / drug effects. Cell Differentiation / drug effects. Cell Proliferation / drug effects. Coloboma / complications. Coloboma / embryology. Coloboma / genetics. Cyclin D1 / metabolism. Down-Regulation / drug effects. Embryo, Mammalian / abnormalities. Embryo, Mammalian / drug effects. Fetus / abnormalities. Fetus / drug effects. Gene Expression Regulation, Developmental / drug effects. Homeodomain Proteins / genetics. Homeodomain Proteins / metabolism. RNA, Messenger / genetics. RNA, Messenger / metabolism. Rats.
Retinal
Ganglion Cells / cytology.
Retinal
Ganglion Cells / drug effects. Time Factors. Transcription Factors / genetics. Transcription Factors / metabolism. Vitamin A Deficiency / embryology. Vitamin A Deficiency / genetics. beta Catenin / metabolism
MedlinePlus Health Information.
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(PMID = 18955041.001).
[ISSN]
1095-564X
[Journal-full-title]
Developmental biology
[ISO-abbreviation]
Dev. Biol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
[Publication-country]
United States
[Chemical-registry-number]
0 / Cadherins; 0 / Homeodomain Proteins; 0 / RNA, Messenger; 0 / Transcription Factors; 0 / beta Catenin; 11103-57-4 / Vitamin A; 136601-57-5 / Cyclin D1; 184787-43-7 / homeobox protein PITX2
10.
Gunnersen JM, Kuek A, Phipps JA, Hammond VE, Puthussery T, Fletcher EL, Tan SS:
Seizure-related gene 6 (Sez-6) in amacrine cells of the rodent retina and the consequence of gene deletion.
PLoS One
; 2009;4(8):e6546
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[Title]
Seizure-related gene 6 (Sez-6) in amacrine cells of the rodent
retina
and the consequence of gene deletion.
BACKGROUND: Seizure-related gene 6 (Sez-6) is expressed in neurons of the mouse brain,
retina
and spinal cord.
METHODOLOGY/PRINCIPAL FINDINGS: The distribution pattern of Sez-6 in
the retina
was studied using a polyclonal antibody that detects the multiple isoforms of Sez-6.
Prominent immunostaining was detected in GABAergic, but not in AII glycinergic, amacrine cell subpopulations of the rat and mouse
retina
.
In order to assess the role of Sez-6 in
the retina
, we analyzed the morphology of the Sez-6 knockout mouse
retina
with immunohistochemical markers and compared ganglion cell dendritic arbor patterning in Sez-6 null retinae with controls.
CONCLUSIONS: In summary, we have reported the detailed expression pattern of a novel
retinal
marker with broad cell specificity, useful for
retinal
characterization in rodent experimental models.
Retinal
morphology, ganglion cell dendritic branching and ERG waveforms appeared normal in the Sez-6 knockout mouse suggesting that, in spite of widespread expression of Sez-6,
retinal
function in the absence of Sez-6 is not affected.
[MeSH-major]
Amacrine Cells / metabolism. Gene Deletion. Nerve Tissue Proteins / genetics.
Retina
/ metabolism
Gene Ontology.
gene/protein/disease-specific - Gene Ontology annotations from this paper
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[ISSN]
1932-6203
[Journal-full-title]
PloS one
[ISO-abbreviation]
PLoS ONE
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Nerve Tissue Proteins; 0 / Sez-6 protein, rat; 0 / Sez6 protein, mouse
[Other-IDs]
NLM/ PMC2718829
11.
Livne-Bar I, Pacal M, Cheung MC, Hankin M, Trogadis J, Chen D, Dorval KM, Bremner R:
Chx10 is required to block photoreceptor differentiation but is dispensable for progenitor proliferation in the postnatal retina.
Proc Natl Acad Sci U S A
; 2006 Mar 28;103(13):4988-93
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[Title]
Chx10 is required to block photoreceptor differentiation but is dispensable for progenitor proliferation in the postnatal
retina
.
In the Chx10-null ocular retardation (or(J)) mouse,
retinal
progenitor cell (RPC) proliferation is impaired, and bipolar neurons, a late born cell type, fail to differentiate.
In the Chx10 null or(J)
retina
, only a small fraction of cells expressing mutated Chx10 mRNA were rods, but this fraction increased after p27(Kip1) inactivation, which partially rescues proliferation.
Most significantly, acute Chx10 knockdown in the postnatal
retina
promoted rods in place of bipolar neurons without affecting division.
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.
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.
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gene/protein/disease-specific - KOMP Repository
(subscription/membership/fee required).
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Brain Res Mol Brain Res. 2000 May 31;78(1-2):26-37
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10891582.001
]
(PMID = 16547132.001).
[ISSN]
0027-8424
[Journal-full-title]
Proceedings of the National Academy of Sciences of the United States of America
[ISO-abbreviation]
Proc. Natl. Acad. Sci. U.S.A.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Homeodomain Proteins; 0 / RNA, Messenger; 0 / Transcription Factors; 0 / Vsx2 protein, mouse
[Other-IDs]
NLM/ PMC1458782
12.
Lohr HR, Kuntchithapautham K, Sharma AK, Rohrer B:
Multiple, parallel cellular suicide mechanisms participate in photoreceptor cell death.
Exp Eye Res
; 2006 Aug;83(2):380-9
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In previous experiments, analyzing gene expression in the degenerating rd/rd mouse
retina
, we have suggested that the gene defect leads to oxidative stress and altered metabolism, which may induce caspase-dependent and caspase-independent cell death mechanisms such as the activation of cystein-proteases, lysosomal proteases, autophagy and complement-mediated lysis.
The presence of the marker genes was verified by laser capture microdissection, and apoptosis (caspase activity) and autophagy (lysozyme and cathepsin activity) were verified in
retina
extracts.
The temporal pattern of the different pathways suggests that the non-caspase-dependent mechanisms may actively participate in the demise of the photoreceptors, rather than represent a passive response of the
retina
to the presence of dying cells.
[MeSH-major]
Cell Death / physiology. Photoreceptor Cells, Vertebrate / physiology.
Retinal
Degeneration / physiopathology
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[CommentIn]
Autophagy. 2007 Jan-Feb;3(1):65-6
[
17102584.001
]
[ErratumIn]
Exp Eye Res. 2006 Dec;83(6):1522
(PMID = 16626700.001).
[ISSN]
0014-4835
[Journal-full-title]
Experimental eye research
[ISO-abbreviation]
Exp. Eye Res.
[Language]
eng
[Grant]
United States / NIDCR NIH HHS / DE / DE-FG02-01ER63121; United States / NEI NIH HHS / EY / EY-13520; United States / NEI NIH HHS / EY / EY-14793
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
[Publication-country]
England
[Chemical-registry-number]
0 / Genetic Markers; EC 3.2.1.17 / Muramidase; EC 3.4.22.36 / Caspase 1
13.
Noma H, Funatsu H, Mimura T, Hori S:
Changes of vascular endothelial growth factor after vitrectomy for macular edema secondary to retinal vein occlusion.
Eur J Ophthalmol
; 2008 Nov-Dec;18(6):1017-9
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[Title]
Changes of vascular endothelial growth factor after vitrectomy for macular edema secondary to
retinal
vein occlusion.
PURPOSE: To examine whether vitrectomy combined with
retinal
photocoagulation reduces the vitreous level of vascular endothelial growth factor (VEGF) in patients with macular edema associated with
retinal
vein occlusion (RVO).
During vitrectomy,
retinal
photocoagulation was performed on the ischemic region of the
retina
in all cases (mean of 510 shots).
CONCLUSIONS: The results suggest that the vitreous levels of VEGF may be reduced by vitrectomy combined with
retinal
photocoagulation for macular edema with RVO.
It may be important to reduce the vitreous levels of VEGF by vitrectomy and
retinal
photocoagulation for ischemic
retina
in macular edema with RVO.
[MeSH-major]
Macular Edema / metabolism. Macular Edema / surgery.
Retinal
Vein Occlusion / metabolism. Vascular Endothelial Growth Factor A / metabolism. Vitrectomy. Vitreous Body / metabolism
Genetic Alliance.
consumer health - Edema
.
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(PMID = 18988180.001).
[ISSN]
1120-6721
[Journal-full-title]
European journal of ophthalmology
[ISO-abbreviation]
Eur J Ophthalmol
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
14.
Wielgus AR, Chignell CF, Miller DS, Van Houten B, Meyer J, Hu DN, Roberts JE:
Phototoxicity in human retinal pigment epithelial cells promoted by hypericin, a component of St. John's wort.
Photochem Photobiol
; 2007 May-Jun;83(3):706-13
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[Title]
Phototoxicity in human
retinal
pigment epithelial cells promoted by hypericin, a component of St. John's wort.
To determine if hypericin might also be phototoxic to the human
retina
, we exposed human
retinal
pigment epithelial (hRPE) cells to 10(-7) to 10(-5) M hypericin.
Thus, ingested SJW is potentially phototoxic to
the retina
and could contribute to
retinal
or early macular degeneration.
Hazardous Substances Data Bank.
PERYLENE
.
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(PMID = 17576381.001).
[ISSN]
0031-8655
[Journal-full-title]
Photochemistry and photobiology
[ISO-abbreviation]
Photochem. Photobiol.
[Language]
ENG
[Grant]
United States / Intramural NIH HHS / /
[Publication-type]
Journal Article; Research Support, N.I.H., Intramural
[Publication-country]
United States
[Chemical-registry-number]
5QD5427UN7 / Perylene; 7V2F1075HD / hypericin; GAN16C9B8O / Glutathione
[Other-IDs]
NLM/ NIHMS18993; NLM/ PMC2092452
15.
Larrosa JM, Polo V, Pérez-Iñigo A, Ferreras A, García-Feijoó J, Antón A, Honrubia FM:
[Optic nerve head parameters as measured by confocal scanning laser (Heidelberg Retina Tomograph II) in normal, ocular hypertensive and glaucomatous subjects].
Arch Soc Esp Oftalmol
; 2008 Jul;83(7):407-15
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[Title]
[Optic nerve head parameters as measured by confocal scanning laser (Heidelberg
Retina
Tomograph II) in normal, ocular hypertensive and glaucomatous subjects].
[Transliterated title]
Estudio
de
los parámetros
de la
cabeza del nervio óptico en sujetos normales, hipertensos oculares y glaucomatosos obtenidos mediante láser confocal
de
barrido (Heidelberg
Retina
Tomograph II).
No differences were found between normal subjects and those with ocular hypertension in mean
retinal
nerve fiber layer thickness (0.24/0.24) or between those with ocular hypertension and glaucoma in mean cup depth (0.28/0.3).
[MeSH-minor]
Adult. Aged. Aged, 80 and over. Anthropometry / instrumentation. Anthropometry / methods.
Diagnosis
, Differential. Female. Humans. Intraocular Pressure. Male. Middle Aged. Pupil. Reference Values. Visual Field Tests
MedlinePlus Health Information.
consumer health - Glaucoma
.
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(PMID = 18592440.001).
[ISSN]
0365-6691
[Journal-full-title]
Archivos de la Sociedad Española de Oftalmología
[ISO-abbreviation]
Arch Soc Esp Oftalmol
[Language]
spa
[Publication-type]
Clinical Trial; Comparative Study; English Abstract; Journal Article
[Publication-country]
Spain
16.
Kuras A, Baginskas A, Batuleviciene V:
Suprathreshold excitation of network of frog tectal neurons by discharging of single retina moving-edge detector.
Medicina (Kaunas)
; 2005;41(11):949-56
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[Title]
Suprathreshold excitation of network of frog tectal neurons by discharging of single
retina
moving-edge detector.
OBJECTIVE: It has been shown that discharge of single darkness detector in the frog
retina
can lead to suprathreshold excitation of the tectal neurons.
MATERIAL AND METHODS: The discharge of a single
retina
ganglion cell was elicited by the electrical stimulation.
RESULTS: The obtained data have suggested that a discharge of a single
retinal
moving-edge detector elicits a suprathreshold excitation of tectal neurons.
[MeSH-major]
Neurons / physiology.
Retina
/ physiology.
Retinal
Ganglion Cells / physiology
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(PMID = 16333218.001).
[ISSN]
1648-9144
[Journal-full-title]
Medicina (Kaunas, Lithuania)
[ISO-abbreviation]
Medicina (Kaunas)
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Lithuania
[Chemical-registry-number]
0 / Excitatory Amino Acid Antagonists; H030S2S85J / Kynurenic Acid
17.
Lima VM, Piqueira JR, Hanke W:
The synergetic modulation of the excitability of central gray matter by a neuropeptide: two protocols using excitation waves in chick retina.
An Acad Bras Cienc
; 2009 Mar;81(1):39-49
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[Title]
The synergetic modulation of the excitability of central gray matter by a neuropeptide: two protocols using excitation waves in chick
retina
.
The isolated chick
retina
provides an in vitro tissue model, in which two protocols were developed to verify the efficacy of a peptide in the excitability control of the central gray matter.
[MeSH-major]
Membrane Potentials / physiology. Neurons / physiology. Periaqueductal Gray / physiology. Potassium / metabolism.
Retina
/ physiology. Somatostatin / pharmacology
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consumer health - Potassium
.
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POTASSIUM, ELEMENTAL
.
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(PMID = 19274330.001).
[ISSN]
1678-2690
[Journal-full-title]
Anais da Academia Brasileira de Ciências
[ISO-abbreviation]
An. Acad. Bras. Cienc.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Brazil
[Chemical-registry-number]
51110-01-1 / Somatostatin; RWP5GA015D / Potassium
18.
Struik ML, Yazulla S, Kamermans M:
Cannabinoid agonist WIN 55212-2 speeds up the cone response to light offset in goldfish retina.
Vis Neurosci
; 2006 Mar-Apr;23(2):285-93
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[Title]
Cannabinoid agonist WIN 55212-2 speeds up the cone response to light offset in goldfish
retina
.
These data suggest that a
retinal
mechanism may account for some of the psychophysical effects of cannabis.
Whole-cell patch-clamp recordings were made from cones in the isolated goldfish
retina
.
[MeSH-major]
Adaptation, Ocular / physiology. Cannabinoids / agonists. Light. Morpholines / pharmacology. Naphthalenes / pharmacology.
Retina
/ cytology.
Retinal
Cone Photoreceptor Cells / drug effects
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(PMID = 16638179.001).
[ISSN]
0952-5238
[Journal-full-title]
Visual neuroscience
[ISO-abbreviation]
Vis. Neurosci.
[Language]
eng
[Grant]
United States / NEI NIH HHS / EY / R01 EY001682
[Publication-type]
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Benzoxazines; 0 / Cannabinoids; 0 / Morpholines; 0 / Naphthalenes; 134959-51-6 / Win 55212-2
19.
Fischer AJ, Scott MA, Tuten W:
Mitogen-activated protein kinase-signaling stimulates Müller glia to proliferate in acutely damaged chicken retina.
Glia
; 2009 Jan 15;57(2):166-81
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[Title]
Mitogen-activated protein kinase-signaling stimulates Müller glia to proliferate in acutely damaged chicken
retina
.
Müller glia in the mature
retina
have the capacity to become progenitor-like cells in a many different vertebrate classes.
The purpose of this study was to investigate the roles of the Mitogen-Activated Protein Kinase (MAPK) pathway in regulating the activity of Müller glia in the chicken
retina
.
In response to acute
retinal
damage, we found that Müller glia accumulated phosphorylated ERK1/2 and phospho-CyclicAMP Response Element Binding-protein (pCREB), and transiently expressed immediate early genes, cFos and Egr1, that are known to be downstream of MAPK-signaling.
Egr1 and pCREB were normally expressed by
retinal
progenitors in the circumferential marginal zone (CMZ), whereas cFos and pERK1/2 were not.
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(PMID = 18709648.001).
[ISSN]
1098-1136
[Journal-full-title]
Glia
[ISO-abbreviation]
Glia
[Language]
ENG
[Grant]
United States / NEI NIH HHS / EY / EY016043-03; United States / NEI NIH HHS / EY / R01 EY016043; United States / NEI NIH HHS / EY / T35 EY007151; United States / NEI NIH HHS / EY / R01 EY016043-03
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
United States
[Chemical-registry-number]
0 / Butadienes; 0 / Cyclic AMP Response Element-Binding Protein; 0 / Early Growth Response Protein 1; 0 / Nitriles; 0 / Proto-Oncogene Proteins c-fos; 0 / Pyrroles; 0 / Receptors, Fibroblast Growth Factor; 0 / SU 5402; 0 / U 0126; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3; EC 2.7.12.2 / MAP Kinase Kinase 1
[Other-IDs]
NLM/ NIHMS65202; NLM/ PMC2774719
20.
Mizuno S, Nishiwaki A, Morita H, Miyake T, Ogura Y:
Effects of periocular administration of triamcinolone acetonide on leukocyte-endothelium interactions in the ischemic retina.
Invest Ophthalmol Vis Sci
; 2007 Jun;48(6):2831-6
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[Title]
Effects of periocular administration of triamcinolone acetonide on leukocyte-endothelium interactions in the ischemic
retina
.
PURPOSE: Recent studies have reported that intravitreal or posterior sub-Tenon's injection of triamcinolone acetonide (TA) is effective in the treatment of macular edema resulting from
retinal
microcirculatory disturbances such as diabetic retinopathy and
retinal
vein occlusion.
The effects of periocular administration of TA on leukocyte-endothelium interactions were studied after transient
retinal
ischemia.
METHODS: Transient
retinal
ischemia was induced by temporary ligation of the optic nerve sheath for 60 minutes in male Long-Evans rats.
Leukocyte dynamics were evaluated in the
retinal
microcirculation using acridine orange digital fluorography.
Also,
retinal
thickness was studied by using optical coherence tomography and a histologic METHOD: The
retinal
mRNA expression of P-selectin and intercellular adhesion molecule (ICAM)-1 was semiquantitatively studied with RT-PCR.
RESULTS: The leukocytes rolling along
retinal
vein linings increased after ischemia in the vehicle-treated rats (32.5 +/- 2.1 cells/min).
The treatment decreased the
retinal
thickness and the mRNA expression of P-selectin and ICAM-1.
CONCLUSIONS: The present study demonstrated that the periocular injection of TA effectively decreased
retinal
thickness and inhibited leukocyte-endothelium interactions in
the retina
after ischemia.
Downregulation of adhesion molecules of
retinal
vascular endothelium induced by TA may play a role in the course.
[MeSH-major]
Endothelium, Vascular / metabolism. Glucocorticoids / administration & dosage. Ischemia / complications. Leukocytes / metabolism. Macular Edema / drug therapy.
Retinal
Vessels. Triamcinolone Acetonide / administration & dosage
[MeSH-minor]
Acridine Orange. Animals. Cell Communication / drug effects. Disease Models, Animal. Fluorescent Dyes. Gene Expression. Injections. Intercellular Adhesion Molecule-1 / genetics. Male. P-Selectin / genetics. RNA, Messenger / metabolism. Rats. Rats, Long-Evans.
Retinal
Diseases / complications. Reverse Transcriptase Polymerase Chain Reaction
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(PMID = 17525219.001).
[ISSN]
0146-0404
[Journal-full-title]
Investigative ophthalmology & visual science
[ISO-abbreviation]
Invest. Ophthalmol. Vis. Sci.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Fluorescent Dyes; 0 / Glucocorticoids; 0 / P-Selectin; 0 / RNA, Messenger; 126547-89-5 / Intercellular Adhesion Molecule-1; F30N4O6XVV / Acridine Orange; F446C597KA / Triamcinolone Acetonide
21.
Lecchi M, McIntosh JM, Bertrand S, Safran AB, Bertrand D:
Functional properties of neuronal nicotinic acetylcholine receptors in the chick retina during development.
Eur J Neurosci
; 2005 Jun;21(11):3182-8
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[Title]
Functional properties of neuronal nicotinic acetylcholine receptors in the chick
retina
during development.
Acetylcholine (ACh) has been recognized for a long time as a major neurotransmitter in
the retina
, however, little is known about the contribution of acetylcholine receptors in synaptic processing.
To address this question further, we examined the physiological and pharmacological properties of neuronal nicotinic acetylcholine receptors (nAChRs) in
retinal
ganglion cells from embryonic (E) 12-18-day-old Leghorn chicks.
These data demonstrate that ganglion cells of the chick
retina
express multiple receptor subtypes that progressively develop as a function
of retina
maturation.
[MeSH-major]
Cell Differentiation / physiology. Receptors, Nicotinic / metabolism.
Retina
/ embryology.
Retinal
Ganglion Cells / metabolism. Synapses / metabolism. Synaptic Transmission / physiology
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(PMID = 15978026.001).
[ISSN]
0953-816X
[Journal-full-title]
The European journal of neuroscience
[ISO-abbreviation]
Eur. J. Neurosci.
[Language]
eng
[Grant]
United States / NIMH NIH HHS / MH / MH53631
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
[Publication-country]
France
[Chemical-registry-number]
0 / Bridged Bicyclo Compounds, Heterocyclic; 0 / Conotoxins; 0 / Nicotinic Agonists; 0 / Pyridines; 0 / Receptors, Nicotinic; 0 / alpha-conotoxin MII; 0 / nicotinic receptor alpha3beta2; 0 / nicotinic receptor alpha6; M6K314F1XX / epibatidine; N9YNS0M02X / Acetylcholine
22.
Setzu A, Lathia JD, Zhao C, Wells K, Rao MS, Ffrench-Constant C, Franklin RJ:
Inflammation stimulates myelination by transplanted oligodendrocyte precursor cells.
Glia
; 2006 Sep;54(4):297-303
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We have addressed this issue using a model in which OPCs transplanted into the adult rat
retina
myelinate
retinal
ganglion cell axons around the point of injection.
Inflammation (characterized by increased expression of the macrophage marker ED1 and the astrocyte marker GFAP, and the up-regulation of multiple cytokines) was induced in
the retina
by the administration of the TLR-2 ligand zymosan.
Myelination, revealed by MBP+ myelin sheaths, was substantially increased when OPCs were injected into the inflamed
retina
compared to that achieved following transplantation into the normal, noninflamed
retina
.
[MeSH-minor]
Animals. Animals, Newborn. Biomarkers. Cell Transplantation / physiology. Cerebral Cortex / cytology. Glial Fibrillary Acidic Protein / metabolism. Immunohistochemistry. Lens, Crystalline / injuries. Ligands. Nerve Fibers / physiology. Oligonucleotide Array Sequence Analysis. Rats. Rats, Inbred F344.
Retina
/ cytology. Toll-Like Receptor 2 / drug effects. Zymosan
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(PMID = 16856149.001).
[ISSN]
0894-1491
[Journal-full-title]
Glia
[ISO-abbreviation]
Glia
[Language]
eng
[Grant]
United Kingdom / Multiple Sclerosis Society / / 689
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers; 0 / Glial Fibrillary Acidic Protein; 0 / Ligands; 0 / Tlr2 protein, rat; 0 / Toll-Like Receptor 2; 9010-72-4 / Zymosan
23.
Garcá M, Ruiz-Ederra J, Hernández-Barbáchano H, Vecino E:
Topography of pig retinal ganglion cells.
J Comp Neurol
; 2005 Jun 13;486(4):361-72
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[Title]
Topography of pig
retinal
ganglion cells.
In the present work we analyzed the distribution of
retinal
ganglion cells (RGCs) in the pig
retina
.
Different regions of the porcine
retina
were identified following analysis of the distribution of RGCs in terms of cell density and soma size: in the central
retina
, we found a high-density horizontal RGC band lying dorsal to the optic disc.
From the central to the more peripheral
retina
, we observed a decrease in RGC density, together with a greater presence of RGCs with larger somas.
The results of this study should prove to be useful as a foundation for future studies with the porcine
retina
as a model in ophthalmic research.
[MeSH-major]
Retina
/ cytology.
Retinal
Ganglion Cells / cytology
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(PMID = 15846788.001).
[ISSN]
0021-9967
[Journal-full-title]
The Journal of comparative neurology
[ISO-abbreviation]
J. Comp. Neurol.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / 2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt; 0 / Stilbamidines
24.
Hufnagel RB, Le TT, Riesenberg AL, Brown NL:
Neurog2 controls the leading edge of neurogenesis in the mammalian retina.
Dev Biol
; 2010 Apr 15;340(2):490-503
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[Title]
Neurog2 controls the leading edge of neurogenesis in the mammalian
retina
.
In the mammalian
retina
, neuronal differentiation begins in the dorso-central optic cup and sweeps peripherally and ventrally.
In this study, we evaluate the expression and function of proneural bHLH transcription factors during the onset of mouse
retinal
neurogenesis.
Dorso-central
retinal
progenitor cells that give rise to the first postmitotic neurons express Neurog2/Ngn2 and Atoh7/Math5.
However, neurogenesis is eventually restored, and at birth Neurog2 mutant retinas are reduced in size, with only a slight increase in the
retinal
ganglion cell population.
Together, this study supports the hypothesis that the intrinsic factors Neurog2 and Ascl1 regulate the temporal progression of
retinal
neurogenesis by directing overlapping waves of neuron formation.
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[Copyright]
Copyright (c) 2010 Elsevier Inc. All rights reserved.
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(PMID = 20144606.001).
[ISSN]
1095-564X
[Journal-full-title]
Developmental biology
[ISO-abbreviation]
Dev. Biol.
[Language]
ENG
[Grant]
United States / NEI NIH HHS / EY / EY013612-09A1; United States / NEI NIH HHS / EY / R01 EY013612-09A1; United States / NEI NIH HHS / EY / R01 EY018097; United States / NEI NIH HHS / EY / R01 EY013612; United States / NEI NIH HHS / EY / EY13612; United States / NEI NIH HHS / EY / EY18097
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Nerve Tissue Proteins; 0 / Neurog2 protein, mouse; 147336-22-9 / Green Fluorescent Proteins; EC 3.2.1.23 / beta-Galactosidase
[Other-IDs]
NLM/ NIHMS178692; NLM/ PMC2854206
25.
Surace EM, Auricchio A:
Versatility of AAV vectors for retinal gene transfer.
Vision Res
; 2008 Feb;48(3):353-9
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[Title]
Versatility of AAV vectors for
retinal
gene transfer.
Gene therapy represents a promising therapeutic option for many inherited and acquired
retinal
diseases.
Recombinant adeno-associated viral vectors (AAV) are the most efficient tools to transfer genes in vivo to
the retina
.
The results from the forthcoming trials with AAV in
the retina
of patients with Leber Congenital Amaurosis will be critical for the rapid development of AAV-based therapeutics for
retinal
diseases.
[MeSH-major]
Dependovirus / genetics. Eye Diseases, Hereditary / therapy. Gene Transfer Techniques. Genetic Vectors.
Retinal
Diseases / therapy
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.
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(PMID = 17923143.001).
[ISSN]
0042-6989
[Journal-full-title]
Vision research
[ISO-abbreviation]
Vision Res.
[Language]
eng
[Grant]
United States / NEI NIH HHS / EY / R01 EY015136; Italy / Telethon / / TGM06C03; Italy / Telethon / / TGM06S01; United States / NEI NIH HHS / EY / 1R01EY015136-01
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
[Publication-country]
England
[Number-of-references]
104
26.
Duan L, Zhang MX:
[Effects of endostatin on the expression of Tubulinbeta mRNA in the retina of oxygen-induced retinal neovascularization].
Sichuan Da Xue Xue Bao Yi Xue Ban
; 2009 Nov;40(6):1008-10, 1020
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[Title]
[Effects of endostatin on the expression of Tubulinbeta mRNA in
the retina
of oxygen-induced
retinal
neovascularization].
OBJECTIVE: To investigate the effect of endostatin on the expression of Tubulinbeta in
the retina
of oxygen-induced
retinal
neovascularization.
In control group, the mice were bred in normal oxygen condition, while the mice in another 2 groups were subjected to hyperoxia condition to establish the oxygen-induced
retinal
neovascularization model.
Total RNA were extracted from
retina of
each mouse in three groups, the quantity of Tubulinbeta mRNA in
retina
was analyzed with quantitative real-time PCR with the special primers.
RESULTS: Quantitativereal-time PCR results indicated that, the expression of Tubulinbeta mRNA in retica was up-regulated in the process of
retinal
neovascularization induced by hyperoxia, and down-regulated by the treatment of ES.
CONCLUSIONS: Endotatin can inhibit the expression of Tubulinbeta mRNA in
retinal
neovascularization, this may be correlated with the inhibitive characteristics of ES on neovascularization.
[MeSH-major]
Endostatins / pharmacology. Hyperoxia / metabolism.
Retina
/ metabolism.
Retinal
Neovascularization / metabolism. Tubulin / metabolism
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(PMID = 20067108.001).
[ISSN]
1672-173X
[Journal-full-title]
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
[ISO-abbreviation]
Sichuan Da Xue Xue Bao Yi Xue Ban
[Language]
chi
[Publication-type]
English Abstract; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
China
[Chemical-registry-number]
0 / Endostatins; 0 / RNA, Messenger; 0 / Tubulin; 0 / beta3 tubulin, mouse
27.
Wolfe AD, Henry JJ:
Neuronal leucine-rich repeat 6 (XlNLRR-6) is required for late lens and retina development in Xenopus laevis.
Dev Dyn
; 2006 Apr;235(4):1027-41
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[Title]
Neuronal leucine-rich repeat 6 (XlNLRR-6) is required for late lens and
retina
development in Xenopus laevis.
Using antisense morpholino oligonucleotide (MO) -mediated knockdown of XlNLRR-6, we demonstrate that this protein is critical for development of the lens,
retina
, and cornea.
Reciprocal transplantation of presumptive lens ectoderm between MO-treated and untreated embryos demonstrate that XlNLRR-6 plays autonomous roles in the development of both the lens and
retina
.
[MeSH-major]
Gene Expression Regulation, Developmental. Lens, Crystalline / embryology. Leucine. Neurons / metabolism.
Retina
/ embryology. Xenopus laevis / embryology
Hazardous Substances Data Bank.
L-Leucine
.
Xenbase.
Xenbase
.
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[Copyright]
(c) 2006 Wiley-Liss, Inc.
(PMID = 16456849.001).
[ISSN]
1058-8388
[Journal-full-title]
Developmental dynamics : an official publication of the American Association of Anatomists
[ISO-abbreviation]
Dev. Dyn.
[Language]
eng
[Grant]
United States / NEI NIH HHS / EY / EY 09844
[Publication-type]
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Oligonucleotides, Antisense; 0 / Xenopus Proteins; GMW67QNF9C / Leucine
28.
Curto GG, Lara JM, Parrilla M, Aijón J, Velasco A:
Modifications of the retina neuronal populations of the heterozygous mutant small eye mouse, the Sey(Dey).
Brain Res
; 2007 Jan 5;1127(1):163-76
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[Title]
Modifications of the
retina
neuronal populations of the heterozygous mutant small eye mouse, the Sey(Dey).
We analyzed the modifications of the
retinal
neurons in a heterozygous mutant small eye mouse, the Sey(Dey).
The partial loss of the genes affected does not prevent the formation of the different layers of the
retina
, but does affect its thickness, principally of the plexiform layers; moreover, the internal limiting membrane is found disorganized.
All the neuronal populations are present in
the retina
of these animals and express the same neurochemical markers as the control animals, but the number of Pax6(+) cells is notably reduced.
These results suggest that, although it does not appear determinant in the differentiation of the distinct neuronal types of the
retina
, the partial lack of genes of the heterozygotes +/Sey(Dey) provokes important morphological and neurochemical modifications in the cytoarchitecture of the
retina
.
[MeSH-major]
Eye Abnormalities / pathology. Eye Proteins / genetics. Gene Expression Regulation, Developmental / genetics. Homeodomain Proteins / genetics. Mutation / genetics. Neurons / pathology. Paired Box Transcription Factors / genetics. Repressor Proteins / genetics.
Retina
/ abnormalities
[MeSH-minor]
Animals. Axons / metabolism. Axons / pathology. Biomarkers / metabolism. Calbindin 2. Calbindins. Calcium-Binding Proteins / genetics. Cell Differentiation / genetics. Dendrites / metabolism. Dendrites / pathology. Disease Models, Animal. Female. Male. Mice. Mice, Neurologic Mutants. Parvalbumins / genetics. Protein Kinase C-alpha / genetics.
Retinal
Ganglion Cells / metabolism.
Retinal
Ganglion Cells / pathology. S100 Calcium Binding Protein G / genetics. Tyrosine 3-Monooxygenase / genetics. WT1 Proteins / genetics
KOMP Repository.
gene/protein/disease-specific - KOMP Repository
(subscription/membership/fee required).
Mouse Genome Informatics (MGI).
Mouse Genome Informatics (MGI)
.
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(PMID = 17113047.001).
[ISSN]
0006-8993
[Journal-full-title]
Brain research
[ISO-abbreviation]
Brain Res.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Netherlands
[Chemical-registry-number]
0 / Biomarkers; 0 / Calbindin 2; 0 / Calbindins; 0 / Calcium-Binding Proteins; 0 / Eye Proteins; 0 / Homeodomain Proteins; 0 / PAX6 protein; 0 / Paired Box Transcription Factors; 0 / Parvalbumins; 0 / Repressor Proteins; 0 / S100 Calcium Binding Protein G; 0 / WT1 Proteins; 148998-28-1 / reticulocalbin; EC 1.14.16.2 / Tyrosine 3-Monooxygenase; EC 2.7.11.13 / Protein Kinase C-alpha
29.
Hasegawa T, McLeod DS, Prow T, Merges C, Grebe R, Lutty GA:
Vascular precursors in developing human retina.
Invest Ophthalmol Vis Sci
; 2008 May;49(5):2178-92
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[Title]
Vascular precursors in developing human
retina
.
PURPOSE: Prior investigation has demonstrated that angioblasts are present in the inner retinas of human embryos and fetuses and that they differentiate and organize to form the primordial
retinal
vasculature.
Coexpression of CD39 (marker for
retinal
angioblasts and endothelial cells) and CXCR4 or c-Kit was investigated by confocal microscopy.
RESULTS: SDF-1 was prominent in inner
retina
with the greatest reaction product near the internal limiting membrane (ILM).
SCF immunoreactivity was also confined to the inner
retina
and increased significantly between 7 and 12 WG.
A layer of CXCR4(+) and c-Kit(+) precursors, some of which coexpressed CD39, existed in the inner
retina
from 7 to 12 WG.
CONCLUSIONS: Embryonic human
retina
has a pool of precursors (CXCR4(+) and c-Kit(+)) that enlarged centrifugally during fetal development.
Both SCF and SDF-1 are associated with the differentiation of
retinal
precursors into angioblasts and their migration to sites of vessel assembly.
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[ErratumIn]
Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2342
(PMID = 18436851.001).
[ISSN]
0146-0404
[Journal-full-title]
Investigative ophthalmology & visual science
[ISO-abbreviation]
Invest. Ophthalmol. Vis. Sci.
[Language]
ENG
[Grant]
United States / NEI NIH HHS / EY / EY 01765; United States / NEI NIH HHS / EY / P30 EY001765; United States / NEI NIH HHS / EY / EY 09357; United States / NEI NIH HHS / EY / R01 EY009357; United States / NEI NIH HHS / EY / R01 EY009357-16
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Antigens, CD; 0 / CXCR4 protein, human; 0 / Chemokine CXCL12; 0 / Receptors, CXCR4; 0 / Stem Cell Factor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 3.6.1.5 / Apyrase; EC 3.6.1.5 / CD39 antigen
[Other-IDs]
NLM/ NIHMS215629; NLM/ PMC4943084
30.
Weber AJ, Harman CD:
BDNF preserves the dendritic morphology of alpha and beta ganglion cells in the cat retina after optic nerve injury.
Invest Ophthalmol Vis Sci
; 2008 Jun;49(6):2456-63
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[Title]
BDNF preserves the dendritic morphology of alpha and beta ganglion cells in the cat
retina
after optic nerve injury.
PURPOSE: To examine whether brain-derived neurotrophic factor (BDNF), a potent neuroprotectant in the mammalian
retina
, also plays a role in preserving the dendritic integrity of the surviving ganglion cells after optic nerve injury.
[MeSH-major]
Brain-Derived Neurotrophic Factor / pharmacology. Dendrites / drug effects. Neuroprotective Agents / pharmacology. Optic Nerve Injuries / drug therapy.
Retinal
Ganglion Cells / drug effects
[MeSH-minor]
Animals. Cats. Cell Count. Cell Survival / drug effects. Recombinant Proteins / pharmacology.
Retinal
Degeneration / etiology.
Retinal
Degeneration / prevention & control
MedlinePlus Health Information.
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(PMID = 18263808.001).
[ISSN]
0146-0404
[Journal-full-title]
Investigative ophthalmology & visual science
[ISO-abbreviation]
Invest. Ophthalmol. Vis. Sci.
[Language]
eng
[Grant]
United States / NEI NIH HHS / EY / EY11159
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
United States
[Chemical-registry-number]
0 / Brain-Derived Neurotrophic Factor; 0 / Neuroprotective Agents; 0 / Recombinant Proteins
31.
Natoli R, Provis J, Valter K, Stone J:
Expression and role of the early-response gene Oxr1 in the hyperoxia-challenged mouse retina.
Invest Ophthalmol Vis Sci
; 2008 Oct;49(10):4561-7
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[Title]
Expression and role of the early-response gene Oxr1 in the hyperoxia-challenged mouse
retina
.
PURPOSE: To examine the response of mouse
retina
to sustained hyperoxia.
RESULTS: In the C57BL/6J
retina
, Oxr1 was upregulated at 3 days of exposure, matching the early period of resistance to hyperoxia in this strain, and fell below control levels at 14 days, when photoreceptor degeneration had begun.
The
retinal
response to hyperoxia may constitute acute and chronic phases in which photoreceptors are first resistant, and then vulnerable, to oxidative damage.
Understanding this biphasic response may be important in understanding the role of oxygen in the progress of
retinal
dystrophy.
[MeSH-major]
Gene Expression Regulation / physiology. Hyperoxia / genetics. Nuclear Proteins / genetics. Oxidative Stress. Oxygen / toxicity. Photoreceptor Cells, Vertebrate / metabolism.
Retinal
Degeneration / genetics
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(PMID = 18539939.001).
[ISSN]
1552-5783
[Journal-full-title]
Investigative ophthalmology & visual science
[ISO-abbreviation]
Invest. Ophthalmol. Vis. Sci.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Glial Fibrillary Acidic Protein; 0 / Mitochondrial Proteins; 0 / Nuclear Proteins; 0 / Oxr1 protein, mouse; 0 / RNA, Messenger; S88TT14065 / Oxygen
32.
Haynes T, Gutierrez C, Aycinena JC, Tsonis PA, Del Rio-Tsonis K:
BMP signaling mediates stem/progenitor cell-induced retina regeneration.
Proc Natl Acad Sci U S A
; 2007 Dec 18;104(51):20380-5
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[Title]
BMP signaling mediates stem/progenitor cell-induced
retina
regeneration.
We identified a mechanism whereby
retina
regeneration in the embryonic chick can be induced by the contribution of stem/progenitor cells.
We show that bone morphogenetic protein (BMP) signaling is sufficient and necessary to induce
retina
regeneration and that its action can be divided into two phases.
These results unravel a mechanism for stem/progenitor cell-mediated
retina
regeneration, where BMP activation establishes a cross-talk with the FGF pathway and selectively activates the canonical and noncanonical BMP pathways.
Retina
stem/progenitor cells exist in other species, including humans.
Thus, our findings provide insights on how
retinal
stem cells can be activated for possible regenerative therapies.
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Curr Neurovasc Res. 2004 Jul;1(3):231-9
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16181073.001
]
[Cites]
J Comp Neurol. 2006 Mar 20;495(3):263-78
[
16440295.001
]
[Cites]
J Comp Neurol. 2001 Feb 19;430(4):562-72
[
11169487.001
]
(PMID = 18093961.001).
[ISSN]
1091-6490
[Journal-full-title]
Proceedings of the National Academy of Sciences of the United States of America
[ISO-abbreviation]
Proc. Natl. Acad. Sci. U.S.A.
[Language]
ENG
[Grant]
United States / NIA NIH HHS / AG / R21 AG024937-02; United States / NIA NIH HHS / AG / R21 AG 024937-01; United States / NIA NIH HHS / AG / AG024937-02; United States / NEI NIH HHS / EY / EY10540; United States / NEI NIH HHS / EY / R01 EY010540; United States / NIA NIH HHS / AG / R21 AG024937
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
United States
[Chemical-registry-number]
0 / Bone Morphogenetic Proteins; 0 / Smad Proteins; 62031-54-3 / Fibroblast Growth Factors; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases
[Other-IDs]
NLM/ PMC2154439
33.
Subramanian P, Notario PM, Becerra SP:
Pigment epithelium-derived factor receptor (PEDF-R): a plasma membrane-linked phospholipase with PEDF binding affinity.
Adv Exp Med Biol
; 2010;664:29-37
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Pigment epithelium-derived factor (PEDF), a multifunctional protein, acts in
retinal
differentiation, survival and maintenance by interacting with high affinity receptors on the surface of target cells.
This newly identified protein is present on the surface
of retina
and RPE cells, and has the expected transmembrane topology.
In summary, PEDF-R is a novel component of the
retina
that is a phospholipase-linked membrane protein with high affinity for PEDF.
[MeSH-minor]
Computational Biology. Humans. Ligands. Protein Binding. Protein Transport.
Retina
/ cytology.
Retina
/ enzymology. Subcellular Fractions / enzymology
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[ISSN]
0065-2598
[Journal-full-title]
Advances in experimental medicine and biology
[ISO-abbreviation]
Adv. Exp. Med. Biol.
[Language]
eng
[Grant]
United States / Intramural NIH HHS / / Z01 EY000306-13
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Eye Proteins; 0 / Ligands; 0 / Nerve Growth Factors; 0 / Receptors, Neuropeptide; 0 / Serpins; 0 / pigment epithelium-derived factor; 0 / pigment epithelium-derived factor receptor; EC 3.1.- / Phospholipases
[Other-IDs]
NLM/ NIHMS544292; NLM/ PMC3901638
34.
Katyal S, Gao Z, Monckton E, Glubrecht D, Godbout R:
Hierarchical disabled-1 tyrosine phosphorylation in Src family kinase activation and neurite formation.
J Mol Biol
; 2007 Apr 27;368(2):349-64
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There are two developmentally regulated alternatively spliced forms of Disabled-1 (Dab1) in the chick
retina
: an early form (Dab1-E) expressed in
retinal
precursor cells and a late form (Dab1-L) expressed in neuronal cells.
Here, we use Reelin-expressing primary
retinal
cultures to investigate the role of the four Dab1 tyrosine phosphorylation sites on overall tyrosine phosphorylation, Dab1 phosphorylation, SFK activation and neurite formation.
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[ISSN]
0022-2836
[Journal-full-title]
Journal of molecular biology
[ISO-abbreviation]
J. Mol. Biol.
[Language]
ENG
[Grant]
None / None / / 82789-1; Canada / Canadian Institutes of Health Research / / 82789-1
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Antibodies; 0 / Avian Proteins; 0 / Cell Adhesion Molecules, Neuronal; 0 / Extracellular Matrix Proteins; 0 / Nerve Tissue Proteins; 0 / Protein Isoforms; 0 / Receptors, LDL; 0 / Recombinant Fusion Proteins; 0 / VLDL receptor; 147336-22-9 / Green Fluorescent Proteins; 21820-51-9 / Phosphotyrosine; EC 2.7.10.2 / src-Family Kinases; EC 3.4.21.- / Serine Endopeptidases; EC 3.4.21.- / reelin protein
[Other-IDs]
NLM/ CAMS3217; NLM/ PMC4071145
35.
Oh EC, Khan N, Novelli E, Khanna H, Strettoi E, Swaroop A:
Transformation of cone precursors to functional rod photoreceptors by bZIP transcription factor NRL.
Proc Natl Acad Sci U S A
; 2007 Jan 30;104(5):1679-84
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Networks of transcriptional regulatory proteins dictate specification of neural lineages from multipotent
retinal
progenitors.
To examine the role of NRL in cell fate determination, we generated transgenic mice that express Nrl under the control of Crx promoter in postmitotic photoreceptor precursors of WT and Nrl-/-
retina
.
We show that NRL expression, in both genetic backgrounds, leads to a functional
retina
with only rod photoreceptors.
The absence of cones does not alter
retinal
lamination, although cone synaptic circuitry is now recruited by rods.
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.
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(PMID = 17242361.001).
[ISSN]
0027-8424
[Journal-full-title]
Proceedings of the National Academy of Sciences of the United States of America
[ISO-abbreviation]
Proc. Natl. Acad. Sci. U.S.A.
[Language]
ENG
[Grant]
United States / NEI NIH HHS / EY / EY007003; United States / NEI NIH HHS / EY / R01 EY012654; United States / NEI NIH HHS / EY / R01 EY011115; United States / NIDDK NIH HHS / DK / P60 DK020572; United States / NEI NIH HHS / EY / EY012654; United States / NEI NIH HHS / EY / EY011115; United States / NIDDK NIH HHS / DK / 5P60 DK20572; United States / NEI NIH HHS / EY / P30 EY007003; United States / NEI NIH HHS / EY / F31 EY007003
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Basic-Leucine Zipper Transcription Factors; 0 / Eye Proteins; 0 / Nrl protein, mouse
[Other-IDs]
NLM/ PMC1780067
36.
Majumdar S, Wässle H, Jusuf PR, Haverkamp S:
Mirror-symmetrical populations of wide-field amacrine cells of the macaque monkey retina.
J Comp Neurol
; 2008 May 1;508(1):13-27
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[Title]
Mirror-symmetrical populations of wide-field amacrine cells of the macaque monkey
retina
.
The density of the cells increased from approximately 70/mm(2) in the peripheral
retina
to approximately 700/mm(2) in the central
retina
.
The close proximity of the dendritic strata of glypho-immunoreactive amacrine cells, cholinergic amacrine cells, and direction-selective ganglion cells suggests a possible role of the cells in the generation of direction-selective light responses of the monkey
retina
.
[MeSH-major]
Amacrine Cells. Macaca fascicularis / anatomy & histology.
Retina
/ cytology
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[Copyright]
(c) 2008 Wiley-Liss, Inc.
(PMID = 18288700.001).
[ISSN]
1096-9861
[Journal-full-title]
The Journal of comparative neurology
[ISO-abbreviation]
J. Comp. Neurol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Amino Acids; 0 / dolaisoleucine; 56-12-2 / gamma-Aminobutyric Acid; EC 2.3.1.6 / Choline O-Acetyltransferase; EC 2.4.1.- / Glycogen Phosphorylase
37.
Katsumata O, Ohara N, Tamaki H, Niimura T, Naganuma H, Watanabe M, Sakagami H:
IQ-ArfGEF/BRAG1 is associated with synaptic ribbons in the mouse retina.
Eur J Neurosci
; 2009 Oct;30(8):1509-16
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[Title]
IQ-ArfGEF/BRAG1 is associated with synaptic ribbons in the mouse
retina
.
In this study, we examined the immunohistochemical localization of IQ-ArfGEF/BRAG1 in the adult mouse
retina
using light and electron microscopy.
Furthermore, immunoprecipitation analysis showed that anti-IQ-ArfGEF/BRAG1 antibody efficiently pulled down RIBEYE from
retinal
lysates.
These findings indicate that IQ-ArfGEF/BRAG1 is a novel component of
retinal
synaptic ribbons and forms a protein complex with RIBEYE.
[MeSH-major]
Guanine Nucleotide Exchange Factors / metabolism. Nerve Tissue Proteins / metabolism.
Retina
/ cytology. Synapses / metabolism. Synapses / ultrastructure
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(PMID = 19811534.001).
[ISSN]
1460-9568
[Journal-full-title]
The European journal of neuroscience
[ISO-abbreviation]
Eur. J. Neurosci.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
France
[Chemical-registry-number]
0 / Ctbp2 protein, mouse; 0 / DNA-Binding Proteins; 0 / Guanine Nucleotide Exchange Factors; 0 / IQSEC2 protein, mouse; 0 / Intracellular Signaling Peptides and Proteins; 0 / Membrane Proteins; 0 / Nerve Tissue Proteins; 0 / Phosphoproteins; 0 / RNA, Messenger; EC 2.7.4.8 / Dlgh4 protein, mouse; EC 2.7.4.8 / Guanylate Kinase
38.
Rothermel A, Weigel W, Pfeiffer-Guglielmi B, Hamprecht B, Robitzki AA:
Immunocytochemical analysis of glycogen phosphorylase isozymes in the developing and adult retina of the domestic chicken (Gallus domesticus).
Neurochem Res
; 2008 Feb;33(2):336-47
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[Title]
Immunocytochemical analysis of glycogen phosphorylase isozymes in the developing and adult
retina of
the domestic chicken (Gallus domesticus).
Glycogen is the major energy reserve in neural tissues including
the retina
.
By applying isozyme-specific antibodies it could be demonstrated that the GP BB (brain), but not the GP MM (muscle) isoform is expressed in the chicken
retina
in neuronal and glial (Müller) cells.
In the embryonic chicken
retina
, GP showed a development-dependent expression pattern.
Double-labeling experiments with cell type-specific antibodies revealed that GP is expressed in various layers of the
retina
some of which, e.g., the photoreceptor inner segments, are known to be sites of high energy consumption.
[MeSH-major]
Glycogen Phosphorylase / metabolism. Isoenzymes / metabolism.
Retina
/ enzymology
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(PMID = 17940897.001).
[ISSN]
0364-3190
[Journal-full-title]
Neurochemical research
[ISO-abbreviation]
Neurochem. Res.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Isoenzymes; EC 2.4.1.- / Glycogen Phosphorylase
39.
Zacks DN, Boehlke C, Richards AL, Zheng QD:
Role of the Fas-signaling pathway in photoreceptor neuroprotection.
Arch Ophthalmol
; 2007 Oct;125(10):1389-95
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OBJECTIVE: To determine whether inhibiting the Fas proapoptosis pathway will result in increased photoreceptor survival after separation of the
retina
from the
retinal
pigment epithelium (RPE).
METHODS:
Retina
/RPE separation was induced in rat and mouse eyes by the subretinal injection of hyaluronic acid, 1%.
Indices of photoreceptor death included terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) staining, cell counts, and
retinal
thickness measurements.
RESULTS: Inhibition of Fas signaling using Fas receptor-neutralizing antibody, siFas, or LPR mice resulted in a significant reduction in the number of TUNEL-positive photoreceptor cells as well as in a significant preservation of outer nuclear layer cell counts and thickness as compared with
retina
/RPE separation in eyes with intact Fas signaling.
CONCLUSIONS: Inhibition of the Fas proapoptosis pathway results in significant photoreceptor preservation after
retinal
separation from the RPE.
CLINICAL RELEVANCE: Fas-pathway inhibition might serve as a novel mechanism for preserving photoreceptor cells during
retinal
disease.
[MeSH-minor]
Animals. Antibodies, Blocking / pharmacology. Apoptosis / drug effects. Cell Count. Cell Survival / physiology. Fluorescent Antibody Technique, Indirect. Immunoblotting. In Situ Nick-End Labeling. Mice. Mice, Inbred C57BL. Mice, Inbred MRL lpr. RNA / isolation & purification. RNA, Small Interfering / pharmacology. Rats. Rats, Inbred BN.
Retinal
Detachment / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Rhodopsin / metabolism. Rod Opsins / metabolism
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(PMID = 17923548.001).
[ISSN]
0003-9950
[Journal-full-title]
Archives of ophthalmology (Chicago, Ill. : 1960)
[ISO-abbreviation]
Arch. Ophthalmol.
[Language]
eng
[Grant]
United States / NEI NIH HHS / EY / K08-EY-14705
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
United States
[Chemical-registry-number]
0 / Antibodies, Blocking; 0 / Antigens, CD95; 0 / Fas protein, mouse; 0 / RNA, Small Interfering; 0 / Rod Opsins; 0 / Tnfrsf6 protein, rat; 63231-63-0 / RNA; 9009-81-8 / Rhodopsin
40.
Kralj-Hans I, Tibber M, Jeffery G, Mobbs P:
Differential effect of dopamine on mitosis in early postnatal albino and pigmented rat retinae.
J Neurobiol
; 2006 Jan;66(1):47-55
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Insufficient levels of L-DOPA, released from the
retinal
pigment epithelium (RPE), in albino animals are considered responsible for the abnormal development of the underlying neural
retina
.
L-DOPA normalizes
retinal
neurogenesis by reducing levels of cell proliferation either by acting on the cells directly or by being converted into dopamine.
Thus, the differential effects of dopamine on neural retinae from pigmented and albino rats in vitro must result from the activation of D1 receptors, which are present in
the retina
from birth.
These findings are discussed in light of previous reports of reduced catecholamine levels in the albino
retina
.
[MeSH-major]
Dopamine / pharmacology. Mitosis / drug effects. Neurons / drug effects.
Retina
/ cytology
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DOPAMINE
.
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(PMID = 16187306.001).
[ISSN]
0022-3034
[Journal-full-title]
Journal of neurobiology
[ISO-abbreviation]
J. Neurobiol.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Benzazepines; 0 / Dopamine Antagonists; 0 / Receptors, Dopamine D1; EC 4.1.1.28 / Aromatic-L-Amino-Acid Decarboxylases; VTD58H1Z2X / Dopamine
41.
Nakamura H, Hayakawa K, Sawaguchi S, Gaja T:
Removal of retinal indocyanine green dye by autologous serum irrigation in macular hole surgery.
Retina
; 2005 Sep;25(6):736-41
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[Title]
Removal of
retinal
indocyanine green dye by autologous serum irrigation in macular hole surgery.
PURPOSE: To investigate the efficacy of autologous serum irrigation for removal of
retinal
indocyanine green (ICG) dye used to visualize the internal limiting membrane (ILM) in macular hole surgery.
Nine of 18 eyes underwent intravitreal autologous serum irrigation before completion of the surgery to remove residual ICG dye in
the retina
.
The main outcome measures were postoperative visual acuity, macular hole status,
retinal
pigment epithelial changes, and time course of ICG dye fading from
the retina
with or without intravitreal autologous serum irrigation.
ICG dye disappeared from
the retina
within an average of 6.1 months after surgery without serum and 2.4 months after surgery with serum (P < 0.01).
The application was simple and safe and significantly shortened the period of residual
retinal
ICG staining.
[MeSH-major]
Coloring Agents / metabolism. Indocyanine Green / metabolism.
Retina
/ metabolism.
Retinal
Perforations / surgery. Serum. Therapeutic Irrigation / methods
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INDOCYANINE GREEN
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(PMID = 16141861.001).
[ISSN]
0275-004X
[Journal-full-title]
Retina (Philadelphia, Pa.)
[ISO-abbreviation]
Retina (Philadelphia, Pa.)
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Coloring Agents; IX6J1063HV / Indocyanine Green
42.
Koinzer S, Elsner H, Klatt C, Pörksen E, Brinkmann R, Birngruber R, Roider J:
Selective retina therapy (SRT) of chronic subfoveal fluid after surgery of rhegmatogenous retinal detachment: three case reports.
Graefes Arch Clin Exp Ophthalmol
; 2008 Oct;246(10):1373-8
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[Title]
Selective
retina
therapy (SRT) of chronic subfoveal fluid after surgery of rhegmatogenous
retinal
detachment: three case reports.
BACKGROUND: Shallow subfoveal fluid accumulation after successful surgery for
retinal
detachment can be the reason for compromised visual acuity.
Selective
retina
therapy (SRT) is a new laser technology that uses a train of mus-laser pulses to selectively damage
retinal
pigment epithelial (RPE) cells while sparing
retinal
structures.
METHODS: We treated three patients with chronic subfoveal fluid accumulation after
retinal
detachment surgery.
The median period between
retinal
surgery and SRT treatment was 7 months.
In this situation where no other therapeutical options are established, SRT may be a beneficial treatment for chronic subfoveal fluid accumulation after
retinal
detachment surgery.
[MeSH-major]
Body Fluids / metabolism. Lasers, Solid-State / therapeutic use. Low-Level Light Therapy / methods. Postoperative Complications.
Retinal
Detachment / surgery.
Retinal
Pigment Epithelium / surgery
MedlinePlus Health Information.
consumer health - After Surgery
.
MedlinePlus Health Information.
consumer health - Retinal Detachment
.
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[Cites]
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Eye (Lond). 2007 Sep;21(9):1174-8
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16710430.001
]
(PMID = 18546010.001).
[ISSN]
0721-832X
[Journal-full-title]
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
[ISO-abbreviation]
Graefes Arch. Clin. Exp. Ophthalmol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Germany
43.
Lee EJ, Gibo TL, Grzywacz NM:
Dark-rearing-induced reduction of GABA and GAD and prevention of the effect by BDNF in the mouse retina.
Eur J Neurosci
; 2006 Oct;24(8):2118-34
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[Title]
Dark-rearing-induced reduction of GABA and GAD and prevention of the effect by BDNF in the mouse
retina
.
Gamma-aminobutyric acid (GABA) is an important
retinal
neurotransmitter.
Second, can
the retina
recover from the effects of dark-rearing if returned to a normal light-dark cycle?
[MeSH-major]
Brain-Derived Neurotrophic Factor / pharmacology. Glutamate Decarboxylase / biosynthesis. Isoenzymes / biosynthesis.
Retina
/ drug effects. gamma-Aminobutyric Acid / biosynthesis
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HEMATOXYLIN
.
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(PMID = 17074038.001).
[ISSN]
0953-816X
[Journal-full-title]
The European journal of neuroscience
[ISO-abbreviation]
Eur. J. Neurosci.
[Language]
eng
[Grant]
United States / NEI NIH HHS / EY / EY08921; United States / NEI NIH HHS / EY / EY11170
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
France
[Chemical-registry-number]
0 / Brain-Derived Neurotrophic Factor; 0 / Coloring Agents; 0 / Isoenzymes; 56-12-2 / gamma-Aminobutyric Acid; EC 4.1.1.15 / Glutamate Decarboxylase; EC 4.1.1.15 / glutamate decarboxylase 2; YKM8PY2Z55 / Hematoxylin
44.
Kay JN, Link BA, Baier H:
Staggered cell-intrinsic timing of ath5 expression underlies the wave of ganglion cell neurogenesis in the zebrafish retina.
Development
; 2005 Jun;132(11):2573-85
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[Title]
Staggered cell-intrinsic timing of ath5 expression underlies the wave of ganglion cell neurogenesis in the zebrafish
retina
.
In the vertebrate
retina
, initiation of neurogenesis has recently been explained by a 'sequential-induction' model--signals from newly differentiated neurons are thought to trigger neurogenesis in adjacent progenitors, creating a wave of neurogenesis that spreads across
the retina
in a stereotypical manner.
We show here, however, that the wave of neurogenesis in the zebrafish
retina
can emerge through the independent action of progenitor cells--progenitors in different parts of the
retina
appear pre-specified to initiate neurogenesis at different times.
[MeSH-major]
Cell Differentiation / physiology. DNA-Binding Proteins / metabolism. Ganglia, Sensory / embryology. Gene Expression Regulation, Developmental. Growth Substances / metabolism.
Retinal
Ganglion Cells / physiology. Zebrafish / embryology. Zebrafish Proteins / metabolism
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CYCLOPAMINE
.
ZFIN.
ZFIN
.
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(PMID = 15857917.001).
[ISSN]
0950-1991
[Journal-full-title]
Development (Cambridge, England)
[ISO-abbreviation]
Development
[Language]
eng
[Grant]
United States / NEI NIH HHS / EY / EY014167; United States / NEI NIH HHS / EY / EY13855
[Publication-type]
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
[Publication-country]
England
[Chemical-registry-number]
0 / DNA Primers; 0 / DNA-Binding Proteins; 0 / Growth Substances; 0 / Hedgehog Proteins; 0 / Trans-Activators; 0 / Veratrum Alkaloids; 0 / Zebrafish Proteins; 0 / ath5 protein, zebrafish; ZH658AJ192 / cyclopamine
45.
Calamusa M, Pattabiraman PP, Pozdeyev N, Iuvone PM, Cellerino A, Domenici L:
Specific alterations of tyrosine hydroxylase immunopositive cells in the retina of NT-4 knock out mice.
Vision Res
; 2007 May;47(11):1523-36
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[Title]
Specific alterations of tyrosine hydroxylase immunopositive cells in
the retina
of NT-4 knock out mice.
To assess the effect of NT-4 deprivation on maturation of
retinal
circuitry, we investigated a mouse with targeted deletion of the gene encoding nt-4 (nt-4(-/-)).
In particular, we studied neurons immunostained by an antibody recognizing tyrosine hydroxylase (TH), the rate limiting enzyme for dopamine (
DA
) synthesis.
We found that TH immunopositive processes were altered in
the retina
of nt-4(-/-).
Alteration of TH immunopositive processes in nt-4(-/-) mice resulted in changes of
DA
turnover, as assessed by high-pressure liquid chromatography measurements.
These findings suggest that
retinal
NT-4 plays a role in the morphological maturation of dopaminergic
retinal
cells.
Hazardous Substances Data Bank.
DOPAMINE
.
KOMP Repository.
gene/protein/disease-specific - KOMP Repository
(subscription/membership/fee required).
Mouse Genome Informatics (MGI).
Mouse Genome Informatics (MGI)
.
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(PMID = 17350071.001).
[ISSN]
0042-6989
[Journal-full-title]
Vision research
[ISO-abbreviation]
Vision Res.
[Language]
ENG
[Grant]
United States / NEI NIH HHS / EY / P30 EY006360; United States / NEI NIH HHS / EY / R01 EY004864; United States / NEI NIH HHS / EY / EY004864; United States / NEI NIH HHS / EY / EY014764
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Brain-Derived Neurotrophic Factor; 0 / Nerve Growth Factors; 0 / RNA, Messenger; 143551-63-7 / neurotrophin 4; EC 1.14.16.2 / Tyrosine 3-Monooxygenase; VTD58H1Z2X / Dopamine
46.
Cottaris NP, Elfar SD:
How the retinal network reacts to epiretinal stimulation to form the prosthetic visual input to the cortex.
J Neural Eng
; 2005 Mar;2(1):S74-90
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[Title]
How the
retinal
network reacts to epiretinal stimulation to form the prosthetic visual input to the cortex.
We considered the problem of determining how the
retinal
network may interact with electrical epiretinal stimulation in shaping the spike trains of ON and OFF ganglion cells, and thus the synaptic input to first-stage cortical neurons.
To do so, we developed a biophysical model of the
retinal
network with nine stacked neuronal mosaics.
Here, we describe the model's behavior under (i) electrical stimulation of a
retina
with complete cone photoreceptor loss, but an otherwise intact circuitry and (ii) electrical stimulation of a fully-functional
retina
.
Activation of the
retinal
network biases the excitation of ON relative to OFF ganglion cells, and in addition, gradually interpolates and focuses the initial, patchy synaptic input to the cortex.
These findings occur in both the normal and the degenerated
retina
simulations, but the normal
retina
exhibits a tighter spatiotemporal response.
[MeSH-minor]
Animals. Computer Simulation. Humans. Photic Stimulation / methods. Prostheses and Implants.
Retinal
Degeneration / physiopathology.
Retinal
Ganglion Cells / physiology
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(PMID = 15876658.001).
[ISSN]
1741-2560
[Journal-full-title]
Journal of neural engineering
[ISO-abbreviation]
J Neural Eng
[Language]
eng
[Publication-type]
Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies
[Publication-country]
England
47.
Nakazawa T, Matsubara A, Noda K, Hisatomi T, She H, Skondra D, Miyahara S, Sobrin L, Thomas KL, Chen DF, Grosskreutz CL, Hafezi-Moghadam A, Miller JW:
Characterization of cytokine responses to retinal detachment in rats.
Mol Vis
; 2006;12:867-78
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[Title]
Characterization of cytokine responses to
retinal
detachment in rats.
PURPOSE: Photoreceptor apoptosis is associated with
retinal
detachment (RD) induced photoreceptor degeneration.
Retinal
tissues were collected at various times (1, 3, 6, 24, and 72 h) after the induction of detachment.
To identify the cellular sources of the expressed genes, cells from various layers of the
retina
were obtained using laser capture microdissection (LCM), and their mRNAs were isolated.
RESULTS: At 72 h after RD a significant increase in mRNA levels for
tumor
necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), monocyte chemotactic protein-1 (MCP-1), and basic fibroblast growth factor (bFGF) were detected in the neural
retina
.
LCM revealed increased expression of mRNA for bFGF and MCP-1 in all
retinal
layers, though bFGF was especially evident in the outer nuclear layer (ONL) and MCP-1 in the inner nuclear layer (INL).
Immunohistochemistry showed TNF-alpha and bFGF expression in the whole
retina
, with IL-1beta specifically expressed in astrocytes and MCP-1 in Müller cells.
CONCLUSIONS:
Retinal
glial cells, including astrocytes and Müller cells, are a major source of cytokine induction after RD.
[MeSH-major]
Chemokine CCL2 / metabolism. Fibroblast Growth Factor 2 / metabolism. Interleukin-1 / metabolism.
Retinal
Detachment / metabolism.
Tumor
Necrosis Factor-alpha / metabolism
[MeSH-minor]
Animals. Apoptosis. Astrocytes / metabolism. Enzyme-Linked Immunosorbent Assay. Immunohistochemistry. Male. Neuroglia / metabolism. Photoreceptor Cells, Vertebrate. RNA, Messenger / metabolism. Rats. Rats, Inbred BN.
Retina
/ metabolism.
Retina
/ pathology.
Retinal
Ganglion Cells / metabolism. Tissue Distribution
MedlinePlus Health Information.
consumer health - Retinal Detachment
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
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NCI CPTC Antibody Characterization Program.
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(PMID = 16917487.001).
[ISSN]
1090-0535
[Journal-full-title]
Molecular vision
[ISO-abbreviation]
Mol. Vis.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Ccl2 protein, rat; 0 / Chemokine CCL2; 0 / Interleukin-1; 0 / RNA, Messenger; 0 / Tumor Necrosis Factor-alpha; 103107-01-3 / Fibroblast Growth Factor 2
48.
Rajala RV:
Phosphoinositide 3-kinase signaling in the vertebrate retina.
J Lipid Res
; 2010 Jan;51(1):4-22
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[Title]
Phosphoinositide 3-kinase signaling in the vertebrate
retina
.
Studies from our laboratory have shown that
the retina
and rod outer segments (ROSs) have active PI metabolism.
This article describes recent studies on the PI3K-generated PI lipid second messengers in the control and regulation of PI-binding proteins in the vertebrate
retina
.
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[ISSN]
1539-7262
[Journal-full-title]
Journal of lipid research
[ISO-abbreviation]
J. Lipid Res.
[Language]
ENG
[Grant]
United States / NCRR NIH HHS / RR / P20 RR017703; United States / NEI NIH HHS / EY / P30 EY012190; United States / NEI NIH HHS / EY / EY12190; United States / NEI NIH HHS / EY / R01 EY000871; United States / NCRR NIH HHS / RR / P20-RR17703; United States / NEI NIH HHS / EY / EY016507; United States / NEI NIH HHS / EY / EY00871; United States / NEI NIH HHS / EY / R01 EY016507
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Review
[Publication-country]
United States
[Chemical-registry-number]
0 / Phosphatidylinositols; 0 / Protein Subunits; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 3.1.3.48 / Protein Tyrosine Phosphatases
[Number-of-references]
291
[Other-IDs]
NLM/ PMC2789784
49.
Kram YA, Mantey S, Corbo JC:
Avian cone photoreceptors tile the retina as five independent, self-organizing mosaics.
PLoS One
; 2010 Feb 01;5(2):e8992
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[Title]
Avian cone photoreceptors tile
the retina
as five independent, self-organizing mosaics.
The avian
retina
possesses one of the most sophisticated cone photoreceptor systems among vertebrates.
Here we show that the five cone types of the chicken independently tile
the retina
as highly ordered mosaics with a characteristic spacing between cones of the same type.
Since regular photoreceptor spacing is critical for uniform sampling of visual space, the cone mosaics of the avian
retina
represent an elegant example of the emergence of adaptive global patterning secondary to simple local interactions between individual photoreceptors.
Our results indicate that the evolutionary pressures that gave rise to the avian
retina
's various adaptations for enhanced color discrimination also acted to fine-tune its spatial sampling of color and luminance.
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1932-6203
[Journal-full-title]
PloS one
[ISO-abbreviation]
PLoS ONE
[Language]
ENG
[Grant]
United States / NEI NIH HHS / EY / R01 EY018826; United States / NEI NIH HHS / EY / R01EY018826; United States / Howard Hughes Medical Institute / /
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Oils; 0 / Retinal Pigments
[Other-IDs]
NLM/ PMC2813877
50.
Tucker BA, Redenti SM, Jiang C, Swift JS, Klassen HJ, Smith ME, Wnek GE, Young MJ:
The use of progenitor cell/biodegradable MMP2-PLGA polymer constructs to enhance cellular integration and retinal repopulation.
Biomaterials
; 2010 Jan;31(1):9-19
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[Title]
The use of progenitor cell/biodegradable MMP2-PLGA polymer constructs to enhance cellular integration and
retinal
repopulation.
The inability of the adult mammalian
retina
to regenerate can be partly attributed to the expression of injury-induced inhibitory extracellular matrix (ECM) and cell adhesion molecules.
In particular, photoreceptor degeneration stimulates deposition of the inhibitory ECM proteins neurocan and CD44 at the outer limits of the dystrophic
retina
, where they act as a barrier against cellular migration and axonal extension.
We have previously shown that degradation of these molecules, via induction of MMP2, promotes host-donor integration and
retinal
repopulation following transplantation.
Here we present a biodegradable/biocompatible polymer scaffold that has the ability to deliver MMP2, in conjunction with
retinal
progenitor cells, directly to the site of
retinal
injury in an attempt to enhance cellular integration and promote
retinal
repopulation.
Following delivery, significant degradation of CD44 and neurocan from the outer limits of the dystrophic
retina
, without further disruption of
retinal
architecture, was observed.
As a result, the number of
retinal
progenitor cells that migrated beyond the glial barrier into the degenerating host increased significantly.
These cells took up residence in the
retinal
outer nuclear layer, adopted appropriate photoreceptor morphology and expressed the mature photoreceptor markers recoverin and rhodopsin.
Thus, we have created a cell delivery platform that upon transplantation provides controlled release of active-MMP2 directly to the site of
retinal
injury, stimulating inhibitory ECM barrier removal and enhancement of stem cell integration and
retinal
repopulation.
[MeSH-major]
Lactic Acid / metabolism. Matrix Metalloproteinase 2 / metabolism. Polyglycolic Acid / metabolism.
Retina
/ metabolism. Stem Cells / cytology
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(PMID = 19775744.001).
[ISSN]
1878-5905
[Journal-full-title]
Biomaterials
[ISO-abbreviation]
Biomaterials
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
[Publication-country]
England
[Chemical-registry-number]
0 / polylactic acid-polyglycolic acid copolymer; 26009-03-0 / Polyglycolic Acid; 33X04XA5AT / Lactic Acid; EC 3.4.24.24 / Matrix Metalloproteinase 2
51.
Garcia-Frigola C, Carreres MI, Vegar C, Herrera E:
Gene delivery into mouse retinal ganglion cells by in utero electroporation.
BMC Dev Biol
; 2007;7:103
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[Title]
Gene delivery into mouse
retinal
ganglion cells by in utero electroporation.
BACKGROUND: The neural
retina
is a highly structured tissue of the central nervous system that is formed by seven different cell types that are arranged in layers.
Despite much effort, the genetic mechanisms that underlie
retinal
development are still poorly understood.
In recent years, large-scale genomic analyses have identified candidate genes that may play a role in
retinal
neurogenesis, axon guidance and other key processes during the development of the visual system.
Gene delivery techniques have been described to express exogenous proteins in
the retina
of newborn mice but these approaches do not efficiently introduce genes into the only
retinal
cell type that transmits visual information to the brain, the
retinal
ganglion cells (RGCs).
[MeSH-major]
Gene Expression Regulation, Developmental. Gene Transfer Techniques.
Retinal
Ganglion Cells
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[ISSN]
1471-213X
[Journal-full-title]
BMC developmental biology
[ISO-abbreviation]
BMC Dev. Biol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Other-IDs]
NLM/ PMC2080638
52.
Hauck SM, Kinkl N, Deeg CA, Swiatek-de Lange M, Schöffmann S, Ueffing M:
GDNF family ligands trigger indirect neuroprotective signaling in retinal glial cells.
Mol Cell Biol
; 2006 Apr;26(7):2746-57
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[Title]
GDNF family ligands trigger indirect neuroprotective signaling in
retinal
glial cells.
Apoptotic cell death of photoreceptors is the final event leading to blindness in the heterogeneous group of inherited
retinal
degenerations.
GDNF (glial cell-line-derived neurotrophic factor) was found to rescue photoreceptor function and survival very effectively in an animal model of
retinal
degeneration (M.
We show here that in porcine
retina
, GDNF receptors GFRalpha-1 and RET are expressed on
retinal
Mueller glial cells (RMG) but not on photoreceptors.
We correlate the findings to intact porcine
retina
, where GDNF induces phosphorylation of ERK in the perinuclear region of RMG located in the inner nuclear layer.
We provide here a detailed model of GDNF-induced signaling in mammalian
retina
and propose that the GDNF-induced rescue effect on mutated photoreceptors is an indirect effect mediated by
retinal
Mueller glial cells.
[MeSH-major]
Glial Cell Line-Derived Neurotrophic Factor / metabolism. Neuroglia / metabolism. Neuroprotective Agents / metabolism.
Retina
/ cytology. Signal Transduction
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[ISSN]
0270-7306
[Journal-full-title]
Molecular and cellular biology
[ISO-abbreviation]
Mol. Cell. Biol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Glial Cell Line-Derived Neurotrophic Factor; 0 / Glial Cell Line-Derived Neurotrophic Factor Receptors; 0 / Ligands; 0 / Nerve Tissue Proteins; 0 / Neural Cell Adhesion Molecules; 0 / Neuroprotective Agents; 0 / Neurturin; 0 / RNA, Messenger; 103107-01-3 / Fibroblast Growth Factor 2; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases
[Other-IDs]
NLM/ PMC1430306
53.
Conte I, Carrella S, Avellino R, Karali M, Marco-Ferreres R, Bovolenta P, Banfi S:
miR-204 is required for lens and retinal development via Meis2 targeting.
Proc Natl Acad Sci U S A
; 2010 Aug 31;107(35):15491-6
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[Title]
miR-204 is required for lens and
retinal
development via Meis2 targeting.
Morpholino-mediated ablation of miR-204 expression resulted in an eye phenotype characterized by microphthalmia, abnormal lens formation, and altered dorsoventral (D-V) patterning of the
retina
, which is associated with optic fissure coloboma.
These data provide an example of how a specific miRNA can regulate multiple events in eye formation; at the same time, they uncover an as yet unreported function of Meis2 in the specification of D-V patterning of the
retina
.
[MeSH-major]
Fish Proteins / genetics. Lens, Crystalline / metabolism. MicroRNAs / genetics.
Retina
/ metabolism. Transcription Factors / genetics
SciCrunch.
OMIM: Data: Gene Annotation
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The Lens.
Cited by Patents in
.
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[ISSN]
1091-6490
[Journal-full-title]
Proceedings of the National Academy of Sciences of the United States of America
[ISO-abbreviation]
Proc. Natl. Acad. Sci. U.S.A.
[Language]
eng
[Grant]
Italy / Telethon / / TGM06D01
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Fish Proteins; 0 / Homeodomain Proteins; 0 / MicroRNAs; 0 / Transcription Factors
[Other-IDs]
NLM/ PMC2932609
54.
Hogewind BF, Mukhopadhyay A, Theelen T, Hollander AI, Hoyng CB:
Variable clinical spectrum of the myocilin Gln368X mutation in a Dutch family with primary open angle glaucoma.
Curr Eye Res
; 2010 Jan;35(1):31-6
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She and her six siblings were examined clinically, including Heidelberg
Retina
Tomography II, and venous blood samples were screened for other variants in MYOC, WDR36, OPTN, and CYP1B1.
Two of these four siblings had glaucomatous optic disc changes with corresponding visual field losses and abnormal Heidelberg
Retina
Tomography results by the Moorfields regression analysis, one had abnormal results by the Moorfields regression analysis but no visual field loss, and one showed no glaucomatous signs or symptoms at all.
Genetic Alliance.
consumer health - Glaucoma
.
Genetic Alliance.
consumer health - Primary open angle glaucoma
.
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[ErratumIn]
Curr Eye Res. 2010 Apr;35(4):361
(PMID = 20021252.001).
[ISSN]
1460-2202
[Journal-full-title]
Current eye research
[ISO-abbreviation]
Curr. Eye Res.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Cytoskeletal Proteins; 0 / Eye Proteins; 0 / Glycoproteins; 0 / trabecular meshwork-induced glucocorticoid response protein
55.
Kiser PD, Golczak M, Lodowski DT, Chance MR, Palczewski K:
Crystal structure of native RPE65, the retinoid isomerase of the visual cycle.
Proc Natl Acad Sci U S A
; 2009 Oct 13;106(41):17325-30
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Vertebrate vision is maintained by the retinoid (visual) cycle, a complex enzymatic pathway that operates in
the retina
to regenerate the visual chromophore, 11-cis-
retinal
.
This enzyme catalyzes the conversion of all-trans-retinyl esters to 11-cis-retinol in the
retinal
pigment epithelium (RPE).
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J Biol Chem. 2009 Jan 30;284(5):3211-8
[
19049981.001
]
(PMID = 19805034.001).
[ISSN]
1091-6490
[Journal-full-title]
Proceedings of the National Academy of Sciences of the United States of America
[ISO-abbreviation]
Proc. Natl. Acad. Sci. U.S.A.
[Language]
ENG
[Grant]
United States / NEI NIH HHS / EY / R01 EY009339; United States / NIGMS NIH HHS / GM / U54-GM074945; United States / NEI NIH HHS / EY / T32 EY007157; United States / NEI NIH HHS / EY / L40 EY017820; United States / NIGMS NIH HHS / GM / U54 GM074945; United States / NEI NIH HHS / EY / EY009339-20S1; United States / NIBIB NIH HHS / EB / P03-EB09998; United States / NEI NIH HHS / EY / R01 EY009339-20S1; United States / NEI NIH HHS / EY / R01-EY009339; United States / NIBIB NIH HHS / EB / P30 EB009998
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
United States
[Chemical-registry-number]
0 / Carrier Proteins; 0 / Eye Proteins; 36-88-4 / Carotenoids; E1UOL152H7 / Iron
[Other-IDs]
NLM/ PMC2765077
56.
Pham H, Yu H, Laski FA:
Cofilin/ADF is required for retinal elongation and morphogenesis of the Drosophila rhabdomere.
Dev Biol
; 2008 Jun 1;318(1):82-91
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[Title]
Cofilin/ADF is required for
retinal
elongation and morphogenesis of the Drosophila rhabdomere.
These changes include a five-fold elongation of the
retinal
cell body and the morphogenesis of the rhabdomere, the light sensing structure of the cell.
In tsr mutants,
the retina
is shorter than normal, the result of a lack of
retinal
elongation.
We propose, and provide data supporting, that these wide rhabdomeres and adherens junctions are secondary events caused by the inhibition of
retinal
elongation.
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(PMID = 18423434.001).
[ISSN]
1095-564X
[Journal-full-title]
Developmental biology
[ISO-abbreviation]
Dev. Biol.
[Language]
ENG
[Grant]
United States / NEI NIH HHS / EY / EY014876-04; United States / NEI NIH HHS / EY / R01 EY014876-04
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
United States
[Chemical-registry-number]
0 / Actin Depolymerizing Factors; 0 / Drosophila Proteins; 0 / Microfilament Proteins; 0 / twinstar protein, Drosophila
[Other-IDs]
NLM/ NIHMS53180; NLM/ PMC2713181
57.
Bakri SJ, Pulido JS, Mukherjee P, Marler RJ, Mukhopadhyay D:
Absence of histologic retinal toxicity of intravitreal nanogold in a rabbit model.
Retina
; 2008 Jan;28(1):147-9
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[Title]
Absence of histologic
retinal
toxicity of intravitreal nanogold in a rabbit model.
PURPOSE: To evaluate the
retinal
toxicity of intravitreal nanogold, a novel antiangiogenic and long-term delivery agent.
The retina
and
retinal
pigment epithelium were otherwise histologically normal.
CONCLUSION: Intravitreal nanogold at concentrations of 67 micromol/0.1 mL and 670 micromol/0.1 mL showed no signs of
retinal
or optic nerve toxicity by light microscopy during histologic examination at 1 month.
[MeSH-major]
Gold / toxicity. Metal Nanoparticles / toxicity.
Retina
/ drug effects
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GOLD, ELEMENTAL
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(PMID = 18185152.001).
[ISSN]
0275-004X
[Journal-full-title]
Retina (Philadelphia, Pa.)
[ISO-abbreviation]
Retina (Philadelphia, Pa.)
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
7440-57-5 / Gold
58.
Beleboni RO, Guizzo R, Fontana AC, Pizzo AB, Carolino RO, Gobbo-Neto L, Lopes NP, Coutinho-Netto J, Dos Santos WF:
Neurochemical characterization of a neuroprotective compound from Parawixia bistriata spider venom that inhibits synaptosomal uptake of GABA and glycine.
Mol Pharmacol
; 2006 Jun;69(6):1998-2006
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According to our experimental glaucoma data in rat
retina
, FrPbAII is able to cross the blood-
retina
barrier and promote effective protection of
retinal
layers submitted to ischemic conditions.
[MeSH-minor]
Animals. Biological Transport / drug effects. GABA Plasma Membrane Transport Proteins / drug effects. GABA-B Receptor Agonists. Glaucoma / prevention & control. Glycine Plasma Membrane Transport Proteins / drug effects. Ion Channels / antagonists & inhibitors. Male. Rats. Rats, Inbred BB.
Retina
/ drug effects. Spiders / metabolism
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(PMID = 16551783.001).
[ISSN]
0026-895X
[Journal-full-title]
Molecular pharmacology
[ISO-abbreviation]
Mol. Pharmacol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / 2-amino-5-ureidopentanamide; 0 / GABA Plasma Membrane Transport Proteins; 0 / GABA-B Receptor Agonists; 0 / Glycine Plasma Membrane Transport Proteins; 0 / Ion Channels; 0 / Neuroprotective Agents; 0 / Spider Venoms; 56-12-2 / gamma-Aminobutyric Acid; 8W8T17847W / Urea; TE7660XO1C / Glycine
59.
Pojda-Wilczek D, Herba E, Pojda SM:
[Flash full-field electroretinography in diseases with night blindness].
Klin Oczna
; 2005;107(1-3):28-30
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PURPOSE: The aim of this study is to present similarities and differences of electroretinograms in early stages of
retinal
diseases with nyctalopia.
RESULTS: In diseases with nyctalopia the function of peripheral
retina
is markedly abnormal and scotopic ERG is significantly reduced or even absent.
Well preserved a-wave distinguished ERG of patients with stationary night blindness from the other progressive diseases
of retina
or choroid.
CONCLUSIONS: In patients with nyctalopia using ERG is possible to obtain which
retinal
elements do not work but it is only start point to following diagnostic examinations, to make proper final
diagnosis
.
[MeSH-major]
Electroretinography. Night Blindness /
diagnosis
.
Retinal
Diseases / complications
Genetic Alliance.
consumer health - Blindness
.
MedlinePlus Health Information.
consumer health - Retinal Disorders
.
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(PMID = 16052794.001).
[ISSN]
0023-2157
[Journal-full-title]
Klinika oczna
[ISO-abbreviation]
Klin Oczna
[Language]
pol
[Publication-type]
English Abstract; Journal Article
[Publication-country]
Poland
60.
Rhee KD, Yang XJ:
Function and mechanism of CNTF/LIF signaling in retinogenesis.
Adv Exp Med Biol
; 2010;664:647-54
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Ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF) exhibit multiple biological effects in the developing vertebrate
retina
.
Moreover, LIF also inhibits
retinal
vascular development.
CNTF/LIF signaling components CNTFRalpha, LIFRbeta, gp130, and a number of STAT proteins are expressed in
the retina
.
CNTF/LIF activates Jak-STAT, ERK, and Notch pathways during
retinal
development.
Perturbation of CNTF induced signal transduction reveals that different combinations of CNTF/LIF signaling pathways regulate differentiation of
retinal
neurons and glia.
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[ISSN]
0065-2598
[Journal-full-title]
Advances in experimental medicine and biology
[ISO-abbreviation]
Adv. Exp. Med. Biol.
[Language]
ENG
[Grant]
United States / NEI NIH HHS / EY / EY012270-08; United States / NEI NIH HHS / EY / R01 EY012270; United States / NEI NIH HHS / EY / R01 EY019052; United States / NEI NIH HHS / EY / R01 EY012270-08
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Ciliary Neurotrophic Factor; 0 / Leukemia Inhibitory Factor
[Other-IDs]
NLM/ NIHMS201371; NLM/ PMC3234160
61.
Mochida H, Sato K, Momose-Sato Y:
Switching of the transmitters that mediate hindbrain correlated activity in the chick embryo.
Eur J Neurosci
; 2009 Jan;29(1):14-30
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In some structures, such as
the retina
and spinal cord, it has been shown that the dominant transmitter mediating the correlated wave switches from acetylcholine to glutamate during development, although the functional significance of this phenomenon has not been clarified.
The results show for the first time that the dominant transmitter switches from acetylcholine to glutamate in a region other than
the retina
and spinal cord.
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(PMID = 19087161.001).
[ISSN]
1460-9568
[Journal-full-title]
The European journal of neuroscience
[ISO-abbreviation]
Eur. J. Neurosci.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
France
[Chemical-registry-number]
0 / Cholinergic Antagonists; 0 / Cholinesterase Inhibitors; 0 / Excitatory Amino Acid Antagonists; 0 / GABA Antagonists; 0 / Neurotransmitter Agents; 0 / Nicotinic Agonists; 3KX376GY7L / Glutamic Acid; 56-12-2 / gamma-Aminobutyric Acid; H9Y79VD43J / Strychnine; N9YNS0M02X / Acetylcholine
62.
Haeseleer F:
Interaction and colocalization of CaBP4 and Unc119 (MRG4) in photoreceptors.
Invest Ophthalmol Vis Sci
; 2008 Jun;49(6):2366-75
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CaBP4 and Unc119 colocalized in the photoreceptor synapse of adult
retina
and during postnatal
retinal
development.
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Development. 2001 Oct;128(20):4079-92
[
11641230.001
]
(PMID = 18296658.001).
[ISSN]
0146-0404
[Journal-full-title]
Investigative ophthalmology & visual science
[ISO-abbreviation]
Invest. Ophthalmol. Vis. Sci.
[Language]
ENG
[Grant]
United States / NEI NIH HHS / EY / EY014561-03; United States / NEI NIH HHS / EY / R03 EY014561; United States / NEI NIH HHS / EY / EY014561; United States / NEI NIH HHS / EY / EY001730-31; United States / NEI NIH HHS / EY / P30 EY001730; United States / NEI NIH HHS / EY / EY01730; United States / NEI NIH HHS / EY / R03 EY014561-03; United States / NEI NIH HHS / EY / P30 EY001730-31
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Adaptor Proteins, Signal Transducing; 0 / Cabp4 protein, mouse; 0 / Calcium-Binding Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / Microtubule Proteins; 0 / Nerve Tissue Proteins; 0 / Unc119 protein, mouse
[Other-IDs]
NLM/ NIHMS105394; NLM/ PMC2670247
63.
Siu AW, Lau MK, Cheng JS, Chow CK, Tam WC, Li KK, Lee DK, To TS, To CH, Do CW:
Glutamate-induced retinal lipid and protein damage: the protective effects of catechin.
Neurosci Lett
; 2008 Feb 27;432(3):193-7
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[Title]
Glutamate-induced
retinal
lipid and protein damage: the protective effects of catechin.
Glutamate toxicity has been implicated in various
retinal
diseases.
This study investigated the effects of catechin on the glutamate-treated
retina
.
Porcine
retinal
homogenates were incubated with glutamate (20 nmol) at 37 degrees C for 60 min.
Catechin was co-incubated with the glutamate-treated
retina
in the same condition.
Glutamate increased the
retinal
MDA (p<0.0001) and catechin reversed the effect (p<0.0001).
Our study shows that (a)
retinal
glutamate toxicity is mediated by LPO and protein modification, and (b) catechin ameliorates the toxicity.
[MeSH-major]
Catechin / pharmacology. Glutamic Acid / toxicity. Lipid Peroxidation / drug effects.
Retina
/ drug effects
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(PMID = 18249068.001).
[ISSN]
0304-3940
[Journal-full-title]
Neuroscience letters
[ISO-abbreviation]
Neurosci. Lett.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Ireland
[Chemical-registry-number]
0 / Proteins; 3KX376GY7L / Glutamic Acid; 4Y8F71G49Q / Malondialdehyde; 8R1V1STN48 / Catechin
64.
Melbourne-Chambers R, Singh Minott I, Mowatt L, Johnson P, Thame M:
Aicardi syndrome associated with anterior cephalocele in a female infant.
Dev Med Child Neurol
; 2007 Jun;49(6):464-6
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Ophthalmological evaluation revealed left exotropia, dysplastic optic discs and
retina
, 'morning glory' appearance of the left optic disc, and bilateral chorioretinal lacunae.
[MeSH-major]
Agenesis of Corpus Callosum. Choroid / abnormalities. Encephalocele / complications. Encephalocele / physiopathology. Ethmoid Sinus / abnormalities.
Retina
/ abnormalities. Spasms, Infantile / complications
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(PMID = 17518934.001).
[ISSN]
0012-1622
[Journal-full-title]
Developmental medicine and child neurology
[ISO-abbreviation]
Dev Med Child Neurol
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
England
65.
Abramowicz MJ, Ribai P, Cordonnier M:
Congenital stationary night blindness: report of an autosomal recessive family and linkage analysis.
Am J Med Genet A
; 2005 Jan 1;132A(1):76-9
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Congenital stationary night blindness (CSNB) is a group of rare, non-progressive conditions of the
retina
characterized by abnormal rod function causing impaired night vision.
The latter determine lamina-specific connectivity in
the retina
, a histological substrate of the ON pathway implicated in complete, Schubert-Bornschein CSNB.
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[Copyright]
(c) 2004 Wiley-Liss, Inc.
(PMID = 15551339.001).
[ISSN]
1552-4825
[Journal-full-title]
American journal of medical genetics. Part A
[ISO-abbreviation]
Am. J. Med. Genet. A
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / FMR1 protein, human; 0 / Nerve Tissue Proteins; 0 / RNA-Binding Proteins; 0 / Receptors, Androgen; 139135-51-6 / Fragile X Mental Retardation Protein
66.
Kalathur RK, Gagniere N, Berthommier G, Poidevin L, Raffelsberger W, Ripp R, Léveillard T, Poch O:
RETINOBASE: a web database, data mining and analysis platform for gene expression data on retina.
BMC Genomics
; 2008;9:208
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[Title]
RETINOBASE: a web database, data mining and analysis platform for gene expression data on
retina
.
BACKGROUND:
The retina
is a multi-layered sensory tissue that lines the back of the eye and acts at the interface of input light and visual perception.
Defects in any of these cells can lead to a variety of
retinal
diseases, including age-related macular degeneration, retinitis pigmentosa, Leber congenital amaurosis and glaucoma.
Recent progress in genomics and microarray technology provides extensive opportunities to examine alterations in
retinal
gene expression profiles during development and diseases.
However, there is no specific database that deals with
retinal
gene expression profiling.
In this context we have built RETINOBASE, a dedicated microarray database for
retina
.
DESCRIPTION: RETINOBASE is a microarray relational database, analysis and visualization system that allows simple yet powerful queries to retrieve information about gene expression in
retina
.
It provides access to gene expression meta-data and offers significant insights into gene networks in
retina
, resulting in better hypothesis framing for biological problems that can subsequently be tested in the laboratory.
Thus, RETINOBASE provides a framework to compare these methods and to optimize the
retinal
data analysis.
Overall, RETINOBASE provides efficient access to the global expression profiling of
retinal
genes from different organisms under various conditions.
[MeSH-major]
Databases, Genetic. Gene Expression Profiling. Internet.
Retina
FlyBase.
FlyBase
.
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Invest Ophthalmol Vis Sci. 2006 Mar;47(3):977-85
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(PMID = 18457592.001).
[ISSN]
1471-2164
[Journal-full-title]
BMC genomics
[ISO-abbreviation]
BMC Genomics
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Other-IDs]
NLM/ PMC2386825
67.
Venkataraman ST, Flanagan JG, Hudson C:
Vascular reactivity of optic nerve head and retinal blood vessels in glaucoma--a review.
Microcirculation
; 2010 Oct;17(7):568-81
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[Title]
Vascular reactivity of optic nerve head and
retinal
blood vessels in glaucoma--a review.
Glaucoma is characterized by loss of
retinal
nerve fibers, structural changes to the optic nerve, and an associated change in visual function.
It has been proposed that primary open angle glaucoma could be associated with structural abnormalities and/or functional dysregulation of the vasculature supplying the optic nerve and surrounding
retinal
tissue.
Under normal conditions, blood flow is autoregulated, i.e., maintained at a relatively constant level, in
the retina
and ONH, irrespective of variation in ocular perfusion pressure.
A number of factors released by the vascular endothelium, including endothelin-1 and nitric oxide, are suggested to play an important role in the regulation of local perfusion in
the retina
and ONH.
[MeSH-major]
Glaucoma / physiopathology. Optic Disk / blood supply.
Retinal
Vessels / physiopathology
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.
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[Copyright]
© 2010 John Wiley & Sons Ltd.
(PMID = 21040122.001).
[ISSN]
1549-8719
[Journal-full-title]
Microcirculation (New York, N.Y. : 1994)
[ISO-abbreviation]
Microcirculation
[Language]
eng
[Grant]
Canada / Canadian Institutes of Health Research / /
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't; Review
[Publication-country]
United States
68.
Witkovsky P, Gábriel R, Krizaj D:
Anatomical and neurochemical characterization of dopaminergic interplexiform processes in mouse and rat retinas.
J Comp Neurol
; 2008 Sep 10;510(2):158-74
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Dopaminergic (
DA
) neurons of mouse and rat retinas are of the interplexiform subtype (
DA
-IPC), i.e., they send processes distally toward the outer
retina
, exhibiting numerous varicosities along their course.
The primary question we addressed was whether distally located
DA
-IPC varicosities, identified by tyrosine hydroxylase (TH) immunoreactivity, had the characteristic presynaptic proteins associated with calcium-dependent vesicular release of neurotransmitter.
We found that TH immunoreactive varicosities in the outer
retina
possessed vesicular monoamine transporter 2 and vesicular GABA transporter, but they lacked immunostaining for any of nine subtypes of voltage-dependent calcium channel.
Immunoreactivity for other channels that may permit calcium influx such as certain ionotropic glutamate receptors and canonical transient receptor potential channels (TRPCs) was similarly absent, although
DA
-IPC varicosities did show ryanodine receptor immunoreactivity, indicating the presence of intracellular calcium stores.
The synaptic vesicle proteins sv2a and sv2b and certain other proteins associated with the presynaptic membrane were absent from
DA
-IPC varicosities, but the vesicular SNARE protein, vamp2, was present in a fraction of those varicosities.
Outer
retinal
varicosities of this putative GABAergic IPC did colocalize synaptic vesicle protein 2a, suggesting they possessed a conventional vesicular release mechanism.
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[Copyright]
(c) 2008 Wiley-Liss, Inc.
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11977117.001
]
(PMID = 18615559.001).
[ISSN]
1096-9861
[Journal-full-title]
The Journal of comparative neurology
[ISO-abbreviation]
J. Comp. Neurol.
[Language]
ENG
[Grant]
United States / NEI NIH HHS / EY / EY013870-07; United States / NEI NIH HHS / EY / R01 EY013870; United States / NEI NIH HHS / EY / EY 13870; United States / NEI NIH HHS / EY / R01 EY013870-07
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Ryanodine Receptor Calcium Release Channel; 0 / Sodium Channels; EC 1.14.16.2 / Tyrosine 3-Monooxygenase; SY7Q814VUP / Calcium; VTD58H1Z2X / Dopamine
[Other-IDs]
NLM/ NIHMS227029; NLM/ PMC2923661
69.
Shields CL, Perez B, Benavides R, Materin MA, Shields JA:
Optical coherence tomography of optic disk melanocytoma in 15 cases.
Retina
; 2008 Mar;28(3):441-6
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MAIN OUTCOME MEASURES: OCT characteristics of the
tumor
.
By ophthalmoscopy, the mean basal diameter of the
tumor
was 2.7 mm, and by ultrasonography, the mean thickness was 1.8 mm.
By OCT, the
tumor
showed a nodular appearance in 14 cases (93%).
The
tumor
displayed a gradual sloping transition from normal
retina
into the mass, hyperreflectivity at its anterior
tumor
surface, and dense posterior shadowing with an optically empty appearance in all 15 cases (100%).
There were no internal qualities of the
tumor
or disk visible by OCT due to dense shadowing.
Other findings of OCT included vitreous seeds in 2 cases (13%) and adjacent
retinal
edema in 1 case (7%).
There were no cases of
retinal
traction, subretinal fluid, macular edema, or epiretinal membrane in the macula.
CONCLUSIONS: Optic disk melanocytoma shows characteristic features by OCT including a gradual transition from normal
retina
into nodular
tumor
, and the mass displays a bright anterior border layer with optically empty internal details.
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(PMID = 18327136.001).
[ISSN]
0275-004X
[Journal-full-title]
Retina (Philadelphia, Pa.)
[ISO-abbreviation]
Retina (Philadelphia, Pa.)
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
70.
Bennicelli J, Wright JF, Komaromy A, Jacobs JB, Hauck B, Zelenaia O, Mingozzi F, Hui D, Chung D, Rex TS, Wei Z, Qu G, Zhou S, Zeiss C, Arruda VR, Acland GM, Dell'Osso LF, High KA, Maguire AM, Bennett J:
Reversal of blindness in animal models of leber congenital amaurosis using optimized AAV2-mediated gene transfer.
Mol Ther
; 2008 Mar;16(3):458-65
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Immunohistochemistry confirmed transduction of
retinal
pigment epithelium cells and there was minimal toxicity to
the retina
as judged by histopathologic analysis.
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(PMID = 18209734.001).
[ISSN]
1525-0024
[Journal-full-title]
Molecular therapy : the journal of the American Society of Gene Therapy
[ISO-abbreviation]
Mol. Ther.
[Language]
eng
[Grant]
United States / NEI NIH HHS / EY / R01 EY010820-13; United States / NEI NIH HHS / EY / R01 EY006855; United States / NEI NIH HHS / EY / EY06855; United States / NEI NIH HHS / EY / EY10820; United States / NEI NIH HHS / EY / EY015398; United States / NEI NIH HHS / EY / K12 EY015398; United States / NEI NIH HHS / EY / R01 EY010820; United States / NEI NIH HHS / EY / R01 EY010820-09
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Carrier Proteins; 0 / Eye Proteins; EC 3.1.1.64 / retinoid isomerohydrolase; EC 5.2.- / cis-trans-Isomerases
[Other-IDs]
NLM/ NIHMS176415; NLM/ PMC2842085
71.
Stieger K, Mendes-Madeira A, Meur GL, Weber M, Deschamps JY, Nivard D, Provost N, Moullier P, Rolling F:
Oral administration of doxycycline allows tight control of transgene expression: a key step towards gene therapy of retinal diseases.
Gene Ther
; 2007 Dec;14(23):1668-73
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[Title]
Oral administration of doxycycline allows tight control of transgene expression: a key step towards gene therapy of
retinal
diseases.
Gene transfer of neurotrophic or antiangiogenic factors has been shown to improve photoreceptor survival in
retinal
degenerative disorders (that is retinitis pigmentosa) and to prevent neovascularization in
retinal
vascular diseases (that is age-related macular degeneration, diabetic retinopathy).
In a previous study, we demonstrated that rAAV-mediated gene transfer of the tetracycline-regulatable (tetR) system allows transgene regulation in
the retina
of nonhuman primates after intravenous administration of doxycycline (Dox).
The purpose of this study was to evaluate oral administration of Dox to control transgene expression in
the retina
, since the pharmacokinetics after oral administration of the inducer drug represent a key factor when considering advancing to clinical trials.
[MeSH-major]
Anti-Bacterial Agents / administration & dosage. Doxycycline / administration & dosage. Genetic Therapy / methods.
Retinal
Diseases / therapy
[MeSH-minor]
Administration, Oral. Animals. Dependovirus / genetics. Dose-Response Relationship, Drug. Erythropoietin / analysis. Erythropoietin / genetics. Gene Expression / drug effects. Genetic Vectors / administration & dosage. Genetic Vectors / genetics. Macaca. Models, Animal.
Retina
/ chemistry. Transgenes
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consumer health - Retinal Disorders
.
Hazardous Substances Data Bank.
DOXYCYCLINE
.
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(PMID = 17914405.001).
[ISSN]
0969-7128
[Journal-full-title]
Gene therapy
[ISO-abbreviation]
Gene Ther.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Anti-Bacterial Agents; 11096-26-7 / Erythropoietin; N12000U13O / Doxycycline
72.
Denny CA, Alroy J, Pawlyk BS, Sandberg MA, d'Azzo A, Seyfried TN:
Neurochemical, morphological, and neurophysiological abnormalities in retinas of Sandhoff and GM1 gangliosidosis mice.
J Neurochem
; 2007 Jun;101(5):1294-302
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Retinal
abnormalities are well documented in patients with ganglioside storage diseases.
The total content and distribution of
retinal
glycosphingolipids was studied for the first time in control mice and in Sandhoff disease (SD) and GM1 gangliosidosis mice.
Similar to previous findings in rat
retina
, GD3 was the major ganglioside in mouse
retina
, while GM2 and GM1 were minor species.
Our findings present a model system for assessing
retinal
pathobiology and therapies for the gangliosidoses.
[MeSH-major]
Gangliosidosis, GM1 / genetics.
Retina
/ metabolism.
Retina
/ pathology. Sandhoff Disease / pathology. Sandhoff Disease / physiopathology
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(PMID = 17442056.001).
[ISSN]
0022-3042
[Journal-full-title]
Journal of neurochemistry
[ISO-abbreviation]
J. Neurochem.
[Language]
eng
[Grant]
United States / NEI NIH HHS / EY / EY016350; United States / NICHD NIH HHS / HD / HD39722; United States / NIDDK NIH HHS / DK / R01-DK52025
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
EC 3.2.1.23 / beta-Galactosidase; EC 3.2.1.52 / beta-N-Acetylhexosaminidases
73.
Zamiri P, Sugita S, Streilein JW:
Immunosuppressive properties of the pigmented epithelial cells and the subretinal space.
Chem Immunol Allergy
; 2007;92:86-93
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The PE cells of the iris, ciliary body, and
retina
reside in anatomically disparate locations and serve distinctly different functions, yet share interesting immunomodulatory properties that contribute to ocular immune privilege.
PE cells in the ciliary body and
retina
elaborate a variety of soluble factors that either directly or indirectly dampen immune-mediated inflammation; these include transforming growth factor-Beta, somatostatin, thrombospondin and pigment epithelial derived factor (PEDF).
The prospect of therapeutic
retinal
transplantation and the possible immunologic etiology for some forms of age-related macular degeneration provides new impetus for gaining a better understanding of ocular immune privilege in the posterior regions of the eye.
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(PMID = 17264485.001).
[ISSN]
1660-2242
[Journal-full-title]
Chemical immunology and allergy
[ISO-abbreviation]
Chem Immunol Allergy
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
Switzerland
[Chemical-registry-number]
0 / Thrombospondin 1; 0 / Transforming Growth Factor beta
[Number-of-references]
48
74.
Santiago AR, Pereira TS, Garrido MJ, Cristóvão AJ, Santos PF, Ambrósio AF:
High glucose and diabetes increase the release of [3H]-D-aspartate in retinal cell cultures and in rat retinas.
Neurochem Int
; 2006 May-Jun;48(6-7):453-8
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[Title]
High glucose and diabetes increase the release of [3H]-D-aspartate in
retinal
cell cultures and in rat retinas.
Several evidences suggest that glutamate may be involved in
retinal
neurodegeneration in diabetic retinopathy (DR).
The accumulation of [(3)H]-D-aspartate did not change in cultured
retinal
neural cells treated with high glucose (30 mM) for 7 days.
However, the release of [(3)H]-D-aspartate, evoked by 50 mM KCl, significantly increased in
retinal
cells exposed to high glucose.
These results suggest that high glucose and diabetes increase the evoked release of D-aspartate in
the retina
, which may be correlated with the hypothesis of glutamate-induced
retinal
neurodegeneration in DR.
[MeSH-major]
Aspartic Acid / metabolism. Diabetes Mellitus, Experimental / metabolism. Glucose / metabolism.
Retina
/ metabolism