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1. Lanteri R, Rapisarda C, Santangelo M, Di Cataldo A, Licata A: Ancient schwannoma of the facial nerve: a case report. Chir Ital; 2005 May-Jun;57(3):381-3
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  • Ancient schwannomas are rare benign tumours, deriving from neural crest cells.
  • Ultrasonography of the parotid gland demonstrated the presence of a nodule, with irregular borders, measuring about 2.90 x 2.00 x 1.70 cm.
  • During surgery we found a mass apparently spreading from the parotid gland and therefore we decided to resect the mass together with the gland.
  • The histological examination yielded a diagnosis of ancient schwannoma.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Facial Nerve Diseases / surgery. Neurilemmoma / surgery. Parotid Neoplasms / surgery

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  • (PMID = 16231830.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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2. Stock M, Dörr W, Stromberger C, Mock U, Koizar S, Pötter R, Georg D: Investigations on parotid gland recovery after IMRT in head and neck tumor patients. Strahlenther Onkol; 2010 Dec;186(12):665-71
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  • [Title] Investigations on parotid gland recovery after IMRT in head and neck tumor patients.
  • The main motivation is sparing the parotid gland and reduction of xerostomia.
  • Generally, relative parotid volumes have been evaluated for treatment outcome and planning constraints, neglecting that absolute parotid volumes can vary significantly.
  • The aim of the present study was to investigate changes in parotid gland function and set this in relation to absolute volumes.
  • MATERIAL AND METHODS: 46 head and neck patients were treated by sparing at least the contralateral parotid gland.
  • The mean dose to the contralateral gland was limited to 26 Gy.
  • Parotid function was measured with scintigraphy before and at 3, 6, 9, and 12 months after radiotherapy.
  • Gland recovery was correlated with absolute parotid gland volumes and mean dose.
  • Longer recovery times show higher ED50 values indicating partial regeneration of gland functions.
  • [MeSH-major] Mouth Neoplasms / radiotherapy. Oropharyngeal Neoplasms / radiotherapy. Parotid Gland / diagnostic imaging. Parotid Gland / radiation effects. Radiation Injuries / diagnostic imaging. Radionuclide Imaging. Radiotherapy, Intensity-Modulated / adverse effects
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoadjuvant Therapy. Neoplasm Staging. Radiotherapy Dosage. Radiotherapy, Adjuvant. Salivation / radiation effects. Sodium Pertechnetate Tc 99m. Xerostomia / diagnostic imaging. Young Adult

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  • (PMID = 21136030.001).
  • [ISSN] 1439-099X
  • [Journal-full-title] Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
  • [ISO-abbreviation] Strahlenther Onkol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] A0730CX801 / Sodium Pertechnetate Tc 99m
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3. Molino JA, Guillén G, Peiró JL, García-Vaquero JA, Marhuenda C, Carreras E, Lloret J, Martínez-Ibáñez V: [Cervical cystic lymphangioma: still a challenge]. Cir Pediatr; 2010 Jul;23(3):147-52
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  • This paper analyzes our surgical results, the value of prenatal diagnosis and the use of new techniques such as the EXIT procedure for airway control in sereve cases.
  • Data referred to prenatal diagnosis, intrapartum airway management, surgical procedures and morbidity, sclerosing substance infiltration and long term sequelae was analyzed.
  • The tongue was affected in 30.7%, parotid glands in 38.4% and airway in 38.4%.
  • Tongue or parotid gland infiltration are difficult to treat.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / surgery. Lymphangioma, Cystic / diagnosis. Lymphangioma, Cystic / surgery
  • [MeSH-minor] Humans. Infant, Newborn. Prenatal Diagnosis. Retrospective Studies

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  • (PMID = 23155660.001).
  • [ISSN] 0214-1221
  • [Journal-full-title] Cirugía pediátrica : organo oficial de la Sociedad Española de Cirugía Pediátrica
  • [ISO-abbreviation] Cir Pediatr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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4. Veness MJ, Palme CE, Morgan GJ: High-risk cutaneous squamous cell carcinoma of the head and neck: results from 266 treated patients with metastatic lymph node disease. Cancer; 2006 Jun 1;106(11):2389-96
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  • METHODS: Patients were identified who had metastatic cSCC to lymph nodes (parotid and cervical) of the HN and who were treated within the context of a multidisciplinary HN cancer service between 1980 and 2005 at Westmead Hospital (Sydney, Australia).
  • The majority of metastatic lymph nodes (162 of 266 lymph nodes; 61%) were located in the parotid with or without cervical lymph node involvement.
  • The median tumor thickness was 6 mm (range, 0.5-28 mm), and the median tumor size was 15 mm (range, 3-70 mm).
  • Recurrent cSCC was present in 15% of patients, and most lesions were located within the lymphatic drainage of the parotid on the temple/forehead (28%), on or around the ear (20%), or on the cheek (12%).
  • CONCLUSIONS: Data from this large, prospective data base, in concordance with other series, suggested that a patient with thick cSCC (>4-5 mm) located in proximity to the parotid gland can be considered at high-risk.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Prospective Studies. Risk Factors


5. Lee BH: Unilateral agenesis of the parotid gland associated with a pleomorphic adenoma in the ipsilateral buccal space. Jpn J Radiol; 2010 Apr;28(3):224-6
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  • [Title] Unilateral agenesis of the parotid gland associated with a pleomorphic adenoma in the ipsilateral buccal space.
  • Unilateral agenesis of the parotid gland is a rare condition.
  • Although pleomorphic adenomas are the most common benign glandular tumors of the buccal space, to the author's knowledge unilateral agenesis of the parotid gland associated with pleomorphic adenoma in the ipsilatearal buccal space has not been previously described in the literature.
  • [MeSH-major] Adenoma, Pleomorphic / diagnostic imaging. Cheek. Parotid Gland / abnormalities
  • [MeSH-minor] Aged. Female. Humans. Salivary Gland Neoplasms / diagnostic imaging. Salivary Glands, Minor. Tomography, X-Ray Computed

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  • (PMID = 20437134.001).
  • [ISSN] 1867-108X
  • [Journal-full-title] Japanese journal of radiology
  • [ISO-abbreviation] Jpn J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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6. Chen L, Liu F, Fan X, Gao J, Chen N, Wong T, Wu J, Wen SW: Detection of hepatitis B surface antigen, hepatitis B core antigen, and hepatitis B virus DNA in parotid tissues. Int J Infect Dis; 2009 Jan;13(1):20-3
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  • [Title] Detection of hepatitis B surface antigen, hepatitis B core antigen, and hepatitis B virus DNA in parotid tissues.
  • OBJECTIVE: To examine the presence of hepatitis B surface antigen (HBsAg), hepatitis B core antigen (HBcAg), and hepatitis B virus (HBV) DNA in parotid tissues from patients with positive serum HBV markers.
  • METHODS: HBsAg and HBcAg were examined in parotid biopsy tissues from patients with suspected parotid tumor and positive serum HBV markers by immunocytochemistry, and HBV DNA was detected in parotid tissues by PCR.
  • RESULTS: Among the 22 patients with a parotid tumor, only one was pathologically confirmed as a neoplasm; all others were benign.
  • HBsAg and HBcAg were present in parotid cells with positive rates of 45.5% (10/22) and 40.9% (9/22), respectively, with an overall positive rate of 54.5% (12/22).
  • Of the 22 cases with serum markers of HBV infection, seven (31.8%) had both HBsAg and HBcAg in the parotid cells.
  • [MeSH-major] DNA, Viral / analysis. Hepatitis B / virology. Hepatitis B Core Antigens / analysis. Hepatitis B Surface Antigens / analysis. Hepatitis B virus / isolation & purification. Parotid Gland / virology

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  • (PMID = 18539066.001).
  • [ISSN] 1878-3511
  • [Journal-full-title] International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
  • [ISO-abbreviation] Int. J. Infect. Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / Hepatitis B Core Antigens; 0 / Hepatitis B Surface Antigens
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7. Feng GD, Gao ZQ, Ni DF, Wang WZ, Jiang H, Quan SM, Zha Y: [Clinical analysis of primary facial nerve neuroma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Jan;43(1):32-6
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  • OBJECTIVE: To analyze the clinical features of facial nerve neuroma about its diagnosis and management.
  • RESULTS: The patients complained of facial paralysis in 7 cases, otitis media in 1 case, a mass in parotid gland in 1 case and a mass on the side of the orbital on face in 1 case.
  • Intraoperative findings showed that the tumor location matched the image findings.
  • Postoperative pathological diagnosis demonstrated 8 Schwannoma, 2 neurofibroma.
  • There was partial tumor resection in 1 patient accepted and his nerve function was unchanged.
  • Two patients underwent tumor resection while the continuity of facial nerve was preserved as result their facial nerve function improved respectively.
  • [MeSH-minor] Adolescent. Adult. Facial Paralysis / diagnosis. Facial Paralysis / etiology. Female. Humans. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 18357709.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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8. Oates J, Clark JR, Read J, Reeves N, Gao K, O'Brien CJ: Integration of prospective quality of life and nutritional assessment as routine components of multidisciplinary care of patients with head and neck cancer. ANZ J Surg; 2008 Jan-Feb;78(1-2):34-41
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  • Examples of QOL and nutritional data for patients with cancers of the oral cavity, oropharynx, nasopharynx, larynx, hypopharynx, parotid gland and paranasal sinus, and also unknown primary cancers are given.

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  • (PMID = 18199203.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Australia
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9. Al-Zaher N, Obeid A, Al-Salam S, Al-Kayyali BS: Acinic cell carcinoma of the salivary glands: a literature review. Hematol Oncol Stem Cell Ther; 2009;2(1):259-64
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  • Acinic cell carcinoma (ACC) is a low-grade malignant salivary neoplasm that constitutes approximately 17% of primary salivary gland malignancies.
  • In the head and neck region, the parotid gland is the predominant site of origin and women are usually more frequently diagnosed than men.
  • A slowly enlarging mass lesion in the tail of the parotid gland is the most frequent presentation.
  • The diagnosis is usually confirmed with a fine needle aspiration biopsy, and surgical excision is the main treatment of this malignant neoplasm.
  • [MeSH-major] Carcinoma, Acinar Cell / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 20063555.001).
  • [ISSN] 1658-3876
  • [Journal-full-title] Hematology/oncology and stem cell therapy
  • [ISO-abbreviation] Hematol Oncol Stem Cell Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 59
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10. Vaudaux JD, Moulin AP, Olivier F, Guex-Crosier Y: Parotid gland fine-needle aspiration biopsy in the diagnosis of ocular sarcoidosis. Klin Monbl Augenheilkd; 2010 Apr;227(4):328-9
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  • [Title] Parotid gland fine-needle aspiration biopsy in the diagnosis of ocular sarcoidosis.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Eye Diseases / pathology. Parotid Gland / pathology. Sarcoidosis / pathology

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  • (PMID = 20408089.001).
  • [ISSN] 1439-3999
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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11. Münter MW, Hoffner S, Hof H, Herfarth KK, Haberkorn U, Rudat V, Huber P, Debus J, Karger CP: Changes in salivary gland function after radiotherapy of head and neck tumors measured by quantitative pertechnetate scintigraphy: comparison of intensity-modulated radiotherapy and conventional radiation therapy with and without Amifostine. Int J Radiat Oncol Biol Phys; 2007 Mar 1;67(3):651-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Changes in salivary gland function after radiotherapy of head and neck tumors measured by quantitative pertechnetate scintigraphy: comparison of intensity-modulated radiotherapy and conventional radiation therapy with and without Amifostine.
  • PURPOSE: The aim of this study was to compare changes in salivary gland function after intensity-modulated radiotherapy (IMRT) and conventional radiotherapy (RT), with or without Amifostine, for tumors of the head-and-neck region using quantitative salivary gland scintigraphy (QSGS).
  • METHODS AND MATERIALS: A total of 75 patients received pre- and post-therapeutic QSGS to quantify the salivary gland function.
  • Changes in the maximum uptake (DeltaU) and relative excretion rate (DeltaF) both pre- and post-RT were determined to characterize radiation-induced changes in the salivary gland function.
  • For the parotid glands, the reduction was smaller for the IMRT-low than for the IMRT-high group.
  • For the Amifostine-high and the conventional group the difference was significant only for one parameter (DeltaU, parotid and submandibular glands, p < 0.05).
  • In regard to the endpoint "reduction of the salivary gland excretion rate of more than 50%," the dose-response curves yielded D50-values of 34.2 +/- 12.2 Gy for the conventionally treated group and 36.8 +/- 2.9 Gy for the IMRT group.
  • CONCLUSION: Intensity-modulated RT can significantly reduce the loss of parotid gland function when respecting a certain dose threshold.
  • Conventional RT plus Amifostine prevents reduced salivary gland function only in the patient group treated with <40.6 Gy.
  • [MeSH-minor] Adult. Aged. Amifostine / therapeutic use. Dose-Response Relationship, Radiation. Female. Humans. Logistic Models. Male. Middle Aged. Parotid Gland / radiation effects. Parotid Gland / radionuclide imaging. Radiation-Protective Agents / therapeutic use. Salivation / radiation effects. Xerostomia / etiology. Xerostomia / radionuclide imaging

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  • [CommentIn] Int J Radiat Oncol Biol Phys. 2007 Dec 1;69(5):1651-2; author reply 1652 [18035221.001]
  • [CommentIn] Int J Radiat Oncol Biol Phys. 2007 Sep 1;69(1):318; author reply 318-9 [17707287.001]
  • (PMID = 17175118.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiation-Protective Agents; 0 / Radiopharmaceuticals; A0730CX801 / Sodium Pertechnetate Tc 99m; M487QF2F4V / Amifostine
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12. Vrijheid M, Cardis E, Armstrong BK, Auvinen A, Berg G, Blaasaas KG, Brown J, Carroll M, Chetrit A, Christensen HC, Deltour I, Feychting M, Giles GG, Hepworth SJ, Hours M, Iavarone I, Johansen C, Klaeboe L, Kurttio P, Lagorio S, Lönn S, McKinney PA, Montestrucq L, Parslow RC, Richardson L, Sadetzki S, Salminen T, Schüz J, Tynes T, Woodward A, Interphone Study Group: Validation of short term recall of mobile phone use for the Interphone study. Occup Environ Med; 2006 Apr;63(4):237-43
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  • This large random error can be expected to reduce the power of the Interphone study to detect an increase in risk of brain, acoustic nerve, and parotid gland tumours with increasing mobile phone use, if one exists.

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  • (PMID = 16556742.001).
  • [ISSN] 1470-7926
  • [Journal-full-title] Occupational and environmental medicine
  • [ISO-abbreviation] Occup Environ Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2078087
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13. Silas OA, Echejoh GO, Manasseh AN, Mandong BM: Patterns of malignant salivary gland tumours in Jos University Teaching Hospital (JUTH), Jos: a ten-year retrospective study. Niger J Med; 2009 Jul-Sep;18(3):282-5
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  • [Title] Patterns of malignant salivary gland tumours in Jos University Teaching Hospital (JUTH), Jos: a ten-year retrospective study.
  • BACKGROUND: Salivary gland tumours are common head and neck tumours and more common in western world than Africans.
  • Most salivary gland tumours are benign but the morbidity and mortality as expected is higher with malignant tumours.
  • This study is aimed at describing the histological pattern, age, sex and site distribution of malignant salivary gland tumours in Jos University Teaching Hospital (JUTH) Jos from January 1998 to December 2007.
  • METHODS: This is a descriptive study of all histologically confirmed malignant salivary gland tumours over a period of ten years.
  • Diagnosis was made and classification done according to the World Health Organisation (WHO) classification of salivary gland tumours 3.
  • Malignant salivary gland tumours occurred more within the age range 40 to 69 years with the age group 50-59 years accounting for the highest frequency (36 cases).
  • Most of these malignant salivary gland tumours occurred more in the parotid gland, the minor salivary being the least site of occurrence.
  • CONCLUSION: Mucoeperdermiod carcinoma is the commonest salivary gland tumour and that malignant salivary gland tumours in this study and it occurred more after the 5th decade of life.
  • [MeSH-major] Carcinoma, Mucoepidermoid / epidemiology. Salivary Gland Neoplasms / epidemiology

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  • (PMID = 20120646.001).
  • [ISSN] 1115-2613
  • [Journal-full-title] Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria
  • [ISO-abbreviation] Niger J Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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14. Kodaira T, Tomita N, Tachibana H, Nakamura T, Nakahara R, Inokuchi H, Fuwa N: Aichi cancer center initial experience of intensity modulated radiation therapy for nasopharyngeal cancer using helical tomotherapy. Int J Radiat Oncol Biol Phys; 2009 Mar 15;73(4):1129-34
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  • The primary tumor and involved lymph node (PTV1) were prescribed 70 Gy and the prophylactic region 54 Gy at D95, respectively.
  • Parotid function was evaluated using quantitative scintigraphy at pretreatment, and posttreatment at 3 months and 1 year later.
  • Parotid gland function at 1 year after completion of IMRT was significantly improved compared with that at 3 months.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antineoplastic Agents / adverse effects. Antineoplastic Agents / therapeutic use. Cancer Care Facilities. Feasibility Studies. Female. Humans. Japan. Male. Middle Aged. Parotid Gland / physiopathology. Parotid Gland / radiation effects. Radiotherapy Dosage. Remission Induction. Tomography, Spiral Computed / instrumentation. Tomography, Spiral Computed / methods. Treatment Outcome. Young Adult

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  • (PMID = 18922651.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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15. Ridder GJ, Boedeker CC, Technau-Ihling K, Sander A: Cat-scratch disease: Otolaryngologic manifestations and management. Otolaryngol Head Neck Surg; 2005 Mar;132(3):353-8
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  • Atypical manifestation of CSD including Parinaud's oculoglandular syndrome, swelling of the parotid gland and erythema nodosum were diagnosed in 8.1%, 8.1%, and 2.0% of cases, respectively.
  • CONCLUSIONS: Our results demonstrate that CSD is a major cause of enlarged cervicofacial lymph nodes and should therefore be included in the differential diagnosis of lymphadenopathy in the head and neck region.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Prospective Studies

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  • (PMID = 15746844.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Chen MF, Ueng SH, Jung SM, Chen YL, Chang KP: A type II first branchial cleft cyst masquerading as an infected parotid Warthin's tumor. Chang Gung Med J; 2006 Jul-Aug;29(4):435-9
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  • [Title] A type II first branchial cleft cyst masquerading as an infected parotid Warthin's tumor.
  • The diagnosis of a parotid mass usually depends on thorough history taking and physical examination.
  • Diagnostic modalities, including ultrasonographic examinations, computed tomography and magnetic resonance images, may also provide substantial information but their accuracy for diagnosis is sometimes questionable, especially in differentiating some rare neoplasms.
  • First branchial cleft cysts (FBCCs) are rare causes of parotid swelling and comprise less than 1% of all branchial anomalies.
  • We present a case of type II FBCC masquerading as an infected parotid Warthin's tumor.
  • We also review the clinical signs and symptoms of FBCCs in order to remind clinicians that this rare branchial anomaly can mimic an infected Warthin's tumor and may be seated in the deep lobe of the parotid gland.
  • By making an accurate pre-operative diagnosis of type II FBCC, we can minimize surgical morbidity and avoid incomplete resection and possible recurrence.
  • [MeSH-major] Adenolymphoma / diagnosis. Branchioma / diagnosis. Head and Neck Neoplasms / diagnosis. Parotid Neoplasms / diagnosis

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  • (PMID = 17051844.001).
  • [ISSN] 2072-0939
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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17. Sadetzki S, Oberman B, Mandelzweig L, Chetrit A, Ben-Tal T, Jarus-Hakak A, Duvdevani S, Cardis E, Wolf M: Smoking and risk of parotid gland tumors: a nationwide case-control study. Cancer; 2008 May 1;112(9):1974-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Smoking and risk of parotid gland tumors: a nationwide case-control study.
  • BACKGROUND: Because existing data regarding the relation between smoking and salivary gland tumors are sparse, tobacco is currently not classified as a salivary gland carcinogen.
  • The objective of the current study was to assess the association between smoking and benign and malignant parotid gland tumors (PGTs) in a nationwide study.
  • Analysis by histologic type indicated remarkably high risks for Warthin tumor (OR for ever cigarette smokers: 15.3; 95% CI, 6.1-38.5).
  • CONCLUSIONS: Smoking plays an important role in the development of Warthin tumor.
  • [MeSH-major] Parotid Neoplasms / etiology. Smoking / adverse effects

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  • [ErratumIn] Cancer. 2008 Aug 1;113(3):662-3
  • (PMID = 18361448.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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18. Koch M, Dimmler A, Alexiou C: [Recurrent and metastasizing atypical fibroxanthoma]. HNO; 2008 Oct;56(10):1046-51
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  • Atypical fibroxanthoma is a rare skin tumor that arises particularly on sun-exposed skin.
  • Although it is considered to be a benign tumor, rarely, metastases arise.
  • With the second relapse, a single metastasis in the right parotid gland was detected.
  • A complete tumor excision was performed, and the patient declined the recommended postoperative radiotherapy.
  • [MeSH-major] Ear Neoplasms / surgery. Histiocytoma, Benign Fibrous / surgery. Neoplasm Recurrence, Local / surgery. Parotid Neoplasms / secondary. Parotid Neoplasms / surgery

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  • (PMID = 18210006.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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19. Shaw CK, Sood S, Bradley PJ, Krishnan S: Unusual mass in the parapharyngeal space: a Warthin's tumour. ANZ J Surg; 2006 Mar;76(3):193-4
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  • [Title] Unusual mass in the parapharyngeal space: a Warthin's tumour.
  • Most of the PPS tumours are salivary tumours (pleomorphic adenoma being the most frequent diagnosis), and are thought to originate from minor salivary glands or the deep lobe of the parotid gland.
  • Warthin's tumour, another benign salivary tumour involving the PPS has been rarely reported.
  • A case of bilateral, metachronous Warthin's tumour involving the PPS is reported here.
  • PPS Warthin's tumour is a very rare condition that if undiagnosed may result in considerable morbidity.
  • [MeSH-major] Adenolymphoma / pathology. Neoplasms, Second Primary / pathology. Parotid Neoplasms / pathology. Pharynx / pathology
  • [MeSH-minor] Aged. Female. Humans. Neoplasm Invasiveness. Parotid Gland / surgery. Tomography, X-Ray Computed

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  • (PMID = 16626365.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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20. Harimaya A, Somekawa Y, Sasaki M, Ohuchi T: Cystadenocarcinoma (papillary cystadenocarcinoma) of the submandibular gland. J Laryngol Otol; 2006 Dec;120(12):1077-80
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  • [Title] Cystadenocarcinoma (papillary cystadenocarcinoma) of the submandibular gland.
  • Cystadenocarcinoma (papillary cystadenocarcinoma) of the salivary gland is a rare malignant neoplasm.
  • Major locations of this neoplasm are the parotid gland, the sublingual gland, and minor salivary glands, while occurrence in the submandibular gland is extremely rare.
  • As far as we know, only one report, written in the French language, has been published concerning cystadenocarcinoma of the submandibular gland, but no report is available in the English language.
  • In this report, we describe a case of cystadenocarcinoma arising from the submandibular gland of a 54-year-old male patient.
  • The neoplasm is a low-grade carcinoma, and pre-operative examination may not show typical characteristics of malignant neoplasms.
  • Therefore, as was true in this case, the differential diagnosis from benign lesions is sometimes difficult.
  • This is the first report on cystadenocarcinoma of the submandibular gland in the English language and the first to show a computed tomography (CT) scan and magnetic resonance imaging (MRI) of this neoplasm in the submandibular gland.
  • [MeSH-major] Cystadenocarcinoma, Papillary / pathology. Submandibular Gland Neoplasms / pathology

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  • (PMID = 16995970.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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21. Aras HC, Ekström J: Cholecystokinin- and gastrin-induced protein and amylase secretion from the parotid gland of the anaesthetized rat. Regul Pept; 2006 May 15;134(2-3):89-96
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  • [Title] Cholecystokinin- and gastrin-induced protein and amylase secretion from the parotid gland of the anaesthetized rat.
  • I.V. infusion of pentagastrin (20 microg/kg/h) or cholecystokinin (CCK)-8 (1 microg/kg/h) for 10 min caused secretion of salivary proteins from the parotid gland in the anaesthetized rat without any accompanying overt fluid secretion.
  • In the submandibular gland, both pentagastrin and CCK-8 evoked a trace secretion of saliva but, under the present experimental set-up, no statistically significant increase in protein output.
  • Thus, in addition to the autonomic nervous system, gastrointestinal hormones may, in some types of glands, be involved in the secretion of salivary gland proteins.
  • [MeSH-major] Amylases / secretion. Parotid Gland / drug effects. Parotid Gland / secretion. Pentagastrin / pharmacology. Salivary Proteins and Peptides / secretion. Sincalide / pharmacology
  • [MeSH-minor] Anesthesia. Animals. Female. Gastrointestinal Tract / physiology. Methacholine Chloride / pharmacology. Parasympathectomy. Pentobarbital. Rats. Rats, Sprague-Dawley. Receptor, Cholecystokinin A / biosynthesis. Receptor, Cholecystokinin B / biosynthesis. Salivation / drug effects. Submandibular Gland / drug effects. Submandibular Gland / secretion. Sympathectomy

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  • (PMID = 16515811.001).
  • [ISSN] 0167-0115
  • [Journal-full-title] Regulatory peptides
  • [ISO-abbreviation] Regul. Pept.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Receptor, Cholecystokinin A; 0 / Receptor, Cholecystokinin B; 0 / Salivary Proteins and Peptides; 0W5ETF9M2K / Methacholine Chloride; EC 3.2.1.- / Amylases; EF0NX91490 / Pentagastrin; I4744080IR / Pentobarbital; M03GIQ7Z6P / Sincalide
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22. Roesink JM, Schipper M, Busschers W, Raaijmakers CP, Terhaard CH: A comparison of mean parotid gland dose with measures of parotid gland function after radiotherapy for head-and-neck cancer: implications for future trials. Int J Radiat Oncol Biol Phys; 2005 Nov 15;63(4):1006-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A comparison of mean parotid gland dose with measures of parotid gland function after radiotherapy for head-and-neck cancer: implications for future trials.
  • PURPOSE: To determine the most adequate parameter to measure the consequences of reducing the parotid gland dose.
  • Parotid gland function was objectively determined by measuring stimulated parotid flow using Lashley cups and scintigraphy.
  • The correlation between these complications and the mean parotid gland dose was investigated to find the best measure for parotid gland function.
  • RESULTS: For both flow and scintigraphy data, the best definition for objective parotid gland toxicity seemed to be reduction of stimulated parotid flow to < or =25% of the preradiotherapy flow.
  • The best correlation with the mean parotid gland dose was found for the stimulated flow measurements.
  • Subjective findings did not correlate with the mean parotid dose.
  • CONCLUSIONS: Stimulated flow measurements using Lashley cups, with a complication defined as flow < or =25% of the preradiotherapy output, correlated best with the mean parotid gland dose.
  • When reduction of the mean dose to the parotid gland is intended, the stimulated flow measurement is the best method for evaluating parotid gland function.
  • [MeSH-major] Head and Neck Neoplasms / radiotherapy. Parotid Gland / radiation effects. Salivation / radiation effects

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  • (PMID = 15964708.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Huang X, Sun W, Liu X, Liu W, Guan Z, Xu Y, Zheng Y: Endoscope-assisted partial-superficial parotidectomy through a concealed postauricular skin incision. Surg Endosc; 2009 Jul;23(7):1614-9
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  • METHODS: Endoscope-assisted partial-superficial parotidectomy through a concealed postauricular skin incision was performed for 18 cases of benign tumor located in the superficial lobe of the parotid gland.
  • CONCLUSIONS: Endoscope-assisted partial-superficial parotidectomy is a feasible method for treatment of benign tumors located in the superficial lobe of the parotid gland.
  • [MeSH-major] Adenolymphoma / surgery. Adenoma, Pleomorphic / surgery. Endoscopy / methods. Parotid Gland / surgery. Parotid Neoplasms / surgery

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  • (PMID = 19343432.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
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24. Mortensen KS, Hjortlund J, Bjørndal K, Krogdal A, Godballe C: [Salivary gland tumors in the County of Funen, 1984-2003]. Ugeskr Laeger; 2008 Feb 11;170(7):545-8
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  • [Title] [Salivary gland tumors in the County of Funen, 1984-2003].
  • INTRODUCTION: The objective of this study is to estimate the incidence of major salivary gland tumors in a geographically well-defined area (the County of Funen, Denmark) and to analyse the demographic data and distribution of histological types.
  • MATERIALS AND METHODS: Patients with salivary gland tumors were identified through a search on pathology and diagnosis codes in the period 1984-2003, which initially resulted in a group of 951 patients.
  • RESULTS: The incidence of major salivary gland tumors for the County of Funen is calculated to 7.3 per 100,000 residents per year.
  • 90% of the tumors were found in the parotid gland - 93% benign and 7% malignant.
  • 10% were located in the submandibular gland - 73% benign and 27% malignant.
  • Only one neoplasm was located in the sublingual gland and it was malignant (100%).
  • CONCLUSION: The incidence of major salivary gland tumors in the County of Funen is calculated to 7.3 per 100,000 inhabitants per year which is equivalent to 383 new cases in Denmark per year.
  • [MeSH-major] Adenolymphoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Salivary Gland Neoplasms / epidemiology

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  • (PMID = 18291086.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Denmark
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25. Touré G, Vacher C: Relations of the facial nerve with the retromandibular vein: anatomic study of 132 parotid glands. Surg Radiol Anat; 2010 Dec;32(10):957-61
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  • [Title] Relations of the facial nerve with the retromandibular vein: anatomic study of 132 parotid glands.
  • BACKGROUND: The retromandibular vein (rmv) is an important anatomical element, in radiology to localise a tumor in the parotid gland in relation to the facial nerve, and in surgery as a landmark to dissect the facial nerve and its branches.
  • METHODS: One hundred and thirty-two parotid glands have been dissected by pre-auricular route.
  • The situation of the rvm alone or associated with other anatomical elements is not a reliable landmark of the situation of a tumour either in the superficial part or in the deep part of the parotid gland in relation to the facial nerve.
  • [MeSH-major] Facial Nerve / anatomy & histology. Parotid Gland / anatomy & histology. Parotid Region / blood supply

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  • [Cites] Br J Plast Surg. 2002 Jul;55(5):376-9 [12372364.001]
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  • (PMID = 20473672.001).
  • [ISSN] 1279-8517
  • [Journal-full-title] Surgical and radiologic anatomy : SRA
  • [ISO-abbreviation] Surg Radiol Anat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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26. Van der Weijden GA, Ten Heggeler JM, Slot DE, Rosema NA, Van der Velden U: Parotid gland swelling following mouthrinse use. Int J Dent Hyg; 2010 Nov;8(4):276-9
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  • [Title] Parotid gland swelling following mouthrinse use.
  • BACKGROUND: Unilateral or bilateral swelling of the parotid gland is a reported side effect of rinsing the mouth with chlorhexidine.
  • METHODS: In this report, two cases of parotid gland swelling are discussed.
  • Both patients developed unilateral parotid swelling following the use of a mouthwash, case 1 after using a chlorhexidine mouthwash following flap surgery and case 2 after using a hexetidine mouthwash in an approved clinical trial that was testing different mouthwashes.
  • RESULTS: In both of the cases, differential diagnoses were made to explain the cause of the parotid swelling.
  • CONCLUSIONS: Swelling of the parotid gland following use of a mouthwash has previously been reported, although previous reports found this side effect only in patients who used chlorhexidine mouthwashes.
  • The present case report questions this hypothesis and suggests that parotid gland swelling may not be related to the type of mouthwash used, but may instead be a consequence of the rinsing action itself.
  • [MeSH-major] Anti-Infective Agents, Local / adverse effects. Chlorhexidine / adverse effects. Edema / chemically induced. Hexetidine / adverse effects. Mouthwashes / adverse effects. Parotid Diseases / chemically induced

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  • [Copyright] © 2009 The Authors. Journal compilation © 2009 Blackwell Munksgaard.
  • (PMID = 20961383.001).
  • [ISSN] 1601-5037
  • [Journal-full-title] International journal of dental hygiene
  • [ISO-abbreviation] Int J Dent Hyg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Infective Agents, Local; 0 / Mouthwashes; 852A84Y8LS / Hexetidine; R4KO0DY52L / Chlorhexidine
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27. Newton JR, O'Donnell M, Samuel PR: A case of renal cell carcinoma metastasizing to the parotid gland. Otolaryngol Head Neck Surg; 2007 Apr;136(4 Suppl):S65-7
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  • [Title] A case of renal cell carcinoma metastasizing to the parotid gland.
  • [MeSH-major] Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Parotid Neoplasms / secondary

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  • (PMID = 17398347.001).
  • [ISSN] 1097-6817
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Veillon F, Taboada LR, Eid MA, Riehm S, Debry C, Schultz P, Charpiot A: Pathology of the facial nerve. Neuroimaging Clin N Am; 2008 May;18(2):309-20, x
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  • In malignant tumors of the parotid gland, a study of the fallopian canal must always be performed to delineate an extension in the mastoid, tympanic, or intrameatic parts.

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  • (PMID = 18466834.001).
  • [ISSN] 1052-5149
  • [Journal-full-title] Neuroimaging clinics of North America
  • [ISO-abbreviation] Neuroimaging Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 17
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29. Roh JL: Extracapsular dissection of benign parotid tumors using a retroauricular hairline incision approach. Am J Surg; 2009 May;197(5):e53-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extracapsular dissection of benign parotid tumors using a retroauricular hairline incision approach.
  • Extracapsular dissection has emerged as a more conservative approach to parotid surgery.
  • The parotid surgery commonly begins with a modified Blair or facelift incision.
  • I initially developed a retroauricular hairline incision (RAHI) for the removal of benign lesions in the upper neck with a more esthetic look.
  • The RAHI approach also may be used for selected patients with benign parotid neoplasms.
  • Mobile benign tumors arising in the inferior superficial part of the parotid gland may be removed by the RAHI approach without compromising surgical visualization.
  • The RAHI without a preauricular incision is a feasible technique in the surgical management of parotid tumors.
  • [MeSH-major] Dissection / methods. Oral Surgical Procedures / methods. Parotid Neoplasms / surgery

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  • (PMID = 19217603.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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30. Taniyama Y, Suzuki T, Mikami Y, Moriya T, Satomi S, Sasano H: Systemic distribution of somatostatin receptor subtypes in human: an immunohistochemical study. Endocr J; 2005 Oct;52(5):605-11
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  • Among human tissues in which the presence of sstr has not been previously reported, the parotid gland demonstrated immunoreactivity for sstr2B and sstr5, bronchial gland for sstr1, 2B, 3, 4, 5, parathyroid gland for sstr1, 3, 4, and duodenum for all subtypes immunoreactivity.
  • In stomach, all subtypes of receptor were detected in various cell types of the mucosa, but none in ECL cells of fundic gland.

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  • (PMID = 16284440.001).
  • [ISSN] 0918-8959
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / Receptors, Somatostatin; 0 / somatostatin receptor 2; 0 / somatostatin receptor 3; 0 / somatostatin receptor 5; 0 / somatostatin receptor subtype-4; 0 / somatostatin receptor type 1
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31. Hirai T, Kimura S, Mori N: Head and neck infections caused by Streptococcus milleri group: an analysis of 17 cases. Auris Nasus Larynx; 2005 Mar;32(1):55-8
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  • The sites of infection were as follows: maxillary sinus (n=6), peritonsillar region (n=4), subcutaneous (n=3), submandibular space-retropharyngeal space (n=1), deep neck-mediastinum (n=1), parapharyngeal space (n=1), submandibular space (n=1), tonsil (n=1), parotid gland (n=1), and masseter muscle (n=1).
  • [MeSH-major] Mediastinal Diseases / microbiology. Paranasal Sinus Diseases / microbiology. Parotid Diseases / microbiology. Peritonsillar Abscess / microbiology. Streptococcal Infections / complications. Streptococcus milleri Group / isolation & purification. Submandibular Gland Diseases / microbiology

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  • (PMID = 15882827.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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32. Marchese-Ragona R, Marioni G, Restivo DA, Staffieri A: The role of botulinum toxin in postparotidectomy fistula treatment. A technical note. Am J Otolaryngol; 2006 May-Jun;27(3):221-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Parotid fistula is a well-known complication of parotidectomy or penetrating injury of the parotid gland.
  • The management of parotid fistula has been controversial, and numerous conservative and surgical treatment methods have been described.
  • METHODS: We report 3 cases of parotid fistula after partial parotidectomy, which were treated by botulinum toxin injection under electromyographic control into the residual substance of parotid gland.
  • CONCLUSIONS: In the considered cases, the localized injection of botulinum toxin into the parotid gland resulted to an effective and long-lasting treatment of postparotidectomy fistula.
  • [MeSH-major] Botulinum Toxins, Type A / therapeutic use. Parotid Diseases / drug therapy. Parotid Neoplasms / surgery. Postoperative Complications / drug therapy. Salivary Gland Fistula / drug therapy

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  • (PMID = 16647991.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.24.69 / Botulinum Toxins, Type A
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33. Lamovec J, Volavsek M: Sclerosing rhabdomyosarcoma of the parotid gland in an adult. Ann Diagn Pathol; 2009 Oct;13(5):334-8
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  • [Title] Sclerosing rhabdomyosarcoma of the parotid gland in an adult.
  • Primary rhabdomyosarcoma of salivary glands is an extremely rare neoplasm, mostly seen in children.
  • We report on a parotid gland tumor characterized by infiltrative growth of primitive type of neoplastic cells showing strong and diffuse nuclear positivity for MyoD1 and myogenin and by prominent hyalinized/chondroid matrix with some myxoid foci.
  • The tumor recurred several times, and in recurrent tumors, differentiation into strap myoid cells appeared.
  • To our knowledge, this is the first reported case of primary sclerosing rhabdomyosarcoma of the parotid gland.
  • [MeSH-major] MyoD Protein / metabolism. Parotid Neoplasms / pathology. Rhabdomyosarcoma / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cell Nucleus / metabolism. Cell Nucleus / pathology. Diagnosis, Differential. Disease-Free Survival. Fibrosarcoma / diagnosis. Humans. Male. Middle Aged. Sclerosis

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  • (PMID = 19751910.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MyoD Protein; 0 / MyoD1 myogenic differentiation protein
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34. Brook I: The bacteriology of salivary gland infections. Oral Maxillofac Surg Clin North Am; 2009 Aug;21(3):269-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The bacteriology of salivary gland infections.
  • The parotid gland is the salivary gland most commonly affected by inflammation.
  • [MeSH-minor] Anti-Bacterial Agents / therapeutic use. Bacteria / isolation & purification. Bacterial Typing Techniques. Humans. Parotitis / diagnosis. Parotitis / drug therapy. Parotitis / microbiology

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  • (PMID = 19608044.001).
  • [ISSN] 1558-1365
  • [Journal-full-title] Oral and maxillofacial surgery clinics of North America
  • [ISO-abbreviation] Oral Maxillofac Surg Clin North Am
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
  • [Number-of-references] 45
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35. Schmutzhard J, Schwentner IM, Andrle J, Gunkel AR, Sprinzl GM: Resection of accessory parotid gland tumors through a peroral approach with facial nerve monitoring. J Craniofac Surg; 2007 Nov;18(6):1419-21
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  • [Title] Resection of accessory parotid gland tumors through a peroral approach with facial nerve monitoring.
  • Accessory parotid glands are an anatomic variation.
  • Pathologic alterations, which occur in these tissues, are related to those found in the parotid gland.
  • We are confident that the peroral resection, supported by active and passive facial nerve monitoring, is a discussable alternative for well-selected tumors of accessory parotid glands.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Facial Nerve. Monitoring, Intraoperative. Oral Surgical Procedures / methods. Parotid Neoplasms / surgery

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  • (PMID = 17993893.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. Silva SJ, Costa Junior GT, Brant Filho AC, Faria PR, Loyola AM: Metachronous bilateral pleomorphic adenoma of the parotid gland. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Mar;101(3):333-8
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  • [Title] Metachronous bilateral pleomorphic adenoma of the parotid gland.
  • Bilateral salivary gland tumors are very rare, accounting for 3% of all parotid gland tumors.
  • Although the most common tumor with bilateral development is the Warthin tumor, pleomorphic adenomas (PA) have been diagnosed simultaneously as well, but in a smaller incidence.
  • We present a case of bilateral metachronous PA affecting the parotid gland in a 63-year-old woman.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Facial Nerve / surgery. Female. Humans. Middle Aged. Parotid Gland / surgery

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  • (PMID = 16504867.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 51
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37. Javkhlan P, Hiroshima Y, Azlina A, Hasegawa T, Yao C, Akamatsu T, Kido J, Nagata T, Hosoi K: Induction of calprotectin mRNAs by lipopolysaccharide in the salivary gland of mice. J Med Invest; 2009;56 Suppl:287-9
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  • [Title] Induction of calprotectin mRNAs by lipopolysaccharide in the salivary gland of mice.
  • Here we examined if the biological role of TLR receptor is reflected to the calprotectin expression in the salivary gland.
  • Time course study by using real-time RT-PCR detected higher levels of S100A8 and S100A9 mRNA at 1.5-3 h after injection of LPS in both the submandibular gland (SMG) and parotid gland (PG) of C3H/HeN mice but not in the same tissues of C3H/HeJ, a TLR-4 mutant strain, indicating that this induction is mediated via the TLR-4.
  • These results indicate that, an inflammatory marker, calprotectin, is expressed in the mouse salivary gland and that LPS stimulated its synthesis.
  • [MeSH-minor] Animals. Calgranulin A / genetics. Calgranulin A / metabolism. Calgranulin B / genetics. Calgranulin B / metabolism. Mice. Mice, Inbred C3H. Mice, Mutant Strains. Parotid Gland / drug effects. Parotid Gland / metabolism. Submandibular Gland / drug effects. Submandibular Gland / metabolism. Toll-Like Receptor 4 / genetics. Toll-Like Receptor 4 / metabolism

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  • (PMID = 20224205.001).
  • [ISSN] 1349-6867
  • [Journal-full-title] The journal of medical investigation : JMI
  • [ISO-abbreviation] J. Med. Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Calgranulin A; 0 / Calgranulin B; 0 / Leukocyte L1 Antigen Complex; 0 / Lipopolysaccharides; 0 / RNA, Messenger; 0 / Tlr4 protein, mouse; 0 / Toll-Like Receptor 4
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38. Salgarelli AC, Capparè P, Bellini P, Collini M: Usefulness of fine-needle aspiration in parotid diagnostics. Oral Maxillofac Surg; 2009 Dec;13(4):185-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Usefulness of fine-needle aspiration in parotid diagnostics.
  • Among head and neck sites, the parotid gland is unique in the number, diversity, and peculiarity of its pathological processes.
  • This complexity has prompted a great deal of discussion regarding the application of FNA to parotid masses, primarily focusing on the reliability of FNA as a diagnostic tool in guiding patient management.
  • METHODS: This review presents an analysis of the usefulness of FNA in differential diagnosis of parotid pathologies.
  • RESULTS: Recent studies have confirmed a wide range of accuracy rates for FNA evaluation of parotid masses, varying from 79% to 97%.
  • FNA is notoriously unreliable in recognising the malignant nature of parotid carcinoma providing its precise classification and establishing its grade.
  • A few malignant neoplasms are particularly prone to diagnostic error: acinic cell carcinoma is frequently interpreted as benign, and low-grade lymphomas are often discounted as inflammatory processes.
  • CONCLUSIONS: FNA cytology is useful in avoiding surgery (inflammatory lesions) or limiting surgical procedures (benign tumours).
  • For planning the extent of surgery of malignant parotid tumours, the histological subtype and/or grade should be determined; therefore, a histological diagnosis by frozen section analysis is required.
  • Regardless of whether FNA is used routinely or selectively in patients with parotid masses, the findings should contribute to, and not replace, the overall diagnostic impression.
  • [MeSH-major] Biopsy, Fine-Needle. Parotid Diseases / pathology. Parotid Neoplasms / pathology

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  • (PMID = 19821124.001).
  • [ISSN] 1865-1569
  • [Journal-full-title] Oral and maxillofacial surgery
  • [ISO-abbreviation] Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 51
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39. Issy AC, da Silva CA, Guimarães FS, Del Bel EA: Different role of isoproterenol and NOS inhibitors on salivary ducts of rats. Micron; 2009 Apr;40(3):343-9
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  • Chronic treatment with isoproterenol, a beta receptor agonist, stimulates the release of NO from acinar cells and induces salivary gland hypertrophy.
  • We analyzed salivary gland weight and the number of ducts per unit area (0.5mm(2)) by NADPH-diaphorase histochemistry (to identify the presence of the enzyme NO synthase-NOS) and haematoxylin-and-eosin (HE).
  • RESULTS: Isoproterenol increased parotid and submandibular gland weights.
  • Isoproterenol (2mg/kg) induced a decrease of ducts per unit area inversely correlated to the weight of the parotid gland.
  • In the submandibular gland L-NAME attenuated isoproterenol (2mg/kg) weight increase.
  • In the submandibular gland isoproterenol and NOS inhibitors induced an increase in ducts per unit area (HE and NADPH-diaphorase).
  • No effect was observed in the sublingual gland.
  • CONCLUSION: To our knowledge this is the first description of isoproterenol and NOS inhibitors increasing duct density in the submandibular gland.
  • Our results corroborate the hypothesis that NO plays different roles in parotid and submandibular glands.
  • [MeSH-minor] Animals. Enzyme Inhibitors / administration & dosage. Injections, Intraperitoneal. Injections, Subcutaneous. Male. NG-Nitroarginine Methyl Ester / administration & dosage. Nitric Oxide / metabolism. Nitric Oxide Synthase / antagonists & inhibitors. Parotid Gland / cytology. Parotid Gland / drug effects. Parotid Gland / metabolism. Rats. Rats, Inbred BB. Sublingual Gland / cytology. Sublingual Gland / drug effects. Sublingual Gland / metabolism. Submandibular Gland / cytology. Submandibular Gland / drug effects. Submandibular Gland / metabolism

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  • (PMID = 19167231.001).
  • [ISSN] 0968-4328
  • [Journal-full-title] Micron (Oxford, England : 1993)
  • [ISO-abbreviation] Micron
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adrenergic beta-Agonists; 0 / Enzyme Inhibitors; 2149-70-4 / Nitroarginine; 31C4KY9ESH / Nitric Oxide; EC 1.14.13.39 / Nitric Oxide Synthase; L628TT009W / Isoproterenol; V55S2QJN2X / NG-Nitroarginine Methyl Ester
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40. Kim DI, Nam SH, Nam YS, Lee KS, Chung RH, Han SH: The marginal mandibular branch of the facial nerve in Koreans. Clin Anat; 2009 Mar;22(2):207-14
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  • The MMB showed one (28%), two (52%), three (18%), or four branches (2%) where it exited the parotid gland.
  • [MeSH-minor] Aged. Female. Humans. Korea. Male. Parotid Gland / innervation

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  • [Copyright] Copyright 2008 Wiley-Liss, Inc.
  • (PMID = 19089998.001).
  • [ISSN] 1098-2353
  • [Journal-full-title] Clinical anatomy (New York, N.Y.)
  • [ISO-abbreviation] Clin Anat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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41. Srivastava A, Romanenko VG, Gonzalez-Begne M, Catalán MA, Melvin JE: A variant of the Ca2+-activated Cl channel Best3 is expressed in mouse exocrine glands. J Membr Biol; 2008 Mar;222(1):43-54
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  • The parotid gland and heart expressed proteins of the predicted size for Best3-Delta2,3,6 and full-length Best3, respectively, that targeted to the plasma membrane in HEK293 cells.
  • Cotransfection of Best3-Delta2,3,6 with Best3 or Best2 (also expressed in salivary gland acinar cells) had no significant effects on the currents generated by either of these Ca2+-dependent Cl channels.

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  • (PMID = 18414923.001).
  • [ISSN] 0022-2631
  • [Journal-full-title] The Journal of membrane biology
  • [ISO-abbreviation] J. Membr. Biol.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / DE08921; United States / NIDCR NIH HHS / DE / DE09692
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Best2 protein, mouse; 0 / Chloride Channels; 0 / Eye Proteins; 0 / Ion Channels; 0 / Vmd2 protein, mouse
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42. Debnath SC, Saikia A: Lipoma of the parotid gland extending from the superficial to the deep lobe: a rarity. Br J Oral Maxillofac Surg; 2010 Apr;48(3):203-4
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  • [Title] Lipoma of the parotid gland extending from the superficial to the deep lobe: a rarity.
  • Lipoma of the parotid gland is a rare clinical entity.
  • Because of the rarity, they are not often considered in the differential diagnosis of parotid tumors.
  • Lipoma of the parotid gland constitutes around 3% of all parotid tumors.
  • These are asymptomatic and occur both in the deep and the superficial lobe of the parotid.(1) The most favored age group is from the fifth to sixth decade of life and is 10 times more common in the males.(6) Lipoma extending from superficial to deep lobe of parotid gland has not been reported in the literature to our knowledge till date.
  • A 56-year-old male patient, with this relatively rare parotid gland lipoma is reported in this article; it was managed by conservative superficial parotidectomy preserving facial nerve that, if performed correctly, excludes the possibility of any second attack.
  • [MeSH-major] Lipoma / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adipose Tissue / pathology. Connective Tissue / pathology. Follow-Up Studies. Humans. Male. Middle Aged. Parotid Gland / pathology

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  • [Copyright] 2009 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 19910088.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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43. Kierzek A: [Julian Kosiński (1833-1914)--especially meritorious surgeon for the development of otorhinolaryngology. His achievements in therapy of ear, nose, throat and borderland diseases]. Otolaryngol Pol; 2008;62(2):223-30
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  • Kosiński's successful surgical treatment of otorhinopharyngeal diseases and the borderland (such as auricle's fibroma, keloid and periauricular atheroma, carcinomas of nasi and other parts of face, sarcomas of nasopharyngeal cavity and pharynx and maxillary sinus, syphilis of face, tuberculous ulceration of tongue, osteomas of palate and pharynx, foreign bodies of oesophagus, inflammations of parotid gland and other) are described in some more detail.

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  • (PMID = 18637452.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Biography; English Abstract; Historical Article; Journal Article; Portraits
  • [Publication-country] Poland
  • [Personal-name-as-subject] Kosiński J
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44. Ijichi K, Hasegawa Y, Ogawa T, Terada A, Hyodo I, Yamada H, Murakami S: [Investigation for cervical lymph node metastasis in unknown primary sites]. Nihon Jibiinkoka Gakkai Kaiho; 2005 Nov;108(11):1083-90
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  • In patients with cervical adenopathy, especially, those of cervical lymph node metastasis with no detectable primary tumor, diagnosis and treatment planning can become confused.
  • Primary sites were 5 cases of oropharynx, 2 of the parotid gland, and 1 each of larynx, nasopharynx, hypopharynx, and malignant lymphoma detected in 11 after treatment for cervical lymph nodes.

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  • (PMID = 16359003.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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45. Bouilloud F, Jégoux F, Caze A, Godey B, Le Clech G: [Parapharyngeal tumors: diagnosis and treatment]. Ann Otolaryngol Chir Cervicofac; 2008 Sep;125(4):181-7
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  • [Title] [Parapharyngeal tumors: diagnosis and treatment].
  • OBJECTIVES: Parapharyngeal space tumors are rare and usually benign.
  • Two retrostyloid tumors and six prestyloid tumors, all independent of the deep lobe of the parotid gland, were found.
  • They were benign in all cases (five salivary tumors and four schwannomas).
  • CONCLUSION: The cervical approach is safe and allows the surgical excision of retrostyloid and prestyloid tumors, independent of the deep lobe of the parotid gland.
  • Large tumor (8cm in our study) excision can be done with few complications.
  • [MeSH-major] Pharyngeal Neoplasms / diagnosis. Pharyngeal Neoplasms / surgery

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  • (PMID = 18678362.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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46. Nouraei SA, Al-Yaghchi C, Ahmed J, Kirkpatrick N, Mansuri S, Singh A, Grant WE: An anatomical comparison of Blair and facelift incisions for parotid surgery. Clin Otolaryngol; 2006 Dec;31(6):531-4
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  • [Title] An anatomical comparison of Blair and facelift incisions for parotid surgery.
  • The technique has gained popularity particularly with plastic surgeons, but concerns persist that with this approach, particularly with lesions located anteriorly, access to the gland may be inadequate, and facial nerve identification may be compromised.
  • MATERIALS AND METHODS: We undertook an anatomical study to quantitatively compare the surgical access achieved using the facelift approach with the conventional Blair incision, by comparing the distances between the parotid edge and the retracted flaps.
  • RESULTS: Despite reduced tissue elasticity due to formaldehyde fixation, it proved possible to demonstrate all regions of the parotid gland to the operating surgeon with either approach.
  • There were no significant differences in the distance between the parotid edge and the retracted skin flaps (P > 0.1; paired t-test).
  • CONCLUSIONS: The facelift approach provides at least equal access to all regions of the parotid gland when compared to a Blair's incision.
  • It is a superior approach aesthetically and its more widespread use in parotid surgery is advocated.
  • [MeSH-major] Parotid Gland / anatomy & histology. Parotid Gland / surgery. Surgical Flaps. Suture Techniques
  • [MeSH-minor] Adenoma, Pleomorphic / surgery. Cadaver. Humans. Parotid Neoplasms / surgery. Rhytidoplasty

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  • (PMID = 17184460.001).
  • [ISSN] 1749-4478
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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47. Choi KM: Reemergence of mumps. Korean J Pediatr; 2010 May;53(5):623-8
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  • Mumps is characterized by bilateral or unilateral swelling of the parotid gland.
  • Diagnosis is based on clinical findings, but because of high vaccination coverage, clinical findings alone are not sufficient for diagnosis, and laboratory confirmation is needed.
  • In this review, we investigate the reason for the epidemics, optimal methods of diagnosis, and surveillance of immunization status for the prevention of future epidemics.

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  • (PMID = 21189927.001).
  • [ISSN] 2092-7258
  • [Journal-full-title] Korean journal of pediatrics
  • [ISO-abbreviation] Korean J Pediatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2994117
  • [Keywords] NOTNLM ; Mumps / Outbreak / Vaccination
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48. Barzilai G, Greenberg E, Cohen-Kerem R, Doweck I: Pattern of regional metastases from cutaneous squamous cell carcinoma of the head and neck. Otolaryngol Head Neck Surg; 2005 Jun;132(6):852-6
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  • RESULTS: Metastases could be assessed clinically in the parotid gland and the neck in 50% and 59% of the patients, respectively.
  • Histologic examination showed metastases in the parotid gland and the neck in 68% and 45.5%, respectively.
  • Occult disease was 36% and 20% in the parotid gland and neck, respectively.
  • The 1st echelon for metastasis was the parotid gland lymph nodes, whereas level II lymph nodes were the 1st echelon in the neck.
  • Metastases to both the parotid gland and neck decreased the overall survival to 0, compared with 60% for metastases to the parotid gland and 100% for the neck.
  • CONCLUSIONS: SCC of the skin of the head and neck with regional metastases has a high incidence of occult metastases in the parotid gland and the neck.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Head and Neck Neoplasms / pathology. Parotid Neoplasms / secondary. Skin Neoplasms / pathology


49. Mestiri S, Sriha B, Ziadi S, Trabelsi A, Trimeche M, Bouzaiene M, Korbi S: [Salivary duct carcinoma]. Rev Stomatol Chir Maxillofac; 2006 Nov;107(5):386-8
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  • INTRODUCTION: Salivary duct carcinoma is a very rare tumor of the salivary glands that has been principally reported in the parotid gland.
  • OBSERVATION: We report the case of a salivary duct carcinoma arising in the parotid gland of a 62 year-old man.
  • The fact that the tumor was confined to the parotid gland has allowed a radical treatment.
  • DISCUSSION: This tumor is characterized clinically by local aggressiveness, frequent metastatic evolution and poor prognosis.
  • [MeSH-major] Carcinoma / diagnosis. Parotid Neoplasms / diagnosis. Salivary Ducts / pathology
  • [MeSH-minor] Humans. Male. Middle Aged. Neoplasm Invasiveness. Tomography, X-Ray Computed

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  • (PMID = 17128193.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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50. Daboin KP, Ochoa-Perez V, Luna MA: Adenolipomas of the head and neck: analysis of 6 cases. Ann Diagn Pathol; 2006 Apr;10(2):72-6
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  • Adenolipomas are rare benign neoplasms composed of mature adipose tissue and glandular elements.
  • We report 6 patients with adenolipomas of the head and neck region: 3 in the parathyroid, 2 in the thyroid, and 1 in the parotid gland.
  • Computed tomography and magnetic resonance imaging are useful tools for the preoperative diagnosis of adenolipomas of the head and neck.
  • The findings of adipose tissue and benign glandular elements by fine-needle aspiration biopsy should prompt consideration of adenolipoma in the differential diagnosis.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Lipoma / diagnosis. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Parathyroid Glands / pathology. Parotid Gland / pathology

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  • [CommentIn] Ann Diagn Pathol. 2007 Oct;11(5):390; author reply 390-1 [17870027.001]
  • (PMID = 16546040.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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51. Aslan S, Yavuz H, Altan-Yaycioglu R, Bolat F, Ozgirgin N: Epidermoid carcinoma involving the parotid gland and orbital region: case report of a rare entity. Ear Nose Throat J; 2008 Jul;87(7):394-8
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  • [Title] Epidermoid carcinoma involving the parotid gland and orbital region: case report of a rare entity.
  • Epidermoid carcinoma (also known as squamous cell carcinoma) of the parotid gland is more prevalent among the elderly, as are other head and neck tumors.
  • In most cases it is observed either as a nodal metastasis of a primary tumor that drains into the parotid area or as a direct extension of a tumor that has originated in the upper dermis.
  • Primary epidermoid carcinomas arising directly from the parotid gland are extremely rare.
  • Similarly, secondary invasion of the orbital region by a neighboring tumor is more common than primary epidermoid carcinoma of the orbit, which is also rare.
  • In this article, we discuss the diagnosis and treatment of a rare case of epidermoid carcinoma simultaneously invading the parotid gland and the orbit.
  • [MeSH-major] Carcinoma, Squamous Cell. Orbital Neoplasms. Parotid Neoplasms

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  • (PMID = 18633934.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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52. Hwang K, Nam YS, Kim DJ, Han SH: Anatomy of tympanoparotid fascia relating to neck lift. J Craniofac Surg; 2008 May;19(3):648-51
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  • Two thirds of TRF originated from the tympanomastoid fissure and one third from the auricular cartilage and interfused with the parotid fascia, covering the parotid gland in front of the tragus.
  • It is significantly stronger (P=0.00) than the central portion of the parotid fascia (22.7+/-12.2 N).
  • [MeSH-major] Fascia / anatomy & histology. Neck / surgery. Parotid Region / anatomy & histology. Reconstructive Surgical Procedures

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  • (PMID = 18520378.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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53. Konings AW, Coppes RP, Vissink A: On the mechanism of salivary gland radiosensitivity. Int J Radiat Oncol Biol Phys; 2005 Jul 15;62(4):1187-94
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  • [Title] On the mechanism of salivary gland radiosensitivity.
  • METHODS AND MATERIALS: Selected published data on the mechanism of salivary gland radiosensitivity and radioprotection were studied and analyzed.
  • Although the cellular composition of the submandibular gland and the parotid gland are different, the damage response is very alike.
  • Later damage is mainly due to classical mitotic cell death of progenitor cells, leading to a hampered replacement capacity of the gland for secretory cells, but is also caused by damage to the extracellular environment, preventing proper cell functioning.
  • [MeSH-minor] Animals. Cell Membrane / radiation effects. Head and Neck Neoplasms / radiotherapy. Parotid Gland / radiation effects. Rats

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  • [ErratumIn] Int J Radiat Oncol Biol Phys. 2006 Jan 1;64(1):330
  • (PMID = 15990024.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 57
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54. Vogt A, Roser M, Weingart D: [Transparotidean approach to surgical management of condylar neck fractures. A prospective study]. Mund Kiefer Gesichtschir; 2005 Jul;9(4):246-50
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  • At the beginning of the study, in four cases a fistula of the parotid gland was seen within the initial days after surgery; after careful wound closure of the parotid capsula in the following operations, no further complications involving fistulas were observed.
  • [MeSH-major] Mandibular Condyle / injuries. Mandibular Fractures / surgery. Parotid Gland / surgery

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  • [Cites] Fortschr Kiefer Gesichtschir. 1980;25:84-91 [6936374.001]
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  • (PMID = 15988612.001).
  • [ISSN] 1432-9417
  • [Journal-full-title] Mund-, Kiefer- und Gesichtschirurgie : MKG
  • [ISO-abbreviation] Mund Kiefer Gesichtschir
  • [Language] ger
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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55. Al Bisher H: A rare case of primary tuberculosis infection with concurrent pleomorphic adenoma of the parotid gland. Infect Dis Rep; 2010 Feb 3;2(1):e6
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  • [Title] A rare case of primary tuberculosis infection with concurrent pleomorphic adenoma of the parotid gland.
  • Coexistence of parotid tuberculosis along with a benign parotid tumor is a rare entity with only nine cases reported in the literature.
  • We report here a case of primary parotid tuberculosis with concurrent pleomorphic adenoma in a 51-year-old female.

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  • (PMID = 24470888.001).
  • [ISSN] 2036-7430
  • [Journal-full-title] Infectious disease reports
  • [ISO-abbreviation] Infect Dis Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC3892577
  • [Keywords] NOTNLM ; parotid gland. / pleomorphic adenoma / primary tuberculosis
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56. Lee YY, Wong KT, King AD, Ahuja AT: Imaging of salivary gland tumours. Eur J Radiol; 2008 Jun;66(3):419-36
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imaging of salivary gland tumours.
  • Salivary gland neoplasms account for <3% of all tumors.
  • Most of them are benign and parotid gland is the commonest site.
  • As a general rule, the smaller the involved salivary gland, the higher is the possibility of the tumor being malignant.
  • The role of imaging in assessment of salivary gland tumour is to define intra-glandular vs. extra-glandular location, detect malignant features, assess local extension and invasion, detect nodal metastases and systemic involvement.
  • For lesions in the superficial parotid and submandibular gland, ultrasound is an ideal tool for initial assessment.
  • If deep tissue extension is suspected or malignancy confirmed on cytology, an MRI or CT is mandatory to evaluate tumour extent, local invasion and perineural spread.
  • For all tumours in the sublingual gland, MRI should be performed as the risk of malignancy is high.
  • For lesions of the deep lobe of parotid gland and the minor salivary glands, MRI and CT are the modalities of choice.
  • Ultrasound has limited visualization of the deep lobe of parotid gland which is obscured by the mandible.
  • Minor salivary gland lesions in the mucosa of oral cavity, pharynx and tracheo-bronchial tree, are also not accessible by conventional ultrasound.
  • Recent study suggests that MR spectroscopy may differentiate malignant and benign salivary gland tumours as well as distinguishing Warthin's tumor from pleomorphic adenoma.
  • Similarly, the role of nuclear medicine and PET scan, in imaging of parotid masses is limited.
  • Sialography is used to delineate the salivary ductal system and has limited role in assessment of tumour extent.
  • [MeSH-major] Diagnostic Imaging. Salivary Gland Neoplasms / diagnosis

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  • (PMID = 18337041.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 44
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57. Liao QL, Li LH, Lai RQ, Chen XD, Chen JW, Zhou YM: [Clinical and pathologic features of malignant myoepithelioma of salivary glands]. Zhonghua Bing Li Xue Za Zhi; 2005 Apr;34(4):211-4
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  • The tumor occurred predominantly in the parotid gland and minor salivary gland of the palate.
  • Common clinical features included sudden and rapid tumor growth, superficial ulceration, bony destruction and nerve infiltration.
  • Most tumors infiltrated adjacent normal salivary gland, adipose, muscular and bony tissues.
  • The tumor cells were atypical and demonstrated high mitotic activity.
  • In this study, 9 cases were composed predominantly of clear tumor cells.
  • Immunohistochemically the tumor cells were positive for CK, EMA, MSA, desmin and S-100 protein.
  • CONCLUSIONS: In general, MME is a rare and low-grade malignant salivary gland tumor.
  • Morphologic diagnosis of MME can be difficult in view of the wide spectrum of histologic changes.
  • A definitive diagnosis however is possible with the application of immunohistochemistry.
  • [MeSH-major] Myoepithelioma / pathology. Parotid Neoplasms / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Cytokines / metabolism. Desmin / metabolism. Diagnosis, Differential. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Salivary Glands, Minor / pathology


58. O'Daniel JC, Garden AS, Schwartz DL, Wang H, Ang KK, Ahamad A, Rosenthal DI, Morrison WH, Asper JA, Zhang L, Tung SM, Mohan R, Dong L: Parotid gland dose in intensity-modulated radiotherapy for head and neck cancer: is what you plan what you get? Int J Radiat Oncol Biol Phys; 2007 Nov 15;69(4):1290-6
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  • [Title] Parotid gland dose in intensity-modulated radiotherapy for head and neck cancer: is what you plan what you get?
  • PURPOSE: To quantify the differences between planned and delivered parotid gland and target doses, and to assess the benefits of daily bone alignment for head and neck cancer patients treated with intensity-modulated radiotherapy (IMRT).
  • RESULTS: Using conventional BB alignment led to increases in the parotid gland mean dose above the planned dose by 5 to 7 Gy in 45% of the patients (median, 3.0 Gy ipsilateral, p = 0.026; median, 1.0 Gy contralateral, p = 0.016).
  • However, the parotid dose from bone alignment was still greater than planned (median, 1.0 Gy, p = 0.007).
  • Neither approach affected tumor dose coverage.
  • CONCLUSIONS: With conventional BB alignment, the parotid gland mean dose was significantly increased above the planned mean dose.
  • Using daily bone alignment reduced the parotid dose compared with BB alignment in almost all patients.
  • A 3- to 4-mm planning margin was adequate for tumor dose coverage.

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  • (PMID = 17967319.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA074043-10; United States / NCI NIH HHS / CA / R01 CA074043; United States / NCI NIH HHS / CA / CA74043; United States / NCI NIH HHS / CA / R01 CA074043-10
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS33819; NLM/ PMC2288571
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59. Alibek S, Zenk J, Bozzato A, Lell M, Grunewald M, Anders K, Rabe C, Iro H, Bautz W, Greess H: The value of dynamic MRI studies in parotid tumors. Acad Radiol; 2007 Jun;14(6):701-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The value of dynamic MRI studies in parotid tumors.
  • RATIONALE AND OBJECTIVES: To evaluate the ability of dynamic contrast-enhanced magnetic resonance imaging (MRI) to differentiate several tumor entities of the parotid gland in a prospective clinical trial.
  • MATERIALS AND METHODS: A total of 112 patients with parotid tumors were examined with dynamic contrast-enhanced 1.5 T MRI.
  • Finally, all MRIs together with the tumor specific SIvT curves were re-read and correlated with histopathologic diagnosis.
  • CONCLUSIONS: With additional dynamic contrast-enhanced MRI, a more reliable differentiation between common parotid tumors is possible before surgery.
  • [MeSH-major] Adenolymphoma / diagnosis. Adenoma, Pleomorphic / diagnosis. Carcinoma / diagnosis. Magnetic Resonance Imaging / methods. Parotid Gland / pathology. Parotid Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Contrast Media / administration & dosage. Diagnosis, Differential. Female. Gadolinium. Humans. Image Enhancement / methods. Male. Middle Aged. Observer Variation. Predictive Value of Tests. Prospective Studies. Sensitivity and Specificity

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  • (PMID = 17502260.001).
  • [ISSN] 1076-6332
  • [Journal-full-title] Academic radiology
  • [ISO-abbreviation] Acad Radiol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; AU0V1LM3JT / Gadolinium
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60. Dangore-Khasbage SB, Degwekar SS, Bhowate RR, Bhake A: Metastatic involvement of parotid from carcinoma of the breast--a case report. Oral Maxillofac Surg; 2009 Mar;13(1):49-53
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  • [Title] Metastatic involvement of parotid from carcinoma of the breast--a case report.
  • INTRODUCTION: Involvement of parotid gland by metastases from distant primary malignant tumors is rare.
  • CASE REPORT: A 42-year-old female having right breast cancer had reported to the Department of Oral Diagnosis and Medicine with a chief complaint of a swelling in the left parotid gland region for 2 months.
  • On the basis of clinical findings, the primary malignancy of parotid gland was provisionally suspected.
  • DISCUSSION: Microscopic examination of parotid and breast revealed that parotid gland was involved as a distant metastases from a breast carcinoma, indicating that a swelling in the parotid needs to be assessed and investigated very carefully.
  • [MeSH-major] Breast Neoplasms / surgery. Carcinoma, Ductal, Breast / secondary. Carcinoma, Ductal, Breast / surgery. Parotid Neoplasms / secondary. Parotid Neoplasms / surgery
  • [MeSH-minor] Adult. Biopsy. Breast / pathology. Diagnosis, Differential. Female. Humans. India. Neck Dissection. Parotid Gland / pathology. Parotid Gland / surgery

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  • (PMID = 19190940.001).
  • [ISSN] 1865-1569
  • [Journal-full-title] Oral and maxillofacial surgery
  • [ISO-abbreviation] Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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61. Smolka W, Eggensperger N, Stauffer-Brauch EJ, von Bredow F, Lizuka T: Pleomorphic adenoma in an atypical location near the temporomandibular joint: a case report. Quintessence Int; 2007 May;38(5):417-21
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  • Pleomorphic adenomas primarily arise in the major salivary glands, especially in the parotid.
  • The tumor was solitary, closely attached to the capsule of the TMJ and superior to the parotid gland, with clear demarcation.
  • Clinically, the tumor resembled TMJ pathology, but MRI examination led to diagnosis of a benign tumor attached to the TMJ.
  • This report shows that pleomorphic adenoma can be a possible diagnosis for lesions at the joint capsule.
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male

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  • (PMID = 17568841.001).
  • [ISSN] 1936-7163
  • [Journal-full-title] Quintessence international (Berlin, Germany : 1985)
  • [ISO-abbreviation] Quintessence Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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62. Orita Y, Hamaya K, Miki K, Sugaya A, Hirai M, Nakai K, Nose S, Yoshino T: Satellite tumors surrounding primary pleomorphic adenomas of the parotid gland. Eur Arch Otorhinolaryngol; 2010 May;267(5):801-6
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  • [Title] Satellite tumors surrounding primary pleomorphic adenomas of the parotid gland.
  • The occasional local recurrence of benign pleomorphic adenoma (PA) has generally been attributed to the vulnerability of the tumor capsule.
  • A total of 108 specimens of primary parotid gland PA resected at the Okayama Saiseikai General Hospital from 1988 to 2008 were microscopically reviewed.
  • Four (3.7%) patients displayed a main mass with satellite tumors in a single parotid gland.
  • Satellite tumors surrounding the main mass of parotid PA is relatively rare.
  • In most cases, such satellite tumors will arise from capsular perforation of the primary tumor cells.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Neoplasms, Second Primary / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Genes, p53 / genetics. Humans. Immunohistochemistry. Infant. Infant, Newborn. Ki-67 Antigen / genetics. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local. Point Mutation / genetics. Preoperative Care

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  • (PMID = 19898859.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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63. Klintworth N, Zenk J, Koch M, Iro H: Postoperative complications after extracapsular dissection of benign parotid lesions with particular reference to facial nerve function. Laryngoscope; 2010 Mar;120(3):484-90
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  • [Title] Postoperative complications after extracapsular dissection of benign parotid lesions with particular reference to facial nerve function.
  • OBJECTIVES/HYPOTHESIS: The desirable extent of surgical intervention for benign parotid tumors remains a matter of controversy.
  • For some time now, extracapsular dissection without exposure of the main trunk of the facial nerve has been favored as an alternative for the treatment of discrete parotid tumors.
  • METHODS: We performed a retrospective analysis of the data from patients in whom extracapsular dissection of a benign parotid tumor had been performed under facial nerve monitoring and as a primary intervention in our department between 2000 and 2008.
  • RESULTS: A total of 934 patients were operated on for a newly diagnosed benign tumor of the parotid gland.
  • CONCLUSIONS: Extracapsular dissection of benign parotid tumors is associated with a low rate of postoperative complications, a fact that is confirmed by the available literature.
  • We therefore recommend that use of this technique always be considered as a means of treating benign parotid tumors as conservatively, that is, as uninvasively, as possible.
  • [MeSH-major] Facial Nerve Injuries / epidemiology. Parotid Gland / surgery. Parotid Neoplasms / surgery. Postoperative Complications / epidemiology

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  • (PMID = 20112414.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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64. Altuna Mariezkurrena X, Gorostiaga Aznar F, Zulueta Lizaur A, Algaba Guimerá J: [Evaluation of the fine needle aspiration biopsy in the presurgical diagnosis of tumors of the parotid gland]. An Otorrinolaringol Ibero Am; 2006;33(5):495-503
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  • [Title] [Evaluation of the fine needle aspiration biopsy in the presurgical diagnosis of tumors of the parotid gland].
  • [Transliterated title] Evaluación de la punción-aspiración con aguja fina (PAAF) como prueba prequirúrgica en las tumoraciones de glándula parótida.
  • We have also calculated the utility of clinical examination and radiology in the assessment of parotid masses.
  • [MeSH-major] Parotid Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Diagnosis, Differential. Evaluation Studies as Topic. Female. Humans. Male. Middle Aged. Parotid Gland / pathology. Parotid Gland / surgery. Preoperative Care. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 17091863.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Spain
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65. Aras HC, Ekström J: Melatonin-evoked in vivo secretion of protein and amylase from the parotid gland of the anaesthetised rat. J Pineal Res; 2008 Nov;45(4):413-21
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  • [Title] Melatonin-evoked in vivo secretion of protein and amylase from the parotid gland of the anaesthetised rat.
  • The intravenous infusion of melatonin (5 and 25 mg/kg over 10 min) evoked a dose-dependent output of protein and amylase but no overt fluid secretion from the parotid gland of the pentobarbitone-anaesthetised rat, as revealed by increased concentrations of protein and amylase activity in a subsequent wash-out flow of saliva in response to an intravenous bolus injection of methacholine (5 microg/kg) 10 min later.
  • They were not affected by the cholecystokinin A-receptor antagonist, lorglumide, and they were reproduced in eviscerated animals acutely subjected to postganglionic sympathetic and parasympathetic denervation of the gland.
  • Immunoblotting showed both melatonin receptors of type 1 and type 2 to be expressed in parotid gland tissue.
  • The results favour a direct action by melatonin on melatonin receptors of parotid secretory cells and suggest a potential physiological role for melatonin in the regulation of salivary glandular activities.
  • [MeSH-major] Amylases / secretion. Melatonin / physiology. Parotid Gland / secretion. Salivary Proteins and Peptides / secretion

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  • (PMID = 18637985.001).
  • [ISSN] 1600-079X
  • [Journal-full-title] Journal of pineal research
  • [ISO-abbreviation] J. Pineal Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Receptors, Melatonin; 0 / Salivary Proteins and Peptides; 0 / Tryptamines; 0W5ETF9M2K / Methacholine Chloride; 117946-91-5 / luzindole; EC 1.14.13.39 / Nitric Oxide Synthase; EC 3.2.1.- / Amylases; EPL8W5565D / Proglumide; I4744080IR / Pentobarbital; JL5DK93RCL / Melatonin; LAD1UQ73BE / lorglumide
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66. Hakim SG, Kosmehl H, Lauer I, Nadrowitz R, Wedel T, Sieg P: A comparative study on the protection profile of lidocaine, amifostine, and pilocarpin on the parotid gland during radiotherapy. Cancer Res; 2005 Nov 15;65(22):10486-93
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  • [Title] A comparative study on the protection profile of lidocaine, amifostine, and pilocarpin on the parotid gland during radiotherapy.
  • The aim of this study was to evaluate the individual and the synergetic radioprotective effect of lidocaine, amifostine, and pilocarpin on the parotid gland.
  • One week before irradiation (15 Gy) and 72 hours as well as 1 month afterward, the parotid gland was investigated morphologically, sialoscintigraphically, and immunohistochemically with the use of tenascin-C and alpha smooth muscle actin.
  • Potential radioprotective agents show different effects on both morphology and function of the parotid gland.
  • [MeSH-major] Amifostine / pharmacology. Lidocaine / pharmacology. Parotid Gland / drug effects. Parotid Gland / radiation effects. Pilocarpine / pharmacology. Radiation-Protective Agents / pharmacology

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  • (PMID = 16288041.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Radiation-Protective Agents; 0 / Tenascin; 01MI4Q9DI3 / Pilocarpine; 98PI200987 / Lidocaine; M487QF2F4V / Amifostine
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67. Dawson LA, Biersack M, Lockwood G, Eisbruch A, Lawrence TS, Ten Haken RK: Use of principal component analysis to evaluate the partial organ tolerance of normal tissues to radiation. Int J Radiat Oncol Biol Phys; 2005 Jul 1;62(3):829-37
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  • Two data sets were evaluated with this approach: 90 parotid gland cDVHs (36 with complications) and 203 liver cDVHs (19 with complications).
  • RESULTS: Ninety-four percent and 80% of the variation in cDVH morphology was described with two PCs for the parotid gland and the liver data sets, respectively.
  • For the parotid gland, one cluster contained PCs from parotid gland cDVHs with complications, and the other primarily contained PCs from cDVHs without complications.
  • The first PC value, corresponding to a larger volume treated with 10-60 Gy (2 Gy per fraction), was more likely to be larger in parotid gland cDVHs associated with complications than those without complications.

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  • (PMID = 15936567.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA085684; United States / NCI NIH HHS / CA / R01 CA85684; United States / NCI NIH HHS / CA / R03-CA78165
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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68. Lin WN, Huang HC, Wu CC, Liao CT, Chen IH, Kan CJ, Huang SF: Analysis of acinic cell carcinoma of the parotid gland - 15 years experience. Acta Otolaryngol; 2010 Dec;130(12):1406-10
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  • [Title] Analysis of acinic cell carcinoma of the parotid gland - 15 years experience.
  • CONCLUSION: In our experience, the prognosis for parotid gland acinic cell carcinoma (AciCC) is good.
  • Surgery alone would be sufficient in early-stage tumor.
  • OBJECTIVES: AciCC is a rare tumor in parotid gland malignancy.
  • RESULTS: Thirteen male and 12 female patients ranged in age from 16 to 84 years (mean 37.5 years) at the time of diagnosis.
  • The tumor stage distributions of the patients were 24%, 44%, 28%, and 4% for stages I, II, III, and IV, respectively.
  • [MeSH-major] Carcinoma, Acinar Cell / surgery. Parotid Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Disease-Free Survival. Dose Fractionation. Female. Follow-Up Studies. Humans. Lymphatic Irradiation. Male. Middle Aged. Neoplasm Staging. Parotid Gland / pathology. Parotid Gland / surgery. Prognosis. Radiotherapy, Adjuvant. Retrospective Studies. Young Adult

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  • (PMID = 20809887.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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69. Sabir Husin Athar PP, Yahya Z, Mat Baki M, Abdullah A: Facial nerve paralysis: a rare complication of parotid abscess. Malays J Med Sci; 2009 Apr;16(2):38-9
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  • [Title] Facial nerve paralysis: a rare complication of parotid abscess.
  • Benign parotid neoplasm and inflammatory processes of the parotid resulting in facial paralysis are extremely rare.
  • We report a 72-year-old Malay female with poorly-controlled diabetes mellitus who presented with a painful right parotid swelling associated with right facial nerve palsy.

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  • (PMID = 22589657.001).
  • [ISSN] 1394-195X
  • [Journal-full-title] The Malaysian journal of medical sciences : MJMS
  • [ISO-abbreviation] Malays J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
  • [Other-IDs] NLM/ PMC3336167
  • [Keywords] NOTNLM ; facial nerve injuries / neurosciences / parotid neoplasms / parotitis
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70. Forton GE, Van Parys G, Hertveldt K: Primary angiosarcoma of the non-irradiated parotid gland: a most uncommon, highly malignant tumor. Eur Arch Otorhinolaryngol; 2005 Mar;262(3):173-7
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  • [Title] Primary angiosarcoma of the non-irradiated parotid gland: a most uncommon, highly malignant tumor.
  • This case report discusses the clinical presentation, imaging, surgery and further treatment and course of a primary angiosarcoma of a non-irradiated parotid gland.
  • [MeSH-major] Hemangiosarcoma / secondary. Parotid Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Aged. Aged, 80 and over. Antigens, CD45 / immunology. Humans. Keratins / immunology. Magnetic Resonance Imaging. Male. Neoplasm Staging. Neoplasms, Second Primary / diagnostic imaging. Neoplasms, Second Primary / pathology. Tomography, X-Ray Computed

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  • [Cites] Head Neck. 1992 Jan-Feb;14(1):1-7 [1624288.001]
  • [Cites] Histopathology. 1998 Dec;33(6):586-7 [9870161.001]
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  • (PMID = 15133686.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 68238-35-7 / Keratins; EC 3.1.3.48 / Antigens, CD45
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71. Tarakji B, Kujan O, Nassani MZ: Immunohistochemical Expression of p53 in Pleomorphic Adenoma and Carcinoma Ex Pleomorphic Adenoma. J Cancer Epidemiol; 2010;2010:250606
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Context. Immunohistochemical stains for p53 are used as a diagnostic marker associated with malignancy in several histologic types of salivary gland tumors.
  • Objective. to evaluate whatever inactivation of tumor suppressor gene (p53) increases with the tumor progression from normal salivary tissue to PA and eventually CPA.
  • Design. Paraffin blocks of 29 cases of PA, which were surrounded by normal parotid gland, and 27 cases of carcinoma ex pleomorphic adenoma were retrieved and validated.
  • Results. The results showed negative nuclear expression of P53 in normal parotid gland.

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  • (PMID = 21253477.001).
  • [ISSN] 1687-8566
  • [Journal-full-title] Journal of cancer epidemiology
  • [ISO-abbreviation] J Cancer Epidemiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC3022193
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72. Markkanen-Leppänen M, Mäkitie AA, Passador-Santos F, Leivo I, Hagström J: Bilateral Basal cell adenocarcinoma of the parotid gland: in a recipient of kidney transplant. Clin Med Insights Pathol; 2010 Feb 18;3:1-5
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  • [Title] Bilateral Basal cell adenocarcinoma of the parotid gland: in a recipient of kidney transplant.
  • We report a rare case of bilateral basal cell adenocarcinoma (BcAC) of the parotid gland in a male patient 30 years after kidney transplantation and continuous administration of immunosuppressive therapy.
  • BcAC is a salivary gland malignancy first recognized as a distinct neoplastic entity in WHO classification of salivary gland tumours in 1991.
  • Over 90% of BcACs are detected in the parotid gland.
  • The most important differential diagnosis is basal cell adenoma.
  • Administration of immunosuppressive medication to this patient for three decades may have contributed to development of this rare neoplasia.

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  • (PMID = 21151548.001).
  • [ISSN] 1179-5557
  • [Journal-full-title] Clinical medicine insights. Pathology
  • [ISO-abbreviation] Clin Med Insights Pathol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2999998
  • [Keywords] NOTNLM ; basal cell adenocarcinoma / immunohistochemistry / post transplantation malignancy / salivary gland cancer
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73. Steele NP, Wenig BM, Sessions RB: A case of pleomorphic adenoma of the parotid gland metastasizing to a mediastinal lymph node. Am J Otolaryngol; 2007 Mar-Apr;28(2):130-3
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  • [Title] A case of pleomorphic adenoma of the parotid gland metastasizing to a mediastinal lymph node.
  • OBJECTIVE: Pleomorphic adenomas are the most common salivary gland tumors and are typically cured with complete surgical excision.
  • There are rare reports, however, in which these histologically benign tumors have inexplicably metastasized to distant sites.
  • We present a case of a patient who presented, 27 years after excision of a parotid pleomorphic adenoma, with a recurrence in the parotid bed and a mediastinal metastasis.
  • METHODS: A 43-year-old woman presented with a mass in the right parotid bed 27 years after excision of a pleomorphic adenoma of the parotid.
  • The patient's presentation, workup, and final diagnosis of benign metastasizing pleomorphic adenoma will be discussed, along with a pertinent review of the literature.
  • RESULTS: A diagnosis of recurrent pleomorphic adenoma was made from a fine needle aspiration biopsy of the right parotid mass.
  • Examination of the pathology specimens confirmed a diagnosis of pleomorphic adenoma in both the parotid bed and the mediastinum.
  • No histologic characteristics of malignancy were seen in either specimen; therefore, a diagnosis of benign metastasizing mixed tumor was rendered.
  • CONCLUSION: Benign metastasizing pleomorphic adenoma is a rare and controversial but distinct clinical entity.
  • Although the definition of the term benign precludes metastatic disease, these tumors do not demonstrate any malignant features yet metastasize to distant sites.
  • It remains to be determined whether these benign metastasizing pleomorphic adenomas are really low-grade salivary malignancies.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans. Lymphatic Metastasis. Mediastinum / pathology. Neoplasm Recurrence, Local / pathology

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  • (PMID = 17362821.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Sørensen KB, Godballe C, de Stricker K, Krogdahl A: Parotid carcinoma: expression of kit protein and epidermal growth factor receptor. J Oral Pathol Med; 2006 May;35(5):286-91
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  • [Title] Parotid carcinoma: expression of kit protein and epidermal growth factor receptor.
  • OBJECTIVES: Our aim is to investigate the expression of kit protein (KIT) and epidermal growth factor receptor (EGFR) in parotid carcinomas in order to correlate the expression to histology and prognosis.
  • PATIENTS AND METHODS: Formalin-fixed paraffin-embedded sections from 73 patients with parotid gland carcinomas were used for the study.
  • [MeSH-major] Carcinoma, Adenoid Cystic / chemistry. Parotid Neoplasms / chemistry. Proto-Oncogene Proteins c-kit / analysis. Receptor, Epidermal Growth Factor / analysis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. DNA Mutational Analysis. DNA, Neoplasm / analysis. Female. Humans. Immunohistochemistry. Male. Middle Aged. Survival Analysis

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  • (PMID = 16630292.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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75. Konoplev S, Lin P, Qiu X, Medeiros LJ, Yin CC: Clonal relationship of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue involving different sites. Am J Clin Pathol; 2010 Jul;134(1):112-8
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  • Patients with mucosa-associated lymphoid tissue (MALT) lymphoma often have multiple sites of disease at initial diagnosis or during the clinical course.
  • The specimen pairs were stomach and nasopharynx, stomach and lung, ocular adnexa and nasopharynx, and ocular adnexa and parotid gland.
  • [MeSH-minor] Adult. Aged. Antigens, Neoplasm / immunology. Biopsy, Needle. Clone Cells / immunology. Clone Cells / pathology. DNA, Neoplasm / genetics. Female. Humans. Immunophenotyping. Middle Aged. Polymerase Chain Reaction. Sequence Analysis, DNA

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  • (PMID = 20551275.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / DNA, Neoplasm
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76. Laskawi R, Ellies M: The role of botulinum toxin in the management of head and neck cancer patients. Curr Opin Otolaryngol Head Neck Surg; 2007 Apr;15(2):112-6
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  • RECENT FINDINGS: Patients with head and neck cancers of different etiologies often suffer from disorders concerning their musculature (for example, synkinesis in mimic muscles) or gland secretion in the head and neck region.
  • The application of botulinum toxin type A can improve movement disorders like synkinesis following reconstructive surgery in patients with cancers of the parotid gland, spasms of the pharyngo-esophageal musculature following laryngectomies and disorders of the autonomous nerve system like hypersalivation, hyperlacrimation and pathological sweating.

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  • (PMID = 17413413.001).
  • [ISSN] 1068-9508
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neuromuscular Agents; EC 3.4.24.69 / Botulinum Toxins, Type A
  • [Number-of-references] 20
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77. Krishnanand G, Kaur M, Rao RV, Monappa V: Oncocytic variant of mucoepidermoid carcinoma of submandibular gland: an unusual clinical and morphological entity. Indian J Pathol Microbiol; 2007 Jul;50(3):538-40
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  • [Title] Oncocytic variant of mucoepidermoid carcinoma of submandibular gland: an unusual clinical and morphological entity.
  • In this case report we describe a rare tumor--Oncocytic variant of Mucoepidermoid carcinoma of the submandibular salivary gland with a review of the literature.
  • Oncocytic metaplasia in salivary glands is a benign change that is associated with increasing age and also seen in a few salivary gland neoplasms', which include oncocytoma, Warthin's tumor, and the rare, oncocytic carcinoma.
  • Only twelve well-documented cases of oncocytic MEC have been reported previously all of which occurred in the parotid gland.
  • To the best of our knowledge this is the first case of oncocytic mucoepidermoid carcinoma involving the submandibular salivary gland.
  • The recognition of this entity is important, since most of the other primary oncocytic lesions of the salivary gland are benign.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Submandibular Gland Neoplasms / pathology

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  • (PMID = 17883126.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 10
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78. Carrillo JF, Ramírez R, Flores L, Ramirez-Ortega MC, Arrecillas MD, Ibarra M, Sotelo R, Ponce-De-León S, Oñate-Ocaña LF: Diagnostic accuracy of fine needle aspiration biopsy in preoperative diagnosis of patients with parotid gland masses. J Surg Oncol; 2009 Aug 1;100(2):133-8
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  • [Title] Diagnostic accuracy of fine needle aspiration biopsy in preoperative diagnosis of patients with parotid gland masses.
  • BACKGROUND: The use of fine needle aspiration biopsy (FNAB) for diagnosis of parotid gland masses (PGM) is questioned, because of low sensitivity and the generalized belief requiring surgery for most parotid masses.
  • Our objective was to evaluate the diagnostic accuracy of FNAB for diagnosis of patients with PGM.
  • The reference standard for diagnosis was the surgical pathology report.
  • RESULTS: FNAB sensitivity and specificity values in diagnosis of malignancy were 0.923 (95% confidence interval [CI], 0.85-0.99) and 0.986 (95% CI, 0.96-1.00), respectively.
  • Negative LR of FNAB was strengthened (0.078-0.029) when negative diagnosis of FNAB was associated with tumor size <4 cm, definite borders, and homogeneous tumor mass observed by computed tomography (CT).
  • [MeSH-major] Biopsy, Needle / methods. Parotid Gland / pathology. Parotid Neoplasms / diagnosis

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  • (PMID = 19507187.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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79. Guido A, Fuccio L, Rombi B, Castellucci P, Cecconi A, Bunkheila F, Fuccio C, Spezi E, Angelini AL, Barbieri E: Combined 18F-FDG-PET/CT imaging in radiotherapy target delineation for head-and-neck cancer. Int J Radiat Oncol Biol Phys; 2009 Mar 1;73(3):759-63
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  • The primary tumor sites were as follow: 20 oropharyngeal tumors, 4 laryngeal tumors, 2 hypopharyngeal tumors, 2 paranasal sinuses tumors, 9 nasopharyngeal tumors, and 1 parotid gland tumor.
  • The radiation oncologist defined all gross tumor volumes (GTVs) using both the PET/CT and CT scans.
  • Separate analyses of the difference between the CT- and PET/CT-based GTVs of the primary tumor compared with the GTVs of nodal disease were not statistically significant.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Staging. Radiotherapy Planning, Computer-Assisted / methods

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  • [CommentIn] Int J Radiat Oncol Biol Phys. 2009 Aug 1;74(5):1629; author reply 1629 [19515513.001]
  • (PMID = 18834671.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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80. Penn R, Abemayor E, Nabili V, Bhuta S, Kirsch C: Perineural invasion detected by high-field 3.0-T magnetic resonance imaging. Am J Otolaryngol; 2010 Nov-Dec;31(6):482-4
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  • We report on a patient with cutaneous squamous cell carcinoma invading the parotid gland with clinical evidence of facial nerve weakness.
  • On standard 1.5 Tesla (T) magnetic resonance imaging (MRI), bilateral parotid glands were symmetric; however, a second high-field 3-T MRI revealed asymmetric enhancement of the left facial nerve at the stylomastoid foramen and extending throughout the left parotid gland.
  • The presurgical determination of PNI was essential in our mapping the exact tumor location and in our surgical planning.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Cranial Nerve Neoplasms / diagnosis. Facial Nerve Diseases / diagnosis. Magnetic Resonance Imaging / methods. Skin Neoplasms / pathology
  • [MeSH-minor] Humans. Male. Middle Aged. Neoplasm Invasiveness. Parotid Neoplasms / diagnosis. Parotid Neoplasms / secondary

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20015797.001).
  • [ISSN] 1532-818X
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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81. Mahmood U, Nguyen JD, Chang J, Gu M, Wong BJ: Atypical lipomatous tumor/well-differentiated liposarcoma of the parotid gland: case report and literature review. Ear Nose Throat J; 2009 Oct;88(10):E10-6
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  • [Title] Atypical lipomatous tumor/well-differentiated liposarcoma of the parotid gland: case report and literature review.
  • According to our MEDLINE search, only 11 cases of liposarcoma of the parotid gland have been reported since 1968.
  • We report a new case of primary atypical lipomatous tumor/well-differentiated liposarcoma of the parotid gland in a 77-year-old man.
  • [MeSH-major] Lipoma / diagnosis. Liposarcoma / diagnosis. Parotid Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Parotid Gland / pathology. Parotid Gland / surgery

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  • (PMID = 19826985.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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82. Pomar Blanco P, Martín Villares C, San Román Carbajo J, Tapia Risueño M, Fernández Pello M: [Metastasis to the parotid gland]. Acta Otorrinolaringol Esp; 2006 Jan;57(1):47-50
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  • [Title] [Metastasis to the parotid gland].
  • [Transliterated title] Metastasis en la glandula parótida.
  • INTRODUCTION: Metastatic disease in the parotid gland has been observed and reported in the literature, and its treatment is controversial.
  • MATERIAL AND METHODS: We review 48 patients with parotid tumors that underwent surgery during 1997-2004.
  • RESULTS: Among these 48, there were 12 cases of metastatic tumors to the parotid (25%).
  • CONCLUSIONS: In our study parotid metastases are relatively common in patients submitted for parotid surgery.
  • Often the site of origin of the primary tumor is the facial skin, and the primary tumors most commonly are melanomas or squamous-cell carcinomas, but it is possible distant primary tumors below clavicules.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Kidney Neoplasms / pathology. Melanoma / secondary. Parotid Neoplasms / secondary

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  • (PMID = 16503033.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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83. Quenin S, Plouin-Gaudon I, Marchal F, Froehlich P, Disant F, Faure F: Juvenile recurrent parotitis: sialendoscopic approach. Arch Otolaryngol Head Neck Surg; 2008 Jul;134(7):715-9
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  • PATIENTS: Sialendoscopy was used to examine 10 children (age range, 1.8-13.0 years) with symptomatic JRP for recurrent swelling of the parotid glands between January 2003 and January 2005.
  • Initial data analyzed included the type of endoscope used as well as the size and form of the main duct of the parotid gland.
  • RESULTS: Initial ultrasound evaluation of the diseased gland revealed a white Stensen duct without the natural proliferation of blood vessels in all 10 cases.
  • Seventeen parotid glands were dilated in all 10 patients, with a success rate of 89%.
  • Sialendoscopic dilation of the main parotid ducts appears to be a safe and effective method for treating JRP.
  • [MeSH-major] Endoscopes. Parotitis / diagnosis. Salivary Ducts
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Constriction, Pathologic / diagnosis. Constriction, Pathologic / therapy. Diagnosis, Differential. Dilatation. Female. Follow-Up Studies. Humans. Infant. Male. Recurrence. Retreatment. Ultrasonography

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  • (PMID = 18645120.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Kopeć T, Wierzbicka M, Szyfter W: [Reconstruction of dissected Stensen's duct after facelift surgery]. Otolaryngol Pol; 2010 Jul-Aug;64(4):215-8
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  • Less common, but potentially serious, complications may include damage to the facial nerves and necrosis of the skin flaps, infection and damage of parotid duct.
  • We present a case of 50 years old woman, who has undergone facelift surgery with damage of parotid duct and consequently formation of sialocele.
  • We observed normal saliva flow from natural orifice of parotid gland.
  • [MeSH-major] Facial Paralysis / surgery. Parotid Gland / surgery. Rhytidoplasty / adverse effects. Salivary Ducts / surgery. Salivary Gland Diseases / surgery

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  • (PMID = 20873096.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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85. Chaari C, Ellouze S, Chamli H, Krichen Makni S, Karray F, Sellami Boudawara T: [Squamous cell carcinoma on a pleomorphic adenoma with amyloid stroma of the palate]. Rev Stomatol Chir Maxillofac; 2010 Feb;111(1):53-5
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  • INTRODUCTION: Squamous cell carcinoma ex-pleomorphic adenoma (CXAP) is a malignant and rare mixed tumor.
  • The physical examination revealed a hard and large tumor invading all the palate.
  • The diagnosis of CXAP was made on a biopsy.
  • A histological study confirmed the diagnosis after surgical resection of the tumor, specifying its noninvasive character.
  • DISCUSSION: CXAP is generally located in the parotid gland; it is very rarely located in the palate.

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  • (PMID = 19932498.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Amyloid; 68238-35-7 / Keratins; EC 3.4.24.11 / Neprilysin
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86. Saylam G, Tanrikulu S, Dursun E, Iriz A, Eryilmaz A: A mass at fat density in the parotid gland: dermoid cyst or lipoma. B-ENT; 2009;5(1):43-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A mass at fat density in the parotid gland: dermoid cyst or lipoma.
  • A mass at fat density in the parotid gland: dermoid cyst or lipoma.
  • DCs of the parotid gland are even rarer.
  • In this article, a 42-year-old female patient with DC of the parotid gland is presented and discussed with a brief review of the literature.
  • Radiologic findings suggested that the mass was a lipoma, but observation of a hair in the cyst during surgery changed the clinical diagnosis to DC; this suspicion was confirmed by pathological analysis.
  • Although DCs are rare among the parotid masses, they should be kept in mind during the differential diagnosis.
  • [MeSH-major] Dermoid Cyst / pathology. Lipoma / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 19455999.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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87. Busch L, Sterin-Borda L, Borda E: An overview of autonomic regulation of parotid gland activity: influence of orchiectomy. Cells Tissues Organs; 2006;182(3-4):117-28
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  • [Title] An overview of autonomic regulation of parotid gland activity: influence of orchiectomy.
  • The parotid gland participates in the digestive process by providing fluid, electrolytes and enzymes that facilitate the onset of digestion.
  • The autonomic system is the main regulatory mechanism of the gland.
  • The parasympathetic system controls basal activity of the gland acting on M(1) and M(3) muscarinic acetylcholine receptors and induces the secretion of fluid saliva rich in electrolytes through the modulation of ion channels and the Na(+)-K(+)-ATPase activity.
  • [MeSH-major] Orchiectomy. Parasympathetic Nervous System / physiology. Parotid Gland / metabolism

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  • (PMID = 16914915.001).
  • [ISSN] 1422-6405
  • [Journal-full-title] Cells, tissues, organs
  • [ISO-abbreviation] Cells Tissues Organs (Print)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Receptors, Muscarinic; EC 3.2.1.- / Amylases; EC 3.6.3.9 / Sodium-Potassium-Exchanging ATPase
  • [Number-of-references] 78
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88. Adnyane IK, Zuki AB, Noordin MM, Agungpriyono S: Histological study of the parotid and mandibular glands of barking deer (Muntiacus muntjak) with special reference to the distribution of carbohydrate content. Anat Histol Embryol; 2010 Dec;39(6):516-20
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  • [Title] Histological study of the parotid and mandibular glands of barking deer (Muntiacus muntjak) with special reference to the distribution of carbohydrate content.
  • We investigated the histology and carbohydrate content of the parotid and mandibular glands of the barking deer (Muntiacus muntjak).
  • The acinar cells of the parotid gland were serous, whereas those of the mandibular gland were of the mixed type.
  • The acini of the mandibular gland comprised serous and mucous cells with the mucous type predominating.
  • AB and PAS staining showed high concentrations of acidic and neutral carbohydrates in the mucous cells, but not in the serous cells of the mandibular gland.
  • However, these carbohydrates were not found in acinar cells of the parotid gland or in the serous cells of the mandibular gland.
  • [MeSH-major] Carbohydrates / analysis. Muntjacs / anatomy & histology. Parotid Gland / anatomy & histology. Parotid Gland / chemistry. Saliva / chemistry. Submandibular Gland / anatomy & histology. Submandibular Gland / chemistry

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  • [Copyright] © 2010 Blackwell Verlag GmbH.
  • (PMID = 20682009.001).
  • [ISSN] 1439-0264
  • [Journal-full-title] Anatomia, histologia, embryologia
  • [ISO-abbreviation] Anat Histol Embryol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Carbohydrates
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89. Andruchow JL, Veness MJ, Morgan GJ, Gao K, Clifford A, Shannon KF, Poulsen M, Kenny L, Palme CE, Gullane P, Morris C, Mendenhall WM, Patel KN, Shah JP, O'Brien CJ: Implications for clinical staging of metastatic cutaneous squamous carcinoma of the head and neck based on a multicenter study of treatment outcomes. Cancer; 2006 Mar 1;106(5):1078-83
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  • BACKGROUND: Cutaneous squamous cell carcinoma (SCC) of the head and neck is a common cancer that has the potential to metastasize to lymph nodes in the parotid gland and neck.
  • All had metastatic cutaneous SCC involving the parotid gland and/or neck and all were treated for cure with a minimum followup time of 2 years.
  • These patients were restaged using a newly proposed system that separated parotid disease (P stage) from neck disease (N stage) and included subgroups of P and N stage.
  • Metastases involved the parotid in 260 patients (149 P1; 78 P2; 33 P3) and 43 of these had clinical neck disease also (22 N1; 21 N2).
  • RESULTS: Neck nodes were pathologically involved in 32% of patients with parotid metastases.
  • Disease recurred in 105 (33%) of the 322 patients, involving the parotid in 42, neck in 33, and distant sites in 30.
  • Parotid recurrence did not vary significantly with P stage.
  • Survival was significantly worse for patients with advanced P stage: 69% survival at 5 years compared with 82% for those with early P stage (P = 0.02) and for those with both parotid and neck node involvement pathologically: 61% survival compared with 79% for those with parotid disease alone (P = 0.027).
  • Clinical neck involvement among patients with parotid metastases did not significantly worsen survival (P = 0.1).
  • The hypothesis that separation of parotid and neck disease in a new staging system is supported by the results.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Head and Neck Neoplasms / pathology. Lymphatic Metastasis. Neoplasm Staging. Parotid Neoplasms / secondary

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  • (PMID = 16444748.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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90. Hernández Sandemetrio R, Armengot Carceller M, Alba García JR, Taleb C, Jiménez Roig JP, Frías Moya-Angeler S, Basterra Alegría J: [Pleomorphic adenoma of deep lobe of the parotid gland]. Acta Otorrinolaringol Esp; 2006 Jan;57(1):56-8
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  • [Title] [Pleomorphic adenoma of deep lobe of the parotid gland].
  • [Transliterated title] Adenoma pleomorfo gigante de lóbulo profundo de la parótida: a propósito de un caso.
  • This report describes a case of a pleomorphic adenoma in the deep lobe of the parotid gland presented like a parapharyngeal mass, and its diagnosis and treatment.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Neoplasm Staging

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  • (PMID = 16503035.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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91. Maiorano E, Capodiferro S, Fanelli B, Calabrese L, Napoli A, Favia G: Hamartomatous angiolipoma of the parotid gland (sialoangiolipoma). Head Neck Pathol; 2008 Mar;2(1):36-40
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  • [Title] Hamartomatous angiolipoma of the parotid gland (sialoangiolipoma).
  • Mesenchymal tumors of the salivary glands are rare and mostly localized to the parotid gland.
  • We report on the clinico-pathological features of a distinct parotid tumor occurred in a newborn, showing glandular structures admixed with mature lipocytes and blood vessels in variable proportions.
  • This was a well-circumscribed and slowly growing nodule of the superficial parotid lobe, mostly reddish in color with white-yellowish striations.
  • [MeSH-major] Angiolipoma / pathology. Hamartoma / pathology. Parotid Gland / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Child, Preschool. Female. Humans. Infant, Newborn

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  • [Cites] Histopathology. 2000 Mar;36(3):285-6 [10809601.001]
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  • (PMID = 20614340.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807606
  • [Keywords] NOTNLM ; Angiolipoma / Lipoma / Salivary gland neoplasms / Sialolipoma / Soft tissue tumors
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92. Yanardag H: Parotid gland involvement in sarcoidosis. South Med J; 2005 Feb;98(2):258-9
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  • [Title] Parotid gland involvement in sarcoidosis.
  • [MeSH-major] Parotid Diseases / complications. Parotid Gland / pathology. Sarcoidosis / complications

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  • (PMID = 15759966.001).
  • [ISSN] 0038-4348
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] United States
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93. Sethi A, Mrig S, Sethi D, Mandal AK, Agarwal AK: Parotid gland leiomyosarcoma in a child: an extremely unusual neoplasm. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Jul;102(1):82-4
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  • [Title] Parotid gland leiomyosarcoma in a child: an extremely unusual neoplasm.
  • We report the case of an 8-year-old boy with a parotid mass diagnosed to be a leiomyosarcoma.
  • [MeSH-major] Leiomyosarcoma / pathology. Parotid Neoplasms / pathology

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  • (PMID = 16831677.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 10
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94. Nassie DI, Berkowitz M, Wolf M, Kronenberg J, Talmi YP: Parotid mass as presenting symptom of lymphoma. Isr Med Assoc J; 2010 Jul;12(7):416-8
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  • [Title] Parotid mass as presenting symptom of lymphoma.
  • BACKGROUND: Lymphomas arising from the parotid gland are an uncommon entity, said to account for only 0.6-5% of tumors or tumor-like lesions of the parotid, and are therefore commonly overlooked.
  • METHODS: We retrospectively reviewed our experience with patients diagnosed and treated for parotid lymphoma in our medical center during the period 1998-2008.
  • In eight, parotid mass was the first manifestation of the disease, while in five who were in clinical remission its reoccurrence was first manifested in the parotid gland.
  • Mean survival was 6.3 years CONCLUSIONS: Since parotid lymphoma is uncommon, it is often overlooked in the differential diagnosis.
  • Methods of diagnosing and treating parotid lymphoma are different from those of other parotid pathologies.
  • A high index of suspicion is warranted in order to provide a quick and efficient diagnosis and treatment without subjecting the patient to unnecessary tests and procedures.
  • [MeSH-major] Lymphoma / diagnosis. Parotid Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Female. Hodgkin Disease / diagnosis. Humans. Lymphoma, Non-Hodgkin / diagnosis. Male. Middle Aged. Retrospective Studies

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  • (PMID = 20862822.001).
  • [ISSN] 1565-1088
  • [Journal-full-title] The Israel Medical Association journal : IMAJ
  • [ISO-abbreviation] Isr. Med. Assoc. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Israel
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95. Saylam C, Ucerler H, Orhan M, Ozek C: Anatomic landmarks of the buccal branches of the facial nerve. Surg Radiol Anat; 2006 Oct;28(5):462-7
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  • The aim of this study was to classify the buccal branches of the facial nerve in relation to the parotid duct and its relevance to surgical procedures such as rhytidectomy and parotid gland surgery.
  • The vertical and horizontal relationships between the buccal branches of the facial nerve and tragus, and parotid duct were recorded and analyzed.
  • The buccal branches of the facial nerve were classified into four types: Type I: a single buccal branch of the facial nerve at the point of emergence from the parotid gland and inferior to the parotid duct.
  • Type II: a single buccal branch of the facial nerve at the point of emergence from the parotid gland and superior to the parotid duct.
  • Type IV: two branches of buccal branch; one superior and one inferior to the duct at the point of emergence from the parotid gland.
  • [MeSH-minor] Adult. Female. Humans. Male. Parotid Gland / anatomy & histology

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  • (PMID = 16838086.001).
  • [ISSN] 0930-1038
  • [Journal-full-title] Surgical and radiologic anatomy : SRA
  • [ISO-abbreviation] Surg Radiol Anat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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96. Zhang J, Zhang JG, Cai ZG, Zhang Y, Huang MX, Yu GY: [125I seed implant brachytherapy of recurrent parotid gland malignant tumor]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2009 Jan;44(1):2-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [125I seed implant brachytherapy of recurrent parotid gland malignant tumor].
  • OBJECTIVE: To investigate the efficacy of radioactive seeds for the treatment of recurrence malignant parotid gland tumors.
  • METHODS: Thirty-three patients with recurrence malignant parotid gland tumor treated by radioactive seeds were retrospectively reviewed.
  • Thirty patients underwent both tumor resection and radioactive seeds implanting.
  • CONCLUSIONS: Radioactive seeds implanting combined with operation or implanting radioactive seeds alone for the treatment of recurrent malignant parotid gland tumors could get good local control and treatment effects.
  • [MeSH-major] Brachytherapy. Neoplasm Recurrence, Local / radiotherapy. Parotid Neoplasms / radiotherapy

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  • (PMID = 19489249.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
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97. Chakraborty PP, Bhattacharjee R, Chatterjee K: Parotid gland cysticercosis. J Assoc Physicians India; 2007 Oct;55:717
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  • [Title] Parotid gland cysticercosis.
  • [MeSH-major] Brain Edema / pathology. Neurocysticercosis / pathology. Parotid Diseases / pathology. Parotid Gland / pathology

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  • (PMID = 18173024.001).
  • [ISSN] 0004-5772
  • [Journal-full-title] The Journal of the Association of Physicians of India
  • [ISO-abbreviation] J Assoc Physicians India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] F4216019LN / Albendazole
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98. Meer S, Altini M: Sclerosing polycystic adenosis of the buccal mucosa. Head Neck Pathol; 2008 Mar;2(1):31-5
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  • Most of the 47 reported cases have occurred within the parotid gland, with only a single case being described within the buccal mucosa.
  • Even though SPA has satisfied the criteria for monoclonality, the debate as to whether SPA represents a true neoplasm or a pseudoneoplastic inflammatory sclerosing process, with low-grade neoplastic potential continues.
  • Awareness of the occurrence of this lesion in both major and minor salivary glands is important to promote its differentiation from other more sinister salivary gland pathology.

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  • (PMID = 20614339.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807607
  • [Keywords] NOTNLM ; Immunohistochemistry / Salivary glands / Sclerosing polycystic adenosis
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99. Miyagi T, Nagasaki A, Taira T, Shinhama A, Suzuki M, Ohshima K, Takasu N: Extranodal adult T-cell leukemia/lymphoma of the head and neck: a clinicopathological study of nine cases and a review of the literature. Leuk Lymphoma; 2009 Feb;50(2):187-95
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  • Tumors involved the parotid gland, sinonasal tract, masseter muscle, mandible and skull.
  • ATLL should be included in the differential diagnosis of extranodal head and neck lymphoma.

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  • [CommentIn] Leuk Lymphoma. 2009 Feb;50(2):148-9 [19235009.001]
  • [CommentIn] Leuk Lymphoma. 2009 Feb;50(2):150-1 [19235010.001]
  • (PMID = 19197730.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 50
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100. El-Monem MH, Gaafar AH, Magdy EA: Lipomas of the head and neck: presentation variability and diagnostic work-up. J Laryngol Otol; 2006 Jan;120(1):47-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Three patients had deep lipomas affecting the hypopharynx, larynx and parotid gland; all were correctly diagnosed pre-operatively.
  • CONCLUSIONS: Lipomas should be considered in the differential diagnosis of soft-tissue head and neck masses even in rare locations.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Lipoma / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Hypopharyngeal Neoplasms / diagnosis. Hypopharyngeal Neoplasms / pathology. Hypopharyngeal Neoplasms / radiography. Laryngeal Neoplasms / diagnosis. Laryngeal Neoplasms / pathology. Laryngeal Neoplasms / radiography. Magnetic Resonance Imaging / methods. Male. Middle Aged. Parotid Neoplasms / diagnosis. Parotid Neoplasms / pathology. Parotid Neoplasms / radiography. Retrospective Studies. Tomography, X-Ray Computed / methods

  • MedlinePlus Health Information. consumer health - Head and Neck Cancer.
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  • (PMID = 16359147.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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