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Items 1 to 43 of about 43
1. Marocchio LS, Júnior DS, de Sousa SC, Fabre RF, Raitz R: Multifocal diffuse oral melanoacanthoma: a case report. J Oral Sci; 2009 Sep;51(3):463-6
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  • [Title] Multifocal diffuse oral melanoacanthoma: a case report.
  • Oral melanoacanthoma (OMA) is a rare benign lesion characterized by colonization of acanthotic epithelium by dendritic melanocytes.
  • [MeSH-minor] Aged. Female. Humans. Melanocytes / pathology. Mouth Mucosa / pathology. Neoplasm Regression, Spontaneous

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  • (PMID = 19776516.001).
  • [ISSN] 1880-4926
  • [Journal-full-title] Journal of oral science
  • [ISO-abbreviation] J Oral Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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2. Brasileiro BF, Martins-Filho PR, Piva MR, da Silva LC, Nonaka CF, Miguel MC: Myofibroma of the oral cavity. A rare spindle cell neoplasm. Med Oral Patol Oral Cir Bucal; 2010 Jul;15(4):e596-600
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  • [Title] Myofibroma of the oral cavity. A rare spindle cell neoplasm.
  • Myofibroma is an uncommon spindle cell neoplasm rarely found in oral cavity.
  • In the oral cavity, myofibroma occurs within the submucosal or intramuscular tissue and has a predilection by the tongue, buccal mucosa and lips.
  • Misdiagnosis included benign and malignant spindle cell lesions of nerve tissue or smooth muscle origin, such as neurofibroma, leiomyoma and sarcomas.

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  • (PMID = 20038894.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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3. Nikitakis NG, Argyris P, Sklavounou A, Papadimitriou JC: Oral myoepithelioma of soft tissue origin: report of a new case and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Nov;110(5):e48-51
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  • [Title] Oral myoepithelioma of soft tissue origin: report of a new case and literature review.
  • Oral myoepithelioma of soft tissue origin, an entity distinct from myoepithelioma of salivary glands, constitutes an extremely rare benign neoplasm, with only 1 previously published case, affecting the tongue of a 22-year-old woman.
  • Ectomesenchymal chondromyxoid tumour (ECT) also is a very rare benign neoplasm of the oral cavity that has a strong predilection for the anterior dorsum of the tongue.
  • A review of the relevant literature is made and the relationship between oral STM and ECT discussed.
  • [MeSH-minor] Actins / analysis. Antigens, CD57 / analysis. Cell Nucleus / ultrastructure. Chromatin / ultrastructure. Cytoplasm / ultrastructure. Desmin / analysis. Diagnosis, Differential. Glial Fibrillary Acidic Protein / analysis. Humans. Male. Middle Aged. Mouth Mucosa / pathology. Muscle, Skeletal / pathology. Neoplasms, Complex and Mixed / diagnosis. S100 Proteins / analysis. Vimentin / analysis

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  • [Copyright] Copyright © 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20955943.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD57; 0 / Chromatin; 0 / Desmin; 0 / Glial Fibrillary Acidic Protein; 0 / S100 Proteins; 0 / Vimentin
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4. Zong ZH, Shang DH, Sun CF: [Expression of Livin mRNA and protein in human oral squamous cell carcinoma]. Shanghai Kou Qiang Yi Xue; 2007 Jun;16(3):315-8
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  • [Title] [Expression of Livin mRNA and protein in human oral squamous cell carcinoma].
  • PURPOSE: To investigate the expression of the newly found inhibitor of apoptosis protein Livinalpha and Livinbeta and their gene expression in human oral squamous cell carcinoma.
  • METHODS: Twenty specimens of human squamous cell carcinoma(SCC), 15 cases of benign cysts, 10 cases of normal oral mucosal tissues adjacent to the cancerous lesions were examined.
  • RESULTS: Livin protein and mRNA expression was detected in 19 SCC tissues,14 benign cysts and 10 normal oral mucosal tissues adjacent to the cancerous lesions.But the expressions were significantly higher in oral SCC than in benign cysts and normal oral mucosal tissues (P<0.01).
  • CONCLUSION: Livin may play an important role in the tumorigenesis and development of human oral squamous cell carcinoma.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / biosynthesis. Carcinoma, Squamous Cell / metabolism. Inhibitor of Apoptosis Proteins / biosynthesis. Mouth Neoplasms / metabolism. Neoplasm Proteins / biosynthesis
  • [MeSH-minor] Apoptosis. Cell Transformation, Neoplastic. Humans. Mouth Mucosa. RNA, Messenger. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17660923.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / BIRC7 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Neoplasm Proteins; 0 / RNA, Messenger
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5. Saleh HA, Clayman L, Masri H: Fine needle aspiration biopsy of intraoral and oropharyngeal mass lesions. Cytojournal; 2008;5:4
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  • BACKGROUND: Fine needle aspiration (FNA) biopsy has been rarely used in oral and oropharyngeal lesions.
  • The goal of this study was to assess the value and accuracy of FNA biopsy in the diagnosis of oral and oropharyngeal lesions particularly in regards to discriminating benign from malignant tumors.
  • The sites of involvement were: lip 1, maxillary sinus 3, pharynx/oropharynx 5, floor of mouth 4, buccal mucosa 2 and peritonsillar area 1.
  • Cytologically, 7 cases were diagnosed as suspicious/malignant, and 9 cases as benign (including 6 benign neoplasm, 1 atypical, and 2 reactive or "descriptive").
  • Fifteen cases had corresponding surgical resection for histologic examination, of these, 9 cases were interpreted as malignant, and 6 as benign.
  • Two cases were interpreted as benign or atypical cytologically, but were found to be malignant on histologic examination.

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  • (PMID = 18373853.001).
  • [ISSN] 1742-6413
  • [Journal-full-title] CytoJournal
  • [ISO-abbreviation] Cytojournal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2329665
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6. Al-Khateeb TH: Benign oral masses in a Northern Jordanian population-a retrospective study. Open Dent J; 2009;3:147-53
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  • [Title] Benign oral masses in a Northern Jordanian population-a retrospective study.
  • The aim of this study was to evaluate the relative frequencies, types and distribution of benign oral masses in North Jordanians.
  • The records of the Department of Pathology at Jordan University of Science & Technology were reviewed and analyzed for patients with benign oral soft tissue masses, received during an 11-year period (1991-2001).
  • A sum of 818 benign oral soft tissue masses (4% neoplastic and 96% non-neoplastic) was analyzed.
  • Common benign neoplasms were salivary pleomorphic adenoma and lipoma.
  • The sites commonly affected by benign neoplasms were the palate, tongue, upper lip and buccal mucosa, in a descending order and the sites commonly affected by non-neoplastic lesions were the gingiva, buccal mucosa, lower lip and tongue in a descending order.
  • It is concluded that some of the features of benign oral masses in north Jordanians published in this paper are similar to those from other countries, and some are different.
  • Further nationwide population-based surveys are needed to further define the epidemiology of benign oral masses among Jordanians.

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  • (PMID = 19672335.001).
  • [ISSN] 1874-2106
  • [Journal-full-title] The open dentistry journal
  • [ISO-abbreviation] Open Dent J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2724667
  • [Keywords] NOTNLM ; Benign lesions of the upper aerodigestive tract / Jordanians. / Oral cavity tumor / Soft tissue neoplasm
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7. Prochasek W, Koszowski R, Steplewska K: [A rare case of neurilemmoma of the floor of the mouth]. Wiad Lek; 2008;61(7-9):236-8
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  • Neurilemmoma is a benign neoplasm of neuroectodermal origin.
  • The authors present a rare case of this lesion localized in the oral cavity.
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Mouth Mucosa / pathology. Mouth Mucosa / surgery. Treatment Outcome. Young Adult

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  • (PMID = 19172839.001).
  • [ISSN] 0043-5147
  • [Journal-full-title] Wiadomości lekarskie (Warsaw, Poland : 1960)
  • [ISO-abbreviation] Wiad. Lek.
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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8. Hong R, Lim SC: Granular cell tumor of the cecum with extensive hyalinization and calcification: a case report. World J Gastroenterol; 2009 Jul 14;15(26):3315-8
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  • A granular cell tumor (GCT) is a benign neoplasm of unclear histogenesis that is generally believed to be of nerve sheath origin.
  • The tumor was located between the mucosa and subserosa, and was composed of plump histiocyte-like tumor cells with abundant granular eosinophilic cytoplasm, which were immunoreactive for S-100 protein, vimentin, neuron-specific enolase, inhibin-alpha and calretinin.
  • Extensive hyalinization and calcification showing involution of tumor cells suggest benign clinical behavior of GCT.

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  • (PMID = 19598311.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / S100 Calcium Binding Protein G; 0 / S100 Proteins; 0 / Vimentin; EC 4.2.1.11 / Phosphopyruvate Hydratase
  • [Other-IDs] NLM/ PMC2710791
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9. Mohri Y, Mohri T, Wei W, Qi YJ, Martin A, Miki C, Kusunoki M, Ward DG, Johnson PJ: Identification of macrophage migration inhibitory factor and human neutrophil peptides 1-3 as potential biomarkers for gastric cancer. Br J Cancer; 2009 Jul 21;101(2):295-302
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  • METHODS: Surface-enhanced laser desorption/ionisation time-of-flight mass spectrometry (SELDI) and antibody arrays were used to compare protein expression in 21 pairs of gastric cancer tissue and adjacent normal mucosa and serum from 51 gastric cancer patients and 29 patients with benign gastric diseases.
  • RESULTS: Tissue analysis shows human neutrophil peptides 1-3 (HNPs 1-3) elevated 10-fold (P=0.001) in gastric cancer relative to adjacent normal mucosa.
  • Macrophage migration inhibitory factor (MIF) was increased five-fold (P=1.84 x 10(-7)) in the serum of gastric cancer patients relative to individuals with benign gastric disease.

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  • (PMID = 19550422.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] ENG
  • [Grant] United Kingdom / Cancer Research UK / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Blood Proteins; 0 / Macrophage Migration-Inhibitory Factors; 0 / Neoplasm Proteins; 0 / alpha-Defensins; 0 / human neutrophil peptide 1; 0 / human neutrophil peptide 2; 0 / human neutrophil peptide 3
  • [Other-IDs] NLM/ PMC2720195
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10. Diniz MG, Borges ER, Guimarães AL, Moreira PR, Brito JA, Gomez MV, De Marco L, Gomez RS: PTCH1 isoforms in odontogenic keratocysts. Oral Oncol; 2009 Mar;45(3):291-5
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  • Odontogenic keratocyst (OKC) is an aggressive benign odontogenic neoplasm associated with PTCH1 alteration.
  • In addition, the pattern of exon 1 expression observed in oral mucosa adjacent to the OKC was similar to the OKC tumor.
  • In conclusion, this report showed overactivity of Hedgehog (HH) pathway in OKC lesion and at adjacent oral mucosa.
  • [MeSH-minor] Adolescent. Adult. Basal Cell Nevus Syndrome / genetics. Basal Cell Nevus Syndrome / metabolism. Exons / genetics. Female. Humans. Male. Middle Aged. Mouth Mucosa / metabolism. Protein Isoforms / genetics. Protein Isoforms / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Signal Transduction. Young Adult

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  • (PMID = 18674957.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Protein Isoforms; 0 / Receptors, Cell Surface; 0 / patched receptors
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11. Sugiyama T, Nakagawa T, Narita M, Nakamura S, Inui M, Tagawa T: Pedunculated oncocytic carcinoma in buccal mucosa: immunohistochemical and ultrastructural studies. Oral Dis; 2006 May;12(3):324-8
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  • [Title] Pedunculated oncocytic carcinoma in buccal mucosa: immunohistochemical and ultrastructural studies.
  • PURPOSE: In this study we evaluated pedunculated oncocytic carcinoma (OC) in the buccal mucosa via immunohistochemical and ultrastructural studies.
  • PATIENT AND METHODS: An 84-year-old man was referred to our clinic with a pedunculated mass about 4 cm in diameter in the right buccal mucosa.
  • CONCLUSIONS: Because the histopathologic features of OC are similar to those of benign oncocytoma, the diagnosis of OC must be confirmed by a combination of clinical and ultrastructural characteristics.
  • [MeSH-minor] Aged, 80 and over. Cheek / pathology. Humans. Immunohistochemistry. Keratins / analysis. Male. Microscopy, Electron, Transmission. Mitochondria / pathology. Mouth Mucosa / pathology. Mucin-1 / analysis. Neoplasm Invasiveness

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  • (PMID = 16700744.001).
  • [ISSN] 1354-523X
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Mucin-1; 68238-35-7 / Keratins
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12. Westernoff TH, Jordan RC, Regezi JA, Ramos DM, Schmidt BL: Beta-6 Integrin, tenascin-C, and MMP-1 expression in salivary gland neoplasms. Oral Oncol; 2005 Feb;41(2):170-4
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  • The results showed that the malignant tumors were higher expressors of beta-6 than the benign tumors.
  • No significant difference was observed between ACCs and PLGAs. beta-6 expression was rarely seen in normal salivary gland epithelium and was occasionally present in mucosa overlying the tumors.
  • We conclude that ACCs and PLGAs express beta-6, tenascin-C, and MMP-1, but that their expression patterns are not significantly different. beta-6 appears to be more closely associated with the malignant tumors, and MMP-1 more closely associated with the benign tumors.
  • We believe that beta-6, tenascin-C, and MMP-1 proteins are part of the molecular repertoire used by salivary tumors for malignant invasion and benign tumor expansion.
  • [MeSH-major] Integrin beta Chains / metabolism. Matrix Metalloproteinase 1 / metabolism. Neoplasm Proteins / metabolism. Salivary Gland Neoplasms / metabolism. Tenascin / metabolism

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  • (PMID = 15695119.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Grant] United States / PHS HHS / / 11RT-0141; United States / PHS HHS / / 12KT-0166; United States / NCI NIH HHS / CA / CA095231; United States / NIDCR NIH HHS / DE / DE14609; United States / NIDCR NIH HHS / DE / K23DE00443; United States / NIDCR NIH HHS / DE / P01DE13904; United States / NIDCR NIH HHS / DE / R0I DE12856; United States / NIDCR NIH HHS / DE / R0I DEO11930
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Integrin beta Chains; 0 / Neoplasm Proteins; 0 / Tenascin; 0 / integrin beta6; EC 3.4.24.7 / Matrix Metalloproteinase 1
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13. Martín-Ezquerra G, Salgado R, Toll A, Gilaberte M, Baró T, Alameda Quitllet F, Yébenes M, Solé F, Garcia-Muret M, Espinet B, Pujol RM: Multiple genetic copy number alterations in oral squamous cell carcinoma: study of MYC, TP53, CCDN1, EGFR and ERBB2 status in primary and metastatic tumours. Br J Dermatol; 2010 Nov;163(5):1028-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple genetic copy number alterations in oral squamous cell carcinoma: study of MYC, TP53, CCDN1, EGFR and ERBB2 status in primary and metastatic tumours.
  • BACKGROUND: Oncogenesis in the oral cavity is believed to result from genetic alterations that cause a stepwise transformation of the mucosa to invasive carcinoma.
  • In oral squamous cell carcinoma (OSCC) multiple cytogenetic abnormalities have been reported, but their practical significance remains uncertain.
  • METHODS: Fifty-one consecutive samples of OSCC, nine lymph node biopsies showing metastatic spread from OSCC, 16 biopsies diagnosed as oral leucoplakia (OLK), 13 samples corresponding to oral lichen planus (OLP) and 14 samples from normal oral mucosa were included in the study.
  • Overexpression of p53, Myc, Cyclin D1, c-erbB-2 and epidermal growth factor receptor (EGFR) was more prevalent in malignant samples than benign samples (P < 0·05).
  • Evaluation of the genetic status of TP53, MYC, CCND1, ERBB2 and EGFR may be an additional diagnostic tool in distinguishing benign from malignant oral lesions in histopathologically challenging cases.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Biopsy. Cyclin D1 / genetics. Cyclin D1 / metabolism. Female. Genes, p53 / genetics. Humans. Lymph Nodes. Male. Middle Aged. Neoplasm Metastasis / genetics. Proto-Oncogene Proteins c-myc / genetics. Proto-Oncogene Proteins c-myc / metabolism. Receptor, Epidermal Growth Factor / genetics. Receptor, Epidermal Growth Factor / metabolism. Receptor, ErbB-2 / genetics. Receptor, ErbB-2 / metabolism


14. Rawal YB, Anderson KM, Rawal SY: Multinucleate cell angiohistiocytoma: an uncommon mucosal tumour. Clin Exp Dermatol; 2009 Apr;34(3):333-6
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  • Multinucleate cell angiohistiocytoma (MCAH) is an uncommon benign soft-tissue lesion with characteristic histological and immunohistochemical features.
  • It is unclear if it represents a benign neoplasm or a reactive/inflammatory process.
  • This is the first documentation of MCAH within the oral cavity.
  • Because of the benign nature of this lesion, a conservative approach is recommended in its management.
  • [MeSH-minor] Adult. Cell Nucleus / pathology. Dendritic Cells / pathology. Dental Caries / complications. Humans. Male. Mouth Mucosa / pathology

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  • (PMID = 19040523.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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15. Daskala I, Kalyvas D, Kolokoudias M, Vlachodimitropoulos D, Alexandridis C: Central odontogenic fibroma of the mandible: a case report. J Oral Sci; 2009 Sep;51(3):457-61
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  • It has been defined as a benign neoplasm, which appears in the jaw.
  • The lesion was an asymptomatic mass with well-defined borders covered by normal mucosa.

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  • (PMID = 19776515.001).
  • [ISSN] 1880-4926
  • [Journal-full-title] Journal of oral science
  • [ISO-abbreviation] J Oral Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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16. Andrade ES, Filho JR, Rocha NS, Neto IC, Camargo IB: Isolated intra-oral granular cell tumor: report of two cases and review of the literature. Acta Odontol Latinoam; 2010;23(2):99-104
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  • [Title] Isolated intra-oral granular cell tumor: report of two cases and review of the literature.
  • The tongue and the buccal mucosa are common intra oral sites.
  • Although aggressive and malignant variants of this neoplasm have been described, most GCTs are benign.
  • As most granular cell tumors are benign, surgical excision of the lesion is the treatment of choice.
  • In this study, 2 oral GCT cases are presented, corresponding to 2 male patients, with a mean age of 27 years and a mean time of evolution of the lesions of 8 months.
  • The main clinical pathology and diagnostic features of this neoplasm are reviewed and discussed.

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  • (PMID = 21053681.001).
  • [ISSN] 0326-4815
  • [Journal-full-title] Acta odontológica latinoamericana : AOL
  • [ISO-abbreviation] Acta Odontol Latinoam
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Argentina
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17. Mortuaire G, Pasquesoone X, Leroy X, Chevalier D: Respiratory epithelial adenomatoid hamartomas of the sinonasal tract. Eur Arch Otorhinolaryngol; 2007 Apr;264(4):451-3
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  • Fine histopathological analysis is necessary to avoid aggressive surgery for this benign lesion.
  • [MeSH-major] Adenomatoid Tumor / pathology. Hamartoma / pathology. Paranasal Sinus Neoplasms / pathology. Respiratory Mucosa / pathology
  • [MeSH-minor] Adult. Endoscopy. Female. Humans. Middle Aged. Neoplasm Invasiveness

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  • [Cites] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 May;97(5):607-12 [15153874.001]
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  • (PMID = 17089137.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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18. Singhi AD, Montgomery EA: Colorectal granular cell tumor: a clinicopathologic study of 26 cases. Am J Surg Pathol; 2010 Aug;34(8):1186-92
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  • Granular cell tumor (GCT) is commonly located in the subcutaneous tissue and oral cavity, and uncommon in the gastrointestinal tract, in which the majority arises in the esophagus with over-representation in African Americans (AA).
  • Of the 20 cases available for histologic review, the tumors were noted to either be infiltrative (12/20, 60%) or marginated (8/20, 40%) involving either the mucosa (7/20, 35%), submucosa (10/20, 50%), or both (3/20, 15%).
  • Although GCTs were benign tumors in this series, if incompletely excised regrowth of the lesion may occur and therefore, follow-up may be warranted.
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Biopsy. Colectomy. Colonoscopy. Female. Humans. Immunohistochemistry. Intestinal Mucosa / pathology. Male. Middle Aged. Neoplasm Invasiveness. Prognosis. S100 Proteins / analysis

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  • (PMID = 20661017.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins
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19. Angiero F, Crippa R, Stefani M: Granular cells tumour in the oral cavity: report of eleven cases treated with laser surgery. Minerva Stomatol; 2006 Jul-Aug;55(7-8):423-30
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  • [Title] Granular cells tumour in the oral cavity: report of eleven cases treated with laser surgery.
  • AIM: The aim of this paper is to examine the clinical and histological feature of oral tumours of neural derivation and discuss their treatment.
  • Eight were located on the dorsum of the tongue, 2 on the lateral margin and 1 on the right buccal mucosa.
  • CONCLUSIONS: Granular cell tumour is a benign neoplasm with a tendency to relapse if not completely removed.

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  • (PMID = 17041542.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng; ita
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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20. Vieira Cury SE, Chain Hartung Habibe R, Siroteau Corrêa Pontes F, Rebelo Pontes HA, Santos De Freitas Silva B, Dos Santos Pinto JD: Oral hobnail hemangioma: case report. Minerva Stomatol; 2009 Nov-Dec;58(11-12):613-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oral hobnail hemangioma: case report.
  • Hobnail hemangioma (HH) is a rare benign vascular neoplasm reported as a distinctive small benign, solitary vascular neoplasm of the superficial and mid-dermis occurring on the face, trunk, or extremities of young or middle-aged adults.
  • The oral manifestations are quite uncommon, with only three cases reported in the English language literature.
  • The following case refers to a 38-year-old woman with a small nodule on the hard palatal mucosa.
  • Histological findings showed a biphasic growth pattern of irregularly dilated vascular structures in the superficial mucosa, lined by epithelioid endothelial cells with a hobnail appearance, with neoplastic vessels observed in deeper parts of the lesion.
  • In the oral cavity, the differential diagnosis includes hemangioma, melanoma, and Kaposi's sarcoma, whose clinical and histological features may be confused with those of HH.
  • [MeSH-major] Hemangioma / pathology. Mouth Mucosa / pathology. Palatal Neoplasms / pathology. Palate, Hard / pathology

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  • (PMID = 20027132.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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21. Prado JD, Andrade RG, Silva-Sousa YT, Andrade MF, Soares FA, Perez DE: Nerve sheath myxoma of the gingiva: report of a rare case and review of the literature. J Periodontol; 2007 Aug;78(8):1639-43
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  • BACKGROUND: Nerve sheath myxoma (NSM) is an extremely rare benign neoplasm in the oral cavity.
  • This paper describes the first case, to our knowledge, of NSM in the gingival mucosa of an 84-year-old female patient.
  • METHODS: Intraoral examination revealed a painless and well-defined nodule in the lingual gingival mucosa of the right mandibular lateral incisor, which measured approximately 1.0 cm in diameter.
  • CONCLUSION: Although NSM is an extremely rare oral tumor, it should be considered in the clinical differential diagnosis of gingival nodules.

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  • (PMID = 17668985.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S100 Proteins; 0 / Vimentin
  • [Number-of-references] 28
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22. Driemel O, Dahse R, Berndt A, Pistner H, Hakim SG, Zardi L, Reichert TE, Kosmehl H: High-molecular tenascin-C as an indicator of atypical cells in oral brush biopsies. Clin Oral Investig; 2007 Mar;11(1):93-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High-molecular tenascin-C as an indicator of atypical cells in oral brush biopsies.
  • This study investigated whether hm tn-C is a suitable indicator of atypical cells with invasive potential in oral brush biopsies.
  • One hundred fifty nine consecutive oral brush biopsies with histopathological diagnoses were analysed for the identification of atypical cells.
  • Conventional cytology produced four false-positives when identifying atypical cells in brush biopsies of inflammatory/benign hyperproliferative mucosa (specificity 96%), while 10 in 52 carcinomas and three of eight recurrences were not identified (sensitivity 78%).
  • The positive and negative predictive values were 92 and 88% for conventional cytology vs 98 and 97% for the dual assay. (1) A 95%-sensitivity proves hm tn-C assisted conventional cytology to be a suitable means of identifying atypical cells in oral brush biopsies. (2) The positive (98%) and negative (97%) predictive values obtained approximate hm tn-C assisted conventional cytology to laminin-5 (100/97%).
  • [MeSH-minor] Epithelial Cells / pathology. Humans. Immunoenzyme Techniques. Mouth Mucosa / pathology. Neoplasm Invasiveness / pathology. Prospective Studies. Sensitivity and Specificity

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  • (PMID = 17111122.001).
  • [ISSN] 1432-6981
  • [Journal-full-title] Clinical oral investigations
  • [ISO-abbreviation] Clin Oral Investig
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tenascin
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23. Gondivkar SM, Indurkar A, Degwekar S, Bhowate R: Primary oral malignant melanoma--a case report and review of the literature. Quintessence Int; 2009 Jan;40(1):41-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary oral malignant melanoma--a case report and review of the literature.
  • Malignant melanoma is a neoplasm of melanocytic origin that arises from a benign melanocytic lesion or de novo from melanocytes within otherwise normal mucosa or skin.
  • Although it comprises 1.3% of all cancers, malignant melanoma of the oral cavity accounts for only 0.2% to 8.0% of all reported melanomas.
  • Oral malignant melanoma has an extremely poor prognosis.
  • For prevention of oral mucosal melanomas, any solitary pigmentation that has no obvious explanation should be always biopsied.
  • [MeSH-minor] Adult. Humans. Male. Maxilla / surgery. Neoplasm Staging

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  • (PMID = 19159022.001).
  • [ISSN] 1936-7163
  • [Journal-full-title] Quintessence international (Berlin, Germany : 1985)
  • [ISO-abbreviation] Quintessence Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 19
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24. Capodiferro S, Loiudice AM, Pilolli G, Lajolo C, Giuliani M, Maiorano E, Favia G: Diode laser excision of chondroid lipoma of the tongue with microscopic (conventional and confocal laser scanning) analysis. Photomed Laser Surg; 2009 Aug;27(4):683-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: We describe a case of chondroid lipoma of the oral mucosa, which represents an unusual histological type of oral lipoma.
  • BACKGROUND DATA: Lipomas represent 0.1-5% of all benign oral neoplasms.
  • CONCLUSION: We maintain that the diode laser is a useful electromedical device for surgery on both benign and malignant oral lesions, though good practice is mandatory in order to apply the best parameters to the clinical situation.
  • When the preoperative biopsy is not performable because of small dimension, as in the reported case, surgical excision of all nodular lesions of the oral mucosa should be performed with lateral and deep margins distant from the central lesion.
  • This prevents possible complications related to a possible final diagnosis of malignant neoplasm; in fact, the differential diagnosis in the reported case also included liposarcoma.

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  • (PMID = 19694511.001).
  • [ISSN] 1557-8550
  • [Journal-full-title] Photomedicine and laser surgery
  • [ISO-abbreviation] Photomed Laser Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Subhashraj K, Balanand S, Pajaniammalle S: Ancient schwannoma arising from mental nerve. A case report and review. Med Oral Patol Oral Cir Bucal; 2009 Jan;14(1):E12-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Schwannoma is an intraoral rare, benign neoplasm derived from the nerve sheath of peripheral nerves.
  • Ancient schwannoma of the head and neck region is relatively uncommon and very few cases had been reported in the oral cavity.
  • Examination revealed a 30 x 25 mm firm, strawberry-like mass in the periapical region of the left lower first premolar, extending anteriorly to the canine and posteriorly to the first molar, obliterating the buccal vestibule, with an intact overlying mucosa.

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  • (PMID = 19114949.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 11
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26. Jayanthi JL, Mallia RJ, Shiny ST, Baiju KV, Mathews A, Kumar R, Sebastian P, Madhavan J, Aparna GN, Subhash N: Discriminant analysis of autofluorescence spectra for classification of oral lesions in vivo. Lasers Surg Med; 2009 Jul;41(5):345-52
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  • [Title] Discriminant analysis of autofluorescence spectra for classification of oral lesions in vivo.
  • BACKGROUND AND OBJECTIVES: Low survival rate of individuals with oral cancer emphasize the significance of early detection and treatment.
  • Optical spectroscopic techniques are under various stages of development for diagnosis of epithelial neoplasm.
  • This study evaluates the potential of a multivariate statistical algorithm to classify oral mucosa from autofluorescence spectral features recorded in vivo.
  • RESULTS: Autofluorescence spectra of healthy volunteers consists of a broad emission at 500 nm that is characteristic of endogenous fluorophores, whereas in malignant lesions three additional peaks are observed at 635, 685, and 705 nm due to the accumulation of porphyrins in oral lesions.
  • It was observed that classification design based on discriminant function scores obtained by LDA-LOO method was able to differentiate pre-malignant dysplasia from squamous cell carcinoma (SCC), benign hyperplasia from dysplasia and hyperplasia from normal with overall sensitivities of 86%, 78%, and 92%, and specificities of 90%, 100%, and 100%, respectively.
  • CONCLUSIONS: The application of LDA-LOO method on the autofluorescence spectra recorded during a clinical trial in patients was found suitable to discriminate oral mucosal alterations during tissue transformation towards malignancy with improved diagnostic accuracies.

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  • (PMID = 19533763.001).
  • [ISSN] 1096-9101
  • [Journal-full-title] Lasers in surgery and medicine
  • [ISO-abbreviation] Lasers Surg Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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27. Daniels JS: Granular cell tumour of tongue: A case report. Saudi Dent J; 2009 Jul;21(2):75-8
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  • Granular cell tumour, also known as Abrikossoff tumour, is a relatively uncommon benign neoplasm, which is more commonly found in females in the 4th to 6th decades of life even though it can occur in all ages.
  • Most of the intraoral lesions occur on the tongue, usually on the lateral aspect, followed by the buccal mucosa and hard palate.
  • Although majority of granular cell tumours are benign, some are clinically aggressive and a few frankly malignant forms have been reported.
  • Some benign lesions exhibit surface ulcerations and this clinical appearance, combined with the overlying pseudoepitheliomatous hyperplasia, seen histologically, may lead to misdiagnosis of malignancy if adequate biopsy material was not taken.

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  • (PMID = 23960463.001).
  • [ISSN] 1013-9052
  • [Journal-full-title] The Saudi dental journal
  • [ISO-abbreviation] Saudi Dent J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Other-IDs] NLM/ PMC3722994
  • [Keywords] NOTNLM ; Dorsum of posterior one-third of tongue / Granular cell tumour / Lingual thyroid / Pseudoepitheliomatous hyperplasia / Squamous cell carcinoma of tongue
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28. Capodiferro S, Maiorano E, Scarpelli F, Favia G: Fibrolipoma of the lip treated by diode laser surgery: a case report. J Med Case Rep; 2008;2:301
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  • This approach allowed adequate resection of the neoplasm with minimal damage to the adjacent tissues, thus reducing post-surgical scarring.
  • CONCLUSION: Diode laser surgery for the treatment of benign lesions of the oral mucosa appears to be a convenient alternative to conventional blade surgery and has proved to be effective for the excision of fibrolipoma of the lip.

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  • [Cites] Oral Dis. 2004 Nov;10(6):398-400 [15533218.001]
  • [Cites] Int J Oral Maxillofac Surg. 2003 Feb;32(1):49-53 [12653233.001]
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  • (PMID = 18789134.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2547114
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29. Adeyemi BF, Ogun GO, Akang EE: Retrospective analysis of intra-oral salivary gland tumours in Ibadan, Nigeria. West Afr J Med; 2010 Mar-Apr;29(2):98-103
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  • [Title] Retrospective analysis of intra-oral salivary gland tumours in Ibadan, Nigeria.
  • RESULTS: Of a total of 309 neoplasms of salivary gland origin, 92 were from the intra-oral minor salivary glands constituting 4.5% of head and neck neoplasm.
  • Fifty-seven (62%) cases were malignant, while 35 (38%) were benign.
  • About 73% of the salivary gland neoplasms affected the palate, followed by the buccal mucosa (16.3%).
  • Patients with malignant neoplasms were about 10 years older than those with benign tumours (p=0.012).

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  • (PMID = 20544634.001).
  • [ISSN] 0189-160X
  • [Journal-full-title] West African journal of medicine
  • [ISO-abbreviation] West Afr J Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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30. Colombo P, Tondulli L, Masci G, Muzza A, Rimassa L, Petrella D, Santoro A: Oral ulcer as an exclusive sign of gastric cancer: report of a rare case. BMC Cancer; 2005;5:117
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  • [Title] Oral ulcer as an exclusive sign of gastric cancer: report of a rare case.
  • BACKGROUND: The oral cavity is a rare but occasional target for metastases, which may masquerade as various benign and inflammatory lesions, and sometimes also be asymptomatic.
  • Oral metastatic lesions have been described in various cancers, particularly lung, breast and kidney carcinoma.
  • CASE PRESENTATION: We here describe an uncommon case of a hard palate mucosa and gingival metastasis from gastric carcinoma that was originally diagnosed as a periodontal disease.
  • CONCLUSION: An occult carcinoma of the stomach may rarely metastasise to the oral cavity even as a first and exclusive manifestation; it is important to bear this possibility in mind because such conditions may mimic a benign disease.
  • [MeSH-minor] Biopsy. Carcinoma / pathology. Cell Differentiation. Fatal Outcome. Female. Humans. Immunohistochemistry. Middle Aged. Mouth Mucosa / pathology. Neoplasm Metastasis. Palate, Hard / pathology

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  • [Cites] J Periodontol. 1976 Jun;47(6):358-60 [1064724.001]
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  • (PMID = 16171522.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1242220
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31. Moreira PR, Guimarães MM, Guimarães AL, Diniz MG, Gomes CC, Brito JA, Gomez RS: Methylation of P16, P21, P27, RB1 and P53 genes in odontogenic keratocysts. J Oral Pathol Med; 2009 Jan;38(1):99-103
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  • BACKGROUND: Odontogenic keratocyst (OKC) is a benign neoplasm with an aggressive clinical behavior and a high recurrence rate.
  • METHODS: Methylation-specific polymerase chain reaction (MSP) was used to evaluate the presence of methylation in 10 samples of OKCs, 10 samples of dental follicles and six samples of normal mucosa.
  • High frequency of P27 methylation (90%) was observed in dental follicles, however, some OKC lesions (10%) and normal mucosa samples (33%) were also methylated.
  • [MeSH-minor] Adolescent. Adult. Child. Cyclin-Dependent Kinase Inhibitor p21 / genetics. Cyclin-Dependent Kinase Inhibitor p27 / genetics. Dental Sac / metabolism. Epigenesis, Genetic / genetics. Female. Genes, p16. Genes, p53. Humans. Male. Mouth Mucosa / metabolism. Promoter Regions, Genetic / genetics. Retinoblastoma Protein / genetics. Young Adult

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  • (PMID = 19192054.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CDKN1A protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Retinoblastoma Protein; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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32. Lin C, Li J, Lu N: [Analysis of 2161 cases of neoplasm in oral maxillofacial region in Xinjiang]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2010 Sep;45(9):553-5
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  • [Title] [Analysis of 2161 cases of neoplasm in oral maxillofacial region in Xinjiang].
  • OBJECTIVE: To investigate the incidence and constituent characteristic of neoplasm in oromaxillo-facial region in Xinjiang.
  • METHODS: A total of 2161 patients with benign or malignant oral-maxillofacial tumors diagnosed in Department of Dentofacial Surgery of the First Affiliated Hospital of Xinjiang Medical College from 1995 to 2009 were analyzed retrospectively.
  • RESULTS: Of the 2161 cases, 58.49% (1264/2161) was benign tumors, 33.13% (716/2161) malignant tumors, and 8.38% (181/2161) tumor-like lesions.
  • The most common benign tumors were pleomorphic adenoma, hemangioma, papilloma, adenolymphoma and ameloblastoma.
  • The most common sites of malignant tumors were tongue, lip, parotiod gland and buccal mucosa.
  • CONCLUSIONS: The common pathological type of oral and maxillofacial benign neoplasm and the most common sites of malignancy in Xinjiang region were similar to those of other places inside and outside the country.
  • [MeSH-minor] Adenolymphoma. Adenoma, Pleomorphic. Ameloblastoma. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. China / epidemiology. Face. Humans. Incidence. Mouth Mucosa. Odontogenic Tumors. Retrospective Studies. Salivary Gland Neoplasms

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  • (PMID = 21122451.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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33. Sun ZJ, Zhang L, Zhang WF, Alsharif MJ, Chen XM, Zhao YF: Epithelioid hemangioma in the oral mucosa: a clinicopathological study of seven cases and review of the literature. Oral Oncol; 2006 May;42(5):441-7
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  • [Title] Epithelioid hemangioma in the oral mucosa: a clinicopathological study of seven cases and review of the literature.
  • To investigate the clinicopathological characteristics and biologic behavior of epithelioid hemangioma in oral mucosa, the clinical features and pathological findings of seven cases of epithelioid hemangioma were reviewed, and all sections were examined by immunohistochemistry.
  • Epithelioid hemangioma is a benign vascular anomaly, and has close relationship with local trauma.
  • [MeSH-minor] Adult. Aged. Antigens, CD34 / metabolism. Child. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Mouth / injuries. Mouth Mucosa. Neoplasm Proteins / metabolism. Retrospective Studies. Vimentin / metabolism. von Willebrand Factor / metabolism

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  • (PMID = 16266821.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Neoplasm Proteins; 0 / Vimentin; 0 / von Willebrand Factor
  • [Number-of-references] 34
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34. Saran R, Tiwari RK, Reddy PP, Ahuja YR: Risk assessment of oral cancer in patients with pre-cancerous states of the oral cavity using micronucleus test and challenge assay. Oral Oncol; 2008 Apr;44(4):354-60
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  • [Title] Risk assessment of oral cancer in patients with pre-cancerous states of the oral cavity using micronucleus test and challenge assay.
  • Oral cancer is a common malignancy, ranking first among all cancers in Western and Asian countries.
  • Oral cancer is preceded by some benign lesions or conditions, which are termed pre-cancerous.
  • [MeSH-minor] Adolescent. Adult. Aged. Chromosome Aberrations. Comet Assay / methods. DNA Damage. DNA Repair. DNA, Neoplasm / genetics. Disease Progression. Female. Humans. Leukocytes / drug effects. Leukocytes / pathology. Male. Methylnitronitrosoguanidine / pharmacology. Micronucleus Tests / methods. Middle Aged. Mouth Mucosa / pathology. Risk Assessment / methods

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  • [CommentIn] Oral Oncol. 2008 Jul;44(7):716-7 [18381248.001]
  • (PMID = 17936677.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 12H3O2UGSF / Methylnitronitrosoguanidine
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35. Canjuga I, Mravak-Stipetić M, Kopić V, Galić J: Oral acanthosis nigricans: case report and comparison with literature reports. Acta Dermatovenerol Croat; 2008;16(2):91-5
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  • [Title] Oral acanthosis nigricans: case report and comparison with literature reports.
  • Acanthosis nigricans (AN) is a rare condition which may affect oral cavity.
  • There are two forms of AN: benign and malignant.
  • Benign AN may be hereditary, or may be related to systemic diseases or drugs.
  • This case report is based on a case of a 78-year-old woman suffering from invasive bladder papillary transitional cell carcinoma accompanied by extensive papillomatous areas of normal mucosal color and soft consistency involving the lips, buccal mucosa and hard palate.
  • Oral lesions occurred after the tumor had been diagnosed, i.e. after third operation for tumor recurrence.
  • The fifth operation for tumor recurrence resulted in slight improvement of oral changes.
  • It is concluded that the severity of oral changes is in correlation with tumor progression.
  • The occurrence of oral lesions may be an indicator of tumor progression.
  • [MeSH-minor] Aged. Disease Progression. Female. Humans. Neoplasm Recurrence, Local / surgery. Reoperation. Severity of Illness Index

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  • (PMID = 18541106.001).
  • [ISSN] 1330-027X
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Croatia
  • [Number-of-references] 20
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36. Eversole LR: Cellular angiofibroma of oral mucosa: report of two cases. Head Neck Pathol; 2009 Jun;3(2):136-9
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  • [Title] Cellular angiofibroma of oral mucosa: report of two cases.
  • Cellular angiofibroma is a benign vascular neoplasm that typically arises in the vulva, perineal, and paratesticular region.
  • This represents the first reported instances of cellular angiofibroma in the oral cavity.
  • [MeSH-major] Angiofibroma / pathology. Mouth Mucosa / pathology. Mouth Neoplasms / pathology

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  • (PMID = 19644547.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Angiofibroma / Hemangioma / Mesenchymal tumor / Oral cavity / Vascular tumor
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37. Nowaczewska K, Wójtowicz P, Kukwa A, Ratajczak J, Tulibacki M: [Respiratory papillomatosis--new methods of treatment]. Otolaryngol Pol; 2010 Jan-Feb;64(1):31-6
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  • The most common location in head and neck is larynx, palatine tonsils and arches of palate, uvula and mucosa oral and nasal cavity.
  • The disease is benign but recurrent.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Drug Administration Schedule. Female. Humans. Injections, Intralesional. Male. Middle Aged. Neoplasm Staging. Poland. Remission Induction. Treatment Outcome. Young Adult

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  • (PMID = 20476590.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / Organophosphonates; 8J337D1HZY / Cytosine; JIL713Q00N / cidofovir
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38. Tosios KI, Koutlas IG, Kyriakopoulos VF, Balta M, Theologie-Lygidakis N, Vardas E, Iatrou I: Time to abandon the term angiomyolipoma for non-PEComatous angiomyomatous (or angiomatous) oral tumors with adipocytes. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Oct;110(4):492-7
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  • [Title] Time to abandon the term angiomyolipoma for non-PEComatous angiomyomatous (or angiomatous) oral tumors with adipocytes.
  • Angiomyolipoma (AML) is the most common benign mesenchymal neoplasm of the kidneys with well-established clinical and morphological features.
  • The oral and maxillofacial pathology literature contains several examples that identify angiomyomatous proliferations of the oral mucosa that contain an adipocytic component as analogous to classic renal AMLs although they differ significantly in their immunohistochemical phenotype.
  • Herein, through review of the pertinent oral pathology literature and the detailed description of 2 lesions, one an oral angiomyoma with an adipocytic component and the other an apparently hamartomatous angioleiomyomatous proliferation with adipocytes, we provide, in our opinion, a solid argument against the use of the term AML for non-PEComatous oral tumors.

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  • [Copyright] Copyright © 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20674420.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Desmin; 0 / S100 Proteins; 0 / von Willebrand Factor
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39. Eguia A, Uribarri A, Gay Escoda C, Crovetto MA, Martínez-Conde R, Aguirre JM: Granular cell tumor: report of 8 intraoral cases. Med Oral Patol Oral Cir Bucal; 2006 Aug;11(5):E425-8
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  • Granular cell tumor (GCT) is an uncommon neoplasm of controversial origin that can appear in any corporal localization, including the orofacial region.
  • Although aggressive and malignant variants of this neoplasm have been described, most of GCTs are benign.
  • In spite of the amount of research, the etiology of this neoplasm remains unclear and its histogenesis and its possible muscular, connective or neural origin has been broadly debated.
  • In this paper 8 oral cases are presented, corresponding to 5 women and 3 men, with a mean age of 36.1 years old and a mean time of evolution of the lesions of 8.3 months.
  • The main clinicopathologic and diagnostic features of this neoplasm are reviewed and discussed.
  • [MeSH-minor] Adolescent. Adult. Female. Gingival Neoplasms / pathology. Humans. Male. Middle Aged. Mouth Mucosa / pathology. Tongue Neoplasms / pathology

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  • (PMID = 16878061.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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40. Studart-Soares EC, Costa FW, Sousa FB, Alves AP, Osterne RL: Oral lipomas in a Brazilian population: a 10-year study and analysis of 450 cases reported in the literature. Med Oral Patol Oral Cir Bucal; 2010 Sep;15(5):e691-6
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  • [Title] Oral lipomas in a Brazilian population: a 10-year study and analysis of 450 cases reported in the literature.
  • OBJECTIVES: Lipomas are common benign mesenchymal neoplasms that rarely occur in the oral cavity and correspond to less than 4.4% of all benign oral soft tissue tumors.
  • This study describes the clinical, radiological and histological features of cases of oral lipomas seen over a period of 10 years and compared the findings with those reported in the literature.
  • STUDY DESIGN: All cases of oral lipomas seen between 1999 and 2009 were retrieved from the archives of the Stomatology Division of the Federal University of Ceará, Brazil.
  • The specific sites involved were the oral mucosa (n=5), vestibule (n=3), gingiva (n=1), and retromolar region (n=1).
  • The findings were compared with 450 cases of oral lipomas reported in the literature.
  • CONCLUSIONS: Lipomas continue to be an uncommon neoplasm of the oral cavity.

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  • (PMID = 20383107.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Spain
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41. Gkoulioni V, Eleftheriadou A, Yiotakis I, Ferekidou E, Chrisovergis A, Lazaris ACh, Kandiloros D: The efficacy of imiquimod on dysplastic lesions of the oral mucosa: an experimental model. Anticancer Res; 2010 Jul;30(7):2891-6
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  • [Title] The efficacy of imiquimod on dysplastic lesions of the oral mucosa: an experimental model.
  • AIM: To study the potent efficacy of the immunomodulatory agent imiquimod when applied on dysplastic lesions of the oral mucosa.
  • MATERIALS AND METHODS: Carcinogen (DMBA) was applied to the mucosa of the left buccal pouch of 26 male Wistar rats for 8 weeks, until dysplastic lesions were observed and histologically diagnosed.
  • In one case, a well-differentiated squamous cell carcinoma was converted to a papilloma-like squamous neoplasm with a benign morphology.
  • CONCLUSION: Our results indicate that imiquimod may be effective in treatment of precancerous lesions of the oral mucosa and thus inhibit the progress of carcinogenesis.
  • [MeSH-minor] 9,10-Dimethyl-1,2-benzanthracene. Animals. Antineoplastic Agents / pharmacology. Carcinogens. Carcinoma, Squamous Cell / chemically induced. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / pathology. Male. Mouth Mucosa / drug effects. Mouth Mucosa / pathology. Rats. Rats, Wistar

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  • (PMID = 20683029.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antineoplastic Agents; 0 / Carcinogens; 57-97-6 / 9,10-Dimethyl-1,2-benzanthracene; 99011-02-6 / imiquimod
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42. Folk GS, Williams SB, Foss RB, Fanburg-Smith JC: Oral and maxillofacial sclerosing epithelioid fibrosarcoma: report of five cases. Head Neck Pathol; 2007 Sep;1(1):13-20
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  • [Title] Oral and maxillofacial sclerosing epithelioid fibrosarcoma: report of five cases.
  • Lesions involving the oral and maxillofacial region (OMFR) and intraosseous examples are rare.
  • The OMF Pathology Department Registry was searched for cases coded from 1990 to the present as "SEF," "fibrosarcoma not otherwise specified" or "neoplasm of uncertain histiogenesis."
  • Tumor location included the infra-temporal fossa, buccal mucosa (recurrence extending into bone), anterior mandible (intraosseous primary, focally extending into soft tissue), and left parotid and submandibular gland (with metaplastic bone) regions.
  • The differential diagnosis for these tumors in this site includes sclerosing carcinoma, Ewing/PNET, osteosarcoma, osteoblastoma, and benign and malignant myoepithelial salivary gland tumors.
  • [MeSH-minor] Adult. Apoptosis. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Leiomyoma / diagnosis. Male. Middle Aged. Sclerosis. Solitary Fibrous Tumors / diagnosis. Young Adult

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  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • [ErratumIn] Head Neck Pathol. 2013 Mar;7(1):103
  • (PMID = 20614275.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807507
  • [Keywords] NOTNLM ; Maxillofacial / Oral / Sarcoma / Sclerosing epithelioid fibrosarcoma
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43. Bologna-Molina R, Mosqueda-Taylor A, Lopez-Corella E, Almeida OP, Carrasco-Daza D, Garcia-Vazquez F, Farfan-Morales JE, Irigoyen-Camacho ME, Damián-Matsumura P: Syndecan-1 (CD138) and Ki-67 expression in different subtypes of ameloblastomas. Oral Oncol; 2008 Aug;44(8):805-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ameloblastoma is the most frequent odontogenic tumor and is considered a benign, but locally invasive, neoplasm with variable clinico-pathological expression.
  • [MeSH-major] Ameloblastoma / metabolism. Ki-67 Antigen / metabolism. Neoplasm Proteins / metabolism. Syndecan-1 / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Down-Regulation. Female. Gene Expression. Humans. Immunohistochemistry. Male. Middle Aged. Mouth Mucosa / metabolism. Tooth Germ / metabolism. Young Adult

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  • (PMID = 18207448.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Neoplasm Proteins; 0 / Syndecan-1
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