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1. Rubin AI, Yassaee M, Johnson W, Elenitsas R, Zaladonis J Jr, Seykora JT: Multiple cutaneous sclerosing perineuriomas: an extensive presentation with involvement of the bilateral upper extremities. J Cutan Pathol; 2009 Oct;36 Suppl 1:60-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A perineurioma is a benign peripheral nerve sheath neoplasm thought to be derived from cells of the perineurium, the cellular sheathing of peripheral nerve fascicles.
  • [MeSH-major] Neoplasms, Multiple Primary / pathology. Nerve Sheath Neoplasms / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19187114.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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2. Koch P, Petri M, Paradowska A, Stenzinger A, Sturm K, Steger K, Wimmer M: PTPIP51 mRNA and protein expression in tissue microarrays and promoter methylation of benign prostate hyperplasia and prostate carcinoma. Prostate; 2009 Dec 1;69(16):1751-62
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  • [Title] PTPIP51 mRNA and protein expression in tissue microarrays and promoter methylation of benign prostate hyperplasia and prostate carcinoma.
  • In this study the expression of PTPIP51 and its in vitro interaction partners was investigated in human benign prostate hyperplasia (BPH) and in prostate carcinoma (PCa).
  • A stronger expression was present in nerve fibers, particularly in PCa, in immune cells and in smooth muscle and endothelial cells of vessels of BPH and PCa.
  • [MeSH-minor] Aged. CpG Islands / genetics. Endothelial Cells / metabolism. Epithelium / metabolism. Humans. Immune System / metabolism. Immune System / pathology. Male. Microarray Analysis. Middle Aged. Muscle, Smooth, Vascular / metabolism. Muscle, Smooth, Vascular / pathology. Myocytes, Smooth Muscle / metabolism. Neoplasm Invasiveness. Nerve Fibers / metabolism. Prostate / blood supply. Prostate / innervation. Prostate / metabolism. Tissue Distribution

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  • [Copyright] Copyright 2009 Wiley-Liss, Inc.
  • (PMID = 19691131.001).
  • [ISSN] 1097-0045
  • [Journal-full-title] The Prostate
  • [ISO-abbreviation] Prostate
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mitochondrial Proteins; 0 / RNA, Messenger; EC 3.1.3.48 / FAM82A2 protein, human; EC 3.1.3.48 / Protein Tyrosine Phosphatases
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3. Sabah M, Cummins R, Leader M, Kay E: Leiomyosarcoma and malignant fibrous histiocytoma share similar allelic imbalance pattern at 9p. Virchows Arch; 2005 Mar;446(3):251-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The frequency of allelic imbalance at different loci on chromosome 9p was analysed in LMS and MFH and then compared with values previously examined in synovial sarcoma and malignant peripheral nerve sheath tumour.
  • Alterations of this locus were very rare in synovial sarcoma and malignant peripheral nerve sheath tumours and were absent in cutaneous LMS and angiomatoid fibrous histiocytoma.
  • [MeSH-major] Chromosomes, Human, Pair 9 / genetics. DNA, Neoplasm / genetics. Histiocytoma, Benign Fibrous / genetics. Leiomyosarcoma / genetics. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Allelic Imbalance. Humans. Immunohistochemistry. Loss of Heterozygosity. Microsatellite Repeats. Nerve Sheath Neoplasms / genetics. Polymerase Chain Reaction. Sarcoma, Synovial / genetics

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  • (PMID = 15731925.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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4. Tchoghandjian A, Fernandez C, Colin C, El Ayachi I, Voutsinos-Porche B, Fina F, Scavarda D, Piercecchi-Marti MD, Intagliata D, Ouafik L, Fraslon-Vanhulle C, Figarella-Branger D: Pilocytic astrocytoma of the optic pathway: a tumour deriving from radial glia cells with a specific gene signature. Brain; 2009 Jun;132(Pt 6):1523-35
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  • These tumours affect preferentially the cerebellum (benign clinical course) and the optic pathway, especially the hypothalamo-chiasmatic region (poor prognosis).
  • [MeSH-major] Astrocytoma / diagnosis. Optic Nerve Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Astrocytes / metabolism. Cell Proliferation. Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / genetics. Cerebellar Neoplasms / pathology. Child. Child, Preschool. DNA, Neoplasm / genetics. Diagnosis, Differential. Gene Expression Profiling / methods. Gene Expression Regulation, Neoplastic. Humans. Hypothalamus / metabolism. Infant. Middle Aged. Neoplastic Stem Cells / pathology. Neuroglia / pathology. Oligonucleotide Array Sequence Analysis / methods. Optic Chiasm / cytology. Optic Chiasm / embryology. Optic Chiasm / metabolism. Reverse Transcriptase Polymerase Chain Reaction / methods. Up-Regulation. Vimentin / metabolism. Young Adult

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  • (PMID = 19336457.001).
  • [ISSN] 1460-2156
  • [Journal-full-title] Brain : a journal of neurology
  • [ISO-abbreviation] Brain
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Vimentin
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5. Subramanian S, Thayanithy V, West RB, Lee CH, Beck AH, Zhu S, Downs-Kelly E, Montgomery K, Goldblum JR, Hogendoorn PC, Corless CL, Oliveira AM, Dry SM, Nielsen TO, Rubin BP, Fletcher JA, Fletcher CD, van de Rijn M: Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumours. J Pathol; 2010 Jan;220(1):58-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumours.
  • Malignant peripheral nerve sheath tumours (MPNSTs) are aggressive soft tissue tumours that occur either sporadically or in patients with neurofibromatosis type 1.
  • The malignant transformation of the benign neurofibroma to MPNST is incompletely understood at the molecular level.
  • We have determined the gene expression signature for benign and malignant PNSTs and found that the major trend in malignant transformation from neurofibroma to MPNST consists of the loss of expression of a large number of genes, rather than widespread increase in gene expression.
  • Subsequent microRNA profiling of benign and malignant PNSTs indicated a relative down-regulation of miR-34a in most MPNSTs compared to neurofibromas.
  • Collectively, our findings suggest that deregulation of miRNAs has a potential role in the malignant transformation process in peripheral nerve sheath tumours.
  • [MeSH-major] Genes, p53. MicroRNAs / metabolism. Nerve Sheath Neoplasms / genetics. RNA, Neoplasm / metabolism
  • [MeSH-minor] Adult. Apoptosis / genetics. Cell Adhesion / genetics. Cell Proliferation. Cluster Analysis. Down-Regulation. Female. Gene Expression Profiling / methods. Gene Expression Regulation, Neoplastic. Gene Silencing. Humans. Male. Middle Aged. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism. Neurofibroma. Oligonucleotide Array Sequence Analysis / methods. Receptor, Epidermal Growth Factor / genetics. Receptor, Epidermal Growth Factor / metabolism. Reverse Transcriptase Polymerase Chain Reaction / methods. Signal Transduction / genetics. Tumor Cells, Cultured. Tumor Suppressor Protein p53 / metabolism


6. Schöniger S, Summers BA: Localized, plexiform, diffuse, and other variants of neurofibroma in 12 dogs, 2 horses, and a chicken. Vet Pathol; 2009 Sep;46(5):904-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In humans, neurofibroma and schwannoma are distinct entities within the group of benign peripheral nerve sheath tumors.
  • In the veterinary literature, these tumors are often classified together simply as benign peripheral nerve sheath tumors, and diagnostic criteria for their subclassification are not well established.
  • We describe peripheral nerve sheath tumors with microscopic, immunohistologic, and ultrastructural features similar to those in subtypes of human neurofibroma in 12 dogs, 2 horses, and 1 chicken.
  • The canine tumors were located in the skin, peripheral nerve, tongue, and large intestine.
  • The chicken was a mature white Leghorn chicken with an ocular neoplasm.
  • This report will allow a more discriminating classification of benign peripheral nerve sheath tumors and probably has a bearing on epidemiology, pathogenesis and prognosis.

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  • (PMID = 19429995.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Hong KH, Yang YS: Intraoral approach for the treatment of submandibular salivary gland mixed tumors. Oral Oncol; 2008 May;44(5):491-5
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  • Pleomorphic adenoma represents a most common benign neoplasm of major salivary glands.
  • Most occurrences of this benign tumor in the submandibular gland have been treated surgically without difficulty via transcervical approach.
  • However, a few clinical problems in the transcervical approach have been mentioned, such as nerve injury or aesthetic scaring.
  • Early postoperative morbidity developed, such as a temporary paresis of lingual nerve and a temporary limitation of tongue movement, but recovered within a short-term period.
  • We propose that the benign mixed tumor of the submandibular gland could be removed easily via intraoral route without an external scar or nerve injury.
  • [MeSH-minor] Adolescent. Adult. Cicatrix / prevention & control. Facial Nerve Injuries / prevention & control. Female. Humans. Lingual Nerve. Male. Middle Aged. Treatment Outcome

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  • (PMID = 17827052.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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8. Gokce M: Analysis of isolated cranial nerve manifestations in patients with cancer. J Clin Neurosci; 2005 Nov;12(8):882-5
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  • [Title] Analysis of isolated cranial nerve manifestations in patients with cancer.
  • The aim of this study was to assess the underlying causes of isolated cranial nerve (CN) manifestations in cancer patients.
  • Although most of the isolated CN manifestations were due to systemic metastasis, in particular to the meninges, up to 20% were related to benign conditions.
  • [MeSH-major] Cranial Nerve Diseases / etiology. Neoplasms / complications
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Magnetic Resonance Imaging. Male. Meningeal Neoplasms / secondary. Middle Aged. Neoplasm Metastasis / pathology

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  • (PMID = 16326269.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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9. Lönnrot K, Terho M, Kähärä V, Haapasalo H, Helén P: Desmoplastic infantile ganglioglioma: novel aspects in clinical presentation and genetics. Surg Neurol; 2007 Sep;68(3):304-8; discussion 308
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Both radiological and histopathological appearances may resemble malignancy, although its clinical course is mainly benign.
  • This patient, moreover, had 2 other lesions suspected of being DIG, including a mass originating from the ophthalmic nerve.
  • [MeSH-minor] Adult. Aged. Child. Child, Preschool. Epilepsy / etiology. Follow-Up Studies. Humans. Male. Neoplasm Proteins / metabolism. Nerve Tissue Proteins / metabolism. Oncogenes / physiology. Retrospective Studies. Treatment Outcome


10. Mentzel T, Kutzner H: Reticular and plexiform perineurioma: clinicopathological and immunohistochemical analysis of two cases and review of perineurial neoplasms of skin and soft tissues. Virchows Arch; 2005 Oct;447(4):677-82
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  • Perineurioma represents a recently described and relatively rare neoplasm in the spectrum of benign peripheral nerve sheath tumours composed of perineurial cells staining immunohistochemically positive for epithelial membrane antigen (EMA).
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16133356.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CLDN1 protein, human; 0 / Claudin-1; 0 / Glucose Transporter Type 1; 0 / Membrane Proteins; 0 / Mucin-1; 0 / S100 Proteins
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11. Reis-Filho JS, Steele D, Di Palma S, Jones RL, Savage K, James M, Milanezi F, Schmitt FC, Ashworth A: Distribution and significance of nerve growth factor receptor (NGFR/p75NTR) in normal, benign and malignant breast tissue. Mod Pathol; 2006 Feb;19(2):307-19
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  • [Title] Distribution and significance of nerve growth factor receptor (NGFR/p75NTR) in normal, benign and malignant breast tissue.
  • Nerve growth factor receptor (NGFR) is a transmembrane glycoprotein without intrinsic tyrosine kinase activity, whose expression is not restricted to neural cells.
  • NGFR expression was immunohistochemically analysed in normal breast tissue and in 140 benign, biphasic and preinvasive breast lesions, in 22 tumours with myoepithelial differentiation and in two cohorts of breast cancer patients: a series of 245 invasive breast carcinomas studied with tissue microarrays and 37 high-grade invasive ductal carcinomas with basal-like immunophenotype.
  • NGFR consistently displayed membrane reactivity in myoepithelial cells arranged as a continuous layer around normal ducts and lobular units, intralobular fibroblasts, vascular adventitia and nerve bundles.
  • Myoepithelial cells of benign proliferations and pre-invasive lesions were consistently positive for NGFR.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / pathology. Nerve Tissue Proteins / analysis. Receptors, Growth Factor / analysis
  • [MeSH-minor] Carcinoma, Intraductal, Noninfiltrating / metabolism. Carcinoma, Intraductal, Noninfiltrating / pathology. Carcinoma, Lobular / metabolism. Carcinoma, Lobular / pathology. Epithelial Cells / chemistry. Epithelial Cells / pathology. Female. Fibroadenoma / metabolism. Fibroadenoma / pathology. Fibrocystic Breast Disease / metabolism. Fibrocystic Breast Disease / pathology. Humans. Immunohistochemistry. Keratin-14. Keratin-5. Keratin-6. Keratins / analysis. Myoepithelioma / metabolism. Myoepithelioma / pathology. Neoplasm Invasiveness. Receptors, Estrogen / analysis. Receptors, Nerve Growth Factor. Receptors, Progesterone / analysis. Survival Analysis

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  • (PMID = 16424897.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / KRT14 protein, human; 0 / KRT5 protein, human; 0 / KRT6A protein, human; 0 / KRT6B protein, human; 0 / KRT6C protein, human; 0 / Keratin-14; 0 / Keratin-5; 0 / Keratin-6; 0 / NGFR protein, human; 0 / Nerve Tissue Proteins; 0 / Receptors, Estrogen; 0 / Receptors, Growth Factor; 0 / Receptors, Nerve Growth Factor; 0 / Receptors, Progesterone; 68238-35-7 / Keratins
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12. Avninder S, Ramesh V, Vermani S: Benign nerve sheath myxoma (myxoid neurothekeoma) in the leg. Dermatol Online J; 2007;13(2):14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign nerve sheath myxoma (myxoid neurothekeoma) in the leg.
  • Myxoid neurothekeoma is a rare benign cutaneous neoplasm of nerve sheath origin and is also called as benign nerve sheath myxoma.

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  • (PMID = 17498433.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Laskin WB, Fetsch JF, Lasota J, Miettinen M: Benign epithelioid peripheral nerve sheath tumors of the soft tissues: clinicopathologic spectrum of 33 cases. Am J Surg Pathol; 2005 Jan;29(1):39-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign epithelioid peripheral nerve sheath tumors of the soft tissues: clinicopathologic spectrum of 33 cases.
  • Benign epithelioid peripheral nerve sheath tumors (BEPNSTs) have not been fully characterized, and their relationship to conventional schwannoma and neurofibroma has not been satisfactorily established.
  • Immunohistochemical reactivity for Schwann cell-related markers in tumor cells included S-100 protein (20 of 20 cases), collagen type IV (10 of 10), laminin (8 of 8), nerve growth factor receptor, p75(7 of 8), CD57 (6 of 9), and glial fibrillary acidic protein (8 of 15).
  • [MeSH-major] Epithelioid Cells / pathology. Nerve Sheath Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Child. Child, Preschool. DNA, Neoplasm / analysis. Female. Humans. Immunoenzyme Techniques. Loss of Heterozygosity. Male. Middle Aged. Mitotic Index. Neurofibromin 1 / genetics. Neurofibromin 1 / metabolism. Neurofibromin 2 / genetics. Neurofibromin 2 / metabolism. Polymerase Chain Reaction

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  • (PMID = 15613855.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Neurofibromin 1; 0 / Neurofibromin 2
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14. Asari R, Niederle BE, Scheuba C, Riss P, Koperek O, Kaserer K, Niederle B: Indeterminate thyroid nodules: a challenge for the surgical strategy. Surgery; 2010 Sep;148(3):516-25
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  • First step lymphadenectomy (lymph node dissection along the recurrent laryngeal nerve before removing the thyroid lobe) was performed in 142 patients documenting 10 nodal metastases.
  • Comparing benign and malignant ITN, no association was found for sex (P = .17), age (P = 1.0), tumor sizes (P = .33, P = .12, P = .19 for < or =30 mm, < or =40 mm, and < or =50 mm, respectively), or thyroid function (P = .26).
  • No permanent hypoparathyroidism or recurrent laryngeal nerve palsy was observed postoperatively.
  • [MeSH-minor] Adult. Female. Humans. Laryngeal Nerves / pathology. Laryngeal Nerves / surgery. Lymph Node Excision. Male. Middle Aged. Neoplasm Metastasis / pathology. Prognosis. Prospective Studies. Recurrence. Retrospective Studies. Thyroid Function Tests. Thyroidectomy

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20338609.001).
  • [ISSN] 1532-7361
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Cheong JH, Kim JM, Bak KH, Kim CH, Oh YH, Park DW: Bilateral vidian nerve schwannomas associated with facial palsy. Case report and review of the literature. J Neurosurg; 2006 May;104(5):835-9
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  • [Title] Bilateral vidian nerve schwannomas associated with facial palsy. Case report and review of the literature.
  • Intracranial schwannomas are relatively common benign tumors arising from Schwann cells.
  • Among the cranial nerves, the vestibular division of the vestibulocochlear nerve is the site most commonly affected by these lesions, followed by the trigeminal nerve.
  • [MeSH-major] Bell Palsy / etiology. Brain Neoplasms / surgery. Cranial Nerve Neoplasms / surgery. Facial Nerve Diseases / surgery. Neoplasms, Multiple Primary / surgery. Neurilemmoma / surgery
  • [MeSH-minor] Adolescent. Facial Nerve / pathology. Facial Nerve / surgery. Female. Humans. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Neoplasm, Residual / diagnosis. Postoperative Complications / diagnosis. Sphenoid Bone / surgery. Tomography, X-Ray Computed

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  • [CommentIn] J Neurosurg. 2007 Jan;106(1):202; author reply 202-3 [17236512.001]
  • (PMID = 16703893.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Krampulz T, Hans VH, Oppel F, Dietrich U, Puchner MJ: Long-term relapse-free survival with supratentorial primitive neuroectodermal tumor in an adult: a case report. J Neurooncol; 2006 May;77(3):291-4
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  • OBJECTIVE: In adults, supratentorial primitive neuroectodermal tumor (sPNET) is a very rare undifferentiated embryoblastic neoplasm.
  • CONCLUSIONS: Although the prognosis of sPNET is reported to be poor, a small fraction with a rather benign biological and clinical behavior exists.
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Diagnosis, Differential. Disease-Free Survival. Humans. Ki-67 Antigen / metabolism. Male. Receptor, Nerve Growth Factor / metabolism. Treatment Outcome

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  • (PMID = 16528456.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Receptor, Nerve Growth Factor
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17. Messerli SM, Prabhakar S, Tang Y, Mahmood U, Giovannini M, Weissleder R, Bronson R, Martuza R, Rabkin S, Breakefield XO: Treatment of schwannomas with an oncolytic recombinant herpes simplex virus in murine models of neurofibromatosis type 2. Hum Gene Ther; 2006 Jan;17(1):20-30
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  • These studies demonstrate the ability of an oncolytic recombinant HSV vector to reduce the volume of schwannoma tumors in NF2 tumor models in mice and extend the possible therapeutic applications of oncolytic vectors for benign tumors to reduce mass while minimizing nerve damage.
  • [MeSH-minor] Animals. DNA, Recombinant / genetics. Disease Models, Animal. Genetic Vectors / genetics. Genetic Vectors / physiology. Genetic Vectors / toxicity. Humans. Magnetic Resonance Imaging / methods. Male. Mice. Mice, Nude. Mice, Transgenic. Neoplasm Transplantation

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  • [ErratumIn] Hum Gene Ther. 2006 Jul;17(7):796. Giovannini, Marco [added]
  • (PMID = 16409122.001).
  • [ISSN] 1043-0342
  • [Journal-full-title] Human gene therapy
  • [ISO-abbreviation] Hum. Gene Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Recombinant
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18. Hornick JL, Fletcher CD: Cellular neurothekeoma: detailed characterization in a series of 133 cases. Am J Surg Pathol; 2007 Mar;31(3):329-40
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  • Cellular neurothekeomas are distinctive benign cutaneous tumors of uncertain histogenesis.
  • In 30% of cases, neurothekeoma was suggested by the referring pathologist; the most common other diagnoses offered were plexiform fibrohistiocytic tumor, benign fibrous histiocytoma, and a low-grade sarcoma.
  • There is no good evidence that these lesions show nerve sheath differentiation and the nomenclature will likely change when the tumor cell lineage is better defined.
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Child. Child, Preschool. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Immunohistochemistry. Infant. Male. Middle Aged. Mitosis. Neoplasm Recurrence, Local. Sarcoma / diagnosis

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  • (PMID = 17325474.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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19. Nazir SA, Raza SA, Nazir S, Sherwood W, Bowker C, Lakhoo K: Challenges in the prenatal and post-natal diagnosis of mediastinal cystic hygroma: a case report. J Med Case Rep; 2008;2:256
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  • INTRODUCTION: Cystic hygroma is a benign congenital neoplasm that mostly presents as a soft-tissue mass in the posterior triangle of the neck.
  • At operation, the lesion was compressed by the left lung and was found to be close to the left phrenic nerve, which was carefully identified and preserved.
  • The phrenic nerve is not identifiable on prenatal ultrasound imaging, and it is therefore understandable that a mass close to the diaphragm may be mistaken for a congenital diaphragmatic hernia because of the location, morphology and potential phrenic nerve compression.

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  • (PMID = 18673546.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2518156
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20. Bień E, Stachowicz-Stencel T, Polczyńska K, Sierota D, Stefanowicz J, Szołkiewicz A, Drozyńska E, Birkholtz D, Izycka-Swieszewska E, Czauderna P, Kosiak W, Dubaniewicz M, Reiter M, Balcerska A: [Therapeutic difficulties in soft tissue sarcoma occurring in children with neurofibromatosis type 1 - own observations]. Med Wieku Rozwoj; 2008 Jan-Mar;12(1):477-84
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  • Neurofibromatosis type I (NF1) is one of the most common genetic disorders in man, predisposing to benign and malignant tumours.
  • Neurogenic tumours were diagnosed in three children (malignant peripheral nerve-sheath tumour in two and malignant triton tumour in one), while soft tissue sarcomas of rhabdomyosarcoma origin were found in two patients.
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Child, Preschool. Female. Humans. Infant. Male. Neoplasm Staging. Prognosis. Treatment Outcome


21. Lin D, Kashani-Sabet M, McCalmont T, Singer MI: Neurotropic melanoma invading the inferior alveolar nerve. J Am Acad Dermatol; 2005 Aug;53(2 Suppl 1):S120-2
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  • [Title] Neurotropic melanoma invading the inferior alveolar nerve.
  • BACKGROUND: Desmoplastic neurotropic melanoma (DNM) and neurotropic melanoma (NM), rare lesions of the head and neck, often present as a benign-appearing nodule which later progresses to cranial nerve involvement.
  • [MeSH-major] Cranial Nerve Neoplasms / secondary. Lip Neoplasms / pathology. Mandibular Nerve. Melanoma / pathology. Neoplasm Recurrence, Local. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Male. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 16021159.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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22. Michal M, Fanburg-Smith JC, Lasota J, Fetsch JF, Lichy J, Miettinen M: Minute synovial sarcomas of the hands and feet: a clinicopathologic study of 21 tumors less than 1 cm. Am J Surg Pathol; 2006 Jun;30(6):721-6
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  • Clinically, all tumors were thought to be benign processes such as a ganglion cyst or glomus tumor, and on microscopic examination, they were also often initially misinterpreted as benign lesions such as nerve sheath or (myo) fibroblastic tumors.
  • [MeSH-minor] Adult. Child. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Oncogene Proteins, Fusion. Polymerase Chain Reaction. Prognosis

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  • (PMID = 16723849.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Oncogene Proteins, Fusion; 0 / SYT-SSX fusion protein
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23. Bradshaw JW, Jansen JC: Management of vagal paraganglioma: is operative resection really the best option? Surgery; 2005 Feb;137(2):225-8
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  • BACKGROUND: Vagal paragangliomas cannot be resected without sacrifice of the vagal nerve.
  • The risk of bilateral vocal cord palsy has been reason to postpone treatment of this benign and slow growing neoplasm in hereditary cases.
  • The 10 patients that underwent an operation lost the vagal nerve; 60% of them had additional cranial nerve palsy postoperatively.
  • In the group of patients who were followed for an average period of 8.5 years, 3 patients (8%) developed cranial nerve palsy.
  • CONCLUSIONS: Aggressive treatment of vagal paragangliomas leads to unnecessary early loss of vagal nerve function.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Paraganglioma / surgery. Vagus Nerve Diseases / surgery
  • [MeSH-minor] Adult. Aged. Cranial Nerve Diseases / etiology. Female. Humans. Male. Middle Aged. Neoplasms, Multiple Primary / genetics. Neoplasms, Multiple Primary / physiopathology. Neoplasms, Multiple Primary / surgery. Postoperative Complications / etiology. Risk Factors. Vagus Nerve / physiopathology

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  • (PMID = 15674205.001).
  • [ISSN] 0039-6060
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Fei Z, Zhang X, Jiang XF, Liu WP, Wang XL, Xie L: Removal of large benign cephalonasal tumours by transbasal surgery combined with endonasal endoscopic sinus surgery and neuronavigation. J Craniomaxillofac Surg; 2007 Jan;35(1):30-4
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  • [Title] Removal of large benign cephalonasal tumours by transbasal surgery combined with endonasal endoscopic sinus surgery and neuronavigation.
  • The long-term postoperative sequelae included hypoosmia, ophthalmoplegia, paralysis of the 6th cranial nerve or hypopsia in 8 patients.
  • CONCLUSION: Transbasal surgery combined with endonasal endoscopic sinus surgery and neuronavigation is a particularly useful technique for resecting large benign cephalonasal tumours.
  • [MeSH-minor] Abducens Nerve Diseases / etiology. Adolescent. Adult. Child. Child, Preschool. Deglutition Disorders / etiology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Nasal Cavity / surgery. Neoplasm Recurrence, Local / surgery. Neoplasm, Residual / pathology. Nose Neoplasms / surgery. Olfaction Disorders / etiology. Ophthalmoplegia / etiology. Paralysis / etiology. Paranasal Sinus Neoplasms / surgery. Radiotherapy, Adjuvant. Reoperation. Retrospective Studies. Skull Base Neoplasms / surgery

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  • (PMID = 17261369.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
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25. Zou C, Smith KD, Liu J, Lahat G, Myers S, Wang WL, Zhang W, McCutcheon IE, Slopis JM, Lazar AJ, Pollock RE, Lev D: Clinical, pathological, and molecular variables predictive of malignant peripheral nerve sheath tumor outcome. Ann Surg; 2009 Jun;249(6):1014-22
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  • [Title] Clinical, pathological, and molecular variables predictive of malignant peripheral nerve sheath tumor outcome.
  • OBJECTIVE: Improved staging systems for malignant peripheral nerve sheath tumor (MPNST) prognostication and management are needed.
  • Ki67, vascular endothelial growth factor, p53, and pMEK were over-expressed in MPNST compared with benign neurofibromas.
  • [MeSH-major] Neoplasm Recurrence, Local / epidemiology. Nerve Sheath Neoplasms / metabolism. Nerve Sheath Neoplasms / pathology

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  • (PMID = 19474676.001).
  • [ISSN] 1528-1140
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers
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26. Campanati A, Brandozzi G, Sisti S, Bernardini ML, Offidani AM: Atypical neurothekeoma: a new case and review of the literature. J Cutan Pathol; 2007 May;34(5):435-7
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  • BACKGROUND: Neurothekeoma is a rare neoplasm ascribed into the broad category of benign peripheral nerve sheath tumors.
  • The atypical cellular variant of this neoplasm, showing a peculiar histological pattern, has been very rarely reported in literature.
  • RESULTS: The described neoplasm showed the histological features of atypical variant of cellular neurothekeoma with high-rate mitotic activity and deep penetration into subcutaneous fat.
  • CONCLUSIONS: Because only few cases of atypical neurothekeoma have been reported in literature, clinical and morphological available data on this neoplasm are very few, and its prognosis remains uncertain; anyway, dermatologists should be aware of histological features of this neoplasm for which a complete surgical excision is recommended.

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  • (PMID = 17448203.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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27. Diensthuber M, Lenarz T, Stöver T: [Neurotrophic factor expression in vestibular schwannoma. An overview]. Laryngorhinootologie; 2006 Oct;85(10):731-7
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  • The vestibular schwannoma is a benign, slow-growing neoplasm that originates from the neurolemmal sheath of the vestibular branch of the VIIIth cranial nerve.
  • Moreover, expression of numerous different neurotrophic factors has been shown in studies of nerve growth factor (NGF), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), fibroblast growth factor (FGF), neuregulin (NRG) and erythropoietin (EPO) indicating a biological role in development, maintainance or growth of vestibular schwannoma.
  • [MeSH-major] Nerve Growth Factors / metabolism. Neuroma, Acoustic / metabolism. Neuroma, Acoustic / pathology

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  • (PMID = 16612755.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Glial Cell Line-Derived Neurotrophic Factor; 0 / Nerve Growth Factors; 0 / Vascular Endothelial Growth Factor A; 62031-54-3 / Fibroblast Growth Factors; 62229-50-9 / Epidermal Growth Factor; 76057-06-2 / Transforming Growth Factors
  • [Number-of-references] 78
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28. Park JK, Ryu JK, Lee KH, Lee JK, Yoon WJ, Lee SH, Yoo JW, Woo SM, Lee GY, Lee CH, Kim YT, Yoon YB: Quantitative analysis of NPTX2 hypermethylation is a promising molecular diagnostic marker for pancreatic cancer. Pancreas; 2007 Oct;35(3):e9-15
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  • METHODS: We enrolled pathologically proven 33 pancreatic cancer patients and 22 benign pancreaticobiliary disease patients.
  • RESULTS: Pancreatic cancer cytology samples had statistically significant higher levels of NPTX2 methylation compared with benign diseases, and the optimal cutoff value of NPTX2 methylation was 1.2%.
  • [MeSH-major] Biomarkers, Tumor / analysis. C-Reactive Protein / genetics. Carcinoma, Pancreatic Ductal / diagnosis. CpG Islands. DNA Methylation. DNA, Neoplasm / analysis. Neoplasm Proteins / genetics. Nerve Tissue Proteins / genetics. Pancreatic Neoplasms / diagnosis. Polymerase Chain Reaction / methods

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  • (PMID = 17895837.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Neoplasm Proteins; 0 / Nerve Tissue Proteins; 0 / neuronal pentraxin; 9007-41-4 / C-Reactive Protein
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29. Shelekhova K, Kazakov DV, Michal M: Infiltrating retiform perineurioma: a case report. Ann Diagn Pathol; 2005 Oct;9(5):293-4
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  • Retiform perineurioma is a rare distinct histologic subtype of benign soft tissue perineurioma.
  • The patient was a 34-year-old woman with a neoplasm located between the deltoid muscle and the biceps.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16198959.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Vaiman M, Nagibin A, Hagag P, Buyankin A, Olevson J, Shlamkovich N: Subtotal and near total versus total thyroidectomy for the management of multinodular goiter. World J Surg; 2008 Jul;32(7):1546-51
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  • Follow-up checked injury of laryngeal nerves, hypoparathyroidism, hypothyroidism, pathology recurrence, and appearance of neoplasm.
  • Permanent recurrent laryngeal nerve (RLN) injury was observed in 1.4% in the TT group, 1.2% in the ST group, and 1.1% in the NT group (p > 0.1).
  • Recurrence of benign disease was noted in 491 patients (20.5% of ST and NT cases combined; p < 0.05), n = 482 (21.5%) after ST and n = 9 (5.9%) after NT.

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  • (PMID = 18340482.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] United States
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31. Liu X, Ma YQ, Wang J: [Prepubertal-type vulva fibroma: a clinicopathological study of two cases]. Zhonghua Bing Li Xue Za Zhi; 2010 Jan;39(1):40-3
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  • The tumor cells extended downward under the epithelium and infiltrated between the fat tissue, nerve fibers as well as the capillaries making a lesion looked somewhat like a harmatoma.
  • CONCLUSIONS: PVF is a benign mesenchymal lesion with a predilection of involving the vulva of prepubertal girls or adults in rare cases.
  • [MeSH-minor] Antigens, CD34 / metabolism. Child. Diagnosis, Differential. Female. Humans. Middle Aged. Myxoma / pathology. Neoplasm Recurrence, Local. Vulva / pathology. Vulva / surgery

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  • (PMID = 20388398.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Vimentin
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32. Summa A, Cerasti D, Crisi G, Ormitti F, Ventura E, Sabato M: Desmoplastic Fibroma of the Mandible: Usefulness of CT and MR Imaging in Diagnosis and Treatment. A Case Report. Neuroradiol J; 2010 Mar;23(1):109-13
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  • Desmoplastic fibroma (DF) is a rare non-metastasizing benign neoplasm of the bone characterized by aggressive local infiltration, also known as desmoid tumour.
  • In particular it can occur adjacent to and display contiguous extension along the mandibular nerve.

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  • (PMID = 24148342.001).
  • [ISSN] 1971-4009
  • [Journal-full-title] The neuroradiology journal
  • [ISO-abbreviation] Neuroradiol J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Dawamneh MF, Amra NK, Amr SS: Low grade fibromyxoid sarcoma: report of a case with fine needle aspiration cytology and histologic correlation. Acta Cytol; 2006 Mar-Apr;50(2):208-12
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  • BACKGROUND: Low grade fibromyxoid sarcoma has been fully described histologically; however, the fine needle aspiration (FNA) cytologic findings are scantily defined, and the distinction from other benign and malignant soft tissue tumors can be difficult.
  • CONCLUSION: Although low grade fibromyxoid sarcoma is a rare neoplasm, it should be recognized and distinguished from other soft tissue tumors because of its low malignant potential.
  • All spindle cell tumors with myxoid changes, such as myxoid liposarcoma, myxofibrosarcoma, cellular myxoma, myxoid leiomyosarcoma and peripheral nerve sheath tumors, should be considered in the differential diagnosis.

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  • (PMID = 16610692.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Miranpuri S, Snook E, Vang D, Yong RM, Chagares WE: Neurilemoma of the posterior tibial nerve and tarsal tunnel syndrome. J Am Podiatr Med Assoc; 2007 Mar-Apr;97(2):148-50
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  • [Title] Neurilemoma of the posterior tibial nerve and tarsal tunnel syndrome.
  • Tarsal tunnel syndrome is defined as a compressive neuropathy of the posterior tibial nerve in the tarsal canal.
  • A neurilemoma is an uncommon, benign, encapsulated neoplasm derived from Schwann cells.
  • [MeSH-major] Neurilemmoma / complications. Soft Tissue Neoplasms / complications. Tarsal Tunnel Syndrome / etiology. Tibial Nerve

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  • (PMID = 17369322.001).
  • [ISSN] 8750-7315
  • [Journal-full-title] Journal of the American Podiatric Medical Association
  • [ISO-abbreviation] J Am Podiatr Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Bekler H, Gokce A, Beyzadeoglu T: Chondroid syringoma of the hand: a rare localization. Handchir Mikrochir Plast Chir; 2007 Dec;39(6):430-2
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  • Chondroid syringoma is a rare benign neoplasm of the sweat glands that usually occurs in the head and neck region.
  • We describe a 18-year-old male patient with a benign chondroid syringoma that occurred at an unusual site, leading to compression symptoms of the ulnar nerve causing symptoms at the hypothenar region of the right hand.
  • [MeSH-minor] Adolescent. Biopsy. Humans. Image Enhancement. Magnetic Resonance Imaging. Male. Muscle, Skeletal / pathology. Neoplasm Invasiveness

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  • (PMID = 18058676.001).
  • [ISSN] 0722-1819
  • [Journal-full-title] Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der Peripheren Nerven und Gefässe : Organ der Vereinigung der Deutschen Plastischen Chirurgen
  • [ISO-abbreviation] Handchir Mikrochir Plast Chir
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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36. Goldsmith B, McDermott MW: Meningioma. Neurosurg Clin N Am; 2006 Apr;17(2):111-20, vi
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  • Total excision is an appropriate treatment option for patients with benign meningiomas that are resectable with minimal morbidity.
  • Fractionated conformal radiotherapy is an appropriate primary treatment option for patients with benign meningiomas of all sizes and all sites.
  • It is particularly appropriate and preferred for optic nerve sheath meningiomas, for which there are few alternatives.
  • [MeSH-minor] Dose Fractionation. Humans. Magnetic Resonance Imaging. Neoplasm Staging. Neurosurgical Procedures / methods. Radiosurgery / instrumentation. Survival Rate

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  • (PMID = 16793503.001).
  • [ISSN] 1042-3680
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 56
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37. Prayson RA, Yoder BJ, Barnett GH: Epidermal growth factor receptor is not amplified in schwannomas. Ann Diagn Pathol; 2007 Oct;11(5):326-9
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  • Both neurofibromas and schwannomas are capable of progression to malignant peripheral nerve sheath tumors (MPNSTs).
  • The mitogenic signaling for schwannomas is unlikely to be related to overexpression or amplification of EGFR; however, acquiring this signaling pathway might contribute to the progression of a subset of benign peripheral nerve sheath tumors to MPNST.
  • [MeSH-major] Nerve Sheath Neoplasms / metabolism. Neurilemmoma / metabolism. Receptor, Epidermal Growth Factor / metabolism
  • [MeSH-minor] Adult. Aged. DNA, Neoplasm / genetics. Disease Progression. Female. Gene Amplification. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Male. Middle Aged

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  • (PMID = 17870017.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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38. Huszar M, Moldenhauer G, Gschwend V, Ben-Arie A, Altevogt P, Fogel M: Expression profile analysis in multiple human tumors identifies L1 (CD171) as a molecular marker for differential diagnosis and targeted therapy. Hum Pathol; 2006 Aug;37(8):1000-8
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  • Here we carried out an immunohistochemical survey of L1 expression in normal adults and in a broad range of benign and malignant tumors using monoclonal antibody L1-11A and the novel monoclonal antibody L1-14.10.
  • In normal tissues, L1 was expressed in the collecting tubules of adult tissues and pediatric kidney and in peripheral nerve bundles.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Biomarkers, Tumor / metabolism. Genital Neoplasms, Female / metabolism. Isoantigens / metabolism. Membrane Glycoproteins / metabolism. Receptors, Cell Surface / metabolism

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  • (PMID = 16867862.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / CD177 protein, human; 0 / GPI-Linked Proteins; 0 / Isoantigens; 0 / Membrane Glycoproteins; 0 / Receptors, Cell Surface
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39. Alderete J, Novais EN, Dozois EJ, Rose PS, Sim FF: Morbidity and functional status of patients with pelvic neurogenic tumors after wide excision. Clin Orthop Relat Res; 2010 Nov;468(11):2948-53
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  • Patients with benign tumors had a mean MSTS score of 94%, while survivors of malignant disease had a mean of 57%.
  • CONCLUSION: Using a team approach, surgical excision provided high functional scores for patients with benign disease with a low rate of complications.
  • [MeSH-major] Bone Neoplasms / surgery. Neoplasms, Nerve Tissue / surgery. Orthopedic Procedures. Pelvic Bones / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Infant. Kaplan-Meier Estimate. Male. Middle Aged. Minnesota. Neoplasm Recurrence, Local. Recovery of Function. Retrospective Studies. Survival Rate. Time Factors. Treatment Outcome. Young Adult

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  • (PMID = 20668971.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2947704
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40. Mohammed F, Asaria J, Payne RJ, Freeman JL: Retrospective review of 242 consecutive patients treated surgically for parotid gland tumours. J Otolaryngol Head Neck Surg; 2008 Jun;37(3):340-6
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  • Of these patients, 183 (75.6%) had benign neoplasms, 51 (21.1%) had malignant neoplasms, and 8 (3.3%) had inflammatory or lymphatic lesions.
  • Common postoperative complications included temporary facial nerve palsy (23.6%), Frey syndrome (12.4%), and salivary fistula (5.0%).
  • The presenting symptoms of facial nerve weakness and lymphadenopathy were found to be strong indicators of malignant disease.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Diagnosis, Differential. Facial Pain / diagnosis. Facial Pain / epidemiology. Facial Pain / etiology. Female. Humans. Male. Middle Aged. Morbidity / trends. Neoplasm Staging. Ontario / epidemiology. Prognosis. Retrospective Studies. Risk Factors. Survival Rate / trends. Young Adult

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  • (PMID = 19128637.001).
  • [ISSN] 1916-0216
  • [Journal-full-title] Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
  • [ISO-abbreviation] J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Canada
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41. Kozakiewicz J, Włoczyk ES, Wolańska-Karut J: [A rare case of schwannoma in the parotid gland]. Otolaryngol Pol; 2005;59(3):449-51
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  • The authors described that rare benign neoplasm of peripheral nerve sheath, localized in parotid gland in a 68-year-old female.

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  • (PMID = 16117408.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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42. Erkan AN, Yavuz H, Ozer C, Ozer F, Ozluoglu L: Quality of life after surgery for benign disease of the parotid gland. J Laryngol Otol; 2008 Apr;122(4):397-402
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  • [Title] Quality of life after surgery for benign disease of the parotid gland.
  • OBJECTIVE: To evaluate quality of life after surgery for benign neoplastic disease of the parotid gland.
  • PATIENTS AND METHODS: A quality of life questionnaire, which was created from the Hebrew version of the University of Washington Quality of Life prototype, was applied to 55 patients who underwent surgery for benign neoplastic parotid disease.
  • Facial nerve impairment was reported by seven patients (13 per cent) during the early post-operative period; these patients recovered from that impairment.
  • CONCLUSION: The general status of patients who have undergone surgery for a benign parotid neoplasm can be assessed with a quality of life questionnaire.

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  • (PMID = 17537273.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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43. Lorenzoni PJ, Lange MC, Kay CS, Silvado CE, Scola RH, Werneck LC: [Fibrolipomatous hamartoma of the median nerve: case report]. Arq Neuropsiquiatr; 2005 Sep;63(3B):881-4
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  • [Title] [Fibrolipomatous hamartoma of the median nerve: case report].
  • Fibrolipomatous hamartoma is a rare benign neoplasm that in some cases is associated with macrodactylia.
  • Investigation with X-ray, ultrasonography, electrodiagnosis, magnetic resonance image of the left wrist and hand showed carpal tunnel syndrome with macrodactylia by fibrolipomatous hamartoma of the median nerve.
  • [MeSH-major] Carpal Tunnel Syndrome / etiology. Hamartoma / complications. Median Nerve / pathology. Median Neuropathy / pathology

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  • (PMID = 16258677.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Brazil
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44. Nazarian Y, Talmi YP, Wolf M, Horowitz Z, Bedrin L, Pfeffer R, Kronenberg J: [Recurrent pleomorphic adenomas of the parotid gland--treatment and outcome]. Harefuah; 2007 Feb;146(2):82-4, 168
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  • Epithelial tumors of the parotid gland comprise 3% of head and neck tumors, and 70%-80% of those are benign.
  • Treatment of RPAs is challenging due to a high risk of facial nerve paresis (7%-50%) and of re-recurrence.
  • Two patients (10%) had permanent paresis of a single branch of the facial nerve.
  • [MeSH-major] Adenoma / pathology. Neoplasm Recurrence, Local / pathology. Parotid Neoplasms / pathology

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  • (PMID = 17352271.001).
  • [ISSN] 0017-7768
  • [Journal-full-title] Harefuah
  • [ISO-abbreviation] Harefuah
  • [Language] heb
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Israel
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45. Suárez-Fente V, Llorente-Pendás JL, Gómez-Martínez J, García-González LA, López-Alvarez F, Suárez-Nieto C: [Primary tumours of the parapharyngeal space. Our experience in 51 patients]. Acta Otorrinolaringol Esp; 2009 Jan-Feb;60(1):19-24
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  • RESULTS: Seventy percent of the parapharyngeal space neoplasms were benign and thirty percent malignant.
  • Pleomorphic adenoma was the most common neoplasm (37 %), followed by miscellaneous benign tumours (34 %), paraganglioma (21 %), and neurogenic tumours (8 %).
  • The most common complications were those deriving from damage to nerve structures.

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  • (PMID = 19268125.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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46. Guo ZH, Huang H, DU T, Xu KW, Cao Y, Chen JQ, Dong W, Yao YS, Lin TX, Xie WL, Jiang C, Han JL, Huang J: [Inhibition and significance of pigment epithelium-derived factor in the development and metastasis of prostate cancer]. Zhonghua Yi Xue Za Zhi; 2010 Nov 16;90(42):2980-3
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  • METHODS: The expression of PEDF was examined in the normal prostate tissue, benign prostatic hyperplasia, prostate cancer tissue and prostate cancer cell lines, PC-3 and Lncap by immunohistochemical SP method and Western blot.
  • RESULTS: In normal prostate tissue and benign prostate tissue, the expression of PEDF were elevated and it was far higher than the prostate cancer and prostate cancer cell line.
  • [MeSH-major] Eye Proteins / metabolism. Nerve Growth Factors / metabolism. Prostatic Neoplasms / metabolism. Prostatic Neoplasms / pathology. Serpins / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Metastasis

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  • (PMID = 21211310.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Eye Proteins; 0 / Nerve Growth Factors; 0 / Serpins; 0 / pigment epithelium-derived factor
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47. Yaşar H, Ozkul H, Verim A, Ilhan E, Kökten N, Dereci G: [An evaluation of parotid gland masses]. Kulak Burun Bogaz Ihtis Derg; 2007;17(2):70-4
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  • Histopathological diagnoses were benign in 33 patients (66%), malignant in nine patients (18%), and tumor-like pathologies in eight patients (16%), the most common being pleomorphic adenoma (n=28, 56%), Warthin's tumor (n=4, 8%), and squamous cell carcinoma (n=4, 8%).
  • If the deep lobe of the gland is involved, total parotidectomy should be performed with preservation of the facial nerve.
  • [MeSH-major] Neoplasm Recurrence, Local / epidemiology. Parotid Diseases / epidemiology

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  • (PMID = 17527056.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] tur
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Turkey
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48. Fyrmpas G, Konstantinidis I, Hatzibougias D, Vital V, Constantinidis J: Intraparotid facial nerve schwannoma: management options. Eur Arch Otorhinolaryngol; 2008 Jun;265(6):699-703
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  • [Title] Intraparotid facial nerve schwannoma: management options.
  • Intraparotid facial nerve schwannoma (FNS) is a very rare, benign tumour mimicking pleomorphic adenoma.
  • Resection of this slow growing tumour may result in unnecessary facial nerve paralysis.
  • The aim of this study is to present results of facial nerve schwannoma treatment at our institution and proposes a management plan.
  • Two patients had facial weakness and underwent superficial parotidectomy, resection of tumour and facial nerve repair with a free graft from the greater auricular nerve.
  • All tumours were confirmed histologically as facial nerve schwannomas.
  • Patients with resection of facial nerve schwannoma had a postoperative House Brackmann grade III and IV.
  • Patients with biopsy had normal postoperative facial nerve function and the tumour did not grow significantly.
  • There is no preoperative diagnostic modality that can identify facial nerve schwannoma with certainty.
  • Difficulty in locating the facial nerve intraoperatively raises suspicion of a neurogenous tumour of the facial nerve and this may prevent unnecessary damage to the nerve.
  • Not every facial nerve schwannoma should be resected.
  • This decision is based on (a) the extent of tumour (b) preoperative facial nerve function (c) best results achieved with nerve repair and (d) patient's preferences.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Facial Nerve / pathology. Neurilemmoma / surgery. Otorhinolaryngologic Surgical Procedures / methods. Parotid Region / pathology
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Retrospective Studies. Surgical Flaps. Tomography, X-Ray Computed. Treatment Outcome. Ultrasonography

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  • (PMID = 17992534.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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49. Altamirano-Ley J, Estrada-Sánchez GR, Ochoa-Carrillo FJ: [Positron emission tomography and computed tomography (PET/CT) in lung cancer]. Cir Cir; 2007 Jul-Aug;75(4):303-11
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  • BACKGROUND: Lung cancer is the most frequent cause of death due to neoplasm in Western populations, with >660,000 new diagnoses of lung cancer per year according to the World Health Organization.
  • One relatively common cause of false positives is the vocal cord and adjacent muscles contralateral and compensatory to the lung lesion that show an increased uptake of (18)FDG because of lesions in the laryngeal nerve by the tumor or secondary to surgery.
  • This can resolve doubts by the oncologist and patient when there is a suspicious malignant lesion by the following: characterizing solitary pulmonary nodules (benign or malignant), localizing the optimal site for the biopsy, diagnosis of the primary tumor for initial staging, evaluation of mediastinal involvement and distant metastasis, evaluate and restage residual tumor, assessment of recurrence, monitoring response, prognostic prediction and radiotherapy planning.
  • [MeSH-minor] Diagnosis, Differential. Humans. Neoplasm Metastasis. Neoplasm Staging. Solitary Pulmonary Nodule / diagnosis

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  • (PMID = 18053364.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Mexico
  • [Number-of-references] 50
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50. Boujaoude J: Role of endoscopic ultrasound in diagnosis and therapy of pancreatic adenocarcinoma. World J Gastroenterol; 2007 Jul 21;13(27):3662-6
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  • Endoscopic ultrasound cannot accurately distinguish benign from malignant changes in the primary lesion or lymph node on imaging alone.
  • [MeSH-minor] Antineoplastic Agents / administration & dosage. Autonomic Nerve Block / methods. Biopsy, Fine-Needle / methods. Catheter Ablation / methods. Celiac Plexus. Cholangiography / methods. Diagnosis, Differential. Drug Delivery Systems / methods. Humans. Neoplasm Staging / methods. Photochemotherapy / methods. Predictive Value of Tests. Sensitivity and Specificity

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  • (PMID = 17659723.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Editorial; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 50
  • [Other-IDs] NLM/ PMC4250635
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51. Socolovsky M, Spaho N, Cueto DG, Doglietto F, Fernandez E: Reactive lymphoid follicular hyperplasia mimicking a peripheral nerve tumor. Surg Neurol; 2008 Nov;70(5):514-7
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  • [Title] Reactive lymphoid follicular hyperplasia mimicking a peripheral nerve tumor.
  • BACKGROUND: Reactive lymphoid follicular hyperplasia is a benign proliferation of lymphoid follicles, which can develop wherever lymphoid tissue is present.
  • We present the unique case of an RLFH that involved the radial nerve and presented as a peripheral nerve tumor.
  • Magnetic resonance findings revealed a contrast-enhancing, spindle-shaped tumor, suggestive of a schwannoma or neurofibroma, along the course of the radial nerve.
  • The intraoperative appearance was that of an infiltrating tissue around a lateral branch of the nerve, which could be resected en bloc.
  • Pathologic examination documented hyperplastic lymphoid tissue surrounding the nerve, and immunostaining confirmed the diagnosis of benign reactive follicular hyperplasia.
  • CONCLUSION: To our knowledge this is the first description of RLFH affecting a peripheral nerve and mimicking a neoplasm.
  • This rare and benign condition should be considered in the differential diagnosis of peripheral nerve tumors.

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  • (PMID = 18261777.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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52. Keijser S, Missotten GS, Bonfrer JM, de Wolff-Rouendaal D, Jager MJ, de Keizer RJ: Immunophenotypic markers to differentiate between benign and malignant melanocytic lesions. Br J Ophthalmol; 2006 Feb;90(2):213-7
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  • [Title] Immunophenotypic markers to differentiate between benign and malignant melanocytic lesions.
  • [MeSH-major] Antigens, Neoplasm / analysis. Conjunctival Diseases / diagnosis. S100 Proteins / analysis
  • [MeSH-minor] Biomarkers / analysis. Carcinoembryonic Antigen / analysis. Cell Cycle Proteins / analysis. Conjunctival Neoplasms / diagnosis. Conjunctival Neoplasms / immunology. Diagnosis, Differential. Humans. Immunohistochemistry / methods. MART-1 Antigen. Melanoma / diagnosis. Melanoma / immunology. Melanosis / diagnosis. Melanosis / immunology. Neoplasm Proteins / analysis. Nerve Growth Factors / analysis. Nevus / diagnosis. Nevus / immunology. S100 Calcium Binding Protein beta Subunit. Uveal Neoplasms / diagnosis. Uveal Neoplasms / immunology

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  • (PMID = 16424536.001).
  • [ISSN] 0007-1161
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers; 0 / Carcinoembryonic Antigen; 0 / Cell Cycle Proteins; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Neoplasm Proteins; 0 / Nerve Growth Factors; 0 / S100 Calcium Binding Protein beta Subunit; 0 / S100 Proteins; 0 / S100A1 protein; 0 / S100B protein, human; 105504-00-5 / S100A6 protein, human
  • [Other-IDs] NLM/ PMC1860182
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53. Zhi K, Ren W, Zhou H, Wen Y, Zhang Y: Management of parapharyngeal-space tumors. J Oral Maxillofac Surg; 2009 Jun;67(6):1239-44
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  • The most common class of lesion was salivary-gland neoplasm, accounting for 74 cases (45.68%).
  • The most common approach was transcervical-transparotid for benign tumors.
  • [MeSH-minor] Adenoma, Pleomorphic / surgery. Adult. Biopsy, Fine-Needle. Carcinoma / secondary. Carcinoma / surgery. Chemotherapy, Adjuvant. Cranial Nerve Diseases / etiology. Female. Follow-Up Studies. Humans. Magnetic Resonance Angiography. Magnetic Resonance Imaging. Male. Neck Muscles / surgery. Neoplasm Recurrence, Local / pathology. Parotid Gland / surgery. Postoperative Complications. Radiotherapy, Adjuvant. Retrospective Studies. Salivary Gland Neoplasms / surgery. Tomography, X-Ray Computed

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  • [CommentIn] J Oral Maxillofac Surg. 2010 May;68(5):1209-11; author reply 1212 [20403530.001]
  • (PMID = 19446210.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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54. Lin TY, Zhang AY, Bayer-Garner IB, Krell JM, Acker SM: Epithelial sheath neuroma: a case report and discussion of the literature. Am J Dermatopathol; 2006 Jun;28(3):216-9
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  • ESN is characterized by enlarged nerve fibers ensheathed by a sometimes keratinized squamous epithelium located in the superficial dermis where large nerves are not normally found.
  • It is believed to be a benign neoplasm and simple excision is curative.

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  • (PMID = 16778489.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 16
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55. Kneitz H, Weyandt G, Meissner C, Gebhart E, Bröcker EB: Dermal schwannoma (neurilemmoma): a peculiar foreign body reaction? Am J Dermatopathol; 2010 Jun;32(4):367-9
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  • Schwannoma is usually a subcutaneous benign neoplasm that derives from nerve sheath.

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  • (PMID = 20216197.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9004-34-6 / Cellulose
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56. Coco DP, Hirsch MS, Hornick JL: Smoothelin is a specific marker for smooth muscle neoplasms of the gastrointestinal tract. Am J Surg Pathol; 2009 Dec;33(12):1795-801
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  • A total of 150 mesenchymal neoplasms of the GI tract, abdominal cavity, and retroperitoneum were retrieved from consult and surgical pathology archives, including 54 GISTs (8 KIT-negative; 13 desmin-positive), 17 GI leiomyosarcomas (LMS), 11 GI mural leiomyomas, 13 leiomyomas of the muscularis mucosae, 12 gastric schwannomas, 15 inflammatory myofibroblastic tumors, 9 cases of mesenteric desmoid fibromatosis, 10 dedifferentiated liposarcomas, and 9 malignant peripheral nerve sheath tumors.
  • Cytoplasmic expression of smoothelin was present in all 24 (100%) benign smooth muscle tumors (mural leiomyomas and leiomyomas of the muscularis mucosae).
  • None of the GISTs, desmoid tumors, inflammatory myofibroblastic tumors, schwannomas, dedifferentiated liposarcomas, or malignant peripheral nerve sheath tumors showed cytoplasmic reactivity for smoothelin.
  • In summary, diffuse cytoplasmic staining for smoothelin is highly sensitive and specific for benign leiomyomas of the GI tract.
  • These findings suggest that the extent and pattern of smoothelin expression may help differentiate between benign and malignant mesenchymal tumors of the GI tract, and may be useful in distinguishing leiomyomas from KIT-negative and/or desmin-positive GISTs.
  • [MeSH-minor] Cell Differentiation. Cell Nucleus / chemistry. Cytoplasm / chemistry. Desmin / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Neoplasm Staging. Predictive Value of Tests. Proto-Oncogene Proteins c-kit / analysis. Sensitivity and Specificity

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  • (PMID = 19950405.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cytoskeletal Proteins; 0 / Desmin; 0 / Muscle Proteins; 0 / SMTN protein, human; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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57. Fukaya R, Yoshida K, Ohira T, Kawase T: Trigeminal schwannomas: experience with 57 cases and a review of the literature. Neurosurg Rev; 2010 Apr;34(2):159-71
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  • Trigeminal schwannoma is a mostly benign tumor that can be cured by complete resection.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neurilemmoma / surgery. Trigeminal Nerve Diseases / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Cranial Fossa, Middle / surgery. Dura Mater / surgery. Female. Follow-Up Studies. Humans. Karnofsky Performance Status. Male. Middle Aged. Neoplasm Recurrence, Local. Neurosurgical Procedures / methods. Radiosurgery. Retrospective Studies. Skull Base / surgery. Temporal Bone / surgery. Treatment Outcome. Young Adult

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  • (PMID = 20963463.001).
  • [ISSN] 1437-2320
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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58. Miettinen M, Makhlouf HR, Sobin LH, Lasota J: Plexiform fibromyxoma: a distinctive benign gastric antral neoplasm not to be confused with a myxoid GIST. Am J Surg Pathol; 2009 Nov;33(11):1624-32
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  • [Title] Plexiform fibromyxoma: a distinctive benign gastric antral neoplasm not to be confused with a myxoid GIST.
  • Plexiform fibromyxoma is a distinctive benign gastric antral neoplasm that should be separated from GIST, nerve sheath tumors, and other fibromyxoid neoplasms.
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Child. Diagnosis, Differential. Disease-Free Survival. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Invasiveness. Young Adult

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  • (PMID = 19675452.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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59. Bakoyiannis KC, Georgopoulos SE, Klonaris CN, Tsekouras NS, Felekouras ES, Pikoulis EA, Griniatsos JE, Papalambros EL, Bastounis EA: Surgical treatment of carotid body tumors without embolization. Int Angiol; 2006 Mar;25(1):40-5
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  • AIM: Carotid body (CB) paragangliomas are rare neoplasms, usually benign.
  • Three patients had temporal cranial nerve lesions that resolved within 3 months.
  • [MeSH-minor] Adult. Aged. Angioplasty. Female. Humans. Male. Medical Records. Middle Aged. Neoplasm Staging. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 16520723.001).
  • [ISSN] 0392-9590
  • [Journal-full-title] International angiology : a journal of the International Union of Angiology
  • [ISO-abbreviation] Int Angiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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60. Kim NR, Suh YL, Shin HJ: Thoracic pediatric intramedullary schwannoma: report of a case. Pediatr Neurosurg; 2009;45(5):396-401
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  • Schwann cells are generally present in the nerve root, not in the spinal cord.
  • The ideal treatment for intramedullary schwannoma of histologically benign nature is surgical resection.
  • [MeSH-minor] Biopsy. Child. Diagnosis, Differential. Female. Humans. Neoplasm, Residual / pathology. Thoracic Vertebrae

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19940539.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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61. Chiang FY, Lin JC, Lee KW, Wang LF, Tsai KB, Wu CW, Lu SP, Kuo WR: Thyroid tumors with preoperative recurrent laryngeal nerve palsy: clinicopathologic features and treatment outcome. Surgery; 2006 Sep;140(3):413-7
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  • [Title] Thyroid tumors with preoperative recurrent laryngeal nerve palsy: clinicopathologic features and treatment outcome.
  • BACKGROUND: The aim of this present study is to define the significance of recurrent laryngeal nerve palsy (RLNP) detected before surgery for thyroid diseases with regard to the incidence of malignancy, histopathologic distribution, extrathyroidal invasion, management, and prognosis.
  • RESULTS: Of these 16 patients, 1 had benign thyroid disease, while the other 15 had malignancy (94%).
  • The recurrent laryngeal nerve could be dissected from the thyroid neoplasm in 3 patients, 2 of whom experienced recovery of this nerve's function postoperatively.

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  • (PMID = 16934603.001).
  • [ISSN] 0039-6060
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Amoli FA, Mehrabani PM, Tari AS: Aggressive orbital optic nerve meningioma with benign microscopic features: a case report. Orbit; 2007 Dec;26(4):271-4
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  • [Title] Aggressive orbital optic nerve meningioma with benign microscopic features: a case report.
  • Primary optic nerve meningiomas occur at lower ages than meningiomas arising from the coverings of the brain and spinal cord.
  • MRI images revealed a large left orbital mass with optic nerve involvement and extension to the left maxillary sinus, pterygoid fossa and the dura in the floor of the anterior fossa.
  • Microscopic study showed meningotheliomatous meningioma with extensive involvement of the optic nerve and invasion of the optic disc, sclera and choroid.
  • The interesting aspect of this case was the aggressive behavior of the tumor with intraocular invasion, despite its benign histopathological features, which led to wide exenteration of the eye together with resection of the upper and lower lids.
  • [MeSH-major] Meningioma / pathology. Optic Nerve Neoplasms / pathology
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neoplasm Recurrence, Local

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  • (PMID = 18097966.001).
  • [ISSN] 0167-6830
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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63. Krause K, Karger S, Sheu SY, Aigner T, Kursawe R, Gimm O, Schmid KW, Dralle H, Fuhrer D: Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis. J Endocrinol; 2008 Aug;198(2):291-9
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  • We have recently found an increased expression of amyloid precursor protein (APP) in cold thyroid nodules that are difficult to classify as a truly benign thyroid neoplasm or a lesion with the potential for further dedifferentiation.
  • In vivo analysis of APP expression and downstream signalling was performed in benign and malignant thyroid tissues.
  • [MeSH-minor] Adaptor Proteins, Signal Transducing / genetics. Animals. Blotting, Western. Cell Line. Cell Line, Tumor. Gene Expression / drug effects. Humans. Immunohistochemistry. In Vitro Techniques. Insulin / pharmacology. Microscopy, Confocal. Nerve Tissue Proteins / genetics. Nuclear Proteins / genetics. Polymerase Chain Reaction. Protein Transport / drug effects. Rats. Reverse Transcriptase Polymerase Chain Reaction. Shc Signaling Adaptor Proteins / genetics. Thyroid Gland / drug effects. Thyroid Gland / metabolism. Thyroid Gland / pathology. Thyrotropin / pharmacology

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  • (PMID = 18480379.001).
  • [ISSN] 1479-6805
  • [Journal-full-title] The Journal of endocrinology
  • [ISO-abbreviation] J. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / APBB1 protein, human; 0 / Adaptor Proteins, Signal Transducing; 0 / Amyloid beta-Protein Precursor; 0 / Insulin; 0 / MAPK8IP1 protein, human; 0 / Nerve Tissue Proteins; 0 / Nuclear Proteins; 0 / SHC1 protein, human; 0 / Shc Signaling Adaptor Proteins; 9002-71-5 / Thyrotropin
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64. Ito T, Tsutsumi T, Ohno K, Takizawa T, Kitamura K: Intracranial angiosarcoma arising from a schwannoma. J Laryngol Otol; 2007 Jan;121(1):68-71
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  • Angiosarcomas rarely arise from schwannomas, but we describe here a case of angiosarcoma that arose from a remnant of a benign vestibular schwannoma that had been removed 10 years earlier.
  • The histological diagnosis was confirmed by the immunohistochemical findings of positivity for CD34 antigen and S-100 protein in the resected tumour.A review of the literature revealed four other cases of angiosarcoma with schwannoma, all of which arose from an extracranial nerve.
  • [MeSH-minor] Aged. Brain Abscess / microbiology. Fatal Outcome. Humans. Male. Neoplasm Invasiveness. Staphylococcal Infections / microbiology

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  • (PMID = 16995966.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 11
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65. Mineva I, Gartner W, Hauser P, Kainz A, Löffler M, Wolf G, Oberbauer R, Weissel M, Wagner L: Differential expression of alphaB-crystallin and Hsp27-1 in anaplastic thyroid carcinomas because of tumor-specific alphaB-crystallin gene (CRYAB) silencing. Cell Stress Chaperones; 2005;10(3):171-84
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  • In this study, we investigated the molecular mechanisms that affect the expression of alphaB-crystallin in benign goiters (n = 7) and highly malignant anaplastic thyroid carcinomas (ATCs) (n = 3).
  • In contrast, considerable expression of Hsp27-1 in benign and malignant thyroid tissue was demonstrated.
  • Immunofluorescence analysis revealed no relevant topological differences between benign and malignant thyrocytes in the cytoplasmic staining of both proteins.
  • [MeSH-major] Carcinoma / genetics. Gene Expression Regulation, Neoplastic. Intermediate Filament Proteins / genetics. Nerve Tissue Proteins / genetics. Protein Kinases / genetics. Repressor Proteins / genetics. Thyroid Neoplasms / genetics. Transcription Factors / genetics
  • [MeSH-minor] Animals. COS Cells. Cell Line, Tumor. Cloning, Molecular. DNA, Complementary / biosynthesis. Down-Regulation. Gene Silencing. Genes, Reporter. Goiter. HSP27 Heat-Shock Proteins. Heat-Shock Proteins / analysis. Heat-Shock Proteins / metabolism. Humans. Luciferases / genetics. Neoplasm Proteins / analysis. Neoplasm Proteins / metabolism. Oligonucleotide Array Sequence Analysis. Promoter Regions, Genetic. RNA, Messenger / metabolism. Tissue Extracts / chemistry. Tissue Extracts / genetics. Tissue Extracts / metabolism. Transfection. alpha-Crystallin B Chain

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  • (PMID = 16184762.001).
  • [ISSN] 1355-8145
  • [Journal-full-title] Cell stress & chaperones
  • [ISO-abbreviation] Cell Stress Chaperones
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CRYAB protein, human; 0 / DNA, Complementary; 0 / HSP27 Heat-Shock Proteins; 0 / HSPB1 protein, human; 0 / Heat-Shock Proteins; 0 / Intermediate Filament Proteins; 0 / Neoplasm Proteins; 0 / Nerve Tissue Proteins; 0 / RNA, Messenger; 0 / Repressor Proteins; 0 / TFCP2L1 protein, human; 0 / Tissue Extracts; 0 / Transcription Factors; 0 / alpha-Crystallin B Chain; EC 1.13.12.- / Luciferases; EC 2.7.- / Protein Kinases
  • [Other-IDs] NLM/ PMC1226015
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66. Agnarsdóttir M, Sooman L, Bolander A, Strömberg S, Rexhepaj E, Bergqvist M, Ponten F, Gallagher W, Lennartsson J, Ekman S, Uhlen M, Hedstrand H: SOX10 expression in superficial spreading and nodular malignant melanomas. Melanoma Res; 2010 Dec;20(6):468-78
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  • SOX10 is a transcription factor expressed in nerve cells and melanocytes.
  • Expression patterns were determined in 106 primary tumors and 39 metastases in addition to 16 normal skin samples and six benign nevi employing immunohistochemistry and tissue microarrays.
  • SOX10 was strongly expressed in the benign tissues, but for the malignant tumors superficial spreading melanomas stained stronger than nodular malignant melanomas (P=0.008).
  • With the automated algorithm there was an inverse correlation between the SOX10 staining intensity and the proliferation marker, Ki-67 (ρ=-0.173, P=0.02) and a significant difference in the intensity signal between the benign tissues, the primary tumors and the metastases where the metastases stained the weakest (P≤0.001).
  • [MeSH-minor] Cell Growth Processes / physiology. Cell Line, Tumor. Cell Movement / physiology. Down-Regulation. Humans. Immunohistochemistry. Neoplasm Metastasis. RNA, Small Interfering / administration & dosage. RNA, Small Interfering / genetics. Transfection

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  • (PMID = 20890226.001).
  • [ISSN] 1473-5636
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Small Interfering; 0 / SOX10 protein, human; 0 / SOXE Transcription Factors
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67. Robinson S, Patel N, Wormald PJ: Endoscopic management of benign tumors extending into the infratemporal fossa: a two-surgeon transnasal approach. Laryngoscope; 2005 Oct;115(10):1818-22
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  • [Title] Endoscopic management of benign tumors extending into the infratemporal fossa: a two-surgeon transnasal approach.
  • OBJECTIVES/HYPOTHESIS: Preliminary results of the endoscopic two-surgeon technique for the management of benign infratemporal fossa tumors are presented.
  • METHODS: Four patients with juvenile nasopharyngeal angiofibroma, a patient with an inverting papilloma, and a patient with a maxillary nerve schwannoma were reviewed.
  • CONCLUSION: The two-surgeon transnasal technique allows benign infratemporal fossa tumors to be resected endoscopically.
  • [MeSH-minor] Adolescent. Adult. Child. Endoscopy. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neurilemmoma / pathology. Neurilemmoma / surgery. Papilloma, Inverted / pathology. Papilloma, Inverted / surgery

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  • (PMID = 16222202.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. Lee M, Kalani MY, Cheshier S, Gibbs IC, Adler JR, Chang SD: Radiation therapy and CyberKnife radiosurgery in the management of craniopharyngiomas. Neurosurg Focus; 2008;24(5):E4
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  • OBJECT: Many benign intracranial tumors are amenable to radiotherapy treatment including meningiomas, schwannomas, pituitary tumors, and craniopharyngiomas.
  • [MeSH-minor] Adolescent. Adult. Aged. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Optic Nerve Diseases / etiology. Remission Induction. Retrospective Studies. Salvage Therapy. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18447743.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 55
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69. Cohen SM, Burkey BB, Netterville JL: Surgical management of parapharyngeal space masses. Head Neck; 2005 Aug;27(8):669-75
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  • RESULTS: One hundred sixty-six PPS masses were identified: 21 (12.7%) were malignant, 145 (87.3%) were benign, 76 (45.8%) were vascular, and 69 (41.6 %) involved the skull base.
  • To identify the facial nerve, 20 transparotid-transcervical approaches (13.6%) were performed.
  • Expected neurologic sequelae resulted from cranial nerve involvement by tumor.
  • CONCLUSION: Careful patient assessment and surgical techniques allow the oncologically safe removal of benign, vascular, and skull base PPS tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Infant. Lymph Node Excision. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasms, Vascular Tissue / diagnosis. Neoplasms, Vascular Tissue / pathology. Neoplasms, Vascular Tissue / surgery. Paraganglioma / diagnosis. Paraganglioma / pathology. Paraganglioma / surgery. Retrospective Studies. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / pathology. Salivary Gland Neoplasms / surgery. Skull Base Neoplasms / diagnosis. Skull Base Neoplasms / pathology. Skull Base Neoplasms / surgery. Treatment Outcome

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  • [Copyright] Copyright 2005 Wiley Periodicals, Inc.
  • (PMID = 15880689.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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70. Brasileiro BF, Martins-Filho PR, Piva MR, da Silva LC, Nonaka CF, Miguel MC: Myofibroma of the oral cavity. A rare spindle cell neoplasm. Med Oral Patol Oral Cir Bucal; 2010 Jul;15(4):e596-600
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  • [Title] Myofibroma of the oral cavity. A rare spindle cell neoplasm.
  • Myofibroma is an uncommon spindle cell neoplasm rarely found in oral cavity.
  • Misdiagnosis included benign and malignant spindle cell lesions of nerve tissue or smooth muscle origin, such as neurofibroma, leiomyoma and sarcomas.

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  • (PMID = 20038894.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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71. Nah YW, Suh JH, Choi DH, Ko BK, Nam CW, Kim GY, Im YC, Cho HR: Benign retroperitoneal schwannoma: surgical consideration. Hepatogastroenterology; 2005 Nov-Dec;52(66):1681-4
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  • [Title] Benign retroperitoneal schwannoma: surgical consideration.
  • Schwannoma, which arises from the neural sheath of peripheral nerves, is the most common benign tumor in the retroperitoneum in adults.
  • During surgery, it seems to be unnecessary to identify the small peripheral nerve from which it develops.
  • [MeSH-minor] Adult. Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Korea. Laparoscopy / methods. Laparotomy / methods. Middle Aged. Neoplasm Staging. Retrospective Studies. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome. Ultrasonography, Doppler

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  • (PMID = 16334756.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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72. Gaeta M, Mazziotti S, Minutoli F, Genitori A, Toscano A, Rodolico C, Blandino A: MR imaging findings of focal myositis: a pseudotumour that may mimic muscle neoplasm. Skeletal Radiol; 2009 Jun;38(6):571-8
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  • [Title] MR imaging findings of focal myositis: a pseudotumour that may mimic muscle neoplasm.
  • Dynamic enhancement pattern corresponded to the type usually seen in benign soft tissue lesions.

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  • (PMID = 19255757.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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73. Johnson JT, Ferlito A, Fagan JJ, Bradley PJ, Rinaldo A: Role of limited parotidectomy in management of pleomorphic adenoma. J Laryngol Otol; 2007 Dec;121(12):1126-8
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  • There is continued controversy over the extent of parotidectomy required for removal of a benign pleomorphic adenoma from the parotid gland.
  • Currently, consensus exists that the integrity of the facial nerve must be preserved when the tumour is totally removed.
  • As a result of experience gained in the first half of the twentieth century, it was recommended that superficial parotidectomy with facial nerve dissection should be the minimal biopsy for pleomorphic adenoma.
  • Since that time, however, research has indicated that partial parotidectomy or extracapsular dissection of benign pleomorphic adenoma can be accomplished with preservation of the facial nerve without an increase in tumour recurrence.
  • [MeSH-minor] Dissection / methods. Facial Nerve / surgery. Humans. Neoplasm Recurrence, Local / prevention & control. Postoperative Complications / prevention & control. Sweating, Gustatory / prevention & control

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  • (PMID = 17666140.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 21
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74. Randolph GW, Kamani D: The importance of preoperative laryngoscopy in patients undergoing thyroidectomy: voice, vocal cord function, and the preoperative detection of invasive thyroid malignancy. Surgery; 2006 Mar;139(3):357-62
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  • METHODS: In a group of 365 consecutive patients undergoing thyroidectomy, the group of 21 patients with invasive thyroid malignancy was compared with the 344 patients who had benign thyroid disease or noninvasive cancers.
  • RESULTS: Preoperative recurrent laryngeal nerve paralysis was a robust marker for invasive thyroid malignancy, being present in 70% of patients with invasive disease and only 0.3% of patients with noninvasive disease.
  • Because of the prevalence (approximately 6% in our study) of invasive thyroid disease, the importance of preoperative diagnosis of invasive disease in operative planning and patient counseling, and the importance of vocal cord functional analysis in recurrent laryngeal nerve management algorithms for nerves found infiltrated at operation, and laryngoscopic examination is recommended for all patients undergoing thyroid operation.
  • [MeSH-minor] Aged. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Preoperative Care. Recurrence. Retrospective Studies. Tomography, X-Ray Computed. Voice

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  • [CommentIn] Surgery. 2007 Mar;141(3):413 [17349854.001]
  • [CommentIn] Surgery. 2006 Mar;139(3):363-4 [16546501.001]
  • (PMID = 16546500.001).
  • [ISSN] 0039-6060
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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75. Chen HC, Jen YM, Wang CH, Lee JC, Lin YS: Etiology of vocal cord paralysis. ORL J Otorhinolaryngol Relat Spec; 2007;69(3):167-71
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  • In males, neoplasm was the most common cause occurring in 63 of 176 males, whereas surgery was most frequent in 59 of 115 females.
  • The possibility of a neoplasm must be ruled out before VCP is labeled idiopathic.
  • A benign thyroid tumor could also cause VCP.
  • Besides, radiation-induced cranial nerve paralysis in head and neck cancer may play a significant role.

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  • [Copyright] Copyright (c) 2007 S. Karger AG, Basel.
  • (PMID = 17264533.001).
  • [ISSN] 0301-1569
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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76. Cioffi JA, Yue WY, Mendolia-Loffredo S, Hansen KR, Wackym PA, Hansen MR: MicroRNA-21 overexpression contributes to vestibular schwannoma cell proliferation and survival. Otol Neurotol; 2010 Dec;31(9):1455-62
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  • BACKGROUND: Vestibular schwannomas are benign tumors that arise from the vestibular nerve.
  • Left untreated, VSs can result in hearing loss, tinnitus, vestibular dysfunction, trigeminal nerve dysfunction, and can even become life threatening.
  • RESULTS: We found consistent overexpression of miR-21 when compared with normal vestibular nerve tissue.

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  • (PMID = 20856158.001).
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  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] ENG
  • [Grant] United States / NIDCD NIH HHS / DC / DC009801-03; United States / NIDCD NIH HHS / DC / K08DC006211; United States / NIDCD NIH HHS / DC / R01 DC002971; United States / NIDCD NIH HHS / DC / DC006211-05; United States / NIDCD NIH HHS / DC / K08 DC006211-05; United States / NIDCD NIH HHS / DC / R01DC02971; United States / NIDCD NIH HHS / DC / R01 DC009801; United States / NIDCD NIH HHS / DC / R01 DC009801-03; United States / NIDCD NIH HHS / DC / DC002971-14; United States / NIDCD NIH HHS / DC / R01 DC002971-14; United States / NIDCD NIH HHS / DC / K08 DC006211
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MIRN21 microRNA, human; 0 / MicroRNAs; 0 / RNA, Messenger; 0 / RNA, Neoplasm; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
  • [Other-IDs] NLM/ NIHMS237186; NLM/ PMC2978772
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77. Orhan Z, Oktas B, Yildirim U: An unusual presentation of peroneal neuropathy secondary to pigmented villonodular synovitis: a case report. Knee Surg Sports Traumatol Arthrosc; 2009 May;17(5):518-20
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  • Pigmented villonodular synovitis (PVS) is a benign proliferative disorder of unknown origin that affects synovial joints, most commonly the knee.
  • Although this disease is categorized as an inflammatory process rather than a neoplasm, it may be locally destructive and involve muscles, tendons, bone and skin.
  • [MeSH-minor] Humans. Knee Joint / pathology. Knee Joint / surgery. Magnetic Resonance Imaging. Male. Middle Aged. Orthopedic Procedures / methods. Peroneal Nerve / pathology. Peroneal Nerve / surgery

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  • [Cites] Knee. 2007 Oct;14 (5):390-4 [17600720.001]
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  • (PMID = 19205665.001).
  • [ISSN] 1433-7347
  • [Journal-full-title] Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
  • [ISO-abbreviation] Knee Surg Sports Traumatol Arthrosc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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78. Vered M, Carpenter WM, Buchner A: Granular cell tumor of the oral cavity: updated immunohistochemical profile. J Oral Pathol Med; 2009 Jan;38(1):150-9
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  • BACKGROUND: Granular cell tumor (GCT) is a benign lesion that occurs at different body sites with preponderance to the oral cavity.
  • Furthermore, GCTs could be regarded as lesions that reflect a local metabolic or reactive change rather than a true neoplasm.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Biomarkers, Tumor / analysis. Calbindin 2. Cell Nucleus / pathology. Cell Shape. Child. Female. Humans. Immunohistochemistry. Inhibins / analysis. Macrophages / pathology. Male. Membrane Glycoproteins. Middle Aged. Nerve Tissue Proteins / analysis. Receptors, Nerve Growth Factor / analysis. S100 Calcium Binding Protein G / analysis. S100 Proteins / analysis. Tongue Neoplasms / pathology. Ubiquitin Thiolesterase / analysis. Vimentin / analysis. Young Adult. gp100 Melanoma Antigen

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  • (PMID = 19192059.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CALB2 protein, human; 0 / CD68 antigen, human; 0 / Calbindin 2; 0 / Membrane Glycoproteins; 0 / NGFR protein, human; 0 / Nerve Tissue Proteins; 0 / PMEL protein, human; 0 / Receptors, Nerve Growth Factor; 0 / S100 Calcium Binding Protein G; 0 / S100 Proteins; 0 / Vimentin; 0 / gp100 Melanoma Antigen; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins; EC 3.1.2.15 / UCHL1 protein, human; EC 3.1.2.15 / Ubiquitin Thiolesterase
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79. Suehiro K, Pritzwald-Stegmann P, Lee KM, Teoh HH, Alison PM: Mediastinal and pulmonary metastases of malignant ossifying fibromyxoid tumor. Ann Thorac Surg; 2006 Jun;81(6):2289-91
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  • Ossifying fibromyxoid tumor is usually a benign tumor.
  • [MeSH-minor] Adult. Brain Neoplasms / complications. Brain Neoplasms / secondary. Diagnostic Errors. Fatal Outcome. Female. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / surgery. Humans. Lipoma / diagnosis. Neoplasm Invasiveness. Pericardium / pathology. Pericardium / surgery. Phrenic Nerve / pathology. Phrenic Nerve / surgery. Pneumonectomy. Radiotherapy, Adjuvant. Reoperation. Seizures / etiology. Skin Neoplasms / pathology. Skin Neoplasms / surgery. Superior Vena Cava Syndrome / etiology

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  • (PMID = 16731174.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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80. Meller I, Weinbroum A, Bickels J, Dadia S, Nirkin A, Merimsky O, Issakov J, Flusser G, Marouani N, Cohen N, Kollender Y: Fifteen years of bone tumor cryosurgery: a single-center experience of 440 procedures and long-term follow-up. Eur J Surg Oncol; 2008 Aug;34(8):921-7
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  • Two-thirds of the series comprised a variety of primary benign-aggressive and low-grade malignant lesions, and one-third were primary high-grade and metastatic bone tumors.
  • There were three cases of transient nerve palsies in areas other than the sacrum, and four cases of late osteoarthritis of an adjacent joint.
  • [MeSH-major] Bone Neoplasms / surgery. Cryosurgery. Neoplasm Recurrence, Local

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  • (PMID = 18158228.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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81. Schoemaker MJ, Swerdlow AJ, Auvinen A, Christensen HC, Feychting M, Johansen C, Klaeboe L, Lönn S, Salminen T, Tynes T: Medical history, cigarette smoking and risk of acoustic neuroma: an international case-control study. Int J Cancer; 2007 Jan 1;120(1):103-10
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  • Acoustic neuroma (vestibular schwannoma) is a benign tumor of the vestibulocochlear nerve.
  • Risk was not associated with a history of allergic disease, past head injury, past diagnosis of a neoplasm or birth characteristics, but was significantly raised for past diagnosis of epilepsy (OR = 2.5, 95% CI: 1.3-4.9).


82. Kawamura K, Yajima H, Morishita T, Honoki K, Takakura Y: Plexiform schwannoma of the ulnar nerve. Scand J Plast Reconstr Surg Hand Surg; 2005;39(2):120-2
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  • [Title] Plexiform schwannoma of the ulnar nerve.
  • Plexiform schwannoma is a rare benign neurogenic tumour; we report a case that arose in the ulnar nerve of a 59-year-old woman.
  • Exploration showed a continuous multinodular tumour that involved the ulnar nerve from the hand to the upper arm; the length of the tumour was 35 cm.

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  • (PMID = 16019742.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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83. Nascimento AF, Fletcher CD: The controversial nosology of benign nerve sheath tumors: neurofilament protein staining demonstrates intratumoral axons in many sporadic schwannomas. Am J Surg Pathol; 2007 Sep;31(9):1363-70
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  • [Title] The controversial nosology of benign nerve sheath tumors: neurofilament protein staining demonstrates intratumoral axons in many sporadic schwannomas.
  • Schwannomas are benign peripheral nerve sheath tumors believed to be composed purely of cells with ultrastructural features of Schwann cells; these tumors are believed to develop eccentrically from the surface of nerves and not to contain axons, other than immediately beneath the capsule.
  • [MeSH-minor] Cell Differentiation. Cell Proliferation. Diagnosis, Differential. Humans. Immunohistochemistry. Neoplasm Invasiveness. Predictive Value of Tests. Reproducibility of Results

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  • (PMID = 17721192.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neurofilament Proteins; 0 / S100 Proteins
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84. Prado JD, Andrade RG, Silva-Sousa YT, Andrade MF, Soares FA, Perez DE: Nerve sheath myxoma of the gingiva: report of a rare case and review of the literature. J Periodontol; 2007 Aug;78(8):1639-43
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  • [Title] Nerve sheath myxoma of the gingiva: report of a rare case and review of the literature.
  • BACKGROUND: Nerve sheath myxoma (NSM) is an extremely rare benign neoplasm in the oral cavity.
  • [MeSH-major] Gingival Neoplasms / diagnosis. Myxoma / diagnosis. Nerve Sheath Neoplasms / diagnosis

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  • (PMID = 17668985.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S100 Proteins; 0 / Vimentin
  • [Number-of-references] 28
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85. Hong R, Lim SC: Granular cell tumor of the cecum with extensive hyalinization and calcification: a case report. World J Gastroenterol; 2009 Jul 14;15(26):3315-8
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  • A granular cell tumor (GCT) is a benign neoplasm of unclear histogenesis that is generally believed to be of nerve sheath origin.
  • Immunohistochemical profiles did not confirm any particular cell type for the histogenetic origin of the GCT, including a nerve sheath origin.
  • Extensive hyalinization and calcification showing involution of tumor cells suggest benign clinical behavior of GCT.

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  • (PMID = 19598311.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
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  • [Other-IDs] NLM/ PMC2710791
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86. Lehnhardt M, Daigeler A, Homann HH, Hauser J, Langer S, Steinsträsser L, Soimaru C, Puls A, Steinau HU: [Importance of specialized centers in diagnosis and treatment of extremity-soft tissue sarcomas. Review of 603 cases]. Chirurg; 2009 Apr;80(4):341-7
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  • In the eight most frequent sarcoma types, malignant peripheral nerve sheath tumors and leiomyosarcoma had the highest rates of false primary diagnosis, 78.4% and 74.2% of cases, respectively.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Child. Combined Modality Therapy. Diagnostic Errors. Female. Germany. Histiocytoma, Benign Fibrous / diagnosis. Histiocytoma, Benign Fibrous / pathology. Histiocytoma, Benign Fibrous / surgery. Humans. Leiomyosarcoma / diagnosis. Leiomyosarcoma / pathology. Leiomyosarcoma / surgery. Liposarcoma / diagnosis. Liposarcoma / pathology. Liposarcoma / surgery. Male. Middle Aged. Neoplasm Staging. Nerve Sheath Neoplasms / diagnosis. Nerve Sheath Neoplasms / pathology. Nerve Sheath Neoplasms / surgery. Radiotherapy, Adjuvant. Referral and Consultation. Retrospective Studies. Young Adult

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  • (PMID = 18523742.001).
  • [ISSN] 1433-0385
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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87. Chakrabarti S, Bera M, Bhattacharya PK, Chakrabarty D, Manna AK, Pathak S, Maiti K: Study of salivary gland lesions with fine needle aspiration cytology and histopothology along with immunohistochemistry. J Indian Med Assoc; 2010 Dec;108(12):833-6
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  • Acute and chronic sialadenitis, different benign and malignant neoplasms are the common causes which present with salivary gland swelling.
  • Pre-operative core needle biopsy is hazardous and may damage facial nerve, lead to fistula formation or associated with tumour seeding.
  • Among these 3 cases, 2 were adenoid cystic carcinoma which was cytologically diagnosed as benign neoplasm (monomorphic adenoma).
  • This study corroborates well with other studies including immunohistochemical findings. p53 expression was found to be related with nature of the neoplasm.

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  • (PMID = 21661459.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] India
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88. Pata YS, Akbaş Y, Unal M, Tataroğlu C: A case of intranasal schwannoma with bilateral nasal polyposis. Kulak Burun Bogaz Ihtis Derg; 2005;15(1-2):45-8
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  • Schwannoma is a benign neoplasm originating from schwann cells of the peripheral nerve sheath, and its occurrence in the nasal cavity and paranasal sinuses is rare.

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  • (PMID = 16340292.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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89. Tse GM, Tan PH, Moriya T: The role of immunohistochemistry in the differential diagnosis of papillary lesions of the breast. J Clin Pathol; 2009 May;62(5):407-13
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  • Correct diagnosis is crucial but may be difficult, as many benign and malignant papillary lesions have similar appearances.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Carcinoma, Intraductal, Noninfiltrating / diagnosis. Diagnosis, Differential. Female. Humans. Keratins / analysis. Neoplasm Proteins / analysis. Nerve Tissue Proteins / analysis

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  • (PMID = 19126567.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Nerve Tissue Proteins; 68238-35-7 / Keratins
  • [Number-of-references] 33
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90. Upadhyaya M, Kluwe L, Spurlock G, Monem B, Majounie E, Mantripragada K, Ruggieri M, Chuzhanova N, Evans DG, Ferner R, Thomas N, Guha A, Mautner V: Germline and somatic NF1 gene mutation spectrum in NF1-associated malignant peripheral nerve sheath tumors (MPNSTs). Hum Mutat; 2008 Jan;29(1):74-82
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  • [Title] Germline and somatic NF1 gene mutation spectrum in NF1-associated malignant peripheral nerve sheath tumors (MPNSTs).
  • About 10% of neurofibromatosis type 1 (NF1) patients develop malignant peripheral nerve sheath tumors (MPNSTs) and represent considerable patient morbidity and mortality.
  • The high prevalence (>90%) of such deletions in MPNST contrast with the =or<20% found in benign neurofibromas and is indicative of the involvement of different mutational mechanisms in these tumors.
  • [MeSH-major] Germ-Line Mutation. Mutation. Nerve Sheath Neoplasms / genetics. Neurofibromin 1 / genetics. Peripheral Nervous System Neoplasms / genetics
  • [MeSH-minor] Adult. DNA Mutational Analysis. DNA, Neoplasm / metabolism. Humans. Loss of Heterozygosity. Lymphocytes / metabolism. Sequence Deletion. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 / metabolism

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17960768.001).
  • [ISSN] 1098-1004
  • [Journal-full-title] Human mutation
  • [ISO-abbreviation] Hum. Mutat.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Neurofibromin 1; 0 / Tumor Suppressor Protein p53
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91. Persaud R, Tudge S, Amonoo-Kuofi K, Beale T, O'Flynn P: Parapharyngeal granular cell tumour: a unique surgical challenge. J Laryngol Otol; 2005 Jan;119(1):68-70
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  • A granular cell tumour is a rare lesion of probable nerve sheath origin.
  • It is typically benign but up to seven per cent may be malignant.
  • The authors report a case of a 49-year-old African woman with an oro-naso-parapharyngeal granular cell neoplasm causing mild dysphagia.

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  • (PMID = 15807973.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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92. Thway K, Fisher C, Debiec-Rychter M, Calonje E: Claudin-1 is expressed in perineurioma-like low-grade fibromyxoid sarcoma. Hum Pathol; 2009 Nov;40(11):1586-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Perineurioma is a peripheral nerve sheath neoplasm, which is usually benign.
  • [MeSH-major] Biomarkers, Tumor / analysis. Fibrosarcoma / pathology. Membrane Proteins / biosynthesis. Nerve Sheath Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19540561.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CLDN1 protein, human; 0 / Claudin-1; 0 / Membrane Proteins; 0 / Mucin-1
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93. Sabir Husin Athar PP, Yahya Z, Mat Baki M, Abdullah A: Facial nerve paralysis: a rare complication of parotid abscess. Malays J Med Sci; 2009 Apr;16(2):38-9
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  • [Title] Facial nerve paralysis: a rare complication of parotid abscess.
  • Benign parotid neoplasm and inflammatory processes of the parotid resulting in facial paralysis are extremely rare.
  • We report a 72-year-old Malay female with poorly-controlled diabetes mellitus who presented with a painful right parotid swelling associated with right facial nerve palsy.

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  • (PMID = 22589657.001).
  • [ISSN] 1394-195X
  • [Journal-full-title] The Malaysian journal of medical sciences : MJMS
  • [ISO-abbreviation] Malays J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
  • [Other-IDs] NLM/ PMC3336167
  • [Keywords] NOTNLM ; facial nerve injuries / neurosciences / parotid neoplasms / parotitis
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94. Sato K, Ueda Y, Miwa S, Yokogawa A, Ozaki M, Katsuda S: Low-grade malignant soft-tissue perineurioma: interphase fluorescence in situ hybridization. Pathol Int; 2008 Nov;58(11):718-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Perineuriomas are usually benign soft-tissue tumors that arise from perineurial cells of the peripheral nerve sheath.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Cell Nucleus / chemistry. Cell Nucleus / pathology. Chromosome Aberrations. Chromosomes, Human, Pair 13. Claudin-1. DNA, Neoplasm / analysis. Glucose Transporter Type 1 / analysis. Humans. In Situ Hybridization, Fluorescence. Ki-67 Antigen / analysis. Male. Membrane Proteins / analysis. Middle Aged. Mitosis. Mucin-1 / analysis. Treatment Outcome. Wrist / surgery

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  • (PMID = 18844938.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CLDN1 protein, human; 0 / Claudin-1; 0 / DNA, Neoplasm; 0 / Glucose Transporter Type 1; 0 / Ki-67 Antigen; 0 / Membrane Proteins; 0 / Mucin-1
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95. Iwai Y, Yamanaka K, Kubo T, Aiba T: Gamma knife radiosurgery for intracanalicular acoustic neuromas. J Clin Neurosci; 2008 Sep;15(9):993-7
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  • No patients experienced post-radiosurgery facial palsy or other cranial nerve deficits.
  • When determining treatment for intracanalicular acoustic neuromas, the condition's benign natural course and the likelihood of hearing preservation must be taken into account.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neuroma, Acoustic / surgery. Radiosurgery / methods. Radiosurgery / standards. Vestibulocochlear Nerve / surgery. Vestibulocochlear Nerve Diseases / surgery
  • [MeSH-minor] Adult. Aged. Disease Progression. Ear, Inner / pathology. Ear, Inner / surgery. Female. Hearing Loss, Sensorineural / etiology. Hearing Loss, Sensorineural / prevention & control. Hearing Loss, Sensorineural / surgery. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Petrous Bone / pathology. Petrous Bone / surgery. Postoperative Complications / etiology. Postoperative Complications / prevention & control. Radiation Dosage. Treatment Outcome

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  • (PMID = 18617402.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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96. Alpízar-Aguirre A, Zárate-Kalfópulos B, Rosales-Olivares LM, Baena-Ocampo Ldel C, Reyes-Sánchez AA: [Vertebral hemangioma of the posterior arch with subsequent extraosseous extension and neurological symptoms. Case report and literature review]. Cir Cir; 2009 Mar-Apr;77(2):127-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Vertebral hemangioma is the most common benign spinal tumor and is found in 11% of postmortem studies as a slow-growing benign vascular malformation.
  • CONCLUSIONS: Vertebral hemangioma is normally an asymptomatic benign lesion not requiring specific treatment.
  • [MeSH-major] Hemangioma / complications. Hemangioma / pathology. Nerve Compression Syndromes / etiology. Spinal Cord Neoplasms / complications. Spinal Cord Neoplasms / pathology. Spinal Neoplasms / complications. Spinal Neoplasms / pathology
  • [MeSH-minor] Adolescent. Female. Humans. Neoplasm Invasiveness

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  • (PMID = 19534864.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Mexico
  • [Number-of-references] 28
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97. Busam KJ: Cutaneous desmoplastic melanoma. Adv Anat Pathol; 2005 Mar;12(2):92-102
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  • It may simulate histologically sclerosing melanocytic nevi as well as various benign and malignant nonmelanocytic lesions.
  • Some tumors show neuroma-like features with prominent nerve involvement, in which case the term "desmoplastic neurotropic melanoma" is used.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Fibrosis. Humans. Neoplasm Recurrence, Local. Nevus, Pigmented / diagnosis. S100 Proteins / analysis. Sunlight / adverse effects

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  • (PMID = 15731577.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins
  • [Number-of-references] 56
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98. Charpiot A, Tringali S, Zaouche S, Ferber-Viart C, Dubreuil C: Perioperative complications after translabyrinthine removal of large or giant vestibular schwannoma: Outcomes for 123 patients. Acta Otolaryngol; 2010 Nov;130(11):1249-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CONCLUSION: Large vestibular schwannomas are benign but dangerous tumors.
  • In all, 4.9% of patients underwent a second surgery (for delayed hemorrhage or cerebrospinal fluid leak) during the first months after removal of a large vestibular schwannoma; 3.2% of patients experienced definitive neurologic complications (one death, one cerebellar disturbance, and two cases of 10th cranial nerve palsy).
  • [MeSH-minor] Adult. Aged. Aphasia / etiology. Brain Stem / pathology. Cerebrospinal Fluid Leak. Cerebrospinal Fluid Rhinorrhea / etiology. Edema / etiology. Electromyography. Epilepsy / etiology. Facial Nerve / physiopathology. Female. Follow-Up Studies. Hematoma, Subdural / etiology. Hematoma, Subdural / surgery. Humans. Magnetic Resonance Imaging. Male. Meningitis / etiology. Middle Aged. Neoplasm Staging. Nervous System Diseases / etiology. Retrospective Studies. Survival Rate. Treatment Outcome

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  • [CommentIn] Acta Otolaryngol. 2011 Nov;131(11):1237-8 [21728749.001]
  • (PMID = 20443757.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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99. Sturgeon BP, Milne EM, Smith KC: Benign peripheral nerve sheath tumor of the perianal region in a young pony. J Vet Diagn Invest; 2008 Jan;20(1):93-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign peripheral nerve sheath tumor of the perianal region in a young pony.
  • On the basis of the histopathology and immunohistochemistry, a diagnosis of benign peripheral nerve sheath tumor (schwannoma type) was made.
  • This case was unusual in that the concentric laminations of Schwann cells were very loosely arranged, with an intervening myxomatous stroma (Antoni type B appearance) and despite its benign histological appearance, the mass extended deeply to the proximal sacral vertebrae.
  • [MeSH-major] Anus Neoplasms / veterinary. Horse Diseases / pathology. Nerve Sheath Neoplasms / veterinary
  • [MeSH-minor] Animals. Horses. Immunohistochemistry / veterinary. Male. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / veterinary

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  • (PMID = 18182519.001).
  • [ISSN] 1040-6387
  • [Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • [ISO-abbreviation] J. Vet. Diagn. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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