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1. Carinci F, Piattelli A, Martinelli M, Palmieri A, Rubini C, Fioroni M, Scapoli L, Laino G, Caputi S, Becchetti A, Pezzetti F: Genetic profiling of central giant cell granuloma of the jaws. J Craniofac Surg; 2005 May;16(3):399-407
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  • Whether CGCG is a reactive lesion or a truly benign neoplasm remains undetermined, and the mechanism determining the onset of the disease remains unknown.
  • RNA extracted from a pool of three normal bone tissues was used as control.

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  • (PMID = 15915104.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Genetic Markers
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2. Franceschi F, Marinozzi A, Rizzello G, Papalia R, Rojas M, Denaro V: Computed tomography-guided and arthroscopically controlled en bloc retrograde resection of a juxta-articular osteoid osteoma of the tibial plateau. Arthroscopy; 2005 Mar;21(3):351-9
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  • Osteoid osteoma represents approximately 10% to 11% of all the benign bone tumors.
  • The lesion was removed by a rear-entry computed tomography (CT)-guided drill under arthroscopic control and the bony defect filled with bone graft harvested from the proximal tibial metaphysis.
  • The follow-up CT scan 2 years after surgery showed complete excision of the lesion and perfect positioning of the bone graft.
  • [MeSH-major] Arthroscopy / methods. Bone Neoplasms / surgery. Knee Joint / surgery. Osteoma, Osteoid / radiography. Osteoma, Osteoid / surgery. Tibia / surgery. Tomography, X-Ray Computed / methods

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  • (PMID = 15756191.001).
  • [ISSN] 1526-3231
  • [Journal-full-title] Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
  • [ISO-abbreviation] Arthroscopy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Sadeghi-Azandaryani M, Mendl N, Rademacher A, Hoffmann U, Steckmeier B, Heyn J: Pseudoaneurysm of the popliteal artery due to osteochondroma of the distal femur. Vasa; 2010 Aug;39(3):274-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteochondroma is the most common type of benign bone tumour, and is most often found in the knee region.
  • The lesion is usually clinically silent although it may cause different complications such as fractures of the tumour, bone deformities, neurological disorders, malignant transformation and in rare cases vascular disorders.
  • A delay in diagnosis especially of pseudoaneurysm formation may result in life-threatening situations, extensive operations and lengthy hospital stays.

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  • (PMID = 20737389.001).
  • [ISSN] 0301-1526
  • [Journal-full-title] VASA. Zeitschrift für Gefässkrankheiten
  • [ISO-abbreviation] VASA
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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4. Geniets C, Vanhoenacker FM, Van de Perre S, Van Dyck P, Gielen J, De Schepper AM, Parizel PM: Proceedings of the European Society of Musculoskeletal Radiology (ESSR) training module, Antwerp, 20-21.01.05. Part two: bone tumors. Benign bone lesions: characteristic imaging features. JBR-BTR; 2006 Sep-Oct;89(5):266-74
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  • [Title] Proceedings of the European Society of Musculoskeletal Radiology (ESSR) training module, Antwerp, 20-21.01.05. Part two: bone tumors. Benign bone lesions: characteristic imaging features.
  • Benign bone lesions are a fairly common finding in radiology practice.
  • Often, the combination of patient's age and plain radiographic findings are sufficient for diagnosis and obviates the need for further imaging.
  • Generally the following parameters should be assessed in the evaluation of a bone lesion: clinical features, age of the patient, location, size, pattern of bone destruction, cortical involvement, zone of transition, sclerotic margination and matrix calcification.
  • This article reviews the spectrum of clinical and imaging appearances of the most common benign bone tumors.
  • [MeSH-major] Bone Diseases / diagnosis. Bone Neoplasms / diagnosis. Magnetic Resonance Imaging. Radiology. Societies, Medical. Tomography, X-Ray Computed
  • [MeSH-minor] Bone and Bones / pathology. Humans

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  • (PMID = 17147017.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Congresses
  • [Publication-country] Belgium
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5. Simonetti S, Mignogna C, La Mantia V, Lanza F, Insabato L: Primary intraosseous cavernous hemangioma of the metacarpal bone: a very rare entity. Case report. Tumori; 2009 Jan-Feb;95(1):101-3
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  • [Title] Primary intraosseous cavernous hemangioma of the metacarpal bone: a very rare entity. Case report.
  • Intraosseous cavernomas are very rare benign lesions representing less than 1% of all skeletal tumors and most frequently observed in vertebrae and head and neck bones.
  • We report a case of this neoplasm in the distal epiphysis of the third metacarpal bone in a 68-year-old man, along with the clinicopathological findings.
  • The differential diagnosis and a review of the literature are discussed.
  • [MeSH-major] Bone Neoplasms / pathology. Hemangioma, Cavernous / pathology. Metacarpal Bones / pathology

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  • (PMID = 19366066.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Lim ZY, Ingram W, Brand R, Akthari M, Milojkovic D, Ho AY, Devereux S, Pagliuca A, Duarte RF, Mufti GJ: Clonal gammopathies following alemtuzumab-based reduced intensity conditioning haematopoietic stem cell transplantation: association with chronic graft-versus-host disease and improved overall survival. Bone Marrow Transplant; 2007 Oct;40(8):747-52
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  • On multivariate analysis, the only factors that were found to influence overall survival (OS) were presence of gammopathies, which was associated with an improved OS (OR 0.35 95% CI 0.14-0.86, P=0.02) as well as disease stage, patients with advanced disease having a higher risk of death (OR 2.20 95% CI 1.18-4.11, P=0.02).
  • Clonal gammopathies are a frequent but benign occurrence following alemtuzumab-based RIC HSCT, and their appearance may define a group of patients with a favourable overall outcome.
  • [MeSH-major] Antibodies, Monoclonal / administration & dosage. Antibodies, Neoplasm / administration & dosage. Graft vs Host Disease / etiology. Hematopoietic Stem Cell Transplantation / adverse effects. Monoclonal Gammopathy of Undetermined Significance / etiology

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  • [CommentIn] Bone Marrow Transplant. 2008 Feb;41(3):317 [17982492.001]
  • (PMID = 17704796.001).
  • [ISSN] 0268-3369
  • [Journal-full-title] Bone marrow transplantation
  • [ISO-abbreviation] Bone Marrow Transplant.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antibodies, Neoplasm; 3A189DH42V / alemtuzumab
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7. Domovitov SV, Healey JH: Primary malignant giant-cell tumor of bone has high survival rate. Ann Surg Oncol; 2010 Mar;17(3):694-701
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  • [Title] Primary malignant giant-cell tumor of bone has high survival rate.
  • BACKGROUND: Malignant giant-cell tumors (MGCT) comprise 2-9% of all giant-cell tumors (GCTs).
  • This study compared malignant to benign GCTs and defined the clinical outcome of the patients in a large series of case-matched patients from a single institution.
  • METHODS: Clinical, radiological, and outcome features were compared between 26 malignant and 244 benign GCTs treated in our institution.
  • We also performed a 1:2 case-matched comparison of patients with malignant and benign disease.
  • Campanacci stage 1 tumors had a low probability of malignancy (P = 0.017).
  • MGCT were less likely to have aneurysmal bone cyst changes.
  • The 5-year recurrence-free status probability was 80% for malignant and 91% for benign cases in matched groups.
  • The difference in the recurrence rate between benign and malignant groups was not statistically significant (P = 0.24).
  • Functional impairment and limited activity were greater in MGCT patients than in benign GCT patients, whether treated by resection/amputation or curettage/cryosurgery.
  • CONCLUSIONS: We found that malignant and benign GCT have similar epidemiology and that recurrence was higher in MGCT (20 v 9%).
  • [MeSH-major] Bone Neoplasms / mortality. Giant Cell Tumor of Bone / mortality. Neoplasm Recurrence, Local / mortality

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  • (PMID = 19902306.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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8. Moh EN, Aguehoundé C, Aké YL, Kéita A, Kotaix L: [Reconstruction using non-vascularized fibula of an aneurysmal bone cyst of the humerus in a child]. Mali Med; 2010;25(1):64-5
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  • [Title] [Reconstruction using non-vascularized fibula of an aneurysmal bone cyst of the humerus in a child].
  • [Transliterated title] Reconstruction par Fibula non Vascularisee d'un Kyste Osseux Anevrysmal de L'Humerus Chez L'Enfant.
  • Aneurysmal bone cyst is a pseudotumoral bone dystrophy which accounts for 1.5 to 4% of benign bone tumours.
  • [MeSH-major] Bone Cysts, Aneurysmal / surgery. Fibula / transplantation. Humerus / surgery

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  • (PMID = 21436008.001).
  • [ISSN] 1993-0836
  • [Journal-full-title] Le Mali médical
  • [ISO-abbreviation] Mali Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mali
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9. Leiblich A, Cross SS, Catto JW, Phillips JT, Leung HY, Hamdy FC, Rehman I: Lactate dehydrogenase-B is silenced by promoter hypermethylation in human prostate cancer. Oncogene; 2006 May 11;25(20):2953-60
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  • In tissues, LDHB promoter hypermethylation occurred at a higher frequency in prostate cancer, 14/ 31 (45%), compared to adjacent nonmalignant or benign tissue, 2/19 (11%) (P < 0.025).
  • Immunohistochemistry showed a higher frequency of LDHB expression in benign or non-malignant tissues, 59/ 73 (81%), compared to cancer cases, 3/53 (6%) (P < 0.001).
  • Absent LDHB expression was also seen in 7/7 (100%) cases of metastatic cancer in bone.
  • [MeSH-major] Bone Neoplasms / genetics. DNA Methylation. Gene Silencing. L-Lactate Dehydrogenase / genetics. Promoter Regions, Genetic / genetics. Prostatic Neoplasms / genetics
  • [MeSH-minor] Amino Acid Sequence. Azacitidine / analogs & derivatives. Azacitidine / pharmacology. Base Sequence. DNA Modification Methylases / antagonists & inhibitors. DNA, Neoplasm / genetics. Electrophoresis, Gel, Two-Dimensional. Enzyme Inhibitors / pharmacology. Gene Expression Regulation, Neoplastic. Humans. Isoenzymes / deficiency. Isoenzymes / genetics. Male. Molecular Sequence Data. Proteomics. Tumor Cells, Cultured / drug effects. Tumor Cells, Cultured / metabolism


10. Yoshida T, Sakamoto A, Tanaka K, Matsuda S, Oda Y, Iwamoto Y: Alternative surgical treatment for giant-cell reparative granuloma in the metacarpal, using phenol and ethanol adjuvant therapy. J Hand Surg Am; 2007 Jul-Aug;32(6):887-92
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  • Giant-cell reparative granuloma (GCRG) or a solid variant of an aneurysmal bone cyst (ABC) is an uncommon benign reactive lesion with a predilection for the small tubular bones of the hands and feet.
  • Adjuvant therapy usually is applied to reduce the recurrence of locally aggressive bone tumors.
  • We report 2 cases of GCRG that were treated successfully with curettage, adjuvant phenol and ethanol, and autogenous bone grafting.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Bone Diseases / therapy. Ethanol / therapeutic use. Granuloma, Giant Cell / therapy. Metacarpal Bones / surgery. Phenol / therapeutic use
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Child. Curettage. Female. Humans. Ilium / transplantation. Male. Neoplasm Recurrence, Local / prevention & control

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  • (PMID = 17606072.001).
  • [ISSN] 0363-5023
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 339NCG44TV / Phenol; 3K9958V90M / Ethanol
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11. Saglik Y, Altay M, Unal VS, Basarir K, Yildiz Y: Manifestations and management of osteochondromas: a retrospective analysis of 382 patients. Acta Orthop Belg; 2006 Dec;72(6):748-55
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  • Osteochondromas represent the most common primary bone tumours; they reportedly represent 20-50% of all benign bone tumours and 10-15% of all bone tumours.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Osteochondroma / diagnosis. Osteochondroma / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Exostoses, Multiple Hereditary / complications. Exostoses, Multiple Hereditary / diagnosis. Exostoses, Multiple Hereditary / surgery. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 17260614.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
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12. Azorín D, González-Mediero I, Colmenero I, De Prada I, López-Barea F: Diaphyseal chondroblastoma in a long bone: first report. Skeletal Radiol; 2006 Jan;35(1):49-52
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  • [Title] Diaphyseal chondroblastoma in a long bone: first report.
  • Chondroblastoma is a rare benign bone tumor typically located in the epiphysis.
  • We describe the first case of chondroblastoma arising in the diaphysis of a long bone.

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  • (PMID = 16010594.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
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  • [Language] eng
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13. Toy PC, White JR, Scarborough MT, Enneking WF, Gibbs CP: Distal femoral osteoarticular allografts: long-term survival, but frequent complications. Clin Orthop Relat Res; 2010 Nov;468(11):2914-23
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  • METHODS: We retrospectively reviewed 26 patients who had osteoarticular allograft reconstruction of the distal femur after resection of a malignant or aggressive benign tumor of bone.
  • Lacking the benefit of improved soft tissue attachments inherent in other anatomic sites, we believe this option is most appropriate for restoring bone stock in young patients with expectations of long-term survival.
  • [MeSH-major] Bone Transplantation / adverse effects. Femoral Neoplasms / surgery. Femur / surgery. Graft Survival
  • [MeSH-minor] Adolescent. Adult. Amputation. Child. Female. Humans. Kaplan-Meier Estimate. Limb Salvage. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Recovery of Function. Reoperation. Retrospective Studies. Time Factors. Transplantation, Homologous. Treatment Outcome. Young Adult

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  • (PMID = 20645036.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2947705
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14. Weber KL, Peabody T, Frassica FJ, Mott MP, Parsons TW 3rd: Tumors for the general orthopedist: how to save your patients and practice. Instr Course Lect; 2010;59:579-91
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  • [Title] Tumors for the general orthopedist: how to save your patients and practice.
  • It is likely that most orthopaedic surgeons will see a patient with a benign or malignant musculoskeletal tumor sometime during their career.
  • However, because of the rarity of these entities, many surgeons may benefit from a review of how to evaluate a patient with a bone lesion or soft-tissue mass.
  • A logical approach is necessary in evaluating imaging studies as well as in the workup of children and adults with a possible tumor.
  • If the treatment algorithms lead to a conclusive diagnosis of a benign bone tumor, benign soft-tissue mass, or metastatic bone disease, the orthopaedic surgeon may choose to definitively treat the patient.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Cysts / diagnosis. Joint Diseases / pathology. Orthopedics. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 20415407.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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15. Hu W, Zhen X, Xiong B, Wang B, Zhang W, Zhou W: CXCR6 is expressed in human prostate cancer in vivo and is involved in the in vitro invasion of PC3 and LNCap cells. Cancer Sci; 2008 Jul;99(7):1362-9
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  • In spite of the clinical importance of prostate cancer (PCa) bone metastasis, the precise mechanisms for the directed migration of malignant cells remain unclear.
  • In the present study, the expression of CXCR6 in human PCa and benign prostatic hyperplasia samples, and the expression of CXCL16 in human osseous tissues were determined by immunohistochemistry.
  • It was found that the level of CXCR6 protein expression was elevated in human malignant prostate tumors, and CXCL16 was expressed positively by human osteocytes in vivo.
  • Our results suggest that besides CXCL12/CXCR4, CXCL16/CXCR6 might be another important factor involved in PCa bone metastasis.
  • [MeSH-minor] Aged. Bone and Bones / chemistry. Cell Line, Tumor. Chemokines, CXC / analysis. Humans. Immunohistochemistry. Male. Matrix Metalloproteinase 2 / metabolism. Matrix Metalloproteinase 9 / metabolism. Middle Aged. Neoplasm Invasiveness. Receptors, CXCR4 / analysis. Receptors, CXCR4 / genetics. Receptors, Scavenger / analysis. Reverse Transcriptase Polymerase Chain Reaction

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  • [ErratumIn] Cancer Sci. 2008 Dec;99(12):2548
  • (PMID = 18452560.001).
  • [ISSN] 1349-7006
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CXCL16 protein, human; 0 / CXCR4 protein, human; 0 / CXCR6 protein, human; 0 / Chemokines, CXC; 0 / Receptors, CXCR4; 0 / Receptors, Chemokine; 0 / Receptors, Scavenger; 0 / Receptors, Virus; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9
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16. Biswas D, Crank S: Aetiopathology of maxillary swelling--a 3-year prospective study. Eur Arch Otorhinolaryngol; 2007 Nov;264(11):1295-9
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  • A wide variety of lesions and not necessarily a malignant tumour can cause maxillary swelling.
  • Non-specificity of clinical and radiological features of these maxillary lesions makes their diagnosis difficult.
  • The awareness of the spectrum of pathology related to maxillary swelling is essential for correct diagnosis and treatment.
  • Maxillary swelling was found to be caused by malignant tumours in 54.2%, benign neoplasms in 22.9% and non-neoplastic lesions in 22.9%.
  • Overall squamous cell carcinoma (22.9%) was the commonest lesion, tumour of vascular origin was the commonest benign neoplasm and odontogenic cyst was the commonest among the non-neoplastic lesions.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Fibrous Dysplasia of Bone / complications. Humans. Male. Middle Aged. Mucocele / complications. Nasal Obstruction / complications. Odontogenic Cysts / complications. Preoperative Care. Prospective Studies. Young Adult

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  • (PMID = 17611767.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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17. Cueva del Castillo JF, Francisco Osuna J, Elizondo F, Pérez O, Pérez A, Hernández S, Mejía C: [Use of a xenoimplant for the treatment of bone defects, benign tumors, pseudoarthrosis and arthrodesis. Preliminary report]. Acta Ortop Mex; 2007 Jan-Feb;21(1):31-6
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  • [Title] [Use of a xenoimplant for the treatment of bone defects, benign tumors, pseudoarthrosis and arthrodesis. Preliminary report].
  • [Transliterated title] Aplicación de xenoimplante para el tratamiento de defectos oseos, tumores benignos, seudoartrosis y artrodesis. (Reporte preliminar).
  • OBJECTIVE: To show that the ceramic produced at the Institute for Materials Research, National Autonomous University of Mexico, is an appropriate replacement of bone graft in patients with bone tumors, benign tumors, pseudoarthrosis and arthrodesis treated at "General Ignacio Zaragoza" Regional Hospital.
  • They underwent X-ray evaluation of bone healing using the Montoya classification.
  • The most frequent indication was arthrodesis in 10 patients (45.45%), pseudoarthrosis in 6 (27.27%), benign tumors in 3 (13.63%), and bone defects in 3 (13.63%).
  • Type II to type IV bone healing was observed in the sample.
  • DISCUSSION: The use of ceramic xenoimplants is appropriate as a replacement of bone graft in patients with arthrodesis and bone defects, thus avoiding the need for autologous bone graft.
  • [MeSH-major] Arthrodesis. Bone Neoplasms / surgery. Bone Transplantation. Pseudarthrosis / surgery. Transplantation, Heterologous

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  • (PMID = 17695206.001).
  • [ISSN] 2306-4102
  • [Journal-full-title] Acta ortopédica mexicana
  • [ISO-abbreviation] Acta Ortop Mex
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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18. Miyake A, Morioka H, Yabe H, Anazawa U, Morii T, Miura K, Mukai M, Takayama S, Toyama Y: A case of metacarpal chondrosarcoma of the thumb. Arch Orthop Trauma Surg; 2006 Aug;126(6):406-10
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  • Enchondroma is the most common primary benign bone tumor of the hand.
  • It often is difficult to make a histological distinction between benign cartilaginous tumors and low-grade chondrosarcomas, because enchondromas at this site often show histological features suggestive of malignancy.
  • This is a case report of chondrosarcoma affecting the metacarcal bone of the thumb, treated by en block resection and preserving the function of the thumb by bone graft reconstruction, with reference to the literature.
  • [MeSH-major] Bone Neoplasms / surgery. Chondrosarcoma / surgery. Metacarpal Bones

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  • (PMID = 16557368.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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19. Atalar B, Miller RC, Dincbas FO, Geismar JH, Micke O, Akyurek S, Ozyar E: Adult langerhans cell histiocytosis of bones : a rare cancer network study. Acta Orthop Belg; 2010 Oct;76(5):663-8
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  • Langerhans Cell Histiocytosis (LCH) is an uncommon benign bone tumour typically seen in children.
  • The localization of tumours was skull bones in 12 (40%), lower extremity in 6 (20%), thoracic bones in 4 (133%), spine in 3 (10%), pelvis in 2 (6.7%) and multiple sites in 3 (10%) patients.
  • [MeSH-major] Bone Diseases / therapy. Histiocytosis, Langerhans-Cell / therapy


20. Jerome JT, Sankaran B, Varghese M, Thomas S, Thirumagal SK: Rare presentation of Ewing's sarcoma: a case report and literature review. J Pediatr Orthop B; 2008 Sep;17(5):261-4
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  • The clinical presentations represent a degree of overlap among various benign and infective etiologies.
  • The diagnosis was confirmed by gold standard biopsy.
  • We present a case of Ewing's tumor in a 13-year-old girl and discuss its rare presentation, and also offer a literature review.
  • [MeSH-major] Bone Neoplasms / pathology. Bone Neoplasms / therapy. Fingers. Sarcoma, Ewing / pathology. Sarcoma, Ewing / therapy
  • [MeSH-minor] Adolescent. Amputation / methods. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Neoplasm Staging. Rare Diseases. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19471180.001).
  • [ISSN] 1473-5865
  • [Journal-full-title] Journal of pediatric orthopedics. Part B
  • [ISO-abbreviation] J Pediatr Orthop B
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 9
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21. Aneiros-Fernandez J, Caba-Molina M, Arias-Santiago S, Ovalle F, Hernandez-Cortes P, Aneiros-Cachaza J: Myositis ossificans circumscripta without history of trauma. J Clin Med Res; 2010 May 19;2(3):142-4
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  • Myositis ossificans circumscripta is a form of heterotopic ossification that is benign in nature associated to a trauma, but may appear clinically and radiologically as a malignant neoplasm.
  • We discuss some of the difficulties of diagnosis and histological evolution of the lesion.
  • KEYWORDS: Myositis ossificans; Thigh; Differential diagnosis; Nontraumatic.

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  • (PMID = 21629528.001).
  • [ISSN] 1918-3011
  • [Journal-full-title] Journal of clinical medicine research
  • [ISO-abbreviation] J Clin Med Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC3104644
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22. Decock CE, Kataria S, Breusegem CM, Van Den Broecke CM, Claerhout IJ: Ectopic meningioma anterior to the lacrimal gland fossa. Ophthal Plast Reconstr Surg; 2009 Jan-Feb;25(1):57-9
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  • A 66-year-old man reported a slowly growing tumor on the lateral edge of his left upper eyelid.
  • A neoplasm of the lacrimal gland was suspected.
  • Resection of the tumor was performed, which was located just behind the orbital septum and in front of the lacrimal gland.
  • Anatomopathologic investigation of the excised specimen with immunohistochemistry revealed a benign meningioma of a meningotheliomatous type, containing multiple bone elements.
  • Therefore, it should be included in the differential diagnosis of a lacrimal gland tumor.

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  • (PMID = 19273931.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mucin-1; 0 / Vimentin
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23. Kumar A, Varshney MK, Trikha V, Rastogi S: An unusual presentation of a rare chest wall tumour: giant cell tumour of bone. Joint Bone Spine; 2007 Jan;74(1):100-2
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  • [Title] An unusual presentation of a rare chest wall tumour: giant cell tumour of bone.
  • Giant cell tumour of bone is an aggressive benign bone tumour.
  • We report a case of giant cell tumour of the anterior end of the rib masquerading as a sub-mammary abscess in lactating women.
  • [MeSH-major] Bone Neoplasms / diagnosis. Giant Cell Tumor of Bone / diagnosis. Thoracic Wall
  • [MeSH-minor] Abscess / diagnosis. Adult. Diagnosis, Differential. Female. Humans. Lactation. Treatment Outcome

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  • (PMID = 17197221.001).
  • [ISSN] 1778-7254
  • [Journal-full-title] Joint, bone, spine : revue du rhumatisme
  • [ISO-abbreviation] Joint Bone Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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24. Chen YR, Chang CN, Tan YC: Craniofacial fibrous dysplasia: an update. Chang Gung Med J; 2006 Nov-Dec;29(6):543-9
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  • Fibrous dysplasia was first described by Lichtenstein in 1938 as a disorder characterized by progressive replacement of normal bone elements by fibrous tissue.
  • It is a bone tumor that, although benign, has the potential to cause significant cosmetic and functional disturbance, particularly in the craniofacial skeleton.

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  • (PMID = 17302216.001).
  • [ISSN] 2072-0939
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China (Republic : 1949- )
  • [Number-of-references] 50
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25. Xiao H, Gong S, Nie X, Guo C, Zhong G: [Ossifying fibroma of the temporal bone]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2006 Oct;20(19):868-70
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  • [Title] [Ossifying fibroma of the temporal bone].
  • OBJECTIVE: To describe the clinical presentation of ossifying fibroma of the temporal bone, and to discuss its diagnosis and treatment.
  • METHOD: A rare case of ossifying fibroma of the temporal bone was presented.
  • Frozen section evaluation during operation was not definitive but suggested benign nature in histology.
  • The tumor was fully resected.
  • RESULT: The final pathological report indicated the stromal cells were negative for S-100 protein and epithelia membrane antigen (EMA), supporting the diagnosis of ossifying fibroma.
  • One-year follow-up showed the sealed EAC was satisfactory with complete interior and no tumor recurred.
  • CONCLUSION: Ossifying fibroma of the temporal bone is a rare entity, which is a benign neoplasm but may show an aggressive behavior by compression and encroachment upon adjacent structures.
  • [MeSH-major] Bone Neoplasms. Fibroma, Ossifying. Temporal Bone / pathology

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  • (PMID = 17168109.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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26. Prado MP, Mendes AA, Amodio DT: Benign bone tumors subperiosteal on the talar neck resected anthroscopically: case reports. Einstein (Sao Paulo); 2010 Sep;8(3):354-7
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  • [Title] Benign bone tumors subperiosteal on the talar neck resected anthroscopically: case reports.
  • Two cases of benign chondral tumors of the talar neck region (an osteoid osteoma and a chondroblastoma) were described.

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  • (PMID = 26760154.001).
  • [ISSN] 1679-4508
  • [Journal-full-title] Einstein (São Paulo, Brazil)
  • [ISO-abbreviation] Einstein (Sao Paulo)
  • [Language] eng; por
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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27. Kitsoulis P, Galani V, Stefanaki K, Paraskevas G, Karatzias G, Agnantis NJ, Bai M: Osteochondromas: review of the clinical, radiological and pathological features. In Vivo; 2008 Sep-Oct;22(5):633-46
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  • Osteochondroma is the most common benign bone tumor and usually occurs in the metaphyseal region of the long bones.
  • This tumor takes the form of a cartilage-capped bony outgrowth on the surface of the bone.
  • Approximately 15% of osteochondromas occur as multiple lesions in the context of hereditary multiple osteochondromas (HMOs), a disorder that is inherited in an autosomal dominant manner.
  • [MeSH-major] Bone Neoplasms / pathology. Bone Neoplasms / radiography. Osteochondroma / pathology. Osteochondroma / radiography

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  • (PMID = 18853760.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Greece
  • [Chemical-registry-number] EC 2.4.1.- / N-Acetylglucosaminyltransferases; EC 2.4.1.224 / exostosin-1; EC 2.4.1.224 / exostosin-2
  • [Number-of-references] 125
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28. Tanigawa N, Kariya S, Kojima H, Komemushi A, Fujii H, Sawada S: Lower limb ischaemia caused by fractured osteochondroma of the femur. Br J Radiol; 2007 Apr;80(952):e78-80
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  • Osteochondroma is the most common benign bone tumour and can arise in any bone.
  • [MeSH-major] Bone Neoplasms / complications. Exostoses, Multiple Hereditary / complications. Femoral Fractures / complications. Ischemia / etiology. Leg / blood supply


29. Abula A, Abaiyedula A, Yusufu A, Liu C, Huang H: [Preliminary clinical application of cancellous granule-type calcium phosphate cement]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2010 Sep;24(9):1100-2
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  • OBJECTIVE: To investigate the clinical efficacy of the cancellous granule-type calcium phosphate cement in repair bone defect.
  • METHODS: Between July 2008 and July 2009, 35 patients (42 limbs) with fractures, nonunion, and benign bone tumor were treated with cancellous granule-type calcium phosphate cement.
  • There were 32 males and 3 females, with an age range from 9 to 73 years (median, 41 years), including 24 limb fractures (19 cases), 4 osteotomy for deformity of ulna and radius (2 cases), 2 femur intertrochanteric bony cysts (2 cases), 3 enchondroma (3 cases), 5 bone defect at donor ilium (5 cases), 3 nonunion (3 cases), and 1 lumbar spinal stenosis (1 case).
  • The size of bone defect was 1-5 cm.
  • Bone defect was repaired with cancellous granule-type calcium phosphate cement (1-5 g).
  • Incision dehiscence occurred in 2 cases, and wounds healed after second debridement and removal of artificial bone.
  • X-ray films showed that bone graft fusion was achieved and bone defect was radically repaired at 6 months after operation and artificial bone was absorbed completely at 12 months.
  • CONCLUSION: Cancellous granule-type calcium phosphate cement can be used as a new graft bone material, which is suitable for defect filling after traumatic fracture, benign bone tumors, and iliac bone donor.
  • [MeSH-major] Bone Cements. Bone Transplantation / instrumentation. Calcium Phosphates / therapeutic use

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  • (PMID = 20939483.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Bone Cements; 0 / Calcium Phosphates; 97Z1WI3NDX / calcium phosphate
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30. Tischler V, Fritzsche FR, Wild PJ, Stephan C, Seifert HH, Riener MO, Hermanns T, Mortezavi A, Gerhardt J, Schraml P, Jung K, Moch H, Soltermann A, Kristiansen G: Periostin is up-regulated in high grade and high stage prostate cancer. BMC Cancer; 2010;10:273
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  • Metastatic prostate cancers (n = 20), hormone refractory prostate cancers (n = 19) and benign prostatic tissues (n = 38) were also analyzed.
  • RESULTS: In total, strong epithelial periostin expression was detectable in 142 of 418 (34.0%) of prostate carcinomas and in 11 of 38 benign prostate glands (28.9%).
  • Increased periostin expression in carcinoma cells was significantly associated with high Gleason score (p < 0.01) and advanced tumour stage (p < 0.05) in the test cohort.
  • Whereas periostin expression was weak or absent in the stroma around normal prostate glands, strong periostin expression in tumour stroma was found in most primary and metastatic prostate cancers.
  • CONCLUSIONS: Our data indicate that periostin up-regulation is related to increased tumour aggressiveness in prostate cancer and might be a promising target for therapeutical interventions in primary and metastatic prostate cancer.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cell Adhesion Molecules / analysis. Prostatic Neoplasms / chemistry
  • [MeSH-minor] Aged. Chi-Square Distribution. Cohort Studies. Epithelial Cells / chemistry. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Prognosis. Prostate-Specific Antigen / analysis. Stromal Cells / chemistry. Time Factors. Up-Regulation

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  • (PMID = 20534149.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Adhesion Molecules; 0 / POSTN protein, human; EC 3.4.21.77 / Prostate-Specific Antigen
  • [Other-IDs] NLM/ PMC2903527
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31. Jonathan A, Rajshekhar V, Chacko G: Chondromyxoid fibroma of the seventh cervical vertebra. Neurol India; 2008 Jan-Mar;56(1):84-7
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  • Chondromyxoid fibroma is a rare benign bone tumor representing less than 0.5% of all bone tumors.
  • A presumptive diagnosis of a bony tumor such as an aneurysmal bone cyst or a giant cell tumor involving the seventh vertebral body was made on plain X-rays, MRI and bone scan.
  • He underwent C7 central corpectomy, incomplete intralesional curettage with iliac bone grafting and C6 to T1 interspinous wiring.
  • The histological diagnosis was chondromyxoid fibroma.
  • On eight years' follow-up, CT scan showed no progression of the tumor with good alignment and fusion of the graft at the site of the corpectomy.
  • The authors conclude that corpectomy and iliac bone grafting for chondromyxoid fibroma has a good outcome on long-term follow-up.
  • [MeSH-major] Bone Neoplasms / complications. Bone Neoplasms / pathology. Cervical Vertebrae / pathology. Chondromatosis / complications. Fibroma / complications. Fibroma / pathology

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  • (PMID = 18310848.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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32. Boriani S, Bandiera S, Donthineni R, Amendola L, Cappuccio M, De Iure F, Gasbarrini A: Morbidity of en bloc resections in the spine. Eur Spine J; 2010 Feb;19(2):231-41
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  • The morbidity of surgical procedures for spine tumors can be expected to be worse than for other conditions.
  • A retrospective study of 1,035 patients affected by spine tumors-treated from 1990 to 2007 by the same team-identified 134 patients (53.0% males, age 44 +/- 18 years) who had undergone en bloc resection for primary tumors (90) and bone metastases (44).
  • The study was set up to correlate diagnosis, staging and treatment with the outcome.
  • Oncological and functional results were recorded for all patients at periodic, diagnosis-related controls, until death or the latest follow-up examination (from 0 to 211 months, median 47 months, 25th-75th percentile 22-85 months).
  • Of the 35 patients with a recurrent or contaminated tumor, 16 (45.7%) suffered at least one complication; by contrast, complications arose in 31 (31.3%) of the 99 patients who had had no previous treatment and who underwent the whole of their treatment in the same center (P = 0.125).
  • Re-operations were mostly due to tumor recurrences, but also to hardware failures, wound dehiscence, hematomas and aortic dissection.
  • En bloc resection is able to improve the prognosis of aggressive benign and low-grade malignant tumors in the spine; however, complications are not rare and possibly fatal.
  • [MeSH-minor] Adult. Aged. Aortic Rupture / mortality. Equipment Failure. Female. Humans. Male. Middle Aged. Mortality. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Outcome Assessment (Health Care). Radiotherapy / adverse effects. Reoperation / mortality. Retrospective Studies. Surgical Wound Dehiscence / mortality. Surgical Wound Infection / mortality. Treatment Outcome

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  • (PMID = 19690899.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2899819
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33. Fukunaga S, Futani H, Yoshiya S: Endoscopically assisted resection of a scapular osteochondroma causing snapping scapula syndrome. World J Surg Oncol; 2007;5:37
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  • BACKGROUND: Osteochondroma is the most common benign bone tumor in the scapula.
  • Removal of the tumor was performed by the use of endoscopically assisted resection.
  • The tumor was resected in a piece-by-piece manner by the use of graspers through the same portal.
  • CT images showed complete tumor resection.
  • [MeSH-major] Bone Neoplasms / surgery. Endoscopy. Osteochondroma / surgery. Scapula

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  • (PMID = 17378939.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1839090
  • [General-notes] NLM/ Original DateCompleted: 20070726
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34. Bostan B, Sen C, Gunes T, Erdem M, Koseoglu RD: Osteoid osteoma of the trapezium: case report. J Hand Surg Am; 2010 Apr;35(4):636-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoid osteoma is a benign bone tumor representing approximately 10% of all benign bone tumors.
  • [MeSH-major] Bone Neoplasms / diagnosis. Osteoma, Osteoid / diagnosis. Trapezium Bone / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Diagnostic Imaging. Humans. Male

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  • (PMID = 20171814.001).
  • [ISSN] 1531-6564
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Mir NA, Baba AN, Maajid S, Badoo AR, Mir GR: Osteoblastoma of body of the talus--Report of a rare case with atypical radiological features. Foot Ankle Surg; 2010 Jun;16(2):e24-6
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  • Osteoblastoma is a benign bone tumour found commonly in the spine and long tubular bones.
  • Analysis of clinical, radiological and histological findings confirmed the diagnosis of osteoblastoma.
  • [MeSH-major] Bone Neoplasms / radiography. Osteoblastoma / radiography. Rare Diseases. Talus. Tomography, X-Ray Computed
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Osteotomy / methods

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  • [Copyright] Copyright 2009 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20483122.001).
  • [ISSN] 1460-9584
  • [Journal-full-title] Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons
  • [ISO-abbreviation] Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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36. Theumann N, Hauser P, Schmidt S, Schnyder P, Leyvraz PF, Mouhsine E: [Osteoid osteoma and radiofrequency]. Rev Med Suisse; 2005 Dec 21;1(46):2989-94
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  • [Transliterated title] Thermoablation par radiofréquence de l'ostéome ostéoïde.
  • Osteoid osteoma and radiofrequency Osteoid osteoma relates to a benign skeletal neoplasm, smaller than 2 cm in diameter, composed of osteoid, highly vascularized connective tissue and surrounded by a ring of bone sclerosis.
  • [MeSH-major] Bone Neoplasms / surgery. Catheter Ablation / methods. Osteoma, Osteoid / surgery

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  • (PMID = 16429972.001).
  • [ISSN] 1660-9379
  • [Journal-full-title] Revue médicale suisse
  • [ISO-abbreviation] Rev Med Suisse
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Salicylates
  • [Number-of-references] 12
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37. Murphey MD: World Health Organization classification of bone and soft tissue tumors: modifications and implications for radiologists. Semin Musculoskelet Radiol; 2007 Sep;11(3):201-14
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  • [Title] World Health Organization classification of bone and soft tissue tumors: modifications and implications for radiologists.
  • The working group of the World Health Organization (WHO) for classification of tumors of soft tissue and bone met in 2002.
  • The consensus of this conference led to modifications in the nomenclature primarily for soft tissue neoplasm, leaving osseous tumors largely unaltered.
  • This allows improved uniformity in our discussions with pathologists and orthopedic oncologists in our team approach in the diagnosis and treatment of these patients.
  • [MeSH-major] Bone Neoplasms / classification. Diagnostic Imaging. Soft Tissue Neoplasms / classification. World Health Organization
  • [MeSH-minor] Fibrosarcoma / classification. Histiocytoma, Benign Fibrous / classification. Humans. Liposarcoma / classification. Terminology as Topic


38. Jundt G, Baumhoer D: [Hereditary bone tumors]. Pathologe; 2010 Oct;31(6):471-6
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  • [Title] [Hereditary bone tumors].
  • Familial diseases leading to bone tumor formation are rare.
  • This leads to multiple benign bone tumors, which may undergo secondary malignant transformation (enchondromatosis: enchondromas, multiple hereditary exostoses: osteochondromas) or bone sarcomas, mainly osteosarcomas, such as primary (Li-Fraumeni, Rothmund-Thomson, Werner and Bloom syndromes) or secondary manifestations (retinoblastoma syndrome) of the underlying disease.
  • In contrast to sporadically occurring similar tumors, differences in manifestation in time, topography or histology may be present which can aid in the correct recognition of the underlying syndrome.
  • [MeSH-major] Bone Neoplasms / genetics

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  • (PMID = 20960198.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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39. Dierselhuis EF, Jutte PC, van der Eerden PJ, Suurmeijer AJ, Bulstra SK: Hip fracture after radiofrequency ablation therapy for bone tumors: two case reports. Skeletal Radiol; 2010 Nov;39(11):1139-43
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  • [Title] Hip fracture after radiofrequency ablation therapy for bone tumors: two case reports.
  • In orthopedic surgery, RFA is used for the treatment of benign bone tumors and bone metastases.
  • Complications are rare and, to our knowledge, bone fracture as a complication due solely to RFA has not been reported to date.
  • In this report we describe two patients with a fracture in the calcar region of the femur as a complication of RFA treatment for bone malignancies.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Catheter Ablation / adverse effects. Femoral Fractures / diagnosis. Femoral Fractures / etiology. Magnetic Resonance Imaging. Tomography, X-Ray Computed


40. Matsubayashi S, Nakashima M, Kumagai K, Egashira M, Naruke Y, Kondo H, Hayashi T, Shindo H: Immunohistochemical analyses of beta-catenin and cyclin D1 expression in giant cell tumor of bone (GCTB): a possible role of Wnt pathway in GCTB tumorigenesis. Pathol Res Pract; 2009;205(9):626-33
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  • [Title] Immunohistochemical analyses of beta-catenin and cyclin D1 expression in giant cell tumor of bone (GCTB): a possible role of Wnt pathway in GCTB tumorigenesis.
  • Giant cell tumor of bone (GCTB) is a benign neoplasm but occasionally shows local recurrence, and histologically consists of osteoclast-like giant cells (GC) and stromal mononuclear cells (SC), which are capable of proliferation and osteoblastic differentiation.
  • Activation of Wnt signaling can induce osteoblast differentiation and osteoclastgenesis during bone resorption process.
  • We performed immunohistochemistry for beta-catenin, cyclin D1, and Ki-67 in 16 GCTB tumors, including 5 recurrent cases that were surgically resected.
  • The nuclear beta-catenin labeling index (LI) in both SC (60.6 vs. 41.8%, p=0.074) and GC (41.7 vs. 20.1%, p=0.095) was higher in recurrent tumors than in primary tumors in all the 4 cases.
  • However, Ki-67 LI in SC (18.8 vs. 19.9%, p=0.851) and cyclin D1 LI in GC (55.4 vs. 70.1%, p=0.225) were not higher in recurrent tumors than in primary tumors.
  • Importantly, it was suggested that the nuclear beta-catenin staining level might be associated with tumor recurrence in GCTB.
  • [MeSH-major] Bone Neoplasms / metabolism. Cyclin D1 / biosynthesis. Giant Cell Tumor of Bone / metabolism. Wnt Proteins / metabolism. beta Catenin / biosynthesis
  • [MeSH-minor] Adolescent. Adult. Cell Nucleus / metabolism. Female. Gene Expression. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Ki-67 Antigen / biosynthesis. Ki-67 Antigen / genetics. Male. Middle Aged. Neoplasm Recurrence, Local / metabolism. Signal Transduction / physiology. Young Adult

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  • (PMID = 19324500.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Wnt Proteins; 0 / beta Catenin; 136601-57-5 / Cyclin D1
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41. Li J, Wang ZQ, Zhang YM, Song HP, Yuan L: [Application of allogeneic bone in surgical treatment of benign bone neoplasm]. Nan Fang Yi Ke Da Xue Xue Bao; 2006 Jul;26(7):987-90
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  • [Title] [Application of allogeneic bone in surgical treatment of benign bone neoplasm].
  • OBJECTIVE: To evaluate the clinical outcomes of allogeneic bone grafting for bone defect resulting from benign neoplasm resection and discuss the clinical application and bone defect repair mechanisms of allogeneic bone.
  • METHODS: A retrospective review was conducted of 135 patients with benign neoplasm resection who received bone defect filling with the allogeneic bone graft.
  • RESULTS: In the 104 patients with complete clinical follow-up data, 96 achieved bone union, 7 experienced relapses to require surgical intervention and 1 had severe infection to lead to failure of the operation.
  • The mean time for bone union was 9.7 months, and during the follow-up, no viral disease in relation to the graft was found after surgery.
  • CONCLUSION: Bone defect filling with allogeneic bone graft can be simple and safe in comparison with that with autograft or other biomaterials, and the bone healing time, infection rate and local tumor recurrence can be comparable with the autograft.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / methods

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  • (PMID = 16864094.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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42. Mackenzie H, Gulati V, Tross S: A rare case of a swollen knee due to disseminated synovial chondromatosis: a case report. J Med Case Rep; 2010;4:113
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  • INTRODUCTION: A synovial chondromatosis is a rare benign neoplasm on the synovium.
  • Although described as a benign disease, it can be very destructive and can cause severe osteoarthritis and pain.
  • CONCLUSIONS: Although synovial chondromatosis is described as a benign disease, it can be very destructive and debilitating.

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  • [Cites] J Arthroplasty. 2008 Apr;23(3):395-400 [18358378.001]
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  • (PMID = 20416049.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2873448
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43. Darby S, Cross SS, Brown NJ, Hamdy FC, Robson CN: BMP-6 over-expression in prostate cancer is associated with increased Id-1 protein and a more invasive phenotype. J Pathol; 2008 Feb;214(3):394-404
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  • Bone morphogenetic protein-6 (BMP-6) has been strongly implicated in prostate cancer development and bone metastasis.
  • Our previous data showed that BMP-6 mRNA was absent in patients with benign prostatic hyperplasia, but evident in primary tumours with established secondary skeletal metastases.
  • We observed a significant increase in the intensity of staining of epithelial BMP-6 in the cancer cases compared to the benign cases (Mann-Whitney U test, p < 0.0005) and in the intensity of staining of epithelial Id-1 in the cancer cases compared to the benign cases (Mann-Whitney U test, p = 0.015).
  • We further observed a significant positive correlation between epithelial staining for Id-1 and BMP-6 (p = 0.001) across all samples for both benign and cancer cases.
  • [MeSH-major] Biomarkers, Tumor. Bone Morphogenetic Proteins / genetics. Gene Expression Regulation, Neoplastic. Inhibitor of Differentiation Protein 1 / genetics. Prostatic Neoplasms / metabolism
  • [MeSH-minor] Bone Morphogenetic Protein 6. Case-Control Studies. Cell Line, Tumor. Doxycycline / pharmacology. Gene Expression Profiling. Humans. Immunohistochemistry. Male. Matrix Metalloproteinase 1 / genetics. Matrix Metalloproteinase 9 / genetics. Neoplasm Invasiveness. Oligonucleotide Array Sequence Analysis. Phenotype. Prostate / metabolism. RNA, Messenger / analysis. Smad1 Protein / genetics. Statistics, Nonparametric. Transfection / methods

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  • [Copyright] Copyright (c) 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
  • (PMID = 18072288.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0500966
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / BMP6 protein, human; 0 / Biomarkers, Tumor; 0 / Bone Morphogenetic Protein 6; 0 / Bone Morphogenetic Proteins; 0 / ID1 protein, human; 0 / Inhibitor of Differentiation Protein 1; 0 / RNA, Messenger; 0 / Smad1 Protein; EC 3.4.24.35 / Matrix Metalloproteinase 9; EC 3.4.24.7 / Matrix Metalloproteinase 1; N12000U13O / Doxycycline
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44. Angiero F, Mellone P, Baldi A, Stefani M: Osteoblastoma of the jaw: report of two cases and review of the literature. In Vivo; 2006 Sep-Oct;20(5):665-70
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  • Osteoblastoma is a benign bone tumor of osteoblastic origin.
  • Both tumors were resected with wide surgical margins and neither patient had adjuvant radiation or chemotherapy.
  • Differential diagnosis and immunohistochemical features potentially useful for refining diagnosis of osteoblastoma are also discussed.
  • [MeSH-major] Biomarkers, Tumor / analysis. Jaw Neoplasms / pathology. Osteoblastoma / pathology

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  • (PMID = 17091775.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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45. Gaeta M, Mazziotti S, Minutoli F, Genitori A, Toscano A, Rodolico C, Blandino A: MR imaging findings of focal myositis: a pseudotumour that may mimic muscle neoplasm. Skeletal Radiol; 2009 Jun;38(6):571-8
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  • [Title] MR imaging findings of focal myositis: a pseudotumour that may mimic muscle neoplasm.
  • Dynamic enhancement pattern corresponded to the type usually seen in benign soft tissue lesions.
  • CONCLUSION: Focal myositis is an uncommon pseudotumour which should be considered in the differential diagnosis of muscular masses and myopathies.
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Young Adult

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  • (PMID = 19255757.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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46. Fritsche-Guenther R, Gruetzkau A, Noske A, Melcher I, Schaser KD, Schlag PM, Kasper HU, Krenn V, Sers C: Therapeutic potential of CAMPATH-1H in skeletal tumours. Histopathology; 2010 Dec;57(6):851-61
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  • [Title] Therapeutic potential of CAMPATH-1H in skeletal tumours.
  • The aim of this study was to analyse tissue and cell lines of non-neoplastic bone, cartilage and skeletal tumours for CD52 expression.
  • Malignant tumours showed higher CD52 expression compared to benign tumours, suggesting a role in the development and progression of bone tumours.
  • Interestingly, immunohistochemistry and flow cytometry revealed that CD52 was expressed not only on the surface of tumour cells, but also in the cytoplasm.
  • CONCLUSION: CD52 is expressed in a variety of bone tumours and the in vitro studies presented herein suggest that CAMPATH-1H treatment might have therapeutic potential for osteosarcoma patients.
  • [MeSH-major] Antibodies, Monoclonal / pharmacology. Antibodies, Neoplasm / pharmacology. Antigens, CD / immunology. Antigens, Neoplasm / immunology. Antineoplastic Agents / pharmacology. Bone Neoplasms / immunology. Bone and Bones / immunology. Chondroma / immunology. Glycoproteins / immunology. Sarcoma / immunology

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  • [Copyright] © 2010 Blackwell Publishing Limited.
  • (PMID = 21166699.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antibodies, Neoplasm; 0 / Antigens, CD; 0 / Antigens, Neoplasm; 0 / Antineoplastic Agents; 0 / CD52 antigen; 0 / Glycoproteins; 3A189DH42V / alemtuzumab
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47. Poffyn B, Sys G, Van Maele G, Van Hoorebeke L, Forsyth R, Verstraete K, Uyttendaele D: Radiographic analysis of extracorporeally irradiated autografts. Skeletal Radiol; 2010 Oct;39(10):999-1008
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  • OBJECTIVE: To analyse the long-term radiographic findings of intercalary, pure osteoarticular, and composite bone grafts in patients with primary bone sarcoma who were treated by reimplantation of the bone as an orthotopic autograft.
  • MATERIALS AND METHODS: For this observational clinical study, 107 patients who presented with 108 malignant or locally aggressive benign bone tumours were treated by resection, extracorporeal irradiation (300 Gy), and reimplantation and fixation of the autograft.
  • Bone healing features were evaluated with the International Society of Limb Salvage (ISOLS) graft evaluation method, which assesses fusion, resorption, fracture, graft shortening, fixation, subluxation, joint narrowing, and subchondral bone.
  • CONCLUSION: This reconstruction technique is valid for the three methods described; bone stock is retained and, once the graft has healed, it behaves as normal bone.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / diagnostic imaging. Bone Transplantation / methods. Sarcoma / surgery

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  • (PMID = 20703876.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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48. Mangal N, Sharma VK, Verma N, Agarwal AK, Sharma SP, Aneja S: Ultrasound guided fine needle aspiration cytology in the diagnosis of retroperitoneal masses: A study of 85 cases. J Cytol; 2009 Jul;26(3):97-101
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  • [Title] Ultrasound guided fine needle aspiration cytology in the diagnosis of retroperitoneal masses: A study of 85 cases.
  • BACKGROUND: The diagnosis of retroperitoneal lesions is one of the most difficult areas in surgical pathology.
  • The retroperitoneal space allows both primary and metastatic tumors to grow silently before the appearance of clinical signs and symptoms.
  • Fine needle aspiration cytology has shown promising role in establishing the diagnosis in this region.
  • OBJECTIVES: This study was undertaken to evaluate the reliability of ultrasonography (USG)-guided fine needle aspiration cytology (FNAC) in distinguishing between benign and malignant lesions in the retroperitoneum, and to correlate the diagnosis by cytology of retroperitoneal masses with the results obtained by histology.
  • In the kidney, the maximum number of cases were of renal cell carcinoma (12-38%), followed by Wilm's tumor (6-19%), pyonephrosis (5-16%), renal cyst (4), angiomyolipoma (2), cortical pseudotumor (2), and tuberculosis (1).
  • Among the 24 soft tissue tumors in the study, seven (29%) were malignant and 17 (71%) were benign (lipoma being the most common benign neoplasm).
  • CONCLUSIONS: USG-guided FNAC is an inexpensive, rapid, safe, and accurate procedure for the diagnosis of retroperitoneal masses.

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  • [Cites] Acta Cytol. 1993 Jul-Aug;37(4):477-82 [8392251.001]
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  • [Cites] Indian J Pathol Microbiol. 1992 Oct;35(4):333-9 [1344223.001]
  • (PMID = 21938165.001).
  • [ISSN] 0970-9371
  • [Journal-full-title] Journal of cytology
  • [ISO-abbreviation] J Cytol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3168018
  • [Keywords] NOTNLM ; Ultrasound / fine needle aspiration cytology / retroperitoneum
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49. Gupta SP, Agarwal A: Intraosseous neurilemmoma of L2 vertebra--a case report. Indian J Pathol Microbiol; 2005 Jul;48(3):367-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Intraosseous neurilemmoma (schwannoma) is a rare bone tumor with incidence less than 0.2% of all primary bone tumors.
  • It is a benign neoplasm arising from the schwann cells of the nerve sheath.
  • Computed tomograph revealed a large soft tissue component of the tumor mass with thecal sac compression.
  • A computed tomograph assisted needle biopsy revealed the tumor to be neurilemmoma.
  • Subsequently, during decompression, it was possible to shell out tumor from surrounding tissues.
  • Remaining tumor was curettedfrom bone and the cavity packed with autograft.
  • The aim of this article is to highlight intraosseous neurilemmoma as a possible differential diagnosis in bony tumors.

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  • (PMID = 16761755.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 4
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50. Ortakoglu K, Akcam T, Sencimen M, Karakoc O, Ozyigit HA, Bengi O: Osteochondroma of the mandible causing severe facial asymmetry: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 May;103(5):e21-8
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  • Osteochondroma is one of the most common benign tumors of bone.
  • The aim of the present study is to emphasize the importance of stereolithographic models in planning tumor surgery and how it affects the treatment planning, operation time and prognosis.
  • Based on the model evaluation, the tumor was conservatively resected and the condyle left intact, leaving no sequelae.

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  • (PMID = 17331758.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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51. Sierre S, Innocenti S, Lipsich J, Lanfranchi L, Questa H, Moguillansky S: Percutaneous treatment of osteoid osteoma by CT-guided drilling resection in pediatric patients. Pediatr Radiol; 2006 Feb;36(2):115-8
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  • BACKGROUND: Osteoid osteoma is a painful, benign, small osteogenic bone tumor.
  • [MeSH-major] Bone Neoplasms / diagnostic imaging. Bone Neoplasms / surgery. Osteoma, Osteoid / diagnostic imaging. Osteoma, Osteoid / surgery. Osteotomy. Tomography, X-Ray Computed
  • [MeSH-minor] Adolescent. Child. Female. Humans. Male. Minimally Invasive Surgical Procedures / methods. Neoplasm Recurrence, Local. Reoperation. Retrospective Studies. Treatment Outcome

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  • [Cites] Radiology. 1997 Jun;203(3):843-8 [9169714.001]
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  • (PMID = 16315060.001).
  • [ISSN] 0301-0449
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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52. Lin SP, Fang YC, Chu DC, Chang YC, Hsu CI: Characteristics of cranial aneurysmal bone cyst on computed tomography and magnetic resonance imaging. J Formos Med Assoc; 2007 Mar;106(3):255-9
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  • [Title] Characteristics of cranial aneurysmal bone cyst on computed tomography and magnetic resonance imaging.
  • Aneurysmal bone cysts are benign bone tumors that most commonly occur in people younger than 30 years.
  • The tumor was soft, fragile, and pulsatile during surgery.
  • The patient was treated with en bloc resection of the tumor with cranioplasty.

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  • (PMID = 17389172.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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53. Fu K, Meng ZB, Li J, Li HC: [Repairing the defect of benign bone tumor with the coralline hydroxyapatite]. Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2008 May;33(5):421-4
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  • [Title] [Repairing the defect of benign bone tumor with the coralline hydroxyapatite].
  • OBJECTIVE: To observe the clinical effect of repairing bone defectin post-operation benign tumor with coralline hydroxyapatite(CHAP).
  • The CHAP was implanted into the lesion after bone tumor curettage to 25 patients.
  • The sizes of bone defect ranged from 0.8 cm x 0.5 cm x 0.5 cm to 10 cm x 3.5 cm x 2 cm.
  • X-ray showed that there was osteogenesis at the cortical bone 1 month post-operation.
  • There is corresponding synchronization between bone formation with CHAP biodegradation.
  • The CHAP is an excellent bone defect repairing material.
  • [MeSH-major] Bone Neoplasms / surgery. Ceramics. Giant Cell Tumor of Bone / surgery. Hydroxyapatites. Prostheses and Implants
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Cysts / surgery. Bone Regeneration. Bone Substitutes. Child. Female. Femur / surgery. Humans. Male. Middle Aged

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  • (PMID = 18544846.001).
  • [ISSN] 1672-7347
  • [Journal-full-title] Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
  • [ISO-abbreviation] Zhong Nan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Bone Substitutes; 0 / Hydroxyapatites; 0 / coralline hydroxyapatite
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54. Brochard C, Michalak S, Aubé C, Singeorzan C, Fournier HD, Laccourreye L, Calès P, Boursier J: A not so solitary fibrous tumor of the liver. Gastroenterol Clin Biol; 2010 Dec;34(12):716-20
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  • [Title] A not so solitary fibrous tumor of the liver.
  • Solitary fibrous tumor (SFT) is a rare neoplasm.
  • Liver parenchyma is a rare location of SFT and, in this case, it usually follows a benign course.
  • We report here the case of a 54-year-old man who presented a large SFT tumor of the right hepatic lobe.
  • The tumor was surgically resected.
  • Local recurrence occurred 6 years later as a 15 cm diameter liver tumor.
  • Two years later, the patient presented with complaints of neck pain and ensuing examinations revealed a tumor of the cranial base.
  • Few weeks later, the patient presented an irreducible psoitis due to an iliac bone metastasis.
  • [MeSH-major] Liver Neoplasms / pathology. Skull Base Neoplasms / secondary. Solitary Fibrous Tumors / secondary

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20864281.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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55. Saw S, Thomas N, Gleeson MJ, Bódi I, Connor S, Hortobágyi T: Giant cell tumour and central giant cell reparative granuloma of the skull: do these represent ends of a spectrum? A case report and literature review. Pathol Oncol Res; 2009 Jun;15(2):291-5
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  • [Title] Giant cell tumour and central giant cell reparative granuloma of the skull: do these represent ends of a spectrum? A case report and literature review.
  • Giant cell tumour (GCT) of bone is an uncommon primary bone neoplasm typically occurring at the epiphyses of long bones in young adults.
  • These tumours appear very rarely in the skull, with those few reported cases arising predominantly in the sphenoid and occasionally the temporal bones.
  • They demonstrate benign histological features, but are locally aggressive and surgical excision is the treatment of choice.
  • It is widely believed that giant cell tumours should be distinguished from other giant cell lesions, importantly central giant cell reparative granulomata (CGCG) which are thought to have a lower recurrence rate and for which no cases of malignant transformation or metastases have been reported.
  • We present a case of a giant cell tumour of the temporal bone which illustrates and re-emphasises this concept and review the literature on these lesions.
  • [MeSH-major] Giant Cell Tumors / pathology. Granuloma, Giant Cell / pathology. Skull Neoplasms / pathology

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  • [Cites] Cancer. 1992 Oct 1;70(7):1886-94 [1525763.001]
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  • (PMID = 19011995.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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56. Matsuo T, Hiyama E, Sugita T, Shimose S, Kubo T, Mochizuki Y, Adachi N, Kojima K, Sharman P, Ochi M: Telomerase activity in giant cell tumors of bone. Ann Surg Oncol; 2007 Oct;14(10):2896-902
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Telomerase activity in giant cell tumors of bone.
  • BACKGROUND: A giant cell tumor of bone (GCT) is a histologically benign neoplasma that has an unpredictable pattern of biological aggressiveness.
  • The telomere lengths of tumors were significantly shorter than those of normal tissue (P = .008).
  • The mean telomere length of grade 3 tumors was significantly shorter than those of grade 1 and 2 tumors (P = .038).
  • Telomerase activity was detected in 81% of tumor samples.
  • The level of telomerase activity in tumors with local recurrence was significantly higher than in tumors without local recurrence (P = .011).
  • [MeSH-major] Bone Neoplasms / genetics. Giant Cell Tumor of Bone / genetics. Telomerase / genetics
  • [MeSH-minor] Adolescent. Adult. Blotting, Southern. Bone and Bones / pathology. Bone and Bones / surgery. Extremities / surgery. Female. Femoral Neoplasms / genetics. Femoral Neoplasms / pathology. Femoral Neoplasms / surgery. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / genetics. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Polymerase Chain Reaction. Polymorphism, Restriction Fragment Length / genetics. Prognosis

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  • (PMID = 17653593.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
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57. Idan A, Griffiths KA, Harwood DT, Seibel MJ, Turner L, Conway AJ, Handelsman DJ: Long-term effects of dihydrotestosterone treatment on prostate growth in healthy, middle-aged men without prostate disease: a randomized, placebo-controlled trial. Ann Intern Med; 2010 Nov 16;153(10):621-32
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  • BACKGROUND: Benign prostatic hypertrophy increases with age and can result in substantially decreased quality of life for older men.
  • MEASUREMENTS: Prostate volume was measured by ultrasonography; bone mineral density (BMD) and body composition were measured by dual-energy x-ray absorptiometry; and blood samples and questionnaires were collected every 6 months, with data analyzed by mixed-model analysis for repeated measures.
  • [MeSH-minor] Administration, Cutaneous. Antigens, Neoplasm / blood. Body Composition / drug effects. Bone Density / drug effects. Collagen Type I / blood. Double-Blind Method. Estradiol / blood. Fetal Proteins. Gels. Humans. Luteinizing Hormone / blood. Male. Middle Aged. Peptide Fragments. Procollagen. Prostate-Specific Antigen / blood. Prostatic Hyperplasia / prevention & control. Testosterone / blood

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  • [CommentIn] Ann Intern Med. 2010 Nov 16;153(10):678-9 [21079226.001]
  • [CommentIn] Praxis (Bern 1994). 2011 Mar 2;100(5):319-20 [21365566.001]
  • [SummaryForPatientsIn] Ann Intern Med. 2010 Nov 16;153(10):I38 [21079202.001]
  • (PMID = 21079217.001).
  • [ISSN] 1539-3704
  • [Journal-full-title] Annals of internal medicine
  • [ISO-abbreviation] Ann. Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Androgens; 0 / Antigens, Neoplasm; 0 / Collagen Type I; 0 / Fetal Proteins; 0 / Gels; 0 / Peptide Fragments; 0 / Procollagen; 0 / procollagen Type I N-terminal peptide; 08J2K08A3Y / Dihydrotestosterone; 3XMK78S47O / Testosterone; 4TI98Z838E / Estradiol; 9002-67-9 / Luteinizing Hormone; EC 3.4.21.77 / Prostate-Specific Antigen
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58. Guo Z, Wang Z, Li J, Li XD: [Reconstruction with a new type of combined reconstruction following excision of periacetabular tumors]. Zhonghua Wai Ke Za Zhi; 2008 Jun 15;46(12):895-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Reconstruction with a new type of combined reconstruction following excision of periacetabular tumors].
  • OBJECTIVE: To evaluate the reconstructive effect of a new pattern of combined reconstruction after periacetabular tumor resections.
  • METHODS: Between March 2001 and March 2007, tumor resections and new pattern of combined reconstructions which consisted of screw-rod system, acetabular reinforcement shell, antibiotic cement and total hip arthroplasty techniques were performed in 23 patients with periacetabular tumors.
  • Seventeen patients had primary malignant tumors including 7 chondrosarcomas, 4 osteosarcomas, 2 Ewing sarcomas, 2 malignant fibrohistiocytomas, 1 malignant Schwannomas, and 1 synovial sarcoma.
  • Other primary tumors were 2 giant cell tumors and 1 aggressive osteoblastoma.
  • Three metastatic bone tumors were also included in this study, and the original sites were thyroid, breast, and ovary.
  • Three primary benign bone tumors belonged to stage III.
  • 8 months (range, 9-73 months) in the patients with primary tumors.
  • CONCLUSIONS: This new combined reconstruction is an effective way to rebuild pelvic ring and maintain hip function with low complication rate after periacetabular tumor resections.
  • [MeSH-major] Acetabulum. Bone Neoplasms / surgery. Reconstructive Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Arthroplasty, Replacement, Hip. Bone Screws. Female. Follow-Up Studies. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 19035146.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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59. Rougraff BT: Bone graft alternatives in the treatment of benign bone tumors. Instr Course Lect; 2005;54:505-12
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  • [Title] Bone graft alternatives in the treatment of benign bone tumors.
  • Most bone grafting procedures are done during spinal fusion and to treat patients with skeletal trauma.
  • Very few studies have addressed the bone grafting of skeletal defects after benign bone tumor excision.
  • Contained defects have been treated with autogenous bone grafts, fresh-frozen allografts, freeze-dried allografts, demineralized bone matrix, and ceramic materials.
  • Additionally, bone morphogenetic proteins may provide a future treatment option for bone tumor reconstruction.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / methods
  • [MeSH-minor] Bone Substitutes. Ceramics. Humans. Tissue Preservation / methods. Transplantation, Homologous

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  • (PMID = 15948475.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Substitutes
  • [Number-of-references] 30
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60. Park YK, Kim EJ, Kim SW: Osteoblastoma of the ethmoid sinus. Skeletal Radiol; 2007 May;36(5):463-7
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  • An osteoblastoma is a benign bone tumor that most often occurs in the vertebral column and the long bones of the extremities.
  • A mixture of ground glass opacity and dense bone was present.
  • Histologically, the lesion was composed of proliferating osteoblasts along with small trabeculae of woven bone and rich vascular fibrous stroma.
  • [MeSH-major] Ethmoid Sinus / pathology. Ethmoid Sinus / surgery. Osteoblastoma / diagnosis. Osteoblastoma / surgery. Paranasal Sinus Neoplasms / diagnosis. Paranasal Sinus Neoplasms / surgery

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  • (PMID = 17265159.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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61. Liang X, Jiang D, Ni W: [Clinical observation on nano-hydroxyapatite and polyamide 66 composite in repairing bone defect due to benign bone tumor]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2007 Aug;21(8):785-8
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  • [Title] [Clinical observation on nano-hydroxyapatite and polyamide 66 composite in repairing bone defect due to benign bone tumor].
  • OBJECTIVE: To observe the clinical effect and safety of the nano-hydroxyapatite/polyamide 66 (n-HA/PA66) composite in repairing the bone defects due to benign bone tumors.
  • METHODS: From January 2003 to May 2005, 38 patients (21 males, 16 females; age, 19-58 years, averaged 38.5 years) with the bone defects due to benign bone tumors were treated with the n-HA/PA66 grains.
  • Among the 37 patients, 11 had fibrous dysplasia, 14 had bone cyst, 10 had giant cell tumor of the bone (Grade I ), and 2 had enchondroma.
  • The tumors ranged in size from 1.0 cm x 0.7 cm x 0.4 cm to 10.0 cm x 4.0 cm x 3.0 cm, with the location of the proximal femur in 12 patients, the distal femur in 7, the proximal tibia in 9, the proximal humerus in 5, the phalanges of the finger in 2, the metacarpal bone in 1, and the calcaneus in 1.
  • All the benign bone tumors underwent the curettage treatment, and then the tumor cavities were filled up with the n-HA/PA66 grains.
  • The incision healing, local inflammatory reaction, rejection, toxic reaction, tumor cavity healing, and function recovery of the limbs were all observed after operation.
  • CONCLUSION: The n-HA/PA66 grains have great biological safety, good biocompatibility, and good bone conduction, which are good materials for the bone repair and reconstruction, and can be safely, and effectively used for repairing the bone defects due to benign bone tumors.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Substitutes. Hydroxyapatites. Nylons
  • [MeSH-minor] Adult. Biocompatible Materials. Bone Cysts / surgery. Female. Follow-Up Studies. Giant Cell Tumor of Bone / surgery. Humans. Male. Middle Aged. Nanostructures. Reconstructive Surgical Procedures / methods. Treatment Outcome. Wound Healing. Young Adult

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  • (PMID = 17882867.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Bone Substitutes; 0 / Hydroxyapatites; 0 / Nylons
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62. Roy S, Dobson P, Henry L: An isolated osteochondroma with underlying non-Hodgkin's lymphoma of bone. J Bone Joint Surg Br; 2005 Oct;87(10):1423-4
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  • [Title] An isolated osteochondroma with underlying non-Hodgkin's lymphoma of bone.
  • Osteochondroma is the most common benign bone tumour.
  • We report a case of an isolated osteochondroma which appeared benign on clinical and plain radiographic examination but routine histological analysis revealed non-Hodgkin's lymphoma in the underlying bone.
  • This association has not previously been reported and the case emphasises the importance of routine histological analysis, even if a lesion appears benign.
  • [MeSH-major] Bone Neoplasms / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Neoplasms, Multiple Primary / pathology. Osteochondroma / pathology

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  • (PMID = 16189321.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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63. Abolghasemian M, Rezaie M, Behgoo A, Shoushtarizadeh T, Ghazavi MT: Exostosis-like intra-articular periosteal osteoblastoma: a rare case. Am J Orthop (Belle Mead NJ); 2010 Jun;39(6):E50-3
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  • Osteoblastoma is a relatively rare benign bone tumor, most often located in the vertebral column or metaphysis of the long bones, particularly the femur and the tibia.
  • Exostosis-like appearance is not common even in periosteal osteoblastoma, a very rare type of this tumor.
  • [MeSH-major] Bone Neoplasms / pathology. Hip Joint / pathology. Osteoblastoma / pathology. Periosteum / pathology

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  • (PMID = 20631934.001).
  • [ISSN] 1934-3418
  • [Journal-full-title] American journal of orthopedics (Belle Mead, N.J.)
  • [ISO-abbreviation] Am J. Orthop.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Blackwell JB, Curnow MN: Benign bone tumours in Western Australia, 1972-1996. Pathology; 2007 Dec;39(6):567-74
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  • [Title] Benign bone tumours in Western Australia, 1972-1996.
  • AIMS: To review the benign bone tumours accessioned by the Bone Tumour Registry (BTR) of Western Australia (WA) during the years 1972-1996 and to determine the incidence of the more common types.
  • RESULTS: During the 25 year period, 849 benign tumours were accessioned and incidence rates have been calculated for 86 chondromas, 68 osteoid osteomas, 47 giant cell tumours, 32 chondroblastomas, 15 periosteal chondromas and 13 chondromyxoid fibromas.
  • CONCLUSION: The BTR provides a valuable resource for the study of primary bone tumours.
  • This review has established reliable incidence rates for the six most common benign tumours.
  • Such information is rarely available for benign tumours.
  • [MeSH-major] Bone Neoplasms / pathology. Registries
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Infant. Male. Middle Aged. Neoplasm Recurrence, Local. Western Australia / epidemiology

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  • (PMID = 18027260.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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65. Moon IS, Kim J, Lee HK, Lee WS: Surgical treatment and outcomes of temporal bone chondroblastoma. Eur Arch Otorhinolaryngol; 2008 Dec;265(12):1447-54
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  • [Title] Surgical treatment and outcomes of temporal bone chondroblastoma.
  • Chondroblastoma is an uncommon primary benign bone tumor that usually arises in the epiphyses of the long bones.
  • Temporal bone chondroblastoma is a rare primary bone tumor that affects the floor of the middle cranial fossa and temporomandibular joint (TMJ).
  • The biological nature of temporal bone chondroblastoma is occasionally aggressive because of local invasion and is known to have a high recurrence after curettage.
  • The authors have retrospectively analyzed four cases of temporal bone chondroblastoma that had been completely excised by a single surgeon with an eventual long-term follow-up.
  • In all cases, the tumor involved the middle cranial fossa dura and the mandibular fossa with variable degree of infiltration.
  • All patients have had no tumor recurrence to date (mean follow-up period of 5 years).
  • Complete surgical resection of the temporal bone chondroblastoma is the gold standard for treatment.
  • Precise preoperative image evaluation of tumor extension and proper management of the dura mater and temporomandibular joint (TMJ) are the major important features in complete surgical removal that minimize complications in temporal bone chondroblastoma treatment.
  • [MeSH-major] Chondroblastoma / surgery. Skull Neoplasms / surgery. Temporal Bone

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66. Singh S, Singh R, Sharma PK, Singh UP, Rai SN, Chung LW, Cooper CR, Novakovic KR, Grizzle WE, Lillard JW Jr: Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion. Cancer Lett; 2009 Sep 28;283(1):29-35
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  • We have recently shown that PCa cell lines and primary prostate tumors express CXCR5, which correlates with PCa grade.
  • In this study, we present the first evidence that CXCL13, the only ligand for CXCR5, and IL-6 were significantly elevated in PCa patient serum compared to serum from subjects with benign prostatic hyperplasia (BPH), or high-grade prostatic intraepithelial neoplasia (HGPIN) as well as normal healthy donors (NHD).
  • CXCL13 was highly expressed by human bone marrow endothelial (HBME) cells and osteoblasts (OBs), but not osteoclasts (OCs), following treatment with physiologically relevant levels of interleukin-6 (IL-6).

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  • (PMID = 19375853.001).
  • [ISSN] 1872-7980
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / G12 RR003034-27; United States / NCRR NIH HHS / RR / G12 RR003034-23; United States / NCRR NIH HHS / RR / G12 RR003034; United States / NCI NIH HHS / CA / U24 CA086359-10; United States / NIMHD NIH HHS / MD / P60 MD000525-03; United States / NIMHD NIH HHS / MD / MD00525; United States / NIMHD NIH HHS / MD / P60 MD000525; United States / NIAID NIH HHS / AI / AI057808; United States / NCRR NIH HHS / RR / RR003034-23; United States / NIGMS NIH HHS / GM / S06 GM008248; United States / NIGMS NIH HHS / GM / GM09248; United States / NCRR NIH HHS / RR / RR03034; United States / NIGMS NIH HHS / GM / GM008248-22; United States / NIAID NIH HHS / AI / R01 AI057808; United States / NIDDK NIH HHS / DK / DK58967; United States / NCI NIH HHS / CA / U24CA86359.; United States / NCI NIH HHS / CA / U24 CA086359; United States / NIGMS NIH HHS / GM / GM08248; United States / NIGMS NIH HHS / GM / S06 GM008248-22; United States / NCI NIH HHS / CA / U56 CA092078; United States / NCI NIH HHS / CA / CA086359-10; United States / NCI NIH HHS / CA / CA092078
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CXCL13 protein, human; 0 / CXCR5 protein, human; 0 / Chemokine CXCL13; 0 / Integrins; 0 / Interleukin-6; 0 / Receptors, CXCR5; EC 3.4.21.77 / Prostate-Specific Antigen
  • [Other-IDs] NLM/ NIHMS140687; NLM/ PMC3600557
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67. Moskovszky L, Dezsö K, Athanasou N, Szendröi M, Kopper L, Kliskey K, Picci P, Sápi Z: Centrosome abnormalities in giant cell tumour of bone: possible association with chromosomal instability. Mod Pathol; 2010 Mar;23(3):359-66
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  • [Title] Centrosome abnormalities in giant cell tumour of bone: possible association with chromosomal instability.
  • Giant cell tumour of bone, a benign but potentially aggressive neoplasm, shows an increasing rate of chromosomal aneusomy that correlates with clinical course.
  • Mechanisms that generate chromosomal instability in giant cell tumour of bone are poorly understood.
  • To gain an insight into the possible mechanism for the generation of chromosomal instability in giant cell tumour of bone, we analysed 100 cases, including 57 primary nonrecurrent, 35 recurrent and 8 malignant giant cell tumour of bone cases. gamma-Tubulin immunohistochemistry was performed on tissue microarrays of 59 formalin-fixed paraffin-embedded cases, whereas pericentrin and gamma-tubulin fluorescent immunocytochemistry was carried out on 41 frozen smears.
  • Centrosome amplification was significantly higher in recurrent and malignant giant cell tumour of bones compared with nonrecurrent tumours (P<0.001).
  • These findings indicate that centrosome alteration and frequency of aneusomy correlate with clinical behaviour; the lack of an association between centrosome amplification and chromosome number alteration suggests that alternative causative mechanisms produce genetic instability in giant cell tumour of bone.
  • [MeSH-major] Bone Neoplasms / genetics. Centrosome / pathology. Chromosomal Instability. Giant Cell Tumor of Bone / genetics

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  • (PMID = 20062006.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens; 0 / Tubulin; 0 / pericentrin
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68. Pans S, Brys R, Van Breuseghem I, Geusens E: Benign bone tumours of the spine. JBR-BTR; 2005 Jan-Feb;88(1):31-7
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  • [Title] Benign bone tumours of the spine.
  • A wide variety of primary bone tumours can involve the spine.
  • We present an overview of the primary benign bone tumours of the spine.
  • [MeSH-major] Magnetic Resonance Imaging. Spinal Neoplasms / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Humans. Spinal Diseases / diagnosis

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  • (PMID = 15792167.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 16
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69. Romeo S, Bovée JV, Grogan SP, Taminiau AH, Eilers PH, Cleton-Jansen AM, Mainil-Varlet P, Hogendoorn PC: Chondromyxoid fibroma resembles in vitro chondrogenesis, but differs in expression of signalling molecules. J Pathol; 2005 Jun;206(2):135-42
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  • Chondromyxoid fibroma is a rare benign cartilaginous bone tumour characterized by morphological features that resemble different steps of chondrogenesis in terms of both cellular morphology, ranging from spindled to rounded cells, and the extracellular matrix formed, which ranges from fibrous to cartilaginous.
  • [MeSH-major] Bone Neoplasms / pathology. Chondroblastoma / pathology. Chondrogenesis
  • [MeSH-minor] Cartilage, Articular / cytology. Cell Cycle Proteins / metabolism. Cells, Cultured. Chondrocytes / cytology. Female. Humans. Immunoenzyme Techniques. Male. Neoplasm Proteins / metabolism. Signal Transduction

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  • [Copyright] Copyright 2005 Pathological Society of Great Britain and Ireland
  • (PMID = 15880456.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Neoplasm Proteins
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70. Kossmann N, Gallachi G: [Local pain of the shoulder - osteoid osteoma]. Praxis (Bern 1994); 2010 Mar 17;99(6):359-5; quiz 366
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  • The cause was later identified in CT as being an osteoid osteoma, a benign bone tumour with high vascularity in the core (nidus) and a surrounding region of sclerosis.
  • These tumours usually develop before the age of thirty and the pain responds exquisitely to non-steroidal antirheumatic medication.
  • The tumour was finally removed (CT-guided drilling excision) whereupon the symptoms disappeared.
  • [MeSH-major] Bone Neoplasms / diagnosis. Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Magnetic Resonance Imaging. Osteoma, Osteoid / diagnosis. Scapula / pathology. Shoulder Pain / etiology. Tomography, Spiral Computed
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Young Adult

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  • (PMID = 20235025.001).
  • [ISSN] 1661-8157
  • [Journal-full-title] Praxis
  • [ISO-abbreviation] Praxis (Bern 1994)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 18
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71. Pimenta FJ, Gontijo Silveira LF, Tavares GC, Silva AC, Perdigão PF, Castro WH, Gomez MV, Teh BT, De Marco L, Gomez RS: HRPT2 gene alterations in ossifying fibroma of the jaws. Oral Oncol; 2006 Aug;42(7):735-9
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  • Ossifying fibroma (OF) is a benign neoplasm related to bone characterized by a progressive enlargement of the affected jaw.
  • Recently, the candidate tumor suppressor gene HRPT2 was identified and alterations in this gene were related with the Hyperparathyroidism-jaw tumor syndrome that is characterized by parathyroid adenoma or carcinoma, fibro-osseous lesions (mainly OF) of the jaws, and renal lesions.
  • Tumour and blood samples were obtained from 3 patients with OF and one with juvenile ossifying fibroma (JOF).
  • RT-PCR amplification was performed to analyze HRPT2 mRNA expression and only wild-type HRPT2 transcript was found in all tumours.
  • [MeSH-major] Fibroma, Ossifying / genetics. Genes, Tumor Suppressor. Mandibular Neoplasms / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adolescent. Adult. Female. Gene Expression. Humans. Male. Middle Aged. Mutation. RNA, Messenger / genetics. RNA, Neoplasm / genetics. Reverse Transcriptase Polymerase Chain Reaction / methods

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  • (PMID = 16458039.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CDC73 protein, human; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Tumor Suppressor Proteins
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72. Zafatayeff-Hasbani S, Ducou Le Pointe H, Josset P, Damsin JP, Montagne JP: Intra-articular recurrence of benign chondroblastoma with articular involvement at initial presentation--a case report. Eur J Pediatr Surg; 2006 Aug;16(4):291-3
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  • [Title] Intra-articular recurrence of benign chondroblastoma with articular involvement at initial presentation--a case report.
  • Intra-articular and soft tissue recurrence occurred after treatment consisting of curettage and bone grafting.
  • [MeSH-major] Bone Neoplasms / pathology. Chondrosarcoma / pathology. Tibia
  • [MeSH-minor] Adolescent. Curettage. Epiphyses / pathology. Humans. Knee Joint. Male. Neoplasm Recurrence, Local. Neoplasm Seeding. Soft Tissue Neoplasms / pathology

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  • (PMID = 16981100.001).
  • [ISSN] 0939-7248
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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73. Simmons C, Amir E, Dranitsaris G, Clemons M, Wong B, Veith R, Cole DE: Altered calcium metabolism in patients on long-term bisphosphonate therapy for metastatic breast cancer. Anticancer Res; 2009 Jul;29(7):2707-11
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  • BACKGROUND: Bisphosphonates (BPs) are considered the standard of care in metastatic breast cancer (MBC) patients with bone metastases.
  • These results were compared to a historical control group of 420 patients without bone or mineral disease who were matched for gender, age, baseline renal function and season of seological testing.
  • CONCLUSION: In MBC patients with prolonged BP use, there appears to be a state of hyperparathyroidism similar to that seen with BP use in benign bone disease.
  • [MeSH-major] Breast Neoplasms / metabolism. Calcium / metabolism. Diphosphonates / therapeutic use. Neoplasm Metastasis / drug therapy


74. Bonekamp D, Jacene H, Bartelt D, Aygun N: Conversion of FDG PET activity of fibrous dysplasia of the skull late in life mimicking metastatic disease. Clin Nucl Med; 2008 Dec;33(12):909-11
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  • Fibrous dysplasia (FD) accounts for 7% of benign bone tumors.
  • It is a developmental disorder of unclear etiology.
  • The lamellar cancellous bone of the medullary cavity is replaced with immature fibroosseous tissue.
  • We describe a case of FD of the skull in a patient of advanced age (69 years) with recent diagnosis of colon cancer, which changed its FDG activity and CT appearance within 10 months of follow-up.
  • [MeSH-major] Fibrous Dysplasia of Bone / radionuclide imaging. Fluorodeoxyglucose F18. Molecular Mimicry. Neoplasm Metastasis / pathology. Positron-Emission Tomography. Skull / pathology. Skull / radionuclide imaging

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  • (PMID = 19033807.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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75. Kitsoulis P, Mantellos G, Vlychou M: Osteoid osteoma. Acta Orthop Belg; 2006 Apr;72(2):119-25
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  • Osteoid osteoma is a relatively frequent benign bone tumour, consisting of osteoid and woven bone, and surrounded by a halo of reactive sclerotic bone, with an average size of the nidus less than 1.5 cm.
  • [MeSH-major] Bone Neoplasms. Osteoma, Osteoid

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  • (PMID = 16768252.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 42
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76. Li JS, Sun GW, Wei XY, Tang WH: Expression of periostin and its clinicopathological relevance in gastric cancer. World J Gastroenterol; 2007 Oct 21;13(39):5261-6
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  • Immunohistochemistry was performed to localize and quantify the expression of periostin in benign gastric diseases and gastric cancer, and immunostaining results were correlated with gastric cancer pathological stages.
  • Immunohistochemical staining revealed that periostin was overexpressed in primary gastric cancer, as well as in metastatic lymph nodes, but only faint staining was found in benign gastric ulcers.
  • By quantitative analysis of the immunostaining results, periostin expression was increased 2.5-4-fold in gastric cancer, compared to that in benign gastric disease, and there was a trend toward increasing periostin expression with tumor stage.
  • [MeSH-minor] Aged. Disease Progression. Female. Gene Expression Regulation, Neoplastic. Humans. Lymph Nodes / metabolism. Lymph Nodes / pathology. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Staging. RNA, Messenger / genetics. RNA, Messenger / metabolism. Stomach / metabolism. Stomach / pathology

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  • (PMID = 17876898.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cell Adhesion Molecules; 0 / POSTN protein, human; 0 / RNA, Messenger
  • [Other-IDs] NLM/ PMC4171309
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77. Ando A, Hatori M, Hosaka M, Hagiwara Y, Kita A, Itoi E: Eosinophilic granuloma arising from the pelvis in children: A report of three cases. Ups J Med Sci; 2008;113(2):209-16
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  • Eosinophilic granuloma (EG) is a benign tumor-like condition which is characterized by a clonal proliferation of Langerhans-type histiocytes and defined as a local form of Langerhans cell histiocytosis (LCH).
  • A status of EG in the bone is divided into acute and chronic phases.
  • Radiologically acute phase of EG is difficult to differentiate from a malignant bone tumor such as Ewing's sarcoma or acute osteomyelitis.
  • Chronic phase of EG may mimic a chronic osteomyelitis or a benign bone tumor.
  • These lesions resembled radiologically chronic osteomyelitis (Brodie's abscess) or a benign bone tumor and healed spontaneously after biopsy.
  • It was difficult to differentiate from a malignant tumor such as Ewing's sarcoma, or acute osteomyelitis.
  • Curettage of the affected site and bone grafting is usually accomplished.
  • [MeSH-major] Bone Neoplasms / complications. Eosinophilic Granuloma / etiology. Osteomyelitis / complications. Pelvis

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  • (PMID = 18509815.001).
  • [ISSN] 2000-1967
  • [Journal-full-title] Upsala journal of medical sciences
  • [ISO-abbreviation] Ups. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
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78. Freschi S, Dodson NB: Osteoid osteoma: an uncommon cause of foot pain. J Am Podiatr Med Assoc; 2007 Sep-Oct;97(5):405-9
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  • An osteoid osteoma located in the forefoot can be difficult to diagnose, and the diagnosis is frequently delayed.
  • Although rarely seen in the metatarsal, osteoid osteoma should be included in the differential diagnosis of foot pain.
  • Findings from radiographs, magnetic resonance images, and a detailed clinical history led to the diagnosis of osteoid osteoma of the left second metatarsal.
  • We review osteoid osteoma, including the classic clinical presentation and treatment associated with this benign bone tumor.

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  • (PMID = 17901347.001).
  • [ISSN] 8750-7315
  • [Journal-full-title] Journal of the American Podiatric Medical Association
  • [ISO-abbreviation] J Am Podiatr Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Settakorn J, Lekawanvijit S, Arpornchayanon O, Rangdaeng S, Vanitanakom P, Kongkarnka S, Cheepsattayakorn R, Ya-In C, Thorner PS: Spectrum of bone tumors in Chiang Mai University Hospital, Thailand according to WHO classification 2002: A study of 1,001 cases. J Med Assoc Thai; 2006 Jun;89(6):780-7
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  • [Title] Spectrum of bone tumors in Chiang Mai University Hospital, Thailand according to WHO classification 2002: A study of 1,001 cases.
  • OBJECTIVE: The aim of the present study was to determine the spectrum, frequency and demographics of bone tumors.
  • MATERIAL AND METHOD: A retrospective study of the 1,001 bone tumor specimens from the files at the Pathology Department of the Chiang Mai University Hospital, Thailand from 2000 to 2004.
  • RESULTS: From the study, 41 were non-neoplastic mass lesions, and 960 were neoplastic, with 856 (89%) as primary and 104 (11%) as metastatic tumors.
  • In the primary tumor group, 654 (76%) cases were of hematologic origin, and 202 (24%) were non-hematologic.
  • The most common benign bone tumors were giant cell tumor (n = 37), osteochondroma (n = 25), and chondroma (n = 15).
  • The most common malignant bone tumors were lymphoma-leukemia (n = 583), metastatic malignancy (n = 104), plasma cell myeloma (n = 71), and osteosarcoma (n = 58).
  • CONCLUSION: The present study showed a higher frequency of osteosarcoma (68%), lower frequencies of chondrosarcoma (12%) and Ewing sarcoma (4%) among primary non-hematologic malignant bone tumors when compared with similar studies based on Western patients.
  • [MeSH-major] Bone Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Giant Cell Tumors / diagnosis. Giant Cell Tumors / epidemiology. Hospitals, University. Humans. Infant. Male. Middle Aged. Osteochondroma / diagnosis. Osteochondroma / epidemiology. Osteosarcoma / diagnosis. Osteosarcoma / epidemiology. Retrospective Studies. Thailand / epidemiology. World Health Organization

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  • (PMID = 16850677.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Thailand
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80. Weber K, Damron TA, Frassica FJ, Sim FH: Malignant bone tumors. Instr Course Lect; 2008;57:673-88
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  • [Title] Malignant bone tumors.
  • Malignant bone tumors represent a small percentage of cancers nationwide and also are much less common than malignant soft-tissue tumors.
  • The most common primary malignant bone tumors, osteosarcoma and Ewing's sarcoma, occur in childhood.
  • Rare tumors such as chordoma and adamantinoma have anatomic predilections for the sacrum and tibia, respectively.
  • The primary symptom of a patient with a malignant bone tumor is pain, which often occurs at rest or at night.
  • Patients with a likely malignancy require thorough staging to determine the extent of disease and a well-planned biopsy for accurate diagnosis.
  • Knowledge of specific tumor characteristics and treatment options for osteosarcoma, Ewing's sarcoma, chondrosarcoma, malignant fibrous histiocytoma, chordoma, and adamantinoma is important.
  • Secondary sarcomas can occur in previously benign bone lesions and require aggressive treatment.
  • Specific techniques are available for the resection of malignant bone tumors from the upper extremities, lower extremities, pelvis, and spine.
  • The care of patients with primary malignant bone tumors requires a multidisciplinary approach to treatment.
  • [MeSH-major] Bone Neoplasms. Orthopedic Procedures / methods
  • [MeSH-minor] Global Health. Humans. Morbidity. Neoplasm Staging / methods. Prognosis

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  • (PMID = 18399615.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 42
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81. Sanatkumar S, Rajagopalan N, Mallikarjunaswamy B, Srinivasalu S, Sudhir NP, Usha K: Benign fibrous histiocytoma of the distal radius with congenital dislocation of the radial head: a case report. J Orthop Surg (Hong Kong); 2005 Apr;13(1):83-7
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  • [Title] Benign fibrous histiocytoma of the distal radius with congenital dislocation of the radial head: a case report.
  • Benign fibrous histiocytoma is such a rare tumour that only a few cases have been reported in the literature.
  • A patient with an apparently benign lesion of the distal radius, along with congenital dislocation of the radial head, was presented at St. John's Medical College Hospital in Bangalore, India.
  • [MeSH-major] Amputation. Bone Neoplasms / surgery. Histiocytoma, Benign Fibrous / surgery. Neoplasm Recurrence, Local / surgery. Orthopedic Procedures / adverse effects

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  • (PMID = 15872408.001).
  • [ISSN] 1022-5536
  • [Journal-full-title] Journal of orthopaedic surgery (Hong Kong)
  • [ISO-abbreviation] J Orthop Surg (Hong Kong)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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82. Yamaguchi T, Watanabe-Ishiiwa H, Suzuki S, Igarashi Y, Ueda Y: Incipient chordoma: a report of two cases of early-stage chordoma arising from benign notochordal cell tumors. Mod Pathol; 2005 Jul;18(7):1005-10
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  • [Title] Incipient chordoma: a report of two cases of early-stage chordoma arising from benign notochordal cell tumors.
  • Chordomas are rare malignant bone tumors primarily involving both ends of the axial skeleton that present as destructive bone lesions with a large soft tissue mass.
  • However, recent studies suggest the possibility that chordomas arise from benign notochordal cell tumors.
  • The coccygeal tumors were composed of intraosseous and extraosseous infiltrative lesions.
  • The intraosseous lesions consisted of both benign notochordal cell tumor and incipient chordoma.
  • In addition, two other small benign notochordal cell tumors were found at a different level in case 1.
  • It is conceivable that pre-existing intraosseous benign notochordal cell tumors transform into incipient chordoma and then extend through the cortex into the surrounding soft tissue.
  • The incidence of incipient chordoma appears much higher than expected because chordomas are rare tumors with an incidence of one case per 1 000 000 persons per year.
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma, Hepatocellular / complications. Coccyx. Fatal Outcome. Humans. Liver Neoplasms / complications. Male. Neoplasm Staging. Notochord / pathology. Prostatic Neoplasms / complications

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  • (PMID = 15803192.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Gümgüm S, Hoşgören B: Clinical and radiologic behaviour of ameloblastoma in 4 cases. J Can Dent Assoc; 2005 Jul-Aug;71(7):481-4
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  • Ameloblastoma is a benign but locally aggressive epithelial odontogenic neoplasm.
  • It represents 1% of all tumours of the jaw bone.
  • It can be treated by enucleation, bone curettage or wide resection.
  • We describe the clinical and radiologic behaviour of ameloblastoma and discuss treatment protocols and the possibility of conservative management of this tumour.

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  • (PMID = 16026635.001).
  • [ISSN] 1488-2159
  • [Journal-full-title] Journal (Canadian Dental Association)
  • [ISO-abbreviation] J Can Dent Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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84. Harzallah L, Bouajina E, Rammeh N, Belhadj SK, Ghannouchi M, Kraiem C: [Iliac chondroma: a case report]. Tunis Med; 2005 Sep;83(9):578-80
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  • Chondroma is a benign bone tumour that usually occurs in the in carpal and phalangeal bones.
  • The diagnosis of chondroma was confirmed after surgical biopsy.
  • [MeSH-major] Bone Neoplasms / pathology. Chondroma / pathology. Ilium / pathology

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  • (PMID = 16383207.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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85. Fine HF, Ferrara DC, Ho IV, Takahashi B, Yannuzzi LA: Bilateral choroidal osteomas with polypoidal choroidal vasculopathy. Retin Cases Brief Rep; 2008;2(1):15-7
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  • BACKGROUND: A choroidal osteoma is a benign osseous tumor typically arising in the juxtapapillary or peripapillary area.
  • To our knowledge, this variant form of vasogenesis has not previously been described in association with this tumor.

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  • (PMID = 25389606.001).
  • [ISSN] 1935-1089
  • [Journal-full-title] Retinal cases & brief reports
  • [ISO-abbreviation] Retin Cases Brief Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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86. Nissan A, Jager D, Roystacher M, Prus D, Peretz T, Eisenberg I, Freund HR, Scanlan M, Ritter G, Old LJ, Mitrani-Rosenbaum S: Multimarker RT-PCR assay for the detection of minimal residual disease in sentinel lymph nodes of breast cancer patients. Br J Cancer; 2006 Mar 13;94(5):681-5
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  • RNA was extracted from 30 sentinel lymph nodes (SLN) obtained from 28 patients, three primary breast cancers (positive controls), three lymph nodes from patients with benign diseases, and peripheral blood lymphocytes of 10 healthy volunteers (negative controls).
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Biomarkers, Tumor / analysis. Breast Neoplasms / genetics. Breast Neoplasms / pathology. Sentinel Lymph Node Biopsy
  • [MeSH-minor] Case-Control Studies. DNA Primers. Female. Humans. Immunohistochemistry. Lymph Nodes / pathology. Lymphatic Metastasis. Neoplasm Staging / methods. Neoplasm, Residual. Reverse Transcriptase Polymerase Chain Reaction. Sensitivity and Specificity

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  • (PMID = 16495929.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA Primers
  • [Other-IDs] NLM/ PMC2361196
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87. Arantes M, Resende M, Honavar M, Pires MM, Pereira JR, Vaz AR: Benign osteoblastoma of the sphenoid bone. Skull Base; 2009 Nov;19(6):437-41
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  • [Title] Benign osteoblastoma of the sphenoid bone.
  • Osteoblastoma is an uncommon benign bone tumor that accounts for 1% of all primary bone tumors.
  • Well documented in the spine and long bones, it is rarely found in the skull, namely in the sphenoid bone, with only five cases reported in the literature.
  • We report a case of an 11-year-old girl with a histologically confirmed benign osteoblastoma in an unusual location and an atypical aspect on the imaging studies.

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  • [Cites] Cancer. 1956 Sep-Oct;9(5):1044-52 [13364889.001]
  • (PMID = 20436846.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2793891
  • [Keywords] NOTNLM ; Benign osteoblastoma / child / radical resection / sphenoid bone
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88. Wootton-Gorges SL: MR imaging of primary bone tumors and tumor-like conditions in children. Magn Reson Imaging Clin N Am; 2009 Aug;17(3):469-87, vi
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  • [Title] MR imaging of primary bone tumors and tumor-like conditions in children.
  • This article provides a review of the MR imaging features of the major primary malignant and benign bone tumors and tumorlike conditions encountered in the pediatric population.
  • Malignant tumors discussed include osteosarcoma, Ewing sarcoma, chondrosarcoma, lymphoma, and malignant fibrous histiocytoma.
  • Benign lesions discussed include simple bone cysts, aneurysmal bone cysts, giant cell tumor, osteochondroma, enchondroma, chondroblastoma, osteoid osteoma, osteoblastoma, nonossifying fibroma, fibrous dysplasia, osteofibrous dysplasia, hemangioma, and histiocytosis.
  • The use of MR imaging in the diagnosis of these lesions is discussed, and the text is enhanced with imaging examples of the lesions.
  • [MeSH-major] Bone Neoplasms / diagnosis. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Adolescent. Bone Cysts / diagnosis. Bone Cysts / pathology. Cartilage Diseases / diagnosis. Cartilage Diseases / pathology. Child. Contrast Media. Humans

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  • (PMID = 19524197.001).
  • [ISSN] 1557-9786
  • [Journal-full-title] Magnetic resonance imaging clinics of North America
  • [ISO-abbreviation] Magn Reson Imaging Clin N Am
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 44
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89. Zegn W, Li G, Liu Z, Gao CH: [Bone morphogenetic protein compunds combined with autologous red bone marrow graft for treatment of benign bone tumors and tumor-like lesions in limbs]. Zhongguo Gu Shang; 2010 Oct;23(10):788-9
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  • [Title] [Bone morphogenetic protein compunds combined with autologous red bone marrow graft for treatment of benign bone tumors and tumor-like lesions in limbs].
  • [MeSH-major] Bone Marrow Transplantation / immunology. Bone Morphogenetic Proteins / therapeutic use. Bone Neoplasms / therapy. Combined Modality Therapy. Transplantation, Autologous / immunology

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  • (PMID = 21137298.001).
  • [ISSN] 1003-0034
  • [Journal-full-title] Zhongguo gu shang = China journal of orthopaedics and traumatology
  • [ISO-abbreviation] Zhongguo Gu Shang
  • [Language] chi
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Bone Morphogenetic Proteins
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90. Faik A, Mahfoud Filali S, Lazrak N, El Hassani S, Hajjaj-Hassouni N: Spinal cord compression due to vertebral osteochondroma: report of two cases. Joint Bone Spine; 2005 Mar;72(2):177-9
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  • Osteochondroma, or exostosis, is the most common of all benign bone tumors.

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  • (PMID = 15797501.001).
  • [ISSN] 1297-319X
  • [Journal-full-title] Joint, bone, spine : revue du rhumatisme
  • [ISO-abbreviation] Joint Bone Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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91. Sioud S, Bertolus C, Gruffaz F, Ghoul S, Menard P, Bertrand JC, Ruhin B: [Giant-cell tumors: three recurrent cases in young patients]. Rev Stomatol Chir Maxillofac; 2007 Apr;108(2):131-4
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  • [Title] [Giant-cell tumors: three recurrent cases in young patients].
  • [Transliterated title] Tumeurs à cellules géantes: à propos de trois cas récidivants chez des sujets jeunes.
  • INTRODUCTION: True giant-cell tumor is a rare jaw osteolytic benign tumor belonging to the larger family of giant-cell tumors.
  • OBSERVATION: Since 1973, we have managed four cases of true giant-cell tumors in our unit.
  • DISCUSSION: Based on a literature review we defined this entity among the other giant-cell tumors.
  • We emphasize the importance of early definitive diagnosis based on rigorous clinical and radiological confrontations.
  • Because of its benign nature, the most conservative surgical treatment (tumorectomy-curettage) is generally proposed for the young patient.
  • We noted however that in the three cases presented here, more radical surgical treatment with an enlarged tumorectomy removing the adjacent bone was advisable because of the high risk of recurrence and metastasis.
  • [MeSH-major] Giant Cell Tumor of Bone / pathology. Jaw Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans. Male. Neoplasm Recurrence, Local

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  • (PMID = 17320127.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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92. Xu J, Xu CR, Wu H, Pan HL, Tian J: Osteochondroma in the lumbar intraspinal canal causing nerve root compression. Orthopedics; 2009 Feb;32(2):133
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  • Osteochondromas, which are benign bone tumors that usually develop on long bones, tubular bones, are rarely found in the spine.
  • Considering differential diagnosis, lumbar facet synovial cysts must be excluded as they can also cause myeloradiculopathy with the similar mechanism.
  • The tumor, approximately 6x7x11 mm, was identified after laminectomy of the L5 laminae.
  • Postoperative histopathologic examination confirmed our hypothesis of benign osteochondroma.
  • Computed tomography and MRI are helpful for the preoperatively precise indication of tumor extent and its relationships with the adjacent.

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  • (PMID = 19301786.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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93. Kim J, Kumar R, Raymond AK, Ayala AG: Non-epiphyseal chondroblastoma arising in the iliac bone, and complicated by an aneurysmal bone cyst: a case report and review of the literature. Skeletal Radiol; 2010 Jun;39(6):583-7
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  • [Title] Non-epiphyseal chondroblastoma arising in the iliac bone, and complicated by an aneurysmal bone cyst: a case report and review of the literature.
  • Chondroblastoma is a benign bone tumor that typically arises in the epiphysis of a long bone.
  • We describe such a case of chondroblastoma arising in the iliac bone.
  • The radiographs and CT revealed an expansile lytic lesion in the right iliac bone.
  • The histopathology revealed the lesion to be a chondroblastoma with secondary features of aneurysmal bone cyst.
  • An en bloc surgical resection of the tumor was performed.
  • [MeSH-major] Bone Cysts, Aneurysmal / complications. Bone Cysts, Aneurysmal / diagnostic imaging. Bone Neoplasms / complications. Bone Neoplasms / diagnostic imaging. Chondroblastoma / complications. Chondroblastoma / diagnostic imaging. Ilium / diagnostic imaging. Tomography, X-Ray Computed

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  • [Cites] Skeletal Radiol. 2006 Jan;35(1):49-52 [16010594.001]
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  • (PMID = 19936740.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 12
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94. Niethard M, Rogalski M, Deja M, Zacher J: [Partial physeal growth arrest with increasing genu varum deformity caused by a cortical enchondroma--a case report]. Z Orthop Unfall; 2008 Nov-Dec;146(6):725-9
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  • The X-ray and MRI investigations have shown a benign lesion like osteofibroma of the mediodistal femur with an affection of the medial physis.
  • 1) resection of the benign lesion and arthroscopically assisted resection of the bony bar with fat-patch interposition;.
  • CONCLUSION: In cases of rare partial bridging of the physis induced by a benign bone tumour one can achieve early correction of axial deviation during growth with resection, interposition of a fat patch and temporary hemiepiphyseodesis.
  • [MeSH-major] Arthroscopy. Bone Malalignment / surgery. Bone Plates. Cartilage, Articular / surgery. Chondroma / surgery. Femur / surgery. Growth Plate / surgery. Knee Joint / surgery

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  • (PMID = 19085720.001).
  • [ISSN] 1864-6697
  • [Journal-full-title] Zeitschrift für Orthopädie und Unfallchirurgie
  • [ISO-abbreviation] Z Orthop Unfall
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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95. Figl M, Leixnering M: Retrospective review of outcome after surgical treatment of enchondromas in the hand. Arch Orthop Trauma Surg; 2009 Jun;129(6):729-34
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  • BACKGROUND: Tumours of the skeleton of the hand are rare.
  • While the majority of bone tumours are benign (89.4%), a small number show signs of malignancy (4.4%).
  • Among the benign bone tumours of the skeleton of the hand, enchondromas are the most common, at 35-65%.
  • The most common site of an enchondroma was the proximal phalanx in 17 cases, followed by the metacarpal bone in 8 cases and the middle phalanx in 5 cases.
  • For accurate diagnosis, conventional X-ray examination and if necessary, a contrast medium MRI should be performed.
  • Depending on its spread, the defect in the extirpation cavity should be filled with autogenous spongy bone.
  • [MeSH-major] Bone Neoplasms / surgery. Chondroma / surgery. Hand / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Transplantation. Female. Fingers / pathology. Fingers / surgery. Fractures, Spontaneous / diagnosis. Fractures, Spontaneous / pathology. Fractures, Spontaneous / surgery. Hand Injuries / diagnosis. Hand Injuries / pathology. Hand Injuries / surgery. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 18726106.001).
  • [ISSN] 1434-3916
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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96. Meller I, Weinbroum A, Bickels J, Dadia S, Nirkin A, Merimsky O, Issakov J, Flusser G, Marouani N, Cohen N, Kollender Y: Fifteen years of bone tumor cryosurgery: a single-center experience of 440 procedures and long-term follow-up. Eur J Surg Oncol; 2008 Aug;34(8):921-7
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  • [Title] Fifteen years of bone tumor cryosurgery: a single-center experience of 440 procedures and long-term follow-up.
  • BACKGROUND: This summary of a single center's extensive cumulative experience in bone tumor cryosurgery assesses the long-term outcome of bone conservation surgery in which adjuvant cryosurgery plays a pivotal role.
  • Two-thirds of the series comprised a variety of primary benign-aggressive and low-grade malignant lesions, and one-third were primary high-grade and metastatic bone tumors.
  • The anatomical locations included almost every bone of the skeleton.
  • Two methods of bone cryosurgery were used: Marcove's "open" direct-pour system using liquid nitrogen (1988-1997) and Meller's "closed" argon-based system (1998 to the present).
  • The functional outcome for the 372 patients with no evidence of disease was almost 100% "good" and "excellent" (American Musculo-skeletal Tumor Society System).
  • CONCLUSIONS: Bone cryosurgery is a safe and effective limb-, joint- and even epiphysis-sparing surgical technique in suitable types of bone tumors, temporarily or permanently obviating the need for resection surgery.
  • [MeSH-major] Bone Neoplasms / surgery. Cryosurgery. Neoplasm Recurrence, Local

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  • (PMID = 18158228.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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97. Rodríguez Paramás A, Lendoiro Otero C, González García JA, Souviron Encabo R, Scola Yurrita B: [Temporal bone chondroblastoma. A clinical case and literature review]. Acta Otorrinolaringol Esp; 2006 Aug-Sep;57(7):336-8
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  • [Title] [Temporal bone chondroblastoma. A clinical case and literature review].
  • [Transliterated title] Condroblastoma de hueso temporal. Caso clínico y revisión de la literatura.
  • After radiologic diagnosis, intraoperatory biopsy and surgical removal, the anatomopathological result confirmed the histology of chondroblatoma, with a satisfactory postoperative evolution.
  • The chondroblastoma is a benign bone tumor typically located in the epiphysis of long bones and the temporal bone is an excepcional location as we have verified through a literature review.
  • [MeSH-major] Chondroblastoma. Skull Neoplasms. Temporal Bone

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  • (PMID = 17036998.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 9
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98. Bagaria V, Harshvardhna NS, Desai M, Sonowane S: Transphyseal spread of benign tumors and infections in pediatric patients: a series of six cases. Indian J Med Sci; 2005 Jun;59(6):259-64
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  • [Title] Transphyseal spread of benign tumors and infections in pediatric patients: a series of six cases.
  • Epiphyseal extension of benign pathology is regarded as an infrequent occurrence.
  • We report a retrospective series of six patients over a period of 4 years, diagnosed with benign pathologies that showed crossing of an open physeal plate by the disease.
  • Four of these cases were infections and two were benign tumors.
  • The recognition of the fact that benign tumors may occasionally present with transphyseal spread will prevent unjustified radical procedures that are best reserved for aggressive malignant conditions.
  • [MeSH-major] Bone Cysts / pathology. Bone Neoplasms / pathology. Chondroblastoma / pathology. Growth Plate / microbiology. Growth Plate / pathology. Tuberculosis, Osteoarticular / pathology
  • [MeSH-minor] Child. Child, Preschool. Humans. Male. Neoplasm Invasiveness

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  • (PMID = 15988096.001).
  • [ISSN] 0019-5359
  • [Journal-full-title] Indian journal of medical sciences
  • [ISO-abbreviation] Indian J Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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99. Ramboaniaina S, Hoang DV, Berger M: [Aneurysmal carpal scaphoid cyst. A case report]. Chir Main; 2009 Feb;28(1):46-9
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  • Aneurysmal bone cyst is a rare, benign bone tumor and its location in the carpal scaphoid has never been described in the literature.
  • [MeSH-major] Bone Cysts, Aneurysmal / diagnosis. Scaphoid Bone / radiography

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  • (PMID = 19095484.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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100. Schnirring-Judge M, Visser J: Resection and reconstruction of an osteochondroma of the hallux: a review of benign bone tumors and a description of an unusual case. J Foot Ankle Surg; 2009 Jul-Aug;48(4):495-505
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  • [Title] Resection and reconstruction of an osteochondroma of the hallux: a review of benign bone tumors and a description of an unusual case.
  • Osteochondroma, which is also known as exostosis, is the most common benign bone tumor.
  • In this review, we describe the clinical and diagnostic imaging characteristics of benign bone tumors and, in particular, the osteochondroma and its surgical management.
  • [MeSH-major] Bone Neoplasms / surgery. Hallux / surgery. Osteochondroma / surgery
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Neoplasms, Post-Traumatic / pathology. Young Adult

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  • (PMID = 19577730.001).
  • [ISSN] 1542-2224
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 36
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