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1. Sander R: Good gastrostomy technique. Nurs Older People; 2009 Sep 23;21(7):13
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  • Percutaneous endoscopic gastrostomy (PEG) provides direct access to the stomach by the formation of a fistula through the abdominal wall.
  • The tube is retained in the stomach by a small disc and externally by a movable fixation device.

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  • (PMID = 27736535.001).
  • [ISSN] 1472-0795
  • [Journal-full-title] Nursing older people
  • [ISO-abbreviation] Nurs Older People
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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2. Sala FG, Kunisaki SM, Ochoa ER, Vacanti J, Grikscheit TC: Tissue-engineered small intestine and stomach form from autologous tissue in a preclinical large animal model. J Surg Res; 2009 Oct;156(2):205-12
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  • [Title] Tissue-engineered small intestine and stomach form from autologous tissue in a preclinical large animal model.
  • BACKGROUND: Tissue-engineered small intestine, stomach, large intestine, esophagus, and gastroesophageal (GE) junction have been successfully formed from syngeneic cells, and employed as a rescue therapy in a small animal model.
  • The purpose of this study is to determine if engineered intestine and stomach could be generated in an autologous, preclinical large animal model, and to identify if the tissue-engineered intestine retained features of an intact stem cell niche.
  • METHODS: A short segment of jejunum or stomach was resected from 6-wk-old Yorkshire swine.
  • RESULTS: Autologous engineered small intestine and stomach formed.
  • Finally, tissue-engineered stomach also formed with antral-type mucosa (mucus cells and surface foveolar cells) and a muscularis.
  • [MeSH-major] Jejunum / physiology. Regeneration. Stomach / physiology. Tissue Engineering

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  • (PMID = 19665143.001).
  • [ISSN] 1095-8673
  • [Journal-full-title] The Journal of surgical research
  • [ISO-abbreviation] J. Surg. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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3. Kishore J, Dash NR, Saxena R, Krishnani N: Novel detection of parvovirus B19 DNA & IgM antibodies in patients with non-occlusive gangrene of stomach & bowel. Indian J Med Res; 2010 May;131:702-10
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  • [Title] Novel detection of parvovirus B19 DNA & IgM antibodies in patients with non-occlusive gangrene of stomach & bowel.
  • BACKGROUND: Gangrene of stomach or intestines owing to non-occlusive bowel infarction (NOBI) is a rare event with unknown etiology.
  • Histopathology showed loss of bowel mucosa and crypts with inflammatory cell infiltration besides fibrin thrombus in gastric vessels.
  • [MeSH-major] Colonic Diseases / immunology. Gangrene / immunology. Immunoglobulin M / immunology. Parvovirus B19, Human / immunology. Stomach Diseases / immunology

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  • (PMID = 20516544.001).
  • [ISSN] 0971-5916
  • [Journal-full-title] The Indian journal of medical research
  • [ISO-abbreviation] Indian J. Med. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Immunoglobulin M
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4. Arancibia V, Peña C, Segura R: Evaluation of powdered infant formula milk as chelating agent for copper under simulated gastric conditions of a baby's stomach. Anal Sci; 2006 Sep;22(9):1197-200
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  • [Title] Evaluation of powdered infant formula milk as chelating agent for copper under simulated gastric conditions of a baby's stomach.
  • Milk solutions were prepared following the instructions shown on the milk container, and they were mixed with a pepsin solution simulating a baby's stomach conditions (pepsin and salts concentration, pH and temperature).
  • [MeSH-major] Chelating Agents / pharmacology. Copper / metabolism. Infant Formula. Stomach / physiology

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  • (PMID = 16966809.001).
  • [ISSN] 0910-6340
  • [Journal-full-title] Analytical sciences : the international journal of the Japan Society for Analytical Chemistry
  • [ISO-abbreviation] Anal Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Chelating Agents; 789U1901C5 / Copper
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5. Toyomasu Y, Mochiki E, Yanai M, Ogata K, Tabe Y, Ando H, Ohno T, Aihara R, Zai H, Kuwano H: Intragastric monosodium L-glutamate stimulates motility of upper gut via vagus nerve in conscious dogs. Am J Physiol Regul Integr Comp Physiol; 2010 Apr;298(4):R1125-35
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  • MSG (5, 15, 45, and 90 mM/kg) dissolved in water was injected into the stomach and duodenum in normal and vagotomized dogs.
  • MSG solution was administered into the stomach before feeding, and gastric emptying was evaluated.
  • Several inhibitors of gastrointestinal motility (atropine, hexamethonium, and granisetron) were injected intravenously before MSG administration to the stomach.
  • Intragastric MSG (45 mM/kg) stimulated postprandial motility and accelerated gastric emptying.
  • We conclude that intragastric MSG stimulates upper gut motility and accelerates gastric emptying.
  • The sensory structure of MSG is present in the gastric corpus, and the signal is mediated by the vagus nerve.
  • [MeSH-major] Gastric Emptying / drug effects. Gastrointestinal Motility / physiology. Sodium Glutamate / pharmacology. Vagus Nerve / physiology
  • [MeSH-minor] Animals. Atropine / pharmacology. Dogs. Injections, Intravenous. Muscle Contraction / drug effects. Reference Values. Serotonin / blood. Stomach / drug effects. Stomach / innervation. Stomach / physiology

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  • (PMID = 20071606.001).
  • [ISSN] 1522-1490
  • [Journal-full-title] American journal of physiology. Regulatory, integrative and comparative physiology
  • [ISO-abbreviation] Am. J. Physiol. Regul. Integr. Comp. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 333DO1RDJY / Serotonin; 7C0697DR9I / Atropine; W81N5U6R6U / Sodium Glutamate
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6. Soulard R, Claude V, Camparo P, Dufau JP, Saint-Blancard P, Gros P: Primitive neuroectodermal tumor of the stomach. Arch Pathol Lab Med; 2005 Jan;129(1):107-10
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  • [Title] Primitive neuroectodermal tumor of the stomach.
  • Ewing sarcoma/primitive neuroectodermal tumor is classically a tumor of the soft tissue or bone in children and young adults, but several cases have been described in patients of all ages.
  • Within the last decade, the clinicopathologic spectrum of Ewing sarcoma/primitive neuroectodermal tumor has been markedly expanded by recognition that the tumor may also have a visceral origin.
  • We describe a case of primitive neuroectodermal tumor arising in the stomach of a 66-year-old woman.
  • The neoplasm was excised using a radical surgical procedure.
  • Microscopically, the tumor was made up of solid nests and sheets of round cells.
  • Immunohistochemically, the tumor cells showed immunoreactivity for CD99, S100, neuron-specific enolase, and vimentin.
  • To our knowledge, this is the first description of a primitive neuroectodermal tumor arising in the stomach.
  • [MeSH-major] Neuroectodermal Tumors, Primitive / diagnosis. Stomach Neoplasms / diagnosis

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  • (PMID = 15628889.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Rossi M, Rosato V, Bosetti C, Lagiou P, Parpinel M, Bertuccio P, Negri E, La Vecchia C: Flavonoids, proanthocyanidins, and the risk of stomach cancer. Cancer Causes Control; 2010 Oct;21(10):1597-604
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  • [Title] Flavonoids, proanthocyanidins, and the risk of stomach cancer.
  • Flavonoids have been suggested to be responsible for the potential beneficial properties of fruit and vegetables on stomach cancer risk.
  • To provide further information on flavonoids, proanthocyanidins, and gastric cancer risk, we analyzed data from a case-control study conducted in Italy.
  • Subjects were 230 cases with incident, histologically confirmed gastric cancer and 547 frequency-matched controls, admitted to the same hospitals of cases for acute, non-neoplastic conditions.
  • We estimated the odds ratios (ORs) of gastric cancer and their corresponding 95% confidence intervals (CIs) using unconditional logistic regression models including terms for major recognized gastric cancer risk factors.
  • This is the first epidemiological study to suggest that dietary proanthocyanidins have a favorable role on gastric cancer risk.
  • [MeSH-major] Diet. Flavonoids. Proanthocyanidins. Stomach Neoplasms / epidemiology

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  • (PMID = 20521092.001).
  • [ISSN] 1573-7225
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Flavonoids; 0 / Proanthocyanidins
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8. Agkoc M, Dursun H, Albayrak F, Yilmaz O, Kiziltunc A, Yilmaz A, Gundogdu C: Usefulness of serum pepsinogen levels as a screening test for atrophic gastritis and gastric cancer. Eurasian J Med; 2010 Apr;42(1):15-8
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  • [Title] Usefulness of serum pepsinogen levels as a screening test for atrophic gastritis and gastric cancer.
  • OBJECTIVE: The purpose of our study was to research the applicability of measuring serum pepsinogen I (PG I) and PG I/pepsinogen II (PG II) ratios as screening tests for atrophic gastritis, which is the most important predisposition for stomach cancer.
  • MATERIALS AND METHODS: We measured serum pepsinogen levels in non-specific gastritis, atrophic gastritis and gastric cancer using a radioimmunoassay method.
  • We included in this study 30 healthy control, 30 nonspecific gastritis, 30 atrophic gastritis and 50 gastric cancer cases.
  • RESULTS: The serum PG I level was statistically higher in the control group and in the patient group with chronic nonspecific gastritis compared to the patient groups with chronic atrophic gastritis and stomach cancer (p<0.05).
  • The best cutoff values for diagnosing stomach cancer using serum PG I and PG I / PG II ratios were found to be <25 ng/ml for PG I and <3.0 for PG I / PG II.
  • CONCLUSIONS: Serum pepsinogen screening was shown to be a practical predictor of stomach cancer and atrophic gastritis, the most important predisposing lesion for stomach cancer.
  • Although the diagnosis of stomach cancers localized in the pylorus and cardia via this method is difficult, we believe that the detection of early-stage cancers that develop following chronic atrophic gastritis in particular will be possible, and therefore the morbidity and mortality of stomach cancer will be decreased.

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  • (PMID = 25610111.001).
  • [ISSN] 1308-8734
  • [Journal-full-title] The Eurasian journal of medicine
  • [ISO-abbreviation] Eurasian J Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Other-IDs] NLM/ PMC4261308
  • [Keywords] NOTNLM ; Gastritis / Pepsinogen / Stomach cancer
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9. Hocke M, Schöne U, Richert H, Görnert P, Keller J, Layer P, Stallmach A: Every slow-wave impulse is associated with motor activity of the human stomach. Am J Physiol Gastrointest Liver Physiol; 2009 Apr;296(4):G709-16
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  • [Title] Every slow-wave impulse is associated with motor activity of the human stomach.
  • Using a newly developed high-resolution three-dimensional magnetic detector system (3D-MAGMA), we observed periodical movements of a small magnetic marker in the human stomach at the typical gastric slow-wave frequency, that is 3 min(-1).
  • Thus we hypothesized that each gastric slow wave induces a motor response that is not strong enough to be detected by conventional methods.
  • Electrogastrographies (EGG, Medtronic, Minneapolis, MN) for measurement of gastric slow waves and 3D-MAGMA (Innovent, Jena, Germany) measurements were simultaneously performed in 21 healthy volunteers (10 men, 40.4+/-13.6 yr; 11 women, 35.8+/-11.6 yr).
  • Gastric transit time of the magnetic marker ranged from 19 to 154 min.
  • The mean dominant EGG frequency while the marker was in the stomach was 2.87+/-0.15 cpm.
  • Our findings suggest that each gastric slow wave induces a minute contraction that is too small to be detected by conventional motility investigations but can be recorded by the 3D-MAGMA system.
  • [MeSH-major] Gastrointestinal Motility / physiology. Muscle Contraction / physiology. Muscle, Smooth / physiology. Stomach / physiology

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  • (PMID = 19095766.001).
  • [ISSN] 0193-1857
  • [Journal-full-title] American journal of physiology. Gastrointestinal and liver physiology
  • [ISO-abbreviation] Am. J. Physiol. Gastrointest. Liver Physiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Zugor V, Schreiber M, Klein P, Schott GE: [Urinary bladder augmentation using the stomach in patients with compensated renal insufficiency]. Urologe A; 2007 Jun;46(6):667-70
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  • [Title] [Urinary bladder augmentation using the stomach in patients with compensated renal insufficiency].
  • [Transliterated title] Harnblasenaugmentation mit Magen bei kompensierter Niereninsuffizienz.
  • This case report describes a female patient with bladder exstrophy and chronic compensated renal insufficiency as it relates to the topic of urinary bladder augmentation using the stomach and cutaneous vesicostomy with a Mitrofanoff continent stoma.
  • There have as yet been no reports of malignant degeneration inside the gastric portion used for augmentation or the urothelium exposed to stomach acid.
  • [MeSH-major] Bladder Exstrophy / surgery. Kidney Failure, Chronic / surgery. Postoperative Complications / surgery. Stomach / transplantation. Urinary Bladder / surgery. Urinary Reservoirs, Continent


11. Pech O, Günter E, Ell C: [Endosonography of the esophagus and stomach]. Z Gastroenterol; 2008 Jun;46(6):564-71
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  • [Title] [Endosonography of the esophagus and stomach].
  • [Transliterated title] Endosonografie Osophagus und Magen.
  • Endosonography is considered to be the most exact method for the staging of carcionomas of the oesophagus and stomach.
  • It enables a differentiation of the T stages of carcinomas of the oesophagus and stomach with an accuracy of between 65 and 90 %.
  • [MeSH-major] Endosonography / methods. Esophageal Neoplasms / ultrasonography. Lymphatic Metastasis / ultrasonography. Stomach Neoplasms / ultrasonography
  • [MeSH-minor] Barrett Esophagus / pathology. Barrett Esophagus / ultrasonography. Biopsy. Humans. Neoplasm Staging. Precancerous Conditions / pathology. Precancerous Conditions / ultrasonography. Sensitivity and Specificity

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  • (PMID = 18537084.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 15
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12. Toffoli G, Cecchin E: Pharmacogenetics and stomach cancer: an update. Pharmacogenomics; 2007 May;8(5):497-505
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  • [Title] Pharmacogenetics and stomach cancer: an update.
  • Although new drugs and association regimens have been used in recent years, the chemotherapeutic outcome for gastric cancer is still poor and improvement in patient survival is not satisfactory.
  • The most recent update regarding gastric cancer pharmacogenetics highlights a prominent role of genetic polymorphisms of thymidylate synthase and glutathione S-transferase in the pharmacological treatment with commonly used drugs, such as 5-fluorouracil and platinum derivatives.
  • A future challenge is represented by the introduction of targeted therapy in gastric cancer treatment, with the potential emerging tool of pharmacogenetic impact on this field.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols. Pharmacogenetics. Polymorphism, Genetic. Stomach Neoplasms / drug therapy. Stomach Neoplasms / genetics

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  • (PMID = 17465714.001).
  • [ISSN] 1744-8042
  • [Journal-full-title] Pharmacogenomics
  • [ISO-abbreviation] Pharmacogenomics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.1.1.45 / Thymidylate Synthase; EC 2.5.1.18 / Glutathione Transferase
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13. Hahm MI, Choi KS, Kye SY, Kwak MS, Park EC: [Factors influencing the intention to have stomach cancer screening]. J Prev Med Public Health; 2007 May;40(3):205-12
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  • [Title] [Factors influencing the intention to have stomach cancer screening].
  • OBJECTIVES: The purpose of this study was to identify the factors influencing the intention to have stomach cancer screening using the theory of planned behavior (TPB) in Korea.
  • Multiple linear regression was used to identify the factors influencing the intention to have stomach cancer screening.
  • RESULTS: Perceived behavioral control and attitude toward stomach cancer screening were significant predictors of the intention to have stomach cancer screening.
  • However, subjective norm only influenced the intention to have stomach cancer screening with full charge in the next two years.
  • CONCLUSIONS: The results suggest that attitude and perceived behavioral control are likely to contribute toward increasing the intention to have stomach cancer screening.
  • [MeSH-major] Patient Acceptance of Health Care. Stomach Neoplasms / diagnosis

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  • (PMID = 17577075.001).
  • [ISSN] 1975-8375
  • [Journal-full-title] Journal of preventive medicine and public health = Yebang Ŭihakhoe chi
  • [ISO-abbreviation] J Prev Med Public Health
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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14. Antao B, Foxall G, Guzik I, Vaughan R, Roberts JP: Foreign body ingestion causing gastric and diaphragmatic perforation in a child. Pediatr Surg Int; 2005 Apr;21(4):326-8
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  • [Title] Foreign body ingestion causing gastric and diaphragmatic perforation in a child.
  • Most ingested foreign bodies pass through the gastrointestinal tract without difficulty once they reach the stomach.
  • This case report discusses the clinical presentation and management of a very unusual case of an eyeliner pencil ingested by a child that perforated the stomach and diaphragm, causing empyema.
  • [MeSH-major] Diaphragm / injuries. Foreign Bodies / complications. Stomach / injuries

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  • (PMID = 15645252.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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15. Lorentzen T, Nolsøe CP, Adamsen S: Percutaneous radiologic gastrostomy with a simplified gastropexy technique under ultrasonographic and fluoroscopic guidance: experience in 154 patients. Acta Radiol; 2007 Feb;48(1):13-9
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  • Initially, the stomach was filled with 300-500 cm3 of tap water via a nasogastric tube.
  • The fluid-filled stomach was punctured under US guidance.
  • During dilatation, the external suture string to the T-fastener was held tight to fixate the gastric wall.
  • The T-fastener was then released, and the gastrostomy tube was retracted gently to affix the gastric wall to the abdominal wall (tube gastropexy).
  • Technical success was assured by aspiration of gastric fluid and fluoroscopically by injection of a water-soluble contrast medium.
  • CONCLUSION: PRG guided by US and fluoroscopy is a relatively safe technique with a high success rate, provided the stomach can be properly distended with fluid.
  • [MeSH-major] Gastrostomy / methods. Radiography, Interventional / methods. Stomach / surgery. Stomach / ultrasonography. Ultrasonography, Interventional / methods

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  • (PMID = 17325919.001).
  • [ISSN] 0284-1851
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 059QF0KO0R / Water
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16. Keith JD, Pacey GE, Cotruvo JA, Gordon G: Experimental results from the reaction of bromate ion with synthetic and real gastric juices. Toxicology; 2006 Apr 17;221(2-3):225-8
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  • [Title] Experimental results from the reaction of bromate ion with synthetic and real gastric juices.
  • This study was designed to identify and quantify the effects of reducing agents on the rate of bromate ion reduction in real and synthetic gastric juice.
  • Synthetic gastric juice containing H+ and Cl- did exhibit reduced bromate ion levels, but at a rate that was too slow for a significant amount of bromate to be reduced under typical stomach retention time conditions.
  • Addition of the reducing agents hydrogen sulfide (which was shown to be present and quantified in real gastric juice), glutathione, and/or cysteine increased the rate of bromate ion loss.
  • Therefore, the lifetime of bromate ion in solutions containing typical gastric juice concentrations of H+, Cl-, and H2S is 20-30 min.
  • This rate should result in as much as a 99% reduction of bromate ion during its residence in the stomach.
  • Bromate ion reduction in real gastric juice occurred at a rapid rate.
  • A comparison of real and synthetic gastric juice containing H+, Cl-, cysteine, glutathione, and hydrogen sulfide showed that the component most responsible for the considerable decrease of the concentration of bromate ion in the stomach is hydrogen sulfide.
  • [MeSH-major] Bromates / chemistry. Gastric Juice / chemistry. Models, Biological. Water Supply / standards

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  • (PMID = 16530909.001).
  • [ISSN] 0300-483X
  • [Journal-full-title] Toxicology
  • [ISO-abbreviation] Toxicology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Bromates; 0 / Sulfur Compounds; 4R7X1O2820 / Chlorine; 712K4CDC10 / Hypochlorous Acid; GAN16C9B8O / Glutathione; K848JZ4886 / Cysteine
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17. Shibahara H, Arai T, Yokoi S, Hayakawa S: Bronchogenic cyst of the stomach involved with gastric adenocarcinoma. Clin J Gastroenterol; 2009 Apr;2(2):80-84
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  • [Title] Bronchogenic cyst of the stomach involved with gastric adenocarcinoma.
  • Bronchogenic cyst, a congenital anomaly mostly found in the mediastinum, rarely arises in the stomach.
  • A 43-year-old man had epigastric pain and was diagnosed as having gastric adenocarcinoma.
  • Abdominal ultrasonography showed hepatic cyst, and computed tomography and magnetic resonance imaging revealed a cystic lesion near the stomach.
  • At surgery, the cystic lesion was found to be located at the lesser curvature of the stomach where the cancer invasion was seen.
  • The pathological diagnosis was bronchogenic cyst of the stomach involved with gastric adenocarcinoma.
  • Based on a similar association between gastric diffuse submucosal cysts and gastric cancer in the previous reports, it is possible that chronic inflammation from bronchogenic cysts to the gastric mucosa may cause adenocarcinoma in the stomach.
  • At surgery, complete combined resection without rupture of the bronchogenic cyst involved with the gastric adenocarcinoma is needed for treatment of gastric cancer to prevent dissemination of cancer cells considering when cancer cells have invaded beyond the pseudostratified ciliated columnar epithelium and within the bronchogenic cyst.

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  • (PMID = 26192170.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Adenocarcinoma / Bronchogenic cyst / Stomach
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18. Kuzuhara T, Suganuma M, Kurusu M, Fujiki H: Helicobacter pylori-secreting protein Tipalpha is a potent inducer of chemokine gene expressions in stomach cancer cells. J Cancer Res Clin Oncol; 2007 May;133(5):287-96
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  • [Title] Helicobacter pylori-secreting protein Tipalpha is a potent inducer of chemokine gene expressions in stomach cancer cells.
  • PURPOSE: Stomach cancer has a high mortality rate in East Asia, and is strongly associated with Helicobacter pylori (H. pylori) infection. H. pylori is known to express chemokine genes in the gastric mucosa, chemokines that are important host immune factors facilitating inflammation and tumor growth.
  • To investigate the mechanism of carcinogenesis in the stomach, it is essential to determine which molecule of H. pylori is involved in induction of chemokines, but this has remained unclear.
  • We previously reported that a tumor necrosis factor-alpha (TNF-alpha) inducing protein (Tipalpha) secreted from H. pylori acts as a tumor promoter in stomach cancer development, and thus started to investigate whether Tipalpha is involved in induction of chemokine genes.
  • RESULTS: Comprehensive and quantitative gene expression analyses revealed that Tipalpha induces gene expression of the chemokines Ccl2, Ccl7, Ccl20, Cxcl1, Cxcl2, Cxcl5 and Cxcl10 extensively and simultaneously in mouse stomach cancer cells, MGT-40.
  • Tipalpha induced high levels of chemokine gene expression, whereas inactive deleted Tipalpha, del-Tipalpha, showed only marginal expression, suggesting a correlation between tumor promotion and chemokine gene expression by Tipalpha.
  • CONCLUSION: We report here that Tipalpha of H. pylori gene product is a strong inducer of chemokine gene expressions, providing a new model for stomach cancer development.
  • [MeSH-major] Bacterial Proteins / pharmacology. Chemokines / genetics. Gene Expression Regulation, Neoplastic. Helicobacter pylori / metabolism. Stomach Neoplasms / etiology

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  • (PMID = 17393199.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Chemokines; 0 / Tipalpha protein, Helicobacter pylori
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19. Sakai Y, Kinoshita H, Saitou K, Homma I, Nobe K, Iwamoto T: Functional differences of Na+/Ca2+ exchanger expression in Ca2+ transport system of smooth muscle of guinea pig stomach. Can J Physiol Pharmacol; 2005 Aug-Sep;83(8-9):791-7
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  • [Title] Functional differences of Na+/Ca2+ exchanger expression in Ca2+ transport system of smooth muscle of guinea pig stomach.
  • However, little is known regarding distribution and function of the NCX in guinea pig gastric smooth muscle.
  • Western blotting analysis revealed that NCX1 and NCX2 are the predominant NCX isoforms expressed in stomach, the former was expressed strongly in antrum, whereas the latter displayed greater expression in fundus.
  • Isolated plasma membrane fractions derived from gastric fundus smooth muscle were also investigated to clarify the relationship between NCX protein expression and function.
  • Results documented evidence that NCX2 isoform functionally contributes to Ca2+ extrusion and maintenance of contraction-relaxation cycle in gastric fundus smooth muscle.
  • [MeSH-major] Calcium / metabolism. Gastric Fundus / metabolism. Muscle, Smooth / metabolism. Pyloric Antrum / metabolism. Sodium-Calcium Exchanger / metabolism

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  • (PMID = 16333381.001).
  • [ISSN] 0008-4212
  • [Journal-full-title] Canadian journal of physiology and pharmacology
  • [ISO-abbreviation] Can. J. Physiol. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate; 0 / Sodium-Calcium Exchanger; 0 / sodium-calcium exchanger 1; 8Y164V895Y / Carbachol; GYV9AM2QAG / Thiourea; SY7Q814VUP / Calcium
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20. Madison BB, McKenna LB, Dolson D, Epstein DJ, Kaestner KH: FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine. J Biol Chem; 2009 Feb 27;284(9):5936-44
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  • [Title] FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine.

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  • (PMID = 19049965.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / P30 DK050306; United States / NIDDK NIH HHS / DK / DK-050306; United States / NIDDK NIH HHS / DK / DK-053839
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Forkhead Transcription Factors; 0 / Foxf1a protein, mouse; 0 / Foxl1 protein, mouse; 0 / Gli2 protein; 0 / Gli3 protein, mouse; 0 / Hedgehog Proteins; 0 / Kruppel-Like Transcription Factors; 0 / Nerve Tissue Proteins; 0 / RNA, Messenger; 0 / Shh protein, mouse; EC 1.13.12.- / Luciferases
  • [Other-IDs] NLM/ PMC2645837
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21. Klingensmith WC 3rd, Lawrence SP: The gastric emptying study: protocol design considerations. J Nucl Med Technol; 2008 Dec;36(4):195-9
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  • [Title] The gastric emptying study: protocol design considerations.
  • This study evaluated the intrapatient correlation for gastric emptying times with instant oatmeal and scrambled egg meals.
  • In addition, this study evaluated the degree of overlap between the stomach and the colon or jejunum in the anterior (AP) and left anterior oblique (LAO) projections in CT studies of the abdomen.
  • In addition, the degree of overlap between the stomach and the colon or jejunum in the AP and LAO projections in 100 CT studies of the abdomen was categorized as none, mild (up to 25%), moderate (25%-50%), or marked (>50%).
  • RESULTS: One pair of gastric emptying studies was eliminated as an outlier because the distribution of the meals in the stomach, as determined by imaging, was very different for the 2 studies.
  • The stomach overlapped the colon 74% of the time in the AP projection and 82% of the time in the LAO projection (P = not significant).
  • The stomach overlapped the jejunum 77% of the time in the AP projection but only 52% of the time in the LAO projection (P < 0.05).
  • CONCLUSION: The significant correlation between the instant oatmeal and scrambled egg gastric emptying times suggests that similar information is provided by the 2 meals.
  • The frequent overlap of the stomach and the colon in both the AP and the LAO projections suggests that imaging at delayed times, such as 4 h, is likely to be problematic because of colonic activity within the stomach region of interest.
  • In addition, the frequent overlap of the stomach and the jejunum has implications for calculation of the lag time; the less frequent overlap of the stomach and the jejunum in the LAO projection than in the AP projection may be an advantage for imaging in the LAO projection.
  • [MeSH-major] Gastric Emptying. Image Enhancement / methods. Radionuclide Imaging / methods. Stomach / radionuclide imaging. Technetium Tc 99m Sulfur Colloid

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  • (PMID = 19008283.001).
  • [ISSN] 0091-4916
  • [Journal-full-title] Journal of nuclear medicine technology
  • [ISO-abbreviation] J Nucl Med Technol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 556Q0P6PB1 / Technetium Tc 99m Sulfur Colloid
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22. Kim TO, Kang DH, Kim GH, Heo J, Song GA, Cho M, Kim DH, Sim MS: Self-expandable metallic stents for palliation of patients with malignant gastric outlet obstruction caused by stomach cancer. World J Gastroenterol; 2007 Feb 14;13(6):916-20
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  • [Title] Self-expandable metallic stents for palliation of patients with malignant gastric outlet obstruction caused by stomach cancer.
  • METHODS: A retrospective review was performed throughout August 2000 to June 2005 of 53 patients with gastric outlet obstruction caused by stomach cancer.
  • Seventeen patients had recurrent obstruction (tumor ingrowth in 14 patients, tumor overgrowth in 1 patient, and partial distal stent migration in 2 patients).
  • CONCLUSION: Endoscopic placement of self-expandable metallic stents is a safe and effective treatment for the palliation of patients with inoperable malignant gastric outlet obstruction caused by stomach cancer.
  • [MeSH-major] Gastric Outlet Obstruction / etiology. Gastric Outlet Obstruction / surgery. Palliative Care / methods. Stents. Stomach Neoplasms / complications

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  • (PMID = 17352023.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4065929
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23. Doğan A, Kolankaya D: Protective effect of Anzer honey against ethanol-induced increased vascular permeability in the rat stomach. Exp Toxicol Pathol; 2005 Nov;57(2):173-8
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  • [Title] Protective effect of Anzer honey against ethanol-induced increased vascular permeability in the rat stomach.
  • Evan's Blue (EB) dye, administered intracardiacly and extravasation of EB into the stomach, served as an indicator of vascular permeability following exposure to alcohol.
  • Ethanol was given orally to the ethanol group for 90 days, and N-etylmaleimide (NEM) was given subcutaneously to the NEM group, and we observed increased extravasation of EB in the stomach in both groups.
  • The mean amount of EB that leaked into the stomach of rats in the ethanol group and the NEM group was higher than that of the control group.
  • Histopathologically, the incidence and severity of gastric mucosal congestion were significantly reduced in the honey+ethanol group when compared to the ethanol group.
  • These result indicate that Anzer honey is able to protect the stomach of the rat against ethanol-induced increased vascular permeability, which may be correlated with the ascorbic acid content.
  • [MeSH-major] Capillary Permeability / drug effects. Ethanol / toxicity. Gastric Mucosa / drug effects. Honey

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  • (PMID = 16325527.001).
  • [ISSN] 0940-2993
  • [Journal-full-title] Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie
  • [ISO-abbreviation] Exp. Toxicol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 3K9958V90M / Ethanol
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24. Holstein B, Andersen A, Due P, Hansen EH: [Children's and adolescent's use of medicine for aches and psychological problems: secular trends from 1988 to 2006]. Ugeskr Laeger; 2009 Jan 5;171(1-2):24-8
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  • The objective of this paper is to describe self-reported medicine use for headaches, stomach-aches, difficulties in falling asleep, and nervousness among 11-, 13-, and 15-year-old boys and girls from 1968 to 2006.
  • The proportion who used medicine for stomach-aches increased from 7.5% in 1988 to 16.2% in 2002 and 15.2% in 2006.
  • In the same period, the proportion who reported headaches and stomach-aches within the previous month decreased.
  • [MeSH-minor] Adolescent. Child. Cross-Sectional Studies. Drug Utilization. Female. Headache / drug therapy. Humans. Male. Sleep Initiation and Maintenance Disorders / drug therapy. Stomach Diseases / drug therapy

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  • [CommentIn] Ugeskr Laeger. 2009 Jan 5;171(1-2):23 [19128559.001]
  • (PMID = 19128560.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Analgesics; 0 / Central Nervous System Agents; 0 / Psychotropic Drugs
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25. Eder E, Wacker M, Wanek P: Lipid peroxidation-related 1,N2-propanodeoxyguanosine-DNA adducts induced by endogenously formed 4-hydroxy-2-nonenal in organs of female rats fed diets supplemented with sunflower, rapeseed, olive or coconut oil. Mutat Res; 2008 Jul 31;654(2):101-7
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  • We investigated the role of supplementation of the diet of female F344-rats with sunflower, rapeseed, olive or coconut oil on the formation of the promutagenic, exocyclic 1,N2-propanodeoxyguanosine adduct of the main lipid peroxidation product 4-hydroxy-2-nonenal in the mucosa of the glandular stomach, the small intestine, the colon, the whole kidney and the lung.
  • Inverse relationships between linoleic acid, PUFA and vitamin E intake and adduct levels were found in the glandular stomach and the lung.
  • Saturated fatty acids showed a significant positive correlation with adduct levels in the mucosa of the glandular stomach and a significant inverse correlation in the small intestine.
  • [MeSH-minor] Animals. Brassica rapa / chemistry. Colon / metabolism. Female. Helianthus / chemistry. Intestine, Small / metabolism. Kidney / metabolism. Linoleic Acid / pharmacology. Lung / metabolism. Olive Oil. Rats. Rats, Inbred F344. Stomach / metabolism. Vitamin E

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  • (PMID = 18602860.001).
  • [ISSN] 0027-5107
  • [Journal-full-title] Mutation research
  • [ISO-abbreviation] Mutat. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / 1,N(2)-(1,3-propano)-2'-deoxyguanosine; 0 / Aldehydes; 0 / DNA Adducts; 0 / Olive Oil; 0 / Plant Oils; 1406-18-4 / Vitamin E; 29343-52-0 / 4-hydroxy-2-nonenal; 8001-31-8 / coconut oil; 9KJL21T0QJ / Linoleic Acid; G9481N71RO / Deoxyguanosine
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26. Arena F, Romeo C, Baldari S, Arena S, Antonuccio P, Campennì A, Zuccarello B, Romeo G: Gastrointestinal sequelae in survivors of congenital diaphragmatic hernia. Pediatr Int; 2008 Feb;50(1):76-80
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  • Patients underwent physical examination, barium meal study, gastroesophageal scintigraphy, esophageal pH monitoring and manometry of the esophagus and stomach.
  • In 41.7% of group A and 47% of group B the time taken for the stomach to empty half of its radioactive content (T(1/2)) was pathological.
  • In 36.4% of group A and 46.7% of group B alteration of peristalsis of the stomach was recorded.


27. Foryś S, Rudnicki C, Walecka-Kapica E, Chojnacki J: [Electrogastrography in various clinical forms of functional dyspepsia]. Pol Merkur Lekarski; 2009 May;26(155):373-7
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  • Electrogastrography (EGG) is simple, noninvasive, painless and repeatable method of assessment of gastric myoelectrical activity.
  • By means of cutaneous electrodes placed on the abdomen skin we can record and then using computer evaluate the slow waves of the stomach and this is one of the methods for the assessment of gastric myoelectrical activity that makes its possible to draw inferences about gastric motility.
  • The pathogenesis of functional dyspepsia is still not clear, but the disorders of the motility and myoelectrical activity of the stomach probably play here very important role.
  • AIM OF OUR STUDY: To evaluate gastric myoelectrical activity in patients suffering from functional dyspepsia (FD) and to answer the question if there are some differences between two clinical forms of the functional dyspepsia.
  • After an hour of recording of the gastric myoelectrical activity in patients on an empty stomach a solid or liquid test meal was served.
  • RESULTS: In the patients with functional dyspepsia gastric myoelectrical disorders occur with dominating dysrhythmia (p < 0.001), especially bradygastria, both in the record on an empty stomach and after a meal.
  • CONCLUSIONS. (1) In the patients with functional dyspepsia gastric myoelectrical disorders occur with dominating dysrhythmia, especially bradygastria. (2) The EGG records are different in the two clinical forms of dyspepsia and this may be used for differential diagnostics of this disease: in epigastric pain syndrome bradygastria prevails whereas in postprandial distress syndrome bradygastria is dominant and an essential proportion of tachygastria is observed.
  • [MeSH-major] Dyspepsia / diagnosis. Electrodiagnosis / methods. Stomach / physiopathology
  • [MeSH-minor] Adult. Aged. Electromyography. Female. Gastric Emptying. Gastrointestinal Motility. Humans. Male. Middle Aged. Young Adult

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  • (PMID = 19606677.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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28. Khan MI, Baqai MT, Baqai MF, Mufti N: Exsanguinating upper GI bleeds due to Unusual Arteriovenous Malformation (AVM) of stomach and spleen: a case report. World J Emerg Surg; 2009;4:15
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  • [Title] Exsanguinating upper GI bleeds due to Unusual Arteriovenous Malformation (AVM) of stomach and spleen: a case report.
  • It revealed gastric ulcer just distal to the gastro-esophageal junction on the lesser curvature.

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  • [ISSN] 1749-7922
  • [Journal-full-title] World journal of emergency surgery : WJES
  • [ISO-abbreviation] World J Emerg Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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29. Chen CY, Inui A, Asakawa A, Fujino K, Kato I, Chen CC, Ueno N, Fujimiya M: Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats. Gastroenterology; 2005 Jul;129(1):8-25
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  • [Title] Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats.
  • BACKGROUND & AIMS: Although it has been shown that des-acyl ghrelin decreases food intake and gastric emptying, no previous studies have examined the effects of des-acyl ghrelin on physiologic fed and fasted motor activity in the gastrointestinal tract.
  • METHODS: We examined the effects of intraperitoneal (IP) administration of des-acyl ghrelin on food intake and the effects of intracerebroventricular (ICV) or intravenous (IV) administration of des-acyl ghrelin on gastroduodenal motility using freely moving conscious rat models.
  • RESULTS: IP injection of des-acyl ghrelin decreased food intake, and this effect was not altered by capsaicin treatment.
  • IP injection of des-acyl ghrelin enhanced c- fos expression in the arcuate and paraventricular nucleus but not in the nucleus of the solitary tract.
  • Both ICV and IV injection of des-acyl ghrelin disrupted fasted motor activity in the antrum but not in the duodenum.
  • Changes in gastric motility induced by IV injection of des-acyl ghrelin were completely antagonized by ICV injection of a selective corticotropin-releasing factor (CRF) 2 receptor antagonist; however, the CRF 1 receptor antagonist had no effects.
  • CONCLUSIONS: The results suggest that des-acyl ghrelin decreases food intake and disrupts the fasted motor activity of the antrum in freely moving conscious rats.
  • Peripheral des-acyl ghrelin may induce this function by direct activation of brain receptor by crossing the blood-brain barrier but not by the activation of vagal afferent pathways.
  • [MeSH-major] Gastric Emptying / drug effects. Peptide Hormones / metabolism. Peptide Hormones / pharmacology. Receptors, Corticotropin-Releasing Hormone / metabolism

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  • (PMID = 16012930.001).
  • [ISSN] 0016-5085
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine; 0 / Aniline Compounds; 0 / CRF receptor type 1; 0 / CRF receptor type 2; 0 / Ghrelin; 0 / Neuroprotective Agents; 0 / Peptide Fragments; 0 / Peptide Hormones; 0 / Proto-Oncogene Proteins c-fos; 0 / Pyrimidines; 0 / Receptors, Corticotropin-Releasing Hormone; 0 / antisauvagine 30; 0 / ghrelin, des-n-octanoyl; 170809-51-5 / astressin; 9015-71-8 / Corticotropin-Releasing Hormone; S07O44R1ZM / Capsaicin
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30. Ebrahimi K, Velicković D, Spica B, Sabljak P, Bjelović M, Stojakov D, Micev M, Dunjić M, Pesko P: [Gastrointestinal stromal tumors (GIST) of the stomach as a cause of upper gastrointestinal bleeding]. Acta Chir Iugosl; 2007;54(1):115-8
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  • [Title] [Gastrointestinal stromal tumors (GIST) of the stomach as a cause of upper gastrointestinal bleeding].
  • Gastrointestinal stromal tumors (GIST) is the most common mesenchymal tumor of the gastrointestinal tract.
  • GIST is currently defined as a gastrointestinal tract mesenchymal tumor containing spindle cells (less commonly epitheloid cells or rarely both) and showing CD 117 (c-kit protein) positivity in more than 95% of cases.
  • Although they may arise throughout the gut, the commonest site are stomach (60-70%), small intestine (20-30%), colorectum (5%) and esophagus (up to 5%).
  • Subsequently, it has been determined that GISTs have distinct ultrastructural features and immunophenotypical markers compared with smooth muscle and smooth muscle tumors.
  • Clinical presentation of GIST varies widely, and depends on tumor size and location.
  • Commonest symptom of gastric GIST is manifest or occult bleeding.
  • [MeSH-major] Gastrointestinal Hemorrhage / etiology. Gastrointestinal Stromal Tumors / complications. Stomach Neoplasms / complications


31. Liu TY, Dei PH, Kuo SH, Lin CW: Early low-grade gastric MALToma rarely transforms into diffuse large cell lymphoma or progresses beyond the stomach and regional lymph nodes. J Formos Med Assoc; 2010 Jun;109(6):463-71
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  • [Title] Early low-grade gastric MALToma rarely transforms into diffuse large cell lymphoma or progresses beyond the stomach and regional lymph nodes.
  • BACKGROUND/PURPOSE: Gastric mucosa-associated lymphoid tissue lymphoma (MALToma) usually presents at an early stage involving only the stomach and/or regional lymph nodes.
  • Although a sequential transformation from low-grade gastric MALToma (GM) to high-grade GM to secondary diffuse large B-cell lymphoma (DLBCL) is commonly assumed, documented cases of transformation are rare.
  • RESULTS: We found that only one early low-grade GM and two early high-grade GMs transformed into secondary DLBCLs and progressed outside the stomach and regional lymph nodes.
  • CONCLUSION: Compared with chronic lymphocytic leukemia, which has a 16% transformation rate and a median transformation time of 24 months, we conclude that early low-grade GM rarely transforms into secondary DLBCL or progresses beyond the stomach.

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  • [Copyright] Copyright (c) 2010 Formosan Medical Association & Elsevier. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20610148.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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32. Hong KP, Lee SJ, Hong GS, Yoon H, Shim BS: Prostate cancer metastasis to the stomach. Korean J Urol; 2010 Jun;51(6):431-3
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  • [Title] Prostate cancer metastasis to the stomach.
  • However, stomach metastasis related to prostate cancer is rare.
  • Here, we report a case of prostate cancer metastatic to the stomach.
  • He was noted as having abdominal discomfort, nausea, and vomiting 18 months after the diagnosis.
  • A histopathologic examination and an esophagogastroduodenoscopic gastric biopsy revealed stomach-metastatic adenocarcinoma.
  • The patient died of cardiovascular complications 5 months after the diagnosis of stomach metastasis.

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33. Combet E, Paterson S, Iijima K, Winter J, Mullen W, Crozier A, Preston T, McColl KE: Fat transforms ascorbic acid from inhibiting to promoting acid-catalysed N-nitrosation. Gut; 2007 Dec;56(12):1678-84
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  • BACKGROUND: The major potential site of acid nitrosation is the proximal stomach, an anatomical site prone to a rising incidence of metaplasia and adenocarcinoma.
  • Nitrite, a pre-carcinogen present in saliva, can be converted to nitrosating species and N-nitroso compounds by acidification at low gastric pH in the presence of thiocyanate.
  • AIMS: To assess the effect of lipid and ascorbic acid on the nitrosative chemistry under conditions simulating the human proximal stomach.
  • METHODS: The nitrosative chemistry was modelled in vitro by measuring the nitrosation of four secondary amines under conditions simulating the proximal stomach.

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  • (PMID = 17785370.001).
  • [ISSN] 1468-3288
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Lipids; 0 / Nitrosamines; 31C4KY9ESH / Nitric Oxide; PQ6CK8PD0R / Ascorbic Acid; QTT17582CB / Hydrochloric Acid; S88TT14065 / Oxygen
  • [Other-IDs] NLM/ PMC2095705
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34. Gulmann C, Lantuejoul S, Grace A, Leader M, Patchett S, Kay E: Telomerase activity in proximal and distal gastric neoplastic and preneoplastic lesions using immunohistochemical detection of hTERT. Dig Liver Dis; 2005 Jun;37(6):439-45
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  • [Title] Telomerase activity in proximal and distal gastric neoplastic and preneoplastic lesions using immunohistochemical detection of hTERT.
  • BACKGROUND: The incidence of distal (corpus and antrum) gastric adenocarcinoma is decreasing with a simultaneous increase in incidence of proximal (cardia) adenocarcinoma.
  • Intestinal metaplasia may have a lower malignant potential in the proximal stomach but regardless of the locations, its specificity as a predictor of carcinoma is low.
  • AIMS: The aim of this study was to establish whether human telomerase reverse transcriptase expression differs at various points in proximal versus distal gastric carcinogenesis and to test the utility of human telomerase reverse transcriptase expression as a marker of cancer risk in intestinal metaplasia.
  • MATERIAL AND METHODS: Wax-embedded tissue from proximal and distal stomach including normal mucosa (n=86), intestinal metaplasia (n=83) and carcinoma (n=101) were used and slides were immunostained for human telomerase reverse transcriptase and pRb and scored semi-quantitatively.
  • RESULTS: The results showed that in both proximal and distal stomach, human telomerase reverse transcriptase expression rates increased from normal mucosa to cancer.
  • CONCLUSIONS: In conclusion, telomerase activity appears to be an early event in both proximal and distal gastric carcinogenesis and human telomerase reverse transcriptase is expressed in intestinal metaplasia.
  • [MeSH-major] Carcinoma / metabolism. DNA-Binding Proteins / metabolism. Precancerous Conditions / metabolism. Stomach Neoplasms / metabolism. Telomerase / metabolism
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Female. Humans. Immunohistochemistry. Intestinal Mucosa / metabolism. Intestines / metabolism. Intestines / pathology. Male. Metaplasia / metabolism. Middle Aged. Retinoblastoma Protein / metabolism

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  • (PMID = 15893283.001).
  • [ISSN] 1590-8658
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Retinoblastoma Protein; EC 2.7.7.49 / Telomerase
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35. Bernsand M, Zhao CM, Håkanson R, Stenström B, Chen D, Norlén P: Ischemia mobilizes histamine but not pancreastatin from ECL cells of rat stomach: evidence for a cytosolic histamine compartment. Cell Tissue Res; 2008 Sep;333(3):405-15
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  • [Title] Ischemia mobilizes histamine but not pancreastatin from ECL cells of rat stomach: evidence for a cytosolic histamine compartment.
  • Histamine in the rat stomach resides in enterochromaffin-like (ECL) cells and mast cells.
  • Ischemia (induced by clamping of the celiac artery or by gastric submucosal microinfusion of the vasoconstrictor endothelin) mobilizes large amounts of ECL-cell histamine in a burst-like manner.
  • Arterial clamping (30 min) and gastric submucosal microinfusion (3 h) of endothelin, vasopressin, or adrenaline caused ischemia, manifested as a raised lactate/pyruvate ratio and mucosal damage.
  • The long-term effects of ischemia and reperfusion (60-90 min) on gastric mucosa were examined in rats treated with the proton pump inhibitor omeprazole for 4 days.
  • [MeSH-major] Cell Compartmentation / physiology. Cytosol / metabolism. Enterochromaffin-like Cells / metabolism. Gastric Mucosa / metabolism. Histamine / metabolism. Ischemia / metabolism

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  • (PMID = 18592274.001).
  • [ISSN] 0302-766X
  • [Journal-full-title] Cell and tissue research
  • [ISO-abbreviation] Cell Tissue Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Endothelins; 0 / Gastrins; 0 / Pancreatic Hormones; 106477-83-2 / pancreastatin; 11000-17-2 / Vasopressins; 820484N8I3 / Histamine; YKH834O4BH / Epinephrine
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36. Murphy MC, Fox EA: Mice deficient in brain-derived neurotrophic factor have altered development of gastric vagal sensory innervation. J Comp Neurol; 2010 Aug 1;518(15):2934-51
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  • [Title] Mice deficient in brain-derived neurotrophic factor have altered development of gastric vagal sensory innervation.
  • Here, the contribution of brain-derived neurotrophic factor (BDNF) to survival and other aspects of gastric vagal afferent development was investigated.
  • Post-mortem anterograde tracing with 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbo-cyanine perchlorate (DiI) was used to label selectively vagal projections to the stomach on postnatal days (P) 0, 3, 4, and 6 in wild types and heterozygous or homozygous BDNF mutants.
  • Sampling sites distributed throughout the ventral stomach wall were scanned with a confocal microscope, and vagal axon bundles, single axons, putative mechanoreceptor precursors (intraganglionic laminar endings, IGLEs; intramuscular arrays, IMAs), and efferent terminals were quantified.
  • Quantitative comparisons across wild-type stomach compartments demonstrated that the adult distribution of IMAs was not present at P0 but began to form by P3-6.
  • The present results suggest that gastric IGLEs are among the vagal sensory neurons dependent on BDNF for survival or axon guidance.
  • Alternatively, BDNF deficiency may delay gastric IGLE development.

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  • [Copyright] (c) 2010 Wiley-Liss, Inc.
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  • (PMID = 20533354.001).
  • [ISSN] 1096-9861
  • [Journal-full-title] The Journal of comparative neurology
  • [ISO-abbreviation] J. Comp. Neurol.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS046716; United States / NINDS NIH HHS / NS / R01 NS046716-05; United States / NINDS NIH HHS / NS / NS046716
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Brain-Derived Neurotrophic Factor
  • [Other-IDs] NLM/ NIHMS205253; NLM/ PMC2888090
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37. Csendes A, Burgos AM, Smok G, Beltran M: Endoscopic and histologic findings of the foregut in 426 patients with morbid obesity. Obes Surg; 2007 Jan;17(1):28-34
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  • BACKGROUND: Roux-en-Y gastric bypass is the most frequent bariatric operation.
  • In this operation, the distal bypassed stomach is left in situ.
  • In the stomach, pathological findings were seen in 32% of the patients.
  • At the stomach, chronic inactive gastritis and atrophic gastritis with intestinal metaplasia were found in 8.6% and 6.5% respectively.
  • Antral adenoma with low-grade dysplasia was found in 1 patient, and 1 carcinoid tumor. H. pylori was present in 53% of the patients, mainly in the antrum.
  • [MeSH-major] Obesity, Morbid / pathology. Stomach / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Duodenum / pathology. Endoscopy. Esophagus / pathology. Female. Gastric Bypass. Humans. Intestinal Mucosa / pathology. Male. Middle Aged. Prospective Studies

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  • [CommentIn] Obes Surg. 2007 Jul;17(7):993; author reply 994 [17894165.001]
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  • (PMID = 17355765.001).
  • [ISSN] 0960-8923
  • [Journal-full-title] Obesity surgery
  • [ISO-abbreviation] Obes Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Williams AP, Avery LM, Killham K, Jones DL: Survival of Escherichia coli O157:H7 in the rhizosphere of maize grown in waste-amended soil. J Appl Microbiol; 2007 Feb;102(2):319-26
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  • AIMS: To assess whether the persistence of Escherichia coli O157:H7 in soil amended with cattle slurry and ovine stomach content waste is affected by the presence of a maize rhizosphere.
  • METHODS AND RESULTS: Cattle slurry and ovine stomach content waste were inoculated with E. coli O157:H7.
  • The pathogen survived in soil for over 5 weeks, although at significantly greater numbers in soil receiving stomach content waste in comparison to cattle slurry.

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  • (PMID = 17241336.001).
  • [ISSN] 1364-5072
  • [Journal-full-title] Journal of applied microbiology
  • [ISO-abbreviation] J. Appl. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Sewage
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39. Agale SV, Agale VG, Zode RR, Grover S, Joshi S: Heterotopic pancreas involving stomach and duodenum. J Assoc Physicians India; 2009 Sep;57:653-4
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  • [Title] Heterotopic pancreas involving stomach and duodenum.
  • Clinical diagnosis of malignancy was based on the findings of USG, CT scan and endoscopy.
  • [MeSH-major] Choristoma / diagnosis. Duodenal Diseases / diagnosis. Pancreas. Stomach Diseases / diagnosis

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  • (PMID = 20214004.001).
  • [ISSN] 0004-5772
  • [Journal-full-title] The Journal of the Association of Physicians of India
  • [ISO-abbreviation] J Assoc Physicians India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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40. Pacheco MA, Concepción JL, Rangel JD, Ruiz MC, Michelangeli F, Domínguez-Bello MG: Stomach lysozymes of the three-toed sloth (Bradypus variegatus), an arboreal folivore from the Neotropics. Comp Biochem Physiol A Mol Integr Physiol; 2007 Jul;147(3):808-19
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  • [Title] Stomach lysozymes of the three-toed sloth (Bradypus variegatus), an arboreal folivore from the Neotropics.
  • Lysozymes are antimicrobial defences that act as digestive enzymes when expressed in the stomach of herbivores with pre-gastric fermentation.
  • We studied this enzyme in the complex stomach of the three-toed sloth (Bradypus variegatus), a folivore with pre-gastric fermentation.
  • The optimal pHs were similar to the pH of the stomach portion where the enzymes were isolated.
  • We postulate that sloth stomach lysozymes may still be antimicrobial defences by protecting the microbial flora of the fermentation chamber against foreign bacteria.
  • [MeSH-major] Muramidase / metabolism. Sloths / metabolism. Stomach / enzymology. Tropical Climate

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  • (PMID = 16959513.001).
  • [ISSN] 1095-6433
  • [Journal-full-title] Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
  • [ISO-abbreviation] Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tissue Extracts; EC 3.2.1.17 / Muramidase
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41. Takeda K, Utsunomiya H, Kakiuchi S, Okuno Y, Oda K, Inada K, Tsutsumi Y, Tanaka T, Kakudo K: Citrus auraptene reduces Helicobacter pylori colonization of glandular stomach lesions in Mongolian gerbils. J Oleo Sci; 2007;56(5):253-60
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  • [Title] Citrus auraptene reduces Helicobacter pylori colonization of glandular stomach lesions in Mongolian gerbils.
  • We examined the efficacy of auraptene (AUR), an antioxidant agent of a citrus coumarin derivative, for suppressing gastric inflammation introduced by Helicobacter pylori (Hp) infection in Mongolian gerbils (MGs).
  • Real-time PCR was used to estimate the Hp population in glandular stomach lesions, and a histological assessment of inflammation was performed.
  • We conclude that dietary supplementation with 500 ppm of AUR suppresses Hp colonization, but does not reduce gastric inflammation.
  • [MeSH-major] Citrus / chemistry. Coumarins / pharmacology. Gerbillinae / microbiology. Helicobacter Infections / drug therapy. Helicobacter Infections / microbiology. Helicobacter pylori / drug effects. Stomach Diseases / drug therapy


42. Li AF, Li AC, Hsu CY, Li WY, Hsu HS, Chen JY: Small cell carcinomas in gastrointestinal tract: immunohistochemical and clinicopathological features. J Clin Pathol; 2010 Jul;63(7):620-5
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  • AIMS: To test the incidence of the expression of the immunohistochemical markers that aid diagnosis of gastrointestinal tract small cell carcinoma (GI-SmCC) and to evaluate the incidence of mixed endocrine-exocrine carcinomas in GI-SmCC.
  • The incidence of non-endocrine carcinoma component was evaluated in 42 GI-SmCCs (11 in the oesophagus, 15 in the stomach, 15 in the colon, and 1 in the small intestine).
  • Non-endocrine carcinoma components were demonstrated in 8 patients (4 in the oesophagus and 4 in the stomach).
  • Non-endocrine carcinoma components were demonstrated in about 30% of oesophagus and stomach SmCC; the neoplasms should be diagnosed as mixed endocrine-exocrine carcinoma.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Small Cell / metabolism. Gastrointestinal Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Esophageal Neoplasms / metabolism. Esophageal Neoplasms / pathology. Female. Humans. Male. Middle Aged. Mixed Tumor, Malignant / metabolism. Mixed Tumor, Malignant / pathology. Neoplasm Proteins / metabolism. Retrospective Studies

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  • (PMID = 20530158.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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43. Paal P, Falk M, Gruber E, Beikircher W, Ellerton J, Kainz H, Wenzel V, Brugger H: Effects of training time and feedback on ventilation skills in lay rescuers. Emerg Med J; 2010 Apr;27(4):313-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: At the assessment, tidal volume, minute volume, peak airway pressure, ventilation rate and stomach inflation rate were comparable between the 10 and 20 min groups.
  • After verbal feedback, at reassessment both groups increased tidal volume (assessment 0.75+/-0.24 vs reassessment 0.80+/-0.16 l/min; p=0.007), minute volume (9.1+/-3.0 vs 10.0+/-2.4 l/min; p=0.001), peak airway pressure (17.0+/-5.2 vs 18.3+/-3.4 cmH(2)O; p=0.003) and stomach inflation rate (67 vs 88%; p=0.02), while ventilation rate (12.3+/-2.1 vs 12.6+/-2.3 ventilations/min; p=NS) remained comparable.
  • Volunteers hyperventilated the manikin and produced excessive stomach inflation in this model.


44. Marciani L, Faulks R, Wickham MS, Bush D, Pick B, Wright J, Cox EF, Fillery-Travis A, Gowland PA, Spiller RC: Effect of intragastric acid stability of fat emulsions on gastric emptying, plasma lipid profile and postprandial satiety. Br J Nutr; 2009 Mar;101(6):919-28
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  • [Title] Effect of intragastric acid stability of fat emulsions on gastric emptying, plasma lipid profile and postprandial satiety.
  • The intragastric acid stability of emulsified fat may impact on gastric emptying, satiety and plasma lipid absorption.
  • The aim of the present study was to investigate whether, compared with an acid-unstable emulsion, an acid-stable fat emulsion would empty from the stomach more slowly, cause more rapid plasma lipid absorption and cause greater satiety.
  • Eleven healthy male volunteers received on two separate occasions 500 ml of 15 % (w/w) [13C]palmitate-enriched olive oil-in-water emulsion meals which were either stable or unstable in the acid gastric environment.
  • MRI was used to measure gastric emptying and the intragastric oil fraction of the meals.
  • The acid-unstable fat emulsion broke and rapidly layered in the stomach.
  • Gastric emptying of meal volume was slower for the acid-stable fat emulsion (P < 0.0001; two-way ANOVA).
  • The rate of energy delivery of fat from the stomach to the duodenum was not different up to t = 110 min.
  • This shows that it is possible to delay gastric emptying and increase satiety by stabilising the intragastric distribution of fat emulsions against the gastric acid environment.
  • [MeSH-major] Dietary Fats, Unsaturated / administration & dosage. Gastric Acid / metabolism. Gastrointestinal Contents. Lipids / blood. Satiation / physiology
  • [MeSH-minor] Adult. Analysis of Variance. Chylomicrons / metabolism. Echo-Planar Imaging. Emulsions. Gastric Emptying. Humans. Hydrogen-Ion Concentration. Male. Postprandial Period. Young Adult

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  • (PMID = 18680634.001).
  • [ISSN] 1475-2662
  • [Journal-full-title] The British journal of nutrition
  • [ISO-abbreviation] Br. J. Nutr.
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / / D14043
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chylomicrons; 0 / Dietary Fats, Unsaturated; 0 / Emulsions; 0 / Lipids
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45. Cassilly D, Kantor S, Knight LC, Maurer AH, Fisher RS, Semler J, Parkman HP: Gastric emptying of a non-digestible solid: assessment with simultaneous SmartPill pH and pressure capsule, antroduodenal manometry, gastric emptying scintigraphy. Neurogastroenterol Motil; 2008 Apr;20(4):311-9
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  • [Title] Gastric emptying of a non-digestible solid: assessment with simultaneous SmartPill pH and pressure capsule, antroduodenal manometry, gastric emptying scintigraphy.
  • Gastric emptying of digestible solids occurs after trituration of food particles.
  • The aim of this study was to determine if a non-digestible capsule given with a meal empties from the stomach with return of the fasting phase III MMC or during the fed pattern with the solid meal.
  • The SmartPill emptied from the stomach within 6 h in 14 of 15 subjects.
  • SmartPill gastric residence time (261 +/- 22 min) correlated strongly with time to the first phase III MMC (239 +/- 23 min; r = 0.813; P < 0.01) and correlated moderately with solid-phase gastric emptying (r = 0.606 with T-50% and r = 0.565 with T-90%).
  • In five subjects ingesting only water, SmartPill gastric residence time (92 +/- 44 min) correlated with the time to the first phase III MMC (87 +/- 30 min; r = 0.979; P < 0.01).
  • The non-digestible SmartPill given with a meal primarily empties from the stomach with the return of phase III MMCs occurring after emptying the solid-phase meal.
  • [MeSH-major] Digestion / physiology. Gastric Emptying / physiology

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  • (PMID = 18194154.001).
  • [ISSN] 1365-2982
  • [Journal-full-title] Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • [ISO-abbreviation] Neurogastroenterol. Motil.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK02921
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Capsules
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46. Afanas'eva AN, Evtushenko VA: [Endogenous intoxication in patients with stomach cancer observed immediately after surgery]. Klin Lab Diagn; 2005 Feb;(2):18-21
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  • [Title] [Endogenous intoxication in patients with stomach cancer observed immediately after surgery].
  • The purpose of the case study was to follow up the dynamics of the main El laboratory indices and to evaluate the correlation between them in patients with stomach cancer during the early postoperative period.
  • The study showed that, when patients with stomach cancer are admitted for surgical treatment, they have pronounced El, which intensifies even more postoperatively.
  • The full-fledged evaluation of the El nature must be used in choosing purposefully detoxication methods with the aim of promoting the quality of postoperative treatment of patients with stomach cancer.
  • [MeSH-major] Blood Proteins / analysis. Stomach Neoplasms / surgery. Toxemia / blood

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  • (PMID = 15804092.001).
  • [ISSN] 0869-2084
  • [Journal-full-title] Klinicheskaia laboratornaia diagnostika
  • [ISO-abbreviation] Klin. Lab. Diagn.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Blood Proteins
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47. Nagdeve NG, Sarin YK: Volvulus complicating dextrogastria in an infant. Indian Pediatr; 2007 Feb;44(2):142-4
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  • We report eventration of right hemi-diaphragm resulting in gastric volvulus of the right sided stomach in an infant.
  • The diagnosis of this rare association was made with contrast CT scan.
  • Patient was initially managed with reduction of stomach, plication of right hemi diaphragm, anterior gastropexy and Ladds procedure, but required re-laparotomy after two months for recurrent volvulus.
  • [MeSH-major] Diaphragmatic Eventration / complications. Stomach / abnormalities. Stomach Volvulus / complications

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  • (PMID = 17351308.001).
  • [ISSN] 0019-6061
  • [Journal-full-title] Indian pediatrics
  • [ISO-abbreviation] Indian Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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48. Gregersen LH, Friis S, Olsen JH: [Cancer in esophagus and cardia--incidence trends in Denmark]. Ugeskr Laeger; 2008 Apr 21;170(17):1460-4
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  • The study evaluates the incidence trends for esophagus- and stomach cancer in the period 1943-2003 with focus on changes since 1978.
  • The corresponding incidence rate for stomach cancer decreased over the entire study period from 21.9 per 100,000 in 1943-1947 to 9.7 per 100,000 in 1998-2003.
  • During the period 1978-2003 we observed a marked decrease in the incidence of adenocarcinoma in the distal stomach, whereas the incidence of adenocarcinoma in the cardia was constant in this period.
  • [MeSH-major] Adenocarcinoma / epidemiology. Carcinoma, Squamous Cell / epidemiology. Cardia. Esophageal Neoplasms / epidemiology. Stomach Neoplasms / epidemiology

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  • (PMID = 18462626.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Denmark
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49. Weiderpass E, Pukkala E: Time trends in socioeconomic differences in incidence rates of cancers of gastro-intestinal tract in Finland. BMC Gastroenterol; 2006;6:41
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  • RESULTS: There were 2.3 million individuals in the cohort under follow-up, with 1622 cases of cancer of the esophagus, 8069 stomach (non-cardia), 1116 cardia, 408 small intestine, 6361 colon, 5274 rectum, 1616 liver, 1756 gallbladder, and 5084 pancreas during 1971-1995.
  • Cancers of the esophagus, stomach, cardia, gallbladder and pancreas were most common among persons belonging to a low social class.
  • Incidence of stomach cancer decreased and incidence of colon cancer increased over time in both genders in all social classes, and the large differences between social classes remained unchanged over time.
  • [MeSH-major] Gastrointestinal Neoplasms / epidemiology. Social Class
  • [MeSH-minor] Aged. Cardia. Colonic Neoplasms / epidemiology. Esophageal Neoplasms / epidemiology. Finland / epidemiology. Gallbladder Neoplasms / epidemiology. Heart Neoplasms / epidemiology. Humans. Incidence. Intestinal Neoplasms / epidemiology. Liver Neoplasms / epidemiology. Middle Aged. Pancreatic Neoplasms / epidemiology. Rectal Neoplasms / epidemiology. Socioeconomic Factors

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  • (PMID = 17144908.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1769383
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50. Nadella SR, Bucking C, Grosell M, Wood CM: Gastrointestinal assimilation of Cu during digestion of a single meal in the freshwater rainbow trout (Oncorhynchus mykiss). Comp Biochem Physiol C Toxicol Pharmacol; 2006 Aug;143(4):394-401
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  • Cu concentrations in the supernatant (fluid phase) fell from about 0.06 micromol mL(-1) (63 microM) in the stomach at 2 h to about 0.003 micromol mL(-1) (3 microM) in the posterior intestine at 72 h.
  • Cu concentrations in the solid phase were 10 to 30-fold higher than in the fluid phase, and increased about 4-fold from the stomach at 2 h to the posterior intestine at 72 h.
  • The mid-intestine, and posterior intestine emerged as important sites of net Cu and water absorption and a potential role for the stomach in this process was also indicated.
  • [MeSH-minor] Animals. Gastrointestinal Contents / chemistry. Stomach / metabolism

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  • (PMID = 16765095.001).
  • [ISSN] 1532-0456
  • [Journal-full-title] Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
  • [ISO-abbreviation] Comp. Biochem. Physiol. C Toxicol. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 789U1901C5 / Copper
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51. Shi Y, Zhang LS, Zhao C, He CQ: [Comparison of therapeutic effects of acupuncture-cupping plus acupoint catgut embedding and electroacupuncture on simple obesity of stomach and intestine excess-heat type]. Zhongguo Zhen Jiu; 2006 Aug;26(8):547-50
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  • [Title] [Comparison of therapeutic effects of acupuncture-cupping plus acupoint catgut embedding and electroacupuncture on simple obesity of stomach and intestine excess-heat type].
  • OBJECTIVE: To search for a therapy of increasing clinical therapeutic effect on simple obesity with stomach and intestine excess-heat.
  • METHODS: Eighty-two cases of simple obesity with stomach and intestine excess-heat were randomly divided into group A (n=40) and group B (n=42).
  • CONCLUSION: Acupuncture, cupping plus acupoint catgut embedding therapy can increase therapeutic effect on simple obesity of stomach and intestine excess-heat type, and it is a better method for treatment of this disease.
  • [MeSH-minor] Acupuncture Therapy. Electroacupuncture. Hot Temperature. Humans. Intestines. Obesity / therapy. Stomach

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  • (PMID = 16941970.001).
  • [ISSN] 0255-2930
  • [Journal-full-title] Zhongguo zhen jiu = Chinese acupuncture & moxibustion
  • [ISO-abbreviation] Zhongguo Zhen Jiu
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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52. Hayashi K, Okayama Y, Ueno K, Miyabe K, Naitoh I, Hirai M, Kitajima Y, Ban T, Gotoh K, Yamada T, Sano H, Nakazawa T, Ohara H, Joh T, Itoh M: [Clinical evaluation of covered self-expandable metallic stent for unresectable malignant stomach pyloric region and duodenal obstruction]. Nihon Shokakibyo Gakkai Zasshi; 2006 Apr;103(4):405-14
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  • [Title] [Clinical evaluation of covered self-expandable metallic stent for unresectable malignant stomach pyloric region and duodenal obstruction].
  • We evaluated palliative treatment for unresectable malignant stomach pyloric region and the duodenal obstruction using covered self-expandable metallic stent (SEMS).
  • Fifty-seven patients (26 stomach pyloric stenosis, 31 duodenal stenosis) were underwent palliative treatment using covered SEMS.
  • The SEMS obstruction by tumor ingrowth or hyperplasia was not occurred, so SEMS was maintenance-free.
  • We concluded covered SEMS was useful palliative treatment because it prevented SEMS obstruction by tumor ingrowth or hyperplasia and it was maintenance-free.
  • [MeSH-major] Duodenal Obstruction / therapy. Pyloric Stenosis / therapy. Stents / standards. Stomach Neoplasms / complications
  • [MeSH-minor] Aged. Aged, 80 and over. Coated Materials, Biocompatible. Evaluation Studies as Topic. Female. Gallbladder Neoplasms / complications. Humans. Male. Middle Aged. Pancreatic Neoplasms / complications. Prosthesis Design

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  • (PMID = 16629459.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Coated Materials, Biocompatible
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53. Liao D, Zhao J, Gregersen H: Three-dimensional geometry analysis of the stomach in type II diabetic GK rats. Diabetes Res Clin Pract; 2006 Jan;71(1):1-13
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  • [Title] Three-dimensional geometry analysis of the stomach in type II diabetic GK rats.
  • AIMS/HYPOTHESIS: The stomach is affected in more than half of all diabetic patients.
  • The present study aims to investigate 3D geometry, 3D tension distribution and the elasticity in the stomach and its non-glandular and glandular regions in five non-diabetic and five Goto-Kakizaki (GK) rats (type 2 diabetic model).
  • Gastric compliance curves, the surface principal radii of curvature, the surface tension, and circumferential and longitudinal deformation-pressure curves were calculated based on 3D non-diabetic and the diabetic stomach models.
  • RESULTS: Diabetes lowered the gastric compliance in the non-glandular stomach and the whole stomach (P<0.02).
  • The radii of curvature and tension distribution were non-homogeneous in both the diabetic and the non-diabetic stomach due to the complex geometry.
  • CONCLUSIONS: The diabetic stomach exhibited lower material compliance not only in the proximal stomach but also in the entire stomach.
  • The biomechanical properties differed between regions and in different directions in both the non-diabetic and the diabetic stomach.
  • The changes due to diabetes may contribute to the delayed gastric emptying and the symptoms in diabetic patients.

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  • (PMID = 16054265.001).
  • [ISSN] 0168-8227
  • [Journal-full-title] Diabetes research and clinical practice
  • [ISO-abbreviation] Diabetes Res. Clin. Pract.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
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54. Ahmad Z, Memon A, Minhas K: Metachronous primary cancers of colon and stomach. J Coll Physicians Surg Pak; 2008 Feb;18(2):118-20
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  • [Title] Metachronous primary cancers of colon and stomach.
  • Synchronous or metachronous occurrence of esophageal, gastric and colonic cancers is a very rare occurrence, although there are several case reports in literature.
  • A case of a 41 years old man with metachronous cancers of colon and stomach is reported.
  • [MeSH-major] Colorectal Neoplasms / diagnosis. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adult. Humans. Male. Time

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  • (PMID = 18454902.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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55. Thomas T, Kaye PV, Ragunath K, Aithal G: Efficacy, safety, and predictive factors for a positive yield of EUS-guided Trucut biopsy: a large tertiary referral center experience. Am J Gastroenterol; 2009 Mar;104(3):584-91
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  • Site of lesion (pancreatic vs. extra-pancreatic, P<0.032), site of biopsy (stomach vs. duodenum vs. esophagus, P<0.001), and number of passes (< or =2 vs.>2, P<0.013) were predictors of a positive diagnostic yield in univariate analysis.
  • CONCLUSIONS: Diagnostic yield of EUS-TCB is higher when lesion is approached through the stomach and better when more than two passes were made.

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  • (PMID = 19262518.001).
  • [ISSN] 1572-0241
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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56. Ammori JB, Zhang WZ, Li JY, Chai BX, Mulholland MW: Effects of ghrelin on neuronal survival in cells derived from dorsal motor nucleus of the vagus. Surgery; 2008 Aug;144(2):159-67
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  • METHODS: DiI was injected into the stomach wall of rats to retrogradely label neurons of the dorsal motor nucleus of the vagus.
  • Exposure to interleukin (IL)-1 beta or tumor necrosis factor (TNF)-alpha increased apoptosis.
  • CONCLUSIONS: Neurons from the dorsal motor nucleus of the vagus that project to the stomach are reduced in number after induction of colitis in rats.

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  • (PMID = 18656621.001).
  • [ISSN] 1532-7361
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / DK043225-13S1; United States / NIDDK NIH HHS / DK / R01DK054032; United States / NIDDK NIH HHS / DK / R01 DK043225; United States / NCI NIH HHS / CA / T32CA009672; United States / NIDDK NIH HHS / DK / DK054032-09; United States / NIDDK NIH HHS / DK / R01 DK054032-09; United States / NIDDK NIH HHS / DK / R01 DK054032; United States / NIDDK NIH HHS / DK / R01 DK043225-13S1; United States / NCI NIH HHS / CA / T32 CA009672
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ghrelin; 0 / Receptors, Interleukin-1; 0 / Receptors, Interleukin-6; 0 / Tumor Necrosis Factor-alpha; 8T3HQG2ZC4 / Trinitrobenzenesulfonic Acid; XXE1CET956 / Indomethacin
  • [Other-IDs] NLM/ NIHMS63921; NLM/ PMC2547415
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57. Nakajima K, Inatsu S, Mizote T, Nagata Y, Aoyama K, Fukuda Y, Nagata K: Possible involvement of put A gene in Helicobacter pylori colonization in the stomach and motility. Biomed Res; 2008 Feb;29(1):9-18
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  • [Title] Possible involvement of put A gene in Helicobacter pylori colonization in the stomach and motility.
  • H. pylori is a gram-negative bacterium associated with gastric inflammation and peptic ulcer and considered a risk factor for gastric cancer in its natural habitat.
  • However, the energy metabolism of H. pylori in the stomach remains to be clarified. H. pylori shows rather high respiratory activity with L-proline and significantly large amounts of L-proline are present in the gastric juice from H. pylori infected patients.
  • We constructed a disrupted mutant of the put A gene, which encodes the proline utilization A (Put A) flavin-linked enzyme, in order to examine the role of put A in the gastric colonization of H. pylori.
  • DeltaputA had lost its ability to colonize the stomach of nude mice, an ability possessed by the wild-type.
  • These findings indicate that put A may play an important role in H. pylori colonization on the gastric mucus layer.
  • [MeSH-minor] Animals. Bacterial Physiological Phenomena. Biological Transport. Cells, Cultured. Chloramphenicol Resistance. Colony Count, Microbial. Female. Helicobacter Infections / enzymology. Heterotrophic Processes. Mice. Mice, Inbred BALB C. Mutagenesis, Insertional. Mutant Proteins. Proline / metabolism. Proline Oxidase / deficiency. Stomach / microbiology. Stomach / physiopathology. Transformation, Bacterial

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  • (PMID = 18344593.001).
  • [ISSN] 1880-313X
  • [Journal-full-title] Biomedical research (Tokyo, Japan)
  • [ISO-abbreviation] Biomed. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Membrane Proteins; 0 / Mutant Proteins; 0 / PutA protein, Bacteria; 9DLQ4CIU6V / Proline; EC 1.5.3.- / Proline Oxidase
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58. Jarikji ZH, Vanamala S, Beck CW, Wright CV, Leach SD, Horb ME: Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas. Dev Biol; 2007 Apr 15;304(2):786-99
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  • [Title] Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas.
  • Determining the functional attributes of pancreatic transcription factors is essential to understand how the pancreas is specified distinct from other endodermal organs, such as liver, stomach and duodenum, and to direct the differentiation of other cell types into pancreas.
  • Overexpression of the unmodified Ptf1a on the other hand has no effect in liver but is able to convert stomach and duodenum to pancreas.
  • Lastly, we demonstrate that, similar to mouse and zebrafish, Xenopus Ptf1a is essential for the initial specification of both endocrine and exocrine cells during normal pancreas development.

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  • (PMID = 17320068.001).
  • [ISSN] 0012-1606
  • [Journal-full-title] Developmental biology
  • [ISO-abbreviation] Dev. Biol.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK061215; United States / NIDDK NIH HHS / DK / R01 DK061215-05; United States / NIDDK NIH HHS / DK / DK-61215
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Herpes Simplex Virus Protein Vmw65; 0 / Recombinant Fusion Proteins; 0 / Transcription Factors; 0 / Xenopus Proteins; 0 / transcription factor PTF1
  • [Other-IDs] NLM/ NIHMS21756; NLM/ PMC4868342
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59. Icaza N MG, Núñez F ML, Torres A FJ, Díaz S NL, Várela G DE: [Geographical distribution of mortality caused by stomach, trachea, bronchi and lung malignant tumors in Chile]. Rev Med Chil; 2007 Nov;135(11):1397-405
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  • [Title] [Geographical distribution of mortality caused by stomach, trachea, bronchi and lung malignant tumors in Chile].
  • [Transliterated title] Distribución geográfica de mortalidad por tumores malignos de estómago, tráquea, bronquios y pulmón, Chile 1997-2004.
  • AIM: To describe the geographical distribution of stomach, trachea, bronchi and lung cancer mortality.
  • RESULTS: There is an excess mortality caused by stomach cancer in south central Chile, from Teno to Valdivia.
  • [MeSH-major] Neoplasms / mortality
  • [MeSH-minor] Adult. Aged. Bayes Theorem. Bronchial Neoplasms / mortality. Cause of Death. Chile / epidemiology. Female. Humans. Lung Neoplasms / mortality. Male. Middle Aged. Poisson Distribution. Stomach Neoplasms / mortality. Tracheal Neoplasms / mortality

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  • (PMID = 18259650.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Chile
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60. Al-Hendal A, Al-Sabbagh AJ, Al-Mishaan M, Abo Dief W: Upper gastrointestinal tract bleeding caused by a gastrointestinal stromal tumor of the stomach: a case report. Gulf J Oncolog; 2010 Jul;(8):44-7
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  • [Title] Upper gastrointestinal tract bleeding caused by a gastrointestinal stromal tumor of the stomach: a case report.
  • We report a case of upper gastrointestinal bleeding caused by a gastrointestinal stromal tumor in a 50-year old man.
  • Upper G.I endoscopy showed diffuse gastritis and an extrinsic compressing mass in the upper part of the stomach.
  • CT scan of the abdomen showed exophytic mass in the fundus of the stomach, with central necrosis.
  • [MeSH-major] Gastrointestinal Hemorrhage / etiology. Gastrointestinal Neoplasms / complications. Gastrointestinal Stromal Tumors / complications. Upper Gastrointestinal Tract / pathology

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  • (PMID = 20601339.001).
  • [ISSN] 2078-2101
  • [Journal-full-title] The Gulf journal of oncology
  • [ISO-abbreviation] Gulf J Oncolog
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Kuwait
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61. Hayakawa T, Kuwahara S, Maeda S, Tanaka K, Seki M: Distribution of vagal CGRP-immunoreactive fibers in the lower esophagus and the cardia of the stomach of the rat. J Chem Neuroanat; 2009 Oct;38(2):124-9
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  • [Title] Distribution of vagal CGRP-immunoreactive fibers in the lower esophagus and the cardia of the stomach of the rat.
  • We have examined whether the smooth muscle fibers in the lower esophagus and the cardia of the stomach of the rat are innervated by calcitonin gene-related peptide-immunoreactive (CGRP-ir) fibers coming from the nucleus ambiguus.
  • [MeSH-major] Axons / metabolism. Calcitonin Gene-Related Peptide / metabolism. Esophagus / innervation. Muscle, Smooth / innervation. Stomach / innervation. Vagus Nerve / metabolism

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  • (PMID = 19691152.001).
  • [ISSN] 1873-6300
  • [Journal-full-title] Journal of chemical neuroanatomy
  • [ISO-abbreviation] J. Chem. Neuroanat.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / 2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt; 0 / Fluorescent Dyes; 0 / Stilbamidines; 83652-28-2 / Calcitonin Gene-Related Peptide
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62. Berger-Achituv S, Zissin R, Shenkman Z, Gutermacher M, Erez I: Gastric emptying time of oral contrast material in children and adolescents undergoing abdominal computed tomography. J Pediatr Gastroenterol Nutr; 2010 Jul;51(1):31-4
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  • [Title] Gastric emptying time of oral contrast material in children and adolescents undergoing abdominal computed tomography.
  • OBJECTIVES: : Considering the hazards of pulmonary aspiration of oral contrast material (OCM) during general anesthesia, we investigated the gastric emptying time (GET) of OCM in children and adolescents undergoing abdominal computed tomography (CT).
  • To estimate the GET of OCM, CT images were reviewed to examine whether the stomach was empty or full of OCM at the time of imaging.
  • RESULTS: : The Kaplan-Meier curve showed that 75% of the patients had OCM in the stomach 48 +/- 5.2 minutes after its completion, 50% after 74 +/- 7.9 minutes, and 25% after 135 +/- 32.5 minutes; 1 patient still had OCM after 162 minutes.
  • Except for the length of time taken to drink the contrast material (< or =90 minutes was associated with slower empting of the stomach; log rank, P = 0.03), GET of OCM was not correlated with sex (P = 0.16), age (P = 0.15), weight (P = 0.13), or type of diagnosis (P = 0.41).
  • [MeSH-major] Contrast Media / pharmacokinetics. Gastric Emptying. Radiography, Abdominal. Respiratory Aspiration / prevention & control. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adolescent. Anesthesia, General. Appendicitis / radiography. Child. Child, Preschool. Female. Humans. Ileus / radiography. Iothalamic Acid / administration & dosage. Iothalamic Acid / analogs & derivatives. Kaplan-Meier Estimate. Male. Stomach / radiography. Time Factors. Wounds and Injuries / radiography

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  • (PMID = 20410846.001).
  • [ISSN] 1536-4801
  • [Journal-full-title] Journal of pediatric gastroenterology and nutrition
  • [ISO-abbreviation] J. Pediatr. Gastroenterol. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 16CHD79MIX / Iothalamic Acid; 967RDI7Z6K / ioxitalamic acid
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63. Lin ML, Wirth A, Chao M, Milner AD, DiIulio J, MacManus M, Seymour JF: Radiotherapy for low-grade gastric marginal zone lymphoma: a retrospective study. Intern Med J; 2007 Mar;37(3):172-80
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  • [Title] Radiotherapy for low-grade gastric marginal zone lymphoma: a retrospective study.
  • BACKGROUND: We evaluated the efficacy and toxicity of radiotherapy (RT) in patients with low-grade gastric marginal zone lymphoma.
  • METHODS: A retrospective review of consecutive cases of gastric marginal zone lymphoma treated by radical RT at the Peter MacCallum Cancer Centre and Radiation Oncology Victoria between January 1980 and September 2003 was carried out.
  • The radiation fields included the stomach plus perigastric and coeliac nodes in 15 patients (83%), stomach plus spleen in 2 patients (11%) and stomach plus para-aortic nodes in 1 patient (6%).
  • CONCLUSION: Radiotherapy is an effective, well-tolerated treatment for patients with low-grade gastric marginal zone lymphoma, including those who have had prior therapy.
  • [MeSH-major] Lymphoma, Non-Hodgkin / radiotherapy. Stomach Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Agents / therapeutic use. Biopsy. Disease Progression. Dose-Response Relationship, Radiation. Female. Helicobacter Infections / drug therapy. Humans. Male. Medical Records. Middle Aged. Neoplasm Staging. Retreatment. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17316336.001).
  • [ISSN] 1445-5994
  • [Journal-full-title] Internal medicine journal
  • [ISO-abbreviation] Intern Med J
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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64. Nikfarjam M, McGee MF, Trunzo JA, Onders RP, Pearl JP, Poulose BK, Chak A, Ponsky JL, Marks JM: Transgastric natural-orifice transluminal endoscopic surgery peritoneoscopy in humans: a pilot study in efficacy and gastrotomy site selection by using a hybrid technique. Gastrointest Endosc; 2010 Aug;72(2):279-83
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  • OBJECTIVE: To characterize the efficacy of various anterior gastric access locations for diagnostic transgastric NOTES peritoneoscopy in humans.
  • PATIENTS: Patients undergoing planned laparoscopic gastrectomy or gastrotomy involving the anterior aspect of the stomach were eligible.
  • INTERVENTIONS: An anterior gastric site for NOTES gastrotomy was chosen and transgastric NOTES access was independently established after laparoscopic abdominal exploration.
  • CONCLUSION: NOTES peritoneoscopy with a gastrotomy on the anterior stomach permits adequate visualization of organs in the right upper and both lower quadrants.
  • Visualization of the left upper quadrant and spleen is, however, limited unless access is gained on the greater curvature of the stomach.
  • [MeSH-major] Endoscopy, Gastrointestinal / methods. Gastrectomy / methods. Gastrostomy. Laparoscopy / methods. Stomach Neoplasms / surgery

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  • [Copyright] Copyright 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20541750.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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65. Tomita H, Yamada Y, Oyama T, Hata K, Hirose Y, Hara A, Kunisada T, Sugiyama Y, Adachi Y, Linhart H, Mori H: Development of gastric tumors in Apc(Min/+) mice by the activation of the beta-catenin/Tcf signaling pathway. Cancer Res; 2007 May 1;67(9):4079-87
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  • [Title] Development of gastric tumors in Apc(Min/+) mice by the activation of the beta-catenin/Tcf signaling pathway.
  • Although several lines of evidence suggest the involvement of the Wnt pathway in the development of gastric cancers, the functional significance of the pathway in gastric carcinogenesis is still poorly defined.
  • To examine the role of the Apc/beta-catenin signaling pathway in the development of gastric cancers, we investigated the gastric mucosa of the Apc(Min/+) mouse, which is a murine model for familial adenomatous polyposis, carrying a germ-line mutation at codon 850 of Apc.
  • We found that aged Apc(Min/+) mice spontaneously develop multiple tumors in the stomach, which are accompanied by loss of heterozygosity of Apc.
  • Such tumors consisted of adenomatous glands with strong nuclear accumulation of beta-catenin.
  • Even a single adenomatous gland already showed nuclear accumulation of beta-catenin, suggesting that Apc/beta-catenin pathway is an initiating event in gastric tumorigenesis in Apc(Min/+) mice.
  • Furthermore, beta-catenin/Tcf reporter transgenic mice with Apc(Min) allele showed higher levels of the transcriptional activity of beta-catenin/Tcf in the gastric tumors.
  • We also treated Apc(Min/+) and wild-type mice with N-methyl-N-nitrosourea (MNU), an alkylating agent that induces adenomas and adenocarcinomas in the stomach.
  • Consequently, MNU-treated Apc(Min/+) mice significantly enhanced the tumor development in comparison with Apc(Min/+) mice or MNU-treated wild-type mice.
  • Several gastric tumors in MNU-treated Apc(Min/+) mice showed invasion into the submucosal layer.
  • These results indicate that the Apc/beta-catenin pathway may play an important role in at least subset of gastric carcinomas.
  • In addition, Apc(Min/+) mice combined with MNU could be a useful short-term model to investigate multistage carcinogenesis in the stomach.
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma / metabolism. Stomach Neoplasms / genetics. Stomach Neoplasms / metabolism. T Cell Transcription Factor 1 / metabolism. beta Catenin / metabolism
  • [MeSH-minor] Animals. Cell Nucleus / metabolism. Female. Gene Expression. Genes, APC. Loss of Heterozygosity. Male. Mice. Mice, Inbred C57BL. Mice, Transgenic. Neoplasm Invasiveness. Signal Transduction. Transcription, Genetic


66. Onyesom I, Okoh PN: Quantitative analysis of nitrate and nitrite contents in vegetables commonly consumed in Delta State, Nigeria. Br J Nutr; 2006 Nov;96(5):902-5
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  • Thiocyanate, which is secreted into the stomach contents of animals, has been demonstrated to catalyse the formation of nitrosamines (potent carcinogens) in the stomach from secondary amines and nitrite.
  • We conclude that frequent consumption of such vegetables whose nitrate and nitrite contents are high by cassava-eating individuals might put them at risk of developing stomach cancer and other possible results of nitrate and/or nitrite toxicity.

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  • (PMID = 17092380.001).
  • [ISSN] 0007-1145
  • [Journal-full-title] The British journal of nutrition
  • [ISO-abbreviation] Br. J. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Nitrates; 0 / Nitrites; 0 / Soil
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67. Mulè F, Zizzo MG, Amato A, Feo S, Serio R: Evidence for a role of inducible nitric oxide synthase in gastric relaxation of mdx mice. Neurogastroenterol Motil; 2006 Jun;18(6):446-54
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  • [Title] Evidence for a role of inducible nitric oxide synthase in gastric relaxation of mdx mice.
  • Alterations of gastric mechanical activity have been reported in mdx mouse, animal model for Duchenne muscular dystrophy.
  • This study examined if alterations in the vasoactive intestinal polypeptide (VIP) system are present in mdx stomach.
  • Gastric mechanical activity was recorded in vitro as changes of endoluminal pressure and neurally or pharmacologically evoked relaxations were analysed in mdxvs normal stomach.
  • Relaxations to sodium nitroprusside in mdx stomach showed no difference in comparison with normal preparations.
  • In normal stomach, VIP produced relaxation, which was reduced by VIP6-28, antagonist of VIP receptors, but was not modified by Nomega-nitro-L-arginine methyl ester (L-NAME), 1-H-oxodiazol-[1,2,4]-[4,3-a]quinoxaline-1-one (ODQ) or by N-(3-(aminomethyl)-benzyl)acetamidine (1400W) and aminoguanidine, inhibitors of iNOS.
  • In contrast, in mdx stomach VIP responses were antagonized not only by VIP6-28, but also by L-NAME, ODQ, 1400W or aminoguanidine.
  • In normal stomach, the slow relaxation evoked by stimulation at high frequency was reduced by VIP6-28, but it was unaffected by 1400W or aminoguanidine.
  • In mdx stomach, it was reduced by VIP6-28 or 1400W, which did not show additive effects. iNOS mRNA was expressed only in mdx stomach.
  • The results suggest that in mdx gastric preparations, iNOS is functionally expressed, being involved in the slow relaxation induced by VIP.
  • [MeSH-major] Muscle Relaxation / physiology. Nitric Oxide Synthase Type II / metabolism. Stomach / physiology. Vasoactive Intestinal Peptide / metabolism

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  • (PMID = 16700724.001).
  • [ISSN] 1350-1925
  • [Journal-full-title] Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • [ISO-abbreviation] Neurogastroenterol. Motil.
  • [Language] eng
  • [Grant] Italy / Telethon / / GGP030250
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one; 0 / Enzyme Inhibitors; 0 / Imines; 0 / N-((3-(aminomethyl)phenyl)methyl)ethanimidamide; 0 / Oxadiazoles; 0 / Quinoxalines; 0 / RNA, Messenger; 0 / Receptors, Vasoactive Intestinal Peptide; 37221-79-7 / Vasoactive Intestinal Peptide; EC 1.14.13.39 / Nitric Oxide Synthase Type II; V55S2QJN2X / NG-Nitroarginine Methyl Ester
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68. Rygl M, Snajdauf J, Lisý J, Vyhnánek M, Pachmanová D, Pýcha K: [Surgical complications following oesophageal replacement by stomach in childhood]. Rozhl Chir; 2006 Oct;85(10):489-93
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  • [Title] [Surgical complications following oesophageal replacement by stomach in childhood].
  • AIM: Assessment of surgical complications and options for their therapy following replacement of oesophagus by stomach.
  • METHODOLOGY AND MATERIAL: A retrospective study of clinical and pathological data collected from 25 children, who underwent replacement procedures of their oesophagus by stomach during the 1992-2005 period.
  • CONCLUSIONS: Transposition of the stomach is a suitable method of choice for oesophageal replacement in childhood, providing good quality of life for majority of patients.
  • Early and late surgical complications correspond with a degree of seriousness of the disorder and require treatment and long term follow up to be conducted in a specialized clinic.
  • [MeSH-major] Esophageal Atresia / surgery. Esophageal Stenosis / surgery. Esophagoplasty / adverse effects. Stomach / transplantation

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  • (PMID = 17233173.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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69. Gardikis S, Danielides V, Tsalkidis A, Vaos G, Chatzimicael A, Simopoulos C: Unusual retrograde movement of a safety-pin ingested by an infant. Acta Paediatr; 2005 May;94(5):629-31
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  • Here we present the first reported case of an ingested open safety-pin in a 7-mo-old boy that migrated from the stomach to the oesophagus.
  • CONCLUSION: This rare complication is probably due to a gastro-oesophageal reflux effect, and for this reason we propose that all infants with safety-pins and other sharp objects in the stomach should be positioned in a semi-upright position.

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  • (PMID = 16188755.001).
  • [ISSN] 0803-5253
  • [Journal-full-title] Acta paediatrica (Oslo, Norway : 1992)
  • [ISO-abbreviation] Acta Paediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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70. Scatizzi M, Calistri M, Feroci F, Girardi LR, Moraldi L, Rubio CA, Moretti R, Nesi G: Gastric duplication cyst in an adult: case report. In Vivo; 2005 Nov-Dec;19(6):975-8
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  • [Title] Gastric duplication cyst in an adult: case report.
  • Duplication cysts of the stomach are uncommon findings in adult patients and diagnosis is often overlooked.
  • We report a case of a non-communicating cyst of the stomach in a 67-year-old man.
  • [MeSH-major] Cysts / congenital. Cysts / pathology. Cysts / surgery. Stomach / abnormalities. Stomach Diseases / congenital. Stomach Diseases / surgery
  • [MeSH-minor] Adrenal Cortex Neoplasms / diagnosis. Adrenocortical Adenoma / diagnosis. Aged. Contrast Media / administration & dosage. Diagnosis, Differential. Follow-Up Studies. Gastrointestinal Stromal Tumors / diagnosis. Gastroscopy. Humans. Male. Stomach Neoplasms / diagnosis. Time Factors. Tomography, X-Ray Computed. Treatment Outcome. X-Rays

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  • (PMID = 16277009.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Contrast Media
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71. Kubota E, Kataoka H, Hayashi K, Kamiya T, Sasaki M, Ogasawara N, Yamada T, Wada T, Mori Y, Mizoshita T, Shimura T, Mizushima T, Okamoto Y, Ohara H, Joh T: Advanced stomach and pancreas cancer successfully treated with combination chemotherapy with S-1/paclitaxel/lentinan. Hepatogastroenterology; 2009 Jan-Feb;56(89):106-10
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  • [Title] Advanced stomach and pancreas cancer successfully treated with combination chemotherapy with S-1/paclitaxel/lentinan.
  • We report a case of stomach and pancreas cancers that showed marked responses to combination chemotherapy consisting of S-1, paclitaxel (PTX), and lentinan (LNT).
  • A 67-year-old Japanese man was referred to our hospital in July 2005, diagnosed with advanced gastric cancer.
  • Subsequent examination revealed the existence of cancers in the stomach and pancreas, with lymph nodes and peritoneal metastasis and ascites.
  • After completion of 4 courses, the patient achieved partial response (PR), with complete disappearance of the primary gastric tumor and ascites.
  • Combination chemotherapy with S-1/PTX/LNT can be an effective treatment for unresectable advanced gastric carcinoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Pancreatic Neoplasms / drug therapy. Stomach Neoplasms / drug therapy
  • [MeSH-minor] Aged. Humans. Lymphatic Metastasis. Male. Paclitaxel / administration & dosage. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / radiography. Peritoneal Neoplasms / secondary. Tomography, X-Ray Computed

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  • (PMID = 19453038.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] P88XT4IS4D / Paclitaxel
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72. Baré M, Cabrol J, Real J, Navarro G, Campo R, Pericay C, Sarría A: In-hospital mortality after stomach cancer surgery in Spain and relationship with hospital volume of interventions. BMC Public Health; 2009;9:312
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  • [Title] In-hospital mortality after stomach cancer surgery in Spain and relationship with hospital volume of interventions.
  • BACKGROUND: There is no consensus about the possible relation between in-hospital mortality in surgery for gastric cancer and the hospital annual volume of interventions.
  • The objectives were to identify factors associated to greater in-hospital mortality for surgery in gastric cancer and to analyze the possible independent relation between hospital annual volume and in-hospital mortality.
  • METHODS: We performed a retrospective cohort study of all patients discharged after surgery for stomach cancer during 2001-2002 in four regions of Spain using the Minimum Basic Data Set for Hospital Discharges.
  • [MeSH-major] Hospital Mortality. Stomach Neoplasms / mortality

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  • (PMID = 19709446.001).
  • [ISSN] 1471-2458
  • [Journal-full-title] BMC public health
  • [ISO-abbreviation] BMC Public Health
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2749825
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73. Lang R, Bardelmeier I, Weiss C, Rubach M, Somoza V, Hofmann T: Quantitation of (beta)N-Alkanoyl-5-hydroxytryptamides in coffee by means of LC-MS/MS-SIDA and assessment of their gastric acid secretion potential using the HGT-1 cell assay. J Agric Food Chem; 2010 Feb 10;58(3):1593-602
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  • [Title] Quantitation of (beta)N-Alkanoyl-5-hydroxytryptamides in coffee by means of LC-MS/MS-SIDA and assessment of their gastric acid secretion potential using the HGT-1 cell assay.
  • To estimate the potential contribution of the C5HTs to the phenomenon of stomach irritation after ingestion of coffee brew, in vitro cell studies were performed with pure individual 5-hydroxytryptamides and a mixture of the predominating derivatives in ratios matching those found in coffee.
  • All substances tested induced a decrease in the intracellular proton index (IPX) coined as an indicator of stomach acid secretion.
  • In conclusion, not the grade of saturation seems to determine the C5HT's mode of action in driving the stomach acid secretion, rather than the fatty acid chain length.
  • [MeSH-major] Chromatography, Liquid / methods. Coffee / chemistry. Gastric Acid / secretion. Gastric Mucosa / secretion. Tandem Mass Spectrometry / methods. Tryptamines / chemistry

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  • (PMID = 20030342.001).
  • [ISSN] 1520-5118
  • [Journal-full-title] Journal of agricultural and food chemistry
  • [ISO-abbreviation] J. Agric. Food Chem.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coffee; 0 / Tryptamines
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74. Dong GH, Wang GQ, Gong LP, Wang JF, Mo XL, Liu HG, Dong LN, Zhou YQ, Zhang XM, Feng ZB, Gao ZF, Ye HT: [A clinical study of chromosome translocations in extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue in Chinese patients]. Zhonghua Nei Ke Za Zhi; 2009 Mar;48(3):181-5
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  • q21) API2-MALT1 was found with the highest frequency in MALT lymphoma from lungs (47%, 8/17) and small intestine (29%, 4/14), followed by salivary gland (17%, 1/6), stomach (14%, 12/84) and ocular adnexae (6%, 4/68). t (1;. 14) (p22;.
  • q32) was only detected in lungs (12%, 2/17) and stomach (1%, 1/84). t (14;. 18) (q32;.
  • BCL6 gene involved translocation was detected in salivary gland (17%, 1/6) and stomach (4%, 3/84).

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  • (PMID = 19576081.001).
  • [ISSN] 0578-1426
  • [Journal-full-title] Zhonghua nei ke za zhi
  • [ISO-abbreviation] Zhonghua Nei Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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75. Zhang W, Lei Z, Su J, Chen S: Expression of ghrelin in the porcine hypothalamo-pituitary-ovary axis during the estrous cycle. Anim Reprod Sci; 2008 Dec;109(1-4):356-67
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  • Ghrelin, a 28-amino acid acylated peptide produced mainly by the stomach, has various functions.
  • This study was to investigate the expression of ghrelin in the cyclic porcine hypothalamo-pituitary-ovary axis and stomach by semiquantitative RT-PCR and immunohistochemical method.
  • In the stomach, the expression of ghrelin mRNA had the same tendency as that of the porcine ovary.
  • In gastric mucosa, ghrelin immunoreactive cells were detected in the estrus, diestrus1 and diestrus2, but few ghrelin positive cells were seen in the proestrus.

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  • (PMID = 18295988.001).
  • [ISSN] 1873-2232
  • [Journal-full-title] Animal reproduction science
  • [ISO-abbreviation] Anim. Reprod. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Ghrelin; 0 / RNA, Messenger; 63231-63-0 / RNA
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76. Drevon-Gaillot E, Perron-Lepage MF, Clément C, Burnett R: A review of background findings in cynomolgus monkeys (Macaca fascicularis) from three different geographical origins. Exp Toxicol Pathol; 2006 Nov;58(2-3):77-88
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  • Samples of stomach, colon, kidney, heart, liver, spleen and lung were examined microscopically and graded to characterize the degree of lymphoplasmacytic cell infiltration.
  • Generally, only the antral mucosa of the stomach was infiltrated in cynomolgus monkeys from The Philippines, whereas both the fundic and antral regions were infiltrated in those from Vietnam.
  • Spiral-shaped bacteria were observed in the stomach of monkeys from all three sources, but their presence did not correlate with the severity of the gastric infiltrate.

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  • (PMID = 16984807.001).
  • [ISSN] 0940-2993
  • [Journal-full-title] Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie
  • [ISO-abbreviation] Exp. Toxicol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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77. Satyanarayana MN: Capsaicin and gastric ulcers. Crit Rev Food Sci Nutr; 2006;46(4):275-328
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  • [Title] Capsaicin and gastric ulcers.
  • In recent years, infection of the stomach with the organism Helicobacter Pylori has been found to be the main cause of gastric ulcers, one of the common ailments afflicting humans.
  • Excessive acid secretion in the stomach, reduction in gastric mucosal blood flow, constant intake of non-steroid anti-inflammatory drugs (NSAIDS), ethanol, smoking, stress etc. are also considered responsible for ulcer formation.
  • The prevalent notion among sections of population in this country and perhaps in others is that "red pepper" popularly known as "Chilli," a common spice consumed in excessive amounts leads to "gastric ulcers" in view of its irritant and likely acid secreting nature.
  • Capsaicin does not stimulate but inhibits acid secretion, stimulates alkali, mucus secretions and particularly gastric mucosal blood flow which help in prevention and healing of ulcers.
  • Capsaicin acts by stimulating afferent neurons in the stomach and signals for protection against injury causing agents.
  • Epidemiologic surveys in Singapore have shown that gastric ulcers are three times more common in the "Chinese" than among Malaysians and Indians who are in the habit of consuming more chillis.
  • [MeSH-major] Capsaicin. Gastric Acid / secretion. Gastric Mucosa / drug effects. Stomach Ulcer / prevention & control

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  • (PMID = 16621751.001).
  • [ISSN] 1040-8398
  • [Journal-full-title] Critical reviews in food science and nutrition
  • [ISO-abbreviation] Crit Rev Food Sci Nutr
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] S07O44R1ZM / Capsaicin
  • [Number-of-references] 447
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78. Hamoui N, Crookes PF, Kaufman HS: Percutaneous gastric drainage as a treatment for small bowel obstruction after gastric bypass. Obes Surg; 2007 Oct;17(10):1411-2
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  • [Title] Percutaneous gastric drainage as a treatment for small bowel obstruction after gastric bypass.
  • The authors report the case of a patient who developed small bowel obstruction after laparoscopic gastric bypass.
  • Imaging revealed an obstruction at the enteroenterostomy resulting in dilation of the bypassed stomach and proximal small bowel.
  • The bypassed stomach was percutaneously drained using CT guidance, leading to resolution of the small bowel obstruction.
  • Biliopancreatic limb obstructions can be successfully treated non-operatively after gastric bypass.
  • [MeSH-major] Drainage / methods. Gastric Bypass / adverse effects. Intestinal Obstruction / surgery
  • [MeSH-minor] Dilatation, Pathologic. Female. Humans. Middle Aged. Stomach / diagnostic imaging. Stomach / pathology. Surgery, Computer-Assisted. Tomography, X-Ray Computed

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  • (PMID = 18098404.001).
  • [ISSN] 0960-8923
  • [Journal-full-title] Obesity surgery
  • [ISO-abbreviation] Obes Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Wang Y, Liu J: Combination of bypassing stomach and vagus dissection in high-fat diet-induced obese rats-a long-term investigation. Obes Surg; 2010 Mar;20(3):375-9
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  • [Title] Combination of bypassing stomach and vagus dissection in high-fat diet-induced obese rats-a long-term investigation.
  • BACKGROUND: Gastric bypass is the most popular technique in obesity therapy.
  • Rats in the gastric bypass group (GB1 and GB2) and the bypass with vagus dissection group (VD1 and VD2) received surgery.
  • [MeSH-major] Gastric Bypass. Hypothalamus / metabolism. Obesity, Morbid / metabolism. Obesity, Morbid / surgery. Vagus Nerve / surgery. Weight Gain

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  • (PMID = 19472021.001).
  • [ISSN] 1708-0428
  • [Journal-full-title] Obesity surgery
  • [ISO-abbreviation] Obes Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dietary Fats; 0 / Ghrelin; 0 / Leptin
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80. Tan XH, Zhao M, Pan KF, Dong Y, Dong B, Feng GJ, Jia G, Lu YY: Frequent mutation related with overexpression of DNA polymerase beta in primary tumors and precancerous lesions of human stomach. Cancer Lett; 2005 Mar 18;220(1):101-14
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  • [Title] Frequent mutation related with overexpression of DNA polymerase beta in primary tumors and precancerous lesions of human stomach.
  • To explore whether DNA polymerase beta (pol beta) contributes to the malignant transformation of gastric mucosa, we examined pol beta in gastric tumor cell lines, primary tumors and precancerous lesions.
  • Point mutations of pol beta were detected in 6 of 13 cell lines and 23 of 104 tissues including 35.0% (14/40) of gastric cancer (GC), 30.0% (3/10) of dysplasia (Dys), 28.6% (4/14) of intestinal metaplasia (IM) and 10.5% (2/19) of chronic atrophic gastritis (CAG), respectively.
  • The level of pol beta expression in tumors was higher than that of their matched normal tissues and gradual changes from GC, Dys, CAG to IM.
  • These results indicate that the mutation and overexpression of pol beta may influence the progression during gastric carcinogenesis.
  • [MeSH-major] DNA Polymerase beta / genetics. Mutation. Precancerous Conditions / genetics. Stomach Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Alternative Splicing. Base Sequence. Female. Humans. Male. Middle Aged. RNA, Messenger / metabolism. Tumor Cells, Cultured

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  • (PMID = 15737693.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / RNA, Messenger; EC 2.7.7.- / DNA Polymerase beta
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81. Kalnina Z, Silina K, Bruvere R, Gabruseva N, Stengrevics A, Barnikol-Watanabe S, Leja M, Line A: Molecular characterisation and expression analysis of SEREX-defined antigen NUCB2 in gastric epithelium, gastritis and gastric cancer. Eur J Histochem; 2009 Jan-Mar;53(1):7-18
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  • [Title] Molecular characterisation and expression analysis of SEREX-defined antigen NUCB2 in gastric epithelium, gastritis and gastric cancer.
  • In our previous study we identified NUCB2 as a potential tumour antigen eliciting autoantibody responses in 5.4% of gastric cancer patients but not in the healthy individuals.The current study aimed to elucidate the molecular mechanism underlying NUCB2 immunogenicity and to gain an insight into the physiological functions of NUCB2 in the stomach. mRNA expression analysis demonstrated that NUCB2 is ubiquitously expressed in normal tissues, including lymphoid tissues, and downregulated in gastric tumours when compared with the adjacent relatively normal stomach tissues.The search for molecular alterations resulted in the identification of novel mRNA variants transcribed from an alternative promoter and expressed predominantly in gastric cancers.
  • Western blot analysis demonstrated that the protein levels correspond to mRNA levels and revealed that NUCB2 is phosphorylated in gastric mucosa.
  • Furthermore, a 55 kDa isoform,generated presumably by yet an unidentified post-translational modification was detected in gastric tumours and AGS gastric cancer cells but was absent in the relatively normal gastric mucosa and thereby might have served as a trigger for the immune response against NUCB2.
  • Staining of stomach tissue microarray with anti-NUCB2 antibody revealed that it is expressed in the secretory granules of chief cells and in the cytoplasm of parietal cells in the functioning gastric glands which are lost in atrophic glands and tumour cells.
  • Hence we propose that NUCB2 may be implicated in gastric secretion by establishing an agonist-releasable Ca2+ store in ER or Golgi apparatus, signalling via heterotrimeric Galpha proteins and/or mediating the exocytosis of the secretory granules.
  • [MeSH-major] Calcium-Binding Proteins / metabolism. DNA-Binding Proteins / metabolism. Gastric Mucosa / metabolism. Gastritis / metabolism. Stomach Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Autoantibodies / analysis. Down-Regulation. Female. Humans. Male. Middle Aged. Nerve Tissue Proteins. Parietal Cells, Gastric / immunology. Protein Processing, Post-Translational. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 19351608.001).
  • [ISSN] 1121-760X
  • [Journal-full-title] European journal of histochemistry : EJH
  • [ISO-abbreviation] Eur J Histochem
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Calcium-Binding Proteins; 0 / DNA-Binding Proteins; 0 / Nerve Tissue Proteins; 0 / nucleobindin
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82. Kerger BD, Butler WJ, Paustenbach DJ, Zhang J, Li S: Cancer mortality in chinese populations surrounding an alloy plant with chromium smelting operations. J Toxicol Environ Health A; 2009;72(5):329-44
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  • The average lung-, stomach-, and all-cancer mortality rates for the three agricultural villages without Cr(VI) in groundwater were not statistically different from those of the five agricultural villages with Cr(VI) in groundwater.
  • Further, the industrial town in which the Cr(VI) source was located had different demographics and a different pattern of stomach and lung cancers compared to the adjacent agricultural villages, regardless of Cr(VI) groundwater exposure.
  • The overall findings in the studied population do not indicate a dose-response relationship or a coherent pattern of association of lung-, stomach-, or all-cancer mortality with exposure to Cr(VI)-contaminated groundwater.
  • [MeSH-major] Alloys. Chromium. Metallurgy. Neoplasms / mortality

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  • (PMID = 19184749.001).
  • [ISSN] 1528-7394
  • [Journal-full-title] Journal of toxicology and environmental health. Part A
  • [ISO-abbreviation] J. Toxicol. Environ. Health Part A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Alloys; 0 / Water Pollutants, Chemical; 0R0008Q3JB / Chromium; 18540-29-9 / chromium hexavalent ion
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83. Leser TD, Knarreborg A, Worm J: Germination and outgrowth of Bacillus subtilis and Bacillus licheniformis spores in the gastrointestinal tract of pigs. J Appl Microbiol; 2008 Apr;104(4):1025-33
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  • The lowest number of spores was found in the stomach, increasing in the small intestine to approx.
  • Spores accounted for 72% of the total counts after 4-6 h in the stomach and proximal part of the small intestine.
  • After 24 h, spores constituted only 12% of the total counts in the stomach, caecum, and mid-colon.
  • [MeSH-minor] Administration, Oral. Animals. Bacillus subtilis / growth & development. Bacillus subtilis / physiology. Bacillus subtilis / ultrastructure. Feces / microbiology. Flow Cytometry. Intestine, Small / microbiology. Microscopy, Phase-Contrast. Spores, Bacterial. Stomach / microbiology. Swine

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  • (PMID = 18005348.001).
  • [ISSN] 1365-2672
  • [Journal-full-title] Journal of applied microbiology
  • [ISO-abbreviation] J. Appl. Microbiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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84. Boyle P, Ferlay J: Cancer incidence and mortality in Europe, 2004. Ann Oncol; 2005 Mar;16(3):481-8
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  • Lung cancer was also the most common cause of cancer death (341,800 deaths), followed by colorectal (203,700), stomach (137,900) and breast (129,900).
  • To make great progress quickly against cancer in Europe, the need is evident to make a concerted attack on the big killers: lung, colorectal, breast and stomach cancer.
  • Stomach cancer rates are falling everywhere in Europe and public health measures are available to reduce the incidence and mortality of lung cancer, colorectal cancer and breast cancer.

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  • (PMID = 15718248.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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85. Kong F, Singh RP: Disintegration of solid foods in human stomach. J Food Sci; 2008 Jun;73(5):R67-80
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  • [Title] Disintegration of solid foods in human stomach.
  • Knowledge of the disintegration of solid foods in human stomach is essential to assess the bioavailability of nutrients in the gastrointestinal (GI) tract.
  • A comprehensive review of food gastric digestion, focusing on disintegration of solid foods, is presented.
  • Stomach physiology is briefly introduced, including composition and rheological properties of gastric contents, stomach wall motility in fed/fasted states, and hydrodynamic and mechanical forces that act on the ingested food.
  • Stomach emptying rate, which controls the rate of absorption of nutrients, is highly related to the disintegration of foods.
  • Future research in this area is identified to increase our fundamental understanding of the food digestion process in the stomach as related to the food composition, material properties such as texture and microstructure, and chemical characteristics.
  • [MeSH-major] Digestion / physiology. Gastric Emptying / physiology. Stomach / metabolism


86. Masliakov VV, Barsukov VG, Dmitriev NV: [Surgical strategy for iatrogenic injuries of the spleen]. Vestn Khir Im I I Grek; 2010;169(2):90-1
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  • A retrospective investigation of 1226 case histories of patients operated on the stomach and duodenum was made.
  • The main cause of injuries to the spleen during operation was traction of the stomach when mobilizing it.

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  • (PMID = 20552799.001).
  • [ISSN] 0042-4625
  • [Journal-full-title] Vestnik khirurgii imeni I. I. Grekova
  • [ISO-abbreviation] Vestn. Khir. Im. I. I. Grek.
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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87. Shimizu M, Kawaguchi A, Nagao S, Hozumi H, Komoto S, Hokari R, Miura S, Hatsuse K, Ogata S: A case of intraductal papillary mucinous neoplasm of the pancreas rupturing both the stomach and duodenum. Gastrointest Endosc; 2010 Feb;71(2):406-12
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  • [Title] A case of intraductal papillary mucinous neoplasm of the pancreas rupturing both the stomach and duodenum.
  • BACKGROUND: Intraductal papillary mucinous neoplasm (IPMN) of the pancreas may extend to other organs.
  • However, it is rare for a histopathologically benign IPMN to rupture other organs, particularly multiple organs.
  • There has been no report of a benign IPMN rupturing both the stomach and duodenum.
  • CONCLUSIONS: We report a case of benign IPMN of the pancreas extending to two adjacent organs.
  • Intraluminal nodular growth was observed in the duodenal gland tissue, and abnormal growth was observed in the fistula to the stomach.
  • According to a literature review based on PubMed data up until March 2009, it is rare for a benign IPMN to penetrate two adjacent organs.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Carcinoma, Pancreatic Ductal / secondary. Carcinoma, Papillary / secondary. Duodenal Neoplasms / secondary. Pancreatic Neoplasms / pathology. Stomach Neoplasms / secondary
  • [MeSH-minor] Aged. Cholangiopancreatography, Endoscopic Retrograde / methods. Endosonography / methods. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness / pathology. Pancreaticoduodenectomy / methods. Rare Diseases. Risk Assessment. Rupture, Spontaneous / etiology. Rupture, Spontaneous / surgery. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19922925.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 22
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88. Ikuzawa M, Yasumasu S, Kobayashi K, Iuchi I: Cloning and expression of xP1-L, a new marker gene for larval surface mucous cells of tadpole stomach in Xenopus laevis. Gene Expr Patterns; 2007 Dec;8(1):12-8
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  • [Title] Cloning and expression of xP1-L, a new marker gene for larval surface mucous cells of tadpole stomach in Xenopus laevis.
  • In the present study, we examined the products of subtractive hybridization between tadpole and frog stomach cDNAs of Xenopus laevis in order to identify genes expressed specifically in the larval stomach epithelium.
  • In addition, in situ hybridization showed that xP1-L was localized to surface mucous cells of the larval stomach.
  • The H(+)/K(+)-ATPase beta subunit, a marker gene for manicotto gland cells in the tadpole stomach, was also detected at the same time.
  • The expression of xP1-L gradually decreased towards the metamorphic climax and disappeared after stage 61 when larval-type gastric epithelium is replaced by adult-type.
  • We found that xP1-L was never expressed in surface mucous cells of the adult-type stomach, and xP1, instead of xP1-L, was expressed.
  • Thus, xP1-L is a useful marker for larval surface mucous cells in tadpole stomach.
  • This is the first demonstration of a marker gene specific for the surface mucous cells of the larval stomach.
  • [MeSH-major] Gastric Mucosa / cytology. Larva / cytology. Xenopus Proteins / analysis. Xenopus laevis

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  • (PMID = 17928274.001).
  • [ISSN] 1567-133X
  • [Journal-full-title] Gene expression patterns : GEP
  • [ISO-abbreviation] Gene Expr. Patterns
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Intercellular Signaling Peptides and Proteins; 0 / Xenopus Proteins; 0 / xP1 protein, Xenopus; 0 / xP1-L protein, Xenopus
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89. Hu L, Lao SX, Tang CZ: Expression of bcl-2 oncogene in gastric precancerous lesions and its correlation with syndromes in traditional Chinese medicine. World J Gastroenterol; 2005 Jun 7;11(21):3293-6
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  • [Title] Expression of bcl-2 oncogene in gastric precancerous lesions and its correlation with syndromes in traditional Chinese medicine.
  • AIM: To observe the protein and mRNA expression of bcl-2 oncogene in gastric precancerous lesions (GPL) and to analyze its correlation with syndromes in traditional Chinese medicine (TCM).
  • METHODS: Sixty-seven patients with GPL confirmed by gastroscopy and pathology were studied, including 39 cases of moderate gastric mucosal dysplasia, 19 cases of severe gastric mucosa dysplasia, 9 cases of incomplete colon metaplasia.
  • In syndrome differentiation of TCM, 17 cases belonged to the syndrome of qi and yin deficiency of the spleen and stomach complicated by qi stagnation, 21 cases belonged to the syndrome of qi and yin deficiency of the spleen and stomach complicated by stomach heat, 29 cases belonged to the syndrome of qi and yin deficiency of the spleen and stomach complicated by blood stasis.
  • In moderate and severe gastric mucosal dysplasia and incomplete colon metaplasia, there was no difference in the expression of bcl-2 oncogene (P>0.05).
  • In different accompanying syndromes, the expression of protein and mRNA on bcl-2 oncogene increased gradually in the following order: deficiency of both qi and yin of the spleen and stomach accompanying qi stagnation-->stomach heat-->blood stasis.
  • In GPL, compared with accompanying blood stasis, there was an obvious difference in the expression of bcl-2 oncogene between the syndrome of qi and yin deficiency of the spleen and stomach and accompanying stomach heat, so did accompanying qi stagnation (the level of protein: chi(2) = 8.45, P<0.05; the level of mRNA: chi(2) = 7.35, P<0.05).
  • [MeSH-major] Medicine, Chinese Traditional. Precancerous Conditions / genetics. Proto-Oncogene Proteins c-bcl-2 / genetics. Stomach Neoplasms / genetics

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  • (PMID = 15929186.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-bcl-2
  • [Other-IDs] NLM/ PMC4316067
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90. Takeuchi K, Koyama M, Hayashi S, Aihara E: Prostaglandin EP receptor subtypes involved in regulating HCO(3)(-) secretion from gastroduodenal mucosa. Curr Pharm Des; 2010;16(10):1241-51
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  • By contrast, the gastric responses disappeared in EP1-knockout mice and were prevented by an EP1 antagonist but not other EP antagonists.
  • Furthermore, duodenal HCO(3)(-) secretion was stimulated by the EP3 and EP4 agonists, whereas gastric HCO(3)(-) secretion was increased only by the EP1 agonist.
  • In addition, the HCO(3)(-) stimulatory effect of sulprostone (an EP1/EP3 agonist) in the duodenum was inhibited by verapamil, a Ca(2+) antagonist, and enhanced by isobutyl- methylxanthine, a phosphodiesterase (PDE) inhibitor, but the response in the stomach was inhibited by verapamil and not affected by isobutylmethylxanthine.
  • In the mouse duodenum but not stomach, the response to PGE(2) was potentiated by both vinpocetine (a PDE1 inhibitor) and cilostamide (a PDE3 inhibitor).
  • These results suggest that the HCO(3)(-) stimulatory effect of PGE(2) in the duodenum is mediated by both EP3 and EP4 receptors, being coupled intracellularly with Ca(2+) and cAMP, while that in the stomach is mediated by EP1 receptors, coupled with Ca(2+).
  • [MeSH-major] Bicarbonates / metabolism. Duodenum / secretion. Gastric Mucosa / secretion. Intestinal Mucosa / secretion. Receptors, Prostaglandin E / physiology
  • [MeSH-minor] Animals. Mice. Prostaglandins E, Synthetic / agonists. Prostaglandins E, Synthetic / antagonists & inhibitors. Protective Agents / chemistry. Rats. Receptors, Prostaglandin E, EP2 Subtype. Stomach / drug effects

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  • (PMID = 20166995.001).
  • [ISSN] 1873-4286
  • [Journal-full-title] Current pharmaceutical design
  • [ISO-abbreviation] Curr. Pharm. Des.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Bicarbonates; 0 / Prostaglandins E, Synthetic; 0 / Protective Agents; 0 / Ptger2 protein, mouse; 0 / Receptors, Prostaglandin E; 0 / Receptors, Prostaglandin E, EP2 Subtype
  • [Number-of-references] 73
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91. Barros R, Pereira B, Duluc I, Azevedo M, Mendes N, Camilo V, Jacobs RJ, Paulo P, Santos-Silva F, van Seuningen I, van den Brink GR, David L, Freund JN, Almeida R: Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines. J Pathol; 2008 Aug;215(4):411-20
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  • [Title] Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines.
  • Helicobacter pylori infection induces intestinal metaplasia of the stomach, a preneoplastic lesion associated with an increased risk for gastric cancer development.
  • (1) the BMP pathway is crucial for normal intestinal differentiation and (2) there is an influx of BMP2 and BMP4-producing cells to the stomach upon Helicobacter pylori infection.
  • We evaluated the expression of key elements of the BMP pathway in human stomach specimens with IM.
  • [MeSH-major] Bone Morphogenetic Proteins / metabolism. Carcinoma / genetics. Gene Expression Regulation, Neoplastic. Homeodomain Proteins / genetics. Stomach Neoplasms / genetics. Transforming Growth Factor beta / metabolism
  • [MeSH-minor] Blotting, Western / methods. Bone Morphogenetic Protein 2. Bone Morphogenetic Protein 4. Cell Line, Tumor. Chromatin Immunoprecipitation. Humans. Immunohistochemistry. RNA Interference. RNA, Small Interfering / pharmacology. Reverse Transcriptase Polymerase Chain Reaction / methods. Smad1 Protein / metabolism. Smad4 Protein / genetics. Smad4 Protein / metabolism

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  • [Copyright] Copyright (c) 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
  • (PMID = 18498120.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / BMP2 protein, human; 0 / BMP4 protein, human; 0 / Bone Morphogenetic Protein 2; 0 / Bone Morphogenetic Protein 4; 0 / Bone Morphogenetic Proteins; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / RNA, Small Interfering; 0 / Smad1 Protein; 0 / Smad4 Protein; 0 / Transforming Growth Factor beta
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92. Albayrak F, Dursun H, Albayrak Y, Altas S, Uyanik A, Yildirim R: Inflammatory myofibroblastic tumor of the stomach in an adult woman: a rare intermittent cause of gastric outlet obstruction. Tumori; 2010 May-Jun;96(3):492-5
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  • [Title] Inflammatory myofibroblastic tumor of the stomach in an adult woman: a rare intermittent cause of gastric outlet obstruction.
  • BACKGROUND: Inflammatory myofibroblastic tumor is a neoplasm of intermediate biological potential that frequently recurs and rarely metastasizes.
  • CASE REPORT: We report a rare case of intermittent gastric outlet obstruction by an inflammatory myofibroblastic tumor of the cardia.
  • CONCLUSIONS: In order to avoid unnecessary aggressive therapy, gastric IMT should be taken into account when a gastric mass accompanied by the various clinical manifestations of IMT is found in an adult.
  • [MeSH-major] Gastric Outlet Obstruction / etiology. Neoplasms, Muscle Tissue / complications. Neoplasms, Muscle Tissue / pathology. Stomach Neoplasms / complications. Stomach Neoplasms / pathology

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  • (PMID = 20845815.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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93. Wendelken C, Nakhabenko D, Donohue SE, Carter CS, Bunge SA: "Brain is to thought as stomach is to ??": investigating the role of rostrolateral prefrontal cortex in relational reasoning. J Cogn Neurosci; 2008 Apr;20(4):682-93
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  • [Title] "Brain is to thought as stomach is to ??": investigating the role of rostrolateral prefrontal cortex in relational reasoning.

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  • (PMID = 18052787.001).
  • [ISSN] 0898-929X
  • [Journal-full-title] Journal of cognitive neuroscience
  • [ISO-abbreviation] J Cogn Neurosci
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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94. Bitziou E, O'Hare D, Patel BA: Simultaneous detection of pH changes and histamine release from oxyntic glands in isolated stomach. Anal Chem; 2008 Nov 15;80(22):8733-40
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  • [Title] Simultaneous detection of pH changes and histamine release from oxyntic glands in isolated stomach.
  • Real-time simultaneous detection of changes in pH and levels of histamine over the oxyntic glands of guinea pig stomach have been investigated.
  • Both sensors provided stable and reproducible responses that were qualitatively consistent with the signaling mechanism for acid secretion at the stomach.
  • These results highlight the power of this simultaneous detection technique in the monitoring and diagnosis of physiological significant signaling mechanisms and pathways.
  • [MeSH-major] Chemistry Techniques, Analytical / instrumentation. Gastric Mucosa / secretion. Histamine / analysis. Histamine Release. Stomach / anatomy & histology
  • [MeSH-minor] Acetylcholine / pharmacology. Animals. Boron / chemistry. Diamond / chemistry. Gastric Acid / secretion. Gastric Acidity Determination. Guinea Pigs. Hydrogen-Ion Concentration. Iridium / chemistry. Male. Microelectrodes. Neurons / drug effects. Neurons / physiology. Time Factors

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  • (PMID = 18947199.001).
  • [ISSN] 1520-6882
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 12030-49-8 / iridium oxide; 44448S9773 / Iridium; 7782-40-3 / Diamond; 820484N8I3 / Histamine; N9E3X5056Q / Boron; N9YNS0M02X / Acetylcholine
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95. Bi R, Sheng W, Wang J: Collision tumor of the stomach: gastric adenocarcinoma intermixed with gastrointestinal stromal tumor. Pathol Int; 2009 Dec;59(12):880-3
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  • [Title] Collision tumor of the stomach: gastric adenocarcinoma intermixed with gastrointestinal stromal tumor.
  • The synchronous occurrence of tumors of different histological types in the stomach is uncommon.
  • It is still not known whether such association represents an incidental coexistence or indicates a similar pathogenesis in the simultaneous development of tumors of different histological types in the same organ.
  • Gastroscopy showed a tumor at the juncture of the gastric fundus and corpus.
  • The tumor was composed of gastric adenocarcinoma and gastrointestinal stromal tumor, in which the two components were intermixed with each other.
  • To the authors' knowledge there are few reports of this extremely rare collision tumor association.
  • [MeSH-major] Adenocarcinoma / pathology. Gastrointestinal Stromal Tumors / pathology. Neoplasms, Multiple Primary / pathology. Stomach Neoplasms / pathology

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  • (PMID = 20021614.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha
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96. Sanchez Lihón J: [Metastasis of carcinoma of stomach cancer simulating primary ovarian tumor. Importance of frozen biopsies]. Rev Gastroenterol Peru; 2010 Oct-Dec;30(4):363-7
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  • [Title] [Metastasis of carcinoma of stomach cancer simulating primary ovarian tumor. Importance of frozen biopsies].
  • [Transliterated title] Metástasis de carcinoma de estómago que simula cancer primario de ovario. Importancia de la biopsia por congelación.
  • OBJECTIVE: The importance of frozen section in the Diagnosis and management of patients with ovarian tumors.
  • RESULTS: We report 9 cases of patients with ovary tumors.
  • The primary carcinoma was found during an operation for the ovarian tumor.
  • In these cases the diagnosis of krukenberg tumor was made intraoperatively by frozen section evaluation and the primary carcinoma were found in the stomach.
  • CONCLUSIONS: The results of the study of 9 patients with metastasis from gastric carcinoma simulating primary carcinoma of the ovary show us the importance of frozen section and the communication with the surgeon intraoperatively.
  • [MeSH-major] Ovarian Neoplasms / pathology. Ovarian Neoplasms / secondary. Stomach Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Frozen Sections. Humans. Middle Aged


97. Joksimovic N, Serafimoski V: Endosonographic diagnosis in submucosal tumours of the stomach. Prilozi; 2006 Jul;27(1):29-36
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  • [Title] Endosonographic diagnosis in submucosal tumours of the stomach.
  • ), of whom 64 were diagnosed with gastric cancer by EUS in which operability was determinate, and 94 pts. with gastric submucosal tumours.
  • Endoscopy and pathohistological examination were used in the primary detection and diagnosis of the gastric cancer, and EUS was a supplementary method that revealed additional information about the extent of the neoplasms.
  • The first group consisted of 94 pts (59.5%) with gastric submucosal lesions, and 64 pts (40.5%) with gastric cancer respectively.
  • The first group consisted of 94 pts. with submucosal tumours of the stomach.
  • The second group consisted of 64 pts (40.5%) with gastric cancer.
  • According to the EUS findings this group was divided into two subgroups: 45 operable patients and 19 inoperable patients with gastric cancer.
  • EUS proved a useful method for the diagnosis and follow-up of the patients with gastric cancer, as well as the staging of the tumour and follow-up during the post-operative period, and with submucosal tumours.

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  • (PMID = 16862063.001).
  • [ISSN] 0351-3254
  • [Journal-full-title] Prilozi
  • [ISO-abbreviation] Prilozi
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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98. Kim BM, Miletich I, Mao J, McMahon AP, Sharpe PA, Shivdasani RA: Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen. Development; 2007 Oct;134(20):3603-13
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  • [Title] Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen.
  • Barx1 is expressed selectively in fetal stomach mesenchyme and directs differentiation of overlying endoderm.
  • Recombinant tissue cultures and study of young mouse embryos previously suggested that Barx1 controls expression of secreted Wnt antagonists, which suppress endodermal Wnt signaling, to enable stomach epithelial differentiation.
  • We overcame mid-gestational lethality of Barx1(-/-) mouse embryos and report here the spectrum of anomalies in a distinctive and unprecedented model of gastrointestinal homeotic transformation.
  • Using various mouse models, we confirm the importance of attenuated Wnt signaling in stomach development and the role of Barx1 in suppressing endodermal Wnt activity.
  • Absence of Barx1 also results in fully penetrant defects in positioning and expansion of the spleen, an organ that originates within the mesothelial lining of the stomach.
  • Mouse spleen development relies on several homeodomain transcriptional regulators that are expressed in the spleen primordium.
  • [MeSH-major] Homeodomain Proteins. Morphogenesis. Spleen. Stomach. Transcription Factors

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  • (PMID = 17855428.001).
  • [ISSN] 0950-1991
  • [Journal-full-title] Development (Cambridge, England)
  • [ISO-abbreviation] Development
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0200709; United States / NIDDK NIH HHS / DK / R01DK61139; United States / NINDS NIH HHS / NS / R01NS033642
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Barx1 protein, mouse; 0 / Homeodomain Proteins; 0 / Transcription Factors; 0 / WT1 Proteins; 0 / Wnt Proteins
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99. Turner A, Pathirana S, Daley A, Gill PS: Sri Lankan tsunami refugees: a cross sectional study of the relationships between housing conditions and self-reported health. BMC Int Health Hum Rights; 2009;9:16
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  • After controlling for gender, age and marital status, living in a transitional camp compared to a housing project was found to be a significant risk factor for the following symptoms; coughs OR: 3.53 (CI: 2.11-5.89), stomach ache 4.82 (2.19-10.82), headache 5.20 (3.09-8.76), general aches and pains 6.44 (3.67-11.33) and feeling generally unwell 2.28 (2.51-7.29).
  • Within transitional camp data, the only condition shown to be a significant risk factor for any symptom was household population density, which increased the risk of stomach aches 1.40 (1.09-1.79) and headaches 1.33 (1.01-1.77).

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  • (PMID = 19653917.001).
  • [ISSN] 1472-698X
  • [Journal-full-title] BMC international health and human rights
  • [ISO-abbreviation] BMC Int Health Hum Rights
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2729729
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100. Moro E, Crema F, Dandolo C, De Ponti F, Frigo G: Effect of muscarinic receptor blockade on canine gastric tone and compliance in vivo. Pharmacol Res; 2005 Apr;51(4):289-96
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  • [Title] Effect of muscarinic receptor blockade on canine gastric tone and compliance in vivo.
  • Muscarinic pathways are involved in maintaining gastric tone during fasting and atropine is known to decrease gastric tone via blockade of a tonic vagal cholinergic input.
  • Our aim was to assess the role of different muscarinic receptors in modulating canine gastric tone and compliance in vivo by using "selective" muscarinic receptor antagonists (telenzepine, AF-DX 116 and 4-DAMP for M1, M2, and M3 receptors, respectively) and the non-selective muscarinic receptor antagonist atropine.
  • In four fasting, conscious dogs, we characterized the pressure-volume relationship in the proximal stomach by using a barostat.
  • Atropine (100 microg kg-1) immediately decreased baseline gastric tone, i.e. relaxed the stomach (Deltavolume at 2 mmHg=236+/-15 ml; P<0.05), and significantly (P<0.01) shifted the pressure-volume curve to the left.
  • AF-DX 116 at the lower dose (422 microg kg-1) had no effect on baseline gastric tone or the gastric pressure-volume curve, whereas the higher dose (2532 microg kg-1) significantly shifted the pressure-volume curve to the left (P<0.01), but did not increase baseline gastric volume.
  • Finally, 4-DAMP (13.5, 45, 135 microg kg-1) immediately decreased baseline gastric tone (Deltavolume at 2 mmHg=97+/-29 ml, 110+/-35 ml and 155+/-21 ml, respectively) and significantly shifted the pressure-volume curve to the left (P<0.01).
  • We conclude that muscarinic pathways are involved in modulating canine gastric tone and compliance during fasting: M3 receptors seem to play a key role in excitatory pathways, whereas the shift of pressure-volume curve to the right observed with the lowest dose of telenzepine is consistent with the existence of M1 receptors on inhibitory pathways.
  • [MeSH-major] Gastric Emptying / drug effects. Muscarinic Antagonists / pharmacology. Muscle Tonus / drug effects. Muscle Tonus / physiology. Receptors, Muscarinic / physiology

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  • (PMID = 15683741.001).
  • [ISSN] 1043-6618
  • [Journal-full-title] Pharmacological research
  • [ISO-abbreviation] Pharmacol. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Muscarinic Antagonists; 0 / Receptors, Muscarinic
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