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1. Dickson P, McEntee M, Vogler C, Le S, Levy B, Peinovich M, Hanson S, Passage M, Kakkis E: Intrathecal enzyme replacement therapy: successful treatment of brain disease via the cerebrospinal fluid. Mol Genet Metab; 2007 May;91(1):61-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We studied IT enzyme replacement therapy with recombinant human iduronidase (rhIDU) in canine mucopolysaccharidosis I (MPS I, Hurler syndrome), a lysosomal storage disorder with brain and meningeal involvement.
  • Monthly or quarterly IT treatment regimens with rhIDU achieved supranormal iduronidase enzyme levels in the brain, spinal cord, and spinal meninges.
  • All regimens normalized total brain glycosaminoglycan (GAG) storage and reduced spinal meningeal GAG storage by 58-70%.

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  • (PMID = 17321776.001).
  • [ISSN] 1096-7192
  • [Journal-full-title] Molecular genetics and metabolism
  • [ISO-abbreviation] Mol. Genet. Metab.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / NS054242-01A1; United States / NINDS NIH HHS / NS / R01 NS054242; United States / NINDS NIH HHS / NS / R01 NS054242-01A1
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glycosaminoglycans; 0 / Recombinant Proteins; EC 3.2.1.76 / Iduronidase
  • [Other-IDs] NLM/ NIHMS255556; NLM/ PMC3009387
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2. Engelhard HH, Villano JL, Porter KR, Stewart AK, Barua M, Barker FG, Newton HB: Clinical presentation, histology, and treatment in 430 patients with primary tumors of the spinal cord, spinal meninges, or cauda equina. J Neurosurg Spine; 2010 Jul;13(1):67-77
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  • [Title] Clinical presentation, histology, and treatment in 430 patients with primary tumors of the spinal cord, spinal meninges, or cauda equina.
  • OBJECT Patients having a primary tumor of the spinal cord, spinal meninges or cauda equina, are relatively rare.
  • METHODS Extensive information on individuals diagnosed (in the year 2000) as having a primary CNS neoplasm was prospectively collected in a Patient Care Evaluation Study conducted by the Commission on Cancer of the American College of Surgeons.
  • [MeSH-major] Cauda Equina / pathology. Meningeal Neoplasms / pathology. Meningeal Neoplasms / surgery. Peripheral Nervous System Neoplasms / pathology. Peripheral Nervous System Neoplasms / surgery. Spinal Cord Neoplasms / pathology. Spinal Cord Neoplasms / surgery

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  • (PMID = 20594020.001).
  • [ISSN] 1547-5646
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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3. Feiden W, Feiden S: [Histopathology of space-occupying lesions of the spine]. Radiologe; 2006 Dec;46(12):1029-34
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  • The first step in diagnosing spinal lesions is to define the anatomical location, especially via magnetic resonance tomography, which is also helpful for histopathologists.
  • However, definite diagnosis is based on histologic and cytologic examinations especially in the case of fine-needle biopsies.
  • In this short review the principal histopathologic diagnoses of primary and secondary tumors and tumor-like lesions of the spine itself, the epidural space, the spinal meninges and nerve roots, and the spinal cord are addressed.
  • The significance of immunohistochemistry for differential diagnosis or, in cases of spinal metastasis, for determination of the primary is discussed.
  • [MeSH-major] Spinal Cord Neoplasms / pathology. Spinal Neoplasms / pathology
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Humans. Spinal Cord / pathology. Spine / pathology

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  • [Cites] Pathologe. 1997 Jan;18(1):107-10 [9157399.001]
  • (PMID = 17041775.001).
  • [ISSN] 0033-832X
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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4. Ho CL, Deruytter MJ: Dual occurrence of pineal germinoma and testicular seminoma. Case report and review of the literature. Pediatr Neurosurg; 2006;42(1):38-44
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  • Endoscopic ventriculostomy was preferred in our case, thus avoiding iatrogenic peritoneal seeding, but spinal metastasis was unavoidable.
  • Metastatic infiltration of the ventricular system and spinal meninges is the commonest mode of spread.
  • As far as we know there are only a handful of reported cases of dual occurrence of two primary germ cell tumors (GCT), i.e. gonadal seminoma and pineal germinoma with spinal seeding.

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  • [Copyright] Copyright 2006 S. Karger AG, Basel
  • [CommentIn] Pediatr Neurosurg. 2009;45(2):160 [19321956.001]
  • (PMID = 16357500.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 38
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5. Jones KB, Myers L, Judge DP, Kirby PA, Dietz HC, Sponseller PD: Toward an understanding of dural ectasia: a light microscopy study in a murine model of Marfan syndrome. Spine (Phila Pa 1976); 2005 Feb 1;30(3):291-3
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  • STUDY DESIGN: Light microscopy study of the lumbar spinal meninges of a murine model of Marfan syndrome.
  • OBJECTIVE: Characterize the pathology of the lumbosacral meninges in Marfan syndrome, seeking clues to the pathophysiology behind dural ectasia.
  • The etiology of dural ectasia is unknown, but is conjectured to be related to constitutionally weak spinal dura.

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  • (PMID = 15682009.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Microfilament Proteins; 0 / Transforming Growth Factor beta; 0 / fibrillin; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9
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6. Larrosa D, Vázquez JL, Mateo I, Infante J: [Familial spontaneous intracranial hypotension]. Neurologia; 2009 Sep;24(7):485-7
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  • [Transliterated title] Síndrome de hipotensión intracraneal espontánea de presentación familiar.
  • Spontaneous intracranial hypotension is caused by spinal cerebrospinal fluid leaks and evidence for an underlying generalized connective tissue disorder is found in about two thirds of patients.
  • DISCUSSION: These familial cases of spontaneous SIH suggest that certain underlying genetic susceptibility, probably linked to lower resistance of the spinal meninges, could favor the development of spontaneous intracranial hypotension.
  • [MeSH-major] Intracranial Hypotension / diagnosis. Intracranial Hypotension / genetics. Intracranial Hypotension / physiopathology
  • [MeSH-minor] Female. Humans. Magnetic Resonance Imaging. Meninges / metabolism. Middle Aged. Young Adult

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  • (PMID = 19921558.001).
  • [ISSN] 0213-4853
  • [Journal-full-title] Neurología (Barcelona, Spain)
  • [ISO-abbreviation] Neurologia
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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7. Deinsberger R, Regatschnig R, Kaiser B, Bankl HC: Spinal leptomeningeal metastases from prostate cancer. J Neurooncol; 2006 Feb;76(3):293-7
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  • [Title] Spinal leptomeningeal metastases from prostate cancer.
  • OBJECTIVE: Prostate cancer is a well known cause of spinal column metastases; however, an intradural location is extremely rare.
  • PATIENT AND RESULTS: We review the known cases of spinal leptomeningeal prostate cancer spread, including our patient, who developed paraparesis over 6 weeks, 3 years after prostate cancer was diagnosed.
  • Following surgical decompression and resection, the patient additionally received radiation therapy of the spinal meninges and antihormonal treatment.
  • CONCLUSION: Spinal leptomeningeal metastases occur at a late stage of systemic disease, and the prognosis is generally poor.
  • Surgery should be performed in selected cases of spinal leptomeningeal metastases, in patients who are still ambulatory with controlled systemic disease, and should be followed by adjuvant therapy.
  • [MeSH-major] Carcinoma / secondary. Meningeal Neoplasms / secondary. Prostatic Neoplasms / pathology. Spinal Cord Neoplasms / secondary

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  • (PMID = 16151594.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen
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8. Wrzosek M, Konar M, Vandevelde M, Oevermann A: Cerebral extension of steroid-responsive meningitis arteritis in a boxer. J Small Anim Pract; 2009 Jan;50(1):35-7
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  • In addition, chronic inflammation and arterial stenosis was found in the spinal meninges.
  • A diagnosis of steroid-responsive meningitis arteritis was made.
  • The massive extension into the meninges and ventricular system of the forebrain has not been described previously in dogs with steroid-responsive meningitis arteritis and should be considered in the differential diagnosis when an intracranial suppurative infection is suspected.
  • [MeSH-major] Dog Diseases / diagnosis. Meningitis / veterinary. Polyarteritis Nodosa / veterinary
  • [MeSH-minor] Animals. Anticonvulsants / administration & dosage. Brain / pathology. Diagnosis, Differential. Diazepam / administration & dosage. Dogs. Euthanasia, Animal. Magnetic Resonance Imaging / veterinary. Male. Steroids. Switzerland

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  • [ErratumIn] J Small Anim Pract. 2009 Jun;50(6):319
  • (PMID = 19161508.001).
  • [ISSN] 0022-4510
  • [Journal-full-title] The Journal of small animal practice
  • [ISO-abbreviation] J Small Anim Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anticonvulsants; 0 / Steroids; Q3JTX2Q7TU / Diazepam
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9. Quigley RR, Knowles KE, Johnson GC: Disseminated chlorellosis in a dog. Vet Pathol; 2009 May;46(3):439-43
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  • At the postmortem examination, the lingual mass, regions of the lungs and hilar lymph nodes, liver, mesenteric and sublumbar lymph nodes, and spinal meninges had pronounced green discoloration.
  • Histologically, pyogranulomatous inflammation and algal organisms were found in the tongue, spinal meninges, hilar and mesenteric lymph nodes, liver, and lung.
  • [MeSH-minor] Animals. Dogs. Female. Meninges / microbiology. Spinal Cord / microbiology. Spinal Cord / pathology. Tongue / microbiology. Tongue / pathology

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  • (PMID = 19176504.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Koch HJ, Roeber S, Zimmermann UW, Schäfer C, Villarrubia V, Kuchelmeister K, Schachenmayr W, Bogdahn U, Steinbrecher A: [Spinal and cerebral leptomeningeal seeding from a melanocytoma of the cerebello-pontine angle]. Wien Med Wochenschr; 2005 Aug;155(15-16):360-4
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  • [Title] [Spinal and cerebral leptomeningeal seeding from a melanocytoma of the cerebello-pontine angle].
  • [Transliterated title] Spinale und zerebrale Meningeosis eines sekundär malignisierten Melanozytoms des Kleinhirnbrückenwinkels.
  • Meningeal melanocytoma refers to the uncommon clinical appearance of a generally benign tumour deriving from leptomeningeal melanocytes.
  • After surgical resection of the melancytoma in the left skull base and of a first local recurrence five years later, a second local recurrence occurred 6 years after diagnosis, with intracerebral and spinal meningeal seeding.
  • [MeSH-major] Cerebellopontine Angle. Melanocytes / pathology. Melanoma. Meningeal Neoplasms. Meninges. Neoplasm Seeding
  • [MeSH-minor] Administration, Oral. Adult. Antineoplastic Agents, Alkylating / administration & dosage. Antineoplastic Agents, Alkylating / therapeutic use. Arachnoid. Cerebellar Diseases / diagnosis. Cerebellar Neoplasms / diagnosis. Combined Modality Therapy. Dacarbazine / analogs & derivatives. Dacarbazine / therapeutic use. Diagnosis, Differential. Disease Progression. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local. Pia Mater. Radiotherapy Dosage. Time Factors

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  • (PMID = 16160923.001).
  • [ISSN] 0043-5341
  • [Journal-full-title] Wiener medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Wien Med Wochenschr
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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11. Deinsberger R, Regatschnig R, Kaiser B, Bankl HC: Spinal leptomeningeal metastases from prostate cancer. Acta Neurochir (Wien); 2006 Apr;148(4):467-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal leptomeningeal metastases from prostate cancer.
  • OBJECTIVE: Prostate cancer is a well known cause of spinal column metastases; however, an intradural location is extremely rare.
  • PATIENT AND RESULTS: We review the known cases of spinal leptomeningeal prostate cancer spread, including our patient, who developed paraparesis over 6 weeks, 3 years after prostate cancer was diagnosed.
  • Following surgical decompression and resection, the patient additionally received radiation therapy of the spinal meninges and antihormonal treatment.
  • CONCLUSION: Spinal leptomeningeal metastases occur at a late stage of systemic disease, and the prognosis is generally poor.
  • Surgery should be performed in selected cases of spinal leptomeningeal metastases, in patients who are still ambulatory with controlled systemic disease, and should be followed by adjuvant therapy.
  • [MeSH-major] Carcinoma / secondary. Meningeal Neoplasms / secondary. Prostatic Neoplasms / pathology. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Arachnoid / pathology. Arachnoid / physiopathology. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness / diagnosis. Neoplasm Invasiveness / physiopathology. Neurosurgical Procedures. Paraparesis / diagnosis. Paraparesis / etiology. Paraparesis / physiopathology. Pia Mater / pathology. Pia Mater / physiopathology. Radiotherapy. Spinal Cord / pathology. Spinal Cord / physiopathology. Subarachnoid Space / pathology. Subarachnoid Space / physiopathology. Treatment Outcome

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  • [RetractionIn] Acta Neurochir (Wien). 2010 May;152(5):929 [20177719.001]
  • (PMID = 16322903.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Retracted Publication
  • [Publication-country] Austria
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12. Zhang GX, Li KA, Zhao JL, Zhang F, Hu YS, Li YJ: [MRI monitoring of cerebral spinal fluid metastasis in rabbit model]. Zhonghua Yi Xue Za Zhi; 2008 Dec 23;88(47):3369-73
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  • [Title] [MRI monitoring of cerebral spinal fluid metastasis in rabbit model].
  • OBJECTIVE: To establish a rabbit model of cerebral spinal flow metastasis, to analyze the growth rate of tumor, and to investigate the value of MRI in monitoring the biology of tumor compared with pathology.
  • The rabbits were killed after the last MRI scan with their spinal cords, spinal meninges, and tumor taken out to undergo microscopy. RESULTS:.
  • (1) MRI plain scan showed that in the experimental group 2 nodi in the medulla and 1 nodes in the cervical spinal cord were found with low signal on T(1)WI and high signal on T(2)WI; and FLAIR imaging showed local lesions with medial signal in 6 rabbits (25%).
  • And no abnormal signs were seen in the control group. (2) MRI enhancement showed that in the experimental group the images of 15 rabbit models were enhanced markedly with irregular thickening of meninges or nodules at the subarachnoid space on T(1)WI, positive signs were confirmed on FLAIR sequence in 16 of the 24 rabbits, and positive signs were noted on DCE-MRI scanning in 18 of the 24 rabbits (75%).
  • Microscopy showed thickened of meninges and spinal meninges in 20 of the 24 rabbits of the experimental group and spinal cord metastasis in 22 rabbits.
  • [MeSH-major] Magnetic Resonance Imaging. Neoplasm Transplantation / pathology. Neoplasms, Experimental / pathology. Spinal Cord Neoplasms / cerebrospinal fluid. Spinal Cord Neoplasms / secondary

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  • (PMID = 19257973.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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13. Guilfoyle MR, Khan S, Helmy A, Jalloh I, Trivedi S, Trivedi R, Kirkpatrick PJ: Spinal intradural haemorrhage in a patient with Wegener's Granulomatosis. Clin Neurol Neurosurg; 2010 May;112(4):341-3
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  • [Title] Spinal intradural haemorrhage in a patient with Wegener's Granulomatosis.
  • We propose involvement of the spinal meninges in the systemic vasculitis as the cause of haemorrhage.
  • [MeSH-major] Granulomatosis with Polyangiitis / complications. Hematoma, Subdural / surgery. Spinal Diseases / surgery


14. Lokuhetty MD, Wijesinghe HD, Weerasundera B, Dayapala A: Iatrogenic Aspergillus infection of the central nervous system in a pregnant woman. Indian J Pathol Microbiol; 2009 Jul-Sep;52(3):427-9
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  • A healthy postnatal woman succumbed to fulminant iatrogenic Aspergillus infection of the central nervous system, following accidental inoculation into the subarachnoid space at spinal anesthesia, during an outbreak of Aspergillus meningitis in Sri Lanka.
  • The spinal parenchyma was resistant to fungal invasion in spite of the heavy growth within the spinal meninges and initial inoculation at spinal level.
  • [MeSH-major] Aspergillus fumigatus / isolation & purification. Iatrogenic Disease. Neuroaspergillosis / diagnosis. Neuroaspergillosis / pathology. Pregnancy Complications, Infectious / microbiology

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  • (PMID = 19679983.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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15. Eyenga VC, Ngah JE, Atangana R, Etom E, Ngowe MN, Bassong Y, Oyono JL, Sosso M: [Central nervous system tumours in Cameroon: histopathology and demography]. Sante; 2008 Jan-Mar;18(1):39-42
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  • In all, 74.9% (n=173) of the tumours were intracranial and 25.1% (n=58) spinal; 167 (72.3%) were the primary site and 64 (27.7%) metastatic.
  • Primary tumors were malignant in 34.2% (n=12) of the children and benign in 65.8% (n=23); among adults 22.7% (n=30) were malignant and 77.3% (n=102) benign.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Astrocytoma / epidemiology. Astrocytoma / pathology. Brain / pathology. Cameroon. Child. Child, Preschool. Female. Humans. Infant. Infant, Newborn. Male. Meninges / pathology. Middle Aged. Neoplasm Staging

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  • (PMID = 18684690.001).
  • [ISSN] 1157-5999
  • [Journal-full-title] Santé (Montrouge, France)
  • [ISO-abbreviation] Sante
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
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16. Dickson PI, Hanson S, McEntee MF, Vite CH, Vogler CA, Mlikotic A, Chen AH, Ponder KP, Haskins ME, Tippin BL, Le SQ, Passage MB, Guerra C, Dierenfeld A, Jens J, Snella E, Kan SH, Ellinwood NM: Early versus late treatment of spinal cord compression with long-term intrathecal enzyme replacement therapy in canine mucopolysaccharidosis type I. Mol Genet Metab; 2010 Oct-Nov;101(2-3):115-22
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  • [Title] Early versus late treatment of spinal cord compression with long-term intrathecal enzyme replacement therapy in canine mucopolysaccharidosis type I.
  • Spinal cord compression develops in MPS I patients due in part to dural and leptomeningeal thickening from accumulated glycosaminoglycans (GAG).
  • We tested long-term and every 3-month intrathecal (IT) and weekly IV rhIDU in MPS I dogs age 12-15months (Adult) and MPS I pups age 2-23days (Early) to determine whether spinal cord compression could be reversed, stabilized, or prevented.
  • IT + IV rhIDU (Adult and Early) led to very high iduronidase levels in cervical, thoracic, and lumber spinal meninges (3600-29,000% of normal), while IV rhIDU alone (Adult and Early) led to levels that were 8.2-176% of normal.
  • GAG storage was significantly reduced from untreated levels in spinal meninges of IT + IV Early (p<.001), IT+IV Adult (p=.001), 0.58mg/kg IV Early (p=.002) and 1.57mg/kg IV Early (p<.001) treatment groups.
  • Treatment of dogs shortly after birth with IT+IV rhIDU (IT + IV Early) led to normal to near-normal GAG levels in the meninges and histologic absence of storage vacuoles.
  • Lysosomal storage was reduced in spinal anterior horn cells in 1.57mg/kg IV Early and IT + IV Early animals.
  • All dogs in IT + IV Adult and IV Adult groups had compression of their spinal cord at 12-15months of age determined by magnetic resonance imaging and was due to protrusion of spinal disks into the canal.
  • High-dose IV rhIDU from birth (1.57mg/kg weekly) appeared to prevent cord compression due to protrusion of spinal disks.
  • [MeSH-major] Enzyme Replacement Therapy / veterinary. Iduronidase / therapeutic use. Mucopolysaccharidosis I / drug therapy. Mucopolysaccharidosis I / veterinary. Spinal Cord Compression / drug therapy. Spinal Cord Compression / veterinary
  • [MeSH-minor] Animals. Dogs. Humans. Injections, Spinal. Magnetic Resonance Imaging / veterinary. Spinal Cord / pathology

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
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  • [ISSN] 1096-7206
  • [Journal-full-title] Molecular genetics and metabolism
  • [ISO-abbreviation] Mol. Genet. Metab.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / R56 DK066448; United States / NCRR NIH HHS / RR / P40 RR002512; United States / NIDDK NIH HHS / DK / R01 DK066448; United States / NINDS NIH HHS / NS / R01 NS054242; United States / NCRR NIH HHS / RR / RR002512; United States / NIDDK NIH HHS / DK / DK066448; United States / NINDS NIH HHS / NS / NS054242; United States / NIH HHS / OD / P40 OD010939
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.2.1.76 / Iduronidase
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17. Sioka C, Kyritsis AP: Chemotherapy, hormonal therapy, and immunotherapy for recurrent meningiomas. J Neurooncol; 2009 Mar;92(1):1-6
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  • Meningioma is a common intracranial tumor, originating from the meninges of the skull or spinal canal.
  • Most meningiomas are benign tumors, however atypical or anaplastic tumors can be found in 6% of cases.
  • Patients with asymptomatic small benign meningiomas can be followed without therapy, but in symptomatic patients complete surgical resection should be performed.
  • Antiprogesterone treatment can also be considered in recurrent benign meningiomas.
  • Immunotherapy with interferon-alpha and chemotherapy should be reserved for all cases of recurrent meningiomas (benign, atypical, and malignant) when all the standard therapies have failed or contraindicated.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Immunotherapy / methods. Meningeal Neoplasms / therapy. Meningioma / therapy. Neoplasm Recurrence, Local / therapy

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  • (PMID = 19023520.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Hormonal
  • [Number-of-references] 43
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18. Reina MA, Prats-Galino A, Sola RG, Puigdellívol-Sánchez A, Arriazu Navarro R, De Andrés JA: [Structure of the arachnoid layer of the human spinal meninges: a barrier that regulates dural sac permeability]. Rev Esp Anestesiol Reanim; 2010 Oct;57(8):486-92
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  • [Title] [Structure of the arachnoid layer of the human spinal meninges: a barrier that regulates dural sac permeability].
  • [Transliterated title] Morfología de la lámina aracnoidea espinal humana. Barrera que limita la permeabilidad del saco dural.
  • [MeSH-major] Arachnoid / ultrastructure. Spinal Cord / ultrastructure

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  • (PMID = 21033455.001).
  • [ISSN] 0034-9356
  • [Journal-full-title] Revista española de anestesiología y reanimación
  • [ISO-abbreviation] Rev Esp Anestesiol Reanim
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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19. Matsuda K, Sato N, Sakaguchi K, Taguchi K, Taniyama H: Suprascapular nerve paralysis due to streptococcal meningoradiculitis in a cow. J Vet Med Sci; 2008 Dec;70(12):1349-51
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  • Histological examination revealed necrosuppurative lesions with Gram-positive cocci arranged in chains in multiple organs, including the cardiac valves, lungs, muscles, joints, brain, cerebral and spinal meninges.
  • Spinal meningitis progressed into the roots of the right 6th to 8th cervical nerves.






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