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1. Karonidis A, Rigby HS, Orlando A: Collagenosis Nuchae: a case report of a rare and often misdiagnosed condition. J Plast Reconstr Aesthet Surg; 2007;60(3):320-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CN is a rare benign soft tissue tumour that arises from the posterior cervical subcutaneous tissue with predilection for the interscapular and paraspinal regions.
  • The true incidence of CN is probably higher than recognised and CN should be in the differential diagnosis of head and neck lesions.
  • Histological examination is required for the diagnosis.
  • Careful total excision provides cure and accurate diagnosis.
  • [MeSH-major] Fibroma / diagnosis. Head and Neck Neoplasms / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 17293293.001).
  • [ISSN] 1748-6815
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 10
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2. Al-Otaibi M, Lach B, Al Shail E: December 2004: one-year-old girl with aggressive skull tumor. Brain Pathol; 2005 Apr;15(2):171-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] December 2004: one-year-old girl with aggressive skull tumor.
  • December 2004. Twelve-month old girl presented with recurrent subcutaneous lesion in the left parietal region, one year after excision of a "benign" tumor.
  • An MRI demonstrated left temporo-parietal skull tumor infiltrating the soft tissue, surrounding craniotomy flap, and extending to the brain parenchyma.
  • Biopsy revealed biphasic neoplasm displaying nests of poorly differentiated neuroblastic cells positive for synaptophysin and pigmented cuboidal epithelioid cell positive for keratins, epithelial membrane antigen and MHB-45.
  • Interestingly, cell with the neuroblastic immunophenotype displayed 80% nuclear MIB-1 reactivity indicating that the aggressiveness of the neoplasm was confined mostly to this pattern of differentiation.
  • The overall histological features are consistent with a rare malignant variant of a melanotic neuroectodermal tumor of infancy.
  • [MeSH-major] Neoplasm Recurrence, Local / pathology. Neuroectodermal Tumor, Melanotic / pathology. Parietal Bone / pathology. Skull Neoplasms / pathology
  • [MeSH-minor] Brain Neoplasms / secondary. Diagnosis, Differential. Fatal Outcome. Female. Humans. Immunohistochemistry. Infant. Magnetic Resonance Imaging. Soft Tissue Neoplasms / secondary. Tomography, X-Ray Computed

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  • (PMID = 15912891.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
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3. Bergman S, Brownlee NA, Geisinger KR, Ward WG, Pettenati MJ, Koty P, Ellis E, Beaty MW, Kilpatrick SE: Diagnostic pitfalls associated with fine-needle aspiration biopsy in a patient with the myxoid variant of monophasic fibrous synovial sarcoma. Diagn Cytopathol; 2006 Nov;34(11):761-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Synovial sarcoma (SS) is one of the most common soft tissue tumors that typically presents in the extremities of young adults, but may occur at any site and affect children during the first decade.
  • A fine-needle aspiration biopsy of an 8 cm subcutaneous mass was performed revealing a myxoid spindle cell neoplasm.
  • The cytologic differential diagnosis included a myxoid neurofibroma, neurothekeoma, and a myxoid sarcoma.
  • Examination of the tissue by fluorescence in situ hybridization confirmed the presence of characteristic SS SYT gene rearrangement at chromosome 18q11.2.
  • We report the cytologic features of a myxoid monophasic fibrous SS, and discuss its distinction from other benign and malignant myxoid soft tissue neoplasms.
  • [MeSH-major] Ganglion Cysts / pathology. Sarcoma, Synovial / diagnosis. Sarcoma, Synovial / pathology

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  • [Copyright] (C) 2006 Wiley-Liss, Inc.
  • (PMID = 17121200.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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4. Kim HJ, Lee KY, Kim YW: Case report: Imaging features of perianal leiomyoma. Br J Radiol; 2009 Aug;82(980):e168-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A leiomyoma is a benign mesenchymal neoplasm that usually develops where smooth muscle is present.
  • It was confirmed as a deep soft-tissue leiomyoma on pathology.
  • [MeSH-major] Anal Canal. Anus Neoplasms / diagnosis. Leiomyoma / diagnosis
  • [MeSH-minor] Adult. Contrast Media. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging / methods

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  • [ErratumIn] Br J Radiol. 2010 Jan;83(985):88. Lee, G H [corrected to Lee, K Y]
  • (PMID = 19592401.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media
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5. Anagnostopoulos G, Sakorafas GH, Grigoriadis K, Kostopoulos P: Malignant fibrous histiocytoma of the liver: a case report and review of the literature. Mt Sinai J Med; 2005 Jan;72(1):50-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Malignant fibrous histiocytoma (MFH) is a common soft tissue sarcoma, usually occurring in the extremities.
  • MFH of the liver is an extremely rare neoplasm, with only 28 cases reported in the international literature since 1985.
  • The tumor was located in the right lobe of the liver and measured 12 ' 8 cm.
  • Most of the tumor cells and giant cells were vimentin and a 1-antichymotrypsin positive.
  • [MeSH-major] Histiocytoma, Benign Fibrous / diagnosis. Liver Neoplasms / diagnosis. Sarcoma / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Histological Techniques. Humans. Rare Diseases. Tomography, X-Ray Computed


6. Riddle ND, Yamauchi H, Caracciolo JT, Cheong D, Khakpour N, Bui MM: Giant cell tumor of the anterior rib masquerading as a breast mass: a case report and review of current literature. Cases J; 2010;3:51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumor of the anterior rib masquerading as a breast mass: a case report and review of current literature.
  • INTRODUCTION: Giant cell tumor (GCT) is an aggressive, but usually benign bone neoplasm most commonly arising in the metaphysis/epiphyses of long bones.
  • While they are categorized as benign tumors, they can be locally aggressive and clinically have metastatic potential.
  • The most common locations of this tumor include the distal femur, proximal tibia, and distal radius.
  • Further evaluation revealed the mass to be an expansile rib lesion with extraosseous soft tissue invasion.
  • CONCLUSION: The histological features of bland mononuclear and multinucleated giant cells along with the lack of any additional mesenchymal elements led to the diagnosis of giant cell tumor.
  • Resection of tumor was performed.
  • This case is important as it shows where the physician must keep this diagnosis in mind whenever a deeply located breast mast is present.

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  • [Cites] Skeletal Radiol. 1992;21(7):482-8 [1439904.001]
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  • (PMID = 20205847.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2825505
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7. Bahamonde L, Catalan J: Bone tumors around the knee: risks and benefits of arthroscopic procedures. Arthroscopy; 2006 May;22(5):558-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although most primary bone tumors and soft tissue tumors arise around the knee joint, many patients with tumoral conditions attribute their symptoms to traumatic events.
  • Arthroscopy is the preferred method for diagnosis and treatment of knee joint disease, but even a minimally invasive procedure may have adverse consequences in the presence of an unsuspected neoplasm.
  • In addition, arthroscopy is a useful adjunct during surgical treatment of patients with certain juxta-articular benign bone tumors.
  • [MeSH-major] Arthroscopy. Bone Neoplasms / surgery. Knee Joint
  • [MeSH-minor] Biopsy. Humans. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / surgery

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  • (PMID = 16651168.001).
  • [ISSN] 1526-3231
  • [Journal-full-title] Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
  • [ISO-abbreviation] Arthroscopy
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 29
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8. Wu J, Brinker DA, Haas M, Montgomery EA, Argani P: Primary alveolar soft part sarcoma (ASPS) of the breast: report of a deceptive case with xanthomatous features confirmed by TFE3 immunohistochemistry and electron microscopy. Int J Surg Pathol; 2005 Jan;13(1):81-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary alveolar soft part sarcoma (ASPS) of the breast: report of a deceptive case with xanthomatous features confirmed by TFE3 immunohistochemistry and electron microscopy.
  • Alveolar soft part sarcoma (ASPS) is a rare neoplasm that most commonly presents in the lower extremities.
  • The cells labeled strongly for the histiocytic marker CD68, suggesting a benign macrophage-rich lesion.
  • The diagnosis of ASPS was confirmed by electron microscopy, which revealed characteristic membrane-bound rhomboidal crystals, as well as by nuclear labeling for TFE3 protein by immunohistochemistry.
  • [MeSH-major] Breast Neoplasms / pathology. DNA-Binding Proteins. Deoxycytidine / analogs & derivatives. Sarcoma / secondary. Soft Tissue Neoplasms / pathology. Transcription Factors. Xanthomatosis / pathology
  • [MeSH-minor] Adult. Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Antimetabolites, Antineoplastic / therapeutic use. Basic Helix-Loop-Helix Leucine Zipper Transcription Factors. Biomarkers, Tumor / analysis. Cytoplasmic Vesicles / ultrastructure. Female. Humans. Microscopy, Electron, Transmission. Treatment Outcome

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  • (PMID = 15735860.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA88843
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Antimetabolites, Antineoplastic; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human; 0 / DNA-Binding Proteins; 0 / TFE3 protein, human; 0 / Transcription Factors; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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9. Tytherleigh MG, Birtle AJ, Cohen CE, Glynne-Jones R, Livingstone J, Gilbert J: Combined surgery and chemoradiation as a treatment for the Buschke-Löwenstein tumour. Surgeon; 2006 Dec;4(6):378-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combined surgery and chemoradiation as a treatment for the Buschke-Löwenstein tumour.
  • BACKGROUND: The Buschke-Löwenstein tumour (BLT) or giant condyloma acuminata is a rare disease which affects the anogenital region.
  • Although histologically benign, it behaves in a malignant fashion, infiltrating the surrounding tissues.
  • The morbidity and mortality from this tumour is high, as is the risk of recurrence following treatment.
  • It lies on the continuum between the benign condylomata acuminata and squamous cell carcinoma.
  • CONCLUSION: Pre-operative chemoradiation has proved to be useful in management for histologically proven benign BLT
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Condylomata Acuminata / therapy. Neoadjuvant Therapy. Perineum / pathology. Perineum / surgery. Soft Tissue Neoplasms / therapy
  • [MeSH-minor] Abdominal Neoplasms / secondary. Abdominal Neoplasms / therapy. Adult. Anus Neoplasms / secondary. Anus Neoplasms / therapy. Carcinoma in Situ / pathology. Carcinoma in Situ / therapy. Carcinoma, Squamous Cell / therapy. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Fatal Outcome. Fluorouracil / administration & dosage. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Radiotherapy, Adjuvant. Rectal Neoplasms / secondary. Rectal Neoplasms / therapy

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  • (PMID = 17152203.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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10. Sarikcioglu L, Demirel BM, Ozsoy U, Gurer EI, Oguz N, Ucar Y: Angiolipoma located inside the obturator canal and supplied by the umbilical artery. Ann Anat; 2007;189(1):75-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Microscopically the benign soft tissue tumor was characterized by lobules of mature adipocytes and densely distributed networks of small and larger blood vessels, thus resembling typical histological features of an angiolipoma.

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  • (PMID = 17319612.001).
  • [ISSN] 0940-9602
  • [Journal-full-title] Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft
  • [ISO-abbreviation] Ann. Anat.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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11. Bestic JM, Peterson JJ, Bancroft LW: Pediatric FDG PET/CT: Physiologic uptake, normal variants, and benign conditions [corrected]. Radiographics; 2009 Sep-Oct;29(5):1487-500
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pediatric FDG PET/CT: Physiologic uptake, normal variants, and benign conditions [corrected].
  • Standard imaging evaluation of bone and soft-tissue sarcomas typically consists of conventional radiography, magnetic resonance (MR) imaging, computed tomography (CT), and bone scintigraphy.
  • It represents a noninvasive means of estimating histologic tumor grade and can be used to detect progression or regression of disease prior to anatomic imaging.
  • [MeSH-major] Bone Neoplasms / radionuclide imaging. Bone Neoplasms / therapy. Fluorodeoxyglucose F18. Positron-Emission Tomography / methods. Sarcoma, Ewing / radionuclide imaging. Sarcoma, Ewing / therapy
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Neoplasm Staging. Prognosis. Radiopharmaceuticals. Treatment Outcome. Young Adult

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  • [Copyright] (c) RSNA, 2009.
  • [CommentIn] Radiographics. 2009 Sep-Oct;29(5):1500-1; discussion 1501 [19764110.001]
  • [ErratumIn] Radiographics. 2010 Jan-Feb;30(1):301
  • (PMID = 19755607.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 21
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12. Gengler C, Guillou L: Solitary fibrous tumour and haemangiopericytoma: evolution of a concept. Histopathology; 2006 Jan;48(1):63-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary fibrous tumour and haemangiopericytoma: evolution of a concept.
  • Haemangiopericytoma (HPC) was described in 1942 by Stout and Murray as a distinctive soft tissue neoplasm, presumably of pericytic origin, exhibiting a characteristic well-developed "staghorn" branching vascular pattern.
  • Over the years, it appeared that this growth pattern was a non-specific one, shared by numerous, unrelated benign and malignant lesions, and that HPC was better considered as a diagnosis of exclusion.
  • Three categories of lesion may now be individualized within the heterogeneous group of HPC-like neoplasms.
  • The first category corresponds to those non-HPC neoplasms that occasionally display HPC-like features (e.g. synovial sarcoma).
  • They generally show a benign clinical course, and include glomangiopericytoma/myopericytoma, infantile myofibromatosis (previously called infantile HPC), and a subset of sinonasal HPCs.
  • The third category is the solitary fibrous tumour (SFT) lesional group, which includes fibrous-to-cellular SFTs, and related lesions such as giant cell angiofibromas and lipomatous HPCs.
  • [MeSH-major] Fibroma / diagnosis. Hemangiopericytoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • (PMID = 16359538.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 70
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13. Miller DV, Wang H, Wang H, Fealey ME, Tazelaar HD: Beta-catenin mutations do not contribute to cardiac fibroma pathogenesis. Pediatr Dev Pathol; 2008 Jul-Aug;11(4):291-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cardiac fibromas are the 2nd most common benign cardiac tumor occurring in children and bear a striking morphologic resemblance to soft tissue or desmoid fibromatosis.
  • Since activating mutations in beta-catenin are common in desmoid fibromatosis as well as other spindle cell proliferations, the aim of our study was to determine if such mutations could be identified in cardiac fibroma.
  • We conclude that despite their morphologic similarity, cardiac fibroma and desmoid fibromatosis do not share this common molecular pathway of neoplastic growth.
  • [MeSH-major] Fibroma / genetics. Genetic Predisposition to Disease. Heart Neoplasms / genetics. beta Catenin / genetics
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Child. Child, Preschool. DNA Mutational Analysis. DNA, Neoplasm / analysis. Female. Humans. Immunoenzyme Techniques. Infant. Male. Mutation

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  • (PMID = 18078366.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / beta Catenin
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14. Tzanakis NE, Giannopoulos GA, Efstathiou SP, Rallis GE, Nikiteas NI: Angiomyofibroblastoma of the spermatic cord: a case report. J Med Case Rep; 2010;4:79
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Angiomyofibroblastoma is a benign soft tissue tumor with tendency to arise in the vulva.
  • At operation, a 4.5 cm well-circumscribed solid tumor was found adherent to the spermatic cord.
  • The tumor consisted of spindle-shaped cells proliferating in short fascicles between numerous medium-sized blood vessels with thin and hyalinized walls.
  • CONCLUSION: This unusual neoplasm should be distinguished from aggressive angiomyxoma and other myxoid malignant tumors with widespread metastatic potential.

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  • (PMID = 20202207.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2838917
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15. González-Bugatto F, Añón-Requena MJ, López-Guerrero MA, Báez-Perea JM, Bartha JL, Hervías-Vivancos B: Vulvar leiomyosarcoma in Bartholin's gland area: a case report and literature review. Arch Gynecol Obstet; 2009 Feb;279(2):171-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Malignant tumours of the vulvar soft tissue are very uncommon.
  • When localized in the Bartholin's gland area these tumours can be mistaken for benign lesions, leading to a delayed diagnosis.
  • [MeSH-major] Bartholin's Glands / pathology. Leiomyosarcoma / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Chemotherapy, Adjuvant. Diagnosis, Differential. Female. Groin. Humans. Lymph Node Excision. Middle Aged. Neoplasm Recurrence, Local / surgery. Radiotherapy, Adjuvant


16. Datir A, James SL, Ali K, Lee J, Ahmad M, Saifuddin A: MRI of soft-tissue masses: the relationship between lesion size, depth, and diagnosis. Clin Radiol; 2008 Apr;63(4):373-8; discussion 379-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MRI of soft-tissue masses: the relationship between lesion size, depth, and diagnosis.
  • AIMS: To identify the relationship between depth and size of soft-tissue mass lesions relative to histological diagnosis in a range of malignant neoplastic, benign neoplastic, and non-neoplastic conditions on magnetic resonance imaging (MRI).
  • METHOD: The MRI findings of 571 consecutive patients referred to a supra-regional orthopaedic oncology unit with a suspected soft-tissue neoplasm were reviewed and included in the study.
  • The patient age, histological diagnosis, lesion size, anatomical location, and lesion depth (superficial or deep to fascia) were recorded.
  • The mean age was 54.1 years for malignant neoplastic lesions compared with 40.1 years for benign neoplastic and 45.4 years for non-neoplastic conditions.
  • There was a significant age difference when malignant lesions were compared with benign neoplastic and non-neoplastic lesions (p<0.001).
  • No significant relationship was present between lesion depth (480 deep, 91 superficial) and diagnosis (288 malignant neoplastic, 197 benign neoplastic and 86 non-neoplastic lesions).
  • However, a significant relationship was identified between lesion size and diagnosis (p<0.001).
  • Furthermore, a significant relationship was identified when lesion size greater than 5 cm, lesion depth, and diagnosis were analysed.
  • CONCLUSION: Current guidelines suggest the most important variables for assessing risk of malignancy in a soft-tissue lesion include size, depth in relation to the fascia, increasing size, and pain.
  • [MeSH-major] Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Abscess / diagnosis. Abscess / pathology. Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Fibroma / diagnosis. Fibroma / pathology. Ganglion Cysts / diagnosis. Ganglion Cysts / pathology. Hemangioma / diagnosis. Hemangioma / pathology. Histiocytoma, Malignant Fibrous / diagnosis. Histiocytoma, Malignant Fibrous / pathology. Humans. Lipoma / diagnosis. Lipoma / pathology. Liposarcoma / diagnosis. Liposarcoma / pathology. Magnetic Resonance Imaging. Male. Middle Aged. Myositis Ossificans / diagnosis. Myositis Ossificans / pathology. Prospective Studies. Risk Factors. Sarcoma, Synovial / diagnosis. Sarcoma, Synovial / pathology

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  • (PMID = 18325355.001).
  • [ISSN] 0009-9260
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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17. Diniz MB, Giro Elisa MA, Zuanon Angela CC, Costa CA, Hebling J: Congenital epulis: a rare benign tumor in the newborn. J Indian Soc Pedod Prev Dent; 2010 Jul-Sep;28(3):230-3
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  • [Title] Congenital epulis: a rare benign tumor in the newborn.
  • Congenital epulis (CE) of the newborn is a rare benign soft tissue tumor that presents at birth.
  • A decisive diagnosis is made by histopathologic analysis as other newborn lesions can be incorrectly diagnosed as CE.
  • [MeSH-major] Gingival Neoplasms / congenital. Gingival Neoplasms / pathology

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  • (PMID = 21157060.001).
  • [ISSN] 0970-4388
  • [Journal-full-title] Journal of the Indian Society of Pedodontics and Preventive Dentistry
  • [ISO-abbreviation] J Indian Soc Pedod Prev Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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18. Edwards PC, Fantasia JE, Saini T, Rosenberg TJ, Sachs SA, Ruggiero S: Clinically aggressive central giant cell granulomas in two patients with neurofibromatosis 1. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Dec;102(6):765-72
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  • BACKGROUND: Neurofibromatosis 1 (NF1) is an autosomal dominantly inherited disorder caused by a spectrum of mutations affecting the Nf1 gene.
  • Affected patients develop benign and malignant tumors at an increased frequency.
  • Clinical findings include multiple cutaneous café-au-lait pigmentations, neurofibromas, axillary freckling, optic gliomas, benign iris hamartomas (Lisch nodules), scoliosis, and poorly defined soft tissue lesions of the skeleton.
  • Alternatively, the CGCG in NF1 patients could represent a true neoplasm, resulting from additional, as of yet unidentified, genetic alterations to Nf1-haploinsufficient bone.


19. Nazir SA, Raza SA, Nazir S, Sherwood W, Bowker C, Lakhoo K: Challenges in the prenatal and post-natal diagnosis of mediastinal cystic hygroma: a case report. J Med Case Rep; 2008;2:256
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  • [Title] Challenges in the prenatal and post-natal diagnosis of mediastinal cystic hygroma: a case report.
  • INTRODUCTION: Cystic hygroma is a benign congenital neoplasm that mostly presents as a soft-tissue mass in the posterior triangle of the neck.
  • The diagnosis is often made intra- or postoperatively.
  • Prenatal identification is exceptional and post-natal diagnosis also proves challenging.
  • CASE PRESENTATION: We report one such case that was mistaken for other entities in both the prenatal and immediate post-natal period.
  • After excision, histopathological examination of the mass confirmed the diagnosis of cystic hygroma.
  • CONCLUSION: Despite the fact that isolated intrathoracic cystic hygroma is a rare entity, it needs to be considered in the differential diagnosis of foetal and neonatal mediastinal masses, particularly for juxtadiaphragmatic lesions.
  • Post-natal diagnosis may also be misleading as many mediastinal cystic masses have similar appearances on imaging.

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  • [Cites] Am Heart J. 1995 Feb;129(2):406-9 [7832119.001]
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  • (PMID = 18673546.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2518156
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20. Matthews A, Tang M, Cooper K: Cytogenetic aberrations in soft tissue tumors harvested from fresh tissue submitted for surgical pathology: a single institutional experience. Int J Surg Pathol; 2010 Aug;18(4):260-7
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  • [Title] Cytogenetic aberrations in soft tissue tumors harvested from fresh tissue submitted for surgical pathology: a single institutional experience.
  • AIMS: Recurrent cytogenetic abnormalities have been reported in many types of soft tissue neoplasms, and the detection of these aberrations imparts diagnostic utility.
  • The aim of this study is to demonstrate that classical karyotyping may be performed with minimal effort as an adjunct to surgical pathology on fresh tissue submitted for histopathological examination.
  • To the authors' knowledge, there are no recently published reviews in the literature in English of cytogenetic abnormalities in soft tissue tumors from a single institution.
  • METHODS: Conventional metaphase cytogenetics was performed in the authors' cytogenetics laboratory on fresh tissue from mesenchymal tumors from their surgical pathology laboratory over a period of 4 years.
  • Cytogenetics reports, clinical history, and histopathology were reviewed for 48 soft tissue tumors.
  • Recurrent cytogenetic abnormalities were identified using the Mitelman Database of Chromosome Aberrations in Cancer and a review of the literature.
  • RESULTS: The authors reviewed 48 cases of benign and malignant soft tissue tumors, which included 28 distinct morphologies.
  • CONCLUSIONS: Cytogenetic analysis demonstrated abnormal karyotypes in nearly half of this series of mesenchymal neoplasms, the majority of which consisted of recognized aberrations reported in the literature.
  • [MeSH-major] Chromosome Aberrations. Pathology, Surgical / methods. Sarcoma / genetics. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Infant. Karyotyping. Male. Middle Aged. Neoplasm Recurrence, Local. Young Adult

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  • (PMID = 19776087.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Tetikkurt C, Tetikkurt S, Bayar N: Diagnosis of elastofibroma. Can Respir J; 2008 May-Jun;15(4):217-8
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  • [Title] Diagnosis of elastofibroma.
  • Elastofibroma is a relatively rare soft tissue mass.
  • It is a degenerative benign neoplasm with the clinical appearence of a malignant tumour.
  • The diagnosis was established with needle aspiration biopsy and positron emission tomography/computed tomography.
  • The present case suggests that needle aspiration biopsy and positron emission tomography/computed tomography are highly useful in the diagnosis of this rare, benign tumour.
  • [MeSH-major] Fibroma / diagnosis. Shoulder. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 18551204.001).
  • [ISSN] 1198-2241
  • [Journal-full-title] Canadian respiratory journal
  • [ISO-abbreviation] Can. Respir. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2677955
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22. Folpe AL, Mentzel T, Lehr HA, Fisher C, Balzer BL, Weiss SW: Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature. Am J Surg Pathol; 2005 Dec;29(12):1558-75
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  • [Title] Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature.
  • This family of tumors includes angiomyolipoma (AML), clear cell sugar tumor of the lung (CCST), lymphangioleiomyomatosis (LAM), and very rare tumors in other locations.
  • Because non-AML/non-LAM PEComas are extremely rare and their natural history and prognostic features undefined, we present our experience with 26 PEComas of soft tissue and the gynecologic tract, the largest series to date.
  • Sites of involvement included the omentum or mesentery (6 cases), uterus (4 cases), pelvic soft tissues (3 cases), abdominal wall (2 cases), uterine cervix (2 cases), and vagina, retroperitoneum, thigh, falciform ligament, scalp, broad ligament, forearm, shoulder, and neck (1 case each).
  • Recurrence and/or metastasis was strongly associated tumor size > median size (8 cm), mitotic activity greater than 1/50 HPF, and necrosis.
  • We conclude that PEComas of soft tissue and gynecologic origin may be classified as "benign," "of uncertain malignant potential," or "malignant."
  • Small PEComas without any worrisome histologic features are most likely benign.
  • PEComas with nuclear pleomorphism alone ("symplastic") and large PEComas without other worrisome features have uncertain malignant potential.
  • [MeSH-major] Biomarkers, Tumor / analysis. Epithelioid Cells / pathology. Genital Neoplasms, Female / pathology. Neoplasms, Connective and Soft Tissue / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Follow-Up Studies. Humans. Immunohistochemistry. Immunophenotyping. Male. Middle Aged. Mitosis. Neoplasm Metastasis. Neoplasm Recurrence, Local. Retrospective Studies. Survival Analysis. Time Factors. Treatment Outcome. Tumor Burden

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  • (PMID = 16327428.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 56
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23. Nilsson M, Domanski H, Mertens F, Mandahl N: Atypical lipomatous tumor with rare structural rearrangements involving chromosomes 8 and 12. Oncol Rep; 2005 Apr;13(4):649-52
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  • [Title] Atypical lipomatous tumor with rare structural rearrangements involving chromosomes 8 and 12.
  • Atypical lipomatous tumor (ALT), an intermediate malignant neoplasm of soft tissues, is characterized by the presence of supernumerary ring and giant marker chromosomes.
  • These supernumerary chromosomes consistently contain amplified 12q-material in association with amplified segments from a variety of other chromosomes.
  • However, a few cases of ALT with other types of chromosomal rearrangements have been reported earlier.
  • These findings are consistent with previous reports that the ALT phenotype may be associated with a low or moderate level of gene amplification, whereas truncation of HMGA2 has been observed in both ALTs and benign lipomas.
  • Whether ALTs with these types of aberrations have a lower risk of tumor progression than ALTs with the notoriously mitotically unstable ring and giant marker chromosomes remains to be investigated.
  • [MeSH-major] Chromosome Aberrations. Chromosomes, Human, Pair 12. Chromosomes, Human, Pair 8. Lipoma / genetics. Lipoma / pathology. Neoplasms, Adipose Tissue / genetics. Neoplasms, Adipose Tissue / pathology

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  • (PMID = 15756437.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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24. Khalid K, Alam MK, Al-Shakweer WA, Al-Teimi IN: Granular cell tumour of the ampulla of Vater. J Postgrad Med; 2005 Jan-Mar;51(1):36-8
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  • [Title] Granular cell tumour of the ampulla of Vater.
  • Granular cell tumour (GCT) is a rare soft tissue neoplasm commonly encountered in the head and neck region, skin and subcutaneous tissue.
  • The neoplasm constitutes less than 10% of all benign tumours of the extra-hepatic biliary tree.
  • We report a case of benign GCT involving the ampullary region in a 44-year-old Ethiopian male.
  • Preoperative diagnosis was available on ERCP and deep biopsy.
  • The patient was managed by debulking resection and biliary-enteric bypass and is symptom-free with no evidence of tumour progression after a follow-up of one year.
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / diagnosis. Granular Cell Tumor / diagnosis

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  • (PMID = 15793336.001).
  • [ISSN] 0022-3859
  • [Journal-full-title] Journal of postgraduate medicine
  • [ISO-abbreviation] J Postgrad Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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25. Unlu HH, Songu M, Ovali GY, Nese N: Inverted papilloma with new bone formation: report of three cases. Am J Rhinol; 2007 Sep-Oct;21(5):607-10
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  • BACKGROUND: An inverted papilloma (IP) is a benign sinonasal tumor of ectodermal origin, which is locally aggressive and destructive, tends to recur if incompletely removed, and has significant malignant potential.
  • On CT scan, the appearance of an IP is variable and nonspecific but most commonly it appears to have soft tissue density.
  • METHODS: We report three cases with existence of bony mass surrounded by polypoid soft tissue diagnosed as IP histopathologically.
  • We also believe that additional investigations are required to characterize the pathophysiological mechanisms involved in neoplasm-induced osteogenesis.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Papilloma, Inverted / pathology. Paranasal Sinus Neoplasms / pathology

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  • (PMID = 17999798.001).
  • [ISSN] 1050-6586
  • [Journal-full-title] American journal of rhinology
  • [ISO-abbreviation] Am J Rhinol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Ech-Cherif El Kettani N, Nassar I, Bouklata S, Hammani L, Kabbaj N, Gueddari FZ, Lola N, Ajana A, Imani F: [Glomus tumor of the leg: a case report]. J Radiol; 2005 May;86(5 Pt 1):493-5
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  • [Title] [Glomus tumor of the leg: a case report].
  • [Transliterated title] A propos d'une tumeur glomique de la jambe.
  • Glomus tumor is an uncommon benign neuromyoarterial tumor.
  • It most frequently involves the fingers, and only rarely involves other sites.
  • [MeSH-major] Glomus Tumor / radiography. Leg / radiography. Soft Tissue Neoplasms / radiography
  • [MeSH-minor] Aged. Humans. Male. Neoplasm Recurrence, Local / radiography. Tomography, X-Ray Computed

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  • (PMID = 16114206.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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27. Rubin AI, Yassaee M, Johnson W, Elenitsas R, Zaladonis J Jr, Seykora JT: Multiple cutaneous sclerosing perineuriomas: an extensive presentation with involvement of the bilateral upper extremities. J Cutan Pathol; 2009 Oct;36 Suppl 1:60-5
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  • A perineurioma is a benign peripheral nerve sheath neoplasm thought to be derived from cells of the perineurium, the cellular sheathing of peripheral nerve fascicles.
  • The histological, immunohistochemical (positive for epithelial membrane antigen, collagen type IV, laminin and vimentin but not S-100 protein) and ultrastructural features of a perineurioma form the basis for diagnosis.
  • Two types of perineuriomas are recognized, intraneural and soft tissue (extraneural) forms.
  • Sclerosing perineurioma is considered a variant of the soft tissue perineurioma.
  • [MeSH-major] Neoplasms, Multiple Primary / pathology. Nerve Sheath Neoplasms / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19187114.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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28. Klijanienko J, Caillaud JM, Lagacé R: Cytohistologic correlations in schwannomas (neurilemmomas), including "ancient," cellular, and epithelioid variants. Diagn Cytopathol; 2006 Aug;34(8):517-22
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  • Schwannoma accounts for one of the most common benign mesenchymal neoplasms of soft tissues.
  • Original cytologic diagnosis was schwannoma in 13 (38.2%) cases, benign soft tissue tumor in 11 (32.4%), pleomorphic adenoma in 2 (6%) cases, angioma in 1 (2.9%) case, nodular fasciitis in 1 (2.9%) case, suspicious in 3 (8.8%) cases, and not satisfactory in 3 (8.8%) cases.
  • Similarly, cyto-nuclear atypia was more frequent in classical subtype than in other subtypes.
  • Schwannoma should be differentiated from well-differentiated malignant peripheral nerve sheath tumor, neurofibroma, and pleomorphic adenoma, in the last instance particularly for head and neck lesions.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Neurilemmoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Reproducibility of Results

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16850489.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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29. Kurugoglu S, Adaletli I, Mihmanli I, Kanberoglu K: Lumbosacral osseous tumors in children. Eur J Radiol; 2008 Feb;65(2):257-69
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  • A wide variety of benign and malignant neoplasms in children involve the lumbosacral region.
  • When a solitary lesion of the lower spine occurs, tumors or tumor-like lesions represent an important group of entities for diagnostic consideration.
  • MRI shows soft-tissue masses and medullary infiltration better than any other radiological modality.
  • A multimodal radiological approach is helpful in the overall evaluation and differential diagnosis of vertebral lesions in children.
  • Although imaging features, especially of benign lesions, may yield a high percentage of accurate diagnoses, in cases with radiological findings highly suggestive of malignancy, a specific diagnosis cannot always be made, and histopathological findings are essential to achieve the diagnosis that will guide the therapy.
  • [MeSH-major] Lumbosacral Region. Spinal Neoplasms / diagnosis
  • [MeSH-minor] Child. Contrast Media. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Neoplasm Metastasis / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 17498904.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 46
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30. Aytac-Yazicioglu D, Eren H, Görgün S: Peripheral odontogenic myxoma located on the maxillary gingiva: report of a case and review of the literature. Oral Maxillofac Surg; 2008 Sep;12(3):167-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Odontogenic myxoma is a rare, benign neoplasm and is often located in the maxillofacial region centrally most common in the mandible.
  • Soft tissue localization that can be classified as a peripheral myxoma is rarely seen than the central localization.
  • [MeSH-major] Gingival Neoplasms / pathology. Myxoma / pathology. Odontogenic Tumors / pathology

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  • [Cites] Diagn Cytopathol. 2002 Aug;27(2):111-4 [12203879.001]
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  • (PMID = 18642035.001).
  • [ISSN] 1865-1550
  • [Journal-full-title] Oral and maxillofacial surgery
  • [ISO-abbreviation] Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 39
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31. Thway K, Fisher C, Debiec-Rychter M, Calonje E: Claudin-1 is expressed in perineurioma-like low-grade fibromyxoid sarcoma. Hum Pathol; 2009 Nov;40(11):1586-90
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  • Low-grade fibromyxoid sarcoma is a soft tissue sarcoma with recurrent and low metastatic potential, which has characteristic FUS-CREB3L2 or FUS-CREB3L1 fusions.
  • Perineurioma is a peripheral nerve sheath neoplasm, which is usually benign.
  • This has implications toward the accurate diagnosis of both tumors, and, as positivity for claudin-1 in low-grade fibromyxoid sarcoma is not previously documented, suggests that there might be underdiagnosis of low-grade fibromyxoid sarcoma.
  • [MeSH-major] Biomarkers, Tumor / analysis. Fibrosarcoma / pathology. Membrane Proteins / biosynthesis. Nerve Sheath Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Claudin-1. Diagnosis, Differential. Female. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Male. Middle Aged. Mucin-1 / biosynthesis. Young Adult

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  • (PMID = 19540561.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CLDN1 protein, human; 0 / Claudin-1; 0 / Membrane Proteins; 0 / Mucin-1
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32. Pellegrino M, Vadrucci S, Tinelli A: [Angiomyofibroblastoma of the vulva: a rare but distinct entity. Case report and literature review]. Pathologica; 2007 Dec;99(6):438-9
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  • Angiomyofibroblastoma is a benign vulvar tumour involving soft tissue that is characterized by alternating hypocellular and hypercellular areas of spindle stromal cells, admixed and aggregated around blood vessels.
  • It is important to recognize this entity as it shows benign behaviour with respect to other mesenchymal tumours of the vagina, which have a more aggressive behaviour.
  • [MeSH-major] Angiofibroma / pathology. Angiomyoma / pathology. Hemangioblastoma / pathology. Neoplasms, Second Primary / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, CD34 / analysis. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor. Breast Neoplasms / drug therapy. Breast Neoplasms / surgery. Combined Modality Therapy. Female. Humans. Lymphoma, Large B-Cell, Diffuse / drug therapy. Lymphoma, Large B-Cell, Diffuse / surgery. Neoplasm Proteins / analysis. Receptors, Estrogen / analysis

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  • (PMID = 18416337.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Receptors, Estrogen
  • [Number-of-references] 7
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33. Weber K, Damron TA, Frassica FJ, Sim FH: Malignant bone tumors. Instr Course Lect; 2008;57:673-88
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  • Malignant bone tumors represent a small percentage of cancers nationwide and also are much less common than malignant soft-tissue tumors.
  • The primary symptom of a patient with a malignant bone tumor is pain, which often occurs at rest or at night.
  • Patients with a likely malignancy require thorough staging to determine the extent of disease and a well-planned biopsy for accurate diagnosis.
  • Knowledge of specific tumor characteristics and treatment options for osteosarcoma, Ewing's sarcoma, chondrosarcoma, malignant fibrous histiocytoma, chordoma, and adamantinoma is important.
  • Secondary sarcomas can occur in previously benign bone lesions and require aggressive treatment.
  • [MeSH-major] Bone Neoplasms. Orthopedic Procedures / methods
  • [MeSH-minor] Global Health. Humans. Morbidity. Neoplasm Staging / methods. Prognosis

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  • (PMID = 18399615.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 42
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34. Dong MJ, Zhou GY: [Imaging diagnosis of hemangioma in infants]. Shanghai Kou Qiang Yi Xue; 2008 Apr;17(2):221-4
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  • [Title] [Imaging diagnosis of hemangioma in infants].
  • Hemangioma is the most commonly benign tumor of soft tissue tumors in infants.
  • In this article, the current situation of application with all imaging examinations used in diagnosis of hemangioma is reviewed.
  • [MeSH-major] Hemangioma / diagnosis

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  • (PMID = 18470434.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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35. Wilde F, Neid M, Schulz T, Sterker I, Hemprich A, Frerich B: [Hemangiopericytoma (extrapleural solitary fibrous tumour). Exemplified and discussed on the basis of two cases]. Mund Kiefer Gesichtschir; 2005 Nov;9(6):404-8
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  • [Title] [Hemangiopericytoma (extrapleural solitary fibrous tumour). Exemplified and discussed on the basis of two cases].
  • [Transliterated title] Hämangioperizytom (extrapleuraler solitärer fibröser Tumor). Dargestellt und diskutiert anhand zweier Patientenbeispiele.
  • It is a very uncommon potentially malignant vascular tumour which can occur at every site of the body.
  • The diagnosis of "hemangiopericytoma" is now only determined if a constant histological picture of hemangiopericytoma is present.
  • The tumour can lead to lymphogenous or hematogenous metastasis.
  • CASE REPORTS: Patient 1: 60 years, female; diagnosis: malignant suboccipital hemangiopericytoma; size: 4.9 x 4.5 x 4.2 cm; pT1bNXMX L0 V0 Pn0; stage IA; grading G1; R0.Patient 2: 38 years, male; diagnosis: benign hemangiopericytoma infraorbital left; size 1.5 x 1.5 x 1.5 cm.
  • The consistency ranges from soft to dense, and the color is greyish-blue.
  • The slow and painless growth carries the danger of a clinically wrong diagnosis and thus delayed therapy.
  • The histological diagnosis of hemangiopericytoma is determined by biopsy.
  • The therapy of choice is the complete tumour-resection with a safety margin of 1 cm.
  • [MeSH-major] Eyelid Neoplasms / diagnosis. Head and Neck Neoplasms / diagnosis. Hemangiopericytoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery. Orbit / pathology. Orbital Neoplasms / diagnosis. Orbital Neoplasms / pathology. Orbital Neoplasms / surgery. Reoperation. Tomography, X-Ray Computed

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  • (PMID = 16220316.001).
  • [ISSN] 1432-9417
  • [Journal-full-title] Mund-, Kiefer- und Gesichtschirurgie : MKG
  • [ISO-abbreviation] Mund Kiefer Gesichtschir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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36. Plaza JA, Wakely PE Jr, Suster S: Lipoblastic nerve sheath tumors: report of a distinctive variant of neural soft tissue neoplasm with adipocytic differentiation. Am J Surg Pathol; 2006 Mar;30(3):337-44
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  • [Title] Lipoblastic nerve sheath tumors: report of a distinctive variant of neural soft tissue neoplasm with adipocytic differentiation.
  • Benign nerve sheath tumors of soft tissue can occasionally adopt unusual or unfamiliar morphologic appearances that may introduce difficulties for diagnosis, such as multinucleation, bizarre nuclei, intranuclear vacuoles, and other degenerative changes.
  • Tumor cells adopting a signet-ring or lipoblast-like configuration, however, are mostly associated with epithelial malignancies, liposarcoma and melanoma, and have been only rarely observed in spindle cell tumors of soft tissue.
  • We report 5 cases of benign nerve sheath neoplasms that displayed prominent signet-ring cells with lipoblast-like features.
  • The cases presented as solitary soft tissue masses in the groin, thigh, retroperitoneum, and shoulder in 4 men and 1 woman between the ages of 31 to 57 years.
  • The signet-ring cells were negative for mucin stains, cytokeratin, EMA, CEA, and several other differentiation markers.
  • The presence of mature fat and signet-ring lipoblast-like cells within a nerve sheath neoplasm is quite rare and may signify a process of aberrant differentiation.
  • Neurogenic tumors should be added in the differential diagnosis of spindle cell tumors capable of displaying prominent signet-ring cell features.
  • [MeSH-major] Adipose Tissue / pathology. Nerve Sheath Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Carcinoma, Signet Ring Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission. Middle Aged

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  • (PMID = 16538053.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Clayer M: Open incisional biopsy is a safe and accurate technique for soft tissue tumours. ANZ J Surg; 2010 Nov;80(11):786-8
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  • [Title] Open incisional biopsy is a safe and accurate technique for soft tissue tumours.
  • BACKGROUND: Accurate diagnosis of musculoskeletal tumours is important for successful treatment.
  • METHODS: This study was a retrospective audit of 135 consecutive open incisional biopsies of soft tissue tumours.
  • There were three cases where the biopsy incorrectly reported a benign condition when it was malignant (benign versus malignant accuracy 96%).
  • There were no cases of benign initially being reported as malignant.
  • The tissue diagnosis was correct in 72 of the excised specimens (accuracy 82%).
  • The false positive rate for malignant versus benign was 0%, sensitivity 93%, specificity 100% and positive predictor value 100%.
  • DISCUSSION: Open incisional biopsy remains a safe and accurate method of obtaining a tissue diagnosis when the principles of biopsy are adhered to.
  • [MeSH-major] Biopsy / methods. Neoplasm Recurrence, Local / pathology. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Cohort Studies. False Negative Reactions. False Positive Reactions. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Safety Management. Sensitivity and Specificity. Survival Analysis

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  • [Copyright] © 2010 The Author. ANZ Journal of Surgery © 2010 Royal Australasian College of Surgeons.
  • (PMID = 20969684.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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38. Manor E, Sion-Vardy N, Nash M, Bodner L: Angiomyoma of buccal vestibule: a rare case with a normal karyotype. J Laryngol Otol; 2007 Dec;121(12):1210-2
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  • Angiomyoma is an uncommon, benign, soft tissue tumour characterised by bundles of smooth muscle cells intermixed with numerous vascular channels, which usually develops in the lower extremities.
  • [MeSH-major] Angiomyoma / diagnosis. Mouth Neoplasms / diagnosis
  • [MeSH-minor] Adult. Cheek. Diagnosis, Differential. Humans. Male

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  • (PMID = 17524173.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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39. Garner HW, Kransdorf MJ, Bancroft LW, Peterson JJ, Berquist TH, Murphey MD: Benign and malignant soft-tissue tumors: posttreatment MR imaging. Radiographics; 2009 Jan-Feb;29(1):119-34
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  • [Title] Benign and malignant soft-tissue tumors: posttreatment MR imaging.
  • Soft-tissue sarcoma requires aggressive treatment, often with a combination of radiation therapy, chemotherapy, and surgical resection.
  • The challenge of distinguishing posttreatment change from recurrent tumor may be minimized by using an organized, systematic approach to imaging, with emphasis on the patient's clinical and surgical history and a review of pretreatment images.
  • Common changes that result from radiation therapy include soft-tissue trabeculation, increased fatty marrow, and focal marrow abnormalities.
  • Occasionally, it causes a substantial increase in tumor size that is a result of chemotherapy-induced hemorrhage.
  • Recurrent tumor is characterized by the presence of a discrete nodule or mass with signal characteristics that typically mirror those of the original tumor.
  • MR imaging sequences such as unenhanced T1-weighted fat-suppressed and gradient-echo sequences may help differentiate posttreatment hemorrhage from local tumor recurrence.
  • [MeSH-major] Image Enhancement / methods. Magnetic Resonance Imaging / methods. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / prevention & control. Sarcoma / diagnosis. Sarcoma / therapy

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  • [Copyright] (c) RSNA, 2009.
  • (PMID = 19168840.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Klenke FM, Merkle T, Fellenberg J, Abdollahi A, Huber PE, Gebhard MM, Ewerbeck V, Sckell A: A novel model for the investigation of orthotopically growing primary and secondary bone tumours using intravital microscopy. Lab Anim; 2005 Oct;39(4):377-83
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  • Although up to 85% of the most frequently occurring malignant solid tumours, such as lung and prostate carcinomas, metastasize into the bone, and despite the knowledge that a tumour's course may be altered by its surrounding tissue, there is no adequate experimental model available enabling the investigation of orthotopically grown bone tumours in vivo.
  • Intravital microscopy is an internationally accepted experimental method, used in various acute and chronic animal models, that enables qualitative and quantitative analysis of the angiogenesis, microcirculation, growth behaviour, etc. of various benign and malignant tissues.
  • Additionally, tissue samples can be taken after termination of the in vivo experiments for further ex vivo investigation (histology, immunohistochemistry, molecular biology, etc.
  • Severe combined immunodeficient mice were fitted with a cranial window preparation where the calvaria served as the site for orthotopic implantation of the solid human tumours Saos-2 osteosarcoma (primary) and A 549 lung carcinoma and PC-3 prostate carcinoma (secondary).
  • Histological assessment confirmed the data obtained in vivo, showing typical tumour growth with infiltration of the surrounding osseous and soft tissues.
  • This novel model serves as a valuable tool in understanding the biology of primary and secondary bone tumours in physiological and pathophysiological situations, with implications for the most areas of tumour therapy such as chemotherapy, radiation and antiangiogenesis.
  • [MeSH-major] Bone Neoplasms / pathology. Osteosarcoma / pathology
  • [MeSH-minor] Animals. Lung Neoplasms / pathology. Male. Mice. Mice, SCID. Microscopy, Fluorescence. Microscopy, Video. Neoplasm Transplantation. Neovascularization, Pathologic / pathology. Prostatic Neoplasms / pathology

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  • (PMID = 16197704.001).
  • [ISSN] 0023-6772
  • [Journal-full-title] Laboratory animals
  • [ISO-abbreviation] Lab. Anim.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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41. Sherwani RK, Kumar A: Solitary fibrous tumour of the lower leg: an uncommon site with atypical histopathological features. BMJ Case Rep; 2010;2010
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  • [Title] Solitary fibrous tumour of the lower leg: an uncommon site with atypical histopathological features.
  • On local examination, the overlying skin was normal and the mass was soft to firm in consistency, non-tender and freely mobile with no fixity to underlying structures.
  • MRI revealed a lobulated mass with central areas of necrosis and no involvement of underlying muscles and neurovascular bundles suggesting a benign soft tissue tumour.
  • The tumour was totally excised and submitted for histopathological examination, which, along with immunopositivity for CD34, CD99 and focally for Bcl2, led to a confirmatory diagnosis of solitary fibrous tumour with atypical histopathological features of increased mitosis and necrosis.
  • [MeSH-major] Leg / pathology. Soft Tissue Neoplasms / pathology. Solitary Fibrous Tumors / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Male

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  • [Cites] Cancer. 2002 Feb 15;94(4):1057-68 [11920476.001]
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  • (PMID = 22791854.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC3027392
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42. Chiou HJ, Chou YH, Chiu SY, Wang HK, Chen WM, Chen TH, Chang CY: Differentiation of benign and malignant superficial soft-tissue masses using grayscale and color doppler ultrasonography. J Chin Med Assoc; 2009 Jun;72(6):307-15
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  • [Title] Differentiation of benign and malignant superficial soft-tissue masses using grayscale and color doppler ultrasonography.
  • BACKGROUND: This study was performed to evaluate the usefulness of high-resolution grayscale and color Doppler ultrasound to distinguish benign from malignant soft-tissue masses on the basis of ultrasonographic patterns.
  • Each lesion was examined by grayscale and color Doppler ultrasonography to assess its echogenicity, margin, shape, composition, acoustic transmission, size and other patterns.
  • RESULTS: There were a total of 693 benign and 125 malignant masses.
  • Five malignant and 14 benign histologies (including 6 types with inflammation-related, hematoma or pseudoaneurysm) occurred that had more than 10 subjects with each histology.
  • Eight benign histopathologies included cysts, neoplasms, vascular and miscellaneous.
  • There were significant differences (p < 0.05) between the benign and malignant soft-tissue tumors in terms of parameters including tumor margin, shape and size.
  • Benign lesions did not have infiltrated margins or a scalloped shape and malignant tumors tended to be large.
  • However, there was no significant difference (p > 0.05) between the benign and malignant soft-tissue tumors in terms of echogenicity, composition and color Doppler features.
  • CONCLUSION: Ultrasonography with color Doppler imaging is a good modality for characterizing most soft-tissue masses, and tumor size > 5 cm and having infiltrated margin highly suggests malignancy.
  • [MeSH-major] Soft Tissue Neoplasms / ultrasonography. Ultrasonography, Doppler, Color / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Epidermal Cyst / pathology. Epidermal Cyst / ultrasonography. Female. Giant Cell Tumors / pathology. Giant Cell Tumors / ultrasonography. Hemangioma / pathology. Hemangioma / ultrasonography. Humans. Infant. Liposarcoma / pathology. Liposarcoma / ultrasonography. Male. Middle Aged. Neoplasm Metastasis. Neurilemmoma / pathology. Neurilemmoma / ultrasonography. Retrospective Studies

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  • (PMID = 19541566.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China (Republic : 1949- )
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43. Gopalan A, Sharp DS, Fine SW, Tickoo SK, Herr HW, Reuter VE, Olgac S: Urachal carcinoma: a clinicopathologic analysis of 24 cases with outcome correlation. Am J Surg Pathol; 2009 May;33(5):659-68
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  • RESULT: The mean age at diagnosis was 52 years (range: 26 to 68 y).
  • In all instances but 1, cystitis cystica/glandularis was focal and predominantly in the bladder overlying the urachal neoplasm.
  • Urachal remnants were identified in 15 cases: the urachal epithelium was benign urothelial-type in 6 cases and showed adenomatous changes in 9.
  • In all 3, urachal remnants were identified and showed transition from benign to adenomatous epithelium.
  • One patient had a positive soft tissue margin.
  • Surface urothelial involvement by carcinoma and presence of cystitis cystica/glandularis do not necessarily exclude the diagnosis of urachal carcinoma.
  • Immunostains do not unequivocally discriminate a urachal from a colorectal carcinoma, but diffuse positivity for 34BE12 would support, and diffuse nuclear immunoreactivity for beta-catenin would militate against, a diagnosis of urachal carcinoma.
  • [MeSH-major] Carcinoma / pathology. Urachus / pathology. Urinary Bladder Neoplasms / pathology. Urothelium / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Carcinoma, Signet Ring Cell / pathology. Chemotherapy, Adjuvant. Cystectomy. Cystitis / pathology. Databases as Topic. Female. Homeodomain Proteins / analysis. Humans. Immunohistochemistry. Keratin-20 / analysis. Keratin-7 / analysis. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local. Neoplasm Staging. Radiotherapy, Adjuvant. Treatment Outcome. Umbilicus / surgery. beta Catenin / analysis

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  • [Cites] Am J Surg Pathol. 2001 Nov;25(11):1380-7 [11684954.001]
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  • (PMID = 19252435.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / T32 CA082088
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDX2 protein, human; 0 / CTNNB1 protein, human; 0 / Homeodomain Proteins; 0 / KRT20 protein, human; 0 / KRT7 protein, human; 0 / Keratin-20; 0 / Keratin-7; 0 / beta Catenin
  • [Other-IDs] NLM/ NIHMS627175; NLM/ PMC4225778
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44. Puhaindran ME, Healey JH, Athanasian EA: Single ray amputation for tumors of the hand. Clin Orthop Relat Res; 2010 May;468(5):1390-5
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  • The role of this procedure in the management of aggressive benign or malignant hand tumors has been described only in case reports and small case series.
  • The other was treated with radiotherapy alone, as local tumor control would have required a hand amputation.
  • Functional assessment based on the Musculoskeletal Tumor Society staging system showed an average of 27.5 (range, 21-30).
  • However, function can be compromised by radiotherapy and a decrease in grip strength by a mean of 34% is to be expected.
  • [MeSH-major] Amputation / methods. Bone Neoplasms / surgery. Hand / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Time Factors. Treatment Outcome. Young Adult

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  • (PMID = 19655212.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2853661
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45. Cerdá-Nicolás M, Löpez-Gines C, Gil-Benso R, Benito R, Pellin A, Ruiz-Saurí A, Sanchos-Garcia J, Roldan P, Talamantes F, Barberá J: Solitary fibrous tumor of the orbit: morphological, cytogenetic and molecular features. Neuropathology; 2006 Dec;26(6):557-63
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  • [Title] Solitary fibrous tumor of the orbit: morphological, cytogenetic and molecular features.
  • Solitary fibrous tumor (SFT), a benign neoplasm arising in mesenchymal structures, was initially described in the pleura but subsequently has also been documented in other locations.
  • It is uncommon in the orbit, where it closely resembles other benign spindle-shaped mesenchymal tumors of this area such as schwannoma, meningioma or hemangiopericytoma.
  • Measurement of DNA content revealed a DNA index of 1, indicating a diploid peak in 95% of the tumor cells.
  • No p14(ARF), p15(INK4B) and p16(INK4A) deletions or hypermethylation were observed in this benign tumor.
  • Following surgical resection and radiotherapy, the patient showed no tumor relapse after one year of follow-up.
  • [MeSH-major] Fibroma / genetics. Fibroma / pathology. Orbital Neoplasms / genetics. Orbital Neoplasms / pathology
  • [MeSH-minor] Adult. Cyclin-Dependent Kinase Inhibitor p15 / genetics. Cyclin-Dependent Kinase Inhibitor p16 / genetics. DNA Methylation. Exons / genetics. Female. Gene Deletion. Genes, p53 / genetics. Humans. Magnetic Resonance Imaging. Point Mutation. Proto-Oncogene Proteins c-mdm2 / genetics. Soft Tissue Neoplasms / genetics. Soft Tissue Neoplasms / pathology. Tumor Suppressor Protein p14ARF / genetics

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  • (PMID = 17203593.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p15; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Tumor Suppressor Protein p14ARF; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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46. Takahara M, Ichikawa R, Oda Y, Uchi H, Takeuchi S, Moroi Y, Kiryu H, Furue M: Desmoplastic fibroblastoma: a case presenting as a protruding nodule in the dermis. J Cutan Pathol; 2008 Oct;35 Suppl 1:70-3
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  • Desmoplastic fibroblastoma is a rare, benign, soft tissue tumor.
  • Histological examination from total excision showed a well-circumscribed tumor in the dermis, which comprised of spindle, oval and stellate cells arranged in a haphazard fashion, accompanied by abundant collagenous stroma and inconspicuous vasculature.
  • Immunohistochemically, the tumor cells were positive for vimentin, and focally positive for alpha-smooth muscle actin and muscle-specific actin, but negative for CD34, S-100 protein, desmin and beta-catenin.
  • We diagnosed this case as desmoplastic fibroblastoma arising in the dermis and superficial subcutaneous tissue.
  • [MeSH-major] Fibroma / pathology. Soft Tissue Neoplasms / pathology

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  • [Copyright] Copyright Blackwell Munksgaard 2008.
  • (PMID = 18544056.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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47. Hatori M, Watanabe M, Kotake H, Kokubun S: Chondrosarcoma of the ring finger: a case report and review of the literature. Tohoku J Exp Med; 2006 Mar;208(3):275-81
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  • Enchondromas are the most common benign cartilaginous bone tumors arising in the medullary cavity of the small bones of the hand.
  • The findings of cortical irregular thickening by plain radiography and computed tomography and soft tissue extension by magnetic resonance imaging suggested the tumor was chondrosarcoma rather than a common enchondroma.
  • Histological examination revealed that the tumor was composed of polygonal cells with eosinophilic cytoplasm proliferating in the chondromatous matrix with partially myxoid changes.
  • Nuclear irregularity, binucleated cells, bone permeation and encasement were observed and the tumor was diagnosed as grade 2 chondrosarcoma.
  • The tumor recurred five months after surgery.
  • In conclusion, details of radiological as well as pathological findings are essential for differential diagnosis between benign enchondroma and chondrosarcoma in the hand.
  • [MeSH-major] Bone Neoplasms / pathology. Chondrosarcoma / pathology. Fingers / pathology. Review Literature as Topic
  • [MeSH-minor] Aged, 80 and over. Chondroma / diagnosis. Diagnosis, Differential. Disease-Free Survival. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Time Factors. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16498237.001).
  • [ISSN] 0040-8727
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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48. Behzatoğlu K, Durak H, Canberk S, Aydin O, Huq GE, Oznur M, Ozyalvaçli G, Yildiz P: Giant cell tumor-like lesion of the urinary bladder: a report of two cases and literature review; giant cell tumor or undifferentiated carcinoma? Diagn Pathol; 2009;4:48
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  • [Title] Giant cell tumor-like lesion of the urinary bladder: a report of two cases and literature review; giant cell tumor or undifferentiated carcinoma?
  • Giant cell tumor, excluding its prototype in bone, is usually a benign but local aggressive neoplasm originating from tendon sheath or soft tissue.
  • Giant cell tumors in visceral organs usually accompany epithelial tumors and the clinical behavior of giant cell tumor in urinary bladder is similar to its bone counterpart.
  • Here, we report two cases of giant cell tumor located in urinary bladder in comparison with nine reported cases in the English literature.
  • One of the two cases we present had no concurrent urothelial tumor at the time of diagnosis but had a history of a low grade noninvasive urothelial carcinoma with three recurrences.
  • The histology of these two cases was similar to the giant cell tumor of bone and composed of oval to spindle mononuclear cells with evenly spaced osteoclast-like giant cells.
  • The histologic and immunohistochemical properties in our cases as well as their clinical courses were consistent with a giant cell tumor.
  • Consequently, tumors in urinary bladder showing features of giant cell tumor of bone may also be considered and termed "giant cell tumor".

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  • (PMID = 20043822.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2811699
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49. Cheng L, Foster SR, MacLennan GT, Lopez-Beltran A, Zhang S, Montironi R: Inflammatory myofibroblastic tumors of the genitourinary tract--single entity or continuum? J Urol; 2008 Oct;180(4):1235-40
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  • PURPOSE: Inflammatory myofibroblastic tumor of the genitourinary tract is a spindled soft tissue lesion that is often mistaken for sarcoma.
  • The relationship between inflammatory myofibroblastic tumor and other morphologically similar entities has been a long-standing source of controversy.
  • We investigated whether inflammatory myofibroblastic tumors in adults and children are the same entity, and whether inflammatory myofibroblastic tumor is part of a biological spectrum that includes benign and malignant entities at opposite ends.
  • CONCLUSIONS: Inflammatory myofibroblastic tumor of the genitourinary tract should be considered a neoplasm of uncertain malignant potential, and routine surveillance and close clinical followup are recommended.
  • Aggressive therapy (radical cystectomy, radiation or chemotherapy) is unwarranted given the indolent and often benign clinical course for the majority of cases.
  • [MeSH-major] Carcinoma / pathology. Granuloma, Plasma Cell / pathology. Sarcoma / pathology. Urogenital Neoplasms / pathology
  • [MeSH-minor] Biopsy, Needle. Diagnosis, Differential. Humans. Immunohistochemistry. Incidence. Neoplasm Staging. Prognosis. Risk Assessment. Ureteral Neoplasms / diagnosis. Ureteral Neoplasms / pathology. Urethral Neoplasms / diagnosis. Urethral Neoplasms / pathology. Urinary Bladder Neoplasms / diagnosis. Urinary Bladder Neoplasms / pathology

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  • (PMID = 18707729.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 40
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50. Ergun T, Lakadamyali H, Derincek A, Tarhan NC, Ozturk A: Magnetic resonance imaging in the visualization of benign tumors and tumor-like lesions of hand and wrist. Curr Probl Diagn Radiol; 2010 Jan-Feb;39(1):1-16
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  • [Title] Magnetic resonance imaging in the visualization of benign tumors and tumor-like lesions of hand and wrist.
  • The differential diagnosis of benign tumors and tumor-like lesions of the hand and wrist region is important with regard to choosing the therapy (medical versus surgical), or to decide to just follow-up the lesion.
  • In most of the cases the proper analysis of MRI findings in correlation with the patient's history is sufficient to meet a specific diagnosis.
  • This pictorial essay offers a practical radiological approach to benign tumors and tumor-like lesions of the hand and wrist region based on most frequently observed MRI findings.
  • [MeSH-major] Hand / pathology. Magnetic Resonance Imaging / methods. Soft Tissue Neoplasms / diagnosis. Wrist / pathology
  • [MeSH-minor] Adult. Aged. Arteriovenous Malformations / diagnosis. Contrast Media. Diagnosis, Differential. Female. Giant Cell Tumors / diagnosis. Humans. Image Enhancement / methods. Lipoma / diagnosis. Male. Middle Aged. Neoplasm Staging. Young Adult

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  • (PMID = 19931109.001).
  • [ISSN] 1535-6302
  • [Journal-full-title] Current problems in diagnostic radiology
  • [ISO-abbreviation] Curr Probl Diagn Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 49
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51. Minagawa T, Matsushita K, Shimada R, Takayama H, Hiraga R, Uehara T, Murata Y: Aggressive angiomyxoma mimicking inguinal hernia in a man. Int J Clin Oncol; 2009 Aug;14(4):365-8
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  • Local excision was performed, with a preoperative diagnosis of benign soft tissue tumor.
  • Histopathological diagnosis revealed aggressive angiomyxoma (AAM), and no recurrence was observed 6 months after surgery.
  • AAM is a rare tumor which most commonly occurs in the pelvis or perineum of premenopausal women, with extremely rare cases in men.
  • The findings from previously reported cases and our case suggest that AAM should be considered in patients with an inguinal or scrotal swelling with a suspicious soft tissue tumor.
  • [MeSH-major] Hernia, Inguinal / diagnosis. Myxoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Treatment Outcome

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  • (PMID = 19705250.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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52. Börüban S, Sancak T, Yildiz Y, Sağlik Y: Embolization of benign and malignant bone and soft tissue tumors of the extremities. Diagn Interv Radiol; 2007 Sep;13(3):164-71
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  • [Title] Embolization of benign and malignant bone and soft tissue tumors of the extremities.
  • PURPOSE: To reveal the effectiveness and reliability of preoperative, curative, and palliative embolization of benign and malignant bone and soft tissue tumors of the extremities.
  • MATERIALS AND METHODS: Diagnostic angiography was performed on 35 patients (14 females, 40%; 21 males, 60%) between 6 and 70 years of age (mean, 32 years) who were referred to our digital subtraction angiography (DSA) unit between March 2000 and March 2004, and had extremity bone or soft tissue tumors.
  • Two other patients had surgical procedures after finding their lesions had increased in size.
  • CONCLUSION: Pre-operative, palliative, and curative selective/superselective intra-arterial embolization is an effective and potentially developing method for benign and malignant, hypervascularized bone and soft tissue tumors of the extremities, when it is performed by an experienced team with proper embolizing agents.
  • [MeSH-major] Bone Neoplasms / epidemiology. Bone Neoplasms / therapy. Embolization, Therapeutic / utilization
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Metastasis. Tomography, X-Ray Computed. Turkey / epidemiology

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  • (PMID = 17846993.001).
  • [ISSN] 1305-3825
  • [Journal-full-title] Diagnostic and interventional radiology (Ankara, Turkey)
  • [ISO-abbreviation] Diagn Interv Radiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Turkey
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53. Canavese F, Soo BC, Chia SK, Krajbich JI: Surgical outcome in patients treated for hemangioma during infancy, childhood, and adolescence: a retrospective review of 44 consecutive patients. J Pediatr Orthop; 2008 Apr-May;28(3):381-6
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  • BACKGROUND: Hemangiomas are the most common tumors in infancy and childhood and account for 7% of benign soft tissue tumors.
  • Diagnosis is usually made in infancy or childhood.
  • There are only a few reports on the surgical treatment of these lesions, likely because the lesions are quite vascular, have a tendency to infiltrate into the muscle and other tissues, and the recurrence rate is quite high.
  • Asymptomatic lesions should be monitored to confirm the diagnosis and to look for signs of progression.
  • A marginal resection may be used to treat most superficial soft tissue tumors.
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Child. Child, Preschool. Female. Hemangioma, Cavernous / diagnosis. Hemangioma, Cavernous / surgery. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / epidemiology. Retrospective Studies. Treatment Outcome

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  • (PMID = 18362808.001).
  • [ISSN] 0271-6798
  • [Journal-full-title] Journal of pediatric orthopedics
  • [ISO-abbreviation] J Pediatr Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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54. Khong JJ, Chen CS, James CL, Huilgol SC, O'Donnell BA, Sullivan TJ, Selva D: Malignant fibrous histiocytoma of the eyelid: differential diagnosis and management. Ophthal Plast Reconstr Surg; 2005 Mar;21(2):103-8
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  • [Title] Malignant fibrous histiocytoma of the eyelid: differential diagnosis and management.
  • PURPOSE: Malignant fibrous histiocytoma (MFH) is a pleomorphic soft tissue sarcoma that occurs rarely in the periocular region.
  • The purpose of this study was to present a case series of periocular MFH and to discuss the differential diagnosis and management.
  • There were no distant metastases or tumor-related deaths.
  • CONCLUSIONS: This study highlights the difficulties in the clinicopathologic diagnosis of periocular MFH and in particular the distinction of more superficial tumors from atypical fibroxanthoma.
  • [MeSH-major] Eyelid Neoplasms / diagnosis. Eyelid Neoplasms / surgery. Histiocytoma, Benign Fibrous / diagnosis. Histiocytoma, Benign Fibrous / surgery
  • [MeSH-minor] Aged. Aged, 80 and over. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Lymphatic Metastasis. Male. Neoplasm Recurrence, Local. Ophthalmologic Surgical Procedures. Radiotherapy, Adjuvant. Retrospective Studies

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  • (PMID = 15778662.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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55. Hong R, Lim SC: Granular cell tumor of the cecum with extensive hyalinization and calcification: a case report. World J Gastroenterol; 2009 Jul 14;15(26):3315-8
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  • [Title] Granular cell tumor of the cecum with extensive hyalinization and calcification: a case report.
  • A granular cell tumor (GCT) is a benign neoplasm of unclear histogenesis that is generally believed to be of nerve sheath origin.
  • GCT is not common and most often affects the tongue, skin and soft tissue, although it may occur anywhere in the body.
  • In addition to the tumor, endoscopic examination revealed the presence of a 5-mm-polyp in the descending colon and multiple tiny polyps in the sigmoid colon and rectum.
  • Histological examination demonstrated a cecal tumor 1.5 cm x 1.0 cm x 0.7 cm with a hard consistency; in cut sections, mixed cells with yellowish and whitish portions were seen.
  • The tumor was located between the mucosa and subserosa, and was composed of plump histiocyte-like tumor cells with abundant granular eosinophilic cytoplasm, which were immunoreactive for S-100 protein, vimentin, neuron-specific enolase, inhibin-alpha and calretinin.
  • The tumor showed extensive hyalinization and focal dystrophic calcification.
  • Extensive hyalinization and calcification showing involution of tumor cells suggest benign clinical behavior of GCT.
  • [MeSH-major] Calcinosis / pathology. Cecum / pathology. Granular Cell Tumor / pathology. Hyalin / metabolism
  • [MeSH-minor] Biomarkers, Tumor. Calbindin 2. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / pathology. Humans. Male. Middle Aged. Phosphopyruvate Hydratase. S100 Calcium Binding Protein G. S100 Proteins. Vimentin

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  • (PMID = 19598311.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / S100 Calcium Binding Protein G; 0 / S100 Proteins; 0 / Vimentin; EC 4.2.1.11 / Phosphopyruvate Hydratase
  • [Other-IDs] NLM/ PMC2710791
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56. Lu C, Ji Y, Shan F, Guo W, Ding J, Ge D: Solitary fibrous tumor of the pleura: an analysis of 13 cases. World J Surg; 2008 Aug;32(8):1663-8
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  • [Title] Solitary fibrous tumor of the pleura: an analysis of 13 cases.
  • BACKGROUND: Solitary fibrous tumor of the pleura is a rare soft-tissue tumor.
  • In search of appropriate diagnosis and treatment methods, we present our experience with 13 patients.
  • Seven tumors were malignant and the other six were benign.
  • CONCLUSION: Ultrasonography-guided core needle biopsy combined with immunohistochemical analysis might be a safe and rapid method to provide a confirmatory diagnosis before resection.
  • We speculate that CD34-negative and nestin-positive might be a malignant marker for solitary fibrous tumor of pleura.
  • [MeSH-major] Neoplasms, Fibrous Tissue / diagnosis. Neoplasms, Fibrous Tissue / surgery. Pleural Neoplasms / diagnosis. Pleural Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Biopsy, Needle / methods. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Metastasis. Radiography, Thoracic. Thoracic Surgery, Video-Assisted. Tomography, X-Ray Computed. Ultrasonography, Interventional

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  • (PMID = 18427887.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 20
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57. Capodiferro S, Maiorano E, Scarpelli F, Favia G: Fibrolipoma of the lip treated by diode laser surgery: a case report. J Med Case Rep; 2008;2:301
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  • INTRODUCTION: Several neoplasms of the adipose tissue can involve the soft tissues of the head and neck region.
  • These neoplasms are mainly treated surgically and an accurate histological examination is mandatory for a precise diagnosis.
  • This approach allowed adequate resection of the neoplasm with minimal damage to the adjacent tissues, thus reducing post-surgical scarring.
  • CONCLUSION: Diode laser surgery for the treatment of benign lesions of the oral mucosa appears to be a convenient alternative to conventional blade surgery and has proved to be effective for the excision of fibrolipoma of the lip.

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  • (PMID = 18789134.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2547114
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58. Delfino S, Toto V, Brunetti B, Bianchi A, Baldi A, Persichetti P: Recurrent atypical eccrine spiradenoma of the forehead. In Vivo; 2008 Nov-Dec;22(6):821-3
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  • Eccrine spiradenoma is an uncommon but well recognized benign adnexal tumour of the eccrine sweat glands.
  • We report a case of eccrine spiradenoma in a thirty-six-year-old man who presented with a recurrent soft-tissue neoplasm of the forehead, with cytological atypia.
  • The differential diagnosis of this tumour, as well as its possible malignant transformation, is discussed.
  • [MeSH-major] Soft Tissue Neoplasms / surgery. Sweat Gland Neoplasms / surgery

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  • (PMID = 19181014.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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59. Murphy A, Williams J: Posterior interosseous nerve palsy caused by lipoma: A case report. Can J Plast Surg; 2009;17(4):e42-4
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  • Lipomas are benign soft tissue neoplasms that occur commonly in subcutaneous tissue.

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  • (PMID = 21119834.001).
  • [ISSN] 1918-1507
  • [Journal-full-title] The Canadian journal of plastic surgery = Journal canadien de chirurgie plastique
  • [ISO-abbreviation] Can J Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2827290
  • [Keywords] NOTNLM ; Forearm / Lipoma / Posterior interosseous nerve palsy
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60. Park JW, Namkoong S, Chung J, Jung KE, Oh SA, Cinn YW, Kim MH: A case of eccrine spiradenoma in a patient with neurofibromatosis. Ann Dermatol; 2010 May;22(2):191-3
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  • Neurofibromatosis is a systemic hereditary disorder with varied manifestations in bone, soft tissue, the nervous system and skin.
  • Some benign or malignant tumors such as juvenile xanthogranuloma, pheochromocytoma, and malignant melanoma can accompany neurofibromatosis.
  • Eccrine spiradenoma is a benign uncommon neoplasm of skin adnexa.

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  • (PMID = 20548911.001).
  • [ISSN] 2005-3894
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2883423
  • [Keywords] NOTNLM ; Eccrine spiradenoma / Neurofibromatosis
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61. Nikitakis NG, Argyris P, Sklavounou A, Papadimitriou JC: Oral myoepithelioma of soft tissue origin: report of a new case and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Nov;110(5):e48-51
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  • [Title] Oral myoepithelioma of soft tissue origin: report of a new case and literature review.
  • Oral myoepithelioma of soft tissue origin, an entity distinct from myoepithelioma of salivary glands, constitutes an extremely rare benign neoplasm, with only 1 previously published case, affecting the tongue of a 22-year-old woman.
  • Ectomesenchymal chondromyxoid tumour (ECT) also is a very rare benign neoplasm of the oral cavity that has a strong predilection for the anterior dorsum of the tongue.
  • The great similarities in the histologic and immunohistochemical characteristics of soft tissue myoepithelioma (STM) and ECT probably indicate that they refer to the same or closely related pathologic entities.
  • [MeSH-major] Myoepithelioma / diagnosis. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Actins / analysis. Antigens, CD57 / analysis. Cell Nucleus / ultrastructure. Chromatin / ultrastructure. Cytoplasm / ultrastructure. Desmin / analysis. Diagnosis, Differential. Glial Fibrillary Acidic Protein / analysis. Humans. Male. Middle Aged. Mouth Mucosa / pathology. Muscle, Skeletal / pathology. Neoplasms, Complex and Mixed / diagnosis. S100 Proteins / analysis. Vimentin / analysis

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  • [Copyright] Copyright © 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20955943.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD57; 0 / Chromatin; 0 / Desmin; 0 / Glial Fibrillary Acidic Protein; 0 / S100 Proteins; 0 / Vimentin
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62. Liu FH, Hsueh C, Chao TC, Lin JD: Neck nodule and thyroid cancer in young without radiation exposure history. Pediatr Surg Int; 2009 Sep;25(9):785-8
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  • Neck ultrasonography studies were conducted using a real-time ultrasonographic machine and a 10 MHz transducer.
  • RESULTS: Of the 234 cases, 187 (79.9%) were surgically confirmed to be benign lesions, including four cases that were diagnosed as atypical adenoma.
  • Surgery confirmed 22 cases to be lesions that were non-thyroid in origin, including those developing from a cyst, soft tissue, and with a lymphatic origin.
  • Except in cases of follicular thyroid neoplasm, neck ultrasonography with FNAC could effectively identify the thyroid or non-thyroid origin of these masses with high-diagnostic accuracy.
  • [MeSH-major] Head and Neck Neoplasms / pathology

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  • (PMID = 19629501.001).
  • [ISSN] 1437-9813
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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63. Mentzel T, Dei Tos AP, Sapi Z, Kutzner H: Myopericytoma of skin and soft tissues: clinicopathologic and immunohistochemical study of 54 cases. Am J Surg Pathol; 2006 Jan;30(1):104-13
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  • [Title] Myopericytoma of skin and soft tissues: clinicopathologic and immunohistochemical study of 54 cases.
  • Perivascular neoplasms comprise traditionally glomus tumor and hemangiopericytoma (HPC).
  • Whereas glomus tumor represents a well-defined entity, the existence of HPC as a separate entity has been questioned because a number of neoplasms of different lines of differentiation are characterized by a HPC-like vascular growth pattern.
  • A large series of myopericytoma of skin and soft tissues has been analyzed to further characterize the clinicopathologic spectrum of this entity.
  • Fifty-four cases of myopericytoma of skin and soft tissues were retrieved and the histology reviewed.
  • In 20 cases, the neoplasms were confined to the dermis, in 6 cases an extension into the subcutis was seen, and 24 as well as 4 cases arose in subcutaneous and deep soft tissue, respectively.
  • Histologically, in all cases, numerous thin-walled vessels and a concentric, perivascular arrangement of ovoid, plump spindled to round myoid tumor cells was seen.
  • However, a broad morphologic spectrum ranging from hypocellular, fibroma-like (3 cases), myofibroma-like (2 cases), angioleiomyoma-like (12 cases), and HPC-like neoplasms (13 cases) to classic myopericytomas (14 cases) and immature, cellular lesions (2 cases) was noted.
  • In addition, 2 neoplasms with focal glomoid features, 5 intravascular, and 1 malignant myopericytomas were found.
  • Despite marginal or incomplete excision in 23 of 46 cases, only 2 neoplasms (1 malignant and 1 intravascular myopericytoma) recurred locally (within 1 and 4 years, respectively).
  • Despite overlapping morphologic features to angioleiomyoma and myofibroma, myopericytoma represents a distinct perivascular, myoid neoplasm of skin and soft tissues, characterized by a broad morphologic spectrum of concentrically, perivascularly growing myoid tumor cells that stain positively for ASMA and often for h-caldesmon, whereas desmin is usually negative.
  • Most cases of myopericytoma behave in a benign fashion, but local recurrences and rarely metastases may occur in atypical and malignant neoplasms.
  • [MeSH-major] Biomarkers, Tumor / analysis. Neoplasms, Vascular Tissue / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Angiomyoma / pathology. Diagnosis, Differential. Female. Glomus Tumor / pathology. Hemangiopericytoma / metabolism. Hemangiopericytoma / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Myofibroma / pathology

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  • (PMID = 16330949.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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64. Nyman HT, Kristensen AT, Lee MH, Martinussen T, McEvoy FJ: Characterization of canine superficial tumors using gray-scale B mode, color flow mapping, and spectral doppler ultrasonography--a multivariate study. Vet Radiol Ultrasound; 2006 Mar-Apr;47(2):192-8
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  • The objectives of this study were to characterize the ultrasonographic patterns of superficial tumors and to evaluate whether ultrasound can help discriminate between benign and malignant tumors in dogs.
  • Size, echogenicity, tumor border definition, invasiveness, acoustic transmission, presence and distribution of vascular flow to and within the tumor, as well as perfusion indices were measured.
  • The tumors were classified as lipomas, benign tumors, atypical mammary tumors, and malignant tumors.
  • Multivariate statistics using discriminant analysis was used to determine which parameters may be used to predict the status of the tumor.
  • Tumor echogenicity, border shape, acoustic shadowing, total number of vessels to the tumor and the total flow amount are the parameters that in combination resulted in the lowest classification error (24%), meaning that on average three out of four tumors were correctly classified using these parameters.
  • The results of this study show that ultrasonography has an important role in the evaluation of canine superficial tumors, particularly in the evaluation of tissue homogeneity and tumor vascularity.
  • [MeSH-major] Dog Diseases / ultrasonography. Lipoma / veterinary. Soft Tissue Neoplasms / veterinary
  • [MeSH-minor] Animals. Dogs. Female. Male. Multivariate Analysis. Neoplasm Metastasis. Predictive Value of Tests. Pulsatile Flow. Regional Blood Flow. Ultrasonography, Doppler, Color / veterinary

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  • (PMID = 16553153.001).
  • [ISSN] 1058-8183
  • [Journal-full-title] Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
  • [ISO-abbreviation] Vet Radiol Ultrasound
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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65. Mack LA, Crowe PJ, Yang JL, Schachar NS, Morris DG, Kurien EC, Temple CL, Lindsay RL, Magi E, DeHaas WG, Temple WJ: Preoperative chemoradiotherapy (modified Eilber protocol) provides maximum local control and minimal morbidity in patients with soft tissue sarcoma. Ann Surg Oncol; 2005 Aug;12(8):646-53
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  • [Title] Preoperative chemoradiotherapy (modified Eilber protocol) provides maximum local control and minimal morbidity in patients with soft tissue sarcoma.
  • BACKGROUND: Local recurrence rates of 15% to 30% after treatment of soft tissue sarcoma (STS) are still common but unacceptable.
  • Risk factors for death included tumor stage (hazard ratio, 1.54; P = .001) and tumor grade (hazard ratio, 1.4; P = .02).
  • Three patients (4%) required reoperation for tissue loss, and eight patients (10.6%) developed minor wound complications.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antibiotics, Antineoplastic / administration & dosage. Chemotherapy, Adjuvant. Doxorubicin / administration & dosage. Female. Histiocytoma, Benign Fibrous / pathology. Histiocytoma, Benign Fibrous / surgery. Histiocytoma, Benign Fibrous / therapy. Humans. Leiomyosarcoma / pathology. Leiomyosarcoma / surgery. Leiomyosarcoma / therapy. Liposarcoma / pathology. Liposarcoma / surgery. Liposarcoma / therapy. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies


66. Wu CW, Chi HP, Chiang FY, Hsu YC, Chan LP, Kuo WR: Giant lipoma arising from deep lobe of the parotid gland. World J Surg Oncol; 2006;4:28
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  • BACKGROUND: Lipomas are common benign soft tissue neoplasms but they are found very rarely in the deep lobe of parotid gland.

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  • (PMID = 16740172.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
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67. Nigri G, Dente M, Valabrega S, Beccaria G, Aurello P, D'Angelo F, Di Marzo F, Ramacciato G: Giant inframuscular lipoma disclosed 14 years after a blunt trauma: a case report. J Med Case Rep; 2008;2:318
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  • INTRODUCTION: Lipoma is the most frequent benign tumor of the soft tissue.
  • Although the diagnosis is mostly clinical, imaging tools are useful to confirm the adipose nature of the lesion and to define its anatomic border.

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  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
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68. Leti Acciaro A, Gabrieli R, Landi A: A rare case of acral myxoinflammatory fibroblastic sarcoma at the hand. Musculoskelet Surg; 2010 May;94(1):53-7
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  • Most of the soft tissue tumefactions of the distal extremities are benign.
  • Acral myxoinflammatory fibroblastic sarcoma is a unique low-grade tumor described by Kindblom in 1998.
  • This neoplasm has a propensity for digits, presents a low rate of metastasis and is characterized by a high rate of local multiple and aggressive recurrence.
  • Correct and early diagnosis depends on a good knowledge of histological and immunohistochemical findings.
  • It is important to avoid recurrences recurring to an immediate wide excision of the tumor.
  • [MeSH-major] Fingers. Myxosarcoma / diagnosis

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  • (PMID = 20066525.001).
  • [ISSN] 2035-5114
  • [Journal-full-title] Musculoskeletal surgery
  • [ISO-abbreviation] Musculoskelet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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69. Maghari A, Ma N, Aisner S, Benevenia J, Hameed M: Collagenous fibroma (desmoplastic fibroblastoma) with a new translocation involving 11q12: a case report. Cancer Genet Cytogenet; 2009 Jul 15;192(2):73-5
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  • Collagenous fibroma (or desmoplastic fibroblastoma) is a rare, benign tumor usually centered in the subcutaneous tissue composed of spindle-shaped to stellate fibroblasts and myofibroblasts in a densely collagenous background.
  • Herein, we report a case of collagenous fibroma of deep soft tissue with t(11;17)(q12;p11.2).
  • The breakpoint at chromosome 11q12 appears to be pathogenetic in this rare neoplasm.
  • [MeSH-major] Chromosomes, Human, Pair 11 / genetics. Collagen / metabolism. Fibroma / genetics. Soft Tissue Neoplasms / genetics. Translocation, Genetic

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  • (PMID = 19596257.001).
  • [ISSN] 1873-4456
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-34-5 / Collagen
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70. Ui M, Ogawa K: Subdeltoid lipoma: a case with symptoms mimicking glenohumeral instability and subacromial impingement. Orthopedics; 2010 Jun;33(6):443
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  • Lipoma is the most frequently occurring benign soft tissue tumor in the shoulder and the axillary region in middle-aged and older persons, yet few such lipoma cases have been associated with clinical symptoms.
  • A 38-year-old right-handed man presented with an enlarged feeling and a painful back-and-forth popping in his left shoulder.
  • Magnetic resonance imaging showed a homogenous tumor in the subdeltoid that was isointense relative to the subcutaneous fat and fluid collection in the hypertrophic subacromial bursa.
  • As the tumor was considered from the clinical and imaging findings to be attributable to all clinical symptoms, it was resected en bloc with a satisfactory result.
  • Histopathologically, the tumor showed typical features of a simple lipoma.
  • [MeSH-major] Lipoma / diagnosis. Muscle Neoplasms / diagnosis. Shoulder Dislocation / diagnosis. Shoulder Impingement Syndrome / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Shoulder

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  • [Copyright] Copyright 2010, SLACK Incorporated.
  • (PMID = 20806760.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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71. Jani DR, Chawda J, Sundaragiri SK, Parmar G: Mucocele--a study of 36 cases. Indian J Dent Res; 2010 Jul-Sep;21(3):337-40
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  • BACKGROUND: Mucocele is one of the most common benign soft tissue tumor present in the oral cavity.
  • The clinical data were recorded and histopathologic diagnosis was made.
  • RESULTS: A diagnosis of mucocele was established in 36 cases with male-to-female ratio of 1.77:1.

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  • (PMID = 20930340.001).
  • [ISSN] 1998-3603
  • [Journal-full-title] Indian journal of dental research : official publication of Indian Society for Dental Research
  • [ISO-abbreviation] Indian J Dent Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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72. Sari A, Tunakan M, Bolat B, Cakmakçi H, Ozer E: Lipofibromatosis in a two-year-old girl: a case report. Turk J Pediatr; 2007 Jul-Sep;49(3):319-21
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  • Lipofibromatosis is a recently described rare benign soft tissue tumor of childhood.
  • The tumor has a high rate of non-destructive recurrence, but there is no metastatic potential.
  • [MeSH-major] Fibroma / pathology. Neoplasm Recurrence, Local / surgery

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  • (PMID = 17990590.001).
  • [ISSN] 0041-4301
  • [Journal-full-title] The Turkish journal of pediatrics
  • [ISO-abbreviation] Turk. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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73. Levi PA Jr, Kim DM, Harsfield SL, Jacobson ER: Squamous cell carcinoma presenting as an endodontic-periodontic lesion. J Periodontol; 2005 Oct;76(10):1798-804
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  • BACKGROUND: Regardless of advances in diagnosis and treatment during the past 40 years, the overall 5-year survival rates for oral and oropharyngeal squamous cancers have only slightly improved and remain around 50%.
  • Thus, the early diagnosis and treatment of carcinoma by health care providers are essential in achieving a good prognosis.
  • We report a case of invasive squamous cell carcinoma that presented as a benign endodontic-periodontic lesion with a 7-mm periodontal pocket on tooth #15 in a 40-year-old, non-smoking woman.
  • A periodontal flap surgical procedure was performed on teeth #13 to #15, and as there was bone erosion into the maxillary sinus, a biopsy of the soft tissue was submitted to the local hospital for histological analysis.
  • The patient remained free of tumor for 5 years after the initial presentation.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Gingival Neoplasms / pathology. Maxillary Neoplasms / pathology. Periodontal Cyst / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Maxillary Sinus Neoplasms / pathology. Neoplasm Invasiveness / pathology

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  • (PMID = 16253104.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Habibi Z, Nejat F, Naeini PE, Mahjoub F: Teratoma inside a myelomeningocele. J Neurosurg; 2007 Jun;106(6 Suppl):467-71
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  • The coincidence of an MMC and a neoplasm is rare, and only limited reports on the concurrence of a teratoma within an MMC have been published.
  • Physical appearance of the teratoma in all cases included cystic or solid soft-tissue masses in the dorsal midline area, covered with abnormal rudimentary skin.
  • Teratoma inside an MMC is a benign neoplasm, without any recurrence after standard surgery for an MMC.
  • [MeSH-major] Central Nervous System Neoplasms / complications. Meningomyelocele / complications. Teratoma / complications

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  • (PMID = 17566404.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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75. Duncan L, Tharp DR, Branca P, Lyons J: Endobronchial perineurioma: an unusual soft tissue lesion in an unreported location. Patholog Res Int; 2010;2010:613824
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  • [Title] Endobronchial perineurioma: an unusual soft tissue lesion in an unreported location.
  • We report the first case of an endobronchial perineurioma, a rare benign neoplasm typically occurring in soft tissue.
  • The tumor was composed of bland spindle cells in a variably collagenized stroma.
  • Based on the morphologic appearance and immunophenotype, a diagnosis of perineurioma was rendered.

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  • (PMID = 21151724.001).
  • [ISSN] 2042-003X
  • [Journal-full-title] Pathology research international
  • [ISO-abbreviation] Patholog Res Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2990242
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76. Kabukcuoglu F, Kabukcuoglu Y, Tanik C, Sakiz D, Karsidag S: Breast carcinoma metastasis in recurrent myxoid liposarcoma. Pathol Oncol Res; 2009 Sep;15(3):467-71
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  • Tumor to tumor metastasis is a rare, but well recognized entity, most commonly involving a carcinoma metastasis to a benign or low grade mesenchymal tumor.
  • The tumor recurred twice and was reexcised.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / pathology. Liposarcoma, Myxoid / pathology. Neoplasms, Second Primary / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols. Combined Modality Therapy. Fatal Outcome. Female. Humans. Immunohistochemistry. Mastectomy. Middle Aged. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Radiotherapy


77. Nakashima K, Yamada N, Yoshida Y, Yamamoto O: Solitary sclerotic neurofibroma of the skin. Am J Dermatopathol; 2008 Jun;30(3):278-80
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  • Solitary neurofibroma of the skin is a benign soft tissue tumor.
  • Clinically, it is a flesh-colored, slow-growing, soft tumor and sometimes shows diverse histological patterns.
  • Our findings suggest that mast cells may have played a role in the formation of the sclerotic regions of the current tumor.
  • [MeSH-major] Neurofibroma / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Aged. Collagen / metabolism. Dermis / pathology. Female. Humans. Mast Cells / pathology. Sclerosis / metabolism. Sclerosis / pathology. Subcutaneous Tissue / pathology

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  • (PMID = 18496433.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-34-5 / Collagen
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78. Schmitz S, Weynand B, Lengelé B, Hamoir M: Solitary fibrous tumour of the soft tissue of the face: a case report. B-ENT; 2006;2(4):201-4
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  • [Title] Solitary fibrous tumour of the soft tissue of the face: a case report.
  • INTRODUCTION: Solitary fibrous tumour (SFT) is a rare mesenchymal neoplasm described first in the pleura.
  • Preoperative cytological examination by fine needle aspiration biopsy diagnosed a mesenchymal tumour.
  • Definitive histopathologic and immunohistologic examination confirmed the diagnosis of SFT.
  • DISCUSSION: The rare localisation in extrapleural sites and the multiplicity of histological patterns can explain the difficulty in arriving at a definitive diagnosis in SFT.
  • Usually, SFT is a benign tumour, although malignant variants exist.
  • The recent increase in reports of extrapleural SFT indicates that this rare tumour should be included in the differential diagnosis of soft tissue head and neck tumours.
  • [MeSH-major] Facial Neoplasms / pathology. Neoplasms, Fibrous Tissue / pathology
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Dermatofibrosarcoma / diagnosis. Diagnosis, Differential. Female. Hemangiopericytoma / diagnosis. Humans. Treatment Outcome

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  • (PMID = 17256410.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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79. Murphey MD: World Health Organization classification of bone and soft tissue tumors: modifications and implications for radiologists. Semin Musculoskelet Radiol; 2007 Sep;11(3):201-14
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  • [Title] World Health Organization classification of bone and soft tissue tumors: modifications and implications for radiologists.
  • The working group of the World Health Organization (WHO) for classification of tumors of soft tissue and bone met in 2002.
  • The consensus of this conference led to modifications in the nomenclature primarily for soft tissue neoplasm, leaving osseous tumors largely unaltered.
  • This allows improved uniformity in our discussions with pathologists and orthopedic oncologists in our team approach in the diagnosis and treatment of these patients.
  • [MeSH-major] Bone Neoplasms / classification. Diagnostic Imaging. Soft Tissue Neoplasms / classification. World Health Organization
  • [MeSH-minor] Fibrosarcoma / classification. Histiocytoma, Benign Fibrous / classification. Humans. Liposarcoma / classification. Terminology as Topic


80. Balke M, Streitbuerger A, Budny T, Henrichs M, Gosheger G, Hardes J: Treatment and outcome of giant cell tumors of the pelvis. Acta Orthop; 2009 Oct;80(5):590-6
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  • METHODS: 20 patients with histologically benign GCT of the pelvis were included in this study.
  • RESULTS: 1 patient with a pubic tumor developed a local recurrence 1 year after intralesional resection and additional curettage of the margins.
  • The recurrence presented as a small soft tissue mass within the scar tissue of the gluteal muscles and was treated by resection.
  • [MeSH-major] Bone Neoplasms / surgery. Giant Cell Tumor of Bone / surgery. Pelvic Bones
  • [MeSH-minor] Adult. Aged. Bone Cements. Bone Transplantation. Curettage. Embolization, Therapeutic / methods. Female. Follow-Up Studies. Humans. Ilium / pathology. Ilium / surgery. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Radiotherapy, Adjuvant. Retrospective Studies. Treatment Outcome

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  • (PMID = 19916695.001).
  • [ISSN] 1745-3682
  • [Journal-full-title] Acta orthopaedica
  • [ISO-abbreviation] Acta Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bone Cements
  • [Other-IDs] NLM/ PMC2823344
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81. Bobbio A, Mazzeo A, Carbognani P, Rusca M: An unusual case of calcifying fibrous pseudotumour of the cervicothoracic junction. Eur J Cardiothorac Surg; 2008 Nov;34(5):1123-5
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  • Calcifying fibrous pseudotumour is a rare benign tumour of soft tissue origin, occasionally encountered in the thoracic cavity; surgical resection is considered the treatment of choice.
  • At surgery the tumour was found to circumferentially entrap the left subclavian artery and its removal involved segmental artery resection and reconstruction by autologous saphenous vein graft.

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  • (PMID = 18755598.001).
  • [ISSN] 1873-734X
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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82. Nguyen QH, Szeto E, Mansberg R, Mansberg V: Paravertebral infection (phlegmon) demonstrated by FDG dual-head coincidence imaging in a patient with multiple malignancies. Clin Nucl Med; 2005 Apr;30(4):241-3
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  • The scan appearance was suspicious for a localized soft tissue neoplasm.
  • An FDG coincidence positron emission tomography (PET) study demonstrated a large FDG-avid soft tissue abnormality.
  • Because FDG is not tumor-specific, accumulation in benign lesions may give rise to false-positive results despite a high pretest probability for malignancy.
  • [MeSH-major] Cellulitis / radionuclide imaging. Diagnostic Errors / prevention & control. Fluorodeoxyglucose F18. Lumbar Vertebrae / radionuclide imaging. Soft Tissue Neoplasms / radionuclide imaging. Staphylococcal Infections / radionuclide imaging
  • [MeSH-minor] Aged. Back Pain / diagnosis. Back Pain / etiology. Breast Neoplasms / complications. Breast Neoplasms / radionuclide imaging. Diagnosis, Differential. Female. Gamma Cameras. Humans. Melanoma / complications. Melanoma / radionuclide imaging. Radiopharmaceuticals

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  • (PMID = 15764879.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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83. Rohilla S, Yadav RK, Dhaulakhandi DB: Lipoma of Guyon's canal causing ulnar neuropathy. J Orthop Traumatol; 2009 Jun;10(2):101-3
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  • Lipoma is a benign soft tissue tumor which rarely causes neuropathy.

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  • (PMID = 19468684.001).
  • [ISSN] 1590-9921
  • [Journal-full-title] Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology
  • [ISO-abbreviation] J Orthop Traumatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2688595
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84. Rau T, Soeder S, Olk A, Aigner T: Parosteal lipoma of the thigh with cartilaginous and osseous differentiation: an osteochondrolipoma. Ann Diagn Pathol; 2006 Oct;10(5):279-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lipomas are very common benign soft tissue neoplasms.
  • Mature cartilage and bone arising in a lipoma is a rare event and is mostly associated with a parosteal localization of the neoplasm.
  • The occurrence of at least 4 distinct directions of mesenchymal cell differentiation within a benign neoplasia underlines the concept of multilineage differentiation of pluripotent mesenchymal stem cells.
  • Such a multidirectional potential was recently well established in vitro in stem cells present in adult adipocytic tissue.
  • [MeSH-major] Bone and Bones / pathology. Cartilage / pathology. Lipoma / pathology. Periosteum / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adipocytes / pathology. Aged. Cell Differentiation. Cell Transformation, Neoplastic / pathology. Diagnosis, Differential. Humans. Male. Mesenchymal Stromal Cells / pathology. Ossification, Heterotopic / pathology. Thigh

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  • (PMID = 16979520.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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85. Athwal GS, Bueno RA, Bansal M, Mintz DN, Athanasian EA: Intra-articular fibroma of tendon sheath involving the scapholunate and radiocarpal joints. Skeletal Radiol; 2006 Aug;35(8):599-602
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  • Fibroma of tendon sheath is an uncommon benign soft tissue tumor with a predilection for the hand.
  • Magnetic resonance imaging demonstrated a heterogeneous and lobulated mass with nonspecific signal characteristics closely associated with the scapholunate interval and the volar wrist soft tissues.
  • The tumor is discussed and the relevant literature is reviewed.
  • [MeSH-major] Fibroma / pathology. Soft Tissue Neoplasms / pathology. Wrist Joint / pathology

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  • (PMID = 16283174.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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86. Lim KJ, Moon JH, Yoon DY, Cha JH, Lee IJ, Min SJ: Angiomyofibroblastoma arising from the posterior perivesical space: a case report with MR findings. Korean J Radiol; 2008 Jul-Aug;9(4):382-5
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  • Angiomyofibroblastoma is a rare benign soft tissue neoplasm that predominantly occurs in the genital region of middle-aged women.
  • [MeSH-major] Angiofibroma / diagnosis. Angiomyoma / diagnosis. Magnetic Resonance Imaging. Vaginal Neoplasms / diagnosis

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  • (PMID = 18682679.001).
  • [ISSN] 1229-6929
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2627271
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87. Heffernan EJ, Hayes MM, Alkubaidan FO, Clarkson PW, Munk PL: Aggressive angiomyxoma of the thigh. Skeletal Radiol; 2008 Jul;37(7):673-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Aggressive angiomyxoma is a rare tumour that typically occurs in the perineum in women of reproductive age.
  • While benign, the tumour is locally infiltrative and consequently has a high rate of local recurrence following surgery; therefore, accurate pre-operative diagnosis is important.
  • We describe a case of aggressive angiomyxoma arising in the thigh of a 54-year-old man, which we believe is the first reported instance of this rare neoplasm occurring remote from the pelvis or perineum in a male patient.
  • At histological analysis, the tumour exhibited the characteristic features of aggressive angiomyxoma, with bland spindle cells and large, hyalinised blood vessels in a hypocellular myxoid matrix.
  • Extensive immunohistochemical staining further supported the diagnosis.
  • While the imaging features of these tumours are non-specific and suggestive of myxoid neoplasms, the diagnosis should be considered whenever biopsy of a myxoid-appearing mass yields hypocellular, non-diagnostic material, despite adequate sampling.
  • [MeSH-major] Magnetic Resonance Imaging. Myxoma / diagnosis. Soft Tissue Neoplasms / diagnosis. Thigh / diagnostic imaging. Thigh / pathology. Tomography, X-Ray Computed

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  • (PMID = 18338163.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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88. Fauth CT, Bruecks AK, Temple W, Arlette JP, DiFrancesco LM: Superficial leiomyosarcoma: a clinicopathologic review and update. J Cutan Pathol; 2010 Feb;37(2):269-76
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  • BACKGROUND: Superficial leiomyosarcomas (SLMSs) are rare soft tissue malignancies.
  • Fourteen tumors were confined to the dermis and 11 involved subcutaneous tissue.
  • Novel histological features included epidermal hyperplasia, sclerotic collagen bands and increasing tumor grade with the depth of the lesion.
  • SLMS can appear low grade or even benign on superficial biopsies, leading to undergrading or a delay in the correct diagnosis.
  • [MeSH-major] Leiomyosarcoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Proteins / metabolism. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Treatment Outcome

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  • (PMID = 19694881.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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89. McGough RL, Rutledge J, Lewis VO, Lin PP, Yasko AW: Impact severity of local recurrence in giant cell tumor of bone. Clin Orthop Relat Res; 2005 Sep;438:116-22
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  • [Title] Impact severity of local recurrence in giant cell tumor of bone.
  • We retrospectively reviewed 183 consecutive patients diagnosed with giant cell tumor at the three most common sites (distal femur, proximal tibia, and distal radius) to determine the pattern of local tumor recurrence and the impact severity of the recurrence on adjacent joint function.
  • The primary tumor was treated in all patients with intralesional excision of tumor by curettage.
  • Twenty-three of the patients had their first surgery at our institution, and 22 had been referred from other institutions after the development of local recurrence.
  • The intrainstitutional recurrences were salvaged by a repeat curettage (n = 12) or en bloc osteoarticular resection (n = 10) for bone recurrences and wide local excision for soft tissue recurrence (n = 1).
  • Incomplete initial surgery, a delay in diagnosis of the recurrence of greater than 6 months, and subchondral recurrence of tumor were contributing factors in the failure to salvage the joint.
  • Despite its benign histology, giant cell tumor of bone is an aggressive tumor that demands meticulous attention to surgical detail and close postoperative surveillance for successful local tumor control and durable, joint-preserving function.
  • [MeSH-major] Bone Neoplasms / pathology. Giant Cell Tumor of Bone / pathology. Neoplasm Recurrence, Local

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  • (PMID = 16131879.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Sailon AM, Cappuccino G, Hameed M, Fleegler EJ: Nodular fasciitis of the hand over the metacarpophalangeal joint: a case report. Eplasty; 2008;8:e38
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: This study describes a case of nodular fasciitis involving the hand and reviews the neoplasm's pertinent clinical, histologic, and pathologic features.
  • CONCLUSIONS: Nodular fasciitis is a self-limited, benign soft tissue tumor composed of fibroblasts and myofibroblasts that typically afflicts younger patients and rarely presents in the hand.
  • Because of its presentation, it can be easily mistaken for a malignant neoplasm.

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  • [Cites] Orthop Clin North Am. 2006 Jan;37(1):53-63 [16311111.001]
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  • (PMID = 18725954.001).
  • [ISSN] 1937-5719
  • [Journal-full-title] Eplasty
  • [ISO-abbreviation] Eplasty
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2491338
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91. Dias PF, Pedro Rde L, Janine ME, Maia LC: Congenital epulis: an unusual case of spontaneous regression. Gen Dent; 2008 Jul-Aug;56(5):e25-7
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  • Congenital epulis is a rare benign neoplasm of the soft tissues.
  • [MeSH-major] Gingival Neoplasms / congenital. Neoplasm Regression, Spontaneous / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Follow-Up Studies. Humans. Infant

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  • (PMID = 21444268.001).
  • [ISSN] 0363-6771
  • [Journal-full-title] General dentistry
  • [ISO-abbreviation] Gen Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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92. Gaeta M, Mazziotti S, Minutoli F, Genitori A, Toscano A, Rodolico C, Blandino A: MR imaging findings of focal myositis: a pseudotumour that may mimic muscle neoplasm. Skeletal Radiol; 2009 Jun;38(6):571-8
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  • [Title] MR imaging findings of focal myositis: a pseudotumour that may mimic muscle neoplasm.
  • Dynamic enhancement pattern corresponded to the type usually seen in benign soft tissue lesions.
  • CONCLUSION: Focal myositis is an uncommon pseudotumour which should be considered in the differential diagnosis of muscular masses and myopathies.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Muscle Neoplasms / pathology. Muscle, Skeletal / pathology. Myositis / pathology
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Young Adult

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  • (PMID = 19255757.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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93. Ronaghy A, Yaar R, Goldberg LJ, Mahalingam M, Bhawan J: Perineural involvement: what does it mean? Am J Dermatopathol; 2010 Jul;32(5):469-76
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  • Perineural invasion is an important mechanism for local spread in certain malignant cutaneous neoplasms and is associated with aggressive tumor growth, increased frequency of recurrence, and increased morbidity and mortality.
  • There exists, however, a limited number of cutaneous and noncutaneous benign neoplasms in addition to reactive lesions that either demonstrates perineural involvement or mimics it.
  • Given the association of the term "invasion" with malignant neoplasms, we use the term "perineural involvement" to describe neoplastic cells of any type infiltrating within nerves.
  • Despite the presence of perineural involvement in these benign lesions, there is no evidence of aggressive behavior compared with similar examples which do not demonstrate perineural involvement.
  • The aim of this article is to review cutaneous and noncutaneous benign neoplasms and reactive conditions that may demonstrate or mimic perineural involvement.
  • Recognition of the spectrum of benign processes that may resemble perineural involvement may help prevent diagnostic confusion, misdiagnosis, and overly aggressive treatment.
  • [MeSH-major] Neoplasms / pathology. Nerve Sheath Neoplasms / pathology. Peripheral Nerves / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Neoplasm Invasiveness. Soft Tissue Neoplasms / mortality. Soft Tissue Neoplasms / pathology

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  • (PMID = 20526173.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 79
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94. Ritchie DA, Aniq H, Davies AM, Mangham DC, Helliwell TR: Hibernoma--correlation of histopathology and magnetic-resonance-imaging features in 10 cases. Skeletal Radiol; 2006 Aug;35(8):579-89
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  • OBJECTIVE, DESIGN AND PATIENTS: Hibernoma is an uncommon, slow-growing, benign soft-tissue tumour resembling brown adipose tissue.
  • [MeSH-major] Magnetic Resonance Imaging. Neoplasms, Adipose Tissue / pathology

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  • (PMID = 16642344.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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95. Pichi B, Manciocco V, Marchesi P, Pellini R, Ruscito P, Vidiri A, Covello R, Spriano G: Rhabdomyoma of the parapharyngeal space presenting with dysphagia. Dysphagia; 2008 Jun;23(2):202-4
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  • Rhabdomyoma is an exceedingly rare soft tissue benign tumor of skeletal muscle origin classified into cardiac and extracardiac types based on location.
  • Adult rhabdomyomas are rare, but morphologically characteristic, benign mesenchymal tumors with mature skeletal muscle differentiation that in 90% of cases arise in the head and neck region, mainly in the mucosa of the oropharynx, nasopharynx, and larynx, from the branchial musculature of third and fourth branchial arches.
  • [MeSH-major] Deglutition Disorders / etiology. Oropharyngeal Neoplasms / complications. Oropharyngeal Neoplasms / pathology. Rhabdomyoma / complications. Rhabdomyoma / pathology

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  • (PMID = 17965913.001).
  • [ISSN] 0179-051X
  • [Journal-full-title] Dysphagia
  • [ISO-abbreviation] Dysphagia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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96. Matsumura T, Yamaguchi T, Tochigi N, Wada T, Yamashita T, Hasegawa T: Angiomatoid fibrous histiocytoma including cases with pleomorphic features analysed by fluorescence in situ hybridisation. J Clin Pathol; 2010 Feb;63(2):124-8
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  • BACKGROUND: Angiomatoid fibrous histiocytoma (AFH) is a rare soft-tissue tumour of uncertain differentiation and low metastatic potential.
  • METHODS: Tumour samples from 10 patients were subjected to clinicopathological and immunohistochemical analysis and dual-colour fluorescence in situ hybridisation for EWSR1 and FUS with split-signal probes.
  • [MeSH-major] Histiocytoma, Benign Fibrous / genetics. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Adult. Calmodulin-Binding Proteins / genetics. Child. Child, Preschool. Female. Follow-Up Studies. Gene Rearrangement. Humans. In Situ Hybridization, Fluorescence / methods. Lung Neoplasms / secondary. Male. Middle Aged. Neoplasm Proteins / genetics. Neoplasm Recurrence, Local / genetics. RNA-Binding Protein FUS / genetics. RNA-Binding Proteins / genetics. Young Adult

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  • (PMID = 20154033.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Calmodulin-Binding Proteins; 0 / EWSR1 protein, human; 0 / Neoplasm Proteins; 0 / RNA-Binding Protein FUS; 0 / RNA-Binding Proteins
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97. Goh BK, Chow PK, Kesavan S, Yap WM, Wong WK: Outcome after surgical treatment of suspected gastrointestinal stromal tumors involving the duodenum: is limited resection appropriate? J Surg Oncol; 2008 Apr 1;97(5):388-91
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  • INTRODUCTION: Present surgical opinion is divided regarding the optimal method for the treatment of duodenal gastrointestinal stromal tumor (GIST) with some supporting the selective use of limited resection (LR) versus others who prefer pancreaticoduodenectomy (PD).
  • RESULTS: There were 15 GISTs, 1 leiomyosarcoma and 6 other non-GIST benign submucosal tumors.
  • Comparison between GIST and other benign tumors demonstrated that size was the only statistically significant distinguishing factor [8.5 (range, 2.5-18.0) vs. 2.5 (range, 1.5-8.0) cm, P = 0.014].
  • CONCLUSION: Benign non-GIST tumors may be distinguished from duodenal GIST as they are smaller in size.
  • [MeSH-major] Digestive System Surgical Procedures. Duodenal Neoplasms / surgery. Gastrointestinal Stromal Tumors / surgery. Outcome Assessment (Health Care)
  • [MeSH-minor] Adult. Aged. Cohort Studies. Female. Follow-Up Studies. Humans. Length of Stay. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasms, Connective and Soft Tissue / mortality. Neoplasms, Connective and Soft Tissue / pathology. Neoplasms, Connective and Soft Tissue / surgery. Paraganglioma / mortality. Paraganglioma / pathology. Paraganglioma / surgery. Retrospective Studies. Time Factors

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  • [Copyright] (Copyright) 2008 Wiley-Liss, Inc.
  • (PMID = 18163461.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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98. Bandyopadhyay S, Basturk O, Coban I, Thirabanjasak D, Liang H, Altinel D, Adsay NV: Isolated solitary ducts (naked ducts) in adipose tissue: a specific but underappreciated finding of pancreatic adenocarcinoma and one of the potential reasons of understaging and high recurrence rate. Am J Surg Pathol; 2009 Mar;33(3):425-9
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  • [Title] Isolated solitary ducts (naked ducts) in adipose tissue: a specific but underappreciated finding of pancreatic adenocarcinoma and one of the potential reasons of understaging and high recurrence rate.
  • The glandular units of invasive carcinoma are often well formed with well-polarized cells, appearing deceptively benign.
  • We recently noted isolated solitary ductal units (ISDs) in adipose tissue to be a reliable indicator of adenocarcinoma.
  • ISD was defined as a solitary gland lying individually in adipose tissue, either directly abutting adipocytes or separated from them by only a thin rim of fibromuscular tissue.
  • ISDs were often located in histologic sections taken for the evaluation of the retroperitoneal margin and pancreatic-free surfaces where adipose tissue is more abundant.
  • In conclusion, ISD lying in adipose tissue unaccompanied by other elements, present in 47.6% of pancreatic resections when peripancreatic soft tissues away from the tumor are sampled, is a very specific finding for carcinoma that may be instrumental in the diagnosis and staging of carcinoma as well as margin evaluation.
  • [MeSH-major] Adipose Tissue / pathology. Carcinoma, Pancreatic Ductal / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Pancreatitis / pathology

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  • (PMID = 19092633.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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99. Liu ZJ, Zhao Q, Zhang LJ: Extraskeletal osteochondroma near the hip: a pediatric case. J Pediatr Orthop B; 2010 Nov;19(6):524-8
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  • Extraskeletal osteochondroma near the hip is rare and its pathological diagnosis is based on radiological and histopathological examination.
  • It is vital that such a diagnosis be considered when a discrete, ossified mass is localized in soft tissues, even at atypical sites.
  • Differential diagnoses include myositis ossificans, a lipomatous lesion, a pseudomalignant osseous tumour, an ossifying fibromyxoid tumour, an extraskeletal chondroma with endochondral ossification, synovial (osteo) chondromatosis, tumoural calcinosis, a synovial sarcoma and an extraskeletal osteosarcoma.
  • Clinical awareness of this benign entity is important as no malignant transformation or metastasis has been reported.
  • [MeSH-major] Osteochondroma / pathology. Osteochondroma / surgery. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Biopsy, Needle. Child. Follow-Up Studies. Hip. Humans. Immunohistochemistry. Lumbosacral Region. Male. Neoplasm Staging. Time Factors. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20802344.001).
  • [ISSN] 1473-5865
  • [Journal-full-title] Journal of pediatric orthopedics. Part B
  • [ISO-abbreviation] J Pediatr Orthop B
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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100. Cranshaw IM, Gikas PD, Fisher C, Thway K, Thomas JM, Hayes AJ: Clinical outcomes of extra-thoracic solitary fibrous tumours. Eur J Surg Oncol; 2009 Sep;35(9):994-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Extra-thoracic solitary fibrous tumours (ESFTs) have traditionally been regarded as indolent neoplasms similar to their intra-thoracic counterparts.
  • PATIENTS/METHODS: All patients with a histopathological diagnosis of solitary fibrous tumour (SFT) who presented to the Royal Marsden Hospital between 1998 and 2006 were reviewed.
  • Locoregional recurrent disease was more common in those with malignant histopathological findings compared to those with benign histopathology (6/18 vs 0/15 p 0.021).
  • The presence of malignant histopathology was the only factor to affect survival with no benign cases dying of disease and malignant cases having a median survival of 59 months (p 0.003).
  • Those tumours with atypical or malignant features on histological examination have poor prognosis and should be managed and followed up in the same manner as other high-grade soft tissue tumours.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. London. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 19345055.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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