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1. Kravtsov VG, Zaĭrat'iants OV: [Clinical and morphological characteristics of gastrointestinal stromal tumors]. Arkh Patol; 2007 Sep-Oct;69(5):54-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • GIST are stromal tumors and the gastrointestinal tract (GIT) and some other organs of spindle-cell or epithelioid-cell structure expressing CD117 (C-kit, KIT), as well as those at different rates and in different combinations, CD34, smooth muscle and/or neurogenic differentiation antigens.
  • There are opinions that all such neoplasms are potentially malignany and small-sized GISTs are benign and have the minimum mitotic activity.
  • [MeSH-minor] Antigens, CD34 / biosynthesis. Antigens, CD34 / genetics. Apoptosis / genetics. Enzyme Activation / genetics. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Gene Expression Regulation, Neoplastic / genetics. Humans. Liver Neoplasms / drug therapy. Liver Neoplasms / genetics. Liver Neoplasms / metabolism. Liver Neoplasms / pathology. Liver Neoplasms / secondary. Melanoma / genetics. Melanoma / metabolism. Melanoma / pathology. Mitosis / genetics. Mutation. Myocytes, Smooth Muscle / metabolism. Myocytes, Smooth Muscle / pathology. Neoplasm Metastasis. Neoplastic Stem Cells / metabolism. Neoplastic Stem Cells / pathology. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / genetics. Peritoneal Neoplasms / pathology. Peritoneal Neoplasms / secondary. Sarcoma / drug therapy. Sarcoma / genetics. Sarcoma / metabolism. Sarcoma / pathology

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  • (PMID = 18074824.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Antigens, CD34; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Number-of-references] 44
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2. Gleason BC, Fletcher CD: Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential. Am J Surg Pathol; 2008 Mar;32(3):354-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential.
  • Benign fibrous histiocytoma (FH) is one of the most common mesenchymal neoplasms of the skin.
  • Deep benign FH is an uncommon and poorly recognized clinical subtype that arises in subcutaneous or deep soft tissue.
  • Immunohistochemistry revealed expression of CD34 in 20/50 cases (40%), smooth muscle actin in 15/40 (38%), and focal desmin in 1/12 (8%).
  • Of the 37 patients for whom clinical follow-up was available (median, 40 mo), 8 (22%) had a local recurrence; in all 8 cases, the tumor had been marginally or incompletely excised.
  • The metastasizing tumors were large (6 and 9 cm) and 1 had tumor necrosis but they were otherwise histologically identical to the nonmetastasizing lesions.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Neoplasm Metastasis / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Actins / analysis. Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD34 / analysis. Child. Desmin / analysis. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mitosis. Necrosis. Neoplasm Recurrence, Local

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  • (PMID = 18300816.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD34; 0 / Desmin
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3. Bilyeu SP, Bilyeu JD, Parthasarathy R: Intravenous lipoleiomyomatosis. Clin Imaging; 2006 Sep-Oct;30(5):361-4
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  • Intravenous lipoleiomyomatosis (LPL) is a rare benign tumor composed of fat and smooth muscle.
  • [MeSH-minor] Female. Heart Atria / pathology. Heart Atria / surgery. Humans. Magnetic Resonance Imaging. Middle Aged. Neoplasm Invasiveness. Pulmonary Artery / pathology. Pulmonary Artery / surgery. Tomography, X-Ray Computed

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  • (PMID = 16919562.001).
  • [ISSN] 0899-7071
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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4. Wachter DL, Büttner MJ, Grimm K, Hartmann A, Agaimy A: Leiomyoma of the gallbladder: a case report with review of the literature and discussion of the differential diagnosis. J Clin Pathol; 2010 Feb;63(2):177-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • To our knowledge, only a few patients with multiple Epstein-Barr virus (EBV)-associated smooth muscle tumours of the gallbladder in the setting of immunodeficiency have been reported in the English literature, but no single case of conventional leiomyoma has been well documented to date.
  • Histology and immunohistochemistry were consistent with a benign smooth muscle neoplasm that is very similar to conventional uterine leiomyoma.

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  • (PMID = 20154041.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 10
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5. O'Neill CJ, McBride HA, Connolly LE, McCluggage WG: Uterine leiomyosarcomas are characterized by high p16, p53 and MIB1 expression in comparison with usual leiomyomas, leiomyoma variants and smooth muscle tumours of uncertain malignant potential. Histopathology; 2007 Jun;50(7):851-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Uterine leiomyosarcomas are characterized by high p16, p53 and MIB1 expression in comparison with usual leiomyomas, leiomyoma variants and smooth muscle tumours of uncertain malignant potential.
  • In this study, p16 immunohistochemical expression was assessed in a variety of uterine smooth muscle tumours, including usual leiomyomas, leiomyoma variants, smooth muscle tumours of uncertain malignant potential (STUMPs) and leiomyosarcomas.
  • The aim was to ascertain whether there are differences in p16 expression between these groups and whether p16 is of potential value in the assessment of problematic uterine smooth muscle neoplasms. p16 expression was also compared with that of p53 and MIB1.
  • CONCLUSIONS: p16 is overexpressed in uterine leiomyosarcomas compared with leiomyomas, benign leiomyoma variants and STUMPs, suggesting that p16 may be implicated in the pathogenesis of malignant uterine smooth muscle neoplasms. p16, in combination with p53 and MIB1, may be of value as an adjunct to morphological examination in the assessment of problematic uterine smooth muscle tumours, although further large-scale studies with follow-up are necessary to confirm this.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Leiomyoma / metabolism. Leiomyosarcoma / metabolism. Smooth Muscle Tumor / metabolism. Tumor Suppressor Protein p53 / metabolism. Ubiquitin-Protein Ligases / metabolism. Uterine Neoplasms / metabolism
  • [MeSH-minor] Cell Count. Female. Humans. Immunohistochemistry. Neoplasm Proteins / metabolism

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  • (PMID = 17543074.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Neoplasm Proteins; 0 / Tumor Suppressor Protein p53; EC 6.3.2.19 / MIB1 ligase, human; EC 6.3.2.19 / Ubiquitin-Protein Ligases
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6. Lin YC, Wei LH, Shun CT, Cheng AL, Hsu CH: Disseminated peritoneal leiomyomatosis responds to systemic chemotherapy. Oncology; 2009;76(1):55-8
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  • Leiomyomatosis peritonealis disseminata (LPD) is a rare disease entity characterized by multiple peritoneal tumors composed of benign but proliferative smooth muscle cells.
  • Objective tumor response was achieved and sustained for 1 year.
  • [MeSH-minor] Female. Humans. Middle Aged. Mitosis. Neoplasm Recurrence, Local. Uterine Neoplasms / surgery

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  • (PMID = 19039249.001).
  • [ISSN] 1423-0232
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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7. Zimmermann A, von der Brelie C, Berger B, Kappeler A, Candinas D: Primary perivascular epithelioid cell tumor of the liver not related to hepatic ligaments: hepatic PEComa as an emerging entity. Histol Histopathol; 2008 10;23(10):1185-93
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  • [Title] Primary perivascular epithelioid cell tumor of the liver not related to hepatic ligaments: hepatic PEComa as an emerging entity.
  • Primary perivascular epithelioid cell tumor (PEComa) of the liver is a very rare example of an emerging family of hepatic PEC tumors.
  • We report the case of a large but benign hepatic PEComa in a 53-year-old man without signs of tuberous sclerosis.
  • In contrast to recently described PEC-derived liver tumors in children and young adults, this neoplasm was not related to the hepatic ligaments but had developed deeply within the liver substance.
  • The neoplastic cells displayed the complete phenotype typical for PEComas, i.e. reactivity for several melanoma markers and for smooth muscle actin.
  • The unique relationship of myoid tumor cells to the adventitia of blood vessels prompted us, in comparison with published findings obtained with angiomyolipomas, to comment on the possible origin of the still enigmatic perivascular epithelioid cells.

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  • (PMID = 18712670.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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8. Brown L: Pathology of uterine malignancies. Clin Oncol (R Coll Radiol); 2008 Aug;20(6):433-47
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  • Some types of mixed epithelial and stromal neoplasm are described and contrasted with carcinosarcoma.
  • The concept of stromal sarcoma and high-grade uterine sarcoma is described and an outline of malignant smooth muscle tumours of the uterus includes a description of smooth muscle tumours of uncertain malignant potential and worrying benign smooth muscle lesions.

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  • (PMID = 18499412.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 233
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9. Holland KE, Galbraith SS: Generalized congenital smooth muscle hamartoma presenting with hypertrichosis, excess skin folds, and follicular dimpling. Pediatr Dermatol; 2008 Mar-Apr;25(2):236-9
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  • [Title] Generalized congenital smooth muscle hamartoma presenting with hypertrichosis, excess skin folds, and follicular dimpling.
  • We describe an interesting patient with a diffuse smooth muscle hamartoma who presented with hypertrichosis, increased skin folds, and follicular dimpling.
  • While smooth muscle hamartoma classically presents as a small hairy, skin-colored to hyperpigmented patch or plaque, rare presentations with diffuse involvement or follicular papules have been described.
  • We present our patient and review the literature to highlight the diverse and under recognized manifestations of this benign neoplasm.
  • [MeSH-major] Hamartoma / congenital. Hamartoma / diagnosis. Muscle, Smooth / pathology. Skin Neoplasms / congenital. Skin Neoplasms / diagnosis

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  • (PMID = 18429788.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Kourda J, Ismail O, Smati BH, Ayadi A, Kilani T, El Mezni F: Benign myoepithelioma of the lung - a case report and review of the literature. Cases J; 2010;3(1):25
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  • [Title] Benign myoepithelioma of the lung - a case report and review of the literature.
  • INTRODUCTION: Benign myoepithelioma is extremely rare in the lung, to the best of our knowledge; only five cases have been reported in the literature.
  • No mitotic activity or necrosis was seen in the tumor.
  • Immuhistochemically, the tumor cells positive for smooth muscle actin, vimentine, and S100 protein.
  • The diagnosis of benign myoepithelioma of the lung is so confirmed.
  • CONCLUSION: Benign myoepithelioma is a rare pulmonary neoplasm distinct from pleomorphic adenoma, which should be considered in the differential diagnosis of lung nodules.

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  • [Cites] Radiology. 2005 Nov;237(2):395-400 [16244247.001]
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  • (PMID = 20180958.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2828429
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11. Suh I, Shibru D, Eisenhofer G, Pacak K, Duh QY, Clark OH, Kebebew E: Candidate genes associated with malignant pheochromocytomas by genome-wide expression profiling. Ann Surg; 2009 Dec;250(6):983-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To improve our understanding of the molecular mechanisms involved in malignant pheochromocytoma by examining differences in the gene expression profile between benign and malignant tumors.
  • There are also no reliable and uniformly accepted histopathologic criteria to distinguish benign from malignant pheochromocytoma.
  • METHODS: We performed genome-wide expression profiling of 58 pheochromocytomas (29 benign and sporadic, 16 benign and hereditary, 13 malignant) with technical and biologic replication.
  • Supervised cluster analysis showed almost completely separate clustering between benign and malignant tumors.
  • The differentially expressed genes with known function belonged to 8 biologic process categories; signal transduction, transcription, protein transport, protein synthesis, smooth muscle contraction, ion transport, chemotaxis, and electron transport.
  • Ten differentially expressed genes had high diagnostic accuracy, and 5 of these genes (CFC1, FAM62B, HOMER1, LRRN3, TBX3, ADAMTS) in combination had an area under the receiver operating characteristic (ROC) curve of 0.96 for distinguishing benign versus malignant tumors.
  • CONCLUSIONS: Differentially expressed genes between benign and malignant pheochromocytomas distinguish between these tumors with high diagnostic accuracy.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Gene Expression Regulation, Neoplastic. Genes, Neoplasm / genetics. Genetic Association Studies / methods. Pheochromocytoma / genetics. RNA, Neoplasm / genetics

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  • (PMID = 19661783.001).
  • [ISSN] 1528-1140
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Neoplasm
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12. Gomez-Moyano E, Vera-Casaño A, Martinez-Garcia S, Sanz-Trelles A, Crespo-Erchiga V: Two cases of dermatomyofibroma (plaque-like dermal fibromatosis). Int J Dermatol; 2010 Aug;49(8):914-7
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  • BACKGROUND: Dermatomyofibroma is a rare but distinct benign cutaneous mesenchymal neoplasm of fibroblastic/myofibroblastic differentiation.
  • In both cases the spindle cells stained positive for smooth muscle actin and the elastic fibers were increased and fragmented.
  • CONCLUSION: Dermatologists and pediatricians should be aware of this benign entity in order to avoid unnecessary treatment.
  • [MeSH-major] Dermis / pathology. Fibroblasts / pathology. Histiocytoma, Benign Fibrous / diagnosis. Muscle, Smooth / pathology. Skin Neoplasms / diagnosis

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  • [Copyright] © 2010 The International Society of Dermatology.
  • (PMID = 21174375.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Pitukkijronnakorn S, Leelachaikul P, Chittacharoen A: Labial leiomyoma: a case report. J Med Assoc Thai; 2005 Jan;88(1):118-9
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  • Leiomyoma is normally a benign smooth muscle tumor and behaves as a hormone sensitive tumor Leiomyomas develop during the reproductive age and regress after menopause.

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  • (PMID = 15960230.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
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14. Liegl B, Hornick JL, Fletcher CD: Primary cutaneous PEComa: distinctive clear cell lesions of skin. Am J Surg Pathol; 2008 Apr;32(4):608-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tumor size ranged from 0.7 to 2 cm (median size, 1.5 cm).
  • Tumor cells had clear, palely eosinophilic or granular cytoplasm.
  • Multinucleate tumor giant cells were observed in 3 cases.
  • In cases where HMB-45 was positive in fewer than 5% of tumor cells (5/10), microphthalmia transcription factor was positive in the majority of the tumor cell nuclei.
  • Desmin positivity was observed in 5 and smooth muscle actin in 1 case, respectively.
  • The other muscle markers (caldesmon, calponin) and also pan-keratin and epithelial membrane antigen were negative.
  • Primary cutaneous PEComas are rare and thus far apparently benign cutaneous tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Actins / analysis. Adolescent. Adult. Aged. Aged, 80 and over. Antigens, Neoplasm / analysis. Calcium-Binding Proteins / analysis. Calmodulin-Binding Proteins / analysis. Dermis / pathology. Desmin / analysis. Diagnosis, Differential. Female. Giant Cells / pathology. Humans. Immunohistochemistry. Keratins / analysis. MART-1 Antigen. Male. Melanoma-Specific Antigens. Microfilament Proteins / analysis. Microphthalmia-Associated Transcription Factor / analysis. Middle Aged. Mitotic Index. Mucin-1 / analysis. Neoplasm Invasiveness. Neoplasm Proteins / analysis. Subcutaneous Fat / pathology

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  • [CommentIn] Am J Dermatopathol. 2016 Feb;38(2):165-6 [26825164.001]
  • (PMID = 18277881.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Calcium-Binding Proteins; 0 / Calmodulin-Binding Proteins; 0 / Desmin; 0 / MART-1 Antigen; 0 / MITF protein, human; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Microfilament Proteins; 0 / Microphthalmia-Associated Transcription Factor; 0 / Mucin-1; 0 / Neoplasm Proteins; 0 / calponin; 68238-35-7 / Keratins
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15. Starost MF: Adenomyofibroma of the fimbria in a cynomolgus monkey (Macaca fascicularis). J Vet Diagn Invest; 2009 Nov;21(6):892-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The interstitium contained a proliferation of smooth muscle stromal cells admixed with varying amounts of collagen.
  • This benign neoplasm should be considered as a differential diagnosis for masses arising from the fallopian tube in old-world macaques.

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  • (PMID = 19901298.001).
  • [ISSN] 1040-6387
  • [Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • [ISO-abbreviation] J. Vet. Diagn. Invest.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
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16. Metta H, Corti M, Redini L, Dure R, Campitelli AM, Narbaitz M: Endobronchial leiomyoma: an unusual non-defining neoplasm in a patient with AIDS. Rev Inst Med Trop Sao Paulo; 2009 Jan-Feb;51(1):53-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endobronchial leiomyoma: an unusual non-defining neoplasm in a patient with AIDS.
  • Smooth muscle neoplasms are more frequent in human immunodeficiency infected children than in HIV seropositive adults.
  • Endobronchial leiomyoma is a rare benign tumor in HIV infected adult patients.
  • Our report suggests that smooth muscle tumors as leiomyoma should be included in the differential diagnosis of endobronchial masses in AIDS patients.

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  • (PMID = 19229392.001).
  • [ISSN] 1678-9946
  • [Journal-full-title] Revista do Instituto de Medicina Tropical de São Paulo
  • [ISO-abbreviation] Rev. Inst. Med. Trop. Sao Paulo
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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17. Kiss S, Gragoudas ES, Dryja TP, Jakobiec FA: Response of choroidal leiomyoma to treatment with proton beam radiation. Retin Cases Brief Rep; 2010;4(2):168-73
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  • PURPOSE: Uveal leiomyoma is a rare, benign smooth muscle neoplasm usually diagnosed only after local resection or enucleation.
  • The neoplasm was treated with a total of 70 cobalt gray equivalents of external proton beam radiation in 5 fractions over 7 days.
  • Biannual follow-up examinations over 3 years showed a funduscopically and ultrasonographically regressing tumor.
  • Microscopic and immunohistochemical examination of the mass revealed a choroidal neoplasm expressing smooth muscle antigens consistent with a uveal leiomyoma.

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  • (PMID = 25390394.001).
  • [ISSN] 1935-1089
  • [Journal-full-title] Retinal cases & brief reports
  • [ISO-abbreviation] Retin Cases Brief Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Zhang P, Zhang C, Hao J, Sung CJ, Quddus MR, Steinhoff MM, Lawrence WD: Use of X-chromosome inactivation pattern to determine the clonal origins of uterine leiomyoma and leiomyosarcoma. Hum Pathol; 2006 Oct;37(10):1350-6
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  • Uterine leiomyomas (LMs) and leiomyosarcomas (LMSs), both of smooth muscle origin, sometimes coexist in the same uterus.
  • In 2 of the 3 patients, the tumor also exhibited a morphological transition between benign cells in LM and malignant cells in LMS, supporting the possibility of transformation from LM to LMS.
  • [MeSH-minor] Adult. Clone Cells. DNA, Neoplasm / analysis. Female. Humans. Middle Aged. Polymerase Chain Reaction. Receptors, Androgen / genetics


19. Seyama K, Kumasaka T, Kurihara M, Mitani K, Sato T: Lymphangioleiomyomatosis: a disease involving the lymphatic system. Lymphat Res Biol; 2010 Mar;8(1):21-31
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  • BACKGROUND: Lymphangioleiomyomatosis (LAM) is a rare neoplastic disease in which abnormal smooth muscle-like cells (LAM cells) proliferate in the lungs and along the axial lymphatic systems, including the lymph nodes and thoracic ducts.
  • LAM cells are transformed due to loss-of-function type mutations of either the TSC1 or TSC2 tumor suppressor genes.
  • The pathological features include the proliferation of benign-looking LAM cells and the existence of abundant lymphatic vessels that are associated with clinical conditions such as chyle leakage.
  • CONCLUSION: LAM appears to be a disease involving a dysfunction of the lymphatic system and a fascinating model of tumor dissemination that is exclusively lymphangitic.
  • [MeSH-major] Lymphangioleiomyomatosis / metabolism. Lymphatic System / metabolism. Neoplasm Proteins / metabolism


20. Esmaeilzadeh M, Tavakolli A, Safaei A: Recurrent intracardiac leiomyomatosis. Can J Cardiol; 2007 Nov;23(13):1085-6
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  • An intravenous leiomyoma, a histologically benign smooth muscle tumour, arises from either a uterine myoma or the walls of a uterine vessel, with extension into veins.
  • [MeSH-major] Heart Neoplasms / secondary. Leiomyomatosis / diagnostic imaging. Smooth Muscle Tumor / diagnostic imaging. Uterine Neoplasms / diagnostic imaging
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Recurrence, Local. Ultrasonography

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  • [Cites] Am J Med. 1980 Sep;69(3):471-5 [7416191.001]
  • [Cites] N Engl J Med. 1980 Oct 30;303(18):1043-4 [7421892.001]
  • [Cites] Cardiovasc Surg. 1995 Dec;3(6):693-6 [8745195.001]
  • [Cites] Pathol Annu. 1988;23 Pt 2:153-83 [3060811.001]
  • [Cites] Am Heart J. 1987 Jan;113(1):171-8 [3541555.001]
  • (PMID = 17985013.001).
  • [ISSN] 0828-282X
  • [Journal-full-title] The Canadian journal of cardiology
  • [ISO-abbreviation] Can J Cardiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2651934
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21. Hakverdi S, Dolapçioğlu K, Güngören A, Yaldiz M, Hakverdi AU: Multiple uterine angioleiomyomas mimicking an ovarian neoplasm: a case report. Eur J Gynaecol Oncol; 2009;30(5):592-4
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  • [Title] Multiple uterine angioleiomyomas mimicking an ovarian neoplasm: a case report.
  • Angioleiomyoma is a rare benign neoplasm that originates from smooth muscle cells and contains thick-walled blood vessels.
  • On pathologic examination of the specimen, the tumor was diagnosed as an angioleiomyoma.
  • Here, we present a case of giant-multiple uterine angioleiomyomas mimicking an ovarian neoplasm.

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  • (PMID = 19899426.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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22. Bello IO, Alanen K, Slootweg PJ, Salo T: Alpha-smooth muscle actin within epithelial islands is predictive of ameloblastic carcinoma. Oral Oncol; 2009 Sep;45(9):760-5
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  • [Title] Alpha-smooth muscle actin within epithelial islands is predictive of ameloblastic carcinoma.
  • Ameloblastoma is the most common clinically significant odontogenic tumor.
  • It is considered benign but locally invasive and associated with variable clinico-pathological behavior.
  • Ameloblastic carcinoma is a malignant tumor having features of ameloblastoma in addition to cytologic atypia with or without metastasis.
  • We examined immunohistochemically Ki-67, epithelial membrane antigen (EMA), alpha-smooth muscle actin (alpha-SMA), calponin, p63 and DNA content using image (ICM) and flow cytometry (FCM) in three ameloblastic carcinomas and up to 18 SAs.
  • [MeSH-major] Ameloblastoma / pathology. Carcinoma / pathology. Mandibular Neoplasms / pathology. Maxillary Neoplasms / pathology. Neoplasm Proteins / metabolism
  • [MeSH-minor] Actins / metabolism. Calcium-Binding Proteins / metabolism. Female. Finland. Flow Cytometry. Humans. Image Cytometry. Ki-67 Antigen / metabolism. Male. Membrane Proteins / metabolism. Microfilament Proteins / metabolism. Mucin-1 / metabolism. Muscle, Smooth / metabolism. Muscle, Smooth / pathology. Netherlands. Retrospective Studies

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  • (PMID = 19150605.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Actins; 0 / CKAP4 protein, human; 0 / Calcium-Binding Proteins; 0 / Ki-67 Antigen; 0 / Membrane Proteins; 0 / Microfilament Proteins; 0 / Mucin-1; 0 / Neoplasm Proteins; 0 / calponin
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23. Kusumi T, Minakawa M, Fukui K, Saito S, Ohashi M, Sato F, Fukuda I, Kijima H: Cardiac tumor comprising two components including typical myxoma and atypical hypercellularity suggesting a malignant change. Cardiovasc Pathol; 2009 Nov-Dec;18(6):369-74
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  • [Title] Cardiac tumor comprising two components including typical myxoma and atypical hypercellularity suggesting a malignant change.
  • BACKGROUND: Cardiac myxoma is a benign neoplasm and is not considered to carry a risk of malignant transformation.
  • We describe a case of a cardiac tumor comprising typical myxoma and atypical cellular parts.
  • METHODS AND RESULTS: A 72-year-old woman was found to have a tumor in the left atrial chamber after undergoing echocardiographic investigation and so she underwent tumor excision surgery.
  • The excised tumor was composed of two components with different features with a smooth transition from one type to the other.
  • The apex of the tumor showed a gelatinous and villous appearance on gross examination, and histological examination revealed that the tumor cells had small oval nuclei and eosinophilic cytoplasm and were arranged in cords and vasoformative structures in the myxoid matrix.
  • The base of the tumor appeared as a solid mass on gross examination with hypercellular proliferation of spindle-shaped tumor cells and intersecting fascicles observed histologically.
  • On immunohistochemistry, the tumor cells were found to be positive for alpha-smooth muscle actin, calretinin, and CD34, and this immunoreactivity was decreased at the tip.
  • CONCLUSIONS: We diagnosed this tumor as cardiac myxoma with an atypical hypercellular component suggesting a malignant change.

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  • (PMID = 18619858.001).
  • [ISSN] 1879-1336
  • [Journal-full-title] Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
  • [ISO-abbreviation] Cardiovasc. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Romeo S, Eyden B, Prins FA, Briaire-de Bruijn IH, Taminiau AH, Hogendoorn PC: TGF-beta1 drives partial myofibroblastic differentiation in chondromyxoid fibroma of bone. J Pathol; 2006 Jan;208(1):26-34
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  • Chondromyxoid fibroma (CMF) is a rare benign cartilaginous bone tumour with a lobular architecture containing stellate and myofibroblast-like spindle cells.
  • The aim of this study was to investigate the presence, spatial distribution, and extent of myoid differentiation in CMF and to evaluate a possible causative role for TGF-beta1 signalling, which is known to promote smooth muscle actin (SMA) expression.
  • Twenty cases were studied for immunoreactivity for muscle-specific actin (MSA), SMA, desmin, h-caldesmon, calponin, TGF-beta1, and plasminogen activator inhibitor type 1 (PAI-1).
  • [MeSH-minor] Actins / immunology. Adolescent. Adult. Calcium-Binding Proteins / immunology. Calmodulin-Binding Proteins / immunology. Cell Transformation, Neoplastic. Child. Chondrocytes / pathology. Chondrocytes / ultrastructure. Desmin / immunology. Female. Fibroblasts / pathology. Fibroblasts / ultrastructure. Fibronectins / genetics. Fibronectins / immunology. Genes, Neoplasm / genetics. Humans. Immunohistochemistry / methods. Male. Microfilament Proteins. Microscopy, Electron / methods. Microscopy, Immunoelectron / methods. Middle Aged. Muscle Proteins / immunology. Muscle, Smooth / immunology. Neoplasm Proteins / immunology. Plasminogen Activator Inhibitor 1 / genetics. Plasminogen Activator Inhibitor 1 / immunology. Reverse Transcriptase Polymerase Chain Reaction / methods. Signal Transduction / physiology. Transforming Growth Factor beta1

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  • [Copyright] Copyright 2005 Pathological Society of Great Britain and Ireland.
  • (PMID = 16278817.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Actins; 0 / Calcium-Binding Proteins; 0 / Calmodulin-Binding Proteins; 0 / Desmin; 0 / Fibronectins; 0 / Microfilament Proteins; 0 / Muscle Proteins; 0 / Neoplasm Proteins; 0 / Plasminogen Activator Inhibitor 1; 0 / TGFB1 protein, human; 0 / Transforming Growth Factor beta; 0 / Transforming Growth Factor beta1; 0 / calponin
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25. Gaitan Cepeda LA, Quezada Rivera D, Tenorio Rocha F, Leyva Huerta ER, Mendez Sánchez ER: Vascular leiomyoma of the oral cavity. Clinical, histopathological and immunohistochemical characteristics. Presentation of five cases and review of the literature. Med Oral Patol Oral Cir Bucal; 2008 Aug;13(8):E483-8
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  • Leiomyoma, a benign neoplasia arising from smooth muscle is an uncommon neoplasia of the oral cavity.
  • The immunocharacteristics of VLOC neoplastic cells were: alpha smooth muscle (+); vimentin (+), desmin (+), CD34 (-) and S-100 protein (-).
  • Differential diagnosis of VLOC with fusocellular neoplasm is discussed.

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  • (PMID = 18667980.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 23
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26. Sulentić P, Abdović S, Filipović J, Tomas D: Pedunculated myolipoma incidentally found in hernial sac: a case report. Acta Clin Croat; 2009 Jun;48(2):171-4
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  • A case of a very rare adipocytic tumor found during corrective surgery for incisional abdominal hernia is presented.
  • During surgery of incisional hernia, a part of small intestine along with a pedunculated tumor was found in hernial sac.
  • The tumor was attached to the medial intra-abdominal peritoneum.
  • On examination, the tumor presented as a totally encapsulated dimorphic benign neoplasm composed of mature adipocytes and well-differentiated smooth muscle cells.
  • Tumor cells were negative for HMB45, estrogen and progesterone.
  • This tumor commonly presents as a large quiescent mass in retroperitoneum in adult females and to our knowledge this is the first report of myolipoma in hernial sac.
  • Characteristic findings, differential diagnosis, prognosis and the possible origin of such a neoplasm are discussed.

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  • (PMID = 19928417.001).
  • [ISSN] 0353-9466
  • [Journal-full-title] Acta clinica Croatica
  • [ISO-abbreviation] Acta Clin Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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27. Jeda A, Karoń J, Rak M: [The nodule of the small intestine--a rare case of benign metastasizing leiomyoma]. Ginekol Pol; 2009 Sep;80(9):716-9
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  • [Title] [The nodule of the small intestine--a rare case of benign metastasizing leiomyoma].
  • [Transliterated title] Guzek jelita cienkiego--rzadki przypadek mieśniaka przerzutowego (benign metastasizing leiomyoma).
  • The diagnosis of benign metastasizing leiomyoma BML is a casuic case.
  • The term is used to describe a entity of neoplasms characterized by a proliferation of smooth muscle cells with low mitotic index, usually located outside female genital organs.
  • In the world literature there are reports of benign metastasizing leiomyomas in the lungs, skull base and spine, the lymph nodes of the small pelvis and the heart.
  • [MeSH-minor] Aged. Female. Humans. Hysterectomy. Intestine, Small. Neoplasm Metastasis. Treatment Outcome

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  • (PMID = 19886249.001).
  • [ISSN] 0017-0011
  • [Journal-full-title] Ginekologia polska
  • [ISO-abbreviation] Ginekol. Pol.
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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28. Tamas EF, Epstein JI: Detection of residual tumor cells in bladder biopsy specimens: pitfalls in the interpretation of cytokeratin stains. Am J Surg Pathol; 2007 Mar;31(3):390-7
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  • [Title] Detection of residual tumor cells in bladder biopsy specimens: pitfalls in the interpretation of cytokeratin stains.
  • The detection of a few residual tumor cells in bladder specimens with prior biopsy site changes can be challenging based on histology alone.
  • We have noted several cases in which keratin stains were performed and positive cells were noted, raising the issue as to whether the cytokeratin positive cells were residual tumor cells or stromal cells.
  • Immunohistochemistry for a panel of antibodies [AE1/AE3, CAM 5.2, high molecular weight cytokeratin, smooth muscle actin (SMA), desmin, and anaplastic lymphoma kinase (ALK)] was performed on 29 cases of bladder biopsies with prior biopsy site changes.
  • Of 29 patients, 25 had a prior history of bladder tumor: 17 had invasive high-grade urothelial carcinoma (T1, 5 cases; T2, 11 cases; T3,1 case); 7 had noninvasive high-grade papillary urothelial carcinoma; 1 had noninvasive low-grade papillary urothelial carcinoma).
  • Four patients had prior benign bladder diagnoses: cystitis cystica et glandularis; polypoid cystitis; follicular cystitis; and neurogenic bladder with benign prostate hyperplasia.
  • Another 3 cases with concurrent staining for at least 1 of the keratins, SMA and desmin were consistent with smooth muscle cells on the basis of their cellular morphology.
  • When interpreting CK stains for the detection of residual tumor cells, one should pay attention to the nature of the cells and not assume all CK staining cells are residual tumor cells.
  • [MeSH-major] Carcinoma, Transitional Cell / pathology. Diagnostic Errors / prevention & control. Keratins / analysis. Neoplasm, Residual / pathology. Urinary Bladder / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Biopsy. Humans. Immunohistochemistry. Middle Aged. Neoplasm Recurrence, Local. Urothelium / chemistry. Urothelium / pathology

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  • (PMID = 17325480.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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29. Bodner-Adler B, Bartl M, Wagner G: Intravenous leiomyomatosis of the uterus with pulmonary metastases or a case with benign metastasizing leiomyoma? Anticancer Res; 2009 Feb;29(2):495-6
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  • [Title] Intravenous leiomyomatosis of the uterus with pulmonary metastases or a case with benign metastasizing leiomyoma?
  • BACKGROUND: Intravenous leiomyomatosis (IVL) is defined as an intraluminal growth of benign smooth muscle cells in either venous or lymphatic vessels outside the confines or even in the absence of leiomyomas.
  • Benign metastasizing uterine leiomyoma is defined as a histologically benign uterine smooth muscle tumor that acts in a somewhat malignant fashion and produces benign metastases.
  • CONCLUSION: Though intravenous leiomyomatosis imitates a malignant neoplasm concerning the pattern of growth and extension, and benign metastasizing leiomyoma produces benign metastases, they must be differentiated histologically from malignant tumors to prevent overtreatment.


30. Xiang H, Ding W, Liu F, Ren GP, Wang ZM, Zhu XZ: [Clinicopathologic analysis of mixed epithelial and stromal tumor of kidney and adult cystic nephroma]. Zhonghua Bing Li Xue Za Zhi; 2009 Jul;38(7):436-40
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  • [Title] [Clinicopathologic analysis of mixed epithelial and stromal tumor of kidney and adult cystic nephroma].
  • OBJECTIVE: To study the clinicopathologic features, immunophenotype and differential diagnosis of mixed epithelial and stromal tumor of kidney (MEST) and adult cystic nephroma (CN).
  • The spindle cells in MEST expressed vimentin (5/5), smooth muscle actin (3/5), desmin (4/5), CD10 (5/5), estrogen receptor (4/5) and progesterone receptor (4/5).
  • On the other hand, the spindle cells in CN were variably positive for vimentin (4/4), smooth muscle actin (4/4), desmin (1/4), estrogen receptor (3/4) and progesterone receptor (1/4).
  • CONCLUSIONS: Both MEST and CN are uncommon renal neoplasm.
  • Most of them run a benign clinical course.
  • The stromal cells in MEST show smooth muscle or myofibroblastic differentiation.

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  • (PMID = 19781188.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / ACTA2 protein, human; 0 / Actins; 0 / Desmin; 0 / Receptors, Estrogen; 0 / Vimentin
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31. Miyamoto H, Molena DA, Schoeniger LO, Haodong Xu: Solitary fibrous tumor of the pancreas: a case report. Int J Surg Pathol; 2007 Jul;15(3):311-4
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  • [Title] Solitary fibrous tumor of the pancreas: a case report.
  • Solitary fibrous tumor (SFT) is an unusual mesenchymal neoplasm that most often arises in the pleura; however, it has recently been described in a number of extrapleural sites.
  • This report describes an extremely rare case of a benign SFT arising in the pancreas.
  • An endocrine tumor was clinically suspected.
  • Microscopically, the tumor was composed of bland uniform spindle cells arranged between collagen bundles.
  • On immunohistochemical studies, these spindle cells were positive for CD34 and bcl-2 but negative for cytokeratin (AE1+AE3 and Cam5.2), smooth muscle actin, desmin, S-100, and c-kit.

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  • (PMID = 17652547.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Proto-Oncogene Proteins c-bcl-2
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32. Vujevich JJ, Goldberg LH, Kimyai-Asadi A, Law R: Recurrent nodule on the nasal columella: a good reason to re-biopsy. Int J Dermatol; 2008 Jul;47(7):728-31
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  • METHODS: Frozen sections revealed a spindle cell neoplasm.
  • Permanent section immunohistochemistry sections stained positive for vimentin and smooth muscle actin and negative for S100 and CD34, confirming the diagnosis of leiomyosarcoma.
  • RESULTS: The tumor was removed using Mohs micrographic surgery.
  • Re-biopsy of a "benign" growth may be necessary if clinicopathological correlation does not match with the clinical behavior of the tumor in question.
  • [MeSH-major] Leiomyosarcoma / pathology. Neoplasm Recurrence, Local / pathology. Neurofibroma / pathology. Skin Neoplasms / pathology

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  • (PMID = 18613884.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. Koletsa T, Karayannopoulou G, Dereklis D, Vasileiadis I, Papadimitriou CS, Hytiroglou P: Mesectodermal leiomyoma of the ciliary body: report of a case and review of the literature. Pathol Res Pract; 2009;205(2):125-30
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  • Mesectodermal leiomyoma of the ciliary body is a rare benign tumor with double (muscular and neural) differentiation.
  • This neoplasm is considered to originate from the ciliary body smooth muscle, a neural crest derivative.
  • The tumor measured 1.2cm in greatest dimension, and consisted of spindle and ovoid cells with abundant fibrillary cytoplasmic processes.
  • Immunohistochemical stains revealed positivity for smooth muscle actin, caldesmon, neuron-specific enolase, and CD56 antigen.
  • A review of the 23 cases thus far reported in the literature shows a striking predilection for women, as well as significant difficulties in differentiating this tumor from malignant melanoma on clinical grounds.
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Child. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 18930601.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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34. Perko Z, Durdov MG, Druzijanić N, Kraljević D, Juricić J: Giant perianal angiomyofibroblastoma--a case report. Coll Antropol; 2006 Mar;30(1):243-6
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  • A 45-year old female had a long history of slow growing perianal tumor at the right side of her anus.
  • Immunohistochemically, expression of smooth-muscle actin and desmin, as well as estrogen and progesterone receptor were found in the tumour cells.
  • This rare benign tumour typically involves vulvovaginal, pelvic and perinal region.
  • It is important to separate this neoplasm from locally invasive aggressive angiomyxoma and low grade fibromyxoid sarcoma, which can arise in the the same localisation.
  • [MeSH-major] Angiomyoma / pathology. Genital Neoplasms, Female / pathology. Neoplasms, Muscle Tissue / pathology

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  • (PMID = 16617606.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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35. Svec A, Velenská Z: Renal epithelioid angiomyolipoma--a close mimic of renal cell carcinoma. Report of a case and review of the literature. Pathol Res Pract; 2005;200(11-12):851-6
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  • The epithelioid variant of angiomyolipoma (EAML) is a rare tumor of unpredictable behavior that is composed of epithelioid, spindle, and giant cells and contains no or only a minimal amount of lipomatous tissue.
  • Grossly, a well-demarcated, spheroid, largely hemorrhagic tumor measuring 4.2 cm in diameter occupied the central third of the kidney.
  • Immunohistochemically, the tumor cells showed positive reactions with antibodies against HMB-45, melan A, CD-68, muscle-specific actin, and, rarely, smooth muscle actin.
  • As a sporadic renal tumor it followed a benign course in most of the reported cases.
  • [MeSH-minor] Actins / analysis. Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Antigens, Neoplasm. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Giant Cells / pathology. Humans. MART-1 Antigen. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / analysis. Treatment Outcome

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  • (PMID = 15792132.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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36. Gupta A, Chandra N, Sharma A, Husain N, Kureel SN: Renal leiomyoma in a child: a rare renal tumor. J Pediatr Surg; 2010 Sep;45(9):1900-3
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  • [Title] Renal leiomyoma in a child: a rare renal tumor.
  • Renal leiomyoma is a rare benign smooth muscle tumor of the kidney.
  • We report a case of right renal leiomyoma in a 6-year-old boy which was suspected of being a Wilms tumor.
  • Contrast-enhanced computed tomography could not differentiate leiomyoma in the kidney, and the mass was diagnosed as a Wilms tumor.
  • There may be a role for nephron sparing surgery, provided the tumor is small, and one has a strong suspicion for the lesion being benign.

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20850642.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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37. Buza N, Zekry N, Charpin C, Tavassoli FA: Myoepithelial carcinoma of the breast: a clinicopathological and immunohistochemical study of 15 diagnostically challenging cases. Virchows Arch; 2010 Sep;457(3):337-45
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  • Most often it presents with a spindle cell morphology that can mimic several benign and malignant lesions and may be misdiagnosed by the pathologist.
  • We report 15 cases of MEC, which were sent to our consultation practice: Five of them were initially diagnosed as benign.
  • The tumor size measured between 1 and 4.8 cm (mean 2.6 cm).
  • Microscopically, the tumors had infiltrative growth pattern most frequently with thin anastomosing cords of tumor cells associated with an intimately admixed reactive spindle cell stroma.
  • Immunohistochemical stains for p63, CD10, CK903, and CK5/6 reacted strongly and diffusely with the tumor cells, and mainly the reactive stroma had weak positivity for calponin, S-100, and smooth muscle actin.
  • MEC is a potentially aggressive malignant neoplasm sharing many features with metaplastic carcinomas.
  • Morphologically, it is often difficult to distinguish it from benign spindle cell proliferations.
  • [MeSH-major] Biomarkers, Tumor / analysis. Breast Neoplasms / pathology. Carcinoma / pathology


38. Hornick JL, Fletcher CD: Cellular neurothekeoma: detailed characterization in a series of 133 cases. Am J Surg Pathol; 2007 Mar;31(3):329-40
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  • Cellular neurothekeomas are distinctive benign cutaneous tumors of uncertain histogenesis.
  • Mean tumor size was 1.1 cm (range: 0.3 to 6 cm; 90% <2 cm).
  • In 30% of cases, neurothekeoma was suggested by the referring pathologist; the most common other diagnoses offered were plexiform fibrohistiocytic tumor, benign fibrous histiocytoma, and a low-grade sarcoma.
  • Histologically, most cases were poorly marginated; 33 (25%) infiltrated fat, and 10 (8%) entrapped skeletal muscle (all but 1 situated on the face).
  • All tumors were reactive for NKI-C3, 110/123 (89%) expressed neuron-specific enolase, 73/127 (57%) showed at least focal staining for smooth muscle actin, and only 1 was focally desmin positive.
  • Ten tumors recurred locally (7 situated on the face), after a mean of 18 months; tumor had been marginally excised or had involved excision margins in all cases with available information.
  • There is no good evidence that these lesions show nerve sheath differentiation and the nomenclature will likely change when the tumor cell lineage is better defined.
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Child. Child, Preschool. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Immunohistochemistry. Infant. Male. Middle Aged. Mitosis. Neoplasm Recurrence, Local. Sarcoma / diagnosis

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  • (PMID = 17325474.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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39. Chang T, Husain AN, Colby T, Taxy JB, Welch WR, Cheung OY, Early A, Travis W, Krausz T: Pneumocytic adenomyoepithelioma: a distinctive lung tumor with epithelial, myoepithelial, and pneumocytic differentiation. Am J Surg Pathol; 2007 Apr;31(4):562-8
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  • [Title] Pneumocytic adenomyoepithelioma: a distinctive lung tumor with epithelial, myoepithelial, and pneumocytic differentiation.
  • Some glands were filled with colloidlike secretion and had an inner, cuboidal epithelial cell layer (pankeratin, epithelial membrane antigen, and thyroid transcription factor-1 positive), surrounded by an outer layer of myoepithelial cells merging with foci of spindled myoepithelial cells (high molecular weight keratin, S100, smooth muscle actin, calponin, caldesmon, and p63 positive).
  • The biologic behavior to date has been benign.
  • This is the first reported series of a distinctive lung tumor with epithelial, myoepithelial, and pneumocytic differentiation that differs histologically from all previously recognized pulmonary salivary gland-type and pneumocytic tumors.
  • It is a unique benign appearing neoplasm for which the designation pneumocytic adenomyoepithelioma is suggested.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Female. Humans. Microscopy, Electron, Transmission. Middle Aged. Treatment Outcome

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  • (PMID = 17414103.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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40. Gupta C, Malani AK, Gupta V, Singh J, Ammar H: Metastatic retroperitoneal epithelioid angiomyolipoma. J Clin Pathol; 2007 Apr;60(4):428-31
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  • Angiomyolipoma (AML) is a rare benign neoplasm that usually arises in the kidneys, but may rarely originate in sites such as the retroperitoneum, liver and bone.
  • It is characterised by an intimate admixture of blood vessels, smooth muscle and fat.

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  • (PMID = 17405979.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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41. Nagai K, Aadachi K, Saito H: Huge pedunculated angiomyofibroblastoma of the vulva. Int J Clin Oncol; 2010 Apr;15(2):201-5
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  • We present the case of a huge pedunculated benign mesenchymal myxoid tumor that developed on the right labia majora of a 48-year-old-woman.
  • Microscopic examination revealed spindle and plump oval tumor cells arranged with abundant capillary vessels in an edematous stroma.
  • Immunohistochemical staining showed that the tumor cells were positive for vimentin, desmin, estrogen receptor, and progesterone receptor, but negative for alpha-smooth muscle actin, CD34, CD45, CD68, and S-100.
  • A pedunculated angiomyofibroblastoma is extremely rare and, to the best of our knowledge, this is the biggest such tumor in terms of size and weight reported to date.
  • It is especially important in such a huge mass greater than 10 cm that angiomyofibroblastoma is differentiated from aggressive angiomyxoma, which is a deeply invasive and recurrent neoplasm.

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  • (PMID = 20177728.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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42. Yen TH, Chen Y, Fu JF, Weng CH, Tian YC, Hung CC, Lin JL, Yang CW: Proliferation of myofibroblasts in the stroma of renal oncocytoma. Cell Prolif; 2010 Jun;43(3):287-96
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  • OBJECTIVES: Myofibroblasts are a vital component of stroma of many malignant neoplasms, but it is not yet established whether stromal myofibroblasts also exist in benign tumours such as oncocytoma of the kidney.
  • Wnt/beta-catenin signalling was not implicated in this neoplasm, as there was no loss of E-cadherin membranous localization or expression of intranuclear beta-catenin in the cells.
  • Importantly, alpha-smooth muscle actin (SMA)-immunostaining established the myofibroblastic nature of many of the stromal cells.
  • CONCLUSIONS: Renal oncocytomas were composed of two independent compartments: benign oncocytes and pronounced fibrotic stroma, which consisted of proliferating myofibroblasts (SMA- and MIB-1-positive) which were associated with excessive deposition of extracellular matrix (periodic acid Schiff-component, collagen I-, collagen III- and fibronectin-positive, and desmin- and human caldesmon-negative).
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Cell Proliferation. Extracellular Matrix / metabolism. Extracellular Matrix / pathology. Extracellular Matrix Proteins / metabolism. Female. Humans. Male. Middle Aged. Myoblasts / metabolism. Myoblasts / pathology. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / physiopathology. Stromal Cells / metabolism. Stromal Cells / pathology

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  • (PMID = 20412129.001).
  • [ISSN] 1365-2184
  • [Journal-full-title] Cell proliferation
  • [ISO-abbreviation] Cell Prolif.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Extracellular Matrix Proteins
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43. Ptacek T, Song C, Walker CL, Sell SM: Physical mapping of distinct 7q22 deletions in uterine leiomyoma and analysis of a recently annotated 7q22 candidate gene. Cancer Genet Cytogenet; 2007 Apr 15;174(2):116-20
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  • Uterine leiomyoma (UL) is a benign, smooth muscle tumor of the uterus affecting a significant proportion of women of reproductive age.

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  • (PMID = 17452252.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 5R25CA076023-07; United States / NIDDK NIH HHS / DK / P30DK056336
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Myelin Proteins; 0 / PMP22 protein, human
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44. Dalainas I: Vascular smooth muscle tumors: review of the literature. Int J Surg; 2008 Apr;6(2):157-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vascular smooth muscle tumors: review of the literature.
  • Vascular smooth muscle tumors are very rare.
  • They can be benign or malign.
  • Intravascular leiomyomatosis is a benign neoplasm that extends through the veins and caries significant morbidity.
  • Angioleiomyoma is a benign neoplasm of the extremities that caries minimal morbidity.
  • Vascular leiomyosarcomas are malign neoplasms derived from vascular smooth cells.
  • This study reviews literature for epidemiology, clinical presentation, diagnosis and management of patients with vascular smooth muscle tumors.
  • [MeSH-major] Neoplasms, Muscle Tissue / diagnosis. Neoplasms, Muscle Tissue / therapy. Vascular Neoplasms / diagnosis. Vascular Neoplasms / therapy

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  • (PMID = 17531562.001).
  • [ISSN] 1743-9159
  • [Journal-full-title] International journal of surgery (London, England)
  • [ISO-abbreviation] Int J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 70
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45. Huang KH, Huang CY, Chung SD, Pu YS, Shun CT, Chen J: Malignant epithelioid angiomyolipoma of the kidney. J Formos Med Assoc; 2007 Feb;106(2 Suppl):S51-4
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  • Angiomyolipoma (AML) is a common benign renal tumor composed of thick-walled blood vessels, smooth muscle, and adipose tissue, but the malignant epithelioid variant is extremely rare.
  • The tumor cells were positive for human melanosome-associated protein (HMB-45) on immunohistochemical staining.
  • Epithelioid AML is a potentially aggressive tumor.

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  • (PMID = 17493897.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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46. González Sánchez MA, Colorado Bonnin M, Berini Aytés L, Gay Escoda C: Leiomyoma of the hard palate: a case report. Med Oral Patol Oral Cir Bucal; 2007 May;12(3):E221-4
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  • Leiomyoma is a benign smooth muscle tumor that is very rarely located in the oral cavity.
  • It is accepted that the smooth muscle giving rise to this tumor corresponds to the tunica media of the arteries.
  • The tumor can develop at any age, with no clear gender predilection, and typically manifests as a slow-growing, asymptomatic lesion.
  • We present the case of a 57-year-old male with a tumor located for the previous four months in the region of the hard palate, adjacent to the left upper premolars.

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  • (PMID = 17468719.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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47. Kinkor Z, Skálová A, Michal M, Janousek M, Kheck M: [Metastasing and relapsing "low grade" adenosquamous metaplastic breast cancer--is there a really indolent lesion? A description of three cases and review of literature]. Ceska Gynekol; 2005 May;70(3):211-6
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  • RESULTS: Partial mastectomy and segmentectomy were performed in three women 46, 72 and 74 years-old resp. for tumor, which size ranged from 20-35 mm in maximum diameter (mean 28 mm).
  • The stromal component expressed smooth muscle actin in two cases, one of which contained areas of heterologous chondrosseal differentiation.
  • There were recognized metastases by one woman in two ipsilateral axillary lymph nodes mimicking benign breast heterotopia in one of them.
  • In two women with aggressive course the original biopsy was falsely interpreted, once as phyllodes tumor and secondly as benign sclerosing pseudotumor.
  • Low-grade adenosquamous carcinoma, however, has nothing to do with syringomatous adenoma of the nipple, which is a benign tumor of the skin adnexa.
  • Differential diagnosis includes spectrum of non-neoplastic slerosing lesions and above-mentioned phylloid tumor.
  • The rarity of this neoplasm does not exclude deep knowledge.


48. Azevedo Rde S, Pires FR, Della Coletta R, de Almeida OP, Kowalski LP, Lopes MA: Oral myofibromas: report of two cases and review of clinical and histopathologic differential diagnosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Jun;105(6):e35-40
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  • Myofibroma is a benign mesenchymal neoplasm composed of myofibroblasts which has been described with different synonyms since the first report in 1951.
  • Differential diagnosis included benign and malignant mesenchymal neoplasms, salivary gland tumors, and reactive processes.
  • Microscopic analysis of both lesions revealed a spindle cell tumor with immunoreactivity for vimentin, muscle-specific actin, and specific smooth muscle isoform alpha-actin, rendering the diagnoses of myofibroma.
  • Myofibroma presents a wide range of differential diagnosis, including benign and malignant neoplasms.

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  • (PMID = 18417385.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Vimentin
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49. Tse GM, Tan PH, Lui PC, Gilks CB, Poon CS, Ma TK, Law BK, Lam WW: The role of immunohistochemistry for smooth-muscle actin, p63, CD10 and cytokeratin 14 in the differential diagnosis of papillary lesions of the breast. J Clin Pathol; 2007 Mar;60(3):315-20
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  • [Title] The role of immunohistochemistry for smooth-muscle actin, p63, CD10 and cytokeratin 14 in the differential diagnosis of papillary lesions of the breast.
  • The evaluation of myoepithelial cells can be helpful, with benign papilloma showing a continuous myoepithelial cell layer, which becomes attenuated or absent in malignant papillary lesions.
  • METHODS: A large series of 100 papillomas (28 papillomas with florid epithelial hyperplasia) and 68 papillary carcinomas (9 invasive, 44 in situ, and 15 ductal carcinomas in situ (DCIS) involving papillomas) of the breast were stained for myoepithelial cells by immunohistochemistry using antibodies to smooth-muscle actin (SMA), p63, CD10 and cytokeratin (CK) 14.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Breast Neoplasms / metabolism
  • [MeSH-minor] Actins / metabolism. Adult. Aged. Aged, 80 and over. Carcinoma, Intraductal, Noninfiltrating / metabolism. Carcinoma, Intraductal, Noninfiltrating / pathology. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. DNA-Binding Proteins / metabolism. Diagnosis, Differential. Female. Humans. Keratin-14 / metabolism. Middle Aged. Neoplasm Proteins / metabolism. Neprilysin / metabolism. Papilloma / metabolism. Papilloma / pathology. Papilloma, Intraductal / metabolism. Papilloma, Intraductal / pathology. Trans-Activators / metabolism. Transcription Factors. Tumor Suppressor Proteins / metabolism

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  • (PMID = 16698948.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Keratin-14; 0 / Neoplasm Proteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; EC 3.4.24.11 / Neprilysin
  • [Other-IDs] NLM/ PMC1860581
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50. Meng GZ, Zhang HY, Bu H, Zhang XL, Pang ZG, Ke Q, Liu X, Yang G: Myofibroblastic sarcomas: a clinicopathological study of 20 cases. Chin Med J (Engl); 2007 Mar 5;120(5):363-9
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  • BACKGROUND: Myofibroblastic sarcoma was used to be a controversial neoplasm.
  • Immunohistochemically, the tumor cells expressed smooth muscle actin (18/20), muscle specific actin (16/20), fibronectin (20/20) and desmin (2/20).
  • Ultrastructurally, the tumor cells revealed abundant rough endoplasmic reticulum and longitudinally arranged fine filaments with focal densities in the cytoplasm.
  • CONCLUSIONS: Myofibroblastic sarcomas, which exhibit diverse histological appearance, can easily be misdiagnosed as benign tumors.

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  • (PMID = 17376304.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Desmin
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51. Driemel O, Berndt A, Hartmann A, Mueller-Richter UD, Bauer R, Reichert TE, Kosmehl H: [Clinical and immunohistochemical findings of intra- and extraoral angiosarcomas]. Mund Kiefer Gesichtschir; 2006 Jul;10(4):239-47
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  • For standardized immunohistochemistry following primary antibodies were applied: monoclonal antibodies to pancytoceratin clones AE1/AE3, alpha-smooth-muscle-actin clone 1A4, CD31 clone JC/70A, factor-VIII-related antigen clone F/86, Fli-1 (polyclonal, Zymed, USA), tenascin-C: BC4 (Prof. L.
  • RESULTS: While the benign appearance of the lesions resulted primarily in wrong diagnoses the histopathologic examination of the biopsies revealed the characteristic pattern of angiosarcomas.
  • The tumour associated structural defect of vascular lamina with partial loss of pericytes/vascular smooth muscle cells was identified immunohistochemically by alpha-smooth-muscle-actin and for the first time by tenascin-C.
  • ) The variable presentation and the benign appearance of oral and perioral angiosarcomas may often delay diagnosis.
  • Factor-VIII-related antigen, CD31 as well as Fli-1 identify angiosarcoma. (3.) alpha-smooth-muscle-actin and the loss of the tenascin-C-matrix indicate immunohistochemically the characteristic sarcomatous defect of differentiation.
  • [MeSH-major] Alveolar Process. Biomarkers, Tumor / analysis. Cheek. Hemangiosarcoma / pathology. Mandibular Neoplasms / pathology. Maxillary Sinus Neoplasms / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Aged. Humans. Male. Middle Aged. Neoplasm Invasiveness. Prognosis. Retrospective Studies

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  • (PMID = 16788797.001).
  • [ISSN] 1432-9417
  • [Journal-full-title] Mund-, Kiefer- und Gesichtschirurgie : MKG
  • [ISO-abbreviation] Mund Kiefer Gesichtschir
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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52. Jha P, Moosavi C, Fanburg-Smith JC: Giant cell fibroblastoma: an update and addition of 86 new cases from the Armed Forces Institute of Pathology, in honor of Dr. Franz M. Enzinger. Ann Diagn Pathol; 2007 Apr;11(2):81-8
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  • All cases had benign behavior, but almost half recurred.
  • The caveat was mistaking this tumor for a malignancy.
  • They proposed a relationship of this childhood tumor to dermatofibrosarcoma protuberans (DFSP).
  • Most cases were dermal and subcutaneous, 3 purely dermal, and 5 involved superficial skeletal muscle.
  • Two cases of pure GCF recurred as a hybrid tumor with DFSP areas, one of these with hypercellular DFSP.
  • Most cases studied were positive for CD34 (more intense in DFSP than relatively hypocellular GCF areas) and negative for smooth muscle actin, desmin, HMB-45, keratin, and S100 protein.
  • Additional observations of marked perivascular and onionskin-like chronic inflammation and consistent hemorrhage may aid in the diagnosis of this previously well-described tumor.
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / metabolism. Child. Child, Preschool. Female. History, 20th Century. Humans. Infant. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Registries

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  • (PMID = 17349565.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Biography; Historical Article; Journal Article; Portraits
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Personal-name-as-subject] Enzinger FM
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53. Anurova OA, Snigur PV, Filippova NA, Sel'chuk VIu: [Morphological characteristics of stromal gastrointestinal tumors]. Arkh Patol; 2006 Jan-Feb;68(1):10-3
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  • Stromal tumors are singled out from smooth muscle and neurogenic neoplasms into a special group due to differences in CD117 expression caused by mutation of c-kit gene.
  • Smooth muscle actin was found in 82% tumors, S-100 protein in 75%, neuron-specific enolase in 66% cases.
  • Malignant tumors were in 93% cases, and in 7% benign.
  • [MeSH-major] Gastrointestinal Stromal Tumors / metabolism. Gastrointestinal Stromal Tumors / pathology. Neoplasm Proteins / biosynthesis

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  • (PMID = 16544528.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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54. Zhen B, Shen Y, Zhang YM, Zhu CH, Liu ZL: [Analysis of the differences in the expression of HSP27 and c-kit between benign prostatic hyperplasia and prostatic cancer tissues]. Zhonghua Nan Ke Xue; 2006 May;12(5):416-20
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  • [Title] [Analysis of the differences in the expression of HSP27 and c-kit between benign prostatic hyperplasia and prostatic cancer tissues].
  • OBJECTIVE: To examine the differences in the expression of HSP27 and c-kit between benign prostatic hyperplasia (BPH) and prostatic cancer (PCa) tissues and to analyse the relationship between their expression and BPH and PCa, especially the relationship with the occurrence, development, prognosis and treatment of PCa.
  • The staining for c-kit in BPH tissues was located in the cytoplasm of smooth muscle cells, and in PCa tissues was located in epithelial cells.
  • CONCLUSION: The expression level of HSP27 and c-kit was highly correlated with the process of the development from BPH to PCa, and also correlated with tumor grades and stages.
  • [MeSH-major] Heat-Shock Proteins / biosynthesis. Neoplasm Proteins / biosynthesis. Prostatic Hyperplasia / metabolism. Prostatic Neoplasms / metabolism. Proto-Oncogene Proteins c-kit / biosynthesis


55. Nocito MJ, Lustia MM, Luna PC, Cañadas NG, Castellanos Posse ML, Marchesi C, Carabajal G, Mazzini MA: Atypical leiomyoma: An unusual variant of cutaneous pilar leiomyoma. Dermatol Online J; 2009;15(3):6
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  • Cutaneous atypical leiomyoma is an unusual benign tumor arising from arrector pili muscle that shares histological features with uterine atypical or symplastic leiomyoma: atypical cellularity with pleomorphic nuclei but minimal or no mitosis.
  • Six other cases have been reported so far and, in spite of its name and of being a smooth muscle proliferation, no recurrences nor metastasis have been reported.
  • [MeSH-minor] Actins / analysis. Aged. Biomarkers, Tumor / analysis. Desmin / analysis. Diagnosis, Differential. Female. Humans. Leiomyosarcoma / diagnosis. Mitotic Index. Neoplasm Proteins / analysis

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  • (PMID = 19379650.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Desmin; 0 / Neoplasm Proteins
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56. Tzanakis NE, Giannopoulos GA, Efstathiou SP, Rallis GE, Nikiteas NI: Angiomyofibroblastoma of the spermatic cord: a case report. J Med Case Rep; 2010;4:79
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  • INTRODUCTION: Angiomyofibroblastoma is a benign soft tissue tumor with tendency to arise in the vulva.
  • At operation, a 4.5 cm well-circumscribed solid tumor was found adherent to the spermatic cord.
  • The tumor consisted of spindle-shaped cells proliferating in short fascicles between numerous medium-sized blood vessels with thin and hyalinized walls.
  • Immunostaining showed positivity for vimentin, CD34, desmin and smooth muscle actin.
  • CONCLUSION: This unusual neoplasm should be distinguished from aggressive angiomyxoma and other myxoid malignant tumors with widespread metastatic potential.

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  • (PMID = 20202207.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2838917
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57. Miettinen M, Makhlouf HR, Sobin LH, Lasota J: Plexiform fibromyxoma: a distinctive benign gastric antral neoplasm not to be confused with a myxoid GIST. Am J Surg Pathol; 2009 Nov;33(11):1624-32
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  • [Title] Plexiform fibromyxoma: a distinctive benign gastric antral neoplasm not to be confused with a myxoid GIST.
  • A great majority of gastric mesenchymal tumors are gastrointestinal stromal tumor (GIST).
  • In this report, we describe 12 cases of a distinctive gastric tumor, named here as plexiform fibromyxoma.
  • The tumor cells varied from oval to spindled and had limited atypia and mitotic activity < 5/50 high-power fields.
  • Immunohistochemically, the tumor cells were positive for alpha smooth muscle actin, and variably for CD10, and were consistently negative for KIT, DOG1, CD34, desmin, and S100 protein.
  • Additional 3 patients survived 14 to 25 years with unknown tumor status.
  • Plexiform fibromyxoma is a distinctive benign gastric antral neoplasm that should be separated from GIST, nerve sheath tumors, and other fibromyxoid neoplasms.
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Child. Diagnosis, Differential. Disease-Free Survival. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Invasiveness. Young Adult

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  • (PMID = 19675452.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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58. Rodriguez FJ, Aubry MC, Tazelaar HD, Slezak J, Carney JA: Pulmonary chondroma: a tumor associated with Carney triad and different from pulmonary hamartoma. Am J Surg Pathol; 2007 Dec;31(12):1844-53
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  • [Title] Pulmonary chondroma: a tumor associated with Carney triad and different from pulmonary hamartoma.
  • Their pulmonary neoplasm(s) were usually asymptomatic, often multiple, well circumscribed, medium-sized (mean diameter=2.8 cm), and composed almost exclusively of cartilage and bone surrounded by a fibrous pseudocapsule.
  • They showed no fat, smooth muscle or entrapped respiratory epithelium, tissues that were common in pulmonary hamartoma (P<0.0001).
  • The pulmonary neoplasms in the Carney triad are well-differentiated benign cartilaginous tumors that are best designated as chondromas.

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  • (PMID = 18043038.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Chaudhry IH, Calonje E: Dermal non-neural granular cell tumour (so-called primitive polypoid granular cell tumour): a distinctive entity further delineated in a clinicopathological study of 11 cases. Histopathology; 2005 Aug;47(2):179-85
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  • AIMS: Cutaneous and soft tissue granular cell tumour is a well-characterized benign neoplasm of neural origin.
  • There was negative staining for S100 protein, smooth muscle actin, Melan-A, CD34, desmin and cytokeratin.
  • [MeSH-major] Granular Cell Tumor / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Biomarkers, Tumor / analysis. Child. Factor XIIIa / analysis. Female. Humans. Immunohistochemistry. Lysosomes / immunology. Male. Middle Aged

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  • (PMID = 16045779.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human; EC 2.3.2.13 / Factor XIIIa
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60. Ghazali N, Cascarini L, Norris P, Barrett AW, Lavery KM: Perivascular epithelioid cell tumor (PEComa) of the cheek. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Jul;110(1):e26-31
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  • [Title] Perivascular epithelioid cell tumor (PEComa) of the cheek.
  • We present the unusual case of a perivascular epithelioid cell tumor (PEComa) occurring within the cheek of a 32-year-old woman.
  • PEComa is a rare, recently described, family of tumors with diverse clinicopathologic expression and which express melanocytic and muscle markers.
  • Other possible diagnoses considered included benign mesenchymal tumors of smooth muscle or neural origin.
  • The tumor was completely excised, but in view of uncertainty as to how this entity would behave in an unusual location, lifelong follow up is recommended.
  • [MeSH-minor] Actins / analysis. Adult. Antigens, Neoplasm / analysis. Arterioles / pathology. Diagnosis, Differential. Epithelioid Cells / pathology. Female. Follow-Up Studies. Humans. MART-1 Antigen. Muscle, Smooth, Vascular / pathology. Neoplasm Proteins / analysis

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  • [Copyright] Copyright (c) 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20610292.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Neoplasm Proteins
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61. Gupta R, Singh S, Khurana N: Leiomyoma of the prostate--a rare mesenchymal tumor: a case report. Indian J Pathol Microbiol; 2007 Apr;50(2):403-5
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  • [Title] Leiomyoma of the prostate--a rare mesenchymal tumor: a case report.
  • Prostatic enlargement due to benign adenomatous hyperplasia is very common in elderly males.
  • However, benign mesenchymal tumors, especially true leiomyoma, are rare in prostate.
  • True prostatic leiomyoma has been defined by Kaufman and Berneike as a smooth muscle tumor within the prostate or juxta-prostatic in position, devoid of glandular elements.
  • A suprapubic prostatectomy was performed, and histopathological examination revealed a benign smooth muscle tumor (confirmed by immunohistochemistry), in absence of glandular hyperplasia.
  • True leiomyoma is a rare tumor in prostate, which can be diagnosed only on histopathological examination.

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  • (PMID = 17883092.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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62. Lazović G, Milićević S, Atanacković J, Milosevic V, Bozanović T, Gojnić M: Leiomyoma of the uterus and retroperitoneal angioleiomyoma: case report. Clin Exp Obstet Gynecol; 2007;34(4):257-8
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  • Retroperitoneal angioleiomyoma is a benign mesenchymal neoplasm that is composed of smooth muscle cells and thick-walled vessels.
  • In a 36-year-old patient a retrouterine and retroperitoneal tumor, 70 x 65 x 50 mm in size, was discovered during a surgical procedure due to uterine myoma.
  • The tumor had a soft consistency and was completely removed.
  • Angioleiomyoma is a rare benign entity; hence a benign course and good prognosis are expected.

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  • (PMID = 18225694.001).
  • [ISSN] 0390-6663
  • [Journal-full-title] Clinical and experimental obstetrics & gynecology
  • [ISO-abbreviation] Clin Exp Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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63. Agarwal S, Gupta SK, Tejwani N: Angioleiomyoma of broad ligament. J Gynecol Endosc Surg; 2009 Jul;1(2):116-7
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  • Angioleiomyoma is an uncommon benign mesenchymal neoplasm that originates from smooth muscle cells and contains numerous thick-walled blood vessels.

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  • (PMID = 22442524.001).
  • [ISSN] 0974-1216
  • [Journal-full-title] Journal of gynecological endoscopy and surgery
  • [ISO-abbreviation] J Gynecol Endosc Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3304275
  • [Keywords] NOTNLM ; Angioleiomyoma / broad ligament / capillary
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64. Kubo M, Ihn H, Yamane K, Tamaki K: The expression levels and the differential expression of transforming growth factor-beta receptors in dermatofibroma and dermatofibrosarcoma protuberans. Br J Dermatol; 2006 May;154(5):919-25
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  • BACKGROUND: Dermatofibroma (DF) and dermatofibrosarcoma protuberans (DFSP) are benign and intermediate malignant fibrotic dermal tumours, respectively.
  • RESULTS: We detected strong expression of TGFbeta-RI and TGFbeta-RII on epidermis and epidermal appendages, moderate expression in vascular endothelial cells, smooth muscle cells and neural tissues, and weak expression in fibroblasts in normal skin sections.
  • [MeSH-major] Dermatofibrosarcoma / metabolism. Histiocytoma, Benign Fibrous / metabolism. Neoplasm Proteins / metabolism. Receptors, Transforming Growth Factor beta / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Activin Receptors, Type I / genetics. Activin Receptors, Type I / metabolism. Adult. Biomarkers, Tumor / metabolism. Collagen Type I / metabolism. Diagnosis, Differential. Female. Humans. In Situ Hybridization. Male. Middle Aged. Protein-Serine-Threonine Kinases. RNA, Messenger / genetics. Skin / metabolism. Up-Regulation

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  • (PMID = 16634896.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Collagen Type I; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / Receptors, Transforming Growth Factor beta; EC 2.7.1.11 / TGF-beta type I receptor; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.30 / Activin Receptors, Type I; EC 2.7.11.30 / transforming growth factor-beta type II receptor
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65. Kim K, Velez I, Kaltman SI, Lopez E, Stern D: Odontogenic carcinoma differentiation into rhabdomyosarcoma: report of a rare case. Quintessence Int; 2009 Nov-Dec;40(10):837-42
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  • To the authors' knowledge, this is the first reported case of an odontogenic carcinoma with documented skeletal muscle differentiation (rhabdomyosarcoma).
  • The histology and clinical features of this aggressive odontogenic neoplasm are described.
  • Within the English-language literature, only 2 cases are reported of an odontogenic tumor with muscle differentiation: a benign odontogenic tumor (ameloblastoma) with differentiation into a rhabdomyosarcoma and an odontogenic sarcoma with smooth-muscle differentiation.

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  • (PMID = 19898715.001).
  • [ISSN] 1936-7163
  • [Journal-full-title] Quintessence international (Berlin, Germany : 1985)
  • [ISO-abbreviation] Quintessence Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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66. Ausmus GG, Piliang MP, Bergfeld WF, Goldblum JR: Soft-tissue perineurioma in a 20-year-old patient with neurofibromatosis type 1 (NF1): report of a case and review of the literature. J Cutan Pathol; 2007 Sep;34(9):726-30
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  • BACKGROUND: Perineurioma is a rare benign soft-tissue tumor composed of cells showing differentiation toward the perineurial cells of the nerve sheath.
  • Although mutations in the neurofibromatosis 2 (NF2) gene have been documented in this tumor, there is no known association between perineuriomas and type 1 or 2 NF.
  • RESULTS: Histopathologic examination revealed a 2.0-cm well-circumscribed, spindle-cell neoplasm with slender, elongated, bipolar, wavy cytoplasmic processes and wavy, elongated nuclei in a hyalinized stroma with focal myxoid areas.
  • Immunohistochemistry showed positive labeling for epithelial membrane antigen (EMA) but no staining for S-100 and smooth muscle actin (SMA).
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Female. Humans. Mucin-1 / metabolism. Thorax. Tomography, X-Ray Computed. Treatment Outcome


67. Li T, Wang L, Yu HH, Sun HC, Qin LX, Ye QH, Fan J, Tang ZY: Hepatic angiomyolipoma: a retrospective study of 25 cases. Surg Today; 2008;38(6):529-35
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  • PURPOSE: We report our experience of diagnosing and treating hepatic angiomyolipoma (HAML), a rare benign mesenchymal tumor.
  • All tumors were composed of varying proportions of smooth muscle, adipose tissue, and blood vessels, and showed positive immunohistochemical staining for HMB-45.
  • [MeSH-minor] Adolescent. Adult. Antigens, Neoplasm / analysis. Female. Hepatectomy. Humans. Magnetic Resonance Imaging. Male. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / analysis. Prognosis. Retrospective Studies. Tomography, X-Ray Computed. Ultrasonography

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  • (PMID = 18516533.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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68. Kim HJ, Lee KY, Kim YW: Case report: Imaging features of perianal leiomyoma. Br J Radiol; 2009 Aug;82(980):e168-70
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  • A leiomyoma is a benign mesenchymal neoplasm that usually develops where smooth muscle is present.

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  • [ErratumIn] Br J Radiol. 2010 Jan;83(985):88. Lee, G H [corrected to Lee, K Y]
  • (PMID = 19592401.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media
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69. Angiero F, Sozzi D, Seramondi R, Valente MG: Epithelial-myoepithelial carcinoma of the minor salivary glands: immunohistochemical and morphological features. Anticancer Res; 2009 Nov;29(11):4703-9
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  • AIMS: Epithelial-myoepithelial carcinoma (EMC) is a rare malignant salivary gland neoplasm that most commonly occurs in the parotid gland, but can also arise in the minor salivary glands.
  • All parts of each tumor were surrounded by a myoepithelial cell rim and there was evidence of invasion.
  • RESULTS: Immunohistochemical analysis showed the tumor cells to be weakly positive for S100, cytokeratin (CK) CK5/6, CK7, CKAE-1/AE-3 and strongly positive for epithelial membrane antigen (EMA) and p63; they were focally positive for calponin and acute lymphoblastic leukemia antigen (CD10).
  • The tumor cells were negative for vimentin, alpha-smooth muscle actin (SMA) (except one case), glial fibrillar acid protein (GFAP) and MIB1.
  • CONCLUSION: Three cases of minor salivary gland tumors are described and the differential diagnosis underlined in relation to benign myoepithelioma.


70. Mentzel T, Kutzner H: Dermatomyofibroma: clinicopathologic and immunohistochemical analysis of 56 cases and reappraisal of a rare and distinct cutaneous neoplasm. Am J Dermatopathol; 2009 Feb;31(1):44-9
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  • [Title] Dermatomyofibroma: clinicopathologic and immunohistochemical analysis of 56 cases and reappraisal of a rare and distinct cutaneous neoplasm.
  • Dermatomyofibroma represents a rare and distinct benign cutaneous mesenchymal neoplasm of fibroblastic/myofibroblastic differentiation.
  • Histologically, an ill-defined, plaque-like dermal neoplasm of varying cellularity was seen in all cases, composed of bland spindle-shaped tumor cells often oriented parallel to the overlying epidermis.
  • Immunohistochemically, tumor cells in 11 of 48 cases tested stained positively for alpha-smooth muscle actin, and a focal expression of this marker was noted in 20 cases.
  • Dermatomyofibroma represents a benign fibroblastic/myofibroblastic dermal neoplasm.
  • [MeSH-major] Histiocytoma, Benign Fibrous / metabolism. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / metabolism. Skin Neoplasms / pathology

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  • (PMID = 19155724.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Hua W, Xu F, Mao Y, Zhang J, Wang Y, Mao R, Zhou L: Primary intracranial leiomyomas: Report of two cases and review of the literature. Clin Neurol Neurosurg; 2009 Dec;111(10):907-12
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  • A leiomyoma is a benign neoplasm composed of smooth muscle cells that commonly occurs in the genitourinary and gastrointestinal tracts.
  • Pathological analysis with immunohistochemistry revealed that tumors had characteristics of benign smooth muscles.

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  • (PMID = 19740596.001).
  • [ISSN] 1872-6968
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Nerve Tissue Proteins
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72. Brasileiro BF, Martins-Filho PR, Piva MR, da Silva LC, Nonaka CF, Miguel MC: Myofibroma of the oral cavity. A rare spindle cell neoplasm. Med Oral Patol Oral Cir Bucal; 2010 Jul;15(4):e596-600
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  • [Title] Myofibroma of the oral cavity. A rare spindle cell neoplasm.
  • Myofibroma is an uncommon spindle cell neoplasm rarely found in oral cavity.
  • Misdiagnosis included benign and malignant spindle cell lesions of nerve tissue or smooth muscle origin, such as neurofibroma, leiomyoma and sarcomas.

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  • (PMID = 20038894.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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73. Khoo JJ, Alwi RI, Abd-Rahman I: Myoid hamartoma of breast with chondroid metaplasia: a case report. Malays J Pathol; 2009 Jun;31(1):77-80
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  • Breast hamartoma is an uncommon poorly recognised benign breast neoplasm.
  • Hamartoma displaying marked smooth muscle components known as myoid hamartoma of the breast is a much rarer entity.
  • Microscopically, it composed of many groups of mammary glandular components with dense fibrous stroma, adipose tissue and marked groups of smooth muscle fibres.
  • The smooth muscle cells showed strong and diffuse immunoreactivity for vimentin, myogloblin, alpha-smooth muscle actin, desmin and CD34 and failed to express pan-cytokeratin or S100 protein.
  • The various immuno-histochemical staining as well as the cyto-histological changes encountered in myoid hamartomas are discussed with clinical, radiological and pathological correlation to differentiate it from other benign and malignant breast lesions.
  • [MeSH-major] Breast Diseases / pathology. Hamartoma / pathology. Muscle, Smooth / pathology

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  • (PMID = 19694319.001).
  • [ISSN] 0126-8635
  • [Journal-full-title] The Malaysian journal of pathology
  • [ISO-abbreviation] Malays J Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Malaysia
  • [Chemical-registry-number] 0 / Biomarkers
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74. Lincoln DT, Singal PK, Al-Banaw A: Growth hormone in vascular pathology: neovascularization and expression of receptors is associated with cellular proliferation. Anticancer Res; 2007 Nov-Dec;27(6B):4201-18
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  • Growth hormone (GH) is mitogenic for a variety of vascular tissue cells, including smooth muscle cells, fibroblasts and endothelial cells and exerts its regulatory functions in controlling metabolism, balanced growth and differentiated cell expression by acting on specific membrane-bound receptors, which trigger a phosphorylation cascade resulting in the modulation of numerous signalling pathways and of gene expression.
  • A total of 64 benign and malignant vascular tumours were obtained from different human organ sites, including the chest wall, skin, axillary contents, duodenum, female breast, abdomen, stomach, colon, lymph node, bladder, body flank and neck regions.
  • The presence of GHR in endothelial cells of vascular neoplasm indicates that they are target cells and GH is of importance in the proliferation of vascular tumour angiogenesis.

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  • [ErratumIn] Anticancer Res. 2008 Mar-Apr;28(2b):1439
  • (PMID = 18225592.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Receptors, Somatotropin; 9002-72-6 / Growth Hormone
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75. Zhang YX, Chen HL, Ye B, Yang F, Yu LY: [Study on expression and methylation of caveolin 1 gene in non-small cell lung cancers]. Zhonghua Bing Li Xue Za Zhi; 2008 May;37(5):300-4
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  • METHODS: Immunohistochemistry and quanta Qd600 staining were used to detect the expression of Cav-1 in tissues from benign lung lesions (n = 17) and NSCLC (n = 123).
  • RESULTS: Cav-1 protein was highly expressed in cytoplasm and cell membrane of normal bronchial epithelium, alveolar epithelium, endothelial cells, fibroblasts and smooth muscle cells.
  • Amongst the NSCLC group, there was no statistically significant difference in Cav-1 protein expression in different histologic types (P = 0.552) and tumor grades (P = 0.160).
  • On the other hand, Cav-1 protein immunoreactivity was remarkably higher in advanced tumor stage: 72.7% in stage III A + III B, compared with 9.4% in stage I A + I B and 38.3% in stage II A + II B (P = 0.001).
  • CONCLUSIONS: High expression of Cav-1 protein is respected of the aggressive clinical behavior and advanced tumor stage.
  • [MeSH-minor] Aged. DNA Methylation. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging / methods. Somatoform Disorders

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  • (PMID = 18956646.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Caveolin 1
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76. Koyuncu BO, Zeytinoğlu M, Unal T, Zeytinoğlu B: Myofibroma of the gingiva: report of a case. J Clin Pediatr Dent; 2010;34(3):253-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Myofibroma is a benign mesenchymal neoplasm composed of myofibroblasts which has been described with different synonyms since the first report in 1951.
  • Awareness and recognition of this benign tumor is important to establish the correct diagnosis and avoid morbidity of unnecessary aggressive therapy.
  • The tumor showed rapid increase in size and clinical features suggestive of malignancy.
  • However on histopathologic evaluation it was diagnosed as a benign neoplasm, and this diagnosis was supported by immunohistochemical markers.
  • The spindle cells were immunopositive for smooth muscle actin, and vimentin but were negative for desmin and S-100 protein.

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  • (PMID = 20578664.001).
  • [ISSN] 1053-4628
  • [Journal-full-title] The Journal of clinical pediatric dentistry
  • [ISO-abbreviation] J Clin Pediatr Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Desmin; 0 / S100 Proteins; 0 / Vimentin
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77. Ma L, Kowalski D, Javed K, Hui P: Atypical angiomyolipoma of kidney in a patient with tuberous sclerosis: a case report with p53 gene mutation analysis. Arch Pathol Lab Med; 2005 May;129(5):676-9
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  • Angiomyolipoma (AML) is the most common benign mesenchymal tumor of the kidney.
  • It belongs to the family of perivascular epithelioid cell tumors and is typically composed of blood vessels, adipose tissue, and smooth muscle- like cells, which are characteristically positive for HMB-45.
  • The tumor consisted of mostly epithelioid cells with marked nuclear pleomorphism and frequent mitoses and was positive for HMB-45.
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Cytoplasm / ultrastructure. DNA Mutational Analysis. DNA, Neoplasm / genetics. Female. Humans. Immunohistochemistry. Intercellular Junctions / ultrastructure. Nephrectomy. Polymerase Chain Reaction. Polymorphism, Single-Stranded Conformational. Treatment Outcome


78. Petrolla AA, Xin W: Hepatic angiomyolipoma. Arch Pathol Lab Med; 2008 Oct;132(10):1679-82
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  • Hepatic angiomyolipoma is a rare, benign, hepatic mesenchymal neoplasm found in both males and females, and most commonly in adult females.
  • Hepatic angiomyolipomas are composed of varying amounts of smooth muscle cells, adipose tissue, and vessels.
  • The smooth muscle cell component is the most specific to the diagnosis.
  • The smooth muscle cells can have varying morphologies and are positive for homatropine methylbromide-45 but are negative for hepatocyte paraffin 1 and S100 protein.
  • The differential diagnosis includes hepatocellular carcinoma, hepatic adenoma, leiomyoma, hepatoblastoma, melanoma, and gastrointestinal stromal tumor.
  • The immunohistochemical staining pattern differentiates this lesion from other malignant and benign liver lesions.
  • [MeSH-minor] Antigens, Neoplasm / metabolism. Female. Humans. MART-1 Antigen. Male. Melanoma-Specific Antigens. Neoplasm Proteins / metabolism. S100 Proteins / metabolism

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  • The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for hepatic angiomyolipoma .
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  • (PMID = 18834230.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins
  • [Number-of-references] 17
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79. Pedemonte JG, Degiovanni D, Pusterla D, Reibel C, Di Nucci J, Boccio C, Degiovanni R, Dotta A: [Angiomyolipoma and Lenk syndrome: case report]. Actas Urol Esp; 2008 Sep;32(8):850-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Angiomyolipoma (AML) is a benign clonal neoplasm that consists of varying amounts of mature adipose tissue, smooth muscle, and thick-walled vessels.

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  • (PMID = 19013986.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas espanolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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80. Moon H, Park SJ, Lee HB, Kim SR, Choe YH, Chung MJ, Jin GY, Lee YC: Pulmonary benign metastasizing leiomyoma in a postmenopausal woman. Am J Med Sci; 2009 Jul;338(1):72-4
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  • [Title] Pulmonary benign metastasizing leiomyoma in a postmenopausal woman.
  • Pulmonary benign metastasizing leiomyoma (BML) is a rare disease occurring predominantly in women of reproductive age and usually develops several years after the resection of a uterine leiomyoma.
  • A wedge biopsy revealed the pulmonary nodule consisting of branching glandular structures surrounded by abundant smooth muscle cells with no atypia.
  • We performed a gynecologic examination to identify the primary origin of the pulmonary smooth muscle tumors.
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Metastasis. Postmenopause

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  • (PMID = 19506459.001).
  • [ISSN] 0002-9629
  • [Journal-full-title] The American journal of the medical sciences
  • [ISO-abbreviation] Am. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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81. Durgun Y, Firat C, Miman MC, Kirimlioglu H: A rare benign laryngeal tumor: angiomyolipoma. J Craniofac Surg; 2010 Nov;21(6):1956-7
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  • [Title] A rare benign laryngeal tumor: angiomyolipoma.
  • Angiomyolipoma is a mesenchymal neoplasm containing adipose tissue, blood vessels, and smooth muscle fibers.
  • Arising most frequently in the kidney, the tumor may exceptionally be at the head and neck region.
  • The tumor was removed by an endolaryngeal approach.

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  • (PMID = 21119467.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. Pacchioni D, Volante M, Casetta G, Sapino A, Marchiò C, Bussolati G: Myxoid renal tumor with myoepithelial differentiation mimicking a salivary gland pleomorphic adenoma: description of a case. Am J Surg Pathol; 2007 Apr;31(4):632-6
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  • [Title] Myxoid renal tumor with myoepithelial differentiation mimicking a salivary gland pleomorphic adenoma: description of a case.
  • We herein report an unusual case of a low-grade myxoid renal epithelial neoplasm, with peculiar and previously unreported morphologic and immunohistochemical features.
  • The immunohistochemical profile interestingly confirmed the myoepithelial differentiation of the basal epithelial layer, as demonstrated by the coexpression of several myoepithelial markers such as p63, caldesmon, calponin, smooth muscle actin, and S-100, together with epithelial markers such as low and high-molecular weight cytokeratins.
  • The tumor proved benign at follow-up.
  • A definitive classification and histogenetic interpretation of this previously unreported tumor type awaits description of further cases showing similar features which, perhaps, as it may happen, went so far unnoticed.
  • [MeSH-minor] Adenoma, Pleomorphic / pathology. Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Salivary Gland Neoplasms / pathology

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  • (PMID = 17414112.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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83. Kamboj S, Sharma RK, Kumar A, Chaudhary SS, Jain VK: Crusted Piloleiomyoma with mental retardation: a rare association. Indian J Dermatol; 2009;54(1):75-6
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  • Piloleiomyoma is an uncommon benign smooth muscle neoplasm arising from arrector pili muscle.
  • It is clinically defined by the presence of solitary or multiple reddish brown, dome-shaped, smooth papules or nodules, ranging in size from a few millimeters to a centimeter.
  • In this case report, a mentally retarded patient with Piloleiomyoma is described, who, besides the characteristic smooth and dome-shaped lesions on the anterolateral aspect of the dorsum of the right foot, had developed crusting on one of the largest lesions.

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  • [Cites] J Dermatol. 1996 Jan;23(1):56-7 [8720260.001]
  • [Cites] Am J Hum Genet. 2001 May;68(5):1264-9 [11283798.001]
  • [Cites] J Reprod Med. 2006 Sep;51(9):747-50 [17039711.001]
  • (PMID = 20049278.001).
  • [ISSN] 1998-3611
  • [Journal-full-title] Indian journal of dermatology
  • [ISO-abbreviation] Indian J Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2800880
  • [Keywords] NOTNLM ; Crusting / mental retardation / piloleiomyoma
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84. Pauli J, Gundelach R, Vanelli-Rees A, Rees G, Campbell C, Dubey S, Perry C: Juvenile nasopharyngeal angiofibroma: an immunohistochemical characterisation of the stromal cell. Pathology; 2008 Jun;40(4):396-400
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  • Although histologically benign, it can be locally aggressive with a significant recurrence rate.
  • Of 54 cases, 22 contained a microvascular component (usually peripherally located and indicating the active growth front of the tumour) in which the stromal cells demonstrated a hybrid immunophenotype with both smooth muscle and endothelial differentiation. c-kit was negative in all cases.
  • In the microvascular component the stromal cells appear able to show smooth muscle or endothelial differentiation.
  • [MeSH-major] Angiofibroma / pathology. Biomarkers, Tumor / analysis. Immunoenzyme Techniques / methods. Nasopharyngeal Neoplasms / pathology. Neoplasm Proteins / analysis

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  • (PMID = 18446631.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Vimentin
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85. Zustin J, Akpalo H, Gambarotti M, Priemel M, Rueger JM, Luebke AM, Reske D, Lange C, Pueschel K, Lohmann C, Rüther W, Amling M, Alberghini M: Phenotypic diversity in chondromyxoid fibroma reveals differentiation pattern of tumor mimicking fetal cartilage canals development: an immunohistochemical study. Am J Pathol; 2010 Sep;177(3):1072-8
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  • [Title] Phenotypic diversity in chondromyxoid fibroma reveals differentiation pattern of tumor mimicking fetal cartilage canals development: an immunohistochemical study.
  • Chondromyxoid fibroma represents a rare benign cartilaginous tumor of young patients occurring in a subcortical metaphyseal location.
  • Archival paraffin-embedded tissues from 4 fetal femora and 10 cases of chondromyxoid fibroma were analyzed simultaneously using histochemistry (safranin O) and established immunohistochemical antibodies (CD34, CD163, and smooth muscle actin).
  • Based on the observed substantial morphological similarity between the cartilage canals and chondromyxoid fibroma, we suggest that the chondromyxoid fibroma represents a neoplasm originating from or mimicking the fetal cartilage canals within the immature cartilage.

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  • (PMID = 20671262.001).
  • [ISSN] 1525-2191
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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86. Nguyen TT, Gorman B, Shields D, Goodman Z: Malignant hepatic angiomyolipoma: report of a case and review of literature. Am J Surg Pathol; 2008 May;32(5):793-8
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  • Hepatic angiomyolipoma, a constituent of the group of tumors showing differentiation resembling perivascular epithelioid cells, is primarily appreciated in its benign form.
  • These tumors also possess similar immunohistochemical profiles, including positivity for melanocytic (HMB-45) and smooth muscle (smooth muscle actin) markers.
  • We will discuss the features that aid in distinguishing between benign and malignant HAML, and their similarities.
  • In summary, the common features of both benign and malignant HAML include the following: the 3 basic histologic components of AML, expression of melanocytic and smooth muscle markers, invasion into adjacent normal parenchyma, and cytologic atypia.
  • [MeSH-minor] Adipocytes / chemistry. Adipocytes / pathology. Adult. Antigens, Neoplasm / analysis. Biomarkers, Tumor / analysis. Fatal Outcome. Female. Hepatectomy. Humans. Melanoma-Specific Antigens. Neoplasm Metastasis. Neoplasm Proteins / analysis. Neoplasm Recurrence, Local

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  • (PMID = 18391749.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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87. Veit AC, Painter JT, Miller RA, Hardisty JF, Dixon D: Characterization of uterine granular cell tumors in B6C3F1 mice: a histomorphologic, immunohistochemical, and ultrastructural study. Vet Pathol; 2008 Sep;45(5):654-62
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  • The granular cell tumor is most often a benign neoplasm of uncertain origin.
  • Tissue sections were evaluated histologically and stained with hematoxylin and eosin, periodic acid-Schiff with diastase resistance, Masson's trichrome, toluidine blue, phosphotungstic acid-hematoxylin, and stained immunohistochemically with a panel of antibodies to muscle (desmin, alpha smooth muscle actin), neural (S-100, neuron specific enolase), epithelial (wide-spectrum cytokeratin), and macrophage (F4/80) markers.
  • The main histomorphologic feature of tumor cells was the presence of abundant cytoplasmic eosinophilic granules that stained positive for periodic acid-Schiff with diastase resistance.
  • Three tumors had positive to weakly positive immunoreactivity for desmin, and 1 was positive for alpha smooth muscle actin.
  • [MeSH-major] Granular Cell Tumor / veterinary. Uterine Neoplasms / veterinary

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  • (PMID = 18725470.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 ES999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS103826; NLM/ PMC2691646
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88. Lee HJ, Choi J, Kim KR: Pulmonary benign metastasizing leiomyoma associated with intravenous leiomyomatosis of the uterus: clinical behavior and genomic changes supporting a transportation theory. Int J Gynecol Pathol; 2008 Jul;27(3):340-5
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  • [Title] Pulmonary benign metastasizing leiomyoma associated with intravenous leiomyomatosis of the uterus: clinical behavior and genomic changes supporting a transportation theory.
  • Benign metastasizing leiomyoma is a rare lesion characterized by benign-appearing smooth muscle tumor most frequently involving the lung and usually associated with a benign leiomyoma or intravenous leiomyomatosis of the uterus.
  • The pathogenetic mechanism of the tumor has not been clarified, but the possibilities including hormone-sensitive in situ proliferations of smooth muscle bundles, mechanical displacement or intravascular spread of preexisting benign uterine tumor tissue, and metastasized very low-grade uterine leiomyosarcoma have been proposed.
  • We described a case of pulmonary benign metastasizing leiomyoma associated with a uterine intravenous leiomyomatosis in a 46-year-old woman with a result of comparative genomic hybridization study.
  • Unresected pulmonary nodules were left untreated for 13 months after the hysterectomy and wedge biopsy of 3 pulmonary nodules to show no further growth, suggesting clinical behavior of nonmalignant tumor in our case.
  • Benign metastasizing leiomyomas may comprise a heterogeneous group of tumors in terms of their malignant potential and pathogenetic mechanism.
  • [MeSH-minor] DNA, Neoplasm. Female. Genomics. Humans. Middle Aged. Nucleic Acid Hybridization

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  • (PMID = 18580311.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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89. Laga AC, Tajirian AL, Islam MN, Bhattacharyya I, Cohen DM, Plamondon CJ, Robinson-Bostom L: Myopericytoma: report of two cases associated with trauma. J Cutan Pathol; 2008 Sep;35(9):866-70
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  • Myopericytoma is a rare, recently described tumor demonstrating a hemangiopericytoma-like vascular pattern.
  • Despite sharing morphologic features with angioleiomyoma, myofibroma and glomus tumor, myopericytoma is thought to represent a distinct perivascular myoid neoplasm of skin and soft tissues.
  • The tumor is characterized by a radial and perivascular arrangement of ovoid, spindled to round neoplastic cells that are immunoreactive to alpha-smooth muscle actin, often for h-caldesmon as well as smooth muscle myosin-heavy chain, and usually negative for desmin antibodies.
  • Most cases of myopericytoma are benign, however, local recurrence and malignancy have recently been reported, Myopericytoma can be multifocal involving a single or multiple anatomic regions, and tends to occur in dermal and superficial soft tissues of adults primarily on the extremities.
  • [MeSH-minor] Actins / metabolism. Aged. Biomarkers, Tumor / metabolism. Calcium-Binding Proteins / metabolism. Female. Humans. Male. Microfilament Proteins / metabolism. Middle Aged. Mouth Mucosa / injuries. Myosin Heavy Chains / metabolism. Nose / injuries. Treatment Outcome

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  • (PMID = 18494828.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Calcium-Binding Proteins; 0 / Microfilament Proteins; 0 / calponin; EC 3.6.4.1 / Myosin Heavy Chains
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90. Mikami Y, Kiyokawa T, Moriya T, Sasano H: Immunophenotypic alteration of the stromal component in minimal deviation adenocarcinoma ('adenoma malignum') and endocervical glandular hyperplasia: a study using oestrogen receptor and alpha-smooth muscle actin double immunostaining. Histopathology; 2005 Feb;46(2):130-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunophenotypic alteration of the stromal component in minimal deviation adenocarcinoma ('adenoma malignum') and endocervical glandular hyperplasia: a study using oestrogen receptor and alpha-smooth muscle actin double immunostaining.
  • AIMS: To define the phenotypic alteration of the stromal component in association with destructive invasion which is a crucial feature in distinguishing minimal deviation adenocarcinoma (MDA) from benign endocervical glandular lesions.
  • METHODS AND RESULTS: We studied endocervical glandular hyperplasias including non-specific-type (NEGH) (n = 3) and lobular-type (LEGH) (n = 8), and minimal deviation adenocarcinoma (MDA) (n = 11), well-differentiated endocervical adenocarcinoma of usual-type (WDA) (n = 11), and adenocarcinoma in situ (AIS) (n = 6) of the cervix, by double immunostaining for oestrogen receptor (ER) and alpha-smooth muscle actin (alpha-SMA) using peroxidase- and alkaline phosphatase-polymer methods, respectively.
  • [MeSH-minor] Female. Humans. Hyperplasia. Immunohistochemistry / methods. Metaplasia. Muscle, Smooth / chemistry. Neoplasm Invasiveness


91. Galajda Z, Copotoiu C, Suciu H, Tint D, Glasz T, Deac R: The diagnosis, morphological particularities, and surgical technique in a case of intravascular leiomyoma extended to the right heart chambers. J Vasc Surg; 2010 Apr;51(4):1000-2
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  • Intravenous leiomyoma is a benign smooth muscle cell tumor of uterine origin that may grow into the pelvic veins and the inferior vena cava.
  • Because cardiac involvement is present in up to 10% of cases, it may be misdiagnosed as a primary cardiac tumor or a venous thrombus-in-transit.
  • We describe a case of intravascular leiomyomatosis with cardiac extension and the morphological particularities of the removed tumor.
  • [MeSH-minor] Adult. Cardiac Surgical Procedures. Diagnostic Errors. Female. Heart Atria / pathology. Heart Atria / surgery. Heart Neoplasms / diagnosis. Heart Ventricles / pathology. Humans. Hysterectomy. Myxoma / diagnosis. Neoplasm Invasiveness. Ovariectomy. Treatment Outcome

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  • (PMID = 20045621.001).
  • [ISSN] 1097-6809
  • [Journal-full-title] Journal of vascular surgery
  • [ISO-abbreviation] J. Vasc. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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92. Bugalho A, Oliveira A, Semedo J, Lourenço I, Carreiro L: Argon-plasma treatment in benign metastasizing leiomyoma of the lung: a case report. Rev Port Pneumol; 2010 Nov-Dec;16(6):921-3; discussion 925
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  • [Title] Argon-plasma treatment in benign metastasizing leiomyoma of the lung: a case report.
  • Benign metastasizing leiomyomas of the lung are rare smooth muscle cells tumours.
  • Bronchial biopsy histological features were consistent with benign metastasizing leiomyoma.
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Metastasis

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  • (PMID = 21067700.001).
  • [ISSN] 2172-6825
  • [Journal-full-title] Revista portuguesa de pneumologia
  • [ISO-abbreviation] Rev Port Pneumol
  • [Language] eng; por
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Portugal
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93. Murtoniemi K, Pirinen E, Kähkönen M, Heiskanen N, Heinonen S: Smooth muscle tumor of the placenta - an entrapped maternal leiomyoma: a case report. J Med Case Rep; 2009;3:7302
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  • [Title] Smooth muscle tumor of the placenta - an entrapped maternal leiomyoma: a case report.
  • Tumors arising from the placental tissue include two distinct histological types: the benign vascular tumor, chorangioma, and very rarely, choriocarcinoma.
  • Benign leiomyomas, in contrast, are very common tumors of the uterine wall and occur in 0.1% to 12.5% of all pregnant women.
  • This case is possibly the first report on this kind of a placental tumor which has been examined using both immunohistochemistry and chromosome analysis.
  • Histologically, the tumor was a benign leiomyoma and this finding was supported by immunohistochemistry.
  • Chromosomes of the neoplasm were studied by the fluorescence in situ hybridization technique and the tumor was found to carry XX chromosomes.
  • CONCLUSION: A rare benign smooth muscle neoplasm involving the placental parenchyma is presented.
  • The tumor was a uterine leiomyoma of maternal origin, which had become entrapped by the placenta.

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  • [Cites] Indian J Pathol Microbiol. 2005 Apr;48(2):223-4 [16758675.001]
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  • (PMID = 19830174.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2726536
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94. Dao LN, Scheithauer BW, Erlandson RA, Young WF Jr, Aidan Carney J: Divergent myoid, neuroendocrine, and perineural differentiation in a nasal tumor of a patient with Carney complex. Am J Surg Pathol; 2008 Jan;32(1):167-71
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  • [Title] Divergent myoid, neuroendocrine, and perineural differentiation in a nasal tumor of a patient with Carney complex.
  • Computed tomography showed bilateral thalamic infarctions and also an unsuspected multicompartmental cystic neoplasm that had eroded the anterior clivus and extended forward into the nasopharynx.
  • Histologically, the mass appeared benign and was composed of spindle cells and multiple foci of striated muscle.
  • Immunohistochemically, the spindle cells were strongly reactive for S-100 protein and to a lesser extent for CD57, collagen IV, neuron-specific enolase, smooth muscle actin, epithelial membrane antigen, and glut-1.
  • The striated muscle cells were positive for desmin and myogenin.
  • Ultrastructurally, the spindle cells showed divergent differentiation along several cell lines, including smooth muscle, neuroendocrine, hybrid smooth muscle-neuroendocrine, perineural-like cells, and striated muscle.
  • [MeSH-major] Neoplasms, Muscle Tissue / ultrastructure. Neoplastic Syndromes, Hereditary / pathology. Nose Neoplasms / ultrastructure. Perineum / pathology


95. Nahal A, Meterissian S: Lipoleiomyosarcoma of the rectosigmoid colon: a unique site for a rare variant of liposarcoma. Am J Clin Oncol; 2009 Aug;32(4):353-5
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  • OBJECTIVES: Soft tissue tumors with dual adipocytic and smooth muscle differentiation are generally rare with most being benign.
  • Sarcomas with dual fatty and smooth muscle differentiation are even rarer.
  • [MeSH-major] Leiomyosarcoma / pathology. Liposarcoma / pathology. Neoplasm Invasiveness / pathology. Rectal Neoplasms / pathology. Sigmoid Neoplasms / pathology
  • [MeSH-minor] Biopsy, Needle. Colectomy / methods. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. Laparotomy / methods. Middle Aged. Neoplasm Staging. Pelvic Pain / diagnosis. Pelvic Pain / etiology. Radiotherapy, Adjuvant. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19363435.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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96. Kim HJ, Kim CH, Choi YJ, Ayala AG, Amirikachi M, Ro JY: Juxtaglomerular cell tumor of kidney with CD34 and CD117 immunoreactivity: report of 5 cases. Arch Pathol Lab Med; 2006 May;130(5):707-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Juxtaglomerular cell tumor of kidney with CD34 and CD117 immunoreactivity: report of 5 cases.
  • CONTEXT: Juxtaglomerular cell tumor is a rare renal neoplasm.
  • Renin immunohistochemistry and electron microscopic documentation of rhomboid crystals are the primary methods of diagnosing this benign tumor.
  • OBJECTIVES: In this retrospective study, we evaluated the morphologic, immunohistochemical, and ultrastructural features of 5 cases of juxtaglomerular cell tumor to determine the effectiveness of CD34 and CD117 immunohistochemistry for the diagnosis of this tumor.
  • On light microscopic examination, we found solid sheets and nests of tumor cells with oval-to-round nuclei and eosinophilic cytoplasm.
  • Immunohistochemistry results were as follows: vimentin (positive), renin (weakly positive), smooth muscle actin (focal immunoreactivity), and cytokeratin (negative).
  • CONCLUSIONS: Our findings indicate that immunohistochemistry for CD34 and CD117 are effective at diagnosing juxtaglomerular cell tumor.
  • Juxtaglomerular cell tumor should be considered in the diagnosis of any renal tumors with epithelioid cells and negative initial cytokeratin immunohistochemistry.
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Female. Humans. Hypertension / diagnosis. Male. Middle Aged. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16683889.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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97. Angiero F: Ectomesenchymal chondromyxoid tumour of the tongue. A review of histological and immunohistochemical features. Anticancer Res; 2010 Nov;30(11):4685-9
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  • BACKGROUND: Ectomesenchymal chondromyxoid tumour (ECT) is a rare, benign neoplasm of uncertain histogenesis, which appears to exclusively involve the oral cavity, particularly the tongue.
  • Immunohistochemistry revealed positivity of the neoplastic cells for antibodies directed against S-100, glial fibrillary acidic protein and vimentin, plus negativity for CD-57(leu-7), epithelial membrane antigen, smooth muscle actin, desmin and cytokeratin AE1-AE3.

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  • (PMID = 21115924.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Desmin; 0 / Glial Fibrillary Acidic Protein; 0 / S100 Proteins; 0 / Vimentin
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98. Man YG, Nieburgs HE: A subset of cell clusters with malignant features in morphologically normal-appearing and hyperplastic tissues. Cancer Detect Prev; 2006;30(3):239-47
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  • (1) a significantly increased frequency of focal disruptions in surrounding myoepithelial cell layers and the loss of estrogen receptor expression, (2) signs of stromal and vascular invasion, (3) distinct alterations in the cytoplasmic-nuclear ratio and nuclear shape, size, and polarity, (4) the expression of multiple malignancy-associated biomarkers, and (5) malignancy-associated nuclear changes in benign-appearing cells.
  • CONCLUSIONS: These changes are likely to reflect DNA structural abnormalities resulting from the disposition of DNA and RNA structural defects or cancer susceptibility genes that facilitate progression and invasion, or to suggest that breast tumor progression and invasion may not always follow the hypothesized sequences.
  • [MeSH-minor] Actins / metabolism. Cell Nucleus / metabolism. Cytoplasm / metabolism. DNA / metabolism. Epithelial Cells / metabolism. Humans. Immunohistochemistry. Muscle, Smooth / metabolism. Neoplasm Invasiveness. RNA / metabolism. Receptors, Estrogen / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 16872754.001).
  • [ISSN] 0361-090X
  • [Journal-full-title] Cancer detection and prevention
  • [ISO-abbreviation] Cancer Detect. Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Actins; 0 / Receptors, Estrogen; 0 / Tumor Suppressor Protein p53; 63231-63-0 / RNA; 9007-49-2 / DNA
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99. Nucci MR, Harburger D, Koontz J, Dal Cin P, Sklar J: Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms. Am J Surg Pathol; 2007 Jan;31(1):65-70
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  • In addition, we examined 4 cases of highly cellular leiomyoma, a benign morphologic mimic of LGESS.
  • Our data suggest that the JAZF1-JJAZ1 fusion is a frequent, although nonuniform, feature of endometrial stromal neoplasia, irrespective of benign versus malignant classification and smooth muscle differentiation.
  • [MeSH-major] Endometrial Stromal Tumors / genetics. Gene Fusion. Neoplasm Proteins / genetics. Sarcoma, Endometrial Stromal / genetics. Transcription Factors / genetics

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  • (PMID = 17197920.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / JAZF1 protein, human; 0 / JJAZ1 protein, human; 0 / Neoplasm Proteins; 0 / Transcription Factors
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100. Meenakshi M, McCluggage WG: Myoepithelial neoplasms involving the vulva and vagina: report of 4 cases. Hum Pathol; 2009 Dec;40(12):1747-53
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  • In all cases, the tumor cells were positive for epithelial markers (cytokeratins and/or epithelial membrane antigen) and the myoid markers alpha smooth muscle actin and calponin.
  • On the basis of the nuclear features and degree of mitotic activity, 2 neoplasms were classified as benign myoepitheliomas and 2 as myoepithelial carcinomas.
  • As far as we are aware, this is the first description of a primary vaginal myoepithelial neoplasm.
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged

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  • (PMID = 19716162.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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