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1. Pérez de la Fuente T, Vega C, Gutierrez Palacios A, Sanchez Lorenzo J, Gonzalez Sarasua J: Glomangiosarcoma of the hypothenar eminence: a case report. Chir Main; 2005 Jun-Aug;24(3-4):199-202
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  • Glomangiosarcoma is an exceptionally rare soft tissue tumor.
  • There are only two cases described on the hand before instead of the benign glomus tumor is usually located at this level.
  • Histochemically the glomangiosarcoma shows features that remind a benign glomus tumor, except for the malignant glomus tumor arising de novo.
  • This neoplasm is considered a low grade malignant tumor with tendency to local recurrence, though metastasis have been reported.
  • We report the case of a 36 year-old -woman with a glomangiosarcoma in a glomus tumor in the hypotenar eminence.
  • [MeSH-major] Glomus Tumor / pathology. Hand / surgery. Skin Neoplasms / pathology

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  • (PMID = 16121631.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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2. Mathew RA, Schlauder SM, Calder KB, Morgan MB: CD117 immunoreactivity in atypical fibroxanthoma. Am J Dermatopathol; 2008 Feb;30(1):34-6
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  • Atypical fibroxanthoma (AFX) is a spindle cell neoplasm of the skin seen typically on sun-damaged skin of the elderly.
  • Though described as a benign entity, local recurrence and distant metastasis have been reported.
  • The percentage of positive cells for CD117 expression among all tumors was approximately 30%.
  • [MeSH-major] Biomarkers, Tumor / analysis. Histiocytoma, Benign Fibrous / metabolism. Proto-Oncogene Proteins c-kit / biosynthesis. Skin Neoplasms / metabolism

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  • [CommentIn] Am J Dermatopathol. 2008 Aug;30(4):401-2 [18645317.001]
  • [CommentIn] Am J Dermatopathol. 2009 Feb;31(1):96-8 [19155737.001]
  • [CommentIn] Am J Dermatopathol. 2008 Dec;30(6):640-2 [19033951.001]
  • (PMID = 18212542.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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3. Fauth CT, Bruecks AK, Temple W, Arlette JP, DiFrancesco LM: Superficial leiomyosarcoma: a clinicopathologic review and update. J Cutan Pathol; 2010 Feb;37(2):269-76
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  • Fourteen tumors were confined to the dermis and 11 involved subcutaneous tissue.
  • Novel histological features included epidermal hyperplasia, sclerotic collagen bands and increasing tumor grade with the depth of the lesion.
  • CONCLUSIONS: SLMSs are rare but important smooth muscle tumors of the skin.
  • The clinical presentation may be non-specific.
  • SLMS can appear low grade or even benign on superficial biopsies, leading to undergrading or a delay in the correct diagnosis.
  • [MeSH-major] Leiomyosarcoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Proteins / metabolism. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Treatment Outcome

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  • (PMID = 19694881.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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4. Temam F, Bizuneh E, Leekassa R: Disseminated form of syringoma (eruptive syringoma) sparing the face-a rare presentation causing diagnostic challenge. Ethiop Med J; 2008 Jul;46(3):273-6
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  • Syringomas are benign neoplasms of the skin commonly appearing around the eye lids.
  • The lesions are asymptomatic, firm, discrete, translucent or skin colored flat-topped papules.
  • [MeSH-major] Sweat Gland Neoplasms / pathology. Syringoma / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 19271392.001).
  • [ISSN] 0014-1755
  • [Journal-full-title] Ethiopian medical journal
  • [ISO-abbreviation] Ethiop. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ethiopia
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5. Borenstein M, Mirzabeigi M, Vincek V: Pityrosporum and seborrheic keratosis: an association. Dermatol Online J; 2005;11(2):3
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  • Seborrheic keratoses (SK) are one of the most common benign tumors of the skin.
  • Studies have suggested that human papillomavirus or a benign clonal proliferation of epidermal cells is involved in the pathogenesis of some SK's, however, this issue remains to be resolved.

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  • (PMID = 16150211.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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6. Leow LJ, Sinclair PA, Horton JJ: Plaque-like dermatofibroma: A distinct and rare benign neoplasm? Australas J Dermatol; 2008 May;49(2):106-8
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  • [Title] Plaque-like dermatofibroma: A distinct and rare benign neoplasm?
  • Based on the histological findings, a diagnosis of dermatofibroma was made for each of these cases.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin / pathology. Skin Neoplasms / pathology

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  • (PMID = 18412813.001).
  • [ISSN] 1440-0960
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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7. Scope A, Tabanelli M, Busam KJ, Rabinovitz H, Braun RP, Marghoob AA: Dispelling the myth of the "benign hair sign" for melanoma. J Am Acad Dermatol; 2007 Mar;56(3):413-6
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  • [Title] Dispelling the myth of the "benign hair sign" for melanoma.
  • The vast majority of melanocytic lesions with hair, such as congenital melanocytic nevi, are benign.
  • However, there is a notion that the presence of one or more hairs in a melanocytic lesion is confirmatory for the benign nature of the lesion.
  • To dispel this notion, we present 3 examples of melanocytic lesions that showed terminal hairs on clinical and dermoscopic evaluation, but in which the final diagnosis was invasive melanoma.
  • Thus, integrating all clinical and dermoscopic findings, rather than relying on a single criterion for the lesion at hand should guide clinicians to the correct diagnosis.
  • [MeSH-major] Hair / pathology. Melanoma / pathology. Neoplasm Invasiveness. Skin Neoplasms / pathology

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  • (PMID = 17156892.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Lee J: Epithelioid cell histiocytoma with granular cells (another nonneural granular cell neoplasm). Am J Dermatopathol; 2007 Oct;29(5):475-6
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  • [Title] Epithelioid cell histiocytoma with granular cells (another nonneural granular cell neoplasm).
  • [MeSH-major] Granular Cell Tumor / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Antigens, CD / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Cytoplasmic Granules / pathology. Factor XIIIa / metabolism. Humans. Male. Middle Aged. Skin / metabolism. Skin / pathology. Vimentin / metabolism

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  • (PMID = 17890918.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / Vimentin; EC 2.3.2.13 / Factor XIIIa
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9. Sookhan N, Boughey JC, Walsh MF, Degnim AC: Nipple-sparing mastectomy--initial experience at a tertiary center. Am J Surg; 2008 Oct;196(4):575-7
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  • BACKGROUND: Nipple-sparing mastectomy (NSM) combines skin-sparing mastectomy with preservation of the nipple-areolar dermis and intraoperative pathologic assessment of the nipple core.
  • The average distance of tumor from the nipple on imaging was 4.8 cm (range 4 to 5.7).
  • Nipple cores were all benign, and 2 patients developed self-limited superficial desquamation of the nipple.
  • [MeSH-major] Breast Neoplasms / surgery. Mammaplasty / methods. Mastectomy / methods. Nipples / surgery
  • [MeSH-minor] Adult. Body Image. Esthetics. Female. Humans. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Treatment Outcome


10. Brailey LL, Davis T, Kolker SE, Murry TC, Thomas D, Bale AE, Ruhoy SM: Congenital linear unilateral basal cell nevus: a case report with patched gene molecular studies. J Cutan Pathol; 2007 Jan;34(1):65-70
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  • BACKGROUND: Linear unilateral basal cell nevus represents a linear collection of macules and papules histologically similar to basal cell carcinoma but with benign clinical behavior.
  • The differential diagnosis included the nevoid basal cell carcinoma syndrome.
  • [MeSH-major] Nevus / genetics. Nevus / pathology. Skin Neoplasms / genetics. Skin Neoplasms / pathology. Thigh
  • [MeSH-minor] DNA, Neoplasm. Diagnosis, Differential. Humans. Infant. Loss of Heterozygosity. Microsatellite Repeats. Mutation. Receptors, Cell Surface / genetics. Receptors, G-Protein-Coupled / genetics

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  • (PMID = 17214858.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Receptors, Cell Surface; 0 / Receptors, G-Protein-Coupled; 0 / SMO protein, human; 0 / patched receptors
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11. Torrijos-Aguilar A, Alegre-de Miquel V, Pitarch-Bort G, Mercader-García P, Fortea-Baixauli JM: [Cutaneous granular cell tumor: a clinical and pathologic analysis of 34 cases]. Actas Dermosifiliogr; 2009 Mar;100(2):126-32
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  • [Title] [Cutaneous granular cell tumor: a clinical and pathologic analysis of 34 cases].
  • [Transliterated title] Tumor de células granulares cutáneo: análisis clínico-patológico de treinta y cuatro casos.
  • BACKGROUND: Granular cell tumor (GCT), also known as Abrikossoff tumor, is an uncommon benign neoplasm, probably of neural origin derived from Schwann cells.
  • OBJECTIVES: We aimed to analyze the clinical, histologic, and immunohistochemical characteristics associated with this tumor and to determine whether these findings correspond to those reported to date in the literature.
  • METHODS: In this retrospective study of 34 patients with histologic diagnosis of GCT, we analyzed clinical characteristics (site, age, sex, duration, and suspected diagnosis), histological findings (border, cell atypia and mitoses, involvement of adnexal structures, pseudoepitheliomatous hyperplasia, and presence of the recently described pustulo-ovoid bodies), and immunohistochemical findings (S-100 staining in 16 randomly selected cases).
  • The most common site was the oral cavity (61.76 %).
  • The most frequently suspected clinical diagnosis was fibroma (17.65 %).
  • CONCLUSIONS: Our series confirms the characteristics described previously for GCT, except for certain peculiarities, and supports the presence of pustulo-ovoid bodies as an additional histologic finding for diagnosis of this tumor.
  • [MeSH-major] Granular Cell Tumor / epidemiology. Mouth Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor. Child. Child, Preschool. Cytoplasmic Granules / ultrastructure. Diagnosis, Differential. Female. Fibroma / diagnosis. Humans. Male. Middle Aged. Retrospective Studies. Skin Neoplasms / chemistry. Skin Neoplasms / diagnosis. Skin Neoplasms / epidemiology. Skin Neoplasms / pathology. Staining and Labeling. Young Adult

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  • (PMID = 19445877.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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12. Hafner C, Di Martino E, Pitt E, Stempfl T, Tomlinson D, Hartmann A, Landthaler M, Knowles M, Vogt T: FGFR3 mutation affects cell growth, apoptosis and attachment in keratinocytes. Exp Cell Res; 2010 Jul 15;316(12):2008-16
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  • FGFR3 mutations have recently been identified in several benign epidermal skin lesions such as seborrheic keratosis, epidermal nevus and solar lentigo.
  • The functional consequences of these mutations in human skin are as yet unknown.
  • In this study we analyzed the functional effects of the most common FGFR3 mutation in benign skin tumors, the R248C FGFR3 hotspot mutation, in human HaCaT keratinocytes.
  • Our results suggest that an increased cell number at confluence along with a decreased apoptosis may contribute to the development of acanthotic tumors in FGFR3 mutant skin in vivo.

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  • (PMID = 20420824.001).
  • [ISSN] 1090-2422
  • [Journal-full-title] Experimental cell research
  • [ISO-abbreviation] Exp. Cell Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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13. Tatiana K S C, Somers GR, Pope E, Zuker RM: Predisposing factors and outcomes of malignant skin tumors in children. Plast Reconstr Surg; 2010 Aug;126(2):508-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Predisposing factors and outcomes of malignant skin tumors in children.
  • BACKGROUND: Although benign and metastatic tumors occur in children, primary malignant skin tumors are uncommon in the pediatric population.
  • In this study, the authors aimed to determine the incidence, risk factors, treatment, reconstruction details, and outcome of malignant skin tumors occurring in pediatric patients at the Hospital for Sick Children.
  • METHODS: The electronic database (CoPath) of the pathology department was searched for all cases of malignant skin tumors treated surgically between January of 2000 and September of 2008.
  • RESULTS: Eighteen patients had been diagnosed and treated surgically for malignant skin tumors.
  • Diagnosis of malignant melanoma was made in 14 patients, diagnosis of basal cell carcinoma was made in four patients, and diagnosis of squamous cell carcinoma was made in one patient.
  • All cases of basal cell carcinoma and squamous cell carcinoma underwent surgical resection and primary closure or skin graft.
  • Of the patients with malignant melanoma, seven underwent surgical excision and primary closure and five had excision and skin graft.
  • CONCLUSIONS: Malignant skin tumors are rare in children.
  • In accordance with previously published data, malignant melanoma was the most frequent tumor in our study.
  • Epithelial tumors were less common and were all associated with an underlying predisposing condition.
  • [MeSH-major] Neoplasm Recurrence, Local / pathology. Sentinel Lymph Node Biopsy / methods. Skin Neoplasms / epidemiology. Skin Neoplasms / surgery. Skin Transplantation / methods
  • [MeSH-minor] Adolescent. Age Distribution. Canada / epidemiology. Carcinoma, Basal Cell / epidemiology. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Causality. Child. Child, Preschool. Cohort Studies. Databases, Factual. Dermatology / methods. Female. Follow-Up Studies. Humans. Immunohistochemistry. Incidence. Male. Melanoma / epidemiology. Melanoma / pathology. Melanoma / surgery. Neoplasm Staging. Sex Distribution. Survival Rate. Treatment Outcome

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  • (PMID = 20375763.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Tran TA, Hayner-Buchan A, Jones DM, McRorie D, Carlson JA: Cutaneous balloon cell dermatofibroma (fibrous histiocytoma). Am J Dermatopathol; 2007 Apr;29(2):197-200
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  • [Title] Cutaneous balloon cell dermatofibroma (fibrous histiocytoma).
  • Dermatofibroma (DF) or cutaneous fibrous histiocytoma is a common benign skin tumor that exhibits multiple, distinct histologic variants.
  • Excisional biopsy revealed a circumscribed fibrous tumor populated by mostly clear and spindle cells.
  • A zonal arrangement separated the varied tumor cells where the most superficial, polypoid area showed large, clear polygonal balloon cells; the mid-dermal zone demonstrated a transition between balloon cells, epithelioid cells, and spindle cells; and the deep dermal zone had storiform arrangement of spindle cells, with the fascicles separated by coarse collagen bundles.
  • Ultrastructurally, the clear tumor cells were filled with multiple, empty, nonmembrane bound vacuoles of varying size.
  • DF with balloon cell change, likely secondary to persistent irritation, should be added to the differential diagnosis of cutaneous primary and metastatic neoplasms showing balloon cell degeneration such as balloon cell melanocytic nevi and renal cell carcinoma, respectively.
  • [MeSH-major] Heel. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Diagnosis, Differential. Factor XIIIa / analysis. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission. Neprilysin / analysis. Time Factors. Treatment Outcome. Vacuoles / ultrastructure

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  • (PMID = 17414448.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; EC 2.3.2.13 / Factor XIIIa; EC 3.4.24.11 / Neprilysin
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15. Goodson AG, Florell SR, Boucher KM, Grossman D: Low rates of clinical recurrence after biopsy of benign to moderately dysplastic melanocytic nevi. J Am Acad Dermatol; 2010 Apr;62(4):591-6
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  • [Title] Low rates of clinical recurrence after biopsy of benign to moderately dysplastic melanocytic nevi.
  • Of 61 benign nevus biopsy sites examined, clinical recurrence was observed in two (3.3%).
  • CONCLUSION: In this cohort, rates of clinical recurrence after biopsy of DN and benign nevi were extremely low.

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  • [Copyright] Copyright 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
  • [Cites] Arch Dermatol. 2003 Oct;139(10):1374-5 [14568850.001]
  • [Cites] Arch Dermatol. 2003 Mar;139(3):282-8 [12622618.001]
  • [Cites] Arch Dermatol. 2003 Dec;139(12):1620-4; discussion 1624 [14676081.001]
  • [Cites] J Cutan Pathol. 2004 Sep;31(8):523-30 [15268706.001]
  • [Cites] J Clin Pathol. 2004 Nov;57(11):1121-31 [15509670.001]
  • [Cites] Arch Dermatol. 1975 Dec;111(12):1588-90 [1200664.001]
  • [Cites] J Am Acad Dermatol. 1987 Sep;17(3):459-68 [3655025.001]
  • [Cites] Australas J Dermatol. 1990;31(2):77-80 [2095738.001]
  • [Cites] JAMA. 1992 Sep 9;268(10):1314-9 [1507379.001]
  • [Cites] Br J Cancer. 1996 Jun;73(12):1605-11 [8664138.001]
  • [Cites] JAMA. 1997 May 14;277(18):1439-44 [9145715.001]
  • [Cites] Med J Aust. 1997 Aug 18;167(4):191-4 [9293264.001]
  • [Cites] Dermatol Surg. 2005 Sep;31(9 Pt 1):1112-5 [16164859.001]
  • [Cites] Semin Oncol. 2007 Dec;34(6):467-75 [18083370.001]
  • [Cites] J Am Acad Dermatol. 2008 Nov;59(5):814-21 [19119097.001]
  • [Cites] South Med J. 2009 Jan;102(1):45-8 [19077745.001]
  • [Cites] Cancer Biol Ther. 2008 Nov;7(11):1706-11 [18836285.001]
  • [Cites] Dermatol Surg. 2000 Jul;26(7):662-6 [10886275.001]
  • [Cites] Hautarzt. 2000 Aug;51(8):575-80 [10997312.001]
  • [Cites] J Pathol. 2002 Apr;196(4):459-66 [11920743.001]
  • [Cites] Dermatol Surg. 2003 Mar;29(3):227-9 [12614413.001]
  • [Cites] N Engl J Med. 2003 Dec 4;349(23):2233-40 [14657431.001]
  • (PMID = 20018406.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] ENG
  • [Grant] United States / NIAMS NIH HHS / AR / AR050102-05; United States / NIAMS NIH HHS / AR / R01 AR050102; United States / NIAMS NIH HHS / AR / R01 AR050102-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS204974; NLM/ PMC2886801
  • [Keywords] NOTNLM ; biopsy / dysplastic / nevi / recurrence
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16. Jiang W, Fujii H, Matsumoto T, Ohtsuji N, Tsurumaru M, Hino O: Birt-Hogg-Dubé (BHD) gene mutations in human gastric cancer with high frequency microsatellite instability. Cancer Lett; 2007 Apr 8;248(1):103-11
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  • Birt-Hogg-Dubé (BHD) syndrome is a rare inherited genodermatosis characterized by benign hamartomatous skin lesions and an increased risk of pneumothorax and renal tumors.
  • This mutational hot spot is also reported to be a target of mutation in microsatellite instability (MSI) sporadic colorectal tumors.
  • [MeSH-major] Microsatellite Instability. Mutation. Proteins / genetics. Proto-Oncogene Proteins / genetics. Stomach Neoplasms / pathology. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Base Sequence. DNA Mutational Analysis. Exons / genetics. Female. Gene Frequency. Humans. Male. Middle Aged. Neoplasm Staging. Poly C / genetics. Protein-Serine-Threonine Kinases. Receptors, Transforming Growth Factor beta / genetics. bcl-2-Associated X Protein / genetics

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  • (PMID = 16870330.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / BAX protein, human; 0 / FLCN protein, human; 0 / Proteins; 0 / Proto-Oncogene Proteins; 0 / Receptors, Transforming Growth Factor beta; 0 / Tumor Suppressor Proteins; 0 / bcl-2-Associated X Protein; 30811-80-4 / Poly C; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.30 / transforming growth factor-beta type II receptor
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17. Benbenisty KM, Andea A, Metcalf J, Cook J: Atypical cellular neurothekeoma treated with Mohs micrographic surgery. Dermatol Surg; 2006 Apr;32(4):582-7; discussion 587
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  • BACKGROUND: Atypical cellular neurothekeoma is a rare neoplasm generally regarded as a benign tumor with locally aggressive behavior.
  • RESULTS: The neoplasm was extirpated in a three-stage, five section Mohs surgery procedure.
  • CONCLUSION: Mohs micrographic surgery is unsurpassed in its efficacy in treating a wide variety of nonmelanoma skin cancers.
  • Although most commonly used to address basal and squamous cell carcinoma, it has also been reported as a successful treatment for melanoma and a wide variety of cutaneous malignancies.
  • Debate in the literature is ongoing regarding the true histogenesis of this rare tumor.
  • Because of this tumor's local destructive behavior and propensity to recur with inadequate resection, we recommend Moths micrographic surgery for the treatment of cellular neurothekeomas.
  • [MeSH-major] Mohs Surgery. Neurothekeoma / surgery. Nose Neoplasms / surgery

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  • [CommentIn] Dermatol Surg. 2008 Mar;34(3):428 [18248473.001]
  • (PMID = 16681671.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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18. Wu J, Rosenbaum E, Begum S, Westra WH: Distribution of BRAF T1799A(V600E) mutations across various types of benign nevi: implications for melanocytic tumorigenesis. Am J Dermatopathol; 2007 Dec;29(6):534-7
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  • [Title] Distribution of BRAF T1799A(V600E) mutations across various types of benign nevi: implications for melanocytic tumorigenesis.
  • The nevi were inclusive of congenital (n = 34) and acquired (n = 101) nevi, dysplastic (n = 11) and nondysplastic (n = 124) nevi, and anogenital (n = 24) and common cutaneous (n = 111) nevi.
  • The rate varied only slightly by anatomic site: BRAF mutations were detected in 21 of 21 (100%) nevi of the head and neck, 62 of 76 (82%) nevi of the trunk, 8 of 14 (62%) nevi of the extremities, and 18 of 24 (75%) anogenital nevi.
  • For acquired nevi, there was no association between BRAF mutations and sun exposure as inferred from anatomic site.
  • [MeSH-major] Melanocytes / pathology. Mutation. Nevus / genetics. Proto-Oncogene Proteins B-raf / genetics. Skin Neoplasms / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Anus Neoplasms / genetics. Anus Neoplasms / pathology. Anus Neoplasms / surgery. Back / pathology. Child. DNA Mutational Analysis. DNA, Neoplasm / analysis. Extremities / pathology. Female. Head and Neck Neoplasms / genetics. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / surgery. Humans. Male. Microdissection. Middle Aged. Urogenital Neoplasms / genetics. Urogenital Neoplasms / pathology. Urogenital Neoplasms / surgery

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  • (PMID = 18032947.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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19. Gray RJ, Pockaj BA, Vega ML, Connolly SM, DiCaudo DJ, Kile TA, Buchel EW: Diagnosis and treatment of malignant melanoma of the foot. Foot Ankle Int; 2006 Sep;27(9):696-705
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  • [Title] Diagnosis and treatment of malignant melanoma of the foot.
  • METHODS: A retrospective review was performed of 38 patients with a diagnosis of primary or locally recurrent melanoma of the foot treated between January, 1988, and July, 2004.
  • The main outcome measures included methods of diagnosis, clinical and histopathologic features, and patterns of recurrence.
  • RESULTS: The mean age at diagnosis was 61 years; most were women (58%) and Caucasian (95%).
  • The average time to diagnosis was 17 months.
  • Initial clinical diagnosis had been considered benign in 12 (32%).
  • Surgical complications occurred in 12 patients, usually after skin graft or soft-tissue flap reconstruction.
  • CONCLUSIONS: Most patients were elderly Caucasian women and most presented with early-stage disease, but diagnosis can be difficult and a subgroup presented with thick melanomas.
  • Stage of cancer at diagnosis was associated with systemic metastases.
  • [MeSH-major] Foot Diseases / diagnosis. Foot Diseases / surgery. Melanoma / diagnosis. Melanoma / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Postoperative Complications. Retrospective Studies. Time Factors. Treatment Outcome

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  • (PMID = 17038281.001).
  • [ISSN] 1071-1007
  • [Journal-full-title] Foot & ankle international
  • [ISO-abbreviation] Foot Ankle Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Mühlhoff C, Krenkel B, Rübben A, Megahed M: [Pagetoid reticulosis in a patient with mycosis fungoides. Successful therapy with localized electron beam irradiation]. Hautarzt; 2010 May;61(5):378-82
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  • It is characterized by a prominent epidermotropism, localized lesions, slow progression and benign prognosis.
  • [MeSH-major] Foot Diseases / radiotherapy. Mycosis Fungoides / radiotherapy. Neoplasm Recurrence, Local / radiotherapy. Neoplasms, Multiple Primary / radiotherapy. Pagetoid Reticulosis / radiotherapy. Skin Neoplasms / radiotherapy
  • [MeSH-minor] Aged. Biopsy. Combined Modality Therapy. Electrons / therapeutic use. Follow-Up Studies. Heel. Humans. Male. Skin / pathology

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  • [Cites] Onkologie. 2003 Aug;26(4):366-72 [12972705.001]
  • [Cites] Br J Dermatol. 2005 Nov;153(5):874-80 [16225594.001]
  • [Cites] Br J Dermatol. 2002 Oct;147(4):806 [12366436.001]
  • [Cites] Blood. 2009 Nov 12;114(20):4337-53 [19696197.001]
  • [Cites] Mod Pathol. 2000 May;13(5):502-10 [10824921.001]
  • [Cites] Am J Dermatopathol. 1983 Apr;5(2):153-8 [6881481.001]
  • [Cites] Am J Dermatopathol. 2010 Feb;32(1):79-82 [19940753.001]
  • [Cites] Hautarzt. 2003 Mar;54(3):256-64 [12634995.001]
  • [Cites] Hautarzt. 1973 Jan;24(1):11-21 [4697319.001]
  • (PMID = 20401455.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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21. Charles CA, Yee VS, Dusza SW, Marghoob AA, Oliveria SA, Kopf A, Rigel D, Halpern AC: Variation in the diagnosis, treatment, and management of melanoma in situ: a survey of US dermatologists. Arch Dermatol; 2005 Jun;141(6):723-9
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  • [Title] Variation in the diagnosis, treatment, and management of melanoma in situ: a survey of US dermatologists.
  • OBJECTIVE: To assess current practices of US dermatologists regarding the diagnosis, treatment, and management of melanoma in situ (MIS).
  • Although most respondents would not unquestioningly accept a benign pathology diagnosis when there was a clinical suspicion of MIS, 16.1% would accept a pathologist's diagnosis without further action.
  • [MeSH-major] Dermatology / statistics & numerical data. Hutchinson's Melanotic Freckle / pathology. Hutchinson's Melanotic Freckle / therapy. Neoplasm Invasiveness / pathology. Practice Patterns, Physicians' / standards. Skin Neoplasms / pathology. Skin Neoplasms / therapy

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  • (PMID = 15967918.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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22. Craig S, Bui-Mansfield LT, Lusk JD: Radiology pathology conference of Brooke Army Medical Center: trichoblastoma of breast. Clin Imaging; 2009 Jul-Aug;33(4):311-3
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  • The differential diagnosis of a superficial breast lesion detected on mammography typically includes seborrheic keratosis, dermal nevus, epidermal inclusion cyst, and basal cell carcinoma with subcutaneous invasion [Kopans DB.
  • Trichoblastoma is a benign skin neoplasm that is rarely found in the breast.
  • [MeSH-major] Breast Neoplasms / diagnosis. Mammography / methods

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  • (PMID = 19559355.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Plaza JA, Torres-Cabala C, Evans H, Diwan HA, Suster S, Prieto VG: Cutaneous metastases of malignant melanoma: a clinicopathologic study of 192 cases with emphasis on the morphologic spectrum. Am J Dermatopathol; 2010 Apr;32(2):129-36
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  • [Title] Cutaneous metastases of malignant melanoma: a clinicopathologic study of 192 cases with emphasis on the morphologic spectrum.
  • Metastatic melanoma represents one of the most common types of cutaneous metastases.
  • For the most part, the histologic diagnosis of metastatic melanoma poses little diagnostic difficulty; however, some metastases may adopt unusual or unfamiliar appearances mimicking other benign and malignant conditions.
  • We present a study of 192 cases of cutaneous metastatic melanomas with special emphasis on their spectrum of morphologic features.
  • Most tumors were located on the proximal legs, scalp, and arms and ranged from 0.8 to 3.0 cm.
  • One hundred ten cases showed the classic morphologic appearance of melanoma (well-circumscribed epithelioid dermal/subcutaneous nodule), 82 cases showed unusual histologic appearances that mimicked other benign and malignant neoplasms.
  • In 16 patients (8.3%), there was no evidence of primary melanoma and the cutaneous metastasis was the only manifestation of the disease.
  • The histologic diagnosis of cutaneous metastatic melanoma can pose difficulties for diagnosis, especially in the face of an unknown primary neoplasm.
  • Unusual features observed in this series included examples of cutaneous metastatic melanoma that closely simulated metastatic carcinoma, dermatofibroma, leiomyosarcoma, angiosarcoma, nevoid melanoma, halo nevus, blue nevi, and atypical fibroxanthoma.
  • Immunohistochemical stains plus careful clinical history helped to establish the correct diagnosis.
  • Our series illustrates that the differential diagnosis of cutaneous metastatic melanoma can be broad and difficult.
  • To the best of our knowledge, this is the largest series of cutaneous metastatic melanomas reported in the literature.
  • [MeSH-major] Melanoma / secondary. Neoplasms, Unknown Primary. Skin / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, CD / metabolism. Antigens, CD34 / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Antigens, Neoplasm / metabolism. Desmin / metabolism. Diagnosis, Differential. Female. Humans. Ki-67 Antigen / metabolism. Male. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / metabolism

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  • (PMID = 20010406.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Antigens, Neoplasm; 0 / CD68 antigen, human; 0 / Desmin; 0 / Ki-67 Antigen; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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24. Sarma DP, Stevens T: Infiltrating syringomatous eccrine adenoma of the nipple: a case report. Cases J; 2009;2:9118
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  • BACKGROUND: Differential diagnosis for a nodule in the nipple or subareolar area of woman includes both primary neoplasms of breast as well as those from skin and adnexae.
  • A biopsy revealed an infiltrating adnexal neoplasm with features similar to those seen in syringomas commonly occurring in locations such as upper face and pubis.
  • Microscopic appearance of such a rare benign infiltrating neoplasm of eccrine duct origin occurring in woman's breast should not be misinterpreted as more common infiltrating primary breast carcinoma.
  • CONCLUSION: Infiltrating eccrine syringomatous adenoma should be included in the differential diagnosis of a nipple or subareolar nodule occurring in woman.

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  • [Cites] Surg Gynecol Obstet. 1966 Jun;122(6):1289-94 [5941852.001]
  • [Cites] Breast J. 2004 Sep-Oct;10(5):443-7 [15327500.001]
  • [Cites] Am J Surg Pathol. 1983 Dec;7(8):739-45 [6660349.001]
  • [Cites] Clin Radiol. 1993 Jan;47(1):62-4 [8381340.001]
  • [Cites] Arch Pathol Lab Med. 2003 Mar;127(3):e155-6 [12653606.001]
  • (PMID = 20062695.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803915
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25. Fleming DM, Cross KW, Barley MA: Recent changes in the prevalence of diseases presenting for health care. Br J Gen Pract; 2005 Aug;55(517):589-95
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  • Age-standardised prevalence rates per 10,000 registered persons and 99% confidence intervals (CIs) were calculated using the national census population for 2001 as the standard.
  • Survey differences in prevalence were identified from non-overlapping CIs.
  • The prevalence of mental disorders, skin disease and musculoskeletal disorders showed little change.
  • Particular increases were noted for other malignant and benign neoplasms of the skin, hypothyroidism and diabetes.

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  • [Cites] BMJ. 2003 Jun 28;326(7404):1439-43 [12829558.001]
  • [Cites] BMJ. 2002 Dec 14;325(7377):1397-8 [12480857.001]
  • [Cites] Arch Dis Child. 2004 Mar;89(3):282-5 [14977715.001]
  • [Cites] Eur J Public Health. 2004 Mar;14(1):10-4 [15080383.001]
  • [Cites] J Epidemiol Community Health. 1991 Sep;45(3):180-3 [1757757.001]
  • [Cites] BMJ. 1998 May 23;316(7144):1572-6 [9596597.001]
  • [Cites] Commun Dis Rep CDR Suppl. 1998 Dec;8(7):S1-11 [9879128.001]
  • [Cites] Commun Dis Public Health. 1999 Jun;2(2):96-100 [10402742.001]
  • [Cites] Diabetologia. 1999 Jul;42(7):793-801 [10440120.001]
  • [Cites] Eur J Epidemiol. 1999 May;15(5):467-73 [10442473.001]
  • [Cites] Br J Gen Pract. 2003 Oct;53(495):778-83 [14601353.001]
  • [Cites] Thorax. 2000 Aug;55(8):662-5 [10899242.001]
  • [Cites] Commun Dis Public Health. 2000 Sep;3(3):213-5 [11014039.001]
  • [Cites] Diabet Med. 2001 Feb;18(2):126-32 [11251676.001]
  • [Cites] N Engl J Med. 2001 May 3;344(18):1343-50 [11333990.001]
  • [Cites] Br J Gen Pract. 2001 Aug;51(469):638-43 [11510393.001]
  • [CommentIn] Br J Gen Pract. 2005 Nov;55(520):884 [16282011.001]
  • (PMID = 16105366.001).
  • [ISSN] 0960-1643
  • [Journal-full-title] The British journal of general practice : the journal of the Royal College of General Practitioners
  • [ISO-abbreviation] Br J Gen Pract
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1463227
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26. Suwattee P, McClelland MC, Huiras EE, Warshaw EM, Lee PK, Kaye VN, McCalmont TH, Niehans GA: Plaque-type syringoma: two cases misdiagnosed as microcystic adnexal carcinoma. J Cutan Pathol; 2008 Jun;35(6):570-4
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  • This benign neoplasm may be easily misdiagnosed as microcystic adnexal carcinoma (MAC), potentially resulting in unnecessary surgery with disfiguring consequences.
  • RESULTS AND CONCLUSIONS: Our cases are discussed in the context of histopathologic diagnosis.
  • Detailed histopathologic findings of syringoma, as well as other considerations in the differential diagnosis, are reviewed.
  • [MeSH-major] Carcinoma, Skin Appendage / diagnosis. Cysts / pathology. Diagnostic Errors. Skin Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis. Syringoma / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Treatment Outcome


27. Scholz T, Kretsis V, Kobayashi MR, Evans GR: Long-term outcomes after primary breast reconstruction using a vertical skin pattern for skin-sparing mastectomy. Plast Reconstr Surg; 2008 Dec;122(6):1603-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term outcomes after primary breast reconstruction using a vertical skin pattern for skin-sparing mastectomy.
  • BACKGROUND: Preservation of the breast skin envelope in skin-sparing mastectomy is the key component for superior aesthetic results.
  • Breast mound disproportions in primary breast reconstruction caused by a mismatch between retained skin envelope and donor-tissue volume provokes breast shape asymmetries.
  • A skin-sparing mastectomy using a vertical pattern can address these breast mound imperfections by adjusting this mismatch in a vertical direction.
  • METHODS: A retrospective chart review was conducted over a 10-year period for patients who underwent skin-sparing mastectomy using a vertical pattern for malignant, premalignant, benign, and deformational disease of the breast.
  • RESULTS: Seventy-two patients, aged 31 to 69 years (mean, 51.5 years), underwent 106 skin-sparing mastectomies using a vertical pattern and primary reconstruction with 38 unilateral and 34 bilateral free flaps (muscle-sparing transverse rectus abdominis musculocutaneous or deep inferior epigastric perforator flaps).
  • The complication rates of 8.49 percent at the donor site and 6.60 percent at the flap site show a direct correlation to smoking but no correlation to body mass index, cancer stage, or diabetes.
  • CONCLUSIONS: Skin-sparing mastectomy using a vertical pattern improves the aesthetic outcome in primary breast reconstruction without compromising oncologic safety and demonstrates low morbidity.
  • Elimination of the disharmony between skin flap and breast volume in the vertical direction while respecting the inframammary crease produces a youthful, symmetrical conical breast shape with medial fullness.
  • [MeSH-major] Breast Neoplasms / surgery. Dermatologic Surgical Procedures. Mammaplasty / methods. Mastectomy. Surgical Flaps
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Middle Aged. Neoplasm Recurrence, Local. Postoperative Complications. Retrospective Studies


28. Schlosser KA: Infantile hemangioma: how to treat this benign neoplasm of childhood. JAAPA; 2009 May;22(5):46-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Infantile hemangioma: how to treat this benign neoplasm of childhood.
  • [MeSH-major] Hemangioma / therapy. Skin Neoplasms / therapy

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  • (PMID = 19469391.001).
  • [ISSN] 1547-1896
  • [Journal-full-title] JAAPA : official journal of the American Academy of Physician Assistants
  • [ISO-abbreviation] JAAPA
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Aminoquinolines; 0 / Antineoplastic Agents; 0 / Interferon-alpha; 99011-02-6 / imiquimod
  • [Number-of-references] 11
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29. Mahalingam M, Alter JN, Bhawan J: Multiple cellular neurothekeomas--a case report and review on the role of immunohistochemistry as a histologic adjunct. J Cutan Pathol; 2006 Jan;33(1):51-6
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  • BACKGROUND: Cellular neurothekeoma is a relatively rare, benign cutaneous neoplasm, which usually presents as a solitary papule or nodule involving the head and neck area of young adults.
  • [MeSH-major] Immunohistochemistry / methods. Neoplasms, Multiple Primary / pathology. Neurothekeoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Biopsy. Humans. Male. Neoplasm Recurrence, Local

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  • (PMID = 16441413.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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30. Suchak R, Luzar B, Bacchi CE, Maguire B, Calonje E: Cutaneous neuroblastoma-like schwannoma: a report of two cases, one with a plexiform pattern, and a review of the literature. J Cutan Pathol; 2010 Sep;37(9):997-1001
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  • [Title] Cutaneous neuroblastoma-like schwannoma: a report of two cases, one with a plexiform pattern, and a review of the literature.
  • Cutaneous schwannomas in their classical form are readily identified histologically.
  • It is a benign sporadic neoplasm with no reported association with neurofibromatosis, and is characterized histologically by small round lesional cells surrounding collagenous cores forming rosette-like structures.
  • The differential diagnosis includes other lesions with the formation of rosettes including neuroblastoma, low-grade fibromyxoid sarcoma and dendritic cell neurofibroma, as well as primitive neuroectodermal tumors and rare malignant transformation in a schwannoma.
  • [MeSH-major] Neurilemmoma / pathology. Neuroblastoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Female. Humans. Treatment Outcome

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  • (PMID = 19922484.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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31. Joyner DE, Wade ML, Szabo A, Bastar J, Coffin CM, Albritton KH, Bernard PS, Randall RL: Discriminate gene lists derived from cDNA microarray profiles of limited samples permit distinguishing mesenchymal neoplasia ex vivo. J Cancer Res Clin Oncol; 2005 Mar;131(3):137-46
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  • [Title] Discriminate gene lists derived from cDNA microarray profiles of limited samples permit distinguishing mesenchymal neoplasia ex vivo.
  • BACKGROUND: Mesenchymal neoplasia comprises a heterogeneous group of tumors with over 200 benign neoplasms and 100 sarcomas.
  • Currently, tumors are classified using histologic and immunocytologic characteristics, with diagnostic error rates reported as high as 40% of cases.
  • As a feasibility study, our goal was to generate a preliminary discriminatory gene list for selected mesenchymal tumors, including sarcomas.
  • This technique may enable an eventual molecular classification schema based on expression profiles that can complement current clinical and pathologic diagnostic procedures in mesenchymal tumors.
  • METHODS: cDNA microarray analyses were preformed on connective tissue tumors obtained at time of surgical resection or biopsy.
  • Messenger RNA (mRNA) from four general tumor classes was competitively hybridized against a human dermal fibroblast cell line comparator and the resulting gene expression profiles processed by ANOVA and linear discriminate analysis.
  • RESULTS: The tissue classification involved 18 patients with malignant peripheral nerve sheath tumors, giant cell containing tumors, benign spindle cell lesions, or Ewing's family of tumors.
  • CONCLUSIONS: Linear discriminate analysis of cDNA gene expression profiles partitioned mesenchymal tumor classes, even when constrained by limited sample sizes.
  • [MeSH-major] DNA Fingerprinting. DNA, Neoplasm / analysis. Mesenchymoma / diagnosis. Mesenchymoma / genetics. Neoplasms, Connective Tissue / diagnosis. Neoplasms, Connective Tissue / genetics. Oligonucleotide Array Sequence Analysis
  • [MeSH-minor] Analysis of Variance. Carcinoma / diagnosis. Carcinoma / genetics. Carcinoma, Giant Cell / diagnosis. Carcinoma, Giant Cell / genetics. Cell Line. Feasibility Studies. Fibroblasts. Gene Expression Regulation, Neoplastic. Humans. Linear Models. Nerve Sheath Neoplasms / diagnosis. Nerve Sheath Neoplasms / genetics. RNA, Messenger / analysis. RNA, Neoplasm / analysis. Sarcoma, Ewing / diagnosis. Sarcoma, Ewing / genetics. Skin / cytology

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  • [Cites] Cancer Res. 2002 Mar 1;62(5):1256-60 [11888886.001]
  • [Cites] Science. 1996 Aug 30;273(5279):1236-8 [8703060.001]
  • [Cites] Am J Clin Pathol. 2001 Oct;116(4):473-6 [11601130.001]
  • [Cites] Cell. 2000 Oct 13;103(2):211-25 [11057895.001]
  • [Cites] J Biol Chem. 1990 Feb 15;265(5):2665-70 [2406238.001]
  • [Cites] J Clin Oncol. 2002 Mar 1;20(5):1329-34 [11870176.001]
  • [Cites] Clin Orthop Relat Res. 2003 Oct;(415 Suppl):S110-9 [14600600.001]
  • [Cites] Lancet. 2002 Apr 13;359(9314):1301-7 [11965276.001]
  • [Cites] Math Biosci. 2002 Mar;176(1):71-98 [11867085.001]
  • [Cites] Cancer Res. 2001 Sep 15;61(18):6649-55 [11559528.001]
  • [Cites] J Comput Biol. 2000;7(6):819-37 [11382364.001]
  • [Cites] Clin Cancer Res. 2000 Dec;6(12):4776-81 [11156234.001]
  • [Cites] J Cell Physiol. 2003 May;195(2):309-21 [12652657.001]
  • [Cites] Cancer Control. 2001 May-Jun;8(3):239-51 [11378650.001]
  • [Cites] J Clin Oncol. 1999 Dec;17(12):3695-6 [10577840.001]
  • [Cites] Annu Rev Cell Dev Biol. 2003;19:207-35 [14570569.001]
  • [Cites] Hum Mutat. 2000;16(1):18-22 [10874300.001]
  • [Cites] J Cell Biochem. 2000 Jun 12;78(4):627-37 [10861860.001]
  • [Cites] Cancer Cell. 2002 Sep;2(3):175-8 [12242149.001]
  • [Cites] FASEB J. 1999 May;13(8):781-92 [10224222.001]
  • [Cites] Nat Med. 2001 Jun;7(6):673-9 [11385503.001]
  • [Cites] Bioinformatics. 2003 Jan;19(1):53-61 [12499293.001]
  • [Cites] Cancer Res. 2002 Oct 15;62(20):5859-66 [12384549.001]
  • [Cites] Cancer Res. 2002 Apr 15;62(8):2281-6 [11956084.001]
  • [Cites] Curr Opin Cell Biol. 1995 Oct;7(5):728-35 [8573349.001]
  • [Cites] Nature. 2000 Feb 3;403(6769):503-11 [10676951.001]
  • [Cites] Annu Rev Cell Dev Biol. 2001;17:463-516 [11687497.001]
  • [Cites] Clin Orthop Relat Res. 2003 Oct;(415):59-63 [14612630.001]
  • [Cites] J Cell Physiol. 1999 May;179(2):170-8 [10199556.001]
  • [Cites] Oncogene. 1999 Mar 4;18(9):1771-6 [10208438.001]
  • [Cites] Oncogene. 1995 Apr 6;10(7):1461-3 [7731700.001]
  • [Cites] Cancer Res. 2003 Jul 1;63(13):3539-45 [12839939.001]
  • [Cites] J Cell Biol. 2000 Feb 21;148(4):779-90 [10684258.001]
  • [Cites] Cancer Res. 2001 Mar 1;61(5):1791-5 [11280724.001]
  • [Cites] Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5116-21 [11309499.001]
  • [Cites] Am J Pathol. 1998 Jul;153(1):91-101 [9665469.001]
  • [Cites] Cancer Res. 1999 Nov 15;59(22):5656-61 [10582678.001]
  • [Cites] Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13085-9 [12351679.001]
  • [Cites] J Clin Oncol. 1983 Aug;1(8):496-509 [6366142.001]
  • (PMID = 15614524.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / RNA, Messenger; 0 / RNA, Neoplasm
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32. Abeysekara AM, Siriwardana HP, Abbas KF, Tanner P, Ojo AA: An unusually large myofibroblastoma in a male breast: a case report. J Med Case Rep; 2008;2:157
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  • INTRODUCTION: Myofibroblastoma of the breast is a rare benign stromal tumour seen predominantly in men.
  • We present a case of an unusually large myofibroblastoma, which mimicked a malignant breast tumour.
  • Examination revealed a firm 15 cm hemispherical lump occupying the whole of the right breast with peau d'orange appearance of the overlying skin and distortion of the nipple.
  • However, a guided Tru-Cut biopsy was inconclusive.
  • A mastectomy was performed to remove the tumour, which weighed more than 2 kg.
  • Myofibroblastomas can mimic malignant neoplasms and the clinical significance of this entity lies primarily in its recognition as a distinctive benign neoplasm.

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  • [Cites] Am J Surg Pathol. 2001 Aug;25(8):1022-9 [11474286.001]
  • [Cites] Am J Surg Pathol. 1994 Nov;18(11):1170-6 [7943539.001]
  • [Cites] Am J Surg Pathol. 1979 Dec;3(6):535-42 [534390.001]
  • [Cites] Am J Surg Pathol. 1987 Jul;11(7):493-502 [3037930.001]
  • (PMID = 18479528.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2396649
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33. Moretti D, Del Bello B, Cosci E, Biagioli M, Miracco C, Maellaro E: Novel variants of muscle calpain 3 identified in human melanoma cells: cisplatin-induced changes in vitro and differential expression in melanocytic lesions. Carcinogenesis; 2009 Jun;30(6):960-7
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  • Interestingly, among melanocytic lesions, the expression of these novel variants is significantly downregulated, compared with benign nevi, in the most aggressive ones, i.e. in vertical growth phase melanoma and, even more, in metastatic melanoma cells, characterized by invasiveness properties and usually highly resistant to apoptosis.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Calpain / metabolism. Cisplatin / pharmacology. Melanoma / metabolism. Muscle Proteins / metabolism. Nevus / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Alternative Splicing. Apoptosis. Biopsy. Cell Line, Tumor. Cell Nucleolus / metabolism. Cytoplasm / metabolism. Dipeptides / pharmacology. Dysplastic Nevus Syndrome / metabolism. Gene Expression Regulation, Neoplastic. Humans. Neoplasm Metastasis. RNA, Messenger / metabolism


34. Siddha M, Budrukkar A, Shet T, Deshpande M, Basu A, Patil N, Bhalavat R: Malignant pilar tumor of the scalp: a case report and review of literature. J Cancer Res Ther; 2007 Oct-Dec;3(4):240-3
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  • [Title] Malignant pilar tumor of the scalp: a case report and review of literature.
  • Pilar tumor is a rare neoplasm arising from the external root sheath of the hair follicle and is most commonly observed on the scalp.
  • These tumors are largely benign, often cystic, and are characterized by trichilemmal keratinization.
  • In this report, we present a case of malignant pilar tumor of the scalp with multiple nodal metastases at presentation.
  • [MeSH-major] Hair Diseases / pathology. Pilomatrixoma / secondary. Scalp. Skin Neoplasms / pathology

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  • (PMID = 18270401.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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35. Rajasekhar G, Mushtaq M, Vura NG, Shekar R, Kumar S: Condyloma acuminatum associated with odontogenic myxoma: a case report. J Maxillofac Oral Surg; 2009 Dec;8(4):384-7
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  • Condylomata acuminatum is a sexually transmitted infectious disease caused by human papiloma virus on the skin.
  • Odontogenic myxoma is a rare tumor of jaws which occurs in the tooth-bearing areas of the mandible and maxilla.
  • It is an uncommon, benign, but locally aggressive neoplasm.

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  • [Cites] Br J Vener Dis. 1978 Dec;54(6):433-40 [581655.001]
  • [Cites] Oral Surg Oral Med Oral Pathol. 1968 Oct;26(4):434-40 [5244772.001]
  • [Cites] Dermatol Surg. 2003 Mar;29(3):300-3 [12614429.001]
  • [Cites] Int J Oral Maxillofac Surg. 2008 Dec;37(12):1159-61 [18774261.001]
  • [Cites] Br J Vener Dis. 1983 Oct;59(5):325-6 [6311323.001]
  • [Cites] Jpn J Clin Oncol. 1996 Dec;26(6):393-7 [9001342.001]
  • [Cites] Sao Paulo Med J. 1997 Mar-Apr;115(2):1383-9 [9460298.001]
  • [Cites] J Clin Pathol. 1965 Mar;18:142-9 [14276146.001]
  • [Cites] Histopathology. 2004 Mar;44(3):216-21 [14987224.001]
  • [Cites] J Contemp Dent Pract. 2006 Feb 15;7(1):117-24 [16491154.001]
  • [Cites] J Am Dent Assoc. 2003 Mar;134(3):331-4 [12699047.001]
  • (PMID = 23139551.001).
  • [ISSN] 0972-8279
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3454105
  • [Keywords] NOTNLM ; Autoinoculation / Condyloma acuminatum / HPV-6 / Odontogenic myxoma / Palate / Young adult
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36. Ikeda F, Dikic I: CYLD in ubiquitin signaling and tumor pathogenesis. Cell; 2006 May 19;125(4):643-5
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  • [Title] CYLD in ubiquitin signaling and tumor pathogenesis.
  • Absence of CYLD, which encodes a deubiquitinating enzyme, causes an inherited disease characterized by benign skin tumors.
  • [MeSH-major] Neoplasms / metabolism. Signal Transduction / physiology. Tumor Suppressor Proteins / metabolism. Ubiquitin / metabolism
  • [MeSH-minor] Genes, Tumor Suppressor. Humans. NF-kappa B / metabolism. Proto-Oncogene Proteins / metabolism. Transcription Factors

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  • [CommentOn] Cell. 2006 May 19;125(4):665-77 [16713561.001]
  • (PMID = 16713556.001).
  • [ISSN] 0092-8674
  • [Journal-full-title] Cell
  • [ISO-abbreviation] Cell
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / NF-kappa B; 0 / Proto-Oncogene Proteins; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 0 / Ubiquitin; 0 / proto-oncogene protein bcl-3
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37. Schmaltz R, Müller CS, Vogt T: [Sudden growth of previously indolent scalp nodule]. Hautarzt; 2010 Jun;61(6):518-21
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  • Cylindromas are benign adnexal tumors with eccrine and apocrine differentiation.
  • We present a case of scalp cylindromatosis in which a primary cutaneous adenoid-cystic carcinoma developed.
  • As our case shows, histological evaluation is mandatory, even when the clinical diagnosis seems obvious.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Cell Transformation, Neoplastic / pathology. Neoplasm Recurrence, Local / diagnosis. Neoplasms, Multiple Primary / diagnosis. Scalp. Skin Neoplasms / diagnosis

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  • [Cites] Br J Dermatol. 2001 Oct;145(4):653-6 [11703297.001]
  • [Cites] Dermatol Surg. 2003 Jun;29(6):647-9 [12786711.001]
  • [Cites] J Am Acad Dermatol. 2008 Apr;58(4):636-41 [18342709.001]
  • [Cites] Cancer. 1993 Sep 1;72(5):1618-23 [7688655.001]
  • (PMID = 20490442.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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38. Wong RP, Khosravi S, Martinka M, Li G: Myeloid leukemia-1 expression in benign and malignant melanocytic lesions. Oncol Rep; 2008 Apr;19(4):933-7
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  • [Title] Myeloid leukemia-1 expression in benign and malignant melanocytic lesions.
  • Myeloid leukemia-1 (Mcl-1) is an anti-apoptotic protein implicated in tumor progression.
  • Its expression was found to be elevated in many types of human cancers and is correlated with tumor progression.
  • [MeSH-major] Dysplastic Nevus Syndrome / metabolism. Melanoma / chemistry. Neoplasm Proteins / analysis. Nevus / chemistry. Proto-Oncogene Proteins c-bcl-2 / analysis

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  • (PMID = 18357378.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Myeloid Cell Leukemia Sequence 1 Protein; 0 / Neoplasm Proteins; 0 / Proto-Oncogene Proteins c-bcl-2
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39. Räsänen K, Vaheri A: TGF-beta1 causes epithelial-mesenchymal transition in HaCaT derivatives, but induces expression of COX-2 and migration only in benign, not in malignant keratinocytes. J Dermatol Sci; 2010 May;58(2):97-104
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  • [Title] TGF-beta1 causes epithelial-mesenchymal transition in HaCaT derivatives, but induces expression of COX-2 and migration only in benign, not in malignant keratinocytes.
  • BACKGROUND: Transforming growth factor beta (TGF-beta) acts as a tumor promoter by inducing epithelial-mesenchymal transition (EMT), which leads to a motile phenotype, enabling invasion and metastasis of cancer cells.
  • Cancer-related inflammation, mediated by prostaglandins, has been proposed as a critical mechanism in conversion of benign cells to malignant.
  • OBJECTIVE: Induction of cyclooxygenase 2 (COX-2), producer of prostaglandins, is thought to be a prerequisite for TGF-beta-induced EMT in benign cells.
  • We used HaCaT derivatives, representative of skin cancer progression, to investigate TGF-beta1 mediated EMT response, and the role of COX-2 in it.
  • RESULTS: TGF-beta1 caused proliferation arrest of benign and malignant HaCaT cells, and changed the epithelial morphology of benign and low-grade malignant cells, but not metastatic cells, to mesenchymal spindle-shape.
  • COX-2 and migration were induced only in benign HaCaT derivatives.
  • Malignant derivatives did not induce COX-2 in response to TGF-beta 1 treatment, thus emphasizing the role of inflammation in EMT response of benign cells.
  • CONCLUSIONS: TGF-beta1 operates via distinct mechanisms in inducing EMT and metastasis, and supporting this we show that TGF-beta1 induces COX-2 and promotes the migration of benign cells, but does not further augment the migration of malignant cells, indicating their resistance to TGF-beta1 in the context of motility.
  • [MeSH-minor] Cell Line, Tumor. Cell Movement. Cell Proliferation. Chemotaxis. Humans. Immunohistochemistry / methods. Models, Biological. Neoplasm Metastasis. Transforming Growth Factor beta / metabolism. Wound Healing

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  • [Copyright] 2010 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20399617.001).
  • [ISSN] 1873-569X
  • [Journal-full-title] Journal of dermatological science
  • [ISO-abbreviation] J. Dermatol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Transforming Growth Factor beta; 0 / Transforming Growth Factor beta1
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40. Abdulla AN, Covert AA, Grantmyre JE: Scrotal syringocystadenoma papilliferum: case report. Can J Urol; 2009 Jun;16(3):4684-6
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  • Syringocystadenoma papilliferum (SCAP) is a benign rare adnexal skin neoplasm, which in a third of cases arises from a nevus sebaceous and is most commonly found on the head and neck and in very rare instances found on the genitalia.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Scrotum / pathology. Skin Neoplasms / pathology. Syringoma / pathology

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  • (PMID = 19497181.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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41. Chechlinska M, Kowalewska M, Brzoska-Wojtowicz E, Radziszewski J, Ptaszynski K, Rys J, Kaminska J, Nowak R: Squamous cell carcinoma antigen 1 and 2 expression in cultured normal peripheral blood mononuclear cells and in vulvar squamous cell carcinoma. Tumour Biol; 2010 Dec;31(6):559-67
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  • Serum levels of SCCA are elevated in patients with benign skin diseases and in patients with SCC.
  • In VSCC, in addition to tumour itself, metastatic lymph nodes seem also to be a potential source of serum SCCA.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Carcinoma, Squamous Cell / metabolism. Leukocytes, Mononuclear / metabolism. Serpins / metabolism. Vulvar Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cell Line, Tumor. Cells, Cultured. Female. Humans. RNA, Messenger / metabolism

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  • [Cites] Eur J Cancer. 2006 Nov;42(16):2671-4 [16978860.001]
  • [Cites] Tumour Biol. 2006;27(3):142-52 [16641548.001]
  • [Cites] FEBS Lett. 2007 Sep 4;581(22):4260-4 [17707374.001]
  • [Cites] Crit Rev Oncol Hematol. 2008 Apr;66(1):10-20 [17964182.001]
  • [Cites] Nat Rev Cancer. 2010 Jan;10(1):2-3 [20050335.001]
  • [Cites] J Gene Med. 2010 Jun;12(6):545-54 [20527047.001]
  • [Cites] J Histochem Cytochem. 2000 Jan;48(1):113-22 [10653592.001]
  • [Cites] Int J Cancer. 2000 Jul 20;89(4):368-77 [10956412.001]
  • [Cites] Oncol Rep. 2001 Mar-Apr;8(2):347-54 [11182054.001]
  • [Cites] Int J Cancer. 2001 Jan 20;95(1):39-43 [11241309.001]
  • [Cites] Cancer Lett. 2001 Jun 26;167(2):205-13 [11369142.001]
  • [Cites] Eur J Cancer. 2002 Oct;38(15):1987-91 [12376202.001]
  • [Cites] J Reprod Med. 2002 Sep;47(9):718-20 [12380452.001]
  • [Cites] Cytokine. 2002 Sep 21;19(6):287-96 [12421571.001]
  • [Cites] Neoplasma. 2004;51(2):103-9 [15190419.001]
  • [Cites] Cancer. 1977 Oct;40(4):1621-8 [332328.001]
  • [Cites] J Cell Biol. 1988 Mar;106(3):761-71 [2450098.001]
  • [Cites] Cancer. 1989 Oct 15;64(8):1652-6 [2790678.001]
  • [Cites] Gynecol Oncol. 1989 Nov;35(2):227-32 [2807015.001]
  • [Cites] Clin Chem. 1990 Feb;36(2):251-4 [2302769.001]
  • [Cites] Biochem Biophys Res Commun. 1991 Nov 27;181(1):51-8 [1958219.001]
  • [Cites] Cancer. 1990 Oct 1;66(7):1505-12 [2208001.001]
  • [Cites] J Am Acad Dermatol. 1990 Apr;22(4):639-42 [2319025.001]
  • [Cites] Chest. 1994 Mar;105(3):773-6 [8131539.001]
  • [Cites] J Dermatol. 1994 Feb;21(2):67-72 [8182213.001]
  • [Cites] Cancer. 1995 Sep 1;76(5):758-64 [8625177.001]
  • [Cites] Tumour Biol. 1996;17(2):81-9 [8658017.001]
  • [Cites] J Biol Chem. 1997 Jan 17;272(3):1849-55 [8999871.001]
  • [Cites] Int J Cancer. 1997 Feb 20;74(1):75-80 [9036873.001]
  • [Cites] Biochemistry. 1998 Apr 14;37(15):5258-66 [9548757.001]
  • [Cites] Tumour Biol. 1998;19(6):517-26 [9817981.001]
  • [Cites] Int J Cancer. 1999 Oct 8;83(2):167-70 [10471522.001]
  • [Cites] J Biol Chem. 2005 Mar 18;280(11):9761-4 [15677460.001]
  • [Cites] Gynecol Oncol. 2005 Jun;97(3):904-7 [15894354.001]
  • [Cites] Clin Exp Allergy. 2005 Oct;35(10):1327-33 [16238792.001]
  • [Cites] Int J Gynecol Cancer. 2007 Jan-Feb;17(1):174-81 [17291250.001]
  • (PMID = 20589490.001).
  • [ISSN] 1423-0380
  • [Journal-full-title] Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • [ISO-abbreviation] Tumour Biol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / RNA, Messenger; 0 / Serpins; 0 / squamous cell carcinoma-related antigen
  • [Other-IDs] NLM/ PMC2953620
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42. Berman DM, Wincovitch S, Garfield S, Romeo MJ: Grading melanocytic dysplasia in paraffin wax embedded tissue by the nucleic acid index. J Clin Pathol; 2005 Nov;58(11):1206-10
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  • BACKGROUND: Although nucleic acid derangements are the hallmark of melanocytic dysplasia, the gold standard for its diagnosis remains the microscopic evaluation of haematoxylin and eosin stained slides.
  • RESULTS: When applied to benign naevi, dysplastic naevi, and melanoma, a very strong significant association was seen between lower NAI and malignant potential (p < 0.0001).
  • Interestingly, the NAI for dysplastic naevi is between that of melanoma and most benign naevi, consistent with their intermediate biological behaviour and histological appearance.
  • CONCLUSION: By providing a quantitative measure for melanocytic neoplasia, the NAI may improve the diagnosis of melanocytic lesions and the selection of treatment.
  • [MeSH-major] DNA, Neoplasm / analysis. Dysplastic Nevus Syndrome / diagnosis. Melanoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Image Processing, Computer-Assisted / methods. Melanocytes / pathology. Microscopy, Confocal / methods. Mitotic Index. Nevus, Pigmented / diagnosis. Nevus, Pigmented / genetics. Nevus, Pigmented / pathology. Paraffin Embedding. RNA, Neoplasm / analysis

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  • [Cites] Acta Neuropathol. 1998 Nov;96(5):487-94 [9829812.001]
  • [Cites] Clin Cancer Res. 1996 Feb;2(2):419-26 [9816186.001]
  • [Cites] Nat Genet. 2003 Jan;33(1):19-20 [12447372.001]
  • [Cites] Am J Dermatopathol. 2003 Jun;25(3):190-7 [12775980.001]
  • [Cites] Oncogene. 2003 May 19;22(20):3081-6 [12789284.001]
  • [Cites] Mod Pathol. 2003 Aug;16(8):764-71 [12920220.001]
  • [Cites] Anal Quant Cytol Histol. 2003 Oct;25(5):243-53 [14603721.001]
  • [Cites] Melanoma Res. 2003 Dec;13(6):581-6 [14646621.001]
  • [Cites] Br J Dermatol. 2004 Feb;150(2):179-85 [14996086.001]
  • [Cites] J Invest Dermatol. 2004 Feb;122(2):342-8 [15009715.001]
  • [Cites] J Am Acad Dermatol. 2004 Jul;51(1 Suppl):S65-9 [15243517.001]
  • [Cites] Am J Clin Pathol. 2004 Jun;121 Suppl:S3-32 [15298148.001]
  • [Cites] Lancet. 1977 Apr 16;1(8016):864-5 [67377.001]
  • [Cites] Arch Dermatol. 1978 May;114(5):732-8 [646394.001]
  • [Cites] Cancer Res. 1978 Jul;38(7):1893-8 [77721.001]
  • [Cites] Microsc Acta. 1981 Jan;84(1):37-42 [6163065.001]
  • [Cites] Cytometry. 1982 Jan;2(4):212-8 [6173180.001]
  • [Cites] Cytometry. 1982 Jul;3(1):28-35 [6180873.001]
  • [Cites] Am J Clin Pathol. 1985 Jun;83(6):722-5 [2408462.001]
  • [Cites] J Am Acad Dermatol. 1989 Oct;21(4 Pt 1):773-80 [2808793.001]
  • [Cites] J Cutan Pathol. 1993 Apr;20(2):121-5 [8320355.001]
  • [Cites] Kurume Med J. 1994;41(1):1-13 [7933912.001]
  • [Cites] Hum Pathol. 1996 Jun;27(6):528-31 [8666360.001]
  • [Cites] Cytometry. 1997 Feb 1;27(2):99-105 [9012376.001]
  • [Cites] Histochem Cell Biol. 1997 Apr;107(4):267-78 [9151109.001]
  • [Cites] Cancer. 2000 Mar 15;88(6):1370-7 [10717619.001]
  • (PMID = 16254113.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / RNA, Neoplasm
  • [Other-IDs] NLM/ PMC1770753
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43. Mentzel T, Dei Tos AP, Sapi Z, Kutzner H: Myopericytoma of skin and soft tissues: clinicopathologic and immunohistochemical study of 54 cases. Am J Surg Pathol; 2006 Jan;30(1):104-13
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  • [Title] Myopericytoma of skin and soft tissues: clinicopathologic and immunohistochemical study of 54 cases.
  • Perivascular neoplasms comprise traditionally glomus tumor and hemangiopericytoma (HPC).
  • Whereas glomus tumor represents a well-defined entity, the existence of HPC as a separate entity has been questioned because a number of neoplasms of different lines of differentiation are characterized by a HPC-like vascular growth pattern.
  • A large series of myopericytoma of skin and soft tissues has been analyzed to further characterize the clinicopathologic spectrum of this entity.
  • Fifty-four cases of myopericytoma of skin and soft tissues were retrieved and the histology reviewed.
  • In 20 cases, the neoplasms were confined to the dermis, in 6 cases an extension into the subcutis was seen, and 24 as well as 4 cases arose in subcutaneous and deep soft tissue, respectively.
  • Histologically, in all cases, numerous thin-walled vessels and a concentric, perivascular arrangement of ovoid, plump spindled to round myoid tumor cells was seen.
  • However, a broad morphologic spectrum ranging from hypocellular, fibroma-like (3 cases), myofibroma-like (2 cases), angioleiomyoma-like (12 cases), and HPC-like neoplasms (13 cases) to classic myopericytomas (14 cases) and immature, cellular lesions (2 cases) was noted.
  • In addition, 2 neoplasms with focal glomoid features, 5 intravascular, and 1 malignant myopericytomas were found.
  • Despite marginal or incomplete excision in 23 of 46 cases, only 2 neoplasms (1 malignant and 1 intravascular myopericytoma) recurred locally (within 1 and 4 years, respectively).
  • Despite overlapping morphologic features to angioleiomyoma and myofibroma, myopericytoma represents a distinct perivascular, myoid neoplasm of skin and soft tissues, characterized by a broad morphologic spectrum of concentrically, perivascularly growing myoid tumor cells that stain positively for ASMA and often for h-caldesmon, whereas desmin is usually negative.
  • Most cases of myopericytoma behave in a benign fashion, but local recurrences and rarely metastases may occur in atypical and malignant neoplasms.
  • [MeSH-major] Biomarkers, Tumor / analysis. Neoplasms, Vascular Tissue / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Angiomyoma / pathology. Diagnosis, Differential. Female. Glomus Tumor / pathology. Hemangiopericytoma / metabolism. Hemangiopericytoma / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Myofibroma / pathology

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  • (PMID = 16330949.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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44. Gomez-Moyano E, Vera-Casaño A, Martinez-Garcia S, Sanz-Trelles A, Crespo-Erchiga V: Two cases of dermatomyofibroma (plaque-like dermal fibromatosis). Int J Dermatol; 2010 Aug;49(8):914-7
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  • BACKGROUND: Dermatomyofibroma is a rare but distinct benign cutaneous mesenchymal neoplasm of fibroblastic/myofibroblastic differentiation.
  • In both cases, histological examination showed a spindle-cell proliferation embedded among the collagen fibers of the dermis, arranged predominantly parallel to the skin surface.
  • CONCLUSION: Dermatologists and pediatricians should be aware of this benign entity in order to avoid unnecessary treatment.
  • [MeSH-major] Dermis / pathology. Fibroblasts / pathology. Histiocytoma, Benign Fibrous / diagnosis. Muscle, Smooth / pathology. Skin Neoplasms / diagnosis

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  • [Copyright] © 2010 The International Society of Dermatology.
  • (PMID = 21174375.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. De Felice B, Garbi C, Santoriello M, Santillo A, Wilson RR: Differential apoptosis markers in human keloids and hypertrophic scars fibroblasts. Mol Cell Biochem; 2009 Jul;327(1-2):191-201
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  • Keloids are benign skin tumors and are the effect of a dysregulated wound-healing process in genetically predisposed patients.
  • [MeSH-minor] Adult. Biomarkers / metabolism. Cells, Cultured. Female. Humans. Male. Reactive Oxygen Species / metabolism. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 / metabolism. Wound Healing

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  • [Cites] DNA Cell Biol. 2007 Aug;26(8):541-7 [17688405.001]
  • [Cites] Ann Plast Surg. 2005 Jul;55(1):69-75; discussion 75 [15985794.001]
  • [Cites] J Am Acad Dermatol. 1995 Jul;33(1):117-23 [7601928.001]
  • [Cites] Proc Natl Acad Sci U S A. 1980 Aug;77(8):4420-4 [6254023.001]
  • [Cites] Wound Repair Regen. 1998 Jan-Feb;6(1):28-37 [9776848.001]
  • [Cites] Arch Dermatol. 1998 Aug;134(8):963-7 [9722726.001]
  • [Cites] Science. 1994 Jul 15;265(5170):346-55 [8023157.001]
  • [Cites] Trends Pharmacol Sci. 2004 Apr;25(4):177-81 [15116721.001]
  • [Cites] Nat Rev Mol Cell Biol. 2000 Dec;1(3):199-207 [11252895.001]
  • [Cites] Zhonghua Zheng Xing Wai Ke Za Zhi. 2003 Mar;19(2):95-7 [12889183.001]
  • [Cites] Cancer Res. 2000 Jul 1;60(13):3370-4 [10910040.001]
  • [Cites] Neurosci Lett. 2003 Dec 4;352(2):105-8 [14625034.001]
  • [Cites] J Cell Sci. 2006 Dec 15;119(Pt 24):5015-20 [17158908.001]
  • [Cites] Blood. 1997 Jun 1;89(11):4175-81 [9166861.001]
  • [Cites] Am J Pathol. 1994 Jul;145(1):105-13 [8030742.001]
  • [Cites] Int J Oncol. 1999 Dec;15(6):1149-53 [10568821.001]
  • [Cites] Blood. 1997 Mar 1;89(5):1748-53 [9057659.001]
  • [Cites] J Dermatol Sci. 2004 Feb;34(1):17-24 [14757278.001]
  • [Cites] Hum Genet. 1993 Mar;91(1):25-30 [8454284.001]
  • [Cites] Wound Repair Regen. 2007 Sep-Oct;15 Suppl 1:S6-17 [17727469.001]
  • [Cites] Differentiation. 1991 Apr;46(3):181-6 [1655543.001]
  • [Cites] Science. 1991 Jul 5;253(5015):49-53 [1905840.001]
  • [Cites] Nat Rev Cancer. 2002 Aug;2(8):594-604 [12154352.001]
  • [Cites] J Cell Biochem. 2007 Mar 1;100(4):883-96 [17031865.001]
  • [Cites] Am J Pathol. 1995 Sep;147(3):790-8 [7677190.001]
  • [Cites] J Cell Physiol. 2004 Mar;198(3):350-8 [14755540.001]
  • [Cites] Chem Res Toxicol. 1997 Apr;10(4):393-400 [9114975.001]
  • [Cites] Zhonghua Shao Shang Za Zhi. 2004 Apr;20(2):85-7 [15312469.001]
  • [Cites] Curr Opin Pediatr. 2006 Aug;18(4):396-402 [16914994.001]
  • [Cites] J Surg Res. 1993 Aug;55(2):214-22 [8412102.001]
  • [Cites] Mol Genet Genomics. 2004 Aug;272(1):28-34 [15248062.001]
  • [Cites] Trends Mol Med. 2006 Sep;12(9):440-50 [16899408.001]
  • [Cites] Apoptosis. 2000 Nov;5(5):415-8 [11256882.001]
  • [Cites] Dermatol Surg. 2008 Mar;34(3):336-46 [18177398.001]
  • [Cites] Oncogene. 1998 Nov 26;17(21):2753-60 [9840939.001]
  • [Cites] Neuron. 1995 Feb;14(2):303-15 [7857640.001]
  • [Cites] Plast Reconstr Surg. 2007 May;119(6):1714-21 [17440345.001]
  • [Cites] Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7262-6 [1353891.001]
  • [Cites] Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8405-9 [1924299.001]
  • [Cites] Ann Plast Surg. 2005 Jun;54(6):676-80 [15900161.001]
  • [Cites] Plast Reconstr Surg. 2001 Mar;107(3):797-808 [11304607.001]
  • [Cites] Int J Cancer. 2000 Jun 1;86(5):684-9 [10797291.001]
  • [Cites] Proc Natl Acad Sci U S A. 1989 Jan;86(1):232-6 [2643100.001]
  • [Cites] Oncogene. 1999 Nov 1;18(45):6145-57 [10557106.001]
  • [Cites] J Pathol. 1999 Jan;187(1):112-26 [10341712.001]
  • [Cites] Wound Repair Regen. 1999 Nov-Dec;7(6):511-7 [10633011.001]
  • [Cites] Nature. 2000 Nov 16;408(6810):307-10 [11099028.001]
  • [Cites] Cell Mol Life Sci. 1999 Jan;55(1):28-37 [10065149.001]
  • [Cites] Zhonghua Zheng Xing Wai Ke Za Zhi. 2003 Jul;19(4):258-60 [14628411.001]
  • (PMID = 19224335.001).
  • [ISSN] 1573-4919
  • [Journal-full-title] Molecular and cellular biochemistry
  • [ISO-abbreviation] Mol. Cell. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Reactive Oxygen Species; 0 / Tumor Suppressor Protein p53
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46. Estrada-Chavez G, Vega-Memije ME, Lacy-Niebla RM, Toussaint-Caire S: Scalp metastases of a renal cell carcinoma. Skinmed; 2006 May-Jun;5(3):148-50
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  • An 80-year-old man presented with a localized tumor of the right occipital scalp.
  • The tumor was a 1-cm, bright red-purple, ulcerated, and crusted exophytic nodule on a smooth base (Figure 1).
  • It was extirpated with the clinical diagnosis of pyogenic granuloma vs. renal metastasis to the scalp.
  • The patient's medical history included a transurethral prostatic resection 3 years earlier and, 1 year later, a right nephrectomy for a 2-kg kidney tumor verbally reported as "benign."
  • The histopathologic diagnosis of metastatic renal cell carcinoma was supported by immunohistochemistry with positive epithelial membrane antigen staining (Figure 4).
  • [MeSH-major] Carcinoma, Renal Cell / diagnosis. Head and Neck Neoplasms / diagnosis. Kidney Neoplasms / diagnosis. Scalp / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Humans. Male. Neoplasm Metastasis


47. Carlson JA, Ross JS, Slominski AJ: New techniques in dermatopathology that help to diagnose and prognosticate melanoma. Clin Dermatol; 2009 Jan-Feb;27(1):75-102
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  • Routine light microscopy supplemented with immunohistochemistry in cases of metastatic or spindle cell melanoma are standards of care for the diagnosis and staging of melanoma.
  • Not all melanocytic tumors can be confidently classified as melanoma or benign nevus by histology, however.
  • In addition, tumor thickness and ulceration, the current American Joint Classification on Cancer prognosticators for primary cutaneous (stages I and II) melanoma used in clinical practice, do not perfectly predict an individual's clinical course.
  • Recent advances in molecular techniques and bioinformatics mandate testing and use of novel methods for the detection, diagnosis, and classification of melanocytic tumors that can accurately predict tumor behavior and help in selecting the most optimal and individualized therapy.
  • [MeSH-major] Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Cytogenetic Analysis. Dermatology / methods. Humans. Immunohistochemistry. Molecular Diagnostic Techniques. Neoplasm Staging. Prognosis

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  • (PMID = 19095155.001).
  • [ISSN] 1879-1131
  • [Journal-full-title] Clinics in dermatology
  • [ISO-abbreviation] Clin. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 288
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48. Kosmidis C, Efthimiadis C, Anthimidis G, Karayannopoulou G, Grigoriou M, Vassiliadou K, Berovali E, Fachantidis P, Fahantidis E: Kaposi's sarcoma of the hand mimicking squamous cell carcinoma in a woman with no evidence of HIV infection: a case report. J Med Case Rep; 2008;2:213
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  • INTRODUCTION: Kaposi's sarcoma is a vascular neoplasm mainly affecting the skin of the lower extremities.
  • Although it is the most common neoplasm affecting patients with AIDS, sporadic cases in HIV-negative people have been reported.
  • It is a lesion mainly affecting men and its clinical presentation presents a challenge, as it can resemble other benign or malignant skin lesions.
  • The patient was treated with a wide excision of the lesion and primary reconstruction with a full thickness skin graft.
  • CONCLUSION: Kaposi's sarcoma, although rare in its sporadic form, should be considered in the differential diagnosis of indeterminate skin lesions, especially those affecting the extremities.

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  • [Cites] Semin Cancer Biol. 1999 Jun;9(3):151-64 [10343067.001]
  • [Cites] J Am Acad Dermatol. 1999 Sep;41(3 Pt 1):458-9 [10507911.001]
  • [Cites] N Engl J Med. 2000 Apr 6;342(14):1027-38 [10749966.001]
  • [Cites] Epidemiol Infect. 2000 Dec;125(3):671-5 [11218216.001]
  • [Cites] Clin Cancer Res. 2001 Aug;7(8):2263-8 [11489800.001]
  • [Cites] Dermatology. 2004;208(3):255-8 [15118382.001]
  • [Cites] Ann Transplant. 1998;3(1):5-12 [9869891.001]
  • [Cites] Lancet. 1995 Sep 23;346(8978):799-802 [7674745.001]
  • [Cites] Klin Med (Mosk). 1993;71(2):27-30 [8046918.001]
  • [Cites] Acta Oncol. 1996;35(2):193-9 [8639315.001]
  • [Cites] Am J Pathol. 1996 Jun;148(6):2009-16 [8669485.001]
  • [Cites] Verh Dtsch Ges Pathol. 1996;80:318-21 [9065036.001]
  • [Cites] N Engl J Med. 1997 Apr 3;336(14):988-93 [9077377.001]
  • [Cites] Lancet. 1986 Dec 6;2(8519):1309-11 [2878178.001]
  • (PMID = 18565232.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2442120
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49. Bezdekova M, Brychtova S, Sedlakova E, Steigerova J, Hlobilkova A, Bienova M, Kucerova R, Brychta T, Krejci V, Kolar Z: Immunohistochemical assessment of E-cadherin and beta-catenin in trichofolliculomas and trichoepitheliomas. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub; 2007 Dec;151(2):251-5
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  • BACKGROUND: Trichofolliculomas and trichoepitheliomas are benign skin neoplasms originating from hair follicle cells.
  • It is known that the E-cadherin/beta-catenin system of adhesion molecules plays a crucial role in the maintenance of tissue architecture.
  • AIM: The aim of the present study was to investigate their involvement in benign hair follicle tumor development.
  • METHODS: Semiquantitative intensity of expression were examined in formalin-fixed and paraffin-embedded tissue sections of 53 trichoepitheliomas, 15 trichofolliculomas and 19 normal skin samples by indirect immunohistochemistry.
  • RESULTS: The intensity of E-cadherin/beta-catenin expression in tumor cells did not differ from controls.
  • However, normal hair follicles cells exhibited membranous E-cadherin/beta-catenin expression, whereas both types of tumors, particularly trichoepitheliomas, showed E-cadherin/beta-catenin expression with a predominantly cytoplasmic localization.
  • CONCLUSIONS: We suggest that this dystopic distribution of the E-cadherin/beta-catenin complex in hair follicle tumor cells may be a marker of cell-cell adhesion disruption which may contribute to the tumor formation.
  • [MeSH-major] Cadherins / analysis. Hair Diseases / metabolism. Neoplasms, Basal Cell / chemistry. Skin Neoplasms / chemistry. beta Catenin / analysis

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  • (PMID = 18345259.001).
  • [ISSN] 1213-8118
  • [Journal-full-title] Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
  • [ISO-abbreviation] Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Cadherins; 0 / beta Catenin
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50. Merritt BG, Snow SN, Longley BJ: Desmoplastic trichoepithelioma, infiltrative/morpheaform BCC, and microcystic adnexal carcinoma: differentiation by immunohistochemistry and determining the need for Mohs micrographic surgery. Cutis; 2010 May;85(5):254-8
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  • Several important cutaneous neoplasms present with basaloid cells in the dermis.
  • Desmoplastic trichoepithelioma (DTE), infiltrative/morpheaform basal cell carcinoma (BCC), and microcystic adnexal carcinoma (MAC) are tumors in this category that may be difficult to differentiate, especially when evaluating thin biopsy specimens.
  • An accurate diagnosis has important clinical implications.
  • While DTE is a benign neoplasm with indolent behavior, infiltrative/morpheaform BCC and MAC can be highly aggressive, leading to substantial local destruction and potential metastasis.
  • We present a patient with an unusual tumor demonstrating basaloid cells in the dermis and discuss the diagnostic approach for these lesions, emphasizing the potential role of cytokeratin 20 (CK20) in determining the need for Mohs micrographic surgery.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Skin Appendage / pathology. Mohs Surgery. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Keratin-20. Male. Middle Aged. Staining and Labeling

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  • (PMID = 20540416.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-20
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51. Idrees MT, Deligdisch L, Altchek A: Squamous papilloma with hyperpigmentation in the skin graft of the neovagina in Rokitansky syndrome: literature review of benign and malignant lesions of the neovagina. J Pediatr Adolesc Gynecol; 2009 Oct;22(5):e148-55
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  • [Title] Squamous papilloma with hyperpigmentation in the skin graft of the neovagina in Rokitansky syndrome: literature review of benign and malignant lesions of the neovagina.
  • BACKGROUND: It is rare for a benign or malignant neoplasm to develop in a neovagina.
  • CASE: This is the first report of a squamous papilloma with hyperpigmentation which developed in the neovagina 12 years after a McIndoe procedure was done with a split-thickness skin graft from the patient's buttock.
  • Despite the dark color of the vaginal lesion, bleeding and rapid appearance our patient had a benign tumor.
  • [MeSH-major] Papilloma / pathology. Skin Transplantation / pathology. Surgically-Created Structures. Uterus / abnormalities. Vagina / abnormalities. Vagina / surgery

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  • (PMID = 19616457.001).
  • [ISSN] 1873-4332
  • [Journal-full-title] Journal of pediatric and adolescent gynecology
  • [ISO-abbreviation] J Pediatr Adolesc Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 46
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52. Zmonarski SC, Boratyńska M, Puziewicz-Zmonarska A, Kazimierczak K, Klinger M: Kaposi's sarcoma in renal transplant recipients. Ann Transplant; 2005;10(2):59-65
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  • Kaposi's sarcoma (KS) is a spindle-shaped vascular cell tumor that occurs in the skin, lymphoid, respiratory and gastrointestinal tissues.
  • It may resemble aggressive malignant neoplasm in HIV-related or in post-transplant types but classic form may behave as benign, potentially controllable and reversible hyperplasia.
  • 90% of KS cases appear as dark blue or purplish macular lesions that may form nodular tumors.
  • Sirolimus seems to inhibit the growth of established vascularized tumors and this effect is best realized with relatively low immunosuppressive doses of drug.


53. Fiorucci F, Conti V, Lucantoni G, Patrizi A, Fiorucci C, Giannunzio G, Di Michele L: Sarcoidosis of the breast: a rare case report and a review. Eur Rev Med Pharmacol Sci; 2006 Mar-Apr;10(2):47-50
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  • Sarcoidosis is an idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis.
  • It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands.
  • Breast involvement is extremely rare, but, when present, it could be confused with a benign or, more important, a malignant neoplasm.
  • A chest X-ray and a Computed Tomography (CT), with raised serum levels of Angiotensin Converting Enzyme (ACE), were compatible with a diagnosis of sarcoidosis.
  • [MeSH-major] Breast Diseases / diagnosis. Sarcoidosis / diagnosis
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Female. Humans. Mammography. Middle Aged. Tomography, X-Ray Computed. Ultrasonography, Mammary

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  • (PMID = 16705947.001).
  • [ISSN] 1128-3602
  • [Journal-full-title] European review for medical and pharmacological sciences
  • [ISO-abbreviation] Eur Rev Med Pharmacol Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 6
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54. Pouryazdanparast P, Newman M, Mafee M, Haghighat Z, Guitart J, Gerami P: Distinguishing epithelioid blue nevus from blue nevus-like cutaneous melanoma metastasis using fluorescence in situ hybridization. Am J Surg Pathol; 2009 Sep;33(9):1396-400
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  • [Title] Distinguishing epithelioid blue nevus from blue nevus-like cutaneous melanoma metastasis using fluorescence in situ hybridization.
  • Blue nevus (BN)-like cutaneous melanoma metastasis is a well-recognized variant of melanoma metastasis.
  • These lesions may clinically and histologically simulate benign blue nevi.
  • The histologic changes may be indistinguishable from conventional blue nevi or epithelioid blue nevi (EBN), a benign dermal-based melanocytic neoplasm with epithelioid morphology and heavily pigmented cytoplasm.
  • Distinguishing BN-like cutaneous melanoma metastasis from benign conventional or EBN is important for staging and treatment.
  • Ten BN-like cutaneous melanoma metastatic lesions and 10 EBN were blindly evaluated with the above mentioned FISH probes.
  • FISH enumeration and criteria for diagnosis of melanoma was as previously described.
  • Nine of 10 BN-like cutaneous metastatic lesions showed significant aberrations and met previously established criteria for melanoma.
  • None of the EBN cases showed evidence of significant copy number changes or met FISH criteria for a diagnosis of melanoma.
  • FISH is an important diagnostic adjunct for melanocytic neoplasms.
  • The test and the parameters previously established can perform with high sensitivity and specificity when dealing with this differential diagnosis.
  • [MeSH-major] Epithelioid Cells / pathology. In Situ Hybridization, Fluorescence / methods. Melanoma / diagnosis. Nevus, Blue / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chromosome Aberrations. DNA, Neoplasm / analysis. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Young Adult


55. Ardigo M, Buffon RB, Scope A, Cota C, Buccini P, Berardesca E, Pellacani G, Marghoob AA, Gill M: Comparing in vivo reflectance confocal microscopy, dermoscopy, and histology of clear-cell acanthoma. Dermatol Surg; 2009 Jun;35(6):952-9
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  • BACKGROUND: Clear cell acanthoma (CCA) is a rare, benign neoplasm of unknown etiology, whose dermoscopic and histological features have been previously described.
  • In some cases, diagnosis remains uncertain, and histological examination is needed.
  • All lesions were surgically excised to confirm the diagnosis and compare the morphological attributes under light microscopy with in vivo imaging.
  • RCM appears to be a useful tool for in vivo diagnosis of CCA and may help avoid unnecessary biopsies.
  • [MeSH-major] Acanthoma / pathology. Dermoscopy / methods. Histological Techniques / methods. Microscopy, Confocal / methods. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Reproducibility of Results

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  • (PMID = 19397663.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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56. Ma C, Quesnelle KM, Sparano A, Rao S, Park MS, Cohen MA, Wang Y, Samanta M, Kumar MS, Aziz MU, Naylor TL, Weber BL, Fakharzadeh SS, Weinstein GS, Vachani A, Feldman MD, Brose MS: Characterization CSMD1 in a large set of primary lung, head and neck, breast and skin cancer tissues. Cancer Biol Ther; 2009 May;8(10):907-16
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  • [Title] Characterization CSMD1 in a large set of primary lung, head and neck, breast and skin cancer tissues.
  • The Cub and Sushi Multiple Domains-1 (CSMD1) is a tumor suppressor gene on 8p23.2, where allelic loss is both frequent and associated with poor prognosis in head and neck squamous cell carcinoma (HNSCC).
  • To understand the extent of CSMD1 aberrations in vivo, we characterized 184 primary tumors from the head and neck, lung, breast and skin for gene copy number and analyzed expression in our HNSCCs and lung squamous cell carcinomas (SCCs).
  • We detected loss of CSMD1 in a large proportion of HNSCCs (50%), lung (46%) and breast cancers (55%), and to a lesser extent in cutaneous SCCs (29%) and basal cell carcinomas (BCCs, 17%) using array-based comparative genomic hybridization (aCGH).
  • CSMD1 expression was decreased in tumors compared to adjacent benign tissue (65%, 13/20) and was likely due to gene loss in 45% of cases (9/20).
  • We show loss of CSMD1 in primary HNSCC tissues, and document for the first time that CSMD1 is lost in breast, lung and cutaneous SCCs.
  • [MeSH-major] Breast Neoplasms / genetics. Head and Neck Neoplasms / genetics. Lung Neoplasms / genetics. Membrane Proteins / genetics. Skin Neoplasms / genetics
  • [MeSH-minor] Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / pathology. Case-Control Studies. Chromosome Deletion. Comparative Genomic Hybridization. DNA, Neoplasm / analysis. Female. Gene Dosage. Gene Expression. Humans. Loss of Heterozygosity. Mouth Neoplasms / genetics. RNA, Messenger / genetics. RNA, Messenger / metabolism


57. Rosa N, Lanza M, Cennamo G, Accardo M: Pilomatrixoma of the eyelid. J Dermatol Case Rep; 2008 Jul 7;2(2):21-3
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  • BACKGROUND: Pilomatrixoma is a benign tumor of the hair follicle that can transform into a malignant lesion, the pilomatrix carcinoma.
  • Results of both examinations were consistent with a benign pilomatrixoma.
  • CONCLUSIONS: Even though the lesion had malignant clinical appearance, histopathology confirmed the diagnosis of a benign pilomatrixoma, supporting the decision not to make a more extensive surgery.

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  • [Cites] Arch Dermatol. 1961 Apr;83:606-18 [13700704.001]
  • [Cites] J Pediatr Surg. 2006 Oct;41(10):1755-8 [17011283.001]
  • [Cites] Arch Derm Syphilol. 1949 May;59(5):506-18 [18127498.001]
  • [Cites] Arch Ophthalmol. 1983 Aug;101(8):1209-10 [6882248.001]
  • [Cites] Indian J Ophthalmol. 2008 Jan-Feb;56(1):83-4 [18158418.001]
  • [Cites] Ophthal Plast Reconstr Surg. 2008 Jan-Feb;24(1):60-2 [18209650.001]
  • [Cites] Cancer. 1993 Apr 15;71(8):2491-8 [8453573.001]
  • (PMID = 21886706.001).
  • [ISSN] 1898-7249
  • [Journal-full-title] Journal of dermatological case reports
  • [ISO-abbreviation] J Dermatol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Other-IDs] NLM/ PMC3157770
  • [Keywords] NOTNLM ; eyelid / pilomatrixoma / skin neoplasm
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58. Nino M, Brunetti B, Delfino S, Brunetti B, Panariello L, Russo D: Spitz nevus: follow-up study of 8 cases of childhood starburst type and proposal for management. Dermatology; 2009;218(1):48-51
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  • Spitz nevus is an uncommon, benign melanocytic neoplasm that shares many clinical and histological features with melanoma.
  • It presents clinical ambiguity that makes the diagnosis and management of the patient difficult.
  • [MeSH-major] Dermoscopy. Nevus, Epithelioid and Spindle Cell / pathology. Skin Neoplasms / pathology


59. Ghazali N, Cascarini L, Norris P, Barrett AW, Lavery KM: Perivascular epithelioid cell tumor (PEComa) of the cheek. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Jul;110(1):e26-31
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  • [Title] Perivascular epithelioid cell tumor (PEComa) of the cheek.
  • We present the unusual case of a perivascular epithelioid cell tumor (PEComa) occurring within the cheek of a 32-year-old woman.
  • PEComa is a rare, recently described, family of tumors with diverse clinicopathologic expression and which express melanocytic and muscle markers.
  • It mainly affects the abdominopelvic region and rarely occurs in somatic soft tissue or skin.
  • To our knowledge, this is the first reported case of PEComa occurring in the facial cutaneous tissues.
  • Other possible diagnoses considered included benign mesenchymal tumors of smooth muscle or neural origin.
  • The tumor was completely excised, but in view of uncertainty as to how this entity would behave in an unusual location, lifelong follow up is recommended.
  • [MeSH-major] Cheek / pathology. Facial Neoplasms / diagnosis. Perivascular Epithelioid Cell Neoplasms / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Actins / analysis. Adult. Antigens, Neoplasm / analysis. Arterioles / pathology. Diagnosis, Differential. Epithelioid Cells / pathology. Female. Follow-Up Studies. Humans. MART-1 Antigen. Muscle, Smooth, Vascular / pathology. Neoplasm Proteins / analysis

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  • [Copyright] Copyright (c) 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20610292.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Neoplasm Proteins
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60. Kim UR, Arora V, Shanti R, Shah AD: Neglected giant atypical fibroxanthoma of the eyelid. Ophthal Plast Reconstr Surg; 2009 Sep-Oct;25(5):408-9
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  • Atypical fibroxanthoma is an uncommon neoplasm of the superficial soft tissue that occurs in actinically damaged skin of elderly patients.
  • [MeSH-major] Eyelid Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology

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  • (PMID = 19966663.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Taube JM, Begum S, Shi C, Eshleman JR, Westra WH: Benign nodal nevi frequently harbor the activating V600E BRAF mutation. Am J Surg Pathol; 2009 Apr;33(4):568-71
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  • [Title] Benign nodal nevi frequently harbor the activating V600E BRAF mutation.
  • Mutational activation of the BRAF oncogene is the most common genetic alteration in cutaneous melanoma.
  • Nodal nevi are small aggregates of benign nevus cells that are commonly encountered in the SLNs of patients with melanoma.
  • Novel strategies that rely on detection of putative melanoma-specific markers for the diagnosis of micrometastatic melanoma in SLNs need to take into account the molecular genetic profile of the benign nodal nevus.
  • [MeSH-major] Lymph Nodes / pathology. Melanoma / diagnosis. Mutation, Missense. Nevus / diagnosis. Proto-Oncogene Proteins B-raf / genetics. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. DNA Mutational Analysis. DNA, Neoplasm / analysis. Female. Humans. Male. Middle Aged. Young Adult


62. Saikali S, Paumier V, Garrelon JL, Le Gall F: [Facial primary cutaneous ganglioneuroma]. Ann Pathol; 2009 Apr;29(2):138-41
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  • [Title] [Facial primary cutaneous ganglioneuroma].
  • [Transliterated title] Ganglioneurome cutané primitif de la face.
  • Ganglioneuroma is a benign neoplasm of the sympathetic nervous system most often arising in the posterior mediastinum, retroperitoneum, adrenal medulla and pelvis.
  • The occurrence of ganglioneuroma in the skin is rare with only 10 cases reported in the literature.
  • [MeSH-major] Ganglioneuroma / pathology. Skin Neoplasms / pathology

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  • (PMID = 19364589.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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63. Stegmeier F, Sowa ME, Nalepa G, Gygi SP, Harper JW, Elledge SJ: The tumor suppressor CYLD regulates entry into mitosis. Proc Natl Acad Sci U S A; 2007 May 22;104(21):8869-74
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  • [Title] The tumor suppressor CYLD regulates entry into mitosis.
  • Mutations in the cylindromatosis (CYLD) gene cause benign tumors of skin appendages, referred to as cylindromas.
  • The dysregulation of NF-kappaB activity has been proposed to promote cell transformation in part by increasing apoptosis resistance, but it is not clear whether this is CYLD's only or predominant tumor-suppressing function.
  • Our findings raise the possibility that, as with other genes regulating tumorigenesis, CYLD has not only tumor-suppressing (apoptosis regulation) but also tumor-promoting activities (enhancer of mitotic entry).
  • We propose that this additional function of CYLD could provide an explanation for the benign nature of most cylindroma lesions.
  • [MeSH-major] Mitosis. Tumor Suppressor Proteins / metabolism

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  • [Cites] Nat Genet. 2000 Jun;25(2):160-5 [10835629.001]
  • [Cites] Nat Rev Mol Cell Biol. 2004 Jun;5(6):429-40 [15173822.001]
  • [Cites] Curr Opin Cell Biol. 2000 Dec;12(6):658-65 [11063929.001]
  • [Cites] Cell Growth Differ. 2000 Dec;11(12):615-23 [11149596.001]
  • [Cites] Mol Biol Cell. 2001 Jun;12(6):1791-9 [11408585.001]
  • [Cites] J Cell Biol. 2002 Jan 21;156(2):249-59 [11807090.001]
  • [Cites] Annu Rev Genet. 2002;36:617-56 [12429704.001]
  • [Cites] Nat Cell Biol. 2003 Apr;5(4):346-51 [12629549.001]
  • [Cites] Nat Cell Biol. 2003 Jun;5(6):545-51 [12766774.001]
  • [Cites] Nature. 2003 Aug 14;424(6950):793-6 [12917689.001]
  • [Cites] Nature. 2003 Aug 14;424(6950):797-801 [12917690.001]
  • [Cites] Nature. 2003 Aug 14;424(6950):801-5 [12917691.001]
  • [Cites] Curr Opin Cell Biol. 2004 Apr;16(2):119-26 [15196553.001]
  • [Cites] Chromosoma. 2004 Nov;113(5):211-22 [15351889.001]
  • [Cites] Cell. 1991 Mar 8;64(5):903-14 [1825803.001]
  • [Cites] Trends Biochem Sci. 1993 Mar;18(3):82-3 [8480366.001]
  • [Cites] J Med Genet. 1994 Apr;31(4):321-4 [8071959.001]
  • [Cites] Curr Opin Cell Biol. 1994 Dec;6(6):877-82 [7880537.001]
  • [Cites] Curr Opin Genet Dev. 1995 Feb;5(1):5-11 [7749325.001]
  • [Cites] Science. 1996 Sep 6;273(5280):1377-80 [8703070.001]
  • [Cites] Science. 1996 Dec 6;274(5293):1643-5 [8984634.001]
  • [Cites] Biochem Biophys Res Commun. 1997 Oct 20;239(2):377-85 [9344838.001]
  • [Cites] J Cell Sci. 1998 Jun;111 ( Pt 12):1751-7 [9601104.001]
  • [Cites] Science. 1998 Nov 27;282(5394):1701-4 [9831560.001]
  • [Cites] Curr Opin Cell Biol. 2004 Dec;16(6):623-8 [15530772.001]
  • [Cites] Nature. 2004 Nov 18;432(7015):316-23 [15549093.001]
  • [Cites] Mol Biol Cell. 2004 Dec;15(12):5623-34 [15469984.001]
  • [Cites] J Biol Chem. 2004 Dec 31;279(53):55161-7 [15496400.001]
  • [Cites] Science. 2005 Dec 2;310(5753):1499-504 [16322459.001]
  • [Cites] J Biol Chem. 2005 Dec 9;280(49):41111-21 [16230348.001]
  • [Cites] Trends Cell Biol. 2006 Jan;16(1):55-63 [16337124.001]
  • [Cites] Cell. 2006 May 19;125(4):665-77 [16713561.001]
  • [Cites] Nature. 2007 Apr 19;446(7138):876-81 [17443180.001]
  • [Cites] Nat Cell Biol. 2007 May;9(5):556-64 [17417629.001]
  • [Cites] Oncogene. 2003 Oct 16;22(46):7101-7 [14562038.001]
  • [Cites] Proc Natl Acad Sci U S A. 2004 May 25;101(21):7937-42 [15148369.001]
  • [Cites] Nature. 2000 Jul 27;406(6794):430-5 [10935642.001]
  • (PMID = 17495026.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Grant] United States / NIA NIH HHS / AG / R01 AG011085
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / NF-kappa B; 0 / Tumor Suppressor Proteins; 0 / ets-Domain Protein Elk-1
  • [Other-IDs] NLM/ PMC1867381
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64. Vereecken P, Debray C, Petein M, Awada A, Lalmand MC, Laporte M, Van Den Heule B, Verhest A, Pochet R, Heenen M: Expression of galectin-3 in primary and metastatic melanoma: immunohistochemical studies on human lesions and nude mice xenograft tumors. Arch Dermatol Res; 2005 Feb;296(8):353-8
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  • [Title] Expression of galectin-3 in primary and metastatic melanoma: immunohistochemical studies on human lesions and nude mice xenograft tumors.
  • To study the possible correlation between Gal-3 expression and malignant potential in primary melanoma lesions, we conducted an immunohistochemical study with monoclonal anti-Gal-3 antibody in a series of primary and metastatic melanoma lesions as well as benign skin pigmented lesions.
  • The expression of Gal-3 was higher in thin primary melanoma lesions than in benign pigmented skin lesions or metastases and seemed to correlate inversely with the aggressiveness as estimated by the Breslow index which is recognized as the main prognostic factor in melanoma.
  • [MeSH-minor] Animals. Blotting, Western. Humans. Immunohistochemistry. Mice. Mice, Nude. Neoplasm Transplantation. Nevus / metabolism. Transplantation, Heterologous

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  • (PMID = 15645276.001).
  • [ISSN] 0340-3696
  • [Journal-full-title] Archives of dermatological research
  • [ISO-abbreviation] Arch. Dermatol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Galectin 3
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65. Parreira LM, Sípoli JM, Mercante AM, Orfali RL, Levites J: Case for diagnosis: (unilateral multiple piloleiomyoma). An Bras Dermatol; 2009 Mar-Apr;84(2):197-9
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  • [Title] Case for diagnosis: (unilateral multiple piloleiomyoma).
  • Piloleiomyoma is a benign neoplasm arising from the erector pilorum muscle in the skin.
  • [MeSH-major] Leiomyomatosis / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Antipruritics / administration & dosage. Breast Neoplasms / drug therapy. Breast Neoplasms / pathology. Female. Humans. Hydroxyzine / administration & dosage. Muscle, Smooth / pathology. Pain / diagnosis. Young Adult

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  • (PMID = 19503991.001).
  • [ISSN] 1806-4841
  • [Journal-full-title] Anais brasileiros de dermatologia
  • [ISO-abbreviation] An Bras Dermatol
  • [Language] eng; por
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Antipruritics; 30S50YM8OG / Hydroxyzine
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66. Shehan JM, Huerter CJ: Desmoplastic trichoepithelioma: report of a case illustrating its natural history. Cutis; 2008 Mar;81(3):236-8
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  • First described more than 30 years ago, desmoplastic trichoepithelioma is a rare but benign adnexal neoplasm.
  • Though the tumors are benign, the possibility of malignant neoplasm may spark both clinical and histologic concern.
  • A full-thickness skin biopsy is advisable when desmoplastic trichoepithelioma is suspected.
  • A patient's clinical history may provide some clues to help guide diagnosis, as the tumors may be present for years and slow growth is commonly reported.
  • We present a patient with desmoplastic trichoepithelioma that uniquely documents and supports the typical natural history of this tumor, as demonstrated by annual school photographs.
  • [MeSH-major] Facial Neoplasms / diagnosis. Neoplasms, Adnexal and Skin Appendage / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Photomicrography. Rare Diseases

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  • (PMID = 18441846.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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67. Gerami P, Barnhill RL, Beilfuss BA, LeBoit P, Schneider P, Guitart J: Superficial melanocytic neoplasms with pagetoid melanocytosis: a study of interobserver concordance and correlation with FISH. Am J Surg Pathol; 2010 Jun;34(6):816-21
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  • [Title] Superficial melanocytic neoplasms with pagetoid melanocytosis: a study of interobserver concordance and correlation with FISH.
  • Pagetoid proliferation of single melanocytic cells or small nests of melanocytes may be seen in a variety of melanocytic neoplasms including pagetoid spitz nevi, de novo epithelioid melanocytic dysplasia, and melanoma.
  • In this study, we collected 24 cases of superficial melanocytic neoplasms with prominent pagetoid melanocytosis.
  • We allowed 3 experienced consultant dermatopathologists to independently evaluate these entities and score them from 1 to 4, with 1 being totally benign and 4 being melanoma.
  • We found strong interobserver reliability in the diagnosis in 71% of cases, whereas 29% showed considerable discordance.
  • We found that FISH accurately identified as malignant 5 of 7 cases which had a consensus diagnosis of melanoma.
  • None of the cases with a consensus diagnosis of benign were FISH positive.
  • There is considerable discordance in superficial melanocytic neoplasm with prominent pagetoid melanocytosis even among expert consultants.
  • [MeSH-major] Melanoma / diagnosis. Melanoma / genetics. Precancerous Conditions / diagnosis. Skin Neoplasms / diagnosis. Skin Neoplasms / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Nevus, Epithelioid and Spindle Cell / diagnosis. Nevus, Epithelioid and Spindle Cell / epidemiology. Nevus, Epithelioid and Spindle Cell / genetics. Observer Variation. Young Adult


68. De Queiroz GF, Matera JM, Zaidan Dagli ML: Clinical study of cryosurgery efficacy in the treatment of skin and subcutaneous tumors in dogs and cats. Vet Surg; 2008 Jul;37(5):438-43
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  • [Title] Clinical study of cryosurgery efficacy in the treatment of skin and subcutaneous tumors in dogs and cats.
  • OBJECTIVE: To evaluate the efficacy of cryosurgery for treatment of skin and subcutaneous tumors in dogs and cats.
  • METHODS: Cutaneous or subcutaneous tumors were treated by liquid nitrogen cryosurgical spray (1 cm from target tissue at 90 degrees until a 5-mm halo of frozen tissue was achieved) for 15-60 seconds.
  • Malignant lesions had 3 freeze-thaw cycles benign tumors, 2 cycles.
  • RESULTS: Tumor size ranged from 0.3 to 11 cm diameter with 28 (60%) being 0.3-1 cm; 8 (17%) 1.1-3 cm, and 11 (23%) >3.4 cm.
  • One malignant peripheral nerve sheath tumor recurred 7 months after cryosurgical treatment.
  • CONCLUSION: Cryosurgery is an efficient method for treatment of skin and subcutaneous tumors in dogs and cats.
  • CLINICAL RELEVANCE: Cryosurgical ablation is an effective means of treating small cutaneous or subcutaneous tumors in dogs and cats, especially in older animals where wound closure or cosmetic outcome might limit surgical excision alone.
  • [MeSH-major] Cat Diseases / surgery. Cryosurgery / veterinary. Dog Diseases / surgery. Skin Neoplasms / veterinary. Wound Healing / physiology
  • [MeSH-minor] Animals. Cats. Dogs. Female. Male. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / veterinary. Prospective Studies. Remission Induction. Treatment Outcome

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  • (PMID = 18986310.001).
  • [ISSN] 1532-950X
  • [Journal-full-title] Veterinary surgery : VS
  • [ISO-abbreviation] Vet Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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69. Gatti A, di Meo N, Trevisan G: Dermoscopy of eccrine acrospiroma masquerading as nodular malignant melanoma. Acta Dermatovenerol Alp Pannonica Adriat; 2010 Dec;19(4):23-5
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  • Eccrine acrospiroma, better known as eccrine poroma, is a benign adnexal neoplasm of the skin.
  • [MeSH-major] Acrospiroma / pathology. Dermoscopy. Melanoma / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male


70. Baumhoer D, Pförtner R, Mohr C, Jundt G: Tubulopapillary hidradenoma-like tumor of the mandible. Int J Oral Maxillofac Surg; 2009 Aug;38(8):903-7
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  • [Title] Tubulopapillary hidradenoma-like tumor of the mandible.
  • Tubulopapillary hidradenomas are uncommon benign tumors of the dermis, most commonly occurring in the skin of the head or of the extremities.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Mandibular Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Curettage. Diagnosis, Differential. Epithelial Cells / pathology. Follow-Up Studies. Humans. Jaw Cysts / diagnosis. Male. Mandible / surgery. Mandibular Diseases / diagnosis. Neoplasm Recurrence, Local / pathology. Osteolysis / diagnosis. Osteotomy

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  • (PMID = 19375892.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
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71. Laga AC, Tajirian AL, Islam MN, Bhattacharyya I, Cohen DM, Plamondon CJ, Robinson-Bostom L: Myopericytoma: report of two cases associated with trauma. J Cutan Pathol; 2008 Sep;35(9):866-70
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  • Myopericytoma is a rare, recently described tumor demonstrating a hemangiopericytoma-like vascular pattern.
  • Despite sharing morphologic features with angioleiomyoma, myofibroma and glomus tumor, myopericytoma is thought to represent a distinct perivascular myoid neoplasm of skin and soft tissues.
  • The tumor is characterized by a radial and perivascular arrangement of ovoid, spindled to round neoplastic cells that are immunoreactive to alpha-smooth muscle actin, often for h-caldesmon as well as smooth muscle myosin-heavy chain, and usually negative for desmin antibodies.
  • Most cases of myopericytoma are benign, however, local recurrence and malignancy have recently been reported, Myopericytoma can be multifocal involving a single or multiple anatomic regions, and tends to occur in dermal and superficial soft tissues of adults primarily on the extremities.
  • [MeSH-major] Hemangiopericytoma / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology. Wounds and Injuries / complications
  • [MeSH-minor] Actins / metabolism. Aged. Biomarkers, Tumor / metabolism. Calcium-Binding Proteins / metabolism. Female. Humans. Male. Microfilament Proteins / metabolism. Middle Aged. Mouth Mucosa / injuries. Myosin Heavy Chains / metabolism. Nose / injuries. Treatment Outcome

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  • (PMID = 18494828.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Calcium-Binding Proteins; 0 / Microfilament Proteins; 0 / calponin; EC 3.6.4.1 / Myosin Heavy Chains
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72. Sidoroff A: [Epidemiology of cutaneous vascular neoplasms and malformations in childhood]. Handchir Mikrochir Plast Chir; 2009 Apr;41(2):65-9
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  • [Title] [Epidemiology of cutaneous vascular neoplasms and malformations in childhood].
  • PURPOSE: A representative compilation of data on the incidence and prevalence of benign cutaneous vascular neoplasms and malformations in childhood has been made.
  • [MeSH-major] Arteriovenous Malformations / epidemiology. Hemangioma / epidemiology. Skin / blood supply. Skin Neoplasms / epidemiology. Soft Tissue Neoplasms / epidemiology
  • [MeSH-minor] Age Factors. Austria. Child. Child, Preschool. Cohort Studies. Cross-Sectional Studies. Health Surveys. Hemangioma, Capillary / epidemiology. Hemangioma, Cavernous / epidemiology. Humans. Incidence. Infant. Infant, Newborn. Infant, Premature, Diseases / epidemiology. Neoplasm Regression, Spontaneous. Port-Wine Stain / epidemiology

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  • (PMID = 19180424.001).
  • [ISSN] 1439-3980
  • [Journal-full-title] Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der Peripheren Nerven und Gefässe : Organ der Vereinigung der Deutschen Plastischen Chirurgen
  • [ISO-abbreviation] Handchir Mikrochir Plast Chir
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 39
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73. Singh RS, Diwan AH, Zhang PS, Prieto VG: Phosphoinositide 3-kinase is not overexpressed in melanocytic lesions. J Cutan Pathol; 2007 Mar;34(3):220-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To investigate the expression pattern of PI3K in benign and dysplastic nevi, primary melanomas, and metastatic melanomas and the role of PTEN and PI3K in melanocytic tumor progression.
  • METHODS: Tissue microarrays were constructed using formalin-fixed, paraffin-embedded archival tissue blocks from 89 melanocytic lesions: 17 benign nevi, 18 dysplastic nevi, 23 primary melanomas, and 31 metastatic melanomas.
  • RESULTS: Both benign and dysplastic nevi showed strong cytoplasmic staining with PTEN, which was subsequently less in melanomas and completely lost in the metastatic lesions.
  • Eleven of 17 (64%) benign nevi, seven of 10 (70%) dysplastic nevi, four of 23 (17%) primaries, and one of 31 (3%) visceral or lymph node metastasis showed strong positivity.
  • Loss of PTEN expression from benign and dysplastic nevi to melanoma was statistically significant (p=0.001).
  • Although few cells showed reactivity for phosphoinositide 3-kinase (PI3 kinase)-p85 subunit, strong positivity was not detected in the cytoplasm of benign, malignant, or metastatic lesions, except for a single visceral metastasis.
  • There was no statistical difference in PI3 kinase expression in benign and malignant melanocytic lesions (p=0.2).
  • [MeSH-major] Dysplastic Nevus Syndrome / enzymology. Melanoma / enzymology. Phosphatidylinositol 3-Kinases / metabolism. Skin Neoplasms / enzymology
  • [MeSH-minor] Humans. Immunohistochemistry. Neoplasm Metastasis. PTEN Phosphohydrolase / metabolism. Tissue Array Analysis

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  • (PMID = 17302605.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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74. Ares E: An uncommon skin condition illustrates the need for caution when prescribing for friends. J Am Acad Nurse Pract; 2008 Aug;20(8):389-95
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  • [Title] An uncommon skin condition illustrates the need for caution when prescribing for friends.
  • DATA SOURCES: A review of the prescribing practices of clinicians, the cognitive processes needed in diagnosis and treatment, the current ethical guidelines, and a review of MF, its course, and treatments.
  • CONCLUSIONS: Treating acquaintances and family informally places clinicians at risk for liability and patients at risk for inaccurate diagnosis and treatment.
  • This case illustrates the potential hazard of casually treating a friend for what looks like a benign condition.
  • Resembling atopic dermatitis in its early stages, MF is the most common of a rare group of skin lymphomas.
  • Early diagnosis and treatment are crucial for a better prognosis.
  • Had this clinician complied with the request of her friend, his diagnosis would have been missed and timely treatment delayed.
  • [MeSH-major] Diagnostic Errors / prevention & control. Drug Prescriptions / nursing. Friends. Mycosis Fungoides / diagnosis. Nurse Practitioners / organization & administration. Professional Autonomy
  • [MeSH-minor] Biopsy. Dermatitis, Atopic / drug therapy. Dermatitis, Atopic / nursing. Diagnosis, Differential. Early Diagnosis. Family. Humans. Liability, Legal. Male. Malpractice / legislation & jurisprudence. Neoplasm Staging. Nursing Assessment. Physical Examination. Practice Guidelines as Topic. Prognosis. Rare Diseases

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  • (PMID = 18786012.001).
  • [ISSN] 1745-7599
  • [Journal-full-title] Journal of the American Academy of Nurse Practitioners
  • [ISO-abbreviation] J Am Acad Nurse Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 34
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75. Urquhart JL, Uzieblo A, Kohler S: Detection of HHV-8 in pyogenic granuloma-like Kaposi sarcoma. Am J Dermatopathol; 2006 Aug;28(4):317-21
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  • Kaposi sarcoma (KS) is a low-grade vascular neoplasm associated with human herpesvirus-8 (HHV-8) infection.
  • Recently, we encountered 6 KS tumors that histologically mimicked pyogenic granuloma (PG), a common benign vascular tumor of the skin that usually does not figure in the histologic differential diagnosis of KS.
  • [MeSH-major] Granuloma, Pyogenic / pathology. Herpesvirus 8, Human / isolation & purification. Sarcoma, Kaposi / diagnosis. Sarcoma, Kaposi / virology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, Viral / metabolism. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Nuclear Proteins / metabolism. Phosphoproteins / metabolism

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  • (PMID = 16871034.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Viral; 0 / Nuclear Proteins; 0 / Phosphoproteins; 0 / latent nuclear antigen (LNA)
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76. Teichman JM, Sea J, Thompson IM, Elston DM: Noninfectious penile lesions. Am Fam Physician; 2010 Jan 15;81(2):167-74
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  • Family physicians commonly diagnose and manage penile cutaneous lesions.
  • The clinical presentation and appearance of the lesions guide the diagnosis.
  • Some benign lesions, such as psoriasis and lichen planus, can mimic carcinoma in situ or squamous cell carcinoma.
  • Biopsy is indicated if the diagnosis is in doubt or neoplasm cannot be excluded.
  • The management of benign penile lesions usually involves observation or topical corticosteroids; however, neoplastic lesions generally require surgery.
  • [MeSH-major] Penile Diseases / classification. Penile Diseases / diagnosis. Practice Guidelines as Topic. Skin Diseases, Infectious / diagnosis
  • [MeSH-minor] Adult. Aged. Balanitis / diagnosis. Humans. Male. Middle Aged. Penile Neoplasms / diagnosis. Practice Patterns, Physicians'. Skin Diseases / diagnosis. Skin Diseases, Parasitic / diagnosis. Skin Diseases, Viral / diagnosis. Young Adult

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  • (PMID = 20082512.001).
  • [ISSN] 1532-0650
  • [Journal-full-title] American family physician
  • [ISO-abbreviation] Am Fam Physician
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 49
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77. Hsiao PF, Hsiao CH, Lin YC, Tseng MP, Tsai TF, Jee SH: Histopathologic-molecular correlation in early mycosis fungoides using T-cell receptor gamma gene rearrangement by polymerase chain reaction with laser capture microdissection. J Formos Med Assoc; 2007 Apr;106(4):265-72
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  • BACKGROUND/PURPOSE: Early mycosis fungoides (MF) is difficult to distinguish from other benign inflammatory dermatoses.
  • We evaluated clonal T-cell receptor (TCR) gamma gene rearrangement by polymerase chain reaction (PCR) as a surrogate to histologic diagnosis in early MF.
  • METHODS: Twenty paraffin-embedded skin biopsies from nine patients diagnosed with MF were included.
  • RESULTS: TCRgamma PCR was positive in 53% (8/15) of the patch stage, in 100% (2/2) of the plaque stage, and in 100% (3/3) of the tumor stage.
  • CONCLUSION: TCRgamma PCR allows the diagnosis of MF in patients with lymphocyte-poor lesions, suggestive of MF pathologically.
  • We suggest that the ratio of malignant clonal to reactive T-cells is critical for MF diagnosis.

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  • (PMID = 17475602.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Singapore
  • [Chemical-registry-number] 0 / DNA Primers; 0 / DNA, Neoplasm
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78. Fujii H, Jiang W, Matsumoto T, Miyai K, Sashara K, Ohtsuji N, Hino O: Birt-Hogg-Dubé gene mutations in human endometrial carcinomas with microsatellite instability. J Pathol; 2006 Jul;209(3):328-35
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  • Birt-Hogg-Dubé (BHD) syndrome is a rare form of autosomal dominantly inherited genodermatosis characterized by benign hamartomatous skin lesions named fibrofolliculomas, and an increased risk for developing pulmonary cyst/pneumothorax and various forms of renal cell carcinoma.
  • Of these, one showed additional mutation in exon 4, possibly satisfying the two-hit hypothesis of tumour suppressor genes.
  • When multiple foci were microdissected and individually screened for mutation, BHD mutations were shown to have been acquired during tumour progression, after mutation of the BAX gene, in three of five cases.
  • [MeSH-major] Endometrial Neoplasms / genetics. Microsatellite Repeats / genetics. Mutation. Neoplastic Syndromes, Hereditary / genetics. Proteins / genetics. Proto-Oncogene Proteins / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Adult. Aged. Aged, 80 and over. Base Sequence. Carrier Proteins / genetics. DNA Methylation. DNA-Binding Proteins / genetics. Disease Progression. Female. Humans. Microdissection / methods. Middle Aged. Molecular Sequence Data. Neoplasm Proteins / genetics. Nuclear Proteins / genetics. bcl-2-Associated X Protein / genetics

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  • [Copyright] Copyright (c) 2006 Pathological Society of Great Britain and Ireland.
  • (PMID = 16691634.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / DNA-Binding Proteins; 0 / FLCN protein, human; 0 / G-T mismatch-binding protein; 0 / MLH1 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Proteins; 0 / Proto-Oncogene Proteins; 0 / Tumor Suppressor Proteins; 0 / bcl-2-Associated X Protein
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79. Walsh SN, Sangüeza OP: PEComas: a review with emphasis on cutaneous lesions. Semin Diagn Pathol; 2009 Aug;26(3):123-30
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  • [Title] PEComas: a review with emphasis on cutaneous lesions.
  • The connection between angiomyolipoma (AML) of the kidney, clear cell sugar tumor (CCST) of the lung, and pulmonary lymphangioleiomyoma (LAM), was progressively discovered because of the histologic and immunophenotypic similarities between the three tumors and their frequent association with tuberous sclerosis complex (TSC).
  • PEC tumors (or PEComas), other than AML, CCST, and LAM, are not associated with TSC and typically occur in middle-aged adult females.
  • These neoplasms are composed of nests and fascicles of clear to granular epithelioid and/or spindled cells with a consistent arrangement around blood vessels.
  • Although the most common sites are the gastrointestinal and genitourinary tracts, approximately 23 cases, to date, of PEComas arising in the skin have been reported.
  • Primary cutaneous PEComas also have a predilection for adult females and most often present as a painless mass on the extremities.
  • In contrast to other sites, the myogenic marker most commonly expressed in PEComas of the skin is desmin.
  • Most reported cutaneous PEComas follow a benign course, however, a malignant case has been reported.
  • [MeSH-major] Desmin / metabolism. Epithelioid Cells / pathology. Perivascular Epithelioid Cell Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Actins / metabolism. Antigens, Neoplasm / metabolism. Biomarkers, Tumor / metabolism. Female. Humans. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / metabolism

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  • [CommentIn] Am J Dermatopathol. 2016 Feb;38(2):165-6 [26825164.001]
  • (PMID = 20043511.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Desmin; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
  • [Number-of-references] 65
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80. Mentzel T, Kutzner H: Dermatomyofibroma: clinicopathologic and immunohistochemical analysis of 56 cases and reappraisal of a rare and distinct cutaneous neoplasm. Am J Dermatopathol; 2009 Feb;31(1):44-9
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  • [Title] Dermatomyofibroma: clinicopathologic and immunohistochemical analysis of 56 cases and reappraisal of a rare and distinct cutaneous neoplasm.
  • Dermatomyofibroma represents a rare and distinct benign cutaneous mesenchymal neoplasm of fibroblastic/myofibroblastic differentiation.
  • The shoulder (13 cases) was the anatomic site most commonly affected, followed by the upper arm (7 cases), the neck (6 cases), the thigh (6 cases), the chest wall (4 cases), the back (3 cases), the axillary fold (2 cases), the abdominal wall (2 cases), and 1 case each was seen on the forearm, the buttock, and the popliteal fossa (exact anatomic location was unknown in 10 cases).
  • Histologically, an ill-defined, plaque-like dermal neoplasm of varying cellularity was seen in all cases, composed of bland spindle-shaped tumor cells often oriented parallel to the overlying epidermis.
  • Immunohistochemically, tumor cells in 11 of 48 cases tested stained positively for alpha-smooth muscle actin, and a focal expression of this marker was noted in 20 cases.
  • Dermatomyofibroma represents a benign fibroblastic/myofibroblastic dermal neoplasm.
  • [MeSH-major] Histiocytoma, Benign Fibrous / metabolism. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / metabolism. Skin Neoplasms / pathology

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  • (PMID = 19155724.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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81. De Felice B, Wilson RR, Nacca M: Telomere shortening may be associated with human keloids. BMC Med Genet; 2009;10:110
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  • BACKGROUND: Keloids are benign skin tumors that are the effect of a dysregulated wound-healing process in genetically predisposed patients.
  • METHODS: We analyzed sample tissues were obtained from 20 patients with keloid skin lesions and normal skin was obtained from 20 healthy donors.
  • Using Terminal Restriction Fragment (TRF) analysis and Real-Time PCR assay, we detected a significant telomere shortening of 30% in keloid specimens compared to normal skin.
  • Moreover, an increase in ROS generation was detected in fibroblasts cell cultures from keloid specimens as more time elapsed compared to fibroblasts from normal skin.
  • Here we found increased ROS generation in fibroblasts from keloid fibroblasts cell cultures when compared to normal skin fibroblasts.

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  • [Cites] Ann N Y Acad Sci. 2000 Jun;908:99-110 [10911951.001]
  • [Cites] Mol Cell Biochem. 2009 Jul;327(1-2):191-201 [19224335.001]
  • [Cites] Crit Rev Oncol Hematol. 2002 Jan;41(1):29-40 [11796230.001]
  • [Cites] Nucleic Acids Res. 2002 May 15;30(10):e47 [12000852.001]
  • [Cites] Genes Chromosomes Cancer. 2002 Jul;34(3):269-75 [12007187.001]
  • [Cites] Trends Biochem Sci. 2002 Jul;27(7):339-44 [12114022.001]
  • [Cites] Hum Mol Genet. 2003 Feb 1;12(3):227-32 [12554677.001]
  • [Cites] Intern Med. 2003 Feb;42(2):150-3 [12636233.001]
  • [Cites] Arterioscler Thromb Vasc Biol. 2003 May 1;23(5):842-6 [12649083.001]
  • [Cites] Mol Cell Biol. 2003 Jul;23(13):4598-610 [12808100.001]
  • [Cites] Circ Res. 2004 Mar 19;94(5):575-84 [15031270.001]
  • [Cites] Circ Res. 2004 Apr 2;94(6):768-75 [14963003.001]
  • [Cites] Hypertens Res. 2004 May;27(5):319-25 [15198478.001]
  • [Cites] Am J Hum Genet. 1993 Apr;52(4):661-7 [8460632.001]
  • [Cites] Am J Pathol. 1994 Jul;145(1):105-13 [8030742.001]
  • [Cites] Science. 1995 Sep 1;269(5228):1236-41 [7544491.001]
  • [Cites] Hum Mol Genet. 1997 Jun;6(6):905-8 [9175737.001]
  • [Cites] Carcinogenesis. 2005 May;26(5):867-74 [15471900.001]
  • [Cites] J Dtsch Dermatol Ges. 2004 Nov;2(11):905-13 [16281608.001]
  • [Cites] Diabetes Care. 2006 Feb;29(2):283-9 [16443874.001]
  • [Cites] Aging Cell. 2006 Aug;5(4):325-30 [16913878.001]
  • [Cites] J Cell Sci. 2008 Apr 1;121(Pt 7):1046-53 [18334557.001]
  • [Cites] Br J Haematol. 2008 Jul;142(1):82-93 [18477050.001]
  • [Cites] Neoplasia. 2008 Oct;10(10):1131-7 [18813352.001]
  • [Cites] Plast Reconstr Surg. 2001 Mar;107(3):797-808 [11304607.001]
  • (PMID = 19863817.001).
  • [ISSN] 1471-2350
  • [Journal-full-title] BMC medical genetics
  • [ISO-abbreviation] BMC Med. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Reactive Oxygen Species; EC 2.7.7.49 / Telomerase
  • [Other-IDs] NLM/ PMC2774319
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82. Zyrek-Betts J, Micale M, Lineen A, Chaudhuri PK, Keil S, Xue J, Thomas JE: Malignant blue nevus with lymph node metastases. J Cutan Pathol; 2008 Jul;35(7):651-7
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  • METHODS: We present a patient with metastatic malignant blue nevus and studies on the histopathologic, immunohistochemical, and molecular features of the neoplasm.
  • Molecular loss of heterozygosity analysis showed different allelic patterns at the hOGG-1 locus between the melanoma and control skin specimens with a varying heterozygous allelic pattern in both the benign and malignant blue nevus.
  • Further study is needed to determine if hOGG-1 mutation or c-kit upregulation play a role in the pathogenesis of dendritic melanocytic lesions (either benign or malignant).
  • [MeSH-major] DNA Glycosylases / genetics. Ki-67 Antigen / metabolism. Loss of Heterozygosity. Nevus, Blue. Proto-Oncogene Proteins c-kit / metabolism. Skin Neoplasms
  • [MeSH-minor] Aged. Humans. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Melanoma / genetics. Polymerase Chain Reaction. Scalp / pathology. Skin / pathology. Up-Regulation

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  • (PMID = 17976211.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Ki-67 Antigen; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / oxoguanine glycosylase 1, human
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83. Miracco C, De Nisi MC, Arcuri F, Cosci E, Pacenti L, Toscano M, Lalinga AV, Biagioli M, Rubegni P, Vatti R, Maellaro E, Del Bello B, Massi D, Luzi P, Tosi P: Macrophage migration inhibitory factor protein and mRNA expression in cutaneous melanocytic tumours. Int J Oncol; 2006 Feb;28(2):345-52
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  • [Title] Macrophage migration inhibitory factor protein and mRNA expression in cutaneous melanocytic tumours.
  • Although MIF's functions in cancer have not been completely elucidated, its expression has usually been correlated with tumour progression and aggressiveness, and it is currently discussed as a new promising target for novel therapies.
  • We evaluated MIF protein expression in 126 skin lesions, including benign and atypical nevi, melanoma and melanoma metastases.
  • Benign nevi were subdivided into nevocytic and Spitz/blue types; and melanomas into the radial, and vertical growth phase.
  • All samples expressed MIF mRNA but it was significantly lower in benign nevi vs atypical nevi, melanomas and metastases (p=0.001; p<0.0001; p=0.002, respectively).
  • Whereas we observed a trend towards higher expression levels of mRNA in atypical and malignant tumours, MIF protein was highly expressed in all lesions, although limited to the cytoplasm in most benign nevi.
  • These observations suggest differences in MIF protein storage, subcellular location and properties in most benign nevi vs atypical and malignant tumours that should be confirmed by further investigation and correlation with clinical outcome.
  • [MeSH-major] Macrophage Migration-Inhibitory Factors / metabolism. Melanoma / metabolism. Nevus, Pigmented / metabolism. RNA, Messenger / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Cell Nucleus / metabolism. Cytoplasm / metabolism. Humans. Immunohistochemistry. Neoplasm Metastasis. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16391788.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Macrophage Migration-Inhibitory Factors; 0 / RNA, Messenger
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84. Fung JM, Smith R, Brown MA, Lau SH, Xie D, Lau GK, Guan XY: Identification and characterization of a novel melanoma tumor suppressor gene on human chromosome 6q21. Clin Cancer Res; 2009 Feb 1;15(3):797-803
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  • [Title] Identification and characterization of a novel melanoma tumor suppressor gene on human chromosome 6q21.
  • PURPOSE: By characterizing a complex chromosome rearrangement involving 6q and 17p in melanoma cell line UACC-930, we isolated a candidate tumor suppressor gene at 6q21, named prenyl diphosphate synthase subunit 2 (PDSS2), which was interrupted by an inversion breakpoint.
  • The purpose of this study was to determine the tumor-suppressive potential of PDSS2 in the development of melanoma.
  • To characterize the tumor-suppressive potential of PDSS2, PDSS2 was stably transfected into a highly tumorigenic melanoma cell line, UACC-903.
  • The tumor-suppressive function of PDSS2 was shown by both in vitro and in vivo assays.
  • The differential expression of PDSS2 in benign nevi and primary melanoma samples was also studied.
  • RESULTS: Down-regulation of PDSS2 was observed in 59 of 87 (67.8%) primary melanomas, which was significantly higher than that in benign nevi (7 of 66, 10.6%; P < 0.001).
  • In addition, an overexpression of the PDSS2 in UACC-903 cells could inhibit tumor cell growth, decrease the colony-forming ability in soft agar, and totally abrogate the tumorigenicity of UACC-903 in nude mice.
  • CONCLUSIONS: Our results support the proposal that PDSS2 is a novel tumor suppressor gene that plays an important role in the development of malignant melanoma.
  • [MeSH-major] Alkyl and Aryl Transferases / genetics. Chromosomes, Human, Pair 6. Genes, Tumor Suppressor. Melanoma / genetics. Skin Neoplasms / genetics
  • [MeSH-minor] Animals. Base Sequence. Cell Line, Tumor. Chromosome Breakage. Down-Regulation. Humans. Mice. Mice, Nude. Molecular Sequence Data. Neoplasm Transplantation

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  • (PMID = 19188149.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.5.- / Alkyl and Aryl Transferases; EC 2.5.1.- / prenyl diphosphate synthase, subunit 2, human
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85. Song JY, Kwon JA, Park CJ: A case of Spitz nevus with multiple satellite lesions. J Am Acad Dermatol; 2005 Feb;52(2 Suppl 1):48-50
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  • Spitz nevus is a benign melnocytic lesion with many histologic similarities to malignant melanoma.
  • [MeSH-major] Nevus, Epithelioid and Spindle Cell / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Dermis / pathology. Female. Humans. Neoplasm Invasiveness

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  • (PMID = 15692514.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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86. Behroozan DS, Goldberg LH, Glaich AS, Kaplan B, Kaye VN: Mohs micrographic surgery for deeply penetrating, expanding benign cutaneous neoplasms. Dermatol Surg; 2006 Jul;32(7):958-65
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  • [Title] Mohs micrographic surgery for deeply penetrating, expanding benign cutaneous neoplasms.
  • [MeSH-major] Mohs Surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Adult. Carcinoma / pathology. Carcinoma / surgery. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Epidermal Cyst / pathology. Epidermal Cyst / surgery. Female. Forehead / pathology. Granular Cell Tumor / pathology. Granular Cell Tumor / surgery. Heel / pathology. Humans. Male. Middle Aged. Neoplasm Metastasis. Nose / pathology. Pilomatrixoma / pathology. Pilomatrixoma / surgery. Scalp / pathology

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  • (PMID = 16875482.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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87. Nazarian RM, Prieto VG, Elder DE, Duncan LM: Melanoma biomarker expression in melanocytic tumor progression: a tissue microarray study. J Cutan Pathol; 2010 Apr;37 Suppl 1:41-7
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  • [Title] Melanoma biomarker expression in melanocytic tumor progression: a tissue microarray study.
  • BACKGROUND: The elucidation of protein biomarkers that are differentially expressed in human melanocytic tumors during tumor progression may lead to the identification of therapeutic targets and novel diagnostic tests.
  • The specialized programs of research excellence (SPORE) in skin cancer developed a melanocytic tumor progression tissue microarray (TMA) to evaluate these candidate biomarkers.
  • METHODS: The TMA contains 480 cores of benign nevi, primary cutaneous melanoma and melanoma metastases.
  • HMB-45 was observed in 18% of nevi and most (72 and 75%) primary melanomas and metastases. c-Kit protein increased with progression from nevi to primary tumor (10 and 77% of cases, respectively) and was decreased in metastases (26% of cases).
  • CONCLUSIONS: Through a collaboration of the Skin SPOREs sponsored by the Organ Systems Branch of the National Cancer Institute (NCI), we identified a list of melanoma biomarkers of interest, developed a melanocytic tumor progression TMA and completed a coordinated analysis of these biomarkers.
  • This TMA has served as a powerful validation tool for newly identified and known melanoma biomarkers by revealing trends in expression during tumor progression and by confirming the heterogeneity of biomarker expression in cutaneous melanocytic tumors.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Melanocytes / metabolism. Melanoma / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Antigens, Neoplasm / metabolism. Cell Nucleus / metabolism. Disease Progression. Humans. Immunohistochemistry. Inhibitor of Apoptosis Proteins. MART-1 Antigen. Melanoma-Specific Antigens. Microphthalmia-Associated Transcription Factor / metabolism. Microtubule-Associated Proteins / metabolism. Neoplasm Proteins / metabolism. Protein Array Analysis. Proto-Oncogene Proteins c-bcl-2 / metabolism. Proto-Oncogene Proteins c-kit / metabolism

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  • (PMID = 20482674.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / BIRC5 protein, human; 0 / Biomarkers, Tumor; 0 / Inhibitor of Apoptosis Proteins; 0 / MART-1 Antigen; 0 / MITF protein, human; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Microphthalmia-Associated Transcription Factor; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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88. Krejsgaard T, Kopp K, Ralfkiaer E, Willumsgaard AE, Eriksen KW, Labuda T, Rasmussen S, Mathiesen AM, Geisler C, Lauenborg B, Becker JC, Zhang Q, Wasik MA, Odum N, Woetmann A: A novel xenograft model of cutaneous T-cell lymphoma. Exp Dermatol; 2010 Dec;19(12):1096-102
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  • [Title] A novel xenograft model of cutaneous T-cell lymphoma.
  • Cutaneous T-cell lymphomas (CTCLs) are characterized by accumulation of malignant T cells in the skin.
  • Early disease resembles benign skin disorders but during disease progression cutaneous tumors develop, and eventually the malignant T cells can spread to lymph nodes and internal organs.
  • Here, we describe a novel xenograft model of tumor stage CTCL, where malignant T cells (MyLa2059) are transplanted to NOD/SCID-B2m(-/-) (NOD.Cg-Prkdc(scid) B2m(tm1Unc) /J) mice.
  • Subcutaneous transplantation of the malignant T cells led to rapid tumor formation in 43 of 48 transplantations, whereas transplantation of non-malignant T cells isolated from the same donor did not result in tumor development.
  • Importantly, the tumor growth was significantly suppressed in mice treated with vorinostat when compared to mice treated with vehicle.
  • Furthermore, in most mice the tumors displayed subcutaneous and/or lymphatic dissemination.
  • Histological, immunohistochemical and flow cytometric analyses confirmed that both tumors at the inoculation site, as well as distant subcutaneous and lymphatic tumors, originated from the transplanted malignant T cells.
  • In conclusion, we describe a novel mouse model of tumor stage CTCL for future studies of disease dissemination and preclinical evaluations of new therapeutic strategies.
  • [MeSH-major] Disease Models, Animal. Lymphoma, T-Cell, Cutaneous / pathology. Transplantation, Heterologous / pathology
  • [MeSH-minor] Animals. Antigens, CD / metabolism. Cell Line, Tumor. Cell Proliferation / drug effects. Cell Transplantation / methods. Cell Transplantation / pathology. Humans. Hydroxamic Acids / pharmacology. Hydroxamic Acids / therapeutic use. Immunophenotyping. Mice. Mice, Inbred NOD. Mice, Knockout. Mice, Nude. Mice, SCID. Neoplasm Metastasis / pathology. Receptors, Chemokine / metabolism. Reproducibility of Results. Skin / pathology

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  • [Copyright] © 2010 John Wiley & Sons A/S.
  • (PMID = 20629733.001).
  • [ISSN] 1600-0625
  • [Journal-full-title] Experimental dermatology
  • [ISO-abbreviation] Exp. Dermatol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA89194
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Hydroxamic Acids; 0 / Receptors, Chemokine; 58IFB293JI / vorinostat
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89. Koljonen V, Jahkola T, Tukiainen E, Granroth G, Haglund C, Böhling T: Tenascin-C in primary Merkel cell carcinoma. J Clin Pathol; 2005 Mar;58(3):297-300
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  • BACKGROUND/AIMS: Merkel cell carcinoma (MCC) is a rare malignant cutaneous neuroendocrine tumour that mostly affects the elderly.
  • It shows rapid progression of the primary tumour, together with a vertical growth pattern into the underlying subcutaneous tissue.
  • Tenascin-C (Tn-C) is a large extracellular matrix glycoprotein that is expressed in various benign and malignant processes.
  • The expression of Tn-C correlated significantly with large tumour size.
  • CONCLUSIONS: Tn-C expression seems to increase with tumour size and malignant behaviour.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Merkel Cell / metabolism. Neoplasm Proteins / metabolism. Skin Neoplasms / metabolism. Tenascin / metabolism
  • [MeSH-minor] Aged. Aged, 80 and over. Cell Division. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Neoplasm Invasiveness. Prognosis

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  • [Cites] Hum Pathol. 2000 Jan;31(1):58-62 [10665914.001]
  • [Cites] Nat Med. 1999 Jun;5(6):662-8 [10371505.001]
  • [Cites] Int J Cancer. 2002 Mar 20;98(3):362-9 [11920587.001]
  • [Cites] Forensic Sci Int. 2002 Apr 18;126(2):118-22 [12084487.001]
  • [Cites] Neurosurgery. 2002 Jul;51(1):183-92; discussion 192-3 [12182416.001]
  • [Cites] Oncology. 2003;64(3):245-50 [12697965.001]
  • [Cites] Anticancer Res. 2003 May-Jun;23(3C):3051-6 [12926160.001]
  • [Cites] Eur J Surg Oncol. 2003 Sep;29(7):607-10 [12943628.001]
  • [Cites] Int J Cancer. 2004 Jan 1;108(1):31-40 [14618612.001]
  • [Cites] APMIS. 2004 Jan;112(1):39-44 [14961973.001]
  • [Cites] Anticancer Res. 2003 Nov-Dec;23(6C):4587-91 [14981900.001]
  • [Cites] Cancer Res. 1983 Jun;43(6):2796-805 [6342760.001]
  • [Cites] Sci Am. 1986 Jun;254(6):42-51 [3010451.001]
  • [Cites] Dev Biol. 1988 Aug;128(2):245-55 [2456233.001]
  • [Cites] Annu Rev Cell Biol. 1989;5:71-92 [2480799.001]
  • [Cites] J Am Acad Dermatol. 1990 Aug;23(2 Pt 1):254-6 [2170468.001]
  • [Cites] Br J Dermatol. 1991 Jan;124(1):13-20 [1704250.001]
  • [Cites] Int J Cancer. 1991 Apr 1;47(6):811-6 [1707033.001]
  • [Cites] Am J Pathol. 1991 Nov;139(5):1143-50 [1719820.001]
  • [Cites] Invasion Metastasis. 1991;11(6):325-31 [1726610.001]
  • [Cites] Development. 1993 Apr;117(4):1183-98 [8404525.001]
  • [Cites] Perspect Dev Neurobiol. 1994;2(1):111-16 [7530137.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1995 Jan 15;31(2):315-23 [7836085.001]
  • [Cites] Methods Enzymol. 1994;245:52-61 [7539094.001]
  • [Cites] Int Arch Allergy Immunol. 1995 Aug;107(4):484-90 [7620364.001]
  • [Cites] Int J Cancer. 1996 Dec 20;69(6):445-7 [8980244.001]
  • [Cites] Matrix Biol. 1998 Aug;17(4):305-16 [9749946.001]
  • [Cites] Clin Cancer Res. 1995 Sep;1(9):1035-41 [9816077.001]
  • [Cites] Br J Cancer. 1998 Dec;78(11):1507-13 [9836485.001]
  • [Cites] Eur J Cancer. 1998 Oct;34(11):1687-92 [9893653.001]
  • [Cites] Am J Dermatopathol. 1999 Feb;21(1):16-20 [10027519.001]
  • [Cites] Gynecol Oncol. 1999 Jun;73(3):415-21 [10366470.001]
  • [Cites] Surg Neurol. 2000 Sep;54(3):235-40 [11118570.001]
  • (PMID = 15735164.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Tenascin
  • [Other-IDs] NLM/ PMC1770604
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90. Xiao H, Gong S, Nie X, Guo C, Zhong G: [Ossifying fibroma of the temporal bone]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2006 Oct;20(19):868-70
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  • OBJECTIVE: To describe the clinical presentation of ossifying fibroma of the temporal bone, and to discuss its diagnosis and treatment.
  • Frozen section evaluation during operation was not definitive but suggested benign nature in histology.
  • The tumor was fully resected.
  • The EAC was sealed by sutured skin, and the extended mastoid cavity was obliterated with abdominal fat.
  • RESULT: The final pathological report indicated the stromal cells were negative for S-100 protein and epithelia membrane antigen (EMA), supporting the diagnosis of ossifying fibroma.
  • One-year follow-up showed the sealed EAC was satisfactory with complete interior and no tumor recurred.
  • CONCLUSION: Ossifying fibroma of the temporal bone is a rare entity, which is a benign neoplasm but may show an aggressive behavior by compression and encroachment upon adjacent structures.
  • [MeSH-major] Bone Neoplasms. Fibroma, Ossifying. Temporal Bone / pathology

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  • (PMID = 17168109.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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91. Rizzo AG, Sanò M, Querci A, Lemma G, Lemma F: [Treatment of skin neoplasms with polidocanol infiltrations. Our experience]. Suppl Tumori; 2005 May-Jun;4(3):S197-8
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  • [Title] [Treatment of skin neoplasms with polidocanol infiltrations. Our experience].
  • They report their 5 years experience in treatment of face and neck skin neoplasms by injections of a sclerosant product as hydropolyethoxydodecan, in case of a difficult good esthetic result with surgery or other therapies because of patients general conditions, such as diabetic ones, or because of their viral nature.
  • Then they affirm to have treated 350 benign and malign tumors with this method.
  • All subjects presented a complete resolution of disease in few weeks and none between them controlled has actually complications or recruitment of neoplasm.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Polyethylene Glycols / administration & dosage. Skin Neoplasms / drug therapy

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  • (PMID = 16437984.001).
  • [ISSN] 2283-5423
  • [Journal-full-title] I supplementi di Tumori : official journal of Società italiana di cancerologia ... [et al.]
  • [ISO-abbreviation] Suppl Tumori
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0AWH8BFG9A / polidocanol; 30IQX730WE / Polyethylene Glycols
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92. Gerber PA, Schulte KW, Ruzicka T, Bruch-Gerharz D: Eccrine porocarcinoma of the head: an important differential diagnosis in the elderly patient. Dermatology; 2008;216(3):229-33
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  • [Title] Eccrine porocarcinoma of the head: an important differential diagnosis in the elderly patient.
  • BACKGROUND: Eccrine porocarcinoma is a rare malignant tumor of the sweat gland, characterized by a broad spectrum of clinicopathologic presentations.
  • Surprisingly, unlike its benign counterpart eccrine poroma, eccrine porocarcinoma is seldom found in areas with a high density of eccrine sweat glands, like the palms or soles.
  • Instead, eccrine porocarcinoma frequently occurs on the lower extremities, trunk and abdomen, but also on the head, resembling various other skin tumors, as illustrated in the patients described herein.
  • All patients were initially diagnosed as having epidermal or melanocytic skin tumors.
  • Only after histopathologic examination were they classified as eccrine porocarcinoma, showing features of epithelial tumors with abortive ductal differentiation.
  • Porocarcinomas are commonly overlooked, or misinterpreted as squamous or basal cell carcinomas as well as other common malignant and even benign skin tumors.
  • Knowledge of the clinical pattern and histologic findings, therefore, is crucial for an early therapeutic intervention, which can reduce the risk of tumor recurrence and serious complications.
  • [MeSH-major] Carcinoma, Skin Appendage / diagnosis. Eccrine Glands / pathology. Head and Neck Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis. Skin Neoplasms / diagnosis

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  • (PMID = 18182815.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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93. Tanahashi J, Kashima K, Daa T, Kondo Y, Kuratomi E, Yokoyama S: A case of cutaneous myoepithelial carcinoma. J Cutan Pathol; 2007 Aug;34(8):648-53
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  • [Title] A case of cutaneous myoepithelial carcinoma.
  • BACKGROUND: Cutaneous myoepithelioma, both benign and malignant, is a rare neoplasm composed of neoplastic myoepithelial cells showing diverse histopathological features, and criteria for discriminating benign or malignant have not been fully clarified.
  • PATIENT: We present a case of cutaneous myoepithelial carcinoma in a 62-year-old woman presenting a solid mass in the right back.
  • RESULTS: Resected tumor was located in the whole dermis and subcutis.
  • Tumor cells were all epithelioid, although plasmacytoid and glycogen-rich clear cells were also observed within the large nodules of the deep part.
  • CONCLUSION: The final diagnosis was cutaneous myoepithelial carcinoma.
  • At present, it seems to be difficult to predict the behavior of myoepithelioma of the skin and soft tissue, although atypia and high mitotic rate are reported to be associated with local recurrence and metastasis.
  • [MeSH-major] Myoepithelioma / pathology. Skin Neoplasms / pathology

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  • (PMID = 17640237.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers
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94. Kumar R, Alavi A: Clinical applications of fluorodeoxyglucose--positron emission tomography in the management of malignant melanoma. Curr Opin Oncol; 2005 Mar;17(2):154-9
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  • The prognosis is linked directly to the initial stage at the time of diagnosis.
  • Early diagnosis and accurate disease staging is important for appropriate treatment planning.
  • It is more sensitive than computed tomography (CT) for detection of metastatic lesions in skin, lymph nodes, and abdomen.
  • False-positive FDG-PET results are due to postsurgical inflammation, other inflammatory lesions, and some benign tumors.
  • [MeSH-major] Fluorodeoxyglucose F18. Melanoma / radionuclide imaging. Positron-Emission Tomography. Radiopharmaceuticals. Skin Neoplasms / radionuclide imaging
  • [MeSH-minor] Humans. Neoplasm Staging

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  • (PMID = 15725921.001).
  • [ISSN] 1040-8746
  • [Journal-full-title] Current opinion in oncology
  • [ISO-abbreviation] Curr Opin Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 37
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95. Suehiro K, Pritzwald-Stegmann P, Lee KM, Teoh HH, Alison PM: Mediastinal and pulmonary metastases of malignant ossifying fibromyxoid tumor. Ann Thorac Surg; 2006 Jun;81(6):2289-91
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  • [Title] Mediastinal and pulmonary metastases of malignant ossifying fibromyxoid tumor.
  • Ossifying fibromyxoid tumor is usually a benign tumor.
  • However some of these tumors with histologic and clinical evidence of malignancy have also been reported and little information is available regarding surgery for metastatic ossifying fibromyxoid tumor.
  • We present a case involving extensive excision of a huge metastatic ossifying fibromyxoid tumor occupying the upper mediastinum and upper half of the right hemithorax.
  • [MeSH-major] Fibroma, Ossifying / pathology. Lung Neoplasms / secondary. Mediastinal Neoplasms / secondary
  • [MeSH-minor] Adult. Brain Neoplasms / complications. Brain Neoplasms / secondary. Diagnostic Errors. Fatal Outcome. Female. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / surgery. Humans. Lipoma / diagnosis. Neoplasm Invasiveness. Pericardium / pathology. Pericardium / surgery. Phrenic Nerve / pathology. Phrenic Nerve / surgery. Pneumonectomy. Radiotherapy, Adjuvant. Reoperation. Seizures / etiology. Skin Neoplasms / pathology. Skin Neoplasms / surgery. Superior Vena Cava Syndrome / etiology

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  • (PMID = 16731174.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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96. Unglaub F, Loos B, Wolf MB, Dragu A, Amann K, Horch RE: Malignant Natural-Killer cell neoplasm presenting as a mucous cyst on the distal interphalangeal joint of the finger. Arch Orthop Trauma Surg; 2009 Dec;129(12):1613-6
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  • [Title] Malignant Natural-Killer cell neoplasm presenting as a mucous cyst on the distal interphalangeal joint of the finger.
  • The analysis revealed the presence of a Natural-Killer cell neoplasm.
  • This case illustrates and stresses the importance of a pathohistological examination when doubts arise about the initial diagnosis of a benign tumorous lesion.
  • [MeSH-major] Killer Cells, Natural. Lymphoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Cysts / diagnosis. Fingers. Humans. Male

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  • (PMID = 19084980.001).
  • [ISSN] 1434-3916
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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97. Trindade F, Haro R, Requena L: Giant angiolymphoid hyperplasia with eosinophilia on the chest. J Cutan Pathol; 2009 Apr;36(4):493-6
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  • This rare benign process occurs with a female predominance.
  • Approximately 85% of the lesions occur in the skin of the head and neck; most of them are around the ear or on the forehead or scalp.
  • Whether angiolymphoid hyperplasia with eosinophilia represents a benign neoplasm or an unusual reaction to varied stimuli, including trauma, the etiology remains unclear.
  • The lesion is benign but may be persistent and is difficult to eradicate.
  • We report on a case of a 58-year-old Caucasian man who presented a purplish pink dome-shaped tumor of size up to 8 cm in diameter located on the chest.

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  • (PMID = 19278439.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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98. De Panfilis G, Ferrari D, Santoro S, Ricci R, Lombardi M, Pedrazzi G, Pepe C, Cortelazzi C, Santini M: Cytoplasmic beta-catenin is lacking in a subset of melanoma-associated naevi, but is detectable in naevus-associated melanomas: potential implications for melanoma tumorigenesis? Br J Dermatol; 2009 Mar;160(3):600-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: To investigate the role played in vivo by beta-catenin in melanoma tumorigenesis, we compared the cytoplasmic detection of beta-catenin in benign melanocytic cells vs. malignant melanoma cells presumably generated from these benign melanocytic cells.
  • METHODS: Fifty-seven consecutive cases of primary cutaneous melanoma were considered, and 15 of them were found to be associated with a melanocytic naevus portion.
  • RESULTS: Virtually all primary cutaneous melanomas, including those associated with a naevus portion, showed cytoplasmic beta-catenin positivity.
  • CONCLUSIONS: Beta-catenin excess may play a role in melanoma tumorigenesis, because beta-catenin cytoplasmic reactivity was found in primary cutaneous melanoma but not in its associated intradermal naevus precursor.
  • As, however, beta-catenin cytoplasmic reactivity was detected not only in primary cutaneous melanoma but also in its associated dysplastic/congenital naevus precursors, beta-catenin stabilization alone is not sufficient to play a decisive role for melanoma onset.
  • [MeSH-major] Cell Transformation, Neoplastic / metabolism. Melanoma / metabolism. Nevus, Pigmented / metabolism. Skin Neoplasms / metabolism. beta Catenin / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cytoplasm / metabolism. Disease Progression. Female. Humans. Male. Middle Aged. Neoplasm Proteins / metabolism. Neoplasm Staging. Young Adult

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  • (PMID = 19183173.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / beta Catenin
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99. Florell SR, Bowen AR, Hanks AN, Murphy KJ, Grossman D: Proliferation, apoptosis, and survivin expression in a spectrum of melanocytic nevi. J Cutan Pathol; 2005 Jan;32(1):45-9
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  • BACKGROUND: Apoptosis is important for maintenance of tissue homeostasis and often dysregulated in cutaneous neoplasms.
  • The apoptosis inhibitor survivin is expressed in melanoma and non-melanoma skin cancers and benign keratinocytic lesions.
  • OBJECTIVE: We determined the expression pattern of survivin in benign melanocytic nevi in comparison to markers of proliferation and apoptosis.
  • CONCLUSIONS: Survivin is consistently expressed in benign melanocytic lesions, while apoptotic cells are rarely identified, suggesting the dysregulation of apoptotic pathways with the accumulation of cells in these neoplasms.

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  • [Cites] Clin Exp Dermatol. 1979 Mar;4(1):49-58 [445877.001]
  • [Cites] Am J Dermatopathol. 1993 Aug;15(4):311-4 [8105711.001]
  • [Cites] Am J Dermatopathol. 1993 Oct;15(5):441-5 [7902020.001]
  • [Cites] J Cutan Pathol. 1994 Oct;21(5):393-7 [7868749.001]
  • [Cites] Am J Dermatopathol. 1995 Feb;17(1):7-11 [7695015.001]
  • [Cites] J Am Acad Dermatol. 1995 Jun;32(6):964-7 [7751466.001]
  • [Cites] Arch Dermatol. 1995 Aug;131(8):915-8 [7632063.001]
  • [Cites] Nature. 1998 Dec 10;396(6711):580-4 [9859993.001]
  • [Cites] J Cutan Pathol. 1999 Feb;26(2):72-7 [10082396.001]
  • [Cites] J Invest Dermatol. 1999 Jul;113(1):111-6 [10417628.001]
  • [Cites] Lab Invest. 1999 Sep;79(9):1121-6 [10496530.001]
  • [Cites] J Clin Oncol. 1999 Sep;17(9):2941-53 [10561374.001]
  • [Cites] Nat Genet. 1999 Dec;23(4):387-8 [10581018.001]
  • [Cites] Nat Cell Biol. 1999 Dec;1(8):461-6 [10587640.001]
  • [Cites] J Invest Dermatol. 1999 Dec;113(6):1076-81 [10594755.001]
  • [Cites] J Invest Dermatol. 2000 Aug;115(2):286-91 [10951248.001]
  • [Cites] Am J Pathol. 2000 Nov;157(5):1415-30 [11073801.001]
  • [Cites] Blood. 2000 Dec 1;96(12):4002-3 [11186274.001]
  • [Cites] Am J Dermatopathol. 2000 Dec;22(6):489-95 [11190439.001]
  • [Cites] Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):635-40 [11149963.001]
  • [Cites] J Invest Dermatol. 2002 Feb;118(2):386-7 [11841561.001]
  • [Cites] J Invest Dermatol. 2003 Jan;120(1):48-55 [12535197.001]
  • [Cites] Clin Cancer Res. 2003 Jul;9(7):2683-92 [12855648.001]
  • [Cites] Am J Pathol. 2003 Nov;163(5):1765-70 [14578177.001]
  • [Cites] Oncogene. 2003 Nov 24;22(53):8568-80 [14634619.001]
  • [Cites] Oncogene. 2003 Nov 24;22(53):8581-9 [14634620.001]
  • [Cites] Oncogene. 2003 Nov 24;22(53):8590-607 [14634621.001]
  • [Cites] Oncogene. 2004 Jan 8;23(1):39-48 [14712209.001]
  • [Cites] Am J Dermatopathol. 2004 Jun;26(3):177-81 [15166502.001]
  • [Cites] Br J Cancer. 1972 Aug;26(4):239-57 [4561027.001]
  • [Cites] Cancer Res. 1976 Apr;36(4):1422-7 [816464.001]
  • (PMID = 15660660.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] ENG
  • [Grant] United States / NIAMS NIH HHS / AR / AR050102-02; United States / NIAMS NIH HHS / AR / K08 AR048618; United States / NCRR NIH HHS / RR / K23RR17525; United States / NCRR NIH HHS / RR / K23 RR017525; United States / NIAMS NIH HHS / AR / R01 AR050102; United States / NIAMS NIH HHS / AR / R01 AR050102-02; United States / NIAMS NIH HHS / AR / KO8AR48618
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Biomarkers, Tumor; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; 0 / RNA, Messenger
  • [Other-IDs] NLM/ NIHMS44268; NLM/ PMC2292117
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100. Tellechea O, Reis JP: Trichogerminoma. Am J Dermatopathol; 2009 Jul;31(5):480-3
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  • A case of distinctive benign follicular neoplasm previously reported under the designation of trichogerminoma is described.
  • The lesion had the characteristics of hair germ tumors; however, most lobules depicted a distinctive pattern of rounded nests of concentrically arranged clear cells.
  • This neoplasm and the other tumors with hair germ differentiation such as trichoblastoma and panfolliculoma seem to represent the same spectrum of hair follicle neoplasms only distinguishable by their degree of differentiation.
  • [MeSH-major] Hair Diseases / pathology. Hair Follicle / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Scalp / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Keratins / metabolism. Male. Middle Aged. Skin Neoplasms / pathology

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  • (PMID = 19542926.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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