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1. Folpe AL, Mentzel T, Lehr HA, Fisher C, Balzer BL, Weiss SW: Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature. Am J Surg Pathol; 2005 Dec;29(12):1558-75
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  • This family of tumors includes angiomyolipoma (AML), clear cell sugar tumor of the lung (CCST), lymphangioleiomyomatosis (LAM), and very rare tumors in other locations.
  • Sites of involvement included the omentum or mesentery (6 cases), uterus (4 cases), pelvic soft tissues (3 cases), abdominal wall (2 cases), uterine cervix (2 cases), and vagina, retroperitoneum, thigh, falciform ligament, scalp, broad ligament, forearm, shoulder, and neck (1 case each).
  • Recurrence and/or metastasis was strongly associated tumor size > median size (8 cm), mitotic activity greater than 1/50 HPF, and necrosis.
  • We conclude that PEComas of soft tissue and gynecologic origin may be classified as "benign," "of uncertain malignant potential," or "malignant."
  • Small PEComas without any worrisome histologic features are most likely benign.
  • [MeSH-major] Biomarkers, Tumor / analysis. Epithelioid Cells / pathology. Genital Neoplasms, Female / pathology. Neoplasms, Connective and Soft Tissue / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Follow-Up Studies. Humans. Immunohistochemistry. Immunophenotyping. Male. Middle Aged. Mitosis. Neoplasm Metastasis. Neoplasm Recurrence, Local. Retrospective Studies. Survival Analysis. Time Factors. Treatment Outcome. Tumor Burden

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  • (PMID = 16327428.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 56
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2. Zyrek-Betts J, Micale M, Lineen A, Chaudhuri PK, Keil S, Xue J, Thomas JE: Malignant blue nevus with lymph node metastases. J Cutan Pathol; 2008 Jul;35(7):651-7
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  • METHODS: We present a patient with metastatic malignant blue nevus and studies on the histopathologic, immunohistochemical, and molecular features of the neoplasm.
  • Molecular loss of heterozygosity analysis showed different allelic patterns at the hOGG-1 locus between the melanoma and control skin specimens with a varying heterozygous allelic pattern in both the benign and malignant blue nevus.
  • Further study is needed to determine if hOGG-1 mutation or c-kit upregulation play a role in the pathogenesis of dendritic melanocytic lesions (either benign or malignant).
  • [MeSH-major] DNA Glycosylases / genetics. Ki-67 Antigen / metabolism. Loss of Heterozygosity. Nevus, Blue. Proto-Oncogene Proteins c-kit / metabolism. Skin Neoplasms
  • [MeSH-minor] Aged. Humans. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Melanoma / genetics. Polymerase Chain Reaction. Scalp / pathology. Skin / pathology. Up-Regulation

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  • (PMID = 17976211.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Ki-67 Antigen; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / oxoguanine glycosylase 1, human
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3. Seyhan T, Borman H, Bal N: Malignant eccrine spiradenoma of the scalp. J Craniofac Surg; 2008 Nov;19(6):1608-12
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  • [Title] Malignant eccrine spiradenoma of the scalp.
  • Malignant eccrine spiradenoma is a rare neoplasm generally arising from long-standing benign eccrine spiradenomas; it is rarely seen on the scalp.
  • A 27-year-old woman with a malignant eccrine spiradenoma of the scalp, which had occurred 8 months after the inadequate excision of a benign eccrine spiradenoma, was treated at our hospital.
  • The tumor with its large subcutaneous extension and the outer table of the cranium were removed.
  • A split-thickness skin graft was applied on the exposed inner table.
  • At 24 months' follow-up, there has been no tumor recurrence.
  • We report a case of a malignant eccrine spiradenoma of the scalp with cranial involvement that arose from an inadequately removed, long-standing, benign eccrine spiradenoma in a young patient.
  • Also, we review the existing literature on malignant eccrine spiradenoma of the scalp.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Head and Neck Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis. Scalp / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Alopecia / diagnosis. Female. Follow-Up Studies. Humans. Neoplasm Invasiveness. Sentinel Lymph Node Biopsy. Skin Transplantation


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4. Schmaltz R, Müller CS, Vogt T: [Sudden growth of previously indolent scalp nodule]. Hautarzt; 2010 Jun;61(6):518-21
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  • [Title] [Sudden growth of previously indolent scalp nodule].
  • Cylindromas are benign adnexal tumors with eccrine and apocrine differentiation.
  • We present a case of scalp cylindromatosis in which a primary cutaneous adenoid-cystic carcinoma developed.
  • As our case shows, histological evaluation is mandatory, even when the clinical diagnosis seems obvious.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Cell Transformation, Neoplastic / pathology. Neoplasm Recurrence, Local / diagnosis. Neoplasms, Multiple Primary / diagnosis. Scalp. Skin Neoplasms / diagnosis

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  • [Cites] Br J Dermatol. 2001 Oct;145(4):653-6 [11703297.001]
  • [Cites] Dermatol Surg. 2003 Jun;29(6):647-9 [12786711.001]
  • [Cites] J Am Acad Dermatol. 2008 Apr;58(4):636-41 [18342709.001]
  • [Cites] Cancer. 1993 Sep 1;72(5):1618-23 [7688655.001]
  • (PMID = 20490442.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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5. Garcia-Bonafe MM, Campins MM, Redecilla PH: Malignant nodular hidradenoma on the scalp: report of a case with fine needle aspiration cytology features and histologic correlation. Acta Cytol; 2009 Sep-Oct;53(5):576-80
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  • [Title] Malignant nodular hidradenoma on the scalp: report of a case with fine needle aspiration cytology features and histologic correlation.
  • BACKGROUND: Malignant nodular hidradenoma (MNH) is a malignant adnexal tumor of the eccrine sweat glands.
  • The histology is similar to that of benign nodular hidradenoma, but MNH shows an infiltrative and invasive pattern, necrosis and angiolymphatic invasion.
  • CASE: A 60-year-old woman, diagnosed with rectal adenocarcinoma 6 months before, underwent fine needle aspiration (FNA) of a nodule on the scalp.
  • CONCLUSION: Rapid, accurate diagnosis of these tumors is important, particularly when they develop at sites where a metastatic process must be ruled out.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Biopsy, Fine-Needle. Head and Neck Neoplasms / pathology. Scalp / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Anaplasia. Cell Differentiation. Female. Giant Cells / pathology. Humans. Immunohistochemistry. Middle Aged. Necrosis. Neoplasm Invasiveness. Predictive Value of Tests

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  • (PMID = 19798887.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Richmond HM, Duvic M, Macfarlane DF: Primary and metastatic malignant tumors of the scalp: an update. Am J Clin Dermatol; 2010;11(4):233-46
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  • [Title] Primary and metastatic malignant tumors of the scalp: an update.
  • In recent years there have been a number of interesting advances in several topics relating to the diagnosis and treatment of cutaneous lesions with particular applicability to primary and metastatic malignancies of the scalp.
  • In this article we provide a general update of advances in this field, and cover the more salient points relating to a variety of malignant tumors that have been reported to appear on the scalp as primary or metastatic lesions.
  • A search and review of the literature on PubMed was made to identify and discuss relevant points relating to diagnosis and treatment of primary and metastatic tumors of the scalp.
  • We describe the anatomy of the scalp, epidemiology of scalp tumors, theories of field cancerization and field therapy, photodynamic therapy, excisional surgical techniques and reconstruction, lymphoscintigraphy, chemoprevention, as well as details relating to atypical fibroxanthoma, Brooke-Spiegler syndrome, nevus sebaceus, cutaneous lymphoma, and metastatic disease.
  • There is a very broad differential diagnosis for scalp nodules, which includes many different benign and malignant diseases, and treatment should be tailored accordingly.
  • [MeSH-major] Scalp / pathology. Skin Neoplasms / therapy
  • [MeSH-minor] Chemoprevention / methods. Diagnosis, Differential. Humans. Lymphoma, B-Cell / pathology. Lymphoma, B-Cell / therapy. Lymphoma, T-Cell, Cutaneous / pathology. Lymphoma, T-Cell, Cutaneous / therapy. Neoplasm Metastasis. Photochemotherapy / methods

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  • (PMID = 20509718.001).
  • [ISSN] 1175-0561
  • [Journal-full-title] American journal of clinical dermatology
  • [ISO-abbreviation] Am J Clin Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] New Zealand
  • [Number-of-references] 68
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7. Battistella M, Peltre B, Cribier B: Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis. J Cutan Pathol; 2010 Oct;37(10):1057-63
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  • [Title] Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis.
  • BACKGROUND: Trichoblastomas (TBs) are benign follicular tumors that can present either as solitary nodule or as multiple facial papules.
  • Only one case of sporadic TB in a composite tumor has been reported, arising in an apocrine poroma.
  • We report the association of TB and benign epidermal/follicular neoplasm in six patients.
  • Lesions were localized on the face and scalp in four of six patients.
  • It was often positive in the associated neoplasm.
  • CONCLUSION: TB can be associated with benign epidermal/follicular neoplasm in composite tumors.
  • Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis.
  • [MeSH-major] Keratosis, Seborrheic / complications. Neoplasms, Multiple Primary / pathology. Skin Diseases / complications. Skin Neoplasms / complications

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  • (PMID = 19615018.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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8. Kazakov DV, Kutzner H, Rütten A, Mukensnabl P, Michal M: Carcinoid-like pattern in sebaceous neoplasms: another distinctive, previously unrecognized pattern in extraocular sebaceous carcinoma and sebaceoma. Am J Dermatopathol; 2005 Jun;27(3):195-203
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  • The cases included 6 men and 1 woman, with their ages at the diagnosis ranging from 43 to 87 years (median age, 59).
  • Locations were the scalp (n = 6) and forearm (n = 1).
  • Although the neoplasm appeared benign architecturally, the presence of cytologic atypia qualified 2 tumors as low-grade carcinomas.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Biomarkers, Tumor / analysis. Carcinoid Tumor / pathology. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / pathology. Diagnosis, Differential. Female. History, 16th Century. Humans. Immunohistochemistry. Inclusion Bodies / pathology. Male. Microscopy, Electron, Transmission. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / ultrastructure. Neoplasms, Adnexal and Skin Appendage / pathology

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  • (PMID = 15900121.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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9. Mosquera JM, Fletcher CD: Expanding the spectrum of malignant progression in solitary fibrous tumors: a study of 8 cases with a discrete anaplastic component--is this dedifferentiated SFT? Am J Surg Pathol; 2009 Sep;33(9):1314-21
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  • Dedifferentiation is a well recognized, if sometimes controversial, form of tumor progression in certain types of soft tissue and bone sarcoma, and confers a worse prognosis when compared with the low-grade counterpart.
  • To date, dedifferentiation has not been described in solitary fibrous tumor (SFT).
  • Two cases were intrathoracic, 2 were located in the deep soft tissue of thigh, and single cases were located in the omentum, scalp, retroperitoneum, and abdominal wall.
  • In addition to typical features of benign-appearing SFT there was an abrupt transition to nondistinctive high-grade sarcoma in all cases.
  • One patient with an 11.5 cm intrathoracic tumor is alive with disease at 58 months after recurrence and metastasis.
  • Our results demonstrate that dedifferentiation in SFT, comparable with that in other low grade/intermediate soft-tissue tumors, poses a higher risk of tumor recurrence and/or metastasis, most notably in large and deep-seated tumors.
  • [MeSH-minor] Adult. Aged. Anaplasia / genetics. Anaplasia / pathology. Antigens, CD34 / metabolism. Biomarkers, Tumor / metabolism. Chromosome Aberrations. Comparative Genomic Hybridization. DNA, Neoplasm / analysis. Female. Humans. Male. Middle Aged. Neoplasm Proteins / metabolism. Sarcoma / genetics. Sarcoma / metabolism. Sarcoma / secondary. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 19718788.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Neoplasm Proteins; 0 / P16 protein, human; 0 / Tumor Suppressor Protein p53
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10. Kang TW, Kang H, Kim HO, Song KY, Park YM: Trichoblastoma in a child. Pediatr Dermatol; 2009 Jul-Aug;26(4):476-7
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  • A trichoblastoma is a benign adnexal neoplasm composed of follicular germinative cells.
  • It most commonly presents as a solitary nodule on the scalp, face, or perineum and occurs equally in males and females.
  • [MeSH-major] Facial Neoplasms / pathology. Neoplasms, Adnexal and Skin Appendage / pathology
  • [MeSH-minor] Cheek. Child. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Treatment Outcome

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  • (PMID = 19689532.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Gil T, Sabo E, Kerner H, Metanes I, Har-Shai Y: Atypical fibroxanthoma of the scalp following hair transplantation in a 35-year-old male. J Plast Reconstr Aesthet Surg; 2010 Oct;63(10):e725-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical fibroxanthoma of the scalp following hair transplantation in a 35-year-old male.
  • Atypical fibroxanthoma (AFX) is an uncommon spindle cell neoplasm of the elderly.
  • This case report presents an atypical case of AFX of the scalp 8 years after hair transplantation in a 35-year-old male patient.
  • Possible synergistic effects of previous sun exposure radiation to the scalp, together with the thermal and radiation injury of carbon dioxide (CO(2)) laser, might explain the mechanisms of the development of AFX at such an early age.
  • To the best of our knowledge, this case report is the first description in the medical literature of development of skin malignancy on a hair-transplanted scalp.
  • [MeSH-major] Alopecia / surgery. Hair / transplantation. Histiocytoma, Benign Fibrous / surgery. Lasers, Gas / adverse effects. Scalp Dermatoses / surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Adult. Humans. Male. Skin Transplantation / methods

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  • [Copyright] Copyright 2010 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20673656.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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12. Siddha M, Budrukkar A, Shet T, Deshpande M, Basu A, Patil N, Bhalavat R: Malignant pilar tumor of the scalp: a case report and review of literature. J Cancer Res Ther; 2007 Oct-Dec;3(4):240-3
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  • [Title] Malignant pilar tumor of the scalp: a case report and review of literature.
  • Pilar tumor is a rare neoplasm arising from the external root sheath of the hair follicle and is most commonly observed on the scalp.
  • These tumors are largely benign, often cystic, and are characterized by trichilemmal keratinization.
  • In this report, we present a case of malignant pilar tumor of the scalp with multiple nodal metastases at presentation.
  • [MeSH-major] Hair Diseases / pathology. Pilomatrixoma / secondary. Scalp. Skin Neoplasms / pathology

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  • (PMID = 18270401.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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13. Alix T, Labbé D, Caquant L, Comoz F, Compère JF, Bénateau H: [Management of whole-scalp tumour: the Poncet-Spiegler cylindroma or turban tumour]. Rev Stomatol Chir Maxillofac; 2009 Apr;110(2):109-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Management of whole-scalp tumour: the Poncet-Spiegler cylindroma or turban tumour].
  • [Transliterated title] Le cylindrome de Poncet-Spiegler étendu du cuir chevelu ou tumeur en turban: prise en charge chirurgicale.
  • INTRODUCTION: The Poncet-Spiegler cylindroma (PSC) is a benign annexal cutaneous tumor which preferentially develops on the scalp, neck, or forehead.
  • When the scalp is completely involved, it presents as a "turban tumor".
  • Treatment is surgery and may be difficult when the tumor is extended.
  • We report the management of turban tumor.
  • OBSERVATION: A 25 year-old female patient was first treated by partial scalp nodule exeresis and histology documented a PSC.
  • The treatment was a complete scalp exeresis and secondary reconstruction with a skin graft.
  • In case of turban tumor, total scalp exeresis and secondary reconstruction with a skin graft is recommended.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Head and Neck Neoplasms / surgery. Scalp / surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Adult. Esthetics. Female. Follow-Up Studies. Humans. Neoplasm Recurrence, Local / surgery. Reconstructive Surgical Procedures. Skin Transplantation / methods

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  • (PMID = 19328506.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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14. Haro R, González-Guerra E, Fariña MC, Martín-Moreno L, Requena L: [Trichilemmal horn: a new case and review of the literature]. Actas Dermosifiliogr; 2009 Jan-Feb;100(1):65-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Cuerno tricolémico: presentación de un nuevo caso y revisión de la literatura.
  • Trichilemmal horn, or trichilemmal keratosis, is an uncommon benign neoplasm of follicular lineage with trichilemmal differentiation.
  • The essential characteristics of this tumor are its clinical presentation in the form of a cutaneous horn with trichilemmal keratinization apparent in the histology study (with a hyperplastic epithelium giving rise to dense, orthokeratotic eosinophilic keratin).
  • We present a new case of this type of tumor in an 82-year-old woman who developed a solitary lesion on her scalp after surgical removal of a trichilemmal cyst.
  • On the basis of the pathology report, the tumor was diagnosed as trichilemmal horn.
  • We review the 33 reports of this tumor in the literature to date.
  • [MeSH-major] Epidermal Cyst / complications. Keratosis / diagnosis. Scalp Dermatoses / diagnosis
  • [MeSH-minor] Aged, 80 and over. Female. Humans. Keratins / analysis. Postoperative Complications / diagnosis. Postoperative Complications / pathology

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  • (PMID = 19268114.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 68238-35-7 / Keratins
  • [Number-of-references] 10
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15. Bansal C, Sinkre P, Stewart D, Cockerell CJ: Two cases of cytokeratin positivity in atypical fibroxanthoma. J Clin Pathol; 2007 Jun;60(6):716-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Head and Neck Neoplasms / diagnosis. Histiocytoma, Benign Fibrous / diagnosis. Keratins / metabolism
  • [MeSH-minor] Aged. Facial Neoplasms / diagnosis. Facial Neoplasms / metabolism. False Positive Reactions. Humans. Male. Neoplasm Proteins / metabolism. Scalp. Skin Neoplasms / diagnosis. Skin Neoplasms / metabolism

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  • [Cites] J Cutan Pathol. 1997 Mar;24(3):176-82 [9085154.001]
  • [Cites] Am J Dermatopathol. 2003 Feb;25(1):1-5 [12544091.001]
  • [Cites] Am J Surg Pathol. 1993 Dec;17(12):1199-209 [8238729.001]
  • [Cites] Arch Dermatol. 1985 Jun;121(6):753-5 [3890760.001]
  • [Cites] Cancer. 1973 Jun;31(6):1541-52 [4709969.001]
  • (PMID = 17483246.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 68238-35-7 / Keratins
  • [Other-IDs] NLM/ PMC1955050
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16. Reid-Nicholson M, Iyengar P, Friedlander MA, Lin O: Fine needle aspiration biopsy of primary mucinous carcinoma of the skin: a case report. Acta Cytol; 2006 May-Jun;50(3):317-22
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  • [Title] Fine needle aspiration biopsy of primary mucinous carcinoma of the skin: a case report.
  • BACKGROUND: Primary mucinous carcinoma of the skin is a rare neoplasm of sweat gland origin.
  • CASE: A 78-year-old woman presented with a 3-cm left scalp mass at an outside institution.
  • Following incomplete excision, multiple subcentimeter nodules developed in the skin adjacent to the biopsy site.
  • Clinical examination and extensive radiographic studies did not reveal primary disease elsewhere, thus supporting a diagnosis of primary mucinous carcinoma of the skin.
  • At the time of wide excision of the residual tumor, sentinel lymph node biopsy revealed a single focus of micrometastasis.
  • The patient declined adjuvant therapy and was disease free 6 months after the initial diagnosis.
  • CONCLUSION: Cutaneous mucinous carcinoma is a tumor characterized by bland histocytologic features and abundant extracellular pools of mucin.
  • Numerous benign and malignant mucin-producing primary and secondary mimics exist, and immunohistochemistry offers limited benefits in differentiating them.
  • Cytologic diagnosis of primary mucinous carcinoma of the skin is possible; however, correlation of clinical, radiologic and pathologic features is necessary to arrive at an accurate diagnosis.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Head and Neck Neoplasms / pathology. Scalp. Skin / pathology. Skin Neoplasms / pathology

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  • (PMID = 16780028.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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17. Estrada-Chavez G, Vega-Memije ME, Lacy-Niebla RM, Toussaint-Caire S: Scalp metastases of a renal cell carcinoma. Skinmed; 2006 May-Jun;5(3):148-50
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  • [Title] Scalp metastases of a renal cell carcinoma.
  • An 80-year-old man presented with a localized tumor of the right occipital scalp.
  • The tumor was a 1-cm, bright red-purple, ulcerated, and crusted exophytic nodule on a smooth base (Figure 1).
  • It was extirpated with the clinical diagnosis of pyogenic granuloma vs. renal metastasis to the scalp.
  • The patient's medical history included a transurethral prostatic resection 3 years earlier and, 1 year later, a right nephrectomy for a 2-kg kidney tumor verbally reported as "benign."
  • The histopathologic diagnosis of metastatic renal cell carcinoma was supported by immunohistochemistry with positive epithelial membrane antigen staining (Figure 4).
  • [MeSH-major] Carcinoma, Renal Cell / diagnosis. Head and Neck Neoplasms / diagnosis. Kidney Neoplasms / diagnosis. Scalp / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Humans. Male. Neoplasm Metastasis


18. Simon SL, Moonis G, Judkins AR, Scobie J, Burnett MG, Riina HA, Judy KD: Intracranial capillary hemangioma: case report and review of the literature. Surg Neurol; 2005 Aug;64(2):154-9
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  • BACKGROUND: Capillary hemangiomas are benign vascular lesions that commonly present at birth or in early infancy on the face, scalp, back, or chest.
  • The patient underwent a resection of her tumor, which was diagnosed as a capillary hemangioma by histopathologic examination.
  • The patient required 2 further resections after the lesion exhibited a rapid regrowth from residual tumor in the left transverse sinus.
  • [MeSH-major] Brain Neoplasms / surgery. Hemangioma, Capillary / surgery. Neoplasm Recurrence, Local / surgery. Pregnancy Complications, Neoplastic / surgery


19. Scheinfeld N: Review of scalp alopecia due to a clinically unapparent or minimally apparent neoplasm (SACUMAN). Acta Derm Venereol; 2006;86(5):387-92
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  • [Title] Review of scalp alopecia due to a clinically unapparent or minimally apparent neoplasm (SACUMAN).
  • Neoplastic cells, both malignant and benign, local occurring and metastatic, can cause alopecia of the scalp.
  • However, the infiltration of neoplastic cells is sometimes not florid; a condition known as "scalp alopecia due to a clinically unapparent or minimally apparent neoplasm" (SACUMAN).
  • The most common neoplasm in which an uncomplicated, minimally or unapparent scalp alopecia occurs and no infiltrate of cancer is suspected is metastatic breast carcinoma.
  • Other causes include squamous and basal cell carcinomas, angiosarcoma, gastric carcinoma, placental site tromphoblastic tumor, and mycosis fungoides.
  • In conclusion, neoplasms causing cicatricial alopecia of the scalp are very rare, so generalizations from the limited number of case reports are of uncertain importance.
  • Moreover, it is likely that many cases of neoplasms causing cicatricial alopecia of the scalp are diagnosed as inflammatory alopecia and not neoplasms, thus depriving us of a full accounting and understanding of this entity.
  • Dermatologists must be aware that in rare cases a bland scalp alopecia can represent a new or recurring, local or metastatic neoplasm.
  • [MeSH-major] Alopecia / etiology. Skin Neoplasms / pathology
  • [MeSH-minor] Breast Neoplasms / pathology. Carcinoma, Basal Cell / pathology. Cicatrix / pathology. Hemangiosarcoma / pathology. Humans. Keloid / complications. Keloid / pathology. Lymphoma / pathology. Scalp / pathology

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  • (PMID = 16983449.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Norway
  • [Number-of-references] 56
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20. Yu DK, Joo YH, Cho KH: Trichoblastoma with apocrine and sebaceous differentiation. Am J Dermatopathol; 2005 Feb;27(1):6-8
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  • Trichoblastoma is a rare, benign tumor that differentiates toward the hair germ, the embryonic precursor of a hair follicle.
  • We report a case of a trichoblastoma, which had developed on the scalp as a solitary 1-cm nodule 3 years ago.
  • An immunohistochemical study showed that the neoplasm, or areas in it, stained positive for low molecular cytokeratin, high molecular cytokeratin, EMA, S-100, and GCDFP-15.
  • [MeSH-major] Apocrine Glands / pathology. Hair Diseases / pathology. Hair Follicle / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Sebaceous Glands / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cell Transformation, Neoplastic. Female. Humans. Immunohistochemistry. Middle Aged. Treatment Outcome

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  • (PMID = 15677969.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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21. Wright NA, Thomas CG, Calame A, Cockerell CJ: Granular cell atypical fibroxanthoma: case report and review of the literature. J Cutan Pathol; 2010 Mar;37(3):380-5
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  • We present a case of granular cell atypical fibroxanthoma of the scalp.
  • The neoplasm occurred as a tender nodule on the frontal scalp of an 82-year-old Caucasian man.
  • We discuss the differential diagnosis and review the previously reported cases of this rare variant of atypical fibroxanthoma.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Xanthomatosis / pathology
  • [MeSH-minor] Aged, 80 and over. Biomarkers, Tumor. Disease-Free Survival. Humans. Immunohistochemistry. Male. Scalp / metabolism. Scalp / pathology. Scalp / surgery. Treatment Outcome

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  • (PMID = 19341433.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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22. Cooper JZ, Newman SR, Scott GA, Brown MD: Metastasizing atypical fibroxanthoma (cutaneous malignant histiocytoma): report of five cases. Dermatol Surg; 2005 Feb;31(2):221-5; discussion 225
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  • BACKGROUND: Atypical fibroxanthoma (AFX) is an unusual malignant fibrohistiocytic tumor of sun-damaged skin.
  • When first described, it was felt to be a reactive tumor of low malignant potential.
  • More recently, it has been shown to be a tumor of intermediate malignant potential.
  • LN-2 staining may be a useful marker in identifying more aggressive tumor behavior.
  • [MeSH-major] Histiocytoma, Benign Fibrous / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Face / pathology. Female. Humans. Lymphatic Metastasis. Male. Neoplasm Metastasis. Scalp / pathology. Upper Extremity / pathology

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  • (PMID = 15762219.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Trindade F, Haro R, Requena L: Giant angiolymphoid hyperplasia with eosinophilia on the chest. J Cutan Pathol; 2009 Apr;36(4):493-6
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  • This rare benign process occurs with a female predominance.
  • Approximately 85% of the lesions occur in the skin of the head and neck; most of them are around the ear or on the forehead or scalp.
  • Whether angiolymphoid hyperplasia with eosinophilia represents a benign neoplasm or an unusual reaction to varied stimuli, including trauma, the etiology remains unclear.
  • The lesion is benign but may be persistent and is difficult to eradicate.
  • We report on a case of a 58-year-old Caucasian man who presented a purplish pink dome-shaped tumor of size up to 8 cm in diameter located on the chest.

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  • (PMID = 19278439.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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24. Plaza JA, Torres-Cabala C, Evans H, Diwan HA, Suster S, Prieto VG: Cutaneous metastases of malignant melanoma: a clinicopathologic study of 192 cases with emphasis on the morphologic spectrum. Am J Dermatopathol; 2010 Apr;32(2):129-36
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  • For the most part, the histologic diagnosis of metastatic melanoma poses little diagnostic difficulty; however, some metastases may adopt unusual or unfamiliar appearances mimicking other benign and malignant conditions.
  • Most tumors were located on the proximal legs, scalp, and arms and ranged from 0.8 to 3.0 cm.
  • One hundred ten cases showed the classic morphologic appearance of melanoma (well-circumscribed epithelioid dermal/subcutaneous nodule), 82 cases showed unusual histologic appearances that mimicked other benign and malignant neoplasms.
  • The histologic diagnosis of cutaneous metastatic melanoma can pose difficulties for diagnosis, especially in the face of an unknown primary neoplasm.
  • Immunohistochemical stains plus careful clinical history helped to establish the correct diagnosis.
  • Our series illustrates that the differential diagnosis of cutaneous metastatic melanoma can be broad and difficult.
  • [MeSH-major] Melanoma / secondary. Neoplasms, Unknown Primary. Skin / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, CD / metabolism. Antigens, CD34 / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Antigens, Neoplasm / metabolism. Desmin / metabolism. Diagnosis, Differential. Female. Humans. Ki-67 Antigen / metabolism. Male. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / metabolism

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  • (PMID = 20010406.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Antigens, Neoplasm; 0 / CD68 antigen, human; 0 / Desmin; 0 / Ki-67 Antigen; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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25. Chaichamnan K, Satayasoontorn K, Puttanupaab S, Attainsee A: Malignant proliferating trichilemmal tumors with CD34 expression. J Med Assoc Thai; 2010 Nov;93 Suppl 6:S28-34
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  • Malignant proliferating trichilemmal tumors (MPTT) are rare neoplasm arising from outer root sheath of hair follicle, the diagnosis of which is base essentially on histological features resulting in occasionally misdiagnosis of squamous cell carcinoma.
  • In difficult cases, however evaluation of additional parameters may be needed to differentiate benign proliferating trichilemmal tumor from MPTT or differentiate PTT and MPTT from squamous cell carcinoma.
  • The contrast p53 and Ki-67 expression pattern in MPTT and PTT may be helpful in the diagnosis of MPTT.
  • [MeSH-major] Antigens, CD34 / metabolism. Carcinoma, Squamous Cell / metabolism. Epidermal Cyst / pathology. Hair Follicle / pathology. Scalp / pathology. Skin Neoplasms / pathology. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged. Neoplasm Recurrence, Local. Treatment Outcome

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  • (PMID = 21280514.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Tumor Suppressor Protein p53
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26. Deutsch J, Trick D, Delank KW: [Giant scalp mass]. HNO; 2010 Dec;58(12):1204-7
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  • [Title] [Giant scalp mass].
  • [Transliterated title] Monströser Tumor der Kopfhaut.
  • A 55-year-old man was referred to our department with bleeding from a painless tumor located at the left parietal region of the head which had been progressively growing for a period of 2 years.
  • The partly livid and ulcerated surface of the tumor was interspersed with light-yellow chalky material.
  • Histopathological examination led to the diagnosis of a giant pilomatricoma.
  • Pilomatricoma is a rare, benign skin neoplasm that originates from hair matrix cells and is most frequently located in the head and neck region.
  • [MeSH-major] Hair Diseases / diagnosis. Head and Neck Neoplasms / diagnosis. Pilomatrixoma / diagnosis. Scalp. Skin Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • [Cites] Arch Dermatol. 1961 Apr;83:606-18 [13700704.001]
  • [Cites] J Am Acad Dermatol. 1998 Aug;39(2 Pt 1):191-5 [9704827.001]
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  • (PMID = 20577705.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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27. Kumar PV, Monabati A, Tabei SZ, Ramzy M, Husseini SV, Khajeh F: Metastatic follicular thyroid carcinoma diagnosed by fine needle aspiration cytology: a report of 3 cases. Acta Cytol; 2005 Mar-Apr;49(2):177-80
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  • BACKGROUND: Follicular thyroid carcinomas (FTCs) usually have a benign clinical course, with an excellent long-term prognosis and a propensity for vascular invasion.
  • CASES: A 68-year-old man presented with a thyroid mass and skin nodule on the scalp.
  • Skin nodule aspiration revealed metastatic FTC.
  • CONCLUSION: Cytologic diagnosis of metastatic FTC has been reported rarely.
  • Marginal (fire-flare) vacuoles aid in making the diagnosis of metastatic FTC.
  • [MeSH-minor] Aged. Anemia / etiology. Biopsy, Fine-Needle. Bone and Bones / pathology. Epithelial Cells / pathology. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Prognosis. Skin Neoplasms / secondary

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  • (PMID = 15839624.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Velnar T, Bunc G: Iatrogenic metastasis of a benign meningioma to the periosteum at the site of previous craniotomy: a case report. Wien Klin Wochenschr; 2008;120(23-24):766-9
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  • [Title] Iatrogenic metastasis of a benign meningioma to the periosteum at the site of previous craniotomy: a case report.
  • As far as we know, the presented case is the first report in the literature of iatrogenic seeding of a benign meningioma to the scalp following surgery.
  • Histologically, the ectopic tumor was an atypical meningioma, similar to the one excised 10 years previously, with no relation to the other two intracranial masses.
  • Because of the histological similarity and the location in the old craniotomy, the ectopic tumor was believed to have developed from an implantation metastasis as a consequence of the first surgery.
  • The authors suggest that strict adherence to oncological principles should be applied in the case of benign neoplasms in order to prevent contamination of wounds with tumor cells and potential recurrence.
  • [MeSH-major] Craniotomy. Meningeal Neoplasms / surgery. Meningioma / secondary. Meningioma / surgery. Neoplasm Seeding. Neoplasms, Multiple Primary / surgery. Periosteum. Skull Neoplasms / secondary

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  • [Cites] J Neurosurg. 2002 Sep;97(3):683-6 [12296654.001]
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  • (PMID = 19122989.001).
  • [ISSN] 0043-5325
  • [Journal-full-title] Wiener klinische Wochenschrift
  • [ISO-abbreviation] Wien. Klin. Wochenschr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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29. Mistry R, Wademan B, Avery G, Tan ST: A case of misdiagnosed squamous cell carcinoma due to alternative medical misadventure--time for tightening regulation? N Z Med J; 2010 Apr 9;123(1312):61-7
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  • The alternative medicine practitioner allegedly repeatedly reassured the patient that her condition was benign and advised against seeking conventional medical treatment.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Complementary Therapies / legislation & jurisprudence. Diagnostic Errors. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Anemia, Macrocytic / diagnosis. Delayed Diagnosis. Dura Mater / pathology. Female. Hemoglobins / analysis. Humans. Leukocyte Count. Neoplasm Invasiveness. New Zealand. Radiotherapy, Adjuvant. Scalp / pathology. Scalp / surgery. Skin Ulcer / microbiology. Skin Ulcer / pathology. Skull / pathology


30. Kim YH, Lee YK, Choi KW, Lee CY, Kim KH: A Case of Trichilemmal Carcinoma Treated with Mohs Micrographic Surgery. Ann Dermatol; 2008 Sep;20(3):157-61
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  • Trichilemmal carcinoma is a cutaneous adnexal tumor originating from the outer root sheath of hair follicle, and it was first described by Headington in 1976.
  • Clinically, it usually occurs as an asymptomatic solitary papule, nodule or mass on the face or scalp.
  • This neoplasm is a malignant counterpart of trichilemmoma, and it has been reported in the literature as trichilemmal carcinoma, tricholemmal carcinoma, malignant trichilemmoma, and tricholemmocarcinoma.
  • Although histologically, trichilemmal carcinoma frequently has maliganant features, it has a relatively benign clinical behavior.
  • We think Mohs micrographic surgery is a useful treatment modality in trichilemmal carcinoma because the final skin defect is smaller than a wide excision.

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  • (PMID = 27303183.001).
  • [ISSN] 1013-9087
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC4903970
  • [Keywords] NOTNLM ; Mohs micrographic surgery / Trichilemmal carcinoma
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31. Carter JJ, Kaur MR, Hargitai B, Brown R, Slator R, Abdullah A: Congenital desmoplastic trichoepithelioma. Clin Exp Dermatol; 2007 Sep;32(5):522-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Desmoplastic trichoepithelioma (DT) is a rare benign adnexal neoplasm considered to have follicular differentiation.
  • A girl was born at term to a healthy mother after an uneventful pregnancy and was noted to have widespread erythematous plaques with milia-like lesions over the right scalp, face and neck, with some areas of atrophic scarring.
  • Histology and immunohistochemistry of incisional biopsies of the lesions were consistent with a diagnosis of DT.
  • [MeSH-major] Facial Neoplasms / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Skin / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Follow-Up Studies. Humans. Infant. Infant, Newborn. Rare Diseases / congenital

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  • (PMID = 17459070.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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32. Wygledowska-Kania M, Kamińska-Winciorek G, Krauze E, Brzezińska-Wcisło L, Kajor M: Multifocal type of pilomatrixoma. Adv Med Sci; 2007;52:251-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pilomatrixoma is a benign skin neoplasm that arises from hair follicle matrix cells.
  • The skin lesion occurs usually as a solitary tumor and the multifocal types are very rare.
  • Skin changes can be described as a firm to hard, non-painful, oval-shaped tumor that is covered by normal skin.
  • It commonly occurs on a scalp, face, neck and rarely back and extremities.
  • The first skin lesion appeared on the left arm 6 years ago.
  • Histopathological test has proved the clinical diagnosis of pilomatrixoma.
  • [MeSH-major] Pilomatrixoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Cicatrix / diagnosis. Diagnosis, Differential. Humans. Immunohistochemistry / methods. Inflammation. Male. Treatment Outcome

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  • (PMID = 18217427.001).
  • [ISSN] 1896-1126
  • [Journal-full-title] Advances in medical sciences
  • [ISO-abbreviation] Adv Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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33. Izumi M, Tang X, Chiu CS, Nagai T, Matsubayashi J, Iwaya K, Umemura S, Tsuboi R, Mukai K: Ten cases of sebaceous carcinoma arising in nevus sebaceus. J Dermatol; 2008 Nov;35(11):704-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Sebaceous carcinoma arising in nevus sebaceous predominantly occurred on the scalp (8/10) of elderly women (mean age, 67.7 years).
  • In two cases there were coexisting benign-looking sebaceous lesions at the periphery of the main cancer nodule, and in these lesions p53 showed low positivity compared with the clearly malignant area.
  • There was co-occurrence of another neoplasm in three cases with trichoblastoma, sebaceoma and syringocystadenoma papilliferum, respectively.
  • These clinicopathological features of sebaceous carcinomas developing in the nevus sebaceus seem to indicate different biological entities from de novo sebaceous carcinoma.
  • [MeSH-major] Carcinoma / secondary. Nevus, Sebaceous of Jadassohn / pathology. Sebaceous Gland Neoplasms / secondary. Skin / pathology


34. Rammeh-Rommani S, Fezaa B, Chelbi E, Kammoun MR, Ben Jilani SB, Zermani R: Syringocystadenoma papilliferum: report of 8 cases. Pathologica; 2006 Jun;98(3):178-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Syringocystadenoma papilliferum (SCAP) is a rare cutaneous adnexal neoplasm with variable clinical appearance and characteristic histology.
  • It arises in about one third of cases within a sebaceous hamartoma (SH) and in this case, multiple other benign adnexal neoplasms may be associated with it.
  • The age at the time of the diagnosis varied from 3 to 48 years with an average age of 28 years.
  • Three tumors were localized in the scalp, 2 in the trunk, and 3 others of unusual locations: 1 in the eyelid, 1 in the thigh and 1 in the popliteal fossa.

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  • (PMID = 17036946.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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35. Tellechea O, Reis JP: Trichogerminoma. Am J Dermatopathol; 2009 Jul;31(5):480-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A case of distinctive benign follicular neoplasm previously reported under the designation of trichogerminoma is described.
  • A 45-year-old man presented with an asymptomatic nodule on the scalp since 3 years.
  • This neoplasm and the other tumors with hair germ differentiation such as trichoblastoma and panfolliculoma seem to represent the same spectrum of hair follicle neoplasms only distinguishable by their degree of differentiation.
  • [MeSH-major] Hair Diseases / pathology. Hair Follicle / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Scalp / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Keratins / metabolism. Male. Middle Aged. Skin Neoplasms / pathology

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  • (PMID = 19542926.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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