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1. Liu CC, Wang HW, Li FY, Hsu PK, Huang MH, Hsu WH, Hsu HS, Wang LS: Solitary fibrous tumors of the pleura: clinicopathological characteristics, immunohistochemical profiles, and surgical outcomes with long-term follow-up. Thorac Cardiovasc Surg; 2008 Aug;56(5):291-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary fibrous tumors of the pleura: clinicopathological characteristics, immunohistochemical profiles, and surgical outcomes with long-term follow-up.
  • BACKGROUND: Solitary fibrous tumors of the pleura (SFTP) are rare.
  • (2) to determine whether an immunohistochemical (IHC) study can be helpful in distinguishing benign from malignant SFTPs; and (3) to provide more complete information to better predict prognosis.
  • All cytologic studies of pleural effusion were negative for malignant cells.
  • Complete pleural resection with adequate safe margins was performed for all patients.
  • Eleven cases proved to have benign tumors and 4 had malignancies.
  • Conventional factors, including tumor size, tumor shape, symptomatic presentation, and histological type did not affect prognosis.
  • Interestingly, p16 expression was significantly associated with tumor recurrence ( P = 0.009).
  • CONCLUSION: Complete pleural resection with adequate safe margins can achieve satisfactory outcomes in a majority of cases, but long-term follow-up for all patients is recommended due to the potential for late tumor recurrence.
  • However, IHC studies of the CD-34 and bcl-2 biomarkers can be important for further differential diagnosis, and p16 expression can be used to predict tumor recurrence.
  • [MeSH-major] Biomarkers, Tumor / analysis. Immunohistochemistry. Pulmonary Surgical Procedures. Solitary Fibrous Tumor, Pleural
  • [MeSH-minor] Aged. Diagnosis, Differential. Disease-Free Survival. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local. Retrospective Studies. Time Factors. Treatment Outcome

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  • (PMID = 18615377.001).
  • [ISSN] 0171-6425
  • [Journal-full-title] The Thoracic and cardiovascular surgeon
  • [ISO-abbreviation] Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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2. Krause E, Gürkov R, Klauss V: [Solitary fibrous tumor in the orbit. Case report and review of the literature]. HNO; 2009 Feb;57(2):169-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Solitary fibrous tumor in the orbit. Case report and review of the literature].
  • [Transliterated title] Solitärer fibröser Tumor in der Orbita. Fallbericht und Literaturübersicht.
  • BACKGROUND: Solitary fibrous tumor (SFT) is a mesenchymal neoplasm with a benign growth behavior.
  • It was initially described in the pleura and has since been found in extrathoracic locations.
  • Tumor growth over 7 years led to a severe exophthalmos with loss of vision.
  • CONCLUSION: SFT is a rare differential diagnosis of orbital lesions and can be appropriately treated by surgical resection.

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  • (PMID = 19221826.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 18
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3. Lu C, Ji Y, Shan F, Guo W, Ding J, Ge D: Solitary fibrous tumor of the pleura: an analysis of 13 cases. World J Surg; 2008 Aug;32(8):1663-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary fibrous tumor of the pleura: an analysis of 13 cases.
  • BACKGROUND: Solitary fibrous tumor of the pleura is a rare soft-tissue tumor.
  • In search of appropriate diagnosis and treatment methods, we present our experience with 13 patients.
  • Seven tumors were malignant and the other six were benign.
  • Immunohistochemical staining showed nestin was positive in three malignant solitary fibrous tumors of pleura (3/7), which were negative for CD34.
  • CONCLUSION: Ultrasonography-guided core needle biopsy combined with immunohistochemical analysis might be a safe and rapid method to provide a confirmatory diagnosis before resection.
  • We speculate that CD34-negative and nestin-positive might be a malignant marker for solitary fibrous tumor of pleura.
  • [MeSH-major] Neoplasms, Fibrous Tissue / diagnosis. Neoplasms, Fibrous Tissue / surgery. Pleural Neoplasms / diagnosis. Pleural Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Biopsy, Needle / methods. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Metastasis. Radiography, Thoracic. Thoracic Surgery, Video-Assisted. Tomography, X-Ray Computed. Ultrasonography, Interventional

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  • (PMID = 18427887.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 20
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4. Sung SH, Chang JW, Kim J, Lee KS, Han J, Park SI: Solitary fibrous tumors of the pleura: surgical outcome and clinical course. Ann Thorac Surg; 2005 Jan;79(1):303-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary fibrous tumors of the pleura: surgical outcome and clinical course.
  • BACKGROUND: The aim of this study was to define more precisely the surgical outcome and clinical course of solitary fibrous tumors of the pleura.
  • METHODS: We conducted a retrospective review of the clinical records of patients who had undergone surgical resection for benign and malignant solitary fibrous tumors of the pleura during a 10-year period (1993 to 2003).
  • Thirty-six patients (57.1%) were symptomatic at the time of diagnosis.
  • Forty-four cases (69.8%) were benign and 19 (30.2%) were malignant.
  • Symptomatic presentation and the impression of a nonpleural tumor by imaging study were found to be related to a malignant pathologic diagnosis.
  • The radiologic impression of solitary fibrous tumors of the pleura was also related to mass excision only.
  • [MeSH-major] Neoplasms, Fibrous Tissue / surgery. Pleural Neoplasms / surgery. Thoracic Surgery, Video-Assisted. Thoracotomy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Child. Child, Preschool. Female. Humans. Incidental Findings. Life Tables. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Sternum / surgery. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15620963.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 17
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5. Balduyck B, Lauwers P, Govaert K, Hendriks J, De Maeseneer M, Van Schil P: Solitary fibrous tumor of the pleura with associated hypoglycemia: Doege-Potter syndrome: a case report. J Thorac Oncol; 2006 Jul;1(6):588-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary fibrous tumor of the pleura with associated hypoglycemia: Doege-Potter syndrome: a case report.
  • Tumor-associated hypoglycemia as a paraneoplastic phenomenon is a well-known entity and is referred to as Doege-Potter syndrome.
  • All investigations proved to be normal, except for a chest x-ray, which showed a large pleural mass.
  • On transthoracic puncture, a tumor of pleural origin was diagnosed.
  • This tumor, presenting as a large, well-circumscribed encapsulated mass, was removed by thoracotomy.
  • On pathologic examination, the diagnosis of a solitary fibrous tumor with benign characteristics was made.
  • Solitary fibrous tumors are localized tumors of the pleura with an unpredictable behavior.
  • [MeSH-major] Neoplasms, Fibrous Tissue / pathology. Neoplasms, Fibrous Tissue / surgery. Pleural Neoplasms / pathology. Pleural Neoplasms / surgery. Pneumonectomy / methods
  • [MeSH-minor] Aged. Biopsy, Needle. Bronchoscopy. Follow-Up Studies. Humans. Immunohistochemistry. Male. Neoplasm Staging. Radiography, Thoracic. Thoracotomy / methods. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17409923.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Leoncini G, Maio V, Puccioni M, Franchi A, De Giorgi V, Ucci F, Santucci M, Massi D: Orbital solitary fibrous tumor: a case report and review of the literature. Pathol Oncol Res; 2008 Jun;14(2):213-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Orbital solitary fibrous tumor: a case report and review of the literature.
  • Solitary fibrous tumor (SFT) is a rare spindle cell neoplasm typically arising in the pleura and involving the orbit as its most common extra-pleural location.
  • The tumor had a benign clinical course, with radical surgical excision followed by regression of the clinical symptoms.
  • We review the clinical, histopathological, and immunohistochemical features of the orbital SFT described so far, with particular emphasis on differential diagnosis with other spindle cell orbital neoplasms.
  • [MeSH-major] Orbital Neoplasms / diagnosis. Orbital Neoplasms / surgery. Solitary Fibrous Tumors / diagnosis. Solitary Fibrous Tumors / surgery
  • [MeSH-minor] Diagnosis, Differential. Exophthalmos / etiology. Female. Humans. Immunohistochemistry. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 18493869.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 26
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7. Patel T, Bansal R, Trivedi P, Modi L, Shah MJ: Subcutaneous metastases of sarcomatoid mesothelioma with its differential diagnosis on fine needle aspiration--a case report. Indian J Pathol Microbiol; 2005 Oct;48(4):482-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Subcutaneous metastases of sarcomatoid mesothelioma with its differential diagnosis on fine needle aspiration--a case report.
  • Metastasis of mesothelioma of the pleura, to the skin and subcutis is an extremely rare occurrence.
  • A 25 year old woman, who had undergone chemotherapy, partial excision of tumor followed by radiotherapy of sarcomatoid mesothelioma of the pleura, presented three months later with painless widespread subcutaneous nodules.
  • It is essential to differentiate neoplasm metastatic to the skin and subcutis from primary and benign lesions of the same region.
  • FNAC is accurate and efficient, in conjugation with clinical history, and it also prevents surgical biopsy in the diagnosis of metastatic subcutaneous lesion.
  • [MeSH-major] Mesothelioma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Pleural Neoplasms. Skin Neoplasms / diagnosis. Skin Neoplasms / secondary. Subcutaneous Tissue

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  • (PMID = 16366102.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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9. Robinson LA: Solitary fibrous tumor of the pleura. Cancer Control; 2006 Oct;13(4):264-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary fibrous tumor of the pleura.
  • BACKGROUND: The solitary fibrous tumor of the pleura (SFTP) is a rare primary tumor arising from mesenchymal cells in the areolar tissue subjacent to the mesothelial-lined pleura.
  • The tumor appears to be unrelated to malignant pleural mesothelioma, the most common primary tumor of the pleura.
  • METHODS: In just over half of these cases, the neoplasm presents as an asymptomatic mass, is often quite large, and is benign in 78% to 88% of patients.
  • The initial evaluation and diagnosis, tumor classification, surgical treatment, results of therapy, and long-term prognosis are reviewed, based on a selective review of the literature from MEDLINE beginning 1980.
  • RESULTS: Complete en bloc surgical resection is the preferred treatment of benign and malignant varieties of the tumor.
  • The pedunculated tumors attached to the visceral pleura can be effectively treated with a wedge resection of lung.
  • CONCLUSIONS: Benign SFTP has a high cure rate and an 8% local recurrence rate that is usually amenable to curative re-excision.
  • The majority of patients with recurrent disease die of the tumor within 2 years.
  • [MeSH-major] Neoplasms, Fibrous Tissue / diagnosis. Neoplasms, Fibrous Tissue / therapy. Pleural Neoplasms / diagnosis. Pleural Neoplasms / therapy
  • [MeSH-minor] Diagnosis, Differential. Humans. Incidence. Neoadjuvant Therapy. Thoracic Surgical Procedures. Tomography, X-Ray Computed. United States / epidemiology

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  • (PMID = 17075563.001).
  • [ISSN] 1073-2748
  • [Journal-full-title] Cancer control : journal of the Moffitt Cancer Center
  • [ISO-abbreviation] Cancer Control
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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10. Fatima S, Ahmed Z, Azam M: Benign metastasizing leiomyoma. Indian J Pathol Microbiol; 2010 Oct-Dec;53(4):802-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign metastasizing leiomyoma.
  • Benign metastasizing leiomyoma (BML) is a rare condition, affecting predominantly reproductive-age females with uterine leiomyomata and is most often associated with multiple benign-appearing smooth muscle tumors in lungs.
  • Postoperatively, she developed left-sided pleural effusion.
  • Histopathology of one of the pleura-based nodules revealed a neoplasm composed of interlacing fascicles of spindle cells with uniform nuclei.
  • The tumor cells were positive for alpha-smooth muscle actin and negative for CD34 immunohistochemical stain.
  • [MeSH-major] Leiomyoma / diagnosis. Lung Neoplasms / secondary. Pleural Neoplasms / secondary. Uterine Neoplasms / diagnosis
  • [MeSH-minor] Actins / analysis. Adult. Antigens, CD34 / analysis. Female. Histocytochemistry. Humans. Hysterectomy. Immunohistochemistry. Microscopy. Pleural Effusion / diagnosis. Radiography, Thoracic. Tomography, X-Ray Computed

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  • (PMID = 21045423.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / ACTA2 protein, human; 0 / Actins; 0 / Antigens, CD34
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11. Tanaka M, Sawai H, Okada Y, Yamamoto M, Funahashi H, Hayakawa T, Takeyama H, Manabe T: Malignant solitary fibrous tumor originating from the peritoneum and review of the literature. Med Sci Monit; 2006 Oct;12(10):CS95-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant solitary fibrous tumor originating from the peritoneum and review of the literature.
  • BACKGROUND: Solitary fibrous tumor (SFT) is a rare neoplasm frequently involving the pleura.
  • Benign and malignant forms of the tumor occur, the benign variant being three to four times more common than the malignant.
  • CASE REPORT: We present herein a rare case of large malignant solitary fibrous tumor (SFT) originating from the peritoneum.
  • An abdominal computed tomography scan revealed a well-defined solid tumor with mixed density.
  • An abdominal ultrasonography (US) revealed a well-circumscribed solid tumor containing a partially cystic lesion.
  • Liposarcoma originating from the retroperitoneum was suggested, and the patient underwent a complete resection of the tumor as well as the left kidney because tumor invasion of the upper left kidney was suspected.
  • Immunohistochemically, the spindle-shaped cells were positive for CD34, and the diagnosis was SFT originating from the peritoneum.
  • CONCLUSIONS: This case gave us some difficulty, and the correct diagnosis of the peritoneal mass was valuable.
  • To diagnose the malignant potential of this type of tumor accurately may have value to direct the appropriate therapeutic operations after surgery and postoperative progress observation.
  • [MeSH-major] Neoplasms, Fibrous Tissue / diagnosis. Neoplasms, Fibrous Tissue / pathology. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / pathology

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  • (PMID = 17006407.001).
  • [ISSN] 1234-1010
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antigens, CD34
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12. Szczepulska-Wójcik E, Langfort R, Roszkowski-Sliz K: [A comparative evaluation of immunohistochemical markers for the differential diagnosis between malignant mesothelioma, non-small cell carcinoma involving the pleura, and benign reactive mesothelial cell proliferation]. Pneumonol Alergol Pol; 2007;75(1):57-69
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A comparative evaluation of immunohistochemical markers for the differential diagnosis between malignant mesothelioma, non-small cell carcinoma involving the pleura, and benign reactive mesothelial cell proliferation].
  • INTRODUCTION: Histopathological diagnosis of malignant mesothelioma (MM) and differentiating it from tumors infiltrating the pleura is very difficult.
  • Distinguishing benign reactive mesothelial cell proliferation from MM also presents problems.
  • The objective of this study was to evaluate the significance of selected immunohistochemical stains in differentiating MM from non-small cell lung cancers infiltrating the pleura and from benign reactive mesothelial cell proliferation.
  • MATERIAL AND METHODS: The material encompassed 86 cases of MM, 54 cases of NSCLC infiltrating the pleura, and 43 cases of benign reactive mesothelial cell proliferation.
  • Non-small cell lung cancers infiltrating the pleura: Coexpression of cytokeratin and vimentin was found in 17.6% of the cases, positive staining of membranes for EMA, in 13% cases.
  • Benign reactive mesothelial cell proliferation: Protein p53 was present in 9.3% of cases, whereas no positive staining for EMA was found.
  • In the diagnosis of spindle-cell pleural tumors and the fibrous form of MM and benign reactive mesothelial cell proliferation , markers of mesothelial cells are noncontributory.
  • Immunohistochemical staining fails to identify a reactive process, but a diffuse, positive stain for EMA and the presence of protein p53 support the diagnosis of MM.
  • [MeSH-major] Antigens, Tumor-Associated, Carbohydrate / analysis. Biomarkers, Tumor / analysis. Carcinoma, Non-Small-Cell Lung / pathology. Mesothelioma / pathology. Neoplasm Proteins / analysis. Neoplasms, Mesothelial / pathology. Pleural Neoplasms / pathology
  • [MeSH-minor] Aged. Antibodies, Monoclonal / analysis. Diagnosis, Differential. Epithelium / chemistry. Epithelium / pathology. Female. Humans. Hyperplasia / pathology. Immunohistochemistry. Lung / chemistry. Lung / pathology. Male. Middle Aged. Pleura / chemistry. Pleura / pathology. Pleural Effusion / chemistry. Sensitivity and Specificity

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  • (PMID = 17541913.001).
  • [ISSN] 0867-7077
  • [Journal-full-title] Pneumonologia i alergologia polska
  • [ISO-abbreviation] Pneumonol Alergol Pol
  • [Language] pol
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Tumor-Associated, Carbohydrate; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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13. Perna V, Rivas F, Morera R, Saumench J, Ramos R, Macia I, Ureña A, Escobar I, Villalonga R, Moya J: Localized (solitary) fibrous tumors of the pleura: an analysis of 15 patients. Int J Surg; 2008 Aug;6(4):298-301
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  • [Title] Localized (solitary) fibrous tumors of the pleura: an analysis of 15 patients.
  • BACKGROUND: Localized fibrous tumors of the pleura (LFTPs) are rare neoplasms, which are considered to originate from submesothelial connective tissue.
  • Malignant transformation was seen in 1 patient 26 months after resection of a benign tumor.
  • One of these underwent redo-surgery and required pneumonectomy; in the other one surgery is not indicated because at the time of diagnosis the patient was 85 years.
  • CONCLUSIONS: For histologically benign tumors, because of the risk of recurrence and malignant transformation, complete surgical resection is indicated and long-term follow-up is recommended in all patients.
  • [MeSH-major] Fibroma / mortality. Fibroma / pathology. Pleural Neoplasms / mortality. Pleural Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Needle. Cohort Studies. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Pleura / pathology. Pleura / surgery. Prognosis. Radiography, Thoracic. Retrospective Studies. Risk Assessment. Survival Rate. Thoracotomy / methods. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18579460.001).
  • [ISSN] 1743-9159
  • [Journal-full-title] International journal of surgery (London, England)
  • [ISO-abbreviation] Int J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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14. Hayakawa M: [Pleural lipoma: report of a case]. Kyobu Geka; 2005 Dec;58(13):1185-8
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  • [Title] [Pleural lipoma: report of a case].
  • Although lipomas are the most common form of the benign neoplasm, occurrence within the thoracic cage is uncommon, and lipomas originating from the pleura are very rare.
  • A chest wall tumor was suspected based on the findings of computed tomography (CT) of the thorax.
  • The tumor was resected by video-assisted thoracoscopic surgery and the patient remains well with no recurrence 4 years postoperatively.
  • The resected tumor was a yellowish pleural mass and the pathological diagnosis was a benign lipoma.
  • It is possible to make a diagnosis of lipoma preoperatively by CT and magnetic resonance imaging (MRI), however, the correct differential diagnosis of lipoma and liposarcoma is imperfect only by radiological findings necessitating surgical removal if possible.
  • [MeSH-major] Lipoma / surgery. Pleural Neoplasms / surgery. Thoracic Surgery, Video-Assisted

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  • (PMID = 16359024.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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15. Piastra M, Ruggiero A, Caresta E, Granone P, Chiaretti A, Polidori G, Riccardi R: Critical presentation of pleuropulmonary blastoma. Pediatr Surg Int; 2005 Mar;21(3):223-6
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  • We report two cases of critical presentation of a quite rare lung neoplasm of childhood.
  • Presentation findings were at the extremes of the clinical pattern of this polymorphous neoplasm, ranging from an enormous solid mass causing airway compression and dislocation to an apparently benign cystic lesion discovered because of a tension pneumothorax.
  • [MeSH-major] Lung Neoplasms / diagnosis. Pulmonary Blastoma / diagnosis
  • [MeSH-minor] Biopsy. Child, Preschool. Combined Modality Therapy. Cysts / diagnostic imaging. Cysts / pathology. Cysts / therapy. Diagnosis, Differential. Follow-Up Studies. Humans. Lung / diagnostic imaging. Lung / pathology. Pleura / diagnostic imaging. Pleura / pathology. Radiography, Thoracic. Tomography, X-Ray Computed

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  • [Cites] J Pediatr Hematol Oncol. 2003 Jan;25(1):78-81 [12544779.001]
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  • (PMID = 15756566.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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16. Schmitz S, Weynand B, Lengelé B, Hamoir M: Solitary fibrous tumour of the soft tissue of the face: a case report. B-ENT; 2006;2(4):201-4
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  • [Title] Solitary fibrous tumour of the soft tissue of the face: a case report.
  • INTRODUCTION: Solitary fibrous tumour (SFT) is a rare mesenchymal neoplasm described first in the pleura.
  • Preoperative cytological examination by fine needle aspiration biopsy diagnosed a mesenchymal tumour.
  • Definitive histopathologic and immunohistologic examination confirmed the diagnosis of SFT.
  • DISCUSSION: The rare localisation in extrapleural sites and the multiplicity of histological patterns can explain the difficulty in arriving at a definitive diagnosis in SFT.
  • Usually, SFT is a benign tumour, although malignant variants exist.
  • The recent increase in reports of extrapleural SFT indicates that this rare tumour should be included in the differential diagnosis of soft tissue head and neck tumours.
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Dermatofibrosarcoma / diagnosis. Diagnosis, Differential. Female. Hemangiopericytoma / diagnosis. Humans. Treatment Outcome

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  • (PMID = 17256410.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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17. Ohar JA, Ampleford EJ, Howard SE, Sterling DA: Identification of a mesothelioma phenotype. Respir Med; 2007 Mar;101(3):503-9
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  • Despite the strong association of asbestos exposure to mesothelioma, only a fraction of persons exposed develop this neoplasm which is characterized by long latency and shortened survival.
  • To identify a more extensive set of traits that would define a mesothelioma phenotype for the purpose of genetic analysis, we set to determine characteristics that distinguish mesothelioma patients from others exposed to asbestos and to identify factors that predict the presence of mesothelioma over other mesenchymal tumors of the peritoneum and carcinoma metastatic to the pleura.
  • We compared demographics in four asbestos-exposed groups (controls n=347, bronchogenic cancer n=67, mesothelioma n=179 and benign asbestos-induced lung disease (BALD) n=3757).
  • We found that compared to other asbestos-exposed groups, subjects with mesothelioma were younger at first asbestos exposure, had a greater risk of a second cancer diagnosis (odds ratio=3.29), had a longer disease latency, and had a greater risk of cancer among first-degree relatives (point estimate for risk 2.93; 95% CI 2.5-3.5).
  • Thoracic tumor location, work exposure and male gender were consistently associated with shortened survival (1.9+/-1.3 years).
  • We conclude that thoracic tumor location, work exposure, male gender, long latency, early age at first exposure, presence of a second cancer, and first-degree relative with cancer define a phenotype that sets mesothelioma patients with a short survival apart from other asbestos-exposed individuals.
  • [MeSH-minor] Age Factors. Aged. Educational Status. Family Health. Female. Humans. Male. Middle Aged. Neoplasms, Multiple Primary. Occupational Exposure / adverse effects. Peritoneal Neoplasms / genetics. Peritoneal Neoplasms / mortality. Phenotype. Pleural Neoplasms / genetics. Pleural Neoplasms / mortality. Risk Factors. Sex Factors. Smoking / adverse effects


18. Castellucci P, Perrone AM, Picchio M, Ghi T, Farsad M, Nanni C, Messa C, Meriggiola MC, Pelusi G, Al-Nahhas A, Rubello D, Fazio F, Fanti S: Diagnostic accuracy of 18F-FDG PET/CT in characterizing ovarian lesions and staging ovarian cancer: correlation with transvaginal ultrasonography, computed tomography, and histology. Nucl Med Commun; 2007 Aug;28(8):589-95
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  • AIMS: To (a) assess the accuracy of 18F-FDG PET/CT in distinguishing malignant from benign pelvic lesions, compared to transvaginal ultrasonography (TVUS) and (b) to establish the role of whole-body 18F-FDG PET/CT, compared to contrast enhanced computed tomography (CT), in staging patients with ovarian cancer.
  • RESULTS: At surgery, the ovarian lesions were malignant in 32/50 patients (64%) and benign in the remaining 18/50 patients (36%).
  • CT incorrectly down-staged four out of six stage IV patients by missing distant metastasis in the liver, pleura, mediastinum, and in left supraclavicular lymph nodes, which were correctly detected by 18F-FDG PET/CT.
  • CONCLUSION: PET/CT with 18F-FDG provides additional value to TVUS for the differential diagnosis of benign from malignant pelvic lesions, and to CT for the staging of ovarian cancer patients.
  • [MeSH-major] Ovarian Neoplasms / diagnosis. Positron-Emission Tomography. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Fluorodeoxyglucose F18. Humans. Middle Aged. Neoplasm Staging. Ovarian Diseases / diagnosis. Predictive Value of Tests. Radiopharmaceuticals. Sensitivity and Specificity. Ultrasonography, Doppler, Color

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  • [CommentIn] Nucl Med Commun. 2007 Nov;28(11):879-80; author reply 880 [17901773.001]
  • (PMID = 17625380.001).
  • [ISSN] 0143-3636
  • [Journal-full-title] Nuclear medicine communications
  • [ISO-abbreviation] Nucl Med Commun
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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19. Shibata K, Yuki D, Sakata K: Multiple calcifying fibrous pseudotumors disseminated in the pleura. Ann Thorac Surg; 2008 Feb;85(2):e3-5
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  • [Title] Multiple calcifying fibrous pseudotumors disseminated in the pleura.
  • Calcifying fibrous pseudotumor is an extremely rare benign lesion that develops in the pleura.
  • We describe a case of multiple lesions in the pleura.
  • The diagnosis was established by percutaneous needle biopsy.
  • The largest tumor was hanging down from the parietal pleura, and additional small nodules were disseminated throughout the pleural cavity.
  • [MeSH-major] Calcinosis / pathology. Pleural Diseases / pathology. Thoracic Surgery, Video-Assisted / methods
  • [MeSH-minor] Biopsy, Needle. Female. Follow-Up Studies. Granuloma, Plasma Cell / pathology. Humans. Immunohistochemistry. Middle Aged. Neoplasm Staging. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18222223.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 9
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20. Miyamoto H, Molena DA, Schoeniger LO, Haodong Xu: Solitary fibrous tumor of the pancreas: a case report. Int J Surg Pathol; 2007 Jul;15(3):311-4
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  • [Title] Solitary fibrous tumor of the pancreas: a case report.
  • Solitary fibrous tumor (SFT) is an unusual mesenchymal neoplasm that most often arises in the pleura; however, it has recently been described in a number of extrapleural sites.
  • This report describes an extremely rare case of a benign SFT arising in the pancreas.
  • An endocrine tumor was clinically suspected.
  • Microscopically, the tumor was composed of bland uniform spindle cells arranged between collagen bundles.
  • Based on the light microscopic morphology and immunohistochemical staining profile, the diagnosis of SFT was rendered.
  • [MeSH-major] Neoplasms, Fibrous Tissue / diagnosis. Pancreatic Neoplasms / diagnosis

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  • (PMID = 17652547.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Proto-Oncogene Proteins c-bcl-2
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21. Yamamuro M, Gerbaudo VH, Gill RR, Jacobson FL, Sugarbaker DJ, Hatabu H: Morphologic and functional imaging of malignant pleural mesothelioma. Eur J Radiol; 2007 Dec;64(3):356-66
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  • [Title] Morphologic and functional imaging of malignant pleural mesothelioma.
  • Malignant pleural mesothelioma (MPM) is an aggressive tumor that arises from the pleura and frequently extends to adjacent structures.
  • Major findings include nodular pleural thickening, unilateral pleural effusion, and tumor invasion of adjacent structures.
  • Because of its excellent contrast resolution, MRI is superior to CT, both in the differentiation of malignant from benign pleural disease, and in the assessment of chest wall and diaphragmatic involvement.
  • Perfusion MRI is the most promising technique for the assessment of the tumor microvasculature.
  • It has been shown that FDG-PET is useful for the differentiation of benign from malignant lesions, for staging and monitoring metabolic response to therapy against MPM, and that it has prognostic value.
  • An initial report on PET/CT imaging of MPM has shown increased accuracy of overall staging, improving the assessment of tumor resectability.
  • [MeSH-major] Diagnostic Imaging / methods. Mesothelioma / diagnosis. Pleural Neoplasms / diagnosis
  • [MeSH-minor] Humans. Magnetic Resonance Imaging / methods. Neoplasm Staging. Neovascularization, Pathologic / diagnosis. Positron-Emission Tomography / methods. Tomography, X-Ray Computed / methods


22. Bodtger U, Pedersen JH, Skov BG, Clementsen P: Giant solitary fibrous tumour of the pleura: a rare but usually benign intrathoracic neoplasm. Clin Respir J; 2009 Apr;3(2):109-11
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  • [Title] Giant solitary fibrous tumour of the pleura: a rare but usually benign intrathoracic neoplasm.
  • METHODS: A case report of an 83-year-old women with progressing dyspnoea secondary to a huge left-side neoplasm.
  • RESULTS: Work-up reveal an FEV(1) of 0.4 L, and a giant solitary fibrous tumor of the pleura.
  • The tumor was surgically removed in toto without complications: weighting approximately 3 kg, and benign histology.
  • CONCLUSION: Safe and curative surgery is possible in patients with extrapulmonal neoplasm despite poor FEV(1).
  • [MeSH-major] Solitary Fibrous Tumor, Pleural / pathology. Solitary Fibrous Tumor, Pleural / surgery. Thoracic Surgical Procedures / methods
  • [MeSH-minor] Aged, 80 and over. Biopsy, Needle. Dyspnea / diagnosis. Dyspnea / etiology. Female. Follow-Up Studies. Humans. Immunohistochemistry. Postoperative Care / methods. Preoperative Care / methods. Radiography, Thoracic. Severity of Illness Index. Thoracotomy / methods. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20298386.001).
  • [ISSN] 1752-699X
  • [Journal-full-title] The clinical respiratory journal
  • [ISO-abbreviation] Clin Respir J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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23. Deniz K, Kontas O, Tucer B, Kurtsoy A: Meningeal solitary fibrous tumor: report of a case and literature review. Folia Neuropathol; 2005;43(3):178-85
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  • [Title] Meningeal solitary fibrous tumor: report of a case and literature review.
  • Solitary fibrous tumor is a rare neoplasm that most often involves the pleura.
  • The increasing numbers of this neoplasm have also been reported to date in extrapleural sites.
  • Histologically, the tumor composed of spindle cell proliferation.
  • Tumor cells were found to be positive for CD34 and CD117 with immunohistochemical studies.
  • Seventy seven cases of meningeal solitary fibrous tumor from the literature are analysed and pathological, immunohistochemical and clinical features are discussed.
  • Solitary fibrous tumor has a slight female predominance, with a male to female ratio of 1:1.5.
  • A differential diagnosis is important because most of the solitary fibrous tumors usually behave in a benign fashion.

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  • (PMID = 16245214.001).
  • [ISSN] 1641-4640
  • [Journal-full-title] Folia neuropathologica
  • [ISO-abbreviation] Folia Neuropathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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24. Paiva Nunes A, Mendes I, Godinho T, Lourenço I, Jordão A, Gorjão Clara J: [Solitary fibrous tumor of the pleura]. Rev Port Cir Cardiotorac Vasc; 2007 Oct-Dec;14(4):203-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Solitary fibrous tumor of the pleura].
  • [Transliterated title] Tumor fibroso solitário da pleura.
  • Solitary fibrous tumors of the pleura are rare tumors originating from the mesenchymal cells of the submesothelial tissue of the pleura.
  • In half of the cases, the neoplasm presents as an asymptomatic mass, often with quite large dimensions.
  • It is a benign tumor in 80% of the cases and even when considered malignant has a good prognosis if totally removed.
  • We present the case of a 78-year-old female, who was evaluated for lower respiratory infection, in whom the diagnosis of Giant Solitary Fibrous Tumor of the Pleura was made.
  • [MeSH-major] Solitary Fibrous Tumor, Pleural

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  • (PMID = 18408817.001).
  • [ISSN] 0873-7215
  • [Journal-full-title] Revista portuguesa de cirurgia cardio-torácica e vascular : órgão oficial da Sociedade Portuguesa de Cirurgia Cardio-Torácica e Vascular
  • [ISO-abbreviation] Rev Port Cir Cardiotorac Vasc
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Portugal
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25. Martínez Martínez P, Moldes Rodríguez M, Moreno Mata N, Simón Adiego C, Cebollero Presmanes M, González Aragoneses F: [Immunohistochemistry and surgical approaches in solitary fibrous tumor of the pleura]. Cir Esp; 2007 Mar;81(3):155-8
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  • [Title] [Immunohistochemistry and surgical approaches in solitary fibrous tumor of the pleura].
  • [Transliterated title] Inmunohistoquímica y vías de abordaje en el tumor fibroso pleural.
  • Solitary fibrous tumor of the pleura (SFTP) is a rare, benign, slow-growing neoplasm that arises from the submesothelial cells of the pleura.
  • Usually, resection of the tumor and adjacent structures are sufficient for resolution.
  • Only four patients were symptomatic at diagnosis.
  • Because of the malignant potential of this tumor, long-term follow-up is mandatory.
  • [MeSH-major] Neoplasms, Fibrous Tissue / immunology. Neoplasms, Fibrous Tissue / surgery. Pleural Neoplasms / immunology. Pleural Neoplasms / surgery. Thoracic Surgery, Video-Assisted / instrumentation
  • [MeSH-minor] Adult. Aged. Antigens, CD34 / immunology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Mesothelioma / immunology. Mesothelioma / pathology. Mesothelioma / surgery. Middle Aged

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  • (PMID = 17349242.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antigens, CD34
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26. Kotoulas C, Fotinou M, Tsaroucha E, Konstantinou M, Lioulias A: Images in cardiothoracic surgery. Localized fibrous mesothelioma: an extremely rare benign pleural tumor. Ann Thorac Surg; 2006 Jun;81(6):2316
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  • [Title] Images in cardiothoracic surgery. Localized fibrous mesothelioma: an extremely rare benign pleural tumor.
  • [MeSH-major] Mesothelioma / radiography. Pleural Neoplasms / radiography. Tomography, X-Ray Computed

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  • (PMID = 16731187.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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27. Way TW, Hadjiiski LM, Sahiner B, Chan HP, Cascade PN, Kazerooni EA, Bogot N, Zhou C: Computer-aided diagnosis of pulmonary nodules on CT scans: segmentation and classification using 3D active contours. Med Phys; 2006 Jul;33(7):2323-37
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  • [Title] Computer-aided diagnosis of pulmonary nodules on CT scans: segmentation and classification using 3D active contours.
  • We are developing a computer-aided diagnosis (CAD) system to classify malignant and benign lung nodules found on CT scans.
  • A data set of 96 lung nodules (44 malignant, 52 benign) from 58 patients was used in this study.
  • (1) 3D gradient, which guides the active contour to seek the object surface, (2) 3D curvature, which imposes a smoothness constraint in the z direction, and (3) mask energy, which penalizes contours that grow beyond the pleura or thoracic wall.
  • [MeSH-major] Diagnosis, Computer-Assisted / methods. Lung Neoplasms / diagnosis. Lung Neoplasms / diagnostic imaging. Solitary Pulmonary Nodule / diagnosis. Solitary Pulmonary Nodule / diagnostic imaging. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Biopsy. False Positive Reactions. Humans. Image Processing, Computer-Assisted / methods. Imaging, Three-Dimensional. Models, Statistical. Neoplasm Metastasis. ROC Curve

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  • (PMID = 16898434.001).
  • [ISSN] 0094-2405
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 93517; United States / NCI NIH HHS / CA / R01 CA093517-05; United States / NCI NIH HHS / CA / R01 CA095153-05; United States / NCI NIH HHS / CA / R01 CA095153; United States / NCI NIH HHS / CA / R01 CA093517
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS129058; NLM/ PMC2728558
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28. Madhuvrata P, Jayachandran MC, Edmonds DK, Agarwal S, El-Bahrawy M: Retroperitoneal solitary fibrous tumour arising from the pelvis in women--a case report and review of literature. J Obstet Gynaecol; 2005 Feb;25(2):189-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Retroperitoneal solitary fibrous tumour arising from the pelvis in women--a case report and review of literature.
  • A solitary fibrous tumour is an unusual spindle cell neoplasm that most frequently occurs in the pleura based intrathoracic region.
  • They are usually benign but malignant solitary fibrous tumours have also been reported (Nielson et al. 1997).
  • There is far less information about the clinical behaviour of an extra thoracic solitary fibrous tumour unlike intrathoracic tumours which is well reported in many case series (England et al. 1989).
  • [MeSH-major] Fibroma / diagnosis. Retroperitoneal Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Pelvis. Postmenopause

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  • (PMID = 15814404.001).
  • [ISSN] 0144-3615
  • [Journal-full-title] Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
  • [ISO-abbreviation] J Obstet Gynaecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 12
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29. Znati K, Chbani L, El Fatemi H, Harmouch T, Kamaoui I, Tazi F, Bennis S, Amarti A: Solitary fibrous tumor of the kidney: a case report and review of the literature. Rev Urol; 2007;9(1):36-40
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  • [Title] Solitary fibrous tumor of the kidney: a case report and review of the literature.
  • A solitary fibrous tumor (SFT) is an unusual spindle cell neoplasm that usually occurs in the pleura but has recently been described in diverse extrapleural sites.
  • The tumor was well circumscribed and composed of a mixture of spindle cells and dense collagenous bands, with areas of necrosis or cystic changes noted macroscopically and microscopically.
  • Immunohistochemical studies revealed reactivity for CD34, CD99, and Bcl-2 protein, with no staining for keratin, S-100 protein, or muscle markers, confirming the diagnosis of SFT.
  • This tumor is benign in up to 90% of cases.
  • The immunohistochemical study is the key to diagnosis.

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  • (PMID = 17396171.001).
  • [ISSN] 1523-6161
  • [Journal-full-title] Reviews in urology
  • [ISO-abbreviation] Rev Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1831532
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30. Białas M, Szczepański W, Szpor J, Okoń K, Kostecka-Matyja M, Hubalewska-Dydejczyk A, Tomaszewska R: Adenomatoid tumour of the adrenal gland: a case report and literature review. Pol J Pathol; 2010;61(2):97-102
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  • [Title] Adenomatoid tumour of the adrenal gland: a case report and literature review.
  • Adenomatoid tumour (AT) is a rare, benign neoplasm of mesothelial origin, which usually occurs in the genital tract of both sexes.
  • Occasionally these tumours are found in extra genital locations such as heart, pancreas, skin, pleura, omentum, lymph nodes, retroperitoneum, intestinal mesentery and adrenal gland.
  • The tumour was an incidental finding during abdominal CT-scan for an unrelated condition.
  • We also present a review of the literature concerning adrenal gland AT and give possible differential diagnosis.
  • [MeSH-major] Adenomatoid Tumor / pathology. Adrenal Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Asymptomatic Diseases. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Incidental Findings. Male. Radiography, Abdominal. Tomography, X-Ray Computed

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  • (PMID = 20924994.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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31. Guinee DG, Allen TC: Primary pleural neoplasia: entities other than diffuse malignant mesothelioma. Arch Pathol Lab Med; 2008 Jul;132(7):1149-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary pleural neoplasia: entities other than diffuse malignant mesothelioma.
  • CONTEXT: Overwhelmingly, the most common neoplasm involving the pleura is metastatic carcinoma.
  • In contrast, diffuse malignant mesothelioma occurs relatively rarely; however, it is nonetheless the most common neoplasm primary to the pleura.
  • Other primary pleural neoplasms occur uncommonly or rarely, with their own prognostic and therapeutic characteristics.
  • OBJECTIVE: To review primary pleural neoplasms other than diffuse malignant mesothelioma, to better ensure correct diagnosis and optimal assessment of prognosis and treatment.
  • CONCLUSIONS: A nonexhaustive group of uncommon to rare benign and malignant primary pleural neoplasms--other than diffuse malignant mesothelioma--are presented, of which one must be aware in order to maintain an appropriate index of suspicion to include them in the differential diagnosis of a pleural tumor.
  • [MeSH-major] Pleural Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Prognosis

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  • (PMID = 18605768.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 244
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32. Wang W, Quan CB, Li N, Wang XJ, Song JY, Jia SL, Lin MG: [Diagnosis of pleural cavity extraskeletal osteosarcoma: a case report and literature review]. Zhonghua Jie He He Hu Xi Za Zhi; 2010 Mar;33(3):202-5
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  • [Title] [Diagnosis of pleural cavity extraskeletal osteosarcoma: a case report and literature review].
  • OBJECTIVE: To describe the manifestations and diagnosis of pleural cavity extraskeletal osteosarcoma (ESO).
  • RESULTS: Chest CT of a middle-aged man revealed an enormous heterogeneous neoplasm, about 10.9 cm x 9.2 cm x 17.7 cm in size, in the left pleural cavity.
  • There was abundant calcification in the tumor, with signs of invasion into the diaphragm and the pleura.
  • Pleural effusion of the left thoracic cavity was also seen on the chest CT.
  • Osteosarcoma was confirmed by pathological study after surgical resection of the tumor.
  • Pleural cavity ESO is insidious and imaging studies often reveal a huge mass with abundant calcification.
  • The differential diagnosis includes benign and malignant diseases of the thorax.
  • [MeSH-major] Osteosarcoma. Pleural Cavity / pathology

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  • (PMID = 20450640.001).
  • [ISSN] 1001-0939
  • [Journal-full-title] Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
  • [ISO-abbreviation] Zhonghua Jie He He Hu Xi Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] China
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33. Granville L, Laga AC, Allen TC, Dishop M, Roggli VL, Churg A, Zander DS, Cagle PT: Review and update of uncommon primary pleural tumors: a practical approach to diagnosis. Arch Pathol Lab Med; 2005 Nov;129(11):1428-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Review and update of uncommon primary pleural tumors: a practical approach to diagnosis.
  • OBJECTIVE: We address the current classifications and new changes regarding uncommon primary pleural tumors.
  • Primary pleural tumors are divided according to their behavior and are discussed separately as benign tumors, tumors of low malignant potential, and malignant neoplasms.
  • DATA SOURCES: Current literature concerning primary pleural neoplasms was collected and reviewed.
  • STUDY SELECTION: Studies emphasizing clinical, radiological, or pathologic findings of primary pleural neoplasms were obtained.
  • DATA EXTRACTION: Data deemed helpful to the general surgical pathologist when confronted with an uncommon primary pleural tumor was included in this review.
  • (1) benign, (2) low malignant potential, and (3) malignant.
  • A practical approach to the diagnosis of these neoplasms in surgical pathology specimens is offered.
  • The differential diagnosis, including metastatic pleural neoplasms, is also briefly addressed.
  • CONCLUSIONS: Uncommon primary pleural neoplasms may mimic each other, as well as mimic metastatic cancers to the pleura and diffuse malignant mesothelioma.
  • Correct diagnosis is important because of different prognosis and treatment implications for the various neoplasms.
  • [MeSH-major] Medical Oncology / methods. Mesothelioma / pathology. Neoplasm Metastasis / pathology. Pleural Neoplasms / pathology
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Humans. Pleura / pathology

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  • (PMID = 16253024.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Review
  • [Publication-country] United States
  • [Number-of-references] 131
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34. Kawamura S, Nakamura T, Oya T, Ishizawa S, Sakai Y, Tanaka T, Saito S, Fukuoka J: Advanced malignant solitary fibrous tumor in pelvis responding to radiation therapy. Pathol Int; 2007 Apr;57(4):213-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Advanced malignant solitary fibrous tumor in pelvis responding to radiation therapy.
  • Solitary fibrous tumor (SFT) is a rare spindle cell neoplasm that is benign in most cases.
  • Although SFT was first recognized to arise only in the pleura, recent reports indicate that SFT can involve a wide range of anatomical sites.
  • Along with massive invasion to adjacent organs and multiple lung metastases detected on radiography, biopsy from the tumor through the vaginal wall showed malignant looking spindle-cell neoplasm with increased cellularity, areas of necrosis, and high mitotic activity (5/10 high-power fields).
  • Immunohistochemically, the tumor cells were diffusely and strongly positive for CD34, CD99, and bcl-2.
  • Based on pathological features and clinical presentation, diagnosis of malignant SFT was made.
  • Initial chemotherapies failed to control the tumor.
  • [MeSH-minor] Aged. Disease Progression. Female. Humans. Magnetic Resonance Imaging. Neoplasm Metastasis / pathology

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  • (PMID = 17316417.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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35. Seyfarth HJ, Wirtz H, Borte G, Gradistanac T, Gessner C, Hammerschmidt S: [Ultrasound guided transthoracic biopsy - safety and efficaces]. Pneumologie; 2007 Sep;61(9):563-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The biopsy of pulmonary neoplasms localized in close proximity of the thoracic wall and the histological examination of the specimens represent an important diagonstic tool in the work up of benign and malign pulmonary tumours.
  • 43 pulmonary or pleural and 3 mediastinal neoplasms were investigated.
  • The neoplasm reached the pleura in 41 cases.
  • RESULTS: The histological examination provided the diagnosis in 44 of 46 cases (95.6 %): lung cancer n = 29, other malign tumours n = 9; benign tumours n = 6).

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  • (PMID = 17602390.001).
  • [ISSN] 1438-8790
  • [Journal-full-title] Pneumologie (Stuttgart, Germany)
  • [ISO-abbreviation] Pneumologie
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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36. Cagle PT, Churg A: Differential diagnosis of benign and malignant mesothelial proliferations on pleural biopsies. Arch Pathol Lab Med; 2005 Nov;129(11):1421-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential diagnosis of benign and malignant mesothelial proliferations on pleural biopsies.
  • CONTEXT: Although much of the pathology literature focuses on differential diagnosis of diffuse malignant mesothelioma from other types of cancer, the primary diagnostic challenge facing the pathologist is often whether a mesothelial proliferation on a pleural biopsy represents a malignancy or a benign reactive hyperplasia.
  • DESIGN: Based on previous medical publications, extensive personal consultations, and experience on the United States-Canadian Mesothelioma Reference Panel and the International Mesothelioma Panel, salient information was determined about interpretation of benign versus malignant mesothelial proliferations on pleural biopsies.
  • RESULTS: Differentiation of benign reactive mesothelial hyperplasia from diffuse malignant mesothelioma is often difficult.
  • Benign reactive mesothelial hyperplasia may mimic many features ordinarily associated with malignancy, and diffuse malignant mesothelioma may be cytologically bland.
  • Entrapment of benign reactive mesothelial cells within organizing pleuritis may mimic tissue invasion.
  • CONCLUSIONS: Various histologic clues favor a benign over a malignant mesothelial proliferation and vice versa.
  • When there is any doubt that a pleural biopsy represents a malignancy, we recommend a diagnosis of atypical mesothelial proliferation.
  • [MeSH-major] Epithelium / pathology. Mesothelioma / pathology. Pleura / pathology. Pleural Neoplasms / pathology
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Humans. Hyperplasia / pathology. Neoplasm Invasiveness

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  • (PMID = 16253023.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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