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1. Koch M, Habazettl I, Dehghani F, Korf HW: The rat pineal gland comprises an endocannabinoid system. J Pineal Res; 2008 Nov;45(4):351-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The rat pineal gland comprises an endocannabinoid system.
  • In the mammalian pineal gland, the rhythm in melatonin biosynthesis depends on the norepinephrine (NE)-driven regulation of arylalkylamine N-acetyltransferase (AANAT), the penultimate enzyme of melatonin biosynthesis.
  • A recent study showed that phytocannabinoids like tetrahydrocannabinol reduce AANAT activity and attenuate NE-induced melatonin biosynthesis in rat pineal glands, raising the possibility that an endocannabinoid system is present in the pineal gland.
  • To test this hypothesis, we analyzed cannabinoid (CB) receptors and specific enzymes for endocannabinoid biosynthesis or catabolism in rat pineal glands and cultured pinealocytes.
  • Immunohistochemical and immunoblot analyses revealed the presence of CB1 and CB2 receptor proteins, of N-acyl phosphatidyl ethanolamine hydrolyzing phospholipase D (NAPE-PLD), an enzyme catalyzing endocannabinoid biosynthesis and of fatty acid amide hydrolase (FAAH), an endocannabinoid catabolizing enzyme, in pinealocytes, and in pineal sympathetic nerve fibers identified by double immunofluorescence with an antibody against tyrosine hydroxylase.
  • The immunosignal for NAPE-PLD found in pineal sympathetic nerve fibers was reduced in the middle of the dark phase (ZT 18).
  • Stimulation of cultured pinealocytes with NE affected neither the subcellular distribution nor the intensity of the immunosignals for the investigated CB receptors and enzymes.
  • In summary, the pineal gland comprises indispensable compounds of the endocannabinoid system indicating that endocannabinoids may be involved in the control of pineal physiology.
  • [MeSH-major] Adrenergic Fibers / chemistry. Cannabinoid Receptor Modulators / analysis. Endocannabinoids. Pineal Gland / chemistry. Receptor, Cannabinoid, CB1 / analysis. Receptor, Cannabinoid, CB2 / analysis

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  • (PMID = 18554250.001).
  • [ISSN] 1600-079X
  • [Journal-full-title] Journal of pineal research
  • [ISO-abbreviation] J. Pineal Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Cannabinoid Receptor Modulators; 0 / Endocannabinoids; 0 / Receptor, Cannabinoid, CB1; 0 / Receptor, Cannabinoid, CB2; EC 1.14.16.2 / Tyrosine 3-Monooxygenase; EC 3.1.4.4 / NAPE-PLD protein, rat; EC 3.1.4.4 / Phospholipase D; EC 3.5.- / Amidohydrolases; EC 3.5.1.- / fatty-acid amide hydrolase; X4W3ENH1CV / Norepinephrine
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2. Leveque S, Derrey S, Martinaud O, Freger P, Proust F: [Pineal cyst: usefulness of endoscopic treatment]. Neurochirurgie; 2007 Jun;53(2-3 Pt 1):95-9
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  • [Title] [Pineal cyst: usefulness of endoscopic treatment].
  • [Transliterated title] Kyste épithélial de la région pinéale: intérêt de la fenestration endoscopique.
  • Glial cysts of the pineal gland are usually benign and asymptomatic.
  • They develop from the pineal parenchyma and contain liquid.
  • The diagnosis is made by magnetic resonance imaging.
  • [MeSH-major] Brain Neoplasms / pathology. Brain Neoplasms / surgery. Endoscopy / methods. Neurosurgical Procedures / methods. Pineal Gland / pathology. Pineal Gland / surgery

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  • (PMID = 17507051.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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3. Abraham U, Prior JL, Granados-Fuentes D, Piwnica-Worms DR, Herzog ED: Independent circadian oscillations of Period1 in specific brain areas in vivo and in vitro. J Neurosci; 2005 Sep 21;25(38):8620-6
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  • Surgery reliably reset the phase of the pineal gland and vascular organ of the lamina terminalis (VOLT) harvested from SCNX rats but had little effect on the phase of the OB.
  • We deduce that the SCN and OB contain self-sustained circadian oscillators, whereas the pineal gland and VOLT are weak oscillators that require input from the SCN to show coordinated circadian rhythms.

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  • (PMID = 16177029.001).
  • [ISSN] 1529-2401
  • [Journal-full-title] The Journal of neuroscience : the official journal of the Society for Neuroscience
  • [ISO-abbreviation] J. Neurosci.
  • [Language] eng
  • [Grant] United States / NIMH NIH HHS / MH / MH63104; United States / NCI NIH HHS / CA / P50 CA94056
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Nuclear Proteins; 0 / Per1 protein, mouse; 0 / Per1 protein, rat; 0 / Period Circadian Proteins
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4. Ferreira ZS, Fernandes PA, Duma D, Assreuy J, Avellar MC, Markus RP: Corticosterone modulates noradrenaline-induced melatonin synthesis through inhibition of nuclear factor kappa B. J Pineal Res; 2005 Apr;38(3):182-8
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  • In chronically inflamed animals, adrenal hormones exert a positive control on the secretion of melatonin by the pineal gland.
  • In this paper, the mechanism of corticosterone as a modulator of melatonin and N-acetylserotonin (NAS) was determined.
  • Rat pineal glands in culture, stimulated for 5 hr with noradrenaline (10 nm), were previously incubated with corticosterone (1.0 nm-1.0 microm) for 48 hr in the presence or absence of the glucocorticoid receptor (GR) antagonist, mifepristone (1.0 microm), the proteasome inhibitor, N-acetyl-leucinyl-leucinyl-norleucinal-H (ALLN, 12.5 microm) or the antagonist of the nuclear factor kappa B (NFkappaB), pyrrolidinedithiocarbamate (PDTC, 12.5 microm).
  • Corticosterone potentiated noradrenaline-induced melatonin and NAS production in a bell-shaped manner.
  • The increase in NAS (12.9 +/- 2.7, n=6 versus 34.3 +/- 8.3 ng per pineal) and melatonin (16.3 +/- 2.0, n=6 versus 44.3 +/- 12.9 ng per pineal) content induced by 1 microm corticosterone was blocked by mifepristone, and mimicked by ALLN and PDTC.
  • Therefore, corticosterone potentiates noradrenaline-induced melatonin and NAS production through GR inhibition of NFkappaB nuclear translocation.
  • To the best of our knowledge, this is the first time that this relevant pathway for passive and acquired immune response is shown to modulate melatonin production in pineal gland.
  • [MeSH-major] Corticosterone / pharmacology. Melatonin / biosynthesis. NF-kappa B / antagonists & inhibitors. Norepinephrine / pharmacology. Pineal Gland / drug effects. Pineal Gland / metabolism. Serotonin / analogs & derivatives

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  • (PMID = 15725340.001).
  • [ISSN] 0742-3098
  • [Journal-full-title] Journal of pineal research
  • [ISO-abbreviation] J. Pineal Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Hormone Antagonists; 0 / Leupeptins; 0 / NF-kappa B; 0 / Pyrrolidines; 0 / Receptors, Glucocorticoid; 0 / Thiocarbamates; 110044-82-1 / acetylleucyl-leucyl-norleucinal; 25769-03-3 / pyrrolidine dithiocarbamic acid; 320T6RNW1F / Mifepristone; 333DO1RDJY / Serotonin; 7S5I7G3JQL / Dexamethasone; 9007-49-2 / DNA; JL5DK93RCL / Melatonin; P4TO3C82WV / N-acetylserotonin; W980KJ009P / Corticosterone; X4W3ENH1CV / Norepinephrine
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5. Esposito E, Cuzzocrea S: Antiinflammatory activity of melatonin in central nervous system. Curr Neuropharmacol; 2010 Sep;8(3):228-42
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  • Melatonin is mainly produced in the mammalian pineal gland during the dark phase.
  • Its secretion from the pineal gland has been classically associated with circadian and circanual rhythm regulation.
  • However, melatonin production is not confined exclusively to the pineal gland, but other tissues including retina, Harderian glands, gut, ovary, testes, bone marrow and lens also produce it.

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  • [Cites] J Pineal Res. 2008 Aug;45(1):1-7 [18194199.001]
  • [Cites] J Physiol Pharmacol. 2007 Dec;58 Suppl 6:5-22 [18212398.001]
  • [Cites] J Physiol Pharmacol. 2007 Dec;58 Suppl 6:115-24 [18212405.001]
  • [Cites] Adv Med Sci. 2007;52:11-28 [18217386.001]
  • [Cites] J Pineal Res. 2008 Sep;45(2):157-65 [18298462.001]
  • [Cites] J Pineal Res. 2008 Sep;45(2):149-56 [18298463.001]
  • [Cites] J Pineal Res. 2008 Sep;45(2):191-8 [18318704.001]
  • [Cites] J Pineal Res. 2008 Apr;44(3):234-43 [18339118.001]
  • [Cites] J Pineal Res. 2008 Oct;45(3):235-46 [18341517.001]
  • [Cites] J Pineal Res. 2008 Nov;45(4):373-82 [18482339.001]
  • [Cites] J Pineal Res. 2008 Nov;45(4):497-505 [18705649.001]
  • [Cites] Mol Med. 2009 Jan-Feb;15(1-2):43-50 [19011689.001]
  • [Cites] J Pineal Res. 2009 Mar;46(2):188-98 [19054298.001]
  • [Cites] J Vet Med Sci. 2008 Nov;70(11):1219-23 [19057141.001]
  • [Cites] J Pineal Res. 2009 Jan;46(1):79-86 [19090911.001]
  • [Cites] J Pineal Res. 2009 Jan;46(1):95-105 [19090912.001]
  • [Cites] J Pineal Res. 2009 Jan;46(1):106-14 [19090913.001]
  • [Cites] Mol Cell Endocrinol. 1991 Aug;79(1-3):C153-8 [1936532.001]
  • [Cites] FASEB J. 1995 Apr;9(7):526-33 [7737461.001]
  • [Cites] J Neurochem. 2006 Sep;98(6):2023-33 [16945113.001]
  • [Cites] Annu Rev Cell Dev Biol. 2001;17:463-516 [11687497.001]
  • [Cites] Croat Med J. 2002 Feb;43(1):28-32 [11828555.001]
  • [Cites] Acta Pharmacol Sin. 2002 Feb;23(2):183-7 [11866882.001]
  • [Cites] Curr Top Med Chem. 2002 Feb;2(2):181-97 [11899100.001]
  • [Cites] Nat Rev Mol Cell Biol. 2002 Mar;3(3):207-14 [11994741.001]
  • [Cites] J Pineal Res. 2002 Apr;32(3):135-42 [12074096.001]
  • [Cites] J Spinal Cord Med. 2002 Summer;25(2):70-9; discussion 80 [12137220.001]
  • [Cites] J Pineal Res. 2002 Nov;33(4):204-12 [12390502.001]
  • [Cites] Neurobiol Aging. 2002 Sep-Oct;23(5):795-807 [12392783.001]
  • [Cites] J Pineal Res. 2003 Jan;34(1):75-8 [12485375.001]
  • [Cites] FASEB J. 2003 May;17(8):932-4 [12670878.001]
  • [Cites] J Neurochem. 2003 Jul;86(1):228-37 [12807442.001]
  • [Cites] Redox Rep. 2003;8(4):205-13 [14599344.001]
  • [Cites] Adv Exp Med Biol. 2003;543:191-200 [14713123.001]
  • [Cites] FASEB J. 2004 May;18(7):869-71 [15033929.001]
  • [Cites] J Pineal Res. 2004 Aug;37(1):11-6 [15230863.001]
  • [Cites] J Pineal Res. 2004 Aug;37(1):55-70 [15230869.001]
  • [Cites] J Pineal Res. 2004 Sep;37(2):129-36 [15298672.001]
  • [Cites] J Pineal Res. 2005 Oct;39(3):287-93 [16150110.001]
  • [Cites] Endocrine. 2005 Jul;27(2):111-8 [16217124.001]
  • [Cites] Free Radic Biol Med. 2006 Jan 1;40(1):101-9 [16337883.001]
  • [Cites] Acta Pharmacol Sin. 2006 Jan;27(1):41-9 [16364209.001]
  • [Cites] J Pineal Res. 2005 Jan;38(1):1-9 [15617531.001]
  • [Cites] Life Sci. 2006 Oct 12;79(20):1895-905 [16978658.001]
  • [Cites] J Neurosci. 2006 Sep 27;26(39):9841-50 [17005848.001]
  • [Cites] J Bioenerg Biomembr. 1999 Dec;31(6):609-16 [10682918.001]
  • [Cites] Neuroreport. 2000 Apr 7;11(5):923-6 [10790856.001]
  • [Cites] Biochem Mol Biol Int. 1995 Dec;37(6):1063-70 [8747536.001]
  • [Cites] Brain Pathol. 1995 Oct;5(4):407-13 [8974623.001]
  • [Cites] J Exp Med. 1996 Dec 1;184(6):2311-26 [8976186.001]
  • [Cites] N Engl J Med. 1997 Apr 10;336(15):1066-71 [9091804.001]
  • [Cites] J Cell Biochem. 1997 Jun 1;65(3):430-42 [9138098.001]
  • [Cites] Front Biosci. 1997 Mar 1;2:d88-125 [9159216.001]
  • [Cites] J Neurochem. 1997 Jun;68(6):2227-40 [9166714.001]
  • [Cites] Eur J Pharmacol. 2005 Mar 7;510(1-2):25-30 [15740721.001]
  • [Cites] Acta Pharmacol Sin. 2005 May;26(5):519-26 [15842767.001]
  • [Cites] Neurosci Lett. 2005 May 20-27;380(1-2):26-31 [15854745.001]
  • [Cites] J Neuroimmunol. 2005 Aug;165(1-2):139-49 [15975667.001]
  • [Cites] Free Radic Biol Med. 2005 Aug 15;39(4):549-57 [16043026.001]
  • [Cites] J Pineal Res. 2005 Sep;39(2):99-104 [16098085.001]
  • [Cites] J Pineal Res. 2005 Oct;39(3):251-60 [16150105.001]
  • [Cites] Restor Neurol Neurosci. 1998;13(3-4):185-91 [12671279.001]
  • [Cites] J Neurotrauma. 2003 Feb;20(2):207-19 [12675973.001]
  • [Cites] Best Pract Res Clin Endocrinol Metab. 2003 Jun;17(2):273-85 [12787552.001]
  • [Cites] Free Radic Res. 2003 May;37(5):543-53 [12797476.001]
  • [Cites] Spinal Cord. 2003 Jul;41(7):369-78 [12815368.001]
  • [Cites] Spine (Phila Pa 1976). 2003 Aug 1;28(15):1643-52 [12897486.001]
  • [Cites] Spine J. 2002 Mar-Apr;2(2):116-28 [14588270.001]
  • [Cites] J Pineal Res. 2006 Nov;41(4):313-23 [17014688.001]
  • [Cites] J Pineal Res. 2006 Nov;41(4):337-43 [17014690.001]
  • [Cites] J Pineal Res. 2006 Nov;41(4):374-81 [17014695.001]
  • [Cites] Neurobiol Aging. 2008 Feb;29(2):203-9 [17097768.001]
  • [Cites] Mol Cell Biochem. 2007 Apr;298(1-2):69-81 [17136482.001]
  • [Cites] Free Radic Res. 2007 Jan;41(1):15-24 [17164175.001]
  • [Cites] J Pineal Res. 2007 Jan;42(1):1-11 [17198533.001]
  • [Cites] J Pineal Res. 2007 Jan;42(1):28-42 [17198536.001]
  • [Cites] J Pineal Res. 2007 Apr;42(3):272-9 [17349026.001]
  • [Cites] J Pineal Res. 2007 Apr;42(4):386-93 [17439555.001]
  • [Cites] J Pineal Res. 2007 Aug;43(1):56-64 [17614836.001]
  • [Cites] Genes Brain Behav. 2008 Mar;7(2):129-51 [17680806.001]
  • [Cites] J Pineal Res. 2007 Nov;43(4):317-20 [17910598.001]
  • [Cites] J Pineal Res. 2007 Nov;43(4):382-8 [17910607.001]
  • [Cites] J Pineal Res. 2007 Nov;43(4):389-403 [17910608.001]
  • [Cites] J Pineal Res. 2008 May;44(4):348-57 [18086148.001]
  • [Cites] J Pineal Res. 2007 Sep;43(2):195-205 [17645698.001]
  • [Cites] J Pineal Res. 2008 Jan;44(1):101-6 [18078455.001]
  • [Cites] J Neurochem. 2008 May;105(3):628-40 [18248364.001]
  • [Cites] Exp Gerontol. 2008 Aug;43(8):749-56 [18485648.001]
  • [Cites] Int J Med Sci. 2008;5(3):127-32 [18566676.001]
  • [Cites] Neuroimmunomodulation. 2008;15(2):93-101 [18679047.001]
  • [Cites] Neuro Endocrinol Lett. 2008 Aug;29(4):391-8 [18766165.001]
  • [Cites] Stroke. 2009 May;40(5):1877-85 [19299628.001]
  • [Cites] Rev Endocr Metab Disord. 2009 Dec;10(4):237-43 [20024626.001]
  • [Cites] J Neural Transm Suppl. 1978;(13):311-23 [288855.001]
  • [Cites] Biochem Biophys Res Commun. 1987 Jun 30;145(3):1231-8 [2955784.001]
  • [Cites] Semin Thromb Hemost. 1987 Oct;13(4):425-33 [3122325.001]
  • [Cites] Am J Hosp Pharm. 1977 May;34(5):479-85 [326041.001]
  • [Cites] Paraplegia. 1987 Jun;25(3):225-8 [3601432.001]
  • [Cites] J Comp Neurol. 1980 Dec 1;194(3):639-48 [7451686.001]
  • [Cites] Brain Res. 1994 Jul 18;651(1-2):92-100 [7522935.001]
  • [Cites] J Biol Chem. 1995 Mar 31;270(13):7037-40 [7706239.001]
  • [Cites] Trends Pharmacol Sci. 1995 Mar;16(3):81-3 [7792932.001]
  • [Cites] J Pineal Res. 1994 Sep;17(2):55-62 [7869228.001]
  • [Cites] J Pineal Res. 2009 Sep;47(2):184-91 [19627457.001]
  • [Cites] J Biol Chem. 1974 Feb 25;249(4):1311-3 [4814344.001]
  • [Cites] Neuroscience. 1984 Mar;11(3):595-603 [6717804.001]
  • [Cites] Nature. 1995 Apr 20;374(6524):733-6 [7715730.001]
  • [Cites] N Engl J Med. 1995 Jul 20;333(3):142-6 [7791815.001]
  • [Cites] J Neurosci. 1997 Mar 1;17(5):1683-90 [9030627.001]
  • [Cites] FEBS Lett. 1997 Oct 13;416(1):103-6 [9369243.001]
  • [Cites] Brain Res. 1997 Sep 12;768(1-2):317-26 [9369331.001]
  • [Cites] J Pineal Res. 1997 Sep;23(2):106-16 [9392449.001]
  • [Cites] J Pineal Res. 1998 Jan;24(1):15-21 [9468114.001]
  • [Cites] Stroke. 1998 Oct;29(10):2189-95 [9756602.001]
  • [Cites] Brain Res. 1999 Jan 23;816(2):276-85 [9878784.001]
  • [Cites] J Clin Endocrinol Metab. 1999 Jan;84(1):323-7 [9920102.001]
  • [Cites] Eur J Pharmacol. 1998 Dec 11;363(1):57-63 [9877082.001]
  • [Cites] Zhongguo Yao Li Xue Bao. 1999 May;20(5):409-14 [10678086.001]
  • [Cites] Experientia. 1993 Aug 15;49(8):635-41 [8359270.001]
  • [Cites] Arthritis Rheum. 1993 Jan;36(1):51-8 [8424836.001]
  • [Cites] Ann Emerg Med. 1993 Jun;22(6):987-92 [8503537.001]
  • [Cites] Neuroscience. 1993 May;54(1):5-9 [8515846.001]
  • [Cites] Neurology. 1996 Jun;46(6):1626-32 [8649561.001]
  • [Cites] FASEB J. 1996 Jun;10(8):882-90 [8666165.001]
  • [Cites] Pharmacol Biochem Behav. 1996 May;54(1):299-303 [8728571.001]
  • [Cites] Mol Psychiatry. 1997 Jul;2(4):300-10 [9246670.001]
  • [Cites] Brain Res. 1997 Jul 11;762(1-2):173-84 [9262171.001]
  • [Cites] J Biol Rhythms. 1997 Dec;12(6):528-31 [9406026.001]
  • [Cites] FASEB J. 1998 Jun;12(9):685-93 [9619447.001]
  • [Cites] J Neurosci Res. 1998 Aug 1;53(3):368-76 [9698165.001]
  • [Cites] Inflamm Res. 1998 Oct;47 Suppl 2:S78-87 [9831328.001]
  • [Cites] J Neurosci Res. 1999 Mar 1;55(5):542-56 [10082077.001]
  • [Cites] Biol Signals Recept. 1999 Jan-Apr;8(1-2):56-63 [10085463.001]
  • [Cites] Biochim Biophys Acta. 1999 May 5;1411(2-3):401-14 [10320672.001]
  • [Cites] J Neurosci. 1999 Jun 15;19(12):4994-5004 [10366632.001]
  • [Cites] FASEB J. 1999 Sep;13(12):1537-46 [10463945.001]
  • [Cites] Biochim Biophys Acta. 1999 Oct 18;1472(1-2):206-14 [10572942.001]
  • [Cites] Metab Brain Dis. 1999 Sep;14(3):165-71 [10646692.001]
  • [Cites] Ann N Y Acad Sci. 1999;890:471-85 [10668453.001]
  • [Cites] Spine (Phila Pa 1976). 2000 Apr 1;25(7):769-75 [10751286.001]
  • [Cites] J Neural Transm (Vienna). 2000;107(2):203-31 [10847561.001]
  • [Cites] Biol Signals Recept. 2000 May-Aug;9(3-4):137-59 [10899700.001]
  • [Cites] Biol Signals Recept. 2000 May-Aug;9(3-4):160-71 [10899701.001]
  • [Cites] J Biol Chem. 2000 Oct 6;275(40):31311-7 [10913150.001]
  • [Cites] FASEB J. 2000 Sep;14(12):1677-9 [10973915.001]
  • [Cites] Pharmacol Rev. 2001 Mar;53(1):135-59 [11171943.001]
  • [Cites] Ann N Y Acad Sci. 2001 Jun;939:200-15 [11462772.001]
  • [Cites] J Biol Chem. 2001 Nov 2;276(44):41279-87 [11533038.001]
  • [Cites] J Biol Chem. 1994 Nov 18;269(46):28531-4 [7961794.001]
  • [Cites] Toxicol Ind Health. 1993 Jan-Apr;9(1-2):197-214 [8093420.001]
  • [Cites] Free Radic Biol Med. 2000 Mar 15;28(6):904-11 [10802221.001]
  • [Cites] J Clin Endocrinol Metab. 2000 Jun;85(6):2189-96 [10852451.001]
  • [Cites] J Neurosurg. 2000 Jul;93(1 Suppl):77-84 [10879762.001]
  • [Cites] Endocrinology. 1979 Feb;104(2):295-301 [109277.001]
  • [Cites] J Pineal Res. 2000 Aug;29(1):34-9 [10949538.001]
  • [Cites] Int J Neurosci. 2000 Sep-Oct;104(1-4):63-73 [11011974.001]
  • [Cites] J Neurotrauma. 2000 Oct;17(10):915-25 [11063057.001]
  • [Cites] J Pineal Res. 2000 Nov;29(4):193-200 [11068941.001]
  • [Cites] Free Radic Biol Med. 2000 Dec1;29(11):1177-85 [11121726.001]
  • [Cites] Biochemistry (Mosc). 2001 Jan;66(1):19-26 [11240388.001]
  • [Cites] Neuroscience. 2001;103(1):203-18 [11311801.001]
  • [Cites] Clin Chem Lab Med. 2001 Apr;39(4):362-7 [11388663.001]
  • [Cites] Nat Rev Neurosci. 2001 Jul;2(7):502-11 [11433375.001]
  • [Cites] J Affect Disord. 2001 Aug;65(3):307-13 [11511411.001]
  • [Cites] Neurochem Res. 2001 Jun;26(6):739-64 [11519733.001]
  • [Cites] Neuro Endocrinol Lett. 2002 Apr;23 Suppl 1:79-83 [12019357.001]
  • [Cites] Curr Opin Neurol. 2002 Jun;15(3):355-60 [12045737.001]
  • [Cites] J Pineal Res. 2002 Aug;33(1):48-56 [12121485.001]
  • [Cites] J Pineal Res. 2004 Oct;37(3):198-206 [15357665.001]
  • [Cites] Curr Opin Cell Biol. 2004 Oct;16(5):558-64 [15363807.001]
  • [Cites] J Pineal Res. 2004 Nov;37(4):252-6 [15485551.001]
  • [Cites] Free Radic Biol Med. 2004 Dec 1;37(11):1790-801 [15528038.001]
  • [Cites] J Pineal Res. 2005 Jan;38(1):67-71 [15617539.001]
  • [Cites] J Neurosci Res. 2005 Mar 1;79(5):628-37 [15668909.001]
  • [Cites] J Pineal Res. 2005 Mar;38(2):107-15 [15683465.001]
  • [Cites] Sheng Li Xue Bao. 2005 Feb 25;57(1):7-12 [15719129.001]
  • [Cites] J Neurol Sci. 2002 Aug 15;200(1-2):33-41 [12127673.001]
  • [Cites] J Neurosci. 2002 Sep 1;22(17):7526-35 [12196576.001]
  • [Cites] J Pineal Res. 2002 Oct;33(3):186-7 [12220335.001]
  • [Cites] J Neurol Sci. 2002 Oct 15;202(1-2):13-23 [12220687.001]
  • [Cites] Pharmacol Res. 2002 Aug;46(2):133-9 [12220952.001]
  • [Cites] J Pineal Res. 2003 Mar;34(2):95-102 [12562500.001]
  • [Cites] Life Sci. 2003 Apr 4;72(20):2183-98 [12628439.001]
  • [Cites] J Neurosci. 2003 Nov 5;23(31):10107-15 [14602826.001]
  • [Cites] Surg Today. 2003;33(12):896-901 [14669079.001]
  • [Cites] Neurotox Res. 2003;5(6):375-83 [14715440.001]
  • [Cites] Biomed Pharmacother. 2004 Jan;58(1):39-46 [14739060.001]
  • [Cites] J Nutr. 2004 Mar;134(3):655-60 [14988463.001]
  • [Cites] J Pineal Res. 2004 Apr;36(3):171-6 [15009507.001]
  • [Cites] Chin Med J (Engl). 2004 Apr;117(4):571-5 [15109452.001]
  • [Cites] Pain. 2004 Jun;109(3):340-50 [15157695.001]
  • [Cites] Eur Spine J. 2004 Dec;13(8):724-32 [15232723.001]
  • [Cites] In Vivo. 2004 May-Jun;18(3):245-67 [15341181.001]
  • [Cites] Pigment Cell Res. 2004 Oct;17(5):454-60 [15357831.001]
  • [Cites] J Clin Endocrinol Metab. 2005 Feb;90(2):992-1000 [15562014.001]
  • [Cites] Trends Mol Med. 2004 Dec;10(12):580-3 [15567326.001]
  • [Cites] Spinal Cord. 2005 Feb;43(2):85-95 [15570322.001]
  • [Cites] J Pineal Res. 2005 Apr;38(3):198-208 [15725342.001]
  • [Cites] J Spinal Cord Med. 2005;28(1):55-9 [15832904.001]
  • [Cites] Spinal Cord. 2006 Feb;44(2):78-81 [16130027.001]
  • [Cites] J Pineal Res. 2005 Nov;39(4):400-8 [16207296.001]
  • [Cites] Surg Neurol. 2005 Oct;64(4):355-61 [16231427.001]
  • [Cites] Biochem Pharmacol. 2005 Dec 19;71(1-2):74-88 [16293234.001]
  • [Cites] J Neurosurg Spine. 2006 Feb;4(2):145-53 [16506482.001]
  • [Cites] J Immunol. 2006 Jun 1;176(11):6785-93 [16709838.001]
  • [Cites] J Pineal Res. 2006 Oct;41(3):279-83 [16948790.001]
  • [Cites] Indian J Med Sci. 2006 Dec;60(12):523-35 [17130668.001]
  • [Cites] J Neurochem. 2007 Feb;100(3):639-49 [17181549.001]
  • [Cites] Neuro Endocrinol Lett. 2006 Oct;27(5):601-8 [17186997.001]
  • [Cites] Int J Clin Pract. 2007 May;61(5):835-45 [17298593.001]
  • [Cites] Neurol Res. 2007 Sep;29(6):533-9 [17535569.001]
  • [Cites] J Pineal Res. 2007 Sep;43(2):140-53 [17645692.001]
  • (PMID = 21358973.001).
  • [ISSN] 1875-6190
  • [Journal-full-title] Current neuropharmacology
  • [ISO-abbreviation] Curr Neuropharmacol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United Arab Emirates
  • [Other-IDs] NLM/ PMC3001216
  • [Keywords] NOTNLM ; Melatonin / antioxidant / free radical. / inflammation / mitochondria / neurodegeneration
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6. Rosiak J, Michael Iuvone P, Zawilska JB: UV-A light regulation of arylalkylamine N-acetyltransferase activity in the chick pineal gland: role of cAMP and proteasomal proteolysis. J Pineal Res; 2005 Nov;39(4):419-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] UV-A light regulation of arylalkylamine N-acetyltransferase activity in the chick pineal gland: role of cAMP and proteasomal proteolysis.
  • Acute exposure of dark-adapted, cultured chick pineal glands to UV-A light significantly decreased the tissue cAMP concentration and the activity of arylalkylamine N-acetyltransferase (AANAT), the penultimate and key regulatory enzyme in the melatonin biosynthetic pathway.
  • The UV-A light-evoked decline in pineal AANAT activity was blocked by cAMP protagonists (forskolin and dibutyryl-cAMP) and by inhibitors of the proteasomal degradation pathway (MG-132, proteasome inhibitor I, and lactacystin).
  • These results indicate that the chick pineal gland is directly sensitive to UV-A light.
  • By analogy to white light, the suppressive action of UV-A radiation on AANAT activity in the chick pineal gland involves changes in the tissue cAMP level and enhanced proteasomal proteolysis.
  • [MeSH-major] Arylalkylamine N-Acetyltransferase / metabolism. Cyclic AMP / physiology. Pineal Gland / physiology. Pineal Gland / radiation effects. Proteasome Endopeptidase Complex / metabolism. Ultraviolet Rays

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  • (PMID = 16207298.001).
  • [ISSN] 0742-3098
  • [Journal-full-title] Journal of pineal research
  • [ISO-abbreviation] J. Pineal Res.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / R01 EY004864
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Leupeptins; 0 / Oligopeptides; 0 / benzyloxycarbonyl-isoleucyl-glutamyl(O-tert-butyl)-alanyl-leucinal; 133343-34-7 / lactacystin; 133407-82-6 / benzyloxycarbonylleucyl-leucyl-leucine aldehyde; 1F7A44V6OU / Colforsin; 63X7MBT2LQ / Bucladesine; E0399OZS9N / Cyclic AMP; EC 2.3.1.87 / Arylalkylamine N-Acetyltransferase; EC 3.4.25.1 / Proteasome Endopeptidase Complex; WYQ7N0BPYC / Acetylcysteine
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7. Kim JS, Bailey MJ, Ho AK, Møller M, Gaildrat P, Klein DC: Daily rhythm in pineal phosphodiesterase (PDE) activity reflects adrenergic/3',5'-cyclic adenosine 5'-monophosphate induction of the PDE4B2 variant. Endocrinology; 2007 Apr;148(4):1475-85
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  • [Title] Daily rhythm in pineal phosphodiesterase (PDE) activity reflects adrenergic/3',5'-cyclic adenosine 5'-monophosphate induction of the PDE4B2 variant.
  • The pineal gland is a photoneuroendocrine transducer that influences circadian and circannual dynamics of many physiological functions via the daily rhythm in melatonin production and release.
  • Melatonin synthesis is stimulated at night by a photoneural system through which pineal adenylate cyclase is adrenergically activated, resulting in an elevation of cAMP. cAMP enhances melatonin synthesis through actions on several elements of the biosynthetic pathway. cAMP degradation also appears to increase at night due to an increase in phosphodiesterase (PDE) activity, which peaks in the middle of the night.
  • The evidence that PDE4B2 plays a negative feedback role in adrenergic/cAMP signaling in the pineal gland provides the first proof that cAMP control of PDE4B2 is a physiologically relevant control mechanism in cAMP signaling.
  • [MeSH-major] 3',5'-Cyclic-AMP Phosphodiesterases / metabolism. Circadian Rhythm. Cyclic AMP / pharmacology. Norepinephrine / pharmacology. Pineal Gland / enzymology

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  • [CommentIn] Endocrinology. 2007 Apr;148(4):1473-4 [17369498.001]
  • (PMID = 17204557.001).
  • [ISSN] 0013-7227
  • [Journal-full-title] Endocrinology
  • [ISO-abbreviation] Endocrinology
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Isoenzymes; 0 / RNA, Messenger; E0399OZS9N / Cyclic AMP; EC 3.1.4.17 / 3',5'-Cyclic-AMP Phosphodiesterases; EC 3.1.4.17 / Cyclic Nucleotide Phosphodiesterases, Type 4; JL5DK93RCL / Melatonin; X4W3ENH1CV / Norepinephrine
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8. Migaud H, Taylor JF, Taranger GL, Davie A, Cerdá-Reverter JM, Carrillo M, Hansen T, Bromage NR: A comparative ex vivo and in vivo study of day and night perception in teleosts species using the melatonin rhythm. J Pineal Res; 2006 Aug;41(1):42-52
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  • First, a range of light intensities were tested ex vivo on pineal melatonin production in culture during the dark phase.
  • Results showed that sea bass pineal gland ex vivo are at least 10 times more sensitive to light than that of the salmon.
  • These highlighted species-specific light sensitivities of pineal melatonin production that are likely to be the result of adaptation to particular photic niches.
  • Light transmission results showed that a significantly higher percentage of light penetrates the sea bass pineal window relative to salmon, and confirmed that penetration is directly related to wavelength with higher penetration towards the red end of the visible spectrum.
  • The pineal gland in isolation thus appeared to have different sensitivities as the whole animal, suggesting that retinal and/or deep brain photoreception may contribute, in vivo, to the control of melatonin production.

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  • (PMID = 16842540.001).
  • [ISSN] 0742-3098
  • [Journal-full-title] Journal of pineal research
  • [ISO-abbreviation] J. Pineal Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] JL5DK93RCL / Melatonin
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9. Peraud A, Goetz C, Siefert A, Tonn JC, Kreth FW: Interstitial iodine-125 radiosurgery alone or in combination with microsurgery for pediatric patients with eloquently located low-grade glioma: a pilot study. Childs Nerv Syst; 2007 Jan;23(1):39-46
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  • Radical surgical resection is the first-line treatment for large hemispheric tumors, whereas interstitial iodine-125 radiosurgery (IRS) might be an attractive treatment concept for selected patients with small (tumor diameter in the range of 4 cm) and circumscribed tumors in any location of the brain.
  • Therefore, the therapeutic impact and the risk of IRS alone or in combination with microsurgery (in case of larger tumor volumes) were prospectively examined.
  • Temporary iodine-125 seeds were used exclusively (tumor dose calculated to the boundary, 54 Gy; dose rate, 10 cGy/h).
  • Tumor location was hypothalamic/suprasellar in four, lobar in three, deep (thalamus and pineal gland) in two, and within the brain stem in two children.
  • [MeSH-major] Brain Neoplasms / surgery. Glioma / surgery. Iodine Radioisotopes / therapeutic use. Microsurgery. Radiopharmaceuticals / therapeutic use. Radiosurgery

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  • [Cites] Curr Opin Oncol. 2000 May;12(3):194-8 [10841190.001]
  • [Cites] Eur Radiol. 2001;11(12):2638-40 [11734972.001]
  • [Cites] Pediatr Neurosurg. 2000 Mar;32(3):132-6 [10867559.001]
  • [Cites] J Neurosurg. 1985 Jun;62(6):811-5 [3998829.001]
  • [Cites] Neurosurgery. 1994 Aug;35(2):342-3 [7969850.001]
  • [Cites] Neurosurgery. 2002 May;50(5):966-75; discussion 975-7 [11950399.001]
  • [Cites] J Neurosurg. 1995 Apr;82(4):536-47 [7897512.001]
  • [Cites] J Child Neurol. 1999 Jun;14(6):352-6 [10385841.001]
  • [Cites] Cancer. 2006 Mar 15;106(6):1372-81 [16470609.001]
  • [Cites] J Neurosurg. 1995 Oct;83(4):583-9 [7674005.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2001 Nov 1;51(3):704-10 [11597812.001]
  • [Cites] Radiother Oncol. 1997 Jun;43(3):253-60 [9215784.001]
  • [Cites] Acta Neurochir (Wien). 2001;143(6):539-45; discussion 545-6 [11534670.001]
  • [Cites] J Neurosurg. 1995 Mar;82(3):418-29 [7861220.001]
  • (PMID = 16972111.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 0 / Radiopharmaceuticals
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10. Karakaş A, Kaya A, Gündüz B: The effect of pinealectomy, melatonin and leptin hormones on ovarian follicular development in female Syrian hamsters (Mesocricetus auratus). Acta Biol Hung; 2010 Dec;61(4):380-90
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  • The results of the present study indicate that the removal of the pineal gland and leptin hormone administration are playing a stimulatory while melatonin hormone administration is playing an inhibitory role on the follicular development in female Syrian hamsters.
  • [MeSH-major] Leptin / metabolism. Melatonin / metabolism. Ovary / drug effects. Ovary / growth & development. Pineal Gland / physiology. Pineal Gland / surgery

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  • (PMID = 21112830.001).
  • [ISSN] 0236-5383
  • [Journal-full-title] Acta biologica Hungarica
  • [ISO-abbreviation] Acta. Biol. Hung.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Leptin; JL5DK93RCL / Melatonin
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11. Borges-Silva Cd, Takada J, Alonso-Vale MI, Peres SB, Fonseca-Alaniz MH, Andreotti S, Cipolla-Neto J, Pithon-Curi TC, Lima FB: Pinealectomy reduces hepatic and muscular glycogen content and attenuates aerobic power adaptability in trained rats. J Pineal Res; 2007 Aug;43(1):96-103
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  • The current study emphasizes the crucial role of the pineal gland on the effects of chronic training in different tissues focusing on carbohydrate metabolism.
  • In conclusion, these data show that the pineal gland integrity is necessary for the homeostatic control of energy metabolism among adipose, muscle and hepatic tissues.
  • Therefore, the pineal gland must be considered an influential participant in the complex adaptation to exercise and is involved in the improvement of endurance capacity.
  • [MeSH-major] Glycogen / metabolism. Liver / metabolism. Muscles / metabolism. Oxygen Consumption / physiology. Physical Conditioning, Animal. Pineal Gland / surgery

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  • (PMID = 17614841.001).
  • [ISSN] 0742-3098
  • [Journal-full-title] Journal of pineal research
  • [ISO-abbreviation] J. Pineal Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 9005-79-2 / Glycogen
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12. Fischer TW, Slominski A, Tobin DJ, Paus R: Melatonin and the hair follicle. J Pineal Res; 2008 Jan;44(1):1-15
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  • Melatonin, the chief secretory product of the pineal gland, has long been known to modulate hair growth, pigmentation and/or molting in many species, presumably as a key neuroendocrine regulator that couples coat phenotype and function to photoperiod-dependent environmental and reproductive changes.
  • Moreover, HF melatonin production is enhanced by catecholamines (as it classically occurs in the pineal gland).

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  • (PMID = 18078443.001).
  • [ISSN] 0742-3098
  • [Journal-full-title] Journal of pineal research
  • [ISO-abbreviation] J. Pineal Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Receptors, Androgen; 0 / Receptors, Estrogen; 0 / Receptors, Melatonin; JL5DK93RCL / Melatonin
  • [Number-of-references] 197
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13. Peres MF: Melatonin, the pineal gland and their implications for headache disorders. Cephalalgia; 2005 Jun;25(6):403-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melatonin, the pineal gland and their implications for headache disorders.
  • [MeSH-major] Headache Disorders / drug therapy. Headache Disorders / physiopathology. Melatonin / metabolism. Melatonin / therapeutic use. Pineal Gland / metabolism

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  • (PMID = 15910564.001).
  • [ISSN] 0333-1024
  • [Journal-full-title] Cephalalgia : an international journal of headache
  • [ISO-abbreviation] Cephalalgia
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] JL5DK93RCL / Melatonin
  • [Number-of-references] 77
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14. Sinitskaya N, Salingre A, Klosen P, Revel FG, Pévet P, Simonneaux V: Differential expression of activator protein-1 proteins in the pineal gland of Syrian hamster and rat may explain species diversity in arylalkylamine N-acetyltransferase gene expression. Endocrinology; 2006 Nov;147(11):5052-60
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  • [Title] Differential expression of activator protein-1 proteins in the pineal gland of Syrian hamster and rat may explain species diversity in arylalkylamine N-acetyltransferase gene expression.
  • In particular, de novo synthesis of stimulatory transcription factors is required for Aa-nat transcription in the Syrian hamster but not in the rat pineal gland.
  • Therefore, composition and timing of the pineal activator protein-1 complexes differ between rat and Syrian hamster and may be an activator (Syrian hamster) or an inhibitor (rat) of Aa-nat transcription.
  • [MeSH-major] Arylamine N-Acetyltransferase / genetics. Cyclic AMP Response Element-Binding Protein / analysis. Pineal Gland / chemistry. Proto-Oncogene Proteins c-fos / analysis. Proto-Oncogene Proteins c-jun / analysis

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  • (PMID = 16887909.001).
  • [ISSN] 0013-7227
  • [Journal-full-title] Endocrinology
  • [ISO-abbreviation] Endocrinology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclic AMP Response Element-Binding Protein; 0 / Proto-Oncogene Proteins c-fos; 0 / Proto-Oncogene Proteins c-jun; 0 / RNA, Messenger; 0 / Receptors, Adrenergic; 98600C0908 / Cycloheximide; EC 2.3.1.5 / Arylamine N-Acetyltransferase
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15. Kaur C, Sivakumar V, Ling EA: Expression of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) GluR2/3 receptors in the developing rat pineal gland. J Pineal Res; 2005 Oct;39(3):294-301
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  • [Title] Expression of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) GluR2/3 receptors in the developing rat pineal gland.
  • The expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) type glutamate (GluR2/3) receptors and N-methyl-D-aspartate receptor subtype 1 (NMDAR1) was carried out by immunohistochemistry, double immunofluorescence and real-time RT-PCR analysis in the pineal glands of 1-day to 6-wk-old rats in the present study.
  • GluR2/3 immunopositive cells were distributed throughout the pineal gland and showed branching processes in all age groups.
  • A constitutive mRNA expression of NMDAR1, GluR2 and GluR3 was detected in the pineal glands of various ages and showed no significant difference between the age groups studied.
  • The expression of these receptors on the glial cells suggests that they may be involved in the development and growth of the pineal gland in the early postnatal period (1 day to 3 wk) and subsequently in the regulation of melatonin synthesis.
  • [MeSH-major] Pineal Gland / growth & development. Pineal Gland / metabolism. Receptors, AMPA / biosynthesis. Receptors, N-Methyl-D-Aspartate / biosynthesis

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  • (PMID = 16150111.001).
  • [ISSN] 0742-3098
  • [Journal-full-title] Journal of pineal research
  • [ISO-abbreviation] J. Pineal Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Receptors, AMPA; 0 / Receptors, N-Methyl-D-Aspartate; 0 / glutamate receptor ionotropic, AMPA 2; 0 / glutamate receptor ionotropic, AMPA 3
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16. Wan L, Almers W, Chen W: Two ribeye genes in teleosts: the role of Ribeye in ribbon formation and bipolar cell development. J Neurosci; 2005 Jan 26;25(4):941-9
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  • Whole-mount in situ hybridization revealed that ribeye a is expressed in tissues containing synaptic ribbons, including the pineal gland, inner ear, and retina.
  • Ribeye b is absent in the pineal gland.

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  • (PMID = 15673675.001).
  • [ISSN] 1529-2401
  • [Journal-full-title] The Journal of neuroscience : the official journal of the Society for Neuroscience
  • [ISO-abbreviation] J. Neurosci.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / R01 EY014171; United States / NIDDK NIH HHS / DK / DK44239; United States / NEI NIH HHS / EY / EY14171; United States / NIMH NIH HHS / MH / MH60600
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Eye Proteins; 0 / Oligodeoxyribonucleotides, Antisense
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17. Mouratova T: Trilateral retinoblastoma: a literature review, 1971-2004. Bull Soc Belge Ophtalmol; 2005;(297):25-35
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  • This study analyzes modern views on the history, variants, age at diagnosis of trilateral retinoblastoma, median time from retinoblastoma to trilateral retinoblastoma, the largest size and percentage of trilateral retinoblastoma among retinoblastoma cases, functions of pineal gland, genetics, ocular and intracranial histology, diagnosis, treatment, therapy results, survival rates and frequency of screening of trilateral retinoblastoma.
  • [MeSH-major] Retinal Neoplasms / diagnosis. Retinal Neoplasms / epidemiology. Retinoblastoma / diagnosis. Retinoblastoma / epidemiology
  • [MeSH-minor] Age Distribution. Age of Onset. Animals. Child. Child, Preschool. Disease Progression. Female. Humans. Incidence. Infant. Male. Mass Screening / methods. Pineal Gland / physiopathology. Sex Distribution. Survival Rate

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  • (PMID = 16281731.001).
  • [ISSN] 0081-0746
  • [Journal-full-title] Bulletin de la Société belge d'ophtalmologie
  • [ISO-abbreviation] Bull Soc Belge Ophtalmol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 92
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18. Jovanova-Nesic K, Eric-Jovicic M, Spector NH: MAgnetic stimulation of the brain increase Na+, K+-ATPase activity decreased by injection of AlCl3 into nucleus basalis magnocellularis of rats. Int J Neurosci; 2006 Jun;116(6):681-95
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  • This article reports here on the influence of the static magnetic fields (MFs), locally applied to the brain area, on Na, K-ATPase activity in the rat with lesioned nucleus basalis magnocellularis (NBM) by intracerebral injection of 5 microl, 1% AlCl3 into the nucleus.
  • Two AKMA micromagnets (M) flux density of 60 miliTesla, 5 mm in diameter, were bilaterally implanted with "N" polarity facing down to the cranial bones in the vicinity of the pineal gland (PG), immediately after the lesioning of NBM, during the same operation procedure.

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  • (PMID = 16753895.001).
  • [ISSN] 0020-7454
  • [Journal-full-title] The International journal of neuroscience
  • [ISO-abbreviation] Int. J. Neurosci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aluminum Compounds; 0 / Chlorides; 3CYT62D3GA / aluminum chloride; EC 3.6.3.9 / Sodium-Potassium-Exchanging ATPase
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19. Bushell WC: From molecular biology to anti-aging cognitive-behavioral practices: the pioneering research of Walter Pierpaoli on the pineal and bone marrow foreshadows the contemporary revolution in stem cell and regenerative biology. Ann N Y Acad Sci; 2005 Dec;1057:28-49
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  • [Title] From molecular biology to anti-aging cognitive-behavioral practices: the pioneering research of Walter Pierpaoli on the pineal and bone marrow foreshadows the contemporary revolution in stem cell and regenerative biology.
  • More than a quarter of a century ago, Walter Pierpaoli initiated a series of extraordinary studies that demonstrated in experimental animals the potential for dramatic regeneration associated with changes in the pineal gland and bone marrow.
  • [MeSH-minor] Adult. Animals. Bone Marrow Cells / metabolism. Diet. Exercise. Humans. Meditation. Melatonin / metabolism. Mice. Neoplasms / metabolism. Pineal Gland. Stem Cells. Stress, Physiological

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  • (PMID = 16399886.001).
  • [ISSN] 0077-8923
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] JL5DK93RCL / Melatonin
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20. van der Spuy J, Munro PM, Luthert PJ, Preising MN, Bek T, Heegaard S, Cheetham ME: Predominant rod photoreceptor degeneration in Leber congenital amaurosis. Mol Vis; 2005;11:542-53
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  • The AIPL1 protein is expressed in the pineal gland and retinal photoreceptors.

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  • (PMID = 16052170.001).
  • [ISSN] 1090-0535
  • [Journal-full-title] Molecular vision
  • [ISO-abbreviation] Mol. Vis.
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AIPL1 protein, human; 0 / Carrier Proteins; 0 / Eye Proteins; 0 / Glial Fibrillary Acidic Protein; 0 / Homeodomain Proteins; 0 / Receptors, Cell Surface; 0 / Trans-Activators; 0 / cone rod homeobox protein; 0 / guanylate cyclase 1; 9009-81-8 / Rhodopsin; EC 3.1.1.64 / retinoid isomerohydrolase; EC 4.6.1.2 / Guanylate Cyclase; EC 5.2.- / cis-trans-Isomerases
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21. Weinert D, Freyberg S, Touitou Y, Djeridane Y, Waterhouse JM: The phasing of circadian rhythms in mice kept under normal or short photoperiods. Physiol Behav; 2005 Apr 13;84(5):791-8
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  • The daily profiles of food intake, liver glycogen and melatonin in the serum and the pineal gland were estimated as transverse studies under L/D=12:12 h and L/D=6:18 h.
  • [MeSH-minor] Animals. Eating. Female. Liver / metabolism. Liver Glycogen / metabolism. Melatonin / metabolism. Mice. Mice, Inbred ICR. Motor Activity / physiology. Pineal Gland / metabolism

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  • (PMID = 15885257.001).
  • [ISSN] 0031-9384
  • [Journal-full-title] Physiology & behavior
  • [ISO-abbreviation] Physiol. Behav.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Liver Glycogen; JL5DK93RCL / Melatonin
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22. Sahach VF, Rudyk OV, Vavilova HL, Kotsiuruba AV, Tkachenko IuP: [Melatonin recovers ischemic tolerance and decreases the sensitivity of mitochondrial permeability transition pore opening in the heart of aging rats]. Fiziol Zh; 2006;52(3):3-14
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  • The effect of the hormone of pineal gland melatonin on the ischemic tolerance and the sensitivity of mitochondrial permeability transition pore opening in old rat heart were studied.

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  • (PMID = 16909751.001).
  • [Journal-full-title] Fiziolohichnyĭ zhurnal (Kiev, Ukraine : 1994)
  • [ISO-abbreviation] Fiziol Zh
  • [Language] ukr
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Ukraine
  • [Chemical-registry-number] 0 / Bax protein, rat; 0 / Free Radicals; 0 / Mitochondrial Membrane Transport Proteins; 0 / bcl-2-Associated X Protein; 0 / mitochondrial permeability transition pore; EC 1.14.13.39 / Nitric Oxide Synthase; JL5DK93RCL / Melatonin
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23. Møller M, Lund-Andersen C, Rovsing L, Sparre T, Bache N, Roepstorff P, Vorum H: Proteomics of the photoneuroendocrine circadian system of the brain. Mass Spectrom Rev; 2010 Mar-Apr;29(2):313-25
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  • The photoneuroendocrine circadian system of the brain consists of (a) specialized photoreceptors in the retina, (b) a circadian generator located in the forebrain that contains "clock genes," (c) specialized nuclei in the forebrain involved in neuroendocrine secretion, and (d) the pineal gland.
  • In this survey, the anatomy and function of the circadian-generating system in mammals is described, and recent proteomic studies that investigate day/night changes in the retina, SCN, and pineal gland are reviewed.

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  • [Copyright] Copyright 2009 Wiley Periodicals, Inc.
  • (PMID = 19437489.001).
  • [ISSN] 1098-2787
  • [Journal-full-title] Mass spectrometry reviews
  • [ISO-abbreviation] Mass Spectrom Rev
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proteome
  • [Number-of-references] 59
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24. Huang TS, Ruoff P, Fjelldal PG: Effect of continuous light on daily levels of plasma melatonin and cortisol and expression of clock genes in pineal gland, brain, and liver in atlantic salmon postsmolts. Chronobiol Int; 2010 Oct;27(9-10):1715-34
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  • [Title] Effect of continuous light on daily levels of plasma melatonin and cortisol and expression of clock genes in pineal gland, brain, and liver in atlantic salmon postsmolts.
  • The aim of the present study was to evaluate the daily expression of clock (Per1-like, Cry2, and Clock), the nuclear transcription factor (peroxisome proliferator-activated receptor, PPAR; CCAAT/enhancer binding protein, C/EBP), and the endoplasmic reticulum (ER) stress (protein disulfide isomerase associated 3, PDIA3) genes in the pineal gland, brain, and liver of Atlantic salmon postsmolts reared under 12-h light:12-h dark (LD) regimes or under continuous light (LL) for 6 wks following transfer to seawater.
  • Similar variations were noted in the liver c/ebpα, pineal c/ebpδ, and pdia3 mRNAs.
  • Under LL, the clock and nuclear transcription factor mRNAs did not show any daily variation in the studied organs, with the exception of pineal pdia3.
  • Furthermore, LL had the opposite effect on the levels of melatonin and cortisol, as observed by the increase in pineal Clock, Per2, pparα, and c/ebpα and c/ebpδ mRNAs and decrease in liver Clock, Per2, and pparα mRNAs compared to those under LD.
  • The present findings show that the expression of clock genes is affected by the light across organs and that there is a relation between PPAR, C/EBP, and clock mRNAs; however, the functional role of the individual nuclear transcription factors related to this observation remains to be established in the pineal gland and liver. (Author correspondence: Tihu@nifes.no ).
  • [MeSH-minor] Animals. Brain / physiology. Cryptochromes / genetics. DNA Primers. Growth / radiation effects. Liver / physiology. Molting / physiology. Pineal Gland / physiology. Polymerase Chain Reaction. RNA, Messenger / genetics. Seasons

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  • (PMID = 20969519.001).
  • [ISSN] 1525-6073
  • [Journal-full-title] Chronobiology international
  • [ISO-abbreviation] Chronobiol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cryptochromes; 0 / DNA Primers; 0 / Period Circadian Proteins; 0 / RNA, Messenger; EC 2.3.1.48 / CLOCK Proteins; JL5DK93RCL / Melatonin; WI4X0X7BPJ / Hydrocortisone
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25. Karaganis SP, Kumar V, Beremand PD, Bailey MJ, Thomas TL, Cassone VM: Circadian genomics of the chick pineal gland in vitro. BMC Genomics; 2008 May 03;9:206
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  • [Title] Circadian genomics of the chick pineal gland in vitro.
  • These properties make the in vitro pineal a particularly useful model for exploring circadian control of gene transcription in a pacemaker tissue, as well as regulation of the transcriptome by primary inputs to the clock (both photic and noradrenergic).
  • CONCLUSION: Our combined approach of utilizing a temporal, photic and pharmacological microarray experiment allowed us to identify novel genes linking clock input to clock function within the pineal.
  • We identified approximately 30 rhythmic, light-responsive, NE-insensitive genes with no previously known clock function, which may play a role in circadian regulation of the pineal.
  • Further, we hypothesize that the pineal circadian transcriptome is reduced but functionally conserved in vitro, and supports an endogenous role for the pineal in regulating local rhythms in metabolism, immune function, and other conserved pathways.

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  • [Cites] Science. 1999 Oct 22;286(5440):766-8 [10531060.001]
  • [Cites] J Biol Rhythms. 2006 Oct;21(5):350-61 [16998155.001]
  • [Cites] J Neurochem. 2000 Jun;74(6):2315-21 [10820191.001]
  • [Cites] Microsc Res Tech. 2001 Apr 1;53(1):43-7 [11279669.001]
  • [Cites] Neurosci Lett. 2001 Nov 2;313(1-2):13-6 [11684328.001]
  • [Cites] J Biol Chem. 2002 Apr 19;277(16):14048-52 [11854264.001]
  • [Cites] Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9562-7 [12089325.001]
  • [Cites] Cell Tissue Res. 2002 Jul;309(1):35-45 [12111535.001]
  • [Cites] Cell Tissue Res. 2002 Jul;309(1):127-37 [12111543.001]
  • [Cites] J Neuroendocrinol. 2003 Oct;15(10):991-1002 [12969245.001]
  • [Cites] Mol Endocrinol. 2003 Oct;17(10):2084-95 [12881511.001]
  • [Cites] Science. 1974 Jun 28;184(4144):1341-8 [4151465.001]
  • [Cites] Endocrinology. 1975 Feb;96(2):543-6 [1078656.001]
  • [Cites] Science. 1979 Feb 16;203(4381):656-8 [569904.001]
  • [Cites] Nature. 1979 Nov 1;282(5734):94-6 [503196.001]
  • [Cites] Proc Natl Acad Sci U S A. 1980 Apr;77(4):2319-22 [6929552.001]
  • [Cites] Brain Res. 1983 Aug 8;272(2):311-7 [6616205.001]
  • [Cites] J Exp Zool. 1984 Dec;232(3):539-49 [6394696.001]
  • [Cites] Ciba Found Symp. 1985;117:38-56 [3015512.001]
  • [Cites] Brain Res. 1986 Oct 8;384(2):334-41 [3779384.001]
  • [Cites] Gen Comp Endocrinol. 1987 Dec;68(3):343-56 [3436512.001]
  • [Cites] Brain Res. 1988 Jan 12;438(1-2):199-215 [3345427.001]
  • [Cites] Brain Res. 1988 Jun 21;453(1-2):51-62 [2841014.001]
  • [Cites] Brain Res. 1988 Jun 21;453(1-2):63-71 [3401779.001]
  • [Cites] J Comp Physiol A. 1990 Jul;167(2):187-92 [1976805.001]
  • [Cites] J Biol Rhythms. 1991 Summer;6(2):137-47 [1773087.001]
  • [Cites] J Biol Rhythms. 1992 Winter;7(4):301-11 [1337482.001]
  • [Cites] Brain Res. 1994 Jul 18;651(1-2):209-14 [7922568.001]
  • [Cites] Experientia. 1995 Sep 29;51(9-10):970-5 [7556580.001]
  • [Cites] Proc Natl Acad Sci U S A. 1997 Jan 7;94(1):304-9 [8990204.001]
  • [Cites] Braz J Med Biol Res. 1997 Mar;30(3):305-13 [9246228.001]
  • [Cites] Science. 1998 Feb 27;279(5355):1358-60 [9478897.001]
  • [Cites] Chronobiol Int. 1998 Sep;15(5):457-73 [9787936.001]
  • [Cites] Cell. 1999 Jan 22;96(2):271-90 [9988221.001]
  • [Cites] Reprod Nutr Dev. 1999 May-Jun;39(3):325-34 [10420435.001]
  • [Cites] J Biol Chem. 2004 Dec 10;279(50):52247-54 [15448147.001]
  • [Cites] Nat Rev Genet. 2005 Jul;6(7):544-56 [15951747.001]
  • [Cites] Science. 2000 May 12;288(5468):1013-9 [10807566.001]
  • (PMID = 18454867.001).
  • [ISSN] 1471-2164
  • [Journal-full-title] BMC genomics
  • [ISO-abbreviation] BMC Genomics
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / P01-NS35846
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Messenger; JL5DK93RCL / Melatonin; X4W3ENH1CV / Norepinephrine
  • [Other-IDs] NLM/ PMC2405806
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26. Brivio F, Fumagalli L, Fumagalli G, Pescia S, Brivio R, Di Fede G, Rovelli F, Lissoni P: Synchronization of cortisol circadian rhythm by the pineal hormone melatonin in untreatable metastatic solid tumor patients and its possible prognostic significance on tumor progression. In Vivo; 2010 Mar-Apr;24(2):239-41
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  • [Title] Synchronization of cortisol circadian rhythm by the pineal hormone melatonin in untreatable metastatic solid tumor patients and its possible prognostic significance on tumor progression.
  • Finally, cancer progression has been proven to be associated with alterations in the pineal gland, which plays a fundamental role in the control of circadian biological rhythms.
  • On this basis, a study was planned to evaluate the effects of a chronic treatment with the pineal hormone melatonin (MLT) in advanced cancer patients with altered cortisol circadian rhythm.
  • [MeSH-major] Circadian Rhythm / physiology. Hydrocortisone / blood. Melatonin / administration & dosage. Neoplasms
  • [MeSH-minor] Aged. Antioxidants / administration & dosage. Anxiety / drug therapy. Asthenia / drug therapy. Disease Progression. Female. Humans. Male. Middle Aged. Pineal Gland / drug effects. Pineal Gland / metabolism. Predictive Value of Tests. Prognosis

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  • (PMID = 20364003.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antioxidants; JL5DK93RCL / Melatonin; WI4X0X7BPJ / Hydrocortisone
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27. Pavese N, Moore RY, Scherfler C, Khan NL, Hotton G, Quinn NP, Bhatia KP, Wood NW, Brooks DJ, Lees AJ, Piccini P: In vivo assessment of brain monoamine systems in parkin gene carriers: a PET study. Exp Neurol; 2010 Mar;222(1):120-4
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  • The same structures showed reduced uptake in IPD patients, who additionally had significant reductions in hypothalamus, ventral anterior thalamus, and pineal gland.

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  • [Copyright] Copyright 2009 Elsevier Inc. All rights reserved.
  • [CommentIn] Exp Neurol. 2010 Sep;225(1):48-50 [20450912.001]
  • (PMID = 20043906.001).
  • [ISSN] 1090-2430
  • [Journal-full-title] Experimental neurology
  • [ISO-abbreviation] Exp. Neurol.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / MC/ U120036861
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biogenic Monoamines; 0Z5B2CJX4D / Fluorodeoxyglucose F18; EC 2.3.2.27 / Ubiquitin-Protein Ligases; EC 2.3.2.27 / parkin protein; EC 2.7.- / Protein Kinases; EC 2.7.11.1 / PTEN-induced putative kinase
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28. Naugler C, Xu Z: Pancreatic adenocarcinoma metastatic to the pineal gland. J Clin Neurosci; 2008 Nov;15(11):1284-6
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  • [Title] Pancreatic adenocarcinoma metastatic to the pineal gland.
  • Metastases to the pineal gland are rare and reported cases have consisted primarily of gastrointestinal and lung primary malignancies.
  • Here we present the case of a 66-year-old female with autosomal dominant polycystic kidney and liver disease who was found at autopsy to have an unrecognized infiltrating ductal adenocarcinoma of the pancreas with metastases to the liver, lungs and pineal gland.
  • As far as we are aware, this is the first report of a metastasis of infiltrating ductal adenocarcinoma of the pancreas to the pineal gland.
  • [MeSH-major] Adenocarcinoma / pathology. Brain Neoplasms / secondary. Pancreatic Neoplasms / pathology. Pineal Gland. Pinealoma / secondary

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  • (PMID = 18829324.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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29. Herwig A, Revel F, Saboureau M, Pévet P, Steinlechner S: Daily torpor alters multiple gene expression in the suprachiasmatic nucleus and pineal gland of the Djungarian hamster (Phodopus sungorus). Chronobiol Int; 2006;23(1-2):269-76
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Daily torpor alters multiple gene expression in the suprachiasmatic nucleus and pineal gland of the Djungarian hamster (Phodopus sungorus).
  • To reveal changes in the clockwork during torpor, we compared clock gene and neuropeptide expression by in situ hybridization in the suprachiasmatic nucleus (SCN) and pineal gland of normothermic and torpid Djungarian hamsters (Phodopus sungorus).
  • In the pineal gland, an important clock output, Aanat expression, peaked between ZT16 and ZT22 in normothermic animals.
  • Furthermore, the rhythmic gene expression in a peripheral oscillator, the pineal gland, is also affected.
  • [MeSH-major] Adaptation, Physiological. Gene Expression Regulation. Pineal Gland / metabolism. Suprachiasmatic Nucleus / metabolism

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  • (PMID = 16687300.001).
  • [ISSN] 0742-0528
  • [Journal-full-title] Chronobiology international
  • [ISO-abbreviation] Chronobiol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ARNTL Transcription Factors; 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Neuropeptides; EC 2.3.1.87 / Arylalkylamine N-Acetyltransferase
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30. Salingre A, Klosen P, Pévet P, Simonneaux V: Daytime gating in the Syrian hamster pineal gland. J Neuroendocrinol; 2009 Sep;21(9):760-9
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  • [Title] Daytime gating in the Syrian hamster pineal gland.
  • Taken together, our results indicate that the diurnal gating of pineal activity in the Syrian hamster is not caused by the repressor ICER and that it may occur at the level of noradrenergic receptor signalling.
  • [MeSH-major] Circadian Rhythm / genetics. Mesocricetus / genetics. Mesocricetus / physiology. Pineal Gland / physiology

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  • (PMID = 19549096.001).
  • [ISSN] 1365-2826
  • [Journal-full-title] Journal of neuroendocrinology
  • [ISO-abbreviation] J. Neuroendocrinol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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31. Peschke E: Doctor medicinae honoris causa of the Medical Faculty of the Martin Luther University of Halle-Wittenberg for the anatomist and researcher of the pineal gland Professor Dr. Lutz Vollrath from Mainz. Ann Anat; 2008;190(3):199-207
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  • [Title] Doctor medicinae honoris causa of the Medical Faculty of the Martin Luther University of Halle-Wittenberg for the anatomist and researcher of the pineal gland Professor Dr. Lutz Vollrath from Mainz.
  • [MeSH-major] Anatomy / history. Pineal Gland / anatomy & histology

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  • (PMID = 18668721.001).
  • [ISSN] 0940-9602
  • [Journal-full-title] Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft
  • [ISO-abbreviation] Ann. Anat.
  • [Language] eng
  • [Publication-type] Biography; Historical Article; Journal Article
  • [Publication-country] Germany
  • [Personal-name-as-subject] Vollrath L
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32. Shah R, Medina-Martinez O, Chu LF, Samaco RC, Jamrich M: Expression of FoxP2 during zebrafish development and in the adult brain. Int J Dev Biol; 2006;50(4):435-8
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  • However, in contrast to emx1, FoxP2 is not expressed in the pineal gland or in the pronephric duct.
  • The developing optic tectum becomes the major area of FoxP2 expression.

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  • (PMID = 16525940.001).
  • [ISSN] 0214-6282
  • [Journal-full-title] The International journal of developmental biology
  • [ISO-abbreviation] Int. J. Dev. Biol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ BQ617568/ BQ783717
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Forkhead Transcription Factors; 0 / FoxP2 protein, zebrafish; 0 / RNA, Messenger; 0 / Zebrafish Proteins
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33. Couto-Moraes R, Palermo-Neto J, Markus RP: The immune-pineal axis: stress as a modulator of pineal gland function. Ann N Y Acad Sci; 2009 Feb;1153:193-202
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  • [Title] The immune-pineal axis: stress as a modulator of pineal gland function.
  • The environmental light detected by the retina adjusts the central clock in the suprachiasmatic nuclei, which innervate the pineal gland through a polysynaptic pathway.
  • During the night, this gland produces and releases the nocturnal hormone melatonin, which circulates throughout the whole body and adjusts several bodily functions according to the existence and duration of darkness.
  • We have previously shown that during the time frame of an inflammatory response, pro-inflammatory cytokines, such as tumor necrosis factor-alpha, inhibit while anti-inflammatory mediators, such as glucocorticoids, enhance the synthesis of melatonin, interfering in the daily adjustment of the light/dark cycle.
  • Taking into account the data obtained with models of inflammation and stress, we reinforce the hypothesis that the activity of the pineal gland is modulated by the state of the immune system and the HPA axis, implicating the darkness hormone melatonin as a modulator of defense responses.
  • [MeSH-major] Immune System / physiopathology. Pineal Gland / immunology. Pineal Gland / physiopathology. Stress, Psychological / physiopathology

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  • (PMID = 19236342.001).
  • [ISSN] 1749-6632
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Inflammation Mediators; JL5DK93RCL / Melatonin; W980KJ009P / Corticosterone
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34. Dagnino-Subiabre A, Zepeda-Carreño R, Díaz-Véliz G, Mora S, Aboitiz F: Chronic stress induces upregulation of brain-derived neurotrophic factor (BDNF) mRNA and integrin alpha5 expression in the rat pineal gland. Brain Res; 2006 May 1;1086(1):27-34
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  • [Title] Chronic stress induces upregulation of brain-derived neurotrophic factor (BDNF) mRNA and integrin alpha5 expression in the rat pineal gland.
  • Moreover, stress induces deleterious actions on the epithalamic pineal organ, a gland involved in a wide range of physiological functions.
  • The aim of this study was to investigate whether the stress effects on the pineal gland are related with changes in the expression of neurotrophic factors and cell adhesion molecules.
  • Using reverse transcription-polymerase chain reaction (RT-PCR) and Western blot, we analyzed the effect of chronic immobilization stress on the BDNF mRNA and integrin alpha5 expression in the rat pineal gland.
  • We found that BDNF is produced in situ in the pineal gland.
  • Chronic immobilization stress induced upregulation of BDNF mRNA and integrin alpha5 expression in the rat pineal gland but did not produce changes in beta-actin mRNA or in GAPDH expression.
  • Furthermore, this study proposes that the pineal gland may be a target of glucocorticoid damage during stress.
  • [MeSH-major] Brain-Derived Neurotrophic Factor / metabolism. Gene Expression / physiology. Integrin alpha5 / metabolism. Pineal Gland / metabolism. Stress, Psychological / physiopathology. Up-Regulation / physiology

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  • (PMID = 16626638.001).
  • [ISSN] 0006-8993
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Brain-Derived Neurotrophic Factor; 0 / Integrin alpha5; 0 / RNA, Messenger
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35. Foà A, Brandstätter R, Bertolucci C: The circadian system of ruin lizards: a seasonally changing neuroendocrine loop? Chronobiol Int; 2006;23(1-2):317-27
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  • Previous studies have shown that the amplitude of daily melatonin production in cultured ruin lizard pineal organs explanted in the summer is significantly higher than that from organs explanted in the winter.
  • To test whether seasonal photoperiodic changes are decoded autonomously by the pineal gland, pineals explanted in summer were cultured in vitro and exposed to changes between winter and summer photoperiods.
  • The discrepancy between the present in vitro results and those from lizards exposed to winter or summer photoperiods before pineal explantation supports the view that circadian information entering the pineal gland via its innervation is involved in determining seasonal changes of melatonin production in ruin lizards.
  • We further examined whether a central component of the circadian system of ruin lizards, specifically the retinae of the lateral eyes, expresses similar seasonal changes in function as does the pineal gland.
  • [MeSH-major] Circadian Rhythm. Pineal Gland / anatomy & histology

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  • (PMID = 16687305.001).
  • [ISSN] 0742-0528
  • [Journal-full-title] Chronobiology international
  • [ISO-abbreviation] Chronobiol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] JL5DK93RCL / Melatonin
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36. Bob P, Fedor-Freybergh P: Melatonin, consciousness, and traumatic stress. J Pineal Res; 2008 May;44(4):341-7
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  • Descartes intuitively anticipated the so-called 'binding problem' of consciousness and thought that the pineal gland enables spatio-temporal integration in cognitive processing.
  • Recent findings indicate that a major role in the process of temporal integration and binding involve neurons in suprachiasmatic nuclei, specifically targeting the pineal gland and other structures, and control the neuroendocrine rhythms.
  • [MeSH-minor] Animals. Cerebral Cortex / metabolism. Circadian Rhythm. Gene Expression Regulation. Humans. Long-Term Potentiation. Memory. Mental Disorders / metabolism. Neurons / metabolism. Pineal Gland / metabolism. Suprachiasmatic Nucleus / metabolism

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  • (PMID = 18410583.001).
  • [ISSN] 1600-079X
  • [Journal-full-title] Journal of pineal research
  • [ISO-abbreviation] J. Pineal Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] JL5DK93RCL / Melatonin
  • [Number-of-references] 136
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37. Herwig A, Pévet P, Bothorel B, Steinlechner S, Saboureau M: Trans-pineal microdialysis in the Djungarian hamster (Phodopus sungorus): a tool to study seasonal changes of circadian clock activities. J Pineal Res; 2006 Mar;40(2):177-83
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  • [Title] Trans-pineal microdialysis in the Djungarian hamster (Phodopus sungorus): a tool to study seasonal changes of circadian clock activities.
  • The rhythmic secretion of melatonin by the pineal gland is under control of the circadian clock, conveying the photoperiodic message to the organism.
  • Trans-pineal microdialysis permits the in vivo study of this well-defined and precise clock output by measuring melatonin release directly in the pineal gland.
  • [MeSH-major] Circadian Rhythm / physiology. Melatonin / secretion. Microdialysis / methods. Pineal Gland / secretion

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  • (PMID = 16441555.001).
  • [ISSN] 0742-3098
  • [Journal-full-title] Journal of pineal research
  • [ISO-abbreviation] J. Pineal Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] JL5DK93RCL / Melatonin
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38. Lee CO: Complementary and alternative medicines patients are talking about: melatonin. Clin J Oncol Nurs; 2006 Feb;10(1):105-7
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  • Melatonin (N-acetyl-5-methoxytryptamine) is a hormone produced by the pineal gland in the brain in response to darkness.
  • Melatonin is made available when tryptophan is converted to serotonin and then enzymatically converted to melatonin in the pineal gland.
  • [MeSH-major] Adjuvants, Immunologic / therapeutic use. Antioxidants / therapeutic use. Complementary Therapies / organization & administration. Evidence-Based Medicine / organization & administration. Melatonin / therapeutic use. Neoplasms / drug therapy


39. Spessert R, Gupta BB, Rohleder N, Gerhold S, Engel L: Cyclic AMP-inducible genes respond uniformly to seasonal lighting conditions in the rat pineal gland. Neuroscience; 2006 Dec 1;143(2):607-13
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  • [Title] Cyclic AMP-inducible genes respond uniformly to seasonal lighting conditions in the rat pineal gland.
  • In the present study, we compared the influence of the photoperiodic history on the cAMP-inducible genes AA-NAT, inducible cyclic AMP early repressor (ICER), fos-related antigen-2 (FRA-2), mitogen-activated protein kinase phosphatase-1 (MKP-1), nerve growth factor inducible gene-A (NGFI-A) and nerve growth factor inducible gene-B (NGFI-B) in the pineal gland of rats.
  • For this purpose, we monitored the daily profiles of each gene in the same pineal gland under a long (light/dark 16:8) and a short (light/dark 8:16) photoperiod by measuring the respective mRNA amounts by real-time polymerase chain reaction analysis.
  • Our study indicates that, despite differences regarding the expressional control and the temporal phasing of the daily profile, cAMP-inducible genes are uniformly influenced by photoperiodic history in the rat pineal gland.
  • [MeSH-major] Circadian Rhythm. Cyclic AMP / pharmacology. Cyclic AMP Response Element Modulator / metabolism. Gene Expression Regulation. Light. Pineal Gland


40. Hacker GW, Pawlak E, Pauser G, Tichy G, Jell H, Posch G, Kraibacher G, Aigner A, Hutter J: Biomedical evidence of influence of geopathic zones on the human body: scientifically traceable effects and ways of harmonization. Forsch Komplementarmed Klass Naturheilkd; 2005 Dec;12(6):315-27
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  • [Title] Biomedical evidence of influence of geopathic zones on the human body: scientifically traceable effects and ways of harmonization.
  • It has often been tried to experimentally detect direct influences on the body.
  • The target of this study was to verify influences of 2 different zones above ground on the human body and to test a device for which pilot studies have indicated a potential harmonizing effect in this context.
  • The main analytical parameter was the GDV glow image area (area of glow).
  • With the Geowave blindly mounted in an adjacent room of the above story, a marked increase of the glow image area was found in both zones.
  • The corona projections showed well-recognizable points of body energy deficits in the geopathic zone, mostly associated with the lymphatic system, the cardiovascular system and the pineal gland, which were -- to a distinctly lesser degree -- also present in the more neutral zone.
  • CONCLUSION: The significant differences in the physical area of glow parameter, which were also noticed for the complementary parameters analyzed, lead to the conclusion that the 2 different zones within the same room (geopathic vs. more neutral zone) exerted different influences on the human body, which may have caused a geopathic stress phenomenon.
  • [MeSH-minor] Adolescent. Adult. Aged. Double-Blind Method. Electromagnetic Fields. Energy Metabolism / physiology. Evidence-Based Medicine. Female. Humans. Immune System / physiopathology. Male. Meridians. Middle Aged. Pineal Gland / physiopathology. Reproducibility of Results

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  • (PMID = 16391480.001).
  • [ISSN] 1424-7364
  • [Journal-full-title] Forschende Komplementärmedizin und klassische Naturheilkunde = Research in complementary and natural classical medicine
  • [ISO-abbreviation] Forsch Komplementarmed Klass Naturheilkd
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] Switzerland
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41. Esteban MA, Cuesta A, Rodríguez A, Meseguer J: Effect of photoperiod on the fish innate immune system: a link between fish pineal gland and the immune system. J Pineal Res; 2006 Oct;41(3):261-6
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  • [Title] Effect of photoperiod on the fish innate immune system: a link between fish pineal gland and the immune system.
  • The pineal gland via its secretory product, melatonin, influences the light-dark rhythm in most vertebrates including fish.
  • The present results demonstrate that the humoral innate immune system has a circadian rhythm based on the light-dark cycle and that this cycle might be affected by the pineal gland.
  • [MeSH-major] Bass / immunology. Immunity, Innate / physiology. Photoperiod. Pineal Gland / physiology. Sea Bream / immunology

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  • (PMID = 16948787.001).
  • [ISSN] 0742-3098
  • [Journal-full-title] Journal of pineal research
  • [ISO-abbreviation] J. Pineal Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] JL5DK93RCL / Melatonin
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42. Wang GQ, Fu CL, Li JX, Du YZ, Tong J: Circadian rhythms and different photoresponses of Clock gene transcription in the rat suprachiasmatic nucleus and pineal gland. Sheng Li Xue Bao; 2006 Aug 25;58(4):359-64
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  • [Title] Circadian rhythms and different photoresponses of Clock gene transcription in the rat suprachiasmatic nucleus and pineal gland.
  • The aim of this study was to observe and compare the endogenous circadian rhythm and photoresponse of Clock gene transcription in the suprachiasmatic nucleus (SCN) and pineal gland (PG) of rats.
  • [MeSH-major] CLOCK Proteins / genetics. Circadian Rhythm / physiology. Photoreceptor Cells, Vertebrate / physiology. Pineal Gland / physiology. Suprachiasmatic Nucleus / physiology

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  • (PMID = 16906337.001).
  • [ISSN] 0371-0874
  • [Journal-full-title] Sheng li xue bao : [Acta physiologica Sinica]
  • [ISO-abbreviation] Sheng Li Xue Bao
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] EC 2.3.1.48 / CLOCK Proteins
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43. Doljansky JT, Dagan Y: [A chronobiological approach in treatment of sleep disturbances in Alzheimer's dementia patients]. Harefuah; 2006 Jun;145(6):437-40, 470
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  • The SCN, in turn, innervates the pineal gland, that is responsible for the production and release of melatonin.
  • Light stimulus causes the attenuation of melatonin secretion from the pineal gland; whereas the cessation of light increases melatonin secretion.
  • [MeSH-minor] Chronobiology Phenomena. Humans. Pineal Gland / physiology. Pineal Gland / physiopathology. Signal Transduction. Sleep. Suprachiasmatic Nucleus / physiology. Suprachiasmatic Nucleus / physiopathology. Wakefulness

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  • [CommentIn] Harefuah. 2006 Jun;145(6):433-6, 470 [16838899.001]
  • (PMID = 16838900.001).
  • [ISSN] 0017-7768
  • [Journal-full-title] Harefuah
  • [ISO-abbreviation] Harefuah
  • [Language] heb
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Israel
  • [Number-of-references] 38
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44. Larsen KB, Lutterodt MC, Møllgård K, Møller M: Expression of the homeobox genes OTX2 and OTX1 in the early developing human brain. J Histochem Cytochem; 2010 Jul;58(7):669-78
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  • At later stages, the OTX2 protein was found in the subcommissural organ, pineal gland, and cerebellum.

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  • [Cites] Genes Dev. 1995 Nov 1;9(21):2646-58 [7590242.001]
  • [Cites] Development. 1996 Jan;122(1):243-52 [8565836.001]
  • [Cites] Nat Genet. 1996 Oct;14(2):218-22 [8841200.001]
  • [Cites] Mech Dev. 1996 Aug;58(1-2):165-78 [8887325.001]
  • [Cites] Genes Cells. 1996 Nov;1(11):1031-44 [9077465.001]
  • [Cites] J Neurosci. 1997 Jun 1;17(11):4243-52 [9151741.001]
  • [Cites] Development. 1998 Mar;125(5):845-56 [9449667.001]
  • [Cites] Development. 1999 Feb;126(4):743-57 [9895322.001]
  • [Cites] Nature. 1999 Sep 9;401(6749):161-4 [10490024.001]
  • [Cites] Nature. 1999 Sep 9;401(6749):164-8 [10490025.001]
  • [Cites] Cancer Res. 2005 Feb 1;65(3):703-7 [15705863.001]
  • [Cites] Cancer Res. 2005 Feb 1;65(3):919-24 [15705891.001]
  • [Cites] Am J Hum Genet. 2005 Jun;76(6):1008-22 [15846561.001]
  • [Cites] J Neurosci. 2005 May 25;25(21):5097-108 [15917450.001]
  • [Cites] Brain Res Brain Res Rev. 2005 Sep;49(2):134-49 [16111544.001]
  • [Cites] J Neuropathol Exp Neurol. 2006 Feb;65(2):176-86 [16462208.001]
  • [Cites] BMC Neurosci. 2006;7:16 [16503985.001]
  • [Cites] J Neurochem. 2006 Apr;97(2):556-66 [16539656.001]
  • [Cites] J Neurosci. 2006 May 31;26(22):5955-64 [16738237.001]
  • [Cites] Exp Eye Res. 2007 Jul;85(1):65-73 [17467693.001]
  • [Cites] Development. 2007 Sep;134(17):3167-76 [17670791.001]
  • [Cites] Brain. 2007 Sep;130(Pt 9):2267-76 [17711980.001]
  • [Cites] Neurosci Res. 2008 Apr;60(4):457-9 [18294714.001]
  • [Cites] Development. 2008 Oct;135(20):3459-70 [18820178.001]
  • [Cites] J Biol Chem. 2009 Mar 20;284(12):7606-22 [19103603.001]
  • [Cites] Trends Neurosci. 2009 May;32(5):291-301 [19380167.001]
  • [Cites] Int J Dev Neurosci. 2009 Aug;27(5):485-92 [19414065.001]
  • [Cites] Hum Reprod. 2009 Aug;24(8):1825-33 [19429660.001]
  • [Cites] Cancer Res. 2010 Jan 1;70(1):181-91 [20028867.001]
  • [Cites] Neuron. 1999 Dec;24(4):819-31 [10624946.001]
  • [Cites] Physiol Genomics. 1999 Aug 31;1(2):83-91 [11015565.001]
  • [Cites] Int J Dev Biol. 2001;45(1):367-71 [11291867.001]
  • [Cites] Development. 2001 Jun;128(11):2019-30 [11493524.001]
  • [Cites] Development. 2001 Aug;128(15):2989-3000 [11532921.001]
  • [Cites] Mol Cell Neurosci. 2002 Mar;19(3):430-46 [11906214.001]
  • [Cites] Nat Neurosci. 2003 May;6(5):453-60 [12652306.001]
  • [Cites] Nat Neurosci. 2003 Dec;6(12):1255-63 [14625556.001]
  • [Cites] Development. 2004 May;131(9):2037-48 [15105370.001]
  • [Cites] Eur J Neurosci. 2004 May;19(10):2893-902 [15147323.001]
  • [Cites] J Comp Neurol. 1971 Mar;141(3):283-312 [4101340.001]
  • [Cites] Eur J Obstet Gynecol Reprod Biol. 1979 Aug;9(4):273-80 [400868.001]
  • [Cites] Development. 1990 Jan;108(1):19-31 [2351063.001]
  • [Cites] Anat Embryol (Berl). 1991;184(6):559-69 [1776702.001]
  • [Cites] Nature. 1992 Aug 20;358(6388):687-90 [1353865.001]
  • [Cites] EMBO J. 1993 Jul;12(7):2735-47 [8101484.001]
  • [Cites] Development. 1993 Jan;117(1):97-104 [8223263.001]
  • [Cites] J Neurosci. 1994 Oct;14(10):5725-40 [7931541.001]
  • [Cites] Science. 1995 Jun 16;268(5217):1578-84 [7777856.001]
  • [Cites] Development. 1994 Oct;120(10):2979-89 [7607086.001]
  • [Cites] Development. 1995 Oct;121(10):3279-90 [7588062.001]
  • (PMID = 20354145.001).
  • [ISSN] 1551-5044
  • [Journal-full-title] The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • [ISO-abbreviation] J. Histochem. Cytochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / OTX1 protein, human; 0 / OTX2 protein, human; 0 / Otx Transcription Factors; 0 / RNA, Messenger
  • [Other-IDs] NLM/ PMC2889402
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45. Pritz MB: Forebrain and midbrain fiber tract formation during early development in Alligator embryos. Brain Res; 2010 Feb 8;1313:34-44
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  • With the exception of a few fine fibers that occupied only a part of certain inter-diencephalic boundaries, fiber tracts were present within the parenchyma of respective subdivisions.
  • The other was the absence of the dorsoventral diencephalic tract in Alligator which lacks a pineal gland.

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  • [Copyright] Copyright 2009 Elsevier B.V. All rights reserved.
  • (PMID = 19968970.001).
  • [ISSN] 1872-6240
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Tubulin
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46. Zajac A, Skowronek-Bała B, Wesołowska E, Kaciński M: [The pineal cyst in children with different central nervous system diseases]. Przegl Lek; 2010;67(11):1136-9
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  • [Title] [The pineal cyst in children with different central nervous system diseases].
  • BACKGROUND: In the group of adult patients being diagnosed from different neurological complaints frequency of pineal cyst occurrence is estimated at 0,1-4,9%.
  • However, neoplastic lesions may also localize in pineal cyst.
  • AIM OF THE STUDY: Characterization of pineal cysts found in children diagnosed from different neurological diseases.
  • MR examination with contrast (with the use of Siemens device 1,5 T) revealed lesions in pineal gland defined as pineal cysts.
  • In 24/45 children serum tumor markers AFP and betaHCG were determined.
  • RESULTS: The diameter of pineal cyst was between 3-10 mm in 40/45 children, 13 mm in 2 children and 11 mm in 3 children (most often 4-5 mm in 18 children).
  • No positive values of tumor markers were found in any of examined children.
  • Pineal cysts are common structural lesions in children hospitalized from different neurological symptoms.
  • 2. Pineal cysts were usually found in children diagnosed because of headaches and epilepsy, and these were the most often final diagnosis.
  • 4. It is suspected that in majority of hospitalized patients pineal cyst was an incidental finding, with no association with clinical symptoms.
  • [MeSH-major] Biomarkers, Tumor / blood. Brain Diseases / epidemiology. Cysts / diagnosis. Cysts / epidemiology. Epilepsy / epidemiology. Headache / epidemiology. Pineal Gland

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  • (PMID = 21442964.001).
  • [ISSN] 0033-2240
  • [Journal-full-title] Przegla̧d lekarski
  • [ISO-abbreviation] Prz. Lek.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / alpha-Fetoproteins
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47. Susko I, Mornjaković Z, Alicelebić S: [Early changes in rats cervical lymph nodes after pinealectomy]. Med Arh; 2006;60(3):149-52
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  • OBJECTIVES: Pineal gland acts as a reley where an anabolic activity be replaced to catabolic and conversely, to adapt a biological rhythm according to the organisme requirement.
  • It is established that pineal extracts stimulate lymphopoiesis in the lymph node and had a radioprotective effects in lymph tissues.
  • METHODS: One group of animals ( Wistar rats of both sex) was shame-pinealectomized (chirurgic treatment without pineal extirpation/control) and the other was submitted to surgical ablation of pineal gland.(experimental group).
  • DISCUSSION: Established changes in the lymph nodes of pinealectomized a rat was analogous with that observed after treatment with the pineal extracts but in the reverse means.
  • CONCLUSION: Pineal gland-lymph nodes correlations established possibly via hypophyso-adreno-genital axis.
  • [MeSH-major] Lymph Nodes / pathology. Pineal Gland / surgery

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  • (PMID = 16719226.001).
  • [Journal-full-title] Medicinski arhiv
  • [ISO-abbreviation] Med Arh
  • [Language] bos
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Bosnia and Herzegovina
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48. Holthues H, Engel L, Spessert R, Vollrath L: Circadian gene expression patterns of melanopsin and pinopsin in the chick pineal gland. Biochem Biophys Res Commun; 2005 Jan 7;326(1):160-5
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  • [Title] Circadian gene expression patterns of melanopsin and pinopsin in the chick pineal gland.
  • The directly light-sensitive chick pineal gland contains at least two photopigments.
  • [MeSH-major] Circadian Rhythm / physiology. Gene Expression Regulation / physiology. Gene Expression Regulation / radiation effects. Nerve Tissue Proteins / metabolism. Pineal Gland / metabolism. Pineal Gland / radiation effects. Rod Opsins / metabolism

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  • (PMID = 15567166.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Avian Proteins; 0 / Nerve Tissue Proteins; 0 / Rod Opsins; 0 / melanopsin; 0 / pinopsin protein, chicken
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49. Peliciari-Garcia RA, Marçal AC, Silva JA, Carmo-Buonfiglio D, Amaral FG, Afeche SC, Cipolla-Neto J, Carvalho CR: Insulin temporal sensitivity and its signaling pathway in the rat pineal gland. Life Sci; 2010 Jul 31;87(5-6):169-74
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  • [Title] Insulin temporal sensitivity and its signaling pathway in the rat pineal gland.
  • A second question raised was whether windows of sensitivity to insulin exist in the pineal gland due to insulin rhythmic secretion pattern.
  • MAIN METHODS: Melatonin content from norepinephrine(NE)-synchronized pineal gland cultures was quantified by high performance liquid chromatography with electrochemical detection and arylalkylamine-N-acetyltransferase (AANAT) activity was assayed by radiometry.
  • In some Timed-insulin Stimulation (TSs), insulin also promoted a reduction on melatonin synthesis, showing its dual action in cultured pineal glands.
  • The major ISP components, such as IRbeta, IGF-1R, IRS-1, IRS-2 and PI3K(p85), as well tyrosine phosphorylation of pp85 were characterized within pineal glands.
  • SIGNIFICANCE: The present study demonstrated windows of differential insulin sensitivity, a functional ISP and the PI3K-dependent insulin potentiating effect on NE-mediated melatonin synthesis, supporting the hypothesis of a crosstalk between noradrenergic and insulin pathways in the rat pineal gland.
  • [MeSH-major] Insulin / pharmacology. Melatonin / biosynthesis. Norepinephrine / pharmacology. Pineal Gland / drug effects

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20600146.001).
  • [ISSN] 1879-0631
  • [Journal-full-title] Life sciences
  • [ISO-abbreviation] Life Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / 14-3-3 Proteins; 0 / Insulin; EC 2.3.1.87 / Arylalkylamine N-Acetyltransferase; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; JL5DK93RCL / Melatonin; X4W3ENH1CV / Norepinephrine
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50. Song JH, Kong DS, Shin HJ: Feasibility of neuroendoscopic biopsy of pediatric brain tumors. Childs Nerv Syst; 2010 Nov;26(11):1593-8
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  • Neuroendoscopic biopsies were performed to verify the histological diagnosis of neoplasms and to establish pathological diagnoses necessary for planning appropriate treatment strategies.
  • RESULTS: In 45 of 49 patients (91.8%) neuroendoscopic biopsy specimens were appropriate for diagnosis and revealed 27 germinomas, 11 astrocytomas, and one ependymoma, etc.
  • The tumor location included the pineal gland (n = 28), thalamus (n = 7), intraventricle (n = 3), hypothalamus (n = 3), suprasellar area (n = 2), and diffuse multifocal area (n = 3).
  • Tumor tissue specimens were undiagnostic in two patients (4.1%).
  • One patient experienced postoperative tumor bleeding requiring emergent operation.
  • [MeSH-major] Biopsy / methods. Brain Neoplasms / pathology. Cerebral Ventricle Neoplasms / pathology. Hypothalamic Neoplasms / pathology. Neuroendoscopy / methods. Pinealoma / pathology. Thalamic Diseases / pathology
  • [MeSH-minor] Adolescent. Cerebral Ventricles / pathology. Child. Child, Preschool. Feasibility Studies. Female. Humans. Hypothalamus / pathology. Infant. Male. Pineal Gland / pathology. Postoperative Complications / etiology. Thalamus / pathology. Young Adult

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  • [Cites] Neurosurgery. 1978 Mar-Apr;2(2):110-3 [732959.001]
  • [Cites] Minim Invasive Neurosurg. 1997 Mar;40(1):13-5; discussion 16 [9138302.001]
  • [Cites] J Neurosurg. 1973 Feb;38(2):251-6 [4694225.001]
  • [Cites] Neurosurgery. 2002 Oct;51(4):880-9 [12234394.001]
  • [Cites] Br J Neurosurg. 2002 Oct;16(5):465-70 [12498490.001]
  • [Cites] Br J Neurosurg. 2002 Apr;16(2):93-5 [12046745.001]
  • [Cites] J Neurosurg. 2006 Sep;105(3 Suppl):219-26 [16970236.001]
  • [Cites] J Neurosurg. 2001 Nov;95(5):791-7 [11702869.001]
  • [Cites] J Neurosurg. 1997 Mar;86(3):446-55 [9046301.001]
  • [Cites] J Neurosurg. 2004 May;100(5 Suppl Pediatrics):437-41 [15287451.001]
  • [Cites] Ann Surg. 1933 Nov;98(5):841-5 [17867081.001]
  • [Cites] Minim Invasive Neurosurg. 2001 Jun;44(2):70-3 [11487787.001]
  • [Cites] Neurosurgery. 2006 Aug;59(2):267-77; discussion 267-77 [16883167.001]
  • [Cites] J Neurosurg. 1998 Mar;88(3):496-505 [9488304.001]
  • [Cites] J Neurooncol. 2001 Sep;54(3):277-86 [11767293.001]
  • [Cites] Childs Nerv Syst. 1999 Apr;15(4):179-84 [10361968.001]
  • [Cites] J Neurosurg. 2006 Aug;105(2):271-8 [17219833.001]
  • [Cites] Acta Neurochir (Wien). 2008 Dec;150(12):1235-9 [19002372.001]
  • [Cites] Minim Invasive Neurosurg. 2003 Oct;46(5):293-9 [14628246.001]
  • [Cites] J Neurosurg. 2005 Nov;103(5 Suppl):393-400 [16302610.001]
  • [Cites] Neurosurg Focus. 1999 Apr 15;6(4):e14 [16681354.001]
  • [Cites] Int J Oncol. 2003 Feb;22(2):269-72 [12527921.001]
  • (PMID = 20390421.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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51. Cardoso FR, de Oliveira Cruz FA, Silva D, Cortez CM: Computational modeling of synchronization process of the circadian timing system of mammals. Biol Cybern; 2009 May;100(5):385-93
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  • Circadian timing system in mammals is constituted by a group of structures which includes the suprachiasmatic nucleus, the intergeniculate leaflet and the pineal gland.

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  • (PMID = 19367410.001).
  • [ISSN] 1432-0770
  • [Journal-full-title] Biological cybernetics
  • [ISO-abbreviation] Biol Cybern
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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52. Luchetti F, Canonico B, Mannello F, Masoni C, D'Emilio A, Battistelli M, Papa S, Falcieri E: Melatonin reduces early changes in intramitochondrial cardiolipin during apoptosis in U937 cell line. Toxicol In Vitro; 2007 Mar;21(2):293-301
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  • Melatonin (Mel), the secretory product of the pineal gland, is a potent and efficient endogenous radical scavenger.
  • The cardiolipin-sensitive probe 10-nonyl acridine orange (NAO) was used to monitor changes in mitochondrial lipids.

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  • (PMID = 17045454.001).
  • [ISSN] 1879-3177
  • [Journal-full-title] Toxicology in vitro : an international journal published in association with BIBRA
  • [ISO-abbreviation] Toxicol In Vitro
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cardiolipins; 11062-77-4 / Superoxides; JL5DK93RCL / Melatonin
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53. Grommen SV, Taniuchi S, Janssen T, Schoofs L, Takahashi S, Takeuchi S, Darras VM, De Groef B: Molecular cloning, tissue distribution, and ontogenic thyroidal expression of the chicken thyrotropin receptor. Endocrinology; 2006 Aug;147(8):3943-51
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  • TSH and the interaction with its receptor (TSHR) in the thyroid gland play a crucial role in the pituitary-thyroid axis of all vertebrates.
  • Released upon stimulation by TSH, thyroid hormones influence numerous processes in the body and are extremely important during the last week of chicken embryonic development.
  • In situ hybridization showed the expression of cTSHR mRNA in the thyroidal follicular cells. cTSHR mRNA expression, as determined by real-time PCR, was also found in several other tissues such as brain, pituitary, pineal gland, and retina, suggesting that the TSH-TSHR interaction is not only important in regulating thyroid function.
  • TSHR mRNA expression in the thyroid gland did not change significantly during the last week of embryonic development, which suggests that an increased thyroidal sensitivity is not part of the cause of the concomitant increasing T4 levels.
  • [MeSH-major] Gene Expression Regulation, Developmental. Receptors, Thyrotropin / genetics. Thyroid Gland / embryology. Thyroid Gland / physiology

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  • (PMID = 16709612.001).
  • [ISSN] 0013-7227
  • [Journal-full-title] Endocrinology
  • [ISO-abbreviation] Endocrinology
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AB234613
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Receptors, Thyrotropin; 9002-71-5 / Thyrotropin
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54. Ho AK, Chik CL: Modulation of Aanat gene transcription in the rat pineal gland. J Neurochem; 2010 Jan;112(2):321-31
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  • [Title] Modulation of Aanat gene transcription in the rat pineal gland.
  • The main function of the rat pineal gland is to transform the circadian rhythm generated in the suprachiasmatic nucleus into a rhythmic signal of circulating melatonin characterized by a large nocturnal increase that closely reflects the duration of night period.
  • This review highlights the pineal gland as an excellent model system for studying neurotransmitter-regulated rhythmic gene expression.
  • [MeSH-major] Arylalkylamine N-Acetyltransferase / metabolism. Circadian Rhythm / physiology. Pineal Gland / metabolism

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  • (PMID = 19860854.001).
  • [ISSN] 1471-4159
  • [Journal-full-title] Journal of neurochemistry
  • [ISO-abbreviation] J. Neurochem.
  • [Language] eng
  • [Grant] Canada / Canadian Institutes of Health Research / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Histones; EC 2.3.1.48 / CREB-Binding Protein; EC 2.3.1.87 / Aanat protein, rat; EC 2.3.1.87 / Arylalkylamine N-Acetyltransferase; EC 2.7.11.1 / Aurora Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; JL5DK93RCL / Melatonin
  • [Number-of-references] 100
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55. Chen L, Zhou J, Xu H, Xu G, Xue J: Identification and developmental expression of Dec2 in zebrafish. Fish Physiol Biochem; 2010 Sep;36(3):667-75
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  • Dec2 is dynamically expressed in zebrafish pineal gland, tract of the postoptic commissure, brain, notochord, heart, common cardinal vein (CCV), axial vein, pronephric duct, swim bladder, and early somites during embryogenesis, which implies that Dec2 is involved in zebrafish central nervous system development, cardiogenesis, and internal organs and somites formation.

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  • [Cites] Dev Dyn. 2004 May;230(1):124-30 [15108316.001]
  • [Cites] Int J Mol Med. 2006 Jun;17(6):1053-6 [16685415.001]
  • [Cites] Biochem Biophys Res Commun. 2001 Jan 12;280(1):164-71 [11162494.001]
  • [Cites] Gene Expr Patterns. 2006 Oct;6(8):919-27 [16678499.001]
  • [Cites] Oncogene. 2008 Jul 10;27(30):4200-9 [18345027.001]
  • [Cites] Dev Dyn. 1995 Jul;203(3):253-310 [8589427.001]
  • [Cites] J Biol Chem. 2003 May 30;278(22):20098-109 [12657651.001]
  • [Cites] Int J Mol Med. 2007 Jun;19(6):925-32 [17487425.001]
  • [Cites] Biochem Biophys Res Commun. 2006 Dec 29;351(4):1072-7 [17097613.001]
  • [Cites] Genes Cells. 2008 Feb;13(2):131-44 [18233956.001]
  • [Cites] Mol Cell Neurosci. 1997;10(3-4):460-75 [9532582.001]
  • [Cites] Nucleic Acids Res. 2008 Nov;36(20):6372-85 [18838394.001]
  • [Cites] Genes Dev. 1997 Aug 15;11(16):2052-65 [9284045.001]
  • [Cites] Oncol Rep. 2007 Apr;17 (4):871-8 [17342330.001]
  • [Cites] Protein Sci. 2000 Jun;9(6):1203-9 [10892812.001]
  • [Cites] Biochem Biophys Res Commun. 2008 May 16;369(4):1184-9 [18342625.001]
  • [Cites] Biochem Biophys Res Commun. 1997 Jul 18;236(2):294-8 [9240428.001]
  • [Cites] J Biol Chem. 2002 Dec 6;277(49):47014-21 [12354771.001]
  • [Cites] Biochem Biophys Res Commun. 2005 Oct 14;336(1):364-71 [16125671.001]
  • [Cites] Front Biosci. 2005 Sep 01;10:3151-71 [15970569.001]
  • [Cites] J Biol Chem. 2003 May 9;278(19):16899-907 [12624110.001]
  • [Cites] Gene. 2003 Jul 17;312:335-43 [12909371.001]
  • [Cites] J Biol Chem. 2004 Dec 10;279(50):52643-52 [15448136.001]
  • [Cites] Physiol Rev. 1989 Jul;69(3):671-707 [2664825.001]
  • [Cites] Mol Cell Biol. 1995 Dec;15(12):6923-31 [8524259.001]
  • (PMID = 19578937.001).
  • [ISSN] 1573-5168
  • [Journal-full-title] Fish physiology and biochemistry
  • [ISO-abbreviation] Fish Physiol. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / DNA Primers; 0 / DNA, Complementary; 0 / Dec2 protein, zebrafish; 0 / Zebrafish Proteins
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56. Zajac A, Herman-Sucharska I, Kubik A, Skowronek-Bała B, Gergont A, Szafirska M: [MRI and MRA data in children with migraine with aura]. Przegl Lek; 2007;64(11):934-6
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  • Isolated pathology, such as a calcification of the pineal gland and focal demyelination of vascular origin were detected in individual children.
  • [MeSH-major] Intracranial Aneurysm / diagnosis. Intracranial Arteriovenous Malformations / diagnosis. Magnetic Resonance Imaging. Migraine with Aura / etiology
  • [MeSH-minor] Adolescent. Angiography, Digital Subtraction. Brain / radiography. Child. Diagnosis, Differential. Female. Humans. Magnetic Resonance Angiography. Male


57. Firth BT, Christian KA, Belan I, Kennaway DJ: Melatonin rhythms in the Australian freshwater crocodile (Crocodylus johnstoni): a reptile lacking a pineal complex? J Comp Physiol B; 2010 Jan;180(1):67-72
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  • [Title] Melatonin rhythms in the Australian freshwater crocodile (Crocodylus johnstoni): a reptile lacking a pineal complex?
  • The vertebrate pineal gland is the primary source of melatonin, the rhythmic secretion of which is influenced by environmental light and temperature, thereby providing animals with information about seasonally changing photoperiod and thermoperiod.
  • Although pineal glands are present in the majority of vertebrate species, a discrete organ is reported to be absent in the Crocodilia.

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  • [Cites] Gen Comp Endocrinol. 2003 Jun 1;132(1):161-70 [12765656.001]
  • [Cites] Gen Comp Endocrinol. 1993 Dec;92(3):347-54 [8138102.001]
  • [Cites] Gen Comp Endocrinol. 2004 Jan 15;135(2):217-22 [14697308.001]
  • [Cites] J Pineal Res. 2006 Aug;41(1):15-20 [16842536.001]
  • [Cites] Front Biosci. 2003 May 01;8:s236-42 [12700027.001]
  • [Cites] Experientia. 1993 Aug 15;49(8):665-70 [8359272.001]
  • [Cites] Gen Comp Endocrinol. 1995 Nov;100(2):226-37 [8582604.001]
  • [Cites] Physiol Behav. 1981 Mar;26(3):413-8 [7243958.001]
  • [Cites] J Pineal Res. 2001 Jan;30(1):43-9 [11168906.001]
  • [Cites] Science. 1975 Nov 14;190(4215):671-3 [1237930.001]
  • [Cites] Science. 1977 Feb 11;195(4278):587-9 [835015.001]
  • [Cites] Gen Comp Endocrinol. 1979 Feb;37(2):197-210 [447062.001]
  • [Cites] J Biol Rhythms. 2003 Feb;18(1):63-70 [12568245.001]
  • [Cites] J Biol Rhythms. 1987 Fall;2(3):179-93 [2979659.001]
  • [Cites] J Neurosci. 1998 Feb 1;18(3):1105-14 [9437030.001]
  • [Cites] Physiol Behav. 1993 May;53(5):911-5 [8511207.001]
  • [Cites] J Comp Physiol A. 1996;179(1):135-42 [8965257.001]
  • [Cites] Gen Comp Endocrinol. 1979 Apr;37(4):493-500 [456884.001]
  • [Cites] Am J Physiol. 1999 Dec;277(6 Pt 2):R1620-6 [10600907.001]
  • [Cites] Physiol Behav. 1985 Aug;35(2):267-70 [4070395.001]
  • [Cites] Horm Behav. 2002 Jun;41(4):414-9 [12018937.001]
  • [Cites] Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13816-20 [17715068.001]
  • [Cites] Gen Comp Endocrinol. 1984 Oct;56(1):70-81 [6489741.001]
  • [Cites] Physiol Biochem Zool. 2008 Sep-Oct;81(5):561-9 [18759555.001]
  • [Cites] Endocrinology. 1985 Jul;117(1):226-30 [3924579.001]
  • [Cites] Am J Physiol. 1989 May;256(5 Pt 2):R1160-3 [2719158.001]
  • [Cites] Physiol Biochem Zool. 1999 Jan-Feb;72(1):57-63 [9882603.001]
  • [Cites] Ann N Y Acad Sci. 1994 May 31;719:13-42 [8010588.001]
  • [Cites] Science. 1980 Oct 31;210(4469):548-50 [7423204.001]
  • [Cites] Prog Neurobiol. 1999 Jun;58(2):121-62 [10338357.001]
  • [Cites] Horm Behav. 2002 Jun;41(4):357-65 [12018931.001]
  • [Cites] Gen Comp Endocrinol. 1980 Feb;40(2):180-7 [7189168.001]
  • [Cites] Proc Natl Acad Sci U S A. 1983 Oct;80(19):6119-21 [6577470.001]
  • [Cites] Neurosci Lett. 1989 Nov 20;106(1-2):125-30 [2586818.001]
  • [Cites] Brain Res. 1987 Feb 24;404(1-2):313-8 [3567574.001]
  • (PMID = 19585125.001).
  • [ISSN] 1432-136X
  • [Journal-full-title] Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology
  • [ISO-abbreviation] J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] JL5DK93RCL / Melatonin
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58. Tanuri FC, de Lima E, Peres MF, Cabral FR, da Graça Naffah-Mazzacoratti M, Cavalheiro EA, Cipolla-Neto J, Zukerman E, Amado D: Melatonin treatment decreases c-fos expression in a headache model induced by capsaicin. J Headache Pain; 2009 Apr;10(2):105-10
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  • Our data provide experimental evidence to support the role of melatonin and pineal gland in the pathophysiology of neurovascular headaches.
  • [MeSH-minor] Analysis of Variance. Animals. Capsaicin. Disease Models, Animal. Immunohistochemistry. Injections, Intraperitoneal. Male. Microinjections. Pineal Gland / surgery. Rats. Rats, Wistar

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  • [Cites] Can J Neurol Sci. 1999 Nov;26 Suppl 3:S12-9 [10563228.001]
  • [Cites] Brain Res Brain Res Protoc. 2000 Feb;5(1):109-14 [10719272.001]
  • [Cites] Brain Res Brain Res Rev. 2001 Mar;35(1):20-35 [11245884.001]
  • [Cites] Altern Lab Anim. 1985 Jun;12(4):ii- [11653736.001]
  • [Cites] Cephalalgia. 2001 Dec;21(10):963-75 [11843868.001]
  • [Cites] Cephalalgia. 2001 Dec;21(10):993-5 [11843873.001]
  • [Cites] FASEB J. 2003 Apr;17(6):755-7 [12594180.001]
  • [Cites] Curr Opin Neurol. 2004 Jun;17(3):295-9 [15167064.001]
  • [Cites] Neurology. 2004 Aug 24;63(4):757 [15326268.001]
  • [Cites] J Comp Neurol. 1984 Feb 10;223(1):46-56 [6200513.001]
  • [Cites] Ann Neurol. 1984 Aug;16(2):157-68 [6206779.001]
  • [Cites] Headache. 1984 Nov;24(6):305-9 [6335144.001]
  • [Cites] J Neural Transm Suppl. 1986;21:35-54 [3018145.001]
  • [Cites] Brain Res. 1988 Jul 12;455(2):295-9 [3135922.001]
  • [Cites] Neuron. 1990 Apr;4(4):477-85 [1969743.001]
  • [Cites] Neurol Clin. 1990 Nov;8(4):801-15 [2175382.001]
  • [Cites] Cephalalgia. 1992 Jun;12(3):133-6 [1623506.001]
  • [Cites] Neuroscience. 1992 Aug;49(3):669-80 [1501769.001]
  • [Cites] Br J Pharmacol. 1992 Jun;106(2):409-15 [1327382.001]
  • [Cites] Ann Neurol. 1993 Jan;33(1):48-56 [8388188.001]
  • [Cites] Cell Mol Neurobiol. 1993 Jun;13(3):193-202 [8242684.001]
  • [Cites] Brain Res. 1993 Nov 26;629(1):95-102 [8287282.001]
  • [Cites] Neuropharmacology. 1995 Mar;34(3):255-61 [7630480.001]
  • [Cites] Cephalalgia. 1995 Apr;15(2):136-9; discussion 79 [7641249.001]
  • [Cites] Br J Pharmacol. 1995 Dec;116(8):3199-204 [8719796.001]
  • [Cites] J Pineal Res. 1996 May;20(4):205-10 [8836954.001]
  • [Cites] Cephalalgia. 1996 Nov;16(7):494-6 [8933994.001]
  • [Cites] Neurol Clin. 1997 Feb;15(1):1-13 [9058393.001]
  • [Cites] Neuroreport. 1997 Mar 24;8(5):1123-6 [9175097.001]
  • [Cites] Neurology. 1997 Sep;49(3):650-6 [9305317.001]
  • [Cites] Cephalalgia. 1997 Oct;17(6):683-701 [9350392.001]
  • [Cites] Clin Neurosci. 1998;5(1):2-9 [9523051.001]
  • [Cites] Cephalalgia. 1998 Dec;18(10):664-7 [9950622.001]
  • [Cites] J Cereb Blood Flow Metab. 1999 Feb;19(2):115-27 [10027765.001]
  • [Cites] J Cereb Blood Flow Metab. 1999 May;19(5):511-6 [10326718.001]
  • [Cites] Brain Res. 2005 May 10;1043(1-2):24-31 [15862514.001]
  • [Cites] Cephalalgia. 2005 Jun;25(6):403-11 [15910564.001]
  • [Cites] Expert Opin Investig Drugs. 2006 Apr;15(4):367-75 [16548786.001]
  • [Cites] Cephalalgia. 2006 Aug;26(8):917-9 [16886926.001]
  • [Cites] Neurol Sci. 2008 Sep;29(4):285-7 [18810607.001]
  • (PMID = 19172228.001).
  • [ISSN] 1129-2377
  • [Journal-full-title] The journal of headache and pain
  • [ISO-abbreviation] J Headache Pain
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-fos; JL5DK93RCL / Melatonin; S07O44R1ZM / Capsaicin
  • [Other-IDs] NLM/ PMC3451652
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59. Bellipanni G, DI Marzo F, Blasi F, Di Marzo A: Effects of melatonin in perimenopausal and menopausal women: our personal experience. Ann N Y Acad Sci; 2005 Dec;1057:393-402
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  • It is accepted that a close link exists between the pineal gland, MEL, and human reproduction and that a relationship exists between adenohypophyseal and steroid hormones and MEL during the ovarian cycle, perimenopause, and menopause.

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  • (PMID = 16399909.001).
  • [ISSN] 0077-8923
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogens; 0 / Thyroid Hormones; 4G7DS2Q64Y / Progesterone; 9002-62-4 / Prolactin; 9002-67-9 / Luteinizing Hormone; 9002-68-0 / Follicle Stimulating Hormone; JL5DK93RCL / Melatonin
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60. Wang GQ, Du YZ, Tong J: Daily oscillation and photoresponses of clock gene, Clock, and clock-associated gene, arylalkylamine N-acetyltransferase gene transcriptions in the rat pineal gland. Chronobiol Int; 2007;24(1):9-20
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  • [Title] Daily oscillation and photoresponses of clock gene, Clock, and clock-associated gene, arylalkylamine N-acetyltransferase gene transcriptions in the rat pineal gland.
  • This study was conducted to investigate the circadian rhythms and light responses of Clock and arylalkylamine N-acetyltransferase (NAT) gene expressions in the rat pineal gland under the environmental conditions of a 12 h light (05:00-17:00 h): 12 h-dark (17:00-05:00 h) cycle (LD) and constant darkness (DD).
  • The pineal gland of Sprague-Dawley rats housed under a LD regime (n=42) for four weeks and of a regime (n=42) for eight weeks were sampled at six different times, every 4 h (n=7 animals per time point), during a 24 h period.
  • In the DD or LD condition, both the Clock and NAT mRNA levels in the pineal gland showed robust circadian oscillation (p<0.05) with the peak at the subjective night or at nighttime.
  • In comparison with the DD regime, the amplitudes and mRNA levels at the peaks of Clock and NAT expressions in LD in the pineal gland were significantly reduced (p<0.05).
  • In the DD or LD condition, the circadian expressions of NAT were similar in pattern to those of Clock in the pineal gland (p>0.05).
  • These findings indicate that the transcriptions of Clock and NAT genes in the pineal gland not only show remarkably synchronous endogenous circadian rhythmic changes, but also respond to the ambient light signal in a reduced manner.
  • [MeSH-major] Arylalkylamine N-Acetyltransferase / genetics. Circadian Rhythm / genetics. Gene Expression Regulation / radiation effects. Light. Pineal Gland / radiation effects. Trans-Activators / genetics. Transcription, Genetic / radiation effects

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  • (PMID = 17364576.001).
  • [ISSN] 0742-0528
  • [Journal-full-title] Chronobiology international
  • [ISO-abbreviation] Chronobiol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Trans-Activators; EC 2.3.1.48 / CLOCK Proteins; EC 2.3.1.48 / Clock protein, rat; EC 2.3.1.87 / Arylalkylamine N-Acetyltransferase
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61. Prieto Peres MF, Valença MM: Headache endocrinological aspects. Handb Clin Neurol; 2010;97:717-37
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  • The main elements for synchronization between internal biological events and the external environment are the pineal gland and its main secretory product, melatonin.
  • [MeSH-minor] Animals. Circadian Rhythm. Headache Disorders / drug therapy. Headache Disorders, Primary. Humans. Melatonin. Pineal Gland

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  • [Copyright] Copyright © 2011 Elsevier B.V. All rights reserved.
  • (PMID = 20816466.001).
  • [ISSN] 0072-9752
  • [Journal-full-title] Handbook of clinical neurology
  • [ISO-abbreviation] Handb Clin Neurol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] JL5DK93RCL / Melatonin
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62. Hazlerigg D, Loudon A: New insights into ancient seasonal life timers. Curr Biol; 2008 Sep 09;18(17):R795-R804
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  • In mammals, extraretinal photoreceptors have been lost, and the nocturnal melatonin signal generated from the pineal gland has been co-opted to provide the photoperiodic message.
  • Pineal function is phased to the light-dark cycle by retinal input, and photoperiodic changes in melatonin secretion control neuroendocrine pathway function.
  • [MeSH-minor] Animals. Breeding. Circadian Rhythm. Gene Expression Regulation. Hypothalamo-Hypophyseal System / metabolism. Light Signal Transduction. Models, Biological. Photoperiod. Pituitary Gland / metabolism. Vertebrates / metabolism. Vertebrates / physiology

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  • (PMID = 18786385.001).
  • [ISSN] 0960-9822
  • [Journal-full-title] Current biology : CB
  • [ISO-abbreviation] Curr. Biol.
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / / BB/G003033/1
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 79
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63. Cheung KK, Mok SC, Rezaie P, Chan WY: Dynamic expression of Dab2 in the mouse embryonic central nervous system. BMC Dev Biol; 2008 Aug 04;8:76
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  • Dab2 protein was also identified within circumventricular organs including the choroid plexus, subcommissural organ and pineal gland during their early development.
  • While Dab2 was still strongly expressed in the adult choroid plexus, immunoreactivity within the subcommissural organ and pineal gland was lost after birth.

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  • [Cites] Development. 2000 Mar;127(5):933-44 [10662633.001]
  • [Cites] Cell Signal. 2007 Jun;19(6):1339-47 [17317100.001]
  • [Cites] J Biol Chem. 2000 Jun 30;275(26):19949-54 [10779506.001]
  • [Cites] Neuropathology. 2000 Jun;20(2):134-42 [10935450.001]
  • [Cites] Microsc Res Tech. 2001 Jan 1;52(1):5-20 [11135444.001]
  • [Cites] Genomics. 2000 Dec 15;70(3):381-6 [11161789.001]
  • [Cites] Gene. 2001 May 2;268(1-2):31-9 [11368898.001]
  • [Cites] EMBO J. 2001 Jun 1;20(11):2789-801 [11387212.001]
  • [Cites] J Biol Chem. 2001 Jul 27;276(30):27793-8 [11371563.001]
  • [Cites] Stroke. 2001 May;32(5):1208-15 [11340235.001]
  • [Cites] J Biol Chem. 2001 Dec 14;276(50):47303-10 [11577091.001]
  • [Cites] EMBO J. 2002 Feb 1;21(3):211-20 [11823414.001]
  • [Cites] EMBO J. 2002 Apr 2;21(7):1555-64 [11927540.001]
  • [Cites] Dev Biol. 2002 Nov 1;251(1):27-44 [12413896.001]
  • [Cites] Microsc Res Tech. 2003 Apr 15;60(6):600-13 [12645008.001]
  • [Cites] FEBS Lett. 2003 Apr 24;541(1-3):21-7 [12706813.001]
  • [Cites] EMBO J. 2003 Jun 16;22(12):3084-94 [12805222.001]
  • [Cites] FEBS Lett. 2003 Nov 6;554(1-2):81-7 [14596919.001]
  • [Cites] Histol Histopathol. 2004 Jan;19(1):137-42 [14702181.001]
  • [Cites] Neuron. 2004 Apr 22;42(2):197-211 [15091337.001]
  • [Cites] Development. 2004 Jul;131(14):3367-79 [15226254.001]
  • [Cites] Nature. 1981 May 21;291(5812):235-7 [6164928.001]
  • [Cites] Development. 1987 Jan;99(1):109-26 [3652985.001]
  • [Cites] Development. 1988 Feb;102(2):427-42 [3416778.001]
  • [Cites] Cell. 1989 Jul 14;58(1):103-13 [2502313.001]
  • [Cites] Trends Neurosci. 1990 Aug;13(8):329-35 [1699318.001]
  • [Cites] Trends Genet. 1991 Nov-Dec;7(11-12):351-5 [1820686.001]
  • [Cites] Genes Dev. 1993 Mar;7(3):441-53 [7680635.001]
  • [Cites] J Cell Sci. 1993 Apr;104 ( Pt 4):1021-9 [8314887.001]
  • [Cites] Gynecol Oncol. 1994 Feb;52(2):247-52 [8314147.001]
  • [Cites] Cell. 1994 Jul 29;78(2):191-201 [7913880.001]
  • [Cites] Development. 1995 Mar;121(3):825-37 [7720586.001]
  • [Cites] J Biol Chem. 2007 Apr 27;282(17):13114-22 [17339320.001]
  • [Cites] Hum Mol Genet. 2007 Nov 15;16(22):2751-9 [17761685.001]
  • [Cites] Neurobiol Aging. 2008 Jun;29(6):902-12 [17324488.001]
  • [Cites] J Biol Chem. 2003 Feb 28;278(9):6936-41 [12473651.001]
  • [Cites] J Biol Chem. 1995 Jun 9;270(23):14184-91 [7775479.001]
  • [Cites] Development. 1995 Aug;121(8):2537-47 [7671817.001]
  • [Cites] Int J Dev Biol. 1995 Oct;39(5):809-16 [8645565.001]
  • [Cites] Physiol Rev. 1996 Oct;76(4):927-47 [8874489.001]
  • [Cites] Mol Reprod Dev. 1997 Jan;46(1):24-30 [8981360.001]
  • [Cites] Nature. 1997 Oct 16;389(6652):733-7 [9338785.001]
  • [Cites] Microsc Res Tech. 1998 Apr 15;41(2):98-123 [9579598.001]
  • [Cites] Oncogene. 1998 May 7;16(18):2381-7 [9620555.001]
  • [Cites] Brain Res Mol Brain Res. 1998 Jun 1;57(1):1-9 [9630473.001]
  • [Cites] Endocrinology. 1998 Aug;139(8):3542-53 [9681506.001]
  • [Cites] Oncogene. 1998 Jul 30;17(4):419-24 [9696034.001]
  • [Cites] Oncogene. 1998 Sep 3;17(9):1173-8 [9764828.001]
  • [Cites] Exp Neurol. 1999 May;157(1):194-201 [10222122.001]
  • [Cites] Oncogene. 1999 May 20;18(20):3104-13 [10340382.001]
  • [Cites] Mol Cells. 1999 Apr 30;9(2):179-84 [10340473.001]
  • [Cites] Neurosci Lett. 2005 Apr 18;378(2):88-91 [15774263.001]
  • [Cites] J Biol Chem. 2005 Apr 22;280(16):16484-98 [15722554.001]
  • [Cites] J Biol Chem. 2005 Apr 29;280(17):17540-8 [15734730.001]
  • [Cites] Am J Physiol Renal Physiol. 2005 Sep;289(3):F569-76 [15870384.001]
  • [Cites] J Neurosci. 2005 Nov 23;25(47):10884-93 [16306401.001]
  • [Cites] J Neurosci. 2006 Feb 8;26(6):1767-75 [16467525.001]
  • [Cites] Brain Res Rev. 2007 Feb;53(2):344-54 [17188751.001]
  • [Cites] Biochem J. 2000 May 1;347 Pt 3:613-21 [10769163.001]
  • (PMID = 18680569.001).
  • [ISSN] 1471-213X
  • [Journal-full-title] BMC developmental biology
  • [ISO-abbreviation] BMC Dev. Biol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R33 CA103595; United States / NCI NIH HHS / CA / P50CA165009; United States / NCI NIH HHS / CA / R33CA103595
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adaptor Proteins, Vesicular Transport; 0 / Dab2 protein, mouse
  • [Other-IDs] NLM/ PMC2527319
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64. Ackermann K, Bux R, Rüb U, Korf HW, Kauert G, Stehle JH: Characterization of human melatonin synthesis using autoptic pineal tissue. Endocrinology; 2006 Jul;147(7):3235-42
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  • [Title] Characterization of human melatonin synthesis using autoptic pineal tissue.
  • The mammalian pineal gland synthesizes rhythmically the hormone melatonin, which provides the body with a signal coding the duration of the night period.
  • In contrast to the central importance of a transcriptional regulation of the Aa-nat gene for rodent melatonin synthesis, mechanisms in the human pineal gland are elusive.
  • Therefore, pineal tissue, taken from regular autopsies (n = 69; postmortem intervals ranging from 9 to 147 h) was analyzed simultaneously for Aa-nat and Hiomt mRNA levels by PCR, AA-NAT activity using (14)C-acetyl-coenzyme A, HIOMT activity using S-adenosyl-l-[(14)C]-methionine, and melatonin content using an ELISA.
  • In particular, our results give strong experimental support for the idea that transcriptional mechanisms are not dominant for the generation of rhythmic melatonin synthesis in the human pineal gland.
  • [MeSH-major] Melatonin / biosynthesis. Pineal Gland / pathology

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  • (PMID = 16556767.001).
  • [ISSN] 0013-7227
  • [Journal-full-title] Endocrinology
  • [ISO-abbreviation] Endocrinology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.1.1.4 / Acetylserotonin O-Methyltransferase; EC 2.3.1.87 / Arylalkylamine N-Acetyltransferase; JL5DK93RCL / Melatonin
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65. Leclerc B, Kang SW, Mauro LJ, Kosonsiriluk S, Chaiseha Y, El Halawani ME: Photoperiodic modulation of clock gene expression in the avian premammillary nucleus. J Neuroendocrinol; 2010 Feb;22(2):119-28
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  • The premammillary nucleus (PMM) has been shown to contain a daily endogenous dual-oscillation in dopamine (DA)/melatonin (MEL) as well as c-fos mRNA expression that is associated with the daily photo-inducible phase of gonad growth in turkeys.
  • In the present study, the expression of clock genes (Bmal1, Clock, Cry1, Cry2, Per2 and Per3) in the PMM was determined under short (8 : 16 h light/dark cycle) and long (16 : 8 h light/dark cycle) photoperiods relative to changes associated with the diurnal rhythm of DA and MEL.
  • Gene expression in established circadian pacemakers, the visual suprachiasmatic nucleus (vSCN) and the pineal, was also determined.
  • Clock genes in the pineal gland were rhythmic under both photoperiods, and were not altered after light pulses at ZT 14, which suggests that pineal clock genes may not be associated with the photosensitive phase and reproductive activities.
  • Taken together, the changes in clock gene expression observed within the PMM were unique compared to the pineal and vSCN, and were induced by long photoperiod and light during the daily photosensitive phase; stimuli that are also documented to promote reproductive activity.
  • [MeSH-minor] Animals. Female. Immunohistochemistry. In Situ Hybridization. Light. Microdissection. Neurons / metabolism. Photoperiod. Pineal Gland / metabolism. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Suprachiasmatic Nucleus / metabolism. Time Factors. Turkeys

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  • (PMID = 20002961.001).
  • [ISSN] 1365-2826
  • [Journal-full-title] Journal of neuroendocrinology
  • [ISO-abbreviation] J. Neuroendocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Avian Proteins; 0 / RNA, Messenger
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66. Magnanou E, Attia J, Fons R, Boeuf G, Falcon J: The timing of the shrew: continuous melatonin treatment maintains youthful rhythmic activity in aging Crocidura russula. PLoS One; 2009;4(6):e5904
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  • 1) The diel fluctuations of melatonin levels in young, adult and aging shrews were quantified in the pineal gland and plasma.
  • [MeSH-major] Melatonin / administration & dosage. Melatonin / metabolism. Melatonin / physiology. Pineal Gland / metabolism. Shrews / physiology

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  • [Cites] Mech Ageing Dev. 1999 Oct 22;110(3):157-73 [10576246.001]
  • [Cites] Neurobiol Aging. 2008 Mar;29(3):464-70 [17123666.001]
  • [Cites] Genetics. 2000 Nov;156(3):927-31 [11063673.001]
  • [Cites] Am J Physiol Regul Integr Comp Physiol. 2001 May;280(5):R1582-91 [11294784.001]
  • [Cites] Reproduction. 2001 Feb;121(2):323-9 [11226057.001]
  • [Cites] Neuroscience. 2001;105(2):403-12 [11672607.001]
  • [Cites] Am J Physiol Regul Integr Comp Physiol. 2002 May;282(5):R1382-8 [11959680.001]
  • [Cites] J Nutr. 2002 Jun;132(6 Suppl 2):1583S-97S [12042467.001]
  • [Cites] Chronobiol Int. 2002 Nov;19(6):1171-82 [12511033.001]
  • [Cites] Exp Gerontol. 2003 Jan-Feb;38(1-2):199-206 [12543278.001]
  • [Cites] J Pineal Res. 2004 Apr;36(3):165-70 [15009506.001]
  • [Cites] J Pineal Res. 2004 May;36(4):256-61 [15066050.001]
  • [Cites] Biometrics. 1976 JUN;32(2):429-34 [953139.001]
  • [Cites] Mammalia. 1976;40(2):299-311 [976573.001]
  • [Cites] Nature. 1977 Nov 24;270(5635):301-4 [593350.001]
  • [Cites] J Theor Biol. 1978 May 8;72(1):131-60 [566361.001]
  • [Cites] Science. 1980 Dec 19;210(4476):1372-3 [7434032.001]
  • [Cites] Endocrinology. 1981 Oct;109(4):1295-7 [7285872.001]
  • [Cites] Endocrinology. 1981 Nov;109(5):1796-8 [7297507.001]
  • [Cites] Comp Biochem Physiol B. 1978;61(1):77-80 [318366.001]
  • [Cites] J Pineal Res. 1990;8(2):179-92 [2352118.001]
  • [Cites] Int J Neurosci. 1990 May;52(1-2):85-92 [2265926.001]
  • [Cites] Respir Physiol. 1991 Aug;85(2):139-49 [1947455.001]
  • [Cites] Brain Res Bull. 1993;30(1-2):157-62 [8420626.001]
  • [Cites] Neurobiol Aging. 1993 Nov-Dec;14(6):565-9 [8295659.001]
  • [Cites] J Pineal Res. 1995 Jan;18(1):32-40 [7776177.001]
  • [Cites] J Exp Biol. 1997 May;200(Pt 10):1451-8 [9192497.001]
  • [Cites] Ageing Res Rev. 2008 Jul;7(3):225-33 [18672097.001]
  • [Cites] Recent Prog Horm Res. 1997;52:307-57; discussion 357-8 [9238858.001]
  • [Cites] Am J Physiol. 1997 Dec;273(6 Pt 2):R2132-7 [9435671.001]
  • [Cites] J Pineal Res. 1998 Sep;25(2):106-15 [9755032.001]
  • [Cites] J Auton Nerv Syst. 1998 Nov 25;74(1):49-61 [9858124.001]
  • [Cites] Therapie. 1998 Sep-Oct;53(5):473-8 [9921040.001]
  • [Cites] J Exp Biol. 1999 Sep;202(Pt 18):2461-73 [10460733.001]
  • [Cites] J Pineal Res. 2005 Apr;38(3):145-52 [15725334.001]
  • [Cites] J Pineal Res. 2005 Oct;39(3):231-7 [16150102.001]
  • [Cites] Chronobiol Int. 2006;23(1-2):451-60 [16687318.001]
  • [Cites] J Pineal Res. 2007 Jan;42(1):28-42 [17198536.001]
  • [Cites] Neurochem Int. 2007 Mar;50(4):571-80 [17276551.001]
  • [Cites] J Pineal Res. 2007 Apr;42(3):272-9 [17349026.001]
  • [Cites] J Biol Rhythms. 1999 Dec;14(6):449-59 [10643741.001]
  • (PMID = 19526053.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] JL5DK93RCL / Melatonin
  • [Other-IDs] NLM/ PMC2690841
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67. Chaurasia SS, Rollag MD, Jiang G, Hayes WP, Haque R, Natesan A, Zatz M, Tosini G, Liu C, Korf HW, Iuvone PM, Provencio I: Molecular cloning, localization and circadian expression of chicken melanopsin (Opn4): differential regulation of expression in pineal and retinal cell types. J Neurochem; 2005 Jan;92(1):158-70
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  • [Title] Molecular cloning, localization and circadian expression of chicken melanopsin (Opn4): differential regulation of expression in pineal and retinal cell types.
  • The avian retina and pineal gland contain autonomous circadian oscillators and photo-entrainment pathways, but the photopigment(s) that mediate entrainment have not been definitively identified.
  • Here, we report the cDNA cloning of chicken melanopsin and show its expression in retina, brain and pineal gland.
  • In pineal gland, expression was strong throughout the parenchyma of the gland.
  • In brain, expression was observed in a few discrete nuclei, including the lateral septal area and medial preoptic nucleus.
  • The retina and pineal gland showed distinct diurnal expression patterns.
  • In pineal gland, melanopsin mRNA levels were highest at night at Zeitgeber time (ZT) 16.
  • Expression of melanopsin mRNA peaked during the daytime in the retinal pigment epithelium and inner nuclear layer but, like in the pineal, at night in the photoreceptors.
  • Localization and regulation of melanopsin mRNA in the retina and pineal gland is consistent with the hypothesis that this novel photopigment plays a role in photic regulation of circadian function in these tissues.

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  • (PMID = 15606905.001).
  • [ISSN] 0022-3042
  • [Journal-full-title] Journal of neurochemistry
  • [ISO-abbreviation] J. Neurochem.
  • [Language] ENG
  • [Databank-accession-numbers] GENBANK/ AY036061
  • [Grant] United States / NEI NIH HHS / EY / R01 EY004864; United States / NEI NIH HHS / EY / EY04864; United States / NIMH NIH HHS / MH / MH62405; United States / NINDS NIH HHS / NS / NS43459
  • [Publication-type] Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Rod Opsins; 0 / melanopsin
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68. Olszańska B, Majewski P, Lewczuk B, Stepińska U: Melatonin and its synthesizing enzymes (arylalkylamine N-acetyltransferase-like and hydroxyindole-O-methyltransferase) in avian eggs and early embryos. J Pineal Res; 2007 Apr;42(3):310-8
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  • The activity of AA-NAT in yolk was comparable with that found in the pineal gland when calculated per milligram of yolk or pineal gland, but was significantly lower when re-calculated per milligram of protein in the yolk or pineal gland.

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  • [ErratumIn] J Pineal Res. 2007 Oct;43(3):315. Bozenna, Olszańska [corrected to Olszańska, Bozenna]; Paweł, Majewski [corrected to Majewski, Paweł]; Bogdan, Lewczuk [corrected to Lewczuk, Bogdan]; Urszula, Stepińska [corrected to Stepińska, Urszula]
  • (PMID = 17349030.001).
  • [ISSN] 0742-3098
  • [Journal-full-title] Journal of pineal research
  • [ISO-abbreviation] J. Pineal Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 2.1.1.4 / Acetylserotonin O-Methyltransferase; EC 2.3.1.87 / Arylalkylamine N-Acetyltransferase; JL5DK93RCL / Melatonin
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69. Goncharova ND, Vengerin AA, Khavinson VKh, Lapin BA: Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and the pancreas. Exp Gerontol; 2005 Jan-Feb;40(1-2):51-7
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  • [Title] Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and the pancreas.
  • The purpose of this research was to study age-related changes in functioning of pineal and pancreatic glands of non-human primates, rhesus monkeys, and to elucidate the possibility of their corrections with the help of epitalon, a synthetic analogue of the pharmacopoeia drug epithalamin.
  • After the glucose administration to old monkeys, a larger area under the curve of the plasma glucose response, a reduced glucose 'disappearance' rate, and a reduced insulin peak (5 min after the glucose administration) were observed in comparison with young animals in similar experiments.
  • Additionally, in the case of old monkeys, epitalon decreased the area under the plasma glucose response curve, markedly increased the glucose 'disappearance' rate and normalized the plasma insulin dynamics in response to glucose administration.
  • [MeSH-major] Aging / physiology. Islets of Langerhans / physiopathology. Oligopeptides / pharmacology. Pineal Gland / physiopathology

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  • (PMID = 15664732.001).
  • [ISSN] 0531-5565
  • [Journal-full-title] Experimental gerontology
  • [ISO-abbreviation] Exp. Gerontol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / Insulin; 0 / Oligopeptides; JL5DK93RCL / Melatonin; O65P17785G / alanyl-glutamyl-aspartyl-glycine
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70. Zhang R, Hrushesky WJ, Wood PA, Lee SH, Hunt RC, Jahng WJ: Melatonin reprogrammes proteomic profile in light-exposed retina in vivo. Int J Biol Macromol; 2010 Aug 01;47(2):255-60
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  • Melatonin, a small organic molecule synthesized by the pineal gland and the retina, has a variety of physiologic functions such as circadian clock pacemaker and antioxidant.

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  • [Copyright] Copyright 2010 Elsevier B.V. All rights reserved.
  • [Cites] Free Radic Biol Med. 2005 Jun 15;38(12):1543-52 [15917183.001]
  • [Cites] Invest Ophthalmol. 1966 Oct;5(5):450-73 [5929286.001]
  • [Cites] Neuron. 1994 Nov;13(5):1177-85 [7946354.001]
  • [Cites] Cell Mol Life Sci. 2003 Oct;60(10):2272-8 [14618273.001]
  • [Cites] Electrophoresis. 1997 Dec;18(14):2537-41 [9527482.001]
  • [Cites] Nat Med. 1995 Dec;1(12):1254-5 [7489404.001]
  • [Cites] Mol Pharmacol. 2006 Oct;70(4):1220-9 [16837623.001]
  • [Cites] Vision Res. 1989;29(2):167-79 [2800345.001]
  • [Cites] Biochemistry. 1994 Mar 15;33(10):3106-12 [8130225.001]
  • [Cites] Nat Genet. 2000 May;25(1):63-6 [10802658.001]
  • [Cites] PLoS Pathog. 2009 Jan;5(1):e1000275 [19165338.001]
  • [Cites] J Neurosci Res. 2009 Aug 1;87(10 ):2365-74 [19301424.001]
  • [Cites] Exp Eye Res. 1978 Sep;27(3):323-33 [361425.001]
  • [Cites] Neuroscience. 1999;93(2):793-9 [10465462.001]
  • [Cites] Biochemistry. 2003 May 27;42(20):6159-68 [12755618.001]
  • [Cites] Invest Ophthalmol Vis Sci. 1998 Nov;39(12):2374-83 [9804146.001]
  • [Cites] Cell Tissue Res. 1981;217(1):105-15 [7018690.001]
  • [Cites] Ann N Y Acad Sci. 2005 Dec;1057:384-92 [16399908.001]
  • [Cites] Vis Neurosci. 2006 Nov-Dec;23(6):853-62 [17266777.001]
  • [Cites] Endocrine. 2005 Jul;27(2):119-30 [16217125.001]
  • [Cites] Science. 1972 Aug 11;177(4048):532-3 [5050487.001]
  • [Cites] Proc Natl Acad Sci U S A. 1991 May 1;88(9):3652-6 [2023914.001]
  • [Cites] Neuroreport. 2001 Apr 17;12(5):1011-4 [11303736.001]
  • [Cites] J Pineal Res. 2007 Jan;42(1):28-42 [17198536.001]
  • (PMID = 20434483.001).
  • [ISSN] 1879-0003
  • [Journal-full-title] International journal of biological macromolecules
  • [ISO-abbreviation] Int. J. Biol. Macromol.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / P20 RR023476
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Proteome; 0 / Vimentin; JL5DK93RCL / Melatonin
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71. Ishido M: Melatonin inhibits maneb-induced aggregation of alpha-synuclein in rat pheochromocytoma cells. J Pineal Res; 2007 Mar;42(2):125-30
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  • Melatonin, a secretory product of the pineal gland, is involved in the regulation of circadian and seasonal rhythms, in oncostasis, and in inducing osteoblast differentiation.
  • [MeSH-major] Adrenal Gland Neoplasms / metabolism. Fungicides, Industrial / antagonists & inhibitors. Maneb / antagonists & inhibitors. Melatonin / physiology. Pheochromocytoma / metabolism. alpha-Synuclein / antagonists & inhibitors. alpha-Synuclein / metabolism

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  • (PMID = 17286743.001).
  • [ISSN] 0742-3098
  • [Journal-full-title] Journal of pineal research
  • [ISO-abbreviation] J. Pineal Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Fungicides, Industrial; 0 / alpha-Synuclein; 12427-38-2 / Maneb; JL5DK93RCL / Melatonin
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72. Drobnik J, Olczak S, Owczarek K, Hrabec Z, Hrabec E: Melatonin augments expression of the procollagen α1 (I) and α1 (III) genes in the infarcted heart scar of pinealectomized rats. Connect Tissue Res; 2010 Dec;51(6):491-6
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  • The pineal gland is involved in the regulation of collagen accumulation in peripheral wounds and scars of the infarcted heart.
  • This study is aimed to provide an explanation of whether the pineal gland and melatonin (MLT) is involved in the regulation of α1 (I) and α1 (III) procollagen gene expression.
  • Because the pineal product does not have an influence on the myofibroblast of the scar, the indirect mechanism of MLT action is suggested.
  • [MeSH-major] Cicatrix / metabolism. Collagen Type I / biosynthesis. Collagen Type III / biosynthesis. Melatonin / administration & dosage. Myocardial Infarction / metabolism. Pineal Gland / physiology. Procollagen / biosynthesis. Up-Regulation / genetics

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  • (PMID = 20388018.001).
  • [ISSN] 1607-8438
  • [Journal-full-title] Connective tissue research
  • [ISO-abbreviation] Connect. Tissue Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Collagen Type I; 0 / Collagen Type III; 0 / Procollagen; 0 / collagen type I, alpha 1 chain; JL5DK93RCL / Melatonin
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73. Rosiak J, Zawilska JB: Near-ultraviolet light perceived by the retina generates the signal suppressing melatonin synthesis in the chick pineal gland-an involvement of NMDA glutamate receptors. Neurosci Lett; 2005 May 13;379(3):214-7
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  • [Title] Near-ultraviolet light perceived by the retina generates the signal suppressing melatonin synthesis in the chick pineal gland-an involvement of NMDA glutamate receptors.
  • Exposure of dark-adapted chicks to near ultraviolet (UV-A) light significantly decreased melatonin (MEL) content and the activity of serotonin N-acetyltransferase (AA-NAT; the penultimate and key regulatory enzyme in MEL production) in the pineal glands.
  • Significant reduction in MEL level and AA-NAT activity was also found in pineals of animals whose heads were covered with black opaque tape, an observation suggesting that in the chicken UV-A light perceived by the eyes alone is capable of affecting MEL synthesis in the pineal gland.
  • Although SCH 23390 (a selective D1-dopamine receptor antagonist), injected directly into both eyes at a dose of 10 nmol/eye, prevented the decline in pineal AA-NAT activity produced by retinal illumination with white light, the drug did not modify the UV-A light-evoked decrease in the enzyme activity.
  • MK-801 (a selective antagonist of NMDA glutamate receptors; 1 nmol/eye) abolished the suppressive action of UV-A light on pineal AA-NAT activity, but it was inactive in the case of white light.
  • Intraocularly injected sulpiride and CNQX (selective antagonists of D2-dopamine and AMPA/kainite glutamate receptors, respectively) had no effect on the actions of both UV-A and white light (acting on the eyes only) on pineal AA-NAT activity.
  • It is concluded that in the chick retinally perceived UV-A light generates a signal which suppresses MEL production in the pineal gland.
  • [MeSH-major] Melatonin / biosynthesis. Pineal Gland / radiation effects. Receptors, N-Methyl-D-Aspartate / physiology. Retina / radiation effects. Ultraviolet Rays

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  • (PMID = 15843066.001).
  • [ISSN] 0304-3940
  • [Journal-full-title] Neuroscience letters
  • [ISO-abbreviation] Neurosci. Lett.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Benzazepines; 0 / Dopamine Antagonists; 0 / Excitatory Amino Acid Antagonists; 0 / Receptors, N-Methyl-D-Aspartate; 6LR8C1B66Q / Dizocilpine Maleate; 6OTE87SCCW / 6-Cyano-7-nitroquinoxaline-2,3-dione; EC 2.3.1.87 / Arylalkylamine N-Acetyltransferase; JL5DK93RCL / Melatonin
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74. du Plessis SS, Hagenaar K, Lampiao F: The in vitro effects of melatonin on human sperm function and its scavenging activities on NO and ROS. Andrologia; 2010 Apr;42(2):112-6
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  • Various systems of antioxidants exist endogenously in the body to help protect it against free radical damage by scavenging excessive ROS and RNS.
  • Melatonin, a hormone secreted by the pineal gland, and responsible for controlling the circadian rhythm, is one such endogenous antioxidant.
  • Spermatozoa were incubated with 2 mm melatonin (120 min, 37 degrees C, 5% CO(2)) after which motility parameters were measured by computer aided motility analysis, while cell viability (PI), intracellular NO (DAF-2/DA) and ROS (DCFH-DA) were assessed using flow cytometry.

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  • (PMID = 20384801.001).
  • [ISSN] 1439-0272
  • [Journal-full-title] Andrologia
  • [ISO-abbreviation] Andrologia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Free Radical Scavengers; 0 / Reactive Oxygen Species; 31C4KY9ESH / Nitric Oxide; JL5DK93RCL / Melatonin
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75. Canpolat S, Aydin M, Yasar A, Colakoglu N, Yilmaz B, Kelestimur H: Effects of pinealectomy and exogenous melatonin on immunohistochemical ghrelin staining of arcuate nucleus and serum ghrelin leves in the rat. Neurosci Lett; 2006 Dec 20;410(2):132-6
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  • Lack of effect of melatonin on hypothalamic ghrelin in PNX rats implicates that exogenous melatonin requires an intact pineal to exert its effects.
  • We have demonstrated for the first time that the pineal gland may play a role in ghrelin amount in the hypothalamus.
  • [MeSH-major] Arcuate Nucleus of Hypothalamus / drug effects. Melatonin / pharmacology. Peptide Hormones / metabolism. Pineal Gland / physiology
  • [MeSH-minor] Analysis of Variance. Animals. Body Weight / drug effects. Body Weight / physiology. Eating / drug effects. Eating / physiology. Ghrelin. Immunohistochemistry / methods. Male. Rats. Rats, Sprague-Dawley

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  • (PMID = 17095160.001).
  • [ISSN] 0304-3940
  • [Journal-full-title] Neuroscience letters
  • [ISO-abbreviation] Neurosci. Lett.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Ghrelin; 0 / Peptide Hormones; JL5DK93RCL / Melatonin
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76. Boudreau EA, Johnson KP, Jackman AR, Blancato J, Huizing M, Bendavid C, Jones M, Chandrasekharappa SC, Lewy AJ, Smith AC, Magenis RE: Review of disrupted sleep patterns in Smith-Magenis syndrome and normal melatonin secretion in a patient with an atypical interstitial 17p11.2 deletion. Am J Med Genet A; 2009 Jul;149A(7):1382-91
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  • Smith-Magenis syndrome (SMS) is a disorder characterized by multiple congenital anomalies and behavior problems, including abnormal sleep patterns.
  • Secretion of melatonin, a hormone produced by the pineal gland, is the body's signal for nighttime darkness.

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  • [Cites] Curr Opin Neurol. 2007 Apr;20(2):125-34 [17351481.001]
  • [Cites] Am J Med Genet A. 2006 Nov 15;140(22):2454-63 [17041942.001]
  • [Cites] Am J Med Genet. 1999 Dec 3;87(4):342-8 [10588842.001]
  • [Cites] J Med Genet. 2000 Jun;37(6):428-33 [10851253.001]
  • [Cites] Am J Med Genet. 2000 Dec 18;95(5):467-72 [11146468.001]
  • [Cites] Psychiatry Clin Neurosci. 2001 Jun;55(3):305-10 [11422885.001]
  • [Cites] J Pediatr. 2001 Jul;139(1):111-6 [11445803.001]
  • [Cites] J Med Genet. 2001 Sep;38(9):586-90 [11546826.001]
  • [Cites] N Engl J Med. 2001 Dec 20;345(25):1825-32 [11752360.001]
  • [Cites] Nat Genet. 2003 Apr;33(4):466-8 [12652298.001]
  • [Cites] Am J Hum Genet. 2003 May;72(5):1101-16 [12649807.001]
  • [Cites] Biomed Pharmacother. 2003 Oct;57 Suppl 1:31s-34s [14572674.001]
  • [Cites] Am J Hum Genet. 2004 Jul;75(1):75-81 [15148657.001]
  • [Cites] Science. 1978 Aug 25;201(4357):741-3 [675255.001]
  • [Cites] Science. 1980 Dec 12;210(4475):1267-9 [7434030.001]
  • [Cites] Lancet. 1981 Feb 14;1(8216):383-4 [6110011.001]
  • [Cites] Endocrinology. 1985 Jul;117(1):226-30 [3924579.001]
  • [Cites] Am J Med Genet. 1986 Jul;24(3):393-414 [2425619.001]
  • [Cites] Am J Hum Genet. 1991 Dec;49(6):1207-18 [1746552.001]
  • [Cites] N Engl J Med. 1995 Jan 5;332(1):6-11 [7990870.001]
  • [Cites] Am J Med Genet. 1996 Mar 29;62(3):247-54 [8882782.001]
  • [Cites] J Biol Rhythms. 1997 Oct;12(5):457-66 [9376644.001]
  • [Cites] J Biol Rhythms. 1997 Dec;12(6):588-94 [9406034.001]
  • [Cites] Am J Med Genet. 1998 Mar 28;81(2):186-91 [9613860.001]
  • [Cites] Curr Biol. 1998 Jul 30-Aug 13;8(16):919-22 [9707402.001]
  • [Cites] Nucleic Acids Res. 1999 Jan 15;27(2):573-80 [9862982.001]
  • [Cites] Genomics. 1999 Apr 1;57(1):180-2 [10191102.001]
  • [Cites] J Med Genet. 2005 Nov;42(11):820-8 [15788730.001]
  • [Cites] Chronobiol Int. 2005;22(6):1093-106 [16393710.001]
  • [Cites] Pediatr Neurol. 2006 May;34(5):337-50 [16647992.001]
  • [Cites] J Autism Dev Disord. 2006 May;36(4):541-52 [16570214.001]
  • [Cites] J Dev Behav Pediatr. 2006 Jun;27(3):188-92 [16775514.001]
  • [Cites] Alcohol Alcohol. 2006 Jul-Aug;41(4):386-90 [16679342.001]
  • [Cites] Sleep. 2007 Nov;30(11):1445-59 [18041479.001]
  • (PMID = 19530184.001).
  • [ISSN] 1552-4833
  • [Journal-full-title] American journal of medical genetics. Part A
  • [ISO-abbreviation] Am. J. Med. Genet. A
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / HD042125-05; United States / NICHD NIH HHS / HD / R01 HD042125; United States / NICHD NIH HHS / HD / R01 HD042125-05; United States / Intramural NIH HHS / /
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] JL5DK93RCL / Melatonin
  • [Other-IDs] NLM/ NIHMS135387; NLM/ PMC2760428
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77. Jaworek J, Nawrot-Porabka K, Leja-Szpak A, Bonior J, Szklarczyk J, Kot M, Konturek SJ, Pawlik WW: Melatonin as modulator of pancreatic enzyme secretion and pancreatoprotector. J Physiol Pharmacol; 2007 Dec;58 Suppl 6:65-80
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  • Melatonin, the main product of the pineal gland, is also released from the gastrointestinal endocrine-neurocrine (EE) cells.

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  • (PMID = 18212401.001).
  • [ISSN] 0867-5910
  • [Journal-full-title] Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
  • [ISO-abbreviation] J. Physiol. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Free Radical Scavengers; 0 / Receptor, Cholecystokinin A; 888Y08971B / Ceruletide; 8DUH1N11BX / Tryptophan; 9011-97-6 / Cholecystokinin; EC 3.2.1.- / Amylases; JL5DK93RCL / Melatonin
  • [Number-of-references] 64
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78. Huang Z, Liu T, Borjigin J: N-terminal residues regulate proteasomal degradation of AANAT. J Pineal Res; 2010 Apr;48(3):290-6
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  • We have shown that inhibition of proteasome activities in vivo in the intact pineal gland fails to prevent the light-induced suppression of melatonin secretion.
  • These results suggest that rat AANAT protein is degraded via the N-end rule pathway of proteasomal proteolysis and the leucine at the N-terminus appears to be the key residue recognized by N-end rule pathway.

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  • (PMID = 20210853.001).
  • [ISSN] 1600-079X
  • [Journal-full-title] Journal of pineal research
  • [ISO-abbreviation] J. Pineal Res.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS057583
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Cysteine Proteinase Inhibitors; 0 / Leupeptins; 0 / Proteasome Inhibitors; 133407-82-6 / benzyloxycarbonylleucyl-leucyl-leucine aldehyde; EC 2.3.1.87 / Aanat protein, rat; EC 2.3.1.87 / Arylalkylamine N-Acetyltransferase; EC 3.4.25.1 / Proteasome Endopeptidase Complex; JL5DK93RCL / Melatonin
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79. Paul S, Sharma AV, Mahapatra PD, Bhattacharya P, Reiter RJ, Swarnakar S: Role of melatonin in regulating matrix metalloproteinase-9 via tissue inhibitors of metalloproteinase-1 during protection against endometriosis. J Pineal Res; 2008 May;44(4):439-49
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  • The effect of melatonin, a major secretory product of the pineal gland, on endometriosis was examined in preventive and therapeutic models in mice.

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  • (PMID = 18298469.001).
  • [ISSN] 1600-079X
  • [Journal-full-title] Journal of pineal research
  • [ISO-abbreviation] J. Pineal Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Enzyme Precursors; 0 / Tissue Inhibitor of Metalloproteinase-1; EC 3.4.24.- / pro-matrix metalloproteinase 9; EC 3.4.24.35 / Matrix Metalloproteinase 9; JL5DK93RCL / Melatonin
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80. Olovnikov AM: Hypothesis: lifespan is regulated by chronomere DNA of the hypothalamus. J Alzheimers Dis; 2007 May;11(2):241-52
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  • In adults, this process is under control of the pineal gland.
  • [MeSH-minor] Alzheimer Disease / genetics. Animals. Biological Clocks. Biological Evolution. Chromosome Deletion. Cytoskeleton / genetics. Free Radicals / metabolism. Gravitation. Humans. Lipid Peroxidation / physiology. Moon. Pineal Gland / physiopathology. Pituitary Gland / physiopathology. Werner Syndrome / genetics

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  • (PMID = 17522448.001).
  • [ISSN] 1387-2877
  • [Journal-full-title] Journal of Alzheimer's disease : JAD
  • [ISO-abbreviation] J. Alzheimers Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Free Radicals; 9007-49-2 / DNA
  • [Number-of-references] 63
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81. Pandi-Perumal SR, Zisapel N, Srinivasan V, Cardinali DP: Melatonin and sleep in aging population. Exp Gerontol; 2005 Dec;40(12):911-25
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  • The neurohormone melatonin is released from the pineal gland in close association with the light-dark cycle.
  • This association, as well as the sleep promoting effect of exogenous melatonin, implicates the pineal product in the physiological regulation of sleep.
  • [MeSH-minor] Aged. Alzheimer Disease / complications. Alzheimer Disease / drug therapy. Body Temperature Regulation. Female. Humans. Indenes / therapeutic use. Indoles / therapeutic use. Male. Pineal Gland / secretion. Receptors, Melatonin / agonists. Sleep Wake Disorders / complications. Sleep Wake Disorders / drug therapy

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  • (PMID = 16183237.001).
  • [ISSN] 0531-5565
  • [Journal-full-title] Experimental gerontology
  • [ISO-abbreviation] Exp. Gerontol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Indenes; 0 / Indoles; 0 / LY 156735; 0 / Receptors, Melatonin; 901AS54I69 / ramelteon; JL5DK93RCL / Melatonin
  • [Number-of-references] 232
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82. Bartlett RM, Holden JE, Nickles RJ, Murali D, Barbee DL, Barnhart TE, Christian BT, DeJesus OT: Paraquat is excluded by the blood brain barrier in rhesus macaque: An in vivo pet study. Brain Res; 2009 Mar 9;1259:74-9
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  • The highest concentrations of paraquat were seen in the pineal gland and the lateral ventricles.

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  • [Cites] Crit Rev Toxicol. 2008;38(1):13-71 [18161502.001]
  • [Cites] Exp Neurol. 2007 Nov;208(1):120-6 [17880941.001]
  • [Cites] Clin Toxicol (Phila). 2008 Sep;46(8):768-70 [19238738.001]
  • [Cites] Br J Ind Med. 1966 Apr;23(2):133-6 [5929687.001]
  • [Cites] J Appl Physiol. 1973 Aug;35(2):274-80 [4198712.001]
  • [Cites] Toxicol Appl Pharmacol. 1974 Feb;27(2):283-91 [4212223.001]
  • [Cites] Circ Res. 1975 Dec;37(6):707-14 [811413.001]
  • [Cites] Histopathology. 1980 Mar;4(2):185-95 [7358347.001]
  • [Cites] Science. 1983 Feb 25;219(4587):979-80 [6823561.001]
  • [Cites] Proc Natl Acad Sci U S A. 1985 Apr;82(7):2173-7 [3872460.001]
  • [Cites] Life Sci. 1985 Oct 21;37(16):1529-38 [3876500.001]
  • [Cites] Neurology. 1986 Aug;36(8):1147 [3736891.001]
  • [Cites] Neurotoxicology. 1988 Summer;9(2):243-8 [3205434.001]
  • [Cites] Neurosci Lett. 1988 Oct 31;93(1):1-6 [3264893.001]
  • [Cites] Funct Neurol. 1991 Oct-Dec;6(4):385-91 [1810839.001]
  • [Cites] Funct Neurol. 1992 Jan-Feb;7(1):51-6 [1582580.001]
  • [Cites] Hum Exp Toxicol. 1992 Nov;11(6):535-9 [1361145.001]
  • [Cites] J Chromatogr. 1993 Jul 23;643(1-2):419-25 [8360310.001]
  • [Cites] Hum Exp Toxicol. 1995 Jul;14(7):587-94 [7576819.001]
  • [Cites] Hum Exp Toxicol. 1996 Jul;15(7):583-91 [8818712.001]
  • [Cites] Neurotoxicology. 2005 Jan;26(1):63-75 [15527874.001]
  • [Cites] J Neurochem. 2005 May;93(4):1030-7 [15857406.001]
  • [Cites] Chin Med J (Engl). 2005 Aug 20;118(16):1357-61 [16157030.001]
  • [Cites] Neurobiol Dis. 2007 Feb;25(2):392-400 [17166727.001]
  • [Cites] Brain Res. 2007 Jun 25;1155:196-207 [17493592.001]
  • [Cites] J Neurosci. 2007 Jun 27;27(26):6914-22 [17596439.001]
  • [Cites] Toxicol Sci. 2007 Nov;100(1):1-2 [17934192.001]
  • [Cites] Brain Res. 2001 Jul 6;906(1-2):135-42 [11430870.001]
  • [Cites] J Neurochem. 2003 Apr;85(1):82-6 [12641729.001]
  • [Cites] Toxicol Ind Health. 2002 May;18(4):201-6 [12974543.001]
  • [Cites] Environ Health Perspect. 2007 Oct;115(10):1448-53 [17938734.001]
  • [Cites] J Biol Chem. 2008 Feb 8;283(6):3357-64 [18056701.001]
  • (PMID = 19135428.001).
  • [ISSN] 1872-6240
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA09206; United States / NCI NIH HHS / CA / T32 CA009206; United States / NCI NIH HHS / CA / CA009206-29; United States / NCI NIH HHS / CA / T32 CA009206-28; United States / NCI NIH HHS / CA / T32 CA009206-29; United States / NCI NIH HHS / CA / CA009206-28
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Carbon Radioisotopes; 0 / Neurotoxins; PLG39H7695 / Paraquat
  • [Other-IDs] NLM/ NIHMS108043; NLM/ PMC2700775
  •  go-up   go-down


83. Nakamura K, Hasegawa H: Developmental role of tryptophan hydroxylase in the nervous system. Mol Neurobiol; 2007 Feb;35(1):45-54
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  • TPH2 is abundant in the brain, whereas TPH1 is mainly expressed in the pineal gland and the periphery.
  • An increasing body of evidence suggests the involvement of developmental brain disturbances in psychiatric disorders.

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  • [Cites] Am J Med Genet B Neuropsychiatr Genet. 2004 Jan 1;124B(1):87-91 [14681922.001]
  • [Cites] Biochim Biophys Acta. 1965 Nov 15;111(1):67-78 [5295589.001]
  • [Cites] Trends Neurosci. 1993 Jun;16(6):233-40 [7688165.001]
  • [Cites] Eur J Biochem. 2002 Oct;269(19):4780-8 [12354109.001]
  • [Cites] Arch Gen Psychiatry. 1999 Jan;56(1):98-9 [9892262.001]
  • [Cites] Annu Rev Neurosci. 1999;22:197-217 [10202537.001]
  • [Cites] Arch Biochem Biophys. 1980 Feb;199(2):355-61 [6767445.001]
  • [Cites] Arch Gen Psychiatry. 1999 Jan;56(1):99-101 [9892263.001]
  • [Cites] J Neurochem. 1989 Jun;52(6):1886-91 [2542452.001]
  • [Cites] Psychopharmacology (Berl). 2005 Dec;183(2):257-64 [16220334.001]
  • [Cites] Annu Rev Pharmacol Toxicol. 2003;43:261-84 [12359863.001]
  • [Cites] Biol Psychiatry. 1998 Aug 1;44(3):151-62 [9693387.001]
  • [Cites] FEBS Lett. 1995 Jul 10;368(1):151-4 [7615072.001]
  • [Cites] Arch Gen Psychiatry. 1998 Jan;55(1):33-7 [9435758.001]
  • [Cites] Brain Res Bull. 2001 Nov 15;56(5):413-24 [11750787.001]
  • [Cites] Eur J Biochem. 1982 Feb;122(1):41-7 [7060568.001]
  • [Cites] Nat Rev Neurosci. 2003 Dec;4(12):1002-12 [14618156.001]
  • [Cites] J Neurosci. 1999 Dec 1;19(23):10348-56 [10575032.001]
  • [Cites] FEBS Lett. 1990 Jul 30;268(1):185-8 [2166681.001]
  • [Cites] Biochem Biophys Res Commun. 2005 Dec 9;338(1):277-84 [16185653.001]
  • [Cites] Arch Gen Psychiatry. 1998 Jul;55(7):593-602 [9672049.001]
  • [Cites] Biochem J. 1967 Oct;105(1):351-60 [6056632.001]
  • [Cites] FEBS Lett. 1974 Mar 15;40(1):88-91 [4153102.001]
  • [Cites] Eur J Biochem. 1985 Jun 3;149(2):239-45 [3996408.001]
  • [Cites] Biol Psychiatry. 2003 Aug 15;54(4):465-73 [12915291.001]
  • [Cites] Dev Neurosci. 2003 Mar-Aug;25(2-4):245-56 [12966221.001]
  • [Cites] Eur J Biochem. 1982 Jun;124(3):595-601 [6809461.001]
  • [Cites] Arch Insect Biochem Physiol. 2005 May;59(1):12-31 [15822093.001]
  • [Cites] Adv Exp Med Biol. 1976;74:103-17 [785974.001]
  • [Cites] Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13525-30 [14597720.001]
  • [Cites] J Neurosci. 2005 Sep 7;25(36):8165-72 [16148224.001]
  • [Cites] Protein Expr Purif. 2004 Feb;33(2):185-94 [14711505.001]
  • [Cites] Mol Cell Neurosci. 2000 May;15(5):446-55 [10833301.001]
  • [Cites] J Neurochem. 2005 Jan;92(2):311-20 [15663479.001]
  • [Cites] Proc Natl Acad Sci U S A. 1986 Nov;83(22):8629-33 [2877460.001]
  • [Cites] Brain Res. 1989 Sep 11;497(1):80-5 [2790458.001]
  • [Cites] J Biol Chem. 1970 Apr 10;245(7):1699-709 [5309585.001]
  • [Cites] Mol Psychiatry. 2001 May;6(3):268-73 [11326294.001]
  • [Cites] Trends Neurosci. 1997 Jun;20(6):269-74 [9185309.001]
  • [Cites] J Biol Chem. 1975 Jun 10;250(11):4152-8 [1126946.001]
  • [Cites] J Neurosci. 2001 Feb 1;21(3):884-96 [11157075.001]
  • [Cites] Neuroreport. 1999 Dec 16;10(18):3773-5 [10716208.001]
  • [Cites] Biochim Biophys Acta. 1975 Jul 27;397(1):58-68 [238636.001]
  • [Cites] Am J Psychiatry. 1997 Oct;154(10):1451-3 [9326831.001]
  • [Cites] Am J Med Genet C Semin Med Genet. 2005 Feb 15;133C(1):25-33 [15645480.001]
  • [Cites] Am J Med Genet. 1998 May 8;81(3):245-7 [9603613.001]
  • [Cites] J Neurobiol. 2004 Sep 5;60(3):275-88 [15281067.001]
  • [Cites] Dev Genes Evol. 2002 Feb;212(1):43-6 [11875656.001]
  • [Cites] Schizophr Bull. 2001;27(3):443-55 [11596846.001]
  • [Cites] Mol Psychiatry. 2004 Sep;9(9):879-89 [15052272.001]
  • [Cites] Science. 2004 Jul 9;305(5681):217 [15247473.001]
  • [Cites] J Biochem. 2000 Jan;127(1):121-7 [10731674.001]
  • [Cites] Biochem J. 1987 Dec 1;248(2):501-9 [3435461.001]
  • [Cites] Science. 1967 Jan 13;155(3759):217-9 [6015530.001]
  • [Cites] Trends Neurosci. 1989 Jul;12(7):265-70 [2475939.001]
  • [Cites] Science. 1996 Nov 29;274(5292):1527-31 [8929413.001]
  • [Cites] Science. 2003 Jan 3;299(5603):76 [12511643.001]
  • [Cites] J Neurosci. 2006 Jan 11;26(2):530-4 [16407550.001]
  • [Cites] J Psychiatry Neurosci. 2004 May;29(3):174-84 [15173894.001]
  • (PMID = 17519505.001).
  • [ISSN] 0893-7648
  • [Journal-full-title] Molecular neurobiology
  • [ISO-abbreviation] Mol. Neurobiol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Isoenzymes; 333DO1RDJY / Serotonin; EC 1.14.16.4 / Tryptophan Hydroxylase
  • [Number-of-references] 65
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84. Chowdhury I, Sengupta A, Maitra SK: Melatonin: fifty years of scientific journey from the discovery in bovine pineal gland to delineation of functions in human. Indian J Biochem Biophys; 2008 Oct;45(5):289-304
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  • [Title] Melatonin: fifty years of scientific journey from the discovery in bovine pineal gland to delineation of functions in human.
  • Melatonin (N-acetyl-5-methoxytryptamine) was first purified and characterized from the bovine pineal gland extract by Aron Lerner and co-workers in 1958.
  • Since then, a plethora of information has piled up on its biosynthesis, metabolism, time-bound periodicity, physiological and patho-physiological functions, as well as its interactions with other endocrine or neuro-endocrine organs and tissues in the body.
  • Consistent efforts have uncovered the mystery of this indoleamine, and demonstrated its role in regulation of a large as well as diverse body functions in different groups of animals in general, and in humans in particular.
  • [MeSH-major] Melatonin. Pineal Gland / secretion

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  • (PMID = 19069840.001).
  • [ISSN] 0301-1208
  • [Journal-full-title] Indian journal of biochemistry & biophysics
  • [ISO-abbreviation] Indian J. Biochem. Biophys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] India
  • [Chemical-registry-number] JL5DK93RCL / Melatonin
  • [Number-of-references] 164
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85. Zawilska JB, Berezińska M, Stasikowska O, Lorenc A, Skene DJ, Nowak JZ: Posthatching developmental changes in noradrenaline content in the chicken pineal gland. J Pineal Res; 2005 Mar;38(2):123-9
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  • [Title] Posthatching developmental changes in noradrenaline content in the chicken pineal gland.
  • Noradrenaline (NA) levels in pineal gland of chickens at various posthatching stages (P2, P4, P8, P15, P30 and P57) were determined by high-performance liquid chromatography with electrochemical detection.
  • Pineal NA content markedly increased between P2 and P30.
  • P30 and P57 chickens, kept from the day of hatching under a 12:12 hr light-dark (LD) illumination cycle, exhibited rhythmic changes in pineal NA, with levels in the dark period being markedly higher than in the light period.
  • In younger birds pineal NA concentrations did not show pronounced daily variations.
  • In 4-wk-old chickens (P28-30) kept under constant darkness (DD), the rhythmic pattern of pineal NA persisted for 1 day (with higher values during the subjective dark phase than during the subjective light phase), but this disappeared 24 hr after the introduction of DD.
  • In contrast, NA content in pineal glands isolated from birds maintained for 2 days under continuous light was similar to that found during the light phase of the LD cycle, and did not exhibit significant rhythmicity.
  • In P30 chickens, pretreated with alpha-methyl-p-tyrosine (AMPT, an inhibitor of tyrosine hydroxylase, the key regulatory enzyme in the biosynthesis of catecholamines), pineal NA content declined slowly and monophasically during the light phase.
  • Acute exposure of the dark-adapted P30 and P57 chickens to light significantly decreased pineal NA content, but did not affect pineal NA concentrations in younger birds.
  • Our results suggest that the NA rhythm in the chicken pineal gland and its sensitivity to light regulation progressively develop during the first month of life.
  • [MeSH-major] Aging / metabolism. Chickens / metabolism. Norepinephrine / metabolism. Pineal Gland / metabolism

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  • (PMID = 15683467.001).
  • [ISSN] 0742-3098
  • [Journal-full-title] Journal of pineal research
  • [ISO-abbreviation] J. Pineal Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] X4W3ENH1CV / Norepinephrine
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86. Huang Z, Liu T, Chattoraj A, Ahmed S, Wang MM, Deng J, Sun X, Borjigin J: Posttranslational regulation of TPH1 is responsible for the nightly surge of 5-HT output in the rat pineal gland. J Pineal Res; 2008 Nov;45(4):506-14
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  • [Title] Posttranslational regulation of TPH1 is responsible for the nightly surge of 5-HT output in the rat pineal gland.
  • Serotonin (5-hydroxytryptamine, 5-HT), a precursor for melatonin production, is produced abundantly in the pineal gland of all vertebrate animals.
  • The synthesis of 5-HT in the pineal gland is rate limited by tryptophan hydroxylase 1 (TPH1) whose activity displays a twofold increase at night.
  • Earlier studies from our laboratory demonstrate that pineal 5-HT secretion exhibits dynamic circadian rhythms with elevated levels during the early night, and that the increase is controlled by adrenergic signaling at night.
  • In this study, we report that (a) 5-HT total output from the pineal gland and TPH1 protein levels both display diurnal rhythms with a twofold increase at night;.
  • (c) 5-HT total output and TPH1 protein content in rat pineal gland are both acutely inhibited by light exposure at night.
  • Consistent with these findings, molecular analysis of TPH1 protein revealed that (a) TPH1 is phosphorylated at the serine 58 in vitro and in the night pineal gland; and (b) phosphorylation of TPH1 at this residue is required for cAMP-enhanced TPH1 protein stability.
  • These data support the model that increased nocturnal 5-HT synthesis in the pineal gland is mediated by the phosphorylation of TPH1 at the serine 58, which elevates the TPH1 protein content and activity at night.

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  • [Cites] Science. 2003 Jan 3;299(5603):76 [12511643.001]
  • [Cites] Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4686-91 [11917109.001]
  • [Cites] J Pineal Res. 2003 Sep;35(2):118-24 [12887655.001]
  • [Cites] J Neurochem. 2003 Sep;86(5):1308-11 [12911638.001]
  • [Cites] J Neurochem. 2004 Jul;90(2):442-54 [15228600.001]
  • [Cites] Brain Res. 1977 Dec 16;138(2):364-8 [589481.001]
  • [Cites] J Neurochem. 1978 Oct;31(4):1021-6 [151732.001]
  • [Cites] Proc Natl Acad Sci U S A. 1987 Aug;84(16):5530-4 [3475690.001]
  • [Cites] Mol Cell Endocrinol. 1991 Aug;79(1-3):C153-8 [1936532.001]
  • [Cites] Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6659-63 [8022832.001]
  • [Cites] Life Sci. 1994;55(13):1045-52 [8084209.001]
  • [Cites] Brain Res. 1995 Apr 24;677(2):283-90 [7552254.001]
  • [Cites] J Neurochem. 1996 Jul;67(1):242-50 [8666997.001]
  • [Cites] J Neurochem. 1996 Sep;67(3):917-26 [8752096.001]
  • [Cites] Endocrinology. 1996 Jul;137(7):3033-45 [8770929.001]
  • [Cites] Neurosci Lett. 1996 Jan 5;202(3):185-8 [8848262.001]
  • [Cites] Brain Res Mol Brain Res. 1996 Nov;42(1):25-30 [8915576.001]
  • [Cites] Brain Res. 1996 Oct 28;738(1):1-7 [8949920.001]
  • [Cites] J Neurochem. 1997 May;68(5):2220-3 [9109552.001]
  • [Cites] J Neurochem. 1997 Oct;69(4):1738-45 [9326303.001]
  • [Cites] J Biol Chem. 1997 Oct 17;272(42):26219-25 [9334190.001]
  • [Cites] J Mol Neurosci. 1997 Aug;9(1):35-48 [9356925.001]
  • [Cites] Gen Pharmacol. 1998 Apr;30(4):569-74 [9522177.001]
  • [Cites] J Mol Neurosci. 1998 Jun;10(3):163-79 [9770640.001]
  • [Cites] Annu Rev Pharmacol Toxicol. 1999;39:53-65 [10331076.001]
  • [Cites] J Pineal Res. 2005 Aug;39(1):84-90 [15978062.001]
  • [Cites] J Biol Chem. 2006 Sep 22;281(38):28105-12 [16864580.001]
  • [Cites] J Biol Chem. 2007 Feb 16;282(7):4233-7 [17164235.001]
  • [Cites] Biochem J. 2008 Feb 15;410(1):195-204 [17973628.001]
  • [Cites] J Biol Chem. 2008 May 9;283(19):13216-24 [18339632.001]
  • [Cites] Pharmacol Biochem Behav. 2008 Aug;90(2):148-55 [18045670.001]
  • [Cites] Adv Biosci. 1978 Jul 24-25;21:253-5 [755723.001]
  • [Cites] Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):8083-8 [11427721.001]
  • [Cites] Pharmacol Rev. 2003 Jun;55(2):325-95 [12773631.001]
  • (PMID = 18705647.001).
  • [ISSN] 1600-079X
  • [Journal-full-title] Journal of pineal research
  • [ISO-abbreviation] J. Pineal Res.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / K02 NS054724-03; United States / NINDS NIH HHS / NS / NS057583-03; United States / NINDS NIH HHS / NS / R01 NS057583-03; United States / NINDS NIH HHS / NS / R01 NS057583; United States / NINDS NIH HHS / NS / K02 NS054724; United States / NINDS NIH HHS / NS / NS054724-03
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Messenger; 333DO1RDJY / Serotonin; E0399OZS9N / Cyclic AMP; EC 1.14.16.4 / Tryptophan Hydroxylase; EC 1.14.16.4 / tph1 protein, rat; EC 2.3.1.87 / Aanat protein, rat; EC 2.3.1.87 / Arylalkylamine N-Acetyltransferase; JL5DK93RCL / Melatonin
  • [Other-IDs] NLM/ NIHMS101126; NLM/ PMC2669754
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87. Zawilska JB, Lorenc A, Berezińska M, Vivien-Roels B, Pévet P, Skene DJ: Daily oscillation in melatonin synthesis in the Turkey pineal gland and retina: diurnal and circadian rhythms. Chronobiol Int; 2006;23(1-2):341-50
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  • [Title] Daily oscillation in melatonin synthesis in the Turkey pineal gland and retina: diurnal and circadian rhythms.
  • The aim of the present study was to examine arylalkylamine N-acetyltransferase (AANAT) activity and melatonin content in the pineal gland and retina as well as the melatonin concentration in plasma of the turkey (Meleagris gallopavo), an avian species in which several physiological processes, including reproduction, are controlled by day length.
  • The pineal gland and retina of the turkey rhythmically produced melatonin.
  • In birds kept under a daily LD cycle, melatonin levels in the pineal gland and retina were high during the dark phase and low during the light phase.
  • The pineal and retinal melatonin rhythms mirrored oscillations in the activity of AANAT, the penultimate enzyme in the melatonin biosynthetic pathway.
  • Rhythmic oscillations in AANAT activity in the turkey pineal gland and retina were circadian in nature, as they persisted under conditions of constant darkness (DD).
  • On the sixth day of DD, pineal AANAT activity was still markedly higher during the subjective dark than during the subjective light phase; whereas, AANAT activity in the retina did not exhibit significant oscillations.
  • The results indicate that melatonin rhythmicity in the turkey pineal gland and retina is regulated both by light and the endogenous circadian clock.
  • [MeSH-major] Melatonin / metabolism. Oscillometry. Pineal Gland / anatomy & histology. Retina / anatomy & histology

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  • (PMID = 16687307.001).
  • [ISSN] 0742-0528
  • [Journal-full-title] Chronobiology international
  • [ISO-abbreviation] Chronobiol. Int.
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] JL5DK93RCL / Melatonin
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88. Zilberman-Peled B, Appelbaum L, Vallone D, Foulkes NS, Anava S, Anzulovich A, Coon SL, Klein DC, Falcón J, Ron B, Gothilf Y: Transcriptional regulation of arylalkylamine-N-acetyltransferase-2 gene in the pineal gland of the gilthead seabream. J Neuroendocrinol; 2007 Jan;19(1):46-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transcriptional regulation of arylalkylamine-N-acetyltransferase-2 gene in the pineal gland of the gilthead seabream.
  • Pineal serotonin-N-acetyltransferase (arylalkylamine-N-acetyltransferase; AANAT) is considered the key enzyme in the generation of circulating melatonin rhythms; the rate of melatonin production is determined by AANAT activity.
  • Here, the transcriptional regulation of pineal aanat (aanat2) of the gilthead seabream (Sparus aurata) was investigated.
  • Real-time polymerase chain reaction quantification of aanat2 mRNA levels in the pineal gland collected throughout the 24-h cycle revealed a rhythmic expression pattern.
  • In cultured pineal glands, the amplitude was reduced, but the daily rhythmic expression pattern was maintained under constant illumination, indicating a circadian clock-controlled regulation of seabream aanat2.
  • In vivo transient expression analyses in zebrafish embryos indicated that these promoters contain the necessary elements to drive enhanced expression in the pineal gland.
  • Promoter sequence analyses revealed the presence of the photoreceptor conserved element and an extended E-box (i.e. the binding sites for BMAL/CLOCK and OTX5 that have been previously associated with pineal-specific and rhythmic gene expression).
  • [MeSH-major] Arylalkylamine N-Acetyltransferase / genetics. Gene Expression Regulation, Enzymologic. Pineal Gland / enzymology. Sea Bream / genetics

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  • (PMID = 17184485.001).
  • [ISSN] 0953-8194
  • [Journal-full-title] Journal of neuroendocrinology
  • [ISO-abbreviation] J. Neuroendocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / Otx Transcription Factors; 0 / Trans-Activators; EC 2.3.1.48 / CLOCK Proteins; EC 2.3.1.48 / Clock protein, mouse; EC 2.3.1.87 / Arylalkylamine N-Acetyltransferase
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89. Lecourtier L, Saboureau M, Kelly CD, Pévet P, Kelly PH: Impaired cognitive performance in rats after complete epithalamus lesions, but not after pinealectomy alone. Behav Brain Res; 2005 Jun 20;161(2):276-85
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  • In the midbrain, the epithalamus comprises the habenular nuclei and the pineal gland.
  • Here, the possible involvement of the pineal gland in the same behaviours was assessed, by examining them in two series of experiments.
  • Thus, loss of pineal function causes no deficits in these behaviours and does not alter the qualitative pattern of deficits resulting from habenula damage.
  • [MeSH-major] Brain Diseases / physiopathology. Cognition / physiology. Cognition Disorders / etiology. Epithalamus / physiology. Pineal Gland / physiology

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  • (PMID = 15922054.001).
  • [ISSN] 0166-4328
  • [Journal-full-title] Behavioural brain research
  • [ISO-abbreviation] Behav. Brain Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] EC 2.3.1.6 / Choline O-Acetyltransferase
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90. Gómez-Argüelles JM, Mata P, Bermejo PE, Anciones B: [Worsening of migraine symptoms due to giant pineal cyst apoplexy]. Rev Neurol; 2009 Jan 1-15;48(1):17-9
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  • [Title] [Worsening of migraine symptoms due to giant pineal cyst apoplexy].
  • [Transliterated title] Agravamiento de un cuadro migrañoso por apoplejía de un quiste pineal gigante.
  • INTRODUCTION: Although the association between headaches and pineal gland cysts has been suggested on a number of occasions, no precise evidence of exactly what this relation involves has been produced to date.
  • It is known, however, that a cyst in the pineal gland can bring on or worsen headaches, especially if it is large or there has been bleeding, due to obstructive compromise in the third ventricle and the resulting hydrocephalus that is produced.
  • Magnetic resonance imaging of the brain revealed the presence of a giant cyst in the pineal gland, with a notable amount of blood inside it, which was producing an obstructive hydrocephalus.
  • [MeSH-major] Brain Diseases / complications. Cysts / complications. Hydrocephalus / etiology. Migraine without Aura / complications. Pineal Gland / pathology. Stroke / etiology


91. Sengupta A, Kumar Maitra S: The pineal gland, but not melatonin, is associated with the termination of seasonal testicular activity in an annual reproductive cycle in roseringed parakeet Psittacula krameri. Chronobiol Int; 2006;23(5):915-33
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  • [Title] The pineal gland, but not melatonin, is associated with the termination of seasonal testicular activity in an annual reproductive cycle in roseringed parakeet Psittacula krameri.
  • The role of the pineal gland and its hormone melatonin in the regulation of annual testicular events was investigated for the first time in a psittacine bird, the roseringed parakeet (Psittacula krameri).
  • An analysis of the data reveals that the pineal gland and its hormone melatonin may play an inhibitory role in the development of the testis until the attainment of the seasonal peak in the annual reproductive cycle.
  • However, in all probability, the termination of the seasonal activity of the testis or the initiation of testicular regression in the annual reproductive cycle appears to be the function of the pineal gland, but not of melatonin.
  • [MeSH-major] Pineal Gland / physiology. Reproduction / physiology. Seasons. Testis / metabolism

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  • (PMID = 17050209.001).
  • [ISSN] 0742-0528
  • [Journal-full-title] Chronobiology international
  • [ISO-abbreviation] Chronobiol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 3XMK78S47O / Testosterone; JL5DK93RCL / Melatonin
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92. Lin J, Luo J, Redies C: Differential expression of five members of the ADAM family in the developing chicken brain. Neuroscience; 2008 Nov 19;157(2):360-75
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  • ADAM22 expression is strong in some brain nuclei and in the pineal gland.

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  • (PMID = 18832016.001).
  • [ISSN] 0306-4522
  • [Journal-full-title] Neuroscience
  • [ISO-abbreviation] Neuroscience
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.24.- / ADAM Proteins
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93. Karolczak M, Korf HW, Stehle JH: The rhythm and blues of gene expression in the rodent pineal gland. Endocrine; 2005 Jul;27(2):89-100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The rhythm and blues of gene expression in the rodent pineal gland.
  • In all vertebrates, melatonin is rhythmically synthesized in the pineal gland and functions as a hormonal message, encoding for the duration of night.
  • ICER in turn accumulates only after several hours, a time gap resulting from the required de novo protein synthesis upon adrenergic stimulation.
  • However, these molecular components of neuroendocrine signaling in the rodent pineal gland are supplemented by the impact of a variety of neurotransmitters and neuromodulators, and by translational and post-translational mechanisms.
  • By molecular crosstalk, those different inputs on pinealocytes seem to fine-tune the shape of the melatonin signal, by interacting at various levels with the NE/cAMP/pCREB/ICER pathway.
  • Together, concerted signaling events in the rodent pineal gland help to generate a stable and reliable hormonal message of darkness for the body, that, however, can be altered rapidly upon sudden and unexpected "error" signals.
  • [MeSH-major] Gene Expression / physiology. Melatonin / biosynthesis. Melatonin / genetics. Periodicity. Pineal Gland / physiology. Rodentia / physiology

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  • [Cites] Cell Tissue Res. 2002 Jul;309(1):73-88 [12111538.001]
  • [Cites] Eur J Neurosci. 2004 Jun;19(12):3382-8 [15217395.001]
  • [Cites] Semin Cancer Biol. 1990 Feb;1(1):19-26 [2133107.001]
  • [Cites] Neuroendocrinology. 1996 Apr;63(4):384-92 [8739894.001]
  • [Cites] Eur J Pharmacol. 1999 Oct 21;383(1):75-82 [10556684.001]
  • [Cites] J Biol Chem. 1997 Mar 14;272(11):6979-85 [9054387.001]
  • [Cites] Regul Pept. 1986 Feb;13(3-4):307-18 [3010387.001]
  • [Cites] J Biol Chem. 2005 Apr 29;280(17):16851-60 [15684415.001]
  • [Cites] Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1876-81 [9465110.001]
  • [Cites] Science. 1998 Feb 27;279(5355):1358-60 [9478897.001]
  • [Cites] Endocrinology. 1996 Jul;137(7):3033-45 [8770929.001]
  • [Cites] Brain Res. 1989 May 29;488(1-2):275-82 [2743122.001]
  • [Cites] Mol Cell Biol. 2001 Jun;21(11):3704-13 [11340164.001]
  • [Cites] Eur J Neurosci. 1999 Feb;11(2):725-8 [10051773.001]
  • [Cites] Endocrinology. 1972 Jun;90(6):1470-5 [4401741.001]
  • [Cites] Adv Anat Embryol Cell Biol. 1998;146:1-100 [9670565.001]
  • [Cites] Cell Tissue Res. 1998 Mar;291(3):423-31 [9477299.001]
  • [Cites] Cell Tissue Res. 2002 Jul;309(1):173-82 [12111547.001]
  • [Cites] J Neurosci. 1998 Jul 1;18(13):4946-52 [9634560.001]
  • [Cites] J Neurochem. 1991 Sep;57(3):943-7 [1650397.001]
  • [Cites] Nature. 2002 Aug 29;418(6901):935-41 [12198538.001]
  • [Cites] Arch Oral Biol. 1998 Dec;43(12):933-9 [9877324.001]
  • [Cites] Mol Pharmacol. 1997 Apr;51(4):551-7 [9106618.001]
  • [Cites] J Neurochem. 1997 Jul;69(1):340-7 [9202328.001]
  • [Cites] Cell Tissue Res. 1995 Nov;282(2):219-26 [8565052.001]
  • [Cites] Eur J Endocrinol. 2000 Apr;142(4):387-92 [10754481.001]
  • [Cites] EMBO J. 2002 Sep 2;21(17):4583-92 [12198160.001]
  • [Cites] Adv Exp Med Biol. 1999;460:109-31 [10810507.001]
  • [Cites] J Neural Transm. 1978;42(2):145-9 [206663.001]
  • [Cites] J Pineal Res. 1999 Oct;27(3):170-82 [10535767.001]
  • [Cites] Neurosci Lett. 1996 Jan 5;202(3):185-8 [8848262.001]
  • [Cites] Exp Physiol. 1997 Mar;82(2):237-44 [9129938.001]
  • [Cites] Arch Gen Psychiatry. 2001 Dec;58(12):1108-14 [11735838.001]
  • [Cites] J Neuroendocrinol. 1997 Jul;9(7):537-43 [15305572.001]
  • [Cites] J Physiol. 1997 Mar 1;499 ( Pt 2):329-40 [9080363.001]
  • [Cites] Ciba Found Symp. 1985;117:38-56 [3015512.001]
  • [Cites] J Neurochem. 1992 Dec;59(6):2178-83 [1359017.001]
  • [Cites] Cell Tissue Res. 1985;239(1):81-5 [3967288.001]
  • [Cites] Proc Natl Acad Sci U S A. 2002 May 28;99(11):7728-33 [12032351.001]
  • [Cites] J Neurosci. 2002 Jan 1;22(1):350-6 [11756518.001]
  • [Cites] Neuroreport. 2002 Apr 16;13(5):735-9 [11973480.001]
  • [Cites] Endocrinology. 1985 Jun;116(6):2167-73 [2986940.001]
  • [Cites] Neuroreport. 1995 Jan 26;6(2):345-8 [7756625.001]
  • [Cites] Neurosci Lett. 1986 Oct 8;70(2):187-92 [2430238.001]
  • [Cites] Brain Res. 1994 Apr 18;643(1-2):150-4 [8032911.001]
  • [Cites] BMC Dev Biol. 2001;1:9 [11394964.001]
  • [Cites] Eur J Neurosci. 2000 Mar;12(3):964-72 [10762326.001]
  • [Cites] Am J Physiol Regul Integr Comp Physiol. 2000 May;278(5):R1339-45 [10801305.001]
  • [Cites] J Pineal Res. 1999 Sep;27(2):65-72 [10496141.001]
  • [Cites] J Neural Transm. 1980;48(1):1-8 [7411133.001]
  • [Cites] Neuroscience. 1998 Aug;85(3):887-96 [9639281.001]
  • [Cites] J Pineal Res. 1994 Mar;16(2):57-64 [8014824.001]
  • [Cites] FEBS Lett. 2004 Nov 5;577(1-2):220-6 [15527789.001]
  • [Cites] Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5339-46 [14963227.001]
  • [Cites] Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8734-8 [7568007.001]
  • [Cites] Eur J Neurosci. 1998 Sep;10(9):2896-904 [9758159.001]
  • [Cites] J Neurochem. 2000 Nov;75(5):2123-32 [11032902.001]
  • [Cites] Annu Rev Physiol. 2001;63:647-76 [11181971.001]
  • [Cites] J Neuroendocrinol. 1990 Dec 1;2(6):777-82 [19215418.001]
  • [Cites] J Neuroendocrinol. 2002 Feb;14(2):101-8 [11849369.001]
  • [Cites] Neurosci Lett. 1999 May 21;267(1):69-72 [10400251.001]
  • [Cites] J Pineal Res. 2003 Jan;34(1):11-6 [12485366.001]
  • [Cites] Brain Res. 1997 Nov 28;777(1-2):247-50 [9449437.001]
  • [Cites] J Neurochem. 2000 Jul;75(1):288-97 [10854273.001]
  • [Cites] Nat Neurosci. 2003 Dec;6(12):1255-63 [14625556.001]
  • [Cites] J Pineal Res. 2003 Jan;34(1):53-9 [12485372.001]
  • [Cites] Brain Res. 1994 Jul 18;651(1-2):160-8 [7522930.001]
  • [Cites] J Neurochem. 1998 Jul;71(1):356-65 [9648885.001]
  • [Cites] FEBS Lett. 1998 Oct 2;436(2):169-73 [9781672.001]
  • [Cites] J Neurochem. 2004 Nov;91(4):946-55 [15525348.001]
  • [Cites] Neurosci Lett. 1998 Jun 5;248(3):163-6 [9654334.001]
  • [Cites] Genomics. 1996 May 15;34(1):76-84 [8661026.001]
  • [Cites] Neurochem Int. 1995 Aug;27(2):163-75 [7580872.001]
  • [Cites] Regul Pept. 1996 Jan 16;61(1):63-9 [8701029.001]
  • [Cites] Mol Endocrinol. 1995 Jun;9(6):706-16 [8592516.001]
  • [Cites] J Pineal Res. 1997 Sep;23(2):63-71 [9392444.001]
  • [Cites] Development. 1997 Mar;124(5):1055-67 [9056780.001]
  • [Cites] Histochemistry. 1990;95(1):73-6 [2126785.001]
  • [Cites] Brain Res. 1985 Sep 16;343(1):188-9 [4041854.001]
  • [Cites] J Pineal Res. 2000 Aug;29(1):24-33 [10949537.001]
  • [Cites] J Neurochem. 1996 Feb;66(2):748-55 [8592148.001]
  • [Cites] Eur J Pharmacol. 1997 May 20;326(2-3):229-36 [9196276.001]
  • [Cites] J Pineal Res. 1996 Oct;21(3):165-74 [8981261.001]
  • [Cites] Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14140-5 [8943074.001]
  • [Cites] J Neurochem. 1999 Aug;73(2):598-604 [10428055.001]
  • [Cites] Nat Genet. 2002 Jan;30(1):117-21 [11753388.001]
  • [Cites] Endocrinol Jpn. 1980 Dec;27 Suppl 1:7-10 [6112141.001]
  • [Cites] Curr Biol. 2004 Dec 29;14(24):2289-95 [15620658.001]
  • [Cites] Nature. 1993 Sep 23;365(6444):314-20 [8397338.001]
  • [Cites] Eur J Pharmacol. 1977 Oct 1;45(3):317-8 [200438.001]
  • [Cites] Cell Tissue Res. 1985;242(3):645-8 [2934135.001]
  • [Cites] J Sleep Res. 1995 Dec;4(S2):74-79 [10607217.001]
  • [Cites] Nat Neurosci. 2002 Mar;5(3):234-8 [11836530.001]
  • [Cites] Adv Exp Med Biol. 1999;460:199-214 [10810515.001]
  • [Cites] J Neurosci. 2004 Jun 9;24(23):5346-55 [15190107.001]
  • [Cites] J Comp Neurol. 1989 Jun 1;284(1):135-47 [2754028.001]
  • [Cites] J Neuroendocrinol. 2001 Apr;13(4):313-6 [11264717.001]
  • [Cites] Cell. 1990 Apr 6;61(1):49-59 [2156629.001]
  • [Cites] Cell Tissue Res. 1996 Dec;286(3):305-13 [8929333.001]
  • [Cites] Brain Res Mol Brain Res. 2004 Jan 5;120(2):164-72 [14741406.001]
  • [Cites] Neuroendocrinology. 1998 Jul;68(1):57-63 [9695939.001]
  • [Cites] Brain Res. 1984 May 14;299(2):331-7 [6145495.001]
  • [Cites] Brain Res Mol Brain Res. 1996 Apr;37(1-2):157-65 [8738147.001]
  • [Cites] Brain Res Mol Brain Res. 1992 Nov;16(1-2):111-8 [1334188.001]
  • [Cites] Neurosci Lett. 1997 Mar 21;224(3):173-6 [9131664.001]
  • [Cites] J Neurosci. 1999 May 1;19(9):3326-36 [10212292.001]
  • [Cites] Nat Rev Mol Cell Biol. 2001 Aug;2(8):599-609 [11483993.001]
  • [Cites] Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14884-8 [8962150.001]
  • [Cites] Neurosci Lett. 1987 Feb 24;74(2):158-62 [3574756.001]
  • [Cites] J Neuroendocrinol. 2000 Apr;12(4):287-95 [10718925.001]
  • [Cites] Cell Tissue Res. 1980;205(1):11-7 [6988078.001]
  • [Cites] Cell Tissue Res. 2002 Jul;309(1):109-18 [12111541.001]
  • [Cites] Science. 1995 Dec 8;270(5242):1681-3 [7502081.001]
  • [Cites] Genes Dev. 1994 Nov 1;8(21):2527-39 [7958915.001]
  • [Cites] Nature. 1967 Feb 18;213(5077):730-1 [5298925.001]
  • [Cites] Mol Pharmacol. 1995 Mar;47(3):439-49 [7700241.001]
  • [Cites] J Neurochem. 1992 Aug;59(2):772-5 [1321236.001]
  • [Cites] J Neuroendocrinol. 1995 Mar;7(3):207-14 [7606247.001]
  • [Cites] Brain Res. 1993 Feb 12;603(1):148-52 [8095838.001]
  • [Cites] J Pineal Res. 1996 Apr;20(3):157-63 [8797183.001]
  • [Cites] Neuroendocrinology. 2001 Feb;73(2):111-22 [11244298.001]
  • [Cites] Eur J Neurosci. 2000 Dec;12(12):4557-61 [11122368.001]
  • [Cites] Nature. 1995 Dec 21-28;378(6559):783-5 [8524412.001]
  • [Cites] J Neurochem. 1988 Jan;50(1):149-55 [2447232.001]
  • [Cites] J Neurochem. 1995 May;64(5):2273-80 [7722512.001]
  • [Cites] Cell Tissue Res. 2002 Jul;309(1):151-62 [12111545.001]
  • [Cites] Neurosci Lett. 1993 Jun 25;156(1-2):131-4 [8414175.001]
  • [Cites] Nature. 1999 Mar 4;398(6722):80-4 [10078534.001]
  • [Cites] Cell Tissue Res. 2000 Sep;301(3):369-73 [10994782.001]
  • [Cites] J Neurochem. 1994 Jun;62(6):2464-71 [8189249.001]
  • [Cites] Ophthalmic Res. 1984;16(1-2):88-95 [6728431.001]
  • [Cites] Cell Tissue Res. 2002 Jul;309(1):139-50 [12111544.001]
  • [Cites] Histochemistry. 1991;96(5):401-4 [1660860.001]
  • [Cites] Neurosci Lett. 1990 Oct 30;119(1):12-4 [1982958.001]
  • [Cites] Pharmacol Rev. 2003 Jun;55(2):325-95 [12773631.001]
  • [Cites] Peptides. 1986;7 Suppl 1:193-5 [3018698.001]
  • [Cites] J Pineal Res. 1997 Jan;22(1):33-41 [9062868.001]
  • [Cites] Neurosci Lett. 2000 Jun 9;286(3):167-70 [10832011.001]
  • [Cites] Biol Cell. 1997 Nov;89(8):505-11 [9618900.001]
  • [Cites] Mol Cell Biol. 2000 Dec;20(24):9120-6 [11094064.001]
  • [Cites] Science. 1996 Apr 19;272(5260):419-21 [8602533.001]
  • [Cites] Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):11208-12 [8855334.001]
  • [Cites] J Neurochem. 2003 Apr;85(1):170-9 [12641739.001]
  • [Cites] Nat Genet. 1999 Dec;23(4):466-70 [10581037.001]
  • [Cites] Neuroreport. 1999 May 14;10(7):1599-603 [10380988.001]
  • [Cites] Brain Res Dev Brain Res. 2003 Jul 12;143(2):179-87 [12855189.001]
  • [Cites] Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):8083-8 [11427721.001]
  • [Cites] Cell Tissue Res. 1991 Jul;265(1):63-71 [1680561.001]
  • [Cites] Cell Tissue Res. 1992 Sep;269(3):515-23 [1358453.001]
  • [Cites] Neuron. 2002 Apr 11;34(2):245-53 [11970866.001]
  • [Cites] J Pineal Res. 1996 Oct;21(3):175-91 [8981262.001]
  • [Cites] J Biol Chem. 1988 Jul 5;263(19):9292-7 [2897966.001]
  • [Cites] Mol Pharmacol. 1999 Aug;56(2):279-89 [10419546.001]
  • [Cites] J Biol Chem. 2005 Jan 7;280(1):677-84 [15504733.001]
  • [Cites] J Biol Rhythms. 2001 Aug;16(4):312-25 [11506377.001]
  • [Cites] Nat Rev Mol Cell Biol. 2000 Oct;1(1):59-67 [11413490.001]
  • [Cites] Cell Tissue Res. 2002 Dec;310(3):331-8 [12457232.001]
  • [Cites] Brain Res. 1999 Jun 26;833(1):39-50 [10375675.001]
  • [Cites] Endocrinology. 1992 May;130(5):2804-10 [1315259.001]
  • [Cites] Neuroscience. 1994 Oct;62(4):1267-78 [7845598.001]
  • [Cites] Recent Prog Horm Res. 1997;52:307-57; discussion 357-8 [9238858.001]
  • [Cites] J Biol Chem. 1995 Nov 10;270(45):27319-25 [7592994.001]
  • [Cites] J Neurochem. 2000 Oct;75(4):1398-407 [10987819.001]
  • [Cites] Neurosci Lett. 1991 Feb 11;123(1):131-4 [1829510.001]
  • [Cites] Biochem Mol Biol Int. 1998 Dec;46(6):1127-34 [9891845.001]
  • (PMID = 16217122.001).
  • [ISSN] 1355-008X
  • [Journal-full-title] Endocrine
  • [ISO-abbreviation] Endocrine
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neurotransmitter Agents; JL5DK93RCL / Melatonin
  • [Number-of-references] 166
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94. Guardiola-Lemaitre B: [Melatoninergic receptor agonists and antagonists: therapeutic perspectives]. J Soc Biol; 2007;201(1):105-13
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  • The chronobiotic neurohormone melatonin, synthetized in the pineal gland during darkness periods governs the circadian and seasonal biological rhythms.
  • Physiologically, melatonin regulates the sleep/activity alternance, together with the circadian cycle of body temperature and cortisol secretion, and influences various immune, endocrine and metabolic functions.
  • Dysfunction of the endogenous melatonin secretion is associated with mood and behavioral disorders including body weight.
  • Implication of melatonin in these disorders stimulated the search for melatonin analogues with enhanced antidepressive and body weight control effects.
  • [MeSH-major] Pineal Gland / physiology. Receptors, Melatonin / agonists. Receptors, Melatonin / antagonists & inhibitors
  • [MeSH-minor] Antidepressive Agents / therapeutic use. Body Temperature. Circadian Rhythm. Humans. Melatonin / physiology. Mental Disorders / drug therapy. Mental Disorders / etiology. Mood Disorders / drug therapy. Mood Disorders / etiology. Periodicity

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  • (PMID = 17762830.001).
  • [ISSN] 1295-0661
  • [Journal-full-title] Journal de la Société de biologie
  • [ISO-abbreviation] J. Soc. Biol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antidepressive Agents; 0 / Receptors, Melatonin; JL5DK93RCL / Melatonin
  • [Number-of-references] 57
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95. Djeridane Y, Touitou Y: Lack of effect of ghrelin treatment on melatonin production in rat pineal and Harderian glands. Life Sci; 2005 Apr 1;76(20):2393-401
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  • [Title] Lack of effect of ghrelin treatment on melatonin production in rat pineal and Harderian glands.
  • The aim of the study was to investigate possible ghrelin-melatonin interactions by studying the effect of ghrelin treatment on melatonin production in rat pineal and Harderian glands.
  • Neither ghrelin doses (1 microg/rat or 15 microg/rat) nor type of treatment (acute or repeated) influenced melatonin levels or the melatonin synthesizing enzymes N-acetyltransferase and hydroxyindole-O-methyltransferase activities, either in pineal gland or in Harderian glands.
  • At the concentrations used, ghrelin does not influence melatonin production in rat pineal and Harderian glands, and therefore is not involved in the regulation of melatonin secretion, at least under our experimental conditions.
  • [MeSH-major] Harderian Gland / metabolism. Melatonin / biosynthesis. Peptide Hormones / administration & dosage. Pineal Gland / metabolism

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  • (PMID = 15748632.001).
  • [ISSN] 0024-3205
  • [Journal-full-title] Life sciences
  • [ISO-abbreviation] Life Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Ghrelin; 0 / Peptide Hormones; EC 2.1.1.4 / Acetylserotonin O-Methyltransferase; EC 2.3.1.- / Acetyltransferases; JL5DK93RCL / Melatonin
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96. Srinivasan V, Spence DW, Trakht I, Pandi-Perumal SR, Cardinali DP, Maestroni GJ: Immunomodulation by melatonin: its significance for seasonally occurring diseases. Neuroimmunomodulation; 2008;15(2):93-101
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  • Melatonin is not only synthesized by the pineal gland but also in many other organs and tissues of the body, particularly by lymphoid organs such as the bone marrow, thymus and lymphocytes.
  • Melatonin participates in various functions of the body, among which its immunomodulatory role has assumed considerable significance in recent years.
  • Moreover, melatonin-induced seasonal changes in immune function have also been implicated in the pathogenesis of seasonal affective disorder and rheumatoid arthritis.
  • [MeSH-minor] Animals. Arthritis, Rheumatoid / immunology. Cytokines / metabolism. Cytokines / physiology. Cytokines / secretion. Humans. Seasonal Affective Disorder / immunology. T-Lymphocytes / immunology. T-Lymphocytes / metabolism. T-Lymphocytes / secretion

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  • [Copyright] (c) 2008 S. Karger AG, Basel.
  • (PMID = 18679047.001).
  • [ISSN] 1423-0216
  • [Journal-full-title] Neuroimmunomodulation
  • [ISO-abbreviation] Neuroimmunomodulation
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Cytokines; 0 / Immunologic Factors; JL5DK93RCL / Melatonin
  • [Number-of-references] 103
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97. Alon S, Eisenberg E, Jacob-Hirsch J, Rechavi G, Vatine G, Toyama R, Coon SL, Klein DC, Gothilf Y: A new cis-acting regulatory element driving gene expression in the zebrafish pineal gland. Bioinformatics; 2009 Mar 1;25(5):559-62
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  • [Title] A new cis-acting regulatory element driving gene expression in the zebrafish pineal gland.
  • RESULTS: Here we report in silico identification and in vivo validation of regulatory elements that determine enhanced gene expression in the pineal gland of zebrafish.
  • Microarray data enabled detection of genes that exhibit high expression in the pineal gland.
  • The highest ranking motif identified is a CRX/OTX binding site, known to govern expression in the pineal gland and retina.
  • [MeSH-major] Computational Biology / methods. Gene Expression Regulation. Pineal Gland / metabolism. Regulatory Elements, Transcriptional. Zebrafish / genetics

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  • (PMID = 19147662.001).
  • [ISSN] 1367-4811
  • [Journal-full-title] Bioinformatics (Oxford, England)
  • [ISO-abbreviation] Bioinformatics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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98. Mazzoccoli G, Vendemiale G, De Cata A, Carughi S, Tarquini R: Altered time structure of neuro-endocrine-immune system function in lung cancer patients. BMC Cancer; 2010;10:314
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  • The nervous, endocrine and immune system might act as an integrated unit to maintain body defense against this pathological process and reciprocal influences have been evidenced among hypothalamus, pituitary, thyroid, adrenal, pineal gland and immune system.
  • [MeSH-major] Circadian Rhythm / physiology. Endocrine System / physiopathology. Immune System / physiopathology. Lung Neoplasms / physiopathology. Neurosecretory Systems / physiopathology

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  • [Cites] Biol Signals Recept. 2000 Sep-Oct;9(5):215-30 [10965056.001]
  • [Cites] Eur J Endocrinol. 1995 Dec;133(6):635-45 [8548046.001]
  • [Cites] Cancer Immunol Immunother. 2000 Dec;49(10):530-6 [11129323.001]
  • [Cites] Neuro Endocrinol Lett. 2003 Feb-Apr;24(1-2):77-82 [12743538.001]
  • [Cites] Int J Immunopathol Pharmacol. 2003 May-Aug;16(2):167-74 [12797908.001]
  • [Cites] Surgery. 1973 Jan;73(1):102-8 [4566775.001]
  • [Cites] Immunology. 1975 Apr;28(4):669-80 [1080130.001]
  • [Cites] Br Med J. 1979 Jan 13;1(6156):75-7 [367500.001]
  • [Cites] Clin Exp Immunol. 1978 Sep;33(3):441-52 [310741.001]
  • [Cites] Chronobiologia. 1979 Oct-Dec;6(4):305-23 [548245.001]
  • [Cites] Nature. 1980 Jun 26;285(5767):662-4 [6446684.001]
  • [Cites] Neuroendocrinology. 1983;36(1):68-78 [6338409.001]
  • [Cites] J Neuroimmunol. 1986 Nov;13(1):19-30 [2944914.001]
  • [Cites] Ann N Y Acad Sci. 1987;496:67-77 [3474997.001]
  • [Cites] J Pineal Res. 1988;5(3):317-22 [3404401.001]
  • [Cites] Cancer. 1989 Jun 1;63(11):2139-47 [2541884.001]
  • [Cites] Cancer Res. 1989 Dec 15;49(24 Pt 1):7002-9 [2555057.001]
  • [Cites] J Neuroimmunol. 1990 May;27(2-3):99-109 [2159021.001]
  • [Cites] J Neuroimmunol. 1990 Jul;28(2):167-76 [1972943.001]
  • [Cites] Chronobiol Int. 1990;7(3):259-61 [2268888.001]
  • [Cites] Surg Today. 1992;22(1):35-9 [1547372.001]
  • [Cites] Oncology. 1992;49(2):108-13 [1574245.001]
  • [Cites] Clin Chim Acta. 1992 Aug 31;209(3):153-67 [1395046.001]
  • [Cites] J Clin Endocrinol Metab. 1993 Jun;76(6):1610-6 [7684744.001]
  • [Cites] Chronobiologia. 1993 Jan-Jun;20(1-2):1-52 [8354098.001]
  • [Cites] Gut. 1996 Jan;38(1):85-9 [8566865.001]
  • [Cites] Adv Cancer Res. 1996;68:183-223 [8712068.001]
  • [Cites] Cancer Immunol Immunother. 1996 Jul;42(6):339-42 [8830736.001]
  • [Cites] N Engl J Med. 1997 Jan 16;336(3):186-95 [8988899.001]
  • [Cites] Endocr Rev. 1997 Apr;18(2):157-79 [9101135.001]
  • [Cites] J Pineal Res. 1997 Sep;23(2):53-8 [9392442.001]
  • [Cites] J Biol Regul Homeost Agents. 1997 Oct-Dec;11(4):143-7 [9582614.001]
  • [Cites] Recenti Prog Med. 1998 Nov;89(11):569-72 [9844441.001]
  • [Cites] Anticancer Res. 1999 Mar-Apr;19(2B):1397-9 [10365112.001]
  • [Cites] J Steroid Biochem Mol Biol. 1999 Mar;68(5-6):181-7 [10416832.001]
  • [Cites] In Vivo. 1999 May-Jun;13(3):205-9 [10459492.001]
  • [Cites] FASEB J. 1999 Sep;13(12):1547-56 [10463946.001]
  • [Cites] Neuro Endocrinol Lett. 2004 Oct;25(5):368-72 [15580172.001]
  • [Cites] Med Sci Monit. 2005 Jun;11(6):CR284-288 [15917719.001]
  • [Cites] Am J Physiol Gastrointest Liver Physiol. 2005 Aug;289(2):G227-39 [15831712.001]
  • [Cites] Cancer Res. 2007 Jan 1;67(1):5-8 [17210676.001]
  • [Cites] Redox Rep. 2008;13(2):78-86 [18339250.001]
  • [Cites] J Pineal Res. 2007 Oct;43(3):305-12 [17803529.001]
  • [Cites] Int J Neurosci. 1992 Jan;62(1-2):141-53 [1342010.001]
  • [Cites] J Pineal Res. 1995 Mar;18(2):84-9 [7629695.001]
  • [Cites] Front Neuroendocrinol. 1995 Oct;16(4):383-415 [8557171.001]
  • [Cites] Growth Horm IGF Res. 2000 Apr;10 Suppl B:S9-14 [10984247.001]
  • (PMID = 20565977.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2910689
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99. Turkistani A, Abdullah KM, Al-Shaer AA, Mazen KF, Alkatheri K: Melatonin premedication and the induction dose of propofol. Eur J Anaesthesiol; 2007 May;24(5):399-402
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  • BACKGROUND AND OBJECTIVES: Melatonin (N-acetyl-5-methoxytryptamine) is the main indolamine secreted by the pineal gland.

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  • (PMID = 17094871.001).
  • [ISSN] 0265-0215
  • [Journal-full-title] European journal of anaesthesiology
  • [ISO-abbreviation] Eur J Anaesthesiol
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Hypnotics and Sedatives; JL5DK93RCL / Melatonin; YI7VU623SF / Propofol
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100. Gilheeney SW, Saad A, Chi S, Turner C, Ullrich NJ, Goumnerova L, Scott RM, Marcus K, Lehman L, De Girolami U, Kieran MW: Outcome of pediatric pineoblastoma after surgery, radiation and chemotherapy. J Neurooncol; 2008 Aug;89(1):89-95
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  • INTRODUCTION: Pineoblastomas are a category of supratentorial primitive neuroectodermal tumors (sPNETs) occurring in the pineal gland; some studies support the impression that patients with pineoblastomas have a worse prognosis than those with other sPNETs.
  • METHODS: We reviewed the medical records and tissue sections of all patients with the diagnosis of pineoblastoma that were treated at the Dana-Farber Cancer Institute/Children's Hospital Boston Pediatric Brain Tumor Program between 1986 and 2005.
  • RESULTS: Thirteen patients with the pathologic diagnosis of pineoblastoma were treated at our Hospital; 11 of these cases had complete records suitable for study.
  • [MeSH-major] Pineal Gland / pathology. Pinealoma

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  • [Cites] Childs Nerv Syst. 2006 Jun;22(6):577-85 [16555075.001]
  • [Cites] Childs Nerv Syst. 1999 Oct;15(10):586-91 [10550590.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1998 Dec 1;42(5):959-67 [9869216.001]
  • [Cites] Acta Neuropathol. 2006 Jul;112(1):5-12 [16685513.001]
  • [Cites] J Clin Oncol. 1995 Jul;13(7):1687-96 [7602359.001]
  • [Cites] J Clin Oncol. 1995 Jun;13(6):1377-83 [7751882.001]
  • [Cites] Clin Cancer Res. 2004 Aug 15;10 (16):5482-93 [15328187.001]
  • [Cites] J Clin Oncol. 2004 Mar 15;22(6):994-8 [14970184.001]
  • [Cites] Cancer. 2002 Jan 15;94(2):552-60 [11900240.001]
  • [Cites] Neurol Clin. 2003 Nov;21(4):897-913 [14743655.001]
  • [Cites] J Clin Oncol. 1997 May;15(5):1814-23 [9164190.001]
  • [Cites] Neurosurg Focus. 2005 Nov 15;19(5):E3 [16398467.001]
  • [Cites] Med Pediatr Oncol. 2002 Sep;39(3):168-74 [12210445.001]
  • [Cites] Am J Surg Pathol. 2004 May;28(5):644-50 [15105654.001]
  • [Cites] Cancer Genet Cytogenet. 2006 Oct 15;170(2):175-9 [17011992.001]
  • [Cites] Pediatr Blood Cancer. 2004 Mar;42(3):261-7 [14752864.001]
  • [Cites] Med Pediatr Oncol. 1995 Jul;25(1):38-44 [7753001.001]
  • [Cites] J Clin Oncol. 2005 Oct 20;23(30):7621-31 [16234523.001]
  • [Cites] Neuro Oncol. 1999 Apr;1(2):152-61 [11554387.001]
  • [Cites] J Clin Oncol. 2003 Jun 1;21(11):2187-91 [12775745.001]
  • [Cites] Cancer. 2000 May 1;88(9):2189-93 [10813733.001]
  • [Cites] J Neuropathol Exp Neurol. 2005 May;64(5):391-7 [15892296.001]
  • [Cites] J Neurooncol. 2007 Jan;81(2):217-23 [16941074.001]
  • [Cites] J Clin Oncol. 2004 Mar 15;22(6):984-93 [