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Items 1 to 73 of about 73
1. Joshi D, Gangane N, Kishore S, Vagha S: Unusual histological presentation in neurofibromas: Two case reports. Cases J; 2008;1(1):188

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histological examination of case no.1 revealed a benign tumor of the peripheral nerve sheath, of neurofibroma type with presence of mucus producing glands.
  • The epithelial component was benign in this case.

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  • [Cites] Arch Pathol Lab Med. 2000 Sep;124(9):1364-8 [10975940.001]
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  • (PMID = 18823533.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2565668
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2. Yoo KH, Kim BJ, Rho YK, Lee JW, Kim YJ, Kim MN, Song KY: A case of diffuse neurofibroma of the scalp. Ann Dermatol; 2009 Feb;21(1):46-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A neurofibroma is a benign tumor of the peripheral nerve sheath characterized by proliferation of Schwann cells, perineural cells, and endoneurial fibroblasts.

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  • [Cites] Histopathology. 1988 Aug;13(2):181-9 [3169686.001]
  • [Cites] Am J Dermatopathol. 1994 Oct;16(5):486-95 [7528474.001]
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  • (PMID = 20548855.001).
  • [ISSN] 2005-3894
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2883368
  • [Keywords] NOTNLM ; Diffuse neurofibroma / Scalp
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3. Patil K, Mahima VG, Shetty SK, Lahari K: Facial plexiform neurofibroma in a child with neurofibromatosis type I: a case report. J Indian Soc Pedod Prev Dent; 2007 Mar;25(1):30-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Plexiform neurofibroma is a non-circumscribed, thick and irregular benign tumor of the peripheral nerve sheath.
  • [MeSH-major] Facial Neoplasms. Neurofibroma, Plexiform. Neurofibromatosis 1 / complications

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  • (PMID = 17456965.001).
  • [ISSN] 0970-4388
  • [Journal-full-title] Journal of the Indian Society of Pedodontics and Preventive Dentistry
  • [ISO-abbreviation] J Indian Soc Pedod Prev Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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4. Di Giovanni A, Parente P, Colli R: Recurrent plexiform schwannoma in vestibular mucosa. G Chir; 2006 Mar;27(3):105-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Schwannoma, also called neurilemmoma, is a benign neoplasm of peripheral nerve sheath.
  • An infrequent location of a multiple intraoral plexiform schwannoma arising on the branches of the facial nerve in the vestibular mucosa of a young male patient is here discussed.
  • [MeSH-major] Mouth Mucosa / pathology. Mouth Neoplasms. Neoplasm Recurrence, Local. Neurilemmoma

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  • (PMID = 16681871.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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5. Aguirre-Quezada DE, Martínez-Anda JJ, Aguilar-Ayala EL, Chávez-Macías L, Olvera-Rabiela JE: [Intracranial and intramedullary peripheral nerve sheath tumours. Case reports from 20 autopsies]. Rev Neurol; 2006 Aug 16-31;43(4):197-200
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Intracranial and intramedullary peripheral nerve sheath tumours. Case reports from 20 autopsies].
  • [Transliterated title] Tumores de vaina de nervio periférico intracraneales e intrarraquídeos. Informe de 20 casos de autopsia.
  • INTRODUCTION: Tumors arising from the sheath of peripheral nerves, both intracranial and intraspinal, are uncommon and are sometimes of difficult clinical diagnosis, especially when they occur in unusual sites.
  • Histological malignancy of this neoplasm is rare.
  • MATERIALS AND METHODS: The clinical and pathological findings of 20 autopsy cases of intracranial and intraspinal peripheral nerve tumors are analyzed.
  • RESULTS: 19 were schwannomas, 13 of the 8th cranial nerve (two associated with neurofibromatosis type 2), two originated in the trigeminal and one in the 12th nerves.
  • The importance of early detection on intracranial and intraspinal peripheral tumors is paramount, since the large size of these histologically benign neoplasms makes them biologically malignant.
  • [MeSH-major] Brain Neoplasms / pathology. Cranial Nerve Neoplasms / pathology. Nerve Sheath Neoplasms / pathology. Spinal Cord Neoplasms / pathology

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  • (PMID = 16883507.001).
  • [ISSN] 0210-0010
  • [Journal-full-title] Revista de neurologia
  • [ISO-abbreviation] Rev Neurol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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6. Kozakiewicz J, Włoczyk ES, Wolańska-Karut J: [A rare case of schwannoma in the parotid gland]. Otolaryngol Pol; 2005;59(3):449-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The authors described that rare benign neoplasm of peripheral nerve sheath, localized in parotid gland in a 68-year-old female.
  • [MeSH-major] Neurilemmoma. Parotid Neoplasms

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  • (PMID = 16117408.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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7. Kumar BS, Gopal M, Talwar A, Ramesh M: Diffuse neurofibroma of the scalp presenting as circumscribed alopecic patch. Int J Trichology; 2010 Jan;2(1):60-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neurofibroma is a benign tumor of the peripheral nerve sheath characterized by proliferation of Schwann cells, perineural cells and endoneurial fibroblasts.

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  • (PMID = 21188030.001).
  • [ISSN] 0974-9241
  • [Journal-full-title] International journal of trichology
  • [ISO-abbreviation] Int J Trichology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3002418
  • [Keywords] NOTNLM ; Alopecia Areata / diffuse neurofibroma / scalp
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8. Dimitrakopoulos I, Lasaridis N, Asimaki A: Primary malignant peripheral nerve sheath tumour in the temporalis muscle. J Craniomaxillofac Surg; 2008 Jul;36(5):300-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary malignant peripheral nerve sheath tumour in the temporalis muscle.
  • INTRODUCTION: Primary malignant neoplasms of nerve sheath origin are rare, highly aggressive tumours that account for no more than 5% of all soft tissue sarcomas.
  • In the head and neck where the great majority of peripheral nerve neoplasms are benign, as in the rest of the body, malignant peripheral nerve sheath tumours (MPNSTs) are unusual lesions.
  • DISCUSSION: The clinicopathologic properties of this neoplasm have been widely discussed and the emphasis is on the need for its early identification since the tumour's non-specific symptoms may result in delayed diagnosis and treatment.
  • The rarity of the tumour along with its clinical appearance and the vague symptoms may result in delayed referral and thus the tumour being quite large when diagnosed.
  • [MeSH-major] Muscle Neoplasms / pathology. Nerve Sheath Neoplasms / pathology. Temporal Muscle / pathology
  • [MeSH-minor] Aged. Fatal Outcome. Humans. Male. Neoplasm Recurrence, Local / surgery

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  • (PMID = 18367405.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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9. Tucker T, Wolkenstein P, Revuz J, Zeller J, Friedman JM: Association between benign and malignant peripheral nerve sheath tumors in NF1. Neurology; 2005 Jul 26;65(2):205-11

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association between benign and malignant peripheral nerve sheath tumors in NF1.
  • OBJECTIVE: People with neurofibromatosis type 1 (NF1) have a 10% lifetime risk of developing a malignant peripheral nerve sheath tumor (MPNST).
  • However, it is not known whether an individual's risk of developing an MPNST is associated with the burden of benign neurofibromas.
  • The authors conducted a study to determine whether people with NF1 who have benign neurofibromas of various kinds are at greater risk of developing MPNSTs than patients with NF1 who lack these benign tumors.
  • CONCLUSIONS: The observation that malignant peripheral nerve sheath tumors are strongly associated with internal plexiform neurofibromas suggests that patients with neurofibromatosis type 1 with these benign tumors warrant increased surveillance for malignancy.
  • [MeSH-major] Nerve Sheath Neoplasms / epidemiology. Neurofibroma, Plexiform / epidemiology. Neurofibromatosis 1 / epidemiology. Peripheral Nerves / pathology
  • [MeSH-minor] Adolescent. Adult. Comorbidity. Cross-Sectional Studies. Female. Follow-Up Studies. Humans. Life Expectancy. Logistic Models. Male. Middle Aged. Neoplasm Metastasis / pathology. Neoplasm Metastasis / physiopathology. Prevalence. Prognosis. Risk Factors. Survival Rate. Tomography, X-Ray Computed / adverse effects. Tomography, X-Ray Computed / standards. Ultrasonography / standards

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  • (PMID = 16043787.001).
  • [ISSN] 1526-632X
  • [Journal-full-title] Neurology
  • [ISO-abbreviation] Neurology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. López-Jornet P, Gomez-Garcia E, Camacho-Alonso F: Solitary oral neurofibroma. N Y State Dent J; 2010 Aug-Sep;76(5):54-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neurofibroma is a benign tumor of the peripheral nerve sheath characterized by proliferation of Schwann's cells, perineural cells and endoneurial fibroblasts.
  • The tumor occurs most often in the head and neck regions.
  • [MeSH-major] Lip Neoplasms / diagnosis. Neurofibroma / diagnosis

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  • (PMID = 21053645.001).
  • [ISSN] 0028-7571
  • [Journal-full-title] The New York state dental journal
  • [ISO-abbreviation] N Y State Dent J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Laskin WB, Fetsch JF, Lasota J, Miettinen M: Benign epithelioid peripheral nerve sheath tumors of the soft tissues: clinicopathologic spectrum of 33 cases. Am J Surg Pathol; 2005 Jan;29(1):39-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign epithelioid peripheral nerve sheath tumors of the soft tissues: clinicopathologic spectrum of 33 cases.
  • Benign epithelioid peripheral nerve sheath tumors (BEPNSTs) have not been fully characterized, and their relationship to conventional schwannoma and neurofibroma has not been satisfactorily established.
  • Tumors consisted of trabeculae, loosely arranged nodules, and cohesive nests of epithelioid tumor cells immersed in collagenous, myxohyaline, or chiefly myxoid stroma.
  • A bland spindled cell component comprising 5% to 40% of the tumor was noted in 15 cases.
  • Immunohistochemical reactivity for Schwann cell-related markers in tumor cells included S-100 protein (20 of 20 cases), collagen type IV (10 of 10), laminin (8 of 8), nerve growth factor receptor, p75(7 of 8), CD57 (6 of 9), and glial fibrillary acidic protein (8 of 15).
  • CD34-positive fibroblast-like cells were identified in all 12 neoplasms tested.
  • Follow-up for 18 patients (median interval, 13.5 years), including 4 patients with tumors exhibiting cytologic atypia, revealed a nondestructive recurrence or persistent disease in 3 patients whose tumors lacked atypia, but no evidence of metastatic spread or tumor-related death.
  • BEPNSTs are usually small neoplasms located in superficial soft tissue and have an excellent prognosis after complete local excision.
  • [MeSH-major] Epithelioid Cells / pathology. Nerve Sheath Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Child. Child, Preschool. DNA, Neoplasm / analysis. Female. Humans. Immunoenzyme Techniques. Loss of Heterozygosity. Male. Middle Aged. Mitotic Index. Neurofibromin 1 / genetics. Neurofibromin 1 / metabolism. Neurofibromin 2 / genetics. Neurofibromin 2 / metabolism. Polymerase Chain Reaction

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  • (PMID = 15613855.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Neurofibromin 1; 0 / Neurofibromin 2
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12. Macarenco RS, Ellinger F, Oliveira AM: Perineurioma: a distinctive and underrecognized peripheral nerve sheath neoplasm. Arch Pathol Lab Med; 2007 Apr;131(4):625-36
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Perineurioma: a distinctive and underrecognized peripheral nerve sheath neoplasm.
  • CONTEXT: Perineuriomas are benign peripheral nerve sheath neoplasms composed of perineurial cells with characteristic immunohistochemical and ultrastructural features.
  • Cytogenetic and molecular genetic studies are still of limited value for the diagnosis of perineuriomas but may play a fundamental role in excluding important differential diagnoses and also in helping elucidate the biology of these poorly known neoplasms.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Microscopy, Electron. Prognosis

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  • (PMID = 17425397.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 74
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13. Sturgeon BP, Milne EM, Smith KC: Benign peripheral nerve sheath tumor of the perianal region in a young pony. J Vet Diagn Invest; 2008 Jan;20(1):93-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign peripheral nerve sheath tumor of the perianal region in a young pony.
  • On the basis of the histopathology and immunohistochemistry, a diagnosis of benign peripheral nerve sheath tumor (schwannoma type) was made.
  • This case was unusual in that the concentric laminations of Schwann cells were very loosely arranged, with an intervening myxomatous stroma (Antoni type B appearance) and despite its benign histological appearance, the mass extended deeply to the proximal sacral vertebrae.
  • [MeSH-major] Anus Neoplasms / veterinary. Horse Diseases / pathology. Nerve Sheath Neoplasms / veterinary
  • [MeSH-minor] Animals. Horses. Immunohistochemistry / veterinary. Male. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / veterinary

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  • (PMID = 18182519.001).
  • [ISSN] 1040-6387
  • [Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • [ISO-abbreviation] J. Vet. Diagn. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Nah YW, Suh JH, Choi DH, Ko BK, Nam CW, Kim GY, Im YC, Cho HR: Benign retroperitoneal schwannoma: surgical consideration. Hepatogastroenterology; 2005 Nov-Dec;52(66):1681-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign retroperitoneal schwannoma: surgical consideration.
  • Schwannoma, which arises from the neural sheath of peripheral nerves, is the most common benign tumor in the retroperitoneum in adults.
  • During surgery, it seems to be unnecessary to identify the small peripheral nerve from which it develops.
  • There are few vessels, if any, on the anterior and lateral surfaces of the tumor.
  • In conclusion, considering such multiple small tumor vessels running adjacent to the aorta, the surgeon should pay close attention to the course of central dissection of these tumors in the retroperitoneum.
  • [MeSH-major] Neurilemmoma / pathology. Neurilemmoma / surgery. Retroperitoneal Neoplasms / pathology. Retroperitoneal Neoplasms / surgery
  • [MeSH-minor] Adult. Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Korea. Laparoscopy / methods. Laparotomy / methods. Middle Aged. Neoplasm Staging. Retrospective Studies. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome. Ultrasonography, Doppler

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  • (PMID = 16334756.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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15. Rafai MA, El Otmani H, Rafai M, Bouhaajaj FZ, Largab A, Trafeh M, Adil A, Kadiri R, Slassi I: [Peroneal nerve schwannoma presenting with a peroneal palsy]. Rev Neurol (Paris); 2006 Sep;162(8-9):866-8
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  • [Title] [Peroneal nerve schwannoma presenting with a peroneal palsy].
  • [Transliterated title] Syndrome de paralysie péronière révélant un schwannome du sciatique poplité externe au col du péroné
  • Peroneal nerve injury in the lateral aspect of the knee is frequent, commonly dominated by traumatic or compressive etiologies.
  • Schwannoma is the most frequent peripheral nerve benign tumor.
  • Localization on the lower limbs (sciatic nerve) has been reported in 1 percent of cases.
  • The peroneal nerve localizaton has not been reported to date.
  • [MeSH-major] Neurilemmoma / diagnosis. Paralysis / epidemiology. Peripheral Nervous System Neoplasms / diagnosis. Peroneal Neuropathies / etiology
  • [MeSH-minor] Aged. Female. Humans. Sciatic Nerve / physiopathology. Treatment Outcome

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  • (PMID = 17028550.001).
  • [ISSN] 0035-3787
  • [Journal-full-title] Revue neurologique
  • [ISO-abbreviation] Rev. Neurol. (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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16. Nascimento AF, Fletcher CD: The controversial nosology of benign nerve sheath tumors: neurofilament protein staining demonstrates intratumoral axons in many sporadic schwannomas. Am J Surg Pathol; 2007 Sep;31(9):1363-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The controversial nosology of benign nerve sheath tumors: neurofilament protein staining demonstrates intratumoral axons in many sporadic schwannomas.
  • Schwannomas are benign peripheral nerve sheath tumors believed to be composed purely of cells with ultrastructural features of Schwann cells; these tumors are believed to develop eccentrically from the surface of nerves and not to contain axons, other than immediately beneath the capsule.
  • The amount (rare, focal, multifocal, and diffuse) and distribution (central and/or peripheral) of axons within the tumors were analyzed.
  • NFP-positive axons were identified in 11 of 20 (55%) conventional schwannomas (2 rare, 4 focal, 3 multifocal, and 2 diffuse; 5 central, 4 peripheral, and 2 central and peripheral) and in 15 of 20 (75%) cellular schwannomas (3 rare, 6 focal, and 6 multifocal; 12 central, 1 peripheral, and 2 central and peripheral).
  • Of the 20 ancient schwannomas, 7 cases (35%) showed intratumoral axons, highlighted by NFP immunostaining (1 rare, 4 focal, 1 multifocal, and 1 diffuse; 4 peripheral, 2 central, and 1 central and peripheral).
  • The unexpected but quite frequent presence of intratumoral axons in schwannomas argues against conventional views of these lesions' pathogenesis as an eccentric encapsulated lesion and raises the possibility that a more diverse cell population, perhaps more closely resembling neurofibromas, may constitute these neoplasms.
  • Differentiation between neurofibroma and schwannoma in cases with overlapping cytoarchitectural features should not be based solely on the presence or absence of NFP-positive axons within a given tumor.
  • [MeSH-major] Axons / chemistry. Neurilemmoma / diagnosis. Neurofibroma / diagnosis. Neurofilament Proteins / analysis. S100 Proteins / analysis. Schwann Cells / chemistry. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Cell Differentiation. Cell Proliferation. Diagnosis, Differential. Humans. Immunohistochemistry. Neoplasm Invasiveness. Predictive Value of Tests. Reproducibility of Results

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  • (PMID = 17721192.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neurofilament Proteins; 0 / S100 Proteins
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17. Paolini S, Raco A, Di Stefano D, Esposito V, Ciappetta P: Post-radiation intramedullary malignant peripheral nerve sheath tumor. J Neurosurg Sci; 2006 Jun;50(2):49-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Post-radiation intramedullary malignant peripheral nerve sheath tumor.
  • We report the intramedullary growth of a malignant peripheral nerve sheath tumour (MPNST).
  • A friable neoplasm, with no clear plane of cleavage, was found.
  • The tumour was subtotally resected.
  • MPNSTs may develop within the spinal cord similarly to their benign schwannian counterpart.
  • [MeSH-major] Neoplasms, Radiation-Induced / diagnosis. Nerve Sheath Neoplasms / etiology. Spinal Cord Neoplasms / etiology

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  • (PMID = 16841028.001).
  • [ISSN] 0390-5616
  • [Journal-full-title] Journal of neurosurgical sciences
  • [ISO-abbreviation] J Neurosurg Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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18. Socolovsky M, Spaho N, Cueto DG, Doglietto F, Fernandez E: Reactive lymphoid follicular hyperplasia mimicking a peripheral nerve tumor. Surg Neurol; 2008 Nov;70(5):514-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reactive lymphoid follicular hyperplasia mimicking a peripheral nerve tumor.
  • BACKGROUND: Reactive lymphoid follicular hyperplasia is a benign proliferation of lymphoid follicles, which can develop wherever lymphoid tissue is present.
  • We present the unique case of an RLFH that involved the radial nerve and presented as a peripheral nerve tumor.
  • Magnetic resonance findings revealed a contrast-enhancing, spindle-shaped tumor, suggestive of a schwannoma or neurofibroma, along the course of the radial nerve.
  • The intraoperative appearance was that of an infiltrating tissue around a lateral branch of the nerve, which could be resected en bloc.
  • Pathologic examination documented hyperplastic lymphoid tissue surrounding the nerve, and immunostaining confirmed the diagnosis of benign reactive follicular hyperplasia.
  • CONCLUSION: To our knowledge this is the first description of RLFH affecting a peripheral nerve and mimicking a neoplasm.
  • This rare and benign condition should be considered in the differential diagnosis of peripheral nerve tumors.
  • [MeSH-major] Peripheral Nervous System Neoplasms / diagnosis. Pseudolymphoma / diagnosis. Radial Neuropathy / diagnosis

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  • (PMID = 18261777.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Selch MT, Lin K, Agazaryan N, Tenn S, Gorgulho A, DeMarco JJ, DeSalles AA: Initial clinical experience with image-guided linear accelerator-based spinal radiosurgery for treatment of benign nerve sheath tumors. Surg Neurol; 2009 Dec;72(6):668-74; discussion 674-5
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  • [Title] Initial clinical experience with image-guided linear accelerator-based spinal radiosurgery for treatment of benign nerve sheath tumors.
  • BACKGROUND: Stereotactic radiosurgery has proven a safe and effective treatment of cranial nerve sheath tumors.
  • A similar approach should be successful for histologically identical spinal nerve sheath tumors.
  • METHODS: The preliminary results of linear accelerator-based spinal radiosurgery were retrospectively reviewed for a group of 25 nerve sheath tumors.
  • Tumor location was cervical 11, lumbar 10, and thoracic 4.
  • Tumor size varied from 0.9 to 4.1 cm (median, 2.1 cm).
  • Median peripheral dose and prescription isodose were 12 Gy and 90%, respectively.
  • Tumor size remained stable in 18 cases, and 7 (28%) demonstrated more than 2 mm reduction in tumor size.
  • CONCLUSIONS: Results of this limited experience indicate linear accelerator-based spinal radiosurgery is feasible for treatment of benign nerve sheath tumors.
  • Further follow-up is necessary, but our results imply spinal radiosurgery may represent a therapeutic alternative to surgery for nerve sheath tumors.
  • [MeSH-major] Neurilemmoma / surgery. Peripheral Nervous System Neoplasms / surgery. Radiosurgery / instrumentation. Spinal Nerves / surgery. Surgery, Computer-Assisted / instrumentation
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / surgery. Neurofibromatosis 1 / diagnosis. Neurofibromatosis 1 / surgery. Neurofibromatosis 2 / diagnosis. Neurofibromatosis 2 / surgery. Neurologic Examination. Postoperative Complications / diagnosis. Young Adult

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  • [Copyright] Copyright 2009 Elsevier Inc. All rights reserved.
  • (PMID = 19608232.001).
  • [ISSN] 1879-3339
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Dhingra KK, Mandal S, Roy S, Khurana N: Malignant peripheral nerve sheath tumor of the breast: case report. World J Surg Oncol; 2007;5:142
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  • [Title] Malignant peripheral nerve sheath tumor of the breast: case report.
  • BACKGROUND: Malignant peripheral nerve sheath tumor is a rare soft tissue sarcoma of ectomesenchymal origin.
  • It is the malignant counterpart of benign soft tissue tumors like neurofibromas and schwannomas and may often follow them.
  • Common sites include deeper soft tissues, usually in the proximity of a nerve trunk.
  • Breast is an extremely rare location of this lesion and presentation as a breast lump in the absence of pain or previous benign neural tumor is even rarer.
  • Histopathology revealed a malignant spindle cell tumor which was confirmed to be malignant peripheral nerve sheath tumor on the basis of immunopositivity for vimentin, neurone specific enolase and S-100.
  • The differential diagnosis of malignant peripheral nerve sheath tumor should be considered by the clinician as well as the pathologists in the work-up of a breast neoplasm as treatment and prognosis of this rare malignancy is different.
  • [MeSH-major] Breast Neoplasms / pathology. Nerve Sheath Neoplasms / pathology. Peripheral Nervous System Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Vimentin / metabolism

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  • (PMID = 18154670.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Vimentin
  • [Other-IDs] NLM/ PMC2246134
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21. Upadhyaya M, Kluwe L, Spurlock G, Monem B, Majounie E, Mantripragada K, Ruggieri M, Chuzhanova N, Evans DG, Ferner R, Thomas N, Guha A, Mautner V: Germline and somatic NF1 gene mutation spectrum in NF1-associated malignant peripheral nerve sheath tumors (MPNSTs). Hum Mutat; 2008 Jan;29(1):74-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Germline and somatic NF1 gene mutation spectrum in NF1-associated malignant peripheral nerve sheath tumors (MPNSTs).
  • About 10% of neurofibromatosis type 1 (NF1) patients develop malignant peripheral nerve sheath tumors (MPNSTs) and represent considerable patient morbidity and mortality.
  • Somatic NF1 mutations were identified in tumor DNA from 31 out of 34 MPNSTs, of which 28 were large genomic deletions.
  • The high prevalence (>90%) of such deletions in MPNST contrast with the =or<20% found in benign neurofibromas and is indicative of the involvement of different mutational mechanisms in these tumors.
  • [MeSH-major] Germ-Line Mutation. Mutation. Nerve Sheath Neoplasms / genetics. Neurofibromin 1 / genetics. Peripheral Nervous System Neoplasms / genetics
  • [MeSH-minor] Adult. DNA Mutational Analysis. DNA, Neoplasm / metabolism. Humans. Loss of Heterozygosity. Lymphocytes / metabolism. Sequence Deletion. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 / metabolism

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17960768.001).
  • [ISSN] 1098-1004
  • [Journal-full-title] Human mutation
  • [ISO-abbreviation] Hum. Mutat.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Neurofibromin 1; 0 / Tumor Suppressor Protein p53
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22. Zou C, Smith KD, Liu J, Lahat G, Myers S, Wang WL, Zhang W, McCutcheon IE, Slopis JM, Lazar AJ, Pollock RE, Lev D: Clinical, pathological, and molecular variables predictive of malignant peripheral nerve sheath tumor outcome. Ann Surg; 2009 Jun;249(6):1014-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical, pathological, and molecular variables predictive of malignant peripheral nerve sheath tumor outcome.
  • OBJECTIVE: Improved staging systems for malignant peripheral nerve sheath tumor (MPNST) prognostication and management are needed.
  • The 5 years DSS for localized tumor patients was 35% for NF-1 patients and 50% for sporadic patients.
  • Ki67, vascular endothelial growth factor, p53, and pMEK were over-expressed in MPNST compared with benign neurofibromas.
  • Only tumor size and nuclear p53 expression were found to be independent prognosticators for MPNST DSS in a multivariable analysis.
  • CONCLUSIONS: MPSNT is a markedly metastatic and aggressive poor prognosis tumor.
  • Multiple clinical, pathologic, and molecular markers identified in this study, coupled with findings from previous series, should be considered for an improved MPNST staging system useful for prognostic assessment and management decisions.
  • [MeSH-major] Neoplasm Recurrence, Local / epidemiology. Nerve Sheath Neoplasms / metabolism. Nerve Sheath Neoplasms / pathology

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  • (PMID = 19474676.001).
  • [ISSN] 1528-1140
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers
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23. Wu J, Crimmins JT, Monk KR, Williams JP, Fitzgerald ME, Tedesco S, Ratner N: Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign world health organization grade I neurofibroma. Am J Pathol; 2006 May;168(5):1686-96
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  • [Title] Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign world health organization grade I neurofibroma.
  • Benign peripheral nerve tumors called neurofibromas are a major source of morbidity for patients with neurofibromatosis type 1.
  • A birth to 2-week pulse of cetuximab blocked hEGFR phosphorylation and Schwann cell prolifera-tion in perinatal mutant nerve, so CNPase-hEGFR Schwann cell numbers correlate with the cetuximab effect.

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  • (PMID = 16651634.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS028840; United States / NCI NIH HHS / CA / T32 CA059268; United States / NINDS NIH HHS / NS / NS28840; United States / NCI NIH HHS / CA / T32-CA-59268
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 0 / Chemotactic Factors; 0 / Fibroblast Growth Factor 9; 0 / Neurofibromin 1; 0 / Oncogene Proteins v-fos; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 3.1.4.- / 2',3'-Cyclic-Nucleotide Phosphodiesterases; PQX0D8J21J / Cetuximab
  • [Other-IDs] NLM/ PMC1606591
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24. Jain TP, Srivastava DN, Mittal R, Gamanagatti S: Fibrolipomatous hamartoma of median nerve. Australas Radiol; 2007 Oct;51 Spec No.:B98-B100
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  • [Title] Fibrolipomatous hamartoma of median nerve.
  • Fibrolipomaous hamartoma is a benign neoplasm of nerves, resulting from anomalous growth of fibroadipose tissue of the nerve sheath.
  • The median nerve is the most commonly involved nerve.
  • [MeSH-major] Fibroma / diagnosis. Hamartoma / diagnosis. Lipoma / diagnosis. Magnetic Resonance Imaging. Median Neuropathy / diagnosis. Peripheral Nervous System Neoplasms / diagnosis

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  • (PMID = 17875173.001).
  • [ISSN] 0004-8461
  • [Journal-full-title] Australasian radiology
  • [ISO-abbreviation] Australas Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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25. Kresse SH, Skårn M, Ohnstad HO, Namløs HM, Bjerkehagen B, Myklebost O, Meza-Zepeda LA: DNA copy number changes in high-grade malignant peripheral nerve sheath tumors by array CGH. Mol Cancer; 2008;7:48
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  • [Title] DNA copy number changes in high-grade malignant peripheral nerve sheath tumors by array CGH.
  • BACKGROUND: Malignant peripheral nerve sheath tumors (MPNSTs) are rare and highly aggressive soft tissue tumors showing complex chromosomal aberrations.
  • Within 17q, the genes topoisomerase II-alpha (TOP2A), ets variant gene 4 (E1A enhancer binding protein, E1AF) (ETV4) and baculoviral IAP repeat-containing 5 (survivin) (BIRC5) showed increased expression in all samples compared to two benign tumors.
  • In addition, we have analyzed the expression of five micro RNAs located within the 17q23.2-q25.3 region, but none of them showed high expression levels compared to the benign tumors.
  • [MeSH-major] DNA, Neoplasm / analysis. Gene Dosage. Gene Expression Profiling / methods. Gene Expression Regulation, Neoplastic. Nerve Sheath Neoplasms / genetics. Oligonucleotide Array Sequence Analysis. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Adenovirus E1A Proteins / genetics. Adult. Aged. Amino Acid Oxidoreductases / genetics. Antigens, Neoplasm / genetics. Chromosomes, Human, Pair 17. Chromosomes, Human, Pair 8. DNA Topoisomerases, Type II / genetics. DNA-Binding Proteins / genetics. Female. Gene Expression Regulation, Enzymologic. Humans. Inhibitor of Apoptosis Proteins. Male. Microtubule-Associated Proteins / genetics. Middle Aged. Neoplasm Proteins / genetics. Prognosis. Proto-Oncogene Proteins / genetics. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 18522746.001).
  • [ISSN] 1476-4598
  • [Journal-full-title] Molecular cancer
  • [ISO-abbreviation] Mol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adenovirus E1A Proteins; 0 / Antigens, Neoplasm; 0 / BIRC5 protein, human; 0 / DNA, Neoplasm; 0 / DNA-Binding Proteins; 0 / ETV4 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; 0 / Proto-Oncogene Proteins; EC 1.4.- / Amino Acid Oxidoreductases; EC 1.4.3.- / LOXL2 protein, human; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
  • [Other-IDs] NLM/ PMC2442610
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26. Newman E, Eichenfield LF: Granular cell tumor on the palm of an 8-year-old girl. Pediatr Dermatol; 2010 Nov-Dec;27(6):656-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor on the palm of an 8-year-old girl.
  • Granular cell tumors are rare benign peripheral nerve neoplasms that are most commonly reported on the tongue and oral mucosa.
  • We report a child with a granular cell tumor of the palm that required removal by an orthopedic hand surgeon.
  • [MeSH-major] Granular Cell Tumor / pathology. Hand. Peripheral Nervous System Neoplasms / pathology

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  • [Copyright] © 2010 Wiley Periodicals, Inc.
  • (PMID = 21510018.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Karube K, Nabeshima K, Ishiguro M, Harada M, Iwasaki H: cDNA microarray analysis of cancer associated gene expression profiles in malignant peripheral nerve sheath tumours. J Clin Pathol; 2006 Feb;59(2):160-5
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  • [Title] cDNA microarray analysis of cancer associated gene expression profiles in malignant peripheral nerve sheath tumours.
  • BACKGROUND: Malignant peripheral nerve sheath tumour (MPNST) is a highly aggressive malignancy that arises within peripheral nerves, and is associated with poor prognosis.
  • AIMS: To identify genes differentially expressed in MPNST compared with benign tumours, such as neurofibromas and schwannomas, by means of cDNA microarray analysis.
  • METHODS: Six MPNST cases and five benign cases (three schwannomas and two neurofibromas) were analysed.
  • Immunohistochemistry confirmed upregulation of survivin in MPNST at the protein level in six of eight cases compared with benign tumours.
  • [MeSH-major] Gene Expression Regulation, Neoplastic. Neoplasm Proteins / biosynthesis. Nerve Sheath Neoplasms / metabolism. Peripheral Nervous System Neoplasms / metabolism

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  • (PMID = 16443732.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; 0 / Tenascin
  • [Other-IDs] NLM/ PMC1860323
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28. Shimose S, Sugita T, Kubo T, Matsuo T, Nobuto H, Tanaka K, Arihiro K, Ochi M: Major-nerve schwannomas versus intramuscular schwannomas. Acta Radiol; 2007 Jul;48(6):672-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Major-nerve schwannomas versus intramuscular schwannomas.
  • BACKGROUND: A schwannoma is a benign peripheral nerve tumor.
  • Predicting the involvement of a nerve on symptoms or magnetic resonance (MR) findings is crucial to the diagnostic process.
  • PURPOSE: To compare symptoms, MR findings, and histological findings between major-nerve schwannomas and intramuscular schwannomas.
  • MATERIAL AND METHODS: Thirty-four patients with 36 palpable schwannomas (29 major-nerve schwannomas and seven intramuscular schwannomas) surgically excised and proven histologically were retrospectively reviewed.
  • RESULTS: Frequencies of the Tinel-like sign, split-fat sign, entering and exiting nerve, and low-signal margin indicate the presence of a nerve, and were significantly higher in major-nerve schwannomas than in intramuscular schwannomas.
  • In tumor morphological patterns (target sign, inhomogeneous and homogeneous pattern), there were no significant differences between major-nerve schwannomas and intramuscular schwannomas.
  • All major-nerve schwannomas and five of the intramuscular schwannomas produced some characteristic symptoms and/or MR findings, but two intramuscular schwannomas did not have any characteristic symptoms and findings.
  • CONCLUSION: In major-nerve schwannomas, the Tinel-like sign, split-fat sign, entering and exiting nerve, and low-signal margin are commonly observed and useful for diagnosis.
  • [MeSH-major] Muscle Neoplasms / diagnosis. Neurilemmoma / diagnosis. Peripheral Nervous System Neoplasms / diagnosis

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  • (PMID = 17611877.001).
  • [ISSN] 0284-1851
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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29. Aoki M, Nabeshima K, Koga K, Hamasaki M, Suzumiya J, Tamura K, Iwasaki H: Imatinib mesylate inhibits cell invasion of malignant peripheral nerve sheath tumor induced by platelet-derived growth factor-BB. Lab Invest; 2007 Aug;87(8):767-79
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imatinib mesylate inhibits cell invasion of malignant peripheral nerve sheath tumor induced by platelet-derived growth factor-BB.
  • Malignant peripheral nerve sheath tumor (MPNST) is rare, highly aggressive, resistant to radiochemotherapy, and associated with poor prognosis.
  • Expressions of PDGF-BB and EGF receptors (PDGFR-beta and EGFR) mRNAs were detected more frequently and their proteins were expressed at higher levels in MPNST tissues than benign peripheral nerve sheath tumors (schwannomas and neurofibromas).
  • [MeSH-major] Antineoplastic Agents / pharmacology. Nerve Sheath Neoplasms / metabolism. Piperazines / pharmacology. Platelet-Derived Growth Factor / pharmacology. Pyrimidines / pharmacology
  • [MeSH-minor] Adult. Benzamides. Cell Line, Tumor. Female. Humans. Imatinib Mesylate. Intercellular Signaling Peptides and Proteins / pharmacology. Intercellular Signaling Peptides and Proteins / physiology. Male. Middle Aged. Mutation. Neoplasm Invasiveness. Phosphorylation. Proto-Oncogene Proteins c-sis. RNA, Messenger / metabolism. Receptor, Platelet-Derived Growth Factor beta / antagonists & inhibitors. Receptor, Platelet-Derived Growth Factor beta / genetics. Receptor, Platelet-Derived Growth Factor beta / metabolism. Receptors, Growth Factor / genetics. Receptors, Growth Factor / metabolism

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  • (PMID = 17558420.001).
  • [ISSN] 0023-6837
  • [Journal-full-title] Laboratory investigation; a journal of technical methods and pathology
  • [ISO-abbreviation] Lab. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Intercellular Signaling Peptides and Proteins; 0 / Piperazines; 0 / Platelet-Derived Growth Factor; 0 / Proto-Oncogene Proteins c-sis; 0 / Pyrimidines; 0 / RNA, Messenger; 0 / Receptors, Growth Factor; 0 / platelet-derived growth factor BB; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor beta
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30. Agaimy A, Wuensch PH: Perineurioma of the stomach. A rare spindle cell neoplasm that should be distinguished from gastrointestinal stromal tumor. Pathol Res Pract; 2005;201(6):463-7
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  • [Title] Perineurioma of the stomach. A rare spindle cell neoplasm that should be distinguished from gastrointestinal stromal tumor.
  • We report on the first case of benign perineurially differentiated peripheral nerve sheath tumor (perineurioma) presenting as a bleeding gastric mass in a 30-year-old, previously healthy woman with no signs or stigmata of von Recklinghausen's disease or other primary tumor at time of presentation.
  • Gastric resection specimen revealed an ulcerated moderately cellular mesenchymal tumor consisting of elongated wavy spindle cells arranged in a fascicular and sheet-like pattern with focal whorling and occasional alternation of dark staining cellular and light staining hypocellular areas.
  • Tumor cells were strongly immunoreactive for epithelial membrane antigen, CD56 (N-CAM), and vimentin, but were negative for S-100-protein and other lineage-specific epithelial, mesenchymal, hematolymphoid, and reticulo-histiocytic markers.
  • We presume that the combined histological and immunohistochemical profiles of this unusual gastric neoplasm are consistent with a diagnosis of perineurioma with a probably benign biological behavior.
  • To our knowledge, this is the first report of gastric perineurioma, an extremely rare mesenchymal lesion that should be considered among the differential diagnoses of gastrointestinal stromal tumor, especially the so-called KIT-negative GIST.
  • Gastrointestinal perineuriomas might be under-recognized, as our case was initially diagnosed as a benign GIST.
  • [MeSH-major] Gastrointestinal Neoplasms / diagnosis. Nerve Sheath Neoplasms / pathology. Stomach Neoplasms / pathology. Stromal Cells / pathology
  • [MeSH-minor] Adult. Antigens, CD56 / metabolism. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Mucin-1 / metabolism. Treatment Outcome

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  • (PMID = 16136753.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Biomarkers, Tumor; 0 / Mucin-1
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31. Kawamura K, Yajima H, Morishita T, Honoki K, Takakura Y: Plexiform schwannoma of the ulnar nerve. Scand J Plast Reconstr Surg Hand Surg; 2005;39(2):120-2
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  • [Title] Plexiform schwannoma of the ulnar nerve.
  • Plexiform schwannoma is a rare benign neurogenic tumour; we report a case that arose in the ulnar nerve of a 59-year-old woman.
  • Exploration showed a continuous multinodular tumour that involved the ulnar nerve from the hand to the upper arm; the length of the tumour was 35 cm.

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  • (PMID = 16019742.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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32. Subramanian S, Thayanithy V, West RB, Lee CH, Beck AH, Zhu S, Downs-Kelly E, Montgomery K, Goldblum JR, Hogendoorn PC, Corless CL, Oliveira AM, Dry SM, Nielsen TO, Rubin BP, Fletcher JA, Fletcher CD, van de Rijn M: Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumours. J Pathol; 2010 Jan;220(1):58-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumours.
  • Malignant peripheral nerve sheath tumours (MPNSTs) are aggressive soft tissue tumours that occur either sporadically or in patients with neurofibromatosis type 1.
  • The malignant transformation of the benign neurofibroma to MPNST is incompletely understood at the molecular level.
  • We have determined the gene expression signature for benign and malignant PNSTs and found that the major trend in malignant transformation from neurofibroma to MPNST consists of the loss of expression of a large number of genes, rather than widespread increase in gene expression.
  • Relatively few genes are expressed at higher levels in MPNSTs and these include genes involved in cell proliferation and genes implicated in tumour metastasis.
  • Subsequent microRNA profiling of benign and malignant PNSTs indicated a relative down-regulation of miR-34a in most MPNSTs compared to neurofibromas.
  • Collectively, our findings suggest that deregulation of miRNAs has a potential role in the malignant transformation process in peripheral nerve sheath tumours.
  • [MeSH-major] Genes, p53. MicroRNAs / metabolism. Nerve Sheath Neoplasms / genetics. RNA, Neoplasm / metabolism
  • [MeSH-minor] Adult. Apoptosis / genetics. Cell Adhesion / genetics. Cell Proliferation. Cluster Analysis. Down-Regulation. Female. Gene Expression Profiling / methods. Gene Expression Regulation, Neoplastic. Gene Silencing. Humans. Male. Middle Aged. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism. Neurofibroma. Oligonucleotide Array Sequence Analysis / methods. Receptor, Epidermal Growth Factor / genetics. Receptor, Epidermal Growth Factor / metabolism. Reverse Transcriptase Polymerase Chain Reaction / methods. Signal Transduction / genetics. Tumor Cells, Cultured. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 19890883.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P50 CA127003; United States / NCI NIH HHS / CA / P50 CA127003-03
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / MIRN34 microRNA, human; 0 / MicroRNAs; 0 / Neoplasm Proteins; 0 / RNA, Neoplasm; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
  • [Other-IDs] NLM/ NIHMS212333; NLM/ PMC4058327
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33. Østergaard JR, Smith T, Stausbøl-Grøn B: Intraneural perineurioma of the sciatic nerve in early childhood. Pediatr Neurol; 2009 Jul;41(1):68-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraneural perineurioma of the sciatic nerve in early childhood.
  • Intraneural perineurioma is an uncommon benign neoplasm characterized by focal perineural cell proliferation.
  • In early childhood, uncertainty concerning the time of onset can lead to difficulty in distinguishing this potential treatable lesion from congenital and other causes of nerve palsy.
  • In the present case, clinical presentation, electrophysiologic findings, and magnetic resonance imaging findings in a child were compatible with intraneural perineurioma of the lumbosacral trunk and sciatic nerve.
  • The case illustrates that sciatic intraneural perineuriomas do occur in early childhood, and that traction on the sciatic nerve may result in earlier damage to the peroneal nerve than to the tibial nerve, thus mimicking a more peripheral lesion.
  • [MeSH-major] Nerve Sheath Neoplasms / diagnosis. Sciatic Neuropathy / diagnosis

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  • (PMID = 19520281.001).
  • [ISSN] 1873-5150
  • [Journal-full-title] Pediatric neurology
  • [ISO-abbreviation] Pediatr. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Ulrich D, Ulrich F, Schroeder M, Pallua N: Lipofibromatous hamartoma of the median nerve in patients with macrodactyly: diagnosis and treatment of a rare disease causing carpal tunnel syndrome. Arch Orthop Trauma Surg; 2009 Sep;129(9):1219-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lipofibromatous hamartoma of the median nerve in patients with macrodactyly: diagnosis and treatment of a rare disease causing carpal tunnel syndrome.
  • Lipofibromatous hamartoma is a very rare benign peripheral nerve tumour.
  • It is mostly encountered in the proximal extremities of young adults, involving the median nerve in the majority of cases.
  • We present two patients with macrodactyly and carpal tunnel syndrome caused by lipofibromatous hamartoma of the median nerve and discuss diagnosis and treatment of the disease.
  • A 10-year-old girl with a congenital progressive macrodactyly of her right index finger presented with a slowly growing mass in her right palm and pain and numbness, along with motor and sensory deficits in the median nerve distribution.
  • Intraoperatively, the lesion presented as sausage-shaped enlargement of the median nerve by fibrofatty tissue.
  • In both patients, histology showed nerve bundles separated by abundant fibrofatty tissue.
  • Treatment should include decompression of the median nerve at points of compression, partial excision of the fibrofatty tissue, and debulking of soft tissue.
  • [MeSH-minor] Adipose Tissue / surgery. Adult. Child. Diagnosis, Differential. Female. Fingers / abnormalities. Hand Deformities, Congenital / complications. Humans. Male. Median Nerve / surgery. Thumb / abnormalities. Treatment Outcome

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  • (PMID = 18615252.001).
  • [ISSN] 1434-3916
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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35. Strom T, Kleinschmidt-Demasters BK, Donson A, Foreman NK, Lillehei KO: Rare nerve lesions of non-nerve sheath origin: a 17-year retrospective series. Arch Pathol Lab Med; 2009 Sep;133(9):1391-402
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rare nerve lesions of non-nerve sheath origin: a 17-year retrospective series.
  • CONTEXT: Peripheral nerve masses are frequently encountered in surgical pathology practice.
  • However, once a peripheral nerve mass is determined not to be a nerve sheath neoplasm, differential diagnostic considerations drop off sharply.
  • OBJECTIVE: To review our experience with surgically resected nerve masses.
  • Rare neoplasms were studied by cytogenetic analysis or gene microarray.
  • After elimination of common lesions (mostly nerve sheath tumors), 37 cases (8%) remained, almost all of which were of non-nerve sheath origin: for example, hemangioma, metastatic neuroendocrine pancreatic carcinoma, meningiomas invading nerve fascicles, and primary extrarenal rhabdoid tumor and Ewing sarcoma of nerve.
  • The gene expression pattern of an undifferentiated sarcoma, presenting as ropelike nerve enlargement, clustered with malignant peripheral nerve sheath neoplasms but not other sarcomas or neuroepithelial tumors.
  • CONCLUSIONS: Diverse benign and malignant conditions can affect peripheral nerve.
  • [MeSH-major] Hemangioma / pathology. Meningioma / pathology. Pancreatic Neoplasms / pathology. Peripheral Nervous System Neoplasms / pathology. Rhabdoid Tumor / pathology. Sarcoma, Ewing / pathology

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  • (PMID = 19722745.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunoglobulin Heavy Chains
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36. Hameetman L, Rozeman LB, Lombaerts M, Oosting J, Taminiau AH, Cleton-Jansen AM, Bovée JV, Hogendoorn PC: Peripheral chondrosarcoma progression is accompanied by decreased Indian Hedgehog signalling. J Pathol; 2006 Aug;209(4):501-11
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  • [Title] Peripheral chondrosarcoma progression is accompanied by decreased Indian Hedgehog signalling.
  • PTHLH signalling is absent in osteochondromas, benign tumours arising adjacent to the growth plate, but is reactivated when these tumours undergo malignant transformation towards secondary peripheral chondrosarcoma.
  • We describe a gradual decrease in the expression of Patched (PTCH) and glioma-associated oncogene homologue 1 (GLI1) (both transcribed upon IHH activity), and GLI2 with increasing malignancy, suggesting that IHH signalling is inactive and PTHLH signalling is IHH independent in secondary peripheral chondrosarcomas. cDNA expression profiling and immunohistochemical studies suggest that transforming growth factor-beta (TGF-beta)-mediated proliferative signalling is active in high-grade chondrosarcomas since TGF-beta downstream targets were upregulated in these tumours.
  • Thus, the tight regulation of growth plate organization by IHH signalling is still seen in osteochondroma, but gradually lost during malignant transformation to secondary peripheral chondrosarcoma and subsequent progression.
  • TGF-beta signalling is stimulated during secondary peripheral chondrosarcoma progression and could potentially regulate the retained activity of PTHLH.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chi-Square Distribution. Child. Disease Progression. Female. Gene Expression Profiling. Growth Plate / metabolism. Hedgehog Proteins. Humans. Immunohistochemistry / methods. Male. Membrane Proteins / genetics. Middle Aged. Neoplasm Proteins / genetics. Nerve Tissue Proteins / genetics. Oligonucleotide Array Sequence Analysis. Osteosarcoma / genetics. Osteosarcoma / pathology. Plasminogen Activator Inhibitor 1 / genetics. Proto-Oncogene Proteins c-jun / genetics. Reverse Transcriptase Polymerase Chain Reaction. Smad2 Protein / genetics. Transforming Growth Factor beta / genetics. Transforming Growth Factor beta / metabolism. Wnt1 Protein / genetics. Wnt1 Protein / metabolism. beta Catenin / genetics

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  • [Copyright] Copyright 2006 Pathological Society of Great Britain and Ireland.
  • (PMID = 16755518.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / GLIPR1 protein, human; 0 / GLIPR2 protein, human; 0 / Hedgehog Proteins; 0 / IHH protein, human; 0 / Intercellular Signaling Peptides and Proteins; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / Nerve Tissue Proteins; 0 / Plasminogen Activator Inhibitor 1; 0 / Proto-Oncogene Proteins c-jun; 0 / SERPINE1 protein, human; 0 / SMAD2 protein, human; 0 / Smad2 Protein; 0 / Transforming Growth Factor beta; 0 / Wnt1 Protein; 0 / beta Catenin
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37. Niwa T, Aida N, Fujita K, Kitagawa N, Sato Y, Tanaka Y, Inoue T: Diffusion-weighted imaging of retroperitoneal malignant peripheral nerve sheath tumor in a patient with neurofibromatosis type 1. Magn Reson Med Sci; 2008;7(1):49-53
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  • [Title] Diffusion-weighted imaging of retroperitoneal malignant peripheral nerve sheath tumor in a patient with neurofibromatosis type 1.
  • We present the diffusion-weighted imaging (DWI) findings for a malignant peripheral nerve sheath tumor arising in a retroperitoneal plexiform neurofibroma in a patient with neurofibromatosis type 1.
  • Signal intensity of the malignant area was high on DWI and low on the apparent diffusion coefficient map and differed from findings for the benign area.
  • DWI enabled clear differentiation between malignant and benign areas of the tumor.
  • [MeSH-major] Diffusion Magnetic Resonance Imaging / methods. Nerve Sheath Neoplasms / diagnosis. Neurofibromatosis 1 / complications. Retroperitoneal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Neoplasm Recurrence, Local. Reoperation


38. Subhashraj K, Balanand S, Pajaniammalle S: Ancient schwannoma arising from mental nerve. A case report and review. Med Oral Patol Oral Cir Bucal; 2009 Jan;14(1):E12-4
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  • [Title] Ancient schwannoma arising from mental nerve. A case report and review.
  • Schwannoma is an intraoral rare, benign neoplasm derived from the nerve sheath of peripheral nerves.
  • "Ancient schwannoma" shows histopathological features, such as degenerative changes and atypical nuclei, and may easily be confused with malignant neoplasms.
  • We present a case of ancient schwannoma arising from the mental nerve in a 19 year old male which was of eight months duration.
  • Ultrasonography showed that the tumor was closely associated with the mental nerve on the left side, suggestive of a peripheral neural sheath tumor.
  • Complete excision of the lesion was done under local anesthesia, preserving the mental nerve.
  • [MeSH-major] Chin / innervation. Neurilemmoma / pathology. Peripheral Nervous System Neoplasms / pathology

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  • (PMID = 19114949.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 11
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39. Smehák G, Rovó L, Tiszlavicz L, Jóri J: Perineurioma originating from the recurrent laryngeal nerve, and the phonochirurgical treatment of the developed vocal fold palsy. Eur Arch Otorhinolaryngol; 2008 Feb;265(2):237-41
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  • [Title] Perineurioma originating from the recurrent laryngeal nerve, and the phonochirurgical treatment of the developed vocal fold palsy.
  • Perineurioma is a rare, benign tumour of the perineurium, which develops mostly on the nerves of the extremities.
  • The neoplasm related to a genetic mutation on the 22nd chromosome, is a rarity on the vagal nerve branches.
  • Authors report the case of a 15-year-old female with an immunhistochemically verified (focal EMA positive, vimentin, CD56 positive) perineurioma originating from the left recurrent laryngeal nerve.
  • After the removal of the tumour together with the involved 2-cm-long part of the nerve, vocal fold palsy developed with aphonia (left vocal fold was in intermedian position).
  • [MeSH-major] Dysphonia / etiology. Nerve Sheath Neoplasms / pathology. Otorhinolaryngologic Surgical Procedures / methods. Peripheral Nervous System Neoplasms / pathology. Recurrent Laryngeal Nerve / pathology. Vocal Cord Paralysis / etiology. Vocal Cord Paralysis / surgery

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  • (PMID = 17687560.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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40. Ferner RE, Golding JF, Smith M, Calonje E, Jan W, Sanjayanathan V, O'Doherty M: [18F]2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) as a diagnostic tool for neurofibromatosis 1 (NF1) associated malignant peripheral nerve sheath tumours (MPNSTs): a long-term clinical study. Ann Oncol; 2008 Feb;19(2):390-4
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  • [Title] [18F]2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) as a diagnostic tool for neurofibromatosis 1 (NF1) associated malignant peripheral nerve sheath tumours (MPNSTs): a long-term clinical study.
  • BACKGROUND: Malignant peripheral nerve sheath tumours (MPNSTs) are difficult to detect in neurofibromatosis 1 (NF1) individuals.
  • Biopsy confirmed the findings in 59 tumours and no MPNST was diagnosed on clinical follow-up of 23 lesions diagnosed as benign on FDG PET and PET CT.
  • FDG PET and PET CT diagnosed NF1-associated tumours with a sensitivity of 0.89 [95% confidence interval (CI) 0.76-0.96] and a specificity of 0.95 (CI 0.88-0.98), but the SUVmax level did not predict tumour grade.
  • Other PET tracers will be required to solve the problem of predicting tumour grade.


41. Touzri RA, Errais K, Zermani R, Benjilani S, Ouertani A: Schwannoma of the eyelid: apropos of two cases. Indian J Ophthalmol; 2009 Jul-Aug;57(4):318-20
Genetic Alliance. consumer health - Schwannoma.

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  • Schwannoma, also referred to as neurilemmoma, is a benign tumor of peripheral nerve arising from Schwann cells that form the neural sheath.
  • [MeSH-major] Eyelid Neoplasms / pathology. Neurilemmoma / pathology
  • [MeSH-minor] Antigens, Neoplasm / metabolism. Female. Humans. Immunochemistry. Male. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / metabolism. Rare Diseases. S100 Proteins / metabolism. Young Adult

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  • [Cites] Br J Ophthalmol. 1982 Mar;66(3):194-204 [7066273.001]
  • [Cites] Arch Ophthalmol. 1984 Nov;102(11):1650 [6497748.001]
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  • (PMID = 19574706.001).
  • [ISSN] 1998-3689
  • [Journal-full-title] Indian journal of ophthalmology
  • [ISO-abbreviation] Indian J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins
  • [Other-IDs] NLM/ PMC2712707
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42. Al-Daraji WI: Granular perineurioma: the first report of a rare distinctive subtype of perineurioma. Am J Dermatopathol; 2008 Apr;30(2):163-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Perineurioma represents a relatively recently described neoplasm in the spectrum of benign peripheral nerve sheath tumors composed of perineurial cells staining immunohistochemically positive for epithelial membrane antigen.
  • More interestingly, 3 years later the patient complained of right lower extremity pain, for which magnetic resonance imaging studies showed an intraneural perineurioma confined to the sciatic nerve.
  • Interestingly, the granular component of this large tumor (4.5 cm in maximum diameter) was negative for S100, but positive for NKI-C3.
  • The morphology, immunohistochemistry, and the clinical behavior for this tumor and the differential diagnoses are discussed.
  • [MeSH-major] Lipoma / pathology. Nerve Sheath Neoplasms / pathology. Peripheral Nervous System Neoplasms / pathology. Sciatic Nerve / pathology. Soft Tissue Neoplasms / pathology

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  • [CommentIn] Am J Dermatopathol. 2008 Dec;30(6):636 [19033949.001]
  • (PMID = 18360122.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Piña-Oviedo S, Ortiz-Hidalgo C: The normal and neoplastic perineurium: a review. Adv Anat Pathol; 2008 May;15(3):147-64
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  • Peripheral nerves consist of 3 layers with differing characteristics: the endoneurium, perineurium, and epineurium.
  • The perineurium represents a continuum with the pia-arachnoid from the central nervous system and extends distally with the sheath of capsular cells of peripheral sensorial organs and propioceptive receptors.
  • It is made of layers of flattened cells surrounded by a basement membrane and collagen fibers, forming concentrically laminated structures around single nerve fascicles.
  • Functionally, the perineurium modulates external stretching forces (that could be potentially harmful for nerve fibers), and along with endoneurial vessels, forms the blood-nerve barrier.
  • Perineurial invasion is considered an important prognostic factor in several malignant neoplasms.
  • Perineuriomas are true benign infrequent perineurial cell neoplasms that have been divided in 2 categories: those with intraneural localization and a more common extraneural (soft tissue) group, including sclerosing and reticular variants.
  • Interestingly, neurofibromas and malignant peripheral nerve sheath tumors may also display perineurial cell differentiation.
  • The histologic appearance of perineuriomas may overlap with other soft tissue spindle cell neoplasms.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Peripheral Nerves / anatomy & histology. Peripheral Nerves / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Blood-Nerve Barrier / anatomy & histology. Blood-Nerve Barrier / chemistry. Blood-Nerve Barrier / pathology. Chromosome Aberrations. DNA, Neoplasm / analysis. Humans. Immunohistochemistry. Karyotyping. Neurons / chemistry. Neurons / cytology. Neurons / pathology

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  • (PMID = 18434767.001).
  • [ISSN] 1533-4031
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm
  • [Number-of-references] 98
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44. Siqueira MG, Martins RS, Teixeira MJ: Management of brachial plexus region tumours and tumour-like conditions: relevant diagnostic and surgical features in a consecutive series of eighteen patients. Acta Neurochir (Wien); 2009 Sep;151(9):1089-98
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  • [Title] Management of brachial plexus region tumours and tumour-like conditions: relevant diagnostic and surgical features in a consecutive series of eighteen patients.
  • FINDINGS: The tumours comprised a heterogeneous group of lesions, including schwannomas, neurofibromas, malignant peripheral nerve sheath tumour (MPNST), sarcomas, metastases, desmoids and an aneurysmal bone cyst.
  • Eleven tumours were benign and 7 were malignant.
  • CONCLUSIONS: The majority of tumours were benign and most of them could be excised with a low incidence of additional deficits.
  • [MeSH-major] Brachial Plexus / pathology. Brachial Plexus / surgery. Brachial Plexus Neuropathies / diagnosis. Brachial Plexus Neuropathies / surgery. Peripheral Nervous System Neoplasms / diagnosis. Peripheral Nervous System Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Bone Cysts, Aneurysmal / diagnosis. Bone Cysts, Aneurysmal / pathology. Bone Cysts, Aneurysmal / surgery. Child. Female. Fibromatosis, Aggressive / diagnosis. Fibromatosis, Aggressive / physiopathology. Fibromatosis, Aggressive / surgery. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Metastasis / diagnosis. Neoplasm Metastasis / physiopathology. Neoplasm Recurrence, Local / epidemiology. Nerve Sheath Neoplasms / diagnosis. Nerve Sheath Neoplasms / physiopathology. Nerve Sheath Neoplasms / surgery. Neurilemmoma / diagnosis. Neurilemmoma / physiopathology. Neurilemmoma / surgery. Neurofibroma / diagnosis. Neurofibroma / physiopathology. Neurofibroma / surgery. Neurosurgical Procedures. Pain / etiology. Paresthesia / etiology. Postoperative Complications / epidemiology. Retrospective Studies. Sarcoma / diagnosis. Sarcoma / physiopathology. Sarcoma / surgery. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • (PMID = 19448970.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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45. Mentzel T, Kutzner H: Reticular and plexiform perineurioma: clinicopathological and immunohistochemical analysis of two cases and review of perineurial neoplasms of skin and soft tissues. Virchows Arch; 2005 Oct;447(4):677-82
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  • [Title] Reticular and plexiform perineurioma: clinicopathological and immunohistochemical analysis of two cases and review of perineurial neoplasms of skin and soft tissues.
  • Perineurioma represents a recently described and relatively rare neoplasm in the spectrum of benign peripheral nerve sheath tumours composed of perineurial cells staining immunohistochemically positive for epithelial membrane antigen (EMA).
  • In addition to intraneural, extraneural and sclerosing perineurioma, rare variants of perineurioma may occur, and their knowledge is important in the differential diagnosis of mesenchymal tumours of different lines of differentiation and clinically more aggressive neoplasms.
  • The morphological spectrum and the differential diagnosis of perineurial neoplasms of skin and soft tissues are discussed.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16133356.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CLDN1 protein, human; 0 / Claudin-1; 0 / Glucose Transporter Type 1; 0 / Membrane Proteins; 0 / Mucin-1; 0 / S100 Proteins
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46. Gläsker S, Berlis A, Pagenstecher A, Vougioukas VI, Van Velthoven V: Characterization of hemangioblastomas of spinal nerves. Neurosurgery; 2005 Mar;56(3):503-9; discussion 503-9

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  • OBJECTIVE: Hemangioblastoma is classified as a benign tumor of the central nervous system.
  • Peripheral nervous system hemangioblastomas to date have been described only in a few case reports.
  • METHODS: To characterize these lesions better, we reviewed our hemangioblastoma database for patients who underwent surgery for extradural hemangioblastoma of the spinal nerve.
  • RESULTS: Between 1983 and 2003, six patients underwent surgery for spinal nerve hemangioblastomas at our institution.
  • These tumors occurred in 2% of all patients with hemangioblastomas of the central nervous system, or 6% of all patients with spinal hemangioblastomas.
  • In general, the tumors are surgically more challenging, and clinically significant bleeding as well as local tumor recurrence is more common than in intradural hemangioblastomas, mostly because of the frequency of incorrect initial radiographic diagnosis.
  • We suggest that because of the surgical consequences, hemangioblastoma should always be considered to be an important radiological differential diagnosis for nerve sheath tumors.
  • [MeSH-major] Hemangioblastoma / pathology. Hemangioma, Capillary / pathology. Peripheral Nervous System Neoplasms / pathology. Spinal Nerves / pathology
  • [MeSH-minor] Adult. Blood Loss, Surgical. Diagnosis, Differential. Female. Humans. Infratentorial Neoplasms / epidemiology. Infratentorial Neoplasms / pathology. Infratentorial Neoplasms / radiography. Infratentorial Neoplasms / surgery. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local. Neurilemmoma / diagnosis. Neuroma / diagnosis. Retrospective Studies. Treatment Outcome. von Hippel-Lindau Disease / epidemiology. von Hippel-Lindau Disease / pathology. von Hippel-Lindau Disease / radiography. von Hippel-Lindau Disease / surgery

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  • (PMID = 15730575.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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47. Lehnhardt M, Daigeler A, Homann HH, Hauser J, Langer S, Steinsträsser L, Soimaru C, Puls A, Steinau HU: [Importance of specialized centers in diagnosis and treatment of extremity-soft tissue sarcomas. Review of 603 cases]. Chirurg; 2009 Apr;80(4):341-7
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  • Due to the disorder's rarity, multitude of subgroups, sometimes varying histopathologic appearance, and occasionally inadequate biopsy specimens, diagnosis and grading are challenging.
  • The records of 603 patients with soft tissue tumors of the extremities were reviewed concerning mismatches in primary and definite diagnoses relating to entity, evaluation of primary or recurrent tumor specimens, and the diagnosing pathology institution.
  • In the eight most frequent sarcoma types, malignant peripheral nerve sheath tumors and leiomyosarcoma had the highest rates of false primary diagnosis, 78.4% and 74.2% of cases, respectively.
  • [MeSH-major] Cancer Care Facilities. Extremities / surgery. Hospitals, Special. Hospitals, University. Sarcoma / diagnosis. Sarcoma / surgery. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Child. Combined Modality Therapy. Diagnostic Errors. Female. Germany. Histiocytoma, Benign Fibrous / diagnosis. Histiocytoma, Benign Fibrous / pathology. Histiocytoma, Benign Fibrous / surgery. Humans. Leiomyosarcoma / diagnosis. Leiomyosarcoma / pathology. Leiomyosarcoma / surgery. Liposarcoma / diagnosis. Liposarcoma / pathology. Liposarcoma / surgery. Male. Middle Aged. Neoplasm Staging. Nerve Sheath Neoplasms / diagnosis. Nerve Sheath Neoplasms / pathology. Nerve Sheath Neoplasms / surgery. Radiotherapy, Adjuvant. Referral and Consultation. Retrospective Studies. Young Adult

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  • (PMID = 18523742.001).
  • [ISSN] 1433-0385
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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48. Rubin AI, Yassaee M, Johnson W, Elenitsas R, Zaladonis J Jr, Seykora JT: Multiple cutaneous sclerosing perineuriomas: an extensive presentation with involvement of the bilateral upper extremities. J Cutan Pathol; 2009 Oct;36 Suppl 1:60-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A perineurioma is a benign peripheral nerve sheath neoplasm thought to be derived from cells of the perineurium, the cellular sheathing of peripheral nerve fascicles.
  • [MeSH-major] Neoplasms, Multiple Primary / pathology. Nerve Sheath Neoplasms / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19187114.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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49. Sabah M, Cummins R, Leader M, Kay E: Leiomyosarcoma and malignant fibrous histiocytoma share similar allelic imbalance pattern at 9p. Virchows Arch; 2005 Mar;446(3):251-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The frequency of allelic imbalance at different loci on chromosome 9p was analysed in LMS and MFH and then compared with values previously examined in synovial sarcoma and malignant peripheral nerve sheath tumour.
  • Alterations of this locus were very rare in synovial sarcoma and malignant peripheral nerve sheath tumours and were absent in cutaneous LMS and angiomatoid fibrous histiocytoma.
  • This locus may point to the existence of a genetically altered tumour suppressor gene involved in the pathogenesis of LMS and MFH.
  • Our results support the hypothesis that MFHs may represent a morphological pathway in tumour progression of LMSs.
  • [MeSH-major] Chromosomes, Human, Pair 9 / genetics. DNA, Neoplasm / genetics. Histiocytoma, Benign Fibrous / genetics. Leiomyosarcoma / genetics. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Allelic Imbalance. Humans. Immunohistochemistry. Loss of Heterozygosity. Microsatellite Repeats. Nerve Sheath Neoplasms / genetics. Polymerase Chain Reaction. Sarcoma, Synovial / genetics

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  • (PMID = 15731925.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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50. Ahrens WA, Ridenour RV 3rd, Caron BL, Miller DV, Folpe AL: GLUT-1 expression in mesenchymal tumors: an immunohistochemical study of 247 soft tissue and bone neoplasms. Hum Pathol; 2008 Oct;39(10):1519-26
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] GLUT-1 expression in mesenchymal tumors: an immunohistochemical study of 247 soft tissue and bone neoplasms.
  • However, GLUT-1 expression has not been systematically examined in other mesenchymal neoplasms.
  • Prompted by a recent report of GLUT-1 expression in epithelioid sarcoma, a tumor not generally felt to show perineurial differentiation, we examined GLUT-1 expression in a wide variety of mesenchymal tumors.
  • Sections from 247 mesenchymal tumors of a variety of histologic subtypes were retrieved from our archives and immunostained for GLUT-1 using heat-induced epitope retrieval and the DAKO ADVANCE detection system (DAKO, Carpinteria, CA).
  • All benign nerve sheath tumors showed a peripheral rim of positive normal perineurial cells, with 2 neurofibromas and 3 schwannomas showing more extensive staining.
  • GLUT-1 expression was also seen in a wide variety of benign and malignant mesenchymal tumors.
  • [MeSH-major] Bone Neoplasms / metabolism. Glucose Transporter Type 1 / metabolism. Mesenchymoma / metabolism. Soft Tissue Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cell Count. Humans. Immunohistochemistry. Neoplasm Proteins / metabolism

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  • (PMID = 18620729.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glucose Transporter Type 1; 0 / Neoplasm Proteins
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51. Pata YS, Akbaş Y, Unal M, Tataroğlu C: A case of intranasal schwannoma with bilateral nasal polyposis. Kulak Burun Bogaz Ihtis Derg; 2005;15(1-2):45-8
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  • Schwannoma is a benign neoplasm originating from schwann cells of the peripheral nerve sheath, and its occurrence in the nasal cavity and paranasal sinuses is rare.
  • [MeSH-major] Nasal Polyps / diagnosis. Neurilemmoma / diagnosis. Nose Neoplasms / diagnosis

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  • (PMID = 16340292.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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52. Campanati A, Brandozzi G, Sisti S, Bernardini ML, Offidani AM: Atypical neurothekeoma: a new case and review of the literature. J Cutan Pathol; 2007 May;34(5):435-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Neurothekeoma is a rare neoplasm ascribed into the broad category of benign peripheral nerve sheath tumors.
  • The atypical cellular variant of this neoplasm, showing a peculiar histological pattern, has been very rarely reported in literature.
  • RESULTS: The described neoplasm showed the histological features of atypical variant of cellular neurothekeoma with high-rate mitotic activity and deep penetration into subcutaneous fat.
  • CONCLUSIONS: Because only few cases of atypical neurothekeoma have been reported in literature, clinical and morphological available data on this neoplasm are very few, and its prognosis remains uncertain; anyway, dermatologists should be aware of histological features of this neoplasm for which a complete surgical excision is recommended.
  • [MeSH-major] Chin / pathology. Neurothekeoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 17448203.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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53. Joyner DE, Wade ML, Szabo A, Bastar J, Coffin CM, Albritton KH, Bernard PS, Randall RL: Discriminate gene lists derived from cDNA microarray profiles of limited samples permit distinguishing mesenchymal neoplasia ex vivo. J Cancer Res Clin Oncol; 2005 Mar;131(3):137-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Discriminate gene lists derived from cDNA microarray profiles of limited samples permit distinguishing mesenchymal neoplasia ex vivo.
  • BACKGROUND: Mesenchymal neoplasia comprises a heterogeneous group of tumors with over 200 benign neoplasms and 100 sarcomas.
  • Messenger RNA (mRNA) from four general tumor classes was competitively hybridized against a human dermal fibroblast cell line comparator and the resulting gene expression profiles processed by ANOVA and linear discriminate analysis.
  • RESULTS: The tissue classification involved 18 patients with malignant peripheral nerve sheath tumors, giant cell containing tumors, benign spindle cell lesions, or Ewing's family of tumors.
  • CONCLUSIONS: Linear discriminate analysis of cDNA gene expression profiles partitioned mesenchymal tumor classes, even when constrained by limited sample sizes.
  • [MeSH-major] DNA Fingerprinting. DNA, Neoplasm / analysis. Mesenchymoma / diagnosis. Mesenchymoma / genetics. Neoplasms, Connective Tissue / diagnosis. Neoplasms, Connective Tissue / genetics. Oligonucleotide Array Sequence Analysis
  • [MeSH-minor] Analysis of Variance. Carcinoma / diagnosis. Carcinoma / genetics. Carcinoma, Giant Cell / diagnosis. Carcinoma, Giant Cell / genetics. Cell Line. Feasibility Studies. Fibroblasts. Gene Expression Regulation, Neoplastic. Humans. Linear Models. Nerve Sheath Neoplasms / diagnosis. Nerve Sheath Neoplasms / genetics. RNA, Messenger / analysis. RNA, Neoplasm / analysis. Sarcoma, Ewing / diagnosis. Sarcoma, Ewing / genetics. Skin / cytology

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  • (PMID = 15614524.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / RNA, Messenger; 0 / RNA, Neoplasm
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54. Dobashi Y, Suzuki S, Sato E, Hamada Y, Yanagawa T, Ooi A: EGFR-dependent and independent activation of Akt/mTOR cascade in bone and soft tissue tumors. Mod Pathol; 2009 Oct;22(10):1328-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • To gain the insight into the involvement of signaling mediated by the mammalian target of rapamycin (mTOR) in the phenotype and biological profiles of tumors and tumor-like lesions of the bone and soft tissue, we analyzed the expression and phosphorylation (activation) of mTOR and its correlation with the status of upstream and downstream modulator proteins Akt, p70S6-kinase (S6K), and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), which we refer to collectively as mTOR cassette proteins.
  • Immunohistochemical analysis of 140 cases showed activation of Akt in 55% (61% in malignant and 27% in benign), and mTOR expression in 61% (66% in malignant and 39% in benign).
  • The preponderance of mTOR activation was found in tumors of peripheral nerve sheath (malignant peripheral nerve sheath tumor and schwannoma), skeletal muscle origin (rhabdomyosarcoma), and in those exhibiting epithelial nature (chordoma and synovial sarcoma).
  • We conclude that mTOR-mediated signaling proteins function not only in the proliferation of the tumor cells, but also in the differentiation and/or maintenance of morphological phenotypes in tumors of rhabdomyoblastic and nerve sheath cell origin.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / analysis. Bone Neoplasms / enzymology. Phosphoproteins / analysis. Protein Kinases / analysis. Proto-Oncogene Proteins c-akt / analysis. Receptor, Epidermal Growth Factor / analysis. Ribosomal Protein S6 Kinases, 70-kDa / analysis. Signal Transduction. Soft Tissue Neoplasms / enzymology
  • [MeSH-minor] Cell Proliferation. Enzyme Activation. Humans. Immunoblotting. Immunohistochemistry. Mutation. Neoplasm Staging. Phosphorylation. Prognosis. TOR Serine-Threonine Kinases

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  • (PMID = 19648884.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / EIF4EBP1 protein, human; 0 / Phosphoproteins; EC 2.7.- / Protein Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.1 / Ribosomal Protein S6 Kinases, 70-kDa
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55. Ronaghy A, Yaar R, Goldberg LJ, Mahalingam M, Bhawan J: Perineural involvement: what does it mean? Am J Dermatopathol; 2010 Jul;32(5):469-76
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  • Perineural invasion is an important mechanism for local spread in certain malignant cutaneous neoplasms and is associated with aggressive tumor growth, increased frequency of recurrence, and increased morbidity and mortality.
  • There exists, however, a limited number of cutaneous and noncutaneous benign neoplasms in addition to reactive lesions that either demonstrates perineural involvement or mimics it.
  • Given the association of the term "invasion" with malignant neoplasms, we use the term "perineural involvement" to describe neoplastic cells of any type infiltrating within nerves.
  • Despite the presence of perineural involvement in these benign lesions, there is no evidence of aggressive behavior compared with similar examples which do not demonstrate perineural involvement.
  • The aim of this article is to review cutaneous and noncutaneous benign neoplasms and reactive conditions that may demonstrate or mimic perineural involvement.
  • Recognition of the spectrum of benign processes that may resemble perineural involvement may help prevent diagnostic confusion, misdiagnosis, and overly aggressive treatment.
  • [MeSH-major] Neoplasms / pathology. Nerve Sheath Neoplasms / pathology. Peripheral Nerves / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Neoplasm Invasiveness. Soft Tissue Neoplasms / mortality. Soft Tissue Neoplasms / pathology

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  • (PMID = 20526173.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 79
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56. Rekhi B, Bhatnagar D, Bhatnagar A, Saxena S: Cytomorphological study of soft tissue neoplasms: role of fluorescent immunocytochemistry in diagnosis. Cytopathology; 2005 Oct;16(5):219-26

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytomorphological study of soft tissue neoplasms: role of fluorescent immunocytochemistry in diagnosis.
  • RESULTS: Among the 30 cases in the present study, unaided cytological diagnoses ranged from 'spindle cell' tumour in four (13.3%) cases, benign and malignant spindle cell tumour in 17 (56.6%) cases, to malignant mesenchymal tumour in nine (30%) cases.
  • FICC helped in further correct categorization of 25/30 (83.3%) cases viz. leiomyoma (three), benign neurogenic tumour (six), schwannoma (one), dermatofibrosarcoma protuberans (three), synovial sarcoma (two), rhabdomyosarcoma (two), malignant fibrous histiocytoma (five) and malignant peripheral nerve sheath tumour (three).
  • [MeSH-major] Neoplasm Proteins. Soft Tissue Neoplasms / pathology

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  • (PMID = 16181307.001).
  • [ISSN] 0956-5507
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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57. Akin M, Bozkirli B, Leventoglu S, Unal K, Kapucu LO, Akyurek N, Sare M: Liver schwannoma incidentally discovered in a patient with breast cancer. Bratisl Lek Listy; 2009;110(5):298-300
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Benign schwannomas, also referred to as neurilemomas, neurinomas, and perineural fibroblastomas, are encapsulated nerve sheath tumors.
  • An USG-guided biopsy was performed and the histo-pathological examination revealed a "peripheral nerve sheath tumor".
  • The tumor resected from the liver was 5 x 4 x 3 cm, yellowish, soft, and capsulated tumor.
  • The tumor was diagnosed as benign liver schwannoma.
  • CONCLUSION: Schwannomas are benign, encapsulated neoplasms.
  • Symptoms and signs vary depending on the anatomical site and the size of the neoplasm; however, most schwannomas present as an asymptomatic or painless mass.
  • [MeSH-major] Breast Neoplasms. Carcinoma, Ductal, Breast. Liver Neoplasms. Neoplasms, Multiple Primary. Neurilemmoma


58. Coco DP, Hirsch MS, Hornick JL: Smoothelin is a specific marker for smooth muscle neoplasms of the gastrointestinal tract. Am J Surg Pathol; 2009 Dec;33(12):1795-801
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Smoothelin is a specific marker for smooth muscle neoplasms of the gastrointestinal tract.
  • The purpose of this study was to determine whether immunostaining for smoothelin could help distinguish smooth muscle neoplasms from their morphologic mimics, particularly KIT-negative gastrointestinal stromal tumors (GISTs), desmin-positive GISTs, and desmoid fibromatosis.
  • A total of 150 mesenchymal neoplasms of the GI tract, abdominal cavity, and retroperitoneum were retrieved from consult and surgical pathology archives, including 54 GISTs (8 KIT-negative; 13 desmin-positive), 17 GI leiomyosarcomas (LMS), 11 GI mural leiomyomas, 13 leiomyomas of the muscularis mucosae, 12 gastric schwannomas, 15 inflammatory myofibroblastic tumors, 9 cases of mesenteric desmoid fibromatosis, 10 dedifferentiated liposarcomas, and 9 malignant peripheral nerve sheath tumors.
  • Cytoplasmic expression of smoothelin was present in all 24 (100%) benign smooth muscle tumors (mural leiomyomas and leiomyomas of the muscularis mucosae).
  • None of the GISTs, desmoid tumors, inflammatory myofibroblastic tumors, schwannomas, dedifferentiated liposarcomas, or malignant peripheral nerve sheath tumors showed cytoplasmic reactivity for smoothelin.
  • Nuclear expression of smoothelin was not detected in any of the other tumor types examined.
  • In summary, diffuse cytoplasmic staining for smoothelin is highly sensitive and specific for benign leiomyomas of the GI tract.
  • These findings suggest that the extent and pattern of smoothelin expression may help differentiate between benign and malignant mesenchymal tumors of the GI tract, and may be useful in distinguishing leiomyomas from KIT-negative and/or desmin-positive GISTs.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cytoskeletal Proteins / analysis. Gastrointestinal Neoplasms / chemistry. Muscle Proteins / analysis. Smooth Muscle Tumor / chemistry
  • [MeSH-minor] Cell Differentiation. Cell Nucleus / chemistry. Cytoplasm / chemistry. Desmin / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Neoplasm Staging. Predictive Value of Tests. Proto-Oncogene Proteins c-kit / analysis. Sensitivity and Specificity

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  • (PMID = 19950405.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cytoskeletal Proteins; 0 / Desmin; 0 / Muscle Proteins; 0 / SMTN protein, human; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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59. Prabhakar S, Messerli SM, Stemmer-Rachamimov AO, Liu TC, Rabkin S, Martuza R, Breakefield XO: Treatment of implantable NF2 schwannoma tumor models with oncolytic herpes simplex virus G47Delta. Cancer Gene Ther; 2007 May;14(5):460-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of implantable NF2 schwannoma tumor models with oncolytic herpes simplex virus G47Delta.
  • Schwannomas are benign tumors composed of dedifferentiated Schwann cells that form along peripheral nerves causing nerve compression often associated with pain and loss of function.
  • Current surgical therapy involves total or subtotal surgical removal of the tumor, which may cause permanent nerve damage.
  • In the present study, we explore an alternate means of therapy in which schwannomas are injected with a replication-conditional herpes simplex virus (HSV) vector to shrink the tumor through cell lysis during virus propagation.
  • [MeSH-minor] Animals. Cell Line, Tumor. Gene Deletion. Humans. Mice, Inbred Strains. Neoplasm Transplantation

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  • (PMID = 17304235.001).
  • [ISSN] 0929-1903
  • [Journal-full-title] Cancer gene therapy
  • [ISO-abbreviation] Cancer Gene Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
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60. Prayson RA, Yoder BJ, Barnett GH: Epidermal growth factor receptor is not amplified in schwannomas. Ann Diagn Pathol; 2007 Oct;11(5):326-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Both neurofibromas and schwannomas are capable of progression to malignant peripheral nerve sheath tumors (MPNSTs).
  • The mitogenic signaling for schwannomas is unlikely to be related to overexpression or amplification of EGFR; however, acquiring this signaling pathway might contribute to the progression of a subset of benign peripheral nerve sheath tumors to MPNST.
  • [MeSH-major] Nerve Sheath Neoplasms / metabolism. Neurilemmoma / metabolism. Receptor, Epidermal Growth Factor / metabolism
  • [MeSH-minor] Adult. Aged. DNA, Neoplasm / genetics. Disease Progression. Female. Gene Amplification. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Male. Middle Aged

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  • (PMID = 17870017.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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61. Alves DA, Bell TM, Benton C, Rushing EJ, Stevens EL: Giant thoracic schwannoma in a rhesus macaque (Macaca mulatta). J Am Assoc Lab Anim Sci; 2010 Nov;49(6):868-72

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The multilobulated cystic and necrotic neoplasm was composed of interlacing streams and fascicles of neoplastic spindle cells arranged in Antoni A, and less commonly, Antoni B patterns.
  • The neoplasm was encapsulated mostly, and histomorphologic features were benign.
  • Immunohistochemistry indicated that neoplastic cells were positive for vimentin, S100, glial fibrillary acidic protein, and nerve growth factor receptor.
  • The histologic features and results of the immunohistochemical stains confirmed peripheral nerve origin and were consistent with schwannoma.
  • [MeSH-major] Macaca mulatta. Monkey Diseases / pathology. Neurilemmoma / veterinary. Thoracic Neoplasms / veterinary

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  • (PMID = 21205456.001).
  • [ISSN] 1559-6109
  • [Journal-full-title] Journal of the American Association for Laboratory Animal Science : JAALAS
  • [ISO-abbreviation] J. Am. Assoc. Lab. Anim. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2994058
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62. Wang Y, Kang L, Xiao L: Infrequent bilateral orbital tumors and simulating lesions: the experience of a Chinese institute. Jpn J Ophthalmol; 2009 Nov;53(6):629-34

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: The number and percentage of lesions in each general category were leukemia lesions in eight patients (19.5%), metastatic tumors in seven (17%), optic nerve and meningeal tumors in six (14.6%), secondary tumors in six (14.6%), peripheral nerve lesions in four (9.8%), inflammatory lesions in four (9.8%), and vasculogenic, histiocytic, and miscellaneous lesions, each in two patients (4.9%).
  • Of all cases, 51.2% were benign and 48.8% were malignant.
  • Of the 15 patients with either metastatic tumors or blood disorders, two (13.3%) had a history of primary neoplasm at presentation.
  • [MeSH-major] Orbital Neoplasms / epidemiology

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  • (PMID = 20020243.001).
  • [ISSN] 1613-2246
  • [Journal-full-title] Japanese journal of ophthalmology
  • [ISO-abbreviation] Jpn. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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63. Shintaku M, Arimoto A, Sakita N: Serous cystadenocarcinoma of the pancreas. Pathol Int; 2005 Jul;55(7):436-9
MedlinePlus Health Information. consumer health - Pancreatic Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The tumor extensively involved the body and tail of the pancreas and contiguously invaded the spleen.
  • The histopathology of the tumor was similar to that of serous cystadenoma, but mild nuclear hyperchromatism and atypism were noted, and the neoplastic invasion of nerve fibers in the stroma was observed.
  • The present case is the second example of this kind of neoplasm that showed direct splenic invasion.
  • Because serous cystadenocarcinoma of the pancreas exhibits bland cytological features, diligent search for the invasion of the surrounding tissue or peripheral nerves is needed for the differentiation from its benign counterpart.
  • [MeSH-major] Cystadenocarcinoma, Serous / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. CA-125 Antigen / analysis. CA-19-9 Antigen. Carcinoembryonic Antigen / analysis. Humans. Immunohistochemistry. Matrix Metalloproteinase 1 / analysis. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 15982220.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / CA-125 Antigen; 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen; 0 / Tumor Suppressor Protein p53; EC 3.4.24.7 / Matrix Metalloproteinase 1
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64. Blacksin MF, White LM, Hameed M, Kandel R, Patterson FR, Benevenia J: Granular cell tumor of the extremity: magnetic resonance imaging characteristics with pathologic correlation. Skeletal Radiol; 2005 Oct;34(10):625-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor of the extremity: magnetic resonance imaging characteristics with pathologic correlation.
  • OBJECTIVE: The purpose of this study is to delineate the magnetic resonance (MR) appearance of a granular cell tumor (GrCT) of the extremity and to correlate the imaging appearance with the microscopic findings.
  • DESIGN AND PATIENTS: A retrospective review of five patients with a histopathologic diagnosis of GrCT and pre-operative MR imaging of the neoplasm was done.
  • RESULTS: The benign subtype of GrCT is usually isointense or brighter than muscle on T1-weighted sequences, round or oval in shape, superficial in location, and 4 cm or less in size.
  • On T2-weighted sequences, benign lesions may demonstrate a high peripheral signal, as well as a central signal intensity that is isointense to muscle or suppressed fat.
  • A significant stromal component in the tumor and, hypothetically, a ribbon-like arrangement of tumor cells may influence the signal intensity demonstrated on the T1 and T2-weighted sequences.
  • The malignant subtype may demonstrate signal intensity characteristics and invasion of adjacent structures often seen with other aggressive neoplasms; sizes larger than 4 cm and association with major nerve trunks can be seen.
  • CONCLUSION: Benign GrCT has imaging characteristics which may distinguish this tumor from other soft tissue neoplasms, as well as the malignant type of this tumor.
  • [MeSH-major] Foot Diseases / pathology. Granular Cell Tumor / pathology. Hand / pathology. Shoulder / pathology. Soft Tissue Neoplasms / pathology. Thigh / pathology

  • MedlinePlus Health Information. consumer health - Foot Injuries and Disorders.
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  • (PMID = 16003548.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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65. Sato K, Ueda Y, Miwa S, Yokogawa A, Ozaki M, Katsuda S: Low-grade malignant soft-tissue perineurioma: interphase fluorescence in situ hybridization. Pathol Int; 2008 Nov;58(11):718-22
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Perineuriomas are usually benign soft-tissue tumors that arise from perineurial cells of the peripheral nerve sheath.
  • This report describes a case of low-grade malignant perineurioma in a 60-year-old man who presented with a growing tumor on the dorsal side of his left wrist.
  • The tumor was surgically excised and showed no adhesion to the surrounding muscle and no continuity with nerves.
  • Histology indicated that the tumor contained hypercellular and hypocellular areas with spindle-shaped cells proliferating in storiform patterns or perivascular whorling.
  • On immunohistochemistry tumor cells were found to be positive for epithelial membrane antigen, glucose transporter protein 1, and claudin-1.
  • Approximately 18.4% of tumor nuclei were labelled for Ki-67.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Cell Nucleus / chemistry. Cell Nucleus / pathology. Chromosome Aberrations. Chromosomes, Human, Pair 13. Claudin-1. DNA, Neoplasm / analysis. Glucose Transporter Type 1 / analysis. Humans. In Situ Hybridization, Fluorescence. Ki-67 Antigen / analysis. Male. Membrane Proteins / analysis. Middle Aged. Mitosis. Mucin-1 / analysis. Treatment Outcome. Wrist / surgery

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  • (PMID = 18844938.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CLDN1 protein, human; 0 / Claudin-1; 0 / DNA, Neoplasm; 0 / Glucose Transporter Type 1; 0 / Ki-67 Antigen; 0 / Membrane Proteins; 0 / Mucin-1
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66. Thway K, Fisher C, Debiec-Rychter M, Calonje E: Claudin-1 is expressed in perineurioma-like low-grade fibromyxoid sarcoma. Hum Pathol; 2009 Nov;40(11):1586-90

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Perineurioma is a peripheral nerve sheath neoplasm, which is usually benign.
  • [MeSH-major] Biomarkers, Tumor / analysis. Fibrosarcoma / pathology. Membrane Proteins / biosynthesis. Nerve Sheath Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19540561.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CLDN1 protein, human; 0 / Claudin-1; 0 / Membrane Proteins; 0 / Mucin-1
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67. Schöniger S, Summers BA: Localized, plexiform, diffuse, and other variants of neurofibroma in 12 dogs, 2 horses, and a chicken. Vet Pathol; 2009 Sep;46(5):904-15

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In humans, neurofibroma and schwannoma are distinct entities within the group of benign peripheral nerve sheath tumors.
  • In the veterinary literature, these tumors are often classified together simply as benign peripheral nerve sheath tumors, and diagnostic criteria for their subclassification are not well established.
  • We describe peripheral nerve sheath tumors with microscopic, immunohistologic, and ultrastructural features similar to those in subtypes of human neurofibroma in 12 dogs, 2 horses, and 1 chicken.
  • The canine tumors were located in the skin, peripheral nerve, tongue, and large intestine.
  • The chicken was a mature white Leghorn chicken with an ocular neoplasm.
  • This investigation shows the existence of identical subtypes of neurofibroma in animals and humans and identifies similarities in tumor location and patient age between animals and humans.
  • This report will allow a more discriminating classification of benign peripheral nerve sheath tumors and probably has a bearing on epidemiology, pathogenesis and prognosis.

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  • (PMID = 19429995.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. National Toxicology Program: Toxicology and carcinogenesis studies of isoeugenol (CAS No. 97-54-1) in F344/N rats and B6C3F1 mice (gavage studies). Natl Toxicol Program Tech Rep Ser; 2010 Sep;(551):1-178
Hazardous Substances Data Bank. Isoeugenol .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Genetic toxicity tests were conducted in Salmonella typhimurium, Escherichia coli, cultured Chinese hamster ovary cells, and mouse peripheral blood erythrocytes.
  • The incidence of atrophy of olfactory nerve bundles was significantly increased in 600 mg/kg females.
  • Minimal to moderate atrophy of olfactory epithelial tissue and nerve bundles was observed in 600 mg/kg males and females.
  • Two male rats in the 300 mg/kg group had rare benign or malignant thymomas, while two other males in this group had rare mammary gland carcinomas.
  • There was a significant positive trend in the incidences of histiocytic sarcoma in females, and this neoplasm occurred in multiple tissues.
  • Frequencies of micronucleated erythrocytes were not increased in peripheral blood of male mice exposed to isoeugenol by gavage for 3 months; however, an increasing trend and a threefold increase in the 600 mg/kg group indicate a positive result for this test in female mice.
  • [MeSH-major] Eugenol / analogs & derivatives. Neoplasms, Experimental / chemically induced

  • Hazardous Substances Data Bank. EUGENOL .
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  • (PMID = 21372857.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 3T8H1794QW / Eugenol; 97-54-1 / isoeugenol
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69. Bień E, Stachowicz-Stencel T, Polczyńska K, Sierota D, Stefanowicz J, Szołkiewicz A, Drozyńska E, Birkholtz D, Izycka-Swieszewska E, Czauderna P, Kosiak W, Dubaniewicz M, Reiter M, Balcerska A: [Therapeutic difficulties in soft tissue sarcoma occurring in children with neurofibromatosis type 1 - own observations]. Med Wieku Rozwoj; 2008 Jan-Mar;12(1):477-84
MedlinePlus Health Information. consumer health - Soft Tissue Sarcoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neurofibromatosis type I (NF1) is one of the most common genetic disorders in man, predisposing to benign and malignant tumours.
  • The most common malignancies comprise nervous system tumours, less frequently soft tissue sarcomas (STS) and leukaemia - myelodysplasia syndrome.
  • Neurogenic tumours were diagnosed in three children (malignant peripheral nerve-sheath tumour in two and malignant triton tumour in one), while soft tissue sarcomas of rhabdomyosarcoma origin were found in two patients.
  • [MeSH-major] Neoplasms, Second Primary / therapy. Neurofibromatosis 1 / therapy. Sarcoma / therapy. Soft Tissue Neoplasms / therapy
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Child, Preschool. Female. Humans. Infant. Male. Neoplasm Staging. Prognosis. Treatment Outcome


70. Huszar M, Moldenhauer G, Gschwend V, Ben-Arie A, Altevogt P, Fogel M: Expression profile analysis in multiple human tumors identifies L1 (CD171) as a molecular marker for differential diagnosis and targeted therapy. Hum Pathol; 2006 Aug;37(8):1000-8
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Here we carried out an immunohistochemical survey of L1 expression in normal adults and in a broad range of benign and malignant tumors using monoclonal antibody L1-11A and the novel monoclonal antibody L1-14.10.
  • In normal tissues, L1 was expressed in the collecting tubules of adult tissues and pediatric kidney and in peripheral nerve bundles.
  • Nongynecological tumors expressing L1 comprised malignant melanoma, colon adenocarcinoma positive to chromogranin, clear-cell adenocarcinoma of the urinary bladder, pheochromocytoma, small cell lung carcinoma, and tumors of the nervous system.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Biomarkers, Tumor / metabolism. Genital Neoplasms, Female / metabolism. Isoantigens / metabolism. Membrane Glycoproteins / metabolism. Receptors, Cell Surface / metabolism
  • [MeSH-minor] Antibodies, Monoclonal / immunology. Cell Line, Tumor. Diagnosis, Differential. Female. Fluorescent Antibody Technique, Direct. GPI-Linked Proteins. Humans. Immunoenzyme Techniques. Male. Neutrophils / metabolism

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  • (PMID = 16867862.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / CD177 protein, human; 0 / GPI-Linked Proteins; 0 / Isoantigens; 0 / Membrane Glycoproteins; 0 / Receptors, Cell Surface
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71. Patil SB, Kale SM, Jaiswal S, Khare N: Schwannoma of upper eyelid: A rare differential diagnosis of eyelid swellings. Indian J Plast Surg; 2010 Jul;43(2):213-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Schwannoma is a relatively rare benign tumour of peripheral nerve origin.

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  • [Cites] Clin Experiment Ophthalmol. 2005 Aug;33(4):412-3 [16033357.001]
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  • (PMID = 21217985.001).
  • [ISSN] 1998-376X
  • [Journal-full-title] Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India
  • [ISO-abbreviation] Indian J Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3010787
  • [Keywords] NOTNLM ; Eyelid tumours / S-100 protein / Schwannoma / malignant eyelid tumours
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72. Dawamneh MF, Amra NK, Amr SS: Low grade fibromyxoid sarcoma: report of a case with fine needle aspiration cytology and histologic correlation. Acta Cytol; 2006 Mar-Apr;50(2):208-12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Low grade fibromyxoid sarcoma has been fully described histologically; however, the fine needle aspiration (FNA) cytologic findings are scantily defined, and the distinction from other benign and malignant soft tissue tumors can be difficult.
  • The excised tumor was well circumscribed, focally infiltrating the surrounding muscles.
  • The tumor cells were spindly, with fusiform, uniform nuclei.
  • The tumor cells were positive for vimentin, alpha-1-antitrypsin and lysozyme and negative for S-100, actin, desmin and CD34.
  • CONCLUSION: Although low grade fibromyxoid sarcoma is a rare neoplasm, it should be recognized and distinguished from other soft tissue tumors because of its low malignant potential.
  • The definitive FNA cytologic diagnosis can be challenging but is possible if the tumor is adequately sampled, with multiple passes from different areas.
  • All spindle cell tumors with myxoid changes, such as myxoid liposarcoma, myxofibrosarcoma, cellular myxoma, myxoid leiomyosarcoma and peripheral nerve sheath tumors, should be considered in the differential diagnosis.
  • [MeSH-major] Fibrosarcoma / diagnosis. Fibrosarcoma / pathology. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / pathology. Thoracic Neoplasms / diagnosis. Thoracic Neoplasms / pathology

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  • (PMID = 16610692.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. De Queiroz GF, Matera JM, Zaidan Dagli ML: Clinical study of cryosurgery efficacy in the treatment of skin and subcutaneous tumors in dogs and cats. Vet Surg; 2008 Jul;37(5):438-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Malignant lesions had 3 freeze-thaw cycles benign tumors, 2 cycles.
  • RESULTS: Tumor size ranged from 0.3 to 11 cm diameter with 28 (60%) being 0.3-1 cm; 8 (17%) 1.1-3 cm, and 11 (23%) >3.4 cm.
  • One malignant peripheral nerve sheath tumor recurred 7 months after cryosurgical treatment.
  • [MeSH-major] Cat Diseases / surgery. Cryosurgery / veterinary. Dog Diseases / surgery. Skin Neoplasms / veterinary. Wound Healing / physiology
  • [MeSH-minor] Animals. Cats. Dogs. Female. Male. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / veterinary. Prospective Studies. Remission Induction. Treatment Outcome

  • MedlinePlus Health Information. consumer health - Skin Cancer.
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  • (PMID = 18986310.001).
  • [ISSN] 1532-950X
  • [Journal-full-title] Veterinary surgery : VS
  • [ISO-abbreviation] Vet Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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