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1. Sandison A: Common head and neck cases in our consultation referrals: diagnostic dilemmas in inverted papilloma. Head Neck Pathol; 2009 Sep;3(3):260-2
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  • [Title] Common head and neck cases in our consultation referrals: diagnostic dilemmas in inverted papilloma.
  • The most common diagnostic dilemma for pathologists referring cases for second opinion is the recognition of low grade malignancy versus benign inverted papilloma at presentation and in lesions which recur.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Papilloma, Inverted / pathology
  • [MeSH-minor] Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Humans. Neoplasm Recurrence, Local / pathology. Neoplasms, Multiple Primary / pathology. Neoplasms, Second Primary / pathology

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  • (PMID = 20596982.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
  • [Other-IDs] NLM/ PMC2811634
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2. Bolzoni A, Pianta L, Farina D, Nicolai P: Benign myoepithelioma of the lacrimal gland: report of a case. Eur Arch Otorhinolaryngol; 2005 Mar;262(3):186-8
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  • [Title] Benign myoepithelioma of the lacrimal gland: report of a case.
  • A mass in the right lacrimal fossa was detected at MRI and turned out to be benign myoepithelioma of the lacrimal gland at the histopathological examination.
  • [MeSH-minor] Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Surgical Procedures, Operative / methods

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  • (PMID = 15138773.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 9
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3. Mack MG, Rieger J, Baghi M, Bisdas S, Vogl TJ: Cervical lymph nodes. Eur J Radiol; 2008 Jun;66(3):493-500
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  • The lymph node staging is a very important prognostic parameter for patients with presenting with head neck cancer and is influencing the selection of the different therapeutic strategies including surgery, chemotherapy, radiotherapy or a combination of them.
  • A spherical lymph node larger than 10mm is an indicator for a malignant node, whereas an oval shape and/or a fatty hilus are more benign signs.
  • But there are many limitations and different cut offs published in the literature, indicating that the size of a lymph node is not a reliable criteria for the assessment of lymph nodes in the head and neck region.
  • Today new high-resolution MRI sequences and the development of specific contrast agents are offering new possibilities in the diagnostic work-up of head and neck lymph nodes.
  • This is causing a signal decrease on T2-weighted MR images in benign lymph nodes after administration of USPIO's, whereas malignant lymph nodes do not show a significant signal decrease.
  • Based on the fact, that the size evaluation of lymph nodes in the head and neck has not changed during the last decade, this paper will mainly focus on MRI with new contrast agents and new techniques as diffusion weighted imaging (DWI).
  • [MeSH-major] Diagnostic Imaging. Head and Neck Neoplasms / pathology. Lymphatic Metastasis / diagnosis
  • [MeSH-minor] Contrast Media. Dextrans. Ferrosoferric Oxide. Humans. Iron. Lymph Nodes / pathology. Magnetite Nanoparticles. Neoplasm Invasiveness / diagnosis. Neoplasm Staging. Oxides. Prognosis

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  • (PMID = 18337039.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Magnetite Nanoparticles; 0 / Oxides; E1UOL152H7 / Iron; G6N3J05W84 / ferumoxides; K3R6ZDH4DU / Dextrans; XM0M87F357 / Ferrosoferric Oxide
  • [Number-of-references] 45
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4. Yazdani N, Khorsandi-Ashtiani M, Rabbani-Anari M, Bassam A, Kouhi A: Nasal vestibular huge keratoacanthoma: an unusual site. Pak J Biol Sci; 2009 Oct 15;12(20):1385-7
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  • Keratoacanthoma (KA) is a rapidly growing, low-grade neoplasm of pilo-sebaceous and hair follicle units which most often appears on the sun-exposed skin of the middle aged and older persons with multiple or localized occurrence.
  • This tumor is dome-shaped nodule with a central keratinous plug.
  • The etiology of this tumor is not obvious.
  • About 80% of the tumors occur on the face.
  • The histological features of the KA are often very similar to those of a cutaneous squamous cell carcinoma; however, the tumor structure usually provides a basis for their difference.
  • For a clinician and a pathologist it is important to consider a benign lesion like Keratoacanthoma (KA) in the differential diagnosis of ulcerated nasal lesions and pay attention to differ it from Squamous Cell Carcinoma (SCC) which has a different and aggressive management.


5. Marzo SJ, Zender CA, Leonetti JP: Facial nerve schwannoma. Curr Opin Otolaryngol Head Neck Surg; 2009 Oct;17(5):346-50
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  • PURPOSE OF REVIEW: The purpose of this review is to summarize the current literature on facial nerve schwannoma and make practical recommendations based on best practices for the management of this difficult but benign neoplasm.
  • The tumor is usually slow-growing and can involve multiple segments of the nerve.
  • As the tumor can involve multiple segments of the nerve, the surgeon attempting removal should be familiar with modern neurotological surgical techniques.

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  • (PMID = 19561500.001).
  • [ISSN] 1531-6998
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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6. Dutsch-Wicherek M, Tomaszewska R, Strek P, Wicherek L, Skladzien J: The analysis of RCAS1 and DFF-45 expression in nasal polyps with respect to immune cells infiltration. BMC Immunol; 2006 Mar 21;7:4
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  • BACKGROUND: Nasal polyp constitutes a benign growth process in the nasal and sinus mucosa.

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  • (PMID = 16551346.001).
  • [ISSN] 1471-2172
  • [Journal-full-title] BMC immunology
  • [ISO-abbreviation] BMC Immunol.
  • [Language] ENG
  • [Grant] United Kingdom / Wellcome Trust / / WL/ZKL/26/L
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / DNA fragmentation factor, human; 0 / EBAG9 protein, human; 0 / Proteins
  • [Other-IDs] NLM/ PMC1448183
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7. Koo BS, Lim HS, Lim YC, Yoon YH, Kim YM, Park YH, Rha KS: Occult contralateral carcinoma in patients with unilateral papillary thyroid microcarcinoma. Ann Surg Oncol; 2010 Apr;17(4):1101-5
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  • The frequency, pattern, and predictive factors for occult contralateral carcinoma in these patients were analyzed with respect to the following variables: age, gender, tumor size, multifocality of primary tumor, presence of perithyroidal invasion, lymphovascular invasion or capsular invasion, presence of central lymph node metastasis, and the presence of coexistent benign nodules in the contralateral lobe based on preoperative evaluation and final pathology.
  • In multivariate analysis, multifocality of the primary tumor (P = 0.026, odds ratio = 7.714) and the presence of coexistent benign nodule in the contralateral lobe by preoperative evaluation (P = 0.036, odds ratio = 3.500) were independent predictive factors for occult contralateral PTMC presence.
  • However, there were no significant differences between the presence of occult contralateral carcinomas and age, gender, tumor size, perithyroidal invasion, lymphovascular invasion, capsular invasion, central lymph node metastasis, and coexistent benign nodules by final pathology.
  • CONCLUSIONS: Based on our findings, total thyroidectomy, including the contralateral lobe, should be considered for the treatment of unilateral PTMC if it presents as a multifocal tumor in the unilateral lobe and/or if nodules are found in the contralateral lobe during preoperative evaluation.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Risk Factors. Treatment Outcome

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  • (PMID = 20066517.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Jang YW, Kim SG, Pai H, Park JW, Lee YC, Rotaru H: Sialolipoma: case report and review of 27 cases. Oral Maxillofac Surg; 2009 Jun;13(2):109-13
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  • INTRODUCTION: This article presents a patient with sialolipoma of the submandibular gland, a rare neoplasm, and reviews related literatures.
  • The most common site for the tumor was the parotid gland (17 cases, 60.7%), followed by the palate (four cases, 14.2%).
  • Histopathologically, a tumor was a benign lesion with proliferating lipocytes including scattered foci with a normal salivary gland tissue.
  • CONCLUSION: Sialolipoma is a rare benign neoplasm in the head and neck and it shows equal sex predilection.

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  • (PMID = 19347375.001).
  • [ISSN] 1865-1550
  • [Journal-full-title] Oral and maxillofacial surgery
  • [ISO-abbreviation] Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 16
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9. Gleason BC, Fletcher CD: Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential. Am J Surg Pathol; 2008 Mar;32(3):354-62
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  • [Title] Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential.
  • Benign fibrous histiocytoma (FH) is one of the most common mesenchymal neoplasms of the skin.
  • Deep benign FH is an uncommon and poorly recognized clinical subtype that arises in subcutaneous or deep soft tissue.
  • The most common anatomic location was the extremities (58%); the remainder arose on the head and neck (22%), trunk (11%), and in the deep soft tissue of the retroperitoneum, mediastinum, or pelvis (9%).
  • The tumors ranged from 0.5 to 25 cm in size (median, 3.0 cm) and were well circumscribed grossly and microscopically.
  • All tumors were composed of bland ovoid to spindle cells arranged in a storiform pattern with admixed lymphocytes.
  • Of the 37 patients for whom clinical follow-up was available (median, 40 mo), 8 (22%) had a local recurrence; in all 8 cases, the tumor had been marginally or incompletely excised.
  • The metastasizing tumors were large (6 and 9 cm) and 1 had tumor necrosis but they were otherwise histologically identical to the nonmetastasizing lesions.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Neoplasm Metastasis / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Actins / analysis. Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD34 / analysis. Child. Desmin / analysis. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mitosis. Necrosis. Neoplasm Recurrence, Local

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  • (PMID = 18300816.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD34; 0 / Desmin
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10. Kim E, Bae TS, Kwon Y, Kim TH, Chung KW, Kim SW, Ro J, Lee ES: Primary malignant teratoma with a primitive neuroectodermal tumor component in thyroid gland: a case report. J Korean Med Sci; 2007 Jun;22(3):568-71
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  • [Title] Primary malignant teratoma with a primitive neuroectodermal tumor component in thyroid gland: a case report.
  • Teratomas comprise the most common extragonadal germ cell tumors in childhood.
  • Most teratomas involving the thyroid are benign and occur in children.
  • We report a case of a 31-yr-old female with a huge neck mass.
  • She underwent total thyroidectomy with bilateral modified radical neck dissection, intensive chemotherapy and radiotherapy.
  • This is the first case, to our knowledge, of malignant thyroid teratoma with a exuberant primitive neuroectodermal tumor component in Korea.
  • [MeSH-major] Neuroectodermal Tumors, Primitive / complications. Neuroectodermal Tumors, Primitive / pathology. Teratoma / complications. Teratoma / pathology. Thyroid Gland / pathology
  • [MeSH-minor] Adult. Female. Head and Neck Neoplasms / pathology. Humans. Neoplasm Metastasis. Positron-Emission Tomography / methods. Thyroid Diseases / diagnosis. Thyroidectomy. Tomography, X-Ray Computed

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  • (PMID = 17596674.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2693658
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11. Lombardi D, Piccioni M, Farina D, Morassi ML, Nicolai P: Oncocytic carcinoma of the maxillary sinus: a rare neoplasm. Eur Arch Otorhinolaryngol; 2006 Jun;263(6):528-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oncocytic carcinoma of the maxillary sinus: a rare neoplasm.
  • Oncocytic neoplasms are tumors composed of oncocytes (i.e., epithelial cells with a large cytoplasm that is rich in mitochondria).
  • Most cases are benign and originate from the major salivary glands, while the minor salivary glands are rarely involved.
  • Biopsy was consistent with an unspecified salivary gland neoplasm.
  • A brief analysis of the literature was also accomplished in order to discuss treatment options and prognosis of this unusual neoplasm.

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  • (PMID = 16474973.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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12. Matsushima M, Asakura H, Sakamoto H, Horinaga M, Nakahira Y, Yanaihara H: Leiomyoma of the bladder presenting as acute urinary retention in a female patient: urodynamic analysis of lower urinary tract symptom; a case report. BMC Urol; 2010;10:13
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  • BACKGROUND: Most bladder tumors are derived from the urothelium.
  • Benign mesenchymal tumors are rare.
  • Leiomyoma of the bladder is the most common benign neoplasm.
  • [MeSH-minor] Female. Humans. Magnetic Resonance Imaging. Manometry. Middle Aged. Treatment Outcome. Urinary Bladder Neck Obstruction / etiology. Urologic Surgical Procedures / methods

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  • (PMID = 20684762.001).
  • [ISSN] 1471-2490
  • [Journal-full-title] BMC urology
  • [ISO-abbreviation] BMC Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2924335
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13. Mineva I, Gartner W, Hauser P, Kainz A, Löffler M, Wolf G, Oberbauer R, Weissel M, Wagner L: Differential expression of alphaB-crystallin and Hsp27-1 in anaplastic thyroid carcinomas because of tumor-specific alphaB-crystallin gene (CRYAB) silencing. Cell Stress Chaperones; 2005;10(3):171-84
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  • [Title] Differential expression of alphaB-crystallin and Hsp27-1 in anaplastic thyroid carcinomas because of tumor-specific alphaB-crystallin gene (CRYAB) silencing.
  • Expression of the small heat shock protein alphaB-crystallin in differentiated thyroid tumors has been described recently.
  • In this study, we investigated the molecular mechanisms that affect the expression of alphaB-crystallin in benign goiters (n = 7) and highly malignant anaplastic thyroid carcinomas (ATCs) (n = 3).
  • In contrast, considerable expression of Hsp27-1 in benign and malignant thyroid tissue was demonstrated.
  • Immunofluorescence analysis revealed no relevant topological differences between benign and malignant thyrocytes in the cytoplasmic staining of both proteins.
  • In conclusion, we demonstrate downregulation of alphaB-crystallin expression in highly dedifferentiated ATCs because of a tumor-specific transcription factor pattern.
  • [MeSH-minor] Animals. COS Cells. Cell Line, Tumor. Cloning, Molecular. DNA, Complementary / biosynthesis. Down-Regulation. Gene Silencing. Genes, Reporter. Goiter. HSP27 Heat-Shock Proteins. Heat-Shock Proteins / analysis. Heat-Shock Proteins / metabolism. Humans. Luciferases / genetics. Neoplasm Proteins / analysis. Neoplasm Proteins / metabolism. Oligonucleotide Array Sequence Analysis. Promoter Regions, Genetic. RNA, Messenger / metabolism. Tissue Extracts / chemistry. Tissue Extracts / genetics. Tissue Extracts / metabolism. Transfection. alpha-Crystallin B Chain

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  • (PMID = 16184762.001).
  • [ISSN] 1355-8145
  • [Journal-full-title] Cell stress & chaperones
  • [ISO-abbreviation] Cell Stress Chaperones
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CRYAB protein, human; 0 / DNA, Complementary; 0 / HSP27 Heat-Shock Proteins; 0 / HSPB1 protein, human; 0 / Heat-Shock Proteins; 0 / Intermediate Filament Proteins; 0 / Neoplasm Proteins; 0 / Nerve Tissue Proteins; 0 / RNA, Messenger; 0 / Repressor Proteins; 0 / TFCP2L1 protein, human; 0 / Tissue Extracts; 0 / Transcription Factors; 0 / alpha-Crystallin B Chain; EC 1.13.12.- / Luciferases; EC 2.7.- / Protein Kinases
  • [Other-IDs] NLM/ PMC1226015
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14. Armstrong WB, Ridgway JM, Vokes DE, Guo S, Perez J, Jackson RP, Gu M, Su J, Crumley RL, Shibuya TY, Mahmood U, Chen Z, Wong BJ: Optical coherence tomography of laryngeal cancer. Laryngoscope; 2006 Jul;116(7):1107-13
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  • This prospective study evaluated the ability of OCT to identify the characteristics of laryngeal cancer and measure changes in the basement membrane, tissue microstructure, and the transition zone at the edge of tumors.
  • MATERIALS AND METHODS: One hundred thirty-three patients underwent OCT examination during surgical endoscopy of the head and neck.
  • Tumor and adjacent transition zones were imaged along with uninvolved subsites.
  • A transition zone to uninvolved epithelium at the tumor periphery was also often observed.
  • In six studies, benign or premalignant processes were histologically confirmed.
  • [MeSH-minor] Aged. Aged, 80 and over. Basement Membrane / ultrastructure. Biopsy. Diagnosis, Differential. Female. Humans. Laryngoscopy. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 16826043.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Grant] United States / PHS HHS / / A 91717; United States / NIDCD NIH HHS / DC / DC 006026; United States / NIBIB NIH HHS / EB / EB 00293; United States / NCRR NIH HHS / RR / RR 01192; United States / NCRR NIH HHS / RR / RR00827
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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15. Ondik MP, Kang J, Bayerl MG, Bruno M, Goldenberg D: Teflon laryngeal granuloma presenting as laryngeal cancer on combined positron emission tomography and computed tomography scanning. J Laryngol Otol; 2009 May;123(5):575-8
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  • BACKGROUND: Positron emission tomography with 18F-fluorodeoxyglucose (18FDG) has been increasingly used in the diagnostic investigation of patients with neoplasms of the head and neck.
  • However, certain benign or inflammatory lesions can also accumulate 18F-fluorodeoxyglucose and lead to misdiagnosis.
  • METHOD: We present the case of a 48-year-old woman who was diagnosed with a laryngeal neoplasm on integrated positron emission tomography and computed tomography scanning, after a routine ultrasound demonstrated an enlarged thyroid nodule.

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  • (PMID = 18976510.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 9002-84-0 / Polytetrafluoroethylene
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16. O'Malley BW Jr, Weinstein GS: Robotic skull base surgery: preclinical investigations to human clinical application. Arch Otolaryngol Head Neck Surg; 2007 Dec;133(12):1215-9
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  • Based on the preclinical work, transoral robotic surgery (TORS) was then performed in February 2007 on 1 human patient with a parapharyngeal to infratemporal fossa cystic neoplasm as part of a large prospective human trial.
  • For the human surgical case, a TORS approach was evaluated on one side for a benign neoplasm.
  • PATIENTS: For the human clinical trial, a TORS approach was evaluated for a patient with a benign neoplasm of the parapharyngeal space and infratemporal fossa.
  • In the first known human surgical case, TORS was used to remove a parapharyngeal space and infratemporal fossa cystic neoplasm.

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  • (PMID = 18086962.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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17. Belcadhi M, Mani R, Harzallah M, Bouaouina N, Bouzouita K: [Nasopharyngeal angiofibroma with intracranial extension: situating the chemotherapy-radiotherapy association]. Cancer Radiother; 2008 Sep;12(5):385-8
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  • Nasopharyngeal angiofibroma is a locally aggressive, although histologically benign, vascular neoplasm.
  • This neoplasm accounts for 0.05% of head and neck tumours and affects almost exclusively male adolescents.
  • We discuss the relevance and outcome of the association chemotherapy-radiotherapy in the treatment of nasopharyngeal angiofibromas with a consistent intracranial extension (stage III B of Arch Otolaryngol Head Neck Surg 122 (2003) 122-129).
  • [MeSH-minor] Adult. Female. Humans. Neoplasm Invasiveness

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  • (PMID = 18339570.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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18. Mazzaferri EL: Management of low-risk differentiated thyroid cancer. Endocr Pract; 2007 Sep;13(5):498-512
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  • OBJECTIVE: To summarize the definitions of and management recommendations for low-risk thyroid cancer made by the American and European Thyroid Associations and synthesize this information with the recent literature, including systematic evaluations of tumor staging systems guiding therapy.
  • Tumor staging systems are too inaccurate to guide therapy.
  • Preoperatively diagnosed PTMC should be treated with total or near-total thyroidectomy, regardless of tumor size.
  • For very low-risk patients with unifocal PTMC smaller than 1 cm that is removed by chance during surgery to treat benign thyroid disease, lobectomy alone without 131I therapy may be sufficient therapy if there are no concerning histologic features and no tumor extension beyond the thyroid, metastases, history of head and neck irradiation, or positive family history--any of which requires total or near-total thyroidectomy and remnant ablation with 30 mCi.
  • [MeSH-minor] Cell Differentiation. Combined Modality Therapy. Humans. Incidence. Neoplasm Staging. Risk Factors

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  • (PMID = 17872353.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
  • [Number-of-references] 95
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19. Izzo L, Casullo A, Caputo M, Costi U, Guerrisi A, Stasolla A, Basso L, Marini M, De Toma G: Space occupying lesions of parotid gland. Comparative diagnostic imaging and pathological analysis of echo color/power Doppler and of magnetic resonance imaging. Acta Otorhinolaryngol Ital; 2006 Jun;26(3):147-53
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  • Aim of the study was to evaluate the role of echo color/power Doppler and magnetic resonance imaging in the diagnosis of space occupying parotid lesions, in the attempt to establish criteria for differential diagnosis between benign and malignant types.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Needle. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging

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  • (PMID = 17063984.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2639964
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20. Schmidt M, Dietlein M, Schröder U, Schicha H: False-positive uptake of I-131 in a laryngocele mimicking thyroid remnant after thyroidectomy for papillary thyroid carcinoma. Clin Nucl Med; 2006 Nov;31(11):716-7
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  • Radioiodine therapy revealed intense radioiodine uptake of the neck, which was interpreted as thyroid remnant tissue.
  • Follow-up whole-body scans with iodine-131 in hypothyroidism 3 months and 1 year after radioiodine therapy revealed focal uptake in the neck.
  • Computed tomography and gadolinium-enhanced MRI of the neck demonstrated an ovoid lesion in the larynx without gadolinium enhancement.
  • Further examination of the patient in the ear, nose and throat department confirmed the finding of a laryngocele and biopsies demonstrated benign tissue.
  • Follow-up whole-body scans with iodine-131 in hypothyroidism 3 years and after injection of rhTSH 5 years after radioiodine therapy reproduced the focal uptake in the neck.
  • [MeSH-major] Carcinoma, Papillary / radionuclide imaging. Iodine Radioisotopes. Laryngeal Diseases / radionuclide imaging. Neoplasm Recurrence, Local / radionuclide imaging. Thyroid Neoplasms / radionuclide imaging

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  • (PMID = 17053394.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 0 / Radiopharmaceuticals
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21. Lai JC, Tsai YL: Schwannoma of the auricle. B-ENT; 2010;6(4):281-3
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  • RESULTS: Schwannoma is a benign, encapsulated, slow-growing neoplasm.
  • Approximately 25-45% of all schwannomas occur in the head and neck, whereas schwannomas of the external ear are extremely uncommon, with only nine cases reported in the English literature since the first report in 1977.
  • Schwannoma should be considered in the evaluation of any tumour of the auricle.

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  • (PMID = 21302691.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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22. Kalish LH, Ng T, Kalnins I, Da Cruz MJ: Pseudogout mimicking an infratemporal fossa tumor. Head Neck; 2010 Jan;32(1):127-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pseudogout mimicking an infratemporal fossa tumor.
  • CONCLUSION: The clinical and radiological features of patients with tophaceous pseudogout frequently mimic those of a benign or malignant neoplasm of the infratemporal fossa, often resulting in more radical surgery.

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  • (PMID = 19283846.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Otoh EC, Johnson NW, Olasoji H, Danfillo IS, Adeleke OA: Salivary gland neoplasms in Maiduguri, north-eastern Nigeria. Oral Dis; 2005 Nov;11(6):386-91
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  • OBJECTIVE: To document the pattern of salivary gland neoplasia in Maiduguri, Nigeria.
  • RESULTS: The palatal (71.9%) and parotid (78.3%) glands were the most common minor and major salivary glands involved, with a benign-malignant ratio of 1:1 and 1.4:1, respectively.
  • Pleomorphic adenoma (44.3%) was the most common salivary gland neoplasm recorded.
  • Ectopic lesions (17.1%) were reported in the neck, nose and cervical nodes.
  • CONCLUSION: Pleomorphic adenoma and mucoepidermoid carcinoma were the most commonly reported benign and malignant neoplasia in this series.

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  • (PMID = 16269031.001).
  • [ISSN] 1354-523X
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Denmark
  • [Number-of-references] 30
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24. Kabukcuoglu F, Kabukcuoglu Y, Tanik C, Sakiz D, Karsidag S: Breast carcinoma metastasis in recurrent myxoid liposarcoma. Pathol Oncol Res; 2009 Sep;15(3):467-71
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  • Tumor to tumor metastasis is a rare, but well recognized entity, most commonly involving a carcinoma metastasis to a benign or low grade mesenchymal tumor.
  • The tumor recurred twice and was reexcised.
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols. Combined Modality Therapy. Fatal Outcome. Female. Humans. Immunohistochemistry. Mastectomy. Middle Aged. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Radiotherapy


25. Papaspyrou K, Rossmann H, Fottner C, Weber MM, Mann W, Lackner KJ, Helling K: Malignant paraganglioma caused by a novel germline mutation of the succinate dehydrogenase D-gene--a case report. Head Neck; 2008 Jul;30(7):964-9
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  • BACKGROUND: Paragangliomas of the head and neck are rare, mostly benign tumors.
  • The patient's father reportedly suffered from bilateral carotid body tumors.
  • There was no increased hormone production by the tumor.
  • [MeSH-minor] Adult. Biopsy, Needle. Genetic Predisposition to Disease. Humans. Immunohistochemistry. Male. Neoplasm Staging. Pedigree. Positron-Emission Tomography. Risk Assessment. Treatment Refusal

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  • (PMID = 18213727.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.3.99.1 / Succinate Dehydrogenase
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26. Pudszuhn A, Welzel C, Bloching M, Neumann K: Intralesional Cidofovir application in recurrent laryngeal papillomatosis. Eur Arch Otorhinolaryngol; 2007 Jan;264(1):63-70
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  • Recurrent laryngeal papillomatosis is a benign disease of the larynx often leading to organic and functional restrictions.
  • [MeSH-minor] Adult. Aged. Child, Preschool. Combined Modality Therapy. Female. Human papillomavirus 11 / isolation & purification. Human papillomavirus 6 / isolation & purification. Humans. Laryngeal Mucosa / pathology. Laryngeal Mucosa / virology. Laser Therapy. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Remission Induction

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  • (PMID = 17058091.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / Organophosphonates; 8J337D1HZY / Cytosine; JIL713Q00N / cidofovir
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27. Reid-Nicholson M, Iyengar P, Friedlander MA, Lin O: Fine needle aspiration biopsy of primary mucinous carcinoma of the skin: a case report. Acta Cytol; 2006 May-Jun;50(3):317-22
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  • BACKGROUND: Primary mucinous carcinoma of the skin is a rare neoplasm of sweat gland origin.
  • At the time of wide excision of the residual tumor, sentinel lymph node biopsy revealed a single focus of micrometastasis.
  • CONCLUSION: Cutaneous mucinous carcinoma is a tumor characterized by bland histocytologic features and abundant extracellular pools of mucin.
  • Numerous benign and malignant mucin-producing primary and secondary mimics exist, and immunohistochemistry offers limited benefits in differentiating them.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Head and Neck Neoplasms / pathology. Scalp. Skin / pathology. Skin Neoplasms / pathology

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  • (PMID = 16780028.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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28. Gallagher TQ, Derkay CS: Recurrent respiratory papillomatosis: update 2008. Curr Opin Otolaryngol Head Neck Surg; 2008 Dec;16(6):536-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE OF REVIEW: Recurrent respiratory papillomatosis (RRP) is the most common benign neoplasm of the larynx in children.
  • RECENT FINDINGS: Recent investigations have resulted in the following findings: more accurate prevalence estimates of human papilloma virus in women in the United States; correlation of socioeconomic status and disease severity; the malignant potential of human papilloma virus in head and neck cancer; the role of the host immune system in RRP; the efficacy of a vaccine preventing human papilloma virus; the emergence of pulsed dye laser and potassium-titanyl-phosphate laser as a therapy for RRP; the efficacy of cidofovir as an adjunctive therapy for RRP; and the role of cyclooxygenase-2 in the molecular biology of RRP.


29. Yang F, Jin C, Long J, Yu XJ, Xu J, Di Y, Li J, Fu de L, Ni QX: Solid pseudopapillary tumor of the pancreas: a case series of 26 consecutive patients. Am J Surg; 2009 Aug;198(2):210-5
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  • [Title] Solid pseudopapillary tumor of the pancreas: a case series of 26 consecutive patients.
  • OBJECTIVE: Solid pseudopapillary tumor (SPT) of the pancreas, which predominantly affects young women, is a relatively indolent entity with favorable prognosis.
  • Clinicopathologic factors were compared between benign and malignant cases to determine what features of the tumor could suggest malignant potential.
  • The neoplasm was localized in the pancreatic head/neck in 14 patients and in the body/tail in 12 patients.
  • All of the tumors-including 8 pancreaticoduodenectomies, 10 distal pancreatectomies, 6 local resections, 1 total pancreatectomy, and 1 central pancreatectomy-were resected successfully.
  • CONCLUSIONS: SPT is a rare neoplasm with low malignant potential.

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  • (PMID = 19268906.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Tinoco RC, Tinoco AC, El-Kadre LJ, Rios RA, Sueth DM, Pena FM: [Laparoscopic transhiatal esophagectomy: outcomes]. Arq Gastroenterol; 2007 Apr-Jun;44(2):141-4
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  • BACKGROUND: The laparoscopic transhiatal esophagectomy for benign or malignant disease is a complex operation associated with a high rate of morbidity and mortality.
  • In the last decade this procedure gained popularity and acceptance for treatment of the esophagus cancer and other benign diseases.
  • Sixty-four with malignant neoplasm of esophagus.
  • The stomach was pulled up to the neck by the posterior mediastinum.
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Staging. Treatment Outcome

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  • (PMID = 17962860.001).
  • [ISSN] 0004-2803
  • [Journal-full-title] Arquivos de gastroenterologia
  • [ISO-abbreviation] Arq Gastroenterol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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31. Haymart MR, Glinberg SL, Liu J, Sippel RS, Jaume JC, Chen H: Higher serum TSH in thyroid cancer patients occurs independent of age and correlates with extrathyroidal extension. Clin Endocrinol (Oxf); 2009 Sep;71(3):434-9
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  • Despite the rise in the benign subgroups, mean TSH was consistently higher in those with cancer vs. those without.
  • On multivariate analysis of high-risk features associated with poor prognosis, there was a significant association between higher TSH and extrathyroidal extension (P = 0.002), whereas there was no clear relationship with age, tumour size > 4 cm, and distant metastases.
  • [MeSH-minor] Adult. Age Factors. Aged. Cohort Studies. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Risk Factors. Young Adult

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  • (PMID = 19067720.001).
  • [ISSN] 1365-2265
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / T35 DK062709
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 9002-71-5 / Thyrotropin
  • [Other-IDs] NLM/ NIHMS778777; NLM/ PMC4852738
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32. Garcia-Bonafe MM, Campins MM, Redecilla PH: Malignant nodular hidradenoma on the scalp: report of a case with fine needle aspiration cytology features and histologic correlation. Acta Cytol; 2009 Sep-Oct;53(5):576-80
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  • BACKGROUND: Malignant nodular hidradenoma (MNH) is a malignant adnexal tumor of the eccrine sweat glands.
  • The histology is similar to that of benign nodular hidradenoma, but MNH shows an infiltrative and invasive pattern, necrosis and angiolymphatic invasion.
  • CONCLUSION: Rapid, accurate diagnosis of these tumors is important, particularly when they develop at sites where a metastatic process must be ruled out.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Biopsy, Fine-Needle. Head and Neck Neoplasms / pathology. Scalp / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Anaplasia. Cell Differentiation. Female. Giant Cells / pathology. Humans. Immunohistochemistry. Middle Aged. Necrosis. Neoplasm Invasiveness. Predictive Value of Tests

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  • (PMID = 19798887.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. Rauso R, Tartaro G, Gherardini G, Puglia F, Santagata M, Colella G: Recurrence of ameloblastoma in temporal area: primary treatment influences recurrence rate. J Craniofac Surg; 2010 May;21(3):887-91
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  • Ameloblastomas are benign odontogenic tumors but are locally aggressive, most commonly occurring in the mandible and in the third to fifth decade of life.
  • [MeSH-major] Ameloblastoma / surgery. Mandibular Neoplasms / surgery. Neoplasm Recurrence, Local / surgery

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  • (PMID = 20485075.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Laco J, Simáková E, Svobodová J, Ryska A: Recurrent mucinous carcinoma of skin mimicking primary mucinous carcinoma of parotid gland: a diagnostic pitfall. Cesk Patol; 2009 Jul;45(3):79-82
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  • The lateral parotidectomy specimen showed a poorly circumscribed gelatinous tumor measuring 15 mm in diameter within the parotid gland tissue.
  • Microscopically, the lesion featured large pools of mucin containing clusters of tumor cells with little atypia and low mitotic activity.
  • Immunohistochemically, the tumor cells showed expression of epithelial markers and of both estrogen and progesterone receptors.
  • Left lateral neck dissection revealed massive lymphogenous dissemination of the tumor.
  • Retrospective analysis of a skin biopsy from the same anatomic area performed 8 years prior to parotid neoplasm displayed a tumor with identical microscopic appearance and immunohistochemical profile (additionally performed) which was, however, misdiagnosed as a benign lesion.
  • The differential diagnostics of this rare tumor is discussed.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Head and Neck Neoplasms / pathology. Neoplasm Recurrence, Local / diagnosis. Parotid Neoplasms / diagnosis

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  • (PMID = 19764163.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Czech Republic
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35. Kawata R, Yoshimura K, Lee K, Araki M, Takenaka H, Tsuji M: Basal cell adenoma of the parotid gland: a clinicopathological study of nine cases--basal cell adenoma versus pleomorphic adenoma and Warthin's tumor. Eur Arch Otorhinolaryngol; 2010 May;267(5):779-83
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  • [Title] Basal cell adenoma of the parotid gland: a clinicopathological study of nine cases--basal cell adenoma versus pleomorphic adenoma and Warthin's tumor.
  • The aim of this study is to investigate the clinical and pathological characteristics of basal cell adenoma (BCA) and to compare the diagnosis/treatment of BCA with those of Warthin's tumor (WT) and pleomorphic adenoma (PA).
  • Among 192 patients with benign tumors of the parotid gland who underwent surgery, 9 had BCA.
  • All of these tumors showed a benign pattern on computed tomography and magnetic resonance imaging.
  • Considering the gender difference, tumor site, and age, it is necessary to differentiate BCA from PA rather than from WT.
  • BCA is the third most common of the benign parotid tumors, following WT and PA, although its incidence is low.
  • When PA and WT are ruled out by FNAB after a tentative diagnosis of benign tumor has been based on imaging findings, BCA should be considered.
  • [MeSH-minor] Adult. Aged. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Time Factors

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  • (PMID = 19908055.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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36. Khandekar MM, Kavatkar AN, Patankar SA, Bagwan IB, Puranik SC, Deshmukh SD: FNAC of salivary gland lesions with histopathological correlation. Indian J Otolaryngol Head Neck Surg; 2006 Jul;58(3):246-8
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  • To evaluate utility of FNAC in salivary gland lesions.Back ground: Salivary gland lesions form about 2-6.5% of all head and neck neoplasms in adults.
  • They are easily accessible for FNAC (Fine Needle Aspiration Cytology) and risks of fistula formation or tumour implantation are low compared surgical biopsy.
  • Also, cytology can provide a distinction between asalivary and non salivary lesion, benign and malignant lesions so also specific and non specific inflammation.
  • RESULTS: 80% of the lesions were neoplastic (61% benign, 31% malignant) and 20% were neoplastic.
  • Pleomorphic adenoma was the most frequent benign neoplasm while mucoepidermoid carcinoma was the most frequent malignant lesion.

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  • (PMID = 23120304.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450424
  • [Keywords] NOTNLM ; FNAC / Salivary Gland / Salivary Gland Tumours
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37. Wang CP, Chang YL, Ko JY, Cheng CH, Yeh CF, Lou PJ: Desmoid tumor of the head and neck. Head Neck; 2006 Nov;28(11):1008-13
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  • [Title] Desmoid tumor of the head and neck.
  • BACKGROUND: [corrected] Desmoid tumors are rare benign tumors but have a tendency toward local recurrence after resection because of their infiltrative growth and frequent entrapment of vital structures in the head and neck region.
  • We report 24 desmoid tumors of the head and neck and propose a reasonable approach in the management of such cases.
  • METHODS: Twenty-four patients (9 male and 15 female; median age, 33 years; range, 0-66 years) with a desmoid tumor of the head and neck (neck, 15 patients; head, 9 patients) treated from 1990 to 2004 were retrospectively analyzed.
  • In the neck, 8 tumors were around the superficial layer of deep cervical fascia, whereas 4 tumors of the neck involved the prevertebral fascia and 2 involved brachial plexus.
  • RESULTS: Twenty patients received complete resection of the tumor, but the section margin was positive in 8 patients, of which 6 patients remained free of disease in a period of 13 to 105 months.
  • Two patients underwent partial resection of the tumor because of brachial plexus involvement.
  • The hypopharygneal tumor in a newborn had spontaneously complete regression, and tracheostomy was closed at the age of 6 years.
  • One patient remained with stable disease for 14 months after biopsy of the tumor without excision.
  • Surgical resection of the tumor with close observation is suggested even if the section margin is positive.
  • If a desmoid tumor cannot be removed grossly, regression or arrested growth of the remaining tumor is expected.
  • Radiotherapy might be reserved for a growing tumor.
  • [MeSH-major] Fibromatosis, Aggressive / surgery. Head and Neck Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Infant. Infant, Newborn. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Radiotherapy, Adjuvant. Retrospective Studies

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  • (PMID = 16983695.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Cheah WK, Rauff A, Lee KO, Tan W: Parathyroid carcinoma: a case series. Ann Acad Med Singapore; 2005 Aug;34(7):443-6
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  • One patient presented with osteitis fibrosa, 1 with renal stone and a neck mass, and 1 with recurrence of PHPT after excision of supposedly benign parathyroid adenoma 4 years ago.
  • Exploration of the neck clearly identified 1 parathyroid tumour with local invasion; 2 other specimens showed capsular and vascular invasion on frozen section and final histology.
  • No patient had tumour recurrence after a follow-up period of 1 year.
  • Suspicious features include marked hypercalcaemia, neck mass, and local recurrence.
  • Parathyroidectomy with ipsilateral hemithyroidectomy and nodal clearance gives the best chance of reducing local tumour recurrence.
  • [MeSH-minor] Adult. Biopsy, Needle. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Parathyroidectomy / methods. Risk Assessment. Treatment Outcome

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  • (PMID = 16123819.001).
  • [ISSN] 0304-4602
  • [Journal-full-title] Annals of the Academy of Medicine, Singapore
  • [ISO-abbreviation] Ann. Acad. Med. Singap.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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39. Roarke MC, Nguyen BD: Fat hypertrophy in a pharyngeal reconstruction flap presenting as an enlarging neck mass: demonstration of benign changes with PET/CT. Clin Nucl Med; 2006 Jan;31(1):48-9
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  • [Title] Fat hypertrophy in a pharyngeal reconstruction flap presenting as an enlarging neck mass: demonstration of benign changes with PET/CT.
  • The patient is a 73-year-old man with a history of radioresistant recurrent squamous cell carcinoma of the larynx, treated with total laryngectomy/pharyngectomy and rectus abdominis deep inferior epigastric perforator flap reconstruction, who presented with a painless enlarging neck mass.
  • Physical examination revealed increased neck bulk and fiberoptic nasopharyngolaryngoscopy was negative.
  • The clinician was concerned about underlying recurrent neoplasm or adenopathy displacing the flap outward and referred the patient for PET/CT.


40. Alix T, Labbé D, Caquant L, Comoz F, Compère JF, Bénateau H: [Management of whole-scalp tumour: the Poncet-Spiegler cylindroma or turban tumour]. Rev Stomatol Chir Maxillofac; 2009 Apr;110(2):109-12
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  • [Title] [Management of whole-scalp tumour: the Poncet-Spiegler cylindroma or turban tumour].
  • INTRODUCTION: The Poncet-Spiegler cylindroma (PSC) is a benign annexal cutaneous tumor which preferentially develops on the scalp, neck, or forehead.
  • When the scalp is completely involved, it presents as a "turban tumor".
  • Treatment is surgery and may be difficult when the tumor is extended.
  • We report the management of turban tumor.
  • DISCUSSION: As for most tumors, management depends on the size of the PSC.
  • In case of turban tumor, total scalp exeresis and secondary reconstruction with a skin graft is recommended.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Head and Neck Neoplasms / surgery. Scalp / surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Adult. Esthetics. Female. Follow-Up Studies. Humans. Neoplasm Recurrence, Local / surgery. Reconstructive Surgical Procedures. Skin Transplantation / methods

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  • (PMID = 19328506.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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41. Durden FL Jr, Moore CE, Muller S: Verrucous carcinoma of the paranasal sinuses: a case report. Ear Nose Throat J; 2010 Jul;89(7):E21-3
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  • Verrucous carcinoma is a low-grade variant of squamous cell carcinoma reported to occur in all anatomic sites in the head and neck region, most commonly the oral cavity.
  • The tumor grows locally invasive but is histologically benign and metastasizes rarely.
  • [MeSH-minor] Biopsy. Endoscopy. Humans. Male. Middle Aged. Nasal Cavity / pathology. Nasal Cavity / radiation effects. Nasal Cavity / surgery. Neoplasm Invasiveness. Neoplasm Staging. Orbital Neoplasms / pathology. Orbital Neoplasms / radiotherapy. Orbital Neoplasms / surgery. Skull / pathology. Skull / radiation effects. Skull / surgery. Skull Neoplasms / pathology. Skull Neoplasms / radiotherapy. Skull Neoplasms / surgery

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  • (PMID = 20628974.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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42. Coutinho-Camillo CM, Brentani MM, Nagai MA: Genetic alterations in juvenile nasopharyngeal angiofibromas. Head Neck; 2008 Mar;30(3):390-400
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  • Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign neoplasm of the nasopharynx that accounts for 0.5% of all head and neck tumors.
  • Although histologically benign in appearance, JNAs are locally aggressive and destructive, spreading from the nasal cavity to the nasopharynx, paranasal sinuses, and orbit skull base with intracranial extension.
  • Hormonal disorders have been reported in patients with JNA, and androgen and estrogen receptors have been identified in tumor tissue; however, a hormonal influence on JNA is controversial.
  • Understanding of the molecular mechanisms involved in JNA might improve prevention, prognosis, and treatment of this tumor.

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  • [Copyright] (c) 2008 Wiley Periodicals, Inc. Head Neck, 2008.
  • (PMID = 18228521.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Intercellular Signaling Peptides and Proteins; 0 / RNA, Messenger; 0 / Receptors, Steroid; 0 / beta Catenin; EC 2.5.1.18 / Glutathione Transferase
  • [Number-of-references] 103
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43. Lanza A, Moscariello A, Villani R, Colella G: Glomus tumor of the lower lip. A case report. Minerva Stomatol; 2005 Nov-Dec;54(11-12):687-90
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  • [Title] Glomus tumor of the lower lip. A case report.
  • A glomus tumor is a benign neoplasm originating from the modified smooth muscle cells of the vascular glomus.
  • This neoplasm was firstly considered by Masson in 1924, and generally it has a solitary lesions but in some cases multiple lesions were described.
  • The clinical case of a 65-year-old man with a glomus tumor of the lower lip is described.
  • [MeSH-major] Glomus Tumor / pathology. Lip Neoplasms / pathology

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  • (PMID = 16456522.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng; ita
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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44. Münz M, Zeidler R, Gires O: The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABP. Cancer Lett; 2005 Jul 8;225(1):151-7
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  • [Title] The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABP.
  • The epithelial cell adhesion molecule, EpCAM, is a transmembrane glycoprotein associated with both benign and malignant proliferation.
  • In cancer cells, expression levels of this tumour-associated antigen correlate positively with the grade of dysplasia and are also a negative prognostic factor for breast cancer patients.
  • Additionally, E-FABP levels correlated with the amount of EpCAM in permanent squamous cell carcinoma lines and in vivo in primary head and neck carcinomas.
  • Taken together, these results provide further evidence for the direct involvement of EpCAM in signalling processes, gene regulation, and cellular metabolism supporting its important role in tumour biology.
  • [MeSH-major] Antigens, Neoplasm / physiology. Carcinoma, Squamous Cell / genetics. Cell Adhesion Molecules / physiology. Gene Expression Regulation, Neoplastic
  • [MeSH-minor] Antigens, Differentiation. Carrier Proteins. Cell Proliferation. Epithelial Cells. Fatty Acid-Binding Proteins. Fatty Acids. Genes, myc. Humans. Proteome. Signal Transduction. Tumor Cells, Cultured. Up-Regulation

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  • (PMID = 15922867.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antigens, Differentiation; 0 / Antigens, Neoplasm; 0 / Carrier Proteins; 0 / Cell Adhesion Molecules; 0 / EPCAM protein, human; 0 / FABP5 protein, human; 0 / Fatty Acid-Binding Proteins; 0 / Fatty Acids; 0 / Proteome
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45. Ozcan C, Apaydin FD, Görür K, Apa DD: Peripheral giant cell granuloma of the mandibular condyle presenting as a preauricular mass. Eur Arch Otorhinolaryngol; 2005 Mar;262(3):178-81
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  • Central GCG (CGCG) is an uncommon benign fibro-osseous lesion generally presenting as an expansible mass with cortical bone defect.
  • The brown tumor of hyperparathyroidism and giant cell tumor must be ruled out because of the microscopic similarities of these lesions.
  • [MeSH-minor] Adult. Biopsy, Needle. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Tomography, X-Ray Computed

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  • (PMID = 15133683.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
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46. Lin D, Kashani-Sabet M, McCalmont T, Singer MI: Neurotropic melanoma invading the inferior alveolar nerve. J Am Acad Dermatol; 2005 Aug;53(2 Suppl 1):S120-2
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  • BACKGROUND: Desmoplastic neurotropic melanoma (DNM) and neurotropic melanoma (NM), rare lesions of the head and neck, often present as a benign-appearing nodule which later progresses to cranial nerve involvement.
  • [MeSH-major] Cranial Nerve Neoplasms / secondary. Lip Neoplasms / pathology. Mandibular Nerve. Melanoma / pathology. Neoplasm Recurrence, Local. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Male. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 16021159.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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47. Kohl SK, Simpson RJ, Wisecarver J: Chondroid metaplasia mimicking recurrent squamous cell carcinoma of the head and neck. Ear Nose Throat J; 2009 Jan;88(1):E4
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  • [Title] Chondroid metaplasia mimicking recurrent squamous cell carcinoma of the head and neck.
  • She had a history of squamous cell carcinoma of the head and neck that had been treated with surgery and radiotherapy 11 years earlier.
  • The tongue lesion was excised, and pathologic examination identified a submucosal focus of benign-appearing cartilage.
  • Chondroid metaplasia involving the head and neck is rare.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Neoplasm Recurrence, Local / pathology. Tongue Neoplasms / secondary. Tonsillar Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy, Needle. Cartilage / pathology. Combined Modality Therapy. Diagnosis, Differential. Female. Follow-Up Studies. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / therapy. Humans. Immunohistochemistry. Metaplasia / pathology. Neck Dissection / methods. Radiotherapy, Adjuvant. Risk Assessment. Tonsillectomy / methods

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  • (PMID = 19172559.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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48. do Nascimento KC, de Faria PR, Dib LL, Ferreira de Aguiar MC, Cardoso SV, Chen J, Loyola AM: Immunohistochemical localization of the NM23 protein in salivary gland neoplasms with distinct biological behavior. Virchows Arch; 2006 Dec;449(6):660-6
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  • To evaluate the role of NM23 in SGN, the expression patterns of NM23 in the following were compared: benign (pleomorphic adenoma) vs malignant (adenoid cystic carcinoma and mucoepidermoid carcinoma) SGN, and primary malignancies with/without evidence of metastasis vs their metastatic implants (MI).
  • NM23 protein was found in the cytoplasm of 75% of benign SGN, 73.3% of primary SGN malignancies with no evidence of metastasis, 86.6% of primary SGN malignancies with evidence of metastasis, and 60% of MI.
  • There was no statistically significant difference in the frequency of NM23-positive cells between benign and primary malignant tumors (p = 0.79), nor between primary malignancies with/without evidence of metastasis and MI (p = 0.51).
  • [MeSH-minor] Humans. Immunohistochemistry. NM23 Nucleoside Diphosphate Kinases. Neoplasm Metastasis

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  • (PMID = 17091257.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / NM23 Nucleoside Diphosphate Kinases; EC 2.7.4.6 / NME1 protein, human; EC 2.7.4.6 / Nucleoside-Diphosphate Kinase
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49. Kambham N, Kong C, Longacre TA, Natkunam Y: Utility of syndecan-1 (CD138) expression in the diagnosis of undifferentiated malignant neoplasms: a tissue microarray study of 1,754 cases. Appl Immunohistochem Mol Morphol; 2005 Dec;13(4):304-10
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  • However, it has not been widely tested in non-hematolymphoid tissues, and thus its utility in the setting of an undifferentiated malignant neoplasm has not been evaluated.
  • The authors conducted an extensive study of CD138 staining in over 1,700 normal, benign, and malignant non-hematolymphoid tissues, using five tissue microarrays.
  • In addition to the specific membrane staining, many normal tissues and epithelial tumors showed strong cytoplasmic immunoreactivity.
  • In squamous cell carcinoma of the head and neck, renal cell carcinoma, and prostate adenocarcinoma, the intensity of CD138 staining inversely correlated with the histologic grade of the carcinoma.
  • The authors conclude that the expression of syndecan-1, although relatively specific to plasma cells within the hematolymphoid system, should be interpreted with extreme caution in the setting of an undifferentiated neoplasm.
  • Furthermore, the two commercially available monoclonal CD138 antibodies tested in this study showed significant differences in their immunoreactivity in different tumor types.

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  • (PMID = 16280658.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Glycoproteins; 0 / Proteoglycans; 0 / SDC1 protein, human; 0 / Syndecan-1; 0 / Syndecans
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50. Tiwari P, Tripathi A, Vijay M, Mitra B, Kumar S, Pal DK, Kundu AK: Inverted papilloma of the urinary bladder: Rigorous surveillance needed? An Indian experience. Indian J Cancer; 2010 Oct-Dec;47(4):418-23
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  • AIMS: Inverted papilloma (IP) is an uncommon benign neoplasm of the urinary tract.
  • No patient had a synchronous or previous bladder tumor.
  • All were solitary tumors except one, most commonly found at the bladder neck and trigone.
  • CONCLUSIONS: We conclude that when diagnosed by strictly defined criteria, IP as benign urothelial neoplasm was with extremely low incidence of recurrence and good prognosis.

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  • (PMID = 21131756.001).
  • [ISSN] 1998-4774
  • [Journal-full-title] Indian journal of cancer
  • [ISO-abbreviation] Indian J Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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51. Liu FH, Hsueh C, Chao TC, Lin JD: Neck nodule and thyroid cancer in young without radiation exposure history. Pediatr Surg Int; 2009 Sep;25(9):785-8
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  • [Title] Neck nodule and thyroid cancer in young without radiation exposure history.
  • PURPOSE: The aim of this study was to analyze the results of histopathological studies in neck masses observed in young patients.
  • The neck masses were detected using ultrasonography and fine-needle aspiration cytology (FNAC).
  • METHODS: In this retrospective study, we analyzed 234 young patients who were surgically treated for neck masses at Chang Gung Medical Center in Linkou.
  • Neck ultrasonography studies were conducted using a real-time ultrasonographic machine and a 10 MHz transducer.
  • FNAC was performed for the suspected neck nodules.
  • RESULTS: Of the 234 cases, 187 (79.9%) were surgically confirmed to be benign lesions, including four cases that were diagnosed as atypical adenoma.
  • CONCLUSIONS: In the study population, 20.1% of the neck masses were malignant.
  • Except in cases of follicular thyroid neoplasm, neck ultrasonography with FNAC could effectively identify the thyroid or non-thyroid origin of these masses with high-diagnostic accuracy.
  • [MeSH-major] Head and Neck Neoplasms / pathology
  • [MeSH-minor] Adenoma / pathology. Adolescent. Biopsy, Fine-Needle. Carcinoma / pathology. Child. Child, Preschool. Cysts / pathology. Female. Hemangioma, Capillary / pathology. Humans. Infant. Lymphoma / pathology. Male. Neck / diagnostic imaging. Neurofibroma / pathology. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity. Thyroiditis / pathology. Ultrasonography. Young Adult

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  • (PMID = 19629501.001).
  • [ISSN] 1437-9813
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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52. Sanabria A, Carvalho AL, Piana de Andrade V, Pablo Rodrigo J, Vartanian JG, Rinaldo A, Ikeda MK, Devaney KO, Magrin J, Augusto Soares F, Ferlito A, Kowalski LP: Is galectin-3 a good method for the detection of malignancy in patients with thyroid nodules and a cytologic diagnosis of "follicular neoplasm"? A critical appraisal of the evidence. Head Neck; 2007 Nov;29(11):1046-54
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  • [Title] Is galectin-3 a good method for the detection of malignancy in patients with thyroid nodules and a cytologic diagnosis of "follicular neoplasm"? A critical appraisal of the evidence.
  • Immunostaining of cytological smears from FNAB with galectin-3 has been proposed as a tool for differentiating between benign and malignant nodules.
  • METHODS: Prospective studies of nodules with FNAB reports of "follicular neoplasm" and with a definitive diagnosis confirmed by histopathology were selected.
  • CONCLUSION: Galectin-3 could be a good tool to guide therapeutic decision in patients with thyroid nodules and FNAB results of follicular neoplasm, but available information has methodological flaws that precludes a definitive answer about galectin-3 utility in the clinical setting.

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  • (PMID = 17525969.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Galectin 3
  • [Number-of-references] 68
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53. Sarda AK, Kapur MM: Thyroid surgery in an area of iodine deficiency. Head Neck; 2005 May;27(5):383-9
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  • The indications for surgery were hyperthyroidism or cytologically diagnosed malignancy and large size, pressure symptoms, cosmesis, suspicious cytologic findings for malignancy, and clinical suspicion of malignancy in clinically benign euthyroid goiters.
  • RESULTS: Histologically, 83 of 703 solitary thyroid nodules, 36 of 329 clinically benign euthyroid multinodular goiters, and four of 181 Graves' disease were cancers.
  • [MeSH-minor] Adenocarcinoma, Follicular / epidemiology. Adenocarcinoma, Follicular / surgery. Adenocarcinoma, Papillary / epidemiology. Adenocarcinoma, Papillary / surgery. Adult. Female. Follow-Up Studies. Humans. India / epidemiology. Lymphatic Metastasis. Male. Neoplasm Recurrence, Local / epidemiology. Retrospective Studies. Thyroidectomy / adverse effects. Thyroidectomy / methods. Thyrotropin / blood

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  • Hazardous Substances Data Bank. IODINE, ELEMENTAL .
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  • [Copyright] 2005 Wiley Periodicals, Inc.
  • (PMID = 15772954.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9002-71-5 / Thyrotropin; 9679TC07X4 / Iodine
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54. Laskin WB, Fetsch JF, Lasota J, Miettinen M: Benign epithelioid peripheral nerve sheath tumors of the soft tissues: clinicopathologic spectrum of 33 cases. Am J Surg Pathol; 2005 Jan;29(1):39-51
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  • [Title] Benign epithelioid peripheral nerve sheath tumors of the soft tissues: clinicopathologic spectrum of 33 cases.
  • Benign epithelioid peripheral nerve sheath tumors (BEPNSTs) have not been fully characterized, and their relationship to conventional schwannoma and neurofibroma has not been satisfactorily established.
  • The tumors were predominantly dermal/subcutaneous in location (85%) and involved the lower limb (n=15), upper limb (n=11), trunk (n=4), and head/neck (n=3).
  • Microscopically, the tumors were generally well-circumscribed, uninodular, or multinodular masses.
  • Tumors consisted of trabeculae, loosely arranged nodules, and cohesive nests of epithelioid tumor cells immersed in collagenous, myxohyaline, or chiefly myxoid stroma.
  • A bland spindled cell component comprising 5% to 40% of the tumor was noted in 15 cases.
  • Immunohistochemical reactivity for Schwann cell-related markers in tumor cells included S-100 protein (20 of 20 cases), collagen type IV (10 of 10), laminin (8 of 8), nerve growth factor receptor, p75(7 of 8), CD57 (6 of 9), and glial fibrillary acidic protein (8 of 15).
  • Anti-epithelial membrane antigen highlighted perineurial cells in 9 of the 11 encapsulated tumors.
  • Anti-neurofilament protein did not identify intralesional neuraxons in the 10 tumors evaluated.
  • Eighteen tumors were subtyped as epithelioid neurofibromas.
  • Follow-up for 18 patients (median interval, 13.5 years), including 4 patients with tumors exhibiting cytologic atypia, revealed a nondestructive recurrence or persistent disease in 3 patients whose tumors lacked atypia, but no evidence of metastatic spread or tumor-related death.
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Child. Child, Preschool. DNA, Neoplasm / analysis. Female. Humans. Immunoenzyme Techniques. Loss of Heterozygosity. Male. Middle Aged. Mitotic Index. Neurofibromin 1 / genetics. Neurofibromin 1 / metabolism. Neurofibromin 2 / genetics. Neurofibromin 2 / metabolism. Polymerase Chain Reaction

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  • (PMID = 15613855.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Neurofibromin 1; 0 / Neurofibromin 2
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55. Nazir SA, Raza SA, Nazir S, Sherwood W, Bowker C, Lakhoo K: Challenges in the prenatal and post-natal diagnosis of mediastinal cystic hygroma: a case report. J Med Case Rep; 2008;2:256
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  • INTRODUCTION: Cystic hygroma is a benign congenital neoplasm that mostly presents as a soft-tissue mass in the posterior triangle of the neck.

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56. Saussez S, Mahillon V, Blaivie C, Haller A, Chantrain G, Thill MP: Aggressive pilomatrixoma of the infra-auricular area: a case report. Auris Nasus Larynx; 2005 Dec;32(4):407-10
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  • Although pilomatrixomas are well known among dermatologists and dermatopathologists, head and neck surgeons confronted with these lesions in the infra-auricular region do not consider this benign neoplasm in the differential diagnosis.
  • Aggressive pilomatrixoma is a benign tumor of the hair matrix cells affecting mainly children.
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Humans. Male. Neoplasm Staging

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  • (PMID = 16198080.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 13
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57. Hirono S, Yamaue H: Middle pancreatectomy for pancreatic neoplasms. J Hepatobiliary Pancreat Sci; 2010 Nov;17(6):803-7
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  • BACKGROUND: A middle pancreatectomy (MP) is a parenchyma-preserving procedure for benign or low-malignant neoplasms in the neck or body of the pancreas that reduces long-term endocrine and exocrine insufficiency.
  • CONCLUSIONS: MP is a safe procedure for the treatment of benign or low-grade malignant neoplasms in the pancreatic neck or body, and in this procedure, the postoperative endocrine and exocrine functions are well preserved.
  • [MeSH-minor] Humans. Neoplasm Staging. Suture Techniques. Treatment Outcome

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  • (PMID = 19907916.001).
  • [ISSN] 1868-6982
  • [Journal-full-title] Journal of hepato-biliary-pancreatic sciences
  • [ISO-abbreviation] J Hepatobiliary Pancreat Sci
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
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58. Ferlito A, Devaney KO, Rinaldo A: Primary carcinoid tumor of the middle ear: a potentially metastasizing tumor. Acta Otolaryngol; 2006 Mar;126(3):228-31
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  • [Title] Primary carcinoid tumor of the middle ear: a potentially metastasizing tumor.
  • The concept of a carcinoid tumor in the gastrointestinal tract and lung is well established; less often, patients develop carcinoid tumors in the head and neck region.
  • One particularly uncommon site of origin of carcinoid tumors in the head and neck area is the middle ear.
  • Middle ear carcinoids have previously been approached as benign entities, lacking any capacity for metastasizing.
  • A critical review of the literature, however, disclosed a small number of cases in which middle ear carcinoid tumors have given rise to regional (cervical node) metastases.
  • This in turn suggests that, as is the case with pulmonary carcinoid tumors, middle ear carcinoids should be thought of as low-grade malignancies which, while relatively slow-growing, nevertheless possess a limited capacity for spreading to regional lymph nodes.
  • To date, distant metastases have not been associated with middle ear carcinoid tumors.
  • [MeSH-major] Carcinoid Tumor / secondary. Ear Neoplasms / pathology. Ear, Middle. Lymphatic Metastasis / pathology. Neoplasm Invasiveness / pathology
  • [MeSH-minor] Biopsy, Needle. Female. Humans. Immunohistochemistry. Male. Neoplasm Staging. Prognosis. Risk Assessment. Survival Rate. Treatment Outcome

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  • (PMID = 16618645.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Norway
  • [Number-of-references] 21
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59. Abdulla AN, Covert AA, Grantmyre JE: Scrotal syringocystadenoma papilliferum: case report. Can J Urol; 2009 Jun;16(3):4684-6
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  • Syringocystadenoma papilliferum (SCAP) is a benign rare adnexal skin neoplasm, which in a third of cases arises from a nevus sebaceous and is most commonly found on the head and neck and in very rare instances found on the genitalia.

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  • (PMID = 19497181.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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60. Strobel K, Haerle SK, Stoeckli SJ, Schrank M, Soyka JD, Veit-Haibach P, Hany TF: Head and neck squamous cell carcinoma (HNSCC)--detection of synchronous primaries with (18)F-FDG-PET/CT. Eur J Nucl Med Mol Imaging; 2009 Jun;36(6):919-27
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  • [Title] Head and neck squamous cell carcinoma (HNSCC)--detection of synchronous primaries with (18)F-FDG-PET/CT.
  • PURPOSE: The aim of the study was to evaluate (18)F-FDG-PET/CT for the detection of synchronous primaries at initial staging of patients with head and neck squamous cell carcinoma (HNSCC).
  • Of the 56 second cancers, 46 (82%) were found in the aerodigestive tract in the following locations: lung (26, 46%), head and neck (15, 17%), oesophagus (5, 9%).
  • Nine synchronous cancers were not detected by PET/CT (four head and neck, two lung, two oesophageal, one gastric).
  • False-positive PET/CT findings were mainly related to benign FDG uptake in the intestine due to benign or precancerous polyps or physiological FDG uptake in other head and neck regions.
  • Synchronous cancers were predominantly located in the aerodigestive tract, primarily in the lung, head and neck and oesophagus.
  • [MeSH-major] Fluorodeoxyglucose F18. Head and Neck Neoplasms / diagnostic imaging. Neoplasms, Multiple Primary / diagnostic imaging. Neoplasms, Squamous Cell / diagnostic imaging
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. False Positive Reactions. Female. Humans. Male. Middle Aged. Neoplasm Staging. Neoplasms, Second Primary / diagnostic imaging. Neoplasms, Second Primary / pathology. Neoplasms, Second Primary / therapy. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 19205699.001).
  • [ISSN] 1619-7089
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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61. Stojadinovic A, Peoples GE, Libutti SK, Henry LR, Eberhardt J, Howard RS, Gur D, Elster EA, Nissan A: Development of a clinical decision model for thyroid nodules. BMC Surg; 2009;9:12
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  • Four to seven percent of the United States adult population (10-18 million people) has a palpable thyroid nodule, however the majority (>95%) of thyroid nodules are benign.
  • While, fine needle aspiration remains the most cost effective and accurate diagnostic tool for thyroid nodules in current practice, over 20% of patients undergoing FNA of a thyroid nodule have indeterminate cytology (follicular neoplasm) with associated malignancy risk prevalence of 20-30%.
  • Given that the majority (70-80%) of these patients have benign surgical pathology, thyroidectomy in these patients is conducted principally with diagnostic intent.

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  • (PMID = 19664278.001).
  • [ISSN] 1471-2482
  • [Journal-full-title] BMC surgery
  • [ISO-abbreviation] BMC Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Validation Studies
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2731077
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62. Scala WA, Fernandes AM, Duprat Ade C, Costa HO: Granular cell tumor of the larynx in children: a case report. Braz J Otorhinolaryngol; 2008 Sep-Oct;74(5):780-5
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  • [Title] Granular cell tumor of the larynx in children: a case report.
  • The granular cell tumor (GCT) is an uncommon neoplasm, with slow progression, usually benign, that can be found in any organ.
  • The most common region for GCT involvement is in the head and neck.
  • Among the major theories of origin and based on the strongest evidence, the most accepted one is that the tumor stems from neuronal tissue.
  • [MeSH-major] Granular Cell Tumor / pathology. Laryngeal Neoplasms / pathology

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  • (PMID = 19082363.001).
  • [ISSN] 1808-8694
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / S100 Proteins
  • [Number-of-references] 13
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63. Bhandarkar ND, Sims HS, David O: ProEx C stain analysis in recurrent respiratory papillomatosis. Ann Otol Rhinol Laryngol; 2010 Feb;119(2):99-104
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  • OBJECTIVES: We evaluated the presence and pattern of ProEx C stain, a marker for the proliferative capacity of cells, in laryngeal tissues, including benign, malignant, and recurrent respiratory papilloma (RRP) specimens, and compared it to hematoxylin and eosin staining for the presence of dysplasia.
  • RESULTS: A total of 26 specimens (9 benign, 7 malignant, 10 RRP) representing 21 patients were stained.
  • Seven of 9 benign and 7 of 10 RRP specimens stained positive.
  • The benign specimens were mostly polyps.
  • In benign and RRP specimens, the basal layer typically stained positive.
  • Other areas of epithelium stained weakly in benign specimens and variably in RRP specimens.
  • [MeSH-major] Antigens, Neoplasm / analysis. Cell Cycle Proteins / analysis. DNA Topoisomerases, Type II / analysis. DNA-Binding Proteins / analysis. Nuclear Proteins / analysis. Papilloma / chemistry. Respiratory Tract Neoplasms / chemistry
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biopsy. Cell Proliferation. Diagnosis, Differential. Humans. Immunohistochemistry. Isoenzymes. Minichromosome Maintenance Complex Component 2. Neoplasm Recurrence, Local

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  • (PMID = 20336920.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / DNA-Binding Proteins; 0 / Isoenzymes; 0 / Nuclear Proteins; EC 3.6.4.12 / MCM2 protein, human; EC 3.6.4.12 / Minichromosome Maintenance Complex Component 2; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
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64. Cohen SM, Burkey BB, Netterville JL: Surgical management of parapharyngeal space masses. Head Neck; 2005 Aug;27(8):669-75
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  • RESULTS: One hundred sixty-six PPS masses were identified: 21 (12.7%) were malignant, 145 (87.3%) were benign, 76 (45.8%) were vascular, and 69 (41.6 %) involved the skull base.
  • Removing the styloid and its musculature and level II lymphadenectomies enhanced exposure for vascular and skull base tumors.
  • Thirty transcervical-transmastoid dissections (20.4%) facilitated removal of vascular skull base tumors.
  • Expected neurologic sequelae resulted from cranial nerve involvement by tumor.
  • CONCLUSION: Careful patient assessment and surgical techniques allow the oncologically safe removal of benign, vascular, and skull base PPS tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Infant. Lymph Node Excision. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasms, Vascular Tissue / diagnosis. Neoplasms, Vascular Tissue / pathology. Neoplasms, Vascular Tissue / surgery. Paraganglioma / diagnosis. Paraganglioma / pathology. Paraganglioma / surgery. Retrospective Studies. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / pathology. Salivary Gland Neoplasms / surgery. Skull Base Neoplasms / diagnosis. Skull Base Neoplasms / pathology. Skull Base Neoplasms / surgery. Treatment Outcome

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  • [Copyright] Copyright 2005 Wiley Periodicals, Inc.
  • (PMID = 15880689.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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65. Franzmann EJ, Reategui EP, Pedroso F, Pernas FG, Karakullukcu BM, Carraway KL, Hamilton K, Singal R, Goodwin WJ: Soluble CD44 is a potential marker for the early detection of head and neck cancer. Cancer Epidemiol Biomarkers Prev; 2007 Jul;16(7):1348-55
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  • [Title] Soluble CD44 is a potential marker for the early detection of head and neck cancer.
  • INTRODUCTION: Head and neck squamous cell carcinoma (HNSCC) is a devastating and deadly disease, largely because it is diagnosed in late stage.
  • In this study, we evaluate soluble CD44 (solCD44) as an early detection tool for HNSCC by determining whether it reliably distinguishes HNSCC from benign disease of the upper aerodigestive tract.
  • METHODS: We carried out the solCD44 ELISA on oral rinses from 102 patients with HNSCC and 69 control patients with benign diseases of upper aerodigestive tract to determine the sensitivity and specificity of the test for differentiating HNSCC from benign disease.
  • Furthermore, we did a pilot study using methylation-specific PCR primers on oral rinses from 11 HNSCC patients with low solCD44 levels and 10 benign disease controls.
  • RESULTS: Mean salivary solCD44 levels were 24.4 +/- 32.0 ng/mL for HNSCC patients (range, 0.99-201 ng/mL) and 9.9 +/- 16.1 ng/mL (range, 0.73-124 ng/mL) for the patients with benign disease (P < 0.0001).
  • CONCLUSIONS: SolCD44 is elevated in the majority of HNSCC and distinguishes cancer from benign disease with high specificity.
  • [MeSH-major] Antigens, CD44 / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / metabolism. Head and Neck Neoplasms / metabolism
  • [MeSH-minor] Case-Control Studies. DNA Methylation. Enzyme-Linked Immunosorbent Assay. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Pilot Projects. Prognosis. Saliva / metabolism. Sensitivity and Specificity

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  • (PMID = 17627000.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA107828
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD44; 0 / Biomarkers, Tumor; 0 / CD44 protein, human
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66. Yilmaz AD, Unlu RE, Orbay H, Sensoz O: Recurrent granular cell tumor: how to treat. J Craniofac Surg; 2007 Sep;18(5):1187-9
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  • [Title] Recurrent granular cell tumor: how to treat.
  • Granular cell tumor is an uncommon lesion usually located in the head and neck region (50%) with a female sex predominance.
  • Granular cell tumor has a peculiar clinical behavior ranging from clearly benign, locally aggressive, or manifestly malignant.
  • In this article, we present a case of recurrent benign granular cell tumor with the discussion of the treatment modalities.
  • The patient was a 16-year-old girl with a 3-year history of a painless mass on the right side of her neck.
  • The mass was excised two times at different centers and diagnosed as granular cell tumor after the pathologic examination.
  • [MeSH-major] Granular Cell Tumor / pathology. Head and Neck Neoplasms / pathology. Neoplasm Recurrence, Local / pathology

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  • (PMID = 17912112.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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67. Upile T, Triaridis S, Kirkland P, Goldstraw P, Rhys Evans P: How we do it: the anterior thoraco-cervical approach to tumours of the thoracic inlet. Clin Otolaryngol; 2005 Dec;30(6):561-5
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  • KEYPOINTS: Tumours that arise in the thoracic inlet and superior mediastinum may be benign or malignant and present the surgeon with a difficult problem of access.
  • The anterior thoraco-cervical approach to the root of the neck and superior mediastinum combines the anterior cervical approach with a limited upper median sternotomy.
  • The approach offers excellent exposure and helps to facilitate complete resection of benign and malignant tumours, which would otherwise be deemed inoperable or difficult to resect completely through other standard approaches.
  • [MeSH-major] Neck / surgery. Thoracic Neoplasms / surgery. Thoracotomy / methods
  • [MeSH-minor] Chylothorax / etiology. Dissection. Follow-Up Studies. Humans. Mediastinal Neoplasms / surgery. Mediastinum / surgery. Neck Muscles / surgery. Neoplasm Metastasis. Neoplasm Recurrence, Local / surgery. Pleural Effusion / etiology. Postoperative Complications. Postoperative Hemorrhage / etiology. Sternum / surgery. Treatment Outcome

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  • (PMID = 16402986.001).
  • [ISSN] 1749-4478
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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68. Xu W, Wang HB, Cao HY, Fan ZM, Yue ZY, Lü ZH: [Recurrent laryngeal nerve decompression]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2006 Jun;41(6):408-11
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  • OBJECTIVE: To study the result of recurrent laryngeal nerve decompression in the treatment of functional disturbance of recurrent laryngeal nerve caused by thyroid surgery or thyroid benign tumors.
  • Seven cases of the nerve paralysis were caused by the surgery of benign thyroid tumors resection which were done by general surgeons.
  • One case of thyroid adenoma and 1 case of nodular goiter with unilateral recurrent laryngeal nerve paralysis were treated with tumor resection and nerve decompression respectively.
  • Four cases of glottic insufficiency, 3 cases of nodular goiter were treated with tumor resection and nerve decompression, and Hashimoto's thyroiditis in the other case was treated with partial lobe resection and nerve decompression.
  • For the functional disturbance of recurrent laryngeal nerve with thyroid neoplasm patient, early exploration and decompression of the nerve is imperative.

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  • (PMID = 16927793.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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69. Sakamoto K, Ono T, Nakamura Y, Harada H, Nakashima T: Expression of cluster of differentiation 9 glycoprotein in benign and malignant parotid gland tumours. J Laryngol Otol Suppl; 2009;(31):58-63
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  • [Title] Expression of cluster of differentiation 9 glycoprotein in benign and malignant parotid gland tumours.
  • Regarding benign parotid gland tumours, cluster of differentiation 9 glycoprotein was present in 13 of 18 pleomorphic adenomas, in all Warthin tumours tested (21/21) and in all cases of basal cell adenoma tested (four of four).
  • CONCLUSIONS: There was a statistically significantly reduced expression of cluster of differentiation 9 glycoprotein in malignant parotid gland tumours, compared with benign parotid gland tumours (p < 0.05).
  • [MeSH-major] Antigens, CD / analysis. Membrane Glycoproteins / analysis. Neoplasm Proteins / analysis. Parotid Gland / chemistry. Parotid Neoplasms / chemistry

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  • (PMID = 19460206.001).
  • [ISSN] 0144-2945
  • [Journal-full-title] The Journal of laryngology and otology. Supplement
  • [ISO-abbreviation] J Laryngol Otol Suppl
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD9; 0 / CD9 protein, human; 0 / Membrane Glycoproteins; 0 / Neoplasm Proteins
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70. Schache AG, Hall G, Woolgar JA, Nikolaidis G, Triantafyllou A, Lowe D, Risk JM, Shaw RJ, Liloglou T: Quantitative promoter methylation differentiates carcinoma ex pleomorphic adenoma from pleomorphic salivary adenoma. Br J Cancer; 2010 Dec 7;103(12):1846-51
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  • BACKGROUND: potential epigenetic biomarkers for malignant transformation to carcinoma ex pleomorphic adenoma (Ca ex PSA) have been sought previously with and without specific comparison with the benign variant, pleomorphic salivary adenoma (PSA).
  • We sought to demonstrate quantitative promoter methylation across a panel of tumour suppressor genes (TSGs) in both Ca ex PSA and PSA.
  • METHODS: quantitative methylation-specific real-time polymerase chain reaction (qMSP) analysis of p16(INK4A), CYGB, RASSF1, RARβ, human telomerase reverse transcriptase (hTERT), Wilms' tumour 1 (WT1) and TMEFF2 gene promoters was undertaken on bisulphite-converted DNA, previously extracted from archival fixed tissue specimens of 31 Ca ex PSA and an unrelated cohort of 28 PSA.
  • All target regions examined had formerly been shown to be hypermethylated in salivary and/or mucosal head and neck malignancies.
  • CONCLUSIONS: we demonstrate the successful application of qMSP to a large series of historical Ca ex PSA samples and report on a panel of TSGs with significant differences in their methylation profiles between benign and malignant variants of pleomorphic salivary adenoma. qMSP analysis could be developed as a useful clinical tool to differentiate between Ca ex PSA and its benign precursor.
  • [MeSH-minor] Genes, Tumor Suppressor. Humans. Membrane Proteins / genetics. Neoplasm Proteins / genetics. Polymerase Chain Reaction. Telomerase / genetics. WT1 Proteins / genetics

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  • [Copyright] 2010 Cancer Resaerch UK.
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  • (PMID = 21063414.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / TMEFF2 protein, human; 0 / WT1 Proteins; EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
  • [Other-IDs] NLM/ PMC3008600
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71. Pietniczka-Załeska M, Dabrowska-Bień J: [Parotid tumors: a two-year experience of Otolaryngology Department at MSS Hospital in Warsaw]. Otolaryngol Pol; 2009 Sep;63(7):43-6
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  • [Title] [Parotid tumors: a two-year experience of Otolaryngology Department at MSS Hospital in Warsaw].
  • THE AIM OF THE STUDY: Tumors of the salivary glands represent about 3% of head and neck neoplasms.
  • All of the patients had ultrasound examination prior to operation to estimate the spread and the type of the tumor.
  • RESULTS: The frequency of incidence of benign tumours was 90% and the most frequent histopathological diagnosis was pleomorphic adenoma (49%) and adenolymphoma (42%).
  • CONCLUSION: Superficial and total parotidectomy are safe procedures of treatment in case of salivary gland tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Follow-Up Studies. Hospitals, Special. Humans. Male. Middle Aged. Neoplasm Staging. Oral Surgical Procedures / statistics & numerical data. Poland. Retrospective Studies. Survival Analysis. Treatment Outcome. Young Adult

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  • (PMID = 20564899.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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72. Sabir Husin Athar PP, Yahya Z, Mat Baki M, Abdullah A: Facial nerve paralysis: a rare complication of parotid abscess. Malays J Med Sci; 2009 Apr;16(2):38-9
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  • Benign parotid neoplasm and inflammatory processes of the parotid resulting in facial paralysis are extremely rare.

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  • (PMID = 22589657.001).
  • [ISSN] 1394-195X
  • [Journal-full-title] The Malaysian journal of medical sciences : MJMS
  • [ISO-abbreviation] Malays J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
  • [Other-IDs] NLM/ PMC3336167
  • [Keywords] NOTNLM ; facial nerve injuries / neurosciences / parotid neoplasms / parotitis
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73. Chiesa F, Tradati N, Grigolato R, Boracchi P, Biganzoli E, Crose N, Cavadini E, Formelli F, Costa L, Giardini R, Zurrida S, Costa A, De Palo G, Veronesi U: Randomized trial of fenretinide (4-HPR) to prevent recurrences, new localizations and carcinomas in patients operated on for oral leukoplakia: long-term results. Int J Cancer; 2005 Jul 1;115(4):625-9
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  • In a controlled multicenter study, 170 patients operated on for oral leukoplakias with benign postoperative histology were randomized to 200 mg fenretinide daily for 1 year vs. no intervention.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Carcinoma / prevention & control. Fenretinide / therapeutic use. Leukoplakia, Oral / drug therapy. Mouth Neoplasms / drug therapy. Neoplasm Recurrence, Local / prevention & control

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15700313.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 187EJ7QEXL / Fenretinide
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74. Ducic Y, Oxford L, Pontius AT: Transoral approach to the superomedial parapharyngeal space. Otolaryngol Head Neck Surg; 2006 Mar;134(3):466-70
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  • METHODS: Eight patients with various neoplasms of the superomedial PPS were retrospectively reviewed for type of neoplasm, size, success with the transoral approach, need for conversion to another approach, length of hospitalization, and complications.
  • RESULTS: The transoral approach described herein safely allowed for en bloc resection of benign neoplasms with intraoperative control and exposure of the internal carotid artery.
  • Mean tumor size was 3.3 cm (range, 1.5 to 7 cm).
  • This technique is indicated for neoplasms with benign appearance on preoperative imaging or fine needle aspiration.
  • [MeSH-minor] Adolescent. Adult. Biopsy, Needle. Carotid Artery, Internal / pathology. Child. Female. Follow-Up Studies. Humans. Intraoperative Care. Length of Stay. Male. Middle Aged. Neoplasm Invasiveness. Neurilemmoma / pathology. Neurilemmoma / surgery. Postoperative Complications. Retrospective Studies. Teratoma / pathology. Teratoma / surgery. Treatment Outcome

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  • (PMID = 16500446.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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75. Logasundaram R, Amarawickrama H, Premachandra D, Hellquist H: Intracapsular (in situ) carcinoma ex pleomorphic adenoma with unusual clinical and histological features. Eur Arch Otorhinolaryngol; 2008 Dec;265(12):1563-6
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  • The first recurrence, after an interval of 8 years, showed only recurrence of the benign component.
  • This case report elucidates the atypical clinical behaviour and interesting histological features encountered within this group of salivary neoplasm.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma in Situ / pathology. Myoepithelioma / pathology. Neoplasm Recurrence, Local / pathology. Parotid Neoplasms / pathology

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  • (PMID = 18288478.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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76. Tan GC, Shiran MS, Swaminathan M, Phang KS, Rohaizak M: Large retrosternal parathyroid carcinoma with primary hyperparathyroidism. Asian J Surg; 2007 Oct;30(4):286-9
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  • Parathyroid carcinoma is an indolent tumour with rather low malignant potential.
  • Clinical indicators favouring parathyroid carcinoma over benign disease include markedly raised serum calcium levels, PTH and alkaline phosphatase.
  • A palpable neck mass with both kidney and skeletal manifestations also give a high index of suspicion of parathyroid carcinoma.

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  • (PMID = 17962134.001).
  • [ISSN] 1015-9584
  • [Journal-full-title] Asian journal of surgery
  • [ISO-abbreviation] Asian J Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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77. Wu J, Crimmins JT, Monk KR, Williams JP, Fitzgerald ME, Tedesco S, Ratner N: Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign world health organization grade I neurofibroma. Am J Pathol; 2006 May;168(5):1686-96
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  • [Title] Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign world health organization grade I neurofibroma.
  • Benign peripheral nerve tumors called neurofibromas are a major source of morbidity for patients with neurofibromatosis type 1.

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  • (PMID = 16651634.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS028840; United States / NCI NIH HHS / CA / T32 CA059268; United States / NINDS NIH HHS / NS / NS28840; United States / NCI NIH HHS / CA / T32-CA-59268
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 0 / Chemotactic Factors; 0 / Fibroblast Growth Factor 9; 0 / Neurofibromin 1; 0 / Oncogene Proteins v-fos; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 3.1.4.- / 2',3'-Cyclic-Nucleotide Phosphodiesterases; PQX0D8J21J / Cetuximab
  • [Other-IDs] NLM/ PMC1606591
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78. Koch M, Dimmler A, Alexiou C: [Recurrent and metastasizing atypical fibroxanthoma]. HNO; 2008 Oct;56(10):1046-51
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  • Atypical fibroxanthoma is a rare skin tumor that arises particularly on sun-exposed skin.
  • Although it is considered to be a benign tumor, rarely, metastases arise.
  • A complete tumor excision was performed, and the patient declined the recommended postoperative radiotherapy.
  • [MeSH-major] Ear Neoplasms / surgery. Histiocytoma, Benign Fibrous / surgery. Neoplasm Recurrence, Local / surgery. Parotid Neoplasms / secondary. Parotid Neoplasms / surgery

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  • (PMID = 18210006.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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79. Gurey LE, Brook CD, Parnes SM: Pleomorphic adenoma of the infratemporal fossa: case report and literature review. Laryngoscope; 2010;120 Suppl 4:S151
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  • OBJECTIVES: To describe an unusual location for a common benign salivary gland neoplasm.

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  • (PMID = 21225749.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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80. Fei Z, Zhang X, Jiang XF, Liu WP, Wang XL, Xie L: Removal of large benign cephalonasal tumours by transbasal surgery combined with endonasal endoscopic sinus surgery and neuronavigation. J Craniomaxillofac Surg; 2007 Jan;35(1):30-4
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  • [Title] Removal of large benign cephalonasal tumours by transbasal surgery combined with endonasal endoscopic sinus surgery and neuronavigation.
  • In 20 cases neuronavigation was used in addition to locate the tumour and adjoining structures.
  • RESULTS: Twenty-seven cases had a complete removal of the tumour whilst the others had only a subtotal resection.
  • CONCLUSION: Transbasal surgery combined with endonasal endoscopic sinus surgery and neuronavigation is a particularly useful technique for resecting large benign cephalonasal tumours.
  • [MeSH-major] Endoscopy / methods. Head and Neck Neoplasms / surgery. Neuronavigation / methods. Skull Base / surgery
  • [MeSH-minor] Abducens Nerve Diseases / etiology. Adolescent. Adult. Child. Child, Preschool. Deglutition Disorders / etiology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Nasal Cavity / surgery. Neoplasm Recurrence, Local / surgery. Neoplasm, Residual / pathology. Nose Neoplasms / surgery. Olfaction Disorders / etiology. Ophthalmoplegia / etiology. Paralysis / etiology. Paranasal Sinus Neoplasms / surgery. Radiotherapy, Adjuvant. Reoperation. Retrospective Studies. Skull Base Neoplasms / surgery

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  • (PMID = 17261369.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
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81. Kruse AL, Zwahlen RA, Grätz KW: New classification of maxillary ameloblastic carcinoma based on an evidence-based literature review over the last 60 years. Head Neck Oncol; 2009;1:31
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  • BACKGROUND: The ameloblastic carcinoma is a rare malignant odontogenic tumor which rather occurs in the mandible than in the maxilla.
  • Current classifications do not consider benign histopathological features at the primary and malignant features at the metastatic tumour site.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Evidence-Based Medicine. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 19674470.001).
  • [ISSN] 1758-3284
  • [Journal-full-title] Head & neck oncology
  • [ISO-abbreviation] Head Neck Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2733136
  • [General-notes] NLM/ Original DateCompleted: 20100629
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82. Domfeh AB, Fichera M, Hunt JL: Allelic loss of 3 different tumor suppressor gene loci in benign and malignant endothelial tumors of the head and neck. Arch Pathol Lab Med; 2006 Aug;130(8):1184-7
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  • [Title] Allelic loss of 3 different tumor suppressor gene loci in benign and malignant endothelial tumors of the head and neck.
  • CONTEXT: Angiosarcomas are rare malignancies that commonly arise in the head and neck.
  • OBJECTIVE: This study compared the molecular profile of angiosarcoma with that in some benign vascular lesions.
  • This supports the cell culture-based theories that tumorigenesis in endothelial cells likely involves these chromosomes and provides some insight into the potential pathogenesis of angiosarcomas and benign hemangiomas.
  • [MeSH-major] Genes, Tumor Suppressor. Head and Neck Neoplasms / genetics. Hemangioma / genetics. Hemangiosarcoma / genetics. Loss of Heterozygosity / genetics
  • [MeSH-minor] Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 13. Chromosomes, Human, Pair 17. DNA, Neoplasm / analysis. Endothelium, Vascular / pathology. Genes, Retinoblastoma. Genes, Wilms Tumor. Genes, p53. Genetic Markers. Granulation Tissue / pathology. Humans. Microdissection. Microsatellite Repeats / genetics


83. Abalo-Lojo JM, Cameselle-Teijeiro J, Gonzalez F: Pilomatrixoma: late onset in two periocular cases. Ophthal Plast Reconstr Surg; 2008 Jan-Feb;24(1):60-2
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  • First described by Malherbe and Chenantais in 1880, pilomatrixoma is a benign skin neoplasm that arises from hair follicle matrix cells.
  • Clinically, it manifests as a firm, solitary, slow growing, painless nodule of the dermis, more frequently located in the head, neck, and upper extremities.
  • It is typically a tumor of younger individuals and rarely presents in older patients.

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  • (PMID = 18209650.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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84. Gourin CG, Watts T, Williams HT, Patel VS, Bilodeau PA, Coleman TA: Identification of distant metastases with PET-CT in patients with suspected recurrent head and neck cancer. Laryngoscope; 2009 Apr;119(4):703-6
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  • [Title] Identification of distant metastases with PET-CT in patients with suspected recurrent head and neck cancer.
  • OBJECTIVES: To investigate the utility of positron-emission tomography/computed tomography (PET-CT) in identifying distant metastatic disease in patients with suspected recurrent head and neck squamous cell cancer (HNSCC).
  • There was a significant correlation between standardized uptake value (SUV) on PET-CT and positive histology, with a mean SUV of 8.5 (range, 4.7-16.2) in patients with distant metastases compared with a mean SUV of 2.9 (range, 1.9-4.2) in patients with benign pathology (r = 0.87, P < .0001).
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Female. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / surgery. Humans. Incidence. Male. Middle Aged. Neoplasm Recurrence, Local / radiography. Neoplasm Recurrence, Local / radionuclide imaging. Positron-Emission Tomography. Preoperative Care. Radiotherapy, Adjuvant. Retrospective Studies. Salvage Therapy. Sensitivity and Specificity. Tomography, X-Ray Computed

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  • (PMID = 19205017.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Folpe AL, Mentzel T, Lehr HA, Fisher C, Balzer BL, Weiss SW: Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature. Am J Surg Pathol; 2005 Dec;29(12):1558-75
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  • This family of tumors includes angiomyolipoma (AML), clear cell sugar tumor of the lung (CCST), lymphangioleiomyomatosis (LAM), and very rare tumors in other locations.
  • Sites of involvement included the omentum or mesentery (6 cases), uterus (4 cases), pelvic soft tissues (3 cases), abdominal wall (2 cases), uterine cervix (2 cases), and vagina, retroperitoneum, thigh, falciform ligament, scalp, broad ligament, forearm, shoulder, and neck (1 case each).
  • The tumors ranged from 1.6 to 29 cm in size (median, 7.8 cm).
  • Tumors were epithelioid (N = 9), spindled (N = 7), or mixed (N = 10).
  • Recurrence and/or metastasis was strongly associated tumor size > median size (8 cm), mitotic activity greater than 1/50 HPF, and necrosis.
  • We conclude that PEComas of soft tissue and gynecologic origin may be classified as "benign," "of uncertain malignant potential," or "malignant."
  • Small PEComas without any worrisome histologic features are most likely benign.
  • [MeSH-major] Biomarkers, Tumor / analysis. Epithelioid Cells / pathology. Genital Neoplasms, Female / pathology. Neoplasms, Connective and Soft Tissue / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Follow-Up Studies. Humans. Immunohistochemistry. Immunophenotyping. Male. Middle Aged. Mitosis. Neoplasm Metastasis. Neoplasm Recurrence, Local. Retrospective Studies. Survival Analysis. Time Factors. Treatment Outcome. Tumor Burden

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  • (PMID = 16327428.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 56
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86. Łapienis M, Kaczmarczyk D, Zimmer-Nowicka J, Niedźwiecka I, Jesionek-Kupnicka D, Morawiec-Bajda A: [Ameloblastoma of the maxillary sinus--a case report]. Otolaryngol Pol; 2008;62(6):784-6
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  • Ameloblastoma (adamantinoma) is a benign neoplasm deriving from the enamel organ.
  • It constitutes about 1% of all head and neck tumours, and about 11% of teeth-originating tumours.

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  • (PMID = 19205533.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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87. Hemandas AK, Robson NK, Hickish T, Talbot RW: Colorectal tubulovillous adenomas identified on fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography scans. Colorectal Dis; 2008 May;10(4):386-9
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  • CONCLUSION: Benign colonic polyps produce high-intensity focal FDG uptake in large bowel.
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Fluorodeoxyglucose F18. Gastrointestinal Neoplasms / pathology. Head and Neck Neoplasms / pathology. Humans. Lung Neoplasms / pathology. Male. Middle Aged. Neoplasm Staging / methods. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 17608754.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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88. Srinivasan K, Hariharan N, Parthiban P, Shyamala R: Lipoma of tongue - A rare site for a rare site for a common tumour. Indian J Otolaryngol Head Neck Surg; 2007 Mar;59(1):83-4
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  • [Title] Lipoma of tongue - A rare site for a rare site for a common tumour.
  • Lipoma is the commonest benign tumour occurring at any anatomical site where fat is present.
  • In oral cavity and oropharynx it is a relatively uncommon neoplasm..
  • This is one such rare case of the universal tumour, presenting at the lateral margin of the tongue, for which complete tumour excision was done.

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  • (PMID = 23120399.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3451717
  • [Keywords] NOTNLM ; Lipoma / Tongue
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89. Sugitani I, Toda K, Yamada K, Yamamoto N, Ikenaga M, Fujimoto Y: Three distinctly different kinds of papillary thyroid microcarcinoma should be recognized: our treatment strategies and outcomes. World J Surg; 2010 Jun;34(6):1222-31
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  • BACKGROUND: Papillary microcarcinoma (PMC) of the thyroid generally follows a benign clinical course.
  • Three patients (1%) who developed apparent lymph node metastasis and nine patients (4%) in whom tumor increased in size eventually received surgery after 1-12 years of follow-up.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chi-Square Distribution. Female. Humans. Iodine Radioisotopes / therapeutic use. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Metastasis. Neoplasm Staging. Observation. Prognosis. Proportional Hazards Models. Prospective Studies. Risk Factors. Statistics, Nonparametric. Survival Rate. Thyroidectomy / methods. Ultrasonography

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  • (PMID = 20066418.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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90. O'Callaghan MG, House M, Ebay S, Bhadelia R: Rhabdomyoma of the head and neck demonstrated by prenatal magnetic resonance imaging. J Comput Assist Tomogr; 2005 Jan-Feb;29(1):130-2
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  • [Title] Rhabdomyoma of the head and neck demonstrated by prenatal magnetic resonance imaging.
  • A case of fetal rhabdomyoma (myxoid type) of the head and neck demonstrated on prenatal magnetic resonance imaging (MRI) is presented.
  • This benign tumor of skeletal muscle is uncommon and should not be confused with its malignant counterpart-rhabdomyosarcoma.
  • With the increasing use of ultrafast MRI, the radiologist is more likely to encounter head and neck masses in the fetus.
  • [MeSH-major] Fetal Diseases / diagnosis. Head and Neck Neoplasms / diagnosis. Magnetic Resonance Imaging. Prenatal Diagnosis. Rhabdomyoma / diagnosis
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Gestational Age. Humans. Infant, Newborn. Neoplasm Recurrence, Local / pathology. Pregnancy. Ultrasonography, Prenatal


91. Gaio E, Marioni G, Blandamura S, Staffieri A: Inverted papilloma involving the temporal bone and its association with squamous cell carcinoma: critical analysis of the literature. Expert Rev Anticancer Ther; 2005 Apr;5(2):391-7
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  • Inverted papilloma is a rare, benign neoplasm, which usually originates from the lateral nasal wall and can be locally aggressive, extending into surrounding structures.
  • [MeSH-minor] Combined Modality Therapy. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Prognosis

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  • (PMID = 15877533.001).
  • [ISSN] 1744-8328
  • [Journal-full-title] Expert review of anticancer therapy
  • [ISO-abbreviation] Expert Rev Anticancer Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 35
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92. Saetti R, Derosas F, Silvestrini M, Narne S: Efficacy of autofluoroscence videoendoscopy in the diagnosis of laryngeal lesions. Acta Otorhinolaryngol Ital; 2007 Aug;27(4):181-5
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  • Thirteen patients underwent the procedure for presumed benign lesions; the other 33 cases for pre-operative endoscopic suspicion of pre-cancerous or cancerous lesions.
  • In our experience, autofluorescence evaluation seemed to accurately delineate the limits of the tumour and the possible presence of second primary, proving a useful guide in the choice of sites to make a biopsy.
  • In particular, this endoscopic method has proved to be characterized by higher sensitivity and specificity not inferior to standard endoscopy, both in the discrimination between benign and preneoplastic/neoplastic lesions and between pre-neoplastic and neoplastic.
  • On the contrary, in the study of "frankly benign" laryngeal lesions, this exam does not improve upon the results obtained by standard endoscopy but increases the risk of false positives.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 17957848.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2640022
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93. Pulvermacker B, Seroussi D, Haddad R, Mitrofanoff M: [Pilomatricoma or calcifying epithelioma of Malherbe. A pediatric review of 89 cases]. Ann Chir Plast Esthet; 2007 Feb;52(1):39-42
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  • This tumor, also known as calcifying epithelioma of Malherbe, is common in the pediatric population and occurs mainly on the head and neck region.
  • It is a benign skin neoplasm usually misdiagnosed and yet the most common hair follicle tumor.
  • Principal characteristics and clinical presentation of this tumor are discussed.
  • [MeSH-major] Hair Diseases / pathology. Head and Neck Neoplasms / pathology. Pilomatrixoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 17030388.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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94. Zbären P, Guélat D, Loosli H, Stauffer E: Parotid tumors: fine-needle aspiration and/or frozen section. Otolaryngol Head Neck Surg; 2008 Dec;139(6):811-5
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  • [Title] Parotid tumors: fine-needle aspiration and/or frozen section.
  • OBJECTIVE: The purpose of this study was to analyze and compare the value of fine-needle aspiration cytology (FNAC) and frozen section (FS) analysis in the assessment of parotid gland tumors.
  • SUBJECTS AND METHODS: FNAC and FS analysis of 110 parotid tumors, 68 malignancies and 42 benign tumors, were analyzed and compared with the final histopathologic diagnosis.
  • RESULTS: The accuracy, sensitivity, and specificity of FNAC in detecting malignant tumors were 79 percent, 74 percent, and 88 percent, respectively.
  • On FS analysis, the accuracy, sensitivity, and specificity in detecting malignant tumors were 94 percent, 93 percent, and 95 percent, respectively.
  • The histologic tumor type was correctly diagnosed by FNAC and FS in 27 of 42 (64%) and 39 of 42 (93%) benign tumors, respectively, and in 24 of 68 (35%) and 49 of 68 (72%) malignant neoplasms, respectively.
  • CONCLUSION: The current analysis showed a superiority of FS compared with FNAC regarding the diagnosis of malignancy and tumor typing.
  • [MeSH-minor] Cross-Sectional Studies. Cytodiagnosis. Diagnosis, Differential. Female. Humans. Male. Neoplasm Staging. Predictive Value of Tests. Sensitivity and Specificity

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  • (PMID = 19041508.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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95. Zolota V, Tzelepi V, Charoulis N, Apostolakis E, Dougenis D: Mediastinal rhabdomyoma: case report and review of the literature. Virchows Arch; 2006 Jul;449(1):124-8
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  • Rhabdomyomas are benign tumors in which at least some cells are differentiated as skeletal muscle cells with cytoplasmic cross-striations.
  • Extracardiac adult rhabdomyoma is an extremely uncommon benign neoplasm that usually involves the head and neck region.
  • [MeSH-minor] Actins / analysis. Aged. Biomarkers, Tumor / analysis. Desmin / analysis. Disease-Free Survival. Female. Humans. Immunohistochemistry. Myoglobin / analysis. Radiography, Thoracic. Treatment Outcome

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  • (PMID = 16636850.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Desmin; 0 / Myoglobin
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96. Jundt G, Reichart PA: [Malignant odontogenic tumors]. Pathologe; 2008 May;29(3):205-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Malignant odontogenic tumors].
  • Malignant odontogenic tumors are extremely rare.
  • As with benign odontogenic tumors, malignant epithelial odontogenic tumors or odontogenic carcinomas are distinguished from the even rarer mesenchymal ones, the odontogenic sarcomas.
  • Whereas metastasizing ameloblastoma can be diagnosed only after having metastasized, all other malignant odontogenic tumors present with atypia, increased cellularity and mitoses, and invasion.
  • Odontogenic sarcomas are regarded as low-grade tumors that rarely metastasize.
  • [MeSH-major] Jaw Neoplasms / pathology. Odontogenic Tumors / pathology
  • [MeSH-minor] Ameloblastoma / classification. Ameloblastoma / pathology. Carcinoma / classification. Carcinoma / pathology. Carcinosarcoma / classification. Carcinosarcoma / pathology. Diagnosis, Differential. Humans. Jaw / pathology. Neoplasm Invasiveness. Sarcoma / classification. Sarcoma / pathology

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  • (PMID = 18392827.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
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97. Lee SH, Mah SY, Chung BH: Incidentally discovered inverted papilloma of the urinary bladder in patients with lower urinary tract symptoms. J Endourol; 2010 Feb;24(2):271-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND AND PURPOSE: Inverted urothelial papilloma (IP) is an uncommon urothelial neoplasm.
  • PATIENTS AND METHODS: From 1994 to 2008, 53 patients with urinary IP underwent transurethral resection of the bladder tumor (TURBT) at our institution.
  • In IP located on the bladder neck of patients with benign prostatic hyperplasia (BPH), significantly higher obstructive symptoms and larger prostate volumes than that of other located IP with BPH were observed.
  • Despite the absence of agreement of its etiology, its presenting symptoms were related to LUTS and benign prostatic enlargement.

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  • (PMID = 20039831.001).
  • [ISSN] 1557-900X
  • [Journal-full-title] Journal of endourology
  • [ISO-abbreviation] J. Endourol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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98. Deutsch J, Trick D, Delank KW: [Giant scalp mass]. HNO; 2010 Dec;58(12):1204-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Monströser Tumor der Kopfhaut.
  • A 55-year-old man was referred to our department with bleeding from a painless tumor located at the left parietal region of the head which had been progressively growing for a period of 2 years.
  • The partly livid and ulcerated surface of the tumor was interspersed with light-yellow chalky material.
  • Pilomatricoma is a rare, benign skin neoplasm that originates from hair matrix cells and is most frequently located in the head and neck region.
  • [MeSH-major] Hair Diseases / diagnosis. Head and Neck Neoplasms / diagnosis. Pilomatrixoma / diagnosis. Scalp. Skin Neoplasms / diagnosis

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  • (PMID = 20577705.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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99. Vandecaveye V, De Keyzer F, Hermans R: Diffusion-weighted magnetic resonance imaging in neck lymph adenopathy. Cancer Imaging; 2008;8:173-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diffusion-weighted magnetic resonance imaging in neck lymph adenopathy.
  • In patients with head and neck squamous cell carcinoma (SCC), nodal metastases are an adverse prognostic factor compromising long term patient survival.
  • Computed tomography (CT) and magnetic resonance imaging (MRI) remain the primary imaging modalities for locoregional staging of head and neck SCC.
  • Next to evaluation of the primary tumour, both modalities facilitate detection of non-palpable lymph nodes (LN).
  • However, both modalities rely on size-related and morphological criteria to differentiate between benign and malignant lymph nodes, decreasing the sensitivity for detection of small metastases.
  • The added value of DW-MRI to conventional imaging for staging of lymph nodes in head and neck cancer is discussed, before and after treatment.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / secondary. Diffusion Magnetic Resonance Imaging / methods. Echo-Planar Imaging / methods. Head and Neck Neoplasms / diagnosis. Lymph Nodes / pathology. Lymphatic Diseases / pathology
  • [MeSH-minor] Biopsy, Needle. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Immunohistochemistry. Lymphatic Metastasis. Male. Neck / pathology. Neoplasm Staging. Postoperative Care / methods. Preoperative Care / methods. Radiotherapy, Adjuvant. Sensitivity and Specificity. Surgical Procedures, Operative / methods. Survival Rate. Treatment Outcome

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  • (PMID = 18824423.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 27
  • [Other-IDs] NLM/ PMC2556503
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100. Mortuaire G, Pasquesoone X, Leroy X, Chevalier D: Respiratory epithelial adenomatoid hamartomas of the sinonasal tract. Eur Arch Otorhinolaryngol; 2007 Apr;264(4):451-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Fine histopathological analysis is necessary to avoid aggressive surgery for this benign lesion.
  • [MeSH-major] Adenomatoid Tumor / pathology. Hamartoma / pathology. Paranasal Sinus Neoplasms / pathology. Respiratory Mucosa / pathology
  • [MeSH-minor] Adult. Endoscopy. Female. Humans. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 17089137.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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