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1. Ashraf M, Kumar P, Reza MA, Ragesh KP: Neoplastic diseases of the head & neck in children. Indian J Otolaryngol Head Neck Surg; 2006 Oct;58(4):343-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neoplastic diseases of the head & neck in children.
  • Pediatric neoplasm is next only to trauma as the most common cause of death.
  • The cervicofacial malignancies presents a unique challenge owing to potential adverse effects of both the disease process and the treatment employed on critical developing head and neck structures.This study comprised of 106 children below 12 years age group conducted during 1999-2003 at JNMC, Aligarh.
  • Of 106 cases 70 were benign neoplasms and 36 malignant neoplasms.
  • Nasopharyngeal angiofibroma was the commonest benign tumour and lymphoma was the commonest malignant neoplasm.

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  • (PMID = 23120341.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450388
  • [Keywords] NOTNLM ; Lymphoma / Nasopharyngeal angiofibroma / Neoplasm / Rhabdomyosarcoma
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2. Eversole R, Su L, ElMofty S: Benign fibro-osseous lesions of the craniofacial complex. A review. Head Neck Pathol; 2008 Sep;2(3):177-202
MedlinePlus Health Information. consumer health - Paget's Disease of Bone.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign fibro-osseous lesions of the craniofacial complex. A review.
  • Benign fibro-osseous lesions of the craniofacial complex are represented by a variety of disease processes that are characterized by pathologic ossifications and calcifications in association with a hypercellular fibroblastic marrow element.
  • [MeSH-minor] DNA, Neoplasm / analysis. Humans. Mutation

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  • (PMID = 20614314.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
  • [Other-IDs] NLM/ PMC2807558
  • [Keywords] NOTNLM ; Benign fibroosseous lesions / Cementoma / Cementoosseous dysplasia / Fibrous dysplasia / Ossifying fibroma / Osteitis deformans
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3. Pinchot SN, Al-Wagih H, Schaefer S, Sippel R, Chen H: Accuracy of fine-needle aspiration biopsy for predicting neoplasm or carcinoma in thyroid nodules 4 cm or larger. Arch Surg; 2009 Jul;144(7):649-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Accuracy of fine-needle aspiration biopsy for predicting neoplasm or carcinoma in thyroid nodules 4 cm or larger.
  • The FNAB results were reported as nondiagnostic, benign, inconclusive (follicular neoplasm), or malignant, whereas the final surgical pathologic data were reported as benign or malignant.
  • Preoperative cytologic testing of the mass was performed on 97 patients, and the results read as benign for 52, inconclusive for 23, nondiagnostic for 11, and malignant for 11.
  • In lesions 4 cm or larger, 26 of 52 FNAB results reported as benign (50.0%) turned out to be either neoplastic (22) or malignant (4) on final pathologic analysis.
  • CONCLUSIONS: In patients with thyroid nodules 4 cm or larger, the FNAB results are highly inaccurate, misclassifying half of all patients with reportedly benign lesions.

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  • (PMID = 19620545.001).
  • [ISSN] 1538-3644
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA090217-08; United States / NCI NIH HHS / CA / T32 CA090217-09; United States / NCI NIH HHS / CA / T32 CA090217-10; United States / NCI NIH HHS / CA / T32 CA090217; United States / NCI NIH HHS / CA / CA090217-10; United States / NCI NIH HHS / CA / T32 CA090217-08; United States / NCI NIH HHS / CA / CA090217-09
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS215984; NLM/ PMC2910711
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4. Baghi M, Mack MG, Wagenblast J, Hambek M, Rieger J, Bisdas S, Gstoettner W, Engels K, Vogl T, Knecht R: Iron oxide particle-enhanced magnetic resonance imaging for detection of benign lymph nodes in the head and neck: how reliable are the results? Anticancer Res; 2007 Sep-Oct;27(5B):3571-5
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  • [Title] Iron oxide particle-enhanced magnetic resonance imaging for detection of benign lymph nodes in the head and neck: how reliable are the results?
  • AIM: To evaluate the accuracy of ultrasmall paramagnetic iron oxide (USPIO: Sinerem)-enhanced MRI in patients with head and neck cancer and enlarged lymph nodes compared with current staging examinations using histology as a gold standard.
  • PATIENTS AND METHODS: Seventeen patients with a histologically proven squamous cell cancer of the head and neck (SCCHN) and different N-stages underwent a non-enhanced and a USPIO-enhanced MRI examination.
  • [MeSH-major] Ferric Compounds / metabolism. Head and Neck Neoplasms / diagnosis. Lymph Nodes / pathology. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Middle Aged. Neoplasm Staging

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  • (PMID = 17972519.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Ferric Compounds; 1K09F3G675 / ferric oxide
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5. Kernek KM, Koch MO, Daggy JK, Juliar BE, Cheng L: The presence of benign prostatic glandular tissue at surgical margins does not predict PSA recurrence. J Clin Pathol; 2005 Jul;58(7):725-8
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  • [Title] The presence of benign prostatic glandular tissue at surgical margins does not predict PSA recurrence.
  • BACKGROUND: Serum prostate specific antigen (PSA) increases after radical prostatectomy are thought to indicate recurrent disease, although some suggest they result from benign prostatic epithelial tissue left at surgical margins.
  • AIMS: To investigate whether presence, location, and extent of benign prostatic tissue at radical prostatectomy surgical margins influence patient outcome.
  • The apex and bladder neck, dissected as a cone from the specimen, were serially sectioned.
  • The total length of benign prostatic tissue at the margins, measured for each location using an ocular micrometer, was obtained by summing the length of all positive sites.
  • The presence, anatomical location, and extent of benign prostatic tissue at the margin were correlated with clinicopathological characteristics and postoperative PSA increases.
  • RESULTS: Fifty five cases had benign prostatic glandular tissue at the surgical margin.
  • The most frequent location of benign prostatic tissue was the apex (40 patients).
  • Presence, anatomical location, and length of benign prostatic tissue at the margin were not significantly associated with age, preoperative PSA, prostate weight, pathological stage, tumour volume, largest tumour dimension, Gleason score, extraprostatic extension, seminal vesical invasion, tumour multifocality, perineural invasion, or PSA recurrence.
  • CONCLUSIONS: Benign prostatic tissue was frequently found in margins of apex and bladder base, but uncommon in the anterior or posterior prostate.
  • The presence of benign prostatic tissue at surgical margins had no prognostic relevance.
  • [MeSH-minor] Adult. Age Factors. Aged. Humans. Male. Middle Aged. Neoplasm Staging. Postoperative Period. Prognosis. Prostatectomy. Recurrence


6. Nørby B, Nielsen KK: [Surgical treatment of benign prostatic hyperplasia in Denmark--1993-2003]. Ugeskr Laeger; 2007 May 14;169(20):1898-901
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  • [Title] [Surgical treatment of benign prostatic hyperplasia in Denmark--1993-2003].
  • [Transliterated title] Kirurgisk behandling af benign prostatahyperplasi i Danmark 1993-2003.
  • BPH-related cases include prostatic hypertrophia, benign prostatic neoplasm, bladder stone, urinary retention, hematuria, LUTS, and bladder neck stenosis.

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  • (PMID = 17553366.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Editorial; English Abstract
  • [Publication-country] Denmark
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7. Banhiran W, Casiano RR: Endoscopic sinus surgery for benign and malignant nasal and sinus neoplasm. Curr Opin Otolaryngol Head Neck Surg; 2005 Feb;13(1):50-4
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  • [Title] Endoscopic sinus surgery for benign and malignant nasal and sinus neoplasm.
  • In the recent literature, emphasis has been on the endoscopic surgery of benign tumors, especially inverted papilloma and nasopharyngeal angiofibroma.
  • Other benign neoplasms have also been reported, but only in small case reports.
  • Especially for the more common benign neoplasms, such as inverted papilloma and early stage angiofibroma.
  • Large tumor size, intracranial or orbital extension, and extensive frontal or infratemporal fossa involvement are relative, but not absolute limitations.

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  • (PMID = 15654216.001).
  • [ISSN] 1068-9508
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 43
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8. Domfeh AB, Fichera M, Hunt JL: Allelic loss of 3 different tumor suppressor gene loci in benign and malignant endothelial tumors of the head and neck. Arch Pathol Lab Med; 2006 Aug;130(8):1184-7
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  • [Title] Allelic loss of 3 different tumor suppressor gene loci in benign and malignant endothelial tumors of the head and neck.
  • CONTEXT: Angiosarcomas are rare malignancies that commonly arise in the head and neck.
  • OBJECTIVE: This study compared the molecular profile of angiosarcoma with that in some benign vascular lesions.
  • This supports the cell culture-based theories that tumorigenesis in endothelial cells likely involves these chromosomes and provides some insight into the potential pathogenesis of angiosarcomas and benign hemangiomas.
  • [MeSH-major] Genes, Tumor Suppressor. Head and Neck Neoplasms / genetics. Hemangioma / genetics. Hemangiosarcoma / genetics. Loss of Heterozygosity / genetics
  • [MeSH-minor] Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 13. Chromosomes, Human, Pair 17. DNA, Neoplasm / analysis. Endothelium, Vascular / pathology. Genes, Retinoblastoma. Genes, Wilms Tumor. Genes, p53. Genetic Markers. Granulation Tissue / pathology. Humans. Microdissection. Microsatellite Repeats / genetics

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  • (PMID = 16879020.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Genetic Markers
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9. Lombardi D, Piccioni M, Farina D, Morassi ML, Nicolai P: Oncocytic carcinoma of the maxillary sinus: a rare neoplasm. Eur Arch Otorhinolaryngol; 2006 Jun;263(6):528-31

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oncocytic carcinoma of the maxillary sinus: a rare neoplasm.
  • Oncocytic neoplasms are tumors composed of oncocytes (i.e., epithelial cells with a large cytoplasm that is rich in mitochondria).
  • Most cases are benign and originate from the major salivary glands, while the minor salivary glands are rarely involved.
  • Biopsy was consistent with an unspecified salivary gland neoplasm.
  • A brief analysis of the literature was also accomplished in order to discuss treatment options and prognosis of this unusual neoplasm.

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  • (PMID = 16474973.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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10. Mentzel T, Kutzner H: Dermatomyofibroma: clinicopathologic and immunohistochemical analysis of 56 cases and reappraisal of a rare and distinct cutaneous neoplasm. Am J Dermatopathol; 2009 Feb;31(1):44-9
MedlinePlus Health Information. consumer health - Skin Cancer.

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  • [Title] Dermatomyofibroma: clinicopathologic and immunohistochemical analysis of 56 cases and reappraisal of a rare and distinct cutaneous neoplasm.
  • Dermatomyofibroma represents a rare and distinct benign cutaneous mesenchymal neoplasm of fibroblastic/myofibroblastic differentiation.
  • The shoulder (13 cases) was the anatomic site most commonly affected, followed by the upper arm (7 cases), the neck (6 cases), the thigh (6 cases), the chest wall (4 cases), the back (3 cases), the axillary fold (2 cases), the abdominal wall (2 cases), and 1 case each was seen on the forearm, the buttock, and the popliteal fossa (exact anatomic location was unknown in 10 cases).
  • Histologically, an ill-defined, plaque-like dermal neoplasm of varying cellularity was seen in all cases, composed of bland spindle-shaped tumor cells often oriented parallel to the overlying epidermis.
  • Immunohistochemically, tumor cells in 11 of 48 cases tested stained positively for alpha-smooth muscle actin, and a focal expression of this marker was noted in 20 cases.
  • Dermatomyofibroma represents a benign fibroblastic/myofibroblastic dermal neoplasm.
  • [MeSH-major] Histiocytoma, Benign Fibrous / metabolism. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / metabolism. Skin Neoplasms / pathology

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  • (PMID = 19155724.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Avninder S, Ramesh V, Vermani S: Benign nerve sheath myxoma (myxoid neurothekeoma) in the leg. Dermatol Online J; 2007;13(2):14
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  • [Title] Benign nerve sheath myxoma (myxoid neurothekeoma) in the leg.
  • Myxoid neurothekeoma is a rare benign cutaneous neoplasm of nerve sheath origin and is also called as benign nerve sheath myxoma.
  • This entity is seen in head, neck and upper extremity and seldom on the lower limb.

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  • (PMID = 17498433.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Ahmed M, Bin Yousef H, Greer W, Faraz H, Al Sobhi S, Al Zahrani A, Raef H, Al Ghamdi A, Al Kadhi Y, Al Dayel F: Hurthle cell neoplasm of the thyroid gland. ANZ J Surg; 2008 Mar;78(3):139-43
MedlinePlus Health Information. consumer health - Thyroid Cancer.

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  • [Title] Hurthle cell neoplasm of the thyroid gland.
  • BACKGROUND: A clinicopathological analysis and long-term follow up of 32 patients with Hurthle cell neoplasm (HCN) was undertaken to contrast the clinical and histological features between benign versus malignant HCN of thyroid and to examine the effect of treatment on the outcome.
  • RESULTS: Seventeen patients were classified as malignant HCN (MHCN) and 15 as benign HCN (BHCN).
  • The mean tumour size was 4.43 +/- 0.66 cm for MHCN, and 2.57 +/- 0.32 cm for BHCN (P = 0.03).
  • Multicentric tumour foci were evident in five cases (29%) of MHCN but none among the BHCN (P = 0.03).
  • At neck exploration cervical lymph node dissection was carried out in nine MHCN patients with findings of tumour metastases in 33%.
  • Postoperatively, three MHCN patients had no thyroid remnant on ultrasound and computed tomography of neck and undetectable serum thyroglobulin; these were considered to be in remission.
  • CONCLUSION: Features of MHCN consisted of a large tumour size, unequivocal capsular and vascular invasion, multicentric tumour foci, metastatic lymph node deposits in one-third of patients and presence of distant metastasis in a few.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / surgery. Neoplasm Recurrence, Local / pathology. Thyroid Neoplasms / pathology. Thyroid Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Registries. Retrospective Studies. Risk Assessment. Survival Analysis. Thyroidectomy / methods. Treatment Outcome

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  • [CommentIn] ANZ J Surg. 2008 Mar;78(3):115 [18269467.001]
  • (PMID = 18269475.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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13. Holzmann D, Hegyi I, Rajan GP, Harder-Ruckstuhl M: Management of benign inverted sinonasal papilloma avoiding external approaches. J Laryngol Otol; 2007 Jun;121(6):548-54
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  • [Title] Management of benign inverted sinonasal papilloma avoiding external approaches.
  • Our results encourage us to recommend endoscopic management as the standard treatment of benign inverted papillomas.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Endoscopy / methods. Humans. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Prospective Studies

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  • (PMID = 17076932.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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14. Sakurai H, Kaji M, Mukai K, Suemasu K: Ectopic hamartomatous thymoma--a truly rare neoplasm: report of a case. Surg Today; 2010;40(2):146-9
MedlinePlus Health Information. consumer health - Thymus Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ectopic hamartomatous thymoma--a truly rare neoplasm: report of a case.
  • An ectopic hamartomatous thymoma is an extremely rare benign neoplasm that commonly occurs in the lower neck region.

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  • (PMID = 20107954.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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15. Gulcelik NE, Gulcelik MA, Kuru B: Risk of malignancy in patients with follicular neoplasm: predictive value of clinical and ultrasonographic features. Arch Otolaryngol Head Neck Surg; 2008 Dec;134(12):1312-5
MedlinePlus Health Information. consumer health - Thyroid Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Risk of malignancy in patients with follicular neoplasm: predictive value of clinical and ultrasonographic features.
  • OBJECTIVE: To identify clinical and ultrasonographic features that may help in predicting malignant tumors in patients with a diagnosis of follicular neoplasm on findings from fine-needle aspiration cytology (FNAC) because FNAC diagnosis of follicular neoplasm does not differentiate a benign tumor from a malignant tumor.
  • DESIGN: Prospective study of 98 patients having a diagnosis of follicular neoplasm on FNAC.
  • PATIENTS: Ninety-eight patients with thyroid nodules diagnosed by FNAC as being a follicular neoplasm.
  • Older age, male sex, solitary nodule, and larger nodule size were not predictive for malignant neoplasms in patients with follicular neoplasm cytologic findings.

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  • (PMID = 19075128.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Shimanovich I, Krahl D, Rose C: Trichoadenoma of Nikolowski is a distinct neoplasm within the spectrum of follicular tumors. J Am Acad Dermatol; 2010 Feb;62(2):277-83
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Trichoadenoma of Nikolowski is a distinct neoplasm within the spectrum of follicular tumors.
  • BACKGROUND: Trichoadenoma is a rare benign follicular tumor first described by Nikolowski 50 years ago.
  • In trichoadenoma the cystic component predominates, while desmoplastic trichoepithelioma is a mostly solid neoplasm.
  • LIMITATIONS: This study is limited by the moderate number of these rare tumors available for immunohistochemical analysis.
  • Trichoadenoma is a distinct follicular tumor related but not identical to desmoplastic trichoepithelioma.
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Female. Head and Neck Neoplasms / pathology. Humans. Immunohistochemistry. Keratin-20 / metabolism. Male. Merkel Cells / pathology. Middle Aged. Neoplasms, Fibroepithelial / pathology. Receptors, Androgen / metabolism. Skin / chemistry

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  • [Copyright] Copyright (c) 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20115950.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AR protein, human; 0 / Biomarkers, Tumor; 0 / Keratin-20; 0 / Receptors, Androgen; 0 / human epithelial antigen-125
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17. Roarke MC, Nguyen BD: Fat hypertrophy in a pharyngeal reconstruction flap presenting as an enlarging neck mass: demonstration of benign changes with PET/CT. Clin Nucl Med; 2006 Jan;31(1):48-9
MedlinePlus Health Information. consumer health - Throat Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fat hypertrophy in a pharyngeal reconstruction flap presenting as an enlarging neck mass: demonstration of benign changes with PET/CT.
  • The patient is a 73-year-old man with a history of radioresistant recurrent squamous cell carcinoma of the larynx, treated with total laryngectomy/pharyngectomy and rectus abdominis deep inferior epigastric perforator flap reconstruction, who presented with a painless enlarging neck mass.
  • Physical examination revealed increased neck bulk and fiberoptic nasopharyngolaryngoscopy was negative.
  • The clinician was concerned about underlying recurrent neoplasm or adenopathy displacing the flap outward and referred the patient for PET/CT.

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  • (PMID = 16374129.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Zhang H, Feng Y, Jiang L: [Tumorectomy by trans-oral approach of macrosis benign neoplasms in parapharyngeal space (reports of 6 cases)]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2010 Jun;24(12):556-8
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  • [Title] [Tumorectomy by trans-oral approach of macrosis benign neoplasms in parapharyngeal space (reports of 6 cases)].
  • OBJECTIVE: To discuss the feasibility of tumorectomy by transoral approach of macrosis benign neoplasms in parapharyngeal space.
  • METHOD: Retrospective analyze 6 patients of macrosis benign neoplasms in parapharyngeal space from January 2005 to May 2008, and all neoplasms were removed by transoral approach.
  • CONCLUSION: Preoperative imaging examination is very important for diagnosis and treatment of benign neoplasm in parapharyngeal space, which is especially helpful to understand the scope of the tumor, and the relationship with carotid artery and vein.
  • On this basis, it is feasible to select the appropriate cases to resect huge benign neoplasm in parapharyngeal space.

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  • (PMID = 20806862.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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19. Henrique R, Jerónimo C, Hoque MO, Carvalho AL, Oliveira J, Teixeira MR, Lopes C, Sidransky D: Frequent 14-3-3 sigma promoter methylation in benign and malignant prostate lesions. DNA Cell Biol; 2005 Apr;24(4):264-9
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  • [Title] Frequent 14-3-3 sigma promoter methylation in benign and malignant prostate lesions.
  • 14-3-3Sigma is a putative tumor suppressor gene involved in cell cycle regulation and apoptosis following DNA damage.
  • Here, we investigate the frequency and extent of 14-3-3sigma promoter methylation in benign and cancerous prostate tissues.
  • We examined tumor tissue from 121 patients with prostate carcinoma (PCa), 39 paired high-grade prostatic intraepithelial neoplasias (HGPIN), 29 patients with benign prostate hyperplasia (BPH), as well as four prostate cancer cell lines using quantitative methylation-specific PCR (QMSP).
  • [MeSH-major] Adenocarcinoma / genetics. Biomarkers, Tumor / metabolism. DNA Methylation. Exonucleases / metabolism. Gene Silencing. Neoplasm Proteins / metabolism. Prostatic Hyperplasia / genetics. Prostatic Intraepithelial Neoplasia / genetics. Prostatic Neoplasms / genetics
  • [MeSH-minor] 14-3-3 Proteins. Analysis of Variance. Cell Line, Tumor. Exoribonucleases. Histological Techniques. Humans. Male. Polymerase Chain Reaction / methods. Portugal. Promoter Regions, Genetic / genetics. Prostate / pathology. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 15812243.001).
  • [ISSN] 1044-5498
  • [Journal-full-title] DNA and cell biology
  • [ISO-abbreviation] DNA Cell Biol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 14-3-3 Proteins; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; EC 3.1.- / Exonucleases; EC 3.1.- / Exoribonucleases; EC 3.1.- / SFN protein, human
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20. Mendes RA, Carvalho JF, Waal Iv: An overview on the expression of cyclooxygenase-2 in tumors of the head and neck. Oral Oncol; 2009 Oct;45(10):e124-8
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  • [Title] An overview on the expression of cyclooxygenase-2 in tumors of the head and neck.
  • Cyclooxygenase-2 (COX-2) levels are increased in various tumors, particularly those involving the esophagus, stomach, breast, pancreas, lung, colon, skin, urinary bladder, prostate and head and neck.
  • Thus, the literature shows increasing evidence that overexpression of the COX-2 plays an important role in tumor growth and spread of tumors by interfering with different biological processes such as cell proliferation, cellular adhesion, immune surveillance, apoptosis, and angiogenesis.
  • Furthermore, the expression of COX-2 might shed some light over the physiopathology and clinical behavior of tumors of the head and neck, including benign odontogenic neoplasms of the jaws with an aggressive behavior, such as keratocystic odontogenic tumors (KCOT).
  • Ultimately, the research of molecular markers associated with the biological behavior of tumors will help to understand the underlying molecular mechanisms and to predict the clinical outcome, leading to the development of new therapeutic applications, such as molecular-targeted treatment and patient tailored therapy.
  • [MeSH-major] Cyclooxygenase 2 / metabolism. Head and Neck Neoplasms / metabolism. Neoplasm Proteins / metabolism

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  • (PMID = 19457709.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Prostaglandins; EC 1.14.99.1 / Cyclooxygenase 2
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21. Laskin WB, Fetsch JF, Lasota J, Miettinen M: Benign epithelioid peripheral nerve sheath tumors of the soft tissues: clinicopathologic spectrum of 33 cases. Am J Surg Pathol; 2005 Jan;29(1):39-51
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  • [Title] Benign epithelioid peripheral nerve sheath tumors of the soft tissues: clinicopathologic spectrum of 33 cases.
  • Benign epithelioid peripheral nerve sheath tumors (BEPNSTs) have not been fully characterized, and their relationship to conventional schwannoma and neurofibroma has not been satisfactorily established.
  • The tumors were predominantly dermal/subcutaneous in location (85%) and involved the lower limb (n=15), upper limb (n=11), trunk (n=4), and head/neck (n=3).
  • Microscopically, the tumors were generally well-circumscribed, uninodular, or multinodular masses.
  • Tumors consisted of trabeculae, loosely arranged nodules, and cohesive nests of epithelioid tumor cells immersed in collagenous, myxohyaline, or chiefly myxoid stroma.
  • A bland spindled cell component comprising 5% to 40% of the tumor was noted in 15 cases.
  • Immunohistochemical reactivity for Schwann cell-related markers in tumor cells included S-100 protein (20 of 20 cases), collagen type IV (10 of 10), laminin (8 of 8), nerve growth factor receptor, p75(7 of 8), CD57 (6 of 9), and glial fibrillary acidic protein (8 of 15).
  • Anti-epithelial membrane antigen highlighted perineurial cells in 9 of the 11 encapsulated tumors.
  • Anti-neurofilament protein did not identify intralesional neuraxons in the 10 tumors evaluated.
  • Eighteen tumors were subtyped as epithelioid neurofibromas.
  • Follow-up for 18 patients (median interval, 13.5 years), including 4 patients with tumors exhibiting cytologic atypia, revealed a nondestructive recurrence or persistent disease in 3 patients whose tumors lacked atypia, but no evidence of metastatic spread or tumor-related death.
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Child. Child, Preschool. DNA, Neoplasm / analysis. Female. Humans. Immunoenzyme Techniques. Loss of Heterozygosity. Male. Middle Aged. Mitotic Index. Neurofibromin 1 / genetics. Neurofibromin 1 / metabolism. Neurofibromin 2 / genetics. Neurofibromin 2 / metabolism. Polymerase Chain Reaction

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  • (PMID = 15613855.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Neurofibromin 1; 0 / Neurofibromin 2
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22. Zhou YA, Huang JH, Wan CY, Zuo ZB: [Surgical treatment and effect observation of cervical intraspinal benign neoplasms]. Zhongguo Gu Shang; 2009 Nov;22(11):856-8
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  • [Title] [Surgical treatment and effect observation of cervical intraspinal benign neoplasms].
  • OBJECTIVE: To investigate the diagnosis, surgical procedure and clinical outcome of cervical intraspinal benign neoplasm.
  • Symptoms mainly included neck pain, numbness and weakness of the extremities, urinary and fecal incontinence, pyramid signs, etc.
  • The tumors were removed completely in 18 cases, above 60% in 3 cases and 25% with biopsy in 1 case.
  • Cervical stability in 11 cases was restored after removal of tumors.
  • CONCLUSION: The surgical exairesis for cervical intraspinal benign neoplasm has low post-operative recurrence.
  • The main reason of recurrence is not removed the tumor completely.

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  • (PMID = 20084949.001).
  • [ISSN] 1003-0034
  • [Journal-full-title] Zhongguo gu shang = China journal of orthopaedics and traumatology
  • [ISO-abbreviation] Zhongguo Gu Shang
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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23. Sanabria A, Carvalho AL, Piana de Andrade V, Pablo Rodrigo J, Vartanian JG, Rinaldo A, Ikeda MK, Devaney KO, Magrin J, Augusto Soares F, Ferlito A, Kowalski LP: Is galectin-3 a good method for the detection of malignancy in patients with thyroid nodules and a cytologic diagnosis of "follicular neoplasm"? A critical appraisal of the evidence. Head Neck; 2007 Nov;29(11):1046-54
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  • [Title] Is galectin-3 a good method for the detection of malignancy in patients with thyroid nodules and a cytologic diagnosis of "follicular neoplasm"? A critical appraisal of the evidence.
  • Immunostaining of cytological smears from FNAB with galectin-3 has been proposed as a tool for differentiating between benign and malignant nodules.
  • METHODS: Prospective studies of nodules with FNAB reports of "follicular neoplasm" and with a definitive diagnosis confirmed by histopathology were selected.
  • CONCLUSION: Galectin-3 could be a good tool to guide therapeutic decision in patients with thyroid nodules and FNAB results of follicular neoplasm, but available information has methodological flaws that precludes a definitive answer about galectin-3 utility in the clinical setting.

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  • (PMID = 17525969.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Galectin 3
  • [Number-of-references] 68
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24. Juhlin J, Eiholm S: [Rhabdomyoma in the head and neck region]. Ugeskr Laeger; 2009 Mar 30;171(14):1194
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  • [Title] [Rhabdomyoma in the head and neck region].
  • Extracardiac rhabdomyoma is an extremely uncommon benign neoplasm with skeletal muscle differentiation which usually involves the head and neck region.
  • In both cases, an asymptomatic neck mass was noticed by the patient.
  • Adult rhabdomyomas should be considered as a differential diagnosis in the head and neck region.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Rhabdomyoma / diagnosis

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  • (PMID = 19338741.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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25. Lian X, Zhao J, Hou T, Ma H, Chen Z: Benign intraspinal osteoblastoma stemming from C7 lamina in cervicothoracic junction: a case report. Spine (Phila Pa 1976); 2006 Nov 1;31(23):E895-9
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  • [Title] Benign intraspinal osteoblastoma stemming from C7 lamina in cervicothoracic junction: a case report.
  • STUDY DESIGN: A case report of a rare benign osteoblastoma successfully treated with total en bloc excision.
  • SUMMARY OF BACKGROUND DATA: A rare case of massive benign osteoblastoma stemming from left side lamina of C7 and extension to spinal canal from C6 to T1 resulting in spinal cord compressed severely is reported.
  • METHODS: A 13-year-old girl complained of gradually increasing pain of her lower part of the neck and left shoulder radiating to the left upper extremity, and the neurologic deficits were found in physical examination.
  • A massive neoplasm located in intraspinal cervicothoracic junction and the spinal cord compressed severely was shown in radiographs, MRI, and CT.
  • The neoplasm was removed totally with instrumentation performed in surgical intervention.
  • Recurrence of the tumor was not seen at the final follow-up.

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  • (PMID = 17077728.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Wang CP, Chang YL, Ko JY, Cheng CH, Yeh CF, Lou PJ: Desmoid tumor of the head and neck. Head Neck; 2006 Nov;28(11):1008-13
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  • [Title] Desmoid tumor of the head and neck.
  • BACKGROUND: [corrected] Desmoid tumors are rare benign tumors but have a tendency toward local recurrence after resection because of their infiltrative growth and frequent entrapment of vital structures in the head and neck region.
  • We report 24 desmoid tumors of the head and neck and propose a reasonable approach in the management of such cases.
  • METHODS: Twenty-four patients (9 male and 15 female; median age, 33 years; range, 0-66 years) with a desmoid tumor of the head and neck (neck, 15 patients; head, 9 patients) treated from 1990 to 2004 were retrospectively analyzed.
  • In the neck, 8 tumors were around the superficial layer of deep cervical fascia, whereas 4 tumors of the neck involved the prevertebral fascia and 2 involved brachial plexus.
  • RESULTS: Twenty patients received complete resection of the tumor, but the section margin was positive in 8 patients, of which 6 patients remained free of disease in a period of 13 to 105 months.
  • Two patients underwent partial resection of the tumor because of brachial plexus involvement.
  • The hypopharygneal tumor in a newborn had spontaneously complete regression, and tracheostomy was closed at the age of 6 years.
  • One patient remained with stable disease for 14 months after biopsy of the tumor without excision.
  • Surgical resection of the tumor with close observation is suggested even if the section margin is positive.
  • If a desmoid tumor cannot be removed grossly, regression or arrested growth of the remaining tumor is expected.
  • Radiotherapy might be reserved for a growing tumor.
  • [MeSH-major] Fibromatosis, Aggressive / surgery. Head and Neck Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Infant. Infant, Newborn. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Radiotherapy, Adjuvant. Retrospective Studies

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  • (PMID = 16983695.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Chen X, Yu K, Tong GX, Hood M, Storper I, Hamele-Bena D: Fine needle aspiration of pleomorphic lipoma of the neck: report of two cases. Diagn Cytopathol; 2010 Mar;38(3):184-7
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  • [Title] Fine needle aspiration of pleomorphic lipoma of the neck: report of two cases.
  • Pleomorphic lipoma is a rare lipocytic neoplasm that most commonly occurs in the head and neck region in middle-aged to elderly men.
  • Histopathologically and cytogenetically, it has some features overlapping with other benign and malignant tumors, such as benign spindle cell lipoma, atypical lipomatous tumor, liposarcoma, and malignant fibrous histiocytoma.
  • Due to the rarity of this tumor, few cases diagnosed by cytology have been reported in the English literature.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Lipoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Chromosome Aberrations. Chromosomes, Human, 16-18. Chromosomes, Human, Pair 13. Diagnosis, Differential. Fat Necrosis / diagnosis. Humans. Incidental Findings. Magnetic Resonance Imaging. Male. Middle Aged. Spinal Neoplasms / pathology. Treatment Outcome

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  • (PMID = 19774616.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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28. Valdez TA, Desai U, Volk MS: Recurrent fetal rhabdomyoma of the head and neck. Int J Pediatr Otorhinolaryngol; 2006 Jun;70(6):1115-8
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  • [Title] Recurrent fetal rhabdomyoma of the head and neck.
  • A congenital fetal rhabdomyoma involving the head and neck region diagnosed prenatally by ultrasound and MRI was surgically excised without complications.
  • The patient presented with recurrence of the tumor fourteen months after the initial surgery.
  • Extracardiac rhabdomyomas are extremely rare benign tumors.
  • [MeSH-major] Head and Neck Neoplasms / congenital. Neoplasm Recurrence, Local / pathology. Rhabdomyoma / congenital

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  • (PMID = 16406074.001).
  • [ISSN] 0165-5876
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Ireland
  • [Number-of-references] 11
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29. Pietarinen-Runtti P, Apajalahti S, Robinson S, Passador-Santos F, Leivo I, Mäkitie AA: Cystic neck lesions: clinical, radiological and differential diagnostic considerations. Acta Otolaryngol; 2010 Feb;130(2):300-4
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  • [Title] Cystic neck lesions: clinical, radiological and differential diagnostic considerations.
  • CONCLUSIONS: Metastatic disease should always be considered as a potential differential diagnosis in the adult patient with a cystic neck lesion.
  • OBJECTIVES: The most common cause of a cystic neck lesion in young adults is a branchial cleft cyst (BCC).
  • This study aimed to investigate the incidence of unsuspected carcinoma in routinely excised cervical cysts at a tertiary care teaching hospital and to determine the characteristics of benign BCC and cystic malignancy in preoperative imaging.
  • PATIENTS AND METHODS: A total of 196 consecutive adult patients operated on with the initial diagnosis of benign lateral cervical cyst were identified and the hospital charts and imaging studies were reviewed.
  • Therefore, the incidence of unsuspected carcinoma in the cystic neck lesions initially diagnosed as BCC was 3.6%.
  • [MeSH-minor] Adolescent. Adult. Aged. Diagnosis, Differential. Female. Humans. Incidence. Male. Middle Aged. Neck. Neoplasm Staging. Prevalence. Survival Rate. Young Adult

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  • (PMID = 19593684.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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30. Fei Z, Zhang X, Jiang XF, Liu WP, Wang XL, Xie L: Removal of large benign cephalonasal tumours by transbasal surgery combined with endonasal endoscopic sinus surgery and neuronavigation. J Craniomaxillofac Surg; 2007 Jan;35(1):30-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Removal of large benign cephalonasal tumours by transbasal surgery combined with endonasal endoscopic sinus surgery and neuronavigation.
  • In 20 cases neuronavigation was used in addition to locate the tumour and adjoining structures.
  • RESULTS: Twenty-seven cases had a complete removal of the tumour whilst the others had only a subtotal resection.
  • CONCLUSION: Transbasal surgery combined with endonasal endoscopic sinus surgery and neuronavigation is a particularly useful technique for resecting large benign cephalonasal tumours.
  • [MeSH-major] Endoscopy / methods. Head and Neck Neoplasms / surgery. Neuronavigation / methods. Skull Base / surgery
  • [MeSH-minor] Abducens Nerve Diseases / etiology. Adolescent. Adult. Child. Child, Preschool. Deglutition Disorders / etiology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Nasal Cavity / surgery. Neoplasm Recurrence, Local / surgery. Neoplasm, Residual / pathology. Nose Neoplasms / surgery. Olfaction Disorders / etiology. Ophthalmoplegia / etiology. Paralysis / etiology. Paranasal Sinus Neoplasms / surgery. Radiotherapy, Adjuvant. Reoperation. Retrospective Studies. Skull Base Neoplasms / surgery

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  • (PMID = 17261369.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
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31. Duet M, Guichard JP, Rizzo N, Boudiaf M, Herman P, Tran Ba Huy P: Are somatostatin analogs therapeutic alternatives in the management of head and neck paragangliomas? Laryngoscope; 2005 Aug;115(8):1381-4
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  • [Title] Are somatostatin analogs therapeutic alternatives in the management of head and neck paragangliomas?
  • BACKGROUND: Although mostly benign, head and neck paragangliomas require active management because of injury to adjacent neurovascular structures.
  • Surgery, usually preceded by embolization, allows for complete tumor removal.
  • However, surgery carries a significant risk of iatrogenic injury, related to tumor volume.
  • Because paragangliomas express somatostatin receptors with high density, we investigated the effect of a long-acting somatostatin analogue (OCT-LAR) on the size of such tumors to reduce iatrogenic injury and related the percentage of tumor shrinkage to a tracer uptake index calculated on somatostatin receptor scintigraphy (SRS).
  • All 18 tumors were measured by CT scan before treatment and 1 month after the third injection.
  • RESULTS: The average percent tumor shrinkage was 4.0 +/- 10.0%, and the average tumor reduction was 1.0 +/- 3.8 cm (P = .27, NS).
  • Only 2 of the 18 paragangliomas shrank by more than 20%; these two tumors belonged to the only one secreting patient.
  • There was no significant relation between tracer uptake index and tumor response.
  • [MeSH-major] Head and Neck Neoplasms / drug therapy. Octreotide / administration & dosage. Paraganglioma / drug therapy. Somatostatin / analogs & derivatives
  • [MeSH-minor] Adult. Dose-Response Relationship, Drug. Drug Administration Schedule. Female. Follow-Up Studies. Humans. Injections, Intramuscular. Male. Middle Aged. Neoplasm Staging. Predictive Value of Tests. Preoperative Care / methods. Prospective Studies. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome. Tumor Burden

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  • (PMID = 16094109.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 51110-01-1 / Somatostatin; RWM8CCW8GP / Octreotide
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32. Ungari C, Paparo F, Colangeli W, Iannetti G: Parotid glands tumours: overview of a 10-year experience with 282 patients, focusing on 231 benign epithelial neoplasms. Eur Rev Med Pharmacol Sci; 2008 Sep-Oct;12(5):321-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parotid glands tumours: overview of a 10-year experience with 282 patients, focusing on 231 benign epithelial neoplasms.
  • Salivary gland tumours are uncommon, representing less than 6% of head and neck neoplasm.
  • Pleomorphic adenoma is the most common benign epithelial salivary gland neoplasm, comprising 50%-74% of all parotid tumours.
  • It is followed by Warthin's tumour (4-14%).
  • The authors retrospectively reviewed 282 eligible patients surgically treated for parotid gland tumours in the last 10 years, focusing on 231 benign epithelial neoplasms.
  • The diagnosis of a parotid gland neoplasm must be considered in any patient presenting with a lump near the mandible.
  • Smoking habit is important in Warthin's tumour pathogenesis.
  • Tumour pseudopodia and capsule ruptures are recognised factors involved in pleomorphic adenoma recurrences but also tumour multicentricity might play an important role.

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  • (PMID = 19024217.001).
  • [ISSN] 1128-3602
  • [Journal-full-title] European review for medical and pharmacological sciences
  • [ISO-abbreviation] Eur Rev Med Pharmacol Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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33. O'Callaghan MG, House M, Ebay S, Bhadelia R: Rhabdomyoma of the head and neck demonstrated by prenatal magnetic resonance imaging. J Comput Assist Tomogr; 2005 Jan-Feb;29(1):130-2
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  • [Title] Rhabdomyoma of the head and neck demonstrated by prenatal magnetic resonance imaging.
  • A case of fetal rhabdomyoma (myxoid type) of the head and neck demonstrated on prenatal magnetic resonance imaging (MRI) is presented.
  • This benign tumor of skeletal muscle is uncommon and should not be confused with its malignant counterpart-rhabdomyosarcoma.
  • With the increasing use of ultrafast MRI, the radiologist is more likely to encounter head and neck masses in the fetus.
  • [MeSH-major] Fetal Diseases / diagnosis. Head and Neck Neoplasms / diagnosis. Magnetic Resonance Imaging. Prenatal Diagnosis. Rhabdomyoma / diagnosis
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Gestational Age. Humans. Infant, Newborn. Neoplasm Recurrence, Local / pathology. Pregnancy. Ultrasonography, Prenatal


34. Bolzoni A, Pianta L, Farina D, Nicolai P: Benign myoepithelioma of the lacrimal gland: report of a case. Eur Arch Otorhinolaryngol; 2005 Mar;262(3):186-8
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  • [Title] Benign myoepithelioma of the lacrimal gland: report of a case.
  • A mass in the right lacrimal fossa was detected at MRI and turned out to be benign myoepithelioma of the lacrimal gland at the histopathological examination.
  • [MeSH-minor] Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Surgical Procedures, Operative / methods

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  • [Cites] Br J Ophthalmol. 1992 Oct;76(10):634-6 [1329939.001]
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  • (PMID = 15138773.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 9
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35. Moore T, McLain RF: Image-guided surgery in resection of benign cervicothoracic spinal tumors: a report of two cases. Spine J; 2005 Jan-Feb;5(1):109-14

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Image-guided surgery in resection of benign cervicothoracic spinal tumors: a report of two cases.
  • BACKGROUND CONTEXT: Osseous spinal tumors are an uncommon cause of persistent axial pain and muscle spasm, but even benign lesions may grow to cause deformity or neurological signs.
  • Traditional treatment approaches to resection can be debilitating even when the tumor is benign.
  • PURPOSE: Emerging technologies allow surgeons to diagnose and treat osseous neoplasms while minimizing the collateral damage caused by surgical exposure and tumor excision.
  • STUDY DESIGN: Technical considerations are presented through two cases of benign osseous neoplasm occurring in the cervicothoracic spine of competitive athletes, demonstrating the meth-ods used to provide effective treatment while maintaining maximal functional capacity.
  • METHODS: Stereotactic imaging and intraoperative guidance was used as an adjunct to tumor care in these patients.
  • Used in combination with minimally invasive, microsurgical techniques,stereotactic guidance localized and verified excision margins of benign vertebral lesions, minimizing soft tissue trauma and collateral damage.
  • RESULTS: Computer-assisted stereotactic localization allowed us to successfully ablate these lesions from their anatomically challenging locations, without disrupting the shoulder girdle or neck musculature, and without extensive bony resection.
  • CONCLUSIONS: Image guidance can accurately localize and guide excision of benign vertebral lesions while minimizing soft tissue trauma and collateral damage, allowing patients a rapid and complete return to high-demand function.

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  • (PMID = 15739278.001).
  • [ISSN] 1529-9430
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. Krestan C, Herneth AM, Formanek M, Czerny C: Modern imaging lymph node staging of the head and neck region. Eur J Radiol; 2006 Jun;58(3):360-6
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  • [Title] Modern imaging lymph node staging of the head and neck region.
  • The aim of this paper is to describe the modern imaging methods, their techniques, ability, and performance in staging head and neck lymph nodes.
  • Also, the imaging morphologies of benign and malignant lymph nodes according to the different imaging techniques will be delineated.
  • Imaging examples of the different modalities of benign and malignant transformed lymph nodes will be demonstrated.
  • Furthermore, the diagnostic sensitivity of each modality will be delineated and further aspects of modern lymph node staging of the head and neck region such as those with special contrast agents will be described.
  • Also the value of biopsy techniques including recently developed ultrasonography guided needle biopsy with molecular analysis of the cells of about 97-100% accuracy in diagnosing benign from malignant lymph nodes will be mentioned.
  • Overall, the reader will get an overview of the present imaging modalities to potentially stage correctly lymph nodes in the head and neck region to facilitate the therapeutic procedure.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Lymph Nodes / pathology
  • [MeSH-minor] Biopsy, Needle / methods. Contrast Media / administration & dosage. Diagnosis, Differential. Ferric Compounds. Humans. Image Enhancement / methods. Lymphatic Metastasis. Magnetic Resonance Imaging / methods. Medical Illustration. Neoplasm Staging. Sensitivity and Specificity. Tomography, X-Ray Computed / methods. Ultrasonography, Doppler, Color / methods

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  • (PMID = 16687230.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Ferric Compounds; 1K09F3G675 / ferric oxide
  • [Number-of-references] 28
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37. Christein JD, Smoot RL, Farnell MB: Central pancreatectomy: a technique for the resection of pancreatic neck lesions. Arch Surg; 2006 Mar;141(3):293-9
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  • [Title] Central pancreatectomy: a technique for the resection of pancreatic neck lesions.
  • Although historically used for traumatic pancreatic transection and chronic pancreatitis, it currently is reserved for selective management of pancreatic neck lesions that are benign or have low malignant potential.
  • Our objectives were to describe the technique and determine the safety and effectiveness of central pancreatectomy in the excision of benign or low-malignant potential lesions of the pancreatic neck.
  • INTERVENTION: Patients with pancreatic neck or proximal body masses underwent central pancreatectomy at the Mayo Clinic, Rochester, Minn.
  • RESULTS: Abnormalities included 3 islet cell tumors, 2 serous cystadenomas, a mucinous cystadenoma, a lymphoepithelial cyst, and a recurrent liposarcoma.
  • Mean tumor size was 2.8 cm and mean operative time was 4.8 hours with a mean blood loss of 381 mL.
  • Caution is necessary when using central pancreatectomy in the treatment of pancreatic neck lesions.
  • The precise role of central pancreatectomy in the management of benign or low-malignant potential lesions of the neck of the pancreas remains in evolution.
  • [MeSH-minor] Adenoma, Islet Cell / radiography. Adenoma, Islet Cell / surgery. Cystadenoma, Serous / radiography. Cystadenoma, Serous / surgery. Female. Humans. Liposarcoma / surgery. Male. Mesenteric Veins / surgery. Middle Aged. Neoplasm Recurrence, Local / surgery. Reoperation. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 16549696.001).
  • [ISSN] 0004-0010
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Baradaranfar MH, Dabirmoghaddam P: Endoscopic endonasal surgery for resection of benign sinonasal tumors: experience with 105 patients. Arch Iran Med; 2006 Jul;9(3):244-9
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  • [Title] Endoscopic endonasal surgery for resection of benign sinonasal tumors: experience with 105 patients.
  • OBJECTIVE: To report our experience with endoscopic surgery of benign tumors and tumor-like conditions of the nose and paranasal sinuses.
  • METHODS: The medical records of 105 patients with benign sinonasal tumor, who had undergone endoscopic surgery for removal of their neoplasm between 1997 and 2003, were retrospectively studied.
  • RESULTS: The studied patients included 32 with juvenile nasopharyngeal angiofibroma, 24 with inverted papilloma, 23 with benign fibroosseous lesions, 18 with pyogenic granuloma, 6 with intranasal hemangioma, and 2 with pleomorphic adenoma.
  • Eight cases of recurrent tumor--2 angiofibroma, 4 inverted papilloma, 1 fibrous dysplasia, and 1 osteoma--were noted and managed endoscopically alone or in combination with Caldwell-Luc approach.
  • CONCLUSION: Endoscopic surgery is a valuable tool for removal of benign tumors of the nose and paranasal sinuses in the hands of an experienced surgeon.

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  • (PMID = 16859060.001).
  • [ISSN] 1029-2977
  • [Journal-full-title] Archives of Iranian medicine
  • [ISO-abbreviation] Arch Iran Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Iran
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39. Kohl SK, Simpson RJ, Wisecarver J: Chondroid metaplasia mimicking recurrent squamous cell carcinoma of the head and neck. Ear Nose Throat J; 2009 Jan;88(1):E4
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  • [Title] Chondroid metaplasia mimicking recurrent squamous cell carcinoma of the head and neck.
  • She had a history of squamous cell carcinoma of the head and neck that had been treated with surgery and radiotherapy 11 years earlier.
  • The tongue lesion was excised, and pathologic examination identified a submucosal focus of benign-appearing cartilage.
  • Chondroid metaplasia involving the head and neck is rare.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Neoplasm Recurrence, Local / pathology. Tongue Neoplasms / secondary. Tonsillar Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy, Needle. Cartilage / pathology. Combined Modality Therapy. Diagnosis, Differential. Female. Follow-Up Studies. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / therapy. Humans. Immunohistochemistry. Metaplasia / pathology. Neck Dissection / methods. Radiotherapy, Adjuvant. Risk Assessment. Tonsillectomy / methods

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  • (PMID = 19172559.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Gleason BC, Fletcher CD: Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential. Am J Surg Pathol; 2008 Mar;32(3):354-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential.
  • Benign fibrous histiocytoma (FH) is one of the most common mesenchymal neoplasms of the skin.
  • Deep benign FH is an uncommon and poorly recognized clinical subtype that arises in subcutaneous or deep soft tissue.
  • The most common anatomic location was the extremities (58%); the remainder arose on the head and neck (22%), trunk (11%), and in the deep soft tissue of the retroperitoneum, mediastinum, or pelvis (9%).
  • The tumors ranged from 0.5 to 25 cm in size (median, 3.0 cm) and were well circumscribed grossly and microscopically.
  • All tumors were composed of bland ovoid to spindle cells arranged in a storiform pattern with admixed lymphocytes.
  • Of the 37 patients for whom clinical follow-up was available (median, 40 mo), 8 (22%) had a local recurrence; in all 8 cases, the tumor had been marginally or incompletely excised.
  • The metastasizing tumors were large (6 and 9 cm) and 1 had tumor necrosis but they were otherwise histologically identical to the nonmetastasizing lesions.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Neoplasm Metastasis / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Actins / analysis. Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD34 / analysis. Child. Desmin / analysis. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mitosis. Necrosis. Neoplasm Recurrence, Local

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  • (PMID = 18300816.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD34; 0 / Desmin
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41. Subbiah S, Collins BJ, Schneider AB: Factors related to the recurrence of thyroid nodules after surgery for benign radiation-related nodules. Thyroid; 2007 Jan;17(1):41-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Factors related to the recurrence of thyroid nodules after surgery for benign radiation-related nodules.
  • OBJECTIVE: Benign thyroid nodules are increased by radiation exposure and recurrences are common.
  • DESIGN, SETTING, AND SUBJECTS: The study population was drawn from a cohort of 4296 people treated before the age of 16 with conventional external radiation for benign conditions of the head and neck between 1939 and the early 1960s.
  • The study group consisted of 632 subjects who had benign nodules removed surgically.
  • [MeSH-major] Neoplasm Recurrence, Local / epidemiology. Thyroid Neoplasms. Thyroid Nodule

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  • (PMID = 17274748.001).
  • [ISSN] 1050-7256
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 21518
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 9002-71-5 / Thyrotropin; Q51BO43MG4 / Thyroxine
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42. Gourin CG, Watts T, Williams HT, Patel VS, Bilodeau PA, Coleman TA: Identification of distant metastases with PET-CT in patients with suspected recurrent head and neck cancer. Laryngoscope; 2009 Apr;119(4):703-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Identification of distant metastases with PET-CT in patients with suspected recurrent head and neck cancer.
  • OBJECTIVES: To investigate the utility of positron-emission tomography/computed tomography (PET-CT) in identifying distant metastatic disease in patients with suspected recurrent head and neck squamous cell cancer (HNSCC).
  • There was a significant correlation between standardized uptake value (SUV) on PET-CT and positive histology, with a mean SUV of 8.5 (range, 4.7-16.2) in patients with distant metastases compared with a mean SUV of 2.9 (range, 1.9-4.2) in patients with benign pathology (r = 0.87, P < .0001).
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Female. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / surgery. Humans. Incidence. Male. Middle Aged. Neoplasm Recurrence, Local / radiography. Neoplasm Recurrence, Local / radionuclide imaging. Positron-Emission Tomography. Preoperative Care. Radiotherapy, Adjuvant. Retrospective Studies. Salvage Therapy. Sensitivity and Specificity. Tomography, X-Ray Computed

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  • (PMID = 19205017.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Papaspyrou K, Mann WJ, Amedee RG: Management of head and neck paragangliomas: review of 120 patients. Head Neck; 2009 Mar;31(3):381-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of head and neck paragangliomas: review of 120 patients.
  • BACKGROUND: Head and neck paragangliomas (PGL) are rare, mostly benign tumors.
  • METHODS AND RESULTS: A retrospective review of 120 patients with 146 head and neck PGL, including 46 carotid body tumors (CBT), 13 vagal tumors, 55 jugulotympanic tumors (JTT), 25 tympanic tumors (TT) and 7 tumors in other locations are included.
  • CONCLUSION: According to our experience, the treatment of PGL must be individualized, taking into account the patient's age, medical condition, tumor site and size, multiple occurrences, and preexisting cranial nerve deficits.
  • Tumor control is high whether treatment is by surgery or radiotherapy.
  • [MeSH-major] Head and Neck Neoplasms / therapy. Outcome Assessment (Health Care). Paraganglioma / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carotid Artery, Internal. Child. Cranial Nerve Diseases / etiology. Deafness / etiology. Deafness / prevention & control. Embolization, Therapeutic. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Postoperative Complications. Radiotherapy, Adjuvant. Retrospective Studies. Young Adult

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  • (PMID = 18972432.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. Wang CP, Lee YC, Lou PJ, Yang TL, Chen TC, Huang CC, Ko JY: Unsedated transnasal esophagogastroduodenoscopy for the evaluation of dysphagia following treatment for previous primary head neck cancer. Oral Oncol; 2009 Jul;45(7):615-20
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  • [Title] Unsedated transnasal esophagogastroduodenoscopy for the evaluation of dysphagia following treatment for previous primary head neck cancer.
  • Dysphagia is not uncommon after curative treatment for primary head and neck cancer.
  • The purpose of this study was to prospectively investigate the diagnostic value of unsedated transnasal esophagogastroduodenoscopy (EGD) in 36 primary head and neck cancer patients with post-treatment dysphagia.
  • Except three patients with very narrow space or the presence of the tumor in the neopharynx, transnasal EGD could completely evaluate the upper digestive tract in 33 patients and found one patient with local recurrent hypopharyngeal cancer, seven patients with newly diagnosed hypopharyngeal cancer, four patients with esophageal cancer, and one patient with simultaneous hypopharyngeal and esophageal cancers, which were all successfully biopsied and proven microscopically.
  • One patient had a benign tumor on the epiglottis and the other NPC patient had extensive soft tissue necrosis in the pyriform sinus as a cause of dysphagia.
  • The present study indicates that unsedated transnasal EGD is feasible to confidently distinguish between functionally/anatomically-related dysphagia and newly growing tumors in the upper digestive tract, and to obtain biopsy specimens for pathological diagnosis from the tumors in a single session.
  • [MeSH-major] Deglutition Disorders / diagnosis. Endoscopy, Digestive System / methods. Esophageal Neoplasms / diagnosis. Hypopharyngeal Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Conscious Sedation. Feasibility Studies. Female. Head and Neck Neoplasms / pathology. Humans. Male. Middle Aged. Prospective Studies. Taiwan

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  • (PMID = 19027351.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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45. Ozawa H, Tomita T, Sakamoto K, Tagawa T, Fujii R, Kanzaki S, Ogawa K, Kameyama K, Fujii M: Mucoepidermoid carcinoma of the head and neck: clinical analysis of 43 patients. Jpn J Clin Oncol; 2008 Jun;38(6):414-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucoepidermoid carcinoma of the head and neck: clinical analysis of 43 patients.
  • While the high-grade type is a highly aggressive tumor, its low-grade counterpart usually demonstrates a more benign nature and several systems have, therefore, been proposed to grade this neoplasm.
  • METHODS: This report analyzes 43 patients suffering from head and neck MEC, who were treated in our department during the period from 1989 to 2005.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Carcinoma, Mucoepidermoid / therapy. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / therapy
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Analysis of Variance. Disease-Free Survival. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Predictive Value of Tests. Prognosis. Proportional Hazards Models. Radiotherapy, Adjuvant. Retrospective Studies. Salivary Gland Neoplasms / therapy. Sex Factors. Treatment Outcome

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  • (PMID = 18573852.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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46. Sakamoto K, Ono T, Nakamura Y, Harada H, Nakashima T: Expression of cluster of differentiation 9 glycoprotein in benign and malignant parotid gland tumours. J Laryngol Otol Suppl; 2009;(31):58-63

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of cluster of differentiation 9 glycoprotein in benign and malignant parotid gland tumours.
  • Regarding benign parotid gland tumours, cluster of differentiation 9 glycoprotein was present in 13 of 18 pleomorphic adenomas, in all Warthin tumours tested (21/21) and in all cases of basal cell adenoma tested (four of four).
  • CONCLUSIONS: There was a statistically significantly reduced expression of cluster of differentiation 9 glycoprotein in malignant parotid gland tumours, compared with benign parotid gland tumours (p < 0.05).
  • [MeSH-major] Antigens, CD / analysis. Membrane Glycoproteins / analysis. Neoplasm Proteins / analysis. Parotid Gland / chemistry. Parotid Neoplasms / chemistry

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  • (PMID = 19460206.001).
  • [ISSN] 0144-2945
  • [Journal-full-title] The Journal of laryngology and otology. Supplement
  • [ISO-abbreviation] J Laryngol Otol Suppl
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD9; 0 / CD9 protein, human; 0 / Membrane Glycoproteins; 0 / Neoplasm Proteins
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47. Supriya M, Denholm S, Palmer T: Seeding of tumor cells after fine needle aspiration cytology in benign parotid tumor: a case report and literature review. Laryngoscope; 2008 Feb;118(2):263-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Seeding of tumor cells after fine needle aspiration cytology in benign parotid tumor: a case report and literature review.
  • However, some authors have raised concerns regarding the possibility of tumor cell seeding along the needle track.
  • We present to our knowledge the first case of tumor seeding after FNAC of a benign parotid tumor.
  • This is followed by a review of the literature on tumor seeding after aspiration with fine needles of 20 gauge and smaller and the implications for clinical practice.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Biopsy, Fine-Needle / adverse effects. Neoplasm Seeding. Parotid Neoplasms / pathology

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  • (PMID = 18030170.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 11
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48. Ferris RL, Xi L, Raja S, Hunt JL, Wang J, Gooding WE, Kelly L, Ching J, Luketich JD, Godfrey TE: Molecular staging of cervical lymph nodes in squamous cell carcinoma of the head and neck. Cancer Res; 2005 Mar 15;65(6):2147-56
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  • [Title] Molecular staging of cervical lymph nodes in squamous cell carcinoma of the head and neck.
  • Clinical staging of cervical lymph nodes from patients with squamous cell carcinoma of the head and neck (SCCHN) has only 50% accuracy compared with definitive pathologic assessment.
  • Consequently, both clinically positive and clinically negative patients frequently undergo neck dissections that may not be necessary.
  • To address this potential overtreatment, sentinel lymph node (SLN) biopsy is currently being evaluated to provide better staging of the neck.
  • Seven markers were identified with good characteristics for identifying metastatic disease, and these were validated using a set of 26 primary tumors, 19 histologically positive lymph nodes, and 21 benign nodes from patients without cancer.
  • Four markers discriminated between positive and benign nodes with accuracy >97% but only one marker, pemphigus vulgaris antigen (PVA), discriminated with 100% accuracy in both the observed data and a statistical bootstrap analysis.
  • The automated analysis with PVA provided perfect discrimination between histologically positive and benign lymph nodes and correctly identified two lymph nodes with micrometastatic tumor deposits.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Head and Neck Neoplasms / pathology. Lymph Nodes / pathology. Reverse Transcriptase Polymerase Chain Reaction / methods. Sentinel Lymph Node Biopsy / methods
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 15781625.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA90665-01
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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49. Roh JL, Ryu CH, Kim JS, Lee JS, Choi SH, Nam SY, Kim SY: Clinical significance of intrathoracic lesions detected by 18F-fluorodeoxyglucose positron emission tomography in the management of patients with head and neck cancer. Oral Oncol; 2007 Sep;43(8):757-63
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  • [Title] Clinical significance of intrathoracic lesions detected by 18F-fluorodeoxyglucose positron emission tomography in the management of patients with head and neck cancer.
  • Few studies have used positron emission tomography (PET) to identify metastases or simultaneous thoracic malignancies in patients with head and neck cancer (HNC).
  • Most of the lesions (83%) with abnormal FDG uptake were benign, with thoracic malignancy confirmed in 15 patients (17%).
  • [MeSH-major] Head and Neck Neoplasms / pathology. Lung Neoplasms / radionuclide imaging. Lung Neoplasms / secondary. Mediastinal Neoplasms / radionuclide imaging. Mediastinal Neoplasms / secondary. Positron-Emission Tomography
  • [MeSH-minor] Adolescent. Adult. Aged. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / radiography. Carcinoma, Squamous Cell / radionuclide imaging. Carcinoma, Squamous Cell / secondary. Female. Fluorodeoxyglucose F18. Humans. Image Interpretation, Computer-Assisted / methods. Male. Middle Aged. Neoplasm Staging. Radiopharmaceuticals. Retrospective Studies. Risk Factors. Sensitivity and Specificity. Tomography, X-Ray Computed

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  • (PMID = 17112773.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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50. Liu FH, Hsueh C, Chao TC, Lin JD: Neck nodule and thyroid cancer in young without radiation exposure history. Pediatr Surg Int; 2009 Sep;25(9):785-8
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  • [Title] Neck nodule and thyroid cancer in young without radiation exposure history.
  • PURPOSE: The aim of this study was to analyze the results of histopathological studies in neck masses observed in young patients.
  • The neck masses were detected using ultrasonography and fine-needle aspiration cytology (FNAC).
  • METHODS: In this retrospective study, we analyzed 234 young patients who were surgically treated for neck masses at Chang Gung Medical Center in Linkou.
  • Neck ultrasonography studies were conducted using a real-time ultrasonographic machine and a 10 MHz transducer.
  • FNAC was performed for the suspected neck nodules.
  • RESULTS: Of the 234 cases, 187 (79.9%) were surgically confirmed to be benign lesions, including four cases that were diagnosed as atypical adenoma.
  • CONCLUSIONS: In the study population, 20.1% of the neck masses were malignant.
  • Except in cases of follicular thyroid neoplasm, neck ultrasonography with FNAC could effectively identify the thyroid or non-thyroid origin of these masses with high-diagnostic accuracy.
  • [MeSH-major] Head and Neck Neoplasms / pathology
  • [MeSH-minor] Adenoma / pathology. Adolescent. Biopsy, Fine-Needle. Carcinoma / pathology. Child. Child, Preschool. Cysts / pathology. Female. Hemangioma, Capillary / pathology. Humans. Infant. Lymphoma / pathology. Male. Neck / diagnostic imaging. Neurofibroma / pathology. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity. Thyroiditis / pathology. Ultrasonography. Young Adult

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  • (PMID = 19629501.001).
  • [ISSN] 1437-9813
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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51. Durgun Y, Firat C, Miman MC, Kirimlioglu H: A rare benign laryngeal tumor: angiomyolipoma. J Craniofac Surg; 2010 Nov;21(6):1956-7

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  • [Title] A rare benign laryngeal tumor: angiomyolipoma.
  • Angiomyolipoma is a mesenchymal neoplasm containing adipose tissue, blood vessels, and smooth muscle fibers.
  • Arising most frequently in the kidney, the tumor may exceptionally be at the head and neck region.
  • The tumor was removed by an endolaryngeal approach.

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  • (PMID = 21119467.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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52. Pham NS, Poirier B, Fuller SC, Dublin AB, Tollefson TT: Pediatric lipoblastoma in the head and neck: a systematic review of 48 reported cases. Int J Pediatr Otorhinolaryngol; 2010 Jul;74(7):723-8
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  • [Title] Pediatric lipoblastoma in the head and neck: a systematic review of 48 reported cases.
  • BACKGROUND: Lipoblastoma is an exceedingly rare cause of pediatric head and neck masses.
  • We present an additional case and review of the available literature on this rare neoplasm.
  • MEDLINE was searched for the terms "neonatal lipoblastoma", "lipoblastomatosis", and "benign lipoblastoma".
  • RESULTS: Including our new case, a total of 48 cases of head and neck lipoblastoma have been reported in the English literature within 23 manuscripts.
  • The most common presenting symptoms were painless enlarging neck mass (53%, 17/32) and respiratory distress (12%, 4/32).
  • CONCLUSIONS: Our findings suggest that although total excision is ideal and curative, subtotal resection may be a viable treatment alternative for lipoblastoma of the head and neck.
  • This tumor presents a clinical challenge and should be considered in infants presenting with a cervical mass.
  • Nonetheless, recurrence rates for head and neck lipoblastomas are similar to those rates observed elsewhere in the body.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Lipoma / pathology
  • [MeSH-minor] Female. Humans. Infant. Infant, Newborn. Magnetic Resonance Imaging. Neoplasm Recurrence, Local. Respiratory Distress Syndrome, Newborn / etiology

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  • [Copyright] Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20472310.001).
  • [ISSN] 1872-8464
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Ireland
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53. Ryś J, Kruczak A, Marczyk E, Skotnicki P, Moskal J, Ambicka A, Harazin-Lechowska A, Wasilewska A, Vogelgesang M, Dyczek S: Primary soft tissue giant cell tumour of the neck. Cytological and histological characteristics of the tumour and differential diagnosis. Pol J Pathol; 2009;60(2):98-104; quiz 105
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  • [Title] Primary soft tissue giant cell tumour of the neck. Cytological and histological characteristics of the tumour and differential diagnosis.
  • Giant cell tumour of soft part is a very rare neoplasm.
  • The deep-situated giant cell tumours of the neck are extremely rare.
  • That is why we report a case of primary giant cell tumour of soft part localized in the trapezius muscle of a 19-year-old woman.
  • We present both cytological and histological picture of the neoplasm.
  • [MeSH-major] Giant Cell Tumors / pathology. Head and Neck Neoplasms / pathology. Muscle, Skeletal / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Osteosarcoma / diagnosis. Sarcoma, Synovial / diagnosis. Synovitis, Pigmented Villonodular / diagnosis. Treatment Outcome. Young Adult

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  • (PMID = 19886185.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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54. Goshen E, Davidson T, Yahalom R, Talmi YP, Zwas ST: PET/CT in the evaluation of patients with squamous cell cancer of the head and neck. Int J Oral Maxillofac Surg; 2006 Apr;35(4):332-6
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  • [Title] PET/CT in the evaluation of patients with squamous cell cancer of the head and neck.
  • The purpose of this study was to compare the findings of positron emission tomography (PET) with fused PET and computed tomography (CT) in patients with suspected locoregional and distant head and neck cancer and to evaluate the impact of those findings on clinical management.
  • PET findings were classified as malignant, benign or equivocal.
  • The negative predictive value was 100% in this combined group of patients with locoregional and distant head and neck cancer.
  • PET/CT is highly contributory for initial staging and in the evaluation of patients with suspected recurrent SCC of the head and neck, in whom anatomic imaging is inconclusive due to the locoregional distortions rendered by surgery and radiotherapy.
  • [MeSH-major] Head and Neck Neoplasms / radiography. Head and Neck Neoplasms / radionuclide imaging. Neoplasm Recurrence, Local / radiography. Neoplasm Recurrence, Local / radionuclide imaging. Positron-Emission Tomography / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 16280234.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
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55. Hafidh MA, Lacy PD, Hughes JP, Duffy G, Timon CV: Evaluation of the impact of addition of PET to CT and MR scanning in the staging of patients with head and neck carcinomas. Eur Arch Otorhinolaryngol; 2006 Sep;263(9):853-9
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  • [Title] Evaluation of the impact of addition of PET to CT and MR scanning in the staging of patients with head and neck carcinomas.
  • The addition of whole body positron emission tomography (PET) to the investigation of patients with newly diagnosed head and neck squamous cell carcinoma (HNSCC) was assessed over a 6-month period.
  • SUV levels above 5 were considered indicative of the presence of tumour, values below 3 indicative of benign aetiology and values equal to and between 3 and 5 were considered equivocal.
  • Three patients presenting with neck disease had unknown primary tumours.
  • Thirty-two patients underwent neck dissection.
  • None of the three imaging modalities was able to identify the tumour site in the three patients with unknown primaries.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Head and Neck Neoplasms / pathology. Magnetic Resonance Imaging / methods. Positron-Emission Tomography / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prospective Studies. ROC Curve. Sensitivity and Specificity

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  • (PMID = 16724209.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
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56. Razek AA: Diffusion-weighted magnetic resonance imaging of head and neck. J Comput Assist Tomogr; 2010 Nov-Dec;34(6):808-15
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  • [Title] Diffusion-weighted magnetic resonance imaging of head and neck.
  • Our aim was to review the clinical applications of diffusion-weighted magnetic resonance imaging in the head and neck.
  • Diffusion-weighted magnetic resonance imaging plays a role in the differentiation of benign from malignant head and neck tumors, squamous cell carcinoma from lymphoma, and metastatic from benign lymphadenopathy as well as in the selection of the biopsy site.
  • It can be used for the differentiation of recurrent tumors from posttreatment changes and in monitoring the patient after radiotherapy.
  • It helps in the differentiation of necrotic tumors from abscesses.
  • [MeSH-major] Diffusion Magnetic Resonance Imaging / methods. Head and Neck Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Echo-Planar Imaging. Humans. Image Enhancement / methods. Lymphatic Metastasis. Neoplasm Recurrence, Local / diagnosis. Neoplasm Staging

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  • (PMID = 21084893.001).
  • [ISSN] 1532-3145
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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57. Vandecaveye V, De Keyzer F, Hermans R: Diffusion-weighted magnetic resonance imaging in neck lymph adenopathy. Cancer Imaging; 2008;8:173-80
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  • [Title] Diffusion-weighted magnetic resonance imaging in neck lymph adenopathy.
  • In patients with head and neck squamous cell carcinoma (SCC), nodal metastases are an adverse prognostic factor compromising long term patient survival.
  • Computed tomography (CT) and magnetic resonance imaging (MRI) remain the primary imaging modalities for locoregional staging of head and neck SCC.
  • Next to evaluation of the primary tumour, both modalities facilitate detection of non-palpable lymph nodes (LN).
  • However, both modalities rely on size-related and morphological criteria to differentiate between benign and malignant lymph nodes, decreasing the sensitivity for detection of small metastases.
  • The added value of DW-MRI to conventional imaging for staging of lymph nodes in head and neck cancer is discussed, before and after treatment.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / secondary. Diffusion Magnetic Resonance Imaging / methods. Echo-Planar Imaging / methods. Head and Neck Neoplasms / diagnosis. Lymph Nodes / pathology. Lymphatic Diseases / pathology
  • [MeSH-minor] Biopsy, Needle. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Immunohistochemistry. Lymphatic Metastasis. Male. Neck / pathology. Neoplasm Staging. Postoperative Care / methods. Preoperative Care / methods. Radiotherapy, Adjuvant. Sensitivity and Specificity. Surgical Procedures, Operative / methods. Survival Rate. Treatment Outcome

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  • (PMID = 18824423.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 27
  • [Other-IDs] NLM/ PMC2556503
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58. Muenscher A, Diegel T, Jaehne M, Ussmüller J, Koops S, Sanchez-Hanke M: Benign and malignant salivary gland diseases in children A retrospective study of 549 cases from the Salivary Gland Registry, Hamburg. Auris Nasus Larynx; 2009 Jun;36(3):326-31
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  • [Title] Benign and malignant salivary gland diseases in children A retrospective study of 549 cases from the Salivary Gland Registry, Hamburg.
  • OBJECTIVE: Tumors of salivary glands in children are rare.
  • The incidences of salivary gland tumors in children (0-14 years) differ completely from those in adults.
  • Most of the specimens were presented by the Clinic for Otorhinolaryngology and Head and Neck Surgery, University Hamburg, Eppendorf.
  • RESULTS: This study will give a detailed survey of salivary gland diseases and tumors in children up to the age of 14 which have undergone surgical therapy/biopsy.
  • We present the general distribution of the different tumors/diseases, the distribution in certain age groups and the various locations.
  • Comparing the distribution of malignant tumors with other studies, the epithelial-myoepithelial carcinomas followed by salivary duct carcinomas represent the largest group in childhood.
  • CONCLUSIONS: The study shows that comparing to adulthood different tumors play an important role in adolescence.
  • The distribution of tumors in childhood may help in diagnostic.
  • [MeSH-minor] Adolescent. Biopsy. Catchment Area (Health). Child. Child, Preschool. Female. Germany / epidemiology. Humans. Infant. Infant, Newborn. Male. Neoplasm Staging. Retrospective Studies

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  • (PMID = 18809268.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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59. Wu J, Rosenbaum E, Begum S, Westra WH: Distribution of BRAF T1799A(V600E) mutations across various types of benign nevi: implications for melanocytic tumorigenesis. Am J Dermatopathol; 2007 Dec;29(6):534-7
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  • [Title] Distribution of BRAF T1799A(V600E) mutations across various types of benign nevi: implications for melanocytic tumorigenesis.
  • The rate varied only slightly by anatomic site: BRAF mutations were detected in 21 of 21 (100%) nevi of the head and neck, 62 of 76 (82%) nevi of the trunk, 8 of 14 (62%) nevi of the extremities, and 18 of 24 (75%) anogenital nevi.
  • [MeSH-minor] Adolescent. Adult. Aged. Anus Neoplasms / genetics. Anus Neoplasms / pathology. Anus Neoplasms / surgery. Back / pathology. Child. DNA Mutational Analysis. DNA, Neoplasm / analysis. Extremities / pathology. Female. Head and Neck Neoplasms / genetics. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / surgery. Humans. Male. Microdissection. Middle Aged. Urogenital Neoplasms / genetics. Urogenital Neoplasms / pathology. Urogenital Neoplasms / surgery

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  • (PMID = 18032947.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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60. Vranic S, Caughron SK, Djuricic S, Bilalovic N, Zaman S, Suljevic I, Lydiatt WM, Emanuel J, Gatalica Z: Hamartomas, teratomas and teratocarcinosarcomas of the head and neck: Report of 3 new cases with clinico-pathologic correlation, cytogenetic analysis, and review of the literature. BMC Ear Nose Throat Disord; 2008;8:8

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  • [Title] Hamartomas, teratomas and teratocarcinosarcomas of the head and neck: Report of 3 new cases with clinico-pathologic correlation, cytogenetic analysis, and review of the literature.
  • BACKGROUND: Germ-cell tumors (GCT) are a histologically and biologically diverse group of neoplasms which primarily occur in the gonads but also develop at different extragonadal sites in the midline of the body.
  • The head and neck region including the upper respiratory tract is a very rare location for such tumors in both children and adults, which can cause diagnostic and therapeutic difficulties.
  • METHODS: We describe here two new cases of multilineage tumors including sinonasal teratocarcinosarcoma [SNTCS], and congenital oronasopharyngeal teratoma (epignathus) and compare their features with those of a new case of a rare salivary gland anlage tumor [SGAT], an entity for which the pathogenesis is unclear (i.e. hamartoma versus neoplasm).
  • Both cytogenetic abnormalities are characteristically present in malignant germ cell tumors providing for the first time evidence that this rare tumor type indeed might represent a variant of a germ cell neoplasm.
  • The SGAT and epignathus carried no such cytogenetic abnormalities, in keeping with their limited and benign biologic potential.
  • CONCLUSION: The comparison of these three cases should serve to emphasize the diversity of multilineage tumors (hamartomas and GCT) of the upper respiratory tract in regards to their biology, age of presentation and clinical outcomes.
  • Malignant tumors of germ cell origins are more likely to affect adults with insidious symptom development, while benign tumors can nevertheless cause dramatic clinical symptoms which, under certain circumstances, can be fatal.

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  • (PMID = 19025657.001).
  • [ISSN] 1472-6815
  • [Journal-full-title] BMC ear, nose, and throat disorders
  • [ISO-abbreviation] BMC Ear Nose Throat Disord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2611960
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61. Aarstad HJ, Aarstad AK, Heimdal JH, Olofsson J: Mood, anxiety and sense of humor in head and neck cancer patients in relation to disease stage, prognosis and quality of life. Acta Otolaryngol; 2005 May;125(5):557-65
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  • [Title] Mood, anxiety and sense of humor in head and neck cancer patients in relation to disease stage, prognosis and quality of life.
  • OBJECTIVE: To study the association between anxiety score, depression level at sense of humor at diagnosis in head and neck squamous cell carcinoma (HNSCC) patients versus TNM stage, prognosis and depression level/quality of life (QOL) 6 years following diagnosis.
  • A control group of patients with benign HN disease was also included.
  • MATERIAL AND METHODS: Male patients with newly diagnosed HNSCC (n =78) or benign HN (n =61) disease completed the following questionnaires: the Beck Depression Inventory, the Spielberger Trait Anxiety Inventory (state) and the Svebak humor questionnaire.
  • [MeSH-minor] Female. Humans. Male. Middle Aged. Neoplasm Staging. Psychometrics. Quality of Life. Severity of Illness Index


62. Zhou M, Reuther AM, Levin HS, Falzarano SM, Kodjoe E, Myles J, Klein E, Magi-Galluzzi C: Microscopic bladder neck involvement by prostate carcinoma in radical prostatectomy specimens is not a significant independent prognostic factor. Mod Pathol; 2009 Mar;22(3):385-92
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  • [Title] Microscopic bladder neck involvement by prostate carcinoma in radical prostatectomy specimens is not a significant independent prognostic factor.
  • The independent prognostic importance of microscopic bladder neck involvement by prostate cancer in radical prostatectomy is questionable.
  • We studied a cohort of 1845 patients to determine the significance of microscopic bladder neck involvement.
  • Bladder neck involvement was defined as prostate cancer present within the coned bladder neck.
  • We further categorized the cases as 'true bladder neck involvement' and 'false bladder neck involvement.
  • ' True bladder neck involvement required prostate cancer within thick smooth muscle bundles without intermixed benign prostatic glands.
  • False bladder neck involvement was characterized by prostate cancer intermixed with benign prostatic glands.
  • Bladder neck involvement was analyzed in relation to preoperative serum prostate-specific antigen (PSA) level, extraprostatic extension, seminal vesicle involvement, positive surgical margin, lymph node involvement, radical prostatectomy Gleason score, and tumor volume.
  • Of the 90 patients (4.9%) with microscopic bladder neck involvement, 63 were further classified as true bladder neck involvement and 27 as false bladder neck involvement.
  • In univariate model, both types of bladder neck involvement (P<0.001), true (P<0.001), and false (P=0.040), were significantly associated with increased PSA-recurrence risk compared to bladder neck negative cases.
  • In multivariate model the PSA-recurrence relative risk associated with bladder neck involvement (true or false) was not a significant independent prognostic factor.
  • The time to biochemical recurrence in patients with bladder neck involvement was similar to that of pT2 with positive surgical margin or pT3a with negative surgical margin patients (Kaplan-Meier curves).
  • Bladder neck involvement was associated with other adverse pathologic features, but was not an independent predictor of PSA recurrence.
  • In view of the previous and current data, the staging system for bladder neck involvement should be revised and patients may be best categorized as having pT3a disease.
  • [MeSH-minor] Aged. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Prognosis. Prostate-Specific Antigen / blood. Prostatectomy

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  • (PMID = 19043400.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen
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63. Nakamura T, Sumi M: Nodal imaging in the neck: recent advances in US, CT and MR imaging of metastatic nodes. Eur Radiol; 2007 May;17(5):1235-41
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  • [Title] Nodal imaging in the neck: recent advances in US, CT and MR imaging of metastatic nodes.
  • The presence of lymph node metastasis in the neck in patients with head and neck cancer is an important prognostic determinant in staging cancers and in planning surgery and chemo- and radiotherapy for the cancer patients.
  • Therefore, metastatic nodes should be effectively differentiated from benign lymphadenopathies and nodal lymphomas.
  • Here, we review recent advances in the diagnostic imaging of metastatic nodes in the neck, with emphasis placed on the diagnostic performance of MR imaging, Doppler sonography, and CT.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Lymph Nodes / pathology. Lymphatic Metastasis / diagnosis
  • [MeSH-minor] Contrast Media. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Neoplasm Staging. Tomography, X-Ray Computed. Ultrasonography, Doppler

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  • (PMID = 17252236.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 45
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64. Yoshimura Y, Nariai Y, Obara S, Mishima K, Yoshimura H, Maruyama R: Development or existence of non-metastatic lymph nodes in the previously operated neck: a good prognostic sign for oromaxillary squamous cell carcinoma? Oral Oncol; 2005 Apr;41(4):404-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Development or existence of non-metastatic lymph nodes in the previously operated neck: a good prognostic sign for oromaxillary squamous cell carcinoma?
  • The aim of this study is to clarify the clinicopathological features of patients having non-metastatic lymph nodes in the previously operated neck for oromaxillary squamous cell carcinoma (OSCC).
  • The clinicopathological factors of 9 such patients were comparatively analyzed with those of 78 other patients who underwent neck dissection (ND).
  • In conclusion, the occurrence of benign hyperplastic lymph nodes in the previously operated neck region suggested favorable prognosis, though the immunological mechanism is not understood.
  • [MeSH-minor] Aged. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neck Dissection. Neoplasm Staging. Prognosis. Retrospective Studies. Treatment Outcome

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  • (PMID = 15792613.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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65. Strobel K, Haerle SK, Stoeckli SJ, Schrank M, Soyka JD, Veit-Haibach P, Hany TF: Head and neck squamous cell carcinoma (HNSCC)--detection of synchronous primaries with (18)F-FDG-PET/CT. Eur J Nucl Med Mol Imaging; 2009 Jun;36(6):919-27
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  • [Title] Head and neck squamous cell carcinoma (HNSCC)--detection of synchronous primaries with (18)F-FDG-PET/CT.
  • PURPOSE: The aim of the study was to evaluate (18)F-FDG-PET/CT for the detection of synchronous primaries at initial staging of patients with head and neck squamous cell carcinoma (HNSCC).
  • Of the 56 second cancers, 46 (82%) were found in the aerodigestive tract in the following locations: lung (26, 46%), head and neck (15, 17%), oesophagus (5, 9%).
  • Nine synchronous cancers were not detected by PET/CT (four head and neck, two lung, two oesophageal, one gastric).
  • False-positive PET/CT findings were mainly related to benign FDG uptake in the intestine due to benign or precancerous polyps or physiological FDG uptake in other head and neck regions.
  • Synchronous cancers were predominantly located in the aerodigestive tract, primarily in the lung, head and neck and oesophagus.
  • [MeSH-major] Fluorodeoxyglucose F18. Head and Neck Neoplasms / diagnostic imaging. Neoplasms, Multiple Primary / diagnostic imaging. Neoplasms, Squamous Cell / diagnostic imaging
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. False Positive Reactions. Female. Humans. Male. Middle Aged. Neoplasm Staging. Neoplasms, Second Primary / diagnostic imaging. Neoplasms, Second Primary / pathology. Neoplasms, Second Primary / therapy. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 19205699.001).
  • [ISSN] 1619-7089
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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66. Rahbari R, Sansano IG, Elaraj DM, Duh QY, Clark OH, Kebebew E: Prior head and neck radiation exposure is not a contraindication to minimally invasive parathyroidectomy. J Am Coll Surg; 2010 Jun;210(6):942-8
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  • [Title] Prior head and neck radiation exposure is not a contraindication to minimally invasive parathyroidectomy.
  • In patients with a history of head and neck irradiation, due to the increased risk of multigland disease and risk of concurrent thyroid cancer, minimally invasive parathyroidectomy is considered by some to be a contraindication.
  • We postulated that previous history of head and neck irradiation should not be a contraindication for minimally invasive parathyroidectomy and tested this hypothesis in a prospective cohort of patients undergoing parathyroidectomy for primary hyperparathyroidism.
  • RESULTS: Fifty-two (12.6%) patients had a history of head and neck irradiation and 360 (87.4%) had no exposure to radiation.
  • There was no significant difference in concurrent benign thyroid neoplasm, thyroid cancer, and type of parathyroid disease (single vs multigland) in the 2 groups.
  • CONCLUSIONS: Head and neck irradiation should not be a contraindication for minimally invasive parathyroidectomy in patients with primary hyperparathyroidism in the setting of preoperative localization studies showing single-gland disease and no concurrent thyroid neoplasm.
  • Furthermore, history of head and neck irradiation is associated with a later age of presentation for parathyroidectomy.
  • [MeSH-major] Head and Neck Neoplasms / radiotherapy. Hyperparathyroidism, Primary / surgery. Parathyroidectomy. Radiotherapy. Thyroid Neoplasms / radiotherapy

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  • [Copyright] Published by Elsevier Inc.
  • (PMID = 20510803.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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67. Shimada K, Sakamoto Y, Esaki M, Kosuge T, Hiraoka N: Role of medial pancreatectomy in the management of intraductal papillary mucinous neoplasms and islet cell tumors of the pancreatic neck and body. Dig Surg; 2008;25(1):46-51
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  • [Title] Role of medial pancreatectomy in the management of intraductal papillary mucinous neoplasms and islet cell tumors of the pancreatic neck and body.
  • BACKGROUND/AIM: Medial pancreatectomy has been applied as a safe and effective alternative in benign diseases located in the pancreatic neck or body.
  • Three patients with islet cell tumor and 1 patient with solid pseudopapillary tumor had no malignant disease.
  • CONCLUSIONS: A medial pancreatectomy is a safe and effective alternative for the treatment of intraductal papillary mucinous neoplasm, islet cell tumor, or solid pseudopapillary tumor located in the neck or body of the pancreas.

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  • (PMID = 18292661.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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68. Rosário PW, Tavares Júnior WC, Biscolla RP, Purisch S, Maciel RM: [Usefulness of neck ultrasonography in the follow-up of patients with differentiated thyroid cancer]. Arq Bras Endocrinol Metabol; 2007 Jun;51(4):593-600
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  • [Title] [Usefulness of neck ultrasonography in the follow-up of patients with differentiated thyroid cancer].
  • Neck ultrasonography (US) is recommended for the assessment of all patients with thyroid carcinoma after initial therapy, since even low-risk patients with undetectable stimulated thyroglobulin (Tg) may present cervical metastases.
  • In the absence of these characteristics, a round shape and the absence of an echogenic hilum are "suspicious" findings, whereas elongated lymph nodes with a visible echogenic hilum are considered benign.
  • [MeSH-major] Carcinoma, Papillary / ultrasonography. Lymph Nodes / ultrasonography. Neck / ultrasonography. Thyroid Neoplasms / ultrasonography
  • [MeSH-minor] Follow-Up Studies. Humans. Lymphatic Metastasis. Neoplasm Staging. Sensitivity and Specificity

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  • (PMID = 17684621.001).
  • [ISSN] 0004-2730
  • [Journal-full-title] Arquivos brasileiros de endocrinologia e metabologia
  • [ISO-abbreviation] Arq Bras Endocrinol Metabol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 39
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69. Bei R, Masuelli L, Trono P, Orvietani PL, Losito S, Marzocchella L, Vitolo D, Albonici L, Mrozek MA, Di Gennaro E, Lista F, Faggioni G, Ionna F, Binaglia L, Manzari V, Budillon A, Modesti A: The ribosomal P0 protein induces a spontaneous immune response in patients with head and neck advanced stage carcinoma that is not dependent on its overexpression in carcinomas. Int J Oncol; 2007 Dec;31(6):1301-8
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  • [Title] The ribosomal P0 protein induces a spontaneous immune response in patients with head and neck advanced stage carcinoma that is not dependent on its overexpression in carcinomas.
  • In this report we provide evidence for the in vivo immunogenicity of the P0 protein in head and neck cancer patients as well as overexpression by immunohistochemistry of the C-22 P0 epitope in invasive carcinomas (55/57).
  • Overexpression of this epitope was also significantly associated with a number of pathological lesions arising in the head and neck stratified epithelium including acanthosis (8/8), benign tumors (11/11), dysplasia (23/25) and in situ carcinomas (9/9).
  • Intermediate cell layer restricted epitope overexpression was observed in well differentiated carcinomas, while undifferentiated tumors showed overexpression throughout the cell layers.
  • Evidence for immunity to the P0 protein, as well as overexpression in patients with head and neck carcinoma may be relevant for monitoring cancer progression, in planning immunotherapeutic strategies, and contribute to the understanding of immuno-biological behaviour of head and neck carcinomas.
  • [MeSH-major] Carcinoma, Squamous Cell / immunology. Head and Neck Neoplasms / immunology. Ribosomal Proteins / immunology
  • [MeSH-minor] Amino Acid Sequence. Antibodies / blood. Antibodies, Monoclonal / immunology. Cell Line, Tumor. Epitopes. Humans. Molecular Sequence Data. Neoplasm Staging

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  • (PMID = 17982655.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antibodies, Monoclonal; 0 / Epitopes; 0 / Ribosomal Proteins; 0 / ribosomal protein P0
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70. Tatomirovic Z, Skuletic V, Bokun R, Trimcev J, Radic O, Cerovic S, Strbac M, Zolotarevski L, Tukic Lj, Stamatovic D, Tarabar O: Fine needle aspiration cytology in the diagnosis of head and neck masses: accuracy and diagnostic problems. J BUON; 2009 Oct-Dec;14(4):653-9
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  • [Title] Fine needle aspiration cytology in the diagnosis of head and neck masses: accuracy and diagnostic problems.
  • PURPOSE: Fine needle aspiration (FNA) cytology is an established technique associated with minimal complications compared with more invasive techniques such as wide core needle biopsy or open biopsy, and as such, very suitable for obtaining material in the delicate region of head and neck (H&N).
  • The overall accuracy rate of FNA cytology, whether malignant or benign, was 91.89%, while the diagnostic accuracy for the exact type of tumor was 87.16%.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Lymphoma / diagnosis. Pseudolymphoma / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Biopsy, Fine-Needle. Biopsy, Needle. Carcinoma, Small Cell / diagnosis. Carcinoma, Small Cell / secondary. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / secondary. Cytological Techniques. Diagnosis, Differential. Diagnostic Errors. Humans. Neoplasm Staging. Prognosis. Sensitivity and Specificity

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  • (PMID = 20148458.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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71. Boi F, Maurelli I, Pinna G, Atzeni F, Piga M, Lai ML, Mariotti S: Calcitonin measurement in wash-out fluid from fine needle aspiration of neck masses in patients with primary and metastatic medullary thyroid carcinoma. J Clin Endocrinol Metab; 2007 Jun;92(6):2115-8
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  • [Title] Calcitonin measurement in wash-out fluid from fine needle aspiration of neck masses in patients with primary and metastatic medullary thyroid carcinoma.
  • OBJECTIVE: The aim of the study was to evaluate the usefulness of calcitonin (CT) assay in fine-needle aspiration biopsy (FNAB) wash-out fluid alone or combined with cytology in the presurgical study of medullary thyroid carcinoma (MTC) patients with thyroid nodules (TNs) and of suspicious neck MTC recurrences/metastases.
  • SUBJECTS AND METHODS: A total of 36 ultrasound-guided FNABs were performed in neck masses from 23 patients with borderline or high basal and pentagastrin-stimulated serum CT.
  • Cytology and CT-FNAB were performed on a total of 18 TNs and three neck lymph nodes (LNs) from 12 patients examined before thyroidectomy, and on six suspicious local recurrences (LRs) and nine LNs from nine totally thyroidectomized MTC patients.
  • Of the 15 negative CT-FNAB suspicious masses (eight TNs, six LNs, and one LR), five displayed a benign lesion at histology.
  • The remaining 10 cases, all with benign cytology, were not operated on, and no evidence of MTC was detected at follow-up.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Calcitonin / metabolism. Thyroid Neoplasms / metabolism. Thyroid Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Body Fluids / metabolism. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Thyroid Nodule / metabolism. Thyroid Nodule / pathology

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  • (PMID = 17405835.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 9007-12-9 / Calcitonin
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72. Withrow KP, Newman JR, Skipper JB, Gleysteen JP, Magnuson JS, Zinn K, Rosenthal EL: Assessment of bevacizumab conjugated to Cy5.5 for detection of head and neck cancer xenografts. Technol Cancer Res Treat; 2008 Feb;7(1):61-6
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  • [Title] Assessment of bevacizumab conjugated to Cy5.5 for detection of head and neck cancer xenografts.
  • To determine the efficacy of fluorescently labeled anti-vascular endothelial growth factor (VEGF) antibody to be used as a cancer specific optical contrast agent to guide surgical resections, we evaluated the sensitivity and specificity of this agent to detect microscopic residual disease in a preclinical model of head and neck squamous cell carcinoma (HNSCC).
  • Using a flank murine model, mice were xenografted with SCC-1 tumor cells and injected with anti-VEGF antibody (bevacizumab) conjugated to an optically active fluorophore (Cy5.5).
  • Tumors underwent sub-total resections and were assessed for the presence of residual disease by fluorescent stereomicroscopy.
  • Samples taken from a non-fluorescing tumor bed (n=15) were found to be histologically benign in 11 of 15.
  • This data supports previous data presented by this group and supports further investigation of fluorescently labeled anti-tumor antibodies to detect disease in the surgical setting.
  • [MeSH-major] Antibodies, Monoclonal. Carbocyanines. Head and Neck Neoplasms / diagnosis. Vascular Endothelial Growth Factor A / antagonists & inhibitors
  • [MeSH-minor] Animals. Antibodies, Monoclonal, Humanized. Bevacizumab. Humans. Male. Mice. Mice, SCID. Neoplasm Transplantation. Transplantation, Heterologous

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  • (PMID = 18198926.001).
  • [ISSN] 1533-0346
  • [Journal-full-title] Technology in cancer research & treatment
  • [ISO-abbreviation] Technol. Cancer Res. Treat.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA13148
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / CY5.5 cyanine dye; 0 / Carbocyanines; 0 / Vascular Endothelial Growth Factor A; 2S9ZZM9Q9V / Bevacizumab
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73. Sandison A: Common head and neck cases in our consultation referrals: diagnostic dilemmas in inverted papilloma. Head Neck Pathol; 2009 Sep;3(3):260-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Common head and neck cases in our consultation referrals: diagnostic dilemmas in inverted papilloma.
  • The most common diagnostic dilemma for pathologists referring cases for second opinion is the recognition of low grade malignancy versus benign inverted papilloma at presentation and in lesions which recur.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Papilloma, Inverted / pathology
  • [MeSH-minor] Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Humans. Neoplasm Recurrence, Local / pathology. Neoplasms, Multiple Primary / pathology. Neoplasms, Second Primary / pathology

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  • (PMID = 20596982.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
  • [Other-IDs] NLM/ PMC2811634
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74. Fritz MA, Sade B, Bauer TW, Wood BG, Lee JH: Benign fibrous histiocytoma of the pterygopalatine fossa with intracranial extension. Acta Neurochir (Wien); 2006 Jan;148(1):73-6; discussion 76

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  • [Title] Benign fibrous histiocytoma of the pterygopalatine fossa with intracranial extension.
  • Despite the histologic absence of nuclear pleomorphism, the tumor rapidly recurred after complete surgical resection.
  • The aggressive nature of our patient's tumor confirms previous observations that an aggressive radiographic appearance has prognostic value when dealing with skeletal and soft tissue tumors.
  • The benefit of multimodal therapy has not been established in these rare head and neck lesions.
  • [MeSH-major] Brain / pathology. Histiocytoma, Benign Fibrous / pathology. Neoplasm Recurrence, Local / pathology. Palate, Hard. Skull Base Neoplasms / pathology
  • [MeSH-minor] Fatal Outcome. Humans. Male. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 16200478.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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75. Kross KW, Heimdal JH, Olsnes C, Olofsson J, Aarstad HJ: Head and neck squamous cell carcinoma spheroid- and monocyte spheroid-stimulated IL-6 and monocyte chemotactic protein-1 secretion are related to TNM stage, inflammatory state and tumor macrophage density. Acta Otolaryngol; 2005 Oct;125(10):1097-104
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  • [Title] Head and neck squamous cell carcinoma spheroid- and monocyte spheroid-stimulated IL-6 and monocyte chemotactic protein-1 secretion are related to TNM stage, inflammatory state and tumor macrophage density.
  • Monocyte fragment (F)-spheroid-stimulated and F-spheroid IL-6 and monocyte chemotactic protein (MCP)-1 secretion are related to inflammatory state, macrophage density and the TNM stage of patients with head and neck squamous cell carcinoma (HNSCC).
  • In series II (n=17) the TNM stage, donor inflammatory state, macrophage density and the secretion of F-spheroid- and monocyte F-spheroid-stimulated IL-6, MCP-1 and tumor necrosis factor (TNF)-alpha were determined.
  • Malignant (M) F-spheroids secreted more MCP-1 than benign (B) F-spheroids.
  • [MeSH-major] Carcinoma, Squamous Cell / secretion. Chemokine CCL2 / secretion. Head and Neck Neoplasms / secretion. Interleukin-6 / secretion. Monocytes / secretion. Spheroids, Cellular / secretion
  • [MeSH-minor] Blood Sedimentation. Cell Count. Coculture Techniques. Humans. Macrophages. Neoplasm Staging. Tumor Cells, Cultured. Tumor Necrosis Factor-alpha / secretion


76. Ma C, Quesnelle KM, Sparano A, Rao S, Park MS, Cohen MA, Wang Y, Samanta M, Kumar MS, Aziz MU, Naylor TL, Weber BL, Fakharzadeh SS, Weinstein GS, Vachani A, Feldman MD, Brose MS: Characterization CSMD1 in a large set of primary lung, head and neck, breast and skin cancer tissues. Cancer Biol Ther; 2009 May;8(10):907-16
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  • [Title] Characterization CSMD1 in a large set of primary lung, head and neck, breast and skin cancer tissues.
  • The Cub and Sushi Multiple Domains-1 (CSMD1) is a tumor suppressor gene on 8p23.2, where allelic loss is both frequent and associated with poor prognosis in head and neck squamous cell carcinoma (HNSCC).
  • To understand the extent of CSMD1 aberrations in vivo, we characterized 184 primary tumors from the head and neck, lung, breast and skin for gene copy number and analyzed expression in our HNSCCs and lung squamous cell carcinomas (SCCs).
  • CSMD1 expression was decreased in tumors compared to adjacent benign tissue (65%, 13/20) and was likely due to gene loss in 45% of cases (9/20).
  • [MeSH-major] Breast Neoplasms / genetics. Head and Neck Neoplasms / genetics. Lung Neoplasms / genetics. Membrane Proteins / genetics. Skin Neoplasms / genetics
  • [MeSH-minor] Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / pathology. Case-Control Studies. Chromosome Deletion. Comparative Genomic Hybridization. DNA, Neoplasm / analysis. Female. Gene Dosage. Gene Expression. Humans. Loss of Heterozygosity. Mouth Neoplasms / genetics. RNA, Messenger / genetics. RNA, Messenger / metabolism


77. Wu J, Crimmins JT, Monk KR, Williams JP, Fitzgerald ME, Tedesco S, Ratner N: Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign world health organization grade I neurofibroma. Am J Pathol; 2006 May;168(5):1686-96
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  • [Title] Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign world health organization grade I neurofibroma.
  • Benign peripheral nerve tumors called neurofibromas are a major source of morbidity for patients with neurofibromatosis type 1.

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  • (PMID = 16651634.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS028840; United States / NCI NIH HHS / CA / T32 CA059268; United States / NINDS NIH HHS / NS / NS28840; United States / NCI NIH HHS / CA / T32-CA-59268
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 0 / Chemotactic Factors; 0 / Fibroblast Growth Factor 9; 0 / Neurofibromin 1; 0 / Oncogene Proteins v-fos; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 3.1.4.- / 2',3'-Cyclic-Nucleotide Phosphodiesterases; PQX0D8J21J / Cetuximab
  • [Other-IDs] NLM/ PMC1606591
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78. Bisdas S, Baghi M, Huebner F, Mueller C, Knecht R, Vorbuchner M, Ruff J, Gstoettner W, Vogl TJ: In vivo proton MR spectroscopy of primary tumours, nodal and recurrent disease of the extracranial head and neck. Eur Radiol; 2007 Jan;17(1):251-7
MedlinePlus Health Information. consumer health - Head and Neck Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] In vivo proton MR spectroscopy of primary tumours, nodal and recurrent disease of the extracranial head and neck.
  • Benign and malignant neoplasms as well as metastatic lymph nodes of 39 patients were examined using localized single voxel magnetic resonance spectroscopy (MRS) [repetition time (TR) 1500, echo time (TE) 135) at 1.5 T.
  • The Cho/Cr ratios in all malignant neoplasms (mean: 5.2, range: 1.7-17.8) were significantly elevated relative to those in the normal muscle structures (mean: 0.9, range: 0.2-1.4), while those in the benign neoplasms were elevated (mean: 24.4, range: 1.4-59.7) with respect to those in the malignant ones.
  • The average Cho/Cr ratio in the metastatic lymph nodes was significantly higher (mean: 4.8, range: 3.3-5.6) than that for benign lymphoid hyperplasia (mean: 2.2, range: 1.0-3.0).
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Magnetic Resonance Spectroscopy. Neoplasm Recurrence, Local / diagnosis

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  • [Cites] Proc Natl Acad Sci U S A. 1989 Jun;86(12):4402-6 [2734292.001]
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  • (PMID = 16703309.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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79. Franzmann EJ, Reategui EP, Pedroso F, Pernas FG, Karakullukcu BM, Carraway KL, Hamilton K, Singal R, Goodwin WJ: Soluble CD44 is a potential marker for the early detection of head and neck cancer. Cancer Epidemiol Biomarkers Prev; 2007 Jul;16(7):1348-55
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Soluble CD44 is a potential marker for the early detection of head and neck cancer.
  • INTRODUCTION: Head and neck squamous cell carcinoma (HNSCC) is a devastating and deadly disease, largely because it is diagnosed in late stage.
  • In this study, we evaluate soluble CD44 (solCD44) as an early detection tool for HNSCC by determining whether it reliably distinguishes HNSCC from benign disease of the upper aerodigestive tract.
  • METHODS: We carried out the solCD44 ELISA on oral rinses from 102 patients with HNSCC and 69 control patients with benign diseases of upper aerodigestive tract to determine the sensitivity and specificity of the test for differentiating HNSCC from benign disease.
  • Furthermore, we did a pilot study using methylation-specific PCR primers on oral rinses from 11 HNSCC patients with low solCD44 levels and 10 benign disease controls.
  • RESULTS: Mean salivary solCD44 levels were 24.4 +/- 32.0 ng/mL for HNSCC patients (range, 0.99-201 ng/mL) and 9.9 +/- 16.1 ng/mL (range, 0.73-124 ng/mL) for the patients with benign disease (P < 0.0001).
  • CONCLUSIONS: SolCD44 is elevated in the majority of HNSCC and distinguishes cancer from benign disease with high specificity.
  • [MeSH-major] Antigens, CD44 / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / metabolism. Head and Neck Neoplasms / metabolism
  • [MeSH-minor] Case-Control Studies. DNA Methylation. Enzyme-Linked Immunosorbent Assay. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Pilot Projects. Prognosis. Saliva / metabolism. Sensitivity and Specificity

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  • (PMID = 17627000.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA107828
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD44; 0 / Biomarkers, Tumor; 0 / CD44 protein, human
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80. Chiofalo MG, Longo F, Marone U, Franco R, Petrillo A, Pezzullo L: Cervical vagal schwannoma. A case report. Acta Otorhinolaryngol Ital; 2009 Feb;29(1):33-5
Genetic Alliance. consumer health - Schwannoma.

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  • Schwannoma originating from the cervical vagus nerve is an extremely rare neoplasm.
  • Vagal nerve schwannoma usually occurs between the third and fifth decades of life, it does not show sex predilection both sexes being equally affected and it most often presents as a painless, slow-growing, lateral neck mass.
  • These tumours, in fact, are almost always benign and a conservative surgical approach is emphasized by most of the Authors.

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  • [Cites] J Laryngol Otol. 2000 Feb;114(2):119-24 [10748827.001]
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  • (PMID = 19609380.001).
  • [ISSN] 1827-675X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2689565
  • [Keywords] NOTNLM ; Benign tumours / Magnetic Resonance imaging / Schwannoma / Vagus nerve
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81. Durden FL Jr, Moore CE, Muller S: Verrucous carcinoma of the paranasal sinuses: a case report. Ear Nose Throat J; 2010 Jul;89(7):E21-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Verrucous carcinoma is a low-grade variant of squamous cell carcinoma reported to occur in all anatomic sites in the head and neck region, most commonly the oral cavity.
  • The tumor grows locally invasive but is histologically benign and metastasizes rarely.
  • [MeSH-minor] Biopsy. Endoscopy. Humans. Male. Middle Aged. Nasal Cavity / pathology. Nasal Cavity / radiation effects. Nasal Cavity / surgery. Neoplasm Invasiveness. Neoplasm Staging. Orbital Neoplasms / pathology. Orbital Neoplasms / radiotherapy. Orbital Neoplasms / surgery. Skull / pathology. Skull / radiation effects. Skull / surgery. Skull Neoplasms / pathology. Skull Neoplasms / radiotherapy. Skull Neoplasms / surgery

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  • (PMID = 20628974.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. Pino Rivero V, Trinidad Ruiz G, Pardo Romero G, González Palomino A, Pantoja Hernández CG, Marqués Rebollo L, Blasco Heulva A: [Cervical giant lipoma. Clinical report of a case and differential diagnosis]. An Otorrinolaringol Ibero Am; 2005;32(4):345-51
MedlinePlus Health Information. consumer health - Head and Neck Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lipomas represent one of the most common benign tumours in any location.
  • However, the giant variants are relatively uncommon and cause diagnostic problems with other neoplasm benign and malign.
  • We are reporting the case of a 69 years-old male who presented a neck mass which size was more than 12 cm of diameter and corresponded to lipoma after its removal and anatomopathologic exam.
  • [MeSH-major] Head and Neck Neoplasms / radiography. Lipoma / radiography

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  • (PMID = 16156364.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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83. Derin AT, Güney K, Turhan M, Erdoğan A, Ağirdir BV: Giant cervical lipoma invading carotid artery: a case report. Kulak Burun Bogaz Ihtis Derg; 2009 Jan-Feb;19(1):28-31
MedlinePlus Health Information. consumer health - Head and Neck Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lipomas are one of the most frequently encountered benign tumors in any location.
  • There is limited information about head and neck lipomas in the litetature and most data is in the form of case reports.
  • [MeSH-major] Carotid Artery, Common / pathology. Head and Neck Neoplasms / pathology. Lipoma / pathology
  • [MeSH-minor] Blood Vessel Prosthesis. Humans. Male. Middle Aged. Neoplasm Invasiveness. Treatment Outcome

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  • (PMID = 19793044.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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84. Gondivkar SM, Indurkar A, Degwekar S, Bhowate R: Primary oral malignant melanoma--a case report and review of the literature. Quintessence Int; 2009 Jan;40(1):41-6
MedlinePlus Health Information. consumer health - Melanoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Malignant melanoma is a neoplasm of melanocytic origin that arises from a benign melanocytic lesion or de novo from melanocytes within otherwise normal mucosa or skin.
  • Melanoma arising from the mucosal surfaces of the head and neck is a very rare disease and is considered among the most deadly of all human neoplasms.
  • [MeSH-minor] Adult. Humans. Male. Maxilla / surgery. Neoplasm Staging

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  • (PMID = 19159022.001).
  • [ISSN] 1936-7163
  • [Journal-full-title] Quintessence international (Berlin, Germany : 1985)
  • [ISO-abbreviation] Quintessence Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 19
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85. Pant I, Joshi SC, Kaur G, Kumar G: Pilomatricoma as a diagnostic pitfall in clinical practice: report of two cases and review of literature. Indian J Dermatol; 2010 Oct;55(4):390-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pilomatricoma (PMC) is a relatively uncommon benign skin neoplasm arising from the skin adnexa.
  • Since the first description of PMC in 1880, there has been a gradual increase in understanding of the morphologic features and clinical presentation of this tumor.
  • The purpose of this article is to create awareness among clinicians on the possibility of pilomatricoma as a cause of solitary skin nodules, especially those on the head, neck or upper extremities.

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  • [Cites] Int J Pediatr Otorhinolaryngol. 2001 Feb;57(2):123-8 [11165649.001]
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  • (PMID = 21430899.001).
  • [ISSN] 1998-3611
  • [Journal-full-title] Indian journal of dermatology
  • [ISO-abbreviation] Indian J Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3051306
  • [Keywords] NOTNLM ; Pilomatricoma / dermatopathology / skin nodules
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86. Cardoso JC, Reis JP, Figueiredo P, Tellechea O: Infundibulomatosis: a case report with immunohistochemical study and literature review. Dermatol Online J; 2010;16(1):14
MedlinePlus Health Information. consumer health - Head and Neck Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tumor of the follicular infundibulum was first described in 1961 by Mehregan and Butler in a patient presenting with multiple papules.
  • It is more frequent, however, as an isolated lesion affecting mainly the face, neck, and upper trunk.
  • A well defined network of elastic fibers surrounding the tumor is usually present using the appropriate staining and this finding is specific because it is not found in other benign follicular tumors.
  • The authors report the case of a 30-year-old female patient with a 5-year history of multiple small discrete hypopigmented macules and papules, scattered over the submental and submaxillary regions and anterior neck.
  • Histopathological findings were consistent with the diagnosis of tumor of the follicular infundibulum.
  • [MeSH-major] Acanthoma / pathology. Hair Follicle / pathology. Head and Neck Neoplasms / pathology. Neoplasms, Multiple Primary / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor. Diagnosis, Differential. Female. Humans. Hypopigmentation / etiology. Keratinocytes / pathology. Neoplasm Proteins / analysis. Periodic Acid-Schiff Reaction

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  • (PMID = 20137756.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
  • [Number-of-references] 10
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87. Loyo M, Pai SI, Netto GJ, Tunkel DE: Aggressive recurrent respiratory papillomatosis in a neonate. Int J Pediatr Otorhinolaryngol; 2008 Jun;72(6):917-20
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Recurrent respiratory papillomatosis is the most common benign laryngeal neoplasm in children.
  • [MeSH-major] Laryngeal Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Papilloma / pathology

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  • (PMID = 18423627.001).
  • [ISSN] 0165-5876
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 0 / Organophosphonates; 8J337D1HZY / Cytosine; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; JIL713Q00N / cidofovir; PQX0D8J21J / Cetuximab
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88. Kung B, Aftab S, Wood M, Rosen D: Malignant melanoma metastatic to the thyroid gland: a case report and review of the literature. Ear Nose Throat J; 2009 Jan;88(1):E7
MedlinePlus Health Information. consumer health - Thyroid Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We describe the case of a 68-year-old man who presented with a neck mass in the posterior triangle.
  • He underwent a left modified radical neck dissection, and the mass was discovered to be a positive lymph node.
  • Patients who present with a thyroid nodule and who have a history of malignancy present a diagnostic dilemma: Is the nodule benign, a new primary, or a distant metastasis?
  • [MeSH-major] Melanoma / secondary. Neoplasm Invasiveness / pathology. Thyroid Neoplasms / secondary. Thyroid Nodule / pathology
  • [MeSH-minor] Aged. Biopsy, Fine-Needle. Follow-Up Studies. Humans. Immunohistochemistry. Lymph Nodes / pathology. Male. Neck Dissection. Neoplasm Staging. Risk Assessment. Thyroidectomy / methods. Treatment Outcome

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  • (PMID = 19172560.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 14
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89. Tasca RA, Clarke RW: Recurrent respiratory papillomatosis. Arch Dis Child; 2006 Aug;91(8):689-91
Genetic Alliance. consumer health - Recurrent respiratory papillomatosis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Recurrent respiratory papillomatosis (RRP) is a benign, often multi-focal neoplasm.
  • [MeSH-major] Neoplasm Recurrence, Local. Papilloma. Papillomavirus Infections. Respiratory Tract Neoplasms

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  • (PMID = 16861486.001).
  • [ISSN] 1468-2044
  • [Journal-full-title] Archives of disease in childhood
  • [ISO-abbreviation] Arch. Dis. Child.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antiviral Agents
  • [Number-of-references] 31
  • [Other-IDs] NLM/ PMC2083023
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90. Kawata R, Yoshimura K, Lee K, Araki M, Takenaka H, Tsuji M: Basal cell adenoma of the parotid gland: a clinicopathological study of nine cases--basal cell adenoma versus pleomorphic adenoma and Warthin's tumor. Eur Arch Otorhinolaryngol; 2010 May;267(5):779-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basal cell adenoma of the parotid gland: a clinicopathological study of nine cases--basal cell adenoma versus pleomorphic adenoma and Warthin's tumor.
  • The aim of this study is to investigate the clinical and pathological characteristics of basal cell adenoma (BCA) and to compare the diagnosis/treatment of BCA with those of Warthin's tumor (WT) and pleomorphic adenoma (PA).
  • Among 192 patients with benign tumors of the parotid gland who underwent surgery, 9 had BCA.
  • All of these tumors showed a benign pattern on computed tomography and magnetic resonance imaging.
  • Considering the gender difference, tumor site, and age, it is necessary to differentiate BCA from PA rather than from WT.
  • BCA is the third most common of the benign parotid tumors, following WT and PA, although its incidence is low.
  • When PA and WT are ruled out by FNAB after a tentative diagnosis of benign tumor has been based on imaging findings, BCA should be considered.
  • [MeSH-minor] Adult. Aged. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Time Factors

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  • [Cites] Diagn Cytopathol. 2007 Feb;35(2):85-90 [17230571.001]
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  • (PMID = 19908055.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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91. Manucha V, Ioffe OB: Metastasizing pleomorphic adenoma of the salivary gland. Arch Pathol Lab Med; 2008 Sep;132(9):1445-7
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  • Metastasizing pleomorphic adenoma of salivary glands is a group of rare tumors that are histologically identical to benign mixed tumors and that inexplicably metastasize.
  • The most common site for metastasis is bone, followed by the head and neck and lung.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Neoplasm Invasiveness / pathology. Salivary Gland Neoplasms / pathology. Salivary Gland Neoplasms / secondary
  • [MeSH-minor] Humans. Neoplasm Recurrence, Local / pathology

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  • (PMID = 18788859.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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92. Ponce-Camacho MA, Diaz de Leon-Medina R, Miranda-Maldonado I, Garza-Guajardo R, Hernandez-Salazar J, Barboza-Quintana O: A 5-year-old girl with a congenital ganglioneuroma diagnosed by fine needle aspiration biopsy: a case report. Cytojournal; 2008;5:5

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  • INTRODUCTION: Ganglioneuroma is a rare, benign, neuroblastic tumor arising mainly from the central or peripheral autonomic nervous system, especially the sympathetic system.
  • The most affected anatomical sites are the posterior mediastinum, retroperitoneum, adrenal gland and head and neck soft tissue.
  • CONCLUSION: Congenital ganglioneuroma of the cervical region is an uncommon soft tissue benign neoplasm of neuroblastic origin, and it should be considered in the differential diagnosis of head and neck pediatric soft tissue tumors.
  • Fine needle aspiration biopsy technique is a reliable method that can be used with confidence when dealing with pediatric soft tissue tumors.

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  • (PMID = 18373875.001).
  • [ISSN] 1742-6413
  • [Journal-full-title] CytoJournal
  • [ISO-abbreviation] Cytojournal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2359765
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93. Ellies M, Schaffranietz F, Arglebe C, Laskawi R: Tumors of the salivary glands in childhood and adolescence. J Oral Maxillofac Surg; 2006 Jul;64(7):1049-58
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumors of the salivary glands in childhood and adolescence.
  • PURPOSE: We report on 52 juvenile and adolescent patients with benign and malignant tumors of the salivary glands.
  • RESULTS: Benign tumors had their highest incidence in puberty and postpuberty.
  • Forty patients (20 girls and 20 boys; 77%) had benign growths and 12 patients (9 girls and 3 boys; 23%) suffered from malignant neoplasms.
  • After surgery for benign tumors we saw no postoperative recurrences in long-term follow-up.
  • In the group of malignant tumors, 8 patients (66.7%) survived their disease in the long-term follow-up.
  • This is particularly true for the malignant parotid tumors that are more frequent in juvenile patients, a fact that has to be considered in diagnosis and therapy.
  • [MeSH-major] Adenoma, Pleomorphic / therapy. Carcinoma / therapy. Neoplasm Recurrence, Local / therapy. Salivary Gland Neoplasms / therapy

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  • (PMID = 16781337.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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94. Lai JC, Tsai YL: Schwannoma of the auricle. B-ENT; 2010;6(4):281-3
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  • RESULTS: Schwannoma is a benign, encapsulated, slow-growing neoplasm.
  • Approximately 25-45% of all schwannomas occur in the head and neck, whereas schwannomas of the external ear are extremely uncommon, with only nine cases reported in the English literature since the first report in 1977.
  • Schwannoma should be considered in the evaluation of any tumour of the auricle.

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  • (PMID = 21302691.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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95. Hornick JL, Fletcher CD: Cellular neurothekeoma: detailed characterization in a series of 133 cases. Am J Surg Pathol; 2007 Mar;31(3):329-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cellular neurothekeomas are distinctive benign cutaneous tumors of uncertain histogenesis.
  • Mean tumor size was 1.1 cm (range: 0.3 to 6 cm; 90% <2 cm).
  • The tumors arose most often on the upper limb (35%) or head and neck (33%).
  • Fifty-two percent of the tumors were limited to the dermis, and 48% also involved superficial subcutaneous tissue.
  • In 30% of cases, neurothekeoma was suggested by the referring pathologist; the most common other diagnoses offered were plexiform fibrohistiocytic tumor, benign fibrous histiocytoma, and a low-grade sarcoma.
  • Nearly all tumors had a lobulated or micronodular architecture and were composed of nests and bundles of epithelioid to spindled cells with palely eosinophilic cytoplasm, often separated by dense hyaline collagen; 17 (13%) showed focally sheetlike areas, and 5 (4%) were notably plexiform.
  • Myxoid stroma was observed in 38 (29%) tumors; 11 (8%) were predominantly myxoid.
  • Most tumors showed mild cytologic atypia in the form of nuclear variability and small nucleoli; 33 (25%) contained notably pleomorphic cells.
  • All tumors were reactive for NKI-C3, 110/123 (89%) expressed neuron-specific enolase, 73/127 (57%) showed at least focal staining for smooth muscle actin, and only 1 was focally desmin positive.
  • All tumors were negative for S-100 protein.
  • Ten tumors recurred locally (7 situated on the face), after a mean of 18 months; tumor had been marginally excised or had involved excision margins in all cases with available information.
  • Cellular neurothekeomas have a predilection for the upper limbs and head and neck of pediatric and young adult females and rarely recur following incomplete excision.
  • There is no good evidence that these lesions show nerve sheath differentiation and the nomenclature will likely change when the tumor cell lineage is better defined.
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Child. Child, Preschool. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Immunohistochemistry. Infant. Male. Middle Aged. Mitosis. Neoplasm Recurrence, Local. Sarcoma / diagnosis

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  • (PMID = 17325474.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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96. Seyhan T, Borman H, Bal N: Malignant eccrine spiradenoma of the scalp. J Craniofac Surg; 2008 Nov;19(6):1608-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Malignant eccrine spiradenoma is a rare neoplasm generally arising from long-standing benign eccrine spiradenomas; it is rarely seen on the scalp.
  • A 27-year-old woman with a malignant eccrine spiradenoma of the scalp, which had occurred 8 months after the inadequate excision of a benign eccrine spiradenoma, was treated at our hospital.
  • The tumor with its large subcutaneous extension and the outer table of the cranium were removed.
  • At 24 months' follow-up, there has been no tumor recurrence.
  • We report a case of a malignant eccrine spiradenoma of the scalp with cranial involvement that arose from an inadequately removed, long-standing, benign eccrine spiradenoma in a young patient.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Head and Neck Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis. Scalp / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Alopecia / diagnosis. Female. Follow-Up Studies. Humans. Neoplasm Invasiveness. Sentinel Lymph Node Biopsy. Skin Transplantation

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  • (PMID = 19098562.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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97. Zhi K, Ren W, Zhou H, Wen Y, Zhang Y: Management of parapharyngeal-space tumors. J Oral Maxillofac Surg; 2009 Jun;67(6):1239-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of parapharyngeal-space tumors.
  • PURPOSE: This study evaluated parapharyngeal-space (PPS) tumors in regard to clinical pathological features, preoperative assessment, surgical approaches, perioperative complications, and patterns of recurrence.
  • PATIENTS AND METHODS: We performed a retrospective review of patients with PPS tumors referred to the stomatological hospitals of Sichuan University and Xi'an Jiaotong University between 1990 and 2004.
  • RESULTS: Beginning in 1990 and ending in 2004, 162 patients with PPS tumors were evaluated in our unit.
  • The main presenting symptom was neck swelling.
  • The most common class of lesion was salivary-gland neoplasm, accounting for 74 cases (45.68%).
  • The next most common group of tumors was neurogenic, representing 68 cases (41.98%).
  • CONCLUSIONS: Surgery is the mainstay treatment for PPS tumors.
  • Surgical approaches were dictated by size of the tumor, its location, its relationship to the great vessels, and suspicion of malignancy.
  • The most common approach was transcervical-transparotid for benign tumors.
  • [MeSH-major] Head and Neck Neoplasms / surgery. Pharyngeal Neoplasms / surgery
  • [MeSH-minor] Adenoma, Pleomorphic / surgery. Adult. Biopsy, Fine-Needle. Carcinoma / secondary. Carcinoma / surgery. Chemotherapy, Adjuvant. Cranial Nerve Diseases / etiology. Female. Follow-Up Studies. Humans. Magnetic Resonance Angiography. Magnetic Resonance Imaging. Male. Neck Muscles / surgery. Neoplasm Recurrence, Local / pathology. Parotid Gland / surgery. Postoperative Complications. Radiotherapy, Adjuvant. Retrospective Studies. Salivary Gland Neoplasms / surgery. Tomography, X-Ray Computed

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  • [CommentIn] J Oral Maxillofac Surg. 2010 May;68(5):1209-11; author reply 1212 [20403530.001]
  • (PMID = 19446210.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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98. Folk GS, Williams SB, Foss RB, Fanburg-Smith JC: Oral and maxillofacial sclerosing epithelioid fibrosarcoma: report of five cases. Head Neck Pathol; 2007 Sep;1(1):13-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Approximately 59 cases of SEF have been reported, with only 12 previously described in head and neck locations.
  • The OMF Pathology Department Registry was searched for cases coded from 1990 to the present as "SEF," "fibrosarcoma not otherwise specified" or "neoplasm of uncertain histiogenesis."
  • Tumor location included the infra-temporal fossa, buccal mucosa (recurrence extending into bone), anterior mandible (intraosseous primary, focally extending into soft tissue), and left parotid and submandibular gland (with metaplastic bone) regions.
  • Tumor sizes ranged from 1.0 to 5.7 cm, median 3.5 cm.
  • Histologically, the tumors were well delineated and multinodular, separated by fibrous septae.
  • The spindled to primarily epithelioid tumor cells formed moderately cellular sheets and cords of irregularly contoured medium to large, round to oval, occasionally overlapping nuclei, indistinct nucleoli, wispy eosinophilic (retracting) cytoplasm, and distinctive cytoplasmic borders, embedded in osteoid-like stroma.
  • Three tumors were graded as 2/3 and two 1/3.
  • Immunohistochemically, the tumor cells were positive for vimentin, 1 case focally for CD34, whereas all cases were negative for S100 protein, keratins, EMA, desmin, and SMA.
  • The differential diagnosis for these tumors in this site includes sclerosing carcinoma, Ewing/PNET, osteosarcoma, osteoblastoma, and benign and malignant myoepithelial salivary gland tumors.
  • The collagen, focal spindle cell features, HPC-like vasculature, and weak focal CD34 reactivity in one case might have raised a possible relationship between OMFRSEF and low grade malignant solitary fibrous tumor, but the intraosseous propensity, epithelioid features and relative lack of CD34 make this a distinctive entity.
  • [MeSH-minor] Adult. Apoptosis. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Leiomyoma / diagnosis. Male. Middle Aged. Sclerosis. Solitary Fibrous Tumors / diagnosis. Young Adult

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  • [ErratumIn] Head Neck Pathol. 2013 Mar;7(1):103
  • (PMID = 20614275.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807507
  • [Keywords] NOTNLM ; Maxillofacial / Oral / Sarcoma / Sclerosing epithelioid fibrosarcoma
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99. Smith RB, Robinson RA, Hoffman HT, Graham MM: Preoperative FDG-PET imaging to assess the malignant potential of follicular neoplasms of the thyroid. Otolaryngol Head Neck Surg; 2008 Jan;138(1):101-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: When a fine needle aspiration biopsy of a thyroid nodule suggests follicular neoplasm, surgery is required for diagnosis.
  • SUBJECTS AND METHODS: Twenty-three patients with a diagnosis of follicular neoplasm underwent presurgical FDG-PET at 60, 90, and 120 minutes after injection of fluorodeoxyglucose (F18).
  • RESULTS: There were 5 malignant conditions and 18 benign conditions identified with the standard uptake valve (SUV) ranging from 0.9 to 44.8.
  • The SUV increased in 80% of the malignant cases but in only 50% of the benign cases.
  • CONCLUSION: Despite certain patterns being suggestive of malignancy, FDG-PET can not consistently predict the malignant potential of a follicular neoplasm.
  • [MeSH-minor] Adult. Aged. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Prospective Studies. Reproducibility of Results. Thyroidectomy / methods

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  • (PMID = 18165002.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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100. Bekler H, Gokce A, Beyzadeoglu T: Chondroid syringoma of the hand: a rare localization. Handchir Mikrochir Plast Chir; 2007 Dec;39(6):430-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondroid syringoma is a rare benign neoplasm of the sweat glands that usually occurs in the head and neck region.
  • We describe a 18-year-old male patient with a benign chondroid syringoma that occurred at an unusual site, leading to compression symptoms of the ulnar nerve causing symptoms at the hypothenar region of the right hand.
  • Although it is a rare tumor at an unusual site, it should be included in the differential diagnosis of the hand tumors.
  • [MeSH-minor] Adolescent. Biopsy. Humans. Image Enhancement. Magnetic Resonance Imaging. Male. Muscle, Skeletal / pathology. Neoplasm Invasiveness

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  • (PMID = 18058676.001).
  • [ISSN] 0722-1819
  • [Journal-full-title] Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der Peripheren Nerven und Gefässe : Organ der Vereinigung der Deutschen Plastischen Chirurgen
  • [ISO-abbreviation] Handchir Mikrochir Plast Chir
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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