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1. Falavigna A, Righesso O, Volquind D, Teles AR: Intramuscular myxoma of the cervical paraspinal muscle. Eur Spine J; 2009 Jul;18 Suppl 2:245-9
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  • [Title] Intramuscular myxoma of the cervical paraspinal muscle.
  • Myxoma is a neoplasm of mesenchymal origin composed of undifferentiated stellate cells in a myxoid stroma.
  • Only ten cases of these benign tumors involving the neck muscles were reported in literature.
  • A 64-year-old woman presented with occipital and neck pain over 5 years noted an expansive painful lesion located at posterior cervical region with progressive volume increase in the last 12 months.
  • Image exams revealed a large mass located in the left posterior region of the neck in contact with the C2, C3 and C4 laminae with no invasion of the vertebrae.
  • Tumor total removal was performed through normal muscle margins and the vertebral periosteum was scraped.
  • We reported the fourth case of intramuscular myxoma in the paraspinal musculature of the neck.
  • Despite its benign characteristics, local recurrence was reported after subtotal resection.
  • [MeSH-major] Cervical Vertebrae. Muscle Neoplasms / diagnosis. Muscle, Skeletal. Myxoma / diagnosis

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  • (PMID = 19301043.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 20
  • [Other-IDs] NLM/ PMC2899565
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2. Zhou M, Reuther AM, Levin HS, Falzarano SM, Kodjoe E, Myles J, Klein E, Magi-Galluzzi C: Microscopic bladder neck involvement by prostate carcinoma in radical prostatectomy specimens is not a significant independent prognostic factor. Mod Pathol; 2009 Mar;22(3):385-92
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  • [Title] Microscopic bladder neck involvement by prostate carcinoma in radical prostatectomy specimens is not a significant independent prognostic factor.
  • The independent prognostic importance of microscopic bladder neck involvement by prostate cancer in radical prostatectomy is questionable.
  • We studied a cohort of 1845 patients to determine the significance of microscopic bladder neck involvement.
  • Bladder neck involvement was defined as prostate cancer present within the coned bladder neck.
  • We further categorized the cases as 'true bladder neck involvement' and 'false bladder neck involvement.
  • ' True bladder neck involvement required prostate cancer within thick smooth muscle bundles without intermixed benign prostatic glands.
  • False bladder neck involvement was characterized by prostate cancer intermixed with benign prostatic glands.
  • Bladder neck involvement was analyzed in relation to preoperative serum prostate-specific antigen (PSA) level, extraprostatic extension, seminal vesicle involvement, positive surgical margin, lymph node involvement, radical prostatectomy Gleason score, and tumor volume.
  • Of the 90 patients (4.9%) with microscopic bladder neck involvement, 63 were further classified as true bladder neck involvement and 27 as false bladder neck involvement.
  • In univariate model, both types of bladder neck involvement (P<0.001), true (P<0.001), and false (P=0.040), were significantly associated with increased PSA-recurrence risk compared to bladder neck negative cases.
  • In multivariate model the PSA-recurrence relative risk associated with bladder neck involvement (true or false) was not a significant independent prognostic factor.
  • The time to biochemical recurrence in patients with bladder neck involvement was similar to that of pT2 with positive surgical margin or pT3a with negative surgical margin patients (Kaplan-Meier curves).
  • Bladder neck involvement was associated with other adverse pathologic features, but was not an independent predictor of PSA recurrence.
  • In view of the previous and current data, the staging system for bladder neck involvement should be revised and patients may be best categorized as having pT3a disease.
  • [MeSH-minor] Aged. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Prognosis. Prostate-Specific Antigen / blood. Prostatectomy

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  • (PMID = 19043400.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen
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3. Lincoln DT, Singal PK, Al-Banaw A: Growth hormone in vascular pathology: neovascularization and expression of receptors is associated with cellular proliferation. Anticancer Res; 2007 Nov-Dec;27(6B):4201-18
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  • Growth hormone (GH) is mitogenic for a variety of vascular tissue cells, including smooth muscle cells, fibroblasts and endothelial cells and exerts its regulatory functions in controlling metabolism, balanced growth and differentiated cell expression by acting on specific membrane-bound receptors, which trigger a phosphorylation cascade resulting in the modulation of numerous signalling pathways and of gene expression.
  • A total of 64 benign and malignant vascular tumours were obtained from different human organ sites, including the chest wall, skin, axillary contents, duodenum, female breast, abdomen, stomach, colon, lymph node, bladder, body flank and neck regions.
  • The presence of GHR in endothelial cells of vascular neoplasm indicates that they are target cells and GH is of importance in the proliferation of vascular tumour angiogenesis.

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  • [ErratumIn] Anticancer Res. 2008 Mar-Apr;28(2b):1439
  • (PMID = 18225592.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Receptors, Somatotropin; 9002-72-6 / Growth Hormone
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4. O'Callaghan MG, House M, Ebay S, Bhadelia R: Rhabdomyoma of the head and neck demonstrated by prenatal magnetic resonance imaging. J Comput Assist Tomogr; 2005 Jan-Feb;29(1):130-2
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  • [Title] Rhabdomyoma of the head and neck demonstrated by prenatal magnetic resonance imaging.
  • A case of fetal rhabdomyoma (myxoid type) of the head and neck demonstrated on prenatal magnetic resonance imaging (MRI) is presented.
  • This benign tumor of skeletal muscle is uncommon and should not be confused with its malignant counterpart-rhabdomyosarcoma.
  • With the increasing use of ultrafast MRI, the radiologist is more likely to encounter head and neck masses in the fetus.
  • [MeSH-major] Fetal Diseases / diagnosis. Head and Neck Neoplasms / diagnosis. Magnetic Resonance Imaging. Prenatal Diagnosis. Rhabdomyoma / diagnosis
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Gestational Age. Humans. Infant, Newborn. Neoplasm Recurrence, Local / pathology. Pregnancy. Ultrasonography, Prenatal


5. Ryś J, Kruczak A, Marczyk E, Skotnicki P, Moskal J, Ambicka A, Harazin-Lechowska A, Wasilewska A, Vogelgesang M, Dyczek S: Primary soft tissue giant cell tumour of the neck. Cytological and histological characteristics of the tumour and differential diagnosis. Pol J Pathol; 2009;60(2):98-104; quiz 105
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  • [Title] Primary soft tissue giant cell tumour of the neck. Cytological and histological characteristics of the tumour and differential diagnosis.
  • Giant cell tumour of soft part is a very rare neoplasm.
  • The deep-situated giant cell tumours of the neck are extremely rare.
  • That is why we report a case of primary giant cell tumour of soft part localized in the trapezius muscle of a 19-year-old woman.
  • We present both cytological and histological picture of the neoplasm.
  • [MeSH-major] Giant Cell Tumors / pathology. Head and Neck Neoplasms / pathology. Muscle, Skeletal / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Osteosarcoma / diagnosis. Sarcoma, Synovial / diagnosis. Synovitis, Pigmented Villonodular / diagnosis. Treatment Outcome. Young Adult

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  • (PMID = 19886185.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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6. Moore T, McLain RF: Image-guided surgery in resection of benign cervicothoracic spinal tumors: a report of two cases. Spine J; 2005 Jan-Feb;5(1):109-14

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  • [Title] Image-guided surgery in resection of benign cervicothoracic spinal tumors: a report of two cases.
  • BACKGROUND CONTEXT: Osseous spinal tumors are an uncommon cause of persistent axial pain and muscle spasm, but even benign lesions may grow to cause deformity or neurological signs.
  • Traditional treatment approaches to resection can be debilitating even when the tumor is benign.
  • STUDY DESIGN: Technical considerations are presented through two cases of benign osseous neoplasm occurring in the cervicothoracic spine of competitive athletes, demonstrating the meth-ods used to provide effective treatment while maintaining maximal functional capacity.
  • Used in combination with minimally invasive, microsurgical techniques,stereotactic guidance localized and verified excision margins of benign vertebral lesions, minimizing soft tissue trauma and collateral damage.
  • RESULTS: Computer-assisted stereotactic localization allowed us to successfully ablate these lesions from their anatomically challenging locations, without disrupting the shoulder girdle or neck musculature, and without extensive bony resection.
  • CONCLUSIONS: Image guidance can accurately localize and guide excision of benign vertebral lesions while minimizing soft tissue trauma and collateral damage, allowing patients a rapid and complete return to high-demand function.

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  • (PMID = 15739278.001).
  • [ISSN] 1529-9430
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Mentzel T, Kutzner H: Dermatomyofibroma: clinicopathologic and immunohistochemical analysis of 56 cases and reappraisal of a rare and distinct cutaneous neoplasm. Am J Dermatopathol; 2009 Feb;31(1):44-9
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  • [Title] Dermatomyofibroma: clinicopathologic and immunohistochemical analysis of 56 cases and reappraisal of a rare and distinct cutaneous neoplasm.
  • Dermatomyofibroma represents a rare and distinct benign cutaneous mesenchymal neoplasm of fibroblastic/myofibroblastic differentiation.
  • The shoulder (13 cases) was the anatomic site most commonly affected, followed by the upper arm (7 cases), the neck (6 cases), the thigh (6 cases), the chest wall (4 cases), the back (3 cases), the axillary fold (2 cases), the abdominal wall (2 cases), and 1 case each was seen on the forearm, the buttock, and the popliteal fossa (exact anatomic location was unknown in 10 cases).
  • Histologically, an ill-defined, plaque-like dermal neoplasm of varying cellularity was seen in all cases, composed of bland spindle-shaped tumor cells often oriented parallel to the overlying epidermis.
  • Immunohistochemically, tumor cells in 11 of 48 cases tested stained positively for alpha-smooth muscle actin, and a focal expression of this marker was noted in 20 cases.
  • Dermatomyofibroma represents a benign fibroblastic/myofibroblastic dermal neoplasm.
  • [MeSH-major] Histiocytoma, Benign Fibrous / metabolism. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / metabolism. Skin Neoplasms / pathology

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  • (PMID = 19155724.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Juhlin J, Eiholm S: [Rhabdomyoma in the head and neck region]. Ugeskr Laeger; 2009 Mar 30;171(14):1194
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  • [Title] [Rhabdomyoma in the head and neck region].
  • Extracardiac rhabdomyoma is an extremely uncommon benign neoplasm with skeletal muscle differentiation which usually involves the head and neck region.
  • In both cases, an asymptomatic neck mass was noticed by the patient.
  • Adult rhabdomyomas should be considered as a differential diagnosis in the head and neck region.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Rhabdomyoma / diagnosis

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  • (PMID = 19338741.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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9. Gleason BC, Fletcher CD: Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential. Am J Surg Pathol; 2008 Mar;32(3):354-62
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  • [Title] Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential.
  • Benign fibrous histiocytoma (FH) is one of the most common mesenchymal neoplasms of the skin.
  • Deep benign FH is an uncommon and poorly recognized clinical subtype that arises in subcutaneous or deep soft tissue.
  • The most common anatomic location was the extremities (58%); the remainder arose on the head and neck (22%), trunk (11%), and in the deep soft tissue of the retroperitoneum, mediastinum, or pelvis (9%).
  • Immunohistochemistry revealed expression of CD34 in 20/50 cases (40%), smooth muscle actin in 15/40 (38%), and focal desmin in 1/12 (8%).
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Neoplasm Metastasis / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Actins / analysis. Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD34 / analysis. Child. Desmin / analysis. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mitosis. Necrosis. Neoplasm Recurrence, Local

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  • (PMID = 18300816.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD34; 0 / Desmin
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10. Dimitrakopoulos I, Lasaridis N, Asimaki A: Primary malignant peripheral nerve sheath tumour in the temporalis muscle. J Craniomaxillofac Surg; 2008 Jul;36(5):300-3

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  • [Title] Primary malignant peripheral nerve sheath tumour in the temporalis muscle.
  • In the head and neck where the great majority of peripheral nerve neoplasms are benign, as in the rest of the body, malignant peripheral nerve sheath tumours (MPNSTs) are unusual lesions.
  • PATIENT: A case of a large MPNST is reported, which originated in the left temporalis muscle of a 74-year-old man who did not suffer from von Recklinghausen's disease.
  • DISCUSSION: The clinicopathologic properties of this neoplasm have been widely discussed and the emphasis is on the need for its early identification since the tumour's non-specific symptoms may result in delayed diagnosis and treatment.
  • CONCLUSION: To date, to our knowledge, no case of MPNST located in the temporalis muscle has been described.
  • [MeSH-major] Muscle Neoplasms / pathology. Nerve Sheath Neoplasms / pathology. Temporal Muscle / pathology
  • [MeSH-minor] Aged. Fatal Outcome. Humans. Male. Neoplasm Recurrence, Local / surgery

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  • (PMID = 18367405.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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11. Durgun Y, Firat C, Miman MC, Kirimlioglu H: A rare benign laryngeal tumor: angiomyolipoma. J Craniofac Surg; 2010 Nov;21(6):1956-7

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  • [Title] A rare benign laryngeal tumor: angiomyolipoma.
  • Angiomyolipoma is a mesenchymal neoplasm containing adipose tissue, blood vessels, and smooth muscle fibers.
  • Arising most frequently in the kidney, the tumor may exceptionally be at the head and neck region.

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  • (PMID = 21119467.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Bisdas S, Baghi M, Huebner F, Mueller C, Knecht R, Vorbuchner M, Ruff J, Gstoettner W, Vogl TJ: In vivo proton MR spectroscopy of primary tumours, nodal and recurrent disease of the extracranial head and neck. Eur Radiol; 2007 Jan;17(1):251-7
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  • [Title] In vivo proton MR spectroscopy of primary tumours, nodal and recurrent disease of the extracranial head and neck.
  • Benign and malignant neoplasms as well as metastatic lymph nodes of 39 patients were examined using localized single voxel magnetic resonance spectroscopy (MRS) [repetition time (TR) 1500, echo time (TE) 135) at 1.5 T.
  • The Cho/Cr ratios in all malignant neoplasms (mean: 5.2, range: 1.7-17.8) were significantly elevated relative to those in the normal muscle structures (mean: 0.9, range: 0.2-1.4), while those in the benign neoplasms were elevated (mean: 24.4, range: 1.4-59.7) with respect to those in the malignant ones.
  • The average Cho/Cr ratio in the metastatic lymph nodes was significantly higher (mean: 4.8, range: 3.3-5.6) than that for benign lymphoid hyperplasia (mean: 2.2, range: 1.0-3.0).
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Magnetic Resonance Spectroscopy. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 16703309.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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13. Hornick JL, Fletcher CD: Cellular neurothekeoma: detailed characterization in a series of 133 cases. Am J Surg Pathol; 2007 Mar;31(3):329-40
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  • Cellular neurothekeomas are distinctive benign cutaneous tumors of uncertain histogenesis.
  • The tumors arose most often on the upper limb (35%) or head and neck (33%).
  • In 30% of cases, neurothekeoma was suggested by the referring pathologist; the most common other diagnoses offered were plexiform fibrohistiocytic tumor, benign fibrous histiocytoma, and a low-grade sarcoma.
  • Histologically, most cases were poorly marginated; 33 (25%) infiltrated fat, and 10 (8%) entrapped skeletal muscle (all but 1 situated on the face).
  • All tumors were reactive for NKI-C3, 110/123 (89%) expressed neuron-specific enolase, 73/127 (57%) showed at least focal staining for smooth muscle actin, and only 1 was focally desmin positive.
  • Cellular neurothekeomas have a predilection for the upper limbs and head and neck of pediatric and young adult females and rarely recur following incomplete excision.
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Child. Child, Preschool. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Immunohistochemistry. Infant. Male. Middle Aged. Mitosis. Neoplasm Recurrence, Local. Sarcoma / diagnosis

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  • (PMID = 17325474.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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14. Bekler H, Gokce A, Beyzadeoglu T: Chondroid syringoma of the hand: a rare localization. Handchir Mikrochir Plast Chir; 2007 Dec;39(6):430-2
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  • Chondroid syringoma is a rare benign neoplasm of the sweat glands that usually occurs in the head and neck region.
  • We describe a 18-year-old male patient with a benign chondroid syringoma that occurred at an unusual site, leading to compression symptoms of the ulnar nerve causing symptoms at the hypothenar region of the right hand.
  • [MeSH-minor] Adolescent. Biopsy. Humans. Image Enhancement. Magnetic Resonance Imaging. Male. Muscle, Skeletal / pathology. Neoplasm Invasiveness

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  • (PMID = 18058676.001).
  • [ISSN] 0722-1819
  • [Journal-full-title] Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der Peripheren Nerven und Gefässe : Organ der Vereinigung der Deutschen Plastischen Chirurgen
  • [ISO-abbreviation] Handchir Mikrochir Plast Chir
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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15. Jin B, Saleh H: Pitfalls in the diagnosis of adult rhabdomyoma by fine needle aspiration: report of a case and a brief literature review. Diagn Cytopathol; 2009 Jul;37(7):483-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Fine needle aspiration (FNA) is a valuable, noninvasive, commonly used technique in the diagnoses of head and neck tumors.
  • Adult rhabdomyoma is a rare benign tumor of striate muscle tissue usually located in the head and neck region.
  • [MeSH-major] Muscle Proteins / metabolism. Neoplasm Proteins / metabolism. Rhabdomyoma / metabolism. Rhabdomyoma / pathology

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  • [Copyright] 2009 Wiley-Liss, Inc.
  • (PMID = 19217050.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Muscle Proteins; 0 / Neoplasm Proteins
  • [Number-of-references] 13
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16. Lanza A, Moscariello A, Villani R, Colella G: Glomus tumor of the lower lip. A case report. Minerva Stomatol; 2005 Nov-Dec;54(11-12):687-90

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A glomus tumor is a benign neoplasm originating from the modified smooth muscle cells of the vascular glomus.
  • This neoplasm was firstly considered by Masson in 1924, and generally it has a solitary lesions but in some cases multiple lesions were described.

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  • (PMID = 16456522.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng; ita
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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17. Patsiaoura K, Anagnostou E, Benis N: Intramuscular myxoma of the nasal vestibule. Auris Nasus Larynx; 2010 Feb;37(1):100-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Intramuscular myxoma is an uncommon benign soft tissue neoplasm and a distinct histopathological entity within the heterogeneous group of myxomas.
  • The head and neck region is an uncommon site of presentation for intramuscular myxoma with only 13 documented cases in the available literature.
  • To the very best of our knowledge, there is no report of this neoplasm located within the nasal and oral mimetic muscles.
  • [MeSH-major] Muscle, Skeletal / pathology. Myxoma / pathology. Paranasal Sinus Neoplasms / pathology

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  • [Copyright] Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19414229.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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18. Watanabe H, Ishida Y, Nagashima K, Makino T, Norisugi O, Shimizu T: Desmoplastic fibroblastoma (collagenous fibroma). J Dermatol; 2008 Feb;35(2):93-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This report describes a case of DF that appeared on the left side of the neck of a 55-year-old male as a 3.5-cm solitary, firm nodule.
  • The entrapment of fat and muscle tissues was focally identified at the edges of the tumor.
  • The stellate and multinucleated cells in the lesion were strongly positive for vimentin but negative for cytokeratin, smooth muscle actin, desmin, S-100, CD34, factor XIIIa, and CD68.
  • These findings suggest that the stellate and multinucleated cells in the lesion were of fibroblastic origin and this neoplasm was pathologically benign.
  • [MeSH-major] Fibroma / pathology. Head and Neck Neoplasms / pathology

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  • (PMID = 18271804.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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19. Chi AC, Barnes JD, Budnick S, Agresta SV, Neville B: Rhabdomyosarcoma of the maxillary gingiva. J Periodontol; 2007 Sep;78(9):1839-45
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Rhabdomyosarcoma is a malignant neoplasm of primitive mesenchyme exhibiting skeletal muscle differentiation.
  • Oral rhabdomyosarcoma is rare and accounts for only 0.04% of all head and neck malignancies.
  • Pain is a variable presenting symptom, and early lesions may be mistaken for benign neoplastic, inflammatory, or infectious processes.

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  • (PMID = 17760557.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 51
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20. Agaimy A, Wünsch PH, Schroeder J, Gaumann A, Dietmaier W, Hartmann A, Hofstaedter F, Mentzel T: Low-grade abdominopelvic sarcoma with myofibroblastic features (low-grade myofibroblastic sarcoma): clinicopathological, immunohistochemical, molecular genetic and ultrastructural study of two cases with literature review. J Clin Pathol; 2008 Mar;61(3):301-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIMS: Low-grade myofibroblastic sarcoma (LGMS) represents a rare soft tissue neoplasm with a predilection for the head and neck.
  • The tumour cells strongly expressed vimentin, variably alpha-smooth muscle actin and fibronectin, but were negative for CD117, S-100, desmin, h-caldesmon, beta-catenin, ALK-1, MDM2, PDGFRalpha and PDGFRbeta.
  • LGMS may mimic a variety of benign and low-grade malignant neoplasms and might be under-recognised.
  • [MeSH-major] Neoplasm Recurrence, Local / ultrastructure. Peritoneal Neoplasms / ultrastructure. Sarcoma / ultrastructure. Soft Tissue Neoplasms / ultrastructure

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  • (PMID = 17513510.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Fibronectins; 0 / Vimentin; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha
  • [Number-of-references] 38
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21. Zolota V, Tzelepi V, Charoulis N, Apostolakis E, Dougenis D: Mediastinal rhabdomyoma: case report and review of the literature. Virchows Arch; 2006 Jul;449(1):124-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Rhabdomyomas are benign tumors in which at least some cells are differentiated as skeletal muscle cells with cytoplasmic cross-striations.
  • Extracardiac adult rhabdomyoma is an extremely uncommon benign neoplasm that usually involves the head and neck region.

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  • [Cites] Am J Surg Pathol. 1992 Jul;16(7):721-8 [1530111.001]
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  • (PMID = 16636850.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Desmin; 0 / Myoglobin
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22. Mentzel T, Dei Tos AP, Sapi Z, Kutzner H: Myopericytoma of skin and soft tissues: clinicopathologic and immunohistochemical study of 54 cases. Am J Surg Pathol; 2006 Jan;30(1):104-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Immunohistochemical stainings using alpha-smooth muscle actin (ASMA), desmin, and h-caldesmon antibodies were performed, and clinical data and follow-up information were obtained from referring pathologists.
  • The lower extremities were most commonly affected (26 cases) followed by the upper extremities (16 cases), the head and neck region (4 cases), and the trunk (2 cases); exact location was unknown in 5 cases.
  • Despite overlapping morphologic features to angioleiomyoma and myofibroma, myopericytoma represents a distinct perivascular, myoid neoplasm of skin and soft tissues, characterized by a broad morphologic spectrum of concentrically, perivascularly growing myoid tumor cells that stain positively for ASMA and often for h-caldesmon, whereas desmin is usually negative.
  • Most cases of myopericytoma behave in a benign fashion, but local recurrences and rarely metastases may occur in atypical and malignant neoplasms.

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  • (PMID = 16330949.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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23. Mandal RV, Duncan LM, Austen WG Jr, Nielsen GP: Infiltrating intramuscular spindle cell lipoma of the face. J Cutan Pathol; 2009 Oct;36 Suppl 1:70-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Spindle cell lipoma is a benign lipomatous tumor, which usually arises on the back of the neck, shoulder or upper back of males in the third to seventh decade of life.
  • Histologically, a proliferation of mature adipocytes, ropey collagen fibers and spindle cells within a myxoid stroma was present in the subcutaneous tissue and infiltrated between skeletal muscle fibers.
  • [MeSH-major] Lipoma / pathology. Neoplasm Recurrence, Local / pathology. Nose Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19187113.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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24. Hausbrandt PA, Leithner A, Beham A, Bodo K, Raith J, Windhager R: A rare case of infantile myofibromatosis and review of literature. J Pediatr Orthop B; 2010 Jan;19(1):122-6
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  • Infantile myofibromatosis is a rare benign tumor-disease (1/400,000).
  • The most commonly affected body areas are the head, the neck, and the trunk.
  • Infantile myofibromatosis is a very rare benign tumor-disease.
  • Histopathologically, cells characteristically appear as spindle-shaped fibroblast cells with pale pink cytoplasm and elongated nuclei and the immunophenotype is defined with a positive reaction on smooth-muscle antigen vimentin and the muscle-specific antigen HHF-35.
  • [MeSH-minor] Calcinosis / pathology. Calcinosis / physiopathology. Diagnosis, Differential. Follow-Up Studies. Frozen Sections. Histiocytosis, Langerhans-Cell / diagnosis. Humans. Infant. Male. Neoplasm Regression, Spontaneous

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  • (PMID = 19738495.001).
  • [ISSN] 1473-5865
  • [Journal-full-title] Journal of pediatric orthopedics. Part B
  • [ISO-abbreviation] J Pediatr Orthop B
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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25. Ahn JY, Kang SY, Lee CH, Yoon PH, Lee KS: Parapharyngeal branchial cleft cyst extending to the skull base: a lateral transzygomatic-transtemporal approach to the parapharyngeal space. Neurosurg Rev; 2005 Jan;28(1):73-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Second BCCs usually lie on the great vessels of the neck, deep in the sternocleoidomastoid muscle or along its anterior border at the mandibular angle.
  • Parapharyngeal second BCCs are an uncommon neoplasm and rarely extend to the skull base.
  • We conclude the lateral transzygomatic-transtemporal approach allows surgeons direct access to the parapharyngeal space with satisfactory exposure for treating benign lesions of the parapharyngeal space.
  • [MeSH-minor] Humans. Male. Middle Aged. Neoplasm Invasiveness. Skull Base / pathology. Skull Base / surgery. Temporal Bone / surgery. Zygoma / surgery

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  • (PMID = 15586258.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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26. Ward JL, Prieto VG, Joseph A, Chevray P, Kronowitz S, Sturgis EM: Neurothekeoma. Otolaryngol Head Neck Surg; 2005 Jan;132(1):86-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Six of the lesions were on the head or neck, 4 were on extremities, and 2 were on the trunk, and the location of 1 was not recorded.
  • Most cases were limited to the dermis, but 2 lesions infiltrated subcutaneous tissue and skeletal muscle.
  • CONCLUSION: Neurothekeoma is a benign neoplasm occurring usually in women and commonly in the head and neck.
  • [MeSH-major] Head and Neck Neoplasms. Neurothekeoma

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  • (PMID = 15632914.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Ali TZ, Epstein JI: Basal cell carcinoma of the prostate: a clinicopathologic study of 29 cases. Am J Surg Pathol; 2007 May;31(5):697-705
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Infiltration around benign glands was seen in 10 (36%) cases, with predominantly small nests and AC-P.
  • Invasion of thick muscle bundles of the bladder neck was seen in 10 of 21 TURP cases.
  • An additional 11 cases showed extraprostatic extension on TURP with bladder neck invasion (n=10) or periprostatic adipose tissue invasion (n=1).
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Biopsy, Needle. Combined Modality Therapy. Humans. Male. Middle Aged. Mitosis. Neoplasm Recurrence, Local. Retrospective Studies. Transurethral Resection of Prostate

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  • (PMID = 17460452.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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28. Basu D, Sengupta A, Adhikari D, Dam A, Anwar T: Granular cell myoblastoma of the tongue in a 2-year-old girl: a case report. J Indian Med Assoc; 2010 Mar;108(3):170, 175
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Granular cell tumours are uncommon lesions, although the head and neck region accounts for approximately 50% of all lesions.
  • It is not clear whether or not granular cell tumour is a true neoplasm, a developmental anomaly, or a trauma-induced proliferation.
  • The basic cell of origin is now thought to be neural, although past reports frequently indicated an origin from striated muscle, or less frequently an origin from histiocytes, fibroblasts or pericytes.
  • The other head and neck site likely to be involved is the larynx.
  • Histochemical and ultrastructural studies propose the origin of the lesion from Schwann cells, striated muscle, mesenchymal cells, histiocytes and epithelial cells.
  • As most of the granular cell tumours are benign, surgical excision of the lesion is the treatment of choice.

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  • (PMID = 21043356.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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29. Folpe AL, Mentzel T, Lehr HA, Fisher C, Balzer BL, Weiss SW: Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature. Am J Surg Pathol; 2005 Dec;29(12):1558-75
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  • PEComas, occasionally associated with the tuberous sclerosis complex, are defined by the presence of perivascular epithelioid cells that coexpress muscle and melanocytic markers.
  • Immunohistochemistry for pan-cytokeratin (CK), S-100 protein, smooth muscle actins (SMA), desmin, vimentin, HMB45, Melan-A, microphthalmia transcription factor (MiTF), TFE3, CD117, and CD34 was performed.
  • Sites of involvement included the omentum or mesentery (6 cases), uterus (4 cases), pelvic soft tissues (3 cases), abdominal wall (2 cases), uterine cervix (2 cases), and vagina, retroperitoneum, thigh, falciform ligament, scalp, broad ligament, forearm, shoulder, and neck (1 case each).
  • We conclude that PEComas of soft tissue and gynecologic origin may be classified as "benign," "of uncertain malignant potential," or "malignant."
  • Small PEComas without any worrisome histologic features are most likely benign.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Follow-Up Studies. Humans. Immunohistochemistry. Immunophenotyping. Male. Middle Aged. Mitosis. Neoplasm Metastasis. Neoplasm Recurrence, Local. Retrospective Studies. Survival Analysis. Time Factors. Treatment Outcome. Tumor Burden

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  • (PMID = 16327428.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 56
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