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6. Vázquez Camacho EE, Cabrera Carranco E, Sánchez Herrera RG: [Pedunculated twisted myoma and pregnancy. Case report]. Ginecol Obstet Mex; 2009 Sep;77(9):441-4
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  • [Title] [Pedunculated twisted myoma and pregnancy. Case report].
  • [Transliterated title] Mioma pediculado torcido en una mujer embarazada. Reporte de caso.
  • We report a case of a woman at the 15 week of gestation with torsi6n of a pedunculated mioma mimicking in the ultrasonografic image an ovarian tumor.

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  • (PMID = 19899435.001).
  • [ISSN] 0300-9041
  • [Journal-full-title] Ginecología y obstetricia de México
  • [ISO-abbreviation] Ginecol Obstet Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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7. Yoon HJ, Kyung MS, Jung US, Choi JS: Laparoscopic myomectomy for large myomas. J Korean Med Sci; 2007 Aug;22(4):706-12
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  • [Title] Laparoscopic myomectomy for large myomas.
  • The aim of this study was to assess the feasibility and efficacy of laparoscopic myomectomy (LM) for large myomas.
  • A subpopulation of 51 patients with myomas 8 cm or larger in diameter was selected from 155 patients who underwent LM at Kangbuk Samsung Hospital from July 2003 to November 2006.
  • The mean operating time was 85.6 +/- 38.9 min, and the mean diameter of the largest myoma was 9.3 +/- 1.8 cm.
  • With the newly-developed screw and the port placement system that was modified from the Choi's 4-trocar method to obtain better surgical vision, LM of large myomas proved to be one of the efficient and feasible methods.

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  • (PMID = 17728514.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2693824
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8. Kotini A, Anastasiadis AN, Anninos P, Koutlaki N, Anastasiadis P: Nonlinear analysis of biomagnetic signals recorded from uterine myomas. Biomagn Res Technol; 2006;4:2
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  • [Title] Nonlinear analysis of biomagnetic signals recorded from uterine myomas.
  • OBJECTIVE: To determine if there is any non-linearity in the biomagnetic recordings of uterine myomas and to find any differences that may be present in the mechanisms underlying their signal dynamics.
  • Sixteen of them were characterised with large myomas and 8 with small ones.
  • RESULTS: Applying nonlinear analysis to the biomagnetic signals of the uterine myomas, we observed a clear saturation value for the group of large ones (mean = 11.35 +/- 1.49) and no saturation for the small ones.
  • CONCLUSION: The comparison of the saturation values in the biomagnetic recordings of large and small myomas may be a valuable tool in the evaluation of functional changes in their dynamic behavior.

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  • (PMID = 16571144.001).
  • [ISSN] 1477-044X
  • [Journal-full-title] Biomagnetic research and technology
  • [ISO-abbreviation] Biomagn Res Technol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1484479
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9. Pérez-Cejudo JA, Piqué E, Arduan I, Palacios S, Sánchez C, Rodríguez M, Morales R: [Umbilical cutaneous endometriosis associated with a large uterine myoma]. Actas Dermosifiliogr; 2005 Jan-Feb;96(1):43-5
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  • [Title] [Umbilical cutaneous endometriosis associated with a large uterine myoma].
  • [Transliterated title] Endometriosis cutánea umbilical asociada a mioma uterino gigante.
  • The Dermatology Department was consulted because of an asymptomatic umbilical tumor which had been developing for 5 years.
  • [MeSH-major] Endometriosis / complications. Leiomyoma / complications. Skin Diseases / complications. Umbilicus. Uterine Neoplasms / complications


10. Squillaci S, Cecchetti D, Tallarigo F, Pontieri F, Filardo AV: [Myopericytoma-type perivascular myoma located in the soft tissue of the foot: a case report and review of the literature]. Pathologica; 2005 Dec;97(6):378-82
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  • [Title] [Myopericytoma-type perivascular myoma located in the soft tissue of the foot: a case report and review of the literature].
  • [Transliterated title] Mioma perivascolare di tipo miopericitoma dei tessuti molli del piede: descrizione di un caso e revisione della letteratura.
  • We describe a rare case of myopericytoma-type perivascular myoma (MTPM) which arose in acral location and the literature on this field is briefly reviewed.
  • Immunohistochemically, the neoplastic cells were positive for vimentin, smooth muscle actin, desmin and calponin, negative for S-100 protein, CD34, CD31 and cytokeratins (AE1/AE3, Cam 5.2).
  • [MeSH-major] Foot Diseases / pathology. Myoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16619980.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 16
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11. McLucas B, Chespak L, Kaminsky D: Myoma necrosis following Gelfoam embolization of uterine myomata. Minim Invasive Ther Allied Technol; 2008;17(3):200-4
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  • [Title] Myoma necrosis following Gelfoam embolization of uterine myomata.

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  • (PMID = 18666018.001).
  • [ISSN] 1365-2931
  • [Journal-full-title] Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy
  • [ISO-abbreviation] Minim Invasive Ther Allied Technol
  • [Language] eng
  • [Publication-type] Comparative Study; Controlled Clinical Trial; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Hemostatics
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12. Palmara V, Triolo O, Benedetto V, Lo Re C, Sturlese E, Retto G, Santoro G: Morphologic patterns of human endometrial epithelium in women with uterine myomata treated with leuprorelin acetate. Gynecol Obstet Invest; 2010;69(2):131-5
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  • [Title] Morphologic patterns of human endometrial epithelium in women with uterine myomata treated with leuprorelin acetate.
  • AIM: We studied morphologic modifications of the endometrium induced by leuprorelin acetate, a gonadotropin-releasing hormone agonist, in women with uterine myomata.
  • RESULTS: A near-normal endometrium was observed after 2 months of therapy, while treatment with 6 cycles of leuprorelin acetate induced a uniform morphologic regression of the uterine mucosa.


13. Asciutto G, Mumme A, Marpe B, Hummel T, Asciutto KC, Geier B: Deep venous thrombosis in a patient with large uterine myomata. Case report. Minerva Ginecol; 2008 Oct;60(5):451-3
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  • [Title] Deep venous thrombosis in a patient with large uterine myomata. Case report.
  • Computed tomography revealed an inhomogenous uterine enlargement due to multiple myomata producing a thrombotic occlusion of the left iliac veins.
  • Uterine myomata rarely cause acute iliac vein thrombosis due to direct compression.


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4. Nezhat C, Kho K: Iatrogenic myomas: new class of myomas? J Minim Invasive Gynecol; 2010 Sep-Oct;17(5):544-50
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  • [Title] Iatrogenic myomas: new class of myomas?
  • Parasitic myomas, defined as extrauterine seeding of leiomyoma, have been reported since the early 1900s.
  • These myomas were thought to be spontaneously occuring, separate from the uterus but still hormone-dependent and can cause symptoms.
  • What seemed to be a rare disorder developing from the natural history of pedunculated myomas has become increasingly reported over the last decade.
  • Because it is still a rare disorder, the literature is limited to case reports.
  • [MeSH-major] Gynecologic Surgical Procedures / adverse effects. Leiomyoma / surgery. Neoplasm Seeding. Uterine Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Iatrogenic Disease. Middle Aged

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  • [Copyright] Copyright © 2010 AAGL. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20580324.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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15. Ghezzi F, Cromi A, Bergamini V, Scarperi S, Bolis P, Franchi M: Midterm outcome of radiofrequency thermal ablation for symptomatic uterine myomas. Surg Endosc; 2007 Nov;21(11):2081-5
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  • [Title] Midterm outcome of radiofrequency thermal ablation for symptomatic uterine myomas.
  • BACKGROUND: Over the past decade an increasing demand for uterine-sparing treatment to manage symptomatic uterine myomas has become apparent in women's health care.
  • The purpose of this study was to evaluate the midterm outcomes of radiofrequency ablation (RFA) of uterine myomas in terms of durability of symptom control and level of health-related quality of life.
  • METHODS: Consecutive women with symptomatic uterine myomas, no plans for future pregnancy, and who declined hysterectomy were offered RFA ablation of uterine fibroids under laparoscopic guidance.
  • Improvement in myoma-related symptoms and impact on quality of life were assessed using a validated questionnaire (UFS-QOL).
  • RESULTS: The median number of myomas treated per patient was 1 (range = 1-3).
  • The median baseline volume of the dominant myoma was 76.8 cm3 (range = 14.8-332.8).
  • The median reduction in myoma volume was 68.8% and 77.9% at six months and one year, respectively.

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  • (PMID = 17514400.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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16. Daneliia GS, Paĭlodze MV, Dgebuadze MA, Matitashvili SG: [Morpho-functional parameters of the corpus luteum in healthy women and in patients of reproductive age with uterine myoma]. Morfologiia; 2006;129(1):76-80
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  • [Title] [Morpho-functional parameters of the corpus luteum in healthy women and in patients of reproductive age with uterine myoma].
  • Ovarian corpus luteum of menstruation at the stage of its peak activity was studied in normal women and in patients with proliferative uterine myoma using ultrasonography (intravaginal color Doppler imaging), laboratory analyses (progesterone and estrogen concentrations in peripheral blood) and morphological (histological, histochemical and morphometric) methods.
  • In patients with proliferative uterine myoma, the defective corpus luteum was detected, as indicated by the prevalence of small granulosa lutein cells, insignificant amount and uneven distribution of lipid inclusions in their cytoplasm, marked reduction of progesterone concentration in peripheral blood, unechogenicity, low degree of vascularization and increase in the value of resistance index of ovarian stromal arteries.

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  • (PMID = 17201326.001).
  • [ISSN] 1026-3543
  • [Journal-full-title] Morfologii︠a︡ (Saint Petersburg, Russia)
  • [ISO-abbreviation] Morfologiia
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 4G7DS2Q64Y / Progesterone
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17. Bodle JF, Duffy SR, Binney DM: Susceptibility of uterine myomas and endometrium to cryosurgery using a carbon dioxide cryosurgical probe in vitro. J Minim Invasive Gynecol; 2006 Nov-Dec;13(6):500-4
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  • [Title] Susceptibility of uterine myomas and endometrium to cryosurgery using a carbon dioxide cryosurgical probe in vitro.
  • STUDY OBJECTIVE: To determine the effect of a 9-mm diameter carbon dioxide cryoprobe, the Endocryo, on myomas and endometrial/myometrial tissue in vitro.
  • DESIGN: Comparative laboratory study (Canadian Task Force classification II-2).
  • PATIENTS: Women with and without myomas, undergoing hysterectomy.
  • INTERVENTION: A single 5-minute freeze followed by an active thaw was applied to uterine myomas and endometrial/myometrial tissue in vitro.
  • MEASUREMENTS AND MAIN RESULTS: Endometrial/myometrial and uterine myoma temperature change was measured continuously during the cryosurgical procedure.
  • There was no significant difference in temperature change and depth of cell death between myomas and endometrial/myometrial tissue in vitro.
  • CONCLUSIONS: The Endocryo produces the same cryosurgical effect on both uterine myomas and endometrial/myometrial tissue in vitro, an important principal for future development of a clinically effective cryosurgical device for the treatment of menorrhagia in the presence of submucous myomas.

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  • (PMID = 17097569.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 142M471B3J / Carbon Dioxide
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18. Jansen FW, de Kroon CD, van Dongen H, Grooters C, Louwé L, Trimbos-Kemper T: Diagnostic hysteroscopy and saline infusion sonography: prediction of intrauterine polyps and myomas. J Minim Invasive Gynecol; 2006 Jul-Aug;13(4):320-4
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  • [Title] Diagnostic hysteroscopy and saline infusion sonography: prediction of intrauterine polyps and myomas.
  • STUDY OBJECTIVE: To compare the positive predictive value (PPV) of diagnostic hysteroscopy (DH) and saline infusion sonography (SIS) for the detection of myomas and polyps in patients with abnormal uterine bleeding.
  • DESIGN: All consecutive women referred to our University Hospital diagnosed with an intrauterine polyp or myoma by office DH or SIS were included in the study.
  • After hysteroscopic removal in an inpatient setting, histopathologic results were used as a gold standard to calculate PPV of SIS and DH. (Canadian Task Force classification II-3) SETTING: Tertiary referral center.
  • PATIENTS: Women in whom an intrauterine polyp or myoma was diagnosed either by DH or SIS MEASUREMENTS AND MAIN RESULTS: The PPVs of SIS and DH in the evaluation of intrauterine polyps and fibroids did not significantly differ.
  • CONCLUSIONS: Diagnostic hysteroscopy and saline infusion sonography are equivalent diagnostic tools for the detection of intrauterine myomas and polyps.

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  • (PMID = 16825074.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 451W47IQ8X / Sodium Chloride
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19. Kulishova TV, Tabashnikova NA, Akker LV: [Efficacy of general magnetotherapy in conservative therapy of uterine myoma in women of reproductive age]. Vopr Kurortol Fizioter Lech Fiz Kult; 2005 Jan-Feb;(1):26-8
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  • [Title] [Efficacy of general magnetotherapy in conservative therapy of uterine myoma in women of reproductive age].
  • Sixty women of the reproductive age with uterine myoma were divided into two groups.
  • Ultrasound investigation registered a reduction in the size of myoma nodes by 16.7% in the study group, while in the controls myoma size did not change (p < 0.05).
  • 1-year follow-up data for the study group demonstrated no cases of the myoma growth while 16.6% of the controls showed growth of myoma nodes, in 6.6% of them supravaginal myoma amputation was made for rapidly growing myoma.

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  • (PMID = 15759473.001).
  • [ISSN] 0042-8787
  • [Journal-full-title] Voprosy kurortologii, fizioterapii, i lechebnoĭ fizicheskoĭ kultury
  • [ISO-abbreviation] Vopr Kurortol Fizioter Lech Fiz Kult
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia
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20. Nappi L, Matteo M, Giardina S, Rosenberg P, Indraccolo U, Greco P: Management of uterine giant myoma. Arch Gynecol Obstet; 2008 Jul;278(1):61-3
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  • [Title] Management of uterine giant myoma.
  • BACKGROUND: Giant myomas of the uterus are uncommon, particularly in developed countries.
  • CASE: This report illustrates a case of a woman with a bilobated giant myoma of the uterus weighed in total 27.7 kg.
  • CONCLUSIONS: The knowledge of the different clinical manifestation of these myomas may allow to face that with adequate perioperative care, in order to assure a carefully and successfully surgery, although sometimes a benign pathology may be not easy to suspect in a first time.

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  • (PMID = 18066710.001).
  • [ISSN] 0932-0067
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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21. Parker WH: Uterine myomas: management. Fertil Steril; 2007 Aug;88(2):255-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Uterine myomas: management.
  • OBJECTIVE: To review the currently available literature regarding the current management alternatives available to women with uterine myomas.
  • DESIGN: Literature review of 198 articles pertaining to uterine myomas.
  • RESULT(S): Many advances have been made in the management of uterine myomas.
  • CONCLUSION(S): Many options are now available to women with uterine myomas.
  • The presently available literature regarding the treatment of myomas is summarized.
  • [MeSH-major] Myoma / therapy. Uterine Neoplasms / therapy

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  • (PMID = 17658523.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 33515-09-2 / Gonadotropin-Releasing Hormone; 4G7DS2Q64Y / Progesterone
  • [Number-of-references] 141
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22. Maia H Jr, Casoy J, Pimentel K, Correia T, Athayde C, Cruz T, Coutinho EM: Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies. Contraception; 2008 Dec;78(6):479-85
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  • [Title] Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies.
  • BACKGROUND: The study was conducted to evaluate vascular endothelial growth factor (VEGF), Cox-2 and aromatase expression in the endometrium of uteri with myomas and other associated pathologies.
  • STUDY DESIGN: Hysteroscopy was performed in 118 women of reproductive age with myomas and menorrhagia, 40 of whom were using a pill containing 75 mcg gestodene+30 mcg ethinylestradiol.
  • RESULTS: In patients with myomas and menorrhagia, associated pathologies such as adenomyosis, endometrial polyps and endometriosis were found in 32%, 12% and 17% of cases, respectively.
  • CONCLUSION: Endogenous progesterone or combined oral contraceptives are potent inhibitors of VEGF, aromatase and Cox-2 expression in the endometrium of patients with myomas and menorrhagia.

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  • (PMID = 19014794.001).
  • [ISSN] 1879-0518
  • [Journal-full-title] Contraception
  • [ISO-abbreviation] Contraception
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contraceptives, Oral; 0 / Vascular Endothelial Growth Factor A; 4G7DS2Q64Y / Progesterone; EC 1.14.14.1 / Aromatase; EC 1.14.99.1 / Cyclooxygenase 2
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23. Alborzi S, Ghannadan E, Alborzi S, Alborzi M: A comparison of combined laparoscopic uterine artery ligation and myomectomy versus laparoscopic myomectomy in treatment of symptomatic myoma. Fertil Steril; 2009 Aug;92(2):742-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A comparison of combined laparoscopic uterine artery ligation and myomectomy versus laparoscopic myomectomy in treatment of symptomatic myoma.
  • PATIENT(S): Of 152 women with symptomatic uterine myomas necessitating surgical intervention who wished to retain their uteri, 65 underwent laparoscopic uterine artery ligation and myomectomy (experimental group) and 87 received laparoscopic myomectomy only (control group).
  • In the experimental group, the recurrence of myoma was 6.2%, and 98.1% of the patients reported symptoms improvement; however, in the control group, these figures were 20.75% and 83.1%, respectively (statistically significant).
  • CONCLUSION(S): This study demonstrated the superiority of laparoscopic uterine artery ligation combined with myomectomy in treatment of symptomatic myomas.

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  • (PMID = 18692826.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] United States
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24. Makris N, Vomvolaki E, Mantzaris G, Kalmantis K, Hatzipappas J, Antsaklis A: Role of a bipolar resectoscope in subfertile women with submucous myomas and menstrual disorders. J Obstet Gynaecol Res; 2007 Dec;33(6):849-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of a bipolar resectoscope in subfertile women with submucous myomas and menstrual disorders.
  • METHODS: From January 2000 to December 2005, we studied 59 women of reproductive age with menorrhagia, submucous myomas and one or more infertility factors.
  • Fifteen of the 59 women displayed submucous myoma type O (intracavitary), 34 displayed submucous myoma type I (less than 50% within the myometrium) and the remaining 10 women displayed myoma type II (over 50% being within the myometrium).
  • The mean age and standard deviation of these patients was 34.6 +/- 4.4 years and the average size of myomas was 15 +/- 10 mm.
  • Treatment of these myomas was by hysteroscopic resection using a bipolar resectoscope.
  • The pregnancy rate was notably higher when the sole reason of subfertility was the presence of myoma (54.16%), and when the size of the myoma was equal to 2.5 cm (75%) or more.
  • CONCLUSION: The use of the bipolar resectoscope in hysteroscopic removal of small submucous myomas is shown to be both feasible and effective in controlling menorrhagia and increasing the pregnancy rate in subfertile women, when submucous myomas are the only reason of infertility.

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  • (PMID = 18001453.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Japan
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25. Melli MS, Farzadi L, Madarek EO: Comparison of the effect of gonadotropin-releasing hormone analog (Diphereline) and Cabergoline (Dostinex) treatment on uterine myoma regression. Saudi Med J; 2007 Mar;28(3):445-50
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  • [Title] Comparison of the effect of gonadotropin-releasing hormone analog (Diphereline) and Cabergoline (Dostinex) treatment on uterine myoma regression.
  • OBJECTIVE: To investigate the effect of cabergoline (Dostinex, a dopamine agonist) on the myoma growth compared to Diphereline (a gonadotropin-releasing hormone agonist).
  • Fifty women with uterine myoma, who met the criteria of the study thoroughly, were randomly allocated into 2 equal groups to take either Diphereline or Cabergoline.
  • The tumor regressed significantly and volume reduction rate of individual tumor nodule varied from 46-53%.
  • The gonadotropin releasing hormone agonist group all responded to the treatment, and volume reduction rate of the individual tumor nodule varied from 21-97%.
  • The extent of tumor shrinkage was positively correlated to the number of nodules (p=0.881, p<0.005 and 0.701, p<0.005).
  • [MeSH-minor] Adult. Biopsy, Needle. Dose-Response Relationship, Drug. Drug Administration Schedule. Female. Follow-Up Studies. Humans. Infusions, Intravenous. Middle Aged. Neoplasm Staging. Prospective Studies. Risk Assessment. Treatment Outcome

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  • (PMID = 17334477.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Ergolines; 33515-09-2 / Gonadotropin-Releasing Hormone; LL60K9J05T / cabergoline
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26. Marshburn PB, Matthews ML, Hurst BS: Uterine artery embolization as a treatment option for uterine myomas. Obstet Gynecol Clin North Am; 2006 Mar;33(1):125-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Uterine artery embolization as a treatment option for uterine myomas.
  • A prospective study of "contemporaneous cohorts," which excluded patients who had sub-mucosal and pedunculated subserosal myomas, sought to compare quality of life measures and adverse events in patients who underwent UAE or hysterectomy.
  • Furthermore, hysterectomy eliminates uterine bleeding and the risk for recurrence of myomas.
  • After McLucas advocated that gynecologists learn the skill to perform UAE for managing symptomatic myomas, the Society of Interventional Radiology responded with a precautionary commentary on the level of technical proficiency that is necessary to maintain optimum results from UAE.
  • The gynecologist is likely to be the primary initial consultant to patients who present with complaints of symptomatic myomas.
  • Because some women may experience ovarian failure after UAE, additional studies to determine basal follicle-stimulating hormone and estradiol before and after the procedure may provide insight into UAE-induced follicle depletion.UAE is a unique new treatment for uterine myomas, and is no longer considered investigational for symptomatic uterine fibroids.
  • There is international recognition that data are needed from RCTs that compare UAE with surgical alternatives.
  • FIBROID should provide critical data for the assessment of safety and outcomes measures for women who receive UAE for symptomatic uterine myomas.

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  • (PMID = 16504811.001).
  • [ISSN] 0889-8545
  • [Journal-full-title] Obstetrics and gynecology clinics of North America
  • [ISO-abbreviation] Obstet. Gynecol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 92
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27. Ziadé D, Achkouty R, Mrad R: [Severe hyponatremia associated with transcervical resection of a uterine myoma]. Can J Anaesth; 2009 Apr;56(4):316-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Severe hyponatremia associated with transcervical resection of a uterine myoma].
  • [Transliterated title] Hyponatrémie sévère au cours d'une résection endoscopique d'un myome utérin.
  • CLINICAL FEATURES: A 31-year old female patient underwent transcervical resection of a uterine myoma under general anesthesia.
  • CONCLUSIONS: The resorption syndrome during transcervical resection of a uterine myoma is linked to the passage into the blood of the irrigation fluid that contains glycine.

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  • [CommentIn] Can J Anaesth. 2010 Feb;57(2):181-2 [19904578.001]
  • (PMID = 19252964.001).
  • [ISSN] 0832-610X
  • [Journal-full-title] Canadian journal of anaesthesia = Journal canadien d'anesthésie
  • [ISO-abbreviation] Can J Anaesth
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] TE7660XO1C / Glycine
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28. Bosev D, Dimitrov A: [Changes in uterine myoma dimentions during pregnancy]. Akush Ginekol (Sofiia); 2007;46(5):3-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Changes in uterine myoma dimentions during pregnancy].
  • The purpose of this study is to follow up the changes in the myoma dimentions during pregnancy (1st, 2nd and 3rd trimester).
  • The study is prospective and includes 90 pregnant women with myoma during the period 2002-2006.
  • If more than one myoma was diagnosed, the largest one was considered to be representative.
  • Our data show that the combination of myoma and pregnancy is more frequent with women over the age of 30 and it is more frequent with nullipares (63.2%).
  • Single myomas were more frequent with 58%, 48% of the myomas were intramural and 62% were located in the uterine corpus.
  • Our study shows that during the first trimester there is no change in the myomas dimentions in 35%-43% of the cases and during the second trimester there is no change of the myona dimentions in 50% of the cases.
  • During the third trimester there are only 5% of the myomas that change their dimentions.
  • We conclude, that the myomas, that enlarge during the first trimester, usually enlarge during the second trimester as well.
  • We found no decrease of the myoma dimentions during the third trimester.

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  • (PMID = 17974174.001).
  • [ISSN] 0324-0959
  • [Journal-full-title] Akusherstvo i ginekologii︠a︡
  • [ISO-abbreviation] Akush Ginekol (Sofiia)
  • [Language] bul
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Bulgaria
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29. Demirci F, Somunkiran A, Safak AA, Ozdemir I, Demirci E: Vaginal removal of prolapsed pedunculated submucosal myoma during pregnancy. Adv Ther; 2007 Jul-Aug;24(4):903-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vaginal removal of prolapsed pedunculated submucosal myoma during pregnancy.
  • Pedunculated submucosal myomas are generally associated with infertility and are most often encountered during the preconception period.
  • This report describes a 38-y-old pregnant woman in whom a pedunculated submucosal myoma resulted in preterm labor and was successfully removed vaginally at 26 wk gestation.

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  • (PMID = 17901039.001).
  • [ISSN] 0741-238X
  • [Journal-full-title] Advances in therapy
  • [ISO-abbreviation] Adv Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Miller CE: Unmet therapeutic needs for uterine myomas. J Minim Invasive Gynecol; 2009 Jan-Feb;16(1):11-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unmet therapeutic needs for uterine myomas.
  • Uterine myomas may develop in many women, but only become clinically significant in about one third of the affected population.
  • Although uterine myomas are most often benign, they are associated with debilitating symptoms and commonly result in hysterectomy.
  • Current treatments for uterine myomas include pharmacologic therapies, delivery of focused energy, alteration of uterine vascular supply, or surgical procedures.
  • Factors such as the woman's desire for future pregnancy, the importance of uterine preservation, symptom severity, and tumor characteristics direct the choice of therapeutic approach.
  • The ideal treatment will have the following characteristics: easy to perform, minimally invasive, cost effective, preserves fertility, preserves the uterus, efficacious, acceptable tolerability and durability, and low incidence of myoma recurrence.

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  • (PMID = 19110181.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 110
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31. Practice Committee of American Society for Reproductive Medicine in collaboration with Society of Reproductive Surgeons: Myomas and reproductive function. Fertil Steril; 2008 Nov;90(5 Suppl):S125-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myomas and reproductive function.
  • The purpose of this Educational Bulletin is to examine the relationship between myomas and reproductive function and to review current methods for their management.
  • [MeSH-major] Myoma / physiopathology. Reproduction / physiology. Uterine Neoplasms / physiopathology

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  • (PMID = 19007608.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 33515-09-2 / Gonadotropin-Releasing Hormone
  • [Number-of-references] 72
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32. Lazarov N, Lazarov L, Lazarov S: [Rare form of cervix carcinoma, infiltrating cervical myoma]. Akush Ginekol (Sofiia); 2010;49(3):48-9
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  • [Title] [Rare form of cervix carcinoma, infiltrating cervical myoma].
  • The authors describe rare case of carcinoma colli uteri, which grows to infiltrate submucose cervical myoma.
  • [MeSH-major] Myoma / pathology. Uterine Cervical Neoplasms / pathology

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  • (PMID = 20734657.001).
  • [ISSN] 0324-0959
  • [Journal-full-title] Akusherstvo i ginekologii︠a︡
  • [ISO-abbreviation] Akush Ginekol (Sofiia)
  • [Language] bul
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Bulgaria
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33. Holub Z, Mára M: [Myomas, fertility and pregnancy]. Ceska Gynekol; 2008 Oct;73(5):307-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Myomas, fertility and pregnancy].
  • OBJECTIVE: The objective of this paper is give to guideline to the management of myoma, fertility and pregnancy.


34. Loffer FD: Endometrial ablation in patients with myomas. Curr Opin Obstet Gynecol; 2006 Aug;18(4):391-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endometrial ablation in patients with myomas.
  • PURPOSE OF REVIEW: This review evaluates how the presence of uterine myomas may limit the ability to provide endometrial ablations for patients with menorrhagia, affect subsequent postoperative course and alter long-term outcome.
  • RECENT FINDINGS: New instrumentation and the off-label use of some global ablation techniques allow some selected patients with submucosal myomas to be treated solely by endometrial ablation.
  • The addition of an endometrial ablation in patients undergoing a hysteroscopic myomectomy improves bleeding and their long-term control, but does not decrease the subsequent need for a hysterectomy.
  • Necrosis of intramural myomas is a rare postoperative complication.
  • Untreated myomas may continue to increase in size and lead to a hysterectomy.
  • SUMMARY: The presence of myomas in patients undergoing endometrial ablation may compromise the results and lead to later problems, but most patients can be treated successfully and myomas are not an absolute contraindication.

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  • (PMID = 16794418.001).
  • [ISSN] 1040-872X
  • [Journal-full-title] Current opinion in obstetrics & gynecology
  • [ISO-abbreviation] Curr. Opin. Obstet. Gynecol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 24
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35. Schwartz PE, Kelly MG: Malignant transformation of myomas: myth or reality? Obstet Gynecol Clin North Am; 2006 Mar;33(1):183-98, xii
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant transformation of myomas: myth or reality?
  • The possibility that a fibroid may actually be a smooth muscle tumor of uncertain malignant potential or a leiomyosarcoma often dictates the clinical management of rapidly growing fibroids.
  • The clinician must be aware that the infrequent occurrence of uterine leiomyosarcomas makes it difficult to establish absolutely firm recommendations for the diagnosis and management of this disease, particularly with regard to fertility preservation.
  • Nevertheless, this article addresses major issues that a clinician might face in the evaluation of a smooth muscle tumor of the uterus that clinically may be malignant.

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  • (PMID = 16504815.001).
  • [ISSN] 0889-8545
  • [Journal-full-title] Obstetrics and gynecology clinics of North America
  • [ISO-abbreviation] Obstet. Gynecol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Buyukkurt S, Yuksel A, Seydaoglu G, Has R, Kadayifci O: The effect of amniocentesis on preterm delivery rate in women with uterine myoma. Clin Exp Obstet Gynecol; 2010;37(1):33-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The effect of amniocentesis on preterm delivery rate in women with uterine myoma.
  • OBJECTIVES: To evaluate the effect of genetic amniocentesis on the preterm delivery rate in women with uterine myoma.
  • RESULTS: During the study 14,579 pregnant women were examined and 234 had complications of uterine myomas (1.61%).
  • The results revealed that multifocal fibroids in relation to the myometrium, uterine myoma subjacent to the placenta, total myoma volume greater than 150 cm3 are statistically significant independent risk factors for preterm delivery, while amniocentesis was not found to be an independent risk factor for preterm delivery.
  • CONCLUSIONS: Although having uterine myoma is a fairly known cause of preterm delivery, second trimester genetic amniocentesis does not seem to have any additional adverse effect on the preterm delivery rate in women with uterine myomas.
  • [MeSH-major] Amniocentesis. Myoma / epidemiology. Premature Birth / epidemiology. Uterine Neoplasms / epidemiology

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  • (PMID = 20420278.001).
  • [ISSN] 0390-6663
  • [Journal-full-title] Clinical and experimental obstetrics & gynecology
  • [ISO-abbreviation] Clin Exp Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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37. Ciavattini A, Tsiroglou D, Tranquilli AL, Litta P: Laparoscopic versus ultraminilaparotomic myomectomy for the treatment of large uterine myomas. Acta Obstet Gynecol Scand; 2010;89(1):151-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic versus ultraminilaparotomic myomectomy for the treatment of large uterine myomas.
  • We compared short-term surgical outcomes of laparoscopic and ultraminilaparotomic procedures for the treatment of large uterine myomas in a retrospective matched-control study (Canadian Task Force classification II-2) of 32 women with large myomas who underwent laparoscopic myomectomy and 32 women who had ultraminilaparotomic myomectomy (< or =4 cm incision).
  • Laparoscopic myomectomy seems to be the preferable approach for the treatment of large myomas of > or =5 cm, providing a more rapid recovery compared to the ultraminilaparotomic approach.

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  • (PMID = 19878068.001).
  • [ISSN] 1600-0412
  • [Journal-full-title] Acta obstetricia et gynecologica Scandinavica
  • [ISO-abbreviation] Acta Obstet Gynecol Scand
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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38. Kanaoka Y, Yoshida C, Tsukioka M, Noriyuki M, Ishiko O: Ratio of directly necrotized volume to total volume of a submucosal myoma predicts shrinkage after microwave endometrial ablation. J Obstet Gynaecol Res; 2009 Aug;35(4):717-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ratio of directly necrotized volume to total volume of a submucosal myoma predicts shrinkage after microwave endometrial ablation.
  • AIM: To explore parameters relating to shrinkage of submucosal myomas after microwave endometrial ablation.
  • METHODS: Fourteen patients underwent microwave endometrial ablation at 2.45 GHz using a curved microwave applicator to treat menorrhagia caused by a submucosal myoma.
  • The size of myomas was measured on magnetic resonance images before, one month after, and six months after the operation.
  • The average radius r was defined as half of the size of the myoma measured in three dimensions.
  • The protrusion ratio alpha was defined as the ratio of the thickness of the protruding part of a myoma in the uterine cavity to the size of the myoma before the operation.
  • The ratio of the directly necrotized volume by microwave irradiation to the total volume (RODNeV) of preoperative myomas was calculated using the following formula:.
  • (1) where d is the depth of myoma tissue directly necrotized by microwave irradiation.
  • RESULTS: Two-dimensional plots showing shrinkage of submucosal myomas versus the RODNeV indicated that shrinkage at six months after microwave endometrial ablation depends on the RODNeV.
  • Myomas with a RODNeV greater than 0.17 had shrunk more than 50% at six months after the operation.
  • CONCLUSIONS: RODNeV is closely related to postoperative necrosis and shrinkage of the submucosal myoma after microwave endometrial ablation.
  • Prediction of the shrinkage rate of submucous myomas appears to be possible by calculating the RODNeV preoperatively.

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  • (PMID = 19751333.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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39. Cramer SF, Mann L, Calianese E, Daley J, Williamson K: Association of seedling myomas with myometrial hyperplasia. Hum Pathol; 2009 Feb;40(2):218-25
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  • [Title] Association of seedling myomas with myometrial hyperplasia.
  • Myometrial hyperplasia (MMH) is a common structural variation characterized by irregular zones of increased myometrial cellularity, with increased nucleus-cell ratios; but to date, there has been only anecdotal evidence that it may give rise to myomas.
  • We studied the relationship of seedling myomas to MMH in 50 consecutive hysterectomies and found that most seedling myomas (44/63, 70%) arose in MMH--35 in inframucosal MMH, 3 in subserosal MMH, and 6 from intramural MMH.
  • Some seedling myomas were incompletely circumscribed, seeming to arise not only in but also from MMH.
  • We suggest that even seedlings in normal myometrium may arise not from normal myometrial smooth muscle cells but rather from myometaplasia in intramural stromal emboli, with hyperplastic and then neoplastic transformation.

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  • (PMID = 18799191.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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40. Jindabanjerd K, Taneepanichskul S: The use of levonorgestrel - IUD in the treatment of uterine myoma in Thai women. J Med Assoc Thai; 2006 Oct;89 Suppl 4:S147-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The use of levonorgestrel - IUD in the treatment of uterine myoma in Thai women.
  • OBJECTIVE: This study was designed to evaluate the potential usefulness of the levonorgestrel-releasing intrauterine device (LNG - IUD ; Mirena) in treating women with uterine myomas.
  • SUBJECTS: Sixteen women with uterine myomas who intended to receive treatment with the LNG IUD.
  • MAIN OUTCOME MEASURES: Myoma and Uterine volume, menstrual blood loss assessed with pictorial blood loss assessment charts and hematocrit.
  • RESULTS: Use of the LNG IUD was associated with a statistically significant reduction in the total myoma volume, average uterine size and marked reduction in menstrual blood loss.
  • After 6 months of use, the median total myoma volume decreased from 19.82 mL to 11.63 mL (p < 0.05), median pictorial blood loss assessment chart score declined from 89 to 3 (p < 0.05).
  • CONCLUSION: The LNG IUD was associated with a profound reduction in myoma and uterine volume.
  • For women with myomas of this size, the LNG IUD provides effective medical treatment of bleeding.
  • [MeSH-major] Contraceptives, Oral, Synthetic / therapeutic use. Intrauterine Devices, Medicated. Levonorgestrel / therapeutic use. Myoma / drug therapy. Uterine Neoplasms / drug therapy

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  • (PMID = 17726816.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0 / Contraceptives, Oral, Synthetic; 5W7SIA7YZW / Levonorgestrel
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41. Camanni M, Bonino L, Delpiano EM, Ferrero B, Migliaretti G, Deltetto F: Hysteroscopic management of large symptomatic submucous uterine myomas. J Minim Invasive Gynecol; 2010 Jan-Feb;17(1):59-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hysteroscopic management of large symptomatic submucous uterine myomas.
  • STUDY OBJECTIVE: To evaluate the feasibility of hysteroscopic resection of large submucous uterine myomas.
  • DESIGN: Prospective study (Canadian Task Force classification II-3).
  • PATIENTS: Thirty-three women with submucous myomas 5 cm or larger in diameter with menorrhagia, dysmenorrhea, or infertility.
  • Possibility of 1-step resection; complication rate, and disease recurrence were also considered.
  • According to the Wamsteker classification, 84.8% were type II myomas, whereas 93.9% scored 5 or higher according to the classification of Lasmar and colleagues.
  • Patients with myomas larger than 5 cm or with a Lasmar score higher than 7 were more likely to undergo a 2-step procedure.
  • In patients with myomas larger than 6 cm, recovery time was significantly longer than in those with smaller myomas.
  • CONCLUSIONS: Hysteroscopic myomectomy can be the treatment of choice in symptomatic patients with a submucous myoma with diameter of 6 cm or less.
  • However, for myomas 6 cm or larger in diameter, this approach is less attractive.

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  • [Copyright] Copyright (c) 2010 AAGL. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20129334.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. van Riemsdijk VM, Graziosi GC, Veersema S, Bongers MY: Vaginal myoma expulsion after NovaSure endometrial ablation. J Minim Invasive Gynecol; 2009 Jul-Aug;16(4):496-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vaginal myoma expulsion after NovaSure endometrial ablation.
  • There was a small submucosal type 2 myoma of 2 cm in her normal sized uterus.
  • A myoma of 4 cm was being expelled from the uterus.

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  • (PMID = 19573829.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Redecha M Jr, Holomán K, Javorka V, Mizícková M, Ferianec V, Papcun P, Krizko M Jr, Redecha M Sr: Myoma expulsion after uterine artery embolization. Arch Gynecol Obstet; 2009 Dec;280(6):1023-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myoma expulsion after uterine artery embolization.
  • Uterine artery embolization (UAE) has become a standard therapy in the treatment of symptomatic uterine myomas.
  • One of them is myoma expulsion.
  • A 32-year-old woman was sent to our hospital with diagnosed intramural myoma with dysmenorrhea and pressure symptoms.
  • We diagnosed expulsion of necrotic myoma and performed transvaginal resection.
  • Expulsion of intramural myoma can be thus considered as definite treatment and not a complication of embolization therapy.

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  • (PMID = 19319549.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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44. Fernandez H, Farrugia M, Jones SE, Mauskopf JA, Oppelt P, Subramanian D: Rate, type, and cost of invasive interventions for uterine myomas in Germany, France, and England. J Minim Invasive Gynecol; 2009 Jan-Feb;16(1):40-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rate, type, and cost of invasive interventions for uterine myomas in Germany, France, and England.
  • STUDY OBJECTIVE: The objective of our study was to quantify the rate, type, and cost of interventions for uterine myomas to payers in Germany, France, and England.
  • DESIGN CLASSIFICATION: II-3.
  • PATIENTS: Women admitted for a surgical or radiologic intervention for uterine myomas.
  • INTERVENTIONS: Surgical or radiologic interventions for uterine myomas.
  • MEASUREMENTS AND MAIN RESULTS: We identified the number and type of hospital admissions involving surgical or radiologic interventions for uterine myomas, through the analysis of national hospital activity databases from each country.
  • In 2005, the number (rate) of hospital admissions involving interventions for uterine myomas was 64 299 (1.53/1000 women) in Germany, 37 787 (1.17/1000 women) in France, and 18 274 (0.71/1000 women) in England.
  • The percentage of interventions for uterine myomas that included a hysterectomy was 84.9% in Germany, 59.7% in France, and 64.1% in England.
  • CONCLUSION: The number of admissions and costs associated with interventions for uterine myomas are substantial in the 3 European countries studied.
  • Hysterectomy is the most frequent surgical intervention used to treat uterine myomas.

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  • (PMID = 18996060.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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45. Discepola F, Valenti DA, Reinhold C, Tulandi T: Analysis of arterial blood vessels surrounding the myoma: relevance to myomectomy. Obstet Gynecol; 2007 Dec;110(6):1301-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of arterial blood vessels surrounding the myoma: relevance to myomectomy.
  • Accordingly, we evaluated the location and course of arterial blood vessels surrounding the myoma.
  • RESULTS: We encountered 592 arterial blood vessels surrounding the myoma.
  • The vessels could be seen encircling the surface of the myoma.
  • The dominant myoma was located on anterior (n=30), posterior (n=17), and fundal part of the uterus (n=13).
  • There was no difference in the diameter (6.9+/-2.7 cm, 5.8+/-0.7 cm, and 6.7+/-0.5 cm) and volume of the myoma (268.6+/-52.7 cm(3), 197.0+/-64.5 cm(3), and 199.3+/-40.5 cm(3)) among anterior, posterior, and fundal, respectively.
  • There were significantly more blood vessels in the 30-60 degree group among anterior myoma (n=88, 42.5%) than in 0-30 degree (n=59, 28.5%, P=.004, 95% confidence interval [CI] 0.36-0.81) and 60-90 degree groups (n=60, 29.0%, 95% CI 1.2-2.7).
  • Similar findings were found among posterior myoma (0-30 degrees n=26, 21.7%; 30-60 degrees n=59, 49.2%; P<.001, 95% CI 0.16-0.50; 60-90 degrees 35 (29.2%), P<.002, 95% CI 1.37-3.9).
  • Among fundal myomas, there was no difference in the number of vessels in the 0-30 degree (n=28, 28.6%), 60-90 degree (n=40, 40.8%), and in 60-90 degree groups (n=30, 30.6%).
  • CONCLUSION: Arterial blood vessels travel mostly diagonally on the surface of anterior and posterior myomas.
  • There was no predominant pattern in the course of the arteries on fundal myomas.
  • These findings suggest that regardless of the direction of the myomectomy incision, arterial blood vessels on myoma surface could be injured.

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  • (PMID = 18055724.001).
  • [ISSN] 0029-7844
  • [Journal-full-title] Obstetrics and gynecology
  • [ISO-abbreviation] Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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51. Indman PD: Hysteroscopic treatment of submucous myomas. Clin Obstet Gynecol; 2006 Dec;49(4):811-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hysteroscopic treatment of submucous myomas.
  • Submucous myomas can cause heavy bleeding, pain, and infertility.
  • Classification systems have been developed to help predict the difficulty of resection.

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  • (PMID = 17082675.001).
  • [ISSN] 0009-9201
  • [Journal-full-title] Clinical obstetrics and gynecology
  • [ISO-abbreviation] Clin Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 29
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52. Vitiello D, McCarthy S: Diagnostic imaging of myomas. Obstet Gynecol Clin North Am; 2006 Mar;33(1):85-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic imaging of myomas.
  • As treatment options become less invasive and more sophisticated it is imperative that benign myomas be distinguished from potential malignant conditions without falter.
  • Its usefulness may be enhanced by SHG or transabdominal ultrasound in certain circumstances; however, it falls short in its ability to map multiple myomas or those in large volume uteri.

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  • (PMID = 16504808.001).
  • [ISSN] 0889-8545
  • [Journal-full-title] Obstetrics and gynecology clinics of North America
  • [ISO-abbreviation] Obstet. Gynecol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 35
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53. Xia EL, Duan H, Huang XW, Zheng J, Yu D: [Transcervical resection of myoma in treatment of hysteromyoma, experience in 962 xcases]. Zhonghua Yi Xue Za Zhi; 2005 Jan 19;85(3):173-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Transcervical resection of myoma in treatment of hysteromyoma, experience in 962 xcases].
  • OBJECTIVE: To study the technique and effect of transcervical resection of myoma (TCRM) in treatment of hysteromyoma.
  • METHODS: 962 women suffering type 0 hysteromyoma (n = 281), 316 type 1 hysteromyoma (n = 316), type 2 hysteromyoma (n = 282), submucous and intramural myoma (n = 34), cervical myoma (n = 11), prolapse myoma (n = 23), and adenomyoma (n = 15) underwent TCRM with "five-step technique", monitored by B-ultrasound or laparoscopy, Follow-up lasted more than 6 months.
  • The mean size and depth of uterus were 7.44 +/- 1.3 gestation weeks and (8.31 +/- 1.43) cm, the diameter of the biggest myoma was 7.2 cm.
  • Postoperative scanty menstrual rate was 100% in the type 0 hysteromyoma group, 99.1% in the type I hysteromyoma group, 94.02% in the type II hysteromyoma group, 100% in the cervical myoma and prolapse myoma group, 84% in the multiple myoma and intramural myoma group, and 87% in the adenomyoma group respectively.
  • The residual myoma of 2 cases were resected during the secondary operation 9 days and 3 months after the primary operation.

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  • (PMID = 15854462.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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54. Sinha R, Sundaram M: Laparoscopic management of large myomas. J Gynecol Endosc Surg; 2009 Jul;1(2):73-82

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic management of large myomas.
  • The objective of this article is to review the different techniques that have been adopted for removal of large myomas laparoscopically.
  • We have also quoted literature about the impact of myomas on Pregnancy and obstetrical outcome and the effect of laparoscopic myomectomy on the same.
  • Technical modifications to remove large myomas have been described along with methods to reduce intraoperative bleeding.

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  • (PMID = 22442517.001).
  • [ISSN] 0974-1216
  • [Journal-full-title] Journal of gynecological endoscopy and surgery
  • [ISO-abbreviation] J Gynecol Endosc Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3304276
  • [Keywords] NOTNLM ; Laparoscopic myomectomy / fibroids / large myomas / pregnancy after myomectomy / uterine artery ligation
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55. Mladenović-Mihailović A, Mladenović-Bogdanović Z, Mitrović P, Tanasković I, Usaj-Knezević S, Stanojević M: [Immunocytochemical characteristics of submucosal uterine myomas]. Vojnosanit Pregl; 2010 Dec;67(12):977-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Immunocytochemical characteristics of submucosal uterine myomas].
  • BACKGROUND/AIM: Myomas of the uterus, the most common benign tumors, have been studied for decades from the aspects of different basic and clinical disciplines.
  • The aim of this study was to determine immunocytochemical characteristics of smooth muscle cells and connective tissue components of submucosal myomas of the uterus.
  • METHOD: During the course of this study, 25 samples of submucosal myomas of the uterus were analyzed, all of them obtained during the surgery, after abdominal histerctomy by Aldridge.
  • Sections of 5 microm thickness were stained immunocytochemically using the DAKO LSAB+/HRP technique to identify alpha-smooth muscle actin (alpha-SMA), vimentin, desmin, CD34, CD45, CD68 and PCNA (DAKO specification).
  • RESULTS: Our results suggest that submucosal myomas of the uterus are build-up of smooth muscle cells which are immunoreactive to alpha-SMA and desmin, but also to a certain number of smooth muscle cells which are immunoreactive to alpha-SMA and vimentin.
  • CONCLUSION: Submucosal myomas of the uterus are made-up of smooth muscle cells of the highly differentiated contractile phenotype (alpha-SMA- and desmin-immunoreactivity), as well as smooth muscle cell of the synthetic phenotype which proliferate (alpha-SMA-, vimentin- and PCNA-immunoreactivity).
  • In submucosal myoma of the uterus there is a significant presence of connective tissue as a result of synthetic activity of fibroblasts, which clearly differ in their immunocytochemical characteristics from smooth muscle cells of the synthetic phenotype.
  • [MeSH-minor] Actins / metabolism. Antigens, CD34 / metabolism. Female. Humans. Immunohistochemistry. Intermediate Filament Proteins / metabolism. Muscle, Smooth / metabolism. Muscle, Smooth / pathology. Proliferating Cell Nuclear Antigen / metabolism

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  • (PMID = 21425556.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] srp
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Serbia
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD34; 0 / Intermediate Filament Proteins; 0 / Proliferating Cell Nuclear Antigen
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56. Pailodze MV, Daneliya GS, Dgebuadze MA: Morphofunctional characteristics of the ovaries in proliferative uterine myoma. Bull Exp Biol Med; 2006 Mar;141(3):375-7
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  • [Title] Morphofunctional characteristics of the ovaries in proliferative uterine myoma.
  • Morphofunctional changes in the ovaries in women of reproductive age with proliferative uterine myoma were studied.
  • [MeSH-major] Myoma / pathology. Ovary / pathology. Uterine Neoplasms / pathology

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  • (PMID = 17073164.001).
  • [ISSN] 0007-4888
  • [Journal-full-title] Bulletin of experimental biology and medicine
  • [ISO-abbreviation] Bull. Exp. Biol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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57. Bukulmez O, Doody KJ: Clinical features of myomas. Obstet Gynecol Clin North Am; 2006 Mar;33(1):69-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical features of myomas.
  • Uterine myomas are the most common solid pelvic tumors in women and the primary indication for hysterectomy.
  • Most of the myomas are asymptomatic.
  • The most common symptoms associated with uterine myomas are abnormal uterine bleeding and pelvic discomfort mostly caused by the mass effect.
  • Uterine myomas have a significant role in reproductive dysfunction, although a causal relationship between infertility and intramural or subserosal myomas not disturbing the uterine cavity has not been established clearly.
  • Nevertheless myomas, especially the tumors distorting the uterine cavity, are associated with infertility and spontaneous miscarriage.
  • In addition, the myomas may be the potential cause for numerous obstetric complications, especially if they are located adjacent to placenta.
  • The transformation of myomas to leiomyosarcomas is a very rare event.
  • Despite the high prevalence of these tumors, there is paucity of data available regarding the natural clinical history of myomas.

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  • (PMID = 16504807.001).
  • [ISSN] 0889-8545
  • [Journal-full-title] Obstetrics and gynecology clinics of North America
  • [ISO-abbreviation] Obstet. Gynecol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 74
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58. Schweppe KW: Long-term use of progestogens--effects on endometriosis, adenomyosis and myomas. Gynecol Endocrinol; 2007 Oct;23 Suppl 1:17-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term use of progestogens--effects on endometriosis, adenomyosis and myomas.
  • Oral progestins, without an estrogen component, have been reported to be effective in the treatment of endometriosis, but not adenomyosis or myomas.
  • Besides the importance of estrogens for the development and growth of endometriosis and myomas, progesterone seems to play an important role in the modulation of mitotic activity, local growth factors and growth factor receptors, as well as other paracrine mechanisms.
  • Effective new therapies for endometriosis have been introduced during the last 30 years and progestins now have a place in the symptomatic management of pain, bleeding and other symptoms caused by endometriosis, adenomyosis or myoma, particularly when long-term medication is indicated or when repeated courses of treatment are acceptable.
  • [MeSH-major] Endometriosis / drug therapy. Myoma / drug therapy. Progestins / administration & dosage

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  • (PMID = 17943535.001).
  • [ISSN] 1473-0766
  • [Journal-full-title] Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • [ISO-abbreviation] Gynecol. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Progestins
  • [Number-of-references] 33
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59. Ferrero S, Abbamonte LH, Giordano M, Parisi M, Ragni N, Remorgida V: Uterine myomas, dyspareunia, and sexual function. Fertil Steril; 2006 Nov;86(5):1504-10
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  • [Title] Uterine myomas, dyspareunia, and sexual function.
  • OBJECTIVE: To determine the prevalence of deep dyspareunia (DD) and characteristics of sexual life in women with uterine myomas.
  • PATIENT(S): Three hundred seven sexually active premenopausal women who underwent surgery because of uterine myomas (group M, n = 132), uterine myomas and ovarian cysts (group MC, n = 84), ovarian cysts (group C, n = 67), and tubal sterilization (group S, n = 24).
  • Exclusion criteria were as follows: endometriosis, pelvic inflammatory disease, interstitial cystitis, and preoperative treatment with GnRH analogues.
  • INTERVENTION(S): Before surgery, patients underwent transvaginal ultrasound; number and characteristics of myomas were recorded.
  • No significant difference was observed in DD prevalence and pain intensity according to the number, position, and size of myomas.
  • Deep dyspareunia intensity was higher in women with fundal and anterior myomas than in those with other myoma positions.
  • CONCLUSION(S): Women with uterine myomas do not have increased prevalence or severity of DD; their sexual function is not impaired.


60. Paul PG, Koshy AK: Multiple peritoneal parasitic myomas after laparoscopic myomectomy and morcellation. Fertil Steril; 2006 Feb;85(2):492-3

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  • [Title] Multiple peritoneal parasitic myomas after laparoscopic myomectomy and morcellation.
  • We describe multiple parasitic myomas visualized on laparoscopy in a woman who had a previous laparoscopic myomectomy.
  • Location of the myomas suggests morcellation as a contributing factor.
  • [MeSH-major] Laparoscopy / adverse effects. Myoma / pathology. Myoma / surgery. Peritoneal Neoplasms / pathology. Peritoneal Neoplasms / surgery

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  • (PMID = 16595233.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Kebaili S, Dhouib M, Chaabane K, Chtioui A, Amouri H, Ben Ayed B, Guermazi M: [Exploration of post-menopausal uterine bleeding. Hysteroscopy-histology correlation in 94 cases]. Sante; 2010 Apr-Jun;20(2):99-104
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  • [Transliterated title] Exploration des métrorragies postménopausiques par hystéroscopie : à propos de 94 cas.
  • Because the cause may be a malignant disease, a thorough work-up is necessary to attempt to identify an organic cause.
  • RESULTS: By hysteroscopy, we observed atrophic uterine linings in 53 patients (56%), endometrial polyps in 43 patients (45%), endometrial hyperplasia in 23 patients (24%) and myomas in 24 patients (25.5%).
  • [MeSH-major] Genital Diseases, Female / blood. Hysteroscopy / methods. Postmenopause. Uterine Hemorrhage / pathology. Uterine Neoplasms / pathology
  • [MeSH-minor] Atrophy. Endometrium / pathology. Female. Humans. Hyperplasia / pathology. Middle Aged. Myxoma / pathology. Polyps / pathology. Uterine Cervical Diseases / pathology. Uterus / pathology

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  • (PMID = 20688595.001).
  • [ISSN] 1157-5999
  • [Journal-full-title] Santé (Montrouge, France)
  • [ISO-abbreviation] Sante
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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62. Kajo K, Zúbor P, Krivus S, Danko J: [Angiolipoleiomyoma of the uterus. Case report and literature review]. Ceska Gynekol; 2010 Feb;75(1):54-6
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  • CONCLUSION: The ALLM of the uterus is rare benign mixed mesenchyme tumor consisting of smooth muscle bundles, foci of mature fat tissue and abnormal vessels.
  • The presented case is describing a 53-year-old women hysterectomized for multiple uterine myoma of which two showed the histological signs of ALLM.

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  • (PMID = 20437838.001).
  • [ISSN] 1210-7832
  • [Journal-full-title] Ceska gynekologie
  • [ISO-abbreviation] Ceska Gynekol
  • [Language] SLO
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Czech Republic
  • [Number-of-references] 18
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63. Agdi M, Tulandi T: Minimally invasive approach for myomectomy. Semin Reprod Med; 2010 May;28(3):228-34
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  • Uterine fibroids are the most common benign tumor of the uterus in women of reproductive age.
  • Submucous myoma should be treated by a hysteroscopic approach.
  • Intramural and subserous myomas in women who opt for nonsurgical treatment could be treated with uterine artery embolization (UAE), high-intensity focused ultrasound (HIFU), or medical treatment such as selective gonadotropin-releasing hormone agonists, progesterone receptor modulators, or aromatase inhibitors.

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  • [Copyright] Thieme Medical Publishers.
  • (PMID = 20414845.001).
  • [ISSN] 1526-4564
  • [Journal-full-title] Seminars in reproductive medicine
  • [ISO-abbreviation] Semin. Reprod. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 58
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64. Lee CL, Wang CJ: Laparoscopic myomectomy. Taiwan J Obstet Gynecol; 2009 Dec;48(4):335-41
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  • LM procedures include excision of the myoma(s), repair of myometrium, and removal of the myoma from the abdomen.

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  • [CommentIn] Taiwan J Obstet Gynecol. 2010 Sep;49(3):392-3 [21056336.001]
  • (PMID = 20045753.001).
  • [ISSN] 1875-6263
  • [Journal-full-title] Taiwanese journal of obstetrics & gynecology
  • [ISO-abbreviation] Taiwan J Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 49
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65. Solè LI, Rosato G, Bolino MC, Bassotti G: An unusual cause of obstructed defecation. Tech Coloproctol; 2009 Sep;13(3):247-9
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  • Obstructed defecation is one subtype of constipation, and may be due to functional or mechanical causes.
  • Here, we report an unusual cause, never described before, of obstructed defecation due to a large uterine myoma that reverted to normal bowel habits after surgery.
  • [MeSH-minor] Chronic Disease. Constipation / diagnosis. Constipation / etiology. Defecation / physiology. Female. Follow-Up Studies. Humans. Hysterectomy / methods. Magnetic Resonance Spectroscopy. Manometry / methods. Middle Aged. Recovery of Function. Risk Assessment. Severity of Illness Index. Treatment Outcome

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  • [Cites] Br J Surg. 1997 Nov;84(11):1555-8 [9393278.001]
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  • (PMID = 19609740.001).
  • [ISSN] 1128-045X
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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66. Eisinger SH, Fiscella J, Bonfiglio T, Meldrum S, Fiscella K: Open-label study of ultra low-dose mifepristone for the treatment of uterine leiomyomata. Eur J Obstet Gynecol Reprod Biol; 2009 Oct;146(2):215-8
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  • STUDY DESIGN: Open-label cohort study of 2.5mg mifepristone orally among adult women with at least moderately severe symptoms related to leiomyomata and total uterine volume of greater than 160 cm(3), or at least one myoma of greater than 2.5 cm diameter.

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  • (PMID = 19586708.001).
  • [ISSN] 1872-7654
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Hormone Antagonists; 320T6RNW1F / Mifepristone
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67. Takeda A, Koyama K, Imoto S, Mori M, Sakai K, Nakamura H: Progressive formation of uterine arteriovenous fistula after laparoscopic-assisted myomectomy. Arch Gynecol Obstet; 2009 Oct;280(4):663-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CASE REPORT: A 39-year-old nulligravida underwent LAM for multiple myomas.
  • Early diagnosis and endovascular management can provide a significant benefit for a woman wishing uterine preservation.

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  • (PMID = 19224230.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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68. Wang HQ, Lü G, Shi ZZ, Zhu D: [Study on the pathological uterine tissues with a fiber Raman spectrometry]. Guang Pu Xue Yu Guang Pu Fen Xi; 2008 Oct;28(10):2338-42
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  • The Raman spectrum can reflect the differences in chemical components and molecular structures of tissues and cells, and significant progress has been made in the research on structures, functions and diseases of cells and tissues with Raman spectroscopy.
  • A fiber Raman spectrometer was used to measure the Raman spectra of some uterine malignant, benign, and normal tissues, such as uterine myometrium tissue, uterine myoma tissue, normal endometrium tissue, malignant endometrium tissue and adenomyosis tissue.
  • After having compared the Raman spectrum of pathological tissues with that of the corresponding normal tissues, we observed that the peak referring to Methionine upsilon(C--S) (Met upsilon(C--S)) splits into two peaks in the uterine myoma tissues caused by the vibrations of tryptophan (Trp) and cartotene, which are not present in the normal tissues.
  • This study is not only helpful on early diagnosis of uterine diseases, but also very crucial for the basic research on uterine diseases.

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  • (PMID = 19123402.001).
  • [ISSN] 1000-0593
  • [Journal-full-title] Guang pu xue yu guang pu fen xi = Guang pu
  • [ISO-abbreviation] Guang Pu Xue Yu Guang Pu Fen Xi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 36-88-4 / Carotenoids; 8DUH1N11BX / Tryptophan
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69. Lin CC, Ou MC, Hsiao SM, Lin HH: Myomectomy through the uterine cervix using forceps under sonographic guidance. Ultrasound Obstet Gynecol; 2009 Feb;33(2):228-31
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  • METHODS: Between June 2005 and August 2006, we performed a prospective study to evaluate the feasibility of forceps myomectomy under sonographic guidance in patients with submucosal myomas.
  • Patients were enrolled into the study if, on transvaginal sonographic or hysteroscopic examination, their myomas were found to have an intramural extension < 75%, absence of 'sinking' and a mean diameter < 8 cm.
  • RESULTS: There were 28 patients with submucosal myomas including Types 0 (n = 18), 1 (n = 6) and 2 (n = 4).
  • In 26/28 (92.8%; 95% CI, 82.6-100) patients the myomas were removed completely.
  • CONCLUSIONS: In our experience, this novel method of forceps myomectomy is feasible for the removal of Type 0 and Type 1 submucosal myomas as well as selected Type 2 myomas.

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  • (PMID = 19053164.001).
  • [ISSN] 1469-0705
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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70. Serocki G, Hanss R, Bauer M, Scholz J, Bein B: [The gynecological TURP syndrome. Severe hyponatremia and pulmonary edema during hysteroscopy]. Anaesthesist; 2009 Jan;58(1):30-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A case report is presented of a 44-year-old woman scheduled for operative hysteroscopy for intracavital myoma under general anaesthesia, suffering from severe absorption syndrome leading to hyponatremia of 106 mEq/l and pulmonary edema necessitating subsequent admission to ICU.
  • [MeSH-minor] Adult. Anesthesia, General. Blood Gas Analysis. Critical Care. Female. Genital Neoplasms, Female / complications. Genital Neoplasms, Female / diagnosis. Humans. Hypotonic Solutions / adverse effects. Male. Myoma / complications. Myoma / diagnosis

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  • (PMID = 18853124.001).
  • [ISSN] 1432-055X
  • [Journal-full-title] Der Anaesthesist
  • [ISO-abbreviation] Anaesthesist
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Hypotonic Solutions
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71. Revaux A, Ducarme G, Luton D: [Prevention of intrauterine adhesions after hysteroscopic surgery]. Gynecol Obstet Fertil; 2008 Mar;36(3):311-7
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  • The prevalence of intrauterine adhesions after hysteroscopic surgery is correlated to intrauterine pathology (myoma, polyp, or adhesions).

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  • (PMID = 18308609.001).
  • [ISSN] 1297-9589
  • [Journal-full-title] Gynécologie, obstétrique & fertilité
  • [ISO-abbreviation] Gynecol Obstet Fertil
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Cellulose, Oxidized; 0 / Membranes, Artificial; 9002-84-0 / Polytetrafluoroethylene; 9004-61-9 / Hyaluronic Acid
  • [Number-of-references] 55
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72. Meshkova IE, Volkova AV, Semenov II: [Features of ultrasound diagnosis of non-epithelial ovarian carcinoma]. Vopr Onkol; 2007;53(3):345-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ultrasound examination using color Doppler imaging was used in 70 patients with non-epithelial ovarian carcinoma and 23 patients with subserous nodes of uterine myoma.
  • The procedure can be used for differentiated diagnosis between non-epithelial ovarian carcinoma and subserous nodes of uterine myoma, as well as for appraisal of individual features of tumor so that adequate treatment might be selected.
  • [MeSH-major] Myoma / ultrasonography. Ovarian Neoplasms / ultrasonography

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  • (PMID = 18198619.001).
  • [ISSN] 0507-3758
  • [Journal-full-title] Voprosy onkologii
  • [ISO-abbreviation] Vopr Onkol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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73. Fujita T, Hayashi K, Katanoda K, Matsumura Y, Lee JS, Takagi H, Suzuki S, Mizunuma H, Aso T: Prevalence of diseases and statistical power of the Japan Nurses' Health Study. Ind Health; 2007 Oct;45(5):687-94
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  • [Title] Prevalence of diseases and statistical power of the Japan Nurses' Health Study.
  • Based on currently limited statistical data regarding the incidence of disease among Japanese women, our initial sample size was tentatively set at 50,000 during the design phase.
  • Taking into account the actual sample size and new information on disease frequency obtained during the baseline component, we established the prevalence of past diagnoses of target diseases, predicted their incidence, and calculated the statistical power for JNHS follow-up surveys.
  • For all diseases except ovarian cancer, the prevalence of a past diagnosis increased markedly with age, and incidence rates could be predicted based on the degree of increase in prevalence between two adjacent 5-yr age groups.
  • The predicted incidence rate for uterine myoma, hypercholesterolemia, and hypertension was > or =3.0 (per 1,000 women, per year), while the rate of thyroid disease, hepatitis, gallstone disease, and benign breast tumor was predicted to be > or =1.0.
  • For these diseases, the statistical power to detect risk factors with a relative risk of 1.5 or more within ten years, was 70% or higher.
  • [MeSH-major] Attitude to Health. Health Behavior. Health Status. Nursing. Nursing Staff. Occupational Diseases / epidemiology. Occupational Health

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  • (PMID = 18057812.001).
  • [ISSN] 0019-8366
  • [Journal-full-title] Industrial health
  • [ISO-abbreviation] Ind Health
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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74. Hurst BS, Elliot M, Matthews ML, Marshburn PB: Ultrasound-directed transvaginal myolysis: preclinical studies. J Minim Invasive Gynecol; 2007 Jul-Aug;14(4):502-5
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  • The ultimate goal is to develop a safe vaginal ultrasound-directed myolysis needle to treat uterine myomas.
  • The specific preclinical study objective was to determine the optimal power to coagulate myomas in hysterectomy specimens with a prototype needle in a prospective preclinical study with an echogenic insulated needle electrode.
  • Ultrasound-directed transvaginal myolysis may provide another option for women with uterine myomas if it is proven safe and effective in future clinical studies.

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  • (PMID = 17630171.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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75. Maia H Jr, Pimentel K, Casoy J, Correia T, Freitas LA, Zausner B, Athayde C, Coutinho E: Aromatase expression in the eutopic endometrium of myomatous uteri: the influence of the menstrual cycle and oral contraceptive use. Gynecol Endocrinol; 2007 Jun;23(6):320-4
MedlinePlus Health Information. consumer health - Uterine Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIMS: To detect aromatase expression in the endometrium of myomatous uteri and to correlate it with the location of the myoma, phase of the menstrual cycle, the presence of menorrhagia and oral contraceptive use.
  • Sixty-one patients had menorrhagia associated with intramural/submucous myomas and nine had subserous myomas and no excessive bleeding.
  • RESULTS: Aromatase p450 expression was detected more frequently in the eutopic endometrium of patients with submucous or intramural myomas than in those in the subserous group, and was significantly greater during the proliferative phase than during the luteal phase or following the use of oral contraceptives.
  • CONCLUSIONS: Aromatase expression in the endometrium was affected by the location of the myoma, the presence of symptoms, and the phase of the menstrual cycle.
  • Oral contraceptives, on the other hand, inhibited aromatase expression in the eutopic endometrium of patients with submucous/intramural myomas.

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  • (PMID = 17616855.001).
  • [ISSN] 0951-3590
  • [Journal-full-title] Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • [ISO-abbreviation] Gynecol. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contraceptives, Oral; EC 1.14.14.1 / Aromatase
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81. Hanstede MM, Tempany CM, Stewart EA: Focused ultrasound surgery of intramural leiomyomas may facilitate fertility: a case report. Fertil Steril; 2007 Aug;88(2):497.e5-7
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  • INTERVENTION: Magnetic resonance imaging-guided focused ultrasound surgery treatment of two intramural myomas, one with a significant submucosal component.

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  • (PMID = 17292361.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. Bakour SH, Jones SE, O'Donovan P: Ambulatory hysteroscopy: evidence-based guide to diagnosis and therapy. Best Pract Res Clin Obstet Gynaecol; 2006 Dec;20(6):953-75
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  • There is a general consensus that hysteroscopy is the current gold standard for evaluating intrauterine pathology, including submucous myomas, polyps, hyperplasia and cancer.
  • [MeSH-major] Genital Diseases, Female. Hysteroscopy. Pregnancy Complications

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  • (PMID = 17116420.001).
  • [ISSN] 1521-6934
  • [Journal-full-title] Best practice & research. Clinical obstetrics & gynaecology
  • [ISO-abbreviation] Best Pract Res Clin Obstet Gynaecol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 45
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83. Kapranov SA, Bobrov BIu: [Effect of technical and anatomical factors on efficacy of embolization of uterine arteries]. Angiol Sosud Khir; 2006;12(2):51-6
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  • The article deals with analysis of technical and anatomical factors influencing the efficacy of uterine arteries embolization (UAE) in treatment of patients with uterine myoma.
  • 3) an adventitious restoration of blood supply to the uterine myoma.

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  • (PMID = 17053762.001).
  • [ISSN] 1027-6661
  • [Journal-full-title] Angiologii︠a︡ i sosudistai︠a︡ khirurgii︠a︡ = Angiology and vascular surgery
  • [ISO-abbreviation] Angiol Sosud Khir
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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84. Kwon YI, Kim TH, Sohn JW, Yoon HJ, Shin DH, Park SS: Benign pulmonary metastasizing leiomvomatosis: case report and a review of the literature. Korean J Intern Med; 2006 Sep;21(3):173-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign pulmonary metastasizing leiomvomatosis: case report and a review of the literature.
  • She had undergone hysterectomy 16 years previously for uterine myoma.
  • An open lung biopsy revealed tumor that was composed of interlacing bundles of spindle cells with cigar shaped nucleus and eosinophilic myofibrils in the cytoplasm; consistent with multiple leiomyomas.
  • We report here on an interesting case of benign metastasizing leiomyoma (BML) in 51-year-old patient.
  • [MeSH-minor] Disease Progression. Female. Humans. Hysterectomy. Middle Aged. Ovariectomy

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  • [Cites] Hum Pathol. 2000 Jan;31(1):126-8 [10665925.001]
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  • (PMID = 17017666.001).
  • [ISSN] 1226-3303
  • [Journal-full-title] The Korean journal of internal medicine
  • [ISO-abbreviation] Korean J. Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Korea (South)
  • [Number-of-references] 18
  • [Other-IDs] NLM/ PMC3890720
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85. Sabbah R, Desaulniers G: Use of the NovaSure Impedance Controlled Endometrial Ablation System in patients with intracavitary disease: 12-month follow-up results of a prospective, single-arm clinical study. J Minim Invasive Gynecol; 2006 Sep-Oct;13(5):467-71
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  • [Title] Use of the NovaSure Impedance Controlled Endometrial Ablation System in patients with intracavitary disease: 12-month follow-up results of a prospective, single-arm clinical study.
  • STUDY OBJECTIVE: To assess the safety and effectiveness of the NovaSure Impedance Controlled Endometrial Ablation System for the treatment of excessive uterine bleeding in premenopausal and postmenopausal women with intracavitary disease (polyps or myomas) up to 3 cm.
  • DESIGN: Prospective, single-arm study. (Canadian Task Force Classification II-2.
  • PATIENTS: This clinical study was conducted in 65 women with menometrorrhagia with confirmed (type I and II) submucous myomas up to 3 cm with and without polyps.
  • MEASUREMENTS AND MAIN RESULTS: All patients were diagnosed with intracavitary disease during office hysteroscopy.
  • CONCLUSION: Clinical results of this study demonstrate that the NovaSure System is safe and effective in treatment of patients with menometrorrhagia caused by intracavitary disease up to 3 cm.

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  • (PMID = 16962534.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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86. Fambrini M, Penna C, Pieralli A, Andersson KL, Zambelli V, Scarselli G, Marchionni M: Feasibility of myomectomy performed by minilaparotomy. Acta Obstet Gynecol Scand; 2006;85(9):1109-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: All patients submitted to laparotomic conservative surgery for uterine myomas through an initial minilaparotomic approach (4-8-cm transverse skin incision) were retrospectively evaluated.
  • In 97 (57.1%) multiple myomas were present (maximum, 23).
  • The size of the largest myoma ranged from 2 to 19 cm (median 5.6).

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  • (PMID = 16929417.001).
  • [ISSN] 0001-6349
  • [Journal-full-title] Acta obstetricia et gynecologica Scandinavica
  • [ISO-abbreviation] Acta Obstet Gynecol Scand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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87. Dueholm M: Transvaginal ultrasound for diagnosis of adenomyosis: a review. Best Pract Res Clin Obstet Gynaecol; 2006 Aug;20(4):569-82
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  • The diagnostic accuracy of TVS is at an intermediate level but is in line with that of magnetic resonance imaging (MRI) in unselected patients without myomas undergoing surgery.
  • TVS is a sufficiently accurate tool for diagnosis of adenomyosis in clinically suspected cases, but not in unselected premenopausal women with myomas.
  • [MeSH-major] Endometriosis / ultrasonography. Uterine Diseases / ultrasonography
  • [MeSH-minor] Biopsy, Needle. Endometrium / pathology. Endometrium / ultrasonography. Female. Humans. Hysteroscopy. Magnetic Resonance Imaging. Myoma / ultrasonography. Myometrium / pathology. Observer Variation. Postmenopause. Premenopause. Reproducibility of Results. Sensitivity and Specificity. Uterine Neoplasms / ultrasonography

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  • (PMID = 16545618.001).
  • [ISSN] 1521-6934
  • [Journal-full-title] Best practice & research. Clinical obstetrics & gynaecology
  • [ISO-abbreviation] Best Pract Res Clin Obstet Gynaecol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 81
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88. Zúbor P, Szunyogh N, Galo S, Biringer K, Dókus K, Visnovský J, Danko J: [Laparoscopy in chronic pelvic pain--a prospective clinical study]. Ceska Gynekol; 2005 May;70(3):225-31
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  • The most frequent finding was endometriosis (31.4%).
  • Pelvic adhesions, myomas, pelvic varicosities and chronic inflammatory process were present in 25.6, 15.1, 9.3 and 3.5% of the cases, respectively.
  • Our combined effort should stop the progression of such pathology leading to possible morphologic, functional and psychological alteration, especially among young women in fertile age.

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  • (PMID = 16047928.001).
  • [ISSN] 1210-7832
  • [Journal-full-title] Ceska gynekologie
  • [ISO-abbreviation] Ceska Gynekol
  • [Language] SLO
  • [Publication-type] Clinical Trial; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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89. Krikun G, Mor G, Huang J, Schatz F, Lockwood CJ: Metalloproteinase expression by control and telomerase immortalized human endometrial endothelial cells. Histol Histopathol; 2005 07;20(3):719-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Indeed many pathological conditions causing abnormal endometrial bleeding including progestin only contraception, hormone replacement therapy, endometrial polyps, myomas, hyperplasia and cancer are associated with aberrant angiogenesis.

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  • (PMID = 15944920.001).
  • [ISSN] 0213-3911
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / R01 HD 33937-06; United States / NHLBI NIH HHS / HL / R01 HL 70004-01A1
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Tissue Inhibitor of Metalloproteinase-1; 127497-59-0 / Tissue Inhibitor of Metalloproteinase-2; EC 2.7.7.49 / Telomerase; EC 3.4.- / Metalloproteases
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90. Litta P, Merlin F, Saccardi C, Pozzan C, Sacco G, Fracas M, Capobianco G, Dessole S: Role of hysteroscopy with endometrial biopsy to rule out endometrial cancer in postmenopausal women with abnormal uterine bleeding. Maturitas; 2005 Feb 14;50(2):117-23
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  • RESULTS: Histological findings for <4 mm level revealed that atrophy was present in 48 (65%) and in 2 cases (2.7%) endometrial cancer was found; for > or = 4 mm values polyps and myomas were present in 86 (59%) and there were 11 (7.5%) endometrial cancer.
  • CONCLUSIONS: In conclusion, endometrial thickness <4 mm can miss malignancies but trans-vaginal ultrasound remains the first line diagnostic procedure in postmenopausal women without AUB, because it is not invasive and has high sensitivity for detecting endometrial cancer and other endometrial disease; according to our experience, outpatient hysteroscopy with biopsy is mandatory in all postmenopausal women with AUB.

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  • (PMID = 15653009.001).
  • [ISSN] 0378-5122
  • [Journal-full-title] Maturitas
  • [ISO-abbreviation] Maturitas
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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91. Ferrero S, Bentivoglio G: Adenomyosis in a patient with mosaic Turner's syndrome. Arch Gynecol Obstet; 2005 Mar;271(3):249-50
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  • At transabdominal ultrasound a myoma (15 x 8.5 x 8 cm) arising from the posterior uterine wall was suspected.
  • Histologic examination confirmed the presence of the myoma and revealed the presence of focal adenomyosis.

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  • (PMID = 15014950.001).
  • [ISSN] 0932-0067
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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92. Duhan N, Sirohiwal D: Uterine myomas revisited. Eur J Obstet Gynecol Reprod Biol; 2010 Oct;152(2):119-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Uterine myomas revisited.
  • The present study was planned to review the pathophysiology of uterine myomas and emphasize the principles of logical management on the basis of literature review and synthesis of the author's experience.
  • The growth of uterine myomas, the most common solid pelvic tumors in women, is related to genetic predisposition, hormonal influences and growth factors.
  • Most asymptomatic myomas can be followed serially for progressive growth or development of symptoms.

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  • [Copyright] Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20933150.001).
  • [ISSN] 1872-7654
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
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93. Dane B, Dane C, Basaran S, Erginbas M, Cetin A: Vaginal Schwannoma in a case with uterine myoma. Ann Diagn Pathol; 2010 Apr;14(2):137-9
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  • [Title] Vaginal Schwannoma in a case with uterine myoma.
  • We report a case of vaginal schwannoma associated with uterine myoma.
  • A 52-year-old woman presented with lower abdominal pain and menorrhagia for a duration of 6 months.
  • At sonographic examination, the patient was found to have uterine myomas and a solid mass measuring 5x4.5 cm beneath the vaginal wall.
  • At laparotomy, the uterus with myoma was removed using our standard operation procedures.
  • The tumor cells were vimentin (+), desmin (-), smooth muscle alpha-actin (-), HMB-45 (-), MART-1 (-) and S-100 (+).
  • Immunocytochemical labeling of the tumor cells is essential.

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20227020.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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94. Prapas Y, Kalogiannidis I, Prapas N: Laparoscopy vs laparoscopically assisted myomectomy in the management of uterine myomas: a prospective study. Am J Obstet Gynecol; 2009 Feb;200(2):144.e1-6
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  • [Title] Laparoscopy vs laparoscopically assisted myomectomy in the management of uterine myomas: a prospective study.
  • Laparoscopic (n = 40) vs laparoscopically assisted myomectomy (n = 76) were compared for the management of no more than 3 intramural or subserous uterine myomas, of a maximum diameter of 90 mm.
  • RESULTS: The patients' characteristics by age, parity, body mass index, number and location of myomas were well balanced between the 2 study groups.
  • The mean diameter of the myomas was the only characteristic significantly higher in the laparoscopically assisted myomectomy group.

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  • (PMID = 19019334.001).
  • [ISSN] 1097-6868
  • [Journal-full-title] American journal of obstetrics and gynecology
  • [ISO-abbreviation] Am. J. Obstet. Gynecol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] United States
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95. Funaki K, Fukunishi H, Funaki T, Kawakami C: Mid-term outcome of magnetic resonance-guided focused ultrasound surgery for uterine myomas: from six to twelve months after volume reduction. J Minim Invasive Gynecol; 2007 Sep-Oct;14(5):616-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mid-term outcome of magnetic resonance-guided focused ultrasound surgery for uterine myomas: from six to twelve months after volume reduction.
  • STUDY OBJECTIVE: To clarify the volume change ratio of uterine myomas treated with magnetic resonance-guided focused ultrasound surgery (MRgFUS), in relation to the signal intensity of T(2)-weighted magnetic resonance (MR) images.
  • DESIGN: Prospective study (Canadian Task Force classification II-3).
  • PATIENTS: Forty-eight myomas in 35 patients were followed up with MR images 6 months after MRgFUS, and 23 myomas in 17 patients were followed up 12 months after MRgFUS.
  • Before treatment, the myomas were classified into 3 types on the basis of the signal intensity of T(2)-weighted MR images as follows: Type 1, low intensity; type 2, intermediate intensity; type 3, high intensity.
  • MEASUREMENTS AND MAIN RESULTS: MRgFUS produced a greater volume reduction in type 1 and type 2 myomas than in type 3 myomas.
  • Nonperfused areas always diminished in the period after MRgFUS; however, the volume change was affected by the volume change ratio of perfused areas inside the treated myomas.
  • CONCLUSION: At present, type 3 myomas should be exempted from the application of MRgFUS, because the nonperfused ratio immediately after the procedure was small compared with that in type 1 and type 2 myomas, and the subsequent volume change was unfavorable.

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  • (PMID = 17848324.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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96. Liu WM, Wang PH, Chou CS, Tang WL, Wang IT, Tzeng CR: Efficacy of combined laparoscopic uterine artery occlusion and myomectomy via minilaparotomy in the treatment of recurrent uterine myomas. Fertil Steril; 2007 Feb;87(2):356-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Efficacy of combined laparoscopic uterine artery occlusion and myomectomy via minilaparotomy in the treatment of recurrent uterine myomas.
  • OBJECTIVE: To evaluate the therapeutic efficacy of laparoscopic uterine artery occlusion combined with myomectomy through a minilaparotomy in the treatment of recurrent uterine myomas, compared with myomectomy alone.
  • PATIENT(S): Eighty-two women with symptomatic, recurrent myomas warranting surgical treatment, who expressed a strong desire to retain their uterus.
  • MAIN OUTCOME MEASURE(S): The efficacy of combined laparoscopic uterine artery occlusion and myomectomy via minilaparotomy in the treatment of recurrent uterine myomas was measured by comparing blood loss, need for blood transfusion, postoperative febrile morbidity, recurrence rate of the uterine myomas, and fertility rate in the treatment (group I) and control (group II) groups.
  • The recurrence rate of uterine myomas was 5.8% (3 of 52) in group I and 36.7% (11 of 30) in group II during an average follow-up period of 42.5 months.
  • CONCLUSION(S): This study has demonstrated the superiority of laparoscopic uterine artery occlusion when combined with repeat myomectomy in treating recurrent symptomatic myomas.
  • [MeSH-major] Laparoscopy / methods. Laparotomy / methods. Leiomyoma / surgery. Neoplasm Recurrence, Local / surgery. Uterine Neoplasms / surgery. Uterus / blood supply. Uterus / surgery

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  • [CommentIn] Fertil Steril. 2007 Sep;88(3):758-9; author reply 759 [17681320.001]
  • (PMID = 17069812.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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97. Vilos GA, Vilos AG, Abu-Rafea B, Pron G, Kozak R, Garvin G: Administration of goserelin acetate after uterine artery embolization does not change the reduction rate and volume of uterine myomas. Fertil Steril; 2006 May;85(5):1478-83
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  • [Title] Administration of goserelin acetate after uterine artery embolization does not change the reduction rate and volume of uterine myomas.
  • OBJECTIVE: To determine if goserelin immediately after uterine artery embolization (UAE) affected myoma reduction.
  • Uterine and myoma volumes were measured by ultrasound 2 weeks before UAE and at 3, 6, and 12 months.
  • CONCLUSION(S): The addition of goserelin therapy to UAE did not alter the reduction rate or volume of uterine myomas.

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  • (PMID = 16579996.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0F65R8P09N / Goserelin
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98. Mason TC, Adair J, Lee YC: Postpartum pyomyoma. J Natl Med Assoc; 2005 Jun;97(6):826-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Leiomyomata are common benign tumors of the uterus and female pelvis.
  • Myomas have been reported in 25% of Caucasian American women and 50% of African-American women.
  • Considering the high incidence of uterine myomata in women of reproductive age, they are reported as complications in only 2% of pregnancies.

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  • (PMID = 16035584.001).
  • [ISSN] 1943-4693
  • [Journal-full-title] Journal of the National Medical Association
  • [ISO-abbreviation] J Natl Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 9
  • [Other-IDs] NLM/ PMC2569512
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99. Yamada N, Uchida R, Fuchida S, Okano A, Okamoto M, Ochiai N, Iwasa H, Shimazaki C: CD5+ Epstein-Barr virus-positive intravascular large B-cell lymphoma in the uterus co-existing with huge myoma. Am J Hematol; 2005 Mar;78(3):221-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CD5+ Epstein-Barr virus-positive intravascular large B-cell lymphoma in the uterus co-existing with huge myoma.
  • Histologically, she was diagnosed as having intravascular lymphoma co-existing with myoma uteri.
  • She received the combination chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisolone) together with rituximab and has been well without definite disease progression.

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  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
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  • (PMID = 15726593.001).
  • [ISSN] 0361-8609
  • [Journal-full-title] American journal of hematology
  • [ISO-abbreviation] Am. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD5
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100. Bettocchi S, Di Spiezio Sardo A, Ceci O, Nappi L, Guida M, Greco E, Pinto L, Camporiale AL, Nappi C: A new hysteroscopic technique for the preparation of partially intramural myomas in office setting (OPPIuM technique): A pilot study. J Minim Invasive Gynecol; 2009 Nov-Dec;16(6):748-54
MedlinePlus Health Information. consumer health - Uterine Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A new hysteroscopic technique for the preparation of partially intramural myomas in office setting (OPPIuM technique): A pilot study.
  • OBJECTIVE: To assess the safety and the effectiveness of a novel hysteroscopic technique for the Office Preparation of Partially Intramural Myomas (OPPIuM), to facilitate the subsequent, already scheduled, resectoscopic myomectomy.
  • PATIENTS: Fifty-nine fertile women (age 27-48 years) diagnosed at office hysteroscopy as having symptomatic submucous myomas>1.5 cm with intramural development (G1 and G2), scheduled for resectoscopic surgery.
  • INTERVENTIONS: The OPPIuM technique consisted of an incision of the endometrial mucosa covering the myoma by means of Fr scissors or bipolar Versapoint Twizzle electrode, along its reflection line on the uterine wall, up to the precise identification of the cleavage surface between the myoma and its pseudo-capsule.
  • Such procedure was aimed at triggering the protrusion of the intramural portion of the myoma into the uterine cavity during the following menstrual cycles, thus facilitating the subsequent total removal of the lesion via resectoscopic surgery.
  • The mean diameter of successfully prepared myomas was 2.9+/-0.8 cm.
  • At follow-up hysteroscopy, the conversion of partially intramural myomas into totally or prevalently intracavitary ones was observed in 93.2% (55/59) of cases.
  • In 2 of 3 cases of failure, the myomas' size was>4 cm.
  • One patient was excluded from the study because of the occurrence of total spontaneous expulsion of the myoma at the subsequent menstrual cycle.
  • CONCLUSIONS: Our preliminary findings seem to support the safety and the effectiveness of the OPPIuM procedure by reporting the conversion of myomas with intramural development>1.5 cm into totally or prevalently intracavitary ones in nearly 93% of cases.
  • [MeSH-major] Ambulatory Surgical Procedures. Hysteroscopy / methods. Myoma / surgery. Uterine Neoplasms / surgery

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  • (PMID = 19896603.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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