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1. Tiufekchieva E: [Seven-year-experience in the hysteroresection of submucous myomas]. Akush Ginekol (Sofiia); 2007;46(4):23-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Seven-year-experience in the hysteroresection of submucous myomas].
  • AIM OF THE RESEARCH: to summarize the results of hysteroscopic resections of submucous myomas, performed in the last 7 years in our clinic and to compare the results with those cited in the literature.
  • RESULTS: 142 submucous myomas were resected.
  • The mean diameter was 32.15 mm (from 5 to 55 mm); 8 myomas were 50 mm and more in diameter.
  • After 3 years 7 women, out of 31 observed, had abnormal bleeding; 5 women underwent hysterectomies because of intramural myomas, atypical endometrial hyperplasia, endometrial cancer, uterine prolapse.
  • CONCLUSION: The results of the study confirmed the advantages and the excellent potentialities of the hysteroscopy in the treatment of the submucous myomas.
  • For this reason hysteroscopy should be the method of choice for treatment of the submucous myomas.

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  • (PMID = 17974191.001).
  • [ISSN] 0324-0959
  • [Journal-full-title] Akusherstvo i ginekologii︠a︡
  • [ISO-abbreviation] Akush Ginekol (Sofiia)
  • [Language] bul
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Bulgaria
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2. Salem F, Rosenblum MK, Jhanwar SC, Kancherla P, Ghossein RA, Carlson DL: Teratocarcinosarcoma of the nasal cavity and paranasal sinuses: report of 3 cases with assessment for chromosome 12p status. Hum Pathol; 2008 Apr;39(4):605-9
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  • Sinonasal teratocarcinosarcoma (SNTCS) is a rare malignant neoplasm with 63 reported cases to date.
  • Microscopic examination revealed admixed epithelial and mesenchymal elements in all 3 cases; benign squamous and glandular epithelium and neuroepithelial tissue were identified, the squamous epithelium demonstrating "fetal-like" cytoplasmic clearing.
  • Mesenchymal proliferations were recognized ranging from well-differentiated smooth muscle to high-grade sarcoma.
  • Our findings suggest that 12p amplification, if it occurs at all in this setting, is exceptional and that SNTCS is a somatic-type neoplasm exhibiting divergent differentiation rather than a germ cell tumor.

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  • (PMID = 18284932.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Østergaard JR, Smith T, Stausbøl-Grøn B: Intraneural perineurioma of the sciatic nerve in early childhood. Pediatr Neurol; 2009 Jul;41(1):68-70
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  • Intraneural perineurioma is an uncommon benign neoplasm characterized by focal perineural cell proliferation.
  • [MeSH-minor] Child, Preschool. Diagnosis, Differential. Electromyography. Humans. Magnetic Resonance Imaging. Male. Muscle, Skeletal / pathology. Muscle, Skeletal / physiopathology. Pelvis / pathology. Peroneal Neuropathies / diagnosis

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  • (PMID = 19520281.001).
  • [ISSN] 1873-5150
  • [Journal-full-title] Pediatric neurology
  • [ISO-abbreviation] Pediatr. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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4. Yavuz S, Eris C, Sezen M, Goncu T, Ata Y, Turk T: Recurrent multiple cardiac myxomas. Bratisl Lek Listy; 2010;111(10):549-51
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  • Multifocal growth of a benign myxoma or malignant transformation, inadequate resection, intraoperative implantation or embolization, familial disposition, and the abnormal DNA ploidy pattern play an important role in development of recurrent myxoma.
  • The patient underwent a redo-surgery and, in addition to a large myxoma in the right ventricle with involvement of the tricuspid valve and anterior papillary muscle, three myxomas including both myxomas originating at the top and the base of the posterior papillary muscle, respectively, the other myxoma between both papillary muscles in the posterior wall of the left ventricle, and 2 more small myxomas including 1 in the interatrial septum and the other on atrial surface of anterior mitral annulus were found in the left ventricle and atrium.
  • [MeSH-major] Heart Neoplasms / surgery. Myxoma / surgery. Neoplasm Recurrence, Local. Neoplasms, Multiple Primary / surgery

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  • (PMID = 21125800.001).
  • [ISSN] 0006-9248
  • [Journal-full-title] Bratislavské lekárske listy
  • [ISO-abbreviation] Bratisl Lek Listy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Slovakia
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5. Zhu L, Lang JH, Liu CY, Shi HH, Sun ZJ, Fan R: Clinical assessment for three routes of hysterectomy. Chin Med J (Engl); 2009 Feb 20;122(4):377-80
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  • METHODS: One hundred and one women undergoing hysterectomy for myoma had the procedure performed by laparoscopic assisted vaginal hysterectomy (LAVH), total vaginal hysterectomy (TVH) or total abdominal hysterectomy (TAH) in a randomized study.
  • Vaginal hysterectomy is the most cost-effective approach but the final choice for the route of hysterectomy can depend on many factors such as gynecological disease, patients' health status and experiences of the gynecologist.
  • [MeSH-major] Hysterectomy / methods. Hysterectomy / standards. Myoma / surgery

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  • (PMID = 19302739.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] China
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6. Jeremic K, Gojnic M, Milenkovic V, Boskovic V, Berisavac M, Zecević N: Placental site trophoblastic tumor: a case report. Eur J Gynaecol Oncol; 2006;27(1):98-100
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  • [Title] Placental site trophoblastic tumor: a case report.
  • Patient K.N., age 30, nulliparous deliveries and with one miscarriage, was admitted to the Institute of Gynecology and Obstetrics, Clinical Center of Serbia, in December 2000 with the following diagnosis: Uterine myoma and adnexal mass.
  • [MeSH-major] Chorionic Gonadotropin / blood. Trophoblastic Tumor, Placental Site / pathology. Trophoblastic Tumor, Placental Site / surgery. Uterine Neoplasms / pathology. Uterine Neoplasms / surgery
  • [MeSH-minor] Adult. Biopsy, Needle. Female. Follow-Up Studies. Humans. Hysterectomy / methods. Immunohistochemistry. Magnetic Resonance Imaging. Magnetic Resonance Spectroscopy. Neoplasm Staging. Pregnancy. Risk Assessment. Treatment Outcome

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  • (PMID = 16550983.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin
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7. Markowska A, Belloni AS, Rucinski M, Parenti AR, Nardelli GB, Drews K, Nussdorfer GG, Malendowicz LK: Leptin and leptin receptor expression in the myometrium and uterine myomas: Is leptin involved in tumor development? Int J Oncol; 2005 Dec;27(6):1505-9
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  • [Title] Leptin and leptin receptor expression in the myometrium and uterine myomas: Is leptin involved in tumor development?
  • Evidence has been provided that leptin, in addition to being involved in obesity development, plays a role in the regulation of the female reproductive system, angiogenesis and tumor growth.
  • Uterine myoma is a rather common disease that develops more frequently in obese than lean women, where plasma leptin concentrations are elevated.
  • RT-PCR and Western blotting showed that leptin was expressed, as mRNA and protein, in several uterine myomas but not in normal myometrium, while leptin receptors were expressed in both tissues.
  • Immunocytochemistry indicated that leptin-immunoreactivity was located in both myometrial cells and blood-vessel walls of uterine myomas.
  • Leptin(22-56), at concentrations of 10(-7) and 10(-6) M, enhanced the proliferative activity of both the normal myometrium and myoma cells in primary culture.
  • Taken together, our findings allow us to suggest that leptin, acting through autocrine-paracrine mechanism(s), may be involved in the development of uterine myomas.
  • [MeSH-major] Leptin / genetics. Myoma / genetics. Myometrium / metabolism. Receptors, Cell Surface / genetics. Uterine Neoplasms / genetics
  • [MeSH-minor] Blotting, Western. Cell Proliferation / drug effects. Dose-Response Relationship, Drug. Female. Gene Expression. Humans. Immunohistochemistry. RNA, Messenger / genetics. RNA, Messenger / metabolism. Receptors, Leptin. Reverse Transcriptase Polymerase Chain Reaction. Tumor Cells, Cultured

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  • (PMID = 16273205.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Leptin; 0 / RNA, Messenger; 0 / Receptors, Cell Surface; 0 / Receptors, Leptin; 0 / leptin receptor, human
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8. Jakobiec FA, Nguyen J, Bhat P, Fay A: MDM2-positive atypical lipomatous neoplasm/well-differentiated liposarcoma versus spindle cell lipoma of the orbit. Ophthal Plast Reconstr Surg; 2010 Nov-Dec;26(6):413-5
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  • [Title] MDM2-positive atypical lipomatous neoplasm/well-differentiated liposarcoma versus spindle cell lipoma of the orbit.
  • PURPOSE: To distinguish, in a 36-year-old man, an atypical lipomatous neoplasm/well-differentiated liposarcoma from a spindle cell lipoma in a recurrent orbital tumor.
  • METHODS: Clinical, radiographic, and histopathologic evaluations coupled with immunohistochemical studies for CD34, factor XIII, bcl-2, S-100, muscle-specific actin, Ki-67, and MDM2.
  • RESULTS: MDM2 gene amplification was discovered in the CD34 tumor cells.
  • CONCLUSION: Well-differentiated liposarcoma is a slow growing, infiltrative, and nonmetastasizing neoplasm that is microscopically and diagnostically challenging.
  • It can be reliably separated from a benign spindle cell or an atypical lipoma by using the markers MDM2 and Ki-67.
  • [MeSH-major] Biomarkers, Tumor / analysis. Lipoma / diagnosis. Liposarcoma / diagnosis. Orbital Neoplasms / diagnosis. Proto-Oncogene Proteins c-mdm2 / analysis

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  • (PMID = 20639786.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / S100 Proteins; 9013-56-3 / Factor XIII; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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9. Arrabal-Polo MA, Arrabal-Martin M: Resolution of right ureteral lesion after subtotal hysterectomy due to benign pathology. A clinical case study. Int Urogynecol J; 2010 Nov;21(11):1435-7
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  • [Title] Resolution of right ureteral lesion after subtotal hysterectomy due to benign pathology. A clinical case study.
  • INTRODUCTION: Ureteral lesion during gynecological surgery to correct benign uterine pathology is around 0.03-2.0%, and usually occurs at the ligature of blood vessels.
  • DISCUSSION: We describe here the case story of a 40-year-old female patient, who, after subtotal hysterectomy for myomas, presented with acute abdominal pain, and was diagnosed with a right ureteral lesion, via CAT imaging; the patient received direct ureterovesical implantation of double J catheter, which was kept in place for 8 weeks.

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  • [Cites] Obstet Gynecol. 2009 Jan;113(1):6-10 [19104353.001]
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  • (PMID = 20571768.001).
  • [ISSN] 1433-3023
  • [Journal-full-title] International urogynecology journal
  • [ISO-abbreviation] Int Urogynecol J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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10. Kang JL, Wang DY, Wang XX, Yu J: Up-regulation of apoptosis by gonadotrophin-releasing hormone agonist in cultures of endometrial cells from women with symptomatic myomas. Hum Reprod; 2010 Sep;25(9):2270-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Up-regulation of apoptosis by gonadotrophin-releasing hormone agonist in cultures of endometrial cells from women with symptomatic myomas.
  • BACKGROUND: The aim of the present study was to evaluate the effect of gonadotrophin-releasing hormone agonist (GnRH-a), which is widely used in the medical treatment of symptomatic myomas, on the rate of endometrial cell apoptosis in cultures from women with symptomatic myomas.
  • METHODS: The study included 36 women with symptomatic myomas without endometrial hyperplasia or endometrial carcinoma, and 22 controls.
  • RESULTS: Levels of spontaneous apoptosis were significantly lower in endometrial cultures from patients with symptomatic myomas than in those from control subjects (P < 0.01).
  • Concentrations as low as 10(-7) M GnRH-a enhanced apoptosis in endometrial cultures from patients with symptomatic myomas (3.48% +/- 0.27% apoptotic cells in untreated samples and 25.45 +/- 0.95% in cells treated with 10(-7) M GnRH-a; P <0.01).
  • CONCLUSIONS: GnRH-a stimulates apoptosis in endometrial cells from patients with symptomatic myomas and this could, at least in part, account for the therapeutic action of GnRH-a.
  • [MeSH-minor] Adult. Annexin A5 / metabolism. Biopsy. Female. Flow Cytometry. Humans. In Situ Nick-End Labeling. Middle Aged. Osmolar Concentration. Time Factors. Triptorelin Pamoate / pharmacology. Tumor Cells, Cultured. Uterine Hemorrhage / prevention & control

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  • (PMID = 20634188.001).
  • [ISSN] 1460-2350
  • [Journal-full-title] Human reproduction (Oxford, England)
  • [ISO-abbreviation] Hum. Reprod.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Annexin A5; 0 / Antineoplastic Agents, Hormonal; 33515-09-2 / Gonadotropin-Releasing Hormone; 57773-63-4 / Triptorelin Pamoate
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11. Hsu WC, Hwang JS, Chang WC, Huang SC, Sheu BC, Torng PL: Prediction of operation time for laparoscopic myomectomy by ultrasound measurements. Surg Endosc; 2007 Sep;21(9):1600-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The myoma weights were calculated and converted into mass units (g) by an assumed smooth muscle density of 1.04 g/cm3.
  • Myomas were weighed immediately after operation, and the correlation between these two weights was assessed by linear regression and limits of agreement.
  • RESULTS: Of 109 patients, 203 myomas were removed laparoscopically with a mean ultrasound-measured myoma weight of 137.9 (100.7) g, a diameter of the dominant myoma of 6.30 (1.92) cm, and an operation time of 125 (41) min.
  • Strong correlations were observed between the ultrasound-measured and operated myoma weights.
  • A predictive model, in which operation time = 0.14 x ultrasound-measured myoma weight + 1.68 x BMI + 5.21 x operated myoma number + 0.06 x (ultrasound-measured myoma weight x operated myoma number) + 43.97, was developed.
  • CONCLUSIONS: Operation time was significantly related to the myoma weight measured by ultrasound.

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  • (PMID = 17294306.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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12. Leite GK, Korkes HA, Viana Ade T, Pitorri A, Kenj G, Sass N: [Myomectomy in the second trimester of pregnancy: case report]. Rev Bras Ginecol Obstet; 2010 Apr;32(4):198-201
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Miomectomia em gestação de segundo trimestre: relato de caso.
  • Uterine leiomyomas are characterized as a benign disease and are observed in 2 to 3% of all normal pregnancies.
  • Ultrasonography revealed a myoma nodule measuring 9.1 x 7.7 cm; the patient was hospitalized and medicated, being also submitted to laparotomy and myomectomy due to worsening of her condition.

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  • (PMID = 20625689.001).
  • [ISSN] 1806-9339
  • [Journal-full-title] Revista brasileira de ginecologia e obstetrícia : revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
  • [ISO-abbreviation] Rev Bras Ginecol Obstet
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Brazil
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13. Suzuki T, Ueda Y, Shincho M, Mitsui Y, Higuchi Y, Maruyama T, Kondoh N, Nojima M, Yamamoto S, Hirota S, Shima H: [Myolipoma arising from the renal capsule: a case report]. Hinyokika Kiyo; 2008 May;54(5):349-52
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  • Computed tomorraphy and magnetic resonance imaging showed that the tumor was mixed with muscle and fat tissue, faintly enhanced, and located at the lower portion of the left kidney.
  • Although renal angiomyolipoma (AML) was suspected from these findings, we could not rule out a malignant tumor.
  • Histopathological examination revealed the tumor composed of smooth muscle and mature adipose tissue without cytological atypia arising from the renal capsule.
  • The tumor contained no AML-like blood vessels, and was negative for HMB-45 staining.
  • Myolipoma is a rare benign neoplasm in the soft tissue of retroperitoneum and abdominal cavity.
  • Since it is difficult to distinguish myolipoma from other benign and malignant tumors with fat tissue only by imaging studies, a surgical approach should be considered.

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  • (PMID = 18546859.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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14. Erian J, El-Toukhy T, Chandakas S, Theodoridis T, Hill N: One hundred cases of laparoscopic subtotal hysterectomy using the PK and Lap Loop systems. J Minim Invasive Gynecol; 2005 Jul-Aug;12(4):365-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • DESIGN: Prospective observational study (Canadian Task Force classification II-2).
  • Clinically, the uterus was enlarged in 70 patients, and preoperative ultrasound scanning suggested the presence of uterine myomas in 42 patients.

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  • (PMID = 16036200.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Hsieh CH, Wei MC, Hsu YP, Chong NS, Chen YJ, Hsiao SM, Hsieh YP, Wang LY, Shueng PW: Should helical tomotherapy replace brachytherapy for cervical cancer? Case report. BMC Cancer; 2010;10:637
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  • Magnetic resonance imaging (MRI) showed a cervical tumor with direct invasion of the right parametrium, bilateral hydronephrosis, and multiple uterine myomas.
  • International Federation of Gynecology and Obstetrics (FIGO) stage IIIB cervical cancer was diagnosed.
  • Concurrent chemoradiation therapy (CCRT) followed by SBRT delivered via HT was administered instead of brachytherapy because of the presence of multiple uterine myomas with bleeding tendency.
  • Total abdominal hysterectomy was performed after 6 weeks of treatment because of the presence of multiple uterine myomas.
  • Neither pelvic MRI nor results of histopathologic examination at X-month follow-up showed evidence of tumor recurrence.
  • [MeSH-minor] Biopsy. Chemotherapy, Adjuvant. Dose Fractionation. Female. Humans. Hysterectomy. Magnetic Resonance Imaging. Middle Aged. Neoplasm Invasiveness. Treatment Outcome. Uterine Hemorrhage / etiology. Uterine Hemorrhage / therapy. Vaginal Smears

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  • (PMID = 21092235.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3001446
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16. Lasmar RB, Barrozo PR, Dias R, Oliveira MA: Submucous myomas: a new presurgical classification to evaluate the viability of hysteroscopic surgical treatment--preliminary report. J Minim Invasive Gynecol; 2005 Jul-Aug;12(4):308-11
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  • [Title] Submucous myomas: a new presurgical classification to evaluate the viability of hysteroscopic surgical treatment--preliminary report.
  • STUDY OBJECTIVE: To develop a new preoperative classification of submucous myomas for evaluating the viability and the degree of difficulty of hysteroscopic myomectomy.
  • DESIGN: Retrospective study (Canadian Task Force classification II-3) SETTING: University teaching hospitals.
  • PATIENTS: Fifty-five patients who underwent hysteroscopic resection of submucous myomas.
  • INTERVENTION: The possibility of total resection of the myoma, the operating time, the fluid deficit, and the frequency of any complications were considered.
  • The myomas were classified according to the Classification of the European Society for Gynaecological Endoscopy (ESGE) and by our group's new classification (NC), which considers not only the degree of penetration of the myoma into the myometrium, but also adds in such parameters as the distance of the base of the myoma from the uterine wall, the size of the nodule (cm), and the topography of the uterine cavity.
  • MEASUREMENTS AND MAIN RESULTS: In 57 myomas, hysteroscopic surgery was considered complete.
  • CONCLUSIONS: We believe that the NC gives more clues as to the difficulties of a hysteroscopic myomectomy than the standard ESGE classification.
  • It should be stressed that the number of hysteroscopic myomectomies used in this analysis was low, and it would be interesting to evaluate the performance of the classification in a larger number of patients.
  • [MeSH-major] Hysteroscopy. Leiomyoma / classification. Leiomyoma / surgery. Uterine Neoplasms / classification. Uterine Neoplasms / surgery

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  • (PMID = 16036188.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. McCluggage WG, Boyde A: Uterine angioleiomyomas: a report of 3 cases of a distinctive benign leiomyoma variant. Int J Surg Pathol; 2007 Jul;15(3):262-5
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  • [Title] Uterine angioleiomyomas: a report of 3 cases of a distinctive benign leiomyoma variant.
  • They were composed of bland, spindle-shaped cells with numerous evenly distributed, arteriole-like vessels with thick muscular walls throughout.
  • The spindle cells were positive with smooth-muscle markers and negative with HMB45.
  • We believe angioleiomyoma should be recognized as a distinct entity and included in the World Health Organization classification of tumors of the female genital tract as a benign leiomyoma variant, similar to cellular and atypical leiomyoma.
  • Uterine angioleiomyoma has a close morphological resemblance to the similarly named skin tumor.
  • We review uterine smooth-muscle and other mesenchymal neoplasms in which prominent vascular channels are a feature.
  • [MeSH-minor] Actins / genetics. Actins / metabolism. Adult. Antigens, Neoplasm. Calmodulin-Binding Proteins / genetics. Calmodulin-Binding Proteins / metabolism. Desmin / genetics. Desmin / metabolism. Female. Gene Expression Regulation, Neoplastic. Humans. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism

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  • (PMID = 17652533.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / Calmodulin-Binding Proteins; 0 / Desmin; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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18. Nasiadek M, Krawczyk T, Sapota A: Tissue levels of cadmium and trace elements in patients with myoma and uterine cancer. Hum Exp Toxicol; 2005 Dec;24(12):623-30
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  • [Title] Tissue levels of cadmium and trace elements in patients with myoma and uterine cancer.
  • The aim of this study was to investigate the cadmium (Cd), copper (Cu), zinc (Zn), iron (Fe), magnesium (Mg) and calcium (Ca) concentrations in uterine cancer and uterine myoma.
  • Tissue levels of six elements in 15 uterine cancers and 28 uterine myomas were measured by atomic absorption spectrometry.
  • The samples were collected from women aged 32-79 (uterine myomas, uterine cancer and non-lesion uterine tissues from the same women).
  • The results showed that the tissue Cd concentration was significantly lower in myoma than in non-lesion tissue.
  • In uterine myoma, a significant increase of Mg and Mg/Ca ratio, as well as a decrease in Fe concentration were found.
  • Statistical analysis showed no correlation between smoking habits, age, menopausal status and concentration of Cu, Zn, Fe, Mg and Ca trace metals in myoma or cancer tissue.

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  • (PMID = 16408615.001).
  • [ISSN] 0960-3271
  • [Journal-full-title] Human & experimental toxicology
  • [ISO-abbreviation] Hum Exp Toxicol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Trace Elements; 00BH33GNGH / Cadmium
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19. Koseoglu RD, Ozkan N, Filiz NO, Kayaoglu HA, Aydin M, Culha EN, Ersoy OF: Intranodal palisaded myofibroblastoma; a case report and review of the literature. Pathol Oncol Res; 2009 Jun;15(2):297-300
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  • Intranodal palisaded myofibroblastoma (IPM) also called as intranodal hemorrhagic spindle cell tumor with amianthoid fibers is a distinctive and rare mesenchymal neoplasm of lymph nodes.
  • In contrast to Kaposi's sarcoma, it behaves in a benign fashion and does not need any further therapy except total surgical resection of the mass.
  • This neoplasm has a great predilection for the inguinal region.
  • We present a 43-year-old-male patient with IPM and discuss histological, immunohistochemical features and pathogenesis of this rare benign neoplasm.
  • [MeSH-major] Carcinoma / pathology. Lymph Nodes / pathology. Neoplasms, Muscle Tissue / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Humans. Immunoenzyme Techniques. Male

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  • (PMID = 18991023.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 20
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20. Touboul C, Fernandez H, Deffieux X, Berry R, Frydman R, Gervaise A: Uterine synechiae after bipolar hysteroscopic resection of submucosal myomas in patients with infertility. Fertil Steril; 2009 Nov;92(5):1690-3
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  • [Title] Uterine synechiae after bipolar hysteroscopic resection of submucosal myomas in patients with infertility.
  • INTERVENTION(S): Patients underwent bipolar hysteroscopic resection of myomas between 2001 and 2006, and an outpatient hysteroscopy was performed 2 months after the fibroid resection.
  • RESULT(S): The submucosal myomas were intracavitary class 0 (n = 12), intramural class 1 (n = 19), and intramural class 2 (n = 22).
  • The mean myoma size was 25 +/- 11 mm.
  • Myoma size >or=3.5 cm and age <35 years were associated with a significantly higher pregnancy rate in univariate and multivariate analysis.
  • [MeSH-major] Hysteroscopy / adverse effects. Infertility, Female / epidemiology. Myoma / surgery. Uterine Diseases / epidemiology. Uterine Neoplasms / surgery


21. Fleshman RL, Wasman JK, Bodner DG, Young RH, MacLennan GT: Mesodermal adenosarcoma of the testis. Am J Surg Pathol; 2005 Mar;29(3):420-3
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  • Biphasic neoplasms with a benign to atypical epithelial component and a usually low-grade malignant stromal component have been reported in various sites, probably being best known for their occurrence in the uterine corpus (mullerian adenosarcoma).
  • We report a tumor of this type that occurred in the testis of a 76-year-old man and, to our knowledge, is the first mesodermal adenosarcoma reported at this site.
  • A large complex solid-cystic testicular tumor was evident on ultrasound, and examination of a radical orchiectomy specimen showed a 6.5-cm mass.
  • On microscopic examination, the neoplasm had a phyllodes-like appearance with bland cuboidal to flattened epithelium covering polypoid fronds, and lining glands and cysts.
  • It was immunoreactive for muscle specific actin, CD10, and to a lesser degree, desmin.
  • [MeSH-major] Adenosarcoma / pathology. Mixed Tumor, Mesodermal / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Actins / metabolism. Aged. Biomarkers, Tumor / metabolism. Desmin / metabolism. Humans. Male. Neprilysin / metabolism. Orchiectomy. Treatment Outcome

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  • (PMID = 15725814.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Desmin; EC 3.4.24.11 / Neprilysin
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22. Dilek S, Ertunc D, Tok EC, Cimen R, Doruk A: The effect of myomectomy on health-related quality of life of women with myoma uteri. J Obstet Gynaecol Res; 2010 Apr;36(2):364-9
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  • [Title] The effect of myomectomy on health-related quality of life of women with myoma uteri.
  • Many studies have evaluated the effect of other methods rather than myomectomy on HRQoL, and have focused solely on the presence of myoma without regarding any concurrent pelvic pathology.
  • METHODS: This study involved 80 patients with myomas and 75 controls.
  • Domains of the Short Form - 36 (SF-36) questionnaire were evaluated pre- and postoperatively in 72 women with myomas.
  • Furthermore, any correlations between myoma characteristics and SF-36 physical components (PC) and mental components (MC) were investigated.
  • RESULTS: All SF-36 domains were lower in women with myoma uteri than in the control group, except for physical and social function.
  • There was no correlation between PC and MC scores and the number, location and total volume of the myomas.
  • However, fundal and posteriorly positioned myomas were related with the PC score, and posterior myomas with the MC score.
  • CONCLUSION: The findings from this study suggest that myomectomy improves HRQoL, and that myoma characteristics may modulate quality of life domains.

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  • (PMID = 20492389.001).
  • [ISSN] 1447-0756
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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23. Ozturk E, Ugur MG, Balat O, Kutlar I, Dikensoy E, Cebesoy B: An analysis of hysteroscopy experience over a seven-year period. Clin Exp Obstet Gynecol; 2010;37(2):150-1
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  • The most common pathologies for referal to operative hysteroscopy were uterine septum, endometrial polyps, Asherman's syndrome, submucous myomas, and other uterine anomalies.
  • [MeSH-major] Hysteroscopy. Uterine Diseases / diagnosis

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  • (PMID = 21077511.001).
  • [ISSN] 0390-6663
  • [Journal-full-title] Clinical and experimental obstetrics & gynecology
  • [ISO-abbreviation] Clin Exp Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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24. Kook PH, Wiederkehr D, Makara M, Reusch CE: [Megaesophagus secondary to an esophageal leiomyoma and concurrent esophagitis]. Schweiz Arch Tierheilkd; 2009 Oct;151(10):497-501
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  • The only clinical abnormality was halitosis, a neurological examination was normal.
  • No other disorder causing abnormal esophageal motor function could be identified.
  • Microscopically a leio-myoma with mild multifocal mixed-cell esophagitis was diagnosed.
  • This report illustrates how a potentially curable disease such as leiomyoma can clinically mimic acquired idiopathic megaesophagus and emphasizes that additional diagnostic procedures (contrast study, esophagoscopy) can be indicated in individual cases.
  • [MeSH-major] Dog Diseases / diagnosis. Esophageal Achalasia / veterinary. Esophageal Neoplasms / veterinary. Esophagitis / veterinary. Leiomyoma / veterinary

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  • (PMID = 19780011.001).
  • [ISSN] 0036-7281
  • [Journal-full-title] Schweizer Archiv für Tierheilkunde
  • [ISO-abbreviation] Schweiz. Arch. Tierheilkd.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Switzerland
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25. Chen HW, Tzeng CR: Applications of microarray in reproductive medicine. Chang Gung Med J; 2006 Jan-Feb;29(1):15-24
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  • Recent studies of microarray-related techniques used to study oocyte fertilization, early embryo development, implantation and some infertility-related diseases (endometriosis and myoma) are discussed and summarized in this review.

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  • (PMID = 16642725.001).
  • [ISSN] 2072-0939
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China (Republic : 1949- )
  • [Number-of-references] 64
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26. Krysiak R, Okopień B, Herman ZS: [Gonadotropin-releasing hormone analogs]. Pol Merkur Lekarski; 2005 May;18(107):585-9
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  • Moreover, we review the potential role of these agents in pharmacotherapy of endometriosis, uterine myomas and central precocious puberty.

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  • (PMID = 16161962.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Chemical-registry-number] 33515-09-2 / Gonadotropin-Releasing Hormone
  • [Number-of-references] 38
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27. Makris N, Vomvolaki E, Mantzaris G, Kalmantis K, Hatzipappas J, Antsaklis A: Role of a bipolar resectoscope in subfertile women with submucous myomas and menstrual disorders. J Obstet Gynaecol Res; 2007 Dec;33(6):849-54
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  • [Title] Role of a bipolar resectoscope in subfertile women with submucous myomas and menstrual disorders.
  • METHODS: From January 2000 to December 2005, we studied 59 women of reproductive age with menorrhagia, submucous myomas and one or more infertility factors.
  • Fifteen of the 59 women displayed submucous myoma type O (intracavitary), 34 displayed submucous myoma type I (less than 50% within the myometrium) and the remaining 10 women displayed myoma type II (over 50% being within the myometrium).
  • The mean age and standard deviation of these patients was 34.6 +/- 4.4 years and the average size of myomas was 15 +/- 10 mm.
  • Treatment of these myomas was by hysteroscopic resection using a bipolar resectoscope.
  • The pregnancy rate was notably higher when the sole reason of subfertility was the presence of myoma (54.16%), and when the size of the myoma was equal to 2.5 cm (75%) or more.
  • CONCLUSION: The use of the bipolar resectoscope in hysteroscopic removal of small submucous myomas is shown to be both feasible and effective in controlling menorrhagia and increasing the pregnancy rate in subfertile women, when submucous myomas are the only reason of infertility.

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  • (PMID = 18001453.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Japan
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28. Takeuchi H, Kitade M, Kikuchi I, Shimanuki H, Kumakiri J, Kinoshita K: Adhesion-prevention effects of fibrin sealants after laparoscopic myomectomy as determined by second-look laparoscopy: a prospective, randomized, controlled study. J Reprod Med; 2005 Aug;50(8):571-7
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  • A total of 91 patients showing a minimal myoma > 5 cm, excluding pedunculated myomas, underwent LM alone: 32 patients in the control group, 29 in the fibrin gel group and 30 patients in the fibrin sheet group.
  • Although no significant differences were found in the incidence of de novo adnexal adhesions, the lowest rate was found in the fibrin gel group, with 4/32 patients (12.5%) in the control group, 2/29 patients (6.8%) in the fibrin gel group and 5/30 patients (16.7%) in the fibrin sheet group.
  • CONCLUSION: After LM for myomas as large as > or = 5 cm, postoperative adhesions were observed in > or = 50% of patients.
  • [MeSH-major] Fibrin Tissue Adhesive / therapeutic use. Leiomyoma / surgery. Postoperative Complications / prevention & control. Tissue Adhesives / therapeutic use. Uterine Diseases / prevention & control. Uterine Neoplasms / surgery

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  • (PMID = 16220761.001).
  • [ISSN] 0024-7758
  • [Journal-full-title] The Journal of reproductive medicine
  • [ISO-abbreviation] J Reprod Med
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fibrin Tissue Adhesive; 0 / Gels; 0 / Tissue Adhesives
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29. Sicaja M, Namiq A, Forster J, Damjanov I: Myxoid leiomyosarcoma of the liver. Pathol Res Pract; 2006;202(1):43-6
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  • The tumor was resected from a 64-year-old man.
  • The tumor was composed of deceptively benign-looking smooth muscle cells with clear cytoplasm suspended in a myxoid stroma with foci of hemorrhage.
  • Immunohistochemistry and electron microscopy confirmed that this was a smooth muscle cell neoplasm.
  • The abundance of glycogen and ultrastructural signs of smooth muscle differentiation were considered consistent with an immature smooth muscle cell phenotype consistent with the diagnosis of myxoid leiomyosarcoma.
  • [MeSH-minor] Biomarkers, Tumor. Humans. Male. Middle Aged

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  • (PMID = 16316722.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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30. Kongnyuy EJ, van den Broek N, Wiysonge CS: A systematic review of randomized controlled trials to reduce hemorrhage during myomectomy for uterine fibroids. Int J Gynaecol Obstet; 2008 Jan;100(1):4-9
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  • There was no evidence of effect in blood loss with myoma enucleation by morcellation and oxytocin.

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  • (PMID = 17894936.001).
  • [ISSN] 0020-7292
  • [Journal-full-title] International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • [ISO-abbreviation] Int J Gynaecol Obstet
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0E43V0BB57 / Misoprostol; 11000-17-2 / Vasopressins; 50-56-6 / Oxytocin; Y8335394RO / Bupivacaine
  • [Number-of-references] 25
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31. Horo GA, Touré-Ecra FA, Fanny M, N'Gbesso D, Koné M: [Diagnosis of endometrial pathologies in West Africa: contribution of saline infusion sonography. Experience of Yopougon's teaching hospital (Abidjan, Ivory Coast)]. Gynecol Obstet Fertil; 2006 Dec;34(12):1142-6
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  • [Transliterated title] Diagnostic des pathologies endométriales en Afrique subsaharienne: contribution de l'hystérosonographie. Expérience du CHU de Yopougon (Abidjan, Côte d'Ivoire).
  • The polyps (23,8%), and the mucous myomas (14%) dominate the endometrial pathologies.
  • [MeSH-major] Uterine Diseases / diagnosis. Uterine Diseases / ultrasonography. Uterus / ultrasonography

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  • (PMID = 17113809.001).
  • [ISSN] 1297-9589
  • [Journal-full-title] Gynécologie, obstétrique & fertilité
  • [ISO-abbreviation] Gynecol Obstet Fertil
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 451W47IQ8X / Sodium Chloride
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32. Kaymak O, Ustunyurt E, Okyay RE, Kalyoncu S, Mollamahmutoglu L: Myomectomy during cesarean section. Int J Gynaecol Obstet; 2005 May;89(2):90-3
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  • MATERIALS AND METHODS: Using a retrospective case-control design; 40 patients who underwent myomectomy at time of cesarean delivery were compared with the control group consisted of 80 patients with myomas who underwent cesarean delivery alone.


33. Blockeel C, De Beeck BO, Bourgain C, Amy JJ: Myomatous erythrocytosis syndrome. Natl Med J India; 2005 Sep-Oct;18(5):247-9
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  • Uterine myomas are common but erythrocytosis caused by these is rarely seen.
  • A voluminous, retroperitoneally located and focally degenerated myoma was associated with severe secondary erythrocytosis (haematocrit: 65.5%) which resolved after hysterectomy.
  • Local tissue hypoxia, which is more prone to develop in a pedunculated myoma, stimulates the process.
  • Other prerequisites are a very large size of the myoma and the absence of menometrorrhagia of a severity such as to cause a depletion in iron reserves.

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  • (PMID = 16433138.001).
  • [ISSN] 0970-258X
  • [Journal-full-title] The National medical journal of India
  • [ISO-abbreviation] Natl Med J India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Receptors, Erythropoietin; 11096-26-7 / Erythropoietin
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34. Basu D, Sengupta A, Adhikari D, Dam A, Anwar T: Granular cell myoblastoma of the tongue in a 2-year-old girl: a case report. J Indian Med Assoc; 2010 Mar;108(3):170, 175
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  • It is not clear whether or not granular cell tumour is a true neoplasm, a developmental anomaly, or a trauma-induced proliferation.
  • The basic cell of origin is now thought to be neural, although past reports frequently indicated an origin from striated muscle, or less frequently an origin from histiocytes, fibroblasts or pericytes.
  • The tumour generally occurs in middle or older aged adults.
  • Histochemical and ultrastructural studies propose the origin of the lesion from Schwann cells, striated muscle, mesenchymal cells, histiocytes and epithelial cells.
  • As most of the granular cell tumours are benign, surgical excision of the lesion is the treatment of choice.
  • [MeSH-major] Granular Cell Tumor / pathology. Tongue Neoplasms / pathology

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  • (PMID = 21043356.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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35. Cuadra Zelaya F, Quezada Rivera D, Tapia Vazquez JL, Paez Valencia C, Gaitán Cepeda LA: Plasmacytoid myoepithelioma of the palate. Report of one case and review of the literature. Med Oral Patol Oral Cir Bucal; 2007 Dec;12(8):E552-5
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  • INTRODUCTION: Myoepithelioma is a benign neoplasm of salivary glands, represents 1.5 % of all salivary glands neoplasm.
  • The lesion was analysed with immunohistochemical technique using the follow antibodies: vimentin, citokeratin AE1/AE3, S100 protein and actin muscle specific.
  • We observe positive immunoreactivity against vimentin, citokeratin, S100 protein and actin muscle specific.

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  • (PMID = 18059237.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 16
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36. Holub Z, Mára M: [Myomas, fertility and pregnancy]. Ceska Gynekol; 2008 Oct;73(5):307-13
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  • [Title] [Myomas, fertility and pregnancy].
  • OBJECTIVE: The objective of this paper is give to guideline to the management of myoma, fertility and pregnancy.


37. Kusumi T, Minakawa M, Fukui K, Saito S, Ohashi M, Sato F, Fukuda I, Kijima H: Cardiac tumor comprising two components including typical myxoma and atypical hypercellularity suggesting a malignant change. Cardiovasc Pathol; 2009 Nov-Dec;18(6):369-74
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  • [Title] Cardiac tumor comprising two components including typical myxoma and atypical hypercellularity suggesting a malignant change.
  • BACKGROUND: Cardiac myxoma is a benign neoplasm and is not considered to carry a risk of malignant transformation.
  • We describe a case of a cardiac tumor comprising typical myxoma and atypical cellular parts.
  • METHODS AND RESULTS: A 72-year-old woman was found to have a tumor in the left atrial chamber after undergoing echocardiographic investigation and so she underwent tumor excision surgery.
  • The excised tumor was composed of two components with different features with a smooth transition from one type to the other.
  • The apex of the tumor showed a gelatinous and villous appearance on gross examination, and histological examination revealed that the tumor cells had small oval nuclei and eosinophilic cytoplasm and were arranged in cords and vasoformative structures in the myxoid matrix.
  • The base of the tumor appeared as a solid mass on gross examination with hypercellular proliferation of spindle-shaped tumor cells and intersecting fascicles observed histologically.
  • On immunohistochemistry, the tumor cells were found to be positive for alpha-smooth muscle actin, calretinin, and CD34, and this immunoreactivity was decreased at the tip.
  • CONCLUSIONS: We diagnosed this tumor as cardiac myxoma with an atypical hypercellular component suggesting a malignant change.

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  • (PMID = 18619858.001).
  • [ISSN] 1879-1336
  • [Journal-full-title] Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
  • [ISO-abbreviation] Cardiovasc. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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38. Zhang YX, Chen HL, Ye B, Yang F, Yu LY: [Study on expression and methylation of caveolin 1 gene in non-small cell lung cancers]. Zhonghua Bing Li Xue Za Zhi; 2008 May;37(5):300-4
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  • METHODS: Immunohistochemistry and quanta Qd600 staining were used to detect the expression of Cav-1 in tissues from benign lung lesions (n = 17) and NSCLC (n = 123).
  • RESULTS: Cav-1 protein was highly expressed in cytoplasm and cell membrane of normal bronchial epithelium, alveolar epithelium, endothelial cells, fibroblasts and smooth muscle cells.
  • Amongst the NSCLC group, there was no statistically significant difference in Cav-1 protein expression in different histologic types (P = 0.552) and tumor grades (P = 0.160).
  • On the other hand, Cav-1 protein immunoreactivity was remarkably higher in advanced tumor stage: 72.7% in stage III A + III B, compared with 9.4% in stage I A + I B and 38.3% in stage II A + II B (P = 0.001).
  • CONCLUSIONS: High expression of Cav-1 protein is respected of the aggressive clinical behavior and advanced tumor stage.
  • [MeSH-minor] Aged. DNA Methylation. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging / methods. Somatoform Disorders

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  • (PMID = 18956646.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Caveolin 1
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39. Nikolov A, Nashar S, Jankova J, Jarukova N, Dimitrov A: [Caesarean section by vertical incision of lower uterine segment]. Akush Ginekol (Sofiia); 2009;48(3):3-9
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  • RESULTS. Vertical incision of the uterus is performed in 57.5% due to prematurity and lack of enough space for transversal incision (lower uterine segment not yet formed), in 25 % the cause is situs transverses of the foetus and the rest of the cases are related with technical difficulties in isthmicotransversal approach (myoma praevia, anomalies of the uterus, adhesions of the omentum). C.S. is performed for mean 66 min. in the main group vs. 74 min. with controls (p < 0.05).

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  • (PMID = 20198756.001).
  • [ISSN] 0324-0959
  • [Journal-full-title] Akusherstvo i ginekologii︠a︡
  • [ISO-abbreviation] Akush Ginekol (Sofiia)
  • [Language] bul
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Bulgaria
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40. Wang PH, Liu WM, Fuh JL, Chao HT, Chao KC, Yuan CC: Laparoscopic uterine vessel occlusion in the treatment of women with symptomatic uterine myomas with and without adding laparoscopic myomectomy: 4-year results. J Minim Invasive Gynecol; 2008 Nov-Dec;15(6):712-8
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  • [Title] Laparoscopic uterine vessel occlusion in the treatment of women with symptomatic uterine myomas with and without adding laparoscopic myomectomy: 4-year results.
  • STUDY OBJECTIVE: To estimate the necessity of laparoscopic myomectomy (LM) in the treatment of women with symptomatic uterine myomas who are undergoing laparoscopic uterine vessel occlusion (LUVO).
  • DESIGN: A comparative observational study (Canadian Task Force classification II-3).
  • PATIENTS: In all, 163 patients with symptomatic, uncomplicated myomas warranting myomectomy.
  • INTERVENTIONS: Symptomatic myomas treated by LUVO with or without LM.
  • CONCLUSION: Although LUVO is a less invasive procedure in the treatment of most women with symptomatic myomas, it is also less effective for symptom control and has shorter durable symptom relief compared with LUVO+LM.
  • [MeSH-minor] Adult. Female. Humans. Hysterectomy / methods. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Parity. Pregnancy. Retrospective Studies

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  • (PMID = 18971134.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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41. Cheng MH, Wang PH: Uterine myoma: a condition amenable to medical therapy? Expert Opin Emerg Drugs; 2008 Mar;13(1):119-33
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  • [Title] Uterine myoma: a condition amenable to medical therapy?
  • BACKGROUND: Uterine myomas are the most common benign tumors of the female reproductive tract.
  • OBJECTIVE: To review the literature on medical treatments that are available or being developed for women with uterine myomas.
  • METHODS: Literature review of articles pertaining to medical therapeutic strategies of uterine myomas. (Articles were searched by means of a computerized PubMed and Cochrane Library search with the following keywords: uterine myomas, leiomyomata, fibroids, and medical treatment.
  • This review will explore the recent advances in medical treatment for the management of uterine myomas.
  • [MeSH-major] Leiomyoma / therapy. Myoma / therapy. Uterine Neoplasms / therapy

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  • (PMID = 18321152.001).
  • [ISSN] 1744-7623
  • [Journal-full-title] Expert opinion on emerging drugs
  • [ISO-abbreviation] Expert Opin Emerg Drugs
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 191
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42. Yan L, Tian Y, Fu Y, Zhao X: Successful pregnancy after fertility-preserving surgery for endometrial stromal sarcoma. Fertil Steril; 2010 Jan;93(1):269.e1-3
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  • PATIENT(S): A 25-year-old woman (gravida 0, para 0) with a misdiagnosis of myoma who received a pathologic diagnosis of endometrial stromal sarcoma after the first surgery.
  • CONCLUSION(S): Endometrial stromal sarcoma is a rare uterine tumor with a poor prognosis.

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  • [Copyright] Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
  • (PMID = 19880109.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Richter C, Baetje M, Bischof A, Makovitzky J, Richter DU, Gerber B, Briese V: Expression of the glycodelin A gene and the detection of its protein in tissues and serum of ovarian carcinoma patients. Anticancer Res; 2007 Jul-Aug;27(4A):2023-5
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  • MATERIALS AND METHODS: We investigated serum, tissue and cyst fluid samples of patients with an ovarian carcinoma in contrast to patients with benign and malignant diseases such as uterine myoma, endometriosis, cervical, uterine and breast cancer, and metastases of bladder and colon carcinoma.
  • CONCLUSION: These results indicate that determination of GdA is not sensitive or specific enough for use as a tumour marker.
  • [MeSH-major] Biomarkers, Tumor / analysis. Gene Expression. Glycoproteins / biosynthesis. Ovarian Neoplasms / diagnosis. Pregnancy Proteins / biosynthesis

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  • (PMID = 17649816.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glycoproteins; 0 / PAEP protein, human; 0 / Pregnancy Proteins; 0 / RNA, Messenger
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44. Kim MD, Lee HS, Lee MH, Kim HJ, Cho JH, Cha SH: Long-term results of symptomatic fibroids treated with uterine artery embolization: in conjunction with MR evaluation. Eur J Radiol; 2010 Feb;73(2):339-44
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  • Tumor regrowth from incomplete infarction was a cause of recurrence in one patient and newly developed leiomyomas in the other one.
  • Of the 14 necrotic myomas on short-term follow up MR after UFE, eight (57.1%) demonstrated maintaining necrosis with further shrinkage and six (42.9%) were no longer visualized on long-term follow up MR images.
  • Long-term MR imaging after UFE revealed persistent necrotic fibroid, non-visualization of fibroids and tumor regrowth when incompletely infarcted.

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  • [Copyright] Copyright (c) 2008 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19084365.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Ireland
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45. Chen SY, Chang DY, Sheu BC, Torng PL, Huang SC, Hsu WC, Chang WC: Laparoscopic-assisted vaginal hysterectomy with in situ morcellation for large uteri. J Minim Invasive Gynecol; 2008 Sep-Oct;15(5):559-65
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  • DESIGN: Prospective study (Canadian Task Force classification II-1).
  • PATIENTS: In all, 147 women with myoma or adenomyosis weighing more than 500 g from January 2004 through December 2007 were enrolled.

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  • (PMID = 18657481.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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46. Palomba S, Zupi E, Zullo F: Fanfani F, et al. A prospective study of laparoscopy versus minilaparotomy in the treatment of uterine myomas. J Minim Invasive Gynecol; 2006 May-Jun;13(3):253; author reply 253-4
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  • [Title] Fanfani F, et al. A prospective study of laparoscopy versus minilaparotomy in the treatment of uterine myomas.

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  • [CommentOn] J Minim Invasive Gynecol. 2005 Nov-Dec;12(6):470-4 [16337572.001]
  • (PMID = 16698538.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fertility Agents, Female; 33515-09-2 / Gonadotropin-Releasing Hormone
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47. Lee WL, Liu WM, Fuh JL, Tsai YC, Shih CC, Wang PH: Use of uterine vessel occlusion in the management of uterine myomas: two different approaches. Fertil Steril; 2010 Oct;94(5):1875-81
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  • [Title] Use of uterine vessel occlusion in the management of uterine myomas: two different approaches.
  • OBJECTIVE: To evaluate the difference between uterine artery occlusion alone (UAO) and combined (UVO) with simultaneous blockage of anastomosis between the uterine and ovarian vessels in the management of women with myomas in a 3-year follow-up.
  • This finding is worthy of further investigation.
  • [MeSH-major] Gynecologic Surgical Procedures / methods. Myoma / surgery. Uterine Artery / surgery. Uterine Neoplasms / surgery. Vascular Surgical Procedures / methods

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  • [Copyright] Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20045514.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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48. Lupattelli T, Clerissi J, Basile A, Minnella DP, Donati Sarti R, Gerli S, Di Renzo G: [Treatment of uterine fibromyoma with bilateral uterine artery embolization: state of the art]. Minerva Ginecol; 2007 Aug;59(4):427-39
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  • The gynecologist is likely to be the primary initial consultant to patients who present with myomas symptoms.

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  • (PMID = 17923833.001).
  • [ISSN] 0026-4784
  • [Journal-full-title] Minerva ginecologica
  • [ISO-abbreviation] Minerva Ginecol
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 72
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49. Ferrero S, Bentivoglio G: Adenomyosis in a patient with mosaic Turner's syndrome. Arch Gynecol Obstet; 2005 Mar;271(3):249-50
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  • At transabdominal ultrasound a myoma (15 x 8.5 x 8 cm) arising from the posterior uterine wall was suspected.
  • Histologic examination confirmed the presence of the myoma and revealed the presence of focal adenomyosis.

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  • (PMID = 15014950.001).
  • [ISSN] 0932-0067
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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50. Chaudhry IH, Calonje E: Dermal non-neural granular cell tumour (so-called primitive polypoid granular cell tumour): a distinctive entity further delineated in a clinicopathological study of 11 cases. Histopathology; 2005 Aug;47(2):179-85
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  • [Title] Dermal non-neural granular cell tumour (so-called primitive polypoid granular cell tumour): a distinctive entity further delineated in a clinicopathological study of 11 cases.
  • AIMS: Cutaneous and soft tissue granular cell tumour is a well-characterized benign neoplasm of neural origin.
  • However, there remains a subcategory of granular cell tumour, first described by Le Boit as 'primitive polypoid granular cell tumour', that shows no obvious line of differentiation.
  • METHODS AND RESULTS: Eleven cases of dermal non-neural granular cell tumour were retrieved from one of the authors referral archives (E.C.) and both the histology and immunohistochemistry reviewed.
  • The tumours were composed of elongated spindle-shaped to polygonal or round cells with prominent granular cell change, and tumour nuclei showing mild focal atypia to rare moderate atypia.
  • Immunohistochemical labelling of the tumour cells demonstrated expression for NKI-C3 (n = 11), focal, weak positivity for CD68 (n = 10) and FXIIIa (n = 2).
  • There was negative staining for S100 protein, smooth muscle actin, Melan-A, CD34, desmin and cytokeratin.
  • [MeSH-major] Granular Cell Tumor / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Biomarkers, Tumor / analysis. Child. Factor XIIIa / analysis. Female. Humans. Immunohistochemistry. Lysosomes / immunology. Male. Middle Aged

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  • (PMID = 16045779.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human; EC 2.3.2.13 / Factor XIIIa
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51. Plewka A, Madej P, Plewka D, Nowaczyk G, Morek M, Bogunia E, Ciupińska-Kajor M, Sieroń-Stołtny K: The TRAF2 and TRAF6 expression in myomas and myometrium of women in reproduction and perimenopausal age. Folia Histochem Cytobiol; 2010 Sep 30;48(3):407-16
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  • [Title] The TRAF2 and TRAF6 expression in myomas and myometrium of women in reproduction and perimenopausal age.
  • Uterine myomas represent one of the most common female diseases.
  • Uterine myomas or fibromas are benign, hormone-responding tumours of, respectively, smooth muscles and fibroblasts and their aetiology induces a significant interest.
  • In myomas the presence of aromatase was detected and, in addition, oestrogen was found to be synthesized in myoma cells.
  • The studies were performed on myoma patients of generative age and those in peri-menopausal age.
  • Expression of TRAF2 and TRAF6 proteins was examined using immunohistochemistry and Western blot approach in small and large uterine myomas isolated from women of various age.
  • In addition, the evaluation was conducted at the periphery of every myoma.
  • We indicated that the level of both tested proteins in myomas is higher than in control.
  • TRAF2 level in myometrium was lower than in myomas but higher than in control.

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  • (PMID = 21071347.001).
  • [ISSN] 1897-5631
  • [Journal-full-title] Folia histochemica et cytobiologica
  • [ISO-abbreviation] Folia Histochem. Cytobiol.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / TNF Receptor-Associated Factor 2; 0 / TNF Receptor-Associated Factor 6; EC 1.14.14.1 / Aromatase
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52. Sinha R, Sundaram M, Lakhotia S, Hegde A: Cervical myomectomy with uterine artery ligation at its origin. J Minim Invasive Gynecol; 2009 Sep-Oct;16(5):604-8
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  • This study was performed to examine the feasibility, blood loss, duration of surgery, and complications in patients with cervical myomas in whom the uterine artery was ligated before myomectomy.
  • Laparoscopic cervical myomectomy was performed in 12 women with cervical myomas and menorrhagia.
  • Myomectomy was subsequently performed, and the myomas were enucleated by incising the capsule anteriorly or posteriorly depending on their location.
  • Even large cervical myomas were removed with minimal blood loss.


53. Reinblatt SL, Krishnamurthy S, Valenti D, Tulandi T: Septic uterus after uterine artery embolization for uterine myomas triggered by endometrial biopsy. J Obstet Gynaecol Can; 2008 Apr;30(4):344-346
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  • [Title] Septic uterus after uterine artery embolization for uterine myomas triggered by endometrial biopsy.
  • Both patients had large and necrotic intramural myomas adjacent to the endometrium.
  • CONCLUSION: Because of the high risk of infection, women with a history of UAE and necrotic myoma adjacent to the endometrium should not undergo endometrial biopsy.
  • We recommend evaluation of the relation of myomas to the endometrium.
  • [MeSH-major] Abscess / etiology. Embolization, Therapeutic / adverse effects. Uterine Diseases / etiology. Uterine Hemorrhage / therapy. Uterus / blood supply

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  • (PMID = 18430385.001).
  • [ISSN] 1701-2163
  • [Journal-full-title] Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
  • [ISO-abbreviation] J Obstet Gynaecol Can
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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54. Ballesteros Manzo A, Barros Delgadillo JC, Ochoa Rueda S, Villalobos Acosta S, Barroso Villa G, Sánchez Solís V, Gaviño Gaviño F: [Effect of intramural and subserous myomas on in vitro fertilization cycles and their perinatal results]. Ginecol Obstet Mex; 2006 Jan;74(1):55-65
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  • [Title] [Effect of intramural and subserous myomas on in vitro fertilization cycles and their perinatal results].
  • [Transliterated title] Efecto de los miomas intramurales y subserosos en los ciclos de fertilización in vitro y sus resultados perinatales.
  • OBJECTIVE: To evaluate the effect of intramural and subserous myomas in in vitro fertilization cycles, as well as its perinatal results.
  • The variables of size and type of myomas, as well as variables of IVF cycles, implantation and pregnancy rates, and perinatal results were analyzed.
  • We calculated the chi-square test to analyze the relationship between myomas and pregnancy.
  • RESULTS: We analyzed 431 cycles made in 364 patients divided into two groups: study cases (with myomas-65 cycles) and control cases (without myomas-366 cycles).
  • Logistic regression showed that myomas do not affect the possibility of getting pregnant.
  • CONCLUSION: Intramural and subserous myomas < 5 cm do not seem to have an effect in the IVF cycles nor in its perinatal results.
  • In women with myomas < 5 cm that no dot distortion the uterine cavity it is questionable the usefulness of a myomectomy prior to IVF cycles.
  • [MeSH-minor] Adult. Female. Humans. Myoma. Pregnancy. Pregnancy Rate

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  • (PMID = 16634354.001).
  • [ISSN] 0300-9041
  • [Journal-full-title] Ginecología y obstetricia de México
  • [ISO-abbreviation] Ginecol Obstet Mex
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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55. Brown L: Pathology of uterine malignancies. Clin Oncol (R Coll Radiol); 2008 Aug;20(6):433-47
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  • The distinction of type I and type II endometrial adenocarcinoma with the morphological variants of this tumour is discussed and some molecular aspects are explored.
  • Some types of mixed epithelial and stromal neoplasm are described and contrasted with carcinosarcoma.
  • The concept of stromal sarcoma and high-grade uterine sarcoma is described and an outline of malignant smooth muscle tumours of the uterus includes a description of smooth muscle tumours of uncertain malignant potential and worrying benign smooth muscle lesions.

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  • (PMID = 18499412.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 233
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56. Squillaci S, Cecchetti D, Tallarigo F, Pontieri F, Filardo AV: [Myopericytoma-type perivascular myoma located in the soft tissue of the foot: a case report and review of the literature]. Pathologica; 2005 Dec;97(6):378-82
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  • [Title] [Myopericytoma-type perivascular myoma located in the soft tissue of the foot: a case report and review of the literature].
  • [Transliterated title] Mioma perivascolare di tipo miopericitoma dei tessuti molli del piede: descrizione di un caso e revisione della letteratura.
  • We describe a rare case of myopericytoma-type perivascular myoma (MTPM) which arose in acral location and the literature on this field is briefly reviewed.
  • Immunohistochemically, the neoplastic cells were positive for vimentin, smooth muscle actin, desmin and calponin, negative for S-100 protein, CD34, CD31 and cytokeratins (AE1/AE3, Cam 5.2).
  • [MeSH-major] Foot Diseases / pathology. Myoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16619980.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 16
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57. Ouellet P, Bergeron ME, Lapointe D, Laberge P, Côté M: [Severe hyponatremia associated with transcervical resection of a uterine myoma]. Can J Anaesth; 2010 Feb;57(2):181-2
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  • [Title] [Severe hyponatremia associated with transcervical resection of a uterine myoma].
  • [Transliterated title] Hyponatrémie sévère au cours d'une résection endoscopique d'un myome utérin.

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  • [CommentOn] Can J Anaesth. 2009 Apr;56(4):316-9 [19252964.001]
  • (PMID = 19904578.001).
  • [ISSN] 1496-8975
  • [Journal-full-title] Canadian journal of anaesthesia = Journal canadien d'anesthésie
  • [ISO-abbreviation] Can J Anaesth
  • [Language] fre
  • [Publication-type] Comment; Comparative Study; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anesthetics, General; 0 / Anesthetics, Local; TE7660XO1C / Glycine
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58. Palmara V, Triolo O, Benedetto V, Lo Re C, Sturlese E, Retto G, Santoro G: Morphologic patterns of human endometrial epithelium in women with uterine myomata treated with leuprorelin acetate. Gynecol Obstet Invest; 2010;69(2):131-5
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  • [Title] Morphologic patterns of human endometrial epithelium in women with uterine myomata treated with leuprorelin acetate.
  • AIM: We studied morphologic modifications of the endometrium induced by leuprorelin acetate, a gonadotropin-releasing hormone agonist, in women with uterine myomata.
  • RESULTS: A near-normal endometrium was observed after 2 months of therapy, while treatment with 6 cycles of leuprorelin acetate induced a uniform morphologic regression of the uterine mucosa.


59. Gavai M, Berkes E, Fekete T, Lazar L, Takacs ZF, Papp Z: Analysis of perioperative morbidity according to whether the uterine cavity is opened or remains closed during abdominal myomectomy--results of 423 abdominal myomectomy cases. Clin Exp Obstet Gynecol; 2008;35(2):107-12
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  • When submucosal myomas are present or multiple fibroids are to be removed, opening the uterine cavity during the surgical procedure is more likely to happen.

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  • (PMID = 18581763.001).
  • [ISSN] 0390-6663
  • [Journal-full-title] Clinical and experimental obstetrics & gynecology
  • [ISO-abbreviation] Clin Exp Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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60. Litta P, Merlin F, Saccardi C, Pozzan C, Sacco G, Fracas M, Capobianco G, Dessole S: Role of hysteroscopy with endometrial biopsy to rule out endometrial cancer in postmenopausal women with abnormal uterine bleeding. Maturitas; 2005 Feb 14;50(2):117-23
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  • RESULTS: Histological findings for <4 mm level revealed that atrophy was present in 48 (65%) and in 2 cases (2.7%) endometrial cancer was found; for > or = 4 mm values polyps and myomas were present in 86 (59%) and there were 11 (7.5%) endometrial cancer.
  • CONCLUSIONS: In conclusion, endometrial thickness <4 mm can miss malignancies but trans-vaginal ultrasound remains the first line diagnostic procedure in postmenopausal women without AUB, because it is not invasive and has high sensitivity for detecting endometrial cancer and other endometrial disease; according to our experience, outpatient hysteroscopy with biopsy is mandatory in all postmenopausal women with AUB.


61. Zhang L, Liao Q: Effects of testosterone and metformin on glucose metabolism in endometrium. Fertil Steril; 2010 May 1;93(7):2295-8
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  • PATIENT(S): Premenopausal women undergoing total abdominal hysterectomy for uterine myoma or adenomyosis.
  • [MeSH-minor] Adult. Cells, Cultured. Endometriosis / metabolism. Endometriosis / pathology. Epithelial Cells / drug effects. Epithelial Cells / metabolism. Female. Follicular Phase / metabolism. Gene Expression Regulation / drug effects. Glucose Transporter Type 4 / genetics. Glucose Transporter Type 4 / metabolism. Humans. Hypoglycemic Agents / pharmacology. Insulin Receptor Substrate Proteins / genetics. Insulin Receptor Substrate Proteins / metabolism. Leiomyoma / metabolism. Leiomyoma / pathology. Middle Aged. Uterine Diseases / metabolism. Uterine Diseases / pathology. Uterine Neoplasms / metabolism. Uterine Neoplasms / pathology

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  • [Copyright] Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
  • (PMID = 19328476.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glucose Transporter Type 4; 0 / Hypoglycemic Agents; 0 / IRS1 protein, human; 0 / Insulin Receptor Substrate Proteins; 3XMK78S47O / Testosterone; 9100L32L2N / Metformin; IY9XDZ35W2 / Glucose
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62. Kwon YI, Kim TH, Sohn JW, Yoon HJ, Shin DH, Park SS: Benign pulmonary metastasizing leiomvomatosis: case report and a review of the literature. Korean J Intern Med; 2006 Sep;21(3):173-7
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  • [Title] Benign pulmonary metastasizing leiomvomatosis: case report and a review of the literature.
  • She had undergone hysterectomy 16 years previously for uterine myoma.
  • An open lung biopsy revealed tumor that was composed of interlacing bundles of spindle cells with cigar shaped nucleus and eosinophilic myofibrils in the cytoplasm; consistent with multiple leiomyomas.
  • We report here on an interesting case of benign metastasizing leiomyoma (BML) in 51-year-old patient.
  • [MeSH-minor] Disease Progression. Female. Humans. Hysterectomy. Middle Aged. Ovariectomy

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  • (PMID = 17017666.001).
  • [ISSN] 1226-3303
  • [Journal-full-title] The Korean journal of internal medicine
  • [ISO-abbreviation] Korean J. Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Korea (South)
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63. Saitoh M, Hayasaka T, Ohmichi M, Kurachi H, Motoyama T: Primary mucinous adenocarcinoma of the vagina: possibility of differentiating from metastatic adenocarcinomas. Pathol Int; 2005 Jun;55(6):372-5
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  • The patient, a 44-year-old woman, had undergone vaginal total hysterectomy 10 years previously for myoma uteri corporis.
  • The histological features of the vaginal intramural tumor found in this patient resembled those of mucinous adenocarcinoma of the endocervical type.
  • Therefore, it was necessary to determine whether or not the tumor was metastatic from an occult cervical adenocarcinoma.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adult. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Mucin 5AC. Mucin-1 / analysis. Mucin-2. Mucin-6. Mucins / analysis. Neoplasm Metastasis. Vagina / chemistry. Vagina / pathology

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  • (PMID = 15943796.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / MUC2 protein, human; 0 / MUC5AC protein, human; 0 / MUC6 protein, human; 0 / Mucin 5AC; 0 / Mucin-1; 0 / Mucin-2; 0 / Mucin-6; 0 / Mucins
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64. Tse GM, Tan PH, Lui PC, Gilks CB, Poon CS, Ma TK, Law BK, Lam WW: The role of immunohistochemistry for smooth-muscle actin, p63, CD10 and cytokeratin 14 in the differential diagnosis of papillary lesions of the breast. J Clin Pathol; 2007 Mar;60(3):315-20
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  • [Title] The role of immunohistochemistry for smooth-muscle actin, p63, CD10 and cytokeratin 14 in the differential diagnosis of papillary lesions of the breast.
  • The evaluation of myoepithelial cells can be helpful, with benign papilloma showing a continuous myoepithelial cell layer, which becomes attenuated or absent in malignant papillary lesions.
  • METHODS: A large series of 100 papillomas (28 papillomas with florid epithelial hyperplasia) and 68 papillary carcinomas (9 invasive, 44 in situ, and 15 ductal carcinomas in situ (DCIS) involving papillomas) of the breast were stained for myoepithelial cells by immunohistochemistry using antibodies to smooth-muscle actin (SMA), p63, CD10 and cytokeratin (CK) 14.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Breast Neoplasms / metabolism
  • [MeSH-minor] Actins / metabolism. Adult. Aged. Aged, 80 and over. Carcinoma, Intraductal, Noninfiltrating / metabolism. Carcinoma, Intraductal, Noninfiltrating / pathology. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. DNA-Binding Proteins / metabolism. Diagnosis, Differential. Female. Humans. Keratin-14 / metabolism. Middle Aged. Neoplasm Proteins / metabolism. Neprilysin / metabolism. Papilloma / metabolism. Papilloma / pathology. Papilloma, Intraductal / metabolism. Papilloma, Intraductal / pathology. Trans-Activators / metabolism. Transcription Factors. Tumor Suppressor Proteins / metabolism

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  • (PMID = 16698948.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Keratin-14; 0 / Neoplasm Proteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; EC 3.4.24.11 / Neprilysin
  • [Other-IDs] NLM/ PMC1860581
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65. Ławicki S, Bedkowska GE, Gacuta-Szumarska E, Czygier M, Szmitkowski M: [The plasma levels and diagnostic utility of stem cell factor in patients with endometrial cancer and myoma uteri]. Pol Merkur Lekarski; 2009 Jun;26(156):609-15
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  • [Title] [The plasma levels and diagnostic utility of stem cell factor in patients with endometrial cancer and myoma uteri].
  • THE AIM OF THE STUDY: The plasma level and diagnostic utility of SCF have been investigated in endometrial cancer and myoma patients.
  • MATERIAL AND METHODS: The plasma level of SCF and tumor markers like CA 125 and SCC-Ag in endometrial cancer (50 patients), in myoma uteri (25 patients) and in 25 healthy subjects were determined using enzyme-linked immunosorbent assay (ELISA) and chemiluminescence immunoassay (CMIA).
  • RESULTS: SCF plasma level was significantly higher in endometrial cancer patients comparing to the group with myoma and to the control.
  • The diagnostic sensitivity of SCF was slightly lower than CA 125, and was higher in more advanced tumor stage.
  • Positive and negative predictive values were high for SCF and for CA 125, and were higher in more advanced tumor stage.
  • CONCLUSIONS: Our study suggests that tested cytokine (SCF) can be clinically useful in differentiation of endometrial cancer and myoma uteri.
  • [MeSH-major] Biomarkers, Tumor / blood. CA-125 Antigen / blood. Endometrial Neoplasms / blood. Endometrial Neoplasms / diagnosis. Leiomyoma / blood. Leiomyoma / diagnosis. Stem Cell Factor / blood

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  • (PMID = 19711726.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-125 Antigen; 0 / Stem Cell Factor
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66. Pejić S, Todorović A, Stojiljković V, Cvetković D, Lucić N, Radojicić RM, Saicić ZS, Pajović SB: Superoxide dismutase and lipid hydroperoxides in blood and endometrial tissue of patients with benign, hyperplastic and malignant endometrium. An Acad Bras Cienc; 2008 Sep;80(3):515-22
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  • [Title] Superoxide dismutase and lipid hydroperoxides in blood and endometrial tissue of patients with benign, hyperplastic and malignant endometrium.
  • The objective of the present study was to examine changes in activities and levels of copper/zinc superoxide dismutase (CuZnSOD) and lipid hydroperoxides (LOOH) in blood and endometrial tissue of patients diagnosed with uterine myoma, endometrial polypus, hyperplasia simplex, hyperplasia complex and adenocarcinoma endometrii.
  • Decrease of both SOD activity and level was found in endometrium of patients with hyperplasia simplex, hyperplasia complex and adenocarcinoma in comparison to women with polypus or myoma.
  • LOOH level was elevated in both tissues of patients with hyperplasia or adenocarcinoma in comparison to healthy subjects or patients with benign diagnosis.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Female. Humans. Middle Aged. Polyps / blood. Polyps / enzymology. Uterine Neoplasms / blood. Uterine Neoplasms / enzymology

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  • (PMID = 18797802.001).
  • [ISSN] 0001-3765
  • [Journal-full-title] Anais da Academia Brasileira de Ciências
  • [ISO-abbreviation] An. Acad. Bras. Cienc.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Lipid Peroxides; EC 1.15.1.1 / Superoxide Dismutase
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67. Sheridan T, Herawi M, Epstein JI, Illei PB: The role of P501S and PSA in the diagnosis of metastatic adenocarcinoma of the prostate. Am J Surg Pathol; 2007 Sep;31(9):1351-5
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  • It is expressed in both benign and neoplastic prostate tissues, but not in any other normal or malignant tissue examined to date.
  • The tissue microarray contains 78 cases of metastatic prostatic adenocarcinoma, 20 cases of primary prostatic adenocarcinoma, and 20 cases of benign prostate tissue from the peripheral zone as well as samples of benign brain, pancreas, kidney, thyroid, testis, skeletal muscle, and fibroconnective tissue.
  • RESULTS: Similar staining (intensity and extent) was identified for both markers in the majority of metastatic tumors (11 distant sites, 42 pelvic lymph nodes), in all 20 primary tumors and in all benign prostate and nonprostate tissues.
  • [MeSH-minor] Cell Differentiation. Golgi Apparatus / chemistry. Humans. Immunohistochemistry. Lymph Nodes / chemistry. Lymph Nodes / immunology. Male. Neoplasm Staging. Predictive Value of Tests. Reproducibility of Results. Sensitivity and Specificity. Tissue Array Analysis

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  • (PMID = 17721190.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P50 CA58236
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / prostein; EC 3.4.21.77 / Prostate-Specific Antigen
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68. McLucas B: Collateral supply to uterine leiomyomata from an unnamed vessel: a case report. Minim Invasive Ther Allied Technol; 2009;18(2):106-8
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  • However, myomata have been reported to recruit collateral supply, usually from the ovarian arteries, which may contribute to clinical failure of uterine artery embolization.
  • This case report describes a patient in whom a uterine myoma developed collateral supply de novo.

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  • (PMID = 19255925.001).
  • [ISSN] 1365-2931
  • [Journal-full-title] Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy
  • [ISO-abbreviation] Minim Invasive Ther Allied Technol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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69. Georgiev D, Iankov M, Katsulov A, Vasileva M: [Myoma uteri permagna in pregnancy--a case report and clinical practice]. Akush Ginekol (Sofiia); 2005;44 Suppl 1:6-7
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  • [Title] [Myoma uteri permagna in pregnancy--a case report and clinical practice].


70. Mikami Y, Kiyokawa T, Moriya T, Sasano H: Immunophenotypic alteration of the stromal component in minimal deviation adenocarcinoma ('adenoma malignum') and endocervical glandular hyperplasia: a study using oestrogen receptor and alpha-smooth muscle actin double immunostaining. Histopathology; 2005 Feb;46(2):130-6
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  • [Title] Immunophenotypic alteration of the stromal component in minimal deviation adenocarcinoma ('adenoma malignum') and endocervical glandular hyperplasia: a study using oestrogen receptor and alpha-smooth muscle actin double immunostaining.
  • AIMS: To define the phenotypic alteration of the stromal component in association with destructive invasion which is a crucial feature in distinguishing minimal deviation adenocarcinoma (MDA) from benign endocervical glandular lesions.
  • METHODS AND RESULTS: We studied endocervical glandular hyperplasias including non-specific-type (NEGH) (n = 3) and lobular-type (LEGH) (n = 8), and minimal deviation adenocarcinoma (MDA) (n = 11), well-differentiated endocervical adenocarcinoma of usual-type (WDA) (n = 11), and adenocarcinoma in situ (AIS) (n = 6) of the cervix, by double immunostaining for oestrogen receptor (ER) and alpha-smooth muscle actin (alpha-SMA) using peroxidase- and alkaline phosphatase-polymer methods, respectively.
  • [MeSH-minor] Female. Humans. Hyperplasia. Immunohistochemistry / methods. Metaplasia. Muscle, Smooth / chemistry. Neoplasm Invasiveness


71. Fedele L, Bianchi S, Frontino G: Hormonal treatments for adenomyosis. Best Pract Res Clin Obstet Gynaecol; 2008 Apr;22(2):333-9
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  • Like endometriosis and uterine myomas, adenomyosis presents the typical characteristics of oestrogen-dependent diseases.
  • The medical treatment of adenomyosis is based on the hormonal dependency of the disease and its strongly debated similarities with endometriosis.
  • Although the two diseases have distinct epidemiological features, they have the same 'target tissue' for hormonal therapy, namely ectopic endometrium.
  • Recognized approaches are systemic hormonal treatments, which are generally used for endometriosis and are capable of suppressing the oestrogenic induction of the disease, and local hormonal treatment that targets the ectopic endometrium directly.

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  • (PMID = 17765017.001).
  • [ISSN] 1521-6934
  • [Journal-full-title] Best practice & research. Clinical obstetrics & gynaecology
  • [ISO-abbreviation] Best Pract Res Clin Obstet Gynaecol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Estrogen Antagonists; 33515-09-2 / Gonadotropin-Releasing Hormone; 5W7SIA7YZW / Levonorgestrel; N29QWW3BUO / Danazol
  • [Number-of-references] 39
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72. Sato H, Nanjo H, Tanaka H, Tanaka T: Arias-Stella reaction in an adenomyomatous polyp of the uterus. Acta Obstet Gynecol Scand; 2007;86(1):106-8
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  • A 33-year-old Japanese woman, gravida 1, para 1, presented for an initial prenatal examination at 6-week gestation; ultrasound revealed a myoma-like solid mass in the cervical canal.


73. Fernández JM, Medlich MA, López LH, Loredo CF, Luque LC: Fetal intermediate rhabdomyoma of the lip: case report. J Clin Pediatr Dent; 2005;29(2):179-80
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  • Fetal rhabdomyoma is a rare benign neoplasm of skeletal muscle that must be distinguished histologically from various malignant lesions, including rhabdomyosarcoma.
  • [MeSH-minor] Diagnosis, Differential. Humans. Infant. Male. Rare Diseases / pathology

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  • (PMID = 15719926.001).
  • [ISSN] 1053-4628
  • [Journal-full-title] The Journal of clinical pediatric dentistry
  • [ISO-abbreviation] J Clin Pediatr Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Kumakiri J, Kikuchi I, Kitade M, Kumakiri Y, Kuroda K, Matsuoka S, Tokita S, Takeda S: Evaluation of factors contributing to uterine scar formation after laparoscopic myomectomy. Acta Obstet Gynecol Scand; 2010 Aug;89(8):1078-83
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  • Factors influencing scar formation in 305 patients with an enucleated solitary myoma.
  • Deformation of the endometrium found by preoperative imaging and complete myometrial penetration during LM had a positive correlation and the number of enucleated myomas a negative correlation with scar formation.
  • Significant factors associated with scar formation were complete myometrial penetration (odds ratio, 2.53; 95% confidence interval, 1.30-4.93; p = 0.006) and enucleation of a subserosal myoma (odds ratio, 0.23; 95% confidence interval, 0.08-0.70; p = 0.009).

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  • (PMID = 20636246.001).
  • [ISSN] 1600-0412
  • [Journal-full-title] Acta obstetricia et gynecologica Scandinavica
  • [ISO-abbreviation] Acta Obstet Gynecol Scand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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75. Junqueira MG, da Silva ID, Nogueira-de-Souza NC, Carvalho CV, Leite DB, Gomes MT, Baracat EC, Lopes LA, Nicolau SM, Gonçalves WJ: Progesterone receptor (PROGINS) polymorphism and the risk of endometrial cancer development. Int J Gynecol Cancer; 2007 Jan-Feb;17(1):229-32
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  • The progesterone receptor gene (PROGINS) has been identified as a risk modifier for benign and malignant gynecological diseases.
  • Regarding the clinical and pathologic findings observed within the group of patients with endometrial cancer, there was significant correlation between T1/T2 genotype and the presence of myoma (P= 0.048).
  • [MeSH-minor] Aged. Alleles. Case-Control Studies. Female. Genetic Predisposition to Disease. Humans. Middle Aged. Neoplasm Staging. Polymorphism, Genetic

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  • (PMID = 17291258.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Progesterone
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76. Martín-Ondarza C, Gil-Moreno A, Torres-Cuesta L, García A, Eyzaguirre F, Díaz-Feijoo B, Xercavins J: Endometrial cancer in polyps: a clinical study of 27 cases. Eur J Gynaecol Oncol; 2005;26(1):55-8
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  • Ultrasonography performed in 22 patients showed images compatible with an endometrial polyp in 50% of cases, myoma in 5%, and inconclusive findings in 45%.

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  • (PMID = 15755002.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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77. Chen L, Yang B: Immunohistochemical analysis of p16, p53, and Ki-67 expression in uterine smooth muscle tumors. Int J Gynecol Pathol; 2008 Jul;27(3):326-32
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  • [Title] Immunohistochemical analysis of p16, p53, and Ki-67 expression in uterine smooth muscle tumors.
  • Despite well-established criteria, the distinction of uterine leiomyosarcoma from certain variants of benign leiomyoma, particularly bizarre leiomyoma, can be challenging morphologically.
  • We had immunohistochemically studied the expression of p16, p53, and Ki-67 proteins in 100 cases of uterine smooth muscle tumors, including 35 usual leiomyomas (LM), 13 cellular leiomyomas (CLM), 15 bizarre leiomyomas (BLM), 2 cases of smooth muscle tumor of uncertain malignant potential (STUMP), and 35 leiomyosarcoma (LMS).
  • [MeSH-major] Ki-67 Antigen / analysis. Leiomyoma / diagnosis. Leiomyosarcoma / diagnosis. Neoplasm Proteins / analysis. Tumor Suppressor Protein p53 / analysis. Uterine Neoplasms / diagnosis

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  • (PMID = 18580309.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Neoplasm Proteins; 0 / P16 protein, human; 0 / Tumor Suppressor Protein p53
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78. Tsai CY, Wei FC, Chang YL, Chen YY, Chen CT: Vastus lateralis muscle flap used for reconstruction of the maxilla after radical resection of recurrent ameloblastoma. Chang Gung Med J; 2006 May-Jun;29(3):331-5
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  • [Title] Vastus lateralis muscle flap used for reconstruction of the maxilla after radical resection of recurrent ameloblastoma.
  • Maxillary ameloblastoma is a benign odontogenic neoplasm.
  • Simultaneous reconstruction was performed with an iliac crest bone graft for the orbital floor, and a vastus lateralis muscle flap for obliteration of the maxillary sinus and repair the oral and nasal cavities.
  • The transferred vastus lateralis muscle already had spontaneous mucosalization over its surface two weeks after surgery.
  • The use of a single vastus lateralis muscle flap to repair both oral and nasal cavities is advantageous.
  • The conventional iliac bone graft supported by a well vascularized muscle eventually survived and provided a good functional and cosmetic result.
  • [MeSH-major] Ameloblastoma / surgery. Maxilla / surgery. Maxillary Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Surgical Flaps

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  • (PMID = 16924896.001).
  • [ISSN] 2072-0939
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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79. Crha I, Pospísil L, Stroblová H, Ventruba P, Záková J, Huser M: [Antibodies against the chlamydial heat shock protein in women with periadnexal adhesions]. Ceska Gynekol; 2006 Mar;71(2):127-31
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  • RESULTS: Twenty-four women (31.6%) had normal finding in small pelvis.
  • Periadnexal adhesions were detected in 43 (56.6%) patients, hydrosalpinx in 13 cases (17.1%), endometriosis in 27 (35.5%) patients and uterine myomas in 11 (145%) women.

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  • (PMID = 16649414.001).
  • [ISSN] 1210-7832
  • [Journal-full-title] Ceska gynekologie
  • [ISO-abbreviation] Ceska Gynekol
  • [Language] CZE
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Chaperonin 60; 0 / Immunoglobulin G
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80. Steiner RA, Fehr PM: [Minimal invasive surgery in gynaecology]. Ther Umsch; 2005 Feb;62(2):127-38
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  • [Transliterated title] Minimal-invasive Chirurgie in der Gynäkologie.
  • Today patients can profit of these new techniques in all fields of gynaecological surgery, some of which are described: The treatment of benign adnexal pathology including ectopic pregnancy is a domain of laparoscopy.
  • Also symptomatic myomas can be enucleated by laparoscopy with favourable pregnancy outcome.
  • The role of endoscopy in malignant disease has still to be defined though pelvic and paraaortal lymphonodectomy and even radical hysterectomy have been shown to be feasible.
  • Pathology of the uterine cavity (myomas, polyps, septae) is routinely treated by hysteroscopy.
  • [MeSH-major] Genital Diseases, Female / surgery. Hysteroscopy. Laparoscopy. Minimally Invasive Surgical Procedures

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  • (PMID = 15756923.001).
  • [ISSN] 0040-5930
  • [Journal-full-title] Therapeutische Umschau. Revue thérapeutique
  • [ISO-abbreviation] Ther Umsch
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 60
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81. Darwish AM, Nasr AM, El-Nashar DA: Evaluation of postmyomectomy uterine scar. J Clin Ultrasound; 2005 May;33(4):181-6
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  • A preoperative myoma size greater than 110 cm(3), the use of a tourniquet, and the experience of the surgeon were significantly correlated with formation of uterine scar hematomas.


82. Lokeshwar VB, Cerwinka WH, Isoyama T, Lokeshwar BL: HYAL1 hyaluronidase in prostate cancer: a tumor promoter and suppressor. Cancer Res; 2005 Sep 1;65(17):7782-9
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  • [Title] HYAL1 hyaluronidase in prostate cancer: a tumor promoter and suppressor.
  • However, it is controversial whether hyaluronidase (e.g., HYAL1) functions as a tumor promoter or as a suppressor.
  • Blocking HYAL1 expression inhibited tumor growth by 4- to 7-fold, whereas high HYAL1 producing transfectants either did not form tumors (DU145) or grew 3.5-fold slower (PC-3 ML).
  • Whereas vector and moderate HYAL1 producers generated muscle and blood vessel infiltrating tumors, HYAL1-AS tumors were benign and contained smaller capillaries.
  • Specimens of high HYAL1 producers were 99% free of tumor cells.
  • This study shows that, depending on the concentration, HYAL1 functions as a tumor promoter and as a suppressor and provides a basis for anti-hyaluronidase and high-hyaluronidase treatments for cancer.
  • [MeSH-minor] Animals. Apoptosis / physiology. Cell Cycle / physiology. Cell Growth Processes / physiology. Cell Line, Tumor. DNA, Antisense / genetics. Humans. Hyaluronic Acid / biosynthesis. Isoenzymes. Male. Mice. Mice, Nude. Neoplasm Transplantation. Neovascularization, Pathologic / enzymology. Transfection. Transplantation, Heterologous

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  • (PMID = 16140946.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 2R01-CA061038; United States / PHS HHS / / R01 072821-06
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Antisense; 0 / Isoenzymes; 9004-61-9 / Hyaluronic Acid; EC 3.2.1.35 / Hyaluronoglucosaminidase
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83. Gleason BC, Fletcher CD: Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential. Am J Surg Pathol; 2008 Mar;32(3):354-62
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  • [Title] Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential.
  • Benign fibrous histiocytoma (FH) is one of the most common mesenchymal neoplasms of the skin.
  • Deep benign FH is an uncommon and poorly recognized clinical subtype that arises in subcutaneous or deep soft tissue.
  • Immunohistochemistry revealed expression of CD34 in 20/50 cases (40%), smooth muscle actin in 15/40 (38%), and focal desmin in 1/12 (8%).
  • Of the 37 patients for whom clinical follow-up was available (median, 40 mo), 8 (22%) had a local recurrence; in all 8 cases, the tumor had been marginally or incompletely excised.
  • Metastases occurred in 2 patients (5%), both of whom ultimately died of disease; however, this number is likely exaggerated due to consultation bias.
  • The metastasizing tumors were large (6 and 9 cm) and 1 had tumor necrosis but they were otherwise histologically identical to the nonmetastasizing lesions.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Neoplasm Metastasis / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Actins / analysis. Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD34 / analysis. Child. Desmin / analysis. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mitosis. Necrosis. Neoplasm Recurrence, Local

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  • (PMID = 18300816.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD34; 0 / Desmin
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84. Alborzi S, Ghannadan E, Alborzi S, Alborzi M: A comparison of combined laparoscopic uterine artery ligation and myomectomy versus laparoscopic myomectomy in treatment of symptomatic myoma. Fertil Steril; 2009 Aug;92(2):742-7
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  • [Title] A comparison of combined laparoscopic uterine artery ligation and myomectomy versus laparoscopic myomectomy in treatment of symptomatic myoma.
  • PATIENT(S): Of 152 women with symptomatic uterine myomas necessitating surgical intervention who wished to retain their uteri, 65 underwent laparoscopic uterine artery ligation and myomectomy (experimental group) and 87 received laparoscopic myomectomy only (control group).
  • In the experimental group, the recurrence of myoma was 6.2%, and 98.1% of the patients reported symptoms improvement; however, in the control group, these figures were 20.75% and 83.1%, respectively (statistically significant).
  • CONCLUSION(S): This study demonstrated the superiority of laparoscopic uterine artery ligation combined with myomectomy in treatment of symptomatic myomas.

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  • (PMID = 18692826.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] United States
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85. Moretti D, Del Bello B, Cosci E, Biagioli M, Miracco C, Maellaro E: Novel variants of muscle calpain 3 identified in human melanoma cells: cisplatin-induced changes in vitro and differential expression in melanocytic lesions. Carcinogenesis; 2009 Jun;30(6):960-7
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  • [Title] Novel variants of muscle calpain 3 identified in human melanoma cells: cisplatin-induced changes in vitro and differential expression in melanocytic lesions.
  • Alterations of calpain 3 (p94), the muscle-specific isoform that contains three peculiar sequences (NS, IS1 and IS2), are strictly associated to the limb-girdle muscular dystrophy type 2A, in which a myonuclear apoptosis has been documented.
  • Interestingly, among melanocytic lesions, the expression of these novel variants is significantly downregulated, compared with benign nevi, in the most aggressive ones, i.e. in vertical growth phase melanoma and, even more, in metastatic melanoma cells, characterized by invasiveness properties and usually highly resistant to apoptosis.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Calpain / metabolism. Cisplatin / pharmacology. Melanoma / metabolism. Muscle Proteins / metabolism. Nevus / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Alternative Splicing. Apoptosis. Biopsy. Cell Line, Tumor. Cell Nucleolus / metabolism. Cytoplasm / metabolism. Dipeptides / pharmacology. Dysplastic Nevus Syndrome / metabolism. Gene Expression Regulation, Neoplastic. Humans. Neoplasm Metastasis. RNA, Messenger / metabolism


86. Shin JH, Han BK, Ko EY, Kang SS: Sonographic findings in the surgical bed after thyroidectomy: comparison of recurrent tumors and nonrecurrent lesions. J Ultrasound Med; 2007 Oct;26(10):1359-66
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  • The 36 nonrecurrent lesions included remnant thyroidal tissue (n = 8), postoperative fibrosis (n = 7), suture granuloma (n = 7), strap muscle with a nodular contour (n = 4), reactive lymph nodes (n = 4), cysts (n = 3), tracheal cartilage (n = 2), and fat necrosis (n = 1).
  • CONCLUSIONS: For lesions located in the surgical bed in patients after thyroidectomy, the distinction between recurrent thyroid cancer and nonrecurrent benign lesions cannot be made on the basis of the sonographic features.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Chi-Square Distribution. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / ultrasonography. Retrospective Studies

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  • (PMID = 17901139.001).
  • [ISSN] 0278-4297
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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87. Lahaye MJ, Beets GL, Engelen SM, Kessels AG, de Bruïne AP, Kwee HW, van Engelshoven JM, van de Velde CJ, Beets-Tan RG: Locally advanced rectal cancer: MR imaging for restaging after neoadjuvant radiation therapy with concomitant chemotherapy. Part II. What are the criteria to predict involved lymph nodes? Radiology; 2009 Jul;252(1):81-91
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  • Signal intensity (SI) in gluteus muscle (SI(GM)) and in total node (SI(TN)) were used to calculate SI(TN)/SI(GM) ratio.
  • CONCLUSION: The most reliable predictors for identifying benign nodes after radiation therapy with concomitant chemotherapy by using USPIO-enhanced MR imaging for restaging in patients with rectal cancer were estimated percentage of white region within the node and Ratio(A).
  • Measurements on standard 2D T2-weighted fast spin-echo images versus primary staging results offer reasonably good accuracy to identify benign lymph nodes after therapy.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoadjuvant Therapy. Neoplasm Staging. Reproducibility of Results. Sensitivity and Specificity. Treatment Outcome

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  • [Copyright] (c) RSNA, 2009.
  • (PMID = 19403848.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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88. Lai CC, Chang CK, Wang JY: Hypertension secondary to bilateral hydronephrosis caused by a large uterine myoma. Am J Kidney Dis; 2009 Dec;54(6):1187
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  • [Title] Hypertension secondary to bilateral hydronephrosis caused by a large uterine myoma.

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  • (PMID = 19932880.001).
  • [ISSN] 1523-6838
  • [Journal-full-title] American journal of kidney diseases : the official journal of the National Kidney Foundation
  • [ISO-abbreviation] Am. J. Kidney Dis.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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89. Bodle JF, Duffy SR, Binney DM: Susceptibility of uterine myomas and endometrium to cryosurgery using a carbon dioxide cryosurgical probe in vitro. J Minim Invasive Gynecol; 2006 Nov-Dec;13(6):500-4
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  • [Title] Susceptibility of uterine myomas and endometrium to cryosurgery using a carbon dioxide cryosurgical probe in vitro.
  • STUDY OBJECTIVE: To determine the effect of a 9-mm diameter carbon dioxide cryoprobe, the Endocryo, on myomas and endometrial/myometrial tissue in vitro.
  • DESIGN: Comparative laboratory study (Canadian Task Force classification II-2).
  • PATIENTS: Women with and without myomas, undergoing hysterectomy.
  • INTERVENTION: A single 5-minute freeze followed by an active thaw was applied to uterine myomas and endometrial/myometrial tissue in vitro.
  • MEASUREMENTS AND MAIN RESULTS: Endometrial/myometrial and uterine myoma temperature change was measured continuously during the cryosurgical procedure.
  • There was no significant difference in temperature change and depth of cell death between myomas and endometrial/myometrial tissue in vitro.
  • CONCLUSIONS: The Endocryo produces the same cryosurgical effect on both uterine myomas and endometrial/myometrial tissue in vitro, an important principal for future development of a clinically effective cryosurgical device for the treatment of menorrhagia in the presence of submucous myomas.

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  • (PMID = 17097569.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 142M471B3J / Carbon Dioxide
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90. Sinha R, Hegde A, Warty N, Mahajan C: Laparoscopic myomectomy: enucleation of the myoma by morcellation while it is attached to the uterus. J Minim Invasive Gynecol; 2005 May-Jun;12(3):284-9
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  • [Title] Laparoscopic myomectomy: enucleation of the myoma by morcellation while it is attached to the uterus.
  • STUDY OBJECTIVE: To evaluate the feasibility, blood loss, length of surgery, mean hospital stay, and complications of enucleation of a myoma by morcellation while it is still attached to the uterus and to compare the technique with the standard technique of laparoscopic myomectomy.
  • DESIGN: Randomized study (Canadian Task Force classification II-2).
  • PATIENTS: Forty-four patients with symptomatic myomas confirmed by ultrasound examination were included in the study from January 2000 through December 2001 and were randomized into two groups-A and B.
  • The inclusion criteria were the presence of a uterus larger than 12 weeks (on bimanual examination), ultrasound confirmation of the presence of at least one myoma 7 cm or greater in size, and/or presence of three or more myomas greater than 5 cm in size.
  • INTERVENTION: The technique of laparoscopic myomectomy by enucleation of a myoma by morcellation while it is still attached to the uterus was performed in all patients in Group A.
  • The patients in Group B underwent laparoscopic myomectomy by the conventional technique of complete enucleation of the myoma followed by morcellation.
  • MEASUREMENTS AND MAIN RESULTS: Forty-nine myomas were removed in group A and 35 in group B.
  • The mean weight of the myomas removed in each patient was 600.5 +/- 369.1 g in group A (95% CI 452.83-748.17 g) and 584.2 +/- 411.1 g in group B (95% CI 404.05-764.45 g) (p = .706).
  • CONCLUSION: Preliminary results suggest that laparoscopic myomectomy employing the technique of enucleation of a myoma by morcellation while it is still attached to the uterus is safe and efficient.
  • It may help to relax the inclusion criteria of patients with myoma for laparoscopic myomectomy based on the size of the myoma.

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  • (PMID = 15922988.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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91. Jeffery IB, Madden SF, McGettigan PA, Perrière G, Culhane AC, Higgins DG: Integrating transcription factor binding site information with gene expression datasets. Bioinformatics; 2007 Feb 1;23(3):298-305
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  • We give an example using the Gene Atlas compendium of gene expression levels for human tissues where we search for motifs that are associated with expression in central nervous system (CNS) or muscle tissues.
  • Most of the motifs that we find are known from previous work to be strongly associated with expression in CNS or muscle.
  • We give a second example using a published prostate cancer dataset where we can simply and clearly find which transcriptional pathways are associated with differences between benign and metastatic samples.
  • [MeSH-major] Algorithms. Biomarkers, Tumor / genetics. DNA, Neoplasm / genetics. Gene Expression Profiling / methods. Neoplasm Proteins / genetics. Prostatic Neoplasms / genetics. Transcription Factors / genetics

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  • (PMID = 17127681.001).
  • [ISSN] 1367-4811
  • [Journal-full-title] Bioinformatics (Oxford, England)
  • [ISO-abbreviation] Bioinformatics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Neoplasm Proteins; 0 / Transcription Factors
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92. Schindler AE: Non-contraceptive benefits of hormonal contraceptives. Minerva Ginecol; 2010 Aug;62(4):319-29
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  • Treatment but also prevention can be achieved with hormonal contraceptives in benign proliferative diseases of women, such as ovarian cysts, endometriosis, adenomyosis, endometrial hyperplasia, myoma and benign breast disease.
  • Furthermore, hormonal contraceptives such as estrogen/progestogen combinations reduce pelvic inflammatory disease, rheumatoid arthritis, asthma symptoms and preserve bone density.
  • [MeSH-minor] Adult. Arthritis, Rheumatoid / prevention & control. Asthma / prevention & control. Bone Density / drug effects. Breast Diseases / prevention & control. Colonic Neoplasms / prevention & control. Contraception / methods. Endometrial Hyperplasia / prevention & control. Female. Genital Diseases, Female / prevention & control. Humans. Menstruation Disturbances / prevention & control. Myoma / prevention & control. Ovarian Cysts / prevention & control. Ovarian Neoplasms / prevention & control. Uterine Neoplasms / prevention & control. Virilism / drug therapy

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  • (PMID = 20827249.001).
  • [ISSN] 0026-4784
  • [Journal-full-title] Minerva ginecologica
  • [ISO-abbreviation] Minerva Ginecol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Contraceptives, Oral, Hormonal
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93. Martinelli P, Maruotti GM, Oppedisano R, Agangi A, Mazzarelli LL, Votino C, Quarantelli M, Iaccarino V: Is uterine artery embolization for cervical ectopic pregnancy always safe? J Minim Invasive Gynecol; 2007 Nov-Dec;14(6):758-63
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  • Two patients resumed normal menstruation about 1 month after the procedure, whereas 1 patient underwent a hysterectomy 2 weeks after embolization because of acute ischemic degeneration of a concomitant myoma.


94. Blacksin MF, White LM, Hameed M, Kandel R, Patterson FR, Benevenia J: Granular cell tumor of the extremity: magnetic resonance imaging characteristics with pathologic correlation. Skeletal Radiol; 2005 Oct;34(10):625-31
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  • [Title] Granular cell tumor of the extremity: magnetic resonance imaging characteristics with pathologic correlation.
  • OBJECTIVE: The purpose of this study is to delineate the magnetic resonance (MR) appearance of a granular cell tumor (GrCT) of the extremity and to correlate the imaging appearance with the microscopic findings.
  • DESIGN AND PATIENTS: A retrospective review of five patients with a histopathologic diagnosis of GrCT and pre-operative MR imaging of the neoplasm was done.
  • RESULTS: The benign subtype of GrCT is usually isointense or brighter than muscle on T1-weighted sequences, round or oval in shape, superficial in location, and 4 cm or less in size.
  • On T2-weighted sequences, benign lesions may demonstrate a high peripheral signal, as well as a central signal intensity that is isointense to muscle or suppressed fat.
  • A significant stromal component in the tumor and, hypothetically, a ribbon-like arrangement of tumor cells may influence the signal intensity demonstrated on the T1 and T2-weighted sequences.
  • The malignant subtype may demonstrate signal intensity characteristics and invasion of adjacent structures often seen with other aggressive neoplasms; sizes larger than 4 cm and association with major nerve trunks can be seen.
  • CONCLUSION: Benign GrCT has imaging characteristics which may distinguish this tumor from other soft tissue neoplasms, as well as the malignant type of this tumor.
  • [MeSH-major] Foot Diseases / pathology. Granular Cell Tumor / pathology. Hand / pathology. Shoulder / pathology. Soft Tissue Neoplasms / pathology. Thigh / pathology

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  • (PMID = 16003548.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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95. Sahin K, Akdemir F, Tuzcu M, Sahin N, Onderci M, Ozercan R, Ilhan N, Kilic E, Seren S, Kucuk O: Genistein suppresses spontaneous oviduct tumorigenesis in quail. Nutr Cancer; 2009;61(6):799-806
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This makes it a good animal model for screening potential agents for testing in the prevention and treatment of human myoma uteri.
  • [MeSH-minor] Animals. Avian Proteins / metabolism. Biomarkers / blood. Connexin 43 / metabolism. Coturnix. Dose-Response Relationship, Drug. Female. Humans. Incidence. Isoflavones / blood. Oxidative Stress / drug effects. Proto-Oncogene Proteins c-bcl-2 / metabolism. Random Allocation. Tumor Burden. Uterine Neoplasms / prevention & control. bcl-2-Associated X Protein / metabolism

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  • (PMID = 20155619.001).
  • [ISSN] 1532-7914
  • [Journal-full-title] Nutrition and cancer
  • [ISO-abbreviation] Nutr Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Avian Proteins; 0 / Biomarkers; 0 / Connexin 43; 0 / Isoflavones; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / bcl-2-Associated X Protein; DH2M523P0H / Genistein
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96. Markowska A, Rucinski M, Drews K, Malendowicz LK: Further studies on leptin and leptin receptor expression in myometrium and uterine myomas. Eur J Gynaecol Oncol; 2005;26(5):517-25
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  • [Title] Further studies on leptin and leptin receptor expression in myometrium and uterine myomas.
  • AIM: Examination of the potential role of leptin in the development of uterine myomas.
  • Expression of the leptin gene and leptin receptor gene was tested in the myometrium of healthy women, and in myomas and the surrounding myometrium of women with benign tumors.
  • METHODS: Using RT-PCR, expression of the leptin gene and leptin receptor gene were studied in myomas and in the surrounding myometrium in 30 women with uterine myomas at various phases of the menstrual cycle, and in the myometrium of ten women in a control group.
  • RESULTS: Using RT-PCR, expression of the leptin gene was demonstrated both in myomas and in the surrounding myometrium.
  • CONCLUSION: Demonstration of the expression of leptin genes and leptin proteins in uterine myomas and in the surrounding myometrium, and their absence in the myometrium of healthy women suggests the involvement of leptin in the development of uterine myomas.

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  • (PMID = 16285570.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Leptin; 0 / Receptors, Cell Surface; 0 / Receptors, Leptin; 0 / leptin receptor, human
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97. Mavrelos D, Ben-Nagi J, Davies A, Lee C, Salim R, Jurkovic D: The value of pre-operative treatment with GnRH analogues in women with submucous fibroids: a double-blind, placebo-controlled randomized trial. Hum Reprod; 2010 Sep;25(9):2264-9
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  • BACKGROUND: Submucous fibroids are common benign tumours responsible for menorrhagia, subfertility and miscarriage.
  • They can be readily removed by hysteroscopic transcervical resection of myoma (TCRM).


98. Choi DS, Kim JH, Ryu HS, Kim HC, Han JH, Lee JS, Min CK: Syndecan-1, a key regulator of cell viability in endometrial cancer. Int J Cancer; 2007 Aug 15;121(4):741-50
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  • Immunohistochemical examinations of 109 endometrial tissue samples from myoma, hyperplasia and EC uteri revealed that syndecan-1 expression was significantly upregulated in EC compared with hyperplasia (p < 0.001).
  • [MeSH-minor] Apoptosis. Cell Line. Cell Line, Tumor. Extracellular Signal-Regulated MAP Kinases / metabolism. Female. Humans. Immunohistochemistry. PTEN Phosphohydrolase / metabolism. Phosphorylation. Proto-Oncogene Proteins c-akt / metabolism. RNA Interference. Signal Transduction. Up-Regulation

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  • (PMID = 17455248.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / SDC1 protein, human; 0 / Syndecan-1; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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99. Al-Mahrizi S, Tulandi T: Treatment of uterine fibroids for abnormal uterine bleeding: myomectomy and uterine artery embolization. Best Pract Res Clin Obstet Gynaecol; 2007 Dec;21(6):995-1005
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Uterine myoma is a common benign tumour in women and most cases do not require treatment.
  • Excessive uterine bleeding is usually due to a submucous myoma or an intramural myoma that is encroaching into the uterine cavity.
  • Hysteroscopic myomectomy is highly effective in controlling menorrhagia that is related to submucous myoma.
  • For those with an intramural myoma, abdominal myomectomy results in good bleeding control.

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  • (PMID = 17478123.001).
  • [ISSN] 1521-6934
  • [Journal-full-title] Best practice & research. Clinical obstetrics & gynaecology
  • [ISO-abbreviation] Best Pract Res Clin Obstet Gynaecol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 36
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100. Römer T: Hormone replacement therapy and bleeding disorders. Gynecol Endocrinol; 2006 Mar;22(3):140-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Operative treatments include myoma and polyp resection as well as endometrial ablation.

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  • (PMID = 16835075.001).
  • [ISSN] 0951-3590
  • [Journal-full-title] Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • [ISO-abbreviation] Gynecol. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Estrogens
  • [Number-of-references] 9
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